ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactVI4916 good H KOG1518 Coenzyme transport and metabolism Coproporphyrinogen III oxidase CPO/HEM13
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactVI4916 1706744 1707868 375
(375 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YDR044w [H] KOG1518 Coproporphyrinogen III oxidase CPO/HEM13 520 e-147
SPAC222.11 [H] KOG1518 Coproporphyrinogen III oxidase CPO/HEM13 325 7e-89
7297203 [H] KOG1518 Coproporphyrinogen III oxidase CPO/HEM13 315 9e-86
Hs20127406 [H] KOG1518 Coproporphyrinogen III oxidase CPO/HEM13 309 5e-84
At1g03475 [H] KOG1518 Coproporphyrinogen III oxidase CPO/HEM13 280 2e-75
>YDR044w [H] KOG1518 Coproporphyrinogen III oxidase CPO/HEM13
Length = 328
Score = 520 bits (1340), Expect = e-147
Identities = 243/318 (76%), Positives = 269/318 (84%)
Query: 58 VPIRERMEALVRRKQQEITKGLETLDTVKFQADSWDRGNNGGGGVSMVLQNGTTFEKGGV 117
+PIR++MEAL+RRKQ EIT+GLE++DTVKF AD+W RGN+GGGG SMV+Q+GTTFEKGGV
Sbjct: 10 LPIRQQMEALIRRKQAEITQGLESIDTVKFHADTWTRGNDGGGGTSMVIQDGTTFEKGGV 69
Query: 118 NVSVVHGNLSPPAIKAMKADHKNLHLPIDPATGEPDATGVKFFACGLSMVIHPINPHAPT 177
NVSVV+G LSP A+ AMKADHKNL LP DP TG P GVKFFACGLSMVIHP+NPHAPT
Sbjct: 70 NVSVVYGQLSPAAVSAMKADHKNLRLPEDPKTGLPVTDGVKFFACGLSMVIHPVNPHAPT 129
Query: 178 THLNYRYFETWNADGTPQAWWFGGGADLTPSYLYEEDAKLFHQLHKDALDKTDVALYPKY 237
THLNYRYFETWN DGTPQ WWFGGGADLTPSYLYEED +LFHQLHKDALDK D ALYP++
Sbjct: 130 THLNYRYFETWNQDGTPQTWWFGGGADLTPSYLYEEDGQLFHQLHKDALDKHDTALYPRF 189
Query: 238 KKWCDEYFYIKHREETXXXXXXXXXXXXXXXPNEILQMVENCFDAFLPSYLEIIKRRKDM 297
KKWCDEYFYI HR+ET P EIL+MVE+CFDAFLPSYL I+KRRKDM
Sbjct: 190 KKWCDEYFYITHRKETRGIGGIFFDDYDERDPQEILKMVEDCFDAFLPSYLTIVKRRKDM 249
Query: 298 PYTEEERQWQQIRRGRYVEFNLVLDRGTQFGLRTPGSRVESILMSLPVTASWLYDHHPEV 357
PYT+EE+QWQ IRRGRYVEFNL+ DRGTQFGLRTPGSRVESILMSLP ASWLY+HHP
Sbjct: 250 PYTKEEQQWQAIRRGRYVEFNLIYDRGTQFGLRTPGSRVESILMSLPEHASWLYNHHPAP 309
Query: 358 DSREDKLLQVLKNPVEWV 375
SRE KLL+V P EWV
Sbjct: 310 GSREAKLLEVTTKPREWV 327
>SPAC222.11 [H] KOG1518 Coproporphyrinogen III oxidase CPO/HEM13
Length = 312
Score = 325 bits (833), Expect = 7e-89
Identities = 163/323 (50%), Positives = 216/323 (66%), Gaps = 13/323 (4%)
Query: 53 MTDSQV-PIRERMEALVRRKQQEITKGLETLDTVKFQADSWDRGNNGGGGVSMVLQNGTT 111
M+D V PI ++ME L+ QQEI GLE +D KF D W +G GG G+S V+Q+G
Sbjct: 1 MSDITVEPIGKQMEKLILDVQQEIVAGLEAVDGQKFFQDKWTKGE-GGYGISCVIQDGNV 59
Query: 112 FEKGGVNVSVVHGNLSPPAIKAMKADHKNLHLPIDPATGEPDATGVKFFACGLSMVIHPI 171
FEKGGVN S+V G L+ A++ M+A+H+ + + A + FFA G+SMVIHP
Sbjct: 60 FEKGGVNTSIVQGKLNQDAVQRMRANHEGI---------DRTAKELPFFAAGISMVIHPR 110
Query: 172 NPHAPTTHLNYRYFETWNADGTPQAWWFGGGADLTPSYLYEEDAKLFHQLHKDALDKTDV 231
