ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactVI5562 good L KOG1956 Replication, recombination and repair DNA topoisomerase III alpha
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactVI5562 1931937 1933913 659
(659 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YLR234w [L] KOG1956 DNA topoisomerase III alpha 680 0.0
SPBC16G5.12c [L] KOG1956 DNA topoisomerase III alpha 493 e-139
Hs10835218 [L] KOG1956 DNA topoisomerase III alpha 443 e-124
At5g63920 [L] KOG1956 DNA topoisomerase III alpha 399 e-111
CE28138 [L] KOG1956 DNA topoisomerase III alpha 397 e-110
7290697 [L] KOG1957 DNA topoisomerase III beta 329 7e-90
ECU04g1070 [L] KOG1956 DNA topoisomerase III alpha 325 1e-88
Hs4507635 [L] KOG1957 DNA topoisomerase III beta 319 7e-87
CE25309 [L] KOG1957 DNA topoisomerase III beta 305 2e-82
At2g32000 [L] KOG1957 DNA topoisomerase III beta 246 1e-64
At4g31210_2 [L] KOG1956 DNA topoisomerase III alpha 83 1e-15
>YLR234w [L] KOG1956 DNA topoisomerase III alpha
Length = 656
Score = 680 bits (1755), Expect = 0.0
Identities = 359/665 (53%), Positives = 464/665 (68%), Gaps = 31/665 (4%)
Query: 2 VKILCVAEKNSIAKNVAQILSGGRSSMRPSTSPYIKNYDFQYD-FQWLNMG-RCNVTMTA 59
+K+LCVAEKNSIAK V+QIL GGRS+ R S Y+KNYDF + F + G C VTMT+
Sbjct: 1 MKVLCVAEKNSIAKAVSQILGGGRSTSRDSGYMYVKNYDFMFSGFPFARNGANCEVTMTS 60
Query: 60 VAGHLMNLAFSQNEYGWGKCDPNLLFDAPTIDEMDD---KIVKNLQNEGRHATHLMIWTD 116
VAGHL + FS + +GWGKC LFDAP + M++ KI N++ E R+A +LMIWTD
Sbjct: 61 VAGHLTGIDFSHDSHGWGKCAIQELFDAPLNEIMNNNQKKIASNIKREARNADYLMIWTD 120
Query: 117 CDREGECIGWEIVQAXXXXXXXXXXXXXXYRAVFSHLEPSHIIASANRPRKLDQRQVDAV 176
CDREGE IGWEI Q YRAVFSHLE HI+ +A P +LD + V AV
Sbjct: 121 CDREGEYIGWEIWQEAKRGNRLIQNDQV-YRAVFSHLERQHILNAARNPSRLDMKSVHAV 179
Query: 177 RARQEIDLRAGLAFTRLLTGNYRSVLQSDLEY-KQLAK-----KDDKPVISYGTCQFPTL 230
R EIDLRAG+ FTRLLT R+ L++ K AK K+D V+SYGTCQFPTL
Sbjct: 180 GTRIEIDLRAGVTFTRLLTETLRNKLRNQATMTKDGAKHRGGNKNDSQVVSYGTCQFPTL 239
Query: 231 GFVVDRYERVINFIPEQFWHILLSVKDLDGSESKVKFQWERGHLFDRLAVLSIYEHCIGT 290
GFVVDR+ER+ NF+PE+FW+I L V++ D + FQW+RGHLFDRL+VL+ YE CI T
Sbjct: 240 GFVVDRFERIRNFVPEEFWYIQLVVENKDNGGTTT-FQWDRGHLFDRLSVLTFYETCIET 298
Query: 291 CEDRAKVIHVSSKDTKKFRPLPLTTVELQKNCSRFFKLSAKKTLDAAEKLYQQGYISYPR 350
+ A+V+ + SK T K+RPLPLTTVELQKNC+R+ +L+AK++LDAAEKLYQ+G+ISYPR
Sbjct: 299 AGNVAQVVDLKSKPTTKYRPLPLTTVELQKNCARYLRLNAKQSLDAAEKLYQKGFISYPR 358
Query: 351 TETDKFPAKTDLKSLLNKHQ--------GHSEWGPYVTNLMN-ENSTSTNKYQWPRSGNH 401
TETD FP DLKSL+ K G + W Y +L+ EN+++ NK+++PRSG+H
Sbjct: 359 TETDTFPHAMDLKSLVEKQAQLDQLAAGGRTAWASYAASLLQPENTSNNNKFKFPRSGSH 418
Query: 402 DDQAHPPIHPILCVDIAKTDNRMTSDEKTVYNYVVKHFLACCSTDARGRSTTLKLDWGGE 461
DD+AHPPIHPI+ + + ++ E+ VY YV +HFLACCS DA+G+S TL LDW E
Sbjct: 419 DDKAHPPIHPIVSLG---PEANVSPVERRVYEYVARHFLACCSEDAKGQSMTLVLDWAVE 475
Query: 462 TFYANGIQVLERNFLDIYQWADWKSNDTLPAYQMSDDVVVSKTEMKSGQTSPPKHMTESE 521
F A+G+ VLERNFLD+Y WA W++ LP +M+ V ++K EMK+G T+PPK MTESE
Sbjct: 476 RFSASGLVVLERNFLDVYPWARWETTKQLPRLEMNALVDIAKAEMKAGTTAPPKPMTESE 535
Query: 522 LIMLMDANGIGTDATIADHIEKIKSRNYIKVQTGSGSGAKKTASVFLPTSLGRSLVHGFE 581
LI+LMD NGIGTDATIA+HI+KI+ RNY++ S K+T PT+LG SLVHGFE
Sbjct: 536 LILLMDTNGIGTDATIAEHIDKIQVRNYVR----SEKVGKET--YLQPTTLGVSLVHGFE 589
Query: 582 KIGLEESFSKPFLRRDLEKDLQLICGGTKDKKDVVSLIIGMYRNYYQITTSQMRNLIKVY 641
IGLE+SF+KPF RR++E+DL+ IC G K DVV I+ YR Y+ T + L++VY
