ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactVI4399 normal U KOG2273 Intracellular trafficking, secretion, and vesicular transport Membrane coat complex Retromer, subunit VPS5/SNX1, Sorting nexins, and related PX domain-containing proteins
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactVI4399 1533628 1535622 665
(665 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YOR069w [U] KOG2273 Membrane coat complex Retromer subunit VPS5/... 327 4e-89
SPCPJ732.01 [U] KOG2273 Membrane coat complex Retromer subunit V... 186 1e-46
YKR078w [U] KOG2273 Membrane coat complex Retromer subunit VPS5/... 157 4e-38
Hs4507139 [U] KOG2273 Membrane coat complex Retromer subunit VPS... 143 1e-33
Hs14755196 [U] KOG2273 Membrane coat complex Retromer subunit VP... 143 1e-33
Hs4507141 [U] KOG2273 Membrane coat complex Retromer subunit VPS... 136 1e-31
Hs14725602 [U] KOG2273 Membrane coat complex Retromer subunit VP... 135 2e-31
7295807 [U] KOG2273 Membrane coat complex Retromer subunit VPS5/... 116 1e-25
CE07927 [U] KOG2273 Membrane coat complex Retromer subunit VPS5/... 93 1e-18
At5g06140 [U] KOG2273 Membrane coat complex Retromer subunit VPS... 85 3e-16
At5g58440 [U] KOG2273 Membrane coat complex Retromer subunit VPS... 80 1e-14
At5g07120 [U] KOG2273 Membrane coat complex Retromer subunit VPS... 79 3e-14
Hs7706715 [U] KOG2273 Membrane coat complex Retromer subunit VPS... 77 1e-13
Hs22056379 [U] KOG2528 Sorting nexin SNX9/SH3PX1 and related pro... 67 1e-10
Hs22045020 [U] KOG2273 Membrane coat complex Retromer subunit VP... 66 1e-10
Hs16418371 [U] KOG2528 Sorting nexin SNX9/SH3PX1 and related pro... 65 3e-10
YJL036w [U] KOG2273 Membrane coat complex Retromer subunit VPS5/... 62 3e-09
SPAC6F6.12 [U] KOG2273 Membrane coat complex Retromer subunit VP... 61 5e-09
Hs7019539 [U] KOG2527 Sorting nexin SNX11 61 5e-09
CE19073 [U] KOG2528 Sorting nexin SNX9/SH3PX1 and related proteins 59 2e-08
CE16547 [U] KOG2527 Sorting nexin SNX11 58 5e-08
7294889 [U] KOG2528 Sorting nexin SNX9/SH3PX1 and related proteins 57 1e-07
Hs7019541 [U] KOG2527 Sorting nexin SNX11 56 2e-07
SPBC1711.11 [U] KOG2273 Membrane coat complex Retromer subunit V... 55 4e-07
Hs4507143 [U] KOG2527 Sorting nexin SNX11 53 1e-06
7299654 [U] KOG2527 Sorting nexin SNX11 52 2e-06
Hs7706706 [U] KOG2528 Sorting nexin SNX9/SH3PX1 and related prot... 52 3e-06
SPBC887.06c [U] KOG2527 Sorting nexin SNX11 51 6e-06
Hs22065944 [U] KOG2273 Membrane coat complex Retromer subunit VP... 51 6e-06
>YOR069w [U] KOG2273 Membrane coat complex Retromer subunit VPS5/SNX1
Sorting nexins and related PX domain-containing proteins
Length = 312
Score = 327 bits (838), Expect = 4e-89
Identities = 159/313 (50%), Positives = 227/313 (71%), Gaps = 1/313 (0%)
Query: 353 MERMLQHIASNHVLQKDEDFILFLTSEKWSQESKVREQISGSKASHDSNDISDIHISELK 412
ME ML+ I + VLQKD+DF+LFLTS+ +S ESK R ++GS A +DSND+S++ ISE++
Sbjct: 1 MESMLKKICQDPVLQKDKDFLLFLTSDDFSSESKKRAFLTGSGAINDSNDLSEVRISEIQ 60
Query: 413 LLGSEDAERVLKNGGLDTETGGSFMGLSFATAPKYKEPDQFFVDAAEKMDILEEQLKQLY 472
LLG+EDA VLKNGG+D E+ FM +SF++ PKY E D+FF++ +K+D LE+ LK+L
Sbjct: 61 LLGAEDAAEVLKNGGIDAESHKGFMSISFSSLPKYNEADEFFIEKKQKIDELEDNLKKLS 120
Query: 473 KALELVDSQRSDLCSVINEFSETLKALADLELSNRTSDLLQNFAEVHLRIKESTSRSSMQ 532
K+LE+VD+ R+ L + EFS ++ LA L +S S+LL NFA+VH IK S RSS+Q
Sbjct: 121 KSLEMVDTSRNTLAASTEEFSSMVETLASLNVSEPNSELLNNFADVHKSIKSSLERSSLQ 180
Query: 533 DSLTLGITIDDNLRAIGSVKAVLNQRKKLGYYILLVENDLNKKQTQFNKVSGNSANSEKA 592
++LT+G+ +DD +R++ SVKA+ NQR KLGY+++++END+NKK +Q K+ G + +SEK
Sbjct: 181 ETLTMGVMLDDYIRSLASVKAIFNQRSKLGYFLVVIENDMNKKHSQLGKL-GQNIHSEKF 239
Query: 593 TSIENELRILTSRCNKIKQEWQTIAEVIRKDVNQHDVDTIEDFRNNMEIYLESAIESQKE 652
+ E + L R N K++WQ + + I+ + D I +FRN MEI LE+AIESQKE
Sbjct: 240 REMRKEFQTLERRYNLTKKQWQAVGDKIKDEFQGFSTDKIREFRNGMEISLEAAIESQKE 299
Query: 653 CIEIWETFYQNNL 665
CIE+WETFYQ NL
Sbjct: 300 CIELWETFYQTNL 312
>SPCPJ732.01 [U] KOG2273 Membrane coat complex Retromer subunit VPS5/SNX1
Sorting nexins and related PX domain-containing proteins
Length = 576
Score = 186 bits (471), Expect = 1e-46
Identities = 121/400 (30%), Positives = 201/400 (50%), Gaps = 27/400 (6%)
Query: 265 ETIEKFQISVVDPMKIGDITSVYVEYTV---ISKSNLLEGKPTRVKRRYRDFRWLYRQLQ 321
+++ F I V DP + +IT + Y+V + + N V+RRY DF +LY+ L
Sbjct: 197 QSLTPFYIQVHDPHTVKEITKSHTVYSVSTRLEEHNQPSVSNVTVQRRYNDFAFLYQLLS 256
Query: 322 HNHWGKIIPPPPEKQAVGRFKQDFIENRRAQMERMLQHIASNHVLQKDEDFILFLTSEKW 381
+NH G IIPP PEKQ VGRF +FIE RRA +E ML+ I+++ VL+ D F LFL +E +
Sbjct: 257 NNHPGCIIPPIPEKQVVGRFDDEFIEQRRAALEVMLRKISAHPVLRDDYSFKLFLEAETF 316
