ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactVI5289 good Z KOG0046 Cytoskeleton Ca2+-binding actin-bundling protein (fimbrin/plastin), EF-Hand protein superfamily
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactVI5289 1833700 1831730 -657
(657 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YDR129c [Z] KOG0046 Ca2+-binding actin-bundling protein (fimbrin... 1016 0.0
SPBC1778.06c [Z] KOG0046 Ca2+-binding actin-bundling protein (fi... 766 0.0
7293343 [Z] KOG0046 Ca2+-binding actin-bundling protein (fimbrin... 446 e-125
Hs7549809 [Z] KOG0046 Ca2+-binding actin-bundling protein (fimbr... 434 e-121
At2g04750 [Z] KOG0046 Ca2+-binding actin-bundling protein (fimbr... 432 e-121
At5g55400 [Z] KOG0046 Ca2+-binding actin-bundling protein (fimbr... 432 e-120
At5g35700 [Z] KOG0046 Ca2+-binding actin-bundling protein (fimbr... 432 e-120
Hs4505897 [Z] KOG0046 Ca2+-binding actin-bundling protein (fimbr... 431 e-120
Hs4504965 [Z] KOG0046 Ca2+-binding actin-bundling protein (fimbr... 424 e-118
At4g26700 [Z] KOG0046 Ca2+-binding actin-bundling protein (fimbr... 414 e-115
At5g48460 [Z] KOG0046 Ca2+-binding actin-bundling protein (fimbr... 410 e-114
CE27452 [Z] KOG0046 Ca2+-binding actin-bundling protein (fimbrin... 159 2e-38
CE26481 [Z] KOG0046 Ca2+-binding actin-bundling protein (fimbrin... 130 5e-30
CE26598_2 [Z] KOG0046 Ca2+-binding actin-bundling protein (fimbr... 129 1e-29
SPAC15A10.08 [Z] KOG0035 Ca2+-binding actin-bundling protein (ac... 80 8e-15
Hs15011908 [Z] KOG0516 Dystonin GAS (Growth-arrest-specific prot... 76 2e-13
Hs15011904 [Z] KOG0516 Dystonin GAS (Growth-arrest-specific prot... 76 2e-13
Hs5032283 [NTZ] KOG4286 Dystrophin-like protein 75 4e-13
Hs5032281 [NTZ] KOG4286 Dystrophin-like protein 72 3e-12
Hs5032287 [NTZ] KOG4286 Dystrophin-like protein 72 3e-12
Hs4505877 [Z] KOG0516 Dystonin GAS (Growth-arrest-specific prote... 70 1e-11
Hs6005938 [NTZ] KOG4286 Dystrophin-like protein 68 4e-11
Hs4501893 [Z] KOG0035 Ca2+-binding actin-bundling protein (actin... 67 9e-11
CE21256 [Z] KOG0035 Ca2+-binding actin-bundling protein (actinin... 66 2e-10
CE06539 [Z] KOG0035 Ca2+-binding actin-bundling protein (actinin... 66 2e-10
CE25734 [Z] KOG0516 Dystonin GAS (Growth-arrest-specific protein... 64 6e-10
7303255 [Z] KOG0516 Dystonin GAS (Growth-arrest-specific protein... 64 7e-10
CE25957 [Z] KOG0516 Dystonin GAS (Growth-arrest-specific protein... 64 1e-09
Hs5902122 [Z] KOG0517 Beta-spectrin 62 3e-09
Hs4557241 [Z] KOG0035 Ca2+-binding actin-bundling protein (actin... 62 3e-09
CE27773 [Z] KOG0517 Beta-spectrin 62 3e-09
7290243 [Z] KOG0035 Ca2+-binding actin-bundling protein (actinin... 62 3e-09
Hs13435161 [Z] KOG0517 Beta-spectrin 61 5e-09
Hs4507193 [Z] KOG0517 Beta-spectrin 61 6e-09
Hs4501891 [Z] KOG0035 Ca2+-binding actin-bundling protein (actin... 60 1e-08
Hs19923599 [Z] KOG0516 Dystonin GAS (Growth-arrest-specific prot... 59 2e-08
ECU09g0290 [Z] KOG0035 Ca2+-binding actin-bundling protein (acti... 59 2e-08
Hs12025678 [Z] KOG0035 Ca2+-binding actin-bundling protein (acti... 59 3e-08
Hs4507195 [Z] KOG0517 Beta-spectrin 58 4e-08
Hs21553341 [Z] KOG0516 Dystonin GAS (Growth-arrest-specific prot... 58 4e-08
7292359 [Z] KOG0517 Beta-spectrin 58 5e-08
7291470 [Z] KOG0518 Actin-binding cytoskeleton protein filamin 56 2e-07
CE28605 [Z] KOG0517 Beta-spectrin 54 6e-07
CE28604 [Z] KOG0517 Beta-spectrin 54 6e-07
7300519 [NTZ] KOG4286 Dystrophin-like protein 54 8e-07
Hs4503745 [Z] KOG0518 Actin-binding cytoskeleton protein filamin 53 2e-06
7293373 [Z] KOG0517 Beta-spectrin 52 2e-06
CE04046 [Z] KOG0518 Actin-binding cytoskeleton protein filamin 52 4e-06
Hs4557597 [Z] KOG0518 Actin-binding cytoskeleton protein filamin 51 6e-06
CE18188 [Z] KOG0516 Dystonin GAS (Growth-arrest-specific protein... 50 8e-06
>YDR129c [Z] KOG0046 Ca2+-binding actin-bundling protein (fimbrin/plastin)
EF-Hand protein superfamily
Length = 642
Score = 1016 bits (2628), Expect = 0.0
Identities = 514/658 (78%), Positives = 577/658 (87%), Gaps = 17/658 (2%)
Query: 1 MNIIRLQRKFPEFSQEDLFETIEHFRNIDLEDKGWVEKPQILESISKSGVASYDEARETL 60
MNI++LQRKFP +QEDLF TIE FR IDL+DKGWVEK Q LE++SK G A+YDEARETL
Sbjct: 1 MNIVKLQRKFPILTQEDLFSTIEKFRAIDLDDKGWVEKQQALEAVSKDGDATYDEARETL 60
Query: 61 KTVDVDASGHVELEDYVELMAKLRANGSSQGTQQDEDNSKGFPQTSFPNISGQSNRAPPV 120
K V VDASG VEL+DYV L+AKLR E + PQT+F N++ N P V
Sbjct: 61 KHVGVDASGRVELDDYVGLVAKLR-----------ESKTGAAPQTTF-NVA--PNSTPIV 106
Query: 121 PTKPKSIGLQHKGTGEKAQIIVGGSTSGTTHTINEEERRAFTTHINSVLAGDADIGHRLP 180
T + GLQHKG G +A+IIV GS +GTTHTINEEERR FT HINSVLAGD DIG LP
Sbjct: 107 STA--ATGLQHKGKGTQAKIIVAGSQTGTTHTINEEERREFTKHINSVLAGDQDIGDLLP 164
Query: 181 FPTDTFQLFDECRDGLVLSKLINDSVPDTIDTRVLNWPKNNKALNTFTASENANIVINSA 240
FPTDTFQLFDECRDGLVLSKLINDSVPDTIDTRVLNWPK K LN F ASENANIVINSA
Sbjct: 165 FPTDTFQLFDECRDGLVLSKLINDSVPDTIDTRVLNWPKKGKELNNFQASENANIVINSA 224
Query: 241 KAIGCVVVNVHSEDIIEGKEHLILGLIWQIIRRGLLSKIDIKLHPELYRLLEEDETLEQF 300
KAIGCVVVNVHSEDIIEG+EHLILGLIWQIIRRGLLSKIDIKLHPELYRLLE+DETLEQF
Sbjct: 225 KAIGCVVVNVHSEDIIEGREHLILGLIWQIIRRGLLSKIDIKLHPELYRLLEDDETLEQF 284
Query: 301 LRLPPEQILLRWFNYHLKQAGWHRRVSNFSSDIKDGENYTVLLNQLDSNLCSLGPLQTTD 360
LRLPPEQILLRWFNYHLKQA W+RRV+NFS D+ DGENYT+LLNQLD LCS PLQTTD
Sbjct: 285 LRLPPEQILLRWFNYHLKQANWNRRVTNFSKDVSDGENYTILLNQLDPALCSKAPLQTTD 344
Query: 361 LLERAEEVLQNAEKLECRKYLTPTALVAGNPKLNLAFVAHLFNTHPGLDPLDENEPIEIE 420
L+ERAE+VLQNAEKL+CRKYLTP++LVAGNPKLNLAFVAHLFNTHPGL+P+ E E EIE
Sbjct: 345 LMERAEQVLQNAEKLDCRKYLTPSSLVAGNPKLNLAFVAHLFNTHPGLEPIQEEEKPEIE 404
Query: 421 DFDAEGEREARVFTLWLNSLEVDPPVVSLFEDLKDGLVLLQAYDKVIPGSVNWKVINKK- 479
+FDAEGEREARVFTLWLNSL+VDPPV+SLF+DLKDGL+LLQAY+KV+PG+V++K +NK+
Sbjct: 405 EFDAEGEREARVFTLWLNSLDVDPPVISLFDDLKDGLILLQAYEKVMPGAVDFKHVNKRP 464
Query: 480 SSDSELSRFKALENTNYAVDLGKSRGFSLVGIDGSDIVDGNKLLTLGLVWQLMRKNIVNT 539
+S +E+SRFKALENTNYAVDLG+++GFSLVGI+GSDIVDGNKLLTLGLVWQLMR+NI T
Sbjct: 465 ASGAEISRFKALENTNYAVDLGRAKGFSLVGIEGSDIVDGNKLLTLGLVWQLMRRNISIT 524
Query: 540 MNELATTGRDMSDSQILKWAQETVSKGGKSSTIRSFSDPSLSNAHFLLDVLNGLAPGYVD 599
M L+++GRDMSDSQILKWAQ+ V+KGGK+STIRSF D +LSNAHFLLDVLNG+APGYVD
Sbjct: 525 MKTLSSSGRDMSDSQILKWAQDQVTKGGKNSTIRSFKDQALSNAHFLLDVLNGIAPGYVD 584
Query: 600 YSLVLPGKTEEDRYANARLAISIARKLGALIWLVPEDINEVRSRLILTFVASLMALKR 657
Y LV PG TEE+RYANARLAISIARKLGALIWLVPEDINEVR+RLI+TF+ASLM L +
Sbjct: 585 YDLVTPGNTEEERYANARLAISIARKLGALIWLVPEDINEVRARLIITFIASLMTLNK 642
>SPBC1778.06c [Z] KOG0046 Ca2+-binding actin-bundling protein (fimbrin/plastin)
EF-Hand protein superfamily
Length = 614
Score = 766 bits (1977), Expect = 0.0
Identities = 388/657 (59%), Positives = 483/657 (73%), Gaps = 45/657 (6%)
Query: 1 MNIIRLQRKFPEFSQEDLFETIEHFRNIDLEDKGWVEKPQILESISKSGVASYDEARETL 60
M ++LQ+K+PE + E++ + F +D++ KG++++P +++ S SYDE RE +
Sbjct: 1 MLALKLQKKYPELTNEEILTLTDQFNKLDVDGKGYLDQPTTIKAFEDSKKGSYDEVREAI 60
Query: 61 KTVDVDASGHVELEDYVELMAKLRANGSSQGTQQDEDNSKGFPQTSFPNISGQSNRAPPV 120
+ V+VD+SG VE ED+V + L+ KG T
Sbjct: 61 REVNVDSSGRVEPEDFVGIFNVLK---------------KGVEGTEV------------- 92
Query: 121 PTKPKSIGLQHKGTGEKAQIIVGGSTSGTTHTINEEERRAFTTHINSVLAGDADIGHRLP 180
+K +I + GS+S +HTINEEERR F HINSVLAGD D+G R+P
Sbjct: 93 ---------------KKGRITIKGSSSSVSHTINEEERREFIKHINSVLAGDPDVGSRVP 137
Query: 181 FPTDTFQLFDECRDGLVLSKLINDSVPDTIDTRVLNWPKNNKALNTFTASENANIVINSA 240
T+TF+ FD+C+DGL+LSKLINDSVPDTID RVLN +NNK L+ F EN N+VINSA
Sbjct: 138 INTETFEFFDQCKDGLILSKLINDSVPDTIDERVLNKQRNNKPLDNFKCIENNNVVINSA 197
Query: 241 KAIGCV-VVNVHSEDIIEGKEHLILGLIWQIIRRGLLSKIDIKLHPELYRLLEEDETLEQ 299
KA+G + + N+ + DI+EG+EHLILGL+WQIIRRGLL KIDI LHPELYRLLEEDETL+Q
Sbjct: 198 KAMGGISITNIGAGDILEGREHLILGLVWQIIRRGLLGKIDITLHPELYRLLEEDETLDQ 257
Query: 300 FLRLPPEQILLRWFNYHLKQAGWHRRVSNFSSDIKDGENYTVLLNQLDSNLCSLGPLQTT 359
FLRLPPE+ILLRWFNYHLK A W R VSNFS D+ DGENYTVLLNQL LCS PLQTT
Sbjct: 258 FLRLPPEKILLRWFNYHLKAANWPRTVSNFSKDVSDGENYTVLLNQLAPELCSRAPLQTT 317
Query: 360 DLLERAEEVLQNAEKLECRKYLTPTALVAGNPKLNLAFVAHLFNTHPGLDPLDENEPIEI 419
D+L+RAE+VLQNAEKL+CRKYLTPTA+VAGNPKLNLAFVAHLFNTHPGL+PL+E E EI
Sbjct: 318 DVLQRAEQVLQNAEKLDCRKYLTPTAMVAGNPKLNLAFVAHLFNTHPGLEPLNEEEKPEI 377
Query: 420 EDFDAEGEREARVFTLWLNSLEVDPPVVSLFEDLKDGLVLLQAYDKVIPGSVNWKVINK- 478
E FDAEGEREARVFTLWLNSL+V P + F +L+DGL+LLQAYDK+ P +VNWK +NK
Sbjct: 378 EPFDAEGEREARVFTLWLNSLDVTPSIHDFFNNLRDGLILLQAYDKITPNTVNWKKVNKA 437
Query: 479 KSSDSELSRFKALENTNYAVDLGKSRGFSLVGIDGSDIVDGNKLLTLGLVWQLMRKNIVN 538
+S E+ RFKA+EN NYAVDLGK++GFSLVGI G+DI DG++ LTL LVWQ+MR NI
Sbjct: 438 PASGDEMMRFKAVENCNYAVDLGKNQGFSLVGIQGADITDGSRTLTLALVWQMMRMNITK 497
Query: 539 TMNELATTGRDMSDSQILKWAQETVSKGGKSSTIRSFSDPSLSNAHFLLDVLNGLAPGYV 598
T++ L+ G+ +SDS ++ WA +KGGK S IRSF DPS+S F+LDVL+G+ YV
Sbjct: 498 TLHSLSRGGKTLSDSDMVAWANSMAAKGGKGSQIRSFRDPSISTGVFVLDVLHGIKSEYV 557
Query: 599 DYSLVLPGKTEEDRYANARLAISIARKLGALIWLVPEDINEVRSRLILTFVASLMAL 655
DY+LV G TEE NARLAISIARKLGA+I+++PEDI VR RL+L F+ SLMA+
Sbjct: 558 DYNLVTDGSTEELAIQNARLAISIARKLGAVIFILPEDIVAVRPRLVLHFIGSLMAV 614
>7293343 [Z] KOG0046 Ca2+-binding actin-bundling protein (fimbrin/plastin)
EF-Hand protein superfamily
Length = 640
Score = 446 bits (1146), Expect = e-125
Identities = 250/611 (40%), Positives = 375/611 (60%), Gaps = 20/611 (3%)
Query: 55 EARETLKTVDVDASGHVELEDYVELMAKLRANGSSQGTQQDEDNSKGFPQTSFPN-ISGQ 113
E +E +D + G ++L + + + ++ + ++ D KG T+F ++ +
Sbjct: 18 EIKEKFIELDANKDGFIDLHELKDALNQVGFKLAGYQVREMIDEYKGKQLTAFQGKLNLE 77
Query: 114 SNRAPPVPTKPKSIGLQHKGTGEKAQII--VGG----STSGTTHTINEEERRAFTTHINS 167
A + K K + K K + + +GG S+ GTTH++ EE+ AF+ INS
Sbjct: 78 EFEALCLDLKSKDVASTFKTVVSKKENLETLGGMSSISSEGTTHSVRLEEQLAFSDWINS 137
Query: 168 VLAGDADIGHRLPFPTDTFQLFDECRDGLVLSKLINDSVPDTIDTRVLNWPKNNKALNTF 227
L D D+ H LP ++ +L+ +DG++L K+IN S PDTID R +N K L +
