ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactVI3708 good J KOG1466 Translation, ribosomal structure and biogenesis Translation initiation factor 2B, alpha subunit (eIF-2Balpha/GCN3)
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactVI3708 1294621 1293698 -308
(308 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YKR026c [J] KOG1466 Translation initiation factor 2B alpha subun... 461 e-130
SPCC11E10.07c [J] KOG1466 Translation initiation factor 2B alpha... 272 4e-73
Hs4503503 [J] KOG1466 Translation initiation factor 2B alpha sub... 204 1e-52
At1g72340 [J] KOG1466 Translation initiation factor 2B alpha sub... 190 2e-48
7301868 [J] KOG1466 Translation initiation factor 2B alpha subun... 180 3e-45
CE00367 [J] KOG1466 Translation initiation factor 2B alpha subun... 175 8e-44
At1g53900_2 [J] KOG1466 Translation initiation factor 2B alpha s... 169 5e-42
At1g53880_2 [J] KOG1466 Translation initiation factor 2B alpha s... 169 5e-42
At5g38640 [J] KOG1467 Translation initiation factor 2B delta sub... 85 2e-16
At2g44070 [J] KOG1467 Translation initiation factor 2B delta sub... 83 6e-16
Hs7657058 [J] KOG1465 Translation initiation factor 2B beta subu... 82 1e-15
At3g07300 [J] KOG1465 Translation initiation factor 2B beta subu... 81 2e-15
SPBC23E6.10c [J] KOG1468 Predicted translation initiation factor... 74 3e-13
7302052 [J] KOG1468 Predicted translation initiation factor rela... 71 2e-12
7291571 [J] KOG1467 Translation initiation factor 2B delta subun... 71 2e-12
7290350 [J] KOG1465 Translation initiation factor 2B beta subuni... 70 4e-12
At1g48970 [J] KOG1467 Translation initiation factor 2B delta sub... 69 7e-12
SPAC343.14c [J] KOG1465 Translation initiation factor 2B beta su... 67 4e-11
SPAC21E11.06 [J] KOG1467 Translation initiation factor 2B delta ... 66 7e-11
Hs14165262 [J] KOG1467 Translation initiation factor 2B delta su... 65 1e-10
CE07818 [J] KOG1468 Predicted translation initiation factor rela... 63 6e-10
At2g05830 [J] KOG1468 Predicted translation initiation factor re... 62 1e-09
Hs22051459 [J] KOG1468 Predicted translation initiation factor r... 61 2e-09
YPR118w [J] KOG1468 Predicted translation initiation factor rela... 59 9e-09
YGR083c [J] KOG1467 Translation initiation factor 2B delta subun... 54 2e-07
>YKR026c [J] KOG1466 Translation initiation factor 2B alpha subunit
(eIF-2Balpha/GCN3)
Length = 305
Score = 461 bits (1185), Expect = e-130
Identities = 229/306 (74%), Positives = 266/306 (86%), Gaps = 1/306 (0%)
Query: 3 MQEFNITQTYLKFLEEDSEMTMPIAAIEALVTMLKVKNPKTSAEMIKSTKLAIEELTTSI 62
M EFNIT+TYL+FLEED+EMTMPIAAIEALVT+L++K P+T+AEMI + K + EEL SI
Sbjct: 1 MSEFNITETYLRFLEEDTEMTMPIAAIEALVTLLRIKTPETAAEMINTIKSSTEELIKSI 60
Query: 63 PNSISLRAGCDIFMRFVLKNTHLYGDWENCQQHLIENGHLFVSRAKQSRDRIAEXXXXXX 122
PNS+SLRAGCDIFMRFVL+N HLYGDWENC+QHLIENG LFVSRAK+SR++IAE
Sbjct: 61 PNSVSLRAGCDIFMRFVLRNLHLYGDWENCKQHLIENGQLFVSRAKKSRNKIAEIGVDFI 120
Query: 123 XXXXXXLVHGFSRAVFSLLSHAAEKLIRFRCIVTESRPSGQGLQLYHLLKKKGIPVTMIV 182
LVHG+SRAVFSLL+HAA K IRFRC+VTESRPS QG QLY LL++KGIPVT+IV
Sbjct: 121 ADDDIILVHGYSRAVFSLLNHAANKFIRFRCVVTESRPSKQGNQLYTLLEQKGIPVTLIV 180
Query: 183 DNAVGTIIHKVNKIFVGAEGVAESGGIINLVGTYSIGVLAKNARKPFYVVSESHKFVRMF 242
D+AVG +I KV+K+FVGAEGVAESGGIINLVGTYS+GVLA NARKPFYVV+ESHKFVRMF
Sbjct: 181 DSAVGAVIDKVDKVFVGAEGVAESGGIINLVGTYSVGVLAHNARKPFYVVTESHKFVRMF 240
Query: 243 PLSSDDIPMERDPLDFSKNGIEDDEEPLSGPSVDFTSQEYITALITDLGGLTPSAVSEEL 302
PLSSDD+PM PLDF++ +D E+ L GP++D+T+QEYITALITDLG LTPSAVSEEL
Sbjct: 241 PLSSDDLPMAGPPLDFTRR-TDDLEDALRGPTIDYTAQEYITALITDLGVLTPSAVSEEL 299
Query: 303 IKMWYD 308
IKMWYD
Sbjct: 300 IKMWYD 305
>SPCC11E10.07c [J] KOG1466 Translation initiation factor 2B alpha subunit
(eIF-2Balpha/GCN3)
Length = 341
Score = 272 bits (696), Expect = 4e-73
Identities = 147/325 (45%), Positives = 202/325 (61%), Gaps = 23/325 (7%)
Query: 5 EFNITQTYLKFLEEDSEMTMPIAAIEALVTMLKVKNPKTSAEMIKSTKLAIEELTTSIPN 64
EF+I Q Y KFL++D E+TMP+AAIEALV +L KT +E + + L + N
Sbjct: 16 EFDIVQVYKKFLQDDPEITMPVAAIEALVQLLSRSQAKTISEFMDILQNGSNTLKEGVQN 75
Query: 65 SISLRAGCDIFMRFVLKNTHLYGDWENCQQHLIENGHLFVSRAKQSRDRIAEXXXXXXXX 124
+ISL AGCDIF RFV ++ H GD+E C++HL+ENG LF+ RA+ R RIA
Sbjct: 76 NISLSAGCDIFQRFVTRSLHDVGDFEQCKRHLVENGKLFIQRARACRQRIAHLGYPLIRD 135
Query: 125 XXXXLVHGFSRAVFSLLSHAAEKLIRFRCIVTESRPSGQGLQLYHLLKKKGIPVTMIVDN 184
L HGFSR V ++L AA++ +RF+ VTESRPSG G + LK IP M++D+
Sbjct: 136 GSVILTHGFSRGVAAVLLAAAKRHVRFKVFVTESRPSGSGCLMTRTLKNACIPTCMVLDS 195
Query: 185 AVGTIIHKVNKIFVGAEGVAESGGIINLVGTYSIGVLAKNARKPFYVVSESHKFVRMFPL 244
AV +++V+ + VGAEGV E+GG+IN +GT+ + V AK+A KPFY V+ESHKFVRMFPL
Sbjct: 196 AVSFTMNRVDLVLVGAEGVVENGGLINQIGTFQLAVFAKHAHKPFYAVAESHKFVRMFPL 255
Query: 245 SSDDIPMERDPLDF---SKNGIEDDEEPL-------------------SGPSVDFTSQEY 282
S DIP R L+F S + + EP+ + P++D T E+
Sbjct: 256 SQYDIPFSRPILEFDDPSPETVHPEPEPIPTPSDAIHNELIMNEEQIRNNPTLDVTPPEF 315
Query: 283 ITALITDLGGL-TPSAVSEELIKMW 306
++ LITDLG + + S VSEELIK++
Sbjct: 316 VSGLITDLGIIDSKSGVSEELIKLY 340
>Hs4503503 [J] KOG1466 Translation initiation factor 2B alpha subunit
(eIF-2Balpha/GCN3)
Length = 305
Score = 204 bits (519), Expect = 1e-52
Identities = 119/308 (38%), Positives = 178/308 (57%), Gaps = 8/308 (2%)
Query: 3 MQEFNITQTYLKFLEEDSEMTMPIAAIEALVTMLKVKNPKTSAEMIKSTKLAIEELTTSI 62
M + + + + ++ED +M +AAI L+ LK +T + + AIE L +
Sbjct: 1 MDDKELIEYFKSQMKEDPDMASAVAAIRTLLEFLKRDKGETIQGLRANLTSAIETLC-GV 59
Query: 63 PNSISLRAGCDIFMRFVLKNTHLYGDWENCQQHLIENGHLFVSRAKQSRDRIAEXXXXXX 122
+S+++ +G ++F+RF+ + Y D+ C++ +IE G LF+ R SR++IA+
Sbjct: 60 DSSVAVSSGGELFLRFISLASLEYSDYSKCKKIMIERGELFLRRISLSRNKIADLCHTFI 119
Query: 123 XXXXXXLVHGFSRAVFSLLSHAAEKLIRFRCIVTESRPSGQGLQLYHLLKKKGIPVTMIV 182
L H +SR V +L A RF VTES+P G ++ L +PVT+++
Sbjct: 120 KDGATILTHAYSRVVLRVLEAAVAAKKRFSVYVTESQPDLSGKKMAKALCHLNVPVTVVL 179
Query: 183 DNAVGTIIHKVNKIFVGAEGVAESGGIINLVGTYSIGVLAKNARKPFYVVSESHKFVRMF 242
D AVG I+ K + + VGAEGV E+GGIIN +GT + V AK KPFYVV+ES KFVR+F
Sbjct: 180 DAAVGYIMEKADLVIVGAEGVVENGGIINKIGTNQMAVCAKAQNKPFYVVAESFKFVRLF 239
Query: 243 PLSSDDIP----MERDPLDFSKNGIEDDEEPLSGPSVDFTSQEYITALITDLGGLTPSAV 298
PL+ D+P + D L ++ G + EE P VD+T+ IT L TDLG LTPSAV
Sbjct: 240 PLNQQDVPDKFKYKADTLKVAQTGQDLKEE---HPWVDYTAPSLITLLFTDLGVLTPSAV 296
Query: 299 SEELIKMW 306
S+ELIK++
Sbjct: 297 SDELIKLY 304
>At1g72340 [J] KOG1466 Translation initiation factor 2B alpha subunit
(eIF-2Balpha/GCN3)
Length = 362
Score = 190 bits (483), Expect = 2e-48
Identities = 110/305 (36%), Positives = 176/305 (57%), Gaps = 6/305 (1%)
Query: 4 QEFNITQTYLKFLEEDSEMTMPIAAIEALVTMLKVKNPKTSAEMIKSTKLAIEELTTSIP 63
+ FN+ + + + ++ ++ +AAI AL +++ T E+ K A + L +
Sbjct: 61 KSFNVIEEFNNWRKQP-DLAEAVAAIRALAAVIRASEASTMMELEIELKKASDTLKSWDK 119
Query: 64 NSISLRAGCDIFMRFVLKNTHL-YGDWENCQQHLIENGHLFVSRAKQSRDRIAEXXXXXX 122
SISL AGCD+F+R+V + + L Y D+ + + L+E F + ++R IA
Sbjct: 120 TSISLTAGCDLFIRYVTRTSALEYEDFNSAKSRLLERAEKFGEISCKARRIIAMLSQDFI 179
Query: 123 XXXXXXLVHGFSRAVFSLLSHAAEKLIRFRCIVTESRPSGQGLQLYHLLKKKGIPVTMIV 182
LVHG SR V +L AA+ FR + TE RP G G+ L L K IPV +++
Sbjct: 180 FDGCTILVHGLSRVVLEILKTAAQNNKLFRVLCTEGRPDGTGVLLSSELSKLDIPVKLLL 239
Query: 183 DNAVGTIIHKVNKIFVGAEGVAESGGIINLVGTYSIGVLAKNARKPFYVVSESHKFVRMF 242
D+AV + +V+ +FVGA+GV ESGGIIN++GTY I ++A + KP YV +ES+KF R++
Sbjct: 240 DSAVAYSMDEVDMVFVGADGVVESGGIINMMGTYQIALVAHSMNKPVYVAAESYKFARLY 299
Query: 243 PLSSDDIPMERDPLDFSKNGIE-DDEEPLSGPSVDFTSQEYITALITDLGGLTPSAVSEE 301
PL D+ P++F G++ + + + D+T +Y+T L TDLG L+PS VS+E
Sbjct: 300 PLDQKDMAPALRPIEF---GVKIPTKVEVERSARDYTPPQYLTLLFTDLGVLSPSVVSDE 356
Query: 302 LIKMW 306
LI+++
Sbjct: 357 LIQLY 361
>7301868 [J] KOG1466 Translation initiation factor 2B alpha subunit
(eIF-2Balpha/GCN3)
Length = 306
Score = 180 bits (456), Expect = 3e-45
Identities = 106/306 (34%), Positives = 174/306 (56%), Gaps = 12/306 (3%)
Query: 4 QEFNITQTYLKFLEEDSEMTMPIAAIEALVTMLKVKNPKTSAEMIKSTKLAIEELTTSIP 63
Q+F++ + +L+ L+ED +++ IAAI L+ +L+ K T + + + A+ + +
Sbjct: 9 QDFDVVKYFLQLLDEDKDLSSGIAAIRTLLMILEKKQFGTIHILHTTMREAVAAMRNTDL 68
Query: 64 NSISLRAGCDIFMRFV---LKNTHLYGDWENCQQHLIENGHLFVSRAKQSRDRIAEXXXX 120
+ ++ + ++F RF+ L + H+ E C+Q ++ G +F+++ SR IA+
Sbjct: 69 SIAAIVSAGELFCRFITLSLDDKHM----EECRQIMLNRGKIFLTKLLNSRQVIAQQAQR 124
Query: 121 XXXXXXXXLVHGFSRAVFSLLSHAAEKLIRFRCIVTESRPSGQGLQLYHLLKKKGIPVTM 180
L H SR V L A++ F VT+ G ++ L GI T+
Sbjct: 125 FITDGCRILTHSRSRVVLKALITASQNKKSFHVYVTQGGTGNSGEEMVKDLHAAGIDCTL 184
Query: 181 IVDNAVGTIIHKVNKIFVGAEGVAESGGIINLVGTYSIGVLAKNARKPFYVVSESHKFVR 240
I+D+A G ++ V+ + VGAE V ESGGIIN +GTY++G+ A+ +KPFYV++ES KF R
Sbjct: 185 ILDSATGYVMESVDFVLVGAEAVVESGGIINRIGTYTMGLCAREMKKPFYVLAESFKFSR 244
Query: 241 MFPLSSDDIPMERDPLDFSKNGIEDDEEPLSGPSVDFTSQEYITALITDLGGLTPSAVSE 300
++PL+ D+P E +S+ + D + P VD+T YIT L TDLG LTPSAVS+
Sbjct: 245 LYPLNQRDLPNE---YKYSRKHLNDVSK--VHPLVDYTPPVYITLLFTDLGRLTPSAVSD 299
Query: 301 ELIKMW 306
ELIK++
Sbjct: 300 ELIKLY 305
>CE00367 [J] KOG1466 Translation initiation factor 2B alpha subunit
(eIF-2Balpha/GCN3)
Length = 305
Score = 175 bits (443), Expect = 8e-44
Identities = 101/307 (32%), Positives = 161/307 (51%), Gaps = 6/307 (1%)
Query: 3 MQEFNITQTYLKFLEEDSEMTMPIAAIEALVTMLKVKNPKTSAEMIKSTKLAIEELTTSI 62
M + +I ++ LE D + +A +E L+ +L T AE + L +
Sbjct: 1 MVQESIISSFRGKLENDPSKSTSLATVETLLEVLDRSRATTVAEFQNELNQVVAALEKTD 60
Query: 63 PNSISLRAGCDIFMRFVLKNTHLYGDWENCQQHLI---ENGHLFVSRAKQSRDRIAEXXX 119
+S S+R+ D+F RF D E+ Q L + F+ + SR +I++
Sbjct: 61 YSSTSIRSAADLFTRFTSLAPAALLDQEDFSQVLDLYRQRARSFIKNVRGSRAKISKCAR 120
Query: 120 XXXXXXXXXLVHGFSRAVFSLLSHAAEKLIRFRCIVTESRPSGQGLQLYHLLKKKGIPVT 179
L H +S+ V + A + VTES+P G ++ LKK G+P T
Sbjct: 121 LFFTHHMNILTHSYSKVVLETILDAHKSGYHLHVWVTESQPDASGKLVFEELKKNGVPTT 180
Query: 180 MIVDNAVGTIIHKVNKIFVGAEGVAESGGIINLVGTYSIGVLAKNARKPFYVVSESHKFV 239
+++D+ VG ++ ++ + VGAEGV E+GGIIN +GT ++ ++AK+ P YV +E+ KFV
Sbjct: 181 LVLDSCVGYVMERIQAVLVGAEGVMETGGIINKIGTVNVCIIAKSRHVPVYVCAETIKFV 240
Query: 240 RMFPLSSDDIPMERDPLDFSKNGIEDDEEPLSGPSVDFTSQEYITALITDLGGLTPSAVS 299
R FPL+ DIP E + + IE + L P VD+T+ E++T +ITD+G + P AV
Sbjct: 241 REFPLNQADIPQE---FKYRTSVIERNNLELEHPDVDYTAPEFLTLIITDVGAMKPEAVG 297
Query: 300 EELIKMW 306
EELIKM+
Sbjct: 298 EELIKMY 304
>At1g53900_2 [J] KOG1466 Translation initiation factor 2B alpha subunit
(eIF-2Balpha/GCN3)
Length = 402
Score = 169 bits (428), Expect = 5e-42
Identities = 98/243 (40%), Positives = 146/243 (59%), Gaps = 10/243 (4%)