Query: 382 SQESKVREQISGSKASHDSNDISDIHISELKLLGSEDAERVLKNGGLDTETGGSFMGLSF 441
R + S +S L +L + T GS
Sbjct: 317 DPRMTHRTTLIESSSS--------------PLRSGPSTSGLLDSFTSAFHTSGS------ 356
Query: 442 ATAPKYKEPDQFFVDAAEKMDILEEQLKQLYKALELVDSQRSDLCSVINEFSETLKALAD 501
K+ E D ++A + +D LE QLK +Y AL L QR S I++F E + L+
Sbjct: 357 ---SKFSEQDPILIEAKDTLDSLETQLKSVYHALLLSIDQRIQFASAIHDFGEAVGNLSL 413
Query: 502 LELSNRTSDLLQNFAEVHLRIKESTSRSSMQDSLTLGITIDDNLRAIGSVKAVLNQRKKL 561
++L S +++ + ++ R QD+LTLG T+++ +R + S K R+KL
Sbjct: 414 VDLEPTLSSKFDGLSQLQVELRFVQERKVAQDNLTLGTTLEEYIRYVESAKNAFTTRQKL 473
Query: 562 GYYILLVENDLNKKQTQFNKVSGNSANSEKATS-IENELRILTSRCNKIKQEWQTIAEVI 620
+++ +TQ K + + +K+ +E + ++ +++E+ ++
Sbjct: 474 WQTWQSSVQAVSRAKTQLEKCKKQAKSQQKSLPYLEEQYEKYRAKAADLEKEFSESTTLL 533
Query: 621 RKDVNQHDVDTIEDFRNNMEIYLESAIESQKECIEIWETF 660
++D++ ++D + ++E +LESAIESQKE IE WE+F
Sbjct: 534 KRDLSSLTTSRVDDLKASVETWLESAIESQKEIIERWESF 573
>YKR078w [U] KOG2273 Membrane coat complex Retromer subunit VPS5/SNX1
Sorting nexins and related PX domain-containing proteins
Length = 585
Score = 157 bits (398), Expect = 4e-38
Identities = 143/577 (24%), Positives = 261/577 (44%), Gaps = 108/577 (18%)
Query: 188 KPTQEKASISIHDPLVE---SLVEKEKNEQFVEESLADDKDEGKLSLEREMDSPLY---- 240
K + SI +++ +V+ S+ + E++ + V S++DD+D K ++ M +P
Sbjct: 5 KASHASPSIGVNEFVVQGEISIDDSERSVKSVSVSISDDEDS-KTDVQDNMATPSTRSKF 63
Query: 241 ---LIAERKVPSYIPKTNSTMSSSNTQETIEKF------------------QISVVDPMK 279
L + ++ PK + + E QI + +
Sbjct: 64 QTDLAIDNRLLEKDPKYKKLFTEKRRRRRPESCINLMTKGKGTGQKDNINDQIFSLRILP 123
Query: 280 IGDITSVYVEYTVISKSNLLEGKPTRVKRRYRDFRWLYRQLQHNHWGKIIPPPPEK---- 335
D+ S+ +I S + + T + R + DF WLY QLQ+NHWGK IPPP
Sbjct: 124 GSDLNSLKDSLWIIKISTQPDVEKT-IARAFSDFYWLYHQLQNNHWGKTIPPPTRSNILV 182
Query: 336 -------------------QAVGRFKQDFIENRRAQMERMLQHIASNHVLQKDEDFILFL 376
+ FK ++I + Q+ M++HI ++ VL+ D +FI F+
Sbjct: 183 EKDEFAINHLFMIRNNEKYDPIFNFKPEYIIS--LQLMAMIKHIFNDKVLRLDSNFIDFI 240
Query: 377 T--------------------------------SEKWSQESKVREQISGSKAS-HDSNDI 403
+ +++ ++SK E I+ S AS ++
Sbjct: 241 SWDDDLPESLQIVVDDSTFTGDKILMTSSQFRELKEFHKQSKKVESITNSHASLIPVTEL 300
Query: 404 SDIHISELKLLGSEDAERVLKNGGLDTETGGS--------------FMGLSF-ATAPKYK 448
++I+IS KL +D +R+ + D + F LSF ++AP Y+
Sbjct: 301 TEIYISPTKLFSRKDYQRLFQPQSTDNTFNNNDPLIQEWIPKSKTLFTSLSFGSSAPTYQ 360
Query: 449 EPDQFFVDAAEKMDILEEQLKQ-LYKALELVDSQRSDLCSVINEFSETLKALADLELSNR 507
E + + I +EQ KQ LY L+ + + + SVINEF+E LK ++ E+
Sbjct: 361 EASTEIQACHDWVSISKEQWKQLLYHVLQYIVDEAVKVNSVINEFTECLKQISLDEVIRA 420
Query: 508 TSDLLQNFAEVHLRIKESTSRSSMQDSLTLGITIDDNLRAIGSVKAVLNQRKKLGYYILL 567
S+L F++++ + +S QD L L I D+N+R S +++LNQR KLG + +
Sbjct: 421 NSELFLKFSKLNESFLKKFKGASRQDILKLIILFDENVRFCESFESILNQRLKLGKILSI 480
Query: 568 VENDLNKKQTQFNKVS--GNSANSE--KATSIENELRILTSRCNKIKQEWQTIAEVIRKD 623
+E DL+KK+ +K+S N++N+E K + E+E RI+ R N++KQ W+ I E I +
Sbjct: 481 IEVDLDKKKNFLDKLSPGNNNSNNEDLKIRTAEDEYRIVLKRYNRVKQSWEKIMEDILNE 540
Query: 624 VNQHDVDTIEDFRNNMEIYLESAIESQKECIEIWETF 660
+ + + + ++ + ++ +K +++W+ F
Sbjct: 541 RKEFEKREAAEVNSCLKSIRDLNMDEKKHYLQLWQDF 577
>Hs4507139 [U] KOG2273 Membrane coat complex Retromer subunit VPS5/SNX1
Sorting nexins and related PX domain-containing proteins
Length = 522
Score = 143 bits (360), Expect = 1e-33
Identities = 120/476 (25%), Positives = 226/476 (47%), Gaps = 65/476 (13%)
Query: 210 EKNEQFVEESLADDKDEGKLSLEREMDSPLYLIAERKVPSYIPKTNSTMSSSNTQETIEK 269
E+ +Q ++ AD E LSL+ ++ ++A+ + +P +T +SS Q T E+
Sbjct: 79 EEQDQEPQDLFADATVE--LSLDSTQNNQKKVLAKTLI--XLPPQEAT-NSSKPQPTYEE 133
Query: 270 FQ-----------ISVVDPMKIGDITSVYVEYTVISKSNL--LEGKPTRVKRRYRDFRWL 316
+ + + DP KIGD + YV Y V ++++L K VKRR+ DF L
Sbjct: 134 LEEEEQEDQFDLTVGITDPEKIGDGMNAYVAYKVTTQTSLPLFRSKQFAVKRRFSDFLGL 193
Query: 317 YRQL--QHNHWGKIIPPPPEKQAVGRFK----------QDFIENRRAQMERMLQHIASNH 364
Y +L +H+ G I+PPPPEK +G K +F+E RRA +ER LQ I ++
Sbjct: 194 YEKLSEKHSQNGFIVPPPPEKSLIGMTKVKVGKEDSSSAEFLEKRRAALERYLQRIVNHP 253
Query: 365 VLQKDEDFILFLTSEKWSQESKVREQISGSKASHDSNDISDIHISELKLLGSEDAERVLK 424
+ +D D FL E+ + + + +SG+ N +D +S++ +
Sbjct: 254 TMLQDPDVREFLEKEELPR-AVGTQTLSGAGLLKMFNKATDA-VSKMTI----------- 300
Query: 425 NGGLDTETGGSFMGLSFATAPKYKEPDQFFVDAAEKMDILEEQLKQLYKALELVDSQRSD 484
K E D +F + ++++ E++L++L+ +E + + R +
Sbjct: 301 ---------------------KMNESDIWFEEKLQEVECEEQRLRKLHAVVETLVNHRKE 339
Query: 485 LCSVINEFSETLKALADLELSNRTSDLLQNFAEVHLRIKESTSRSSMQDSLTLGITIDDN 544
L +F+++L L E + S L AEV +I++ + D L + D
Sbjct: 340 LALNTAQFAKSLAMLGSSEDNTALSRALSQLAEVEEKIEQLHQEQANNDFFLLAELLSDY 399
Query: 545 LRAIGSVKAVLNQRKKLGYYILLVENDLNKKQTQFNKVSGNSANSEKATSIENELRILTS 604
