ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactVI5570 good P KOG1484 Inorganic ion transport and metabolism Putative Zn2+ transporter MSC2 (cation diffusion facilitator superfamily)
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactVI5570 1936200 1934092 -703
(703 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YDR205w [P] KOG1484 Putative Zn2+ transporter MSC2 (cation diffu... 395 e-110
At2g04620 [P] KOG1484 Putative Zn2+ transporter MSC2 (cation dif... 145 2e-34
Hs20070323_2 [P] KOG1484 Putative Zn2+ transporter MSC2 (cation ... 145 2e-34
7299414 [P] KOG1484 Putative Zn2+ transporter MSC2 (cation diffu... 134 4e-31
CE26955_2 [P] KOG1484 Putative Zn2+ transporter MSC2 (cation dif... 131 3e-30
SPAC17D4.03c [P] KOG1484 Putative Zn2+ transporter MSC2 (cation ... 117 5e-26
Hs19424134 [P] KOG1484 Putative Zn2+ transporter MSC2 (cation di... 111 3e-24
7292347 [P] KOG1483 Zn2+ transporter ZNT1 and related Cd2+/Zn2+ ... 74 6e-13
Hs22041687 [P] KOG1484 Putative Zn2+ transporter MSC2 (cation di... 74 8e-13
CE16617 [P] KOG1482 Zn2+ transporter 73 1e-12
CE16616 [P] KOG1482 Zn2+ transporter 73 1e-12
YMR243c [P] KOG1483 Zn2+ transporter ZNT1 and related Cd2+/Zn2+ ... 70 1e-11
ECU11g1510 [P] KOG1482 Zn2+ transporter 65 3e-10
YOR316c [P] KOG1483 Zn2+ transporter ZNT1 and related Cd2+/Zn2+ ... 65 4e-10
SPAC23C11.14 [P] KOG1483 Zn2+ transporter ZNT1 and related Cd2+/... 64 6e-10
Hs20540985 [P] KOG1482 Zn2+ transporter 62 3e-09
Hs14141726 [P] KOG1483 Zn2+ transporter ZNT1 and related Cd2+/Zn... 60 1e-08
CE03664 [P] KOG1482 Zn2+ transporter 59 2e-08
Hs22041360 [P] KOG1483 Zn2+ transporter ZNT1 and related Cd2+/Zn... 58 4e-08
CE29581 [P] KOG1483 Zn2+ transporter ZNT1 and related Cd2+/Zn2+ ... 57 1e-07
CE27065 [P] KOG1483 Zn2+ transporter ZNT1 and related Cd2+/Zn2+ ... 57 1e-07
HsM7019533 [P] KOG1482 Zn2+ transporter 52 4e-06
Hs21359890 [P] KOG1482 Zn2+ transporter 52 4e-06
>YDR205w [P] KOG1484 Putative Zn2+ transporter MSC2 (cation diffusion
facilitator superfamily)
Length = 740
Score = 395 bits (1016), Expect = e-110
Identities = 230/538 (42%), Positives = 295/538 (54%), Gaps = 71/538 (13%)
Query: 177 LLSVSCISLVIMYLWVTLSTDNQTKITKINYSMLFVFLGCTLVLLLVCQDIKTTLDNQP- 235
+L + S V++YL ++ K I M+FVF GC + L +D+ T NQ
Sbjct: 239 ILVLPIFSFVLLYLMTIVN-----KTYNIQLLMVFVFFGCLSIFFLSLKDLFTEDGNQKK 293
Query: 236 ----------------FATVWQNQYSATIIGFMAMVLQYLSFNAISSSSKSDFLTAVFIL 279
+ +W +++ + G MA+V+ +LSFN I+SS K+D L+ +F++
Sbjct: 294 GGQEDEYCRMFDIKYMISYLWLTRFTILLTGIMAIVVHFLSFNEITSSIKTDLLSLLFVV 353
Query: 280 ISGILPSSLEYENQGYHPKEDENPDKHCQHQLNXXXXXXXXXXXXXXXXXDSKELLENEK 339
++ EY + + + D + H H + LENE
Sbjct: 354 VA-------EYVSSFSNKQPDSHSHNHAHHHSHLTDSLP----------------LENES 390
Query: 340 EFLTTSKLLMSLATNKETKSIFSFLLLNSAFMFVQXXXXXXXXXXXXXXXXXHMALDCTS 399
F +A NK+T+SIFSFLLLN+AFMFVQ HMALDCTS
Sbjct: 391 MF-------KQMALNKDTRSIFSFLLLNTAFMFVQLLYSFRSKSLGLLSDSLHMALDCTS 443
