ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactVI4500 good C KOG1494 Energy production and conversion NAD-dependent malate dehydrogenase
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactVI4500 1565937 1564924 -338
(338 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YDL078c [C] KOG1494 NAD-dependent malate dehydrogenase 345 5e-95
YKL085w [C] KOG1494 NAD-dependent malate dehydrogenase 269 4e-72
7300357 [C] KOG1494 NAD-dependent malate dehydrogenase 248 7e-66
At3g15020 [C] KOG1494 NAD-dependent malate dehydrogenase 237 2e-62
HsM5174541 [C] KOG1494 NAD-dependent malate dehydrogenase 233 4e-61
Hs21735621 [C] KOG1494 NAD-dependent malate dehydrogenase 233 4e-61
SPCC306.08c [C] KOG1494 NAD-dependent malate dehydrogenase 229 4e-60
CE09512 [C] KOG1494 NAD-dependent malate dehydrogenase 229 4e-60
At1g53240 [C] KOG1494 NAD-dependent malate dehydrogenase 226 4e-59
At3g47520 [C] KOG1494 NAD-dependent malate dehydrogenase 225 6e-59
At2g22780 [C] KOG1494 NAD-dependent malate dehydrogenase 220 3e-57
YOL126c [C] KOG1494 NAD-dependent malate dehydrogenase 219 3e-57
At5g09660 [C] KOG1494 NAD-dependent malate dehydrogenase 219 3e-57
7294520 [C] KOG1494 NAD-dependent malate dehydrogenase 209 5e-54
7294521 [C] KOG1494 NAD-dependent malate dehydrogenase 204 2e-52
SPAC186.08c [C] KOG1495 Lactate dehydrogenase 65 1e-10
Hs4504973 [C] KOG1495 Lactate dehydrogenase 60 6e-09
At4g17260 [C] KOG1495 Lactate dehydrogenase 59 8e-09
At5g43330 [C] KOG1496 Malate dehydrogenase 55 1e-07
At5g56720 [C] KOG1496 Malate dehydrogenase 54 2e-07
Hs22061164 [C] KOG1495 Lactate dehydrogenase 54 3e-07
At1g04410 [C] KOG1496 Malate dehydrogenase 53 6e-07
Hs5031857 [C] KOG1495 Lactate dehydrogenase 52 9e-07
CE20820 [C] KOG1496 Malate dehydrogenase 52 9e-07
Hs5174539 [C] KOG1496 Malate dehydrogenase 51 2e-06
Hs15082234 [C] KOG1495 Lactate dehydrogenase 50 6e-06
7295348 [C] KOG1495 Lactate dehydrogenase 50 6e-06
>YDL078c [C] KOG1494 NAD-dependent malate dehydrogenase
Length = 343
Score = 345 bits (885), Expect = 5e-95
Identities = 180/339 (53%), Positives = 243/339 (71%), Gaps = 10/339 (2%)
Query: 1 MVSVTVLGSSGGIGQPLSLLLKLDPHVSSLRLYDLKLSHGNATDLSHIDTNSTSEGFNTA 60
MV V +LG+SGG+GQPLSLLLKL P+VS L LYD++ + G DLSHI+TNS+ G++
Sbjct: 1 MVKVAILGASGGVGQPLSLLLKLSPYVSELALYDIRAAEGIGKDLSHINTNSSCVGYDKD 60
Query: 61 EIGQALKGAQLVIIPAGIPRKPGMSRDDLFKINAKIIKSLTVQIAEHAPDARILVISNPV 120
I L AQ+V+IPAG+PRKPG++RDDLFK+NA I+KSL + + AP+ARILVISNPV
Sbjct: 61 SIENTLSNAQVVLIPAGVPRKPGLTRDDLFKMNAGIVKSLVTAVGKFAPNARILVISNPV 120
Query: 121 NSLVPIVYETLQSMGKFQAGKVMGITTLDIIRSHTFLVDIIGRKAYSVEKLKD------A 174
NSLVPI ETL+ MGKF+ G VMG+T LD++R+ TFLVD + K + + +D
Sbjct: 121 NSLVPIAVETLKKMGKFKPGNVMGVTNLDLVRAETFLVDYLMLKNPKIGQEQDKTTMHRK 180
Query: 175 VTVVGGHSGETIIPIFTDQKFYRRLRDSNVYESYVHRVQFGGDEVVKAKDGSGSATLSMA 234
VTV+GGHSGETIIPI TD+ +L YE ++HRVQFGGDE+VKAK G+GSATLSMA
Sbjct: 181 VTVIGGHSGETIIPIITDKSLVFQL--DKQYEHFIHRVQFGGDEIVKAKQGAGSATLSMA 238
Query: 235 WAGYTFAKKLLNSLHLNTAGDQHPIPTFVYLPGLPGGKELQKKL-NTSVEFFSAPVKLEK 293
+AG FA+++L S H N + + FVYLPGL GK+ Q+ + + S+E+FS P+ L
Sbjct: 239 FAGAKFAEEVLRSFH-NEKPETESLSAFVYLPGLKNGKKAQQLVGDNSIEYFSLPIVLRN 297
Query: 294 GIVVAVEHEWVDKLNDDEKKLIAKCLPILEKNIKKGLAF 332
G VV+++ ++KL+ E++L+ + L KNI+KG +F
Sbjct: 298 GSVVSIDTSVLEKLSPREEQLVNTAVKELRKNIEKGKSF 336
>YKL085w [C] KOG1494 NAD-dependent malate dehydrogenase
Length = 334
Score = 269 bits (688), Expect = 4e-72
Identities = 158/333 (47%), Positives = 218/333 (65%), Gaps = 26/333 (7%)
Query: 4 VTVLGSSGGIGQPLSLLLKLDPHVSSLRLYDLKLSHGNATDLSHIDTNSTSEGFNTAE-- 61
VTVLG+ GGIGQPLSLLLKL+ V+ LRLYDLK + G ATDLSHI TNS +GF E
Sbjct: 20 VTVLGAGGGIGQPLSLLLKLNHKVTDLRLYDLKGAKGVATDLSHIPTNSVVKGFTPEEPD 79
Query: 62 -IGQALKGAQLVIIPAGIPRKPGMSRDDLFKINAKIIKSLTVQIAEHAPDARILVISNPV 120
+ ALK +V+IPAG+PRKPGM+RDDLF INA I++ L AE AP+A ILVISNPV
Sbjct: 80 GLNNALKDTDMVLIPAGVPRKPGMTRDDLFAINASIVRDLAAATAESAPNAAILVISNPV 139
Query: 121 NSLVPIVYETLQSMGKFQAGKVMGITTLDIIRSHTFLVDIIGRKAYSVEKLKDAVTVVGG 180
NS VPIV + L++ G + K+ G+TTLD IR+ F+ ++ + + ++ V V+GG
Sbjct: 140 NSTVPIVAQVLKNKGVYNPKKLFGVTTLDSIRAARFISEV-----ENTDPTQERVNVIGG 194
Query: 181 HSGETIIPIFTDQKFYRRLRDSNVYESYVHRVQFGGDEVVKAKDGSGSATLSMAWAGYTF 240
HSG TIIP+ + Q ++ + D +E +HR+QFGGDEVVKAK+G+GSATLSMA AG F
