ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactVI4142 good F KOG3985 Nucleotide transport and metabolism Methylthioadenosine phosphorylase MTAP
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactVI4142 1445904 1444891 -338
(338 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YLR017w [F] KOG3985 Methylthioadenosine phosphorylase MTAP 469 e-132
SPAC16C9.02c [F] KOG3985 Methylthioadenosine phosphorylase MTAP 259 3e-69
Hs4505273 [F] KOG3985 Methylthioadenosine phosphorylase MTAP 150 3e-36
7302794 [F] KOG3985 Methylthioadenosine phosphorylase MTAP 135 8e-32
CE01747 [F] KOG3985 Methylthioadenosine phosphorylase MTAP 117 2e-26
YLR209c [F] KOG3984 Purine nucleoside phosphorylase 52 9e-07
SPAC1805.16c [F] KOG3984 Purine nucleoside phosphorylase 50 5e-06
>YLR017w [F] KOG3985 Methylthioadenosine phosphorylase MTAP
Length = 337
Score = 469 bits (1208), Expect = e-132
Identities = 226/338 (66%), Positives = 270/338 (79%), Gaps = 1/338 (0%)
Query: 1 MKTFVRKFNVIPKFYSFKMTNSTQLPQTFXXXXXXXXXXXXXXXXXXCLEPIAILPCMET 60
M F+V + K+ +++LP F CLEPIA+LP M T
Sbjct: 1 MNRIKNTFSVAKRLKLSKVMTNSELPSIFEGTVDLGIIGGTGLYNLDCLEPIALLPPMVT 60
Query: 61 PWGKTSSPITVSRVKSDETEHFHVAFIARHGVNHEYPPTRVPFRANIAALKNLKTSAILS 120
PWG TSSP+T+S+ + HFHVAFIARHG+NHEYPPT+VPFRAN+AALKNL A+LS
Sbjct: 61 PWGTTSSPVTISQFVGTNS-HFHVAFIARHGINHEYPPTKVPFRANMAALKNLNCKAVLS 119
Query: 121 FSAVGSLQQEIKPRDFVLPQQIIDRTKGIRESSYFNDEGLVGHVVFGEPFSKSFAEYIYQ 180
FSAVGSLQ IKPRDFVLPQQIIDRTKGIR SSYFNDEGLVGHV FG+PFS+ FAEYIYQ
Sbjct: 120 FSAVGSLQPHIKPRDFVLPQQIIDRTKGIRHSSYFNDEGLVGHVGFGQPFSQKFAEYIYQ 179
Query: 181 FKDILENPESEEPCLLHYNRELTVVCMEGPQFSTRAESKMYRLMGGDVINMSVIPEAKLA 240
FK+ + NPESEEPC LHY++++TVVCMEGPQFSTRAESKMYR+ GG VINMSVIPEAKLA
Sbjct: 180 FKNEITNPESEEPCHLHYDKDMTVVCMEGPQFSTRAESKMYRMFGGHVINMSVIPEAKLA 239
Query: 241 RECEILYQMVCMSTDYDAWRDEEEPVSVQTVIRNLQNNAKNANHLASRVILEMAKQLPEF 300
RECE+ YQM+CMSTDYDAWRDE EPV+V+TVI NL NN +NAN LAS++I+ MAK++PEF
Sbjct: 240 RECELPYQMICMSTDYDAWRDEAEPVTVETVIGNLTNNGRNANILASKIIVSMAKEIPEF 299
Query: 301 MNNGDGLKDAMKYSISTKPEAMSQDALAKLKFLFPNHW 338
M+ GDGL+ ++K SISTKPEAMS++ L +L++LFPN+W
Sbjct: 300 MHTGDGLRGSIKKSISTKPEAMSKETLERLRYLFPNYW 337
>SPAC16C9.02c [F] KOG3985 Methylthioadenosine phosphorylase MTAP
Length = 307
Score = 259 bits (663), Expect = 3e-69
Identities = 144/281 (51%), Positives = 186/281 (65%), Gaps = 16/281 (5%)
Query: 60 TPWGKTSSPITVSRVKSDETEHFHVAFIARHGVNHEYPPTRVPFRANIAALKNLKTSAIL 119
TPWG +SPI+++R T F +AF+ARHGV H Y PT VP RANIAALK+L AI+
Sbjct: 34 TPWGYPASPISIART----TSGFLIAFLARHGVGHIYTPTEVPSRANIAALKSLGVLAIV 89
Query: 120 SFSAVGSLQQEIKPRDFVLPQQIIDRTKGIRESSYFNDEGLVGHVVFGEPFSKSFAEYIY 179