Sbjct: 138 NLGHDKDLQHLLPIDSEGKRLYLSIKDGILLCKIINHSCPDTIDERAIN----KKNLTVY 193
Query: 228 TASENANIVINSAKAIGCVVVNVHSEDIIEGKEHLILGLIWQIIRRGLLSKIDIKLHPEL 287
EN + + S++AIGC +VN+ + D+ +GK HL+LGL+WQIIR GL S I + P L
Sbjct: 194 REFENLTLALVSSQAIGCNIVNIDAHDLAKGKPHLVLGLLWQIIRIGLFSHITLDSCPGL 253
Query: 288 YRLLEEDETLEQFLRLPPEQILLRWFNYHLKQAGWHRRVSNFSSDIKDGENYTVLLNQLD 347
LL ++E LE +++ PE ILLRW N+HL++AG RR +NF SDI D E Y+ LL Q+
Sbjct: 254 AGLLFDNERLEDLMKMSPEAILLRWVNHHLERAGISRRCTNFQSDIVDSEIYSHLLKQIA 313
Query: 348 SNLC--SLGPLQTTDLLERAEEVLQNAEKLECRKYLTPTALVAGNPKLNLAFVAHLFNTH 405
N +L L+ +DL RAE +LQ A KL CR +LTP +V G KLNLAFVA+LFN H
Sbjct: 314 GNDADVNLDALRESDLQSRAEIMLQQAAKLNCRSFLTPQDVVNGVYKLNLAFVANLFNNH 373
Query: 406 PGLDPLDENEPIEIEDFDAEGEREARVFTLWLNSLEVDPPVVSLFEDLKDGLVLLQAYDK 465
PGLD ++ E +E E RE + + W+NS+ V P V L+ DL DGLV+ Q +D
Sbjct: 374 PGLDKPEQIEGLE----SIEETREEKTYRNWMNSMGVAPHVNWLYSDLADGLVIFQLFDV 429
Query: 466 VIPGSVNWKVINKKSSDSELSRF-KALENTNYAVDLGKSRGFSLVGIDGSDIVDGNKLLT 524
+ PG VNW ++K+ S L +F + LEN NYAVDLGK FSLVGI G D+ DGN LT
Sbjct: 430 IKPGIVNWSRVHKRFSP--LRKFMEKLENCNYAVDLGKQLKFSLVGIAGQDLNDGNATLT 487
Query: 525 LGLVWQLMRKNIVNTMNELATTGRDMSDSQILKWAQETVSKGGKSSTIRSFSDPSLSNAH 584
L L+WQLMR ++ ++ LA TG + + +I++W +S+ GK S +R+F+DP++++
Sbjct: 488 LALIWQLMRAYTLSILSRLANTGNPIIEKEIVQWVNNRLSEAGKQSQLRNFNDPAIADGK 547
Query: 585 FLLDVLNGLAPGYVDYSLVLPGKTEEDRYANARLAISIARKLGALIWLVPEDINEVRSRL 644
++D+++ + G ++Y LV T+ED ANA+ AIS+ARK+GA ++ +PEDI EV+ ++
Sbjct: 548 IVIDLIDAIKEGSINYELVRTSGTQEDNLANAKYAISMARKIGARVYALPEDITEVKPKM 607
Query: 645 ILTFVASLMAL 655
++T A +MAL
Sbjct: 608 VMTVFACMMAL 618
>Hs7549809 [Z] KOG0046 Ca2+-binding actin-bundling protein (fimbrin/plastin)
EF-Hand protein superfamily
Length = 630
Score = 434 bits (1117), Expect = e-121
Identities = 254/662 (38%), Positives = 394/662 (59%), Gaps = 66/662 (9%)
Query: 12 EFSQEDLFETIEHFRNIDLEDKGWVEKPQILESISKSGVASYD-EARETLKTVDVDAS-- 68
+ S+++L E E F +DL G++ ++ E ++ + + RE ++ + +D
Sbjct: 8 QISKDELDELKEAFAKVDLNSNGFICDYELHELFKEANMPLPGYKVREIIQKLMLDGDRN 67
Query: 69 --GHVELEDYVELMAKLRANGSSQGTQQDEDNSKGFPQTSFPNISGQSNRAPPVPTKPKS 126
G + +++V + +++++ ++ ++ + +G
Sbjct: 68 KDGKISFDEFVYIFQEVKSSDIAKTFRKAINRKEGICALG-------------------- 107
Query: 127 IGLQHKGTGEKAQIIVGGSTSGTTHTINEEERRAFTTHINSVLAGDADIGHRLPFPTDTF 186
GT E S+ GT H+ +EEE+ AF IN L D D H +P +T
Sbjct: 108 ------GTSEL-------SSEGTQHSYSEEEKYAFVNWINKALENDPDCRHVIPMNPNTD 154
Query: 187 QLFDECRDGLVLSKLINDSVPDTIDTRVLNWPKNNKALNTFTASENANIVINSAKAIGCV 246
LF DG+VL K+IN SVPDTID R +N K L F EN N+ +NSA AIGC
Sbjct: 155 DLFKAVGDGIVLCKMINLSVPDTIDERAIN----KKKLTPFIIQENLNLALNSASAIGCH 210
Query: 247 VVNVHSEDIIEGKEHLILGLIWQIIRRGLLSKIDIKLHPELYRLLEEDETLEQFLRLPPE 306
VVN+ +ED+ GK HL+LGL+WQII+ GL + I++ + L LL + ETLE+ ++L PE
Sbjct: 211 VVNIGAEDLRAGKPHLVLGLLWQIIKIGLFADIELSRNEALAALLRDGETLEELMKLSPE 270
Query: 307 QILLRWFNYHLKQAGWHRRVSNFSSDIKDGENYTVLLNQ------------LDSNLCSLG 354
++LLRW N+HL+ +GW ++++NFS+DIKD + Y LLNQ +D N+
Sbjct: 271 ELLLRWANFHLENSGW-QKINNFSADIKDSKAYFHLLNQIAPKGQKEGEPRIDINMSG-- 327
Query: 355 PLQTTDLLERAEEVLQNAEKLECRKYLTPTALVAGNPKLNLAFVAHLFNTHPGLDPLDEN 414
TD L+RAE +LQ A+KL CR+++TP +V+GNPKLNLAFVA+LFN +P L EN
Sbjct: 328 -FNETDDLKRAESMLQQADKLGCRQFVTPADVVSGNPKLNLAFVANLFNKYPALTK-PEN 385
Query: 415 EPIEIEDFDAEGEREARVFTLWLNSLEVDPPVVSLFEDLKDGLVLLQAYDKV-IPGSVNW 473
+ I+ + E RE R F W+NSL V+P V L+ DL+D LV+LQ Y+++ +P V+W
Sbjct: 386 QDIDWTLLEGE-TREERTFRNWMNSLGVNPHVNHLYADLQDALVILQLYERIKVP--VDW 442
Query: 474 KVINKKSSDSELSRFKALENTNYAVDLGKSRG-FSLVGIDGSDIVDGNKLLTLGLVWQLM 532
+NK + K LEN NYAV+LGK FSLVGI G D+ DGN+ LTL LVWQLM
Sbjct: 443 SKVNKPPYPKLGANMKKLENCNYAVELGKHPAKFSLVGIGGQDLNDGNQTLTLALVWQLM 502
Query: 533 RKNIVNTMNELATTGRDMSDSQILKWAQETVSKGGKSSTIRSFSDPSLSNAHFLLDVLNG 592
R+ +N + +L G+ +D I+ W T+S+ GKS++I+SF D ++S++ ++D+++
Sbjct: 503 RRYTLNVLEDLG-DGQKANDDIIVNWVNRTLSEAGKSTSIQSFKDKTISSSLAVVDLIDA 561
Query: 593 LAPGYVDYSLVLPGK-TEEDRYANARLAISIARKLGALIWLVPEDINEVRSRLILTFVAS 651
+ PG ++Y LV G TE+D++ NA+ A+S+AR++GA ++ +PED+ EV+ ++++T A
Sbjct: 562 IQPGCINYDLVKSGNLTEDDKHNNAKYAVSMARRIGARVYALPEDLVEVKPKMVMTVFAC 621
Query: 652 LM 653
LM
Sbjct: 622 LM 623
>At2g04750 [Z] KOG0046 Ca2+-binding actin-bundling protein (fimbrin/plastin)
EF-Hand protein superfamily
Length = 652
Score = 432 bits (1112), Expect = e-121
Identities = 249/594 (41%), Positives = 364/594 (60%), Gaps = 27/594 (4%)
Query: 69 GHVELEDYVELMAKLRA-NGSSQGTQQDEDNSKGFPQTSFPNISGQSNRAPPVPTKP--- 124
G V ++ + AKL+ NG DE+ K S+PN RA V +
Sbjct: 38 GRVTVKHLPPVFAKLKYFNGKF-----DENEIKTILDESYPN------RAKEVEFETFLR 86
Query: 125 KSIGLQHKGTGEKAQIIVGGSTSGTTHTINEEERRAFTTHINSVLAGDADIGHRLPFPTD 184
+ +Q +G+ + A + ST+ H+INE E+ ++ +HINS L + ++ LP
Sbjct: 87 AFLSVQSRGS-KGASSFLKTSTTTFHHSINESEKASYVSHINSYLKDEPNLKSYLPINPT 145
Query: 185 TFQLFDECRDGLVLSKLINDSVPDTIDTRVLNWPKNNKALNTFTASENANIVINSAKAIG 244
T LFD +DG++L KLIN +VP TID R +N K LN + +EN ++ +NSAKAIG
Sbjct: 146 TNALFDLVKDGVLLCKLINIAVPGTIDERAIN---TKKELNPWERTENLSLCLNSAKAIG 202
Query: 245 CVVVNVHSEDIIEGKEHLILGLIWQIIRRGLLSKIDIKLHPELYRLLEEDETLEQFLRLP 304
C VVN+ ++DI EG HL+LGLI+QII+ LL+ +++K P+L L+EE++ +E+ + L
Sbjct: 203 CTVVNIGTQDIAEGTPHLVLGLIFQIIKIQLLADLNLKKTPQLVELVEENQDVEELMGLA 262
Query: 305 PEQILLRWFNYHLKQAGWHRRVSNFSSDIKDGENYTVLLNQLDSNLCSLGPLQTTDLLER 364
PE++LL+W N+HLK+AG+ ++V+NFSSD+KDGE Y LLN L + L+ D ER
Sbjct: 263 PEKLLLKWMNFHLKKAGYEKQVTNFSSDVKDGEAYAYLLNALAPEHSTNVTLEIKDPSER 322
Query: 365 AEEVLQNAEKLECRKYLTPTALVAGNPKLNLAFVAHLFNTHPGLDPLDENEPIEIEDF-- 422
A +VL+ AEKL+C+++L+P +V G+ LNLAFVA LF+ GL PI + +
Sbjct: 323 ATKVLEQAEKLDCKRFLSPKDIVEGSANLNLAFVAQLFHHRNGLSDESPKVPISVAEMVT 382
Query: 423 -DAEGEREARVFTLWLNSLEVDPPVVSLFEDLKDGLVLLQAYDKVIPGSVNWKVINKKSS 481
D E RE R F W+NSL V ++FED+++G VLL+ DKV PGSVNWK NK
Sbjct: 383 EDEETSREERCFRHWMNSLGAVTYVDNVFEDVRNGWVLLEVLDKVSPGSVNWKHANKPPI 442
Query: 482 DSELSRFKALENTNYAVDLGKSRGFSLVGIDGSDIVDGNKLLTLGLVWQLMRKNIVNTMN 541
FK +EN N + +GK FSLV + G DI+ GNK L L +WQLMR ++ +N
Sbjct: 443 KMP---FKKVENCNQVIKIGKELNFSLVNVAGHDIMQGNKKLLLAFLWQLMRYTMLQILN 499
Query: 542 ELAT--TGRDMSDSQILKWAQETVSKGGKSSTIRSFSDPSLSNAHFLLDVLNGLAPGYVD 599
L + G+D++++ IL WA V K G++S SF D +L+N F L++L+ + P V+
Sbjct: 500 NLRSHCQGKDITEADILNWANRKVKKSGRTSQAVSFKDKNLANGIFFLELLSAVEPRVVN 559
Query: 600 YSLVLPGKTEEDRYANARLAISIARKLGALIWLVPEDINEVRSRLILTFVASLM 653
+SLV G+T+E++ NA IS+ARKLG I+L+PEDI EV R++L AS+M
Sbjct: 560 WSLVSKGETQEEKNLNATYIISVARKLGCSIFLLPEDILEVNQRMMLILAASIM 613
>At5g55400 [Z] KOG0046 Ca2+-binding actin-bundling protein (fimbrin/plastin)
EF-Hand protein superfamily
Length = 714
Score = 432 bits (1110), Expect = e-120
Identities = 237/590 (40%), Positives = 359/590 (60%), Gaps = 12/590 (2%)
Query: 68 SGHVELEDYVELMAKLRANGSSQGTQQDED--NSKGFPQTSFPNISGQSNRAPPVPTKPK 125
SG V LED ++ K+++ SS ++ ++ G S ++ +S + + K
Sbjct: 37 SGKVTLEDLPSVLVKVKSLSSSFKEKEIKEILGGLGSDYESDDDLDFESFLKVYLNLRDK 96
Query: 126 SIGLQHKGTGEKAQIIVGGSTSGTTHTINEEERRAFTTHINSVLAGDADIGHRLPFPTDT 185
+ G + + G+T T HTIN+ E+ +F HIN L D + LP D+
Sbjct: 97 AADKAGGGLKHSSSFLKAGTT--TLHTINQSEKGSFVLHINRYLGDDPFLKQFLPLDPDS 154
Query: 186 FQLFDECRDGLVLSKLINDSVPDTIDTRVLNWPKNNKALNTFTASENANIVINSAKAIGC 245
L++ +DG++L KLIN +VP TID R +N + LN + +EN + +NSAKA+GC
Sbjct: 155 NDLYELVKDGVLLCKLINIAVPGTIDERAIN---TKRVLNPWERNENHTLCLNSAKAVGC 211
Query: 246 VVVNVHSEDIIEGKEHLILGLIWQIIRRGLLSKIDIKLHPELYRLLEEDETLEQFLRLPP 305
VVN+ ++D+ EG+ HL+LGLI Q+I+ LL+ + +K P+L L+E++E +E+FLRLPP
Sbjct: 212 SVVNIGTQDLAEGRPHLVLGLISQLIKIQLLADLSLKKMPQLVELVEDNEDIEEFLRLPP 271
Query: 306 EQILLRWFNYHLKQAGWHRRVSNFSSDIKDGENYTVLLNQLDSNLCSLGPLQTTDLLERA 365
E++LL+W N+HLK+ G+ + V NFSSD+KD + Y LLN L C L D LERA
Sbjct: 272 EKVLLKWMNFHLKKGGYKKTVGNFSSDLKDAQAYAYLLNVLAPEHCDPATLNAEDDLERA 331
Query: 366 EEVLQNAEKLECRKYLTPTALVAGNPKLNLAFVAHLFNTHPGLDPLDENEPIEIEDFDAE 425
VL++AE++ C++YLT +V G+ LNLAFVA +F+ GL E+ D +
Sbjct: 332 NMVLEHAERMNCKRYLTAEEIVEGSSYLNLAFVAQIFHERNGLSTDGRFSFAEMMTEDLQ 391
Query: 426 GEREARVFTLWLNSLEVDPPVVSLFEDLKDGLVLLQAYDKVIPGSVNWKVINKKSSDSEL 485
R+ R + LW+NSL ++ V ++FED+++G +LL+ DKV PGSVNWK +K
Sbjct: 392 TCRDERCYRLWINSLGIESYVNNVFEDVRNGWILLEVVDKVYPGSVNWKQASKPPIKMP- 450
Query: 486 SRFKALENTNYAVDLGKSRGFSLVGIDGSDIVDGNKLLTLGLVWQLMRKNIVNTMNEL-- 543
F+ +EN N V +GK FSLV + G+DIV GNK L LG +WQLMR +++ + L
Sbjct: 451 --FRKVENCNQVVKIGKEMRFSLVNVAGNDIVQGNKKLILGFLWQLMRTHMLQLLKSLRS 508
Query: 544 ATTGRDMSDSQILKWAQETVSKGGKSSTIRSFSDPSLSNAHFLLDVLNGLAPGYVDYSLV 603
T G+DM+DS+I+ WA V G+ S I SF D SLS+ F LD+L + P V+++LV
Sbjct: 509 RTRGKDMTDSEIISWANRKVRIMGRKSQIESFKDKSLSSGLFFLDLLWAVEPRVVNWNLV 568
Query: 604 LPGKTEEDRYANARLAISIARKLGALIWLVPEDINEVRSRLILTFVASLM 653
G++++++ NA +S+ARKLG ++L+PEDI EV ++IL AS+M
Sbjct: 569 TKGESDDEKRLNATYIVSVARKLGCSVFLLPEDIVEVNQKMILILTASIM 618
>At5g35700 [Z] KOG0046 Ca2+-binding actin-bundling protein (fimbrin/plastin)
EF-Hand protein superfamily
Length = 687
Score = 432 bits (1110), Expect = e-120
Identities = 245/591 (41%), Positives = 359/591 (60%), Gaps = 17/591 (2%)
Query: 69 GHVELEDYVELMAKLRA-NGSSQGTQQDEDNSKGFPQTSFPNISGQSNRAPPVPT--KPK 125
G + D + KL+A NG+ DED K S+PN + + + +
Sbjct: 38 GRFTVGDLPPVFEKLKAFNGTI-----DEDEIKSVLDKSYPNADDEVDFEFFLRAFLSVQ 92
Query: 126 SIGLQHKGTGEKAQIIVGGSTSGTTHTINEEERRAFTTHINSVLAGDADIGHRLPFPTDT 185
+ G++ G + A + ST+ H INE E+ ++ +H+N+ L D + LP T
Sbjct: 93 ARGVEKSGGSKGASSFLKTSTTTVHHAINESEKASYVSHVNNYLRDDPFLKSYLPIDPAT 152
Query: 186 FQLFDECRDGLVLSKLINDSVPDTIDTRVLNWPKNNKALNTFTASENANIVINSAKAIGC 245
FD +DG++L KLIN +VP TID R +N K LN + +EN + +NSAKAIGC
Sbjct: 153 NAFFDLVKDGVLLCKLINVAVPGTIDERAIN---TKKTLNPWERNENLTLGLNSAKAIGC 209
Query: 246 VVVNVHSEDIIEGKEHLILGLIWQIIRRGLLSKIDIKLHPELYRLLEEDETLEQFLRLPP 305
VVN+ ++DI EG+ +L+LGLI QII+ +L+ ++ K P L++L+++ + E+ + L P
Sbjct: 210 TVVNIGTQDIAEGRPYLVLGLISQIIKIQMLADLNFKKTPSLFQLVDDTQDAEELMGLAP 269
