ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactVI5999 good LD KOG2045 Cell cycle control, cell division, chromosome partitioning 5'-3' exonuclease XRN1/KEM1/SEP1 involved in DNA strand exchange and mRNA turnover
r_klactVI5999 good LD KOG2045 Replication, recombination and repair 5'-3' exonuclease XRN1/KEM1/SEP1 involved in DNA strand exchange and mRNA turnover
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactVI5999 2091235 2095593 1453
(1453 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YGL173c [LD] KOG2045 5'-3' exonuclease XRN1/KEM1/SEP1 involved i... 1624 0.0
SPAC17A5.14 [LD] KOG2045 5'-3' exonuclease XRN1/KEM1/SEP1 involv... 928 0.0
CE26838 [LD] KOG2045 5'-3' exonuclease XRN1/KEM1/SEP1 involved i... 578 e-164
At5g42540 [LA] KOG2044 5'-3' exonuclease HKE1/RAT1 422 e-117
At1g75660 [LA] KOG2044 5'-3' exonuclease HKE1/RAT1 409 e-113
7293586 [LD] KOG2045 5'-3' exonuclease XRN1/KEM1/SEP1 involved i... 395 e-109
Hs18860916 [LA] KOG2044 5'-3' exonuclease HKE1/RAT1 378 e-104
7297186 [LA] KOG2044 5'-3' exonuclease HKE1/RAT1 377 e-104
CE22118 [LA] KOG2044 5'-3' exonuclease HKE1/RAT1 297 7e-80
At1g54490 [LA] KOG2044 5'-3' exonuclease HKE1/RAT1 292 3e-78
SPAC26A3.12c [LA] KOG2044 5'-3' exonuclease HKE1/RAT1 290 1e-77
YOR048c [LA] KOG2044 5'-3' exonuclease HKE1/RAT1 286 2e-76
Hs22041601 [LD] KOG2045 5'-3' exonuclease XRN1/KEM1/SEP1 involve... 188 6e-47
ECU09g0760 [LA] KOG2044 5'-3' exonuclease HKE1/RAT1 180 2e-44
>YGL173c [LD] KOG2045 5'-3' exonuclease XRN1/KEM1/SEP1 involved in DNA strand
exchange and mRNA turnover
Length = 1528
Score = 1624 bits (4206), Expect = 0.0
Identities = 828/1496 (55%), Positives = 1050/1496 (69%), Gaps = 86/1496 (5%)
Query: 1 MGIPKFFHFISERWPQISQLIDGSQIPEFDNLYLDMNSILHNCTHGDGSEVNSRLSEEEV 60
MGIPKFF +ISERWP I QLI+G+QIPEFDNLYLDMNSILHNCTHG+ +V RL+EEEV
Sbjct: 1 MGIPKFFRYISERWPMILQLIEGTQIPEFDNLYLDMNSILHNCTHGNDDDVTKRLTEEEV 60
Query: 61 YSKIFSYIDHLFHTIKPKQTFYMAIDGVAPRAKMNQQRARRFRTAMDAEKALQKAIENGD 120
++KI +YIDHLF TIKPK+ FYMAIDGVAPRAKMNQQRARRFRTAMDAEKAL+KAIENGD
Sbjct: 61 FAKICTYIDHLFQTIKPKKIFYMAIDGVAPRAKMNQQRARRFRTAMDAEKALKKAIENGD 120
Query: 121 ELPKGEPFDSNAITPGTEFMAKLTENLKYFIHDKITNDTRWQNVKVIFSGHEVPGEGEHK 180
E+PKGEPFDSN+ITPGTEFMAKLT+NL+YFIHDKI+ND++W+ V++IFSGHEVPGEGEHK
Sbjct: 121 EIPKGEPFDSNSITPGTEFMAKLTKNLQYFIHDKISNDSKWREVQIIFSGHEVPGEGEHK 180
Query: 181 IMDYIRAIRAQEDYNPNTRHCIYGLDADLIILGLSTHDHHFCLLREEVTFGKRSSSVKTL 240
IM++IR +++Q+D+N NTRHCIYGLDADLI+LGLSTH HF LLREEVTFG+R+S K+L
Sbjct: 181 IMNFIRHLKSQKDFNQNTRHCIYGLDADLIMLGLSTHGPHFALLREEVTFGRRNSEKKSL 240
Query: 241 ETQNFFLLHLSILREYLALEFEEITDSVQFEYDFERVLDDFIFVLFTIGNDFLPNLPDLH 300
E QNF+LLHLS+LREY+ LEF+EI D +QFEY+FER+LDDFI V+F IGNDFLPNLPDLH
Sbjct: 241 EHQNFYLLHLSLLREYMELEFKEIADEMQFEYNFERILDDFILVMFVIGNDFLPNLPDLH 300
Query: 301 LKKGAFPVLLQTFKEALQHMDGYINEQGKINLARFSIWLKYLSDFEYLNFEKKDIDVEWF 360
L KGAFPVLLQTFKEAL H DGYINE GKINL R +WL YLS FE LNFEK DIDVEWF
Sbjct: 301 LNKGAFPVLLQTFKEALLHTDGYINEHGKINLKRLGVWLNYLSQFELLNFEKDDIDVEWF 360
Query: 361 NQQLENISLEGERKRTRMGXXXXXXXXXXXIGAVKPWLLKTVQRKVTSELQDADFEIFPL 420
N+QLENISLEGERKR R+G IG++KPWL++ +Q K++ +L D + L
Sbjct: 361 NKQLENISLEGERKRQRVGKKLLVKQQKKLIGSIKPWLMEQLQEKLSPDLPDEEIPTLEL 420
Query: 421 EDKELVRANLDFLKEFAFDLGLILAHSKSKDLYYFKLDLDSINVQETDEEHEARIHETRR 480
++ +L+FLKEFAFDLGL + HSKSK Y K+DLDSIN ET+EE + R++ R+
Sbjct: 421 PKDLDMKDHLEFLKEFAFDLGLFITHSKSKGSYSLKMDLDSINPDETEEEFQNRVNSIRK 480
Query: 481 SIKKYEQGXXXXXXXXXXXXXXXXXXXFVEWKDQYYKDKLDFSINDTDSLKEMTENYVGG 540
+IKKY+ F WK +YY DKL F+ + + ++++ ++YV G
Sbjct: 481 TIKKYQNAIIVEDKEELETEKTIYNERFERWKHEYYHDKLKFTTDSEEKVRDLAKDYVEG 540
Query: 541 LQWVLYYYYRGCPSWSWYYRYHYAPRISDVIKGIDQNIEFHKGQPFKPFQQLMAVLPERS 600
LQWVLYYYYRGCPSWSWYY +HYAPRISD+ KG+DQ+IEF +PF PFQQLMAVLPERS
Sbjct: 541 LQWVLYYYYRGCPSWSWYYPHHYAPRISDLAKGLDQDIEFDLSKPFTPFQQLMAVLPERS 600
Query: 601 KNLIPVVYRPLMYDEHSPILDFYPNEVELDLNGKTADWEAVVKISFVDQKRLVEAMAPYD 660
KNLIP +RPLMYDE SPI DFYP EV+LD NGKTADWEAVV ISFVD+KRL+EAM PY
Sbjct: 601 KNLIPPAFRPLMYDEQSPIHDFYPAEVQLDKNGKTADWEAVVLISFVDEKRLIEAMQPYL 660
Query: 661 AKLSPDEKKRNSFGTDLIFIFNPQVDTVYKTPLAGLFNDIEHNHCIEREFIPESMENVKF 720
KLSP+EK RN FG DLI+ FNPQVD +YK+PL G+F+DIEHNHC+E+E+I +++ +
Sbjct: 661 RKLSPEEKTRNQFGKDLIYSFNPQVDNLYKSPLGGIFSDIEHNHCVEKEYITIPLDSSEI 720
Query: 721 LFGLPKGAKLGASSLAGFPSLKTLPLTAELAYNSSVVFNFPSKQQSMVLHIQDLYKENGI 780
+GL AKLGA LAGFP+L +LP T+ L YN ++VF PSKQQSMVL I D+YK N +
Sbjct: 721 RYGLLPNAKLGAEMLAGFPTLLSLPFTSSLEYNETMVFQQPSKQQSMVLQITDIYKTNNV 780
Query: 781 SLSDLAKRHMGKIVYSRWPFLRESKLLSLITEETVYEGVKSGKLTK--VIERKPQDFERK 838
+L D +KRH+ K++Y+RWP+LRESKL+SL +T+YE +S K I + + ++K
Sbjct: 781 TLEDFSKRHLNKVIYTRWPYLRESKLVSLTDGKTIYEYQESNDKKKFGFITKPAETQDKK 840
Query: 839 EFRELKMTLKSNYQRTKAILLDDISALAKVVPVNGLVRNSDGSYSKSFNETIEYYPLQLI 898
F LK ++ Y + KA+ + + A+A V PV GLVR+SDG Y K+F+ T +YYPLQL+
Sbjct: 841 LFNSLKNSMLRMYAKQKAVKIGPMEAIATVFPVTGLVRDSDGGYIKTFSPTPDYYPLQLV 900
Query: 899 VEDVKNKDERYIEKEPLPINKEFPKGSKVVFLGDYAYGGEATVDGYNSETRLKLTVKKGS 958
VE V N+DERY E+ P+PI +EFP SKV+FLGDYAYGGE T+DGY+S+ RLK+TV+K
Sbjct: 901 VESVVNEDERYKERGPIPIEEEFPLNSKVIFLGDYAYGGETTIDGYSSDRRLKITVEKKF 960
Query: 959 LRAEPNIGKVRAKLDSQALRFYPTQVFSKIARVHPLFLSKITSRYLVNDSKKKSHNVGLM 1018
L +EP IGK R ++D QA+++YP+ + SK +HPLFLSKITS++++ D+ K NVG+
Sbjct: 961 LDSEPTIGKERLQMDHQAVKYYPSYIVSKNMHLHPLFLSKITSKFMITDATGKHINVGIP 1020
Query: 1019 IKFKARNQKVLGYARCSSNKWEYSDVALGLLEQFRSTFPEFFAKLSNSKEQAIPSITDLF 1078
+KF+AR+QKVLGYAR + WEYS++ L LL+++R TFP+FF +LS IP + DLF
Sbjct: 1021 VKFEARHQKVLGYARRNPRGWEYSNLTLNLLKEYRQTFPDFFFRLSKVGND-IPVLEDLF 1079
Query: 1079 PNKSSAEADSILKTVADWLSEARKPFVVVSLESDSLTKASMAAVESEIIKYVSLPDSSEQ 1138
P+ S+ +A ++L + WL F+ VSLESDSLTK S+AAVE I+KY + + E+