Sbjct: 195 HSGITIIPLIS-QTNHKLMSDDKRHE-LIHRIQFGGDEVVKAKNGAGSATLSMAHAGAKF 252
Query: 241 AKKLLNSLHLNTAGDQHPI-PTFVYLPGLPGGKELQKKLNTSVEFFSAPVKLEKGIVVAV 299
A +L+ G++ I P+FV P + +EFF++PV L + +
Sbjct: 253 ANAVLSGF----KGERDVIEPSFVDSPLFK---------SEGIEFFASPVTLGPDGIEKI 299
Query: 300 EHEWVDKLNDDEKKLIAKCLPILEKNIKKGLAF 332
+ +L+ +E++++ KC L+KNI+KG+ F
Sbjct: 300 HP--IGELSSEEEEMLQKCKETLKKNIEKGVNF 330
>7300357 [C] KOG1494 NAD-dependent malate dehydrogenase
Length = 336
Score = 248 bits (634), Expect = 7e-66
Identities = 147/332 (44%), Positives = 210/332 (62%), Gaps = 26/332 (7%)
Query: 4 VTVLGSSGGIGQPLSLLLKLDPHVSSLRLYDLKLSHGNATDLSHIDTNSTSEGFNTAE-I 62
VTV G++GGIGQPLSLLLK +P V+ L LYD+ + G A DLSHIDT S + GF A+ +
Sbjct: 27 VTVCGAAGGIGQPLSLLLKQNPLVTDLALYDIVHTPGVAADLSHIDTKSKTAGFIGADQL 86
Query: 63 GQALKGAQLVIIPAGIPRKPGMSRDDLFKINAKIIKSLTVQIAEHAPDARILVISNPVNS 122
G +LKG+ +V+IPAG+PRKPGM+RDDLF +NA IIK ++ IA++ P A + +I+NPVN+
Sbjct: 87 GDSLKGSDVVVIPAGVPRKPGMTRDDLFNVNAGIIKDISNSIAKNCPKALVAIITNPVNT 146
Query: 123 LVPIVYETLQSMGKFQAGKVMGITTLDIIRSHTFLVDIIGRKAYSVEKLKDAVTVVGGHS 182
VPI E L+ G + ++ G++TLD++R+ F+ +G +V+ + V+GGHS
Sbjct: 147 CVPIAAEILKKAGVYDPKRLFGVSTLDVVRARAFIGHALGVDPQTVQ-----IPVIGGHS 201
Query: 183 GETIIPIFT-DQKFYRRLRDSNVYESYVHRVQFGGDEVVKAKDGSGSATLSMAWAGYTFA 241
G TI+P+ + Q ++ +D+ E R+Q G EVVKAK G+GSATLSMA+AG FA
Sbjct: 202 GVTILPVLSQSQPLFKGNQDT--IEKLTVRIQEAGTEVVKAKAGAGSATLSMAYAGARFA 259
Query: 242 KKLLNSLHLNTAGDQHPIPTFVYLPGLPGGKELQKKLNTSVEFFSAPVKLEKGIVVAVEH 301
LL L+ G+++ I + T FFS P+ L K V E+
Sbjct: 260 GSLLKGLN----GEKNVIEC-----------SYVQSTVTEATFFSTPLVLGKNGV--QEN 302
Query: 302 EWVDKLNDDEKKLIAKCLPILEKNIKKGLAFS 333
+ KLND EKKL+ +P L+KNI+KG+ F+
Sbjct: 303 LGLPKLNDYEKKLLEAAIPELKKNIQKGIDFA 334
>At3g15020 [C] KOG1494 NAD-dependent malate dehydrogenase
Length = 341
Score = 237 bits (604), Expect = 2e-62
Identities = 145/335 (43%), Positives = 205/335 (60%), Gaps = 28/335 (8%)
Query: 4 VTVLGSSGGIGQPLSLLLKLDPHVSSLRLYDLKLSHGNATDLSHIDTNSTSEGF-NTAEI 62
V +LG++GGIGQPLSLL+KL+P VSSL LYD+ + G A D+ HI+T S G+ ++
Sbjct: 32 VVILGAAGGIGQPLSLLMKLNPLVSSLSLYDIANTPGVAADVGHINTRSQVSGYMGDDDL 91
Query: 63 GQALKGAQLVIIPAGIPRKPGMSRDDLFKINAKIIKSLTVQIAEHAPDARILVISNPVNS 122
G+AL+GA LVIIPAG+PRKPGM+RDDLF INA I+K+L++ IA++ P A + +ISNPVNS
Sbjct: 92 GKALEGADLVIIPAGVPRKPGMTRDDLFNINAGIVKNLSIAIAKYCPQALVNMISNPVNS 151
Query: 123 LVPIVYETLQSMGKFQAGKVMGITTLDIIRSHTFLVDIIGRKAYSVEKLKDAVTVVGGHS 182
VPI E + G + K+ G+TTLD++R+ TF G+ +V ++ V VVGGH+
Sbjct: 152 TVPIAAEIFKKAGTYDEKKLFGVTTLDVVRARTFYA---GKSDVNVAEVN--VPVVGGHA 206
Query: 183 GETIIPIFTDQKFYRRLRDSNVYESYVHRVQFGGDEVVKAKDGSGSATLSMAWAGYTFAK 242
G TI+P+F+ L D ++ + R Q GG EVV+AK G GSATLSMA+AG FA
Sbjct: 207 GITILPLFSQASPQANLSD-DLIRALTKRTQDGGTEVVEAKAGKGSATLSMAYAGALFAD 265
Query: 243 KLLNSLHLNTAGDQHPIPTFVYLPGLPGGKELQ--KKLNTSVEFFSAPVKLEKGIVVAVE 300
L L+ G+P E + T + FF++ V+L K V V
Sbjct: 266 ACLKGLN-----------------GVPNVVECSFVQSTITELPFFASKVRLGKNGVEEVL 308
Query: 301 HEWVDKLNDDEKKLIAKCLPILEKNIKKGLAFSKQ 335
+ L+D EK+ + L+ +I+KG+ F+ Q
Sbjct: 309 D--LGPLSDFEKEGLEALKAELKSSIEKGIKFANQ 341
>HsM5174541 [C] KOG1494 NAD-dependent malate dehydrogenase
Length = 338
Score = 233 bits (593), Expect = 4e-61
Identities = 142/338 (42%), Positives = 204/338 (60%), Gaps = 30/338 (8%)
Query: 4 VTVLGSSGGIGQPLSLLLKLDPHVSSLRLYDLKLSHGNATDLSHIDTNSTSEGF-NTAEI 62
V VLG+SGGIGQPLSLLLK P VS L LYD+ + G A DLSHI+T + +G+ ++
Sbjct: 27 VAVLGASGGIGQPLSLLLKNSPLVSRLTLYDIAHTPGVAADLSHIETKAAVKGYLGPEQL 86
Query: 63 GQALKGAQLVIIPAGIPRKPGMSRDDLFKINAKIIKSLTVQIAEHAPDARILVISNPVNS 122
LKG +V+IPAG+PRKPGM+RDDLF NA I+ +LT A+H P+A I VI+NPVNS
Sbjct: 87 PDCLKGCDVVVIPAGVPRKPGMTRDDLFNTNATIVATLTAACAQHCPEAMICVIANPVNS 146
Query: 123 LVPIVYETLQSMGKFQAGKVMGITTLDIIRSHTFLVDIIGRKAYSVEKLKDAVTVVGGHS 182
+PI E + G + K+ G+TTLDI+R++TF+ ++ G ++ + V V+GGH+
Sbjct: 147 TIPITAEVFKKHGVYNPNKIFGVTTLDIVRANTFVAELKG-----LDPARVNVPVIGGHA 201
Query: 183 GETIIPIFTDQKFYRRLRDSNVYESYVHRVQFGGDEVVKAKDGSGSATLSMAWAGYTFAK 242
G+TIIP+ + Q + + + R+Q G EVVKAK G+GSATLSMA+AG F
Sbjct: 202 GKTIIPLIS-QCTPKVDFPQDQLTALTGRIQEAGTEVVKAKAGAGSATLSMAYAGARFVF 260
Query: 243 KLLNSLHLNTAGDQHPIPTFVYLPGLPGGKELQ--KKLNTSVEFFSAPVKL-EKGIVVAV 299
L+++++ G G E K T +FS P+ L +KGI
Sbjct: 261 SLVDAMN-----------------GKEGVVECSFVKSQETECTYFSTPLLLGKKGI---E 300