Query: 65 SISLRAGCDIFMRFVLKNTHL-YGDWENCQQHLIENGHLFVSRAKQSRDRIAEXXXXXXX 123
SISL AGCD+FMR+V + + L + D+ + + ++E F + ++R IA
Sbjct: 168 SISLTAGCDLFMRYVTRTSALEFEDFNSAKSRVLERAEKFGEISCKARTIIAMLSQDFIF 227
Query: 124 XXXXXLVHGFSRAVFSLLSHAAEKLIRFRCIVTESRPSGQGLQLYHLLKKKGIPVTMIVD 183
LVHGFSR VF +L +A+ FR + T G+ L + L K IPV +++D
Sbjct: 228 DGCTILVHGFSRVVFEILKTSAQNKKLFRVLCT-------GVLLANELAKLDIPVKLLID 280
Query: 184 NAVGTIIHKVNKIFVGAEGVAESGGIINLVGTYSIGVLAKNARKPFYVVSESHKFVRMFP 243
+AV + +V+ +FVGA+GV ESGGIIN++GTY I ++A++ KP YV +ES+KF R++P
Sbjct: 281 SAVAYSMDEVDMVFVGADGVVESGGIINMMGTYQIALVAQSMNKPVYVAAESYKFARLYP 340
Query: 244 LSSDDIPMERDPLDFSKNGIEDDEEPLSGPSVDFTSQEYITALITDLGGLTPSAVSEELI 303
L D+ P+DFS E S + D+T +Y+T L TDLG LTPS VS+ELI
Sbjct: 341 LDQKDLEPALRPIDFSVPVPPKVEVERS--ARDYTPPQYLTLLFTDLGVLTPSVVSDELI 398
Query: 304 KMW 306
+++
Sbjct: 399 QLY 401
>At1g53880_2 [J] KOG1466 Translation initiation factor 2B alpha subunit
(eIF-2Balpha/GCN3)
Length = 402
Score = 169 bits (428), Expect = 5e-42
Identities = 98/243 (40%), Positives = 146/243 (59%), Gaps = 10/243 (4%)
Query: 65 SISLRAGCDIFMRFVLKNTHL-YGDWENCQQHLIENGHLFVSRAKQSRDRIAEXXXXXXX 123
SISL AGCD+FMR+V + + L + D+ + + ++E F + ++R IA
Sbjct: 168 SISLTAGCDLFMRYVTRTSALEFEDFNSAKSRVLERAEKFGEISCKARTIIAMLSQDFIF 227
Query: 124 XXXXXLVHGFSRAVFSLLSHAAEKLIRFRCIVTESRPSGQGLQLYHLLKKKGIPVTMIVD 183
LVHGFSR VF +L +A+ FR + T G+ L + L K IPV +++D
Sbjct: 228 DGCTILVHGFSRVVFEILKTSAQNKKLFRVLCT-------GVLLANELAKLDIPVKLLID 280
Query: 184 NAVGTIIHKVNKIFVGAEGVAESGGIINLVGTYSIGVLAKNARKPFYVVSESHKFVRMFP 243
+AV + +V+ +FVGA+GV ESGGIIN++GTY I ++A++ KP YV +ES+KF R++P
Sbjct: 281 SAVAYSMDEVDMVFVGADGVVESGGIINMMGTYQIALVAQSMNKPVYVAAESYKFARLYP 340
Query: 244 LSSDDIPMERDPLDFSKNGIEDDEEPLSGPSVDFTSQEYITALITDLGGLTPSAVSEELI 303
L D+ P+DFS E S + D+T +Y+T L TDLG LTPS VS+ELI
Sbjct: 341 LDQKDLEPALRPIDFSVPVPPKVEVERS--ARDYTPPQYLTLLFTDLGVLTPSVVSDELI 398
Query: 304 KMW 306
+++
Sbjct: 399 QLY 401
>At5g38640 [J] KOG1467 Translation initiation factor 2B delta subunit
(eIF-2Bdelta/GCD2)
Length = 642
Score = 84.7 bits (208), Expect = 2e-16
Identities = 59/181 (32%), Positives = 89/181 (48%), Gaps = 11/181 (6%)
Query: 129 LVHGFSRAVFSLLSHAAEKLIRFRCIVTESRPSGQGLQLYHLLKKKGIPVTMIVDNAVGT 188
L +G AV ++ HA E +FR +V +SRP +G L L K+GI T NA+
Sbjct: 448 LTYGSPTAVEMVILHAHELRKKFRVLVVDSRPKLEGQLLLRRLIKRGINCTYTHINAISY 507
Query: 189 IIHKVNKIFVGAEGVAESGGIINLVGTYSIGVLAKNARKPFYVVSESHKFVRMFPLSSDD 248
I+H+V K+F+GA V +G + + VGT + ++A R P V E++KF L S
Sbjct: 508 IMHEVTKVFLGASSVLSNGTVYSRVGTACVAMVANAFRVPVLVCCEAYKFHERVQLDSIC 567
Query: 249 IPMERDPLDFSKNGIEDDEEPLSGPS-----------VDFTSQEYITALITDLGGLTPSA 297
DP S+ +D L G + D T +YI+ +ITD G + P++
Sbjct: 568 SNELGDPNAISEVHGREDINYLDGLTNNANLQFLNLMYDATPSDYISMIITDYGMVPPTS 627
Query: 298 V 298
V
Sbjct: 628 V 628
>At2g44070 [J] KOG1467 Translation initiation factor 2B delta subunit
(eIF-2Bdelta/GCD2)
Length = 307
Score = 82.8 bits (203), Expect = 6e-16
Identities = 60/182 (32%), Positives = 88/182 (47%), Gaps = 12/182 (6%)
Query: 129 LVHGFSRAVFSLLSHAAEKLIRFRCIVTESRPSGQGLQLYHLLKKKGIPVTMIVDNAVGT 188
L +G S + +L HA E +FR V +SRP QG L L K+GI T A+
Sbjct: 106 LTYGSSTVIEMILVHAHELGKKFRVFVVDSRPKLQGKLLLRRLIKRGINCTYTHITAISY 165
Query: 189 IIHKVNKIFVGAEGVAESGGIINLVGTYSIGVLAKNARKPFYVVSESHKFVRMFPLSSDD 248
I+H+V K+F+GA V +G + + VGT + ++A R P V E++KF L
Sbjct: 166 IMHQVTKVFLGASSVFSNGTVYSRVGTACVAMVANAFRVPVLVCCEAYKFHEKVQLDYSI 225
