ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactVI6407 good T KOG3872 Signal transduction mechanisms FOG: FHA domain
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactVI6407 2231049 2229496 -518
(518 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YNL116w [T] KOG3872 FOG: FHA domain 388 e-107
YHR115c [T] KOG3872 FOG: FHA domain 387 e-107
SPAC17G8.10c [T] KOG3872 FOG: FHA domain 173 6e-43
SPBC3H7.13 [T] KOG3872 FOG: FHA domain 60 1e-08
7289492_1 [T] KOG3872 FOG: FHA domain 55 3e-07
CE17187_1 [T] KOG3872 FOG: FHA domain 54 7e-07
YLR238w [T] KOG3872 FOG: FHA domain 50 6e-06
Hs6005864 [O] KOG4628 Predicted E3 ubiquitin ligase 50 6e-06
>YNL116w [T] KOG3872 FOG: FHA domain
Length = 522
Score = 388 bits (996), Expect = e-107
Identities = 183/280 (65%), Positives = 225/280 (80%), Gaps = 5/280 (1%)
Query: 165 TIPQNGQAL-KNVHHFIYPAVRPASAPSLHLDFAPDWAQPEA----ADDETVRNRKDKNG 219
TI N Q + KN+ H IY A +P LHLD A+ D+ T++ RKDK+G
Sbjct: 201 TIVNNSQEMYKNLRHLIYAANQPNGTEILHLDLPATSAEESNNMFNVDEVTLKQRKDKHG 260
Query: 220 LFTLRLTAFIDNSSAGNPGFYFDPIIRTAGPGSQLVIGRYTEKVREAISSIPEPFHPAVF 279
LF++RLT FID+SS N G +F+PIIR AGPGSQLVIGRYTE+VR+AIS IPE +HP VF
Sbjct: 261 LFSIRLTPFIDSSSTTNQGLFFEPIIRKAGPGSQLVIGRYTERVRDAISKIPEQYHPVVF 320
Query: 280 KSKVVSRTHGVFKVDDNGNWFVKDVKSSSGTFLNHQRLSQPATMSKDFLLKDGDILQLGL 339
KSKVVSRTHG FKVD GNW++KDVKSSSGTFLNHQRLS +++SKD L+DGDILQLG+
Sbjct: 321 KSKVVSRTHGCFKVDSQGNWYIKDVKSSSGTFLNHQRLSPASSLSKDTPLRDGDILQLGM 380
Query: 340 DFRGGAEEIYRCVKMRVELNKSWRRKANAFNKEAIQKMKALQKMTSGTELEDCSICLSKI 399
DFRGG EEIYRCV+MR+ELN+SW+ KAN+FNKEA+Q+++ LQK+T+G E EDCSICL KI
Sbjct: 381 DFRGGTEEIYRCVRMRIELNRSWKLKANSFNKEALQRLQNLQKLTTGIEEEDCSICLCKI 440
Query: 400 KACQAVFIAPCSHSWHFKCIRQLVSKTYPQFVCPNCRAVC 439
K CQA+FI+PC+HSWHF+C+R+LV +YPQFVCPNCR+ C
Sbjct: 441 KPCQAIFISPCAHSWHFRCVRRLVMLSYPQFVCPNCRSSC 480
>YHR115c [T] KOG3872 FOG: FHA domain
Length = 416
Score = 387 bits (994), Expect = e-107
Identities = 203/388 (52%), Positives = 254/388 (65%), Gaps = 31/388 (7%)
Query: 67 SNPVPNSP-NGVSESAPGAAVGGVSNMITNNI---------LGTTPFDSSEQPSQLTGA- 115
+N VP+SP N +A G A N I + TP ++S S G
Sbjct: 3 TNTVPSSPPNQTPPAASGIATSHDHTKFNNPIRLPISISLTINDTPNNNSNNNSVSNGLG 62
Query: 116 -LSAPVGDSALTGNHLPINLVLGQIEXXXXXXXXXXDIHHIPLTSPPIHGTIPQNGQALK 174
L + S + N+ N +G T+P ++ T K
Sbjct: 63 ILPSRTATSLVVANNGSANGNVGATAAAAATVETN--------TAPAVNTT--------K 106
Query: 175 NVHHFIYPAVRPASAP-SLHLDFAPDWAQPEAADDETVRNRKDKNGLFTLRLTAFIDNSS 233
++ HFIYP + SL + P+ + PE D T++ R DK+GLF++RLT FID SS
Sbjct: 107 SIRHFIYPPNQVNQTEFSLDIHLPPNTSLPERIDQSTLKRRMDKHGLFSIRLTPFIDTSS 166
Query: 234 AG--NPGFYFDPIIRTAGPGSQLVIGRYTEKVREAISSIPEPFHPAVFKSKVVSRTHGVF 291
N G +FDPIIRTAG GSQ++IGRYTE+VREAIS IP+ +HP VFKSKV+SRTHG F
Sbjct: 167 TSVANQGLFFDPIIRTAGAGSQIIIGRYTERVREAISKIPDQYHPVVFKSKVISRTHGCF 226
Query: 292 KVDDNGNWFVKDVKSSSGTFLNHQRLSQPATMSKDFLLKDGDILQLGLDFRGGAEEIYRC 351
KVDD GNWF+KDVKSSSGTFLNHQRLS +T SKD+LL DGDI+QLG+DFRGG EEIYRC
Sbjct: 227 KVDDQGNWFLKDVKSSSGTFLNHQRLSSASTTSKDYLLHDGDIIQLGMDFRGGTEEIