ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactVI3836 good R KOG3780 General function prediction only Thioredoxin binding protein TBP-2/VDUP1
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactVI3836 1341213 1338529 -895
(895 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YJL084c [R] KOG3780 Thioredoxin binding protein TBP-2/VDUP1 575 e-163
YKR021w [R] KOG3780 Thioredoxin binding protein TBP-2/VDUP1 545 e-155
SPBC2D10.04 [R] KOG3780 Thioredoxin binding protein TBP-2/VDUP1 197 5e-50
SPBC839.02 [R] KOG3780 Thioredoxin binding protein TBP-2/VDUP1 150 8e-36
YFR022w [R] KOG3780 Thioredoxin binding protein TBP-2/VDUP1 53 2e-06
YBL101c [R] KOG3780 Thioredoxin binding protein TBP-2/VDUP1 51 7e-06
>YJL084c [R] KOG3780 Thioredoxin binding protein TBP-2/VDUP1
Length = 1046
Score = 575 bits (1481), Expect = e-163
Identities = 333/718 (46%), Positives = 436/718 (60%), Gaps = 90/718 (12%)
Query: 8 VMSPVFPSDIHLGIPKDATPLAKSSSFQVYIQLAEPIIFLQGFSPTHWEGRPPAILRGSL 67
+ SP+FP + + IP DATPLA+SSS Q++I LAEP++FLQGF P E P +LRG L
Sbjct: 7 ISSPLFPMEKDIDIPLDATPLAQSSSLQLFIHLAEPVVFLQGFDPQKTE-YPSVVLRGCL 65
Query: 68 ILRVLKSTKLKSINLTFKGTSKTEWPEGIPPKKQEFVELNDVVKHTWPFFQSDLQ----- 122
++R+LK TKLKSI+L+FKG S+TEWPEGIPPK+QEFVE+ D+V HTW + Q
Sbjct: 66 VVRILKPTKLKSISLSFKGYSRTEWPEGIPPKRQEFVEIKDIVDHTWALYPPTEQKSKKK 125
Query: 123 ---SVPNNQSTEPADLL-KGSNASLFRPLHDD---------------------------- 150
S PN + + L K S ASL+R L D+
Sbjct: 126 MDASAPNESNNAANNFLTKESGASLYRTLSDNETITSRKNSISGLSSLNLSPLGAPGNSS 185
Query: 151 ---MDKPMARRH-------SNAQMRSLSPIGNFLRSTSKDIP--NVK-MVSETFCDMLXX 197
D+ +R SN R+LSPI R+TS + N K + F D+L
Sbjct: 186 VNVKDRESRQRSRSSSVTSSNGPSRNLSPINLLKRATSPSVSHHNYKPTTTSIFSDLLNN 245
Query: 198 XXXXXXXXXXXXXXXXXXA----------TPGP----FIFHPGDYIFSFEHAIPLSYPET 243
+ T G F+F PGDYI++FE IP +YPE+
Sbjct: 246 TFTHNDAASHHGHHIPTSSNHLAMTSNNFTSGSGGEFFVFQPGDYIYAFEELIPQAYPES 305
Query: 244 ITATFGQVEYFLLVNIERQGAFKSGVNAKLPITIVRTPSDNSVEETEPIAISRDWNTHLH 303
I A FG VEYFL +IER GAFKS ++A+ + IVRT + NSVEE+EPI ISRDW L+
Sbjct: 306 IKADFGFVEYFLFASIERPGAFKSNISARQVVNIVRTQAHNSVEESEPIIISRDWENQLY 365
Query: 304 YDIMIVSKDIVLDAFLPIAFRIMPMDKVALHRIRIFLTETLEYYCKGKKVHRLEPTKKFL 363
YDI+I SKDI+LDAFLPI F+ P+DKV LHRIRI++TET+EYYC+ KKVHR+EPTKKFL
Sbjct: 366 YDIVIASKDIILDAFLPITFKFAPLDKVTLHRIRIYVTETMEYYCREKKVHRMEPTKKFL 425
Query: 364 LTEHRAPPIKDLPPDAVPTKAKYLGNLLED-EHGDLVTRDFKYQVFFPERLNYQQKIHPD 422