Query: 300 EHEWVDKLNDDEKKLIAKCLPILEKNIKKGLAFSKQTK 337
++ + K++ E+K+I+ +P L+ +IKKG F K K
Sbjct: 301 KNLGIGKVSSFEEKMISDAIPELKASIKKGEDFVKTLK 338
>Hs21735621 [C] KOG1494 NAD-dependent malate dehydrogenase
Length = 338
Score = 233 bits (593), Expect = 4e-61
Identities = 142/338 (42%), Positives = 204/338 (60%), Gaps = 30/338 (8%)
Query: 4 VTVLGSSGGIGQPLSLLLKLDPHVSSLRLYDLKLSHGNATDLSHIDTNSTSEGF-NTAEI 62
V VLG+SGGIGQPLSLLLK P VS L LYD+ + G A DLSHI+T + +G+ ++
Sbjct: 27 VAVLGASGGIGQPLSLLLKNSPLVSRLTLYDIAHTPGVAADLSHIETKAAVKGYLGPEQL 86
Query: 63 GQALKGAQLVIIPAGIPRKPGMSRDDLFKINAKIIKSLTVQIAEHAPDARILVISNPVNS 122
LKG +V+IPAG+PRKPGM+RDDLF NA I+ +LT A+H P+A I VI+NPVNS
Sbjct: 87 PDCLKGCDVVVIPAGVPRKPGMTRDDLFNTNATIVATLTAACAQHCPEAMICVIANPVNS 146
Query: 123 LVPIVYETLQSMGKFQAGKVMGITTLDIIRSHTFLVDIIGRKAYSVEKLKDAVTVVGGHS 182
+PI E + G + K+ G+TTLDI+R++TF+ ++ G ++ + V V+GGH+
Sbjct: 147 TIPITAEVFKKHGVYNPNKIFGVTTLDIVRANTFVAELKG-----LDPARVNVPVIGGHA 201
Query: 183 GETIIPIFTDQKFYRRLRDSNVYESYVHRVQFGGDEVVKAKDGSGSATLSMAWAGYTFAK 242
G+TIIP+ + Q + + + R+Q G EVVKAK G+GSATLSMA+AG F
Sbjct: 202 GKTIIPLIS-QCTPKVDFPQDQLTALTGRIQEAGTEVVKAKAGAGSATLSMAYAGARFVF 260
Query: 243 KLLNSLHLNTAGDQHPIPTFVYLPGLPGGKELQ--KKLNTSVEFFSAPVKL-EKGIVVAV 299
L+++++ G G E K T +FS P+ L +KGI
Sbjct: 261 SLVDAMN-----------------GKEGVVECSFVKSQETECTYFSTPLLLGKKGI---E 300
Query: 300 EHEWVDKLNDDEKKLIAKCLPILEKNIKKGLAFSKQTK 337
++ + K++ E+K+I+ +P L+ +IKKG F K K
Sbjct: 301 KNLGIGKVSSFEEKMISDAIPELKASIKKGEDFVKTLK 338
>SPCC306.08c [C] KOG1494 NAD-dependent malate dehydrogenase
Length = 341
Score = 229 bits (584), Expect = 4e-60
Identities = 144/333 (43%), Positives = 200/333 (59%), Gaps = 28/333 (8%)
Query: 4 VTVLGSSGGIGQPLSLLLKLDPHVSSLRLYDLKLSHGNATDLSHIDTNSTSEGFNTAEIG 63
V VLG+ GGIGQPLS+LLKL+ VS L L+D++ + G A D+ HI+T S G+ + G
Sbjct: 31 VAVLGAGGGIGQPLSMLLKLNDKVSELALFDIRGAPGVAADIGHINTTSNVVGYAPDDKG 90
Query: 64 --QALKGAQLVIIPAGIPRKPGMSRDDLFKINAKIIKSLTVQIAEHAPDARILVISNPVN 121
+AL GA +VIIPAG+PRKPGM+RDDLF NA I++ L E P+A+ LV++NPVN
Sbjct: 91 LEKALNGADVVIIPAGVPRKPGMTRDDLFATNASIVRDLAFAAGETCPEAKYLVVTNPVN 150
Query: 122 SLVPIVYETLQSMGKFQAGKVMGITTLDIIRSHTFLVDIIGRKAYSVEKLKDAVTVVGGH 181
S VPI + L+ +G Q + G+TTLD +R+ F + KA + + VVGGH
Sbjct: 151 STVPIFKKALERVGVHQPKHLFGVTTLDSVRASRFTSQVTNGKAELLH-----IPVVGGH 205
Query: 182 SGETIIPIFTD--QKFYRRLRDSNVYESYVHRVQFGGDEVVKAKDGSGSATLSMAWAGYT 239
SG TI+P+ + + RD + +HR+QFGGDEVVKAK G+GSATLSMA+AG
Sbjct: 206 SGATIVPLLSQGGVELTGEKRD-----ALIHRIQFGGDEVVKAKAGAGSATLSMAYAGAR 260
Query: 240 FAKKLLNSLHLNTAGDQHPIPTFVYLPGLPGGKELQKKLNTSVEFFSAPVKLEKGIVVAV 299
A +L +L + ++ TFV P L K + ++FF++ V L K V +
Sbjct: 261 MASSVLRALAGESGVEE---CTFVESP-------LYK--DQGIDFFASRVTLGKDGVDTI 308
Query: 300 EHEWVDKLNDDEKKLIAKCLPILEKNIKKGLAF 332
V K+ND E+ L+ L L+K+I KG F
Sbjct: 309 HP--VGKINDYEESLLKVALGELKKSITKGEQF 339
>CE09512 [C] KOG1494 NAD-dependent malate dehydrogenase
Length = 341
Score = 229 bits (584), Expect = 4e-60
Identities = 142/332 (42%), Positives = 197/332 (58%), Gaps = 24/332 (7%)
Query: 4 VTVLGSSGGIGQPLSLLLKLDPHVSSLRLYDLKLSHGNATDLSHIDTNS-TSEGFNTAEI 62
V +LG++GGIGQPL LLLK DP V+ L LYD+ + G A DLSHID+N+ + E+
Sbjct: 31 VALLGAAGGIGQPLGLLLKQDPLVAHLALYDVVNTPGVAADLSHIDSNAKVTAHTGPKEL 90
Query: 63 GQALKGAQLVIIPAGIPRKPGMSRDDLFKINAKIIKSLTVQIAEHAPDARILVISNPVNS 122
A++ A +++IPAG+PRKPGM+RDDLF NA I++ L IA+ +P A I +I+NPVNS
Sbjct: 91 YAAVENADVIVIPAGVPRKPGMTRDDLFNTNAGIVRDLAAVIAKASPKALIAIITNPVNS 150
Query: 123 LVPIVYETLQSMGKFQAGKVMGITTLDIIRSHTFLVDIIGRKAYSVEKLKDAVTVVGGHS 182
VPI E L+ G + +V G+TTLD++RS F+ ++ G A K V VVGGH+
Sbjct: 151 TVPIASEVLKKAGVYDPKRVFGVTTLDVVRSQAFVSELKGHDA-----SKTVVPVVGGHA 205
Query: 183 GETIIPIFTDQKFYRRLRDSNVYESYVHRVQFGGDEVVKAKDGSGSATLSMAWAGYTFAK 242
G TIIP+ + K + + + R+Q G EVV AK G+GSATLSMA AG FA
Sbjct: 206 GITIIPLLSQVKPSTKFSEEEI-SKLTPRIQDAGTEVVNAKAGAGSATLSMALAGARFAN 264
Query: 243 KLLNSLHLNTAGDQHPIPTFVYLPGLPGGKELQKKLNTSVEFFSAPVKLEKGIVVAVEHE 302
L+ + G+++ +V + G VE+FS PV+L V +
Sbjct: 265 ALVRGI----KGEKNVQCAYVASDAVKG-----------VEYFSTPVELGPNGVEKI--L 307
Query: 303 WVDKLNDDEKKLIAKCLPILEKNIKKGLAFSK 334
V K++ E+KLI +P L KNI KG+AF K
Sbjct: 308 GVGKVSAYEQKLIDASVPELNKNIAKGVAFVK 339
>At1g53240 [C] KOG1494 NAD-dependent malate dehydrogenase
Length = 352
Score = 226 bits (576), Expect = 4e-59