Query: 400 LFLGLLAGVLSKYPASDKYPFALGYLETIAGFTNGVLLIGIVIEIFIESFQRIFNPVTIL 459
L LGL+AGVL+K PASDK+PF L YL T+AGFTNGVLL+GIV IF+E+ +RIFNP+ +
Sbjct: 444 LLLGLIAGVLTKKPASDKFPFGLNYLGTLAGFTNGVLLLGIVCGIFVEAIERIFNPIHLH 503
Query: 460 GTTELLVVSILGLLVNVVGLCAFDHG-HAHGEHESNDNMRGIFLHVLADTLGSVGVIIST 518
T ELLVV+ LGLLVN+VGL AFDHG H HG + N+NM+GIFLH+LADTLGSVGV+IST
Sbjct: 504 ATNELLVVATLGLLVNLVGLFAFDHGAHDHGGTD-NENMKGIFLHILADTLGSVGVVIST 562
Query: 519 LLTKIFKSQIFDPIASFFIAXXXXXXXXXXXXXXXXXXXXKVDDKKHALLKNVLNQIVST 578
LL K+ IFDPIAS I ++DDKKH L+K+ LNQI +T
Sbjct: 563 LLIKLTHWPIFDPIASLLIGSLILLSALPLLKSTSANILLRLDDKKHNLVKSALNQISTT 622
Query: 579 PGVTGYTAPRFWPXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXPVEXXXXX 638
PG+TGYT PRFWP
Sbjct: 623 PGITGYTTPRFWPTESGSSGHSHAHTHSHAENHSHEH-----------------HHDQKN 665
Query: 639 XXXXXXXLVGYIHVQYIDGENSTIIKKRVERIFERANIKVWIQVEAQSSACWCRATSM 696
LVGYIHVQY+DGENSTIIKKRVE+IFE +IK W+QVE Q+S CWCRATSM
Sbjct: 666 GSQEHPSLVGYIHVQYVDGENSTIIKKRVEKIFENVSIKAWVQVEPQNSTCWCRATSM 723
>At2g04620 [P] KOG1484 Putative Zn2+ transporter MSC2 (cation diffusion
facilitator superfamily)
Length = 300
Score = 145 bits (367), Expect = 2e-34
Identities = 92/259 (35%), Positives = 131/259 (50%), Gaps = 11/259 (4%)
Query: 335 LENEKEFLTT-SKLLMSLATNKETKSIFSFLLLNSAFMFVQXXXXXXXXXXXXXXXXXHM 393
+E+ + F T K + + + K+++ I FLL+N+A+M V+ HM
Sbjct: 1 MESPESFSTMFMKPIRHILSEKKSRKIALFLLINTAYMVVEFVAGFMSNSLGLISDACHM 60
Query: 394 ALDCTSLFLGLLAGVLSKYPASDKYPFALGYLETIAGFTNGVLLIGIVIEIFIESFQRIF 453
DC +L +GL A +S+ PA+ +Y + G E ++G+ N V L+ + I +ES +RI
Sbjct: 61 LFDCAALAIGLYASYISRLPANHQYNYGRGRFEVLSGYVNAVFLVLVGALIVLESIERIL 120
Query: 454 NPVTILGTTELLVVSILGLLVNVVGLCAF--DHGHAHGEHESNDNMRGIFLHVLADTLGS 511
+P I T LLVVS+ GLLVN+VGL F +H HAHG GIFLHVLADT+GS
Sbjct: 121 DPQEI-STNSLLVVSVGGLLVNIVGLIFFHEEHHHAHGG-------SGIFLHVLADTMGS 172
Query: 512 VGVIISTLLTKIFKSQIFDPIASFFIAXXXXXXXXXXXXXXXXXXXXKVDDKKHALLKNV 571
VGV+ISTLL K + DP +S FI+ +V LK
Sbjct: 173 VGVVISTLLIKYKGWLVADPASSIFISILIIASVIPLLRNSAEILLQRVPRAHRQDLKEA 232
Query: 572 LNQIVSTPGVTGYTAPRFW 590
+ I+ T GV W
Sbjct: 233 MRNILKTKGVCSIQRLHVW 251
>Hs20070323_2 [P] KOG1484 Putative Zn2+ transporter MSC2 (cation diffusion
facilitator superfamily)
Length = 674
Score = 145 bits (366), Expect = 2e-34
Identities = 89/277 (32%), Positives = 129/277 (46%), Gaps = 35/277 (12%)
Query: 348 LMSLATNKETKSIFSFLLLNSAFMFVQXXXXXXXXXXXXXXXXXHMALDCTSLFLGLLAG 407
L + +++ IF FL LN F FV+ HM DC++L +GL A
Sbjct: 316 LKQILEESDSRQIFYFLCLNLLFTFVELFYGVLTNSLGLISDGFHMLFDCSALVMGLFAA 375
Query: 408 VLSKYPASDKYPFALGYLETIAGFTNGVLLIGIVIEIFIESFQRIFNPVTILGTTELLVV 467
++S++ A+ + + G +E ++GF NG+ LI I +F+ES R+ +P L T L V
Sbjct: 376 LMSRWKATRIFSYGYGRIEILSGFINGLFLIVIAFFVFMESVARLIDPPE-LDTHMLTPV 434
Query: 468 SILGLLVNVVGLCAFDHGHAHGEHES---------------------------------- 493
S+ GL+VN++G+CAF H H+H S
Sbjct: 435 SVGGLIVNLIGICAFSHAHSHAHGASQGSCHSSDHSHSHHMHGHSDHGHGHSHGSAGGGM 494
