ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactVI3764 good R KOG3187 General function prediction only Protein tyrosine phosphatase-like protein PTPLA (contains Pro instead of catalytic Arg)
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactVI3764 1309358 1309999 214
(214 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YJL097w [R] KOG3187 Protein tyrosine phosphatase-like protein PT... 268 3e-72
Hs22043752 [R] KOG3187 Protein tyrosine phosphatase-like protein... 127 9e-30
SPBC19C2.15c [R] KOG3187 Protein tyrosine phosphatase-like prote... 127 1e-29
Hs18104976 [R] KOG3187 Protein tyrosine phosphatase-like protein... 122 4e-28
CE13650 [R] KOG3187 Protein tyrosine phosphatase-like protein PT... 121 6e-28
7297898 [R] KOG3187 Protein tyrosine phosphatase-like protein PT... 121 8e-28
Hs20549562 [R] KOG3187 Protein tyrosine phosphatase-like protein... 84 1e-16
Hs7705459 [R] KOG3187 Protein tyrosine phosphatase-like protein ... 83 2e-16
7298067 [R] KOG3187 Protein tyrosine phosphatase-like protein PT... 71 1e-12
ECU05g1430 [R] KOG3187 Protein tyrosine phosphatase-like protein... 64 2e-10
>YJL097w [R] KOG3187 Protein tyrosine phosphatase-like protein PTPLA
(contains Pro instead of catalytic Arg)
Length = 217
Score = 268 bits (686), Expect = 3e-72
Identities = 131/208 (62%), Positives = 165/208 (78%), Gaps = 2/208 (0%)
Query: 1 MASSKASIFSFLPLYNLLSASAWAYVLYQVVTLYPKIGQPSFFIATKDLVTYVQCGAIIE 60
M+ AS SFLPLYNLLSA W+Y+LY V++LYPK+GQP+FF TK++ T VQCGAIIE
Sbjct: 1 MSKKLASPLSFLPLYNLLSAVGWSYLLYLVISLYPKVGQPAFFYQTKNVATLVQCGAIIE 60
Query: 61 VTNSLFGIVRAPLVTTAAQVASRLLVVIGIFQYVPEAENAHKIYYITLLSAWCIAEIVRY 120
+ NS G+VR+PL+TT AQV+SRLLVV+GIFQ +P + YI+LL AW I EIVRY
Sbjct: 61 IINSFLGVVRSPLLTTVAQVSSRLLVVLGIFQLLPNTSGVQSVVYISLLLAWSITEIVRY 120
Query: 121 MFYFFNLVAQ--APTVLVVLRYNMFYVLYPLGVGSELFIIYSALPLAEAKYNILYKYFLI 178
++YFF LV + AP +L++LRYN+F++LYP GV SEL IIY AL AE++Y++LYK LI
Sbjct: 121 LYYFFMLVFKNGAPKILILLRYNLFWILYPTGVASELRIIYCALNAAESQYSLLYKRILI 180
Query: 179 AGMLAYIPGFPVLFSHMVAQRRKVMRSL 206
A MLAYIPGFP+LF HMVAQR+KVM+SL
Sbjct: 181 AAMLAYIPGFPMLFLHMVAQRKKVMKSL 208
>Hs22043752 [R] KOG3187 Protein tyrosine phosphatase-like protein PTPLA
(contains Pro instead of catalytic Arg)
Length = 254
Score = 127 bits (320), Expect = 9e-30
Identities = 72/215 (33%), Positives = 116/215 (53%), Gaps = 15/215 (6%)
Query: 10 SFLPLYNLLSASAWAYVLYQVVTLYPKIGQ-PSFFIATKDLVTYVQCGAIIEVTNSLFGI 68
++L +YN++ + W + +V Y G S + + + + + Q GA++E+ + GI
Sbjct: 40 AYLVIYNVVMTAGWLVIAVGLVRAYLAKGSYHSLYYSIEKPLKFFQTGALLEILHCAIGI 99
Query: 69 VRAPLVTTAAQVASRLLVVIGIFQYVPEAENAHKIYYITLLSAWCIAEIVRYMFYFFNLV 128
V + +V T+ QV SR+ ++ + V E ++ + + AW I EI+RY FY F+L+
Sbjct: 100 VPSSVVLTSFQVMSRVFLIWAVTHSVKEVQSEDSVLLFVI--AWTITEIIRYSFYTFSLL 157
Query: 129 AQAPTVLVVLRYNMFYVLYPLGVGSELFIIYSALPLAEA----------KYNILYKY--F 176
P ++ RY +F VLYP+GV EL IY+ALP KYN + Y F
Sbjct: 158 NHLPYLIKWARYTLFIVLYPMGVSGELLTIYAALPFVRQAGLYSISLPNKYNFSFDYYAF 217
Query: 177 LIAGMLAYIPGFPVLFSHMVAQRRKVMRSLNGDKR 211
LI M++YIP FP L+ HM+ QRRK++ K+
Sbjct: 218 LILIMISYIPIFPQLYFHMIHQRRKILSHTEEHKK 252
>SPBC19C2.15c [R] KOG3187 Protein tyrosine phosphatase-like protein PTPLA
(contains Pro instead of catalytic Arg)
Length = 208
Score = 127 bits (319), Expect = 1e-29
Identities = 79/205 (38%), Positives = 114/205 (55%), Gaps = 9/205 (4%)
Query: 4 SKASIFSFLPLYNLLSASAWAYVLYQVVTLYPKIGQPSF-FIATKDLVTYVQCGAIIEVT 62
SK +L LYN++S W VL + ++ + F T LV +VQ AI EV
Sbjct: 2 SKILKIQYLKLYNVISCFLWMSVLLRTGLIWGITKDTAVVFHETNTLVRWVQTLAIAEVF 61
Query: 63 NSLFGIVRAPLVTTAAQVASRLLVVIGI---FQYVPEAENAHKIYYITLLSAWCIAEIVR 119
+S+FG+V + +TT QVASRL +V G+ F YV E Y++++ AW I EI+R
Sbjct: 62 HSIFGLVSSSPLTTIIQVASRLYLVWGVCYPFSYVIEGSPI----YLSMIIAWSITEIIR 117
Query: 120 YMFYFFNLVAQAPTVLVVLRYNMFYVLYPLGVGSELFIIYSALPLAEAKYNILYKYFLIA 179
Y FY FNL P L LRYN F +LYP+G GSE ++ + A+ ++ L K
Sbjct: 118 YAFYAFNLNGDIPAFLTWLRYNTFLILYPIGAGSEFLLVLKSRIAAQYVWS-LNKLLWPI 176
Query: 180 GMLAYIPGFPVLFSHMVAQRRKVMR 204
M Y PG ++++HM+AQRRK+ +
Sbjct: 177 LMSIYPPGLYIMYTHMLAQRRKISK 201
>Hs18104976 [R] KOG3187 Protein tyrosine phosphatase-like protein PTPLA
(contains Pro instead of catalytic Arg)
Length = 288
Score = 122 bits (306), Expect = 4e-28
Identities = 70/207 (33%), Positives = 110/207 (52%), Gaps = 15/207 (7%)
Query: 10 SFLPLYNLLSASAWAYVLYQVVTLYPKIG-QPSFFIATKDLVTYVQCGAIIEVTNSLFGI 68
++L Y++ + W + +V Y + G + + + + + Q A++E+ + L GI
Sbjct: 74 AWLTFYDIAMTAGWLVLAIAMVRFYMEKGTHRGLYKSIQKTLKFFQTFALLEIVHCLIGI 133