NP APTTHLNYRYFE N+DG + WWFGGGADLTPS L+EED K FH+LHK+A D+ D
Sbjct: 111 NPMAPTTHLNYRYFELVNSDGK-KIWWFGGGADLTPSILFEEDGKHFHKLHKEACDRHDP 169
Query: 232 ALYPKYKKWCDEYFYIKHREETXXXXXXXXXXXXXXXPNEILQMVENCFDAFLPSYLEII 291
YP++KKW DEYF IKHR+ET P E+ V++C FLP+Y+ I+
Sbjct: 170 TFYPRFKKWADEYFLIKHRKETRGIGGIFFDDLSEKDPQELFAFVKDCAHTFLPAYVPIM 229
Query: 292 KRRKDMPYTEEERQWQQIRRGRYVEFNLVLDRGTQFGLRTPGSRVESILMSLPVTASWLY 351
++RK+M +TE+++++Q IRRG Y EFN++ DRGT FGL+ P RVESILM+LP+ ASW Y
Sbjct: 230 EKRKNMEFTEDDKEFQLIRRGYYAEFNVMYDRGTWFGLQAPEPRVESILMTLPLHASWRY 289
Query: 352 DHHPEVDSREDKLLQVLKNPVEW 374
+ P+ R LL+V P+EW
Sbjct: 290 KYEPK-QERHKALLKVTHTPIEW 311
>7297203 [H] KOG1518 Coproporphyrinogen III oxidase CPO/HEM13
Length = 390
Score = 315 bits (806), Expect = 9e-86
Identities = 165/344 (47%), Positives = 210/344 (60%), Gaps = 21/344 (6%)
Query: 40 VHLNTHSKYYHCAMTDSQVPI------RERMEALVRRKQQEITKGLETLDTV--KFQADS 91
V +NT S++ +TDS+ + R RME L+ Q E + LE + KF+ D
Sbjct: 60 VQMNT-SRFMAEPITDSKALLGDKENMRHRMEILIMEIQAEFCRALEAEENCGQKFKVDR 118
Query: 92 WDRGNNGGGGVSMVLQNGTTFEKGGVNVSVVHGNLSPPAIKAMKADHKNLHLPIDPATGE 151
W+R GGGG++ VLQ+G FEK GVN+SVV G+L P A++ M+A KNL
Sbjct: 119 WERPE-GGGGITCVLQDGDVFEKAGVNISVVTGSLPPAAVQQMRARGKNLK--------- 168
Query: 152 PDATGVKFFACGLSMVIHPINPHAPTTHLNYRYFETWNADGTPQAWWFGGGADLTPSYLY 211
+ + FFA G+S VIHP NPH PT H NYRYFE A G Q WWFGGG DLTP YL
Sbjct: 169 -EGASLPFFASGVSAVIHPRNPHVPTIHFNYRYFEVETAKGEKQ-WWFGGGTDLTPYYLC 226
Query: 212 EEDAKLFHQLHKDALDKTDVALYPKYKKWCDEYFYIKHREETXXXXXXXXXXXXXXXPNE 271
E+DA FHQ K A D+ D YP++KKWCD+YF IKHR E+
Sbjct: 227 EKDASHFHQTLKSACDEHDPTYYPRFKKWCDDYFRIKHRNESRGIGGIFFDDIDSPNQEA 286
Query: 272 ILQMVENCFDAFLPSYLEIIKRRKDMPYTEEERQWQQIRRGRYVEFNLVLDRGTQFGLRT 331
V +C A +PSY+ ++++ K+ Y ERQWQ +RRGRYVEFNL+ DRGT+FGL T
Sbjct: 287 AFNFVSSCARAVIPSYVPLVRKHKNREYGNNERQWQLLRRGRYVEFNLIYDRGTKFGLYT 346
Query: 332 PGSRVESILMSLPVTASWLYDHHPEVDSREDKLLQVLKNPVEWV 375
PG+R ESILMSLP+ A W Y H P+ S E KL++VLKNP +WV
Sbjct: 347 PGARYESILMSLPLHARWEYMHEPKSQSEEGKLMKVLKNPKDWV 390
>Hs20127406 [H] KOG1518 Coproporphyrinogen III oxidase CPO/HEM13
Length = 454
Score = 309 bits (791), Expect = 5e-84
Identities = 155/317 (48%), Positives = 206/317 (64%), Gaps = 12/317 (3%)
Query: 60 IRERMEALVRRKQQEITKGLETLDT-VKFQADSWDRGNNGGGGVSMVLQNGTTFEKGGVN 118
++ +ME L+ Q ++ + L +D F D W+R GGGG+S VLQ+G FEK GV+
Sbjct: 148 MKTKMELLILETQAQVCQALAQVDGGANFSVDRWER-KEGGGGISCVLQDGCVFEKAGVS 206
Query: 119 VSVVHGNLSPPAIKAMKADHKNLHLPIDPATGEPDATGVKFFACGLSMVIHPINPHAPTT 178
+SVVHGNLS A K M++ K L + + F A G+S VIHP NPHAPT
Sbjct: 207 ISVVHGNLSEEAAKQMRSRGKVL---------KTKDGKLPFCAMGVSSVIHPKNPHAPTI 257
Query: 179 HLNYRYFETWNADGTPQAWWFGGGADLTPSYLYEEDAKLFHQLHKDALDKTDVALYPKYK 238
H NYRYFE ADG Q WWFGGG DLTP+YL +EDA FH+ K+A D+ LYPK+K
Sbjct: 258 HFNYRYFEVEEADGHKQ-WWFGGGCDLTPTYLNQEDAVHFHRTLKEACDQHGPDLYPKFK 316
Query: 239 KWCDEYFYIKHREETXXXXXXXXXXXXXXXPNEILQMVENCFDAFLPSYLEIIKRRKDMP 298
KWCD+YF+I HR E E+ + V++C A +PSY+ ++K+ D
Sbjct: 317 KWCDDYFFIAHRGERRGIGGIFFDDLDSPSKEEVFRFVQSCARAVVPSYIPLVKKHCDDS 376
Query: 299 YTEEERQWQQIRRGRYVEFNLVLDRGTQFGLRTPGSRVESILMSLPVTASWLYDHHPEVD 358
+T +E+ WQQ+RRGRYVEFNL+ DRGT+FGL TPGSR+ESILMSLP+TA W Y H P +
Sbjct: 377 FTPQEKLWQQLRRGRYVEFNLLYDRGTKFGLFTPGSRIESILMSLPLTARWEYMHSPSEN 436
Query: 359 SREDKLLQVLKNPVEWV 375
S+E ++L+VL++P +WV
Sbjct: 437 SKEAEILEVLRHPRDWV 453
>At1g03475 [H] KOG1518 Coproporphyrinogen III oxidase CPO/HEM13
Length = 362
Score = 280 bits (717), Expect = 2e-75
Identities = 143/314 (45%), Positives = 189/314 (59%), Gaps = 19/314 (6%)
Query: 35 ETQRPVHLNTHSKYYHCAMTDSQVPIRERMEALVRRKQQEITKGLETLDT-VKFQADSWD 93
ET+RP S + S +R R E ++R Q + +E ++ KF+ D W
Sbjct: 57 ETERPFTFLRDSD--DVTPSSSSSSVRARFETMIRAAQDSVCDAIEAIEGGPKFKEDVWS 114
Query: 94 RGNNGGGGVSMVLQNGTTFEKGGVNVSVVHGNLSPPAIKAMKADHKNLHLPIDPATGEPD 153
R GGGG+S VLQ+G FEK GVNVSVV+G + P A +A K + +
Sbjct: 115 RPG-GGGGISRVLQDGNVFEKAGVNVSVVYGVMPPEAYRAAKG-----------SASDQK 162
Query: 154 ATGVKFFACGLSMVIHPINPHAPTTHLNYRYFET---WNADGTPQAWWFGGGADLTPSYL 210
V FFA G+S V+HP NP APT H NYRYFET + G P+ WWFGGG D TP+Y+
Sbjct: 163 PGPVPFFAAGVSSVLHPKNPFAPTLHFNYRYFETDAPKDVPGAPRQWWFGGGTDFTPAYI 222
Query: 211 YEEDAKLFHQLHKDALDKTDVALYPKYKKWCDEYFYIKHREETXXXXXXXXXXXXXXXPN 270
+EED K FH + K A DK D + YP++KKWCD+YFYIKHR+E
Sbjct: 223 FEEDVKHFHSIQKQACDKFDPSFYPRFKKWCDDYFYIKHRDERRGLGGIFFDDLNDYDQE 282
Query: 271 EILQMVENCFDAFLPSYLEIIKRRKDMPYTEEERQWQQIRRGRYVEFNLVLDRGTQFGLR 330
+L C ++ +P+Y+ I+++RKDM +TE+ + WQQ+RRGRYVEFNLV DRGT FGL+
Sbjct: 283 MLLSFATECANSVVPAYIPIVEKRKDMEFTEQHKAWQQLRRGRYVEFNLVYDRGTTFGLK 342
Query: 331 TPGSRVESILMSLP 344
T G R+ESIL+SLP
Sbjct: 343 T-GGRIESILVSLP 355
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.319 0.136 0.426
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,777,379
Number of Sequences: 60738
Number of extensions: 1041052
Number of successful extensions: 2428
Number of sequences better than 1.0e-05: 5
Number of HSP's better than 0.0 without gapping: 5
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 2407
Number of HSP's gapped (non-prelim): 5
length of query: 375
length of database: 30,389,216
effective HSP length: 108
effective length of query: 267
effective length of database: 23,829,512
effective search space: 6362479704
effective search space used: 6362479704
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)