ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactVI4224 good S KOG1426 Function unknown FOG: RCC1 domain
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactVI4224 1473462 1472416 -349
(349 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YAL020c [S] KOG1426 FOG: RCC1 domain 219 5e-57
SPAC10F6.04 [S] KOG1426 FOG: RCC1 domain 129 5e-30
Hs6912330 [S] KOG1426 FOG: RCC1 domain 99 9e-21
At5g63860 [S] KOG1426 FOG: RCC1 domain 84 2e-16
At1g27060 [S] KOG1426 FOG: RCC1 domain 78 2e-14
CE07026 [S] KOG1426 FOG: RCC1 domain 75 1e-13
7296072 [S] KOG1426 FOG: RCC1 domain 65 1e-10
Hs4506581_1 [S] KOG1426 FOG: RCC1 domain 64 3e-10
7297063 [S] KOG1427 Uncharacterized conserved protein contains R... 64 4e-10
Hs7657152 [O] KOG0941 E3 ubiquitin protein ligase 62 1e-09
Hs7705931 [O] KOG0941 E3 ubiquitin protein ligase 61 3e-09
7292061 [O] KOG0941 E3 ubiquitin protein ligase 60 6e-09
Hs4758520 [S] KOG1426 FOG: RCC1 domain 58 2e-08
Hs4557445 [S] KOG1426 FOG: RCC1 domain 57 3e-08
CE29116 [O] KOG0941 E3 ubiquitin protein ligase 57 3e-08
Hs4557026 [S] KOG1426 FOG: RCC1 domain 57 5e-08
ECU04g1500 [S] KOG1426 FOG: RCC1 domain 57 5e-08
At3g53830 [S] KOG1426 FOG: RCC1 domain 56 9e-08
At5g16040 [S] KOG1426 FOG: RCC1 domain 55 2e-07
At3g26100 [S] KOG1426 FOG: RCC1 domain 55 2e-07
7295603 [S] KOG1426 FOG: RCC1 domain 55 2e-07
Hs13540582 [S] KOG1426 FOG: RCC1 domain 54 3e-07
At3g55580 [S] KOG1426 FOG: RCC1 domain 54 3e-07
At5g60870 [S] KOG1426 FOG: RCC1 domain 52 1e-06
7293028 [T] KOG1428 Inhibitor of type V adenylyl cyclases/Neuron... 51 2e-06
Hs19923519 [S] KOG1426 FOG: RCC1 domain 51 3e-06
YGL097w [S] KOG1426 FOG: RCC1 domain 49 8e-06
>YAL020c [S] KOG1426 FOG: RCC1 domain
Length = 333
Score = 219 bits (558), Expect = 5e-57
Identities = 132/359 (36%), Positives = 195/359 (53%), Gaps = 52/359 (14%)
Query: 9 FGSNGNGQLGVGHDEDLMLPQLSFQSD-GVGIKKVSCGGNHSLLLLEDGSLYWCGDNSSG 67
FGSNG QLG+GHDED+ PQ S D G ++K++CGGNHS++L DG+L CGDN G
Sbjct: 7 FGSNGQRQLGLGHDEDMDTPQRSVPGDDGAIVRKIACGGNHSVMLTNDGNLVGCGDNRRG 66
Query: 68 QCASSD-IKISLEWIP--IPGKFLDIACGWEVTIVIDEDGWVKTRGRG--DKGELGVPRL 122
+ S+ ++ +W P +P +D+ACGW+ T+++D DG V RG G + + VP L
Sbjct: 67 ELDSAQALRQVHDWRPVEVPAPVVDVACGWDTTVIVDADGRVWQRGGGCYEFTQQHVP-L 125
Query: 123 KHSTEWIDLFRCEDPKGSRCYATFQHCVVVVPEKIYGWGNNRKLQVCDDSALKIIEEPKV 182
+ E I ++ C FQ+ VVV ++YGWG+N K Q+ + + + ++EP +
Sbjct: 126 NSNDERIAVYGC-----------FQNFVVVQGTRVYGWGSNTKCQLQEPKS-RSLKEPVL 173
Query: 183 IYE-GDTSDIEMALGKDFTCVLSRTENKLIIKGSLAKELPELISQLSHDFGSIAKIDSMW 241
+Y+ G + +A+GKDF ++ + G L Q H+ + MW
Sbjct: 174 VYDTGSVAVDYVAMGKDFMVIVDEGGRIVHASGRLPTGFELKQQQKRHNLVVLC----MW 229
Query: 242 SSLHILTGERKLI-SIGRGSHGQFLEEPLPSETLDF-----VTGSEHGVVTTADMK---- 291
+S+H+ + S GRG+H Q P E LDF TGSEHG++TTA+ +
Sbjct: 230 TSIHLWNARLNTVESFGRGTHSQL----FPQERLDFPIVGVATGSEHGILTTANQEGKSH 285
Query: 292 ---VYCWGWGEHGNCGSLFKTETNPINDKSNVISPLNMIGKYEKVVSIFGGCATTWLVL 347
VYCWGWGEHGNCG ++ L ++G+Y +FGGCATTW+VL
Sbjct: 286 CYNVYCWGWGEHGNCGPQKASQPG-----------LQLVGQYSGKPRVFGGCATTWIVL 333
>SPAC10F6.04 [S] KOG1426 FOG: RCC1 domain
Length = 351
Score = 129 bits (325), Expect = 5e-30
Identities = 113/365 (30%), Positives = 177/365 (47%), Gaps = 43/365 (11%)
Query: 6 LLCFGSNGNGQLGVGHDEDLMLPQL-SFQSDGVGIKKVSCGGNHSLLLLEDGSLYWCGDN 64
LL GSNGN QLG+ +DED+ PQ+ F I+K+SCGGNH+LLL ED L+ CGDN
Sbjct: 2 LLSLGSNGNFQLGLNNDEDVYSPQIVPFDR---AIEKISCGGNHTLLLDEDSQLWACGDN 58
Query: 65 SSGQCASSDIKISLEWIPIPGKFLDI------------ACGWEVTIVIDED-GWVKTRGR 111
GQC ++K L + P+ +L I CGWE ++++ D V + G
Sbjct: 59 RKGQC-GYEVKEPL-YNPLSPDYLRIFTRVSHERWVFLTCGWEFSVIVHADRRRVCSCGE 116
Query: 112 GDKGELGVPRLKHS--TEWIDLFRCEDPKG-SRCYATFQHCVVVVPE-KIYGWGNNRKLQ 167
G GELG +S ID+ +D + A +H + V E +YG G+ RK Q
Sbjct: 117 GLSGELGQGNRSNSQGLREIDIPYLDDKEFIIDISAGLRHWICVTNEGNLYGCGDGRKGQ 176
Query: 168 VCDDSALKIIEEPKVIYEGDTSDIE-MALGKDFTCVLSRTENKLIIKG---SLAKELPEL 223
+ +K + KV + G + + G F+ VL T + +++ G ++A E
Sbjct: 177 L-GPVVMKTVN--KVSFLGRIEHAQAVVCGVQFSAVLQETGHVIVLGGEKWNVAAECDAW 233
Query: 224 ISQLSHDFGSIAKIDSMWSSLHILTGERKLISIGRGSHGQFLEEPLPSETLDFVTGSEHG 283
+ S SI I + WS+L +L+ E + + GR Q S+ + +G+EH
Sbjct: 234 QANNSELSSSICSISANWSTLSLLSTEGCVYAFGRCDRAQ-KAHTKASDIVQIASGTEHN 292
Query: 284 VVTTADMKVYCWGWGEHGNCGSLFKTETNPINDKSNVISPLNM-IGKYEKVVSIFGGCAT 342
++ T V +GW EHGN + +DK +V + + + +V+ G AT
Sbjct: 293 ILRTKKGSVLIYGWNEHGNASN---------DDKRDVYDAKTLQLPGWAYIVA--AGYAT 341
Query: 343 TWLVL 347
+W+V+
Sbjct: 342 SWIVI 346
>Hs6912330 [S] KOG1426 FOG: RCC1 domain
Length = 458