Identities = 144/345 (41%), Positives = 202/345 (57%), Gaps = 37/345 (10%)
Query: 4 VTVLGSSGGIGQPLSLLLKLDPHVSSLRLYDLKLSHGNATDLSHIDTNSTSEGF-NTAEI 62
V +LG++GGIGQPL+LL+KL+P VSSL LYD+ + G A D+ HI+T S G+ +
Sbjct: 32 VAILGAAGGIGQPLALLMKLNPLVSSLSLYDIANTPGVAADVGHINTRSEVVGYMGDDNL 91
Query: 63 GQALKGAQLVIIPAGIPRKPGMSRDDLFKINAKIIKSLTVQIAEHAPDARILVISNPVNS 122
+AL+GA LVIIPAG+PRKPGM+RDDLF INA I+K+L IA++ P A I +ISNPVNS
Sbjct: 92 AKALEGADLVIIPAGVPRKPGMTRDDLFNINAGIVKNLCTAIAKYCPHALINMISNPVNS 151
Query: 123 LVPIVYETLQSMGKFQAGKVMGITTLDIIRSHTFLVDIIGRKAYSVEKLKDAVTVVGGHS 182
VPI E + G + K+ G+TTLD++R+ TF G+ V ++ V V+GGH+
Sbjct: 152 TVPIAAEIFKKAGMYDEKKLFGVTTLDVVRARTFYA---GKANVPVAEVN--VPVIGGHA 206
Query: 183 GETIIPIFTDQKFY----------RRLRDSNVYESYVHRVQFGGDEVVKAKDGSGSATLS 232
G TI+P+F+ + + S++ + R Q GG EVV+AK G GSATLS
Sbjct: 207 GVTILPLFSQVSSHFLSTQTVATPQANLSSDILTALTKRTQDGGTEVVEAKAGKGSATLS 266
Query: 233 MAWAGYTFAKKLLNSLHLNTAGDQHPIPTFVYLPGLPGGKELQKKLNTSVE--FFSAPVK 290
MA+AG FA L L+ G+P E +T E FF++ V+
Sbjct: 267 MAYAGALFADACLKGLN-----------------GVPDVIECSYVQSTITELPFFASKVR 309
Query: 291 LEKGIVVAVEHEWVDKLNDDEKKLIAKCLPILEKNIKKGLAFSKQ 335
L K V V + L+D EK+ + P L+ +I+KG+ F+ Q
Sbjct: 310 LGKNGVEEVLD--LGPLSDFEKEGLEALKPELKSSIEKGVKFANQ 352
>At3g47520 [C] KOG1494 NAD-dependent malate dehydrogenase
Length = 403
Score = 225 bits (574), Expect = 6e-59
Identities = 140/333 (42%), Positives = 198/333 (59%), Gaps = 22/333 (6%)
Query: 4 VTVLGSSGGIGQPLSLLLKLDPHVSSLRLYDLKLSHGNATDLSHIDTNSTSEGFN-TAEI 62
V VLG++GGIGQPLSLL+K+ P VS+L LYD+ G A DLSH +T S F +E+
Sbjct: 85 VAVLGAAGGIGQPLSLLIKMSPLVSTLHLYDIANVKGVAADLSHCNTPSQVRDFTGPSEL 144
Query: 63 GQALKGAQLVIIPAGIPRKPGMSRDDLFKINAKIIKSLTVQIAEHAPDARILVISNPVNS 122
LK +V+IPAG+PRKPGM+RDDLF INA I+K+L +AE+ P+A I +ISNPVNS
Sbjct: 145 ADCLKDVNVVVIPAGVPRKPGMTRDDLFNINANIVKTLVEAVAENCPNAFIHIISNPVNS 204
Query: 123 LVPIVYETLQSMGKFQAGKVMGITTLDIIRSHTFLVDIIGRKAYSVEKLKDAVTVVGGHS 182
VPI E L+ G + K+ G+TTLD++R++TF+ K V+ V V+GGH+
Sbjct: 205 TVPIAAEVLKKKGVYDPKKLFGVTTLDVVRANTFVSQKKNLKLIDVD-----VPVIGGHA 259
Query: 183 GETIIPIFTDQKFYRRLRDSNVYESYVHRVQFGGDEVVKAKDGSGSATLSMAWAGYTFAK 242
G TI+P+ + K D + E V R+Q G EVV AK G+GSATLSMA+A F +
Sbjct: 260 GITILPLLSKTKPSVNFTDEEIQELTV-RIQNAGTEVVDAKAGAGSATLSMAYAAARFVE 318
Query: 243 KLLNSLHLNTAGDQHPIPTFVYLPGLPGGKELQKKLNTSVEFFSAPVKLEKGIVVAVEHE 302
L + L+ GD + +FV + T + FF++ VK+ K + AV
Sbjct: 319 SSLRA--LDGDGDVYEC-SFV------------ESTLTDLPFFASRVKIGKNGLEAVIES 363
Query: 303 WVDKLNDDEKKLIAKCLPILEKNIKKGLAFSKQ 335
+ L + E+K + L+ +I KG+AF+ +
Sbjct: 364 DLQGLTEYEQKALEALKVELKASIDKGVAFANK 396
>At2g22780 [C] KOG1494 NAD-dependent malate dehydrogenase
Length = 354
Score = 220 bits (560), Expect = 3e-57
Identities = 135/333 (40%), Positives = 196/333 (58%), Gaps = 24/333 (7%)
Query: 4 VTVLGSSGGIGQPLSLLLKLDPHVSSLRLYDLKLSHGNATDLSHIDTNSTSEGF-NTAEI 62
V +LG++GGIGQPL++L+K++P VS L LYD+ + G D+SH+DT++ GF ++
Sbjct: 45 VAILGAAGGIGQPLAMLMKMNPLVSVLHLYDVANAPGVTADISHMDTSAVVRGFLGQPQL 104
Query: 63 GQALKGAQLVIIPAGIPRKPGMSRDDLFKINAKIIKSLTVQIAEHAPDARILVISNPVNS 122
+AL G LVIIPAG+PRKPGM+RDDLF INA I+++L+ IA+ P A + +ISNPVNS
Sbjct: 105 EEALTGMDLVIIPAGVPRKPGMTRDDLFNINAGIVRTLSEAIAKCCPKAIVNIISNPVNS 164
Query: 123 LVPIVYETLQSMGKFQAGKVMGITTLDIIRSHTFLVDIIGRKAYSVEKLKDAVTVVGGHS 182
VPI E + G F K+MG+T LD++R++TF+ +++ VE V VVGGH+
Sbjct: 165 TVPIAAEVFKKAGTFDPKKLMGVTMLDVVRANTFVAEVMSLDPREVE-----VPVVGGHA 219
Query: 183 GETIIPIFTDQKFYRRLRDSNVYESYVHRVQFGGDEVVKAKDGSGSATLSMAWAGYTFAK 242
G TI+P+ + K + E R+Q GG EVV+AK G+GSATLSMA+A FA
Sbjct: 220 GVTILPLLSQVKPPCSFTQKEI-EYLTDRIQNGGTEVVEAKAGAGSATLSMAYAAVEFAD 278
Query: 243 KLLNSLHLNTAGDQHPIPTFVYLPGLPGGKELQKKLNTSVEFFSAPVKLEKGIVVAVEHE 302
L L GD + + + T + FF++ V+L G E
Sbjct: 279 ACLRGLR----GDANIVECAYVASHV-----------TELPFFASKVRL--GRCGIDEVY 321
Query: 303 WVDKLNDDEKKLIAKCLPILEKNIKKGLAFSKQ 335
+ LN+ E+ + K L +I KG+ F+K+
Sbjct: 322 GLGPLNEYERMGLEKAKKELSVSIHKGVTFAKK 354
>YOL126c [C] KOG1494 NAD-dependent malate dehydrogenase
Length = 423
Score = 219 bits (559), Expect = 3e-57
Identities = 149/360 (41%), Positives = 206/360 (56%), Gaps = 33/360 (9%)
Query: 2 VSVTVLGSSGGIGQPLSLLLKLD------------PHVSSLRLYDLKLS--HGNATDLSH 47
+ + +LG++GGIGQ LSLLLK H+ L LYD+ +G DLSH
Sbjct: 60 LKIAILGAAGGIGQSLSLLLKAQLQYQLKESNRSVTHIH-LALYDVNQEAINGVTADLSH 118