Query: 69 VRAPLVTTAAQVASRLLVVIGIFQYVPEAENAHKIYYITLLSAWCIAEIVRYMFYFFNLV 128
V ++ T QV+SR+ +V I + +N + + L AW + EI RY FY F+L+
Sbjct: 134 VPTSVIVTGVQVSSRIFMVWLITHSIKPIQNEESV--VLFLVAWTVTEITRYSFYTFSLL 191
Query: 129 AQAPTVLVVLRYNMFYVLYPLGVGSELFIIYSALPLAEA----------KYNIL--YKYF 176
P + RYN F +LYP+GV EL IY+ALP + KYN+ Y YF
Sbjct: 192 DHLPYFIKWARYNFFIILYPVGVAGELLTIYAALPHVKKTGMFSIRLPNKYNVSFDYYYF 251
Query: 177 LIAGMLAYIPGFPVLFSHMVAQRRKVM 203
L+ M +YIP FP L+ HM+ QRRKV+
Sbjct: 252 LLITMASYIPLFPQLYFHMLRQRRKVL 278
>CE13650 [R] KOG3187 Protein tyrosine phosphatase-like protein PTPLA
(contains Pro instead of catalytic Arg)
Length = 271
Score = 121 bits (304), Expect = 6e-28
Identities = 75/220 (34%), Positives = 121/220 (54%), Gaps = 18/220 (8%)
Query: 7 SIFSFLPLYNLLSASAWAYVLYQVVT-LYPKIGQPSFFIATKDLVTYVQCGAIIEVTNSL 65
S+ ++L YN+L W+ +L + V L + P + + + + Q AI+EV +++
Sbjct: 2 SVQTYLVAYNVLQILGWSAILVKTVLGLANGLTWPQLYESVEFELKIFQTAAILEVIHAI 61
Query: 66 FGIVRAPLVTTAAQVASRLLVVIGIFQYVPEAENAHKIYYITLLSAWCIAEIVRYMFYFF 125
G+VR+P+ TTA QV SR+++V I A I LL AW + E++RY FY
Sbjct: 62 VGLVRSPVGTTAMQVTSRVVLVWPILHLCSTAR--FSIGVPLLLVAWSVTEVIRYSFYAL 119
Query: 126 NLVAQA-PTVLVVLRYNMFYVLYPLGVGSELFIIYSALPLAEAK------------YNIL 172
+++ Q P L+ LRY +FYVLYP+GV EL ++++L + K I
Sbjct: 120 SVLKQPIPYFLLYLRYTLFYVLYPMGVSGELLTLFASLNEVDEKKILTLEMPNRLNMGIS 179
Query: 173 YKYFLIAGMLAYIPGFPVLFSHMVAQRRKVMRSLNGDKRK 212
+ + LI L+YIPGFP L+ +M+ QR+K++ G K+K
Sbjct: 180 FWWVLIIAALSYIPGFPQLYFYMIGQRKKILG--GGSKKK 217
>7297898 [R] KOG3187 Protein tyrosine phosphatase-like protein PTPLA
(contains Pro instead of catalytic Arg)
Length = 245
Score = 121 bits (303), Expect = 8e-28
Identities = 77/210 (36%), Positives = 109/210 (51%), Gaps = 19/210 (9%)
Query: 11 FLPLYNLLSASAWAYVLYQVVTLYPKIG-----QPSFFIATKDLVTYVQCGAIIEVTNSL 65
+L YN W+Y+L+Q+V Y G Q + + T+ V Q A +E+ N+
Sbjct: 25 YLFAYNAGQVVGWSYILWQLVNYYILQGPEFRAQVTLWEYTRLAVIIFQNAAFVEILNAS 84
Query: 66 FGIVRAPLVTTAAQVASRLLVVIGIFQYVPEAENAHKIYYITLLSAWCIAEIVRYMFYFF 125
FG+V++ V T QV SR++VV+G+ P + + + L AW I EI+RY +Y
Sbjct: 85 FGLVKSNPVVTGFQVFSRMMVVVGVVMATPTGKVSPGLPIALL--AWAITEIIRYGYYAL 142
Query: 126 NLVAQAPTVLVVLRYNMFYVLYPLGVGSELFIIYSALPLAEA----------KYNILYKY 175
N+V P +V LRY F VLYP+GV EL + A A K+N + Y