Sbjct: 1080 PDTSTKDAMNLLDGIKQWLKYVSSKFIAVSLESDSLTKTSIAAVEDHIMKYAANIEGHER 1139
Query: 1139 KKLAKVPREAILNAESSYVLLRSQRFHLGDRVMYIQDSGKVPLHSKGTVVGYTSIGKNVS 1198
K+LAKVPREA+LN SS+ LLRSQ+F LGDRV+YIQDSGKVP+ SKGTVVGYT++ ++S
Sbjct: 1140 KQLAKVPREAVLNPRSSFALLRSQKFDLGDRVVYIQDSGKVPIFSKGTVVGYTTLSSSLS 1199
Query: 1199 IQVLFDNEIIAGNNFXXXXXXXXXXXXDSSFLLNLSDRQLVYHXXXXXXXXXXXXXVPND 1258
IQVLFD+EI+AGNNF D+SFLLN+++RQ +YH N
Sbjct: 1200 IQVLFDHEIVAGNNFGGRLRTNRGLGLDASFLLNITNRQFIYHSKASKKALEKKKQSNNR 1259
Query: 1259 KQVXXXXXXXXXXXXXXQ------AHELLNHIKKDNAESNTES----------------- 1295
+ AH+LLN IKKD E N+ES
Sbjct: 1260 NNNTKTAHKTPSKQQSEEKLRKERAHDLLNFIKKDTNEKNSESVDNKSMGSQKDSKPAKK 1319
Query: 1296 --------GSAPQIAVNTL--------NPSAANNVFNAVLNQIKP--GSQQQIQPPP--- 1334
S+ + V+ NP+ A ++FNAV NQ GS I PP
Sbjct: 1320 VLLKRPAQKSSENVQVDLANFEKAPLDNPTVAGSIFNAVANQYSDGIGSNLNIPTPPHPM 1379
Query: 1335 ---------AN-----SLPYNFTVPPHMV--PGGIPHPLMMQPPFIPNNEHIAYAAPPQ- 1377
AN LPYN +PP + P G+ HPL PN ++ P
Sbjct: 1380 NVVGGPIPGANDVADVGLPYN--IPPGFMTHPNGL-HPLHPHQMPYPNMNGMSIPPPAPH 1436
Query: 1378 --SQPVQNPP---------------LDKEASRNLKNLL--IRDENGRTANVENKDS 1414
QP+ PP ++++ S++LK + + NG T E K+S
Sbjct: 1437 GFGQPISFPPPPPMTNVSDQGSRIVVNEKESQDLKKFINGKQHSNGSTIGGETKNS 1492
>SPAC17A5.14 [LD] KOG2045 5'-3' exonuclease XRN1/KEM1/SEP1 involved in DNA strand
exchange and mRNA turnover
Length = 1328
Score = 928 bits (2398), Expect = 0.0
Identities = 520/1254 (41%), Positives = 740/1254 (58%), Gaps = 63/1254 (5%)
Query: 1 MGIPKFFHFISERWPQISQLIDGSQIPEFDNLYLDMNSILHNCTHGDGSEVNSRLSEEEV 60
MGIPKFF ++SER+P SQLI+ +IPEFDNLYLDMN ILHNCTH + + L EEE+
Sbjct: 1 MGIPKFFRWMSERYPLCSQLIENDRIPEFDNLYLDMNGILHNCTHKNDDHSSPPLPEEEM 60
Query: 61 YSKIFSYIDHLFHTIKPKQTFYMAIDGVAPRAKMNQQRARRFRTAMDAEKALQKAIENGD 120
Y IF+YI+HLF IKPK+ YMA+DG APRAKMNQQR+RRFRTA DA A KA NG+
Sbjct: 61 YIAIFNYIEHLFEKIKPKKLLYMAVDGCAPRAKMNQQRSRRFRTAKDAHDARLKAERNGE 120
Query: 121 ELPKGEPFDSNAITPGTEFMAKLTENLKYFIHDKITNDTRWQNVKVIFSGHEVPGEGEHK 180
+ P+ E FDSN ITPGT FM +++ L YFIH K+TND++WQN++VIFSGH+ PGEGEHK
Sbjct: 121 DFPE-EQFDSNCITPGTTFMERVSRQLYYFIHKKVTNDSQWQNIEVIFSGHDCPGEGEHK 179
Query: 181 IMDYIRAIRAQEDYNPNTRHCIYGLDADLIILGLSTHDHHFCLLREEVTFGKRSSS-VKT 239
IM+YIR +AQ YNPNTRHC+YGLDADLI+LGL +HD HFCLLREEVTFG S + K
Sbjct: 180 IMEYIRTQKAQPSYNPNTRHCLYGLDADLIMLGLLSHDPHFCLLREEVTFGPASRNRSKE 239
Query: 240 LETQNFFLLHLSILREYLALEFEEITDSVQFEYDFERVLDDFIFVLFTIGNDFLPNLPDL 299
L Q F+LLHLS+LREYL EF+E + F+YD E++LDDFI + F +GNDFLP+LP L
Sbjct: 240 LAHQKFYLLHLSLLREYLEFEFQECRSTFTFKYDLEKILDDFILLAFFVGNDFLPHLPGL 299
Query: 300 HLKKGAFPVLLQTFKEALQHMDGYINEQGKINLARFSIWLKYLSDFEYLNFEKKDIDVEW 359
H+ +GA ++ +K+ + GYINE+G IN+AR + L E NFEK E
Sbjct: 300 HINEGALALMFSIYKKVMPSAGGYINEKGVINMARLELIL-----LELENFEK-----EI 349
Query: 360 FNQQLENISLEGERKRTRMGXXXXXXXXXXXIGAV----KPWLLKTVQRKVTSELQDADF 415
F ++ G + I A+ K + L+ +++ ++S DF
Sbjct: 350 FKAEVSETKNNGNSDKPSFDFLKYITESTNDIKAMTGEQKNYFLQ-IKKFLSSREPFIDF 408
Query: 416 EIFPLEDKELVRANLDFLKEFAFDLGLILAHSKSKD-LYYFKLDLDSINVQETDEEHEAR 474
+ + FL+ DL L + D + ++ + + DE+ E
Sbjct: 409 SA------NISSVDQRFLRRLCNDLHLSFSKIIKVDGTHLLRITFRDLEFNDEDED-EIE 461
Query: 475 IHETRRSIKKYEQGXXXXXXXXXXXXXXXXXXXFVEWKDQYYKDKLDFSINDTDSLKEMT 534
E R ++KY+ F++WKD YY+ K+ FS D ++LK M
Sbjct: 462 QDEIERVLQKYDN--IPLLNEEQALKEKNVEKDFIQWKDDYYRSKVGFSYYDEEALKAMA 519
Query: 535 ENYVGGLQWVLYYYYRGCPSWSWYYRYHYAPRISDVIKGIDQNIEFHKGQPFKPFQQLMA 594
E YV GLQWVL+YYYRGC SW WYY YH+AP+ISDV+KG+D I+F G PF+PF+QLMA
Sbjct: 520 ERYVEGLQWVLFYYYRGCQSWGWYYNYHFAPKISDVLKGLDVKIDFKMGTPFRPFEQLMA 579
Query: 595 VLPERSKNLIPVVYRPLMYDEHSPILDFYPNEVELDLNGKTADWEAVVKISFVDQKRLVE 654
VLP RS+ L+P +R LM + SPI+DFYP LD NGKTA WEAVV I F+D+ RL++
Sbjct: 580 VLPARSQALVPPCFRDLMVNSESPIIDFYPENFALDQNGKTASWEAVVIIPFIDETRLID 639
Query: 655 AMAPYDAKLSPDEKKRNSFGTDLIFIFNPQVDTVYKTPLAGLFNDIEHNHCIEREFIPES 714
A+A D L+ +E+KRNSF +F + Y + L LF D+ CI++ + S
Sbjct: 640 ALASKDKFLTEEERKRNSFNAPTVFSLAEDYTSFYPSSLPSLFPDLV-TRCIQKPYSLPS 698
Query: 715 MENVKFLFGLPKGAKLGASSLAGFPSLKTLPLTAELAYNSSVVFNFPSKQQSMVLHIQDL 774
ME ++L GL G LGA + GFPS TL AEL Y+ VF S+ S++++++D+
Sbjct: 699 MEGKEYLVGLCPGVFLGAFGMVGFPSFHTLKHKAELVYHGINVFGNESRNPSVIVNVEDV 758
Query: 775 YKENGISLSDLAKRHMGKIVYSRWPFLRESKLLSLITEETVYEGVKSGKLTKVIERKPQD 834
++ ++ +A +++GK ++ WP+LRE+ + S + E +Y S + +R +
Sbjct: 759 --KSALTSEQIAMQYVGKRIFVDWPYLREAYVESAMDESYMYLASNS----TIEKRDLAE 812
Query: 835 FERKEFRELKMTLKSNYQRTKAILLDDISALAKVVPVNGLVRNSDGSYSKSFNETI-EYY 893
E+ ++ Y + +L DIS L +V P+ GL +G+ K FNE++ E Y
Sbjct: 813 IEKSQWGRKCSHKIREYSKRFGVLFGDISLLLQVRPIKGLEYTREGALVKIFNESVLEDY 872
Query: 894 PLQLIVEDVKNKDERYIEKEPLPINKEFPKGSKVVFLGDYAYGGEATVDGYNSETRLKLT 953
P QL+VE + D R+ E+E P+ E+P G+K LG+Y YG A + G +
Sbjct: 873 PAQLVVEKIAIDDPRFTEREAPPVEVEYPPGTKAFHLGEYNYGRPAQITGCKDNKLIIWL 932
Query: 954 VKKGSLRAEPNIGKVRAKLDSQALRFYPTQVFSKIARVHPLFLSKITSRYLVNDSKKKSH 1013
L A+ G+V ++YP+ + +K+ +HPL LSKITS +L+++ K+
Sbjct: 933 STAPGLDAQ--WGRVLVNDSKSKEKYYPSYIVAKLLNIHPLLLSKITSSFLISNGTKR-E 989
Query: 1014 NVGLMIKFKARNQKVLGYARCSSNKWEYSDVALGLLEQFRSTFPEFFAKLSNSKEQAIPS 1073
N+GL +KF ARNQKVLG++R S+ WE+S+ + L++++ +TFP+ F L+ + +
Sbjct: 990 NIGLNLKFDARNQKVLGFSRKSTKGWEFSNKTVALVKEYINTFPQLFNILTTHATKDNLT 1049
Query: 1074 ITDLFPNKSSAEADSILKTVADWLSEARKPFVVVSLESDSLTKASM--AAVESEIIKYV- 1130
+ D FP + + L V W+ E +SLT+ S+ A++S+IIK +
Sbjct: 1050 VKDCFPKDDTQQ----LAAVKHWIKEK---------GINSLTRVSLDEDALDSDIIKLIE 1096
Query: 1131 ---SLPDSSEQ--KKLAKVPREAILNAESSYVLLRSQRFHLGDRVMYIQDSGKVPLHSKG 1185
S DS+ Q KK+ VPR A+L + +L SQ F LGDRV+Y+QDSGKVP+ + G
Sbjct: 1097 EKASTIDSTYQVPKKVFGVPRYALLKPSQTRGILHSQEFALGDRVVYVQDSGKVPIAAYG 1156
Query: 1186 TVVGYTSIGKNVSIQVLFDNEIIAGNNFXXXXXXXXXXXXDSSFLLNLSDRQLV 1239
TVVG + V+FD ++G + S +LN+++ Q V
Sbjct: 1157 TVVGIML----HHLDVVFDLPFMSGTTLDGRCSPYHGMQVEVSMVLNVTNPQFV 1206