LTE + P + +LP DA +KAK +GNLL+D ++GDLV ++++YQ+F P R N Q++HPD
Sbjct: 426 LTEQKGPKLPNLPNDANLSKAKNMGNLLQDPKNGDLVNKEYEYQIFIPSRFNNHQQLHPD 485
Query: 423 TSYGTIKSNHWIKISLRLSKNVDGVKKHFEISIDSPIHVLNKLSSHANTLLPSYDTH-AA 481
TSY IK+NHWIKI LRLS+ VD +KH+EISIDSPIHVL++L SHANTLLPSYD H A+
Sbjct: 486 TSYENIKANHWIKICLRLSRVVDNKRKHYEISIDSPIHVLHRLCSHANTLLPSYDGHPAS 545
Query: 482 IPH------SGSVPFGDSDFNMYHDSNLYFPKQVINSPVMSPEVQPLDEKIGLSPVSLSP 535
P S + D + N+YH+SN++FPK+V++SPV+SP VQPLD I P
Sbjct: 546 FPKETDSSISSILESSDDNINLYHNSNIFFPKEVLSSPVLSPNVQPLDILIPHLP----- 600
Query: 536 VAHNRTSLSLLQHRNLSHSELSISELNLRNKVLQSPELSSNIYQPEHIHAELASPQALPL 595
TSL+ + +S+ S+ N + S +L SNIYQPE + ELASPQA+PL
Sbjct: 601 ----STSLTRNSRQFNRNSKSHPSD----NTIFNSAKLKSNIYQPESLQRELASPQAIPL 652
Query: 596 SPISSPTWKPISLAQNQTIDAVSLDDEL--PPFQEALKAES--LPVDPPTYSESVATD 649
SPI+SP + + + D E +ES LP DPP+Y ++V D
Sbjct: 653 SPITSPMSNMEVPPPDFDFSSDFISDAASGTTTTEVSSSESSILPRDPPSYKDTVLHD 710
>YKR021w [R] KOG3780 Thioredoxin binding protein TBP-2/VDUP1
Length = 915
Score = 545 bits (1405), Expect = e-155
Identities = 359/938 (38%), Positives = 502/938 (53%), Gaps = 120/938 (12%)
Query: 9 MSPVFPSDIHLGIPKDATPLAKSSSFQVYIQLAEPIIFLQGFSPTHWEGRPPAILRGSLI 68
++PVFP + + DA PL ++++ QV+++LAEPI+FL+GF P+ILRGSLI
Sbjct: 11 VAPVFPMEQDINAAPDAVPLVQTTTLQVFVKLAEPIVFLKGFETNGLSEIAPSILRGSLI 70
Query: 69 LRVLKSTKLKSINLTFKGTSKTEWPEGIPPKKQEFVELNDVVKHTWPFFQSD-------- 120
+RVLK KLKSI++TFKG S+TEWPEGIPPK++EF ++ VV HTWPF+Q+D
Sbjct: 71 VRVLKPNKLKSISITFKGISRTEWPEGIPPKREEFSDVETVVNHTWPFYQADDGMNSFTL 130
Query: 121 LQSVPNNQSTEPAD-----LLKGSNASLFRP---------------------LHDD--MD 152
NN S P+ LL+ S AS++ P L D +
Sbjct: 131 EHHSSNNSSNRPSMSDEDYLLEKSGASVYIPPTAEPPKDNSNLSLDAYERNSLSSDNLSN 190
Query: 153 KPMARRHSNAQMRSLSPIGNFLRSTSK------DIPNVKMVSETFCDMLXXXXXXXXXXX 206
KP++ S+ + L+ L S+S+ + + TF L
Sbjct: 191 KPVSSDVSHDDSKLLAIQKTPLPSSSRRGSVPANFHGNSLSPHTFISDLFTKTFSNSGAT 250
Query: 207 XXXXXXXXXATPGP-----FIFHPGDYIFSFEHAIPLSYPETITATFGQVEYFLLVNIER 261
TP FIF PGDYI++FE I SYPE+I A FG VEY L ++IER
Sbjct: 251 PSPEQEDNYLTPSKDSKEVFIFRPGDYIYTFEQPISQSYPESIKANFGSVEYKLSIDIER 310
Query: 262 QGAFKSGVNAKLPITIVRTPSDNSVEETEPIAISRDWNTHLHYDIMIVSKDIVLDAFLPI 321
GAFKS ++ +LPI +VR PSD SVEETE IAIS+DW LHYD++I SK+IVL+AFLPI
Sbjct: 311 FGAFKSTIHTQLPIKVVRLPSDGSVEETEAIAISKDWKDLLHYDVVIFSKEIVLNAFLPI 370
