ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactVI5746 good O KOG2708 Posttranslational modification, protein turnover, chaperones Predicted metalloprotease with chaperone activity (RNAse H/HSP70 fold)
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactVI5746 2001134 1999980 -385
(385 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YKR038c [O] KOG2708 Predicted metalloprotease with chaperone act... 636 0.0
SPBC16D10.03 [O] KOG2708 Predicted metalloprotease with chaperon... 432 e-121
Hs8923380 [O] KOG2708 Predicted metalloprotease with chaperone a... 420 e-117
7294127 [O] KOG2708 Predicted metalloprotease with chaperone act... 420 e-117
At4g22720 [O] KOG2708 Predicted metalloprotease with chaperone a... 405 e-113
ECU09g0140 [O] KOG2708 Predicted metalloprotease with chaperone ... 368 e-102
CE27316 [O] KOG2708 Predicted metalloprotease with chaperone act... 166 7e-41
YDL104c [O] KOG2707 Predicted metalloprotease with chaperone act... 95 2e-19
At2g45270 [O] KOG2707 Predicted metalloprotease with chaperone a... 79 9e-15
SPCC1259.10 [O] KOG2707 Predicted metalloprotease with chaperone... 73 6e-13
Hs11641265 [O] KOG2707 Predicted metalloprotease with chaperone ... 73 8e-13
>YKR038c [O] KOG2708 Predicted metalloprotease with chaperone activity
(RNAse H/HSP70 fold)
Length = 421
Score = 636 bits (1640), Expect = 0.0
Identities = 313/386 (81%), Positives = 339/386 (87%), Gaps = 1/386 (0%)
Query: 1 MVNLNGIPPRGKRNYYLAIGLEGSANKLGVGIIKHPVLEKHEDSDLSYECDVEILANIRD 60
MVNLN IPP+ R+YY+A+GLEGSANKLGVGI+KHP+L KH +SDLSY+C+ E+L+NIRD
Sbjct: 36 MVNLNTIPPKNGRDYYIALGLEGSANKLGVGIVKHPLLPKHANSDLSYDCEAEMLSNIRD 95
Query: 61 TYVTPPGEGFLPRDTARHHRNWVVRIIRKALTEAKIDDPT-KIDVICFTRGPGMGAPLHC 119
TYVTPPGEGFLPRDTARHHRNW +R+I++AL EA I PT IDVICFT+GPGMGAPLH
Sbjct: 96 TYVTPPGEGFLPRDTARHHRNWCIRLIKQALAEADIKSPTLDIDVICFTKGPGMGAPLHS 155
Query: 120 VVIAARTLSLMWDIPLVGVNHCVGHIEMGREITGAKNPVVLYVSGGNTQVIAYSEKRYRI 179
VVIAART SL+WD+PLVGVNHC+GHIEMGREIT A+NPVVLYVSGGNTQVIAYSEKRYRI
Sbjct: 156 VVIAARTCSLLWDVPLVGVNHCIGHIEMGREITKAQNPVVLYVSGGNTQVIAYSEKRYRI 215
Query: 180 FGETLDIAIGNCLDRFARTLKIPNAPSPGYNIEQLAKQCKNKEKLVVLPYTVKGMDLSMS 239
FGETLDIAIGNCLDRFARTLKIPN PSPGYNIEQLAK+ +KE LV LPYTVKGMDLSMS
Sbjct: 216 FGETLDIAIGNCLDRFARTLKIPNEPSPGYNIEQLAKKAPHKENLVELPYTVKGMDLSMS 275
Query: 240 GILQYIDTLAXXXXXXXXXXXXXXXSRTGEQLVTVEDLCYSLQENLFAMLVEITERAMAH 299
GIL ID LA TGEQ VTVEDLCYSLQENLFAMLVEITERAMAH
Sbjct: 276 GILASIDLLAKDLFKGNKKNKILFDKTTGEQKVTVEDLCYSLQENLFAMLVEITERAMAH 335
Query: 300 VNSNQVLIVGGVGCNVRLQEMMAQMCKDRSNGQVHATDDRFCIDNGVMIAQAGLLEYRTG 359
VNSNQVLIVGGVGCNVRLQEMMAQMCKDR+NGQVHATD+RFCIDNGVMIAQAGLLEYR G
Sbjct: 336 VNSNQVLIVGGVGCNVRLQEMMAQMCKDRANGQVHATDNRFCIDNGVMIAQAGLLEYRMG 395
Query: 360 HFVKDLSETIVTQKFRTDEVYIAWRE 385
VKD SET+VTQKFRTDEVY AWR+
Sbjct: 396 GIVKDFSETVVTQKFRTDEVYAAWRD 421
>SPBC16D10.03 [O] KOG2708 Predicted metalloprotease with chaperone activity
(RNAse H/HSP70 fold)
Length = 346
Score = 432 bits (1110), Expect = e-121
Identities = 227/369 (61%), Positives = 276/369 (74%), Gaps = 28/369 (7%)
Query: 17 LAIGLEGSANKLGVGIIKHPVLEKHEDSDLSYECDVEILANIRDTYVTPPGEGFLPRDTA 76
+A+GLEGSANKLGVGII H D++ S +ILAN+R TY+TPPG+GFLP DTA
Sbjct: 6 IALGLEGSANKLGVGIILH-------DTNGS----AKILANVRHTYITPPGQGFLPSDTA 54
Query: 77 RHHRNWVVRIIRKALTEAKIDDPTKIDVICFTRGPGMGAPLHCVVIAARTLSLMWDIPLV 136
+HHR W++ +I++A EAKI ID ICFT+GPG+GAPL+ V + AR LSL+ PLV
Sbjct: 55 KHHRAWIIPLIKQAFAEAKISFKD-IDCICFTKGPGIGAPLNSVALCARMLSLIHKKPLV 113
Query: 137 GVNHCVGHIEMGREITGAKNPVVLYVSGGNTQVIAYSEKRYRIFGETLDIAIGNCLDRFA 196
VNHC+GHIEMGREITGA+NPVVLYVSGGNTQVIAYSEK+YRIFGETLDIAIGNCLDRFA
Sbjct: 114 AVNHCIGHIEMGREITGAQNPVVLYVSGGNTQVIAYSEKKYRIFGETLDIAIGNCLDRFA 173
Query: 197 RTLKIPNAPSPGYNIEQLAKQCKNKEKLVVLPYTVKGMDLSMSGILQYIDTLAXXXXXXX 256
R + + NAPSPGYNI Q AK+ K + + LPYTVKGMD S SG+L ++ A
Sbjct: 174 RIIGLSNAPSPGYNIMQEAKKGK---RFIELPYTVKGMDCSFSGLLSGVEAAA------- 223
Query: 257 XXXXXXXXSRTGEQLVTVEDLCYSLQENLFAMLVEITERAMAHVNSNQVLIVGGVGCNVR 316
VT +DLCYSLQE FAMLVEITERAMAH+ ++ VLIVGGVGCN R
Sbjct: 224 ----TELLDPKNPSSVTKQDLCYSLQETGFAMLVEITERAMAHIRADSVLIVGGVGCNER 279
Query: 317 LQEMMAQMCKDRSNGQVHATDDRFCIDNGVMIAQAGLLEYRTGHFVKDLSETIVTQKFRT 376
LQ+MMA+M DR V +TD+RFCIDNG+MIAQAGLL Y+TG ++E+ +TQ++RT
Sbjct: 280 LQQMMAEMSSDR-GADVFSTDERFCIDNGIMIAQAGLLAYKTGDRCA-VAESTITQRYRT 337
Query: 377 DEVYIAWRE 385
D+VYI+WR+