Sbjct: 590 AIGLEDSFAKPFQRREMEQDLKKICEGHASKTDVVKDIVEKYRKYWHKTNACKNTLLQVY 649
Query: 642 NDIKA 646
+ +KA
Sbjct: 650 DRVKA 654
>SPBC16G5.12c [L] KOG1956 DNA topoisomerase III alpha
Length = 622
Score = 493 bits (1270), Expect = e-139
Identities = 268/647 (41%), Positives = 396/647 (60%), Gaps = 41/647 (6%)
Query: 2 VKILCVAEKNSIAKNVAQILSGGRSSMRPSTSPYIKNYDFQYDFQWLNMGRCNVTMTAVA 61
+++LCVAEKNSIAK+VA IL GG R + S Y+KNYDF ++F N+G +VTMT+V+
Sbjct: 1 MRVLCVAEKNSIAKSVASILGGGHVRRRDTRSKYVKNYDFSFNFGG-NVGSSDVTMTSVS 59
Query: 62 GHLMNLAFSQNEYGWGKCDPNLLFDAPTIDEMD---DKIVKNLQNEGRHATHLMIWTDCD 118
GHL +F W ++LFDA I + + + N++ E R+A +L IWTDCD
Sbjct: 60 GHLTEASFPSEYSSWSSVPQDVLFDAQIITSVSKNAEVLADNIKKEARNAQYLYIWTDCD 119
Query: 119 REGECIGWEIVQAXXXXXXXXXXXXXXYRAVFSHLEPSHIIASANRPRKLDQRQVDAVRA 178
REGE IG EI RA F++LE SHII++A RPR + + DAV A
Sbjct: 120 REGEHIGVEISNVARASNPSIQVI----RADFNNLERSHIISAAKRPRDVSKNAADAVDA 175
Query: 179 RQEIDLRAGLAFTRLLTGNYRSVLQSDLEYKQLAKKDDKPVISYGTCQFPTLGFVVDRYE 238
R E+D R G FTRL T +Q + L K +ISYG CQFPTLGFVVDR++
Sbjct: 176 RIELDFRLGAIFTRLQT------IQLQKSFDILQNK----IISYGPCQFPTLGFVVDRWQ 225
Query: 239 RVINFIPEQFWHILLSVKDLDGSESK-VKFQWERGHLFDRLAVLSIYEHCIGTCEDRAKV 297
RV +F+PE +WH+ + +D + K ++F WER +FDRL + I E+C+ C+ AKV
Sbjct: 226 RVEDFVPETYWHL----RFVDKRQGKTIQFNWERAKVFDRLTTMIILENCL-ECKT-AKV 279
Query: 298 IHVSSKDTKKFRPLPLTTVELQKNCSRFFKLSAKKTLDAAEKLYQQGYISYPRTETDKFP 357
++++ K K++PLPL+TVEL K + ++SAKKTL+ AE LY G++SYPRTETD+F
Sbjct: 280 VNITQKPKTKYKPLPLSTVELTKLGPKHLRISAKKTLELAENLYTNGFVSYPRTETDQFD 339
Query: 358 AKTDLKSLLNKHQGHSEWGPYVTNLMNENSTSTNKYQWPRSGNHDDQAHPPIHPILCVDI 417
+ +L +++ K G EW Y L+ Y+ PR G H+D+AHPPIHP+ V
Sbjct: 340 SSMNLHAIIQKLTGAQEWDSYAEGLL------AGDYRPPRKGKHNDRAHPPIHPVQMVHR 393
Query: 418 AKTDNRMTSDEKTVYNYVVKHFLACCSTDARGRSTTLKLDWGGETFYANGIQVLERNFLD 477
+ ++ D VY + + FLACCS +A+G T +++ E F G+ V E+N+L+
Sbjct: 394 SALPSQ---DHWKVYELITRRFLACCSDNAKGAETLVQVKMEEELFSKKGLLVTEKNYLE 450
Query: 478 IYQWADWKSNDTLPAYQMSDDVVVSKTEMKSGQTSPPKHMTESELIMLMDANGIGTDATI 537
+Y + W+S+D LP Y++ ++ +M TS P ++TE ELI LMDANGIGTDAT+
Sbjct: 451 VYPYEKWESSDQLPEYRLHEEFQPHILDMMDSSTSSPSYITEPELIALMDANGIGTDATM 510
Query: 538 ADHIEKIKSRNYIKVQTGSGSGAKKTASVFLPTSLGRSLVHGFEKIGLEESFSKPFLRRD 597
A+HIEK++ R Y+ + G G + F+P+SLG +L G+++IGLE S +KPFLR++
Sbjct: 511 AEHIEKVQEREYVIKRKKRGQGVTE----FVPSSLGVALAKGYDEIGLEWSLTKPFLRKE 566
Query: 598 LEKDLQLICGGTKDKKDVVSLIIGMYRNYYQITTSQ---MRNLIKVY 641
+E L+ I G ++ +V +I+ +R+ + +T + ++N +VY
Sbjct: 567 MEVQLKNIENGQLNRNVLVHMILTQFRDVFHLTKQRFDCLKNSCRVY 613
>Hs10835218 [L] KOG1956 DNA topoisomerase III alpha
Length = 1001
Score = 443 bits (1140), Expect = e-124
Identities = 258/638 (40%), Positives = 359/638 (55%), Gaps = 48/638 (7%)
Query: 3 KILCVAEKNSIAKNVAQILSGGRSSMRPSTSPYIKNYDFQYDFQWLNMGRCNVTMTAVAG 62
K+LCVAEKN AK +A +LS GR R S + K Y+F Y N+ + MT+V+G
Sbjct: 35 KVLCVAEKNDAAKGIADLLSNGRMRRREGLSKFNKIYEFDYHLYGQNV---TMVMTSVSG 91
Query: 63 HLMNLAFSQNEYGWGKCDPNLLFDAPTIDEMDDKIV---KNLQNEGRHATHLMIWTDCDR 119
HL+ F W C+P +LF+A + V K L+ E R L+IWTDCDR
Sbjct: 92 HLLAHDFQMQFRKWQSCNPLVLFEAEIEKYCPENFVDIKKTLERETRQCQALVIWTDCDR 151
Query: 120 EGECIGWEIVQAXXXXXXXXXXXXXXYRAVFSHLEPSHIIASANRPRKLDQRQVDAVRAR 179
EGE IG+EI+ RA FS + P + + + DQR DAV R
Sbjct: 152 EGENIGFEIIHVCKAVKPNLQVL----RARFSEITPHAVRTACENLTEPDQRVSDAVDVR 207
Query: 180 QEIDLRAGLAFTRLLTGNYRSVLQSDLEYKQLAKKDDKPVISYGTCQFPTLGFVVDRYER 239
QE+DLR G AFTR T + + L + +ISYG+CQFPTLGFVV+R++