Query: 494 NDNMRGIFLHVLADTLGSVGVIISTLLTKIFKSQIFDPIASFFIAXXXXXXXXXXXXXXX 553
N NMRG+FLHVLADTLGS+GVI+ST+L + F I DP+ S FIA
Sbjct: 495 NANMRGVFLHVLADTLGSIGVIVSTVLIEQFGWFIADPLCSLFIAILIFLSVVPLIKDAC 554
Query: 554 XXXXXKVDDKKHALLKNVLNQIVSTPGVTGYTAPRFW 590
++ + L L +I G+ Y P FW
Sbjct: 555 QVLLLRLPPEYEKELHIALEKIQKIEGLISYRDPHFW 591
>7299414 [P] KOG1484 Putative Zn2+ transporter MSC2 (cation diffusion
facilitator superfamily)
Length = 366
Score = 134 bits (338), Expect = 4e-31
Identities = 91/292 (31%), Positives = 126/292 (42%), Gaps = 55/292 (18%)
Query: 353 TNKETKSIFSFLLLNSAFMFVQXXXXXXXXXXXXXXXXXHMALDCTSLFLGLLAGVLSKY 412
+++ ++++F FLLLN +F FV+ HM DCT L GL A V++K+
Sbjct: 29 SDRNSRNLFLFLLLNLSFAFVELFYGIVTNSLGLISDSFHMFFDCTGLLAGLAASVITKW 88
Query: 413 PASDKYPFALGYLETIAGFTNGVLLIGIVIEIFIESFQRIFNPVTILGTTELLVVSILGL 472
A+DK+ + E +AGF N + L+ I I E +R+ P + L VVS+LGL
Sbjct: 89 KANDKFSYGYVRAEVLAGFVNSLFLLFIAFFILSEGVERLIEPPEVKHE-RLFVVSVLGL 147
Query: 473 LVNVVGLCAFD---HGHAHGEH----------------------------------ESND 495
LVN+VG+ AF+ HGH+HG H S+D
Sbjct: 148 LVNLVGIYAFNHGGHGHSHGGHGHSHGGGHGHGHSHGHTDAGNHNHQAITLDNGHGHSHD 207
Query: 496 N-----------------MRGIFLHVLADTLGSVGVIISTLLTKIFKSQIFDPIASFFIA 538
+ MRG+FLH+LADTLGSVGVIIS +L +F I DPI S FIA
Sbjct: 208 HDSHGHSHGDMSGSNSQIMRGVFLHILADTLGSVGVIISAVLMHMFGWMIADPICSIFIA 267
Query: 539 XXXXXXXXXXXXXXXXXXXXKVDDKKHALLKNVLNQIVSTPGVTGYTAPRFW 590
+ L ++ GV P FW
Sbjct: 268 LLIALSVLSLIKESIMILMQRQPADLDRSLPQCYQKVTGLAGVYAVQEPHFW 319
>CE26955_2 [P] KOG1484 Putative Zn2+ transporter MSC2 (cation diffusion
facilitator superfamily)
Length = 758
Score = 131 bits (330), Expect = 3e-30
Identities = 84/228 (36%), Positives = 125/228 (53%), Gaps = 27/228 (11%)
Query: 331 SKELLENEKEFLTTSKLLMSLATNKETKSIFSFLLLNSAFMFVQXXXXXXXXXXXXXXXX 390
SK L+ KE T +++LM N +++ IF FL +N F V+
Sbjct: 303 SKSLMLFMKE--TLNEILM----NNDSRRIFWFLCVNLGFCGVEFLYGFWTNSLGLISDG 356
Query: 391 XHMALDCTSLFLGLLAGVLSKYPASDKYPFALGYLETIAGFTNGVLLIGIVIEIFIESFQ 450
HM DC++L +GL+A V++++P + + F G +E ++GF N + L I + I IE+ +
Sbjct: 357 FHMLFDCSALVMGLVASVMARWPPTRHFTFGFGRVEILSGFINALFLCVIALFILIEALE 416
Query: 451 RIFNPVTILGTTELLVVSILGLLVNVVGLCAF-DHGHAHGEHES---------------- 493
R+F+P I T LL V+I GL+VN+ G+ + +HGH+HG S
Sbjct: 417 RLFDPPNI-NTDRLLFVAISGLIVNLFGMYSLGEHGHSHGGGSSHGHSHGGGGSHGHSHG 475
Query: 494 ---NDNMRGIFLHVLADTLGSVGVIISTLLTKIFKSQIFDPIASFFIA 538
N NM+G+FLHVLADTLGSV VIISTLL + F DP+ S ++
Sbjct: 476 GGGNANMQGVFLHVLADTLGSVFVIISTLLIQWFGWVWVDPLCSLILS 523
>SPAC17D4.03c [P] KOG1484 Putative Zn2+ transporter MSC2 (cation diffusion
facilitator superfamily)
Length = 732
Score = 117 bits (294), Expect = 5e-26
Identities = 61/154 (39%), Positives = 91/154 (58%), Gaps = 5/154 (3%)
Query: 347 LLMSLATNKETKSIFSFLLLNSAFMFVQXXXXXXXXXXXXXXXXXHMALDCTSLFLGLLA 406
++ + +KE++SIF F LLN ++MFVQ HMA DC ++ +GL+A
Sbjct: 337 IVNGVLADKESRSIFYFFLLNVSYMFVQVIYGLWTNSLGLISDAIHMAFDCIAILVGLVA 396