+R + V+A +QR K + L KK+ ++ + +K ++E+ S
Sbjct: 400 IRLLAIVRAAFDQRMKTWQRWQDAQATLQKKREAEARLLW-ANKPDKLQQAKDEILEWES 458
Query: 605 RCNKIKQEWQTIAEVIRKDVNQHDVDTIEDFRNNMEIYLESAIESQKECIEIWETF 660
R + +++++ I+ V+RK+V + + + +DF+N++ YLE+ + SQ++ + WE F
Sbjct: 459 RVTQYERDFERISTVVRKEVIRFEKEKSKDFKNHVIKYLETLLYSQQQLAKYWEAF 514
>Hs14755196 [U] KOG2273 Membrane coat complex Retromer subunit VPS5/SNX1
Sorting nexins and related PX domain-containing proteins
Length = 522
Score = 143 bits (360), Expect = 1e-33
Identities = 120/476 (25%), Positives = 226/476 (47%), Gaps = 65/476 (13%)
Query: 210 EKNEQFVEESLADDKDEGKLSLEREMDSPLYLIAERKVPSYIPKTNSTMSSSNTQETIEK 269
E+ +Q ++ AD E LSL+ ++ ++A+ + +P +T +SS Q T E+
Sbjct: 79 EEQDQEPQDLFADATVE--LSLDSTQNNQKKVLAKTLIS--LPPQEAT-NSSKPQPTYEE 133
Query: 270 FQ-----------ISVVDPMKIGDITSVYVEYTVISKSNL--LEGKPTRVKRRYRDFRWL 316
+ + + DP KIGD + YV Y V ++++L K VKRR+ DF L
Sbjct: 134 LEEEEQEDQFDLTVGITDPEKIGDGMNAYVAYKVTTQTSLPLFRSKQFAVKRRFSDFLGL 193
Query: 317 YRQL--QHNHWGKIIPPPPEKQAVGRFK----------QDFIENRRAQMERMLQHIASNH 364
Y +L +H+ G I+PPPPEK +G K +F+E RRA +ER LQ I ++
Sbjct: 194 YEKLSEKHSQNGFIVPPPPEKSLIGMTKVKVGKEDSSSAEFLEKRRAALERYLQRIVNHP 253
Query: 365 VLQKDEDFILFLTSEKWSQESKVREQISGSKASHDSNDISDIHISELKLLGSEDAERVLK 424
+ +D D FL E+ + + + +SG+ N +D +S++ +
Sbjct: 254 TMLQDPDVREFLEKEELPR-AVGTQTLSGAGLLKMFNKATDA-VSKMTI----------- 300
Query: 425 NGGLDTETGGSFMGLSFATAPKYKEPDQFFVDAAEKMDILEEQLKQLYKALELVDSQRSD 484
K E D +F + ++++ E++L++L+ +E + + R +
Sbjct: 301 ---------------------KMNESDIWFEEKLQEVECEEQRLRKLHAVVETLVNHRKE 339
Query: 485 LCSVINEFSETLKALADLELSNRTSDLLQNFAEVHLRIKESTSRSSMQDSLTLGITIDDN 544
L +F+++L L E + S L AEV +I++ + D L + D
Sbjct: 340 LALNTAQFAKSLAMLGSSEDNTALSRALSQLAEVEEKIEQLHQEQANNDFFLLAELLSDY 399
Query: 545 LRAIGSVKAVLNQRKKLGYYILLVENDLNKKQTQFNKVSGNSANSEKATSIENELRILTS 604
+R + V+A +QR K + L KK+ ++ + +K ++E+ S
Sbjct: 400 IRLLAIVRAAFDQRMKTWQRWQDAQATLQKKREAEARLLW-ANKPDKLQQAKDEILEWES 458
Query: 605 RCNKIKQEWQTIAEVIRKDVNQHDVDTIEDFRNNMEIYLESAIESQKECIEIWETF 660
R + +++++ I+ V+RK+V + + + +DF+N++ YLE+ + SQ++ + WE F
Sbjct: 459 RVTQYERDFERISTVVRKEVIRFEKEKSKDFKNHVIKYLETLLYSQQQLAKYWEAF 514
>Hs4507141 [U] KOG2273 Membrane coat complex Retromer subunit VPS5/SNX1
Sorting nexins and related PX domain-containing proteins
Length = 519
Score = 136 bits (342), Expect = 1e-31
Identities = 128/531 (24%), Positives = 232/531 (43%), Gaps = 92/531 (17%)
Query: 176 LFSSARTRRHPIKPTQEKASISIHDPLVESLVEKEKNEQFVEESLADDKDE--GKLSLER 233
LF+S + + E AS+ D S K E L DD+++ + + E
Sbjct: 27 LFTSTVSTLESSPSSPEPASLPAEDISANSNGPKP-----TEVVLDDDREDLFAEATEEV 81
Query: 234 EMDSPLY--LIAERKVPSYIPKTNSTMSS--------------SNTQETIEK-------- 269
+DSP +++ P+ P T +T+ + ++E IE+
Sbjct: 82 SLDSPEREPILSSEPSPAVTPVTPTTLIAPRIESKSMSAPVIFDRSREEIEEEANGDIFD 141
Query: 270 FQISVVDPMKIGDITSVYVEYTVISKSNL--LEGKPTRVKRRYRDFRWLYRQL--QHNHW 325
+I V DP K+GD + Y+ Y V +K++L VKRR+ DF L+ +L ++ H
Sbjct: 142 IEIGVSDPEKVGDGMNAYMAYRVTTKTSLSMFSKSEFSVKRRFSDFLGLHSKLASKYLHV 201
Query: 326 GKIIPPPPEKQAVGRFK----------QDFIENRRAQMERMLQHIASNHVLQKDEDFILF 375
G I+PP PEK VG K +F+E RRA +ER LQ + L +D D F
Sbjct: 202 GYIVPPAPEKSIVGMTKVKVGKEDSSSTEFVEKRRAALERYLQRTVKHPTLLQDPDLRQF 261
Query: 376 LTSEKWSQESKVREQISGSKASHDSNDISDIHISELKLLGSEDAERVLKNGGLDTETGGS 435
L S + + + +SG+ N +D ++++ +
Sbjct: 262 LESSELPRAVNT-QALSGAGILRMVNKAADA-VNKMTI---------------------- 297
Query: 436 FMGLSFATAPKYKEPDQFFVDAAEKMDILEEQLKQLYKALELVDSQRSDLCSVINEFSET 495
K E D +F + ++ + L++QL++L+ ++E + R +L + F+++
Sbjct: 298 ----------KMNESDAWFEEKQQQFENLDQQLRKLHVSVEALFCHRKELSANTAAFAKS 347
Query: 496 LKALADLELSNRTSDLLQNFAEVHLRIKESTSRSSMQDSLTLGITIDDNLRAIGSVKAVL 555
L + E S L AEV +I + + D + D +R I +VK V
Sbjct: 348 AAMLGNSEDHTALSRALSQLAEVEEKIDQLHQEQAFSDFYMFSELLSDYIRLIAAVKGVF 407
Query: 556 NQRKKL------GYYILLVENDLNKKQTQFNKVSGNSANSEKATSIENELRILTSRCNKI 609
+ R K LL + + K NK +K +NE+R ++ +
Sbjct: 408 DHRMKCWQKWEDAQITLLKKREAEAKMMVANK-------PDKIQQAKNEIREWEAKVQQG 460
Query: 610 KQEWQTIAEVIRKDVNQHDVDTIEDFRNNMEIYLESAIESQKECIEIWETF 660
+++++ I++ IRK+V + + + ++DF+ + YLES +++Q++ I+ WE F
Sbjct: 461 ERDFEQISKTIRKEVGRFEKERVKDFKTVIIKYLESLVQTQQQLIKYWEAF 511
>Hs14725602 [U] KOG2273 Membrane coat complex Retromer subunit VPS5/SNX1
Sorting nexins and related PX domain-containing proteins
Length = 519
Score = 135 bits (341), Expect = 2e-31
Identities = 128/531 (24%), Positives = 232/531 (43%), Gaps = 92/531 (17%)
Query: 176 LFSSARTRRHPIKPTQEKASISIHDPLVESLVEKEKNEQFVEESLADDKDE--GKLSLER 233
LF+S + + E AS+ D S K E L DD+++ + + E
Sbjct: 27 LFTSTVSTLESSPSSPEPASLPAEDISANSNGPKP-----TEVVLDDDREDLFAEATEEV 81