SFSAVGSL+++I P DFVLP QIIDRT R +++F + G V HV FG+PF + E +
Sbjct: 90 SFSAVGSLREDIPPEDFVLPTQIIDRTLCARPNTFF-ESGCVAHVSFGDPFDQDLYEILS 148
Query: 180 QFKDILENPESEEPCLLHYNR---ELTVVCMEGPQFSTRAESKMYRLMGGDVINMSVIPE 236
L+N LH R +LTVVCMEGP FSTRAES +YR G +INMSVIPE
Sbjct: 149 SCGSNLKNGSK-----LHTKRKGDDLTVVCMEGPAFSTRAESNLYRSWGASIINMSVIPE 203
Query: 237 AKLARECEILYQMVCMSTDYDAWRDEEEPVSVQTVIRNLQNNAKNANHLASRVILEM-AK 295
AKLARE EI YQMVCM+TDYD WR EEPV+V+TV+ ++ NN NA + ++ A
Sbjct: 204 AKLAREAEIAYQMVCMATDYDCWRMNEEPVTVETVMEHISNNKDNAKIFLLEAVKKLEAP 263
Query: 296 QLPEFMNNGDGLKDAMKYSISTKPEAMSQDALAKLKFLFPN 336
L F+ G L+++++ I T + + DA+ +L+FLFPN
Sbjct: 264 LLQGFL--GRNLRESVQNGIQTNHKHRNPDAIRRLQFLFPN 302
>Hs4505273 [F] KOG3985 Methylthioadenosine phosphorylase MTAP
Length = 283
Score = 150 bits (379), Expect = 3e-36
Identities = 91/261 (34%), Positives = 142/261 (53%), Gaps = 19/261 (7%)
Query: 58 METPWGKTSSPITVSRVKSDETEHFHVAFIARHGVNHEYPPTRVPFRANIAALKNLKTSA 117
++TP+GK S + + ++K+ + +ARHG H P++V ++ANI ALK +
Sbjct: 34 VDTPFGKPSDALILGKIKNVDC-----ILLARHGRQHTIMPSKVNYQANIWALKEEGCTH 88
Query: 118 ILSFSAVGSLQQEIKPRDFVLPQQIIDRTKGIRESSYFNDEGL---VGHVVFGEPFSKSF 174
++ +A GSL++EI+P D V+ Q IDRT +S Y V H+ EPF
Sbjct: 89 VIVTTACGSLREEIQPGDIVIIDQFIDRTTMRPQSFYDGSHSCARGVCHIPMAEPFCPKT 148
Query: 175 AEYIYQFKDILENPESEEPCLLHYNRELTVVCMEGPQFSTRAESKMYRLMGGDVINMSVI 234
E + E+ + L + + T+V +EGP+FS+RAES M+R G DVINM+ +
Sbjct: 149 REVLI---------ETAKKLGLRCHSKGTMVTIEGPRFSSRAESFMFRTWGADVINMTTV 199
Query: 235 PEAKLARECEILYQMVCMSTDYDAWRDEEEPVSVQTVIRNLQNNAKNANHLASRVILEMA 294
PE LA+E I Y + M+TDYD W++ EE VSV V++ L+ NA A L I ++
Sbjct: 200 PEVVLAKEAGICYASIAMATDYDCWKEHEEAVSVDRVLKTLKENANKAKSLLLTTIPQIG 259
Query: 295 KQLPEFMNNGDGLKDAMKYSI 315
E+ LK+ ++S+
Sbjct: 260 S--TEWSETLHNLKNMAQFSV 278
>7302794 [F] KOG3985 Methylthioadenosine phosphorylase MTAP
Length = 289
Score = 135 bits (340), Expect = 8e-32
Identities = 82/239 (34%), Positives = 132/239 (54%), Gaps = 11/239 (4%)
Query: 58 METPWGKTSSPITVSRVKSDETEHFHVAFIARHGVNHEYPPTRVPFRANIAALKNLKTSA 117
+ETP+G+ S + + + +ARHG H+ P+ V +RANI AL+++ +
Sbjct: 40 VETPYGEPSDALIEGEINGVQC-----VLLARHGRKHDIMPSNVNYRANIWALRDVGCTH 94
Query: 118 ILSFSAVGSLQQEIKPRDFVLPQQIIDRTKGIRESSYFNDEGLVGHVVFGEPFSKSFAEY 177
++ +A GSL++EIKP + V+P IDRT R ++++ + V P +F+E
Sbjct: 95 LIVSTACGSLREEIKPGNLVVPHDFIDRTTK-RLQTFYDGKAQSPRGVCHLPMFPAFSE- 152
Query: 178 IYQFKDILENPESEEPCLLHYNRELTVVCMEGPQFSTRAESKMYRLMGGDVINMSVIPEA 237
+ ++IL E H + T+V +EGP+FS+R+ES M+R GGD+INM+ PE
Sbjct: 153 --RTRNILLQAAKELEIPAH--DKATIVTIEGPRFSSRSESHMFRQWGGDLINMTTCPEV 208
Query: 238 KLARECEILYQMVCMSTDYDAWRDEEEPVSVQTVIRNLQNNAKNANHLASRVILEMAKQ 296
LA+E +LY V ++TDYD WR E V+VQ V+R N + + +AK+