Query: 48 IDTN-STSEGFNTAEIGQALKGAQLVIIPAGIPRKPGMSRDDLFKINAKIIKSLTVQIAE 106
IDT S S I L A +V+IPAG+PRKPGM+RDDLF +NA II L IAE
Sbjct: 119 IDTPISVSSHSPAGGIENCLHNASIVVIPAGVPRKPGMTRDDLFNVNAGIISQLGDSIAE 178
Query: 107 HAPDAR--ILVISNPVNSLVPIVYETL-----QSMGKFQAGKVMGITTLDIIRSHTFL-- 157
++ +LVISNPVNSLVP++ + QS ++MG+T LDI+R+ TFL
Sbjct: 179 CCDLSKVFVLVISNPVNSLVPVMVSNILKNHPQSRNSGIERRIMGVTKLDIVRASTFLRE 238
Query: 158 VDIIGRKAYSVEKLKDAVTVVGGHSGETIIPIFTDQKFYRRLRDSNVYESYVHRVQFGGD 217
++I V + D V V+GGHSGETIIP+F+ F RL + + + +HRVQ+GGD
Sbjct: 239 INIESGLTPRVNSMPD-VPVIGGHSGETIIPLFSQSNFLSRLNEDQL-KYLIHRVQYGGD 296
Query: 218 EVVKAKDGSGSATLSMAWAGY----TFAKKLLNSLHLNTAGDQHPIPTFVYLPGLPGGKE 273
EVVKAK+G GSATLSMA AGY F LL ++ P+ P PG +
Sbjct: 297 EVVKAKNGKGSATLSMAHAGYKCVVQFVSLLLGNIEQIHGTYYVPLKDANNFPIAPGADQ 356
Query: 274 LQKKLNTSVEFFSAPVKLEKGIVVAVEHEWVDKLNDDEK-KLIAKCLPILEKNIKKGLAF 332
L L ++F+ P+ + V V+++ V+++ND E+ +++ C+ L+KNI KGL F
Sbjct: 357 L-LPLVDGADYFAIPLTITTKGVSYVDYDIVNRMNDMERNQMLPICVSQLKKNIDKGLEF 415
>At5g09660 [C] KOG1494 NAD-dependent malate dehydrogenase
Length = 354
Score = 219 bits (559), Expect = 3e-57
Identities = 140/334 (41%), Positives = 199/334 (58%), Gaps = 26/334 (7%)
Query: 4 VTVLGSSGGIGQPLSLLLKLDPHVSSLRLYDLKLSHGNATDLSHIDTNSTSEGFNTA-EI 62
V +LG++GGIGQ LSLL+K++P VS L LYD+ + G D+SH+DT + GF A ++
Sbjct: 45 VAILGAAGGIGQSLSLLMKMNPLVSLLHLYDVVNAPGVTADVSHMDTGAVVRGFLGAKQL 104
Query: 63 GQALKGAQLVIIPAGIPRKPGMSRDDLFKINAKIIKSLTVQIAEHAPDARILVISNPVNS 122
AL G LVIIPAGIPRKPGM+RDDLFKINA I+K+L +A+ P+A + +ISNPVNS
Sbjct: 105 EDALTGMDLVIIPAGIPRKPGMTRDDLFKINAGIVKTLCEGVAKCCPNAIVNLISNPVNS 164
Query: 123 LVPIVYETLQSMGKFQAGKVMGITTLDIIRSHTFLVDIIGRKAYSVEKLKDAVTVVGGHS 182
VPI E + G + K++G+TTLD+ R++TF+ +++G V+ V VVGGH+
Sbjct: 165 TVPIAAEVFKKAGTYDPKKLLGVTTLDVARANTFVAEVLGLDPREVD-----VPVVGGHA 219
Query: 183 GETIIPIFTDQKFYRRLRDSNVYESYVHRVQFGGDEVVKAKDGSGSATLSMAWAGYTFAK 242
G TI+P+ + K + E +R+Q GG EVV+AK G+GSATLSMA+A FA
Sbjct: 220 GVTILPLLSQVKPPSSFTPQEI-EYLTNRIQNGGTEVVEAKAGAGSATLSMAYAAAKFAD 278
Query: 243 KLLNSLHLNTAGDQHPIP-TFVYLPGLPGGKELQKKLNTSVEFFSAPVKLEKGIVVAVEH 301
L L GD + + +FV T + FF+ V+L G A E
Sbjct: 279 ACLRGLR----GDANVVECSFV------------ASQVTELAFFATKVRL--GRTGAEEV 320
Query: 302 EWVDKLNDDEKKLIAKCLPILEKNIKKGLAFSKQ 335
+ LN+ E+ + K L +I+KG+ F ++
Sbjct: 321 YQLGPLNEYERIGLEKAKDELAGSIQKGVEFIRK 354
>7294520 [C] KOG1494 NAD-dependent malate dehydrogenase
Length = 347
Score = 209 bits (532), Expect = 5e-54
Identities = 127/332 (38%), Positives = 193/332 (57%), Gaps = 26/332 (7%)
Query: 2 VSVTVLGSSGGIGQPLSLLLKLDPHVSSLRLYDLKLSHGNATDLSHIDTNSTSEGFNTAE 61
+ V V+GS GGIGQPLSLLLK +P +S+L LYD+K + G DLSHI+T ++ F
Sbjct: 28 LKVAVVGSVGGIGQPLSLLLKHNPQISTLSLYDIKNTTGVGVDLSHINTRASVCPFEGKN 87
Query: 62 -IGQALKGAQLVIIPAGIPRKPGMSRDDLFKINAKIIKSLTVQIAEHAPDARILVISNPV 120
+ +A+ A +V+IPAG+PRKPGM R+DL +NA + + +E P A + I+NP+
Sbjct: 88 GLKKAMDKADIVVIPAGLPRKPGMKREDLVDVNASVACEVAFAASEVCPGAMLAFITNPI 147
Query: 121 NSLVPIVYETLQSMGKFQAGKVMGITTLDIIRSHTFLVDIIGRKAYSVEKLKDAVTVVGG 180
N +VPIV L++ G + ++ G+TTLD++R+ TF+ DI+ +V+ K + V+GG
Sbjct: 148 NVIVPIVATILKAKGTYDPNRLFGVTTLDVVRAQTFVADIL-----NVDPQKVNIPVIGG 202
Query: 181 HSGETIIPIFT--DQKFYRRLRDSNVYESYVHRVQFGGDEVVKAKDGSGSATLSMAWAGY 238
H+G TI+PI + D F ++ E+ + R+Q G EVV AKDG GSATLSMA+A
Sbjct: 203 HTGRTILPILSQCDPPFKGTDKER---EALIQRIQNAGTEVVNAKDGLGSATLSMAFAAT 259
Query: 239 TFAKKLLNSLHLNTAGDQHPIPTFVYLPGLPGGKELQKKLNTSVEFFSAPVKLEKGIVVA 298
F L+ + I Y+ + T +FF+ P+ L G
Sbjct: 260 QFVSSLIKGIK---GSKDECIVECAYV----------ESDVTEAQFFATPLIL--GPQGV 304
Query: 299 VEHEWVDKLNDDEKKLIAKCLPILEKNIKKGL 330
E+ + L+D+E+K + LPIL+++I KG+
Sbjct: 305 KENTGLPDLDDEERKALNGMLPILKESIAKGI 336
>7294521 [C] KOG1494 NAD-dependent malate dehydrogenase
Length = 349
Score = 204 bits (518), Expect = 2e-52
Identities = 132/336 (39%), Positives = 186/336 (55%), Gaps = 28/336 (8%)
Query: 2 VSVTVLGSSGGIGQPLSLLLKLDPHVSSLRLYDLKLSHGNATDLSHIDTNSTSEGFN-TA 60
+ V V+G+ GGIGQPLSLLL+ P + L L+DL G ATDLSHI GF
Sbjct: 23 LKVAVVGAGGGIGQPLSLLLRRCPGIDELALHDLSEMKGIATDLSHISQTGKVIGFTGEK 82
Query: 61 EIGQALKGAQLVIIPAGIPRKPGMSRDDLFKINAKIIKSLTVQIAEHAPDARILVISNPV 120
E+ A+ GA +V++ AG+PR PGM RD L N + + I+ +P A + I+NPV
Sbjct: 83 ELESAVSGADVVVVAAGMPRLPGMQRDHLMAANGNVAVKVATAISNASPRAHLAFITNPV 142