Score = 99.0 bits (245), Expect = 9e-21
Identities = 95/362 (26%), Positives = 143/362 (39%), Gaps = 54/362 (14%)
Query: 2 ASYELLCFGSNGNGQLGVGHDEDLMLPQ-LSFQSDGVGIKKVSCGGNHSLLLLEDGSLYW 60
A+ L +G+N GQLG+GH ED++LPQ L+ +++++ GG HS ++ + G L+
Sbjct: 13 AAAALFAWGANSYGQLGLGHKEDVLLPQQLNDFCKPRSVRRITGGGGHSAVVTDGGDLFV 72
Query: 61 CGDNSSGQCASSDIKISLEWIPIPGKF----LDIACGWEVTIVIDEDGWVKTRGRGDKGE 116
CG N GQ + + P F +ACGW+ TI++ E+G V + G G+
Sbjct: 73 CGLNKDGQLGLGHTEDIPYFTPCKSLFGCPIQQVACGWDFTIMLTENGQVLSCGSNSFGQ 132
Query: 117 LGVPRLKHSTEWIDLFRCEDPKGSRCYATFQHCVVVVPEKI-YGWGNNRK---LQVCDDS 172
LGVP K A +H V I + WG ++C
Sbjct: 133 LGVPHGPRRCVVPQAIELHKEKVVCIAAGLRHAVAATASGIVFQWGTGLASCGRRLCPGQ 192
Query: 173 ALKII---EEPKVIYEGDTSDIEMAL-GKDFTCVLSRTENKLI----IKGSLAKE----- 219
L + +EP + + S L G D + L+ + G LA E
Sbjct: 193 TLPLFFTAKEPSRVTGLENSKAMCVLAGSDHSASLTDAGEVYVWGSNKHGQLANEAAFLP 252
Query: 220 LPELISQLSHDFGSIAKIDSMWSSLHILTGERKLISIGRGSHGQ---------------- 263
+P+ I + I S W+ L T K+ + GR +GQ
Sbjct: 253 VPQKIEAHCFQNEKVTAIWSGWTHLVAQTETGKMFTWGRADYGQLGRKLETYEGWKLEKQ 312
Query: 264 --FLEEPLPSETL-----------DFVTGSEHGVVTTADMKVYCWGWGEHGNCGSLFKTE 310
FL P ++ + GSEH + + Y WGW EHG CG TE
Sbjct: 313 DSFLPCSRPPNSMPSSPHCLTGATEVSCGSEHNLAIIGGV-CYSWGWNEHGMCGD--GTE 369
Query: 311 TN 312
N
Sbjct: 370 AN 371
>At5g63860 [S] KOG1426 FOG: RCC1 domain
Length = 440
Score = 84.3 bits (207), Expect = 2e-16
Identities = 71/250 (28%), Positives = 113/250 (44%), Gaps = 15/250 (6%)
Query: 5 ELLCFGSNGNGQLGVGHDEDLMLPQLSFQSDGVGIKKVSCGGNHSLLLLEDGSLYWCGDN 64
E+ +G N NGQLG+G ED ++PQ +G+ IK V+ G H+ + EDG LY G
Sbjct: 140 EVQSWGRNQNGQLGLGDTEDSLVPQKIQAFEGIRIKMVAAGAEHTAAVTEDGDLYGWGWG 199
Query: 65 SSGQCASSD--IKISLEWIPIPG--KFLDIACGWEVTIVIDEDGWVKTRGRGDKGELGVP 120
G D ++ E + G K +ACGW TI + G + T G G+LG
Sbjct: 200 RYGNLGLGDRTDRLVPERVTSTGGEKMSMVACGWRHTISVSYSGALYTYGWSKYGQLGHG 259
Query: 121 RLKHSTEWIDLFRCEDPKGSRCYATFQHCVVVVPE-KIYGWGNNRKLQVCDDSALKIIEE 179
L+ L + S+ ++H + + + K+YGWG N+ QV + L
Sbjct: 260 DLEDHLIPHKLEALSNSFISQISGGWRHTMALTSDGKLYGWGWNKFGQVGVGNNLDQCSP 319
Query: 180 PKVIYEGDTSDIEMALGKDFTCVLSR----------TENKLIIKGSLAKELPELISQLSH 229
+V + D ++++ G T ++ T +L I S+ + P++I LS
Sbjct: 320 VQVRFPDDQKVVQVSCGWRHTLAVTERNNVFAWGRGTNGQLGIGESVDRNFPKIIEALSV 379
Query: 230 DFGSIAKIDS 239
D S I+S
Sbjct: 380 DGASGQHIES 389
Score = 67.0 bits (162), Expect = 4e-11
Identities = 85/340 (25%), Positives = 133/340 (39%), Gaps = 44/340 (12%)
Query: 1 MASYELLC-FGSNGNGQLGVGHDEDLMLPQLSFQSDGVGIKKVSCGGNHSLLLLEDG--- 56
+ S +++C +G +GQLG G ED P DG I V+CG +H++ + G
Sbjct: 30 LLSGDIVCSWGRGEDGQLGHGDAEDRPSPTQLSALDGHQIVSVTCGADHTVAYSQSGMEV 89
Query: 57 -SLYWCGDNSSGQCASSDIKISLEWIPIPGKFL------DIACGWEVTIVIDEDGWVKTR 109
S W G SSD+ + P+P K L IACG + + +G V++
Sbjct: 90 YSWGWGDFGRLGHGNSSDL-----FTPLPIKALHGIRIKQIACGDSHCLAVTMEGEVQSW 144
Query: 110 GRGDKGELGVPRLKHSTEWIDLFRCEDPKGSRCYATFQHCVVVVPE-KIYGWGNNRKLQV 168
GR G+LG+ + S + E + A +H V + +YGWG R +
Sbjct: 145 GRNQNGQLGLGDTEDSLVPQKIQAFEGIRIKMVAAGAEHTAAVTEDGDLYGWGWGRYGNL 204
Query: 169 -CDDSALKIIEEPKVIYEGDTSDIEMALGKDFTCVLSR---------TENKLIIKGSLAK 218
D +++ E +V G +A G T +S ++ + G L
Sbjct: 205 GLGDRTDRLVPE-RVTSTGGEKMSMVACGWRHTISVSYSGALYTYGWSKYGQLGHGDLED 263
Query: 219 EL-PELISQLSHDFGSIAKIDSMWSSLHILTGERKLISIGRGSHGQF------------- 264
L P + LS+ F I++I W LT + KL G GQ
Sbjct: 264 HLIPHKLEALSNSF--ISQISGGWRHTMALTSDGKLYGWGWNKFGQVGVGNNLDQCSPVQ 321
Query: 265 LEEPLPSETLDFVTGSEHGVVTTADMKVYCWGWGEHGNCG 304
+ P + + G H + T V+ WG G +G G
Sbjct: 322 VRFPDDQKVVQVSCGWRHTLAVTERNNVFAWGRGTNGQLG 361
>At1g27060 [S] KOG1426 FOG: RCC1 domain
Length = 386
Score = 77.8 bits (190), Expect = 2e-14
Identities = 95/377 (25%), Positives = 151/377 (39%), Gaps = 60/377 (15%)
Query: 9 FGSNGNGQLGVGHDEDLMLPQLSFQSDGVGIKKVSCGGNHSLLLLEDGSLYWCGDNSSGQ 68
+G+ +GQLG +D +LPQL + I ++CGG H + L G ++ G SSGQ
Sbjct: 20 WGAGTDGQLGTTKLQDELLPQLLSLTSLPSISMLACGGAHVIALTSGGKVFTWGRGSSGQ 79
Query: 69 CASSDI-KISLEWIPIPGKFLD------IACGWEVTIVIDEDGWVKTRGRGDKGELG-VP 120
DI I+L P F D A GW + + + G + T G G G+LG
Sbjct: 80 LGHGDILNITL---PKLVSFFDDSVITQAAAGWSHSGFVSDSGCIFTCGNGSFGQLGHGD 136
Query: 121 RLKHST-EWIDLFRCEDPKGSRCYATFQHCVVV-VPEKIYGWGNNRKLQV---------- 168
L ST + F + K C +H +V+ ++ G+G+ ++ Q+
Sbjct: 137 TLSLSTPAKVSHFNNDSVKMVAC--GMRHSLVLFAGNQVCGFGSGKRGQLGFSSDRIKSV 194
Query: 169 ---CDDSALKIIEEPKVIYEGDTSDIEMALGKDFTCVLSRTENKLIIKGSLAKELPELIS 225
C S LK +E ++ GD S A G+ F+ + G L S
Sbjct: 195 NLPCVVSGLKDVEVVRISANGDHSAAISADGQFFSW------GRGFCGGPDVHAPQSLPS 248