Sbjct: 208 QELDLRIGAAFTRFQTLRLQRIFPEVLA---------EQLISYGSCQFPTLGFVVERFKA 258
Query: 240 VINFIPEQFWHILLSVKDLDGSESKVKFQWERGHLFDRLAVLSIYEHCIGTCEDRAKVIH 299
+ F+PE F I ++ DG V+F W+R LF+ A L +Y+ C+ + A V+
Sbjct: 259 IQAFVPEIFHRIKVTHDHKDGI---VEFNWKRHRLFNHTACLVLYQLCVE--DPMATVVE 313
Query: 300 VSSKDTKKFRPLPLTTVELQKNCSRFFKLSAKKTLDAAEKLYQQGYISYPRTETDKFPAK 359
V SK K+RP L TVEL+K SR +++AK+T+ AEKLY QGYISYPRTET+ FP
Sbjct: 314 VRSKPKSKWRPQALDTVELEKLASRKLRINAKETMRIAEKLYTQGYISYPRTETNIFPRD 373
Query: 360 TDLKSLLNKHQGHSEWGPYVTNLMNENSTSTNKYQWPRSGNHDDQAHPPIHPILCVDIAK 419
+L L+ + WG + +++ + PR+GN DQAHPPIHP K
Sbjct: 374 LNLTVLVEQQTPDPRWGAFAQSILERGGPT------PRNGNKSDQAHPPIHP------TK 421
Query: 420 TDNRMTSDEKTVYNYVVKHFLACCSTDARGRSTTLKLDWGGETFYANGIQVLERNFLDIY 479
N + DE+ +Y ++V+HFLACCS DA+G+ TT+++D E F A+G+ +L RN+LD+Y
Sbjct: 422 YTNNLQGDEQRLYEFIVRHFLACCSQDAQGQETTVEIDIAQERFVAHGLMILARNYLDVY 481
Query: 480 QWADWKSNDTLPAYQMSDDVVVSKTEMKSGQTSPPKHMTESELIMLMDANGIGTDATIAD 539
+ W S+ LP Y+ S EM G+TSPPK +TE++LI LM+ +GIGTDAT A+
Sbjct: 482 PYDHW-SDKILPVYEQGSHFQPSTVEMVDGETSPPKLLTEADLIALMEKHGIGTDATHAE 540
Query: 540 HIEKIKSRNYIKVQTGSGSGAKKTASVFLPTSLGRSLVHGFEKIGLEESFSKPFLRRDLE 599
HIE IK+R Y+ + FLP LG LV G++ +G E SKP LR +LE
Sbjct: 541 HIETIKARMYVGLTPDKR---------FLPGHLGMGLVEGYDSMGYE--MSKPDLRAELE 589
Query: 600 KDLQLICGGTKDKKDVVSLIIGMYRNYYQITTSQMRNL 637
DL+LIC G KDK V+ + Y+ + ++ + L
Sbjct: 590 ADLKLICDGKKDKFVVLRQQVQKYKQVFIEAVAKAKKL 627
>At5g63920 [L] KOG1956 DNA topoisomerase III alpha
Length = 926
Score = 399 bits (1026), Expect = e-111
Identities = 246/668 (36%), Positives = 365/668 (53%), Gaps = 49/668 (7%)
Query: 2 VKILCVAEKNSIAKNVAQILSGGRSSMRPSTSPYIKNYDFQYDFQWLNMGRCNVTMTAVA 61
V +L VAEK S+AK+VA ILS G R S Y K ++F Y +N C + MT+V
Sbjct: 9 VTVLNVAEKPSVAKSVAGILSRGTFRTREGRSRYNKIFEFDYA---INGQPCRMLMTSVI 65
Query: 62 GHLMNLAFSQNEYGWGKCDPNLLFDAPTIDEM-DDK--IVKNLQNEGRHATHLMIWTDCD 118
GHLM L F+ W CDP L+ AP + + +DK I K L+ E R + L++W DCD
Sbjct: 66 GHLMELEFADRYRKWHSCDPADLYQAPVMKHVPEDKKDIKKTLEEEARKSDWLVLWLDCD 125
Query: 119 REGECIGWEIVQAXXXXXXXXXXXXXXYRAVFSHLEPSHIIASANRPRKLDQRQVDAVRA 178
REGE I +E+V RA FS L I + R +Q +AV A
Sbjct: 126 REGENIAFEVVDVCRAVKHNLFIR----RAHFSALIDRDIHEAVQNLRDPNQLFAEAVDA 181
Query: 179 RQEIDLRAGLAFTRLLTGNYRSVLQSDLEYKQLAKKDDKPVISYGTCQFPTLGFVVDRYE 238
RQEIDLR G +FTR T R D ++ ++ VISYG CQFPTLGF+V+RY
Sbjct: 182 RQEIDLRIGASFTRFQTMLLRDRFAIDSTGEERSR-----VISYGPCQFPTLGFIVERYW 236
Query: 239 RVINFIPEQFWHILLSVKDLDGSESKVKFQWERGHLFDRLAVLSIYEHCIGTCEDRAKVI 298
+ PE+FW I S + +G + F W RGHLFD + + +YE C+ E A V+
Sbjct: 237 EIQAHEPEEFWTINCSHQSEEGLAT---FNWMRGHLFDYASAVILYEMCVE--EPTATVM 291
Query: 299 HVSS-KDTKKFRPLPLTTVELQKNCSRFFKLSAKKTLDAAEKLYQQGYISYPRTETDKFP 357
+V ++ K+ P PL T+EL+K SR+F+LS++ T+ AE+LYQ G+ISYPRTETD F
Sbjct: 292 NVPHPRERFKYPPYPLNTIELEKRASRYFRLSSEHTMKVAEELYQAGFISYPRTETDSFS 351
Query: 358 AKTDLKSLLNKHQGHSEWGPYVTNLMNENSTSTNKYQWPRSGNHDDQAHPPIHPILCVDI 417
++TDL++++ + H WG Y L+ ++ P +G HDD+AHPPIHP
Sbjct: 352 SRTDLRAMVEEQTRHPAWGSYAQRLLEPEG---GLWRNPANGGHDDKAHPPIHP---TKF 405
Query: 418 AKTDNRMTSDEKTVYNYVVKHFLACCSTDARGRSTTLKLDWGGETFYANGIQVLERNFLD 477
+ ++ + D VY VV+H+LAC S A TT+++D GE F A+G +L +N+L+
Sbjct: 406 SSGESNWSRDHLNVYELVVRHYLACVSQPAVAAETTVEIDIAGERFSASGRAILAKNYLE 465
Query: 478 IYQWADWKSNDTLPAYQMSDDVVVSKTEMKSGQTSPPKHMTESELIMLMDANGIGTDATI 537
+Y++ W +P Y+ + + + + T PP + E++L+ MD GIGTDAT+