Query: 249 IPME-RDPLDFSKNGIEDDEEPLSGPS-----------VDFTSQEYITALITDLGGLTPS 296
E DP SK +D L+G + D T +YI+ +ITD G + P+
Sbjct: 226 CSNELGDPNAISKVHGREDINYLNGLTNNAKLKFLNLMYDATPSDYISMIITDYGMVPPT 285
Query: 297 AV 298
+V
Sbjct: 286 SV 287
>Hs7657058 [J] KOG1465 Translation initiation factor 2B beta subunit
(eIF-2Bbeta/GCD7)
Length = 351
Score = 82.0 bits (201), Expect = 1e-15
Identities = 56/218 (25%), Positives = 103/218 (46%), Gaps = 5/218 (2%)
Query: 93 QQHLIENGHLFVSRAKQSRDRIAEXXXXXXXXXXXXLVHGFSRAVFSLLSHAAEKLIRFR 152
Q ++IE + + + + + IA + GFSR V + L AA K +F
Sbjct: 130 QSNIIEAINELLVELEGTMENIAAQALEHIHSNEVIMTIGFSRTVEAFLKEAARKR-KFH 188
Query: 153 CIVTESRPSGQGLQLYHLLKKKGIPVTMIVDNAVGTIIHKVNKIFVGAEGVAESGGIINL 212
IV E P QG ++ L K GI T++ D A+ ++ +VNK+ +G + + +G + +
Sbjct: 189 VIVAECAPFCQGHEMAVNLSKAGIETTVMTDAAIFAVMSRVNKVIIGTKTILANGALRAV 248
Query: 213 VGTYSIGVLAKNARKPFYVVSESHKFVRMFPLSSDD---IPMERDPLDFSKNGIEDDEEP 269
GT+++ + AK+ P V + K FP D + L F++ I ++
Sbjct: 249 TGTHTLALAAKHHSTPLIVCAPMFKLSPQFPNEEDSFHKFVAPEEVLPFTEGDIL-EKVS 307
Query: 270 LSGPSVDFTSQEYITALITDLGGLTPSAVSEELIKMWY 307
+ P D+ E IT I+++GG PS + + ++++
Sbjct: 308 VHCPVFDYVPPELITLFISNIGGNAPSYIYRLMSELYH 345
>At3g07300 [J] KOG1465 Translation initiation factor 2B beta subunit
(eIF-2Bbeta/GCD7)
Length = 384
Score = 81.3 bits (199), Expect = 2e-15
Identities = 60/204 (29%), Positives = 90/204 (43%), Gaps = 10/204 (4%)
Query: 96 LIENGHLFVSRAKQSRDRIAEXXXXXXXXXXXXLVHGFSRAVFSLLSHAAEKLIRFRCIV 155
+IE + + ++IAE L G SR V L A EK FR V
Sbjct: 180 VIEGVNQLIQEIAGCHEQIAEQAIEHIHQNEVILTLGSSRTVLEFLCAAKEKKRSFRVFV 239
Query: 156 TESRPSGQGLQLYHLLKKKGIPVTMIVDNAVGTIIHKVNKIFVGAEGVAESGGIINLVGT 215
E P QG L L +G+ T+I D+AV +I +VN + +GA V +GG+I VG
Sbjct: 240 AEGAPRYQGHLLAKELVARGLQTTVITDSAVFAMISRVNMVIIGAHAVMANGGVIGPVGV 299
Query: 216 YSIGVLAKNARKPFYVVSESHKFVRMFPLSSDDIPME-RDP---LDFSK------NGIED 265
+ A+ PF V++ SHK ++P + + + E R P LDF + G
Sbjct: 300 NMAALAAQKHAVPFVVLAGSHKLCPLYPHNPEVLLNELRSPSELLDFGEFSDCLDFGAGS 359
Query: 266 DEEPLSGPSVDFTSQEYITALITD 289
+ P+ D+ ++ ITD
Sbjct: 360 GSLQVVNPTFDYVPPNLVSLFITD 383
>SPBC23E6.10c [J] KOG1468 Predicted translation initiation factor related to
eIF-2B alpha/beta/delta subunits (CIG2/IDI2)
Length = 359
Score = 73.6 bits (179), Expect = 3e-13
Identities = 74/312 (23%), Positives = 130/312 (40%), Gaps = 56/312 (17%)
Query: 26 IAAIEALVTMLKVKNPKTSAEMIKSTKLAIEELTTSIPNSISLRAGCDIFMRFVLKNTHL 85
IA + AL + +K+ A+ + + E L S P +++L L+
Sbjct: 51 IAIVAALSVAVGLKHLSEDADAKEYVINSFEHLKQSRPTAVNLFETAKFMQGIALQ---- 106
Query: 86 YGDWENCQQHLIEN------------------GHLFVSRAKQSRDRIAEXXXXXXXXXXX 127
+ +NC+ +I+ G F+ + + +D++
Sbjct: 107 --EGKNCRNKIIQEAERMLVKDLEDNHNIGTAGRKFLLQHYKDKDKLTVLTHCNTGSLAT 164
Query: 128 XLVHGFSRAVFSLLS-HAAEKLIRFRCIVTESRPSGQGLQL--YHLLKKKGIPVTMIVDN 184
G+ A+ + S H + L C TE+RP QG +L + L+ K IP T++ D+
Sbjct: 165 S---GYGTALGIIRSLHESGNLEHAYC--TETRPYNQGSRLTAFELVHDK-IPATLVTDS 218
Query: 185 AVGTIIHKVNKIFVGAEGVAESGGIINLVGTYSIGVLAKNARKPFYVVSESHKFVRMFPL 244
V +I+HK++ I VGA+ V +G N +GTY++ +LAK+ KPF +V+ +
Sbjct: 219 TVASIMHKIDAIVVGADRVTRNGDTANKIGTYNLAILAKHFGKPF-IVAAPFSSIDTSLA 277
Query: 245 SSDDIPMERDP------------LDFSKNGIEDDEE----------PLSGPSVDFTSQEY 282
S I +E+ P D + +ED + + P+ D T
Sbjct: 278 SGSQITIEQRPPIEMTTITGPIITDSNSRNLEDPKRVRISIAAPGIDVYSPAFDVTPANL 337
Query: 283 ITALITDLGGLT 294
ITA+ T+ G T
Sbjct: 338 ITAIATEKGFYT 349
>7302052 [J] KOG1468 Predicted translation initiation factor related to