Query: 234 EMDSPLY--LIAERKVPSYIPKTNSTMSS--------------SNTQETIEK-------- 269
+DSP +++ P+ P T +T+ + ++E IE+
Sbjct: 82 SLDSPEREPILSSEPSPAVTPVTPTTLIAPRIESKSMSAPVIFDRSREEIEEEANGDIFD 141
Query: 270 FQISVVDPMKIGDITSVYVEYTVISKSNL--LEGKPTRVKRRYRDFRWLYRQL--QHNHW 325
+I V DP K+GD + Y+ Y V +K++L VKRR+ DF L+ +L ++ H
Sbjct: 142 IEIGVSDPEKVGDGMNAYMAYRVTTKTSLSMFSKSEFSVKRRFSDFLGLHSKLASKYLHV 201
Query: 326 GKIIPPPPEKQAVGRFK----------QDFIENRRAQMERMLQHIASNHVLQKDEDFILF 375
G I+PP PEK VG K +F+E RRA +ER LQ + L +D D F
Sbjct: 202 GYIVPPAPEKSIVGMTKVKVGKEDSSSTEFVEKRRAALERYLQRTVKHPTLLQDPDLRQF 261
Query: 376 LTSEKWSQESKVREQISGSKASHDSNDISDIHISELKLLGSEDAERVLKNGGLDTETGGS 435
L S + + + +SG+ N +D ++++ +
Sbjct: 262 LESSELPRAVNT-QALSGAGILRMVNKAADA-VNKMTI---------------------- 297
Query: 436 FMGLSFATAPKYKEPDQFFVDAAEKMDILEEQLKQLYKALELVDSQRSDLCSVINEFSET 495
K E D +F + ++ + L++QL++L+ ++E + R +L + F+++
Sbjct: 298 ----------KMNESDAWFEEKQQQFENLDQQLRKLHVSVEALVCHRKELSANTAAFAKS 347
Query: 496 LKALADLELSNRTSDLLQNFAEVHLRIKESTSRSSMQDSLTLGITIDDNLRAIGSVKAVL 555
L + E S L AEV +I + + D + D +R I +VK V
Sbjct: 348 AAMLGNSEDHTALSRALSQLAEVEEKIDQLHQEQAFADFYMFSELLSDYIRLIAAVKGVF 407
Query: 556 NQRKKL------GYYILLVENDLNKKQTQFNKVSGNSANSEKATSIENELRILTSRCNKI 609
+ R K LL + + K NK +K +NE+R ++ +
Sbjct: 408 DHRMKCWQKWEDAQITLLKKREAEAKMMVANK-------PDKIQQAKNEIREWEAKVQQG 460
Query: 610 KQEWQTIAEVIRKDVNQHDVDTIEDFRNNMEIYLESAIESQKECIEIWETF 660
+++++ I++ IRK+V + + + ++DF+ + YLES +++Q++ I+ WE F
Sbjct: 461 ERDFEQISKTIRKEVGRFEKERVKDFKTVIIKYLESLVQTQQQLIKYWEAF 511
>7295807 [U] KOG2273 Membrane coat complex Retromer subunit VPS5/SNX1
Sorting nexins and related PX domain-containing proteins
Length = 458
Score = 116 bits (291), Expect = 1e-25
Identities = 108/479 (22%), Positives = 206/479 (42%), Gaps = 63/479 (13%)
Query: 210 EKNEQFVEESLADDKDEGKLSLEREMDSPLYLIAERKVPSYIPKTNSTMSSSNTQETIE- 268
E F E + + G E E+ +P + +R S S + E
Sbjct: 7 EHTRDFAEVDINNGAATGSEDEEEEVPAPGSVTLDRNESDLFVSALSPSSIGDIHPLQEV 66
Query: 269 -----KFQISVV--DPMKIGDITSVYVEYTVISKSNLLEGKPTRVK--RRYRDFRWLYRQ 319
+ IS+V DP KIGD Y+ Y V +K+N+ + K + RR+ DF ++
Sbjct: 67 LTDDGDYFISIVVSDPQKIGDGMGSYLAYKVTTKTNIPKFKRSEFSTLRRFSDFLGIHDL 126
Query: 320 L--QHNHWGKIIPPPPEKQAVGRFK---------------QDFIENRRAQMERMLQHIAS 362
L ++ G+IIPP P K +G K Q+++E RRA +ER + A
Sbjct: 127 LVGKYMRLGRIIPPAPSKNIIGSTKVKISPQQSEPGTPMTQEWVEIRRAALERFVHRTAQ 186
Query: 363 NHVLQKDEDFILFLTSEKWSQESKVREQISGSKASHDSNDISDIHISELKLLGSEDAERV 422
+ VL+ D DF+ FL S++ S +SG+ N + + ++++
Sbjct: 187 HPVLRVDLDFMNFLESDQELPRSVNTSALSGAGVIRLFNKVGET-VNKITY--------- 236
Query: 423 LKNGGLDTETGGSFMGLSFATAPKYKEPDQFFVDAAEKMDILEEQLKQLYKALELVDSQR 482
K E D +F D +++ L+ L++L+ A++ + + R
Sbjct: 237 -----------------------KMDENDPWFDDKITEVESLDANLQKLHNAMKSLVTSR 273
Query: 483 SDLCSVINEFSETLKALADLELSNRTSDLLQNFAEVHLRIKESTSRSSMQDSLTLGITID 542
+L + +++ L+ E S L N A+V +I+ S + D L I
Sbjct: 274 RELSLLTGLVAKSAAMLSTCEEHTGLSRALSNLADVEEKIELLRSEQANSDFFILAEFIK 333
Query: 543 DNLRAIGSVKAVLNQRKKLGYYILLVENDLNKKQTQFNKVSGNSAN-SEKATSIENELRI 601
D L G++K + ++R K + L+K++ N+ AN ++K + E+
Sbjct: 334 DYLGLFGAIKCIFHERVKAFQNWQYAQMQLSKRRE--NRGRFELANRADKLDQAQQEVDE 391
Query: 602 LTSRCNKIKQEWQTIAEVIRKDVNQHDVDTIEDFRNNMEIYLESAIESQKECIEIWETF 660
+ + +Q++ I+ I++++ + ++ ++DF+ N+ Y+E + Q++ + WE F
Sbjct: 392 WQGKVQRCQQQFDDISAEIKREMERFELTRVKDFKVNIIKYIEDQMAHQQQIVSYWEAF 450
>CE07927 [U] KOG2273 Membrane coat complex Retromer subunit VPS5/SNX1
Sorting nexins and related PX domain-containing proteins
Length = 472
Score = 92.8 bits (229), Expect = 1e-18
Identities = 95/461 (20%), Positives = 192/461 (41%), Gaps = 57/461 (12%)
Query: 222 DDKDEGKLSLE-----REMDSPLYLIAERKVPSYIPKTNSTMSSSNTQETIEKFQISVVD 276
+D KL L +E SP + + Y+ N S + + F++++ +
Sbjct: 38 EDTPPSKLRLHTTEEPKESSSPAVINSIEDHDQYVGNDNHYAQIS-PEPALSNFKVTMRE 96
Query: 277 PMKIGDITSVYVEYTVISKSNLLEGKPTR---VKRRYRDFRWLYRQLQHNHWGK--IIPP 331
K GD + Y+ Y + ++ + + G + RR+ DF L+ ++ + K +IP
Sbjct: 97 FEKRGDGMNAYIVYKLETEVSGVVGYTKQHYETWRRFSDFLGLHGKIVEKYLAKGIVIPQ 156
Query: 332 PPEKQAVGRFK----------QDFIENRRAQMERMLQHIASNHVLQKDEDFILFLTSEKW 381
PPEK K ++ R Q+ER + + + ++ D D FLT E
Sbjct: 157 PPEKSISALTKTKTNSDPAMSREVGIQRARQLERYICRLIQHPRMRNDCDVRDFLTIE-- 214
Query: 382 SQESKVREQISGSKASHDSNDISDIHIS-ELKLLGSEDAERVLKNGGLDTETGGSFMGLS 440
SD+ + + L S +++ KN F +
Sbjct: 215 ----------------------SDLPKAVQTAALSSFGVKKIFKN----------FQVVF 242
Query: 441 FATAPKYKEPDQFFVDAAEKMDILEEQLKQLYKALELVDSQRSDLCSVINEFSETLKALA 500
A +E D++F ++D L+E L++LY E + + R D+ + + + L LA
Sbjct: 243 SKMAFHMEEGDRWFEQVQSQVDELDEALRKLYTVTETLVASRRDMATSGEQLGKALSMLA 302