Query: 226 QLSHDFGSIAKIDSMWSSLHILTGERKLISIGRGSHGQ------------FLEEPLPS-- 271
L S ++ W+ +LT + ++ +G + Q L E +P
Sbjct: 249 PL-----SFREVAVGWNHALLLTVDGEVFKLGSTLNKQPEKQQLQIDSSEALFEKVPDFD 303
Query: 272 --ETLDFVTGSEHGVVTTADMKVYCWGWGEHGNCGSLFKTETNPINDKSNVISPLNMIGK 329
+ + G+EH T + +V WGWGEHG G N + S + L I
Sbjct: 304 GVKVMQIAAGAEHSAAVTENGEVKTWGWGEHGQLGL-----GNTNDQTSPELVSLGSIDL 358
Query: 330 YEKVVSIFGGCATTWLV 346
K + ++ G T+ V
Sbjct: 359 RTKEIKVYCGSGFTYAV 375
>CE07026 [S] KOG1426 FOG: RCC1 domain
Length = 1098
Score = 75.5 bits (184), Expect = 1e-13
Identities = 87/337 (25%), Positives = 139/337 (40%), Gaps = 40/337 (11%)
Query: 2 ASYELLCFGSNGNGQLGVGHDEDLM-LPQLSFQSDGVGIKKVSCGGNHSLLLLEDGSLYW 60
+S +L +G N GQ GVGH + L Q+ D I+K++CG HS + DGSL+
Sbjct: 499 SSGQLSAWGGNRFGQCGVGHSFRIANLHQVD--GDWPAIEKIACGQFHSAFICSDGSLWT 556
Query: 61 CGDNSSGQCASSDIKISLEWIP-----IPGKFLDIACGWEVTIVIDEDGWVKTRGRGDKG 115
G GQ S + +P + K IACG T+V+ + G V G G G
Sbjct: 557 FGWGVWGQLGHGGRNNSNQLVPTRVNGLICKVTQIACGRAHTVVLTDTGRVLVCGSGSYG 616
Query: 116 ELGV-PRLKHSTEWIDLFRCEDPKGSRCYATFQHCVVVVPE--KIYGWGNNRKLQVCDDS 172
++GV +K + L P R AT + + + E +++ WG N +
Sbjct: 617 QMGVDDDIKKVFAFTPL--PLGPLRVRDIATHYYHSICITEDNRVFEWGRNPQELKMRMF 674
Query: 173 ALKIIEEPKVIYEGDTSDIEMALGKDFTCVLSRTENKLIIKGSLAKELPEL---ISQLSH 229
+K I ++ D S S + + +L E+P + ++ H
Sbjct: 675 VMKKIRSAQLKNTEDPSSPSP----------STNGSTPRVNLNLPAEIPREDLGLREVKH 724
Query: 230 DF-GSIAKIDSMWSSLHILTGERKLISIGRG-----SHGQFLE--------EPLPSETLD 275
G+I + S ++T E L + G+G HG E EP ++ ++
Sbjct: 725 FLDGNIVSVACGLSHSALITSEGTLYTWGKGLDYQLGHGNKNERMEPHQVFEPNGAKWVN 784
Query: 276 FVTGSEHGVVTTADMKVYCWGWGEHGNCGSLFKTETN 312
G+ H + +T D V+ WG + G CG L K N
Sbjct: 785 VSLGNNHTIASTDDGSVFAWGKNDFGQCGVLTKKNGN 821
>7296072 [S] KOG1426 FOG: RCC1 domain
Length = 355
Score = 65.5 bits (158), Expect = 1e-10
Identities = 73/328 (22%), Positives = 137/328 (41%), Gaps = 57/328 (17%)
Query: 39 IKKVSCGGNHSLLLLEDGSLYWCGDNSSGQCA-SSDIKISLEWIPIPGKFLD------IA 91
++ + GG H L+L G ++ CG N+ GQ S + E+ IP ++ I+
Sbjct: 16 VRLIRGGGGHVLILDTSGRIHACGWNNRGQLGLDSTEECHSEFKMIPTEYFGDVPVETIS 75
Query: 92 CGWEVTIVIDEDGWVKTRGRGDKGELGVPRLKHSTEW----IDLFRCEDPKGSRCYATFQ 147
CGW+++ I + G +LG+ + + + L R E+P R +
Sbjct: 76 CGWDISGAITLTKRLFVWGSNAFQQLGICQRGFTAVRRPMPVKLPR-EEP-AQRISFGLR 133
Query: 148 HCVVVVPE-KIYGWGNNRKLQVCDDSALKIIEEPKVIYEGDTSDIEMALGKDFTCV-LSR 205
HC V+ + KIY +G +L++ D +++ ++ +T I++ + V +S
Sbjct: 134 HCAVLTQDNKIYVFG---RLRIMDPPPIELDITATCLHRCNTVKIQVHNPNELRIVSISS 190
Query: 206 TENKLIIKGSLAKEL-----PELISQLSHDFGS---------IAKIDSMWSSLHILTGER 251
+N +++K + E +++ + FG + ++ W+ +
Sbjct: 191 GQNHMVLKCADLSETGGGSTKRILTLGDNKFGQSNAFQFEEDVRQLAVGWTHNAAVLKNN 250
Query: 252 KLISIGRGSHGQF----------------LEEPLPSETLDFVTGSEHGVVTTADMKVYCW 295
+++ GR +GQ L+ P G+EHG++ T +VY W
Sbjct: 251 EILVWGRNCYGQLGMGSFSEQQAIPTPLRLKLPEDQGPARIHMGAEHGLLRTTAGEVYTW 310
Query: 296 GWGEHGNCGSLFKTETNPINDKSNVISP 323
GW EHGNCG+ N NV +P
Sbjct: 311 GWNEHGNCGN---------NSTENVCTP 329
>Hs4506581_1 [S] KOG1426 FOG: RCC1 domain
Length = 524
Score = 63.9 bits (154), Expect = 3e-10
Identities = 53/178 (29%), Positives = 80/178 (44%), Gaps = 4/178 (2%)
Query: 10 GSNGNGQLGVGHDEDL-MLPQLSFQSDGVGIKKVSCGGNHSLLLLEDGSLYWCGDNSSGQ 68
G N GQLG+G E+ +SF + IK++S G N S L EDG L+ GDNS GQ
Sbjct: 112 GGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDGRLFMWGDNSEGQ 171
Query: 69 CASSDIK--ISLEWIPIPGKFLDIACGWEVTIVIDEDGWVKTRGRGDKGELGVPRLKHST 126
++ + + I I+CG+ + + DG + G + G+LG+P
Sbjct: 172 IGLKNVSNVCVPQQVTIGKPVSWISCGYYHSAFVTTDGELYVFGEPENGKLGLPNQLLGN 231
Query: 127 EWIDLFRCEDP-KGSRCYATFQHCVVVVPEKIYGWGNNRKLQVCDDSALKIIEEPKVI 183
E P K + +H VV+ +Y +G + Q+ + L EPKVI
Sbjct: 232 HRTPQLVSEIPEKVIQVACGGEHTVVLTENAVYTFGLGQFGQLGLGTFLFETSEPKVI 289
Score = 60.1 bits (144), Expect = 5e-09
Identities = 72/317 (22%), Positives = 125/317 (38%), Gaps = 44/317 (13%)
Query: 5 ELLCFGSNGNGQLGVGHDEDLMLPQLSFQSDGVGIKKVSCGGNHSLLLLEDGSLYWCGDN 64
+L FGSN GQLG+G + P +K +CG NH+L+ E G++Y G N
Sbjct: 55 KLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHTLVSTEGGNVYATGGN 114
Query: 65 SSGQCASSDIKIS-----LEWIPIPGKFLDIACGWEVTIVIDEDGWVKTRGRGDKGELGV 119
+ GQ D + + + K ++ G + + EDG + G +G++G+
Sbjct: 115 NEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGL 174
Query: 120 PRLKHSTEWIDLFRCEDPKGSRCYATFQHCVVVVPE---KIYGWGNNRKLQVCDDSALKI 176
+ + + + C + H V + ++G N KL + + L
Sbjct: 175 KNVSNVCVPQQVTIGKPVSWISC--GYYHSAFVTTDGELYVFGEPENGKLGL-PNQLLGN 231
Query: 177 IEEPKVIYEGDTSDIEMALGKDFTCVLSRTENKLIIKGSLAKELPELISQLSHDFGSIAK 236