Sbjct: 143 NIVKVVPHFVVFLRYTTFIVLYPIGVTGELLCFWWAQSYARENSVWSVVMPNKWNATFSY 202
Query: 176 --FLIAGMLAYIPGFPVLFSHMVAQRRKVM 203
FL ML YIP FP L+ HM AQRRK++
Sbjct: 203 FGFLWIVMLGYIPIFPQLYLHMFAQRRKIL 232
>Hs20549562 [R] KOG3187 Protein tyrosine phosphatase-like protein PTPLA
(contains Pro instead of catalytic Arg)
Length = 362
Score = 84.0 bits (206), Expect = 1e-16
Identities = 50/206 (24%), Positives = 97/206 (46%), Gaps = 17/206 (8%)
Query: 11 FLPLYNLLSASAWAYVLYQVVTLYPKIGQPSF---FIATKDLVTYVQCGAIIEVTNSLFG 67
+L +YNL+ ++++ + + +G+ SF F D++ + Q A++E N+ G
Sbjct: 149 YLFMYNLVQFLGFSWIFVNLTVRFCILGKESFYDTFHTVADMMYFCQMLAVVETINAAIG 208
Query: 68 IVRAPLVTTAAQVASRLLVVIGIFQYVPEAENAHKIYYITLLSAWCIAEIVRYMFYFFNL 127
+ +P++ + Q+ R ++ IF + E +N ++++ L W EI RY FY
Sbjct: 209 VTTSPVLPSLIQLLGRNFILFIIFGTMEEMQNKAVVFFVFYL--WSAIEIFRYSFYMLTC 266
Query: 128 VAQAPTVLVVLRYNMFYVLYPLGVGSELFIIYSALPLAE------------AKYNILYKY 175
+ VL LRY ++ LYPLG +E + ++P+ K + + +
Sbjct: 267 IDMDWKVLTWLRYTLWIPLYPLGCLAEAVSVIQSIPIFNETGRFSFTLPYPVKIKVRFSF 326
Query: 176 FLIAGMLAYIPGFPVLFSHMVAQRRK 201
FL ++ G + F H+ QRR+
Sbjct: 327 FLQIYLIMIFLGLYINFRHLYKQRRR 352
>Hs7705459 [R] KOG3187 Protein tyrosine phosphatase-like protein PTPLA
(contains Pro instead of catalytic Arg)
Length = 373
Score = 83.2 bits (204), Expect = 2e-16
Identities = 54/217 (24%), Positives = 100/217 (45%), Gaps = 21/217 (9%)
Query: 11 FLPLYNLLSASAWAYVLYQVVTLYPKIGQPSF---FIATKDLVTYVQCGAIIEVTNSLFG 67
+L +YNL+ ++++ + + +G+ SF F D++ + Q A++E N+ G
Sbjct: 149 YLFMYNLVQFLGFSWIFVNLTVRFCILGKESFYDTFHTVADMMYFCQMLAVVETINAAIG 208
Query: 68 IVRAPLVTTAAQVASRLLVVIGIFQYVPEAENAHKIYYITLLSAWCIAEIVRYMFYFFNL 127
+ +P++ + Q+ R ++ IF + E +N ++++ L W EI RY FY
Sbjct: 209 VTTSPVLPSLIQLLGRNFILFIIFGTMEEMQNKAVVFFVFYL--WSAIEIFRYSFYMLTC 266
Query: 128 VAQAPTVLVVLRYNMFYVLYPLGVGSELFIIYSALPLAE------------AKYNILYKY 175
+ VL LRY ++ LYPLG E + ++P+ K + + +
Sbjct: 267 IDMDWKVLTWLRYTLWIPLYPLGCLVEAVSVIQSIPIFNETGRFSFTLPYPVKIKVRFSF 326
Query: 176 FLIAGMLAYIPGFPVLFSHMVAQRRKVMRSLNGDKRK 212
FL ++ G + F H+ QRR+ G KRK
Sbjct: 327 FLQIYLIMIFLGLYINFRHLYKQRRR----RYGKKRK 359
>7298067 [R] KOG3187 Protein tyrosine phosphatase-like protein PTPLA
(contains Pro instead of catalytic Arg)
Length = 371
Score = 70.9 bits (172), Expect = 1e-12