Query: 501 DLELSNRTSDLLQNFAEVHLRIKESTSRSSMQDSLTLGITIDDNLRAIGSVKAVLNQRKK 560
E S S L + +V + + + D+ +I + + I ++K V +R +
Sbjct: 303 ACEESTSLSRALSSLTDVTENVSAVYGKQAEVDNSKFSESIYEYIMLISALKDVFGERVR 362
Query: 561 LGYYILLVENDLNKKQTQFNKVS-GNSANSEKATSIENELRILTSRCNKIKQEWQTIAEV 619
+ L +K+ Q K+ +E++ ++ E+ + ++++Q + +++
Sbjct: 363 AWQQWQDAQQTLARKRDQKTKIDLSAGGRNERSDQLKGEIEDTVQKMDQLEQHFIELSKA 422
Query: 620 IRKDVNQHDVDTIEDFRNNMEIYLESAIESQKECIEIWETF 660
IR++V + D D +D + + Y+ES I + E + +WE F
Sbjct: 423 IREEVARFDADRKQDMKKMLVEYMESMIHTHTELLHLWEKF 463
>At5g06140 [U] KOG2273 Membrane coat complex Retromer subunit VPS5/SNX1
Sorting nexins and related PX domain-containing proteins
Length = 402
Score = 85.1 bits (209), Expect = 3e-16
Identities = 51/130 (39%), Positives = 73/130 (55%), Gaps = 4/130 (3%)
Query: 255 NSTMSSSNTQETIEKFQISVVDPMKIGDITSVYVEYTVISKSNLLE--GKPTRVKRRYRD 312
+ +M S + + +SV DP+K+G+ Y+ Y VI+K+NL E G V RRY D
Sbjct: 11 SGSMQSPRSPSSHPYLSVSVTDPVKLGNGVQAYISYRVITKTNLPEYQGPEKIVIRRYSD 70
Query: 313 FRWLYRQLQHNHWGKIIPPPPEKQAVG--RFKQDFIENRRAQMERMLQHIASNHVLQKDE 370
F WL +L + G IPP PEK AV RF +FIE RRA ++ + IA + LQ+ E
Sbjct: 71 FVWLRDRLFEKYKGIFIPPLPEKSAVEKFRFSAEFIEMRRAALDIFVNRIALHPELQQSE 130
Query: 371 DFILFLTSEK 380
D FL +++
Sbjct: 131 DLRTFLQADE 140
>At5g58440 [U] KOG2273 Membrane coat complex Retromer subunit VPS5/SNX1
Sorting nexins and related PX domain-containing proteins
Length = 586
Score = 79.7 bits (195), Expect = 1e-14
Identities = 109/545 (20%), Positives = 218/545 (40%), Gaps = 74/545 (13%)
Query: 168 TKSGKLNKLFSSARTRRHPIKPTQEKASISIHDPLVESLVEKEKNEQFVEESLADDK--- 224
T + S+ R P+ P + DPL+ ++ F + ++ D
Sbjct: 44 TSNSGYRSAMSTLSNVRDPLSPPPTVMIPADSDPLLAPSSYEDFRSSFSSKPISSDNSYI 103
Query: 225 ------DEGKLSLEREMDSPLYLIAERKVPSYIPKTNSTMSSSNTQETIEKFQISVVDPM 278
D + DS + + + S + S SS++ + I+ I+V +P
Sbjct: 104 EPPSYADVIFSPFDENSDSEINGTEDNSLHSQFSDSLSRSPSSSSSDYIK---ITVSNPQ 160
Query: 279 KIGDITS------VYVEYTVISKSNLLE-GKPTR--VKRRYRDFRWLYRQLQHNHWGKII 329
K +I++ Y+ Y + +++NL + G P+ V+RR+RD L +L + G I
Sbjct: 161 KEQEISNSIVGGNTYITYQITTRTNLPDFGGPSEFSVRRRFRDVVTLADRLAETYRGFCI 220
Query: 330 PPPPEKQAVGRF---KQDFIENRRAQMERMLQHIASNHVLQKDEDFILFL---------- 376
PP P+K V KQ+F+E RR +E+ L+ ++++ V++ ++ +FL
Sbjct: 221 PPRPDKSVVESQVMQKQEFVEQRRVALEKYLRRLSAHPVIRNSDELKVFLQVQGKLPLPM 280
Query: 377 ----TSEKWSQESKVREQISGSKASHDSNDISDIHISEL--KLLGSEDAERVLK--NGGL 428
S K+ +Q+ G + S + ++E+ G D R+ K +
Sbjct: 281 STDVASRMLDGAVKLPKQLFGEGGA------SAVPVTEVGQPARGGRDLLRLFKELRQSV 334
Query: 429 DTETGGSFMGLSFATAPKYKEPDQFFVDAAEKMDILEEQLKQLYKALELVDSQRSDLCSV 488
+ GGS P E D+ F++ EKM LE+Q+ + E + + D+
Sbjct: 335 SNDWGGS--------KPPVVEEDKEFLEKKEKMHDLEQQIINASQQAESLVKAQQDMGET 386
Query: 489 INEFSETLKALADLE--------LSNRTSDLLQNFAEVHLRIKESTSRSSMQDSLTLGIT 540
+ E L E R +D ++N A ++ + Q L T
Sbjct: 387 MGELGLAFIKLTKFENEEAVCNPQRTRAND-MKNLATAAVKASRFYRELNSQTVKHLD-T 444
Query: 541 IDDNLRAIGSVKAVLNQRKKLGYYILLVENDLNKKQTQFNKV--------SGNSANSEKA 592
+ + L + +V+ R + + ++L QT+ K+ G+ + K
Sbjct: 445 LHEYLGMMMAVQGAFADRSSALLTVQTLLSELPSLQTRVEKLEAASSKVFGGDKSRIRKI 504
Query: 593 TSIENELRILTSRCNKIKQEWQTIAEVIRKDVNQHDVDTIEDFRNNMEIYLESAIESQKE 652
++ +++ N + ++ I E R +V + D + DF N M+ ++ + + ++
Sbjct: 505 EELKETIKVTEDAKNVAIKGYERIKENNRSEVERLDRERRADFMNMMKGFVVNQVGYAEK 564
Query: 653 CIEIW 657
+W
Sbjct: 565 MGNVW 569
>At5g07120 [U] KOG2273 Membrane coat complex Retromer subunit VPS5/SNX1
Sorting nexins and related PX domain-containing proteins
Length = 554
Score = 78.6 bits (192), Expect = 3e-14
Identities = 94/454 (20%), Positives = 190/454 (41%), Gaps = 70/454 (15%)
Query: 253 KTNSTMSSSNTQETIEKFQISVVDPMKIGDIT-------SVYVEYTVISKSNLLE--GKP 303
+++ ++S S + + + +I+V +P K + T S Y+ Y + +++NL + G
Sbjct: 107 QSSDSLSRSPSSLSSDYIKITVSNPQKEQEATNSMIPGGSTYITYQITTRTNLSDYGGSE 166
Query: 304 TRVKRRYRDFRWLYRQLQHNHWGKIIPPPPEKQAVGRF---KQDFIENRRAQMERMLQHI 360
V+RR+RD L +L ++ G IPP P+K V KQ+F+E RR +E+ L+ +
Sbjct: 167 FSVRRRFRDIVTLADRLAESYRGFCIPPRPDKSIVESQVMQKQEFVEQRRVALEKYLRRL 226
Query: 361 ASNHVLQKDEDFILFL--------------TSEKWSQESKVREQISGSKASHDSNDISDI 406
++ V++ ++ +FL S K+ +Q+ G S ++
Sbjct: 227 VAHPVIRNSDELKVFLQAQGKLPLATSTDVASRMLDGAVKLPKQLFGEGGGASSVEVVQP 286
Query: 407 HISELKLLGSEDAERVLKN--GGLDTETGGSFMGLSFATAPKYKEPDQFFVDAAEKMDIL 464
G D R+ K + + GGS P E D+ F++ EKM L
Sbjct: 287 G------RGGRDFLRMFKELRQSVSNDWGGS--------KPPVVEEDKEFLEKKEKMYDL 332
Query: 465 EEQLKQLYKALELVDSQRSDLCSVINEFSETLKALADLE-----------LSNRTSDLLQ 513
E+Q+ + E + + D+ + E L E +N +L
Sbjct: 333 EQQIINASQQAESLVKAQQDMGETMGELGLAFIKLTKFENEEAVFNSQRARANDMKNLAT 392
Query: 514 NFAEVHLRIKESTSRS-----SMQDSLTLGITID----DNLRAIGSVKAVLNQRKKLGYY 564
