ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactVI3920 good D KOG1213 Cell cycle control, cell division, chromosome partitioning Sister chromatid cohesion complex Cohesin, subunit RAD21/SCC1
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactVI3920 1368194 1369993 600
(600 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YDL003w [D] KOG1213 Sister chromatid cohesion complex Cohesin su... 277 3e-74
SPCC338.17c [D] KOG1213 Sister chromatid cohesion complex Cohesi... 70 9e-12
Hs5453994 [D] KOG1213 Sister chromatid cohesion complex Cohesin ... 60 9e-09
7289833 [D] KOG1213 Sister chromatid cohesion complex Cohesin su... 59 2e-08
At5g16270 [D] KOG1213 Sister chromatid cohesion complex Cohesin ... 56 1e-07
CE04726 [D] KOG1213 Sister chromatid cohesion complex Cohesin su... 55 3e-07
Hs18592523 [D] KOG1213 Sister chromatid cohesion complex Cohesin... 54 9e-07
CE02628 [D] KOG1213 Sister chromatid cohesion complex Cohesin su... 53 1e-06
Hs9845293 [D] KOG1213 Sister chromatid cohesion complex Cohesin ... 50 1e-05
>YDL003w [D] KOG1213 Sister chromatid cohesion complex Cohesin subunit
RAD21/SCC1
Length = 566
Score = 277 bits (709), Expect = 3e-74
Identities = 207/607 (34%), Positives = 302/607 (49%), Gaps = 55/607 (9%)
Query: 4 NSNSHTQVRLNTSNGPLAQIWLASNLSSINR-NIAKTNIVESVEEIAKAAGVNLDDESVE 62
N T +RL T+ GPLAQIWLASN+S+I R ++ +T+I ES +EIAKA+G + + E
Sbjct: 5 NPQRLTVLRLATNKGPLAQIWLASNMSNIPRGSVIQTHIAESAKEIAKASGCDDESGDNE 64
Query: 63 PITLRASGELLHGVVKVYSQKASYLLTDITDLLSKVKSIFKGSLNKSVTI-QLDTVAKLD 121
ITLR SGELL G+V+VYS++A++LLTDI D L+K+ +FK S + T+ +L+TV ++
Sbjct: 65 YITLRTSGELLQGIVRVYSKQATFLLTDIKDTLTKISMLFKTSQKMTSTVNRLNTVTRVH 124
Query: 122 QLLLQDAVTELDVLEMPSLDFLKDIQVPEGFLIAERSMERQVQGAAPVTSAIAAQQQAWD 181
QL+L+DAVTE +VL P L+FL D +P G + E SMER+VQGAAP WD
Sbjct: 125 QLMLEDAVTEREVLVTPGLEFLDDTTIPVGLMAQENSMERKVQGAAP-----------WD 173
Query: 182 MSLEVGRRFLADEDDDLNAIEHHDSSHLKLDFDLGDSNQSNNTKSWGEGTRVTASEVNAD 241
SLEVGRRF DED EH++ S + LDFD+ + +KSW EGTR S N D
Sbjct: 174 TSLEVGRRFSPDED-----FEHNNLSSMNLDFDIEEG--PITSKSWEEGTR--QSSRNFD 224
Query: 242 DGENEGXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXISGNQSSHGSDMSVEIGRRADIT 301
EN +Q++ D SVE GRR +
Sbjct: 225 THEN-----------YIQDDDFPLDDAGTIGWDLGITEKNDQNNDDDDNSVEQGRRLGES 273
Query: 302 HSLHDDTLLDFDLGLPKDTEPEHQEQ-AEAYIPPRAVKKRAPRNKAFINVKKVLIDADAE 360
+ T FDL + K+ + + +A + + RN +N K + ID + E