>CE26838 [LD] KOG2045 5'-3' exonuclease XRN1/KEM1/SEP1 involved in DNA strand
exchange and mRNA turnover
Length = 1209
Score = 578 bits (1491), Expect = e-164
Identities = 385/1160 (33%), Positives = 601/1160 (51%), Gaps = 118/1160 (10%)
Query: 1 MGIPKFFHFISERWPQISQLIDGSQIPEFDNLYLDMNSILHNCTHGDGSEVNSRLSEEEV 60
MG+PKF+ + SER+P +S++I+ SQIPEFDNLYLDMN I+HNC+H + +V R++E+E+
Sbjct: 1 MGVPKFYRWTSERYPCLSEVINESQIPEFDNLYLDMNGIIHNCSHPNDDDVTFRITEDEI 60
Query: 61 YSKIFSYIDHLFHTIKPKQTFYMAIDGVAPRAKMNQQRARRFR--------------TAM 106
+ IF+YI++L++ I+P++ F+MA+DGVAPRAKMNQQRARRF +A
Sbjct: 61 FVNIFAYIENLYNLIRPQKVFFMAVDGVAPRAKMNQQRARRFMYVEELLLAGKKEIWSAR 120
Query: 107 DAEKALQKAIENGDELPKGEPFDSNAITPGTEFMAKLTENLKYFIHDKITNDTRWQNVKV 166
A L KA+ENG+ +P FDSN ITPGT FM +L + L +I K D+RWQ K+
Sbjct: 121 TAHTQLAKALENGEIMPSEARFDSNCITPGTYFMTRLHQKLDDWIKTKSATDSRWQGRKI 180
Query: 167 IFSGHEVPGEGEHKIMDYIRAIRAQEDYNPNTRHCIYGLDADLIILGLSTHDHHFCLLRE 226
I SGH VPGEGEHKIMD+IR RA Y+PNTRHC+YGLDADLI+LG+ +H+ HF LLRE
Sbjct: 181 ILSGHNVPGEGEHKIMDFIRTERAGSSYDPNTRHCMYGLDADLIMLGIVSHEPHFSLLRE 240
Query: 227 EVTFGKRSSSVKTLET----------QNFFLLHLSILREYLALEFEEITDSVQFEYDFER 276
EVTF R T + F LLHLS+LREYLA EF ++ DS+ FEY+ ER
Sbjct: 241 EVTFNTRPRKNDNKATKKPKRTDSDVKKFHLLHLSLLREYLAWEFADVKDSLPFEYEMER 300
Query: 277 VLDDFIFVLFTIGNDFLPNLPDLHLKKGAFPVLLQTFKEALQHMDGYINEQGKINLARFS 336
++DD+I + +GNDFLP+LP++H+ A P+L T+K+ L +DGYINE G +NL+RF
Sbjct: 301 IVDDWILLGLLVGNDFLPHLPNIHIHDDALPLLYSTYKKVLPTLDGYINEAGYLNLSRFE 360
Query: 337 IWLKYLSDFEYLNFEKKDIDVEWFNQQLENISLEGERKRTRMGXXXXXXXXXXXIGAVKP 396
+L L+ + +F ++ D ++ E KR R+ V P
Sbjct: 361 AFLAELALNDKTSFMERLEDEQFM-----------ESKRIRV---------------VDP 394
Query: 397 WLLKTVQRK-VTSELQDADFEIFPLEDKELVRANLDFLKEFAFDLGLILAHSKSKDLYYF 455
+ + + V E D + E E K+ A ++ D + H + D
Sbjct: 395 EQQELAEPELVAFESSDVEDEAGAEESKD--EAGGAGAEDDEDDAAFVSDHEEDGDDLEP 452
Query: 456 KLDLDSINVQETDEE-HEARIHETRRSIKKYEQGXXXXXXXXXXXXXXXXXXXFVEWKDQ 514
D + + D + E ++ ++ F K
Sbjct: 453 GSGSDELLLSNLDAQLLEDEFNDELATLALSGMNDADFANDVEACWTKTINNQFKRHKKT 512
Query: 515 YYKDKLDFSINDTDSLKEMTENYVGGLQWVLYYYYRGCPSWSWYYRYHYAPRISDVIKGI 574
YY DKL + L+E E YV +QW L+YYY GC SWSW+Y +HYAP ISDV +
Sbjct: 513 YYSDKLRYKNISKQQLREQAEGYVRAIQWNLHYYYHGCVSWSWFYPHHYAPFISDVRGFV 572
Query: 575 DQNIEFHKGQPFKPFQQLMAVLPERSKNLIPVVYRPLMYDE--HSPILDFYPNEVELDLN 632
+EF +PF PF+QL+AVLPE S + +P R LM + SPI DFYP E DLN
Sbjct: 573 GMRMEFELSEPFHPFEQLLAVLPEASADCLPRPLRELMSSDPAKSPICDFYPANFETDLN 632
Query: 633 GKTADWEAVVKISFVDQKRLVEAMAPYDAKLSPDEKKRNSFGTDLIFIFNPQVDTVYKTP 692
GK +WEAVV I F+++KRL+EA+ ++L+ +E RNS G+ + I +P+
Sbjct: 633 GKRNEWEAVVLIPFIEEKRLLEAIEAKRSRLTSEENARNSHGSHIQCISSPEPPN----- 687
Query: 693 LAGLFNDIEHNHCIEREFIPESMENVKFLFGLPKGAKLGASSLAGFPSLKTLPLTAELAY 752
G + + + IP S + +GL K+ GFP++K L EL +
Sbjct: 688 SQGQWRTVRSEIPQDSFRIPRS----QVKWGLLPNVKMDV-YFPGFPTMKHLSHLGELRF 742
Query: 753 NSSVVFNFPSKQQSMVLHIQDLYKENGISLSDLAKRHMGKIVYSRWPFLRESKLLSLI-T 811
+ +F S+++SMVL +++ + + +L + V WP L+ +K+ S+
Sbjct: 743 ANCNIFGMASRKESMVLKVEN--ERAHTDIIELGSELCDEEVCIDWPILKVAKIDSIWGG 800
Query: 812 EETVYEGVKSGKLTKVIERKPQDFERKEFRELKMTLKSNYQRTKAILLDDIS-----ALA 866
++ + + K + + + + +L L + + A D A+A
Sbjct: 801 DDKIVRKCDDEIIVKDMSEEEKRQWQAHANQLTEHLMTRFAIEIAAQKDSKGKHIRPAVA 860
Query: 867 KVVPVNGLVRNSDG--------SYSKSFNETIEYYP--LQLIVEDVKNKDERYIEKEPLP 916
V GLV + G K ++ + P L L+V+DV ++ R + LP
Sbjct: 861 WVRKFTGLVYEAQGGGKEPSVLKACKQWSSPQQLMPVLLPLVVKDVLLENSRVL--ADLP 918
Query: 917 INKEFPKGSKVVFLGD---YAYGGEATVDGYNSETRLKLTVKKGSLRAEPNIGK---VRA 970
+ + +PK S +V++ D +G V+G+++E ++ + + + K +R
Sbjct: 919 MKQAYPKQS-IVWITDPKFALFGMPGMVNGFSNEKSADCRIEVIGMSTQNKVDKMEALRK 977
Query: 971 KLDSQALRFYPTQVFSKIARVHPLFLSKIT-SRYLVNDSKKKSH------------NVGL 1017
K++ ++LR+ ++ +V ++IT + +L N+ +++ N GL
Sbjct: 978 KMEQKSLRWMGGYDCARQCQVDTRLFARITGTMFLWNEPRERVEKGQQISSSDSKINCGL 1037
Query: 1018 MIKFKARNQKVLGYA--------RCSSNK-WEYSDVALGLLEQFRSTFPEFFAKLSN--- 1065
+K+ R+ V Y R +NK W Y+++A L+ ++R FP+ + L
Sbjct: 1038 ALKYSRRDLCVADYTDRTEHTNQRGVTNKVWFYTNLATRLVSEYRRKFPDVWKYLETIGL 1097
Query: 1066 SKEQAIPSITDLFPNKSSAE 1085
+++ + D++ N+ + E
Sbjct: 1098 TQQDDVYYTEDIWSNEKTRE 1117
>At5g42540 [LA] KOG2044 5'-3' exonuclease HKE1/RAT1
Length = 1012
Score = 422 bits (1085), Expect = e-117
Identities = 259/744 (34%), Positives = 401/744 (53%), Gaps = 107/744 (14%)
Query: 1 MGIPKFFHFISERWP-QISQLID---------GSQIP-----------EFDNLYLDMNSI 39
MG+P F+ ++ +R+P I ++I+ G IP E+DNLYLDMN I
Sbjct: 1 MGVPSFYRWLIQRYPLTIQEVIEEEPLEVNGGGVTIPIDSSKPNPNGYEYDNLYLDMNGI 60
Query: 40 LHNCTHGDGSEVNSRLSEEEVYSKIFSYIDHLFHTIKPKQTFYMAIDGVAPRAKMNQQRA 99
+H C H + S + EV+ +F YID LF ++P++ +MAIDGVAPRAKMNQQRA
Sbjct: 61 IHPCFHPEDKP--SPTTFTEVFQCMFDYIDRLFVMVRPRKLLFMAIDGVAPRAKMNQQRA 118
Query: 100 RRFRTAMDA------EKALQKAIEN-GDELPK---GEPFDSNAITPGTEFMAKLTENLKY 149
RRFR A DA E+ L++ E G +LP + FDSN ITPGTEFMA L+ L+Y
Sbjct: 119 RRFRAAKDAAEAAAEEEQLREEFEREGKKLPPKVDSQVFDSNVITPGTEFMATLSFALRY 178
Query: 150 FIHDKITNDTRWQNVKVIFSGHEVPGEGEHKIMDYIRAIRAQEDYNPNTRHCIYGLDADL 209
+IH ++ +D W+N+KVI S VPGEGEHKIM YIR + YNPNT HC+YGLDADL
Sbjct: 179 YIHVRLNSDPGWKNIKVILSDANVPGEGEHKIMSYIRCNKNHPGYNPNTHHCLYGLDADL 238
Query: 210 IILGLSTHDHHFCLLREEVTF-------------GKRSSSVK-----------------T 239
I+L L+TH+ HF +LRE V F G R++ +
Sbjct: 239 IMLSLATHEIHFSILREVVFFPGEEGKCFLCGQEGHRAADCEGKIKRKTGEMLDNTEADV 298
Query: 240 LETQNFFLLHLSILREYLALEFEEITDSVQFEYDFERVLDDFIFVLFTIGNDFLPNLPDL 299
+ + + +++ ILREYL E + + +R++DDFIF+ F +GNDFLP++P L
Sbjct: 299 VVKKPYEFVNIWILREYL----EHDMQIPGAKKNLDRLIDDFIFICFFVGNDFLPHMPTL 354
Query: 300 HLKKGAFPVLLQTFKEALQHMDGYINEQGKINLARFSIWLKYLSDFEYLNFEKKDIDVEW 359
+++GA +L+ +K + Y+ + K+NL ++K + +E F+K+ +
Sbjct: 355 EIREGAIELLMSVYKNKFRSAKKYLTDSSKLNLRNVERFIKAVGMYENQIFQKR---AQV 411