Query: 121 NSLVPIVYETLQSMGKFQAGKVMGITTLDIIRSHTFLVDIIGRKAYSVEKLKDAVTVVGG 180
N +VP E L + G F + ++ GITTLD++RS F+ D + V + V+GG
Sbjct: 143 NMIVPAAAEVLMAHGTFDSRRLFGITTLDVVRSKKFIGDSMNISPDDVN-----IPVIGG 197
Query: 181 HSGETIIPIFTD-QKFYRRLRDSNVYESYVHRVQFGGDEVVKAKDGSGSATLSMAWAGYT 239
H+G TI+P+ + Q YR D ++ HR+Q G EVV AK G GSATLSMA+AG T
Sbjct: 198 HAGITILPLISQCQPIYR--CDLQEIQNLTHRIQEAGTEVVNAKAGKGSATLSMAYAGAT 255
Query: 240 FAKKLLNSLHLNTAGDQHPIPTFVYLPGLPGGKELQKKLNTSVEFFSAPVKLEK-GIVVA 298
F LL + AG GL + KL T FF++P++L K GI
Sbjct: 256 FVNSLLRGI----AGQD----------GLIECAFVASKL-TDAPFFASPLELGKDGIKRY 300
Query: 299 VEHEWVDKLNDDEKKLIAKCLPILEKNIKKGLAFSK 334
+ + +++D EK+ + K LPIL +N +G+ F+K
Sbjct: 301 IP---LPQMSDYEKEALEKLLPILRQNADEGVNFAK 333
>SPAC186.08c [C] KOG1495 Lactate dehydrogenase
Length = 330
Score = 65.1 bits (157), Expect = 1e-10
Identities = 52/182 (28%), Positives = 86/182 (46%), Gaps = 12/182 (6%)
Query: 2 VSVTVLGSSGGIGQPLSLLLKLDPHVSSLRLYDL--KLSHGNATDLSHIDTNSTSEGFNT 59
+ + ++G+ G +G + L L + + + DL K + G A DL+H S
Sbjct: 21 IKIVIVGA-GNVGSTTAFTLLLSGLAAEIVIIDLNKKKAEGEAMDLNHAAPLSHETRVYL 79
Query: 60 AEIGQALKGAQLVIIPAGIPRKPGMSRDDLFKINAKIIKSLTVQIAEHAPDARILVISNP 119
+ K A V+I AG +KPG +R DL K N I K + ++ ++ DA +LV +NP
Sbjct: 80 GDYKDC-KDATAVVITAGKNQKPGETRMDLLKANISIFKEILREVTKYTKDAILLVATNP 138
Query: 120 VNSLVPIVYETLQSMGKFQAGKVMGITTLDIIRSHTFLVDIIGRKAYSVEKLKDAVTVVG 179
V+ L Y TL+ G F A +V+G T+ +L+ K Y ++ ++G
Sbjct: 139 VDVL---TYATLKLTG-FPAERVIGSGTIIDTARFQYLIG----KLYGLDPQSVNADIIG 190
Query: 180 GH 181
H
Sbjct: 191 EH 192
>Hs4504973 [C] KOG1495 Lactate dehydrogenase
Length = 332
Score = 59.7 bits (143), Expect = 6e-09
Identities = 86/356 (24%), Positives = 145/356 (40%), Gaps = 73/356 (20%)
Query: 4 VTVLGSSGGIGQPLSLLLKLDPHVSSLRLYDLKLSH--GNATDLSHIDTNSTSEGFNTAE 61
+T++G+ G +G ++ + L L L D+ L G DL H ++ + +
Sbjct: 23 ITIVGT-GAVGMACAISILLKDLADELALVDVALDKLKGEMMDLQHGSLFFSTSKITSGK 81
Query: 62 IGQALKGAQLVIIPAGIPRKPGMSRDDLFKINAKIIKSLTVQIAEHAPDARILVISNPVN 121
+++VI+ AG ++ G +R L + N I+KS+ I ++PD +ILV+SNPV+
Sbjct: 82 DYSVSANSRIVIVTAGARQQEGETRLALVQRNVAIMKSIIPAIVHYSPDCKILVVSNPVD 141
Query: 122 SLVPIVYETLQSMGKFQAGKVMGITTLDIIRSHTFLVD-----IIGRKAYSVEKLKDAVT 176
L IV+ K+ G+ +I S L +IG K V
Sbjct: 142 ILTYIVW------------KISGLPVTRVIGSGCNLDSARFRYLIGEK-LGVHPTSCHGW 188
Query: 177 VVGGHSGETIIPIF--------------------TDQKFYRRLRDSNVYESYVHRVQFGG 216
++G H G++ +P++ +D++ ++ + + +Y
Sbjct: 189 IIGEH-GDSSVPLWSGVNVAGVALKTLDPKLGTDSDKEHWKNIHKQVIQSAY-------- 239
Query: 217 DEVVKAKDGSGSATLSMAWAGYTFAKKLLNSLHLNTAGDQHPIPTFVYLPGLPGGKELQK 276
E++K K + +WA L+ S+ L HP+ T V GL G KE
Sbjct: 240 -EIIKLKGYT-------SWAIGLSVMDLVGSI-LKNLRRVHPVSTMV--KGLYGIKE--- 285
Query: 277 KLNTSVEFFSAPVKLEKGIVVAVEHEWVDKLNDDEKKLIAKCLPILEKNIKKGLAF 332
F S P L + V V LN +E+ L K L NI+K L F
Sbjct: 286 -----ELFLSIPCVLGRNGVSDVVK---INLNSEEEALFKKSAETL-WNIQKDLIF 332
>At4g17260 [C] KOG1495 Lactate dehydrogenase
Length = 353
Score = 59.3 bits (142), Expect = 8e-09
Identities = 80/342 (23%), Positives = 137/342 (39%), Gaps = 46/342 (13%)
Query: 4 VTVLGSSGGIGQPLSLLLKLDPHVSSLRLYDLKLS--HGNATDLSHIDTNSTSEGFNTAE 61
V+V+G G +G ++ + + L D K G DL H +
Sbjct: 43 VSVVGV-GNVGMAIAQTILTQDLADEIALVDAKPDKLRGEMLDLQHAAAFLPRTKITASV 101
Query: 62 IGQALKGAQLVIIPAGIPRKPGMSRDDLFKINAKIIKSLTVQIAEHAPDARILVISNPVN 121
+ G+ L I+ AG + PG SR +L + N + + + +A+ +PD+ ++++SNPV+
Sbjct: 102 DYEVTAGSDLCIVTAGARQNPGESRLNLLQRNVALFRHIIPPLAKASPDSILIIVSNPVD 161
Query: 122 SLVPIVYETLQSMGKFQAGKVMGI-TTLDIIRSHTFLVDIIGRKAYSVEKLKDAVTVVGG 180
L + ++ + F +V+G T LD R + D + A V+ +VG
Sbjct: 162 VLTYVAWK----LSGFPVNRVLGSGTNLDSSRFRFLIADHLDVNAQDVQAF-----IVGE 212
Query: 181 HSGETI----------IPIFTDQKFYRRLRDSNVYESYVHRVQFGGDEVVKAKDGSGSAT 230
H ++ IP+ + + + + E V EV+ K +
Sbjct: 213 HGDSSVALWSSISVGGIPVLSFLEKNQIAYEKQTLEDIHQAVVGSAYEVIGLKGYT---- 268
Query: 231 LSMAWA-GYTFAKKLLNSLHLNTAGDQHPI-PTFVYLPGLPGGKELQKKLNTSVEFFSAP 288
+WA GY+ A +L DQ I P V G G ++ F S P
Sbjct: 269 ---SWAIGYSVA-----NLARTILRDQRKIHPVTVLARGFYG-------VDGGDVFLSLP 313
Query: 289 VKLEKGIVVAVEHEWVDKLNDDEKKLIAKCLPILEKNIKKGL 330
L + VVAV + V +++ +KL ILE + GL
Sbjct: 314 ALLGRNGVVAVTN--VHMTDEEAEKLQKSAKTILEMQSQLGL 353
>At5g43330 [C] KOG1496 Malate dehydrogenase
Length = 332
Score = 55.5 bits (132), Expect = 1e-07