Query: 306 EQILLRWFNYHLKQAGWHRRVSNFSSDIKDGENYTVLLNQLDSNLCSLGPLQTTDLLERA 365
E++LL+W N+HLK+AG+ ++V+NFSSD+KDGE Y LLN L + L+T D ERA
Sbjct: 270 EKVLLKWMNFHLKKAGYEKQVTNFSSDLKDGEAYAYLLNALAPEHSTHVALETKDPTERA 329
Query: 366 EEVLQNAEKLECRKYLTPTALVAGNPKLNLAFVAHLFNTHPGLDPLDENEPI-EIEDFDA 424
++VL+ AEKL+C++YL+P +V G+ LNLAFVA +F GL D E+ D
Sbjct: 330 KKVLEQAEKLDCKRYLSPKDIVDGSANLNLAFVAQIFQHRNGLTVDDSKTSFAEMMTDDV 389
Query: 425 EGEREARVFTLWLNSLEVDPPVVSLFEDLKDGLVLLQAYDKVIPGSVNWKVINKKSSDSE 484
E RE R F LW+NSL V ++FEDL++G VLL+ DKV PGSVNWK NK
Sbjct: 390 ETSREERCFRLWINSLGTATYVNNVFEDLRNGWVLLEVLDKVSPGSVNWKHANKPPIKMP 449
Query: 485 LSRFKALENTNYAVDLGKSRGFSLVGIDGSDIVDGNKLLTLGLVWQLMRKNIVNTMNELA 544
FK +EN N + +GK FSLV + G+DIV GNK L L +WQLMR ++ + L
Sbjct: 450 ---FKKVENCNEVIKIGKELRFSLVNVAGNDIVQGNKKLLLAFLWQLMRYTMLQLLRNLR 506
Query: 545 --TTGRDMSDSQILKWAQETVSKGGKSSTIRSFSDPSLSNAHFLLDVLNGLAPGYVDYSL 602
+ G++++D+ IL WA V +GG++S SF D +LS+ F L++L+ + P V++SL
Sbjct: 507 SHSQGKEITDADILNWANRKVKRGGRTSQADSFRDKNLSSGMFFLELLSAVEPRVVNWSL 566
Query: 603 VLPGKTEEDRYANARLAISIARKLGALIWLVPEDINEVRSRLILTFVASLM 653
V G+TEED+ NA IS+ARKLG I+L+PEDI EV +++L AS+M
Sbjct: 567 VTNGETEEDKKLNATYIISVARKLGCSIFLLPEDIIEVNQKMMLILAASIM 617
>Hs4505897 [Z] KOG0046 Ca2+-binding actin-bundling protein (fimbrin/plastin)
EF-Hand protein superfamily
Length = 629
Score = 431 bits (1108), Expect = e-120
Identities = 256/655 (39%), Positives = 376/655 (57%), Gaps = 57/655 (8%)
Query: 14 SQEDLFETIEHFRNIDLEDKGWVEKPQILE-----SISKSGVASYDEARETLKTVDVDAS 68
S+E+L E E F ID+++ G+V ++ + S+ G + + L D +
Sbjct: 9 SREELEELQEAFNKIDIDNSGYVSDYELQDLFKEASLPLPGYKVREIVEKILSVADSNKD 68
Query: 69 GHVELEDYVELMAKLRANGSSQGTQQDEDNSKGFPQTSFPNISGQSNRAPPVPTKPKSIG 128
G + E++V LM +L++ S+ ++ + +G I G S
Sbjct: 69 GKISFEEFVSLMQELKSKDISKTFRKIINKREGITA-----IGGTSTI------------ 111
Query: 129 LQHKGTGEKAQIIVGGSTSGTTHTINEEERRAFTTHINSVLAGDADIGHRLPFPTDTFQL 188
S+ GT H+ +EEE+ AF IN L D D H +P + L
Sbjct: 112 ----------------SSEGTQHSYSEEEKVAFVNWINKALENDPDCKHLIPMNPNDDSL 155
Query: 189 FDECRDGLVLSKLINDSVPDTIDTRVLNWPKNNKALNTFTASENANIVINSAKAIGCVVV 248
F DG++L K+IN S PDTID R + N K L FT SEN N+ +NSA AIGC VV
Sbjct: 156 FKSLADGILLCKMINLSEPDTIDERAI----NKKKLTPFTISENLNLALNSASAIGCTVV 211
Query: 249 NVHSEDIIEGKEHLILGLIWQIIRRGLLSKIDIKLHPELYRLLEEDETLEQFLRLPPEQI 308
N+ + D+ EGK HL+LGL+WQII+ GL + I+I + L LL E E LE+ ++L PE++
Sbjct: 212 NIGASDLKEGKPHLVLGLLWQIIKVGLFADIEISRNEALIALLNEGEELEELMKLSPEEL 271
Query: 309 LLRWFNYHLKQAGWHRRVSNFSSDIKDGENYTVLLNQLDSNLCSLGPLQTTDL------- 361
LLRW NYHL AGWH +SNFS DIKD Y LLNQ+ GP DL
Sbjct: 272 LLRWVNYHLTNAGWH-TISNFSQDIKDSRAYFHLLNQIAPKGGEDGPAIAIDLSGINETN 330
Query: 362 -LERAEEVLQNAEKLECRKYLTPTALVAGNPKLNLAFVAHLFNTHPGLDPLDENEPIEIE 420
L+RA +LQ A+KL C++++TP +V+GNPKLNLAFVA+LFNT+P L + N+ I++
Sbjct: 331 DLKRAGLMLQEADKLGCKQFVTPADVVSGNPKLNLAFVANLFNTYPCLHKPNNND-IDMN 389
Query: 421 DFDAEGEREARVFTLWLNSLEVDPPVVSLFEDLKDGLVLLQAYDKVIPGSVNWKVINKKS 480
+ E +E R F W+NSL V+P + L+ DL D LV+ Q Y+ +I VNW +NK
Sbjct: 390 LLEGE-SKEERTFRNWMNSLGVNPYINHLYSDLADALVIFQLYE-MIRVPVNWSHVNKPP 447
Query: 481 SDSELSRFKALENTNYAVDLGKSRG-FSLVGIDGSDIVDGNKLLTLGLVWQLMRKNIVNT 539
+ K +EN NYAV+LGK++ FSLVGI G D+ + N LTL LVWQLMR+ +N
Sbjct: 448 YPALGGNMKKIENCNYAVELGKNKAKFSLVGIAGQDLNERNSTLTLALVWQLMRRYTLNV 507
Query: 540 MNELATTGRDMSDSQILKWAQETVSKGGKSSTIRSFSDPSLSNAHFLLDVLNGLAPGYVD 599
+++L G ++D I+KW +T+ K ++I SF D S+S + +LD+++ +AP V
Sbjct: 508 LSDLG-EGEKVNDEIIIKWVNQTLKSANKKTSISSFKDKSISTSLPVLDLIDAIAPNAVR 566
Query: 600 YSLV-LPGKTEEDRYANARLAISIARKLGALIWLVPEDINEVRSRLILTFVASLM 653
++ ++ED+ NA+ AIS+ARK+GA I+ +P+D+ EV+ ++++T A LM
Sbjct: 567 QEMIRRENLSDEDKLNNAKYAISVARKIGARIYALPDDLVEVKPKMVMTVFACLM 621
>Hs4504965 [Z] KOG0046 Ca2+-binding actin-bundling protein (fimbrin/plastin)
EF-Hand protein superfamily
Length = 627
Score = 424 bits (1090), Expect = e-118
Identities = 247/657 (37%), Positives = 384/657 (57%), Gaps = 60/657 (9%)
Query: 14 SQEDLFETIEHFRNIDLEDKGWVEKPQILESISKS-----GVASYDEARETLKTVDVDAS 68
S E++ E E F +D + G++ ++ + + G + + T D+D
Sbjct: 7 SDEEMMELREAFAKVDTDGNGYISFNELNDLFKAACLPLPGYRVREITENLMATGDLDQD 66
Query: 69 GHVELEDYVELMAKLRANGSSQGTQQDEDNSKGFPQTSFPNISGQSNRAPPVPTKPKSIG 128
G + ++++++ L++ ++ ++ + +G +IG
Sbjct: 67 GRISFDEFIKIFHGLKSTDVAKTFRKAINKKEGIC----------------------AIG 104
Query: 129 LQHKGTGEKAQIIVGGSTSGTTHTINEEERRAFTTHINSVLAGDADIGHRLPFPTDTFQL 188
GT E++ + GT H+ +EEE+ AF IN L D D H +P +T L
Sbjct: 105 ----GTSEQSSV-------GTQHSYSEEEKYAFVNWINKALENDPDCRHVIPMNPNTNDL 153
Query: 189 FDECRDGLVLSKLINDSVPDTIDTRVLNWPKNNKALNTFTASENANIVINSAKAIGCVVV 248
F+ DG+VL K+IN SVPDTID R +N K L FT EN N+ +NSA AIGC VV
Sbjct: 154 FNAVGDGIVLCKMINLSVPDTIDERTIN----KKKLTPFTIQENLNLALNSASAIGCHVV 209
Query: 249 NVHSEDIIEGKEHLILGLIWQIIRRGLLSKIDIKLHPELYRLLEEDETLEQFLRLPPEQI 308
N+ +ED+ EGK +L+LGL+WQ+I+ GL + I++ + L LL E E+LE ++L PE++
Sbjct: 210 NIGAEDLKEGKPYLVLGLLWQVIKIGLFADIELSRNEALIALLREGESLEDLMKLSPEEL 269
Query: 309 LLRWFNYHLKQAGWHRRVSNFSSDIKDGENYTVLLNQ---------LDSNLCSLGPLQTT 359
LLRW NYHL+ AG + ++ NFS+DIKD + Y LL Q + + + + L+
Sbjct: 270 LLRWANYHLENAGCN-KIGNFSTDIKDSKAYYHLLEQVAPKGDEEGVPAVVIDMSGLREK 328
Query: 360 DLLERAEEVLQNAEKLECRKYLTPTALVAGNPKLNLAFVAHLFNTHPGLDPLDENEPIEI 419
D ++RAE +LQ AE+L CR+++T T +V GNPKLNLAF+A+LFN +P L EN+ I+
Sbjct: 329 DDIQRAECMLQQAERLGCRQFVTATDVVRGNPKLNLAFIANLFNRYPALHK-PENQDIDW 387
Query: 420 EDFDAEGEREARVFTLWLNSLEVDPPVVSLFEDLKDGLVLLQAYDKV-IPGSVNWKVINK 478
+ E RE R F W+NSL V+P V L+ DL D LV+ Q Y+K+ +P V+W +NK
Sbjct: 388 GALEGE-TREERTFRNWMNSLGVNPRVNHLYSDLSDALVIFQLYEKIKVP--VDWNRVNK 444
Query: 479 KSSDSELSRFKALENTNYAVDLGKSRG-FSLVGIDGSDIVDGNKLLTLGLVWQLMRKNIV 537
K LEN NYAV+LGK++ FSLVGI G D+ +GN+ LTL L+WQLMR+ +
Sbjct: 445 PPYPKLGGNMKKLENCNYAVELGKNQAKFSLVGIGGQDLNEGNRTLTLALIWQLMRRYTL 504
Query: 538 NTMNELATTGRDMSDSQILKWAQETVSKGGKSSTIRSFSDPSLSNAHFLLDVLNGLAPGY 597
N + E+ G+ ++D I+ W ET+ + KSS+I SF DP +S + +LD+++ + PG
Sbjct: 505 NILEEIG-GGQKVNDDIIVNWVNETLREAEKSSSISSFKDPKISTSLPVLDLIDAIQPGS 563
Query: 598 VDYSLV-LPGKTEEDRYANARLAISIARKLGALIWLVPEDINEVRSRLILTFVASLM 653
++Y L+ ++++ NA+ AIS+ARK+GA ++ +PED+ EV ++++T A LM
Sbjct: 564 INYDLLKTENLNDDEKLNNAKYAISMARKIGARVYALPEDLVEVNPKMVMTVFACLM 620
>At4g26700 [Z] KOG0046 Ca2+-binding actin-bundling protein (fimbrin/plastin)
EF-Hand protein superfamily
Length = 687
Score = 414 bits (1064), Expect = e-115
Identities = 236/595 (39%), Positives = 355/595 (59%), Gaps = 23/595 (3%)
Query: 68 SGHVELEDYVELMAKLRANGSSQGTQQDEDNSKGF----PQTSFPNISGQSNRAPPVPTK 123
+G V +ED L AKL+A ++ ED KG + ++S + +
Sbjct: 37 NGKVTIEDLPPLFAKLKALSATF----KEDEIKGMLGELGSDTSTDVSFEEFLKIYLNLL 92
Query: 124 PKSI---GLQHKGTGEKAQIIVGGSTSGTTHTINEEERRAFTTHINSVLAGDADIGHRLP 180
K+ G HK + + T+ HTI + E+ F HIN L D + LP
Sbjct: 93 SKAAEKSGGHHKNSSS----FLKACTTTLLHTIYQSEKGPFVQHINRYLGDDPFLKQFLP 148
Query: 181 FPTDTFQLFDECRDGLVLSKLINDSVPDTIDTRVLNWPKNNKALNTFTASENANIVINSA 240
+ QL++ +DG++L KLIN +VP TID R +N + LN + +EN + +NSA
Sbjct: 149 LDPHSNQLYELVKDGVLLCKLINVAVPGTIDERAIN---TKRVLNPWERNENHTLCLNSA 205
Query: 241 KAIGCVVVNVHSEDIIEGKEHLILGLIWQIIRRGLLSKIDIKLHPELYRLLEEDETLEQF 300
KA+GC VVN+ ++D+ EG+ HL+LGLI Q+I+ +L+ +++K P+L LLE+ + +E+
Sbjct: 206 KAVGCSVVNIGTQDLAEGRPHLVLGLISQLIKIQVLADLNLKKTPQLVELLEDSDDVEEL 265
Query: 301 LRLPPEQILLRWFNYHLKQAGWHRRVSNFSSDIKDGENYTVLLNQLDSNLCSLGPLQTTD 360
LRLPPE++LL+W N+HLK+ G+ + VSNFS+D+KD + Y LLN L C L D
Sbjct: 266 LRLPPEKVLLKWMNFHLKKGGYKKTVSNFSADLKDAQAYAFLLNVLAPEHCDPATLDAKD 325
Query: 361 LLERAEEVLQNAEKLECRKYLTPTALVAGNPKLNLAFVAHLFNTHPGLDPLDENEPIEIE 420
LERAE VL +AE++ C++YLT +V G+ LNLAFVA +F+ GL+ + E+
Sbjct: 326 PLERAELVLSHAERMNCKRYLTAEEIVEGSSTLNLAFVAQIFHERNGLNKDGKYAFAEMM 385
Query: 421 DFDAEGEREARVFTLWLNSLEVDPPVVSLFEDLKDGLVLLQAYDKVIPGSVNWKVINKKS 480
D E R+ R + LW+NSL +D V ++FED+++G +LL+ DKV P SVNWK +K
Sbjct: 386 TEDVETCRDERCYRLWINSLGIDSYVNNVFEDVRNGWILLEVLDKVSPSSVNWKHASKPP 445
Query: 481 SDSELSRFKALENTNYAVDLGKSRGFSLVGIDGSDIVDGNKLLTLGLVWQLMRKNIVNTM 540
F+ +EN N + +GK FSLV + G+DIV GNK L LGL+WQLMR +++ +
Sbjct: 446 IKMP---FRKVENCNQVIKIGKQLKFSLVNVAGNDIVQGNKKLILGLLWQLMRFHMLQLL 502
Query: 541 NEL--ATTGRDMSDSQILKWAQETVSKGGKSSTIRSFSDPSLSNAHFLLDVLNGLAPGYV 598
L T G++M+D+ IL WA V G+ I SF D SLS+ F L++L + P V
Sbjct: 503 KSLRSRTLGKEMTDADILSWANRKVRTMGRKLQIESFKDKSLSSGLFFLNLLWAVEPRVV 562
Query: 599 DYSLVLPGKTEEDRYANARLAISIARKLGALIWLVPEDINEVRSRLILTFVASLM 653
+++LV G+T++++ NA +S+ARKLG ++L+PEDI EV ++IL AS+M
Sbjct: 563 NWNLVTKGETDDEKRLNATYIVSVARKLGCSVFLLPEDIVEVNQKMILILTASIM 617
>At5g48460 [Z] KOG0046 Ca2+-binding actin-bundling protein (fimbrin/plastin)
EF-Hand protein superfamily
Length = 654
Score = 410 bits (1053), Expect = e-114
Identities = 227/525 (43%), Positives = 329/525 (62%), Gaps = 10/525 (1%)
Query: 133 GTGEK-AQIIVGGSTSGTTHTINEEERRAFTTHINSVLAGDADIGHRLPFPTDTFQLFDE 191
G+G K + + +T+ HTI++ E+ ++ HIN+ L+GD + LP + LF+
Sbjct: 101 GSGVKNSSAFLKAATTTLLHTISDSEKSSYVAHINNYLSGDEFLNKCLPINPSSNDLFEV 160
Query: 192 CRDGLVLSKLINDSVPDTIDTRVLNWPKNNKALNTFTASENANIVINSAKAIGCVVVNVH 251
+DG++L KLIN +VP TID R +N LN + +EN + +NSAKAIGC VVN+
Sbjct: 161 AKDGVLLCKLINVAVPGTIDERAIN---TKSMLNPWERNENHTLCLNSAKAIGCTVVNIG 217
Query: 252 SEDIIEGKEHLILGLIWQIIRRGLLSKIDIKLHPELYRLLEEDETLEQFLRLPPEQILLR 311
++DIIEG+ HL+LG+I QII+ LL+ +++K P+L L+ + + +E+ + LPPE+ILLR
Sbjct: 218 TQDIIEGRRHLVLGVISQIIKIQLLADLNLKKTPQLVELVGDSKDVEELMSLPPEKILLR 277
Query: 312 WFNYHLKQAGWHRRVSNFSSDIKDGENYTVLLNQLDSNLCSLGPLQTTDLLERAEEVLQN 371
W N+ L++ + + V+NFSSD+KD E YT LLN L + L ERA+ VL++
Sbjct: 278 WMNFQLRKTEYKKTVTNFSSDVKDAEAYTNLLNVLAPEHKNPSHLAVKSSFERAKLVLEH 337
Query: 372 AEKLECRKYLTPTALVAGNPKLNLAFVAHLFNTHPGLDPLDEN-EPIEIEDFDAEGEREA 430
A+K+ CR+YLT +V G+P LNLAFVAH+F GL + +E D + RE
Sbjct: 338 ADKMGCRRYLTAKDIVEGSPNLNLAFVAHIFQHRNGLSTQTKQISFLENLADDIQISREE 397
Query: 431 RVFTLWLNSLEVDPPVVSLFEDLKDGLVLLQAYDKVIPGSVNWKVINKKSSDSELSRFKA 490