+ + +E S++ ++ D L L + + D A+ +V+ +L++ L
Sbjct: 393 SAVKASRFYRELNSQTVKHLDTLHDYLGLMMAVQGAFADRSSALLTVQTLLSELSSL--- 449
Query: 565 ILLVENDLNKKQTQFNKV-SGNSANSEKATSIENELRILTSRCNKIKQEWQTIAEVIRKD 623
E K + +KV G+ + +K ++ +++ N +E++ I E +
Sbjct: 450 ----EARAEKLEVASSKVFGGDKSRIKKIEELKETIKVTEDSKNVAIREYEQIKENNWSE 505
Query: 624 VNQHDVDTIEDFRNNMEIYLESAIESQKECIEIW 657
V + D + DF N M+ ++ + + ++ +W
Sbjct: 506 VERLDRERRADFLNMMKGFVANQVGYAEKIANVW 539
>Hs7706715 [U] KOG2273 Membrane coat complex Retromer subunit VPS5/SNX1
Sorting nexins and related PX domain-containing proteins
Length = 387
Score = 76.6 bits (187), Expect = 1e-13
Identities = 44/124 (35%), Positives = 66/124 (52%), Gaps = 6/124 (4%)
Query: 272 ISVVDPMKIGDITSVYVEYTVISKSNL--LEGKPTRVKRRYRDFRWLYRQLQHNHWGKII 329
I+V +P ++ Y +I+K++ + V+RRY+DF WL +L+ H II
Sbjct: 34 ITVDEPESHVTTIETFITYRIITKTSRGEFDSSEFEVRRRYQDFLWLKGKLEEAHPTLII 93
Query: 330 PPPPEK----QAVGRFKQDFIENRRAQMERMLQHIASNHVLQKDEDFILFLTSEKWSQES 385
PP PEK V RF DFIE RR + + L IA + L +EDF +FLT++ W S
Sbjct: 94 PPLPEKFIVKGMVERFNDDFIETRRKALHKFLNRIADHPTLTFNEDFKIFLTAQAWELSS 153
Query: 386 KVRE 389
++
Sbjct: 154 HKKQ 157
>Hs22056379 [U] KOG2528 Sorting nexin SNX9/SH3PX1 and related proteins
Length = 574
Score = 66.6 bits (161), Expect = 1e-10
Identities = 42/126 (33%), Positives = 63/126 (49%), Gaps = 10/126 (7%)
Query: 270 FQISVVDPMKIGDITSV--YVEYTVISKSNLLEGKPTRVKRRYRDFRWLYRQLQHNHWGK 327
F SV DP K + Y+ Y + + V RRY+ F WLY +L H
Sbjct: 230 FACSVEDPTKQTKFKGIKSYISYKLTPTH-----AASPVYRRYKHFDWLYNRLLHKFTVI 284
Query: 328 IIPPPPEKQAVGRFKQDFIENRRAQMERMLQHIASNHVLQKDEDFILFLT---SEKWSQE 384
+P PEKQA GRF++DFIE R+ ++ + H+ S+ VL + E F FL+ ++W
Sbjct: 285 SVPHLPEKQATGRFEEDFIEKRKRRLILWMDHMTSHPVLSQYEGFQHFLSCLDDKQWKMG 344
Query: 385 SKVREQ 390
+ E+
Sbjct: 345 KRRAEK 350
>Hs22045020 [U] KOG2273 Membrane coat complex Retromer subunit VPS5/SNX1
Sorting nexins and related PX domain-containing proteins
Length = 333
Score = 66.2 bits (160), Expect = 1e-10
Identities = 36/99 (36%), Positives = 58/99 (58%), Gaps = 6/99 (6%)
Query: 287 YVEYTVISKSNLLEGKPTR--VKRRYRDFRWLYRQLQHNHWGKIIPPPPEK----QAVGR 340
Y+ Y + +KS +E V+RRY+DF WL +L+ + +IPP PEK V R
Sbjct: 4 YITYRITTKSTRVEFDLPEYSVRRRYQDFDWLRSKLEESQPTHLIPPLPEKFVVKGVVDR 63
Query: 341 FKQDFIENRRAQMERMLQHIASNHVLQKDEDFILFLTSE 379
F ++F+E RR +++ L+ I + VL +E F +FLT++
Sbjct: 64 FSEEFVETRRKALDKFLKRITDHPVLSFNEHFNIFLTAK 102
>Hs16418371 [U] KOG2528 Sorting nexin SNX9/SH3PX1 and related proteins
Length = 628
Score = 65.1 bits (157), Expect = 3e-10
Identities = 44/135 (32%), Positives = 65/135 (47%), Gaps = 13/135 (9%)
Query: 264 QETIEKFQISVVDPMKIGDITSV--YVEYTVISKSNLLEGKPTRVKRRYRDFRWLYRQLQ 321
QE FQ ++ DP K + Y+ Y ++ + V RRY+ F WLY +L
Sbjct: 270 QENPYPFQCTIDDPTKQTKFKGMKSYISYKLVPTHTQVP-----VHRRYKHFDWLYARLA 324
Query: 322 HNHWGKIIPPPPEKQAVGRFKQDFIENRRAQMERMLQHIASNHVLQKDEDFILFLT---- 377
+P PEKQA GRF++DFI RR + + H+AS+ VL + + F FLT
Sbjct: 325 EKFPVISVPHLPEKQATGRFEEDFISKRRKGLIWWMNHMASHPVLAQCDVFQHFLTCPSS 384
Query: 378 --SEKWSQESKVREQ 390
+ W Q + E+
Sbjct: 385 TDEKAWKQGKRKAEK 399
>YJL036w [U] KOG2273 Membrane coat complex Retromer subunit VPS5/SNX1
Sorting nexins and related PX domain-containing proteins
Length = 423
Score = 62.0 bits (149), Expect = 3e-09
Identities = 92/427 (21%), Positives = 166/427 (38%), Gaps = 75/427 (17%)
Query: 270 FQISVVDPMK-IGD--ITSVYVEYTVISKSNLLEGKPTR--------VKRRYRDFRWLYR 318
F+I V DP K GD +S YV Y + +K+N R V RRY D L+
Sbjct: 28 FEIIVSDPQKRTGDPGSSSGYVSYQISTKTNNTSFYDNRGDPESIIVVHRRYSDLLLLHD 87
Query: 319 QLQHNHWGKIIPPPPEKQ-----AVGRFKQDFIENRRAQMERMLQHIASNHVLQKDEDFI 373
L + IIPP P+K+ A RF Q F + R ++ L+ ++ + L + + F
Sbjct: 88 ILLNRFPTCIIPPLPDKKVFQYIAGDRFSQRFTQKRCHSLQNFLRRVSLHPDLSQSKVFK 147
Query: 374 LFLTSEKWSQESKVREQISGSKASHDSNDISDIHISELKLLGSEDAERV---LKNGGLDT 430
FL S+ W KV + + ++++D ++ K + ++ E K+ LD
Sbjct: 148 TFLVSKDWESHRKVLQ----DSLQPNKDEVTDAFMNAFKTVHKQNEEFTEIREKSDKLD- 202
Query: 431 ETGGSFMGLSFATAPKYKEPDQFFVDAAEKMDILEEQLKQLYKAL----ELVDSQRSDLC 486
T K D+ F +K D + E +L L ELV + +L
Sbjct: 203 -----------RTVTKI---DKLFHKVVKKNDSMSEDYTKLGSNLQELQELVTGENEELA 248
Query: 487 SVINEFSETLKALA----------DLELSNRTSDLLQNFAE-----VHLRIKESTSRSSM 531
+ + F+E + L+ D E D L+++ + + L+ ++ +
Sbjct: 249 AKLKIFNEGVTQLSYGLQDLTKYLDYEYIVDLKD-LEHYIDSMRQLIKLKDQKQIDYEEL 307
Query: 532 QDSLTLGITIDDNLRAIGSVKAVLNQRKKLGYYILLVENDLNKKQTQFNKVSGNSANSEK 591
D LT I +NL + GY N K + ++ ++ EK
Sbjct: 308 SDYLTRSIKEKNNLIS--------------GYG---GSNFFANKLEELAGINQEASRREK 350
Query: 592 ATSIENELRILTSRCNKIKQEWQTIAEVIRKDVNQHDVDTIEDFRNNMEIYLESAIESQK 651