Sbjct: 274 IMSEEPTDFGFDLDIEKEAPAGNIDTITDAMTESQPKQTGTRRNSKLLNTKSIQIDEETE 333
Query: 361 LNDS-----EVKGGPSDSILIVSDETSSAISKKKRAIDELYSDLDFLPQKIISNFFNHKA 415
++S K S+++L + KR E+ + +LP I+ NF ++++
Sbjct: 334 NSESIASSNTYKEERSNNLLTPQPTNFTT----KRLWSEITESMSYLPDPILKNFLSYES 389
Query: 416 SKKPRAXXXXXXXXXXXXXXXXXXXXXXXXVHNSDPFDHQQMGFDAESEGPVFADDEPPV 475
KK R + N+ D+ F+ D+
Sbjct: 390 LKK-RKIHNGREGSIEEPELNVSLNLTDDVISNAGTNDN---SFNE------LTDNMSDF 439
Query: 476 LAADTSMEENDYQAIQSDEFASRGSIEKEKSQKVELATGEIVSKSTVEMATLLRDEMS-S 534
+ D + E + + +R +++KV GE+ SK+ V+MA +LR E+S
Sbjct: 440 VPIDAGLNEAPFPEENIIDAKTRNEQTTIQTEKVRPTPGEVASKAIVQMAKILRKELSEE 499
Query: 535 GEATFDKILTSKYQ-DNAVITKRMASKAFFELLSLATADCISLKQKETFGQITILGKSNL 593
E F +L S+ + ITKR AS+ FF++LSLAT CI L Q E FG I I K L
Sbjct: 500 KEVIFTDVLKSQANTEPENITKREASRGFFDILSLATEGCIGLSQTEAFGNIKIDAKPAL 559
Query: 594 YETFVTA 600
+E F+ A
Sbjct: 560 FERFINA 566
>SPCC338.17c [D] KOG1213 Sister chromatid cohesion complex Cohesin subunit
RAD21/SCC1
Length = 628
Score = 70.1 bits (170), Expect = 9e-12
Identities = 63/239 (26%), Positives = 106/239 (43%), Gaps = 27/239 (11%)
Query: 15 TSNGPLAQIWLASN----LSSINRNIAKTNIVESVEEIAKAAGVNLDDESVEPITLRASG 70
+ GPLA++WLA++ LS + T+I +SV I E P+ LR SG
Sbjct: 9 SKKGPLAKVWLAAHWEKKLSKVQT--LHTSIEQSVHAIVT--------EETAPMALRLSG 58
Query: 71 ELLHGVVKVYSQKASYLLTDITDLLSKVKSIFK----GSLNKSVTIQ----LDTVAKLDQ 122
+L+ GVV++YS+KA YLL D T+ L ++K F+ + + +Q D V +
Sbjct: 59 QLMLGVVRIYSRKARYLLEDCTEALMRLKMSFQPGQVDMIEPATALQSLKGKDAVTQSAN 118
Query: 123 LLLQDAVTELDVLEMPSLDFLKDIQVPEGFLIAERSMERQVQGAAPVTSAIAAQQQAWDM 182
L L + +TE D+L +P F D Q + RS + P++S+ + +
Sbjct: 119 LTLPETITEFDLL-VPDSTF--DFQWSQLLRTPSRSSNTLELHSLPISSSPSFPSS--QL 173
Query: 183 SLEVGRRFLADEDDDLNAIEHHDSSHLKLDFDLGDSNQSNNTKSWGEGTRVTASEVNAD 241
S+E GR + L H + ++ + +S + + + EV D
Sbjct: 174 SIEAGRNAQVESGFSLGESFAHVGNDMQFHLPISNSGAATPRSVHSDNQSQISIEVGRD 232
>Hs5453994 [D] KOG1213 Sister chromatid cohesion complex Cohesin subunit
RAD21/SCC1
Length = 631
Score = 60.1 bits (144), Expect = 9e-09
Identities = 57/210 (27%), Positives = 94/210 (44%), Gaps = 22/210 (10%)
Query: 15 TSNGPLAQIWLASNLSS--INRNIAKTNIVESVEEIAKAAGVNLDDESVEPITLRASGEL 72
+ GPLA+IWLA++ ++ + N+ SVE I + LR SG L
Sbjct: 9 SKRGPLAKIWLAAHWDKKLTKAHVFECNLESSVESIISPK---------VKMALRTSGHL 59
Query: 73 LHGVVKVYSQKASYLLTDITDLLSKVKSIFKGSLNKSVTIQLDTVAKLDQLLLQDAVTEL 132