Sbjct: 466 VYRFESW-GGSVIPVYEKGQQFIPTTLTLDAAVTRPPPLLCEADLLSCMDKAGIGTDATM 524
Query: 538 ADHIEKIKSRNYIKVQTGSGSGAKKTASVFLPTSLGRSLVHGFEKIGLEESFSKPFLRRD 597
DHI+K+ R Y K + F PT+LG +LV G++ +G E KP LR
Sbjct: 525 HDHIKKLLDRGY---------ATKDANTRFSPTNLGEALVMGYDDMGYE--LWKPNLRAL 573
Query: 598 LEKDLQLICGGTKDKKDVVSLIIGMYRNYY---QITTSQMRNLIKVY-----NDIKAESQ 649
+E D+ + G K K +V+ + + + ++ S++ + ++ N ++ESQ
Sbjct: 574 MEHDMNEVSVGRKTKAEVLETCLQQMKACFLDARVKKSKLLEAMTIFFERSNNTDESESQ 633
Query: 650 --GQVTQR 655
G+V +R
Sbjct: 634 TAGEVVRR 641
>CE28138 [L] KOG1956 DNA topoisomerase III alpha
Length = 759
Score = 397 bits (1020), Expect = e-110
Identities = 243/627 (38%), Positives = 352/627 (55%), Gaps = 43/627 (6%)
Query: 1 MVKILCVAEKNSIAKNVAQILSGGRSSMRPSTSPYIKNYDFQYDFQWLNMGRCNVTMTAV 60
M + L VAEKN +AK VA ILS G ++ R S + K Y + L + +++T+V
Sbjct: 1 MKRALFVAEKNDVAKGVAAILSNGTANRREGRSKFNKIYTLNTE---LFGQQTAISVTSV 57
Query: 61 AGHLMNLAFSQNEYGWGKCDPNLLFDAPTIDEMDDK---IVKNLQNEGRHATHLMIWTDC 117
+GH+MN F +N W LF AP + + I + L+ + + L++WTDC
Sbjct: 58 SGHMMNFQFHENMSNWQTASMVELFRAPVRHVVTPEMKLIEQTLREQAQRHDILVVWTDC 117
Query: 118 DREGECIGWEIVQAXXXXXXXXXXXXXXYRAVFSHLEPSHIIASANRPRKLDQRQVDAVR 177
DREGE IG EIV+ +RA FS + + I +A +LD++ V AV
Sbjct: 118 DREGEAIGAEIVKVCRDSNRRLDI----FRARFSEITKAAITRAARNLIRLDEKTVAAVD 173
Query: 178 ARQEIDLRAGLAFTRLLTGNYRSVLQSDLEYKQLAKKDDKPVISYGTCQFPTLGFVVDRY 237
R E+DLR G AFTRL T + R+ + DL L + D VISYG+CQFPTLGFV DRY
Sbjct: 174 CRSELDLRIGSAFTRLQTLHLRNRFR-DL----LGQNDTSQVISYGSCQFPTLGFVTDRY 228
Query: 238 ERVINFIPEQFWHILLSVKDLDGSESKVKFQWERGHLFDRLAVLSIYEHCIGTCEDRAKV 297
+ + NF+ E FW +++ + KV+F W+R LFDR V +++ C T E A V
Sbjct: 229 KMIENFVSEPFWKLIV---EHTRESHKVEFLWDRNRLFDRDTVDILHDECKETKE--AHV 283
Query: 298 IHVSSKDTKKFRPLPLTTVELQKNCSRFFKLSAKKTLDAAEKLYQQGYISYPRTETDKFP 357
V+ K K+RP L TVEL+K ++SAK+T+ AEKLY +G+ISYPRTET+KFP
Sbjct: 284 EKVAKKPKSKWRPQALDTVELEKLGISKLRMSAKQTMQVAEKLYSKGFISYPRTETNKFP 343
Query: 358 AKTDLKSLLNKHQGHSEWGPYVTNLMNENSTSTNKYQWPRSGNHDDQAHPPIHPILCVDI 417
A +L L+ + + WG + ++ PR+G D+AHPPIHP+ +
Sbjct: 344 AGLNLTPLVQQQTQSNIWGDFANEVLQNGVN-------PRNGRKSDEAHPPIHPLKFTE- 395
Query: 418 AKTDNRMTSDEKTVYNYVVKHFLACCSTDARGRSTTLKLDWGGETFYANGIQVLERNFLD 477
+++ D+ VY VV+HFLAC S DA+G T + L G E F+A+G+++ + +L
Sbjct: 396 ---KHQLQGDDWKVYELVVRHFLACVSQDAQGEETMVNLTVGTEKFHASGLRIRDMGYLK 452
Query: 478 IYQWADWKSNDTLPAYQMSDDVVVSKTEMKSGQTSPPKHMTESELIMLMDANGIGTDATI 537
+Y + W N LP Y + + ++ G+T P +TE++LI LMD GIGTDAT
Sbjct: 453 VYVYEKW-GNRLLPTYTEGERFTDFELKIGDGKTQAPDFLTEADLISLMDKYGIGTDATH 511
Query: 538 ADHIEKIKSRNYIKVQTGSGSGAKKTASVFLPTSLGRSLVHGFEKIGLEESFSKPFLRRD 597
A+HIEKIK+R YI V + +P+ LG +LV G++ +G + SKP LR +
Sbjct: 512 AEHIEKIKTREYIGV---------RPDGKLIPSFLGLALVDGYDDMGF--AMSKPDLRAN 560
Query: 598 LEKDLQLICGGTKDKKDVVSLIIGMYR 624
LE L+ IC G + K++V+ IG YR
Sbjct: 561 LEIGLKEICDGRRQKQEVLDEQIGKYR 587
>7290697 [L] KOG1957 DNA topoisomerase III beta
Length = 875
Score = 329 bits (844), Expect = 7e-90
Identities = 220/660 (33%), Positives = 338/660 (50%), Gaps = 60/660 (9%)
Query: 1 MVKILCVAEKNSIAKNVAQILSGGRSSMRPSTSPYIKNYDFQYDFQWLNMGRCNVTMTAV 60
M +L VAEK S+A ++A ILS GR + + T +++ +F+ N G + MT+V
Sbjct: 1 MKSVLMVAEKPSLAASLAGILSNGRCTAKRGTGNGCSTHEWTGNFR--NEGSVHFRMTSV 58
Query: 61 AGHLMNLAFSQNEYGWGKCDPNLLFDAPTIDEMDD---KIVKNLQNEGRHATHLMIWTDC 117
GH+M+L F++ W K DP LF T + + + K L +E R +L++W DC
Sbjct: 59 CGHVMSLDFNKKYNCWDKVDPIQLFGCATEKKETNPKQNMRKFLAHEARGCDYLVLWLDC 118