Query: 360 FNQQLENISLEGERKRTRMGXXXXXXXXXXXIGAVKPWLLKTVQRKVTSELQDADFEIFP 419
+Q E + R + R G K VQ E+ D+ +
Sbjct: 412 QQRQSERFRRDKARDKARDNARDNAQASRQFSG-------KLVQLDSLDEVSDS---LHS 461
Query: 420 LEDKELVRANLDFLKEFAFDLGLILAHSKSKDLYYFKLDLDSINVQETDEEHEARIHETR 479
++ +R +LD ++G+ ++ +S+ +E D E + + + +
Sbjct: 462 SPSRKYLRLSLD------DNIGVANVETE-----------NSLKAEELDNEEDLKF-KLK 503
Query: 480 RSIKKYEQGXXXXXXXXXXXXXXXXXXXFVEWKDQYYKDKLDF-SINDTDSL-KEMTENY 537
+ ++ G V W+++YY++K S+ + + + +++ Y
Sbjct: 504 KLLRDKGDGFRSGNGEQDKVKLNK-----VGWRERYYEEKFAAKSVEEMEQIRRDVVLKY 558
Query: 538 VGGLQWVLYYYYRGCPSWSWYYRYHYAPRISDVIKGIDQ-NIEFHKGQPFKPFQQLMAVL 596
GL W+++YYY G SW+W+Y YHYAP SD +KG+++ +I+F G PFKPF QL+AVL
Sbjct: 559 TEGLCWIMHYYYHGVCSWNWFYPYHYAPFASD-LKGLEKLDIKFELGSPFKPFNQLLAVL 617
Query: 597 PERSKNLIPVVYRPLMYDEHSPILDFYPNEVELDLNGKTADWEAVVKISFVDQKRLVEAM 656
P S + +P YR LM + SPI DFYP + E+D+NGK W+ + K+ FV++KRL+EA
Sbjct: 618 PSASAHALPECYRSLMTNPDSPIADFYPADFEIDMNGKRYSWQGISKLPFVEEKRLLEAA 677
Query: 657 APYDAKLSPDEKKRNSFGTDLIFI 680
A + L+ +E +RNS D++F+
Sbjct: 678 AQVEKSLTNEEIRRNSALFDMLFV 701
>At1g75660 [LA] KOG2044 5'-3' exonuclease HKE1/RAT1
Length = 985
Score = 409 bits (1051), Expect = e-113
Identities = 261/746 (34%), Positives = 388/746 (51%), Gaps = 103/746 (13%)
Query: 1 MGIPKFFHFISERWPQISQ--------LIDGSQIP-----------EFDNLYLDMNSILH 41
MG+P F+ +++E++P + I+G +IP E+DNLYLDMN I+H
Sbjct: 1 MGVPSFYRWLAEKYPLLVADVIEEEPVEIEGIKIPVDTSKPNPNNLEYDNLYLDMNGIIH 60
Query: 42 NCTHGDGSEVNSRLSEEEVYSKIFSYIDHLFHTIKPKQTFYMAIDGVAPRAKMNQQRARR 101
C H + S + EEV+ +F YID LF ++P++ YMAIDGVAPRAKMNQQR+RR
Sbjct: 61 PCFHPEDRP--SPTTFEEVFQCMFDYIDRLFVMVRPRKLLYMAIDGVAPRAKMNQQRSRR 118
Query: 102 FRTAMDA------EKALQKAIEN-GDELPK---GEPFDSNAITPGTEFMAKLTENLKYFI 151
FR+A DA E+ L++ E G LP + FDSN ITPGTEFM L+ L+Y++
Sbjct: 119 FRSAKDASDAAAEEERLREEFEREGRRLPPKVDSQVFDSNVITPGTEFMGVLSIALQYYV 178
Query: 152 HDKITNDTRWQNVKVIFSGHEVPGEGEHKIMDYIRAIRAQEDYNPNTRHCIYGLDADLII 211
H ++ +D W+N+KVI S VPGEGEHKIM YIR R ++PNTRHC+YGLDADLI+
Sbjct: 179 HLRLNHDVGWKNIKVILSDANVPGEGEHKIMSYIRLQRNLPGFDPNTRHCLYGLDADLIM 238
Query: 212 LGLSTHDHHFCLLREEV-TFG-----------------------KRSSSVKTLETQNFFL 247
LGL+TH+ HF +LRE V T G KR+ N F+
Sbjct: 239 LGLATHEVHFSILREVVYTPGQQERCFLCGQMGHFASNCEGKPKKRAGESDEKGDGNDFV 298
Query: 248 ------LHLSILREYLALEFEEITDSVQFEYDFERVLDDFIFVLFTIGNDFLPNLPDLHL 301
LH+ +LREYL LE + FE D ER++DDFIF+ F +GNDFLP++P L +
Sbjct: 299 KKPYQFLHIWVLREYLELEMR--IPNPPFEIDLERIVDDFIFICFFVGNDFLPHMPTLEI 356
Query: 302 KKGAFPVLLQTFKEALQHMDGYINEQGKINLARFSIWLKYLSDFEYLNFEKKDIDVEWFN 361
++GA +L+ +K+ + DGY+ + K NL R +++ + FE F+K+ +
Sbjct: 357 REGAINLLMAVYKKEFRSFDGYLTDGCKPNLKRVEQFIQAVGSFEDKIFQKRAMQ---HQ 413
Query: 362 QQLENISLEGERKRTRMGXXXXXXXXXXXIGAVKPWLLKTVQRKVTSELQDADFEIFPLE 421
+Q E + + K T+ + + + S Q D P +
Sbjct: 414 RQAERVKRDKAGKATKRMDDEAPTVQPDLVPVARFSGSRLASAPTPSPFQSNDGRSAPHQ 473
Query: 422 -------DKELVRANLDFLKEFAFDLGLILAHSKSKDLYYFKLDLDSINVQETDEEHEAR 474
+ A +D D K+K + D+ N +T EE + +
Sbjct: 474 KVRRLSPGSSVGAAIVDVENSLESDERENKEELKTKLKELIREKSDAFN-SDTTEEDKVK 532
Query: 475 IHETRRSIKKYEQGXXXXXXXXXXXXXXXXXXXFVEWKDQYYKDKLDFSINDTDSLKEMT 534
+ + + YE+ V ++ + + D + T+ L +
Sbjct: 533 LGQPGWRERYYEEKFS------------------VVTPEEMERVRKDVVLKYTEGLCWVM 574
Query: 535 ENYVGGLQWVLYYYYRGCPSWSWYYRYHYAPRISDVIKGIDQNIEFHKGQPFKPFQQLMA 594
Y+ G+ C SW W+Y YHYAP SD+ + +I+F G PFKPF QL+
Sbjct: 575 HYYMEGV----------C-SWQWFYPYHYAPFASDLKDLGEMDIKFELGTPFKPFNQLLG 623
Query: 595 VLPERSKNLIPVVYRPLMYDEHSPILDFYPNEVELDLNGKTADWEAVVKISFVDQKRLVE 654
V P S + +P YR LM D +SPI+DFYP + E+D+NGK W+ + K+ F+D++RL+E
Sbjct: 624 VFPAASSHALPERYRTLMTDPNSPIIDFYPTDFEVDMNGKRFSWQGIAKLPFIDERRLLE 683
Query: 655 AMAPYDAKLSPDEKKRNSFGTDLIFI 680
A++ + L+ +EK+RNS D++FI
Sbjct: 684 AVSEVEFTLTDEEKRRNSRMCDMLFI 709
>7293586 [LD] KOG2045 5'-3' exonuclease XRN1/KEM1/SEP1 involved in DNA
strand exchange and mRNA turnover
Length = 1612
Score = 395 bits (1014), Expect = e-109
Identities = 193/371 (52%), Positives = 266/371 (71%), Gaps = 5/371 (1%)
Query: 1 MGIPKFFHFISERWPQISQLIDGSQIPEFDNLYLDMNSILHNCTHGDGSEVNSRLSEEEV 60
MG+PKFF +ISER+P +S+L IPEFDNLYLDMN I+HNC+H D + ++ L EE++
Sbjct: 1 MGVPKFFRYISERYPCLSELAREHCIPEFDNLYLDMNGIVHNCSHPDDNNIHFHLEEEQI 60
Query: 61 YSKIFSYIDHLFHTIKPKQTFYMAIDGVAPRAKMNQQRARRFRTAMDAEKALQKAIENGD 120
+ +IF+Y+D LF+ IKP++ F++++DGVAPRAKMNQQR+RRFRTA +AE+ KA + G
Sbjct: 61 FQEIFNYVDKLFYLIKPQRLFFLSVDGVAPRAKMNQQRSRRFRTAREAEQQEAKAAQRG- 119
Query: 121 ELPKGEPFDSNAITPGTEFMAKLTENLKYFIHDKITNDTRWQNVKVIFSGHEVPGEGEHK 180
EL + E FDSN ITPGTEFM +L E L+ F+ KI+ D WQ VI SG E PGEGEHK
Sbjct: 120 ELREHERFDSNCITPGTEFMVRLQEGLRAFLKTKISTDPLWQRCTVILSGQEAPGEGEHK 179
Query: 181 IMDYIRAIRAQEDYNPNTRHCIYGLDADLIILGLSTHDHHFCLLREEVTFGKRSSSVKTL 240
IMDYIR ++ Q DY+PNTRHC+YGLDADLIILGL TH+ HF +LREEV FG+
Sbjct: 180 IMDYIRYMKTQPDYDPNTRHCLYGLDADLIILGLCTHELHFVVLREEVKFGRNVKRTSVE 239
Query: 241 ETQNFFLLHLSILREYLALEFEEI-TDSVQFEYDFERVLDDFIFVLFTIGNDFLPNLPDL 299
ET+ FFLLHL +LREYL LEF+ + TD + + D +++DD++ + F +GNDF+P+LP L
Sbjct: 240 ETR-FFLLHLGLLREYLELEFDALRTD--EHKLDIAQLIDDWVLMGFLVGNDFIPHLPCL 296
Query: 300 HLKKGAFPVLLQTFKEALQHMDGYINEQGKINLARFSIWLKYLSDFEYLNFEKKDIDVEW 359
H+ A P+L +T+ + G INE GK+NL R I++ L++ E +F++ D+++
Sbjct: 297 HISSNALPLLYRTYIGIYPTLGGNINENGKLNLRRLQIFISALTEVELDHFKEHADDLKY 356
Query: 360 FNQQLENISLE 370
N + E ++
Sbjct: 357 MNNKSEAFDMD 367
Score = 262 bits (669), Expect = 3e-69
Identities = 226/791 (28%), Positives = 383/791 (47%), Gaps = 71/791 (8%)
Query: 425 LVRANLDFLKEFAFDLGLILAHSKSKDLYYFKLDLDSINV-QETDEEHEARIHETRRSIK 483
L LD KE A DL + S++ F +D+ I Q D + A I+ +S+
Sbjct: 339 LTEVELDHFKEHADDLKYMNNKSEA-----FDMDVGEITESQNLDSDLGALIN---KSML 390
Query: 484 KYEQGXXXXXXXXXXXXXXXXXXXFVEWKDQYYKDKLDFSINDTDSLKEMTENYVGGLQW 543