Query: 322 AFRIMPMDKVALHRIRIFLTETLEYYCKG----KKVHRLEPTKKFLLTEHRAPPIKDLPP 377
F P+DKV LHRIRI+LTE++EY C +K RLEPTKKFLL EH P + +P
Sbjct: 371 DFHFAPLDKVTLHRIRIYLTESMEYTCNSNGNHEKARRLEPTKKFLLAEHNGPKLPHIPA 430
Query: 378 DAVPTKAKYLGNLLEDE-HGDLVTRDFKYQVFFPERLNYQQKIHPDTSYGTIKSNHWIKI 436
+ P KAK GN+L DE GDLV +DF+++VF P + ++HPDT+Y IK++HWIKI
Sbjct: 431 GSNPLKAKNRGNILLDEKSGDLVNKDFQFEVFVPSKFTNSIRLHPDTNYDKIKAHHWIKI 490
Query: 437 SLRLSKNVDGVKKHFEISIDSPIHVLNKLSSHANTLLPSYDTHAAI--PHSGSVPFGD-S 493
LRLSK +KHFEISIDSPIH+LN+L SHANTLLPSY++H P D
Sbjct: 491 CLRLSKKYGDNRKHFEISIDSPIHILNQLCSHANTLLPSYESHFQYCDEDGNFAPAADQQ 550
Query: 494 DFNMYHDSNLYFPKQVINSPVMSPEVQPLDEKIGLSPVSLSPVAHNRTSLSLLQHRNLSH 553
++ +HDSN++FPK+V++SPV+SP VQ ++ +I P L PV NR + S
Sbjct: 551 NYASHHDSNIFFPKEVLSSPVLSPNVQKMNIRI---PSDL-PVVRNRA-----ESVKKSK 601
Query: 554 SELSISELNLRNKVLQSPELSSNIYQPEHIHAELASPQALPLSPISSPTWKPISLAQNQT 613
S+ + + + + V S +L +NIY+P I EL SPQALPLSPI+SP L+ +
Sbjct: 602 SDNTSKKNDQSSNVFASKQLVANIYKPNQIPRELTSPQALPLSPITSPILNYQPLSNSPP 661
Query: 614 IDAVSLDDELPPFQEALKAESLPVDPPTYSESVATDGXXXXXXXXXXXXXXXXPEICL-- 671
D D +L + A + ++PVDPP+Y + + DG PE+ L
Sbjct: 662 PD---FDFDLAK-RGAADSHAIPVDPPSYFDVLKADG---IELPYYDTSSSKIPELKLNK 714
Query: 672 ----------------SNTTDLVDE-----DIAAGFHFNGNDSGSLNLPTAMMRSHSHND 710
S DL DE DIA+GF+F + S P+ + SH+
Sbjct: 715 SRETLASIEEDSFNGWSQIDDLSDEDDNDGDIASGFNFKLSTSA----PSENVNSHT-PI 769
Query: 711 RTAVXXXXXXXXXXXXXIIVPDSLPSTIKNSSESFNDLEHVLSAAGNDERNGPNESNGAG 770
++ + LPSTI+ +++ FND+ +L
Sbjct: 770 LQSLNMSLDGRKKNRASLHATSVLPSTIRQNNQHFNDINQML------------------ 811
Query: 771 EGNEQDDVFSHS-SADTIQKLEPSQSHTNSISTQPLLLRQVTTEDDQESKASMDLTAMIG 829
G+ +D F S S + +KL + + N I + +V +D +S+D+TA
Sbjct: 812 -GSSDEDAFPKSQSLNFNKKLPILKINDNVIQSNSNSNNRVDNPEDTVD-SSVDITAFYD 869
Query: 830 KERTSWHPLQSEPAMSPLLSQSYSMNVLQSNHALEDFK 867
+S E + + + +YS+NV N L+DFK
Sbjct: 870 PRMSSDSKFDWEVSKNHVDPAAYSVNVASENRVLDDFK 907
>SPBC2D10.04 [R] KOG3780 Thioredoxin binding protein TBP-2/VDUP1
Length = 658
Score = 197 bits (502), Expect = 5e-50
Identities = 138/471 (29%), Positives = 219/471 (46%), Gaps = 87/471 (18%)
Query: 15 SDIHLGIPKDATPLAKSSSFQVYIQLAEPIIFLQGFSPTHWEGRPPAILRGSLILRVLKS 74
SD+ + K A + + I L EP+++L GF + PA+LRG+L+LRV K
Sbjct: 128 SDVVPPVIKKALASSHGGGMSLSIVLLEPVLYLAGFDLNECQIENPALLRGALVLRVAKP 187
Query: 75 TKLKSINLTFKGTSKTEWPEGIPPKKQEFVELNDVVKHTWPFFQSDLQSVP-NNQSTEPA 133
++ I+L+F G S+TE WP + +P T