Query: 118 DREGECIGWEIVQAXXXXXXXXXXXXXXYRAVFSHLEPSHIIASANRPRKLDQRQVDAVR 177
D+EGE I +E++ A YRA FS + I + ++ + +V
Sbjct: 119 DKEGENICFEVMDAVKHVINNVYSDQVTYRAHFSAITEKDIKKAMETLGHPNENEAKSVD 178
Query: 178 ARQEIDLRAGLAFTRLLTGNYRSVLQSDLEYKQLAKKDDKPVISYGTCQFPTLGFVVDRY 237
ARQE+DLR G AFTR T ++ Y L D +ISYG CQ PTLGF V R+
Sbjct: 179 ARQELDLRIGCAFTRFQTKFFQD------RYGDL----DSSLISYGPCQTPTLGFCVKRH 228
Query: 238 ERVINFIPEQFWHILLSVKDLDGSESKVKFQWERGHLFDR-LAVL---SIYEHCIGTCED 293
+ + F PE FWH+ L + +V +W RG +F + +A++ + EH
Sbjct: 229 DDIQTFKPESFWHLQLLA-----GQPEVTLEWARGRVFKKDIAIMLLNRVKEH------K 277
Query: 294 RAKVIHVSSKDTKKFRPLPLTTVELQKNCSRFFKLSAKKTLDAAEKLYQQGYISYPRTET 353
+A V V+SK+ K +P L TVEL + CS + + + AE+LY QGYISYPRTET
Sbjct: 278 KATVESVASKEAYKSKPQALNTVELMRICSSGLGIGPFQAMQIAERLYTQGYISYPRTET 337
Query: 354 DKFPAKTDLKSLLNKHQGHSEWGPYVTNLMNENSTSTNKYQWPRSGNHDDQAHPPIHPIL 413
+++P DL ++L+ + +++G +++ + T PR G D HPPI P+
Sbjct: 338 NQYPTNFDLPAVLHVLKPSADFGEEARSILGDIQT-------PRKGK-DAGDHPPITPM- 388
Query: 414 CVDIAKTDNRMTSDEKT--VYNYVVKHFLACCSTDARGRSTTLKLDWGGETFYANGIQVL 471
K NR D T VY ++ +HF+ S D + R TT KL G ETF ++
Sbjct: 389 -----KLGNRSDFDRDTWRVYEFICRHFMGTVSRDLKYRVTTAKLSVGMETFSCTASVLI 443
Query: 472 ERNFLDIYQWADWKSNDTLPAYQMSDDVVVSKTEMKSGQTSPPKHMTESELIMLMDANGI 531
+ F + W+ + ++ P + V ++ + QT PP ++TESELI LM+ +GI
Sbjct: 444 DAGFTKVMTWSAFGKDEPQPPFVQGTQVAINDVRLIESQTGPPDYLTESELITLMEEHGI 503
Query: 532 GTDATIADHIEKIKSRNYIKVQTGSGSGAKKTASVFLPTSLGRSLVHGFEKIGLEESFSK 591
GTDA+I HI I RNY+ ++ G +PT+LG LVHG++KI +
Sbjct: 504 GTDASIPVHINNICQRNYVHIENG---------RKLMPTTLGIVLVHGYQKI--DPELVL 552
Query: 592 PFLRRDLEKDLQLICGGTKDKKDVVSLIIGMYR---NYYQITTSQMRNLIKVYNDIKAES 648
P +R ++E+ L LI G+ + +DV+ I +++ Y+ M L +V AES
Sbjct: 553 PTMRTEVERMLTLIAQGSANFQDVLRHAIKIFKLKFMYFVKNIDSMDALFEVSFSPLAES 612
>ECU04g1070 [L] KOG1956 DNA topoisomerase III alpha
Length = 621
Score = 325 bits (834), Expect = 1e-88
Identities = 200/541 (36%), Positives = 293/541 (53%), Gaps = 51/541 (9%)
Query: 111 LMIWTDCDREGECIGWEIVQAXXXXXXXXXXXXXXYRAVFSHLEPSHIIASANRPRKLDQ 170
++IWTDCDREGE IG +I RA FS + + ++ ++++
Sbjct: 2 VIIWTDCDREGENIGRQIRDIVLKVKKIDVR-----RARFSGITLRDVESALRNLGEINE 56
Query: 171 RQVDAVRARQEIDLRAGLAFTRLLTGNYRSVLQSDLEYKQLAKKDDKPVISYGTCQFPTL 230
+ +AV R E+DLR G AFTRL T + Q K ++S+G CQ PTL
Sbjct: 57 AEAEAVEVRIELDLRIGSAFTRLQTLSLGRARQG------------KKILSFGPCQVPTL 104
Query: 231 GFVVDRYERVINFIPEQFWHILLSVKDLDGSESKVKFQWERGHLFDRLAVLSIYEHCIGT 290
GFVV+R +F+PE FW + K +F W RG +FDR V+ + G
Sbjct: 105 GFVVERARERESFVPEIFWTLKFKAMH---KGFKDEFTWRRGPVFDRNCVVCFFNSLSG- 160
Query: 291 CEDRAKVIHVSSKDTKKFRPLPLTTVELQKNCSRFFKLSAKKTLDAAEKLYQQGYISYPR 350
+ A+++ K+ K+RPLPL TVELQK CS +F+LS K ++ AE LY +GYISYPR
Sbjct: 161 --EDARIVSREVKEKTKYRPLPLRTVELQKKCSSYFRLSGHKVMEIAEGLYNRGYISYPR 218
Query: 351 TETDKFPAKTDLKSLLNKHQGHSEWGPYVTNLMNENSTSTNKYQWPRSGNHDDQAHPPIH 410
TETD F K D K +L K S+ G Y + LM E + PR+G ++D AH PI+
Sbjct: 219 TETDVFDRKFDFKHILGKLCKDSKVGEYASKLMGE-------FNHPRNGKNNDMAHLPIY 271
Query: 411 PILCVDIAKTDNRMTSDEKTVYNYVVKHFLACCSTDARGRSTTLKLDWGGETFYANGIQV 470
P+ K + ++ ++ +Y++V + FL C + DA+G T +L G E F +GI+V
Sbjct: 272 PL------KEGSGLSGSDRDIYDFVSRRFLGCIAKDAKGLETRYELKIGLEMFDLSGIRV 325
Query: 471 LERNFLDIYQWADWKSNDTLPAYQMSDDVVVSKTEMKSGQTSPPKHMTESELIMLMDANG 530
+ERN+L++Y + W +D +++V E+ G+TS PK+++E+ELI LMD NG