P+++ E I++A G + T VL TEN + G FG +
Sbjct: 232 HRTPQLVSEIPEKVIQVACGGEHTVVL--TENAVYTFG-------------LGQFGQLGL 276
Query: 237 IDSMWSSLHILTGERKLISIGRGSHGQFLEEPLPSETLDFVT-GSEHGVVTTADMKVYCW 295
++ T E K+I E + +T+ +++ G H + T +Y +
Sbjct: 277 GTFLFE-----TSEPKVI------------ENIRDQTISYISCGENHTALITDIGLMYTF 319
Query: 296 GWGEHGNCGSLFKTETN 312
G G HG G + TN
Sbjct: 320 GDGRHGKLGLGLENFTN 336
>7297063 [S] KOG1427 Uncharacterized conserved protein contains RCC1 domain
Length = 487
Score = 63.5 bits (153), Expect = 4e-10
Identities = 38/118 (32%), Positives = 64/118 (54%), Gaps = 7/118 (5%)
Query: 7 LCFGSNGNGQLGVGHDEDLM-LPQLSFQSDGVGIKKVSCGGNHSLLLLEDGSLYWCGDNS 65
L FG N +GQLG+ D L P + + + I + + G +H+L L + G++Y CG+N
Sbjct: 138 LGFGRNPSGQLGLSQDIKLAEKPTIIPALEQLNIVQAAVGRHHTLFLTDTGTVYACGENK 197
Query: 66 SGQCASSDIKISLEWIPIPGKF-----LDIACGWEVTIVIDEDGWVKTRGRGDKGELG 118
SGQC + ++ + P P + + I CG E ++++D G + T G + G+LG
Sbjct: 198 SGQCGVGNTHANI-YSPTPINYRGPPIIRIGCGAEFSVILDIKGSLHTFGLPEYGQLG 254
>Hs7657152 [O] KOG0941 E3 ubiquitin protein ligase
Length = 1050
Score = 62.4 bits (150), Expect = 1e-09
Identities = 50/174 (28%), Positives = 80/174 (45%), Gaps = 26/174 (14%)
Query: 6 LLCFGSNGNGQLGVGHDEDLML--PQLSFQSDGVGIKKVSCGGNHSLLLLEDGSLYWCGD 63
+LC+G GQ G+ + ++ PQ+ +K+V+CGGNHS+ LLEDG +Y CG
Sbjct: 1 MLCWGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGNHSVFLLEDGEVYTCGL 60
Query: 64 NSSGQCASSDIKISLEWIP--IPGKFLDIACGWEVTIVIDEDGWVKTRGRGDKGELG--- 118
N+ GQ E I + +ACG ++ + + G + + G G G+LG
Sbjct: 61 NTKGQLGHEREGNKPEQIGALADQHIIHVACGESHSLALSDRGQLFSWGAGSDGQLGLMT 120
Query: 119 ------VPRL--KHSTEWIDLFRCEDPKGSRCYATFQHCVVVVPE-KIYGWGNN 163
VPRL K + + I C + HC+ + + + + WG N
Sbjct: 121 TEDSVAVPRLIQKLNQQTILQVSCGN----------WHCLALAADGQFFTWGKN 164
Score = 59.3 bits (142), Expect = 8e-09
Identities = 47/167 (28%), Positives = 75/167 (44%), Gaps = 7/167 (4%)
Query: 2 ASYELLCFGSNGNGQLGVGHD-EDLMLPQLSFQSDGVGIKKVSCGGNHSLLLLEDGSLYW 60
A + +G N +GQLG+G + PQ +G+ + +V+ GG HS L G+++
Sbjct: 154 ADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFG 213
Query: 61 CGDNSSGQCASSDIKISLEWIPI----PGKFLDIACGWEVTIVIDEDGWVKTRGRGDKGE 116
G N++GQ SD K + K + I+CG E T V+ + G V T G G G+
Sbjct: 214 WGMNNAGQLGLSDEKDRESPCHVKLLRTQKVVYISCGEEHTAVLTKSGGVFTFGAGSCGQ 273
Query: 117 LGVPRLKHSTEWIDLFRCEDPKGSRCYATFQHCVVVVPEK--IYGWG 161
LG + + + ++ QH + VP IY +G
Sbjct: 274 LGHDSMNDEVNPRRVLELMGSEVTQIACGRQHTLAFVPSSGLIYAFG 320
Score = 49.7 bits (117), Expect = 6e-06
Identities = 40/125 (32%), Positives = 59/125 (47%), Gaps = 14/125 (11%)
Query: 5 ELLCFGSNGNGQLGVGHDED-LMLPQLSFQSDGVGIKKVSCGGNHSLLLLEDGSLYWCGD 63
+L +G+ +GQLG+ ED + +P+L + + I +VSCG H L L DG + G
Sbjct: 104 QLFSWGAGSDGQLGLMTTEDSVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGK 163
Query: 64 NSSGQC---------ASSDIKISLEWIPIPGKFLDIACGWEVTIVIDEDGWVKTRGRGDK 114
NS GQ AS SLE IP+ +A G + + G V G +
Sbjct: 164 NSHGQLGLGKEFPSQASPQRVRSLEGIPL----AQVAAGGAHSFALSLSGAVFGWGMNNA 219
Query: 115 GELGV 119
G+LG+
Sbjct: 220 GQLGL 224
>Hs7705931 [O] KOG0941 E3 ubiquitin protein ligase
Length = 1024
Score = 60.8 bits (146), Expect = 3e-09
Identities = 40/121 (33%), Positives = 59/121 (48%), Gaps = 5/121 (4%)
Query: 3 SYELLCFGSNGNGQLGVGHDEDLMLPQLSFQSDGVGIKKVSCGGNHSLLLLEDGSLYWCG 62
S + +G N GQLG+GH E P L D ++ V+CGG+HS LL +DG L+ G
Sbjct: 209 SGNIYSWGKNECGQLGLGHTESKDDPSLIEGLDNQKVEFVACGGSHSALLTQDGLLFTFG 268
Query: 63 DNSSGQ----CASSDIKISLEWIPIPGKFLDIACG-WEVTIVIDEDGWVKTRGRGDKGEL 117
GQ ++++ L + + IACG W + + G V + G G G+L
Sbjct: 269 AGKHGQLGHNSTQNELRPCLVAELVGYRVTQIACGRWHTLAYVSDLGKVFSFGSGKDGQL 328
Query: 118 G 118
G
Sbjct: 329 G 329
Score = 56.6 bits (135), Expect = 5e-08
Identities = 39/119 (32%), Positives = 57/119 (47%), Gaps = 5/119 (4%)
Query: 5 ELLCFGSNGNGQLGVGHD-EDLMLPQLSFQSDGVGIKKVSCGGNHSLLLLEDGSLYWCGD 63
EL +G N +GQLGVG PQ+ GV + ++S G HS+ L G++Y G
Sbjct: 158 ELFAWGQNLHGQLGVGRKFPSTTTPQIVEHLAGVPLAQISAGEAHSMALSMSGNIYSWGK 217
Query: 64 NSSGQCASSDIKISLEWIPIPG----KFLDIACGWEVTIVIDEDGWVKTRGRGDKGELG 118
N GQ + + I G K +ACG + ++ +DG + T G G G+LG
Sbjct: 218 NECGQLGLGHTESKDDPSLIEGLDNQKVEFVACGGSHSALLTQDGLLFTFGAGKHGQLG 276
>7292061 [O] KOG0941 E3 ubiquitin protein ligase
Length = 1057
Score = 59.7 bits (143), Expect = 6e-09
Identities = 37/118 (31%), Positives = 57/118 (47%), Gaps = 4/118 (3%)
Query: 5 ELLCFGSNGNGQLGVG--HDEDLMLPQLSFQSDGVGIKKVSCGGNHSLLLLEDGSLYWCG 62
EL C+GS +GQLG+G DE ++ P + +++V+CG H+L L G +Y CG
Sbjct: 6 ELYCWGSTSHGQLGLGGIEDEQILTPSQIPWTPDTAVQQVACGHRHTLFLTATGKVYACG 65