L GVV++Y +KA YLL D + K+K F+ + + + A + + L + +
Sbjct: 60 LLGVVRIYHRKAKYLLADCNEAFIKIKMAFRPGVVD--LPEENREAAYNAITLPEEFHDF 117
Query: 133 DVLEMPSLDFLKDIQVPEGFLIAERSMERQVQGAAPVTSAIAAQQQAWDMSL---EVGRR 189
D +P LD DI V + F + + +E +I + D + E+ R
Sbjct: 118 D-QPLPDLD---DIDVAQQFSLNQSRVEEITMREEVGNISILQENDFGDFGMDDREIMRE 173
Query: 190 FLADEDDDLNAIEHHDSSHLKLDFDLGDSN 219
A EDDD+ + +S+L L+ + SN
Sbjct: 174 GSAFEDDDM--LVSTTTSNLLLESEQSTSN 201
>7289833 [D] KOG1213 Sister chromatid cohesion complex Cohesin subunit
RAD21/SCC1
Length = 677
Score = 58.9 bits (141), Expect = 2e-08
Identities = 35/88 (39%), Positives = 50/88 (56%), Gaps = 11/88 (12%)
Query: 18 GPLAQIWLASNLSS--INRNIAKTNIVESVEEIAKAAGVNLDDESVEPITLRASGELLHG 75
GPLA+IWLA++ ++ +TNI +SVE I + + LR SG LL G
Sbjct: 12 GPLARIWLAAHWDKKITKAHVFETNIEKSVEGILQPK---------VKLALRTSGHLLLG 62
Query: 76 VVKVYSQKASYLLTDITDLLSKVKSIFK 103
VV++YS+KA YLL D + K+K F+
Sbjct: 63 VVRIYSRKAKYLLADCNEAFVKIKMAFR 90
>At5g16270 [D] KOG1213 Sister chromatid cohesion complex Cohesin subunit
RAD21/SCC1
Length = 1021
Score = 56.2 bits (134), Expect = 1e-07
Identities = 48/168 (28%), Positives = 78/168 (45%), Gaps = 24/168 (14%)
Query: 18 GPLAQIWLASNLSSINRNIAKTNIVESVEEIAKAAGVNLDDESVEPITLRASGELLHGVV 77
GPL IW+A++L R + K + ++ GV SV PI LR S LL GVV
Sbjct: 12 GPLGTIWIAAHLE---RKLRKNQVADT------DIGV-----SVAPIALRLSSHLLLGVV 57
Query: 78 KVYSQKASYLLTDITDLLSKVKSIFKGSLNKSVTIQL---DTVAKLDQLLLQDAVTELDV 134
++YS+K +YL D ++ L KVK F +S + L ++ A + L + +LD
Sbjct: 58 RIYSRKVNYLFDDCSEALLKVKQAF-----RSAAVDLPPEESTAPYHSITLPETF-DLDD 111
Query: 135 LEMPSLDFLKDIQVPEGFLIAER-SMERQVQGAAPVTSAIAAQQQAWD 181
E+P + + V E+ +++ + G TS ++ D
Sbjct: 112 FELPDNEIFQGNYVDHHVSTKEQITLQDTMDGVVYSTSQFGLDERFGD 159
>CE04726 [D] KOG1213 Sister chromatid cohesion complex Cohesin subunit
RAD21/SCC1
Length = 652
Score = 55.1 bits (131), Expect = 3e-07
Identities = 31/97 (31%), Positives = 56/97 (56%), Gaps = 12/97 (12%)
Query: 15 TSNGPLAQIWLASNLSS--INRNIAKTNIVESVEEIAKAAGVNLDDESVEPITLRASGEL 72
+ GPL+++WLA++ I +T++ E+V EI + + + + LR +G L
Sbjct: 64 SKKGPLSKVWLAAHWEKKLSKAQIFETDVDEAVNEIMQPS---------QKLALRTTGHL 114
Query: 73 LHGVVKVYSQKASYLLTDITDLLSKVKSIFK-GSLNK 108
L G+ +VYS+K YLL D + K+K +F+ G+L++
Sbjct: 115 LLGICRVYSRKTKYLLADCNEAFLKIKLVFRSGALDQ 151
>Hs18592523 [D] KOG1213 Sister chromatid cohesion complex Cohesin subunit
RAD21/SCC1
Length = 392