+ F W+NS + + ++FEDL+DG +LLQ DKV PG VNWKV +K FK
Sbjct: 398 KAFRFWINSFDGSVYINNVFEDLRDGWILLQTLDKVSPGIVNWKVSSKPPIKLP---FKK 454
Query: 491 LENTNYAVDLGKSRGFSLVGIDGSDIVDGNKLLTLGLVWQLMRKNIVNTMNELA--TTGR 548
+EN N V LGK FSLV I G+DIV GNK L L +WQLMR NI+ + L + G+
Sbjct: 455 VENCNQVVKLGKQLKFSLVNIAGNDIVQGNKKLILAYLWQLMRYNILQLLKNLRLHSNGK 514
Query: 549 DMSDSQILKWAQETVSKGGKSSTIRSFSDPSLSNAHFLLDVLNGLAPGYVDYSLVLPGKT 608
+++D+ IL+WA V G + + SF D SLS+ F L++L+ + P V++SLV G T
Sbjct: 515 EITDADILEWANAKVRNNGCKTRMYSFRDKSLSDGVFFLELLSSVQPRSVNWSLVTNGVT 574
Query: 609 EEDRYANARLAISIARKLGALIWLVPEDINEVRSRLILTFVASLM 653
+E++ NA ISIARKLG I+L+PEDI EV +++LT AS+M
Sbjct: 575 DEEKKMNATYVISIARKLGCSIFLLPEDIIEVNQKMMLTLTASIM 619
>CE27452 [Z] KOG0046 Ca2+-binding actin-bundling protein (fimbrin/plastin)
EF-Hand protein superfamily
Length = 208
Score = 159 bits (401), Expect = 2e-38
Identities = 77/165 (46%), Positives = 114/165 (68%), Gaps = 1/165 (0%)
Query: 491 LENTNYAVDLGKSRGFSLVGIDGSDIVDGNKLLTLGLVWQLMRKNIVNTMNELATTGRDM 550
++N NYAV+LGK FSLVGI G DI DGN+ LTL LVWQLMR ++ + + +G +
Sbjct: 21 IQNCNYAVELGKQLRFSLVGIQGKDIYDGNQTLTLALVWQLMRAYTLSVLAQCTQSGDSL 80
Query: 551 -SDSQILKWAQETVSKGGKSSTIRSFSDPSLSNAHFLLDVLNGLAPGYVDYSLVLPGKTE 609
+D I+ W E + GKS++IRSF DP++S+ +LD+++ + P +D+SLV GK+
Sbjct: 81 PADKDIVAWVNEKLKNSGKSTSIRSFQDPAISDGKVVLDLIDAIKPNVIDHSLVKSGKSN 140
Query: 610 EDRYANARLAISIARKLGALIWLVPEDINEVRSRLILTFVASLMA 654
ED+ +NA+ AI+ RK+GA I+ +PEDI EV+ +++LT A LMA
Sbjct: 141 EDKMSNAKYAITCGRKIGAKIYALPEDIVEVKPKMVLTVFACLMA 185
Score = 52.0 bits (123), Expect = 3e-06
Identities = 42/177 (23%), Positives = 74/177 (41%), Gaps = 21/177 (11%)
Query: 231 ENANIVINSAKAIGCVVVNVHSEDIIEGKEHLILGLIWQIIRRGLLSKIDIKLHPELYRL 290
+N N + K + +V + +DI +G + L L L+WQ++R LS +
Sbjct: 22 QNCNYAVELGKQLRFSLVGIQGKDIYDGNQTLTLALVWQLMRAYTLSVL----------- 70
Query: 291 LEEDETLEQFLRLPPEQILLRWFNYHLKQAGWHRRVSNFSSD-IKDGENYTVLL-----N 344
+ + LP ++ ++ W N LK +G + +F I DG+ L+ N
Sbjct: 71 ---AQCTQSGDSLPADKDIVAWVNEKLKNSGKSTSIRSFQDPAISDGKVVLDLIDAIKPN 127
Query: 345 QLDSNLCSLGPLQTTDLLERAEEVLQNAEKLECRKYLTPTALVAGNPKLNLAFVAHL 401
+D +L G D + A+ + K+ + Y P +V PK+ L A L
Sbjct: 128 VIDHSLVKSGK-SNEDKMSNAKYAITCGRKIGAKIYALPEDIVEVKPKMVLTVFACL 183
>CE26481 [Z] KOG0046 Ca2+-binding actin-bundling protein (fimbrin/plastin)
EF-Hand protein superfamily
Length = 198
Score = 130 bits (328), Expect = 5e-30
Identities = 70/130 (53%), Positives = 91/130 (69%), Gaps = 3/130 (2%)
Query: 284 HPELYRLLEEDETLEQFLRLPPEQILLRWFNYHLKQAGWHRRVSNFSSDIKDGENYTVLL 343
+P++ RLL + ETLE RL PE+IL+RW NYHL++AG RR+ NF+SDI D E YT LL
Sbjct: 54 NPQISRLLRDGETLEDLRRLSPEEILMRWVNYHLERAGTQRRLHNFTSDIVDSEIYTHLL 113
Query: 344 NQLDSN--LCSLGPLQTTDLLERAEEVLQNAEKLECRKYLTPTALVAGNPKLNLAFVAHL 401
+Q+ N +L PL + RA +L AEKL+CR+++T T + AGN KLNLAFVA+L
Sbjct: 114 HQIAPNGSGVTLSPLGVHGNVPRAGAMLDEAEKLDCREFVTATDVAAGNYKLNLAFVANL 173
Query: 402 FNTHPGL-DP 410
FN HP L DP
Sbjct: 174 FNKHPNLPDP 183
>CE26598_2 [Z] KOG0046 Ca2+-binding actin-bundling protein (fimbrin/plastin)
EF-Hand protein superfamily
Length = 167
Score = 129 bits (325), Expect = 1e-29
Identities = 62/143 (43%), Positives = 97/143 (67%), Gaps = 1/143 (0%)
Query: 513 GSDIVDGNKLLTLGLVWQLMRKNIVNTMNELATTGRDM-SDSQILKWAQETVSKGGKSST 571
G I DGN++LTL LVWQLMR ++ + + +G + +D I+ W E + GKS++
Sbjct: 2 GRHIYDGNQILTLALVWQLMRAYTLSVLAQYTQSGDSLPTDKDIVAWVNEKLKNSGKSTS 61
Query: 572 IRSFSDPSLSNAHFLLDVLNGLAPGYVDYSLVLPGKTEEDRYANARLAISIARKLGALIW 631
IRSF DP++S+ +LD+++ + P +D+SLV GK+ ED+ +NA+ AI+ RK+GA I+
Sbjct: 62 IRSFQDPAISDGKVVLDLIDSIKPNVIDHSLVKSGKSNEDKMSNAKYAITCGRKIGAKIY 121
Query: 632 LVPEDINEVRSRLILTFVASLMA 654
+PEDI EV+ +++LT A LMA
Sbjct: 122 ALPEDIVEVKPKMVLTVFACLMA 144
>SPAC15A10.08 [Z] KOG0035 Ca2+-binding actin-bundling protein (actinin) alpha
chain (EF-Hand protein superfamily)
Length = 621
Score = 80.5 bits (197), Expect = 8e-15
Identities = 70/227 (30%), Positives = 110/227 (47%), Gaps = 22/227 (9%)
Query: 431 RVFTLWLN---SLEVDPPVVSLFEDLKDGLVLLQAYDKVIPGSVNWKVINKKSSDSELSR 487
R FT W N S P V L +DL DG++L+Q + I G N N+ R
Sbjct: 12 RTFTKWFNTKLSSRDLPSVFDLRKDLSDGILLIQLLE--IIGDENLGRYNRNPR----MR 65
Query: 488 FKALENTNYAVDLGKSRGFSLVGIDGSDIVDGNKLLTLGLVWQLMRKNIVNTMNELATTG 547
LEN N A++ KS+G L I +DIVDGN L LGL+W L+ + + +NE T
Sbjct: 66 VHRLENVNKALEYIKSKGMPLTNIGPADIVDGNLKLILGLIWTLILRFTIADINEEGLTA 125
Query: 548 RDMSDSQILKWAQETVSKGGKSSTIRSFSDPSLSNAHFLLDVLNGLAPGYVDYSLVLPGK 607
++ +L W Q + ++ F+ S +N +++ P +DY+ +
Sbjct: 126 KE----GLLLWCQRKTANYHPEVDVQDFT-RSWTNGLAFCALIHQHRPDLLDYNKL---- 176
Query: 608 TEEDRYANARLAISIARK-LGALIWLVPEDINEV---RSRLILTFVA 650
+++ AN +LA IA+K +G + ED+ +V R I+T+VA
Sbjct: 177 DKKNHRANMQLAFDIAQKSIGIPRLIEVEDVCDVDRPDERSIMTYVA 223
>Hs15011908 [Z] KOG0516 Dystonin GAS (Growth-arrest-specific protein) and
related proteins
Length = 2350
Score = 75.9 bits (185), Expect = 2e-13
Identities = 68/249 (27%), Positives = 111/249 (44%), Gaps = 24/249 (9%)
Query: 411 LDENEPIEIEDFDAEGEREARVFTLWLNS--LEVDPPVVSLFEDLKDGLVLLQAYDKVIP 468
LD E + D + + FT W+N ++V + L+EDL+DG L+ + V+
Sbjct: 62 LDPAERAVVRVADERDRVQKKTFTKWVNKHLMKVRKHINDLYEDLRDGHNLISLLE-VLS 120
Query: 469 GSVNWKVINKKSSDSELSRFKALENTNYAVDLGKSRGFSLVGIDGSDIVDGNKLLTLGLV 528
G K + RF L+N A+D K R LV I DI DGN LTLGL+
Sbjct: 121 GI-------KLPREKGRMRFHRLQNVQIALDFLKQRQVKLVNIRNDDITDGNPKLTLGLI 173
Query: 529 WQLMRKNIVNTMNELATTGRDMSDSQILKWAQETVS--KGGKSSTIRS-FSDPSLSNAHF 585
W ++ ++ + +G + ++L W Q+ + G K + S +SD + NA
Sbjct: 174 WTIILHFQISDIYISGESGDMSAKEKLLLWTQKVTAGYTGIKCTNFSSCWSDGKMFNA-- 231
Query: 586 LLDVLNGLAPGYVDYSLVLPGKTEEDRYANARLAISIARKLGALIWLVPEDIN--EVRSR 643
+++ P VD V E N A +A +LG L ED++ +
Sbjct: 232 ---LIHRYRPDLVDMERVQIQSNRE----NLEQAFEVAERLGVTRLLDAEDVDVPSPDEK 284
Query: 644 LILTFVASL 652
++T+V+S+
Sbjct: 285 SVITYVSSI 293
Score = 57.4 bits (137), Expect = 7e-08
Identities = 73/333 (21%), Positives = 137/333 (40%), Gaps = 45/333 (13%)
Query: 111 SGQSNRAPPVPTKPKSIGLQHKGTGEKAQIIVGGSTSGTTHTINEEER---RAFTTHINS 167
SG + PP T P ++ L + + ++ + +E +R + FT +N
Sbjct: 31 SGSLSPCPPGDTLPWNLPLHEQKKRKSQDSVLDPAERAVVRVADERDRVQKKTFTKWVNK 90
Query: 168 VLAGDADIGHRLPFPTDTFQLFDECRDGLVLSKLINDSVPDTIDTRVLNWPK--NNKALN 225
H + L+++ RDG L L+ VL+ K K
Sbjct: 91 ---------HLMKVRKHINDLYEDLRDGHNLISLLE----------VLSGIKLPREKGRM 131
Query: 226 TFTASENANIVINSAKAIGCVVVNVHSEDIIEGKEHLILGLIWQIIRRGLLSKIDIKLHP 285
F +N I ++ K +VN+ ++DI +G L LGLIW II +S DI +
Sbjct: 132 RFHRLQNVQIALDFLKQRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQIS--DIYISG 189
Query: 286 ELYRLLEEDETLEQFLRLPPEQILLRWFNYHLKQAGWHRRVSNFSSDIKDGENYTVLLNQ 345
E D + ++ L L +++ + + +NFSS DG+ + L+++
Sbjct: 190 E-----SGDMSAKEKLLLWTQKVTAGYTGI---------KCTNFSSCWSDGKMFNALIHR 235
Query: 346 LDSNLCSLGPLQTTDLLERAEEVLQNAEKLECRKYLTPTALVAGNP--KLNLAFVAHLFN 403
+L + +Q E E+ + AE+L + L + +P K + +V+ +++
Sbjct: 236 YRPDLVDMERVQIQSNRENLEQAFEVAERLGVTRLLDAEDVDVPSPDEKSVITYVSSIYD 295
Query: 404 THPGLDPLDENEPIEIEDFDAE-GEREARVFTL 435
P + + E I + D+ E ++RV +L
Sbjct: 296 AFPKVP--EGGEGISATEVDSRWQEYQSRVDSL 326
>Hs15011904 [Z] KOG0516 Dystonin GAS (Growth-arrest-specific protein) and
related proteins
Length = 5430
Score = 75.9 bits (185), Expect = 2e-13
Identities = 68/249 (27%), Positives = 111/249 (44%), Gaps = 24/249 (9%)
Query: 411 LDENEPIEIEDFDAEGEREARVFTLWLNS--LEVDPPVVSLFEDLKDGLVLLQAYDKVIP 468
LD E + D + + FT W+N ++V + L+EDL+DG L+ + V+
Sbjct: 62 LDPAERAVVRVADERDRVQKKTFTKWVNKHLMKVRKHINDLYEDLRDGHNLISLLE-VLS 120
Query: 469 GSVNWKVINKKSSDSELSRFKALENTNYAVDLGKSRGFSLVGIDGSDIVDGNKLLTLGLV 528
G K + RF L+N A+D K R LV I DI DGN LTLGL+
Sbjct: 121 GI-------KLPREKGRMRFHRLQNVQIALDFLKQRQVKLVNIRNDDITDGNPKLTLGLI 173
Query: 529 WQLMRKNIVNTMNELATTGRDMSDSQILKWAQETVS--KGGKSSTIRS-FSDPSLSNAHF 585
W ++ ++ + +G + ++L W Q+ + G K + S +SD + NA
Sbjct: 174 WTIILHFQISDIYISGESGDMSAKEKLLLWTQKVTAGYTGIKCTNFSSCWSDGKMFNA-- 231
Query: 586 LLDVLNGLAPGYVDYSLVLPGKTEEDRYANARLAISIARKLGALIWLVPEDIN--EVRSR 643
+++ P VD V E N A +A +LG L ED++ +
Sbjct: 232 ---LIHRYRPDLVDMERVQIQSNRE----NLEQAFEVAERLGVTRLLDAEDVDVPSPDEK 284
Query: 644 LILTFVASL 652
++T+V+S+
Sbjct: 285 SVITYVSSI 293
Score = 57.4 bits (137), Expect = 7e-08
Identities = 73/333 (21%), Positives = 137/333 (40%), Gaps = 45/333 (13%)
Query: 111 SGQSNRAPPVPTKPKSIGLQHKGTGEKAQIIVGGSTSGTTHTINEEER---RAFTTHINS 167
SG + PP T P ++ L + + ++ + +E +R + FT +N
Sbjct: 31 SGSLSPCPPGDTLPWNLPLHEQKKRKSQDSVLDPAERAVVRVADERDRVQKKTFTKWVNK 90
Query: 168 VLAGDADIGHRLPFPTDTFQLFDECRDGLVLSKLINDSVPDTIDTRVLNWPK--NNKALN 225
H + L+++ RDG L L+ VL+ K K
Sbjct: 91 ---------HLMKVRKHINDLYEDLRDGHNLISLLE----------VLSGIKLPREKGRM 131
Query: 226 TFTASENANIVINSAKAIGCVVVNVHSEDIIEGKEHLILGLIWQIIRRGLLSKIDIKLHP 285
F +N I ++ K +VN+ ++DI +G L LGLIW II +S DI +
Sbjct: 132 RFHRLQNVQIALDFLKQRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQIS--DIYISG 189
Query: 286 ELYRLLEEDETLEQFLRLPPEQILLRWFNYHLKQAGWHRRVSNFSSDIKDGENYTVLLNQ 345
E D + ++ L L +++ + + +NFSS DG+ + L+++
Sbjct: 190 E-----SGDMSAKEKLLLWTQKVTAGYTGI---------KCTNFSSCWSDGKMFNALIHR 235
Query: 346 LDSNLCSLGPLQTTDLLERAEEVLQNAEKLECRKYLTPTALVAGNP--KLNLAFVAHLFN 403
+L + +Q E E+ + AE+L + L + +P K + +V+ +++
Sbjct: 236 YRPDLVDMERVQIQSNRENLEQAFEVAERLGVTRLLDAEDVDVPSPDEKSVITYVSSIYD 295
Query: 404 THPGLDPLDENEPIEIEDFDAE-GEREARVFTL 435
P + + E I + D+ E ++RV +L
Sbjct: 296 AFPKVP--EGGEGISATEVDSRWQEYQSRVDSL 326
>Hs5032283 [NTZ] KOG4286 Dystrophin-like protein
Length = 3685
Score = 74.7 bits (182), Expect = 4e-13
Identities = 72/246 (29%), Positives = 120/246 (48%), Gaps = 27/246 (10%)
Query: 418 EIEDFDAEGEREARVFTLWLN---SLEVDPPVVSLFEDLKDGLVLLQAYDKVIPGSVNWK 474
E+ED + + + FT W+N S + +LF DL+DG LL ++ G K
Sbjct: 6 EVEDCYEREDVQKKTFTKWVNAQFSKFGKQHIENLFSDLQDGRRLLD----LLEGLTGQK 61