eIF-2B alpha/beta/delta subunits (CIG2/IDI2)
Length = 364
Score = 71.2 bits (173), Expect = 2e-12
Identities = 50/157 (31%), Positives = 76/157 (47%), Gaps = 8/157 (5%)
Query: 156 TESRPSGQGLQL--YHLLKKKGIPVTMIVDNAVGTIIHKVN--KIFVGAEGVAESGGIIN 211
TE+RP QG +L Y L+ +K P T+++D+ V ++ N + VGA+ VA +G N
Sbjct: 206 TETRPYNQGARLTAYELVHEK-FPATLVLDSMVAALLRAKNVAAVVVGADRVASNGDTAN 264
Query: 212 LVGTYSIGVLAKNARKPFYVVSESHKFVRMFPLSSDDIPMERDPLDFSKNGIEDDEEP-- 269
+GTY I V+AK+ PFYV + P I ER + + G P
Sbjct: 265 KIGTYQIAVVAKHHDVPFYVAAPLTSIDLAIPGGDHIIIEERPDREMTHVGEHRIAAPGI 324
Query: 270 -LSGPSVDFTSQEYITALITDLGGLTPSAVSEELIKM 305
P+ D T IT +IT+ G P+ + E + K+
Sbjct: 325 NCWNPAFDVTPASLITGIITERGVFKPAELKEAITKL 361
>7291571 [J] KOG1467 Translation initiation factor 2B delta subunit
(eIF-2Bdelta/GCD2)
Length = 626
Score = 71.2 bits (173), Expect = 2e-12
Identities = 49/178 (27%), Positives = 83/178 (46%), Gaps = 9/178 (5%)
Query: 129 LVHGFSRAVFSLLSHAAEKLIRFRCIVTESRPSGQGLQLYHLLKKKGIPVTMIVDNAVGT 188
L S + + A + + FR IV +SRP +G +L L GIP T ++ NAVG
Sbjct: 438 LTFACSSLIQFICEEAKRRQVAFRVIVVDSRPGCEGQELLRRLHATGIPCTYVLINAVGY 497
Query: 189 IIHKVNKIFVGAEGVAESGGIINLVGTYSIGVLAKNARKPFYVVSESHKFVRMF------ 242
++ + K+ +GA + +G ++ GT + ++A P V E+HKF F
Sbjct: 498 VMAEATKVLLGAHALLANGYVMARTGTAQVALVANAHNVPVLVCCETHKFSERFQTDAIV 557
Query: 243 --PLSSDDIPMERDPLDFSKNGIEDDEEPLSGPSVDFTSQEYITALITDLGGLTPSAV 298
LS + + D S + PL+ S D T E ++A++T++ L ++V
Sbjct: 558 YNELSDPNQLVRGDKCQLSNWAAKGKLLPLN-LSYDITPPELVSAVVTEVAILPCTSV 614
>7290350 [J] KOG1465 Translation initiation factor 2B beta subunit
(eIF-2Bbeta/GCD7)
Length = 352
Score = 70.1 bits (170), Expect = 4e-12
Identities = 49/181 (27%), Positives = 84/181 (46%), Gaps = 2/181 (1%)
Query: 129 LVHGFSRAVFSLLSHAAEKLIRFRCIVTESRPSGQGLQLY-HLLKKKGIPVTMIVDNAVG 187
L G SR+V + L A +K IV E P+ +G L L +K + + +I D A+
Sbjct: 166 LTLGHSRSVENFLKRAIKKRQFLTIIVAECAPACRGHNLAASLANEKNVEIVVIPDAAIF 225
Query: 188 TIIHKVNKIFVGAEGVAESGGIINLVGTYSIGVLAKNARKPFYVVSESHKFVRMFPLSSD 247
++ +VNK+ +G V +GG+ G Y++ + AK+ P V++ +K + D
Sbjct: 226 AMMSRVNKVIIGTHSVLANGGLRAACGAYTVALAAKHYSVPVIVLAPMYKLSPLHLCEQD 285
Query: 248 DIPMERDPLD-FSKNGIEDDEEPLSGPSVDFTSQEYITALITDLGGLTPSAVSEELIKMW 306
M D + I E + P D+ E +T I++ GG PS V L +++
Sbjct: 286 AFNMVGCAEDVIPYDSIPAREAKVYSPMFDYVPPELVTLFISNTGGHAPSYVYRLLTELY 345
Query: 307 Y 307
+
Sbjct: 346 H 346
>At1g48970 [J] KOG1467 Translation initiation factor 2B delta subunit
(eIF-2Bdelta/GCD2)
Length = 756
Score = 69.3 bits (168), Expect = 7e-12
Identities = 51/187 (27%), Positives = 84/187 (44%), Gaps = 12/187 (6%)
Query: 129 LVHGFSRAVFSLLSHAAEKLIRFRCIVTESRPSGQGLQLYHLLKKKGIPVTMIVDNAVGT 188
L +GFS V +L +A E +FR ++ +SRP+ +G +L L +G+ T NA+
Sbjct: 556 LTYGFSCVVEMILLYAHEIGKKFRVVIVDSRPNLEGQKLLRRLVTRGLDCTYTHINAISY 615
Query: 189 IIHKVNKIFVGAEGVAESGGIINLVGTYSIGVLAKNARKPFYVVSESHKFVRMFPLSS-- 246
I+ + ++F+GA + +G + VGT I ++A P V E++KF L S
Sbjct: 616 IMREATRVFLGASSIYSNGTLYARVGTSCIAMVANAFSVPVIVCCEAYKFHERVLLDSIC 675
Query: 247 ----------DDIPMERDPLDFSKNGIEDDEEPLSGPSVDFTSQEYITALITDLGGLTPS 296
+IP R SK + D T EYI+ +++D G
Sbjct: 676 SNELGDPDAVANIPSFRTNAKHSKTMDNNKNLQFLNLMYDSTPSEYISMIVSDYGMSNFH 735
Query: 297 AVSEELI 303
VS+ +
Sbjct: 736 LVSDTFV 742
>SPAC343.14c [J] KOG1465 Translation initiation factor 2B beta subunit
(eIF-2Bbeta/GCD7)
Length = 393
Score = 66.6 bits (161), Expect = 4e-11
Identities = 48/173 (27%), Positives = 81/173 (46%), Gaps = 7/173 (4%)