Identities = 62/245 (25%), Positives = 103/245 (41%), Gaps = 34/245 (13%)
Query: 2 VSVTVLGSSGGIGQPL------SLLLKLDPHVSSLRLYDLKLSHGNATDLSHIDTNSTSE 55
V V V G++G IG L ++L D V L + D+ + A L+ +
Sbjct: 6 VRVLVTGAAGQIGYALVPMIARGIMLGADQPVI-LHMLDIPFA---AEALNGVKMELVDA 61
Query: 56 GFN-------TAEIGQALKGAQLVIIPAGIPRKPGMSRDDLFKINAKIIKSLTVQIAEH- 107
F T + +A G + ++ G PRK GM R D+ N I KS + +H
Sbjct: 62 AFPLLKGVVATTDAVEACTGVNVAVMVGGFPRKEGMERKDVMSKNVSIYKSQASALEKHA 121
Query: 108 APDARILVISNPVNSLVPIVYETLQSMGKFQAGKVMGITTLDIIRSHTFLVDIIGRKAYS 167
AP+ ++LV++NP N+ I+ E S+ + IT L + + L + R +
Sbjct: 122 APNCKVLVVANPANTNALILKEFAPSIPE------KNITCLTRLDHNRALGQVSERLSVP 175
Query: 168 VEKLKDAVTVVGGHS-------GETIIPIFTDQKFYRRL--RDSNVYESYVHRVQFGGDE 218
V +K+ V + G HS + +K R L D + ++ VQ G
Sbjct: 176 VSDVKN-VIIWGNHSSTQYPDVNHATVKTSVGEKPVRELVKNDEWLNGEFISTVQQRGAA 234
Query: 219 VVKAK 223
++KA+
Sbjct: 235 IIKAR 239
>At5g56720 [C] KOG1496 Malate dehydrogenase
Length = 339
Score = 54.3 bits (129), Expect = 2e-07
Identities = 64/254 (25%), Positives = 105/254 (41%), Gaps = 42/254 (16%)
Query: 2 VSVTVLGSSGGIG----------------QPLSL-LLKLDPHVSSLRLYDLKLSHGNATD 44
+ V + G++G IG QP+ L LL ++P SSL ++L
Sbjct: 12 IRVLITGAAGNIGYAIAPMIARGIMLGPDQPMILHLLDIEPASSSLEAVKMELQDSAFPL 71
Query: 45 LSHIDTNSTSEGFNTAEIGQALKGAQLVIIPAGIPRKPGMSRDDLFKINAKIIKSLTVQI 104
L + T + +A K +VI+ G PR GM R D+ N I K+ +
Sbjct: 72 LKGV--------IATTNVVEACKDVNIVIMIGGFPRIAGMERKDVMSKNVVIYKAQASAL 123
Query: 105 AEHA-PDARILVISNPVNSLVPIVYETLQSMGKFQAGKVMGITTLDIIRSHTFLVDIIGR 163
+A D ++LV++NP N+ I+ E S+ + + +T LD R+ L D +
Sbjct: 124 ERYASDDCKVLVVANPANTNALILKEFAPSIPE---ENITCLTRLDHNRALAQLADKLSV 180
Query: 164 KAYSVEKLKDAVTVVGGHSG--------ETIIPIFTDQKFYRRLRDSN-VYESYVHRVQF 214
SV+ V V G HS T+ D+ + D N + ++ VQ
Sbjct: 181 PVSSVKN----VIVWGNHSSTQYPDTNHATVSTKTGDRPLKELVTDHNWLKNEFIVEVQQ 236
Query: 215 GGDEVVKAKDGSGS 228
G V++A+ S +
Sbjct: 237 RGAAVLRARKQSSA 250
>Hs22061164 [C] KOG1495 Lactate dehydrogenase
Length = 485
Score = 53.9 bits (128), Expect = 3e-07
Identities = 61/274 (22%), Positives = 115/274 (41%), Gaps = 31/274 (11%)
Query: 2 VSVTVLGSSGGIGQPLSLLLKLDPHVSSLRLYDLKLSHGNATDLSHIDTNSTSEGFNTAE 61
VS+T GS G LL L ++ + L + KL G DL H ++
Sbjct: 23 VSITGTGSVGMACATSILLKGLSDELAFVDLDEGKLK-GETMDLQHDSPFMKMSNIVCSK 81
Query: 62 IGQALKGAQLVIIPAGIPRKPGMSRDDLFKINAKIIKSLTVQIAEHAPDARILVISNPVN 121
LVII AG R+ G R +L + N I K + I + +P +++++SNPV+
Sbjct: 82 DYLVTANPHLVIITAGARREKGEMRFNLVRQNVAIFKLMISSIVQQSPLCKLIIVSNPVD 141
Query: 122 SLVPIVYETLQSMGKFQAGKVMGI-TTLDIIRSHTFLVDIIGRKAYSVEKLKDAVTVVGG 180
L + ++ + F +V+G LD +R F+ +G + S ++G
Sbjct: 142 ILTYVAWK----LSAFPKNRVIGSGCNLDTVRFQFFIGQKLGIHSESCRG-----WILGE 192
Query: 181 HSGETIIPIFTDQKFYRRL-----------RDSNVYESYVHRVQFGGDEVVKAKDGSGSA 229
H G++ +P+++ L +D +++ V E+++ K S
Sbjct: 193 H-GDSSVPVWSGMNIAGVLLKDLNSDIGTDKDPEKWKNVHKEVIASAYEIIEMK---SST 248
Query: 230 TLSMAWAGYTFAKKLLNSLHLNTAGDQHPIPTFV 263
+ ++ +G + +L +L +HP+ T +
Sbjct: 249 SWAIGLSGADLTESILKNLR-----RKHPVSTII 277
>At1g04410 [C] KOG1496 Malate dehydrogenase
Length = 332
Score = 53.1 bits (126), Expect = 6e-07
Identities = 47/175 (26%), Positives = 81/175 (45%), Gaps = 17/175 (9%)
Query: 59 TAEIGQALKGAQLVIIPAGIPRKPGMSRDDLFKINAKIIKSLTVQIAEH-APDARILVIS 117
T + + G + ++ G PRK GM R D+ N I KS + +H AP+ ++LV++
Sbjct: 72 TTDAVEGCTGVNVAVMVGGFPRKEGMERKDVMSKNVSIYKSQAAALEKHAAPNCKVLVVA 131
Query: 118 NPVNSLVPIVYETLQSMGKFQAGKVMGITTLDIIRSHTFLVDIIGRKAYSVEKLKDAVTV 177
NP N+ I+ E S+ + + +T LD R+ L I R + V +K+ V +
Sbjct: 132 NPANTNALILKEFAPSIPE---KNISCLTRLDHNRA---LGQISERLSVPVSDVKN-VII 184
Query: 178 VGGHSGETI-------IPIFTDQKFYRRL--RDSNVYESYVHRVQFGGDEVVKAK 223
G HS + + +K R L D+ + ++ VQ G ++KA+
Sbjct: 185 WGNHSSSQYPDVNHAKVQTSSGEKPVRELVKDDAWLDGEFISTVQQRGAAIIKAR 239
>Hs5031857 [C] KOG1495 Lactate dehydrogenase
Length = 332
Score = 52.4 bits (124), Expect = 9e-07
Identities = 48/192 (25%), Positives = 92/192 (47%), Gaps = 16/192 (8%)
Query: 4 VTVLGSSGGIGQPLSLLLKLDPHVSSLRLYDL---KLSHGNATDLSHIDTNSTSEGFNTA 60
+TV+G G +G ++ + + L L D+ KL G DL H + +
Sbjct: 23 ITVVGV-GAVGMACAISILMKDLADELALVDVIEDKLK-GEMMDLQHGSLFLRTPKIVSG 80
Query: 61 EIGQALKGAQLVIIPAGIPRKPGMSRDDLFKINAKIIKSLTVQIAEHAPDARILVISNPV 120
+ ++LVII AG ++ G SR +L + N I K + + +++P+ ++L++SNPV
Sbjct: 81 KDYNVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFIIPNVVKYSPNCKLLIVSNPV 140