Query: 475 VINKKSSDSELSRFKALENTNYAVDLGKSRGFSLVGIDGSDIVDGNKLLTLGLVWQ-LMR 533
+ +K S +R AL N N A+ + ++ LV I +DIVDGN LTLGL+W ++
Sbjct: 62 LPKEKGS----TRVHALNNVNKALRVLQNNNVDLVNIGSTDIVDGNHKLTLGLIWNIILH 117
Query: 534 KNIVNTM-NELATTGRDMSDSQILKWAQETVSKGGKSSTIR---SFSDPSLSNAHFLLDV 589
+ N M N +A + S+ +L W +++ + + I S+SD NA +
Sbjct: 118 WQVKNVMKNIMAGLQQTNSEKILLSWVRQSTRNYPQVNVINFTTSWSDGLALNA-----L 172
Query: 590 LNGLAPGYVDYSLVLPGKTEEDRYANARLAISIAR-KLGALIWLVPEDINEV--RSRLIL 646
++ P D++ V+ ++ R + A +IAR +LG L PED++ + IL
Sbjct: 173 IHSHRPDLFDWNSVVCQQSATQRLEH---AFNIARYQLGIEKLLDPEDVDTTYPDKKSIL 229
Query: 647 TFVASL 652
++ SL
Sbjct: 230 MYITSL 235
>Hs5032281 [NTZ] KOG4286 Dystrophin-like protein
Length = 3677
Score = 72.0 bits (175), Expect = 3e-12
Identities = 73/242 (30%), Positives = 118/242 (48%), Gaps = 30/242 (12%)
Query: 425 EGERE---ARVFTLWLN---SLEVDPPVVSLFEDLKDGLVLLQAYDKVIPGSVNWKVINK 478
E ERE + FT W+N S + +LF DL+DG LL ++ G K+ +
Sbjct: 2 EDEREDVQKKTFTKWVNAQFSKFGKQHIENLFSDLQDGRRLLD----LLEGLTGQKLPKE 57
Query: 479 KSSDSELSRFKALENTNYAVDLGKSRGFSLVGIDGSDIVDGNKLLTLGLVWQ-LMRKNIV 537
K S +R AL N N A+ + ++ LV I +DIVDGN LTLGL+W ++ +
Sbjct: 58 KGS----TRVHALNNVNKALRVLQNNNVDLVNIGSTDIVDGNHKLTLGLIWNIILHWQVK 113
Query: 538 NTM-NELATTGRDMSDSQILKWAQETVSKGGKSSTIR---SFSDPSLSNAHFLLDVLNGL 593
N M N +A + S+ +L W +++ + + I S+SD NA +++
Sbjct: 114 NVMKNIMAGLQQTNSEKILLSWVRQSTRNYPQVNVINFTTSWSDGLALNA-----LIHSH 168
Query: 594 APGYVDYSLVLPGKTEEDRYANARLAISIAR-KLGALIWLVPEDINEV--RSRLILTFVA 650
P D++ V+ ++ R + A +IAR +LG L PED++ + IL ++
Sbjct: 169 RPDLFDWNSVVCQQSATQRLEH---AFNIARYQLGIEKLLDPEDVDTTYPDKKSILMYIT 225
Query: 651 SL 652
SL
Sbjct: 226 SL 227
>Hs5032287 [NTZ] KOG4286 Dystrophin-like protein
Length = 3681
Score = 71.6 bits (174), Expect = 3e-12
Identities = 70/241 (29%), Positives = 117/241 (48%), Gaps = 27/241 (11%)
Query: 423 DAEGEREARVFTLWLN---SLEVDPPVVSLFEDLKDGLVLLQAYDKVIPGSVNWKVINKK 479
D + + + FT W+N S + +LF DL+DG LL ++ G K+ +K
Sbjct: 7 DEREDVQKKTFTKWVNAQFSKFGKQHIENLFSDLQDGRRLLD----LLEGLTGQKLPKEK 62
Query: 480 SSDSELSRFKALENTNYAVDLGKSRGFSLVGIDGSDIVDGNKLLTLGLVWQ-LMRKNIVN 538
S +R AL N N A+ + ++ LV I +DIVDGN LTLGL+W ++ + N
Sbjct: 63 GS----TRVHALNNVNKALRVLQNNNVDLVNIGSTDIVDGNHKLTLGLIWNIILHWQVKN 118
Query: 539 TM-NELATTGRDMSDSQILKWAQETVSKGGKSSTIR---SFSDPSLSNAHFLLDVLNGLA 594
M N +A + S+ +L W +++ + + I S+SD NA +++
Sbjct: 119 VMKNIMAGLQQTNSEKILLSWVRQSTRNYPQVNVINFTTSWSDGLALNA-----LIHSHR 173
Query: 595 PGYVDYSLVLPGKTEEDRYANARLAISIAR-KLGALIWLVPEDINEV--RSRLILTFVAS 651
P D++ V+ ++ R + A +IAR +LG L PED++ + IL ++ S
Sbjct: 174 PDLFDWNSVVCQQSATQRLEH---AFNIARYQLGIEKLLDPEDVDTTYPDKKSILMYITS 230
Query: 652 L 652
L
Sbjct: 231 L 231
>Hs4505877 [Z] KOG0516 Dystonin GAS (Growth-arrest-specific protein) and
related proteins
Length = 4574
Score = 69.7 bits (169), Expect = 1e-11
Identities = 67/250 (26%), Positives = 111/250 (43%), Gaps = 25/250 (10%)
Query: 411 LDENEPIEIEDFDAEGEREARVFTLWLNS--LEVDPPVVSLFEDLKDGLVLLQAYDKVIP 468
LD E I D + + FT W+N ++ + L+EDL+DG L+ + +
Sbjct: 53 LDPAERAVIRIADERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSG 112
Query: 469 GSVNWKVINKKSSDSELSRFKALENTNYAVDLGKSRGFSLVGIDGSDIVDGNKLLTLGLV 528
S+ + RF L+N A+D + R LV I DI DGN LTLGL+
Sbjct: 113 DSL--------PREKGRMRFHKLQNVQIALDYLRHRQVKLVNIRDDDIADGNPKLTLGLI 164
Query: 529 WQLMRKNIVNTMNELATTGRDMSDSQILKWAQETVS--KGGKSSTI-RSFSDPSLSNAHF 585
W ++ ++ + + + ++L W+Q V +G + S+ D L NA
Sbjct: 165 WTIILHFQISDIQVSGQSEDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNA-- 222
Query: 586 LLDVLNGLAPGYVDYSLVLPGKTEEDRYANARLAISIA-RKLGALIWLVPEDIN--EVRS 642
+++ P +D + V + N A S+A R LG L PED++ +
Sbjct: 223 ---IIHRHKPLLIDMNKVY----RQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDE 275
Query: 643 RLILTFVASL 652
+ I+T+V+SL
Sbjct: 276 KSIITYVSSL 285
Score = 51.2 bits (121), Expect = 5e-06
Identities = 66/312 (21%), Positives = 118/312 (37%), Gaps = 54/312 (17%)
Query: 111 SGQSNRAPPVPTKPKSIGLQHK------GTGEKAQIIVGGSTSGTTHTINEEER---RAF 161
+G S P T P ++G + G G ++ + +E +R + F
Sbjct: 17 NGSSGSPSPGDTLPWNLGKTQRSRRSGGGAGSNGSVL-DPAERAVIRIADERDRVQKKTF 75
Query: 162 TTHINSVLAGDADIGHRLPFPTDTFQLFDECRDG----LVLSKLINDSVPDTIDTRVLNW 217
T +N H + L+++ RDG +L L DS+P
Sbjct: 76 TKWVNK---------HLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLP---------- 116
Query: 218 PKNNKALNTFTASENANIVINSAKAIGCVVVNVHSEDIIEGKEHLILGLIWQIIRRGLLS 277
K F +N I ++ + +VN+ +DI +G L LGLIW II +S
Sbjct: 117 --REKGRMRFHKLQNVQIALDYLRHRQVKLVNIRDDDIADGNPKLTLGLIWTIILHFQIS 174
Query: 278 KIDIKLHPELYRLLEEDETLEQFLRLPPEQILLRWFNYHLKQAGWHRRVSNFSSDIKDGE 337
I + ED T ++ L L ++ + + R NF+S +DG
Sbjct: 175 DIQVSGQ-------SEDMTAKEKLLL---------WSQRMVEGYQGLRCDNFTSSWRDGR 218
Query: 338 NYTVLLNQLDSNLCSLGPLQTTDLLERAEEVLQNAEK-LECRKYLTPTALVAGNP--KLN 394
+ ++++ L + + LE ++ AE+ L + L P + P K
Sbjct: 219 LFNAIIHRHKPLLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSI 278
Query: 395 LAFVAHLFNTHP 406
+ +V+ L++ P
Sbjct: 279 ITYVSSLYDAMP 290
>Hs6005938 [NTZ] KOG4286 Dystrophin-like protein
Length = 3433
Score = 68.2 bits (165), Expect = 4e-11
Identities = 62/229 (27%), Positives = 104/229 (45%), Gaps = 36/229 (15%)
Query: 423 DAEGEREARVFTLWLN---SLEVDPPVVSLFEDLKDGLVLLQAYDKVIPGSVNWKVINKK 479
D + + + FT W+N S PP+ +F DLKDG LL ++ G + ++
Sbjct: 27 DEHNDVQKKTFTKWINARFSKSGKPPINDMFTDLKDGRKLLD----LLEGLTGTSLPKER 82
Query: 480 SSDSELSRFKALENTNYAVDLGKSRGFSLVGIDGSDIVDGNKLLTLGLVWQL-----MRK 534
S +R AL N N + + LV I G+DIVDGN LTLGL+W + ++
Sbjct: 83 GS----TRVHALNNVNRVLQVLHQNNVELVNIGGTDIVDGNHKLTLGLLWSIILHWQVKD 138
Query: 535 NIVNTMNELATTGRDMSDSQILKWAQETVSKGGKSSTIR---SFSDPSLSNAHFLLDVLN 591
+ + M++L T S+ +L W ++T + + + S++D NA VL+
Sbjct: 139 VMKDVMSDLQQTN---SEKILLSWVRQTTRPYSQVNVLNFTTSWTDGLAFNA-----VLH 190
Query: 592 GLAPGYVDYSLVL---PGKTEEDRYANARLAISIARKLGALIWLVPEDI 637
P + V+ P + E ++ A+ + I + L PED+
Sbjct: 191 RHKPDLFSWDKVVKMSPIERLEHAFSKAQTYLGIEKLLD------PEDV 233
>Hs4501893 [Z] KOG0035 Ca2+-binding actin-bundling protein (actinin) alpha
chain (EF-Hand protein superfamily)
Length = 894
Score = 67.0 bits (162), Expect = 9e-11
Identities = 68/253 (26%), Positives = 120/253 (46%), Gaps = 31/253 (12%)
Query: 412 DENE-PIEIEDFDAE-------GEREARVFTLWLNS--LEVDPPVVSLFEDLKDGLVLLQ 461
DE+E I+ E++D + +++ + FT W NS + + ++ ED ++GL L+
Sbjct: 15 DEDEYMIQEEEWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRNGLKLML 74
Query: 462 AYDKVIPGSVNWKVINKKSSDSELSRFKALENTNYAVDLGKSRGFSLVGIDGSDIVDGNK 521
+ VI G D RF + N N A+D S+G LV I +IVDGN
Sbjct: 75 LLE-VISGE------RLPKPDRGKMRFHKIANVNKALDYIASKGVKLVSIGAEEIVDGNV 127
Query: 522 LLTLGLVWQLMRKNIVNTMNELATTGRDMSDSQILKWAQETVSKGGKSSTIRSFSDPSLS 581
+TLG++W ++ + + ++ T+ ++ +L W Q + ++ I++F S
Sbjct: 128 KMTLGMIWTIILRFAIQDISVEETSAKE----GLLLWCQRKTAP-YRNVNIQNF-HTSWK 181
Query: 582 NAHFLLDVLNGLAPGYVDYSLVLPGKTEEDRYANARLAISIARK-LGALIWLVPEDI--- 637
+ L +++ P +DYS + ++D N LA+ IA K L L EDI
Sbjct: 182 DGLGLCALIHRHRPDLIDYSKL----NKDDPIGNINLAMEIAEKHLDIPKMLDAEDIVNT 237
Query: 638 NEVRSRLILTFVA 650
+ R I+T+V+
Sbjct: 238 PKPDERAIMTYVS 250
>CE21256 [Z] KOG0035 Ca2+-binding actin-bundling protein (actinin) alpha
chain (EF-Hand protein superfamily)
Length = 894
Score = 65.9 bits (159), Expect = 2e-10
Identities = 59/215 (27%), Positives = 100/215 (46%), Gaps = 26/215 (12%)
Query: 420 EDFDAEG-------EREARVFTLWLNS--LEVDPPVVSLFEDLKDGLVLLQAYDKVIPGS 470
E++D EG +++ + FT W NS + + ++ ED ++GL L+ + VI G
Sbjct: 23 EEWDREGLLDPAWEKQQKKTFTAWCNSHLRKAGTSIDTIEEDFRNGLKLMLLLE-VISGE 81
Query: 471 VNWKVINKKSSDSELSRFKALENTNYAVDLGKSRGFSLVGIDGSDIVDGNKLLTLGLVWQ 530
K D RF + N N A++ +S+G LV I +IVDGN +TLGL+W
Sbjct: 82 PLPK------PDRGKMRFHKIANVNKALEYIESKGVKLVSIGAEEIVDGNVKMTLGLIWT 135
Query: 531 LMRKNIVNTMNELATTGRDMSDSQILKWAQETVSKGGKSSTIRSFSDPSLSNAHFLLDVL 590
++ + + +N + RD +L W Q + + +++F + S + ++
Sbjct: 136 IILRFAIQDINVEELSARD----GLLLWCQRKTAP-YNNVNVQNFHN-SWKDGLAFCALI 189
Query: 591 NGLAPGYVDYSLVLPGKTEEDRYANARLAISIARK 625
+ P +DYS + G D N LA IA K
Sbjct: 190 HRHRPDLLDYSQLHKG----DPIHNLNLAFDIAEK 220
>CE06539 [Z] KOG0035 Ca2+-binding actin-bundling protein (actinin) alpha
chain (EF-Hand protein superfamily)
Length = 920
Score = 65.9 bits (159), Expect = 2e-10
Identities = 59/215 (27%), Positives = 100/215 (46%), Gaps = 26/215 (12%)
Query: 420 EDFDAEG-------EREARVFTLWLNS--LEVDPPVVSLFEDLKDGLVLLQAYDKVIPGS 470
E++D EG +++ + FT W NS + + ++ ED ++GL L+ + VI G
Sbjct: 23 EEWDREGLLDPAWEKQQKKTFTAWCNSHLRKAGTSIDTIEEDFRNGLKLMLLLE-VISGE 81
Query: 471 VNWKVINKKSSDSELSRFKALENTNYAVDLGKSRGFSLVGIDGSDIVDGNKLLTLGLVWQ 530
K D RF + N N A++ +S+G LV I +IVDGN +TLGL+W
Sbjct: 82 PLPK------PDRGKMRFHKIANVNKALEYIESKGVKLVSIGAEEIVDGNVKMTLGLIWT 135
Query: 531 LMRKNIVNTMNELATTGRDMSDSQILKWAQETVSKGGKSSTIRSFSDPSLSNAHFLLDVL 590
++ + + +N + RD +L W Q + + +++F + S + ++
Sbjct: 136 IILRFAIQDINVEELSARD----GLLLWCQRKTAP-YNNVNVQNFHN-SWKDGLAFCALI 189
Query: 591 NGLAPGYVDYSLVLPGKTEEDRYANARLAISIARK 625
+ P +DYS + G D N LA IA K
Sbjct: 190 HRHRPDLLDYSQLHKG----DPIHNLNLAFDIAEK 220
>CE25734 [Z] KOG0516 Dystonin GAS (Growth-arrest-specific protein) and
related proteins
Length = 1376
Score = 64.3 bits (155), Expect = 6e-10
Identities = 60/258 (23%), Positives = 106/258 (40%), Gaps = 39/258 (15%)
Query: 423 DAEGEREARVFTLWLNS--LEVDPPVVSLFEDLKDGLVLLQAYDKVIPGSVNWKVINKKS 480
D + + FT W+N + D + LF DL+DG L+ + + +
Sbjct: 74 DERDNVQKKTFTKWVNKHLSKTDHKIDDLFVDLRDGYALIALLEALTGERIQ-------- 125
Query: 481 SDSELSRFKALENTNYAVDLGKSRGFSLVGIDGSDIVDGNKLLTLGLVWQL--------- 531
++ +RF ++N Y +D K + LV I DIV+GN LTLGL+W +
Sbjct: 126 KENGYTRFHRIQNVQYCLDFLKKKNIKLVNIRPEDIVEGNGKLTLGLIWTIILNFQVSVI 185
Query: 532 -------------MRKNIVNTMNELATTGRDMSDSQ--ILKWAQETVSKGGKSSTIRSFS 576
M T ++++ G D + ++ +L+WA+ V+ G + +FS
Sbjct: 186 RQRLLLESSQHEQMSAKHTTTNSQVSLHGSDATSARDALLQWARR-VTAGYPRVNVNNFS 244