+E ++ LT K+ + K+++ + + + ++ + IE +
Sbjct: 351 INKLEGKITSLTGELENAKKVADGFEQECLKEIDHFESVKTAEIKKSLGSLADHHIEFYE 410
Query: 652 ECIEIWE 658
+E WE
Sbjct: 411 RILEAWE 417
>SPAC6F6.12 [U] KOG2273 Membrane coat complex Retromer subunit VPS5/SNX1
Sorting nexins and related PX domain-containing proteins
Length = 401
Score = 61.2 bits (147), Expect = 5e-09
Identities = 87/392 (22%), Positives = 157/392 (39%), Gaps = 63/392 (16%)
Query: 252 PKTNSTMSSSNTQETIEKFQISVVDPMK-IGDITSVYVEYTVISKSNL--LEGKPTRVKR 308
P TNST Q V +P K + +V Y +I+K+NL +V+R
Sbjct: 10 PSTNST----------HFLQCLVTEPRKELQGSRDTHVSYLIITKTNLSIFTRAECKVRR 59
Query: 309 RYRDFRWLYRQLQHNHWGKIIPPPPEKQAV-----GRFKQDFIENRRAQMERMLQHIASN 363
R+ DF L L + ++PP P K + GRF +FI R + R + A +
Sbjct: 60 RFSDFVKLQEILSRMNEDCVVPPLPAKHKLEYIKGGRFSDNFINRRAKLLNRYITRCALH 119
Query: 364 HVLQKDEDFILFLTSEKWSQESKVREQISGSKASHDSNDISDIHISELKLLGSEDAERVL 423
VL + FI FL + W+ + Q + S ++ISD ++ L E E +
Sbjct: 120 PVLHQSPHFIAFLENPNWNNYVRFFIQPKLNNTS-KLDEISDSLLNAFSKLKEEPTEFDI 178
Query: 424 KNGGLDTETGGSFMGLSFATAPKYKEPDQFFVDAAEKMDILEEQLKQLYKALELVDSQRS 483
+ ++ Q F+ ++ ++L +L KALE S
Sbjct: 179 Q-----------------------RDHVQQFMFGISNLEGSIQKLLRLEKALE---SDYE 212
Query: 484 DLCSVINEFSETLKALADLELSNRTSDLLQNFAEVHLRIKESTSRSSMQDSLTLGI-TID 542
D+ + + +AL D+ + + + L Q T +++ + LTL + TI
Sbjct: 213 DVSIQFDRLASLDQAL-DVPIESIQNALQQT----------GTEYANLTEKLTLLLDTIK 261
Query: 543 DNLRAIGSVKAVLNQRKKLGYYILLVENDLNKKQTQFNKVSGNSANSEKATSIENELRIL 602
D S+K +L +R + + ++ K + +K+S +N + ++LR +
Sbjct: 262 DVESYAHSLKELLKRRDQKQQDVEALQEYSAKLSLERDKISSGGSNGFSLSKTLDDLRGI 321
Query: 603 ------TSRCNKIKQEWQTIAEVIRKDVNQHD 628
R ++ E Q + + I++ HD
Sbjct: 322 DHNDTRLKRLEHVQSELQAVEQAIQEASAVHD 353
>Hs7019539 [U] KOG2527 Sorting nexin SNX11
Length = 264
Score = 61.2 bits (147), Expect = 5e-09
Identities = 40/122 (32%), Positives = 59/122 (47%), Gaps = 3/122 (2%)
Query: 261 SNTQETIEKFQISVVDPMKIGDIT-SVYVEYTVI--SKSNLLEGKPTRVKRRYRDFRWLY 317
S QE E + V DP + + + YV+Y + + S K + V+RRYR+F WL
Sbjct: 2 SENQEQEEVITVRVQDPRVQNEGSWNSYVDYKIFLHTNSKAFTAKTSCVRRRYREFVWLR 61
Query: 318 RQLQHNHWGKIIPPPPEKQAVGRFKQDFIENRRAQMERMLQHIASNHVLQKDEDFILFLT 377
+QLQ N +P P K +FIE RR ++ L+ + + VL D LFL
Sbjct: 62 KQLQRNAGLVPVPELPGKSTFFGTSDEFIEKRRQGLQHFLEKVLQSVVLLSDSQLHLFLQ 121
Query: 378 SE 379
S+
Sbjct: 122 SQ 123
>CE19073 [U] KOG2528 Sorting nexin SNX9/SH3PX1 and related proteins
Length = 361
Score = 59.3 bits (142), Expect = 2e-08
Identities = 37/126 (29%), Positives = 64/126 (50%), Gaps = 2/126 (1%)
Query: 267 IEKFQISVVDPMKIGDITSVYVEYTVISKSNLLEGKPTRVKRRYRDFRWLYRQLQHNHWG 326
I+++ +VD K + S ++ L +V RRY+ F WL+ QL +
Sbjct: 11 IQQYYTCIVDKPKKESKLKGLKSFIAYSITSSLTNIQRQVSRRYKHFDWLHEQLSAKYVL 70
Query: 327 KIIPPPPEKQAVGRFKQDFIENRRAQMERMLQHIASNHVLQKDEDFILFL--TSEKWSQE 384
IPP PEKQ GR+++D I++R+ ++ + I + VL + E ++ F+ T EK +
Sbjct: 71 IPIPPLPEKQVAGRYEEDLIDHRKHILQLWVNKICRHPVLSQSEVWLHFISCTDEKDWKN 130
Query: 385 SKVREQ 390
K R +
Sbjct: 131 GKRRAE 136
>CE16547 [U] KOG2527 Sorting nexin SNX11
Length = 162
Score = 57.8 bits (138), Expect = 5e-08
Identities = 35/118 (29%), Positives = 61/118 (51%), Gaps = 14/118 (11%)
Query: 271 QISVVDPMKIGDITSVYVEYTVISKSNL--LEGKPTRVKRRYRDFRWLYRQLQHNHWGKI 328
+I V++P+ G Y +Y + +SNL + K + V+RRY DF W+ +L+ + KI
Sbjct: 30 EIEVINPITHGVGKMRYTDYEIRMRSNLPVFKQKESSVRRRYSDFEWVRAELERD--SKI 87
Query: 329 IPPP----------PEKQAVGRFKQDFIENRRAQMERMLQHIASNHVLQKDEDFILFL 376
+ P P + G F+++FIENRR +E + +A + + Q + +FL
Sbjct: 88 VVPTLPGKSFKRQLPFRSDDGIFEEEFIENRRKALELFINKVAGHPLAQNERSLHIFL 145
>7294889 [U] KOG2528 Sorting nexin SNX9/SH3PX1 and related proteins
Length = 531
Score = 56.6 bits (135), Expect = 1e-07
Identities = 26/72 (36%), Positives = 43/72 (59%)
Query: 306 VKRRYRDFRWLYRQLQHNHWGKIIPPPPEKQAVGRFKQDFIENRRAQMERMLQHIASNHV 365
V RRY+ F WL+ +L +PP P+KQ GR+++ F+E+RR Q++ + + + V
Sbjct: 218 VSRRYKHFDWLHERLVDKFCLIPVPPLPDKQISGRYEEQFVEHRRVQLQEFVDWVCRHPV 277
Query: 366 LQKDEDFILFLT 377
+ K E + FLT
Sbjct: 278 ISKCEVWYHFLT 289
>Hs7019541 [U] KOG2527 Sorting nexin SNX11
Length = 162
Score = 56.2 bits (134), Expect = 2e-07
Identities = 36/121 (29%), Positives = 62/121 (50%), Gaps = 14/121 (11%)
Query: 271 QISVVDPMKIGDITSVYVEYTVISKSNL--LEGKPTRVKRRYRDFRWLYRQLQHNHWGKI 328
+I + +P +G + + Y V ++NL + K + V+RRY DF WL +L+ + KI
Sbjct: 31 EIDIFNPQTVGVGRARFTTYEVRMRTNLPIFKLKESCVRRRYSDFEWLKNELERD--SKI 88
Query: 329 IPPPPEKQAVGR----------FKQDFIENRRAQMERMLQHIASNHVLQKDEDFILFLTS 378
+ PP +A+ R F++ FIE RR +E+ + IA + + Q + +FL
Sbjct: 89 VVPPLPGKALKRKLPFRGDEGIFEESFIEERRQGLEQFINKIAGHPLAQNERCLHMFLQE 148
Query: 379 E 379
E
Sbjct: 149 E 149