Sbjct: 326 IERNYLEVYYYDKW--DDKEVGDFAVEEIVSGDLEIDEGETSAPKYLSEAELIGLMDKNG 383
Query: 531 IGTDATIADHIEKIKSRNYIKVQTGSGSGAKKTASVFLPTSLGRSLVHGFEKIGLEESFS 590
IGTDATI +HI+KI+ R Y A K A P +LG +L+ G+E+ GL +
Sbjct: 384 IGTDATIHEHIQKIQERGY----------AVKVAEEIRPLNLGTALIEGYERFGL--NVG 431
Query: 591 KPFLRRDLEKDLQLICGGTKDKKDVVSLIIGMYRNYYQITTSQMRNLIKVYN-DIKAESQ 649
KP LR+ LE L+ I G D K VV + YR Y I + + + I+A++
Sbjct: 432 KPELRKSLEVSLKKISDGEIDGKSVVYEGVMAYRGIYAILKRNIGEFASILSRGIEADAS 491
Query: 650 G 650
G
Sbjct: 492 G 492
>Hs4507635 [L] KOG1957 DNA topoisomerase III beta
Length = 862
Score = 319 bits (818), Expect = 7e-87
Identities = 221/648 (34%), Positives = 325/648 (50%), Gaps = 47/648 (7%)
Query: 1 MVKILCVAEKNSIAKNVAQILSGGRSSMRPSTSPYIKNYDFQYDFQWLNMGRCNVTMTAV 60
M +L VAEK S+A+++A+ILS G S + +++ F + MT+V
Sbjct: 1 MKTVLMVAEKPSLAQSIAKILSRGSLSSHKGLNGACSVHEYTGTFAGQPV---RFKMTSV 57
Query: 61 AGHLMNLAFSQNEYGWGKCDPNLLFD-APTID-EMDDKI--VKNLQNEGRHATHLMIWTD 116
GH+M L F W K DP LF APT E + K+ VK LQ EGR ++++W D
Sbjct: 58 CGHVMTLDFLGKYNKWDKVDPAELFSQAPTEKKEANPKLNMVKFLQVEGRGCDYIVLWLD 117
Query: 117 CDREGECIGWEIVQAXX-XXXXXXXXXXXXYRAVFSHLEPSHIIASANRPRKLDQRQVDA 175
CD+EGE I +E++ A +RA FS + + I + + D + +
Sbjct: 118 CDKEGENICFEVLDAVLPVMNKAHGGEKTVFRARFSSITDTDICNAMACLGEPDHNEALS 177
Query: 176 VRARQEIDLRAGLAFTRLLTGNYRSVLQSDLEYKQLAKKDDKPVISYGTCQFPTLGFVVD 235
V ARQE+DLR G AFTR T ++ +Y L D +IS+G CQ PTLGF V+
Sbjct: 178 VDARQELDLRIGCAFTRFQTKYFQG------KYGDL----DSSLISFGPCQTPTLGFCVE 227
Query: 236 RYERVINFIPEQFWHILLSVKDLDGSESKVKFQWERGHLFDRLAVLSIYEHCIGTCEDRA 295
R++++ +F PE +W +L K + + W+R +FDR + E A
Sbjct: 228 RHDKIQSFKPETYW--VLQAKVNTDKDRSLLLDWDRVRVFDREIAQMFLN--MTKLEKEA 283
Query: 296 KVIHVSSKDTKKFRPLPLTTVELQKNCSRFFKLSAKKTLDAAEKLYQQGYISYPRTETDK 355
+V S K+ K RPL L TVE+ + S + + + AE+LY QGYISYPRTET
Sbjct: 284 QVEATSRKEKAKQRPLALNTVEMLRVASSSLGMGPQHAMQTAERLYTQGYISYPRTETTH 343
Query: 356 FPAKTDLKSLLNKHQGHSEWGPYVTNLMNENSTSTNKYQWPRSGNHDDQAHPPIHPILCV 415
+P DLK L + H W V L+ E PR G HD HPPI P+
Sbjct: 344 YPENFDLKGSLRQQANHPYWADTVKRLLAEGINR------PRKG-HDAGDHPPITPMK-- 394
Query: 416 DIAKTDNRMTSDEKTVYNYVVKHFLACCSTDARGRSTTLKLDWGGETFYANGIQVLERNF 475
+ T+ + D +Y Y+ +HF+A S D + +T+ G E F +G VL F
Sbjct: 395 --SATEAELGGDAWRLYEYITRHFIATVSHDCKYLQSTISFRIGPELFTCSGKTVLSPGF 452
Query: 476 LDIYQWADWKSNDTLPAYQMSDDVVVSKTEMKSGQTSPPKHMTESELIMLMDANGIGTDA 535
++ W ++LP Q D V + +M QT+PP ++TE+ELI LM+ +GIGTDA
Sbjct: 453 TEVMPWQSVPLEESLPTCQRGDAFPVGEVKMLEKQTNPPDYLTEAELITLMEKHGIGTDA 512
Query: 536 TIADHIEKIKSRNYIKVQTGSGSGAKKTASVFLPTSLGRSLVHGFEKIGLEESFSKPFLR 595
+I HI I RNY+ V++G PT+LG LVHG+ KI E P +R
Sbjct: 513 SIPVHINNICQRNYVTVESGRR---------LKPTNLGIVLVHGYYKIDAE--LVLPTIR 561
Query: 596 RDLEKDLQLICGGTKDKKDVVSLIIGMYR---NYYQITTSQMRNLIKV 640
+EK L LI G D + V+ + +++ +Y+ + + M L++V
Sbjct: 562 SAVEKQLNLIAQGKADYRQVLGHTLDVFKRKFHYFVDSIAGMDELMEV 609
>CE25309 [L] KOG1957 DNA topoisomerase III beta
Length = 615
Score = 305 bits (780), Expect = 2e-82
Identities = 208/620 (33%), Positives = 308/620 (49%), Gaps = 53/620 (8%)
Query: 4 ILCVAEKNSIAKNVAQILSGGRSSMRPSTSPY--IKNYDFQYDFQWLNMGRCNVTMTAVA 61
+L VAEK +A ++A +LS G++ R + + YD Q+ N +T+
Sbjct: 5 VLMVAEKPLLADSIANLLSNGQAKKRKGWNGVCSVSEYDGQF-----NGRAARFKVTSTC 59
Query: 62 GHLMNLAFSQNEYGWGKCDPNLLFDAPTID-EMDDKIVKN--LQNEGRHATHLMIWTDCD 118
GH+M+L F W + DP L+ APT E + K+ N L +E ++A L++W DCD
Sbjct: 60 GHVMSLDFPPKFNNWERVDPAELYSAPTQRIEANPKMKMNEFLASEAKNADFLVLWLDCD 119