Sbjct: 338 DDVYISWRD 346
>Hs8923380 [O] KOG2708 Predicted metalloprotease with chaperone activity
(RNAse H/HSP70 fold)
Length = 335
Score = 420 bits (1079), Expect = e-117
Identities = 223/367 (60%), Positives = 270/367 (72%), Gaps = 36/367 (9%)
Query: 19 IGLEGSANKLGVGIIKHPVLEKHEDSDLSYECDVEILANIRDTYVTPPGEGFLPRDTARH 78
+G EGSANK+GVG+++ D ++LAN R TYVTPPG GFLP DTARH
Sbjct: 5 LGFEGSANKIGVGVVR----------------DGKVLANPRRTYVTPPGTGFLPGDTARH 48
Query: 79 HRNWVVRIIRKALTEAKIDDPTKIDVICFTRGPGMGAPLHCVVIAARTLSLMWDIPLVGV 138
HR ++ ++++ALTE+ + ID I +T+GPGMGAPL V + ART++ +W+ PLVGV
Sbjct: 49 HRAVILDLLQEALTESGLTSQD-IDCIAYTKGPGMGAPLVSVAVVARTVAQLWNKPLVGV 107
Query: 139 NHCVGHIEMGREITGAKNPVVLYVSGGNTQVIAYSEKRYRIFGETLDIAIGNCLDRFART 198
NHC+GHIEMGR ITGA +P VLYVSGGNTQVIAYSE RYRIFGET+DIA+GNCLDRFAR
Sbjct: 108 NHCIGHIEMGRLITGATSPTVLYVSGGNTQVIAYSEHRYRIFGETIDIAVGNCLDRFARV 167
Query: 199 LKIPNAPSPGYNIEQLAKQCKNKEKLVVLPYTVKGMDLSMSGILQYIDTLAXXXXXXXXX 258
LKI N PSPGYNIEQ+AK+ K KLV LPYTVKGMD+S SGIL +I+ +A
Sbjct: 168 LKISNDPSPGYNIEQMAKRGK---KLVELPYTVKGMDVSFSGILSFIEDVAHRMLA---- 220
Query: 259 XXXXXXSRTGEQLVTVEDLCYSLQENLFAMLVEITERAMAHVNSNQVLIVGGVGCNVRLQ 318
TGE T EDLC+SLQE +FAMLVEITERAMAH S + LIVGGVGCNVRLQ
Sbjct: 221 --------TGE--CTPEDLCFSLQETVFAMLVEITERAMAHCGSQEALIVGGVGCNVRLQ 270
Query: 319 EMMAQMCKDRSNGQVHATDDRFCIDNGVMIAQAGLLEYRTGHFVKDLSETIVTQKFRTDE 378
EMMA MC++R ++ ATD+RFCIDNG MIAQAG +R GH LS++ VTQ++RTDE
Sbjct: 271 EMMATMCQER-GARLFATDERFCIDNGAMIAQAGWEMFRAGHRT-PLSDSGVTQRYRTDE 328
Query: 379 VYIAWRE 385
V + WR+
Sbjct: 329 VEVTWRD 335
>7294127 [O] KOG2708 Predicted metalloprotease with chaperone activity
(RNAse H/HSP70 fold)
Length = 347
Score = 420 bits (1079), Expect = e-117
Identities = 217/371 (58%), Positives = 274/371 (73%), Gaps = 31/371 (8%)
Query: 18 AIGLEGSANKLGVGIIKHPVLEKHEDSDLSYECDVEILANIRDTYVTPPGEGFLPRDTAR 77
A+G+EGSANK+G+GII+ D ++LAN+R TY+TPPGEGFLP++TA+
Sbjct: 4 ALGIEGSANKIGIGIIR----------------DGKVLANVRRTYITPPGEGFLPKETAK 47
Query: 78 HHRNWVVRIIRKALTEAKIDDPTKIDVICFTRGPGMGAPLHCVVIAARTLSLMWDIPLVG 137
HHR ++ ++ +L EA++ + +DVIC+T+GPGM PL I ARTLSL+W+IPL+G
Sbjct: 48 HHREAILGLVESSLKEAQLKS-SDLDVICYTKGPGMAPPLLVGAIVARTLSLLWNIPLLG 106