>SPBC1711.11 [U] KOG2273 Membrane coat complex Retromer subunit VPS5/SNX1
Sorting nexins and related PX domain-containing proteins
Length = 390
Score = 54.7 bits (130), Expect = 4e-07
Identities = 44/168 (26%), Positives = 77/168 (45%), Gaps = 17/168 (10%)
Query: 275 VDPMKIGDITSVYVEYTVISKSNL--LEGKPTRVKRRYRDFRWLYRQLQHNHWGKIIPPP 332
++ ++ GD +V Y + ++S+L E K V+RRY+DF L+ L H++ G IPP
Sbjct: 11 IETLRSGD---TFVSYEIETESDLPVFEDKKFSVRRRYKDFEMLHNILSHDYNGYAIPPL 67
Query: 333 PEKQAVGRFKQD-----FIENRRAQMERMLQHIASNHVLQKDEDFILFLTSEKWS---QE 384
P K V F FI R ++ L +++ V+ FL + W
Sbjct: 68 PRKYTVSSFSGGSLSPIFIARRMQSLQTFLDRCSTHPVISNSMHMYQFLENNSWKSYYHN 127
Query: 385 SKVREQISGSKASHDSNDISDIHISELKLLGS---EDAERVLKNGGLD 429
+ ++ + + SK ++ S I + I L E A+++L+N D
Sbjct: 128 AWMQSENTKSKGNNVSGGI-ESSIQNLDPYAQSLYETAKQLLQNADTD 174
>Hs4507143 [U] KOG2527 Sorting nexin SNX11
Length = 162
Score = 53.1 bits (126), Expect = 1e-06
Identities = 38/133 (28%), Positives = 63/133 (46%), Gaps = 17/133 (12%)
Query: 271 QISVVDPMKIGDITSVYVEYTVISKSNL--LEGKPTRVKRRYRDFRWLYRQLQHNHWGKI 328
+I V +P +G + Y + K+NL + K + V+RRY DF WL +L+ K+
Sbjct: 30 EIDVSNPQTVGVGRGRFTTYEIRVKTNLPIFKLKESTVRRRYSDFEWLRSELERE--SKV 87
Query: 329 IPPP----------PEKQAVGRFKQDFIENRRAQMERMLQHIASNHVLQKDEDFILFLTS 378
+ PP P + G F +FIE R+ +E+ + +A + + Q + +FL
Sbjct: 88 VVPPLPGKAFLRQLPFRGDDGIFDDNFIEERKQGLEQFINKVAGHPLAQNERCLHMFLQD 147
Query: 379 E---KWSQESKVR 388
E K SK+R
Sbjct: 148 EIIDKSYTPSKIR 160
>7299654 [U] KOG2527 Sorting nexin SNX11
Length = 167
Score = 52.4 bits (124), Expect = 2e-06
Identities = 37/119 (31%), Positives = 59/119 (49%), Gaps = 15/119 (12%)
Query: 271 QISVVDPMK-IGDITSVYVEYTVISKSNL--LEGKPTRVKRRYRDFRWLYRQLQHNHWGK 327
+I VV+P+ + Y +Y V ++NL + K + V+RRY DF WL +L+ + K
Sbjct: 34 EIDVVNPLTTMAAGKKRYTDYEVRMRTNLPVFKVKESSVRRRYSDFEWLRNELERD--SK 91
Query: 328 IIPPP----------PEKQAVGRFKQDFIENRRAQMERMLQHIASNHVLQKDEDFILFL 376
I+ PP P + G F + FIE RR +E + IA + + Q + +FL
Sbjct: 92 IVVPPLPGKAWKRQMPFRGDEGIFDESFIEERRKGLEAFINKIAGHPLAQNERCLHMFL 150
>Hs7706706 [U] KOG2528 Sorting nexin SNX9/SH3PX1 and related proteins
Length = 595
Score = 52.0 bits (123), Expect = 3e-06
Identities = 36/133 (27%), Positives = 65/133 (48%), Gaps = 15/133 (11%)
Query: 270 FQISVVDPMKIGDITSV--YVEYTVISKSNLLEGKPTRVKRRYRDFRWLYRQLQHNHWGK 327
F V DP K + + Y+EY + + V RY+ F WLY +L +G
Sbjct: 250 FDCVVADPRKGSKMYGLKSYIEYQLTPTNT-----NRSVNHRYKHFDWLYERLLVK-FGS 303
Query: 328 IIPPP--PEKQAVGRFKQDFIENRRAQMERMLQHIASNHVLQKDE---DFILFLTSEKW- 381
IP P P+KQ GRF+++FI+ R +++ + + + V+ + E F+ F ++W
Sbjct: 304 AIPIPSLPDKQVTGRFEEEFIKMRMERLQAWMTRMCRHPVISESEVFQQFLNFRDEKEWK 363
Query: 382 -SQESKVREQISG 393
+ R++++G
Sbjct: 364 TGKRKAERDELAG 376
>SPBC887.06c [U] KOG2527 Sorting nexin SNX11
Length = 143
Score = 50.8 bits (120), Expect = 6e-06
Identities = 28/99 (28%), Positives = 51/99 (51%), Gaps = 2/99 (2%)
Query: 271 QISVVDPMKIGDITSVYVEYTVISKSNL--LEGKPTRVKRRYRDFRWLYRQLQHNHWGKI 328
+I V++P G +++ Y ++ ++N+ + V+RRY +F + L+
Sbjct: 26 EIDVINPQTHGIGRNMFTTYEIVCRTNMPYFRLHNSSVRRRYSEFEKFHDMLERESGRVS 85
Query: 329 IPPPPEKQAVGRFKQDFIENRRAQMERMLQHIASNHVLQ 367
IPP P K RF+ D IE RR +E L+ +A + ++Q
Sbjct: 86 IPPLPGKIFTQRFRDDVIEERRQGLENFLRLVAGHPLIQ 124
>Hs22065944 [U] KOG2273 Membrane coat complex Retromer subunit VPS5/SNX1
Sorting nexins and related PX domain-containing proteins
Length = 278
Score = 50.8 bits (120), Expect = 6e-06
Identities = 33/109 (30%), Positives = 52/109 (47%), Gaps = 6/109 (5%)
Query: 264 QETIEKFQISVVDPMKIGDITSVYVEYTVISKSNL--LEGKPTRVKRRYRDFRWLYRQLQ 321
+ +++ I+V P ++ Y++I+KS+ + V+RRY+ F WL R+L+
Sbjct: 26 ERDLKEHFITVDKPESYVTTIETFITYSIITKSSCGEFDSSEFEVRRRYQGFLWLKRKLE 85
Query: 322 HNHWGKIIPPPPE----KQAVGRFKQDFIENRRAQMERMLQHIASNHVL 366
IPP PE K V FK DFIE R + + L A + L
Sbjct: 86 EAQPTLNIPPFPEKFIVKGMVEHFKDDFIETCRKALHKFLSRTADHPTL 134
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.311 0.129 0.358
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 39,359,193
Number of Sequences: 60738
Number of extensions: 1725469
Number of successful extensions: 5423
Number of sequences better than 1.0e-05: 29
Number of HSP's better than 0.0 without gapping: 7
Number of HSP's successfully gapped in prelim test: 22
Number of HSP's that attempted gapping in prelim test: 5361
Number of HSP's gapped (non-prelim): 45
length of query: 665
length of database: 30,389,216
effective HSP length: 113
effective length of query: 552
effective length of database: 23,525,822
effective search space: 12986253744
effective search space used: 12986253744
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)