Identities = 52/207 (25%), Positives = 92/207 (44%), Gaps = 18/207 (8%)
Query: 11 FLPLYNLLSASAWAYVLYQVVTLYPKIGQPSF---FIATKDLVTYVQCGAIIEVTNSLFG 67
++ YNL + Y++ + LY + G S + + ++Q +EV + +FG
Sbjct: 151 YMIFYNLAMFVGYLYIMVVMGVLYYRDGVDSIGKTYANVGNAFKFIQLLQYLEVMHPMFG 210
Query: 68 IVRAPLVTTAAQVASRLLVVIGIFQYVPEAENAHKIYYITLLSAWCIAEIVRYMFYFFNL 127
+ V QV+ R ++ + P ++Y+ ++ W + E+VRY +Y L
Sbjct: 211 YTKGSPVVPFFQVSGRNFILFLMIDMEPRMYAKPVVFYVFII--WSLVELVRYPYYLAQL 268
Query: 128 VAQAPTVLVVLRYNMFYVLYPLGVGSELFIIYSALPLAEA----------KYNILYKYFL 177
+ + +L LRY ++ LYP+G+ E I+ +P E +NI + L
Sbjct: 269 LGREVGLLTWLRYTIWIPLYPMGILCEGIIVLRNIPYIEETKRFTVEMPNPWNITFDMVL 328
Query: 178 ---IAGMLAYIPGFPVLFSHMVAQRRK 201
I ML IPG ++ SHM R K
Sbjct: 329 FLKIYLMLLIIPGSYLVMSHMAKLRSK 355
>ECU05g1430 [R] KOG3187 Protein tyrosine phosphatase-like protein PTPLA
(contains Pro instead of catalytic Arg)
Length = 192
Score = 63.5 bits (153), Expect = 2e-10
Identities = 43/128 (33%), Positives = 67/128 (51%), Gaps = 19/128 (14%)
Query: 76 TAAQVASRLLVVIGIFQYVPEAENAHKIYYITLLSAWCIAEIVRYMFYFFNLVAQAPTVL 135
T Q+ SR+ ++ +F Y + + + W ++++VRY FY F +A TV
Sbjct: 66 TVMQLISRMFIMWVVFWYCGIINWTFPV----ITTCWYLSDLVRYAFYTF----RANTVR 117
Query: 136 VVLRYNMFYVLYPLGVGSELFIIYSALPLAEAKYNIL---YKYFLIAGMLAYIPGFPVLF 192
VV RYN+F + P+G E++ + A YN L + Y ++ L YIPGF LF
Sbjct: 118 VV-RYNLFLLTSPIGFVLEMYCL-------RALYNSLGKIFSYLVVLVALLYIPGFIFLF 169
Query: 193 SHMVAQRR 200
SHM+ QR+
Sbjct: 170 SHMLRQRK 177
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.329 0.142 0.418
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 10,807,757
Number of Sequences: 60738
Number of extensions: 410326
Number of successful extensions: 1149
Number of sequences better than 1.0e-05: 10
Number of HSP's better than 0.0 without gapping: 5
Number of HSP's successfully gapped in prelim test: 5
Number of HSP's that attempted gapping in prelim test: 1121
Number of HSP's gapped (non-prelim): 10
length of query: 214
length of database: 30,389,216
effective HSP length: 102
effective length of query: 112
effective length of database: 24,193,940
effective search space: 2709721280
effective search space used: 2709721280
T: 11
A: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.8 bits)