Query: 407 GVLSKYPASDKYPFALGYLETIAGFTNGVLLIGIVIEIFIESFQRIFNPVTILGTTELLV 466
L+K P + YPF +E ++GFTNG+ L+ I I E+ R+F+P + T +LL+
Sbjct: 397 TTLAKMPLNYAYPFGFAKIEALSGFTNGIFLVLISFSIVGEALYRLFHPPQ-MNTDQLLL 455
Query: 467 VSILGLLVNVVGLCAFDHGHAHG----EHESNDN 496
VS LGL+VN+VG+ AF+HGH H H S+ N
Sbjct: 456 VSFLGLVVNLVGILAFNHGHNHDHGSHHHHSHSN 489
Score = 77.8 bits (190), Expect = 5e-14
Identities = 44/108 (40%), Positives = 56/108 (51%), Gaps = 2/108 (1%)
Query: 483 DHGHAHGEHESNDNMRGIFLHVLADTLGSVGVIISTLLTKIFKSQIFDPIASFFIAXXXX 542
DH H H HE N NM GIFLH++ADT+GSVGVI+ST+L + F FDP+AS IA
Sbjct: 571 DH-HCHHHHE-NHNMHGIFLHIIADTMGSVGVIVSTILIQWFSWTGFDPLASLIIAALIF 628
Query: 543 XXXXXXXXXXXXXXXXKVDDKKHALLKNVLNQIVSTPGVTGYTAPRFW 590
D + LLK L+ I + V + P+FW
Sbjct: 629 VSVLPLIKDSAKNLLSVTDPESEYLLKQCLSNISLSNSVISLSNPKFW 676
>Hs19424134 [P] KOG1484 Putative Zn2+ transporter MSC2 (cation diffusion
facilitator superfamily)
Length = 376
Score = 111 bits (278), Expect = 3e-24
Identities = 75/249 (30%), Positives = 109/249 (43%), Gaps = 61/249 (24%)
Query: 350 SLATNKETKSIFSFLLLNSAFMFVQXXXXXXXXXXXXXXXXXHMALDCTSLFLGLLAGVL 409
S+ ++K ++++F FL LN +F FV+ HM D T++ GL A V+
Sbjct: 28 SILSDKTSRNLFFFLCLNLSFAFVELLYGIWSNCLGLISDSFHMFFDSTAILAGLAASVI 87
Query: 410 SKYPASDKYPFALGYLETIAGFTNGVLLIGIVIEIFIESFQRIFNPVTILGTTELLVVSI 469
SK+ +D + + E +AGF NG+ LI IF E +R P + LL+VSI
Sbjct: 88 SKWGDNDAFSYGYVRAEVLAGFVNGLFLIFTAFFIFSEGVERALAPPDV-HHERLLLVSI 146
Query: 470 LGLLVNVVGLCAF----------------------------------------------- 482
LG +VN++G+ F
Sbjct: 147 LGFVVNLIGIFVFKHGGHGHSHGSGHGHSHSLFNGALDQAHGHVDHCHSHEVKHGAAHSH 206
Query: 483 DHGHAHGEHESNDN-------------MRGIFLHVLADTLGSVGVIISTLLTKIFKSQIF 529
DH H HG S+D ++G+FLH+LADTLGS+GVI S ++ + F I
Sbjct: 207 DHAHGHGHFHSHDGPSLKETTGPSRQILQGVFLHILADTLGSIGVIASAIMMQNFGLMIA 266
Query: 530 DPIASFFIA 538
DPI S IA
Sbjct: 267 DPICSILIA 275
>7292347 [P] KOG1483 Zn2+ transporter ZNT1 and related Cd2+/Zn2+
transporters (cation diffusion facilitator superfamily)
Length = 449
Score = 74.3 bits (181), Expect = 6e-13
Identities = 60/211 (28%), Positives = 82/211 (38%), Gaps = 51/211 (24%)
Query: 360 IFSFLLLNSAFMFVQXXXXXXXXXXXXXXXXXHMALDCTSLFLGLLAGVLSKYPASDKYP 419
+ S + L + F FV+ HM D +L + L+ +S S K
Sbjct: 11 LLSMMWLTAFFFFVEIIVGYVTNSMALVADSFHMLGDIAALVISFLSVKMSPKKWS-KNT 69
Query: 420 FALGYLETIAGFTNGVLLIGIVIEIFIESFQRIFNPVTILGTTELLVVSILGLLVNVVGL 479
F E + N V L+ + I IE+ +R I L++V LGLLVNV+GL
Sbjct: 70 FGWARAEVLGALVNAVFLVALCFSITIEACKRFIEEEPIHEPELLVIVGALGLLVNVIGL 129
Query: 480 CAF-----DHGHAH-------------------GEHESND-------------------- 495
C HGH+H GE E ND
Sbjct: 130 CLLYEHGGHHGHSHGGGLTRNHSRLTELANMDEGEDEQNDFAYEKQKEKAPVKKSSHGHS 189
Query: 496 ------NMRGIFLHVLADTLGSVGVIISTLL 520
NMRG FLHVL+D LGS+ V+IS ++
Sbjct: 190 HDPGQMNMRGAFLHVLSDALGSIIVVISAVV 220
>Hs22041687 [P] KOG1484 Putative Zn2+ transporter MSC2 (cation diffusion
facilitator superfamily)
Length = 230
Score = 73.9 bits (180), Expect = 8e-13