Query: 129 LVHGFSRAVFSLLSHAAEKLIRFRCIVTESRPSGQ--GLQLYHLLKKKGIPVTMIVDNAV 186
L G S+ V + L AA+K +F IV E P+ Q + L + GI T+I D +
Sbjct: 206 LTQGCSKTVEAFLRFAAKKR-KFSVIVAEGFPNNQKGSHAMAKRLAQAGIDTTVISDATI 264
Query: 187 GTIIHKVNKIFVGAEGVAESGGIINLVGTYSIGVLAKNARKPFYVVSESHKFVRMFPLSS 246
I+ +VNK+ +G + +GG++ G + A++ P V S +K ++P
Sbjct: 265 FAIMSRVNKVILGTHAILGNGGLVTYSGAQLVAQAARHHATPVVVCSGIYKLSPVYPYDL 324
Query: 247 DDIPMERDP---LDFSKNGIEDDEEPLSGPSVDFTSQEYITALITDLGGLTPS 296
+ I P + F++ + E L+ P D+ + + IT+LGG PS
Sbjct: 325 ESIIQLSSPDKIMSFNEGDLISRAEILN-PYYDYIPPDLVDLFITNLGGYPPS 376
>SPAC21E11.06 [J] KOG1467 Translation initiation factor 2B delta subunit
(eIF-2Bdelta/GCD2)
Length = 467
Score = 65.9 bits (159), Expect = 7e-11
Identities = 53/185 (28%), Positives = 82/185 (43%), Gaps = 16/185 (8%)
Query: 129 LVHGFSRAVFSLLSHAAEKLIRFRCIVTESRPSGQGLQLYHLLKKKGIPVTMIVDNAVGT 188
L + S V +L HA +FR +V +SRP +G LL + GI T ++ +A+
Sbjct: 272 LTYLHSSTVNDVLIHAKNVGKKFRVVVVDSRPEFEGRVCLKLLTEHGIECTYVMISALSY 331
Query: 189 IIHKVNKIFVGAEGVAESGGIINLVGTYSIGVLAKNARKPFYVVSESHKFVRMFPLSSDD 248
I+ +V KIF+G + +G + + GT I +L + P ES+KF L S
Sbjct: 332 IMQEVTKIFLGGHAMLSNGALYSRAGTSLISLLGHESNVPVIACCESYKFTERIQLDS-L 390
Query: 249 IPMERDPLDFSKN-GIEDDEE--------------PLSGPSVDFTSQEYITALITDLGGL 293
+ E P D N G++D EE L D T IT + ++G L
Sbjct: 391 VYNELAPGDQLVNMGVDDFEEKPGVLANWKSVKNLKLLSLKYDVTPPRLITVCVCEMGLL 450
Query: 294 TPSAV 298
++V
Sbjct: 451 PSTSV 455
>Hs14165262 [J] KOG1467 Translation initiation factor 2B delta subunit
(eIF-2Bdelta/GCD2)
Length = 523
Score = 65.1 bits (157), Expect = 1e-10
Identities = 47/179 (26%), Positives = 82/179 (45%), Gaps = 9/179 (5%)
Query: 129 LVHGFSRAVFSLLSHAAEKLIRFRCIVTESRPSGQGLQLYHLLKKKGIPVTMIVDNAVGT 188
LV+G S V +L A + RFR +V +SRP +G L G+P + ++ A
Sbjct: 334 LVYGCSSLVSRILQEAWTEGRRFRVVVVDSRPWLEGRHTLRSLVHAGVPASYLLIPAASY 393
Query: 189 IIHKVNKIFVGAEGVAESGGIINLVGTYSIGVLAKNARKPFYVVSESHKFVRMFPLSS-- 246
++ +V+K+ +GA + +G +++ VGT + ++A+ P V E++KF +
Sbjct: 394 VLPEVSKVLLGAHALLANGSVMSRVGTAQLALVARAHNVPVLVCCETYKFCERVQTDAFV 453
Query: 247 -------DDIPMERDPLDFSKNGIEDDEEPLSGPSVDFTSQEYITALITDLGGLTPSAV 298
DD+ +R N L D T E + +IT+LG + S+V
Sbjct: 454 SNELDDPDDLQCKRGEHVALANWQNHASLRLLNLVYDVTPPELVDLVITELGMIPCSSV 512
>CE07818 [J] KOG1468 Predicted translation initiation factor related to
eIF-2B alpha/beta/delta subunits (CIG2/IDI2)
Length = 366
Score = 62.8 bits (151), Expect = 6e-10
Identities = 46/157 (29%), Positives = 76/157 (48%), Gaps = 8/157 (5%)
Query: 155 VTESRPSGQGLQLYHLLKKKG-IPVTMIVDNAVGTII--HKVNKIFVGAEGVAESGGIIN 211
V E+RP QG++L + G +P +I D+ + H+V+ + GA+ VA +G N
Sbjct: 211 VLETRPYNQGIRLTSIELLHGEVPFKLITDSMAAWAMKNHQVDCVLTGADNVARNGDTAN 270
Query: 212 LVGTYSIGVLAKNARKPFYVVSESHKFVRMFPLSSDDIPMERDPLD--FSKNG--IEDDE 267
+GTY + VL K+ FY V + + ++I +E P NG I + E
Sbjct: 271 KIGTYMLAVLCKHHNINFYPV-VPFTTINKNIATGEEIKIEERPSAEMLRVNGVLIGNSE 329
Query: 268 EPLSGPSVDFTSQEYITALITDLGGLTPSAVSEELIK 304
P+ P+ D T IT ++TD G P + +++ K
Sbjct: 330 CPVWNPAFDVTPAHLITKILTDFGNWPPEMLEQQIPK 366
>At2g05830 [J] KOG1468 Predicted translation initiation factor related to
eIF-2B alpha/beta/delta subunits (CIG2/IDI2)
Length = 365
Score = 62.0 bits (149), Expect = 1e-09
Identities = 48/148 (32%), Positives = 75/148 (50%), Gaps = 11/148 (7%)
Query: 152 RCIVTESRPSGQGLQL--YHLLKKKGIPVTMIVDNAVGTIIH--KVNKIFVGAEGVAESG 207
R TE+RP QG +L + L+ +K IP T+I D+A ++ +V+ + VGA+ VA +G