Sbjct: 188 ANIRGISLSFTGRSRTE----------------------WP------EGIPVKGHDTYED 219
Query: 134 DLLKGSNASLFRPLHDDMDKPMARRHSNAQMRSLSPIGNFLRSTSKDIPNVKMVSETFCD 193
++ N + P D D P +H + R + +P
Sbjct: 220 KVIISHNWKFYEPTMKDADAP---QHG----------ADVARLVGEQLP----------- 255
Query: 194 MLXXXXXXXXXXXXXXXXXXXXATPGPFIFHPGDYIFSFEHAIPLSYPETITATFGQVEY 253
+ G +F PG+Y ++F+ AIP +PE++ A G V Y
Sbjct: 256 ---------------LPSSAAASLRGYSVFAPGEYTYNFDLAIPNCFPESVEAKMGWVRY 300
Query: 254 FLLVNIERQGAFKSGVNAKLPITIVRTPSDNSVEETEPIAISRDWNTHLHYDIMIVSKDI 313
FL +ER G FKS +N + P+ +VRTPS S+ +E I ISRDW+ LHY++ + K
Sbjct: 301 FLEATVERFGTFKSNLNGRTPVQLVRTPSPASLSSSELINISRDWDERLHYELQVSGKSF 360
Query: 314 VLDAFLPIAFRIMPMDKVALHRIRIFLTETLEYYCKGKKVHRLEPTKKFLLTEHRAPPIK 373
L +PI FR + +DKV L+++ I + E+ EY+C+ +K HR++P ++ LL E A
Sbjct: 361 RLGEVVPITFRFLLLDKVRLYKLSISVVESSEYWCRSRKFHRVDPKRRVLLAERSA---- 416
Query: 374 DLPPDAVPTKAKYLGNLLE--DEHGDLVTRDFKYQVFFPERL-NYQQKIHPDTSYGTIKS 430
K + NL E DE L + F + V P L + ++ DT+Y IK
Sbjct: 417 ---------KHQNTDNLFETPDEGDGLSSAVFNFNVALPTCLVKERDRLTFDTTYKYIKV 467
Query: 431 NHWIKISLRLS-KNVDG--VKKHFEISIDSPIHVLNKLSSHANTLLPSYDT 478
H +K L LS +N + +K+FEI+I++P+ +L+ +TLLP Y++
Sbjct: 468 RHRLKALLVLSIENTENPEKRKYFEINIETPVRILSCRCVKDSTLLPPYES 518
>SPBC839.02 [R] KOG3780 Thioredoxin binding protein TBP-2/VDUP1
Length = 530
Score = 150 bits (379), Expect = 8e-36
Identities = 83/258 (32%), Positives = 134/258 (51%), Gaps = 17/258 (6%)
Query: 223 FHPGDYIFSFEHAIPLSYPETITATFGQVEYFLLVNIERQGAFKSGVNAKLPITIVRTPS 282
F+PG+Y+++FE I +YPE+I G+V YFL ++R F ++PI ++R+P
Sbjct: 188 FYPGEYVYNFELPISCTYPESIQTDMGRVYYFLETLVDRSSTFSGKSTGRIPIELIRSPC 247
Query: 283 DNSVEETEPIAISRDWNTHLHYDIMIVSKDIVLDAFLPIAFRIMPMDKVALHRIRIFLTE 342
SV +EPI +S+ W LHY++ + K +V+ +P+ F+ + +V H++R+FL E
Sbjct: 248 STSVATSEPILVSKSWEDRLHYEVQVGEKCVVMGQVVPVNFKFTLLGEVKFHKLRLFLME 307
Query: 343 TLEYYCKGKKVHRLEPTKKFLLTEHRAPPIKDLPPDAVPTKAKYLGNLLEDEHGDLVTRD 402
YYC+ + V R E T++ LL E AP + L D + L D+ D
Sbjct: 308 RRYYYCRQRSVRRKEKTRQLLLYERSAPKNQCLLSDWKQVRPDVYE--LSDQVRIPGCHD 365
Query: 403 FKYQVFFPERLNYQQKIHPDTSYGTIKSNHWIKISLRL----SKNVDGVKKHFEISIDSP 458
+ +H DT+Y IK H ++ LR S + G K+ EI IDSP
Sbjct: 366 MAANI-----------VHFDTTYPNIKITHTVRTVLRFSCENSPELMGSAKYLEIYIDSP 414
Query: 459 IHVLNKLSSHANTLLPSY 476
+ +L+ S +T+LP+Y
Sbjct: 415 VRLLSCRCSDGSTMLPAY 432
Score = 94.7 bits (234), Expect = 5e-19