Query: 63 DNSSGQCASSDIKISLEWIPIPGKF--LDIACGWEVTIVIDEDGWVKTRGRGDKGELG 118
N Q IP + + I CG ++ + + G V + G D G+LG
Sbjct: 66 SNDYSQLGHDLPTKRPLLIPELQDYVIIQICCGSRHSLALSDWGQVLSWGDNDCGQLG 123
Score = 59.7 bits (143), Expect = 6e-09
Identities = 42/123 (34%), Positives = 63/123 (51%), Gaps = 11/123 (8%)
Query: 5 ELLCFGSNGNGQLGVGHDEDLM---LPQLSFQSDGVGIKKVSCGGNHSLLLLEDGSLYWC 61
EL +GSN GQLGV DL P G+ + ++CGGNHS L+ + G+++
Sbjct: 163 ELYSWGSNIYGQLGVNSPNDLTHCNYPLRLTTLLGIPLAAIACGGNHSFLISKSGAVFGW 222
Query: 62 GDNSSGQCASSD-----IKISLEWIPIPG-KFLDIACGWEVTIVIDEDGWVKTRGRGDKG 115
G N+ GQ +D L+ + G +F +ACG E ++ + +G V T G G G
Sbjct: 223 GRNNCGQLGLNDETNRSYPTQLKTLRTLGVRF--VACGDEFSVFLTNEGGVFTCGAGAYG 280
Query: 116 ELG 118
+LG
Sbjct: 281 QLG 283
Score = 53.9 bits (128), Expect = 3e-07
Identities = 41/127 (32%), Positives = 65/127 (50%), Gaps = 16/127 (12%)
Query: 5 ELLCFGSNGNGQLGVGHDEDLM-LPQLSFQSDGVGIKKVSCGGNHSLLLLEDGSLYWCGD 63
++L +G N GQLG D++++ LP++ Q + +++CG NHSL L G LY G
Sbjct: 110 QVLSWGDNDCGQLGHATDKEIVQLPKVVRQLVTKTVVQIACGNNHSLALTSCGELYSWGS 169
Query: 64 NSSGQC---ASSDIK--------ISLEWIPIPGKFLDIACGWEVTIVIDEDGWVKTRGRG 112
N GQ + +D+ +L IP+ IACG + +I + G V GR
Sbjct: 170 NIYGQLGVNSPNDLTHCNYPLRLTTLLGIPLAA----IACGGNHSFLISKSGAVFGWGRN 225
Query: 113 DKGELGV 119
+ G+LG+
Sbjct: 226 NCGQLGL 232
>Hs4758520 [S] KOG1426 FOG: RCC1 domain
Length = 4834
Score = 58.2 bits (139), Expect = 2e-08
Identities = 52/202 (25%), Positives = 91/202 (44%), Gaps = 18/202 (8%)
Query: 2 ASYELLCFGSNGNGQLGVGHDEDLMLPQLSFQSDGVGIKKVSCGGN--HSLLLLEDGSLY 59
A EL +G G+LG G ED +P L G+ + V+CG +L + E+G ++
Sbjct: 568 AEGELYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDVACGSGDAQTLAVTENGQVW 627
Query: 60 WCGDNSSGQ--------CASSDIKISLEWIPIPGKFLDIACGWEVTIVIDEDGWVKTRGR 111
GD G+ C + + L+ + + + + CG + +I + +DG V + G+
Sbjct: 628 SWGDGDYGKLGRGGSDGCKTPKLIEKLQDLDV----VKVRCGSQFSIALTKDGQVYSWGK 683
Query: 112 GDKGELGVPRLKHSTEWIDLFRCEDPKGSRCYATFQHCVVVVPE-KIYGWGNNRKLQVCD 170
GD LG +H L + K A HC+ + + +++ WG+N + Q D
Sbjct: 684 GDNQRLGHGTEEHVRYPKLLEGLQGKKVIDVAAGSTHCLALTEDSEVHSWGSNDQCQHFD 743
Query: 171 DSALKIIE-EPKVIYEGDTSDI 191
L++ + EP + DT I
Sbjct: 744 --TLRVTKPEPAALPGLDTKHI 763
Score = 55.5 bits (132), Expect = 1e-07
Identities = 45/189 (23%), Positives = 84/189 (43%), Gaps = 8/189 (4%)
Query: 2 ASYELLCFGSNGNGQLGVGHDEDLMLPQLSFQSDGVGIKKVSCGGN--HSLLLLEDGSLY 59
A+ +L +G G+LG ED + P+L G + ++CG +L L +D +++
Sbjct: 4108 AAGDLYTWGKGRYGRLGHSDSEDQLKPKLVEALQGHRVVDIACGSGDAQTLCLTDDDTVW 4167
Query: 60 WCGDNSSGQC---ASSDIKISLEWIPIPG-KFLDIACGWEVTIVIDEDGWVKTRGRGDKG 115
GD G+ S K+ ++ + G + + CG + ++ + + G V T G+GD
Sbjct: 4168 SWGDGDYGKLGRGGSDGCKVPMKIDSLTGLGVVKVECGSQFSVALTKSGAVYTWGKGDYH 4227
Query: 116 ELGVPRLKHSTEWIDLFRCEDPKGSRCYATFQHCVVVVPE-KIYGWGNNRKLQVCDDSAL 174
LG H + + K HCV + ++Y WG+N + Q+ D
Sbjct: 4228 RLGHGSDDHVRRPRQVQGLQGKKVIAIATGSLHCVCCTEDGEVYTWGDNDEGQL-GDGTT 4286
Query: 175 KIIEEPKVI 183
I+ P+++
Sbjct: 4287 NAIQRPRLV 4295
>Hs4557445 [S] KOG1426 FOG: RCC1 domain
Length = 551
Score = 57.4 bits (137), Expect = 3e-08
Identities = 46/170 (27%), Positives = 74/170 (43%), Gaps = 15/170 (8%)
Query: 5 ELLCFGSNGNGQLGVGHDEDLMLP-QLSFQSDGVGIKKVSCGGNHSLLLLEDGSLYWCGD 63
E+ +G N QLG G ++P +S + +V+CG HSL+L DG ++ G
Sbjct: 119 EVFTWGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGY 178
Query: 64 NSSGQCASSDIKISLEWIPIPGK---------FLDIACGWEVTIVIDEDGWVKTRGRGDK 114
N+SGQ S S PIP + + IACG + + + G V G
Sbjct: 179 NNSGQVGSG----STVNQPIPRRVTGCLQNKVVVTIACGQMCCMAVVDTGEVYVWGYNGN 234
Query: 115 GELGVPRLKHSTEWIDLFRCEDPKGSRCYATFQHCVVVVPE-KIYGWGNN 163
G+LG+ + + + + R + H +V+ E ++Y WG N
Sbjct: 235 GQLGLGNSGNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQVYAWGAN 284
Score = 54.7 bits (130), Expect = 2e-07
Identities = 40/139 (28%), Positives = 67/139 (47%), Gaps = 13/139 (9%)
Query: 5 ELLCFGSNGNGQLGVGHDEDLMLPQLSFQSDGVGIKKVSCGGNHSLLLLEDGSLYWCGDN 64
E+ +G NGNGQLG+G+ + P G+ +++V+CG H+L+L ++G +Y G N
Sbjct: 225 EVYVWGYNGNGQLGLGNSGNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQVYAWGAN 284
Query: 65 SSGQCASSDIKISLEWIPI---PGKFLDI-ACGWEVTIVIDEDG-----WVKTRGRGDKG 115
S GQ + + P+ + ++I AC T G W + RG+
Sbjct: 285 SYGQLGTGNKSNQSYPTPVTVEKDRIIEIAACHSTHTSAAKTQGGHVYMWGQCRGQ---- 340
Query: 116 ELGVPRLKHSTEWIDLFRC 134
+ +P L H + D+F C
Sbjct: 341 SVILPHLTHFSCTDDVFAC 359
>CE29116 [O] KOG0941 E3 ubiquitin protein ligase
Length = 1019
Score = 57.4 bits (137), Expect = 3e-08
Identities = 39/125 (31%), Positives = 60/125 (47%), Gaps = 10/125 (8%)
Query: 5 ELLCFGSNGNGQLGVGHDED-LMLPQLSFQS----DGVGIKKVSCGGNHSLLLLEDGSLY 59
ELL G G GQLGV E + +P+ + DG + V+CG H++ L +DG ++
Sbjct: 4 ELLGCGHTGEGQLGVRLSESTIQVPERIIGAPNDMDGTAVTSVTCGEQHTVFLTKDGKMW 63
Query: 60 WCGDNSSGQCA-SSDIKISLEWIPI----PGKFLDIACGWEVTIVIDEDGWVKTRGRGDK 114
G N GQ S + S P+ K + I+ G T+ + +DG V G +
Sbjct: 64 SVGSNMDGQLGRGSRTEGSFSIYPVSWTSSAKIIQISAGRSHTVSVTDDGRVFAWGSNEH 123
Query: 115 GELGV 119
G+LG+
Sbjct: 124 GQLGM 128
>Hs4557026 [S] KOG1426 FOG: RCC1 domain
Length = 4861
Score = 56.6 bits (135), Expect = 5e-08
Identities = 36/112 (32%), Positives = 60/112 (53%), Gaps = 5/112 (4%)
Query: 5 ELLCFGSNGNGQLGVGHDEDLMLPQLSFQSDGVGIKKVSCGGNHSLLLLEDGSLYWC-GD 63
+L FG+ G+LG+G+ + LP+ +G I +V+CG NH+L + DGS+ W GD
Sbjct: 4154 KLFTFGNGDYGRLGLGNTSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGD 4213
Query: 64 NSSGQ--CASSDIKISLEWIPI--PGKFLDIACGWEVTIVIDEDGWVKTRGR 111
G+ +S K S + I + +ACG + ++ + +DG V T G+
Sbjct: 4214 GDYGKLGLGNSTAKSSPQKIDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQ 4265
Score = 53.5 bits (127), Expect = 4e-07
Identities = 38/126 (30%), Positives = 60/126 (47%), Gaps = 10/126 (7%)
Query: 9 FGSNGNGQLGVGHDEDLMLPQLSFQSDGVGIKKVSCGGNHSLLLLEDGSLYWCGDN---- 64
FG G+LG+G+ PQ G+GIKKV+CG S+ L +DG +Y G +
Sbjct: 4211 FGDGDYGKLGLGNSTAKSSPQKIDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIG 4270
Query: 65 -SSGQCASSDIKISLEWIPIPGKFL--DIACGWEVTIVIDEDGWVKTRGRGDKGELGVPR 121
G+ + + + IP+ + D+A G E T+ + +G V G +G+LG+
Sbjct: 4271 LPEGRARNHN---RPQQIPVLAGVIIEDVAVGAEHTLALASNGDVYAWGSNSEGQLGLGH 4327
Query: 122 LKHSTE 127
H E
Sbjct: 4328 TNHVRE 4333
Score = 50.8 bits (120), Expect = 3e-06
Identities = 50/209 (23%), Positives = 90/209 (42%), Gaps = 8/209 (3%)
Query: 3 SYELLCFGSNGNGQLGVGHDEDLMLPQLSFQSDGVGIKKVSCGGNHSLLLLEDGSLYWCG 62
S E+ +G G+LG G+ + P+ G + ++SCG HS ++ DG L+ G
Sbjct: 4100 SGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFG 4159
Query: 63 DNSSGQCA---SSDIKISLEWIPIPG-KFLDIACGWEVTIVIDEDG-WVKTRGRGDKGEL 117
+ G+ +S+ K+ + G + +ACG T+ + DG V G GD G+L
Sbjct: 4160 NGDYGRLGLGNTSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKL 4219
Query: 118 GV--PRLKHSTEWIDLFRCEDPKGSRCYATFQHCVVVVPEKIYGWGNNRKLQVCDDSALK 175
G+ K S + ID+ K C F + +Y +G +R + + + A
Sbjct: 4220 GLGNSTAKSSPQKIDVLCGIGIKKVACGTQFS-VALTKDGHVYTFGQDRLIGLPEGRARN 4278
Query: 176 IIEEPKVIYEGDTSDIEMALGKDFTCVLS 204
++ ++A+G + T L+
Sbjct: 4279 HNRPQQIPVLAGVIIEDVAVGAEHTLALA 4307
>ECU04g1500 [S] KOG1426 FOG: RCC1 domain
Length = 440
Score = 56.6 bits (135), Expect = 5e-08
Identities = 39/115 (33%), Positives = 58/115 (49%), Gaps = 5/115 (4%)
Query: 9 FGSNGNGQLGVGHD-EDLMLP-QLSFQSDGVGIKKVSCGGNHSLLLLEDGSLYWCGDNSS 66
FGSN QLG+G D E +P +LSF D + + KV CG H+L+L DG LY G N
Sbjct: 87 FGSNAISQLGLGEDAESTHVPTRLSF-FDKMSLTKVRCGSLHTLVLDSDGMLYSWGCNDE 145
Query: 67 GQCASSDIKISLEWIPIPGKFLDIACGWEVTIVIDEDGWVKTRG--RGDKGELGV 119
G + + + + + K +D+ CG +++ + G V G R G G+
Sbjct: 146 GALGRDGDESTPQRVCLDEKIVDMDCGASISVALTSRGHVYVWGTFRSTNGTFGL 200
Score = 51.6 bits (122), Expect = 2e-06
Identities = 54/209 (25%), Positives = 86/209 (40%), Gaps = 14/209 (6%)
Query: 6 LLCFGSNGNGQLGVGHDEDLMLPQLSFQSDGVGIKK--------VSCGGNHSLLLLEDGS 57
+ FGSN G+LG E L L + K+ +SCG NH + L DG
Sbjct: 237 IFTFGSNEFGELGRRTSERNKLRALIPDAVTTPRKRLRNYRFRSISCGLNHIIALNTDGE 296
Query: 58 LYWCGDNSSGQCASSDIKISLEWIPIP-GKFLDIACGWEVTIVIDEDGWVKTRGRGDKGE 116
Y G N GQ + + +P +A G ++ + DG + GR +G+
Sbjct: 297 AYCWGSNLYGQLGHDKAESTFNKYKVPLDGIRQVAGGENHSLFVTIDGTLYGCGRNKEGQ 356
Query: 117 LGVPRLKHSTEWIDLFRCEDPKGSRCYATFQHCVVVVPEKIYGWGNNRKLQVCDDSALKI 176
LG+ ++ + L E + R Y +F C V ++Y WG + + +
Sbjct: 357 LGIQSVEAVRTPMKL-SIEHVETVRSYNSFNIC--RVGNELYSWGTGFNGALGHEEETIL 413
Query: 177 IEEPKVIYEGDTSDIEMALGKDFTCVLSR 205
I PK I I+ +G DF+ V++R
Sbjct: 414 I--PKKIPFDFPEVIDFDVGNDFSVVVTR 440
>At3g53830 [S] KOG1426 FOG: RCC1 domain
Length = 487
Score = 55.8 bits (133), Expect = 9e-08
Identities = 37/104 (35%), Positives = 54/104 (51%), Gaps = 7/104 (6%)
Query: 5 ELLCFGSNGNGQLGVGHDEDLMLPQL--SFQSDGVGIKKVSCGGNHSLLLLEDGSLYWCG 62
++ FG N GQLG G D +LP+L +G K VSCG HS +L EDG L G
Sbjct: 382 KVYAFGGNQFGQLGTGTDHAEILPRLLDGQNLEGKHAKAVSCGARHSAVLAEDGQLLCWG 441
Query: 63 DNSSGQCA---SSDIKISLEWIPIPG-KFLDIACGWEVTIVIDE 102
N GQ ++D I + + + G + +ACGW T+++ +
Sbjct: 442 WNKYGQLGLGDTNDRNIPTQ-VQLDGCRLRKVACGWWHTLLLGD 484
>At5g16040 [S] KOG1426 FOG: RCC1 domain
Length = 396
Score = 54.7 bits (130), Expect = 2e-07
Identities = 35/122 (28%), Positives = 57/122 (46%), Gaps = 6/122 (4%)