Sbjct: 201 RAYCTETRPFNQGSRLTAFELVHEK-IPATLIADSAAAALMKDGRVDGVIVGADRVASNG 259
Query: 208 GIINLVGTYSIGVLAKNARKPFYVVSESHKFVRMFPLSSDDIPMERDP--LDFSKNGI-E 264
N +GTYS+ + AK+ PFYV + + + ER P L + G+ E
Sbjct: 260 DTANKIGTYSLALCAKHHGIPFYVAAPLTSVDLSLSSGKEIVIEERSPKELMHTHGGLGE 319
Query: 265 DDEEP---LSGPSVDFTSQEYITALITD 289
P + P+ D T E I +IT+
Sbjct: 320 RIAAPGISVWNPAFDMTPAELIAGIITE 347
>Hs22051459 [J] KOG1468 Predicted translation initiation factor related to
eIF-2B alpha/beta/delta subunits (CIG2/IDI2)
Length = 369
Score = 60.8 bits (146), Expect = 2e-09
Identities = 49/154 (31%), Positives = 75/154 (47%), Gaps = 7/154 (4%)
Query: 156 TESRPSGQGLQLYHL-LKKKGIPVTMIVDNAVGTII-HK-VNKIFVGAEGVAESGGIINL 212
TE+RP QG +L L + IP T+I D+ V + H+ V+ + VGA+ V +G N
Sbjct: 200 TETRPYNQGARLTAFELVYEQIPATLITDSMVAAAMAHRGVSAVVVGADRVVANGDTANK 259
Query: 213 VGTYSIGVLAKNARKPFYVVSESHKFVRMFPLSSDDIPMERDPLDFSK-NGIEDDEEPLS 271
VGTY + ++AK+ PFYV + S + I ER + + NG+ +
Sbjct: 260 VGTYQLAIVAKHHGIPFYVAAPSSSCDLRLETGKEIIIEERPGQELTDVNGVRIAAPGIG 319
Query: 272 --GPSVDFTSQEYIT-ALITDLGGLTPSAVSEEL 302
P+ D T + IT +IT+LG P + L
Sbjct: 320 VWNPAFDVTPHDLITGGIITELGVFAPEELRTAL 353
>YPR118w [J] KOG1468 Predicted translation initiation factor related to
eIF-2B alpha/beta/delta subunits (CIG2/IDI2)
Length = 411
Score = 58.9 bits (141), Expect = 9e-09
Identities = 49/175 (28%), Positives = 78/175 (44%), Gaps = 32/175 (18%)
Query: 157 ESRPSGQGLQL--YHLLKKKGIPVTMIVDNAVGTIIHK----VNKIFVGAEGVAESGGII 210
E+RP QG +L Y L+ K IP T+I D+++ I + FVGA+ + +G
Sbjct: 231 ETRPYNQGSRLTAYELVYDK-IPSTLITDSSIAYRIRTSPIPIKAAFVGADRIVRNGDTA 289
Query: 211 NLVGTYSIGVLAKNARKPFYVVSESHKFVRMFPLSSDDIPMERDPLDFS---------KN 261
N +GT + V+ K F+VV+ + D I ER+P +F +N
Sbjct: 290 NKIGTLQLAVICKQFGIKFFVVAPKTTIDNVTETGDDIIVEERNPEEFKVVTGTVINPEN 349
Query: 262 G---IEDDEEPLSG-------------PSVDFTSQEYITALITDLGGLTPSAVSE 300
G + + EP++G P+ D T E I +IT+ G T ++ E
Sbjct: 350 GSLILNESGEPITGKVGIAPLEINVWNPAFDITPHELIDGIITEEGVFTKNSSGE 404
>YGR083c [J] KOG1467 Translation initiation factor 2B delta subunit
(eIF-2Bdelta/GCD2)
Length = 651
Score = 54.3 bits (129), Expect = 2e-07
Identities = 40/142 (28%), Positives = 67/142 (47%), Gaps = 2/142 (1%)
Query: 129 LVHGFSRAVFSLLSHAAEKLIR-FRCIVTESRPSGQGLQLYHLLKKKGIPVTMIVDNAVG 187
+ +G S+ + LL H A L + + IV +SRP +G ++ L+ G+ V + ++
Sbjct: 401 VTYGSSKVLTELLLHNAISLKKNIKVIVVDSRPLFEGRKMAETLRNAGVNVMYALITSLD 460
Query: 188 TIIHK-VNKIFVGAEGVAESGGIINLVGTYSIGVLAKNARKPFYVVSESHKFVRMFPLSS 246
TI + V+ +F+GA + +G + + GT + + AK P V ES KF + L S
Sbjct: 461 TIFNMDVDYVFLGAHSILSNGFLYSRAGTAMLAMSAKRRNIPVLVCCESLKFSQRVQLDS 520
Query: 247 DDIPMERDPLDFSKNGIEDDEE 268
DP D E+ E
Sbjct: 521 VTFNELADPNDLVNIDYENPVE 542
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.319 0.135 0.384
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,690,258
Number of Sequences: 60738
Number of extensions: 657350
Number of successful extensions: 1612
Number of sequences better than 1.0e-05: 25
Number of HSP's better than 0.0 without gapping: 17
Number of HSP's successfully gapped in prelim test: 8
Number of HSP's that attempted gapping in prelim test: 1570
Number of HSP's gapped (non-prelim): 26
length of query: 308
length of database: 30,389,216
effective HSP length: 106
effective length of query: 202
effective length of database: 23,950,988
effective search space: 4838099576
effective search space used: 4838099576
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)