Y+ F +K +Y++K ND + ++E+ +YV LQW
Sbjct: 391 LYDDDSEEDCSDENAVLLKE----FQNYKRNFYRNKFKRDPND-ELIEELCHHYVNALQW 445
Query: 544 VLYYYYRGCPSWSWYYRYHYAPRISDVIKGIDQ-NIEFHKGQPFKPFQQLMAVLPERSKN 602
VL YYYRG SW WYY +HY P ISD +K I+Q I FH G PF PFQQL+AVLP S
Sbjct: 446 VLDYYYRGVQSWDWYYPFHYTPFISD-LKNIEQVEIAFHMGTPFLPFQQLLAVLPAASAK 504
Query: 603 LIPVVYRPLMYDEHSPILDFYPNEVELDLNGKTADWEAVVKISFVDQKRLVEAMAPYDAK 662
L+PV Y LM SP+ +FYP E E DLNGK DWEAVV I F+D+ RL+ AM P +A+
Sbjct: 505 LLPVAYHDLMLLPTSPLAEFYPLEFESDLNGKKHDWEAVVLIPFIDEGRLLAAMLPCEAQ 564
Query: 663 LSPDEKKRNSFGTDLIFIFNPQVDTVYKTPLAGL--FNDIEHNHCIE-REFIPESMENVK 719
LS +E++RN G ++ ++ TV + P+ + +C E ++ E N+
Sbjct: 565 LSLEERERNRHGPMYVYKYS----TVAQGPMPAYPPLRALPVLYCTEVAKWSHEIAVNLP 620
Query: 720 F--LFGLPKGAKLGASSLAGFPSLKTLPLTAELAYNSSVVFNFPSKQQSMVLHIQDLYKE 777
+ LP A+ GFP+++ LP EL + VF S+ Q++VL + E
Sbjct: 621 YSVCIELPNAAR--TVFFPGFPTMQHLPFDFELRNDRVKVFEQVSRNQNIVLKPRKRQLE 678
Query: 778 NGISLSDLAKRHMGKIVYSRWPFLRESKLLSLITEETVYEGVKSGKLTKVIERKPQDFER 837
+ +L+ +A +++GK+++ WP L ++ ++ + T + + V S +T + + + D E
Sbjct: 679 D--TLTAVASQYLGKVIHVGWPHLVKAIVVRVATRD---QRVDSEGIT-LNDSRRFDSEC 732
Query: 838 KEFRE---LKMTLK-SNYQRTKAILLDDISALAKVVPVNGLVRNSDGS--YSKSFNETIE 891
K +E +M ++ +NY D+ + N G+ S++ ++
Sbjct: 733 KALQEHFINRMGIQFANY---------DVLVYVRTFAGNSTEFRDKGALMVRDSWSSSVT 783
Query: 892 YYPLQLIVEDVKNKDERYIEKEPLPINKEFPKGSKVVFLGDYAYGGEATVDGYN---SET 948
YP Q +V D+ + + K L + FP GS + + D YG E TV +
Sbjct: 784 GYPAQGVVADLTVWER--MRKNFLNVEHYFPVGSTIFLITDPYYGSEGTVQDPRLAYTNG 841
Query: 949 RLKLTVKKGSLRAEPNIGKVRAKLDSQALRFYPTQVFSKIARVHPLFLSKITSRYLVNDS 1008
R+++++ +R EP + R + + + T + R+ L +++ V
Sbjct: 842 RIQVSI---MVRPEPKVNAARQLQEERDRDYLSTFQVCNLLRISGRTLGRLSGTVWVVLG 898
Query: 1009 KKK-------SHNVGLMIKFKARNQKVLGYARCSSNKWEYSDVALGLLEQFRSTFPEFFA 1061
++ HN+GL +K+ +N++ GY ++N+W YS +A+ L+ + +P+
Sbjct: 899 PRRQKMENVTKHNIGLQLKYPRQNEERAGYCFRTNNQWYYSSLAVDLMRNYCQRYPDVID 958
Query: 1062 KLSNSKEQA-IPSITDLFPNKSSAEADSILKTVADWLSEARKPFVV-VSLESDSLTKASM 1119
+S ++A D+FPN A ++ +A+W+ + V +S S ++ + ++
Sbjct: 959 FFGDSNDRAEFVFEQDVFPN---AVGHRRVEELANWVRQQPHMKVERISCGSKTVCRETI 1015
Query: 1120 AAVESEIIKYVSLPDSSEQKKLAKVPREAILNAESSYVLLRSQR-FHLGDRVMYIQDSGK 1178
+ + + SLP + KL P I + + RS+R L DRV+ ++
Sbjct: 1016 ELLIAAVDDLRSLP--VKHVKLQVKPHLLIKPNVTLPDVYRSKRPVRLFDRVVIVRTIYM 1073
Query: 1179 VPLHSKGTVVG 1189
VP+ +KGTV+G
Sbjct: 1074 VPVGTKGTVIG 1084
>Hs18860916 [LA] KOG2044 5'-3' exonuclease HKE1/RAT1
Length = 950
Score = 378 bits (971), Expect = e-104
Identities = 272/831 (32%), Positives = 398/831 (47%), Gaps = 139/831 (16%)
Query: 1 MGIPKFFHFISERWPQI--------SQLIDGSQIP-----------EFDNLYLDMNSILH 41
MG+P FF ++S ++P I + +G +IP EFDNLYLDMN I+H
Sbjct: 1 MGVPAFFRWLSRKYPSIIVNCVEEKPKECNGVKIPVDASKPNPNDVEFDNLYLDMNGIIH 60
Query: 42 NCTHGDGSEVNSRLSEEEVYSKIFSYIDHLFHTIKPKQTFYMAIDGVAPRAKMNQQRARR 101
CTH + +E+E+ IF YID LF ++P++ YMAIDGVAPRAKMNQQR+RR
Sbjct: 61 PCTHPEDKPAPK--NEDEMMVAIFEYIDRLFSIVRPRRLLYMAIDGVAPRAKMNQQRSRR 118
Query: 102 FRTAMDA-EKALQKAIENGDELPKG---------EPFDSNAITPGTEFMAKLTENLKYFI 151
FR + + E A++K + L KG E FDSN ITPGTEFM L + L+Y+I
Sbjct: 119 FRASKEGMEAAVEKQRVREEILAKGGFLPPEEIKERFDSNCITPGTEFMDNLAKCLRYYI 178
Query: 152 HDKITNDTRWQNVKVIFSGHEVPGEGEHKIMDYIRAIRAQEDYNPNTRHCIYGLDADLII 211
D++ ND W+N+ VI S PGEGEHKIMDYIR RAQ +++PNT HC+ G DADLI+
Sbjct: 179 ADRLNNDPGWKNLTVILSDASAPGEGEHKIMDYIRRQRAQPNHDPNTHHCLCGADADLIM 238
Query: 212 LGLSTHDHHFCLLREEV------------TFGKRSSSVKTLETQ---------------- 243
LGL+TH+ +F ++REE FG + L +
Sbjct: 239 LGLATHEPNFTIIREEFKPNKPKPCGLCNQFGHEVKDCEGLPREKKGKHDELADSLPCAE 298
Query: 244 -NFFLLHLSILREYLALEFEEITDSVQFEYDFERVLDDFIFVLFTIGNDFLPNLPDLHLK 302
F L L++LREY LE E S+ F +D ER +DD++F+ F +GNDFLP+LP L ++
Sbjct: 299 GEFIFLRLNVLREY--LERELTMASLPFTFDVERSIDDWVFMCFFVGNDFLPHLPSLEIR 356
Query: 303 KGAFPVLLQTFKEALQHMDGYINEQGKINLARFSIWLKYLSDFEYLNFEKKDIDVEWFNQ 362
+ A L+ +K + GY+ E G +NL R + + + + E F+K+ D + F +
Sbjct: 357 ENAIDRLVNIYKNVVHKTGGYLTESGYVNLQRVQMIMLAVGEVEDSIFKKRKDDEDSFRR 416
Query: 363 QLENISLEGERKRTRMGXXXXXXXXXXXIGAVKPWLL---KTVQRKVTSELQDADFEI-F 418
+ + +RKR + G + P L + +V S + A +E+
Sbjct: 417 RQKE-----KRKRMKRDQPAFTPS-----GILTPHALGSRNSPGSQVASNPRQAAYEMRM 466
Query: 419 PLEDKELVRANLDFLKEFA-FDLGLILAHSKSKDLYYFKLDLDSINVQETDEEHEARIHE 477
+ N F + + LG I ++ D E + E R+ E
Sbjct: 467 QNNSSPSISPNTSFTSDGSPSPLGGIKRKAEDSD-------------SEPEPEDNVRLWE 513
Query: 478 TRRSIKKYEQGXXXXXXXXXXXXXXXXXXXFVEWKDQYYKDKLDFSINDTDSLKEMTENY 537
+ Y+ V+ D+ ++ K+ S + L + Y
Sbjct: 514 AGWKQRYYKNKFD------------------VDAADEKFRRKVVQSY--VEGLCWVLRYY 553
Query: 538 VGG-LQWVLYYYYRGCPSWSWYYRYHYAPRISDVIKGIDQNIEFHKG-QPFKPFQQLMAV 595
G W YY + HYAP SD D +F KG +PFKP +QLM V
Sbjct: 554 YQGCASWKWYYPF------------HYAPFASDFEGIADMPSDFEKGTKPFKPLEQLMGV 601
Query: 596 LPERSKNLIPVVYRPLMYDEHSPILDFYPNEVELDLNGKTADWEAVVKISFVDQKRLVEA 655
P S N +P +R LM D S I+DFYP + +DLNGK W+ V + FVD++RL A
Sbjct: 602 FPAASGNFLPPSWRKLMSDPDSSIIDFYPEDFAIDLNGKKYAWQGVALLPFVDERRLRAA 661
Query: 656 MAPYDAKLSPDEKKRNSFGTDLIFI--FNPQVDTVYKTPLAGLFNDIEHNHCIEREFIPE 713
+ L+P+E +RNS G D++F+ +P D + + G + E PE
Sbjct: 662 LEEVYPDLTPEETRRNSLGGDVLFVGKHHPLHDFILELYQTGSTEPV--------EVPPE 713
Query: 714 SMENVKFLFGLPKGAKLGASSLAGFPSLKTLPLTAELAYNSSVVFNFPSKQ 764
++ F L + A L + +P+ +L N+ V NF Q
Sbjct: 714 LCHGIQGKFSLDEEAILPDQIVC-----SPVPMLRDLTQNTVVSINFKDPQ 759
>7297186 [LA] KOG2044 5'-3' exonuclease HKE1/RAT1
Length = 885
Score = 377 bits (969), Expect = e-104
Identities = 248/743 (33%), Positives = 356/743 (47%), Gaps = 160/743 (21%)
Query: 1 MGIPKFFHFISERWPQI---------------SQLIDGSQIP-----EFDNLYLDMNSIL 40
MG+P FF ++S ++P + + + +P EFDNLYLDMN I+
Sbjct: 1 MGVPAFFRWLSRKYPSVIIECNENKQVDADTGRNIYEDPTLPNPNGIEFDNLYLDMNGII 60