Query: 6 LLCFGSNGNGQLGVGHDEDLMLPQLSFQSDGVGIKKVSCGGNHSLLLLEDGSLYWCGDNS 65
L +G+N GQLG G + P D + + ++ GG HS L +G +Y G
Sbjct: 217 LWAWGNNEYGQLGTGDTQPRSYPIPVQGLDDLTLVDIAAGGWHSTALTNEGEVYGWGRGE 276
Query: 66 SGQCASSDIKISLEWIP-----IPGK-FLDIACGWEVTIVIDEDGWVKTRGRGDKGELGV 119
G+ D S + +P + G+ + ++CG ++ + DG + + GRGD G LG
Sbjct: 277 HGRLGFGDNDKSSKMLPQKVNLLAGEDIIQVSCGGTHSVALTRDGRIFSFGRGDHGRLGY 336
Query: 120 PR 121
R
Sbjct: 337 GR 338
>At3g26100 [S] KOG1426 FOG: RCC1 domain
Length = 532
Score = 54.7 bits (130), Expect = 2e-07
Identities = 43/137 (31%), Positives = 62/137 (44%), Gaps = 19/137 (13%)
Query: 5 ELLCFGSNGNGQLGVGHDEDLMLPQLSFQSDGVGIKKVSCGGNHSLLLLEDGSLYWCGDN 64
E+ FG N +GQLG GH ED Q GV I + + G ++L+ +DG +Y CG
Sbjct: 163 EVYTFGYNNSGQLGHGHTEDEARIQPVRSLQGVRIIQAAAGAARTMLISDDGKVYACGKE 222
Query: 65 SSGQC----------ASSDIKISLEWIPIPGKFLDIACGWEVTIVIDEDGWVKTRGRGDK 114
S G+ + + SL+ I + + A G T V+ +G V T G+
Sbjct: 223 SFGEAEYGGQGTKPVTTPQLVTSLKNIFV----VQAAIGNYFTAVLSREGKVYTFSWGND 278
Query: 115 GELGVPRLKHSTEWIDL 131
G LG H TE D+
Sbjct: 279 GRLG-----HQTEAADV 290
>7295603 [S] KOG1426 FOG: RCC1 domain
Length = 4669
Score = 54.7 bits (130), Expect = 2e-07
Identities = 46/189 (24%), Positives = 84/189 (44%), Gaps = 8/189 (4%)
Query: 2 ASYELLCFGSNGNGQLGVGHDEDLMLPQLSFQSDGVGIKKVSCGGN--HSLLLLEDGSLY 59
AS +L +G G+LG G ED + P+L G ++CG +L + +D +++
Sbjct: 4205 ASGHVLTWGKGRYGRLGHGDSEDQLRPKLVEALLGYRAIDIACGSGDAQTLCITDDDNVW 4264
Query: 60 WCGDNSSGQC---ASSDIKISLEWIPIPG-KFLDIACGWEVTIVIDEDGWVKTRGRGDKG 115
GD G+ S K+ + + G + + CG + ++ + + G V T G+GD
Sbjct: 4265 SWGDGDYGKLGRGGSDGCKLPYKIESLAGLGVVKVECGSQFSVALTKSGAVYTWGKGDFH 4324
Query: 116 ELGVPRLKHSTEWIDLFRCEDPKGSRCYATFQHCVVVVPE-KIYGWGNNRKLQVCDDSAL 174
LG + H + + K HCV ++Y WG+N + Q+ D +
Sbjct: 4325 RLGHGSVDHVRRPKKVAALQGKKIISIATGSLHCVACSDSGEVYTWGDNDEGQL-GDGTV 4383
Query: 175 KIIEEPKVI 183
I+ P+++
Sbjct: 4384 TAIQRPRLV 4392
Score = 50.4 bits (119), Expect = 4e-06
Identities = 81/320 (25%), Positives = 118/320 (36%), Gaps = 70/320 (21%)
Query: 10 GSNGNGQLGVGHDEDLMLP-QLSFQSDGVGIKKVSC--GGNHSLLLLEDGSLYWCGDNSS 66
G NG+LG+G ++ LP QL V +KKV+ GG H+L L DG ++ G+
Sbjct: 3044 GEGTNGRLGLGVTHNVPLPHQLPVLRQYV-VKKVAVHSGGKHALALTLDGKVFSWGEGED 3102
Query: 67 GQCASSDI----KISLEWIPIPGKFLDIACGWEVTIVIDEDGWVKTRGRGDKGELGVPRL 122
G+ + K L K D+ACG + I G + T G G+ G LG
Sbjct: 3103 GKLGHGNRTTLDKPRLVEALRAKKIRDVACGSSHSAAISSQGELYTWGLGEYGRLG---- 3158
Query: 123 KHSTEWIDLFRCEDPKGSRCYATFQHCVVVVPEKIYGWGNNRKLQVC----DDSALKIIE 178
H L P+ + R +QV D L + E
Sbjct: 3159 -HGDNTTQL---------------------KPKLVTALAGRRVVQVACGSRDAQTLALTE 3196
Query: 179 EPKVIYEGDTSDIEMALGKDFTCVLSRTENKLIIKGSLAKELPELISQLSHDFGSIAKID 238
+ V GD DF KL GS + P I +LS + +I+
Sbjct: 3197 DGAVFSWGDG---------DF--------GKLGRGGSEGSDTPHEIERLSGI--GVVQIE 3237
Query: 239 SMWSSLHILTGERKLISIGRGS-----HG--QFLEEPLP------SETLDFVTGSEHGVV 285
LT ++ + G+G HG Q + +P P + G+ H +
Sbjct: 3238 CGAQFSLALTRAGEVWTWGKGDYYRLGHGGDQHVRKPQPIGGLRGRRVIHVAVGALHCLA 3297
Query: 286 TTADMKVYCWGWGEHGNCGS 305
T +VY WG +HG GS
Sbjct: 3298 VTDAGQVYAWGDNDHGQQGS 3317
Score = 50.1 bits (118), Expect = 5e-06
Identities = 36/120 (30%), Positives = 56/120 (46%), Gaps = 6/120 (5%)
Query: 5 ELLCFGSNGNGQLGVGHDEDLMLPQLSFQSDGVGIKKVSCGGNHSLLLLEDGSLYWCGDN 64
++ +G +G+LG G+ L P+L I+ V+CG +HS + G LY G
Sbjct: 3093 KVFSWGEGEDGKLGHGNRTTLDKPRLVEALRAKKIRDVACGSSHSAAISSQGELYTWGLG 3152
Query: 65 SSGQCASSD----IKISLEWIPIPGKFLDIACGWE--VTIVIDEDGWVKTRGRGDKGELG 118
G+ D +K L + + +ACG T+ + EDG V + G GD G+LG
Sbjct: 3153 EYGRLGHGDNTTQLKPKLVTALAGRRVVQVACGSRDAQTLALTEDGAVFSWGDGDFGKLG 3212
>Hs13540582 [S] KOG1426 FOG: RCC1 domain
Length = 464
Score = 54.3 bits (129), Expect = 3e-07
Identities = 40/186 (21%), Positives = 78/186 (41%), Gaps = 10/186 (5%)
Query: 39 IKKVSCGGNHSLLLLEDGSLYWCGDNSSGQCASSDIKISL--------EWIPIPGKFLDI 90
+ +VSCG HSL+L + ++ G+NS GQC ++ + G+ + +
Sbjct: 176 VLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQV 235
Query: 91 ACGWEVTIVIDEDGWVKTRGRGDKGELGVPRLKHSTEWIDLFRCEDPKGSRCYATFQHCV 150
ACG + ++ + + G V + G G G+ G+ ++ L AT+ C
Sbjct: 236 ACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCC 295
Query: 151 VVVPEK--IYGWGNNRKLQVCDDSALKIIEEPKVIYEGDTSDIEMALGKDFTCVLSRTEN 208
+ V ++GWGN+ LQ+ + + P+ ++ + A C + E
Sbjct: 296 LAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEG 355
Query: 209 KLIIKG 214
+ + G
Sbjct: 356 HVFVWG 361
>At3g55580 [S] KOG1426 FOG: RCC1 domain
Length = 488
Score = 53.9 bits (128), Expect = 3e-07