Query: 577 DPSLSNAHFLLDVLNGLAPGYVDYSLVLPGKTEEDRYANARLAISIARKLGALIWLVPED 636
F +L+ +D++ + N A + R+ G L ED
Sbjct: 245 SSWRDGLAFNA-ILHRYRSSAIDWNKISSDSVSNTERLNNAFA-AADREFGVERLLDAED 302
Query: 637 I--NEVRSRLILTFVASL 652
+ N + I+T+V+SL
Sbjct: 303 VDTNNPDEKSIITYVSSL 320
Score = 52.0 bits (123), Expect = 3e-06
Identities = 71/298 (23%), Positives = 116/298 (38%), Gaps = 43/298 (14%)
Query: 157 ERRAFTTHINSVLAGDADIGHRLPFPTDTFQLFDECRDGLVLSKLINDSVPDTIDTRVLN 216
+++ FT +N L+ H++ LF + RDG L L+ + I
Sbjct: 80 QKKTFTKWVNKHLS---KTDHKID------DLFVDLRDGYALIALLEALTGERI------ 124
Query: 217 WPKNNKALNTFTASENANIVINSAKAIGCVVVNVHSEDIIEGKEHLILGLIWQIIRRGLL 276
+ F +N ++ K +VN+ EDI+EG L LGLIW II +
Sbjct: 125 --QKENGYTRFHRIQNVQYCLDFLKKKNIKLVNIRPEDIVEGNGKLTLGLIWTIILNFQV 182
Query: 277 SKIDIKL------HPEL---YRLLEEDETLEQFLRLPPEQILLRWFNYHLKQAGWHR-RV 326
S I +L H ++ + +L LL+W AG+ R V
Sbjct: 183 SVIRQRLLLESSQHEQMSAKHTTTNSQVSLHGSDATSARDALLQW--ARRVTAGYPRVNV 240
Query: 327 SNFSSDIKDGENYTVLLNQ-----LDSNLCSLGPLQTTDLLERAEEVLQNAEKLECRKYL 381
+NFSS +DG + +L++ +D N S + T+ L A +E + L
Sbjct: 241 NNFSSSWRDGLAFNAILHRYRSSAIDWNKISSDSVSNTERLNNAFAAADREFGVE--RLL 298
Query: 382 TPTALVAGNP--KLNLAFVAHLFNTHPGLDPLDENEPIEIEDFDAEGEREARVFTLWL 437
+ NP K + +V+ L+N P E E ++ E EA + W+
Sbjct: 299 DAEDVDTNNPDEKSIITYVSSLYNALP-----HEPEMSRLQKVQEEYIEEAYEWREWV 351
>7303255 [Z] KOG0516 Dystonin GAS (Growth-arrest-specific protein) and
related proteins
Length = 5385
Score = 63.9 bits (154), Expect = 7e-10
Identities = 77/264 (29%), Positives = 117/264 (44%), Gaps = 51/264 (19%)
Query: 408 LDPLDENEPIEIEDFDAEGEREA---RVFTLWLNS--LEVDPPVVSLFEDLKDGLVLLQA 462
LDP D + I D ER+A + FT W+N + + VV LFEDL+DG LL
Sbjct: 21 LDPADR-AVLRIAD-----ERDAIQKKTFTKWVNKHLKKANRRVVDLFEDLRDGHNLLSL 74
Query: 463 YDKVIPGSVNWKVINKKSSDSELSRFKALENTNYAVDLGKSRGFSLVGIDGSDIVDGNKL 522
+ V+ G + RF L+N A+D + + LV I DIVDGN
Sbjct: 75 LE-VLSGE-------HLPREKGKMRFHMLQNAQMALDFLRYKKIKLVNIRAEDIVDGNPK 126
Query: 523 LTLGLVWQLMRKNIVNTMNELATTGRDMSDSQILKWAQETVSKGGKSSTIRSFSDPSLSN 582
LTLGL+W + I++ G++ + S A+E + + + ST R P +
Sbjct: 127 LTLGLIWTI----ILHFQISDIVVGKEDNVS-----AREALLRWARRSTARY---PGVRV 174
Query: 583 AHFLLDVLNGLA---------PGYVDYSLVLPGKTEEDRYANARLAIS---IARKLGALI 630
F +GLA P +D+ K DR RL + + ++ G
Sbjct: 175 NDFTSSWRDGLAFSALVHRNRPDLLDWR-----KARNDR-PRERLETAFHIVEKEYGVTR 228
Query: 631 WLVPEDI--NEVRSRLILTFVASL 652
L PED+ NE + ++T+++SL
Sbjct: 229 LLDPEDVDTNEPDEKSLITYISSL 252
>CE25957 [Z] KOG0516 Dystonin GAS (Growth-arrest-specific protein) and
related proteins
Length = 1078
Score = 63.5 bits (153), Expect = 1e-09
Identities = 70/301 (23%), Positives = 121/301 (39%), Gaps = 74/301 (24%)
Query: 408 LDPLDENEPIEIEDF--------DAEGEREARVFTLWLNS--LEVDPPVVSLFEDLKDGL 457
+DP D E ++ + D + + FT W+N + D +V LF DL+DG
Sbjct: 12 IDPSDAQEKDILDHYELNRGKFNDVRDTMQKKTFTKWVNKHLTKTDHTIVDLFVDLRDGF 71
Query: 458 VLLQAYDKVIPGSVNWKVINKKSSDSELSRFKALENTNYAVDLGKSRGFS---------- 507
L+ + + + ++ +RF ++N Y +D K + S
Sbjct: 72 ALIALLEALTGERIQ--------RENGYTRFHRIQNVQYCLDFLKMKNVSFLERQAEKKT 123
Query: 508 ----LVGIDGSDIVDGNKLLTLGLVW-----------------------QLMRKNIVNTM 540
LV I DIV+GN LTLGL+W Q K+ N+
Sbjct: 124 NIIKLVNIRPEDIVEGNGKLTLGLIWTIILNFQVSVIRQRLLLESSQHEQTNEKHTTNSQ 183
Query: 541 NELATTGRDMSDSQILKWAQETVSKGGKSSTI---RSFSDPSLSNAHFLLDVLNGLAPGY 597
+ + + + +L+WA+ T ++ + + I S+ D NA +++
Sbjct: 184 DSIHRSETTSARDALLQWAKRTTAEYPRGNVINFSNSWRDGLAFNA-----IIHRYRSSA 238
Query: 598 VDYSLVLPGKTEEDRYANA-RLAISIA---RKLGALIWLVPEDI--NEVRSRLILTFVAS 651
+D++ K D +N RL I+ A R+ G L ED+ N + I+T+V+S
Sbjct: 239 IDWN-----KINSDSVSNTERLNIAFAAADREFGVERLLDAEDVDTNNPDEKSIITYVSS 293
Query: 652 L 652
L
Sbjct: 294 L 294
>Hs5902122 [Z] KOG0517 Beta-spectrin
Length = 2390
Score = 62.0 bits (149), Expect = 3e-09
Identities = 64/235 (27%), Positives = 111/235 (47%), Gaps = 23/235 (9%)
Query: 427 EREA---RVFTLWLNS--LEVDPPVVSLFEDLKDGLVLLQAYDKVIPGSVNWKVINKKSS 481
EREA + FT W+NS V V L+ DL+DG LL+ + V+ G + K +
Sbjct: 54 EREAVQKKTFTKWVNSHLARVTCRVGDLYSDLRDGRNLLRLLE-VLSGEILPKPTKGRM- 111
Query: 482 DSELSRFKALENTNYAVDLGKSRGFSLVGIDGSDIVDGNKLLTLGLVWQLMRKNIVNTMN 541
R LEN + A+ K + L + DIVDGN LTLGLVW ++ + + ++
Sbjct: 112 -----RIHCLENVDKALQFLKEQKVHLENMGSHDIVDGNHRLTLGLVWTIILRFQIQDIS 166
Query: 542 ELATTGRDMSDSQ--ILKWAQETVSKGGKSSTIRSFSDPSLSNAHFLLDVLNGLAPGYVD 599
++ ++ +L W Q + G + + +F+ F +++ P +D
Sbjct: 167 VETEDNKEKKSAKDALLLWCQMKTA-GYPNVNVHNFTTSWRDGLAFNA-IVHKHRPDLLD 224
Query: 600 YSLVLPGKTEEDRYANARLAISIARK-LGALIWLVPEDIN--EVRSRLILTFVAS 651
+ + + + + N + A ++A K LG L PED+N + + I+T+VA+
Sbjct: 225 FESL----KKCNAHYNLQNAFNLAEKELGLTKLLDPEDVNVDQPDEKSIITYVAT 275
>Hs4557241 [Z] KOG0035 Ca2+-binding actin-bundling protein (actinin) alpha
chain (EF-Hand protein superfamily)
Length = 901
Score = 62.0 bits (149), Expect = 3e-09
Identities = 49/201 (24%), Positives = 94/201 (46%), Gaps = 19/201 (9%)
Query: 427 EREARVFTLWLNS--LEVDPPVVSLFEDLKDGLVLLQAYDKVIPGSVNWKVINKKSSDSE 484
+++ + FT W NS + + ++ ED ++GL L+ + VI G D
Sbjct: 45 KQQRKTFTAWCNSHLRKAGTQIENIEEDFRNGLKLMLLLE-VISGE------RLPRPDKG 97
Query: 485 LSRFKALENTNYAVDLGKSRGFSLVGIDGSDIVDGNKLLTLGLVWQLMRKNIVNTMNELA 544
RF + N N A+D S+G LV I +IVDGN +TLG++W ++ + + ++
Sbjct: 98 KMRFHKIANVNKALDFIASKGVKLVSIGAEEIVDGNLKMTLGMIWTIILRFAIQDISVEE 157
Query: 545 TTGRDMSDSQILKWAQETVSKGGKSSTIRSFSDPSLSNAHFLLDVLNGLAPGYVDYSLVL 604
T+ ++ +L W Q + ++ +++F S + L +++ P +DY+ +
Sbjct: 158 TSAKE----GLLLWCQRKTAP-YRNVNVQNF-HTSWKDGLALCALIHRHRPDLIDYAKL- 210
Query: 605 PGKTEEDRYANARLAISIARK 625
++D N A +A K
Sbjct: 211 ---RKDDPIGNLNTAFEVAEK 228
>CE27773 [Z] KOG0517 Beta-spectrin
Length = 4063
Score = 62.0 bits (149), Expect = 3e-09
Identities = 60/230 (26%), Positives = 106/230 (46%), Gaps = 21/230 (9%)
Query: 429 EARVFTLWLNSL--EVDPPVVSLFEDLKDGLVLLQAYDKVIPGSVNWKVINKKSSDSELS 486
+ + FT W NS +V LFED+ DG++L++ + +I G K +
Sbjct: 53 QKKTFTKWCNSFLNRASLEIVDLFEDVGDGIMLMKLLE-IISGDKLGKPNRGRM------ 105
Query: 487 RFKALENTNYAVDLGKSRGFSLVGIDGSDIVDGNKLLTLGLVWQLMRKNIVNTM---NEL 543
R + +EN N +D K + L I DI+D N+ L LGL+W ++ + ++T+ +E
Sbjct: 106 RVQKVENLNKVLDFLKKKKIQLENIGAEDILDRNERLILGLIWTIILRFQIDTIVIEDEE 165
Query: 544 ATTGRDMSDSQILKWAQETVSKGGKSSTIRSFSDPSLSNAHFLLDVLNGLAPGYVDYSLV 603
R + +L W Q + G + I +F+ S N +++ P VD++ +
Sbjct: 166 ERGERKHAKDALLLWCQRKTA-GYPNVRIENFT-TSWRNGLAFNALIHSHRPDLVDFNRL 223
Query: 604 LPGKTEEDRYANARLAISIA-RKLGALIWLVPEDINEVR--SRLILTFVA 650
P + N A +A +KL L ED++ R + I+T+V+
Sbjct: 224 NP----NEHVDNLNHAFDVAEKKLEIARLLDAEDVDVTRPDEKSIITYVS 269
Score = 58.2 bits (139), Expect = 4e-08
Identities = 57/198 (28%), Positives = 94/198 (46%), Gaps = 27/198 (13%)
Query: 188 LFDECRDGLVLSKLINDSVPDTIDTRVLNWPKNNKALNTFTASENANIVINSAKAIGCVV 247
LF++ DG++L KL+ D + K N+ EN N V++ K +
Sbjct: 75 LFEDVGDGIMLMKLLEIISGDKLG-------KPNRGRMRVQKVENLNKVLDFLKKKKIQL 127
Query: 248 VNVHSEDIIEGKEHLILGLIWQIIRRGLLSKIDIKLHPELYRLLEEDETLEQFLRLPPEQ 307
N+ +EDI++ E LILGLIW II R + I ++E++E E+ R +
Sbjct: 128 ENIGAEDILDRNERLILGLIWTIILRFQIDTI----------VIEDEE--ERGERKHAKD 175
Query: 308 ILLRWFNYHLKQAGW-HRRVSNFSSDIKDGENYTVLLNQLDSNLCS---LGPLQTTDLLE 363
LL W K AG+ + R+ NF++ ++G + L++ +L L P + D L
Sbjct: 176 ALLLW--CQRKTAGYPNVRIENFTTSWRNGLAFNALIHSHRPDLVDFNRLNPNEHVDNLN 233
Query: 364 RAEEVLQNAEKLECRKYL 381
A +V + +KLE + L
Sbjct: 234 HAFDVAE--KKLEIARLL 249
>7290243 [Z] KOG0035 Ca2+-binding actin-bundling protein (actinin) alpha
chain (EF-Hand protein superfamily)
Length = 915
Score = 62.0 bits (149), Expect = 3e-09
Identities = 62/244 (25%), Positives = 115/244 (46%), Gaps = 30/244 (12%)
Query: 420 EDFDAEG-------EREARVFTLWLNS--LEVDPPVVSLFEDLKDGLVLLQAYDKVIPGS 470
E+++ EG +++ + FT W NS + + ++ ED ++GL L+ + VI G
Sbjct: 18 EEWEREGLLDPAWEKQQKKTFTAWCNSHLRKAGTAIDNIEEDFRNGLKLMLLLE-VISGE 76
Query: 471 VNWKVINKKSSDSELSRFKALENTNYAVDLGKSRGFSLVGIDGSDIVDGNKLLTLGLVWQ 530
K D RF + N N A+D S+G LV I +IVDGN +TLG++W
Sbjct: 77 TLPK------PDRGKMRFHKIANVNKALDFIASKGVHLVSIGAEEIVDGNLKMTLGMIWT 130
Query: 531 LMRKNIVNTMNELATTGRDMSDSQILKWAQETVSKGGKSSTIRSFSDPSLSNAHFLLDVL 590
++ + + ++ T ++ +L W Q + K+ +++F S + ++
Sbjct: 131 IILRFAIQDISVEEMTAKE----GLLLWCQRKTAP-YKNVNVQNF-HLSFKDGLAFCALI 184
Query: 591 NGLAPGYVDYSLVLPGKTEEDRYANARLAISIARK-LGALIWLVPED-INEVR--SRLIL 646
+ P +DY+ + ++++ N A +A K L L P+D IN + R I+
Sbjct: 185 HRHRPDLIDYAKL----SKDNPLENLNTAFDVAEKYLDIPRMLDPDDLINTPKPDERAIM 240
Query: 647 TFVA 650
T+V+
Sbjct: 241 TYVS 244
>Hs13435161 [Z] KOG0517 Beta-spectrin
Length = 2559
Score = 61.2 bits (147), Expect = 5e-09
Identities = 66/235 (28%), Positives = 107/235 (45%), Gaps = 23/235 (9%)
Query: 427 EREA---RVFTLWLNS--LEVDPPVVSLFEDLKDGLVLLQAYDKVIPGSVNWKVINKKSS 481
EREA + FT W+NS V + L+ DL+DG VL + + V+ G + +
Sbjct: 58 EREAVQKKTFTKWVNSHLARVGCHIGDLYVDLRDGFVLTRLLE-VLSGEQLPRPTRGRM- 115
Query: 482 DSELSRFKALENTNYAVDLGKSRGFSLVGIDGSDIVDGNKLLTLGLVWQLMRKNIVNTMN 541
R +LEN + A+ K + L + DIVDGN LTLGLVW ++ + + +
Sbjct: 116 -----RIHSLENVDKALQFLKEQRVHLENVGSHDIVDGNHRLTLGLVWTIILRFQIQVIK 170
Query: 542 ELATTGRDMSDSQ--ILKWAQETVSKGGKSSTIRSFSDPSLSNAHFLLDVLNGLAPGYVD 599
R+ ++ +L W Q + G I++F+ F +++ P VD
Sbjct: 171 IETEDNRETRSAKDALLLWCQMKTA-GYPEVNIQNFTTSWRDGLAFNA-LIHRHRPDLVD 228
Query: 600 YSLVLPGKTEEDRYANARLAISIARK-LGALIWLVPEDIN--EVRSRLILTFVAS 651
+S + T+ + N + A A + LG L PED+N + I+T+V S
Sbjct: 229 FSKL----TKSNANYNLQRAFRTAEQHLGLARLLDPEDVNMEAPDEKSIITYVVS 279
Score = 50.8 bits (120), Expect = 6e-06
Identities = 51/219 (23%), Positives = 92/219 (41%), Gaps = 32/219 (14%)
Query: 157 ERRAFTTHINSVLAGDADIGHRLPFPTDTFQLFDECRDGLVLSKLINDSVPDTIDTRVLN 216
+++ FT +NS LA +G + L+ + RDG VL++L+ + +
Sbjct: 63 QKKTFTKWVNSHLAR---VGCHIG------DLYVDLRDGFVLTRLLEVLSGEQL------ 107
Query: 217 WPKNNKALNTFTASENANIVINSAKAIGCVVVNVHSEDIIEGKEHLILGLIWQIIRRGLL 276
P+ + + EN + + K + NV S DI++G L LGL+W II R +
Sbjct: 108 -PRPTRGRMRIHSLENVDKALQFLKEQRVHLENVGSHDIVDGNHRLTLGLVWTIILRFQI 166
Query: 277 SKIDIKLHPELYRLLEEDETLEQFLRLPPEQILLRWFNYHLKQAGWHR-RVSNFSSDIKD 335
I I ET + + LL W +K AG+ + NF++ +D
Sbjct: 167 QVIKI-------------ETEDNRETRSAKDALLLW--CQMKTAGYPEVNIQNFTTSWRD 211
Query: 336 GENYTVLLNQLDSNLCSLGPLQTTDLLERAEEVLQNAEK 374
G + L+++ +L L ++ + + AE+
Sbjct: 212 GLAFNALIHRHRPDLVDFSKLTKSNANYNLQRAFRTAEQ 250
>Hs4507193 [Z] KOG0517 Beta-spectrin
Length = 2106
Score = 60.8 bits (146), Expect = 6e-09
Identities = 61/239 (25%), Positives = 108/239 (44%), Gaps = 38/239 (15%)
Query: 429 EARVFTLWLNS--LEVDPPVVSLFEDLKDGLVLLQAYDKVIPGSVNWKVINKKSSDSELS 486
+ + FT W+NS V + L++DL+DG +L++ + V+ G + K K
Sbjct: 56 QKKTFTKWVNSHLARVSCRITDLYKDLRDGRMLIKLLE-VLSGEMLPKPTKGKM------ 108
Query: 487 RFKALENTNYAVDLGKSRGFSLVGIDGSDIVDGNKLLTLGLVWQLMRKNIVNTMNELATT 546
R LEN + A+ K + L + DIVDGN L LGL+W ++ + + +
Sbjct: 109 RIHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLVLGLIWTIILRFQIQDIVVQTQE 168
Query: 547 GRDMSDSQ--ILKWAQETVSKGGKSSTIRSFSDPSLSNAHFLLDVLNGLA---------P 595
GR+ ++ +L W Q +++ P ++ +F +GLA P
Sbjct: 169 GRETRSAKDALLLWCQ-----------MKTAGYPHVNVTNFTSSWKDGLAFNALIHKHRP 217
Query: 596 GYVDYSLVLPGKTEEDRYANARLAISIA-RKLGALIWLVPEDI--NEVRSRLILTFVAS 651
+D+ + K R+ N A ++A R+LG + L PED+ + I+T+V +
Sbjct: 218 DLIDFDKL---KDSNARH-NLEHAFNVAERQLGIIPLLDPEDVFTENPDEKSIITYVVA 272
Score = 60.5 bits (145), Expect = 8e-09
Identities = 65/237 (27%), Positives = 103/237 (43%), Gaps = 33/237 (13%)
Query: 157 ERRAFTTHINSVLAGDADIGHRLPFPTDTFQLFDECRDGLVLSKLINDSVPDTIDTRVLN 216
+++ FT +NS LA + R+ TD L+ + RDG +L KL+ + + +L
Sbjct: 56 QKKTFTKWVNSHLAR---VSCRI---TD---LYKDLRDGRMLIKLL-----EVLSGEML- 100
Query: 217 WPKNNKALNTFTASENANIVINSAKAIGCVVVNVHSEDIIEGKEHLILGLIWQIIRRGLL 276
PK K EN + + K + N+ S DI++G L+LGLIW II R +
Sbjct: 101 -PKPTKGKMRIHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLVLGLIWTIILRFQI 159
Query: 277 SKIDIKLHPELYRLLEEDETLEQFLRLPPEQILLRWFNYHLKQAGW-HRRVSNFSSDIKD 335
I + +T E + LL W +K AG+ H V+NF+S KD
Sbjct: 160 QDIVV-------------QTQEGRETRSAKDALLLW--CQMKTAGYPHVNVTNFTSSWKD 204
Query: 336 GENYTVLLNQLDSNLCSLGPLQTTDLLERAEEVLQNAEK-LECRKYLTPTALVAGNP 391
G + L+++ +L L+ ++ E AE+ L L P + NP
Sbjct: 205 GLAFNALIHKHRPDLIDFDKLKDSNARHNLEHAFNVAERQLGIIPLLDPEDVFTENP 261
>Hs4501891 [Z] KOG0035 Ca2+-binding actin-bundling protein (actinin) alpha
chain (EF-Hand protein superfamily)
Length = 892
Score = 59.7 bits (143), Expect = 1e-08
Identities = 60/231 (25%), Positives = 104/231 (44%), Gaps = 23/231 (9%)
Query: 427 EREARVFTLWLNS--LEVDPPVVSLFEDLKDGLVLLQAYDKVIPGSVNWKVINKKSSDSE 484
+++ + FT W NS + + ++ ED +DGL L+ + VI G K K
Sbjct: 31 KQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLE-VISGERLAKPERGKM---- 85
Query: 485 LSRFKALENTNYAVDLGKSRGFSLVGIDGSDIVDGNKLLTLGLVWQLMRKNIVNTMNELA 544
R + N N A+D S+G LV I +IVDGN +TLG++W ++ + + ++
Sbjct: 86 --RVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVEE 143
Query: 545 TTGRDMSDSQILKWAQETVSKGGKSSTIRSFSDPSLSNAHFLLDVLNGLAPGYVDYSLVL 604
T+ ++ +L W Q + K+ I++F F +++ P +DY +
Sbjct: 144 TSAKE----GLLLWCQRKTAP-YKNVNIQNFHISWKDGLGFCA-LIHRHRPELIDYGKL- 196
Query: 605 PGKTEEDRYANARLAISIARK-LGALIWLVPEDI---NEVRSRLILTFVAS 651
++D N A +A K L L EDI + I+T+V+S
Sbjct: 197 ---RKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSS 244
>Hs19923599 [Z] KOG0516 Dystonin GAS (Growth-arrest-specific protein) and
related proteins
Length = 1002
Score = 58.9 bits (141), Expect = 2e-08
Identities = 76/280 (27%), Positives = 116/280 (41%), Gaps = 56/280 (20%)
Query: 417 IEIEDFDAEGER-EARVFTLWLN-SLE-VDPP--VVSLFEDLKDGLVLLQAYDKVIPGSV 471
I +++ E E + R FT W+N LE +PP V LF D++DG +L+ A +V+ G
Sbjct: 21 IRVQNLQVERENVQKRTFTRWINLHLEKCNPPLEVKDLFVDIQDGKILM-ALLEVLSGR- 78
Query: 472 NWKVINKKSSDSELSRFKALENTNYAVDLGKSRGFSLVGIDGSDIVDGNKLLTLGLVWQL 531
++++ S S R L N A+ + LV ID ++I DGN L LGL+W +
Sbjct: 79 --NLLHEYKSSSH--RIFRLNNIAKALKFLEDSNVKLVSIDAAEIADGNPSLVLGLIWNI 134
Query: 532 ------------MRKNIVNTMNELATTGRDMSDS-----------------------QIL 556
+ +N ++ + G D S +L
Sbjct: 135 ILFFQIKELTGNLSRNSPSSSLSPGSGGTDSDSSFPPTPTAERSVAISVKDQRKAIKALL 194
Query: 557 KWAQETVSKGGKSSTIRSFSDPSLSNAHFLLDVLNGLAPGYVDYSLVLPGKTEEDRYANA 616
W Q K G + ++ F+ S FL V+ + P VD L T E N
Sbjct: 195 AWVQRKTRKYGVA--VQDFAGSWRSGLAFLA-VIKAIDPSLVDMKQALENSTRE----NL 247
Query: 617 RLAISIAR-KLGALIWLVPEDI--NEVRSRLILTFVASLM 653
A SIA+ L L PEDI + + I+T+VA +
Sbjct: 248 EKAFSIAQDALHIPRLLEPEDIMVDTPDEQSIMTYVAQFL 287
>ECU09g0290 [Z] KOG0035 Ca2+-binding actin-bundling protein (actinin) alpha
chain (EF-Hand protein superfamily)
Length = 565
Score = 58.9 bits (141), Expect = 2e-08
Identities = 65/233 (27%), Positives = 103/233 (43%), Gaps = 30/233 (12%)
Query: 429 EARVFTLWLNSLEV---DPPVVSLFEDLKDGLVLLQAYDKVIPGSVNWKVINKKSSDSEL 485
+ + FT W+N + + LF DL DG+ L Q + +V + + +
Sbjct: 13 QKKTFTKWVNEKLIRGGQKEIGDLFTDLCDGVKLAQLLMVLQKDAV-------EHNPTPY 65
Query: 486 SRFKALENTNYAVDLGKSRGFSLVGIDGSDIVDGNKLLTLGLVWQLMRKNIVNTMNELAT 545
+R + +EN + K + L+ I DIVDGN L LGL+W L+ + + + A
Sbjct: 66 TRIQKMENVERILSFIKGKRVKLINIGPQDIVDGNPKLILGLIWSLISRLAI---AKTAE 122
Query: 546 TGRDMSDSQILKWAQETVSKGGKSSTI----RSFSDPSLSNAHFLLDVLNGLAPGYVDYS 601
G +++L+W +E V+ G K+ I RS+ D NA + L P + D
Sbjct: 123 AGELSIRNELLRWCKE-VTSGYKNVNIADFSRSWRDGLAFNA-IIHRFRPDLVPNFHDL- 179
Query: 602 LVLPGKTEEDRYANARLAISIARK-LGALIWLVPEDINEVR---SRLILTFVA 650
+ E Y N A +A K LG L EDI EV + I+T+V+
Sbjct: 180 -----QASEKAY-NLNQAFKVAEKFLGIKRLLDVEDIVEVSIPDEKSIMTYVS 226
>Hs12025678 [Z] KOG0035 Ca2+-binding actin-bundling protein (actinin) alpha
chain (EF-Hand protein superfamily)
Length = 911
Score = 58.5 bits (140), Expect = 3e-08
Identities = 62/235 (26%), Positives = 108/235 (45%), Gaps = 31/235 (13%)
Query: 427 EREARVFTLWLNS--LEVDPPVVSLFEDLKDGLVLLQAYDKVIPGSVNWKVINKKSSDSE 484
+++ + FT W NS + + ++ ED +DGL L+ + VI G K K
Sbjct: 50 KQQRKTFTAWCNSHLRKAGTQIENIDEDFRDGLKLMLLLE-VISGERLPKPERGKM---- 104
Query: 485 LSRFKALENTNYAVDLGKSRGFSLVGIDGSDIVDGNKLLTLGLVWQLMRKNIVNTMNELA 544
R + N N A+D S+G LV I +IVDGN +TLG++W ++ + + ++
Sbjct: 105 --RVHKINNVNKALDFIASKGVKLVSIGAEEIVDGNAKMTLGMIWTIILRFAIQDISVEE 162
Query: 545 TTGRDMSDSQILKWAQETVSKGGKSSTIRSF----SDPSLSNAHFLLDVLNGLAPGYVDY 600
T+ ++ +L W Q + K+ +++F D NA +++ P ++Y
Sbjct: 163 TSAKE----GLLLWCQRKTAP-YKNVNVQNFHISWKDGLAFNA-----LIHRHRPELIEY 212
Query: 601 SLVLPGKTEEDRYANARLAISIARK-LGALIWLVPEDI-NEVR--SRLILTFVAS 651
+ ++D N A +A K L L EDI N R + I+T+V+S
Sbjct: 213 DKL----RKDDPVTNLNNAFEVAEKYLDIPKMLDAEDIVNTARPDEKAIMTYVSS 263
>Hs4507195 [Z] KOG0517 Beta-spectrin
Length = 2364
Score = 58.2 bits (139), Expect = 4e-08
Identities = 65/266 (24%), Positives = 119/266 (44%), Gaps = 39/266 (14%)
Query: 412 DENEPIEIEDFDAEG----------------EREA---RVFTLWLNS--LEVDPPVVSLF 450
D N +++D+D E EREA + FT W+NS V + L+
Sbjct: 20 DVNNRWDVDDWDNENSSARLFERSRIKALADEREAVQKKTFTKWVNSHLARVSCRITDLY 79
Query: 451 EDLKDGLVLLQAYDKVIPGSVNWKVINKKSSDSELSRFKALENTNYAVDLGKSRGFSLVG 510
DL+DG +L++ + V+ G K + R LEN + A+ K + L
Sbjct: 80 TDLRDGRMLIKLLE-VLSGERLPKPTKGRM------RIHCLENVDKALQFLKEQRVHLEN 132
Query: 511 IDGSDIVDGNKLLTLGLVWQLMRKNIVNTMNELATTGRDMSDSQ--ILKWAQETVSKGGK 568
+ DIVDGN LTLGL+W ++ + + ++ ++ ++ +L W Q + G
Sbjct: 133 MGSHDIVDGNHRLTLGLIWTIILRFQIQDISVETEDNKEKKSAKDALLLWCQMKTA-GYP 191
Query: 569 SSTIRSFSDPSLSNAHFLLDVLNGLAPGYVDYSLVLPGKTEEDRYANARLAISIARK-LG 627
+ I +F+ S + +++ P +D+ + + + + N + A ++A + LG
Sbjct: 192 NVNIHNFT-TSWRDGMAFNALIHKHRPDLIDFDKL----KKSNAHYNLQNAFNLAEQHLG 246
Query: 628 ALIWLVPEDI--NEVRSRLILTFVAS 651
L PEDI + + I+T+V +
Sbjct: 247 LTKLLDPEDISVDHPDEKSIITYVVT 272
Score = 53.9 bits (128), Expect = 8e-07
Identities = 59/237 (24%), Positives = 101/237 (41%), Gaps = 33/237 (13%)
Query: 157 ERRAFTTHINSVLAGDADIGHRLPFPTDTFQLFDECRDGLVLSKLINDSVPDTIDTRVLN 216
+++ FT +NS LA + R+ TD L+ + RDG +L KL+ + +
Sbjct: 56 QKKTFTKWVNSHLAR---VSCRI---TD---LYTDLRDGRMLIKLLEVLSGERL------ 100
Query: 217 WPKNNKALNTFTASENANIVINSAKAIGCVVVNVHSEDIIEGKEHLILGLIWQIIRRGLL 276
PK K EN + + K + N+ S DI++G L LGLIW II R +
Sbjct: 101 -PKPTKGRMRIHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLTLGLIWTIILRFQI 159
Query: 277 SKIDIKLHPELYRLLEEDETLEQFLRLPPEQILLRWFNYHLKQAGW-HRRVSNFSSDIKD 335
I + ET + + + LL W +K AG+ + + NF++ +D
Sbjct: 160 QDISV-------------ETEDNKEKKSAKDALLLW--CQMKTAGYPNVNIHNFTTSWRD 204
Query: 336 GENYTVLLNQLDSNLCSLGPLQTTDLLERAEEVLQNAEK-LECRKYLTPTALVAGNP 391
G + L+++ +L L+ ++ + AE+ L K L P + +P
Sbjct: 205 GMAFNALIHKHRPDLIDFDKLKKSNAHYNLQNAFNLAEQHLGLTKLLDPEDISVDHP 261
>Hs21553341 [Z] KOG0516 Dystonin GAS (Growth-arrest-specific protein) and
related proteins
Length = 6885
Score = 58.2 bits (139), Expect = 4e-08
Identities = 72/286 (25%), Positives = 118/286 (41%), Gaps = 59/286 (20%)
Query: 407 GLDPLDENEPIEIEDFDAEGEREARVFTLWLNSL---EVDPPVVS-LFEDLKDGLVLLQA 462
G+D L + E ED + + FT W+NS P V+S LF D+K G VLL
Sbjct: 17 GIDDLHISLQAEQED------TQKKAFTCWINSQLARHTSPSVISDLFTDIKKGHVLLDL 70
Query: 463 YDKVIPGSVNWKVINKKSSDSELSRFKALENTNYAVDLGKSRGFSLVGIDGSDIVDGNKL 522
+ V+ G + D + F+ N +A+ ++R L+ I +DI+DGN
Sbjct: 71 LE-VLSGQ-------QLPRDKGSNTFQCRINIEHALTFLRNRSIKLINIHVTDIIDGNPS 122
Query: 523 LTLGLVWQL--------MRKNIVNTMNELATTGRDMSDSQ-------------------- 554
+ LGL+W + + + + N+ + + DS
Sbjct: 123 IILGLIWTIILHFHIEKLAQTLSCNYNQPSLDDVSVVDSSPASSPPAKKCSKVQARWQMS 182
Query: 555 ----ILKWAQETVSKGGKSSTIRSFSDPSLSNAHFLLDVLNGLAPGYVDYSLVLPGKTEE 610
+L WAQE + +S + F S N L +++ L P +D V ++
Sbjct: 183 ARKALLLWAQEQCAT-YESVNVTDFKS-SWRNGMAFLAIIHALRPDLIDMKSVKHRSNKD 240
Query: 611 DRYANARLAISIA-RKLGALIWLVPEDINEV--RSRLILTFVASLM 653
N R A IA ++L L PED++ V + I+T+VA +
Sbjct: 241 ----NLREAFRIAEQELKIPRLLEPEDVDVVDPDEKSIMTYVAQFL 282
>7292359 [Z] KOG0517 Beta-spectrin
Length = 4097
Score = 57.8 bits (138), Expect = 5e-08