Query: 41 HNCTHGDGSEVNSRLSEEEVYSKIFSYIDHLFHTIKPKQTFYMAIDGVAPRAKMNQQRAR 100
H CTH + +E+E+ IF ID LF ++P++ YMAIDGVAPRAKMNQQR+R
Sbjct: 61 HPCTHPEDKPAPK--NEDEMMVAIFECIDRLFGIVRPRKLLYMAIDGVAPRAKMNQQRSR 118
Query: 101 RFRTAMDA-EKALQKA------IENGDELP----KGEPFDSNAITPGTEFMAKLTENLKY 149
RFR A + EK L+ A + G +LP KGE FDSN ITPGT FM +L++ L Y
Sbjct: 119 RFRAAKETTEKRLEIARIREELLSRGCKLPPEKEKGEHFDSNCITPGTPFMDRLSKCLHY 178
Query: 150 FIHDKITNDTRWQNVKVIFSGHEVPGEGEHKIMDYIRAIRAQEDYNPNTRHCIYGLDADL 209
F+HD+ N+ W+ +KVI S VPGE H + G DADL
Sbjct: 179 FVHDRQNNNPAWKGIKVILSDANVPGE-----------------------HVLCGADADL 215
Query: 210 IILGLSTHDHHFCLLREEVT------------FGKRSSSVKTLETQ-------------- 243
I+LGL+TH+ +F ++REE FG L
Sbjct: 216 IMLGLATHEPNFTIIREEFLPNKPRPCDICNGFGHEMDKCVGLGATAPTSANFKPDVPIG 275
Query: 244 ---NFFLLHLSILREYLALEFEEITDSVQFEYDFERVLDDFIFVLFTIGNDFLPNLPDLH 300
F + LS+LREYL E ++ FEY FER LDD++F+ F +GNDFLP+LP L
Sbjct: 276 AEVKFIFVRLSVLREYLKQTLE--MPNLPFEYSFERALDDWVFMCFFVGNDFLPHLPSLE 333
Query: 301 LKKGAFPVLLQTFKEALQHMDGYINEQGKINLARFSIWLKYLSDFEYLNFEKKDIDVEWF 360
+++GA L++ +K+ + GY+ + G +NL R + + L + E F+ + E F
Sbjct: 334 IREGAVDRLVELYKKCVYKTRGYLTDSGDVNLDRVQLIMTDLGNAEDQIFKSRQRREEQF 393
Query: 361 NQQLENISLEGERKRTRMGXXXXXXXXXXXIGAVKPWLLKTVQRKVTSELQDADFEIFPL 420
+ + +++ R AV P + QR V + ++A
Sbjct: 394 KARDK-----ARKRQERNQDHGSLNQSAFGASAVGP---NSQQRSVGNYKEEA------- 438
Query: 421 EDKELVRANLDFLKEFAFDLGLILAHSKSKDLYYFKLDLDSINVQETDEEHEARIHETRR 480
L K D N+ + DEE E
Sbjct: 439 -----------------------------AALRNRKRTSDMANLDDEDEE------ENND 463
Query: 481 SIKKYEQGXXXXXXXXXXXXXXXXXXXFVEWKDQYYKDKLDFSINDTDSLKEMTENYVGG 540
++ +E G +KD+YY+ K D + + + YV G
Sbjct: 464 EVRLWEDG----------------------FKDRYYESKFDVAPGNQQFRYAVALQYVRG 501
Query: 541 LQWVLYYYYRGCPSWSWYYRYHYAPRISDVIKGIDQNIEFHKG-QPFKPFQQLMAVLPER 599
L WVL YYY+GC SW+WY+ YHYAP SD + + F KG +PF P +QLM V P
Sbjct: 502 LCWVLKYYYQGCASWNWYFPYHYAPFASDFVNIQGLSTMFEKGTKPFNPLEQLMGVFPAA 561
Query: 600 SKNLIPVVYRPLMYDEHSPILDFYPNEVELDLNGKTADWEAVVKISFVDQKRLVEAMAPY 659
S + +P + LM D SPI+DFYP + ++DLNGK W+ V + FVD+KRL +A+ PY
Sbjct: 562 SSSHVPEPWAKLMSDPESPIIDFYPEDFKIDLNGKKFAWQGVALLPFVDEKRLFKALVPY 621
Query: 660 DAKLSPDEKKRNSFGTDLIFIFN 682
+L+ +E KRN G + ++I N
Sbjct: 622 YDQLTGEEVKRNKRGDNYLYISN 644
>CE22118 [LA] KOG2044 5'-3' exonuclease HKE1/RAT1
Length = 892
Score = 297 bits (761), Expect = 7e-80
Identities = 162/421 (38%), Positives = 244/421 (57%), Gaps = 61/421 (14%)
Query: 1 MGIPKFFHFISERWPQI--------SQLIDGSQIP-----------EFDNLYLDMNSILH 41
MG+P FF ++++++P + DG+++P EFDNLYLDMN I+H
Sbjct: 1 MGVPAFFRWLTKKYPATVVNANEDRQRDQDGNRVPVDCTQPNPNFQEFDNLYLDMNGIIH 60
Query: 42 NCTHGDGSEVNSRLSEEEVYSKIFSYIDHLFHTIKPKQTFYMAIDGVAPRAKMNQQRARR 101
CTH + +E+E+++ IF YID ++ ++P++ YMAIDGVAPRAKMNQQR+RR
Sbjct: 61 PCTHPEDRPAPK--NEDEMFALIFEYIDRIYSIVRPRRLLYMAIDGVAPRAKMNQQRSRR 118
Query: 102 FRTAMDA-------EKALQKAIENGDELPKGEP----FDSNAITPGTEFMAKLTENLKYF 150
FR + + E+ + + G +P + FDSN ITPGT FMA+L + L+Y+
Sbjct: 119 FRASKEMAEKEASIEEQRNRLMAEGIAVPPKKKEEAHFDSNCITPGTPFMARLADALRYY 178
Query: 151 IHDKITNDTRWQNVKVIFSGHEVPGEGEHKIMDYIRAIRAQEDYNPNTRHCIYGLDADLI 210
IHD++TND W N+++I S VPGEGEHKIMDY+R R ++PNT HC+ G DADLI
Sbjct: 179 IHDRVTNDASWANIEIILSDANVPGEGEHKIMDYVRKQRGNPAHDPNTVHCLCGADADLI 238
Query: 211 ILGLSTHDHHFCLLREEVT------------FGKRSSSVKTLETQ--------------- 243
+LG++TH+ +F ++REE +G + E +
Sbjct: 239 MLGIATHEANFNIIREEFVPNQPRACDLCGQYGHELKECRGAENETDLGDDYCKPEQREK 298
Query: 244 NFFLLHLSILREYLALEFEEITDSVQFEYDFERVLDDFIFVLFTIGNDFLPNLPDLHLKK 303
NF L + +LREY LE E ++ F++D ER LDD++F+ F +GNDFLP+LP L +++
Sbjct: 299 NFIFLRIPVLREY--LEKELSMPNLPFKFDVERALDDWVFLCFFVGNDFLPHLPSLEIRE 356
Query: 304 GAFPVLLQTFKEALQHMDGYINEQGKINLARFSIWLKYLSDFEYLNFEKKDIDVEWFNQQ 363
GA L++ +KE + M GY+ + G L R + +K L E F+++ D E F +
Sbjct: 357 GAIDRLIKLYKEMVYQMKGYLTKDGIPELDRVEMIMKGLGRVEDEIFKRRQQDEERFQAR 416
Query: 364 L 364
+
Sbjct: 417 M 417
Score = 150 bits (379), Expect = 1e-35
Identities = 73/171 (42%), Positives = 103/171 (59%), Gaps = 1/171 (0%)
Query: 511 WKDQYYKDKLDFSINDTDSLKEMTENYVGGLQWVLYYYYRGCPSWSWYYRYHYAPRISDV 570
WKD+YY+ K D +D + + YV GL WVL YYY+GC SW WY+ YHYAP SD
Sbjct: 459 WKDRYYRAKFDVGSDDIEFRHRVAWAYVEGLCWVLRYYYQGCASWDWYFPYHYAPFASDF 518
Query: 571 IKGIDQNIEFHKG-QPFKPFQQLMAVLPERSKNLIPVVYRPLMYDEHSPILDFYPNEVEL 629
+ +F + +PF P +QLM+V P SK +PV ++ LM + SPI+D YP + +
Sbjct: 519 ETVGEFQPDFTRPTKPFNPLEQLMSVFPAASKQHLPVEWQKLMIQDDSPIIDLYPADFRI 578
Query: 630 DLNGKTADWEAVVKISFVDQKRLVEAMAPYDAKLSPDEKKRNSFGTDLIFI 680
DLNGK W+ V + FVD+ RL+ + L+ +EK+RN+ G + IFI
Sbjct: 579 DLNGKKYAWQGVALLPFVDETRLLATLQSVYPTLTAEEKQRNTRGPNRIFI 629
>At1g54490 [LA] KOG2044 5'-3' exonuclease HKE1/RAT1
Length = 947
Score = 292 bits (747), Expect = 3e-78
Identities = 162/408 (39%), Positives = 244/408 (59%), Gaps = 59/408 (14%)
Query: 1 MGIPKFFHFISERWPQ-ISQLID--------GSQIP-----------EFDNLYLDMNSIL 40
MG+P F+ ++++R+P+ IS +++ G IP EFDNLYLDMN I+
Sbjct: 1 MGVPAFYRWLADRYPKSISDVVEEEPTDGGRGDLIPVDITRPNPNGFEFDNLYLDMNGII 60
Query: 41 HNCTHGDGSEVNSRLSEEEVYSKIFSYIDHLFHTIKPKQTFYMAIDGVAPRAKMNQQRAR 100
H C H +G + + ++V+ +F YIDHLF ++P++ Y+AIDGVAPRAKMNQQR+R
Sbjct: 61 HPCFHPEGKPAPA--TYDDVFKSMFEYIDHLFTLVRPRKILYLAIDGVAPRAKMNQQRSR 118
Query: 101 RFRTAMDA------EKALQKAIENGDEL----PKGEPFDSNAITPGTEFMAKLTENLKYF 150
RFR A DA E+ L+K E ++ K E DSN ITPGT FMA L+ L+Y+
Sbjct: 119 RFRAAKDAAEAEAEEERLRKDFEMEGQILSAKEKAETCDSNVITPGTPFMAILSVALQYY 178
Query: 151 IHDKITNDTRWQNVKVIFSGHEVPGEGEHKIMDYIRAIRAQEDYNPNTRHCIYGLDADLI 210
I ++ ++ W+ VKVI S VPGEGEHKIM YIR R ++PNTRHC+YGLDADLI
Sbjct: 179 IQSRLNHNPGWRYVKVILSDSNVPGEGEHKIMSYIRLQRNLPGFDPNTRHCLYGLDADLI 238
Query: 211 ILGLSTHDHHFCLLREEVTF---------------------GKRSSSVKT----LETQNF 245
+L L+TH+ HF +LRE +T+ GK S+ + + +