Identities = 46/100 (46%), Positives = 66/100 (66%), Gaps = 1/100 (1%)
Query: 28 LAKSSSFQVYIQLAEPIIFLQGFSPTHWEGRPPAILRGSLILRVLKSTKLKSINLTFKGT 87
L+ +S+ +V I LAEP+++L G + + + A+LRGSL +++ K KLK I L+FKG
Sbjct: 64 LSSNSNARVAIALAEPVLYLPGATSSEIQSEHSAVLRGSLCIQIYKPVKLKKIQLSFKGK 123
Query: 88 SKTEWPEGIPPKKQEFVELNDVVKHTWPFFQSDLQSVPNN 127
S+TEWPEGIPPK + E N ++ H W FF S+ Q V N
Sbjct: 124 SRTEWPEGIPPKLFDTYEENSIMNHCWVFFHSE-QKVDEN 162
>YFR022w [R] KOG3780 Thioredoxin binding protein TBP-2/VDUP1
Length = 733
Score = 52.8 bits (125), Expect = 2e-06
Identities = 31/132 (23%), Positives = 63/132 (47%), Gaps = 1/132 (0%)
Query: 216 ATPGPFIFHPGDYIFSFEHAIPLSYPETITATFGQVEYFLLVNIERQGAFKSGVNAKLPI 275
++P G+Y F F +P S PE++ + + + ++ + S + + I
Sbjct: 150 SSPSSCTLDKGNYDFPFSAILPGSLPESVESLPNCFVTYSMESVIERSKNYSDLICRKNI 209
Query: 276 TIVRTPSDNSVEETEPIAISRDWNTHLHYDIMIVSKDIVLDAFLPIAFRIMPMDK-VALH 334
++RT S +VE +E + + W + Y I + +K + + + PI I+P+ K + L
Sbjct: 210 RVLRTISPAAVELSETVCVDNSWPDKVDYSISVPNKAVAIGSATPINISIVPLSKGLKLG 269
Query: 335 RIRIFLTETLEY 346
I++ L E +Y
Sbjct: 270 SIKVVLFENYQY 281
>YBL101c [R] KOG3780 Thioredoxin binding protein TBP-2/VDUP1
Length = 1117
Score = 51.2 bits (121), Expect = 7e-06
Identities = 28/94 (29%), Positives = 53/94 (55%), Gaps = 2/94 (2%)
Query: 259 IERQGAFKSGVNAKLPITIVRTPSDNSVEET-EPIAISRDWNTHLHYDIMIVSKDIVLDA 317
++ + + + + A+ PI ++RTP +V +PI I+R W L Y+I K + L++
Sbjct: 545 LKNEESGEEDIFAEYPIKVIRTPPPVAVSTANKPIYINRVWTDSLSYEISFAQKYVSLNS 604
Query: 318 FLPIAFRIMPMDK-VALHRIRIFLTETLEYYCKG 350
+PI ++ P+ K V + RI + +TE + + KG
Sbjct: 605 EVPIKIKLAPICKNVCVKRIHVSITERVTFVSKG 638
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.314 0.132 0.383
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 54,102,188
Number of Sequences: 60738
Number of extensions: 2377852
Number of successful extensions: 5388
Number of sequences better than 1.0e-05: 6
Number of HSP's better than 0.0 without gapping: 4
Number of HSP's successfully gapped in prelim test: 2
Number of HSP's that attempted gapping in prelim test: 5359
Number of HSP's gapped (non-prelim): 17
length of query: 895
length of database: 30,389,216
effective HSP length: 115
effective length of query: 780
effective length of database: 23,404,346
effective search space: 18255389880
effective search space used: 18255389880
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)