Sbjct: 209 VLAKEAGLLYGSVAIATDYDCWRMGCEGVNVQDVLRTFAENVIKVKKILVNAVGRIAKE 267
>CE01747 [F] KOG3985 Methylthioadenosine phosphorylase MTAP
Length = 285
Score = 117 bits (294), Expect = 2e-26
Identities = 74/248 (29%), Positives = 126/248 (49%), Gaps = 19/248 (7%)
Query: 49 LEPIAILPCMETPWGKTSSPITVSRVKSDETEHFHVAFIARHGVNHEYPPTRVPFRANIA 108
L+P+ + ++TP+GK S + + E +ARHG H+ P V FRAN+
Sbjct: 19 LDPVTV--AVDTPYGKPSDDVVEGTINGVEC-----VLLARHGRKHDIMPGNVNFRANLW 71
Query: 109 ALKNLKTSAILSFSAVGSLQQEIKPRDFVLPQQIID-RTKGIRESSYFNDEGLVGHVVFG 167
AL + I++ +A GSLQ+ ++P + P + R + SY G V H+
Sbjct: 72 ALYSRGVDVIIASTACGSLQENVEPGHLLFPDSVTTGRQSTFFDGSYDQAPG-VCHIQAH 130
Query: 168 EPFSKSFAEYIYQFKDILENPESEEPCLLHYNRELTVVCMEGPQFSTRAESKMYRLMGGD 227
+++ + + + E C L ++R VC+EGP+FST+AES +++ G
Sbjct: 131 PTYNEKLRQVLIS---------TAERCQLVHHRTGFGVCIEGPRFSTKAESMVFKSWGAS 181
Query: 228 VINMSVIPEAKLARECEILYQMVCMSTDYDAWRDEEEPVSVQTVIRNLQNNAKNANHLAS 287
++NM+++PE LA+E I Y + TDYD W+ EE+ V+ +V++ N + A L
Sbjct: 182 LVNMTMMPECILAKELGIPYATTALVTDYDCWK-EEDHVTASSVMKVFAANVEKAKTLFV 240
Query: 288 RVILEMAK 295
+ E+ K
Sbjct: 241 EAVGEIGK 248
>YLR209c [F] KOG3984 Purine nucleoside phosphorylase
Length = 311
Score = 52.4 bits (124), Expect = 9e-07
Identities = 23/43 (53%), Positives = 29/43 (66%)
Query: 201 ELTVVCMEGPQFSTRAESKMYRLMGGDVINMSVIPEAKLAREC 243
E T + GP F TRAESKM R++GGD + MS +PE +AR C
Sbjct: 207 EGTYTFVSGPTFETRAESKMIRMLGGDAVGMSTVPEVIVARHC 249
>SPAC1805.16c [F] KOG3984 Purine nucleoside phosphorylase
Length = 315
Score = 50.1 bits (118), Expect = 5e-06
Identities = 28/79 (35%), Positives = 40/79 (50%), Gaps = 1/79 (1%)
Query: 207 MEGPQFSTRAESKMYRLMGGDVINMSVIPEAKLARECEILYQMVCMSTDYDAWRDEEEPV 266
+ GP F TRAES+M LMG D + MS +PE +AR C I + + T+ +
Sbjct: 214 VSGPCFETRAESRMLALMGADCVGMSTVPEVVVARHCGIRVLAISLVTNNVVVEESPSAK 273
Query: 267 SVQTVIRNLQNNAKNANHL 285
+ V N+ + ANHL
Sbjct: 274 DLVEVDSNVMSKGA-ANHL 291
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.320 0.134 0.397
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,275,376
Number of Sequences: 60738
Number of extensions: 778928
Number of successful extensions: 1736
Number of sequences better than 1.0e-05: 7
Number of HSP's better than 0.0 without gapping: 6
Number of HSP's successfully gapped in prelim test: 1
Number of HSP's that attempted gapping in prelim test: 1720
Number of HSP's gapped (non-prelim): 8
length of query: 338
length of database: 30,389,216
effective HSP length: 107
effective length of query: 231
effective length of database: 23,890,250
effective search space: 5518647750
effective search space used: 5518647750
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)