Sbjct: 239 MLSLATHEVHFSILREVITYPGQQEKCFVCGQTGHFASDCPGKSGSNNAAADIPIHKKKY 298
Query: 246 FLLHLSILREYLALEFEEITDSVQFEYDFERVLDDFIFVLFTIGNDFLPNLPDLHLKKGA 305
L++ +LREY L++E F +FER++DDF+F+ F +GNDFLP++P L +++GA
Sbjct: 299 QFLNIWVLREY--LQYELAIPDPPFMINFERIIDDFVFLCFFVGNDFLPHMPTLEIREGA 356
Query: 306 FPVLLQTFKEALQHMDGYINEQGKINLARFSIWLKYLSDFEYLNFEKK 353
+L+ +++ M GY+ + G++ L R +++ ++ E F+K+
Sbjct: 357 INLLMHVYRKEFTAMGGYLTDSGEVLLDRVEHFIQAVAVNEDKIFQKR 404
Score = 155 bits (392), Expect = 4e-37
Identities = 76/172 (44%), Positives = 107/172 (62%), Gaps = 2/172 (1%)
Query: 511 WKDQYYKDKLDFSI-NDTDSLKE-MTENYVGGLQWVLYYYYRGCPSWSWYYRYHYAPRIS 568
+K++YY +K + +T+ +K+ M YV GL WV YYY+G SW W+Y YHYAP S
Sbjct: 444 YKERYYAEKFSTTNPEETEQIKQDMVLKYVEGLCWVCRYYYQGVCSWQWFYPYHYAPFAS 503
Query: 569 DVIKGIDQNIEFHKGQPFKPFQQLMAVLPERSKNLIPVVYRPLMYDEHSPILDFYPNEVE 628
D+ D I F G+PFKPF QLM LP S N +P YR LM D SPIL FYP + E
Sbjct: 504 DLKNLPDLEITFFIGEPFKPFDQLMGTLPAASSNALPGEYRKLMTDPSSPILKFYPADFE 563
Query: 629 LDLNGKTADWEAVVKISFVDQKRLVEAMAPYDAKLSPDEKKRNSFGTDLIFI 680
LD+NGK W+ + K+ F+++K L+ A + L+ +E++RNS DL+++
Sbjct: 564 LDMNGKRFAWQGIAKLPFIEEKLLLAATRKLEETLTVEEQQRNSVMLDLLYV 615
>SPAC26A3.12c [LA] KOG2044 5'-3' exonuclease HKE1/RAT1
Length = 991
Score = 290 bits (742), Expect = 1e-77
Identities = 160/396 (40%), Positives = 238/396 (59%), Gaps = 55/396 (13%)
Query: 1 MGIPKFFHFISERWPQI---------SQLIDGSQIP-----------EFDNLYLDMNSIL 40
MG+P F +S ++ ++ +L DG++I E DNLYLDMN I+
Sbjct: 1 MGVPALFRLLSRKFAKVITPVIEAPTEKLPDGTEIEPDLSLPNPNGVECDNLYLDMNGIV 60
Query: 41 HNCTHGDGSEVNSRLSEEEVYSKIFSYIDHLFHTIKPKQTFYMAIDGVAPRAKMNQQRAR 100
H C+H + +E+E+ +F Y D + ++P+Q ++AIDGVAPRAKMNQQR+R
Sbjct: 61 HPCSHPEDRPAPE--TEDEMMVAVFEYTDRILAMVRPRQLLFIAIDGVAPRAKMNQQRSR 118
Query: 101 RFRTAMDA-----------EKALQKAIENGDELPKGEPFDSNAITPGTEFMAKLTENLKY 149
RFR++ +A E+A Q+ I + K + +DSN ITPGT FM L ++L+Y
Sbjct: 119 RFRSSREAALKEEELQAFIEEAKQQGIPIDENATKKKSWDSNCITPGTPFMDTLAKSLRY 178
Query: 150 FIHDKITNDTRWQNVKVIFSGHEVPGEGEHKIMDYIRAIRAQEDYNPNTRHCIYGLDADL 209
+I +K+ +D W+NV+ I S VPGEGEHKIM++IR+ R + +Y+PNT H +YGLDADL
Sbjct: 179 YIINKLNSDPCWRNVRFILSDASVPGEGEHKIMEFIRSQRVKPEYDPNTHHVVYGLDADL 238
Query: 210 IILGLSTHDHHFCLLREEVTFGKRSSSVKTLE-------------------TQNFFLLHL 250
I+LGL+TH+ HF +LRE+V F ++ S+ KT E + F L++
Sbjct: 239 IMLGLATHEPHFRVLREDVFF-QQGSTKKTKEERLGIKRLDDVSETNKVPVKKPFIWLNV 297
Query: 251 SILREYLALEFEEITDSVQFEYDFERVLDDFIFVLFTIGNDFLPNLPDLHLKKGAFPVLL 310
SILREY LE E ++ F +D ER +DD++F +F +GNDFLP+LP L ++ GA L
Sbjct: 298 SILREY--LEVELYVPNLPFPFDLERAIDDWVFFIFFVGNDFLPHLPSLDIRDGAVERLT 355
Query: 311 QTFKEALQHMDGYINEQGKINLARFSIWLKYLSDFE 346
+ ++ +L HM GY+ G +NLAR + L + + E
Sbjct: 356 EIWRASLPHMGGYLTLDGSVNLARAEVILSAVGNQE 391
Score = 172 bits (435), Expect = 5e-42
Identities = 75/170 (44%), Positives = 114/170 (66%)
Query: 511 WKDQYYKDKLDFSINDTDSLKEMTENYVGGLQWVLYYYYRGCPSWSWYYRYHYAPRISDV 570
++++YY+ K S ++ + ++E ++YV GL WVL YYY+GCPSW+WYY YHYAP +D
Sbjct: 591 YRERYYEQKFHISPDEPEKIREAVKHYVHGLCWVLLYYYQGCPSWTWYYPYHYAPFAADF 650
Query: 571 IKGIDQNIEFHKGQPFKPFQQLMAVLPERSKNLIPVVYRPLMYDEHSPILDFYPNEVELD 630
+++F QPFKP++QL+ VLP SKN +P + LM DE+S I+DFYP +D
Sbjct: 651 KDLASIDVKFELNQPFKPYEQLLGVLPAASKNNLPEKLQTLMTDENSEIIDFYPENFTID 710
Query: 631 LNGKTADWEAVVKISFVDQKRLVEAMAPYDAKLSPDEKKRNSFGTDLIFI 680
LNGK +W+ V + F+D+ RL+ A++ +L+ +E KRN G+ L+FI
Sbjct: 711 LNGKKFEWQGVALLPFIDENRLLNAVSKIYPQLTEEESKRNEDGSTLLFI 760
>YOR048c [LA] KOG2044 5'-3' exonuclease HKE1/RAT1
Length = 1006
Score = 286 bits (732), Expect = 2e-76
Identities = 163/401 (40%), Positives = 234/401 (57%), Gaps = 50/401 (12%)
Query: 1 MGIPKFFHFISERWPQI--------SQLIDGSQIP----------EFDNLYLDMNSILHN 42
MG+P FF ++S ++P+I Q++DG +P E DNLYLDMN I+H
Sbjct: 1 MGVPSFFRWLSRKYPKIISPVLEEQPQIVDGVILPLDYSASNPNGELDNLYLDMNGIVHP 60
Query: 43 CTHGDGSEVNSRLSEEEVYSKIFSYIDHLFHTIKPKQTFYMAIDGVAPRAKMNQQRARRF 102
C+H + +E+E+ +F Y + + + +P++ MA+DGVAPRAKMNQQRARRF
Sbjct: 61 CSHPENKPPPE--TEDEMLLAVFEYTNRVLNMARPRKVLVMAVDGVAPRAKMNQQRARRF 118
Query: 103 RTAMDA-------EKALQKAIENG----DELPKGEPFDSNAITPGTEFMAKLTENLKYFI 151
R+A DA E+ +++ E G D + + +DSNAITPGT FM KL L+Y+
Sbjct: 119 RSARDAQIENEAREEIMRQREEVGEIIDDAVRNKKTWDSNAITPGTPFMDKLAAALRYWT 178
Query: 152 HDKITNDTRWQNVKVIFSGHEVPGEGEHKIMDYIRAIRAQEDYNPNTRHCIYGLDADLII 211
K+ D W+N++VI S VPGEGEHKIM++IR+ RA +YNPNT HCIYGLDADLI
Sbjct: 179 AFKLATDPGWKNLQVIISDATVPGEGEHKIMNFIRSQRADPEYNPNTTHCIYGLDADLIF 238
Query: 212 LGLSTHDHHFCLLREEV-------------TFGKRSSSVKTLETQN----FFLLHLSILR 254
LGL+TH+ HF +LRE+V T + L+ QN F LH+++LR
Sbjct: 239 LGLATHEPHFKILREDVFAQDNRKRNNLKDTINMTEEEKQFLQKQNSEQPFLWLHINVLR 298
Query: 255 EYLALEFEEITDSVQFEYDFERVLDDFIFVLFTIGNDFLPNLPDLHLKKGAFPVLLQTFK 314
EYL+ E + F +D ER +DD++F+ F GNDFLP+LP L +++ + +LL +K
Sbjct: 299 EYLSAEL--WVPGLPFTFDLERAIDDWVFMCFFCGNDFLPHLPCLDVRENSIDILLDIWK 356
Query: 315 EALQHMDGYINEQGKINLARFSIWLKYLSDFEYLNFEKKDI 355
L + Y+ G +NL L++L E F+ + I
Sbjct: 357 VVLPKLKTYMTCDGVLNLPSVETLLQHLGSREGDIFKTRHI 397
Score = 151 bits (381), Expect = 8e-36
Identities = 87/266 (32%), Positives = 144/266 (53%), Gaps = 12/266 (4%)
Query: 511 WKDQYYKDKLDFSINDTDSL-KEMTENYVGGLQWVLYYYYRGCPSWSWYYRYHYAPRISD 569
+ ++YY K + D + L K+M + Y+ G+ WVL YYY+GC SW+W+Y YHYAP +D
Sbjct: 604 YHERYYTAKFHVTPQDIEQLRKDMVKCYIEGVAWVLMYYYQGCASWNWFYPYHYAPLATD 663
Query: 570 VIKGIDQNIEFHKGQPFKPFQQLMAVLPERSKNLIPVVYRPLMYDEHSPILDFYPNEVEL 629
I+F +G PF P++QLM+VLP S + +P ++R LM + S I+DFYP E +
Sbjct: 664 FHGFSHLEIKFEEGTPFLPYEQLMSVLPAASGHALPKIFRSLMSEPDSEIIDFYPEEFPI 723
Query: 630 DLNGKTADWEAVVKISFVDQKRLVEAMAPYDAKLSPDEKKRNSFGTDLIFIFNPQVDTVY 689
D+NGK W+ + + F+DQ RL+ A+ LS E+ RN G ++ I N + Y
Sbjct: 724 DMNGKKMSWQGIALLPFIDQDRLLTAVRAQYPLLSDAERARNIRGEPVLLISNKNAN--Y 781