Identities = 32/103 (31%), Positives = 56/103 (54%), Gaps = 5/103 (4%)
Query: 5 ELLCFGSNGNGQLGVGHDEDLMLPQL--SFQSDGVGIKKVSCGGNHSLLLLEDGSLYWCG 62
++ FG N GQLG G D+ LP+L + + V +K +SCG H+ ++ ++G ++ G
Sbjct: 383 DVYAFGGNQFGQLGTGCDQAETLPKLLEAPNLENVNVKTISCGARHTAVITDEGRVFCWG 442
Query: 63 DNSSGQCASSDI--KISLEWIPIPGKF-LDIACGWEVTIVIDE 102
N GQ D+ + + + I F +IACGW T+++ +
Sbjct: 443 WNKYGQLGIGDVIDRNAPAEVRIKDCFPKNIACGWWHTLLLGQ 485
>At5g60870 [S] KOG1426 FOG: RCC1 domain
Length = 423
Score = 52.4 bits (124), Expect = 1e-06
Identities = 49/184 (26%), Positives = 83/184 (44%), Gaps = 25/184 (13%)
Query: 3 SYELLCFG-SNGNGQLGVGHDED------LMLPQLSFQSDGVGIKKVSCGGNHSLLLLED 55
S EL +G G+G+LG+G L +P ++ V + VSCGG ++ L ++
Sbjct: 200 SGELYMWGREEGDGRLGLGPGRGPNEGGGLSVPS-KVKALTVPVASVSCGGFFTMALTKE 258
Query: 56 GSLYWCGDNSSGQCASSDIKISLEWIPIPG----KFLDIACGWEVTIVIDEDGWVKTRGR 111
G L+ G NS+ + D E +P+P + IACG ++ + E+G V + G
Sbjct: 259 GQLWNWGANSNYELGRGDNLGGWEPMPVPSLEGVRITQIACGGYHSLALTEEGKVLSWGH 318
Query: 112 GDKGELGVPRLKHSTEWIDLFRCEDPK-------GSRCYATFQHCVVVVPEKIYGWGNNR 164
G G+LG L++ ++ D K GS A + +++ WGN +
Sbjct: 319 GGHGQLGSSSLRNQKVPTEIEALADKKIVFIASGGSSSAA------ITDGGELWMWGNAK 372
Query: 165 KLQV 168
Q+
Sbjct: 373 DFQL 376
Score = 52.0 bits (123), Expect = 1e-06
Identities = 41/126 (32%), Positives = 62/126 (48%), Gaps = 12/126 (9%)
Query: 5 ELLCFGSNGNGQLGVGHD----EDLMLPQLSFQSDGVGIKKVSCGGNHSLLLLEDGSLYW 60
+L +G+N N +LG G + E + +P L +GV I +++CGG HSL L E+G +
Sbjct: 260 QLWNWGANSNYELGRGDNLGGWEPMPVPSL----EGVRITQIACGGYHSLALTEEGKVLS 315
Query: 61 CGDNSSGQCASSDI---KISLEWIPIPG-KFLDIACGWEVTIVIDEDGWVKTRGRGDKGE 116
G GQ SS + K+ E + K + IA G + I + G + G +
Sbjct: 316 WGHGGHGQLGSSSLRNQKVPTEIEALADKKIVFIASGGSSSAAITDGGELWMWGNAKDFQ 375
Query: 117 LGVPRL 122
LGVP L
Sbjct: 376 LGVPGL 381
>7293028 [T] KOG1428 Inhibitor of type V adenylyl cyclases/Neuronal
presynaptic protein Highwire/PAM/RPM-1
Length = 2857
Score = 51.2 bits (121), Expect = 2e-06
Identities = 29/95 (30%), Positives = 48/95 (50%), Gaps = 2/95 (2%)
Query: 26 MLPQLSFQSDGVGIKKVSCGGNHSLLLLEDGSLYWCGDNSSGQCASSDIK--ISLEWIPI 83
+ PQL + + +V+CG +H+++L G +Y G N GQ S D++ + +
Sbjct: 1045 LAPQLLQLTSSSPVVQVACGLHHTVVLTLAGEVYTFGSNQYGQLGSGDLQPVSGPVRVQV 1104
Query: 84 PGKFLDIACGWEVTIVIDEDGWVKTRGRGDKGELG 118
PG +A G T+++ G V T G KG+LG
Sbjct: 1105 PGAISQVAAGSNHTVLLTSKGMVYTFGNYQKGQLG 1139
>Hs19923519 [S] KOG1426 FOG: RCC1 domain
Length = 531
Score = 50.8 bits (120), Expect = 3e-06
Identities = 46/168 (27%), Positives = 71/168 (41%), Gaps = 10/168 (5%)
Query: 5 ELLCFGSNGNGQLGVGHDEDLMLPQLSFQSDGVGIKKVSCG-GNHSLLLLEDGSLYWCGD 63
E+ FG N + LG G ++ ++P+ G IK +S G G H LL EDG +Y G
Sbjct: 42 EVFVFGLNYSNCLGTGDNQSTLVPKKLEGLCGKKIKSLSYGSGPHVLLSTEDGVVYAWGH 101
Query: 64 NSSGQCASSDIKISLEWIPIPGKFL-----DIACGWEVTIVIDEDGWVKTRGRGDKGELG 118
N Q + + + + L ++ACG ++ + DG V G + G++G
Sbjct: 102 NGYSQLGNGTTNQGIAPVQVCTNLLIKQVVEVACGSHHSMALAADGEVFAWGYNNCGQVG 161
Query: 119 VPRLKHSTEWIDLFRCEDPK---GSRCYATFQHCVVVVPEKIYGWGNN 163
+ + C K G C T V+ E +YGWG N
Sbjct: 162 SGSTANQPTPRKVTNCLHIKRVVGIACGQTSSMAVLDNGE-VYGWGYN 208
>YGL097w [S] KOG1426 FOG: RCC1 domain
Length = 482
Score = 49.3 bits (116), Expect = 8e-06
Identities = 39/143 (27%), Positives = 66/143 (45%), Gaps = 20/143 (13%)
Query: 5 ELLCFGSNGNGQLGVGHD-EDLML---PQLSFQSDGVGIKKVSCGGNHSLLLLEDGSLYW 60
+L+ +G N GQ GV D ED L P+ D V I+ ++ G +HSL+L +DG LY
Sbjct: 294 KLVSWGLNQFGQCGVSEDVEDGALVTKPKRLALPDNVVIRSIAAGEHHSLILSQDGDLYS 353
Query: 61 CG----------DNSSGQCASSDIKISLEWIPIP------GKFLDIACGWEVTIVIDEDG 104
CG ++ + D+ +P+P KF +A G ++ + ++G
Sbjct: 354 CGRLDMFEVGIPKDNLPEYTYKDVHGKARAVPLPTKLNNVPKFKSVAAGSHHSVAVAQNG 413
Query: 105 WVKTRGRGDKGELGVPRLKHSTE 127
+ G G+ +G+ + TE
Sbjct: 414 IAYSWGFGETYAVGLGPFEDDTE 436
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.318 0.139 0.437
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,395,214
Number of Sequences: 60738
Number of extensions: 1088394
Number of successful extensions: 2767
Number of sequences better than 1.0e-05: 27
Number of HSP's better than 0.0 without gapping: 5
Number of HSP's successfully gapped in prelim test: 22
Number of HSP's that attempted gapping in prelim test: 2436
Number of HSP's gapped (non-prelim): 201
length of query: 349
length of database: 30,389,216
effective HSP length: 107
effective length of query: 242
effective length of database: 23,890,250
effective search space: 5781440500
effective search space used: 5781440500
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)