Query: 121 NSLVPIVYETLQSMGKFQAGKVMGI-TTLDIIRSHTFLVDIIGRKAYSVEKLKDAVTVVG 179
+ L + ++ + F +V+G LD R + + +G V L V+G
Sbjct: 141 DILTYVAWK----ISGFPKNRVIGSGCNLDSARFRYLMGERLG-----VHPLSCHGWVLG 191
Query: 180 GHSGETIIPIFT 191
H G++ +P+++
Sbjct: 192 EH-GDSSVPVWS 202
>CE20820 [C] KOG1496 Malate dehydrogenase
Length = 336
Score = 52.4 bits (124), Expect = 9e-07
Identities = 50/197 (25%), Positives = 81/197 (40%), Gaps = 12/197 (6%)
Query: 65 ALKGAQLVIIPAGIPRKPGMSRDDLFKINAKIIKSLTVQIAEHA-PDARILVISNPVNSL 123
A G + +PR+ GM R DL N KI KS +AE+A P +++V+ NP N+
Sbjct: 77 AFTGIDYAFLVGAMPRREGMERKDLLAANVKIFKSQGKALAEYAKPTTKVIVVGNPANTN 136
Query: 124 VPIVYETLQSMGKFQAGKVMGITTLDIIRSHTFLVDIIGRKAYSVEKLKDAVTVVGGHSG 183
I + + GK A +T LD R+ L + + ++ +K+ V + G HSG
Sbjct: 137 AFIAAK--YAAGKIPAKNFSAMTRLDHNRA---LAQLALKTGTTIGNVKN-VIIWGNHSG 190
Query: 184 ETIIPIFTDQKFYRRLRDSNVYESYVHRVQFGGDEVVKAKDGSG----SATLSMAWAGYT 239
T P T + +++ Y + G + + G LS A +
Sbjct: 191 -TQFPDVTHATVNKNGTETDAYAAVGDNAFLQGPFIATVQKRGGVIIEKRKLSSAMSAAK 249
Query: 240 FAKKLLNSLHLNTAGDQ 256
A ++ H T Q
Sbjct: 250 AACDHIHDWHFGTKAGQ 266
>Hs5174539 [C] KOG1496 Malate dehydrogenase
Length = 334
Score = 51.2 bits (121), Expect = 2e-06
Identities = 46/181 (25%), Positives = 80/181 (43%), Gaps = 19/181 (10%)
Query: 65 ALKGAQLVIIPAGIPRKPGMSRDDLFKINAKIIKSLTVQIAEHA-PDARILVISNPVNSL 123
A K + I+ +PR+ GM R DL K N KI KS + ++A +++V+ NP N+
Sbjct: 77 AFKDLDVAILVGSMPRREGMERKDLLKANVKIFKSQGAALDKYAKKSVKVIVVGNPANTN 136
Query: 124 VPIVYETLQSMGKFQAGKVMGITTLDIIRSHTFLVDIIGRKAYSVEKLKDAVTVVGGHSG 183
++ S+ K +T LD R+ + +G A V+ + ++ G+
Sbjct: 137 CLTASKSAPSIPK---ENFSCLTRLDHNRAKAQIALKLGVTANDVKNV-----IIWGNHS 188
Query: 184 ETIIPIFTDQKFYRRLRDSNVYES----------YVHRVQFGGDEVVKAKDGSGSATLSM 233
T P K + ++ VYE+ +V VQ G V+KA+ S + + +
Sbjct: 189 STQYPDVNHAKVKLQGKEVGVYEALKDDSWLKGEFVTTVQQRGAAVIKARKLSSAMSAAK 248
Query: 234 A 234
A
Sbjct: 249 A 249
>Hs15082234 [C] KOG1495 Lactate dehydrogenase
Length = 381
Score = 49.7 bits (117), Expect = 6e-06
Identities = 46/191 (24%), Positives = 94/191 (49%), Gaps = 14/191 (7%)
Query: 4 VTVLGS-SGGIGQPLSLLLK-LDPHVSSLRLYDLKLSHGNATDLSHIDTNSTSEGFNTAE 61
V+++G+ S G+ +S+LLK L ++ + L + KL G DL H + ++
Sbjct: 72 VSIIGTGSVGMACAISILLKGLSDELALVDLDEDKLK-GETMDLQHGSPFTKMPNIVCSK 130
Query: 62 IGQALKGAQLVIIPAGIPRKPGMSRDDLFKINAKIIKSLTVQIAEHAPDARILVISNPVN 121
+ LVII AG ++ G +R +L + N I K + I +++P +++++SNPV+
Sbjct: 131 DYFVTANSNLVIITAGARQEKGETRLNLVQRNVAIFKLMISSIVQYSPHCKLIIVSNPVD 190
Query: 122 SLVPIVYETLQSMGKFQAGKVMGI-TTLDIIRSHTFLVDIIGRKAYSVEKLKDAVTVVGG 180
L + ++ + F +++G LD R + +G + S ++G
Sbjct: 191 ILTYVAWK----LSAFPKNRIIGSGCNLDTARFRFLIGQKLGIHSESCHG-----WILGE 241
Query: 181 HSGETIIPIFT 191
H G++ +P+++
Sbjct: 242 H-GDSSVPVWS 251
>7295348 [C] KOG1495 Lactate dehydrogenase
Length = 332
Score = 49.7 bits (117), Expect = 6e-06
Identities = 41/166 (24%), Positives = 78/166 (46%), Gaps = 12/166 (7%)
Query: 40 GNATDLSHIDTNSTSEGFNTAEIGQALKGAQLVIIPAGIPRKPGMSRDDLFKINAKIIKS 99
G DL H + + A ++L I+ AG+ +K G SR L + N I+K+
Sbjct: 60 GELMDLQHGSNFLKNPQITASTDFAASANSRLCIVTAGVRQKEGESRLSLVQRNTDILKN 119
Query: 100 LTVQIAEHAPDARILVISNPVNSLVPIVYETLQSMGKFQAGKVMGI-TTLDIIRSHTFLV 158
+ ++ E++PD +L++SNPV+ + + ++ + +V+G T LD R +
Sbjct: 120 IIPKLVEYSPDTILLMVSNPVDIMTYVAWK----LSGLPKNRVIGSGTNLDSSRFRFLMS 175
Query: 159 DIIGRKAYSVEKLKDAVTVVGGHSGETIIPIFTDQKFYR-RLRDSN 203
+G S ++G H G++ +P+++ RLR+ N
Sbjct: 176 QRLGVAPTSCHG-----WIIGEH-GDSSVPVWSGVNIAGVRLRELN 215
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.317 0.136 0.384
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,810,807
Number of Sequences: 60738
Number of extensions: 856433
Number of successful extensions: 2193
Number of sequences better than 1.0e-05: 27
Number of HSP's better than 0.0 without gapping: 15
Number of HSP's successfully gapped in prelim test: 12
Number of HSP's that attempted gapping in prelim test: 2112
Number of HSP's gapped (non-prelim): 28
length of query: 338
length of database: 30,389,216
effective HSP length: 107
effective length of query: 231
effective length of database: 23,890,250
effective search space: 5518647750
effective search space used: 5518647750
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)