Query: 690 KTPLAGLFNDIEHNHCIEREF--IPESMENV--KFLFGLPKGAKLGASSLAG-FPSLKTL 744
+ L++ +N+ + +F + + K + G K+ G P+L T
Sbjct: 782 ERFSKKLYSKENNNNNVVVKFQHFKSGLSGIVSKDVEGFELNGKIVCPIQGGSLPNLST- 840
Query: 745 PLTAELAYNSSVVFNFPSKQQSMVLH 770
L +++Y + PS+ +S++L+
Sbjct: 841 TLILKMSYR---LIPLPSRNKSIILN 863
>Hs22041601 [LD] KOG2045 5'-3' exonuclease XRN1/KEM1/SEP1 involved in DNA strand
exchange and mRNA turnover
Length = 935
Score = 188 bits (477), Expect = 6e-47
Identities = 166/636 (26%), Positives = 304/636 (47%), Gaps = 56/636 (8%)
Query: 612 MYDEHSPILDFYPNEVELDLNGKTADWEAVVKISFVDQKRLVEAMAPYDAKLSPDEKKRN 671
M +E SPI+++YP + + DLNGK +WEAVV I F+D+ RL+EAM + L +E+KRN
Sbjct: 1 MTNEDSPIIEYYPPDFKTDLNGKQQEWEAVVLIPFIDE-RLLEAMETCNHSLKKEERKRN 59
Query: 672 SFGTDLIFIFNPQVDTVYKTPLAGLFNDIEHNHCIEREFIPESMENVKFLFGLPKGAKLG 731
L+ ++ + +Y +P F IE C R I S++ + K ++
Sbjct: 60 QHSECLMCWYDRDTEFIYPSPWPEKFPAIE--RCCTRYKI-ISLDAWRVDINKNKITRID 116
Query: 732 ASSL--AGFPSLKTLPLTAELAYNSSVVFNFPSKQQSMVLHIQDLYKENGISLSDLAKRH 789
+L GFP+LK + L + VF S+ ++M+L I + + +++ ++A
Sbjct: 117 QKALYFCGFPTLKHIRHKFFLKKSGVQVFQQSSRGENMMLEILVDAESDELTVENVASSV 176
Query: 790 MGKIVYSRWPFLRESKLLSLITEET------------VYEGVKSGKLTKVIERKPQDFER 837
+GK V+ WP L E++++++ ET +Y G ++ +KV+ D E+
Sbjct: 177 LGKSVFVNWPHLEEARVVAVSDGETKFYLEEPPGTQKLYSG-RTAPPSKVVHL--GDKEQ 233
Query: 838 KEFRELKMTLKSNYQRTKAILLDDISALAKVVPVNG----LVRNSDGSYSKSFNETIEYY 893
+ + + +Y R K I++++ SA+ + G + +N + K +++ + +
Sbjct: 234 SNWAKEVQGISEHYLRRKGIIINETSAVVYAQLLTGRKYQINQNGEVRLEKQWSKQVVPF 293
Query: 894 PLQLIVEDVKNKDERYIEKEPLPINKEFPKGSKVVFLGDYAYG--GEATVDG-YNSETRL 950
Q IV+D++ D R+ + L + FP S V LG YG GE G +E R+
Sbjct: 294 VYQTIVKDIRAFDSRFSNIKTL--DDLFPLRSMVFMLGTPYYGCTGEVQDSGDVITEGRI 351
Query: 951 KLTVKKGSLRAEPNIGKVRAKLDSQALRFYPTQVFSKIARVHPLFLSKIT-SRYLVNDSK 1009
++ S+ EPN+ + ++++ P V + V +S+ T S ++ S+
Sbjct: 352 RVIF---SIPCEPNLDALIQNQHKYSIKYNPGYVLASRLGVSGYLVSRFTGSIFIGRGSR 408
Query: 1010 KKSH-----NVGLMIKFKARNQKVLGYARCSSNKWEYSDVALGLLEQFRSTFPEFFAKLS 1064
+ H NVGL +KF +N++V GY + ++W YS A LL ++ PE F+ ++
Sbjct: 409 RNPHGDHKANVGLNLKFNKKNEEVPGYTKKVGSEWMYSSAAEQLLAEYLERAPELFSYIA 468
Query: 1065 NSKEQAIPSITDLFPNKSSAEADSILKTVADWLSEARKPFVVVSLESDSLTKASMAAVES 1124
+ ++ + D++P ++ A+ + + + WL P +S S L A VE
Sbjct: 469 KNSQEDVFYEDDIWPGENENGAEKV-QEIITWLK--GHPVSTLSRSSCDLQILDAAIVE- 524
Query: 1125 EIIKYVSLPDSSEQKKLAKVPREAI--------LNAESSYVLLRSQRFHLGDRVMYIQDS 1176
K + +Q+K K R + L + + R F L DRV+ ++++
Sbjct: 525 ---KIEEEVEKCKQRKNNKKVRVTVKPHLLYRPLEQQHGVIPDRDAEFCLFDRVVNVREN 581
Query: 1177 GKVPLHSKGTVVGYTSIGK--NVSIQVLFDNEIIAG 1210
VP+ +GT++G + +V +VLFD E G
Sbjct: 582 FSVPVGLRGTIIGIKGANREADVLFEVLFDEEFPGG 617
>ECU09g0760 [LA] KOG2044 5'-3' exonuclease HKE1/RAT1
Length = 655
Score = 180 bits (456), Expect = 2e-44
Identities = 128/427 (29%), Positives = 197/427 (45%), Gaps = 74/427 (17%)
Query: 1 MGIPKFFHFISERWPQISQLIDGSQI---PEFDNLYLDMNSILHNCTH-GDGSEVNSRLS 56
MG+P F RW Q+S I P D LYLD N+I+H C G GSE
Sbjct: 1 MGVPSLF-----RWLQLSHKETIHSIMEKPSVDALYLDFNAIIHTCIKPGLGSEEEI--- 52
Query: 57 EEEVYSKIFSYIDHLFHTIKPKQTFYMAIDGVAPRAKMNQQRARRFRTAM---------- 106
E ++Y + +IDH+ +P++ Y+A+DGVAPRAK++ QRARR+++A+
Sbjct: 53 ERDLYKTVGDFIDHILLKTRPRKLLYIAVDGVAPRAKLSHQRARRYKSALGKKEGSAVIA 112
Query: 107 --DAEKALQKAIENGDELP-----------------------------KGEPFDSNAITP 135
A+ + E DE+P + E FD N ITP
Sbjct: 113 AAKADPTMSSPSEKKDEIPNEEFTGESSLYDKFIAEDPSESSSLAIDVETEKFDLNCITP 172
Query: 136 GTEFMAKLTENLKYFIHDKITNDTRWQNVKVIFSGHEVPGEGEHKIMDYIRAIRAQEDYN 195
GT FM +L + L +I K+++D N+++I+S + VPGEGE KIM + IR+Q
Sbjct: 173 GTPFMERLHKVLISYIQCKLSSDPEVSNLRIIYSSYLVPGEGEQKIMSF---IRSQGSIA 229
Query: 196 PNTRHCIYGLDADLIILGLSTHDHHFCLLREEVT---------------FGKRSSSVKTL 240
N H IY D DLI LGLS + ++R+ + G
Sbjct: 230 RNDVHMIYSPDGDLIFLGLSLQRNRVLIMRDYFSPSKERRKRTCTKCGRTGHSDEECGVF 289
Query: 241 ETQNFFLLHLSILREYLALEFEEITDSVQFEYDFERVLDDFIFVLFTIGNDFLPNLPDLH 300
+F +++S LR L EF T + ER+LDD+IF+ F +GNDF+P +P L
Sbjct: 290 TNYHFVYVNISELRTRLIREFRRHTAQ---RFSEERILDDWIFLCFLLGNDFVPPIPCLD 346
Query: 301 LKKGAFPVLLQTFKEALQHMDGYINEQGKINLARFSIWLKYLSDFEYLNFEKKDIDVEWF 360
++ + + + ++ M YI IN + L+ E + +K ++ F
Sbjct: 347 IRFHSIETITEIMMKSFSEMKSYITCNKMINYQALRNFYAILASKEDGLYHRKSQSLDKF 406
Query: 361 NQQLENI 367
+ L+ +
Sbjct: 407 REGLKGM 413
Score = 107 bits (268), Expect = 1e-22
Identities = 56/168 (33%), Positives = 90/168 (53%), Gaps = 6/168 (3%)
Query: 512 KDQYYKDKLDFSINDTDSLKEMTENYVGGLQWVLYYYYRGCPSWSWYYRYHYAPRISDVI 571
K QYY KL+ + +K + YV GL WV YY G W WYY YH+AP +D+
Sbjct: 429 KVQYYTSKLNATTES--DIKNICYEYVKGLYWVYSYYVLGWTGWDWYYPYHFAPLAADLS 486
Query: 572 KGIDQNIEFHKGQPFKPFQQLMAVLPERSKNLIPVVYRPLMYDEHSPILDFYPNEVELDL 631
K +I+ G P +P +QL+ VLP S+ ++P +P+ +D++ D+YP +V+ D+
Sbjct: 487 KLSINDIQISPGHPLRPLEQLLVVLPPMSRGMVPEGLQPI-FDDYK---DYYPEDVKTDM 542
Query: 632 NGKTADWEAVVKISFVDQKRLVEAMAPYDAKLSPDEKKRNSFGTDLIF 679
K W+ +V + F+D + ++ A L ++ RN DL+F
Sbjct: 543 FDKVYLWQEIVLLPFMDFRPILSENAVKFNTLGYEDLSRNLRSLDLLF 590
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.317 0.136 0.393
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 83,155,488
Number of Sequences: 60738
Number of extensions: 3685242
Number of successful extensions: 11255
Number of sequences better than 1.0e-05: 14
Number of HSP's better than 0.0 without gapping: 13
Number of HSP's successfully gapped in prelim test: 1
Number of HSP's that attempted gapping in prelim test: 11148
Number of HSP's gapped (non-prelim): 35
length of query: 1453
length of database: 30,389,216
effective HSP length: 119
effective length of query: 1334
effective length of database: 23,161,394
effective search space: 30897299596
effective search space used: 30897299596
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)