Query: 119 REGECIGWEIVQAX--XXXXXXXXXXXXXYRAVFSHLEPSHIIASANRPRKLDQRQVDAV 176
+EGE I +E++ A YRA FS + I A+ + DQ +V
Sbjct: 120 KEGENICFEVIDAVKCAMFKNRQDFMSDVYRAHFSAITEKDIKAAMRNLGRPDQNMSHSV 179
Query: 177 RARQEIDLRAGLAFTRLLTGNYRSVLQSDLEYKQLAKKDDKPVISYGTCQFPTLGFVVDR 236
ARQE+DLR G +FTR T ++ +Y L D VISYG CQ PTLGF V R
Sbjct: 180 DARQELDLRIGCSFTRFQTKFFQG------KYGDL----DSNVISYGPCQTPTLGFCVTR 229
Query: 237 YERVINFIPEQFWHILLSVKDLDGSESKVKFQWERGHLFDRLAVLSIYEHCIGTCEDRAK 296
+++++ F PEQ+W + + D + +W+RG +FD V ++ I C
Sbjct: 230 HDQIVQFKPEQYWVLKTNFTTSDDGQI-FSPEWQRGRIFDA-EVARVFVDRIKKCHT-GL 286
Query: 297 VIHVSSKDTKKFRPLPLTTVELQKNCSRFFKLSAKKTLDAAEKLYQQGYISYPRTETDKF 356
V+ VS K+ +K RP L TVEL + S +S T+ AE LY QGYISYPRTET +
Sbjct: 287 VLDVSKKEARKERPCALNTVELMRVASSSLGMSPSTTMHVAEALYTQGYISYPRTETTAY 346
Query: 357 PAKTDLKSLLNKHQGHSEWGPYVTNLMNENSTSTNKYQWPRSGNHDDQAHPPIHPILCVD 416
A DL L G +WG V + + P+SG D HPPI P
Sbjct: 347 SANFDLTGTLKILAGDRKWGSVVL---------ADGIKRPKSG-VDKGDHPPITP----- 391
Query: 417 IAKTDNRMTSDEKTVYNYVVKHFLACCSTDARGRSTTLKLDWGGETFYANGIQVLERNFL 476
+ ++ D +Y YV +HF+A TT+K+ G E F G V+E F
Sbjct: 392 MRPNHGGLSGDMSRIYEYVSQHFVATLMKQCVYEVTTVKMSCGDEQFTLQGKNVVEPGFT 451
Query: 477 DIYQWADWKSNDTLP--AYQMSDDVVVSKTEMKSGQTSPPKHMTESELIMLMDANGIGTD 534
+ W + ++P Q+ + + E+++ +T+PP ++TE+ELI LM+ +GIGTD
Sbjct: 452 AVMPWLSVEEECSVPKSLQQIGAKIELQNAEIQARETTPPGYLTEAELITLMEKHGIGTD 511
Query: 535 ATIADHIEKIKSRNYIKVQTGSGSGAKKTASVFLPTSLGRSLVHGFEKIGLEESFSKPFL 594
A+I HI I RNY+ V++G +PT LG+ LV G+ K+ + P +
Sbjct: 512 ASIPVHINTITQRNYVTVESGRR---------LVPTRLGQCLVRGYWKV--DPELVLPTM 560
Query: 595 RRDLEKDLQLICGGTKDKKD 614
R +LE+ L L+ G D D
Sbjct: 561 RAELEEQLNLVASGKADYLD 580
>At2g32000 [L] KOG1957 DNA topoisomerase III beta
Length = 836
Score = 246 bits (627), Expect = 1e-64
Identities = 194/643 (30%), Positives = 298/643 (46%), Gaps = 126/643 (19%)
Query: 7 VAEKNSIAKNVAQILSGGRSSMRPSTSPYIKNYDFQYDFQWLNMG-RCNVTMTAVAGHLM 65
VAEK SIA ++A +LS G+ S R ++ ++F + G + + +T+V GH+
Sbjct: 40 VAEKPSIALSIASVLSHGQMSTRRGSTEV-------HEFDGMFRGFKAHYRVTSVIGHVF 92
Query: 66 NLAFSQNEYGWGKCDPNLLFDAPTIDEMDDK----------IVKNLQNEGRHATHLMIWT 115
++ F + W DP LFDAP I + + I ++L NE R +++++W
Sbjct: 93 SVDFPEKYQNWATIDPQDLFDAPIIKKESNPKVNIFKSQAHICRHLSNEARGCSYMVLWL 152
Query: 116 DCDREGECIGWEIVQAXXXXXXXXXXXXXXYRAVFSHLEPSHIIASANRPRKLDQRQVDA 175
DCDREGE I +E++++ YRA FS + I + + + ++ + A
Sbjct: 153 DCDREGENICFEVIESTGFDMKDSKRKV--YRARFSSVTEKDISKAMDNLVEPNRDEALA 210
Query: 176 VRARQEIDLRAGLAFTRLLTGNYRSVLQSDLEYKQLAKKDDKPVISYGTCQFPTLGFVVD 235
V ARQEIDL+ LL +R YG CQ PTLGF V
Sbjct: 211 VDARQEIDLKI------LLNVYFR----------------------YGPCQTPTLGFCVQ 242
Query: 236 RYERVINFIPEQFWHILLSVKDLDGSESKVKFQWERGHLFDRLAVLSIYEHCIGTCEDR- 294
RY + F PE+FW + ++ DG E ++ +WER LFD L ++++ + E R
Sbjct: 243 RYMHINTFKPEKFWALRPYIRK-DGYE--LQLEWERRRLFD-LEAATVFQKLV--VEGRT 296
Query: 295 AKVIHVSSKDTKKFRPLPLTTVELQKNCSRFFKLSAKKTLDAAEKLYQQGYISYPRTETD 354
AKV+ VS K K RP L TV L K CSR + GY S
Sbjct: 297 AKVMDVSEKQEVKGRPAGLNTVNLLK-CSRVWA--------------SDGYASCRAIVYS 341
Query: 355 KFPAKTDLKSLLNKHQGHSEWGPYVTNLMNENSTSTNKYQWPRSGNHDDQAHPPIHPILC 414
+F HQ ++ G HPPI P+
Sbjct: 342 RF------------HQSGTDAGD----------------------------HPPITPMR- 360
Query: 415 VDIAKTDNRMTSDEKTVYNYVVKHFLACCSTDARGRSTTLKLDWGGETFYANGIQVLERN 474
A T+ + D +Y YV +HFL S + + T ++L GGETF+ G +V E+
Sbjct: 361 ---AATEVMVGGDAWRLYQYVCQHFLGTVSPNCKYIRTKVELSIGGETFHCTGQRVTEKG 417
Query: 475 FLDIYQWADWKSNDTLPAYQMSDDVVVSKTEMKSGQTSPPKHMTESELIMLMDANGIGTD 534
F I W+ LP++ + + V + E+ G T+PP ++TESELI LM+ +GIGTD
Sbjct: 418 FTAIMPWSA-VDEKKLPSFLKGERIEVLRVELYEGNTAPPDYLTESELISLMEKHGIGTD 476
Query: 535 ATIADHIEKIKSRNYIKVQTGSGSGAKKTASVFLPTSLGRSLVHGFEKIGLEESFSKPFL 594
A+IA HI I RNY++VQ+G +PT+LG +L+ G++ I + P +
Sbjct: 477 ASIAVHINNIGERNYVQVQSG---------RKMVPTALGITLIRGYQCI--DPDLCLPDI 525
Query: 595 RRDLEKDLQLICGGTKDKKDVVSLIIGMYRNYYQITTSQMRNL 637
R +E+ + L+ G D VV +I +R + Q+ ++
Sbjct: 526 RSFIEQQITLVAKGQADHSHVVQHVIQQFRRKFSYFVQQIEHM 568
>At4g31210_2 [L] KOG1956 DNA topoisomerase III alpha
Length = 676
Score = 83.2 bits (204), Expect = 1e-15
Identities = 124/559 (22%), Positives = 212/559 (37%), Gaps = 109/559 (19%)
Query: 100 NLQNEGRHATHLMIWTDCDREGECIGWEIVQAXXXXXXXXXXXXXXYRAVFSHLEPSHII 159
++++ A +L++ +D DREGE I W I++ R VF + S I
Sbjct: 1 HIRDLATRAENLILASDPDREGEAIAWHIIEMLQQQGALHESMTVA-RVVFHEITESAIK 59
Query: 160 ASANRPRKLDQRQVDAVRARQEIDLRAGLAFTRLLTGNYRSVLQSDLEYKQLAKKDDKPV 219
++ PR++D V A AR+ +D G + LL K P
Sbjct: 60 SALQSPREIDGDLVHAYLARRALDYLIGFNISPLLW----------------RKLPGCP- 102
Query: 220 ISYGTCQFPTLGFVVDRYERVINFIPEQFWHILLSVKDLDGSESKVKFQWERGHLFD--- 276
S G Q L V DR + F P+++W + + VK D S + HL
Sbjct: 103 -SAGRVQSAALALVCDRESEIDGFKPQEYWTVGIKVKGKDNSATF------SAHLTSLNS 155
Query: 277 -RLAVLSIYEHCIGT-CEDRAK-----VIHVSSKDTKKFRPLPLTTVELQKNCSRFFKLS 329
RL LSI E R K V + T+K P P T LQ++ + S
Sbjct: 156 KRLNQLSISSEANAQDIEQRIKSEGFLVKGTKTSTTRKNPPTPYITSTLQQDAANKLHFS 215
Query: 330 AKKTLDAAEKLYQQGYISYPRTETDKFPAKTDLKSLLNKHQGHSEWGPYVTNLMNENSTS 389
T+ A++ A D++SL+ + G +N TS
Sbjct: 216 TAHTMKIADE------------------AIKDIQSLVAERYG-------------KNFTS 244
Query: 390 TNKYQWPRSGNHDDQAHPPIHPILCVDIAKTDNRMTS----DEKTVYNYVVKHFLACCST 445
+ ++ + + +AH I P DI + + + S D +Y + +AC
Sbjct: 245 DSPRKYFKKVKNAQEAHEAIRP---TDIRRLPSTIASLLDADSLKLYTLIWSRAVACQME 301
Query: 446 DARGRSTTLKLDWGGET--FYANGIQVLERNFLDIYQWADWKS-----ND---------- 488
A L + E+ F ++ +V + +Y+ + K+ ND
Sbjct: 302 PASIAQIQLDIGNASESIIFRSSCSKVEFLGYQAVYEDPEAKAIKNNDNDQSSEREETFK 361
Query: 489 TLPAYQMSDDVVVSKTEMKSGQTSPPKHMTESELIMLMDANGIGTDATIADHIEKIKSRN 548
TL + + D + + + E+K T P +E L+ ++ GIG +T A ++ R
Sbjct: 362 TLSSLKDGDLLQIGEVELKQHHTQHPPRYSEGSLVKKLEELGIGRPSTYASIFRVLQHRK 421
Query: 549 YIKVQTGSGSGAKKTASVFLPTSLGRSLVHGFEKIGLEESFSKPFLRRDLEKDLQLICGG 608
Y+ ++ + F + L H F +I + SF+ D+E +L + GG
Sbjct: 422 YVTIKN------RVLYPEFRARMVSAFLTHYFTEI-TDYSFT-----ADMETELDNVSGG 469
Query: 609 TKDKKDVVSLIIGMYRNYY 627
+ K G+ R+Y+
Sbjct: 470 VTEWK-------GLLRDYW 481
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.318 0.134 0.403
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 38,767,417
Number of Sequences: 60738
Number of extensions: 1640465
Number of successful extensions: 3907
Number of sequences better than 1.0e-05: 11
Number of HSP's better than 0.0 without gapping: 10
Number of HSP's successfully gapped in prelim test: 1
Number of HSP's that attempted gapping in prelim test: 3807
Number of HSP's gapped (non-prelim): 13
length of query: 659
length of database: 30,389,216
effective HSP length: 113
effective length of query: 546
effective length of database: 23,525,822
effective search space: 12845098812
effective search space used: 12845098812
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)