Query: 138 VNHCVGHIEMGREITGAKNPVVLYVSGGNTQVIAYSEKRYRIFGETLDIAIGNCLDRFAR 197
VNHC+GHIEMGR ITGA+NP VLYVSGGNTQVIAYS KRYRIFGET+DIA+GNCLDRFAR
Sbjct: 107 VNHCIGHIEMGRLITGAQNPTVLYVSGGNTQVIAYSNKRYRIFGETIDIAVGNCLDRFAR 166
Query: 198 TLKIPNAPSPGYNIEQLAKQCKNKEKLVVLPYTVKGMDLSMSGILQYIDTLAXXXXXXXX 257
+K+ N PSPGYNIEQLA K+ + + LPY VKGMD+S SGIL YI+ LA
Sbjct: 167 IIKLSNDPSPGYNIEQLA---KSSNRYIKLPYVVKGMDVSFSGILSYIEDLA------EP 217
Query: 258 XXXXXXXSRTGEQLV---TVEDLCYSLQENLFAMLVEITERAMAHVNSNQVLIVGGVGCN 314
+ E+ V + DLCYSLQE +FAMLVEITERAMAH SN+VLIVGGVGCN
Sbjct: 218 GKRQNKRKKPQEEEVNNYSQADLCYSLQETIFAMLVEITERAMAHCGSNEVLIVGGVGCN 277
Query: 315 VRLQEMMAQMCKDRSNGQVHATDDRFCIDNGVMIAQAGLLEYRTGHFVKDLSETIVTQKF 374
RLQEMM MC++R G++ ATD+R+CIDNG+MIA AG +R+G + E+ VTQ+F
Sbjct: 278 ERLQEMMRIMCEER-GGKLFATDERYCIDNGLMIAHAGAEMFRSGTRM-PFEESYVTQRF 335
Query: 375 RTDEVYIAWRE 385
RTDEV ++WR+
Sbjct: 336 RTDEVLVSWRD 346
>At4g22720 [O] KOG2708 Predicted metalloprotease with chaperone activity
(RNAse H/HSP70 fold)
Length = 353
Score = 405 bits (1042), Expect = e-113
Identities = 214/369 (57%), Positives = 256/369 (68%), Gaps = 35/369 (9%)
Query: 17 LAIGLEGSANKLGVGIIKHPVLEKHEDSDLSYECDVEILANIRDTYVTPPGEGFLPRDTA 76
+AIG EGSANK+GVGI+ D ILAN R TY+TPPG GFLPR+TA
Sbjct: 6 IAIGFEGSANKIGVGIVT---------------LDGTILANPRHTYITPPGHGFLPRETA 50
Query: 77 RHHRNWVVRIIRKALTEAKIDDPTKIDVICFTRGPGMGAPLHCVVIAARTLSLMWDIPLV 136
HH + V+ +++ AL +++ P +ID IC+T+GPGMGAPL I R LS +W P+V
Sbjct: 51 HHHLDHVLPLVKSALETSQVT-PEEIDCICYTKGPGMGAPLQVSAIVVRVLSQLWKKPIV 109
Query: 137 GVNHCVGHIEMGREITGAKNPVVLYVSGGNTQVIAYSEKRYRIFGETLDIAIGNCLDRFA 196
VNHCV HIEMGR +TGA +PVVLYVSGGNTQVIAYSE RYRIFGET+DIA+GNCLDRFA
Sbjct: 110 AVNHCVAHIEMGRVVTGADDPVVLYVSGGNTQVIAYSEGRYRIFGETIDIAVGNCLDRFA 169
Query: 197 RTLKIPNAPSPGYNIEQLAKQCKNKEKLVVLPYTVKGMDLSMSGILQYIDTLAXXXXXXX 256
R LK+ N PSPGYNIEQLAK+ +N + LPY VKGMD+S SGIL YI+T A
Sbjct: 170 RVLKLSNDPSPGYNIEQLAKKGEN---FIDLPYAVKGMDVSFSGILSYIETTA------- 219
Query: 257 XXXXXXXXSRTGEQLVTVEDLCYSLQENLFAMLVEITERAMAHVNSNQVLIVGGVGCNVR 316
+ T DLCYSLQE +FAMLVEITERAMAH + VLIVGGVGCN R
Sbjct: 220 -------EEKLKNNECTPADLCYSLQETVFAMLVEITERAMAHCDKKDVLIVGGVGCNER 272