Identities = 60/232 (25%), Positives = 102/232 (43%), Gaps = 20/232 (8%)
Query: 429 EARVFTLWLNS--LEVDPPVVSLFEDLKDGLVLLQAYDKVIPGSVNWKVINKKSSDSELS 486
+ + FT W+NS ++ V LF DL DG+ LL+ + + + +S
Sbjct: 26 QKKTFTKWMNSFLIKAKMEVEDLFTDLADGIKLLKLLEIISSEKLG-------KPNSGRM 78
Query: 487 RFKALENTNYAVDLGKSRGFSLVGIDGSDIVDGNKLLTLGLVWQL-----MRKNIVNTMN 541
R +EN N ++ ++ L I DIVDGN L LGL+W + +++ ++
Sbjct: 79 RVHKIENVNKSLAFLHTK-VRLESIGAEDIVDGNPRLILGLIWTIILRFQIQEIEIDVDE 137
Query: 542 ELATTGRDMSDSQILKWAQETVSKGGKSSTIRSFSDPSLSNAHFLLDVLNGLAPGYVDYS 601
E ++ + + +L W Q + G I F++ S F +++ P +YS
Sbjct: 138 ENESSEKRSAKDALLLWCQRK-THGYPGVNITDFTNSWRSGLGFNA-LIHSHRPDLFEYS 195
Query: 602 LVLPGKTEEDRYANARLAISIARKLGALIWLVPEDINEVR--SRLILTFVAS 651
++ K N + A +LG L EDI+ R + ILT+VAS
Sbjct: 196 TIVNSKNSNLDNLNHAFD-TAANELGIPSLLDAEDIDSARPDEKSILTYVAS 246
>7291470 [Z] KOG0518 Actin-binding cytoskeleton protein filamin
Length = 1179
Score = 55.8 bits (133), Expect = 2e-07
Identities = 79/316 (25%), Positives = 117/316 (37%), Gaps = 64/316 (20%)
Query: 194 DGLVLSKLINDSVPDTIDTRVLNWPKNNKALNTFTASENANIVINSAKAIGCVVVNVHSE 253
DG L L+ + + TR L N + N ENA + S +A +VN+ +
Sbjct: 66 DGTCLCALV-----ENLQTRPLKPSWNRRPANQHHYLENATTALKSIEADHIKLVNIGNV 120
Query: 254 DIIEGKEHLILGLIWQIIRRGLLSKIDIKLHPELYRLLEEDETLEQFLRLPPEQILLRWF 313
DI+ G LILGLIW +I R + + + PP +++L W
Sbjct: 121 DIVNGNIKLILGLIWSLIVRYQIGR----------------------SKFPPRKLMLAWL 158
Query: 314 NYHLKQAGWHRRVSNFSSDIKDGENYTVLLNQLDSNLC----SLGPLQTTDLLERAEEVL 369
L R++N ++D G N LL+ L SL P Q+ +A ++
Sbjct: 159 QAALPDC----RITNLTTDWNSGVNLAALLDYCQPGLFPHWRSLDPSQSVRNCTQAMDLA 214
Query: 370 QNAEKLECRKYLTPTALVAGNPKLNLAFVAHLFNTHPGLDPLDENEPIEIEDFDAEGERE 429
Q + K L P L + P LD L + + F G
Sbjct: 215 Q--REFGVPKVLEPEYLAS-----------------PWLDEL--SGMTYLSYFMKPGGPG 253
Query: 430 ARVFTLWLNSLEVDPPVVSLFEDLKDGLVLLQAYDKVIPGSVNWKVINKKSSDSELSRFK 489
W+N+ +V PV + D DG V+ + K + GS K S+D F
Sbjct: 254 YNATMRWVNT-QVKDPVKNFTTDWNDGRVMCEII-KGLGGSA--PAPEKLSTDP----FH 305
Query: 490 ALENTNYAVDLGKSRG 505
N AVD G G
Sbjct: 306 YENNIRKAVDAGARLG 321
>CE28605 [Z] KOG0517 Beta-spectrin
Length = 2182
Score = 54.3 bits (129), Expect = 6e-07
Identities = 62/230 (26%), Positives = 102/230 (43%), Gaps = 20/230 (8%)
Query: 429 EARVFTLWLNS--LEVDPPVVSLFEDLKDGLVLLQAYDKVIPGSVNWKVINKKSSDSELS 486
+ + FT W+NS + V V L+ D++DG +LL+ V+ G K K
Sbjct: 42 QKKTFTKWVNSHLVRVSCKVQDLYMDMRDGKMLLRLL-AVLSGERLPKPTPGKM------ 94
Query: 487 RFKALENTNYAVDLGKSRGFSLVGIDGSDIVDGNKLLTLGLVWQ-LMRKNIVNTMNELAT 545
R LEN + +++ L + DIVDGN LTLGL+W ++R I + E A
Sbjct: 95 RIHCLENVEKGLQFLRNQHVHLENLGSHDIVDGNSRLTLGLIWTIILRFQIQDITFEDAD 154
Query: 546 TGRDMSDSQ-ILKWAQETVSKGGKSSTIRSFSDPSLSNAHFLLDVLNGLAPGYVDYSLVL 604
S + +L W Q + G + +++FS F +++ P VDY
Sbjct: 155 NHETRSAKEALLLWCQMKTA-GYPNVNVKNFSTSWRDGLAFNA-LIHKHRPDLVDYD--- 209
Query: 605 PGKTEEDRYANARLAISIA-RKLGALIWLVPEDIN--EVRSRLILTFVAS 651
+ + N + A A +LG +L ED+N + + I+T+V +
Sbjct: 210 -NLQKSNALYNLQSAFDTAENQLGLAKFLDAEDVNVDQPDEKSIITYVVT 258
>CE28604 [Z] KOG0517 Beta-spectrin
Length = 2257
Score = 54.3 bits (129), Expect = 6e-07
Identities = 62/230 (26%), Positives = 102/230 (43%), Gaps = 20/230 (8%)
Query: 429 EARVFTLWLNS--LEVDPPVVSLFEDLKDGLVLLQAYDKVIPGSVNWKVINKKSSDSELS 486
+ + FT W+NS + V V L+ D++DG +LL+ V+ G K K
Sbjct: 42 QKKTFTKWVNSHLVRVSCKVQDLYMDMRDGKMLLRLL-AVLSGERLPKPTPGKM------ 94
Query: 487 RFKALENTNYAVDLGKSRGFSLVGIDGSDIVDGNKLLTLGLVWQ-LMRKNIVNTMNELAT 545
R LEN + +++ L + DIVDGN LTLGL+W ++R I + E A
Sbjct: 95 RIHCLENVEKGLQFLRNQHVHLENLGSHDIVDGNSRLTLGLIWTIILRFQIQDITFEDAD 154
Query: 546 TGRDMSDSQ-ILKWAQETVSKGGKSSTIRSFSDPSLSNAHFLLDVLNGLAPGYVDYSLVL 604
S + +L W Q + G + +++FS F +++ P VDY
Sbjct: 155 NHETRSAKEALLLWCQMKTA-GYPNVNVKNFSTSWRDGLAFNA-LIHKHRPDLVDYD--- 209
Query: 605 PGKTEEDRYANARLAISIA-RKLGALIWLVPEDIN--EVRSRLILTFVAS 651
+ + N + A A +LG +L ED+N + + I+T+V +
Sbjct: 210 -NLQKSNALYNLQSAFDTAENQLGLAKFLDAEDVNVDQPDEKSIITYVVT 258
>7300519 [NTZ] KOG4286 Dystrophin-like protein
Length = 547
Score = 53.9 bits (128), Expect = 8e-07
Identities = 41/142 (28%), Positives = 62/142 (42%), Gaps = 13/142 (9%)
Query: 429 EARVFTLWLNSLEVDP---PVVSLFEDLKDGLVLLQAYDKVIPGSVNWKVINKKSSDSEL 485
+ + FT W+NS +D PV LF DL+DG LL + N K +
Sbjct: 21 QKKTFTKWINSHLIDTQCTPVKDLFLDLRDGHRLLALLSTLTQ-------TNLKPEKGRM 73
Query: 486 SRFKALENTNYAVDLGKSRGFSLVGIDGSDIVDGNKLLTLGLVWQLMRKNIVNTMNELAT 545
R + N N + + G LV I DIV GN LTLGL+W + + N + + +
Sbjct: 74 -RVHHINNLNKVITEIQQHGVKLVNISSDDIVGGNAKLTLGLIWLIALE--FNGQHLVKS 130
Query: 546 TGRDMSDSQILKWAQETVSKGG 567
+ + +L WA++ G
Sbjct: 131 HSSNGVEKSLLAWARQYTEPHG 152
>Hs4503745 [Z] KOG0518 Actin-binding cytoskeleton protein filamin
Length = 2647
Score = 52.8 bits (125), Expect = 2e-06
Identities = 41/131 (31%), Positives = 61/131 (46%), Gaps = 10/131 (7%)
Query: 407 GLDPLDENEPIEIEDF--DAEGER-EARVFTLWLNSLE--VDPPVVSLFEDLKDGLVLLQ 461
G+D D P +D DA ++ + FT W N V + +L DL DGL L+
Sbjct: 20 GVDTRDAEMPATEKDLAEDAPWKKIQQNTFTRWCNEHLKCVSKRIANLQTDLSDGLRLIA 79
Query: 462 AYDKVIPGSVNWKVINKKSSDSELSRFKALENTNYAVDLGKSRGFSLVGIDGSDIVDGNK 521
+ + + K +++K + R LEN + A++ LV ID IVDGN
Sbjct: 80 LLEVL-----SQKKMHRKHNQRPTFRQMQLENVSVALEFLDRESIKLVSIDSKAIVDGNL 134
Query: 522 LLTLGLVWQLM 532
L LGL+W L+
Sbjct: 135 KLILGLIWTLI 145
>7293373 [Z] KOG0517 Beta-spectrin
Length = 2291
Score = 52.4 bits (124), Expect = 2e-06
Identities = 44/157 (28%), Positives = 74/157 (47%), Gaps = 15/157 (9%)
Query: 427 EREA---RVFTLWLNS--LEVDPPVVSLFEDLKDGLVLLQAYDKVIPGSVNWKVINKKSS 481
ERE+ + FT W+NS V+ + L+ D++DG L++ + V+ G K K
Sbjct: 47 ERESVQKKTFTKWVNSHLCRVNCRIADLYVDMRDGKHLIKLLE-VLSGERLPKPTKGKM- 104
Query: 482 DSELSRFKALENTNYAVDLGKSRGFSLVGIDGSDIVDGNKLLTLGLVWQLMRKNIVN--T 539
R LEN + A+ + + L I DIVDGN L LGL+W ++ + + T
Sbjct: 105 -----RIHCLENVDKALQFLREQRVHLENIGSHDIVDGNASLNLGLIWTIILRFQIQDIT 159
Query: 540 MNELATTGRDMSDSQILKWAQETVSKGGKSSTIRSFS 576
+ E+ + +L W Q + G + +R+F+
Sbjct: 160 IEEVDNKETKSAKDALLLWCQMKTA-GYHNVNVRNFT 195
>CE04046 [Z] KOG0518 Actin-binding cytoskeleton protein filamin
Length = 874
Score = 51.6 bits (122), Expect = 4e-06
Identities = 70/307 (22%), Positives = 120/307 (38%), Gaps = 67/307 (21%)
Query: 232 NANIVINSAKAIGCVVVNVHSEDIIEGKEHLILGLIWQIIRRGLLSKIDIKLHPELYRLL 291
N + +++ + G VN+ S DI++G E LILGLIW +++R Y++
Sbjct: 75 NVQMALDALREDGVKTVNIGSHDIVDGNEKLILGLIWCLVQR--------------YQIA 120
Query: 292 EEDETLEQFLRLPPEQILLRWFNYHLKQAGWHRRVSNFSSDIKDGENYTVLLNQLDSNLC 351
+ ++PP+++++ W L + +++NF ++ DG + LL LC
Sbjct: 121 CK-------TKIPPKKLVMAWIQSALPEL----KLTNFRTNWNDGIALSALLEYCQPGLC 169
Query: 352 ----SLGPLQTTDLLERAEEVLQNAEKLECRKYLTPTALVAGNPKLNLAFVAHLFNTHPG 407
+L P + + RA L +YL +++ + HL + H
Sbjct: 170 PEWRNLDPSEARENCHRA--------LLLAERYLEVPPIISSD---------HLSSPH-- 210
Query: 408 LDPLDENEPIE-IEDFDAEGEREARVFTLWLNSLEVDPPVVSLFEDLKDGLVLLQAYDKV 466
LDE + + F +G R ++ L D V L DG +L +
Sbjct: 211 ---LDELSCLTYLSYFITKGAPGYRATLKKVSMLLPDCNVDDLEHSWSDGFLLAHLVE-- 265
Query: 467 IPGSVNWKVINKKSSDSELSRFKAL----ENTNYAVDLGKSRGF-SLVGIDGSDIVDGNK 521
+ + + E RF L EN +D G SL+G D G
Sbjct: 266 --------ICGGRVPELERMRFDNLNDFVENVAIVLDAAADIGVGSLIGADDIAEPQGEH 317
Query: 522 LLTLGLV 528
L T+ LV
Sbjct: 318 LGTMALV 324
Score = 51.2 bits (121), Expect = 5e-06
Identities = 32/106 (30%), Positives = 53/106 (49%), Gaps = 5/106 (4%)
Query: 429 EARVFTLWLNSLEVDPPVVSLFEDLKDGLVLLQAYDKVIPGSVNWKVINKKSSDSELSRF 488
+ FT W+N + L +DL DG+ L++ + ++ G + K D + +
Sbjct: 16 QLHTFTNWINEQLQGNVIRDLTQDLSDGVNLIKLVE-ILQGRRYYG----KVYDQDPTEI 70
Query: 489 KALENTNYAVDLGKSRGFSLVGIDGSDIVDGNKLLTLGLVWQLMRK 534
+ L N A+D + G V I DIVDGN+ L LGL+W L+++
Sbjct: 71 QKLMNVQMALDALREDGVKTVNIGSHDIVDGNEKLILGLIWCLVQR 116
>Hs4557597 [Z] KOG0518 Actin-binding cytoskeleton protein filamin
Length = 2705
Score = 50.8 bits (120), Expect = 6e-06
Identities = 42/162 (25%), Positives = 72/162 (43%), Gaps = 17/162 (10%)
Query: 231 ENANIVINSAKAIGCVVVNVHSEDIIEGKEHLILGLIWQIIRRGLLSKIDIKLHPELYRL 290
EN ++ + + +V++ S+ I++G LILGLIW +I LH +
Sbjct: 78 ENVSVALEFLEREHIKLVSIDSKAIVDGNLKLILGLIWTLI-----------LHYSISMP 126
Query: 291 LEEDETLEQFLRLPPEQILLRWFNYHLKQAGWHRRVSNFSSDIKDGENYTVLLNQLDSNL 350
+ EDE E + P+Q LL W + Q ++NF+ D +DG+ L++ L
Sbjct: 127 MWEDEDDEDARKQTPKQRLLGWIQNKVPQL----PITNFNRDWQDGKALGALVDNCAPGL 182
Query: 351 C-SLGPLQTTDLLERAEEVLQNAEK-LECRKYLTPTALVAGN 390
C +E + E +Q A+ L + + P +V N
Sbjct: 183 CPDWEAWDPNQPVENSREAMQQADDWLGVPQVIAPEEIVDPN 224
>CE18188 [Z] KOG0516 Dystonin GAS (Growth-arrest-specific protein) and
related proteins
Length = 814
Score = 50.4 bits (119), Expect = 8e-06
Identities = 33/116 (28%), Positives = 54/116 (46%), Gaps = 13/116 (11%)
Query: 429 EARVFTLWLN-SLEVDPP---VVSLFEDLKDGLVLLQAYDKVIPGSV--------NWKVI 476
+ FT W+N LE + LFED++DG++L + V+ G W+
Sbjct: 25 QKNTFTRWINFHLEEHSSSGRIEDLFEDIRDGVLLCHLIE-VLTGEALAPIHKLNYWEST 83
Query: 477 NKKSSDSELSRFKALENTNYAVDLGKSRGFSLVGIDGSDIVDGNKLLTLGLVWQLM 532
N R + N A+ + + RG L+ + +DI DGN + LGL+WQ++
Sbjct: 84 NAVHKGRVSKRVHHIANLTTALTVLRRRGLELINNNAADIADGNPRIVLGLIWQII 139
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.316 0.135 0.388
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 40,780,646
Number of Sequences: 60738
Number of extensions: 1848845
Number of successful extensions: 5631
Number of sequences better than 1.0e-05: 50
Number of HSP's better than 0.0 without gapping: 17
Number of HSP's successfully gapped in prelim test: 33
Number of HSP's that attempted gapping in prelim test: 5385
Number of HSP's gapped (non-prelim): 116
length of query: 657
length of database: 30,389,216
effective HSP length: 113
effective length of query: 544
effective length of database: 23,525,822
effective search space: 12798047168
effective search space used: 12798047168
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)