Score = 53.5 bits (127), Expect = 9e-07
Identities = 34/93 (36%), Positives = 52/93 (55%), Gaps = 13/93 (13%)
Query: 13 LNTSNGPLAQIWLASNLSSINRNIAKTNIVESVEEIAKAAGVNLDDESVEP---ITLRAS 69
L + GPLA+IWLA++ + + K ++ E EI ++ + P I LR S
Sbjct: 7 LMSKRGPLAKIWLAAHWE---KKLTKAHVFECNLEITI-------EKILSPKVKIALRTS 56
Query: 70 GELLHGVVKVYSQKASYLLTDITDLLSKVKSIF 102
G LL GVV++Y++KA YLL D ++ K+K F
Sbjct: 57 GHLLLGVVRIYNRKAKYLLADCSEAFLKMKMTF 89
>CE02628 [D] KOG1213 Sister chromatid cohesion complex Cohesin subunit
RAD21/SCC1
Length = 645
Score = 53.1 bits (126), Expect = 1e-06
Identities = 30/97 (30%), Positives = 51/97 (51%), Gaps = 11/97 (11%)
Query: 18 GPLAQIWLASNLSS--INRNIAKTNIVESVEEIAKAAGVNLDDESVEPITLRASGELLHG 75
GPLA++WLA++ I +T++ +++EE+ + + LR G LL G
Sbjct: 12 GPLAKVWLAAHWEKKLTKAQIFETDVPQAIEEVIRPK---------VKMALRTVGHLLLG 62
Query: 76 VVKVYSQKASYLLTDITDLLSKVKSIFKGSLNKSVTI 112
+V++YS+K YLL D + K+K F+ + V I
Sbjct: 63 IVRIYSKKTRYLLADTNEAYQKMKINFRNGFSFEVDI 99
>Hs9845293 [D] KOG1213 Sister chromatid cohesion complex Cohesin subunit
RAD21/SCC1
Length = 547
Score = 50.1 bits (118), Expect = 1e-05
Identities = 37/130 (28%), Positives = 60/130 (45%), Gaps = 13/130 (10%)
Query: 13 LNTSNGPLAQIWLASNLSS--INRNIAKTNIVESVEEIAKAAGVNLDDESV----EPITL 66
L G A IWLA+ S + R + N+V++ EEI V + +L
Sbjct: 8 LQRHTGCFATIWLAATRGSRLVKREYLRVNVVKTCEEILNYVLVRVQPPQPGLPRPRFSL 67
Query: 67 RASGELLHGVVKVYSQKASYLLTDITDLLSKVKSIFKGSLNKSVTIQLDTVAKLDQLLLQ 126
S +L GV++VYSQ+ YL DI +L ++ + I++D +L LLL
Sbjct: 68 YLSAQLQIGVIRVYSQQCQYLAEDIQHILERLH-------RAQLQIRIDMETELPSLLLP 120
Query: 127 DAVTELDVLE 136
+ + ++ LE
Sbjct: 121 NHLAMMETLE 130
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.311 0.128 0.345
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 30,378,790
Number of Sequences: 60738
Number of extensions: 1154528
Number of successful extensions: 3050
Number of sequences better than 1.0e-05: 9
Number of HSP's better than 0.0 without gapping: 1
Number of HSP's successfully gapped in prelim test: 8
Number of HSP's that attempted gapping in prelim test: 3028
Number of HSP's gapped (non-prelim): 15
length of query: 600
length of database: 30,389,216
effective HSP length: 112
effective length of query: 488
effective length of database: 23,586,560
effective search space: 11510241280
effective search space used: 11510241280
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)