Query: 317 LQEMMAQMCKDRSNGQVHATDDRFCIDNGVMIAQAGLLEYRTGHFVKDLSETIVTQKFRT 376
LQEMM MC +R +G++ ATDDR+CIDNG MIA GLL + G + ++ TQ+FRT
Sbjct: 273 LQEMMRTMCSER-DGKLFATDDRYCIDNGAMIAYTGLLAFVNG-IETPIEDSTFTQRFRT 330
Query: 377 DEVYIAWRE 385
DEV+ WRE
Sbjct: 331 DEVHAVWRE 339
>ECU09g0140 [O] KOG2708 Predicted metalloprotease with chaperone activity
(RNAse H/HSP70 fold)
Length = 331
Score = 368 bits (945), Expect = e-102
Identities = 198/369 (53%), Positives = 248/369 (66%), Gaps = 40/369 (10%)
Query: 17 LAIGLEGSANKLGVGIIKHPVLEKHEDSDLSYECDVEILANIRDTYVTPPGEGFLPRDTA 76
+A+GLEGSANKLGVGI++ D EILAN R TY PPGEGF+P TA
Sbjct: 2 IAMGLEGSANKLGVGIMR----------------DDEILANERLTYAPPPGEGFIPVKTA 45
Query: 77 RHHRNWVVRIIRKALTEAKIDDPTKIDVICFTRGPGMGAPLHCVVIAARTLSLMWDIPLV 136
HHR+ ++ ++ +L +A +D +D+ C+T+GPGMG PL V ARTLSL + PLV
Sbjct: 46 EHHRSRILGLVAVSLEKAGVD-LDDVDIFCYTKGPGMGLPLSVVATVARTLSLYCNKPLV 104
Query: 137 GVNHCVGHIEMGREITGAKNPVVLYVSGGNTQVIAYSEKRYRIFGETLDIAIGNCLDRFA 196
VNHC+ HIEMGR IT A NPV+LY SGGNTQ+IAY +RY+IFGETLDIA+GNC+DRFA
Sbjct: 105 PVNHCIAHIEMGRFITKASNPVILYASGGNTQIIAYHNRRYKIFGETLDIAVGNCIDRFA 164
Query: 197 RTLKIPNAPSPGYNIEQLAKQCKNKEKLVVLPYTVKGMDLSMSGILQYIDTLAXXXXXXX 256
R LK+PN P+PG ++E+ AK KN + LPY VKGMD+S SGIL I
Sbjct: 165 RALKLPNFPAPGLSVERYAKLGKN---YIELPYVVKGMDVSFSGILSNI----------- 210
Query: 257 XXXXXXXXSRTGEQLVTVEDLCYSLQENLFAMLVEITERAMAHVNSNQVLIVGGVGCNVR 316
+ E DLCYSLQE +F+ LVE+TERAMA +S +VLIVGGVGCN+R
Sbjct: 211 -------KRKIAEDEQVKRDLCYSLQETVFSALVEVTERAMAFSSSKEVLIVGGVGCNLR 263
Query: 317 LQEMMAQMCKDRSNGQVHATDDRFCIDNGVMIAQAGLLEYRTGHFVKDLSETIVTQKFRT 376
LQEMM M ++R G +ATD+RFCIDNGVMIA G+L ++G K L E VTQ++RT
Sbjct: 264 LQEMMGIMARER-GGVCYATDERFCIDNGVMIAYVGMLMAKSGAAFK-LGECFVTQRYRT 321
Query: 377 DEVYIAWRE 385
D V + WR+
Sbjct: 322 DSVEVTWRD 330
>CE27316 [O] KOG2708 Predicted metalloprotease with chaperone activity
(RNAse H/HSP70 fold)
Length = 258
Score = 166 bits (419), Expect = 7e-41
Identities = 86/152 (56%), Positives = 106/152 (69%), Gaps = 17/152 (11%)
Query: 19 IGLEGSANKLGVGIIKHPVLEKHEDSDLSYECDVEILANIRDTYVTPPGEGFLPRDTARH 78
IG+EGSANK+GVGII+ V +L+N R T+ PPGEGF P +TA+H
Sbjct: 5 IGIEGSANKIGVGIIRDGV----------------VLSNPRATFHAPPGEGFRPTETAQH 48
Query: 79 HRNWVVRIIRKALTEAKIDDPT-KIDVICFTRGPGMGAPLHCVVIAARTLSLMWDIPLVG 137
HR +VR++ +A+ A I +P +ID I +T+GPGMGAPL I ARTLSL W P++
Sbjct: 49 HRQQIVRLVGEAIKLANIQNPELEIDGIAYTKGPGMGAPLQVGAIVARTLSLTWKKPIIP 108
Query: 138 VNHCVGHIEMGREITGAKNPVVLYVSGGNTQV 169
VNHCVGHIEMGR ITGA NPVVLYVSGGNTQ+
Sbjct: 109 VNHCVGHIEMGRLITGADNPVVLYVSGGNTQL 140
>YDL104c [O] KOG2707 Predicted metalloprotease with chaperone activity
(RNAse H/HSP70 fold)
Length = 407
Score = 95.1 bits (235), Expect = 2e-19
Identities = 84/328 (25%), Positives = 142/328 (42%), Gaps = 21/328 (6%)
Query: 54 ILANIRDTYVTPPGEGFLPRDTARHHRNWVVRIIRKALTEAKIDDPTKIDVICFTRGPGM 113
+LAN++DT + G +P HH+ + + +AL E+ + ID+IC TRGPGM
Sbjct: 61 VLANLKDTLDSIDEGGIIPTKAHIHHQARIGPLTERALIESNAREG--IDLICVTRGPGM 118
Query: 114 GAPLHCVVIAARTLSLMWDIPLVGVNHCVGHIEMGREITGAKNP----VVLYVSGGNTQ- 168
L + A+ L++ W+ PL+GV+H +GH+ + R T K P V L VSGG+T
Sbjct: 119 PGSLSGGLDFAKGLAVAWNKPLIGVHHMLGHLLIPRMGTNGKVPQFPFVSLLVSGGHTTF 178
Query: 169 VIAYSEKRYRIFGETLDIAIGNCLDRFARTLKIPNAPSPGYNIEQLAKQCKNKEKLVV-- 226
V++ + + I +T+DIA+G+ LD+ R L +E+ Q N + +
Sbjct: 179 VLSRAIDDHEILCDTIDIAVGDSLDKCGRELGF-KGTMIAREMEKFINQDINDQDFALKL 237
Query: 227 -LPYTVKGMDLSMSGILQYIDTLAXXXXXXXXXXXXXXXSRTGEQLVTVEDLCYSLQENL 285
+P +K + + E+ + + Y +QE++
Sbjct: 238 EMPSPLKNSASKRNMLSFSFSAFITALRTNLTKLGKTEIQELPER--EIRSIAYQVQESV 295
Query: 286 FAMLVE-----ITERAMAHVNSNQVLIVGGVGCNVRLQ---EMMAQMCKDRSNGQVHATD 337
F ++ + + N + + GGV N RL+ E S +
Sbjct: 296 FDHIINKLKHVLKSQPEKFKNVREFVCSGGVSSNQRLRTKLETELGTLNSTSFFNFYYPP 355
Query: 338 DRFCIDNGVMIAQAGLLEYRTGHFVKDL 365
C DN +MI AG+ + + V DL
Sbjct: 356 MDLCSDNSIMIGWAGIEIWESLRLVSDL 383
>At2g45270 [O] KOG2707 Predicted metalloprotease with chaperone activity
(RNAse H/HSP70 fold)
Length = 463
Score = 79.3 bits (194), Expect = 9e-15
Identities = 81/354 (22%), Positives = 148/354 (40%), Gaps = 44/354 (12%)
Query: 17 LAIGLEGSANKLGVGIIKHPVLEKHEDSDLSYECDVEILANIRDTYVTPPGEGFLPRDTA 76
+ +G+E S + ++ + LS C E+L G P+
Sbjct: 85 VVLGIETSCDDTAAAVVS-------PFNHLSSSCRAELLVQYG---------GVAPKQAE 128
Query: 77 RHHRNWVVRIIRKALTEAKIDDPTKIDVICFTRGPGMGAPLHCVVIAARTLSLMWDIPLV 136
H + ++++ AL +A + + + + T GPG+ L V AR ++ + +P+V
Sbjct: 129 EAHSRVIDKVVQDALDKANLTEKD-LSAVAVTIGPGLSLCLRVGVRKARRVAGNFSLPIV 187
Query: 137 GVNHCVGHIEMGREITGAKNP--VVLYVSGG-NTQVIAYSEKRYRIFGETLDIAIGNCLD 193
GV+H H + R + + + L +SGG N V+A+ +Y G T+D AIG D
Sbjct: 188 GVHHMEAHALVARLVEQELSFPFMALLISGGHNLLVLAHKLGQYTQLGTTVDDAIGEAFD 247
Query: 194 RFARTLKIPNAPSPGYNIEQLAKQCKNKEKLVVLPYTV-KGMDLSMSGILQYIDTLAXXX 252
+ A+ L + S G +E+LA + K +P K + S +G+ +
Sbjct: 248 KTAKWLGLDMHRSGGPAVEELALEGDAKSVKFNVPMKYHKDCNFSYAGLKTQV------- 300
Query: 253 XXXXXXXXXXXXSRTGEQLVTVEDLCYSLQENLFAMLVEITERAM-----AHVNSNQVLI 307
+ +++ D+ S Q L E ERA+ + ++I
Sbjct: 301 ----------RLAIEAKEIRNRADIAASFQRVAVLHLEEKCERAIDWALELEPSIKHMVI 350
Query: 308 VGGVGCNVRLQEMMAQMCKDRSNGQVHATDDRFCIDNGVMIAQAGLLEYRTGHF 361
GGV N ++ + + +++ N ++ C DNGVM+A GL +R G +
Sbjct: 351 SGGVASNKYVRLRLNNIVENK-NLKLVCPPPSLCTDNGVMVAWTGLEHFRVGRY 403
>SPCC1259.10 [O] KOG2707 Predicted metalloprotease with chaperone activity
(RNAse H/HSP70 fold)
Length = 412
Score = 73.2 bits (178), Expect = 6e-13
Identities = 87/364 (23%), Positives = 149/364 (40%), Gaps = 44/364 (12%)
Query: 18 AIGLEGSANKLGVGIIKHPVLEKHEDSDLSYECDVEILA-NIRDTYVTPPGEGFL-PRDT 75
A+ +E S + V +++ SD S C EI+ N T G + P
Sbjct: 41 ALAIETSCDDTSVSVVR--------TSDSSSHCQNEIICLNTHRTISKYEAYGGIHPTIV 92
Query: 76 ARHHRNWVVRIIRKALTEAKIDDPTKIDVICFTRGPGMGAPLHCVVIAARTLSLMWDIPL 135
H+ + ++I++ +++A T D+I TRGPGM PL + A+ L++ PL
Sbjct: 93 IHEHQKNLAKVIQRTISDAARSGITDFDLIAVTRGPGMIGPLAVGLNTAKGLAVGLQKPL 152
Query: 136 VGVNHCVGHIEMGREITGAKNPVV-LYVSGGNTQVI-AYSEKRYRIFGETLDIAIGNCLD 193
+ V+H H + P + + VSGG+T ++ + S + I T DIA+G+ LD
Sbjct: 153 LAVHHMQAHALAVQLEKSIDFPYLNILVSGGHTMLVYSNSLLNHEIIVTTSDIAVGDYLD 212
Query: 194 RFARTLKIP-NAPSPGYNIEQLAKQCKNKEKLVVLP-------YTVKGMDLSMSGILQYI 245
+ A+ L IP + P +EQ A N + P V S SG+ Y
Sbjct: 213 KCAKYLGIPWDNEMPAAALEQFASPEINSTSYSLKPPIPLNTREKVHSASFSFSGLESYA 272
Query: 246 DTLAXXXXXXXXXXXXXXXSRTGEQLVTVEDLCYSLQENLFAMLVEITERAMAHVNSNQV 305
+ +T L + Y LQ F + + T A+ ++ ++V
Sbjct: 273 CRI---------------IRKTPLNLSEKKFFAYQLQYAAFQHICQKTLLALKRLDLSKV 317
Query: 306 ---LIVGGVGCNVRLQEMM------AQMCKDRSNGQVHATDDRFCIDNGVMIAQAGLLEY 356
+ GGV N L++M+ Q ++ ++ C DN MI + +