Identities = 43/122 (35%), Positives = 62/122 (50%), Gaps = 2/122 (1%)
Query: 392 HMALDCTSLFLGLLAGVLSKYPASDKYPFALGYLETIAGFTNGVLLIGIVIEIFIESFQR 451
HM D T++ GL A V+SK+ +D + + E +AGF NG+ LI IF E +R
Sbjct: 53 HMFFDSTAILAGLAASVISKWRDNDAFSYGYVRAEVLAGFVNGLFLIFTAFFIFSEGVER 112
Query: 452 IFNPVTILGTTELLVVSILGLLVNVVGLCAFDH-GHAHGEHESNDNMRGIFLHVLADTLG 510
P + LL+VSILG +VN++G+ F H GH H + + +F L G
Sbjct: 113 ALAPPDV-HHERLLLVSILGFVVNLIGIFVFKHGGHGHSHGSGHGHSHSLFNGALDQAHG 171
Query: 511 SV 512
V
Sbjct: 172 HV 173
>CE16617 [P] KOG1482 Zn2+ transporter
Length = 410
Score = 73.2 bits (178), Expect = 1e-12
Identities = 48/194 (24%), Positives = 87/194 (44%), Gaps = 13/194 (6%)
Query: 358 KSIFSFLLLNSAFMFVQXXXXXXXXXXXXXXXXXHMALDCTSLFLGLLAGVLSKYPASDK 417
K +++ L++ F+ + HM D S + + A ++ PAS +
Sbjct: 103 KVLWAVAALSAVFIAAEFVGGFWAQSLAIMTDAGHMLSDLLSFIISIFAIRCARLPASKR 162
Query: 418 YPFALGYLETIAGFTNGVLLIGIVIEIFIESFQRIFNPVTILGTTELLVVSILGLLVNVV 477
F E + T+ ++L + + + + QRI N + +L+ + +G+L N+V
Sbjct: 163 LSFGYERAEVLGALTSVIILWVLTTVLVVVAIQRIVNNEHEVDADVMLITAGVGVLFNIV 222
Query: 478 -GLCAF----DHGHAHGEHES--------NDNMRGIFLHVLADTLGSVGVIISTLLTKIF 524
GL HGH HG H S N N+R +HV+ D + S+GV+I+ L+ +
Sbjct: 223 MGLVLHFGTGGHGHTHGGHSSHGHAHDGKNVNVRAALIHVIGDLVQSIGVLIAALIIRFT 282
Query: 525 KSQIFDPIASFFIA 538
+ DPI +F +
Sbjct: 283 GWTLADPICTFLFS 296
>CE16616 [P] KOG1482 Zn2+ transporter
Length = 391
Score = 73.2 bits (178), Expect = 1e-12
Identities = 48/194 (24%), Positives = 87/194 (44%), Gaps = 13/194 (6%)
Query: 358 KSIFSFLLLNSAFMFVQXXXXXXXXXXXXXXXXXHMALDCTSLFLGLLAGVLSKYPASDK 417
K +++ L++ F+ + HM D S + + A ++ PAS +
Sbjct: 84 KVLWAVAALSAVFIAAEFVGGFWAQSLAIMTDAGHMLSDLLSFIISIFAIRCARLPASKR 143
Query: 418 YPFALGYLETIAGFTNGVLLIGIVIEIFIESFQRIFNPVTILGTTELLVVSILGLLVNVV 477
F E + T+ ++L + + + + QRI N + +L+ + +G+L N+V
Sbjct: 144 LSFGYERAEVLGALTSVIILWVLTTVLVVVAIQRIVNNEHEVDADVMLITAGVGVLFNIV 203
Query: 478 -GLCAF----DHGHAHGEHES--------NDNMRGIFLHVLADTLGSVGVIISTLLTKIF 524
GL HGH HG H S N N+R +HV+ D + S+GV+I+ L+ +
Sbjct: 204 MGLVLHFGTGGHGHTHGGHSSHGHAHDGKNVNVRAALIHVIGDLVQSIGVLIAALIIRFT 263
Query: 525 KSQIFDPIASFFIA 538
+ DPI +F +
Sbjct: 264 GWTLADPICTFLFS 277
>YMR243c [P] KOG1483 Zn2+ transporter ZNT1 and related Cd2+/Zn2+
transporters (cation diffusion facilitator superfamily)
Length = 442
Score = 70.1 bits (170), Expect = 1e-11
Identities = 50/154 (32%), Positives = 69/154 (44%), Gaps = 9/154 (5%)
Query: 351 LATNKETKSIFSFLLLNSAFMFVQXXXXXXXXXXXXXXXXXHMALDCTSLFLGLLAGVLS 410
+ T KE + I S L L++ F ++ HM D SL + L A ++
Sbjct: 1 MITGKELR-IISLLTLDTVFFLLEITIGYMSHSLALIADSFHMLNDIISLLVALWAVDVA 59
Query: 411 KYPASD-KYPFALGYLETIAGFTNGVLLIGIVIEIFIESFQRIFNPVTILGTTELLVVSI 469
K D KY + E + N V LI + I IE+ QR+ P I +L V +
Sbjct: 60 KNRGPDAKYTYGWKRAEILGALINAVFLIALCFSIMIEALQRLIEPQEIQNPRLVLYVGV 119
Query: 470 LGLLVNVVGLCAF-DHG------HAHGEHESNDN 496
GL+ NVVGL F DHG H+HG ES +N
Sbjct: 120 AGLISNVVGLFLFHDHGSDSLHSHSHGSVESGNN 153
>ECU11g1510 [P] KOG1482 Zn2+ transporter
Length = 334
Score = 65.5 bits (158), Expect = 3e-10
Identities = 46/192 (23%), Positives = 89/192 (45%), Gaps = 3/192 (1%)
Query: 349 MSLATNKETKSIFSFLLLNSAFMFVQXXXXXXXXXXXXXXXXXHMALDCTSLFLGLLAGV 408
++ + + + + I LL+ FMF++ H+ +D + LL+
Sbjct: 13 VTCSNDADIRKISKVLLIILMFMFLELWGHWKTNSLSLLADSLHLLVDIFGFIVSLLSLS 72
Query: 409 LSKYPASDKYPFALGYLETIAGFTNGVLLIGIVIEIFIESFQRIFNPVTILGTTELLVVS 468
+K P++ + F +E I + L+ V + IESF + +P I G ++
Sbjct: 73 WAKKPSNKRMTFGYHRIEIIGSMVSIGLIWAAVGYLVIESFHKYLHPAEIDGGM-FFGIA 131
Query: 469 ILGLLVNVVGLCAFDHG-HAHGEHESNDNMRGIFLHVLADTLGSVGVIISTLLTKIFKSQ 527
++G VN + + + + H N N+R ++HV+ D + SVGVII+ ++T + S+
Sbjct: 132 VVGFFVNCICIYVLHYDEYQHKLKHKNLNIRATYVHVVGDLIQSVGVIIAGMVTYFYPSK 191
Query: 528 -IFDPIASFFIA 538
I D I + F +
Sbjct: 192 AIVDVICTMFFS 203
>YOR316c [P] KOG1483 Zn2+ transporter ZNT1 and related Cd2+/Zn2+
transporters (cation diffusion facilitator superfamily)
Length = 439
Score = 65.1 bits (157), Expect = 4e-10
Identities = 45/142 (31%), Positives = 63/142 (43%), Gaps = 7/142 (4%)
Query: 354 NKETKSIFSFLLLNSAFMFVQXXXXXXXXXXXXXXXXXHMALDCTSLFLGLLAGVLSKYP 413
+K+ K I S LLL++ F ++ HM D SL + L A ++K
Sbjct: 5 SKQVK-IISLLLLDTVFFGIEITTGYLSHSLALIADSFHMLNDIISLVVALWAVNVAKNR 63
Query: 414 ASDK-YPFALGYLETIAGFTNGVLLIGIVIEIFIESFQRIFNPVTILGTTELLVVSILGL 472
D Y + E + N V LI + + I IE+ QRI P I +L V + GL
Sbjct: 64 NPDSTYTYGWKRAEILGALINAVFLIALCVSILIEALQRIIAPPVIENPKFVLYVGVAGL 123
Query: 473 LVNVVGLCAF-----DHGHAHG 489
+ N VGL F +HGH HG
Sbjct: 124 ISNTVGLFLFHDNDQEHGHGHG 145
>SPAC23C11.14 [P] KOG1483 Zn2+ transporter ZNT1 and related Cd2+/Zn2+
transporters (cation diffusion facilitator superfamily)
Length = 387
Score = 64.3 bits (155), Expect = 6e-10
Identities = 41/139 (29%), Positives = 62/139 (44%), Gaps = 2/139 (1%)
Query: 360 IFSFLLLNSAFMFVQXXXXXXXXXXXXXXXXXHMALDCTSLFLGLLAGVLSKYPASD-KY 418
I L ++ F F++ HM D SL + L A L+ + + KY
Sbjct: 10 IILLLGIDVTFFFIEIITGYAIDSLALIADSFHMLNDIVSLLVALWATRLAHSTSHEPKY 69
Query: 419 PFALGYLETIAGFTNGVLLIGIVIEIFIESFQRIFNPVTILGTTELLVVSILGLLVNVVG 478
+ E + +NGV LI + + IF+E+ +R P ++ T + V LGLL N VG
Sbjct: 70 TYGWQRAEILGALSNGVFLIALCMFIFMEAIERFIEPPSVSNPTLMFFVGSLGLLSNFVG 129
Query: 479 LCAF-DHGHAHGEHESNDN 496
+ F DHGH H + N
Sbjct: 130 IFLFHDHGHDHPHTHTAQN 148
>Hs20540985 [P] KOG1482 Zn2+ transporter
Length = 320
Score = 62.0 bits (149), Expect = 3e-09
Identities = 48/175 (27%), Positives = 77/175 (43%), Gaps = 8/175 (4%)
Query: 370 FMFVQXXXXXXXXXXXXXXXXXHMALDCTSLFLGLLAGVLSKYPASDKYPFALGYLETIA 429
FM + H+ +D TS L L + LS P S + F E I
Sbjct: 35 FMIAEVVGGHIAGSLAVVTDAAHLLIDLTSFLLSLFSLWLSSKPPSKRLTFGWHRAE-IL 93
Query: 430 GFTNGVLLIGIVIEIFIE-SFQRIFNPVTILGTTELLVVSILGLLVNVVGLCAFDH---G 485
G +L I +V + + + +R+ P + T +++VS + N+V G
Sbjct: 94 GALLSILCIWVVTGVLVYLACERLLYPDYQIQATVMIIVSSCAVAANIVLTVVLHQRCLG 153
Query: 486 HAHGEHESNDNMRGIFLHVLADTLGSVGVIISTLLTKIFKSQ--IFDPIASFFIA 538
H H E ++N ++R F+H L D S+ V+IS L+ FK + I DPI +F +
Sbjct: 154 HNHKEVQANASVRAAFVHALGDLFQSISVLISALII-YFKPEYKIADPICTFIFS 207
>Hs14141726 [P] KOG1483 Zn2+ transporter ZNT1 and related Cd2+/Zn2+
transporters (cation diffusion facilitator superfamily)
Length = 507
Score = 60.1 bits (144), Expect = 1e-08
Identities = 39/143 (27%), Positives = 59/143 (40%), Gaps = 11/143 (7%)
Query: 360 IFSFLLLNSAFMFVQXXXXXXXXXXXXXXXXXHMALDCTSLFLGLLAGVLSKYP-ASDKY 418
+ L L FM ++ HM D +L + L+A ++ A+ K
Sbjct: 11 LLCMLALTFMFMVLEVVVSRVTSSLAMLSDSFHMLSDVLALVVALVAERFARRTHATQKN 70
Query: 419 PFALGYLETIAGFTNGVLLIGIVIEIFIESFQRIFNPVTILGTTELLVVSILGLLVNVVG 478
F E + N + L G+ I +E+ +R P + +L V + GLLVNV+G
Sbjct: 71 TFGWIRAEVMGALVNAIFLTGLCFAILLEAIERFIEPHEMQQPLVVLGVGVAGLLVNVLG 130
Query: 479 LCAF----------DHGHAHGEH 491
LC F HGH+HG H
Sbjct: 131 LCLFHHHSGFSQDSGHGHSHGGH 153
>CE03664 [P] KOG1482 Zn2+ transporter
Length = 382
Score = 59.3 bits (142), Expect = 2e-08
Identities = 50/199 (25%), Positives = 87/199 (43%), Gaps = 17/199 (8%)
Query: 352 ATNKETKSIFSFLLLNSAFMFVQXXXXXXXXXXXXXXXXXHMALDCTSLFLGLLAGVLSK 411
+ + T+ ++ ++L FM + H+ D S+ + L + +++
Sbjct: 68 SNRRATRILWLTVVLCLFFMVCEVIGGVLAGSLAIVTDAAHLLTDFASVLISLFSLYIAR 127
Query: 412 YPASDKYPFALGYLETIAGFTNGVLLIGIVIEIFIE-SFQRIFNPVTILGTTELLVVSIL 470
P S K F E + F + V LI IV + + + RI + + + + + L
Sbjct: 128 RPPSQKMSFGFHRAEVLGAFFS-VFLIWIVTGVLVVLAIMRIVSGDYEVEGGIMALTAAL 186
Query: 471 GLLVNVVGLCAF-------------DHGHAHGE-HESNDNMRGIFLHVLADTLGSVGVII 516
G++VN+V L HGH+HG + N N+R F+HVL D L S+GV++
Sbjct: 187 GVVVNLVMLALLYFGGHSHSHGGGSSHGHSHGGGNGDNINVRAAFIHVLGDLLQSLGVLV 246
Query: 517 STLLTKIFKS-QIFDPIAS 534
+ L S I DPI +
Sbjct: 247 AALFIYFQPSWVIIDPICT 265
>Hs22041360 [P] KOG1483 Zn2+ transporter ZNT1 and related Cd2+/Zn2+
transporters (cation diffusion facilitator superfamily)
Length = 272
Score = 58.2 bits (139), Expect = 4e-08
Identities = 39/129 (30%), Positives = 58/129 (44%), Gaps = 3/129 (2%)
Query: 356 ETKSIFSFLLLNSAFMFVQXXXXXXXXXXXXXXXXXHMALDCTSLFLGLLAGVLSKYPAS 415
+T + L+L AF + +M D SL +GL AG +++ P
Sbjct: 7 KTCRLLFMLVLTVAFFVAELVSGYLGNSIALLSDSFNMLSDLISLCVGLSAGYIARRPTR 66
Query: 416 DKYPFALGYL--ETIAGFTNGVLLIGIVIEIFIESFQRIFNPVTILGTTELLVVSILGLL 473
+ GY E + +N V L + IF+E+ R+ P I +L+V +LGLL
Sbjct: 67 G-FSATYGYARAEVVGALSNAVFLTALCFTIFVEAVLRLARPERIDDPELVLIVGVLGLL 125
Query: 474 VNVVGLCAF 482
VNVVGL F
Sbjct: 126 VNVVGLLIF 134
>CE29581 [P] KOG1483 Zn2+ transporter ZNT1 and related Cd2+/Zn2+
transporters (cation diffusion facilitator superfamily)
Length = 561
Score = 56.6 bits (135), Expect = 1e-07
Identities = 33/103 (32%), Positives = 54/103 (52%), Gaps = 10/103 (9%)
Query: 392 HMALDCTSLFLGLLAGVLSKYPASDKYPFALGY----LETIAGFTNGVLLIGIVIEIFIE 447
HMA D +L + ++ P++ LGY ET+ GF NG+ + + + +F E
Sbjct: 145 HMAADVMALIVAFTCIKIATRPST-----RLGYGWVRAETLGGFFNGIFMCTVCVLVFQE 199
Query: 448 SFQRIFNPVTILGTTELLVVSILGLLVNVVGLCAFD-HGHAHG 489
+ RI N I ++LV+ +GLL+N+ G+ HGH+HG
Sbjct: 200 AVGRIINVHMITHPLQVLVIGFIGLLINLFGMFNLSGHGHSHG 242
>CE27065 [P] KOG1483 Zn2+ transporter ZNT1 and related Cd2+/Zn2+
transporters (cation diffusion facilitator superfamily)
Length = 519
Score = 56.6 bits (135), Expect = 1e-07
Identities = 33/103 (32%), Positives = 54/103 (52%), Gaps = 10/103 (9%)
Query: 392 HMALDCTSLFLGLLAGVLSKYPASDKYPFALGY----LETIAGFTNGVLLIGIVIEIFIE 447
HMA D +L + ++ P++ LGY ET+ GF NG+ + + + +F E
Sbjct: 103 HMAADVMALIVAFTCIKIATRPST-----RLGYGWVRAETLGGFFNGIFMCTVCVLVFQE 157
Query: 448 SFQRIFNPVTILGTTELLVVSILGLLVNVVGLCAFD-HGHAHG 489
+ RI N I ++LV+ +GLL+N+ G+ HGH+HG
Sbjct: 158 AVGRIINVHMITHPLQVLVIGFIGLLINLFGMFNLSGHGHSHG 200
>HsM7019533 [P] KOG1482 Zn2+ transporter
Length = 429
Score = 51.6 bits (122), Expect = 4e-06
Identities = 42/166 (25%), Positives = 76/166 (45%), Gaps = 23/166 (13%)
Query: 392 HMALDCTSLFLGLLAGVLSKYPASDKYPFALGYLETIAGFTNGVLLIGIVIEIFIESFQR 451
HM D +++ L LLA LS + ++ F LE ++ + +L+ ++ + E+ QR
Sbjct: 146 HMLTDLSAIILTLLALWLSSKSPTKRFTFGFHRLEVLSAMISVLLVYILMGFLLYEAVQR 205
Query: 452 IFNPVTILGTTELLVVSILGLLVNVV-GLCAFDHGHAHGEHESNDN-------------- 496
+ + +L+ + +G+ VNV+ G GH H S +
Sbjct: 206 TIHMNYEINGDIMLITAAVGVAVNVIMGFLLNQSGHRHSHSHSLPSNSPTRGSGCERNHG 265
Query: 497 -----MRGIFLHVLADTLGSVGVIISTLLTKIFKSQ--IFDPIASF 535
+R F+H L D + SVGV+I+ + + FK + I DPI ++
Sbjct: 266 QDSLAVRAAFVHALGDLVQSVGVLIAAYIIR-FKPEYKIADPICTY 310
>Hs21359890 [P] KOG1482 Zn2+ transporter
Length = 429
Score = 51.6 bits (122), Expect = 4e-06
Identities = 42/166 (25%), Positives = 76/166 (45%), Gaps = 23/166 (13%)
Query: 392 HMALDCTSLFLGLLAGVLSKYPASDKYPFALGYLETIAGFTNGVLLIGIVIEIFIESFQR 451
HM D +++ L LLA LS + ++ F LE ++ + +L+ ++ + E+ QR
Sbjct: 146 HMLTDLSAIILTLLALWLSSKSPTKRFTFGFHRLEVLSAMISVLLVYILMGFLLYEAVQR 205
Query: 452 IFNPVTILGTTELLVVSILGLLVNVV-GLCAFDHGHAHGEHESNDN-------------- 496
+ + +L+ + +G+ VNV+ G GH H S +
Sbjct: 206 TIHMNYEINGDIMLITAAVGVAVNVIMGFLLNQSGHRHSHSHSLPSNSPTRGSGCERNHG 265
Query: 497 -----MRGIFLHVLADTLGSVGVIISTLLTKIFKSQ--IFDPIASF 535
+R F+H L D + SVGV+I+ + + FK + I DPI ++
Sbjct: 266 QDSLAVRAAFVHALGDLVQSVGVLIAAYIIR-FKPEYKIADPICTY 310
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.323 0.138 0.398
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,532,610
Number of Sequences: 60738
Number of extensions: 978952
Number of successful extensions: 2436
Number of sequences better than 1.0e-05: 23
Number of HSP's better than 0.0 without gapping: 7
Number of HSP's successfully gapped in prelim test: 16
Number of HSP's that attempted gapping in prelim test: 2382
Number of HSP's gapped (non-prelim): 41
length of query: 703
length of database: 30,389,216
effective HSP length: 113
effective length of query: 590
effective length of database: 23,525,822
effective search space: 13880234980
effective search space used: 13880234980
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)