Sbjct: 318 KYLVCSGGVARNELLKKMLNDTLMVLQFEHQPTDIKLVYPSPDICSDNAAMIGYTAIQMF 377
Query: 357 RTGH 360
+ G+
Sbjct: 378 KAGY 381
>Hs11641265 [O] KOG2707 Predicted metalloprotease with chaperone activity
(RNAse H/HSP70 fold)
Length = 439
Score = 72.8 bits (177), Expect = 8e-13
Identities = 79/326 (24%), Positives = 136/326 (41%), Gaps = 38/326 (11%)
Query: 69 GFLPRDTARHHRNWVVRIIRKALTEAKIDDPTKIDVICFTRGPGMGAPLHCVVIAARTLS 128
G +P + HR + RI+++AL+ + + P+ + I T PG+ L + + L
Sbjct: 77 GIVPPAAQQLHRENIQRIVQEALSASGVS-PSDLSAIATTIKPGLALSLGVGLSFSLQLV 135
Query: 129 LMWDIPLVGVNHCVGHIEMGREITGAKNP-VVLYVSGGNTQV-IAYSEKRYRIFGETLDI 186
P + ++H H R + P +VL +SGG+ + + + + G++LDI
Sbjct: 136 GQLKKPFIPIHHMEAHALTIRLTNKVEFPFLVLLISGGHCLLALVQGVSDFLLLGKSLDI 195
Query: 187 AIGNCLDRFARTLKIPNAP-----SPGYNIEQLAKQCKNKEKLVVLP--YTVKGMDLSMS 239
A G+ LD+ AR L + P S G IE LAKQ N+ + P + K D S +
Sbjct: 196 APGDMLDKVARRLSLIKHPECSTMSGGKAIEHLAKQ-GNRFHFDIKPPLHHAKNCDFSFT 254
Query: 240 GILQYIDTLAXXXXXXXXXXXXXXXSR------------------TGEQLVTVEDLCYSL 281
G+ D + + G+ L + D+ ++
Sbjct: 255 GLQHVTDKIIMKKEKEEGIFLISKVEQINIPGLCLKIAAHFCRYEKGQILSSAADIAATV 314
Query: 282 QENLFAMLVEITERAMAHV-------NSNQVLIV-GGVGCNVRLQEMMAQMCKDRSNGQV 333
Q + LV+ T RA+ +N VL+ GGV N ++ + ++ + + +
Sbjct: 315 QHTMACHLVKRTHRAILFCKQRDLLPQNNAVLVASGGVASNFYIRRAL-EILTNATQCTL 373
Query: 334 HATDDRFCIDNGVMIAQAGLLEYRTG 359
R C DNG+MIA G+ R G
Sbjct: 374 LCPPPRLCTDNGIMIAWNGIERLRGG 399
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.321 0.139 0.416
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,613,765
Number of Sequences: 60738
Number of extensions: 934715
Number of successful extensions: 1795
Number of sequences better than 1.0e-05: 11
Number of HSP's better than 0.0 without gapping: 8
Number of HSP's successfully gapped in prelim test: 3
Number of HSP's that attempted gapping in prelim test: 1745
Number of HSP's gapped (non-prelim): 13
length of query: 385
length of database: 30,389,216
effective HSP length: 108
effective length of query: 277
effective length of database: 23,829,512
effective search space: 6600774824
effective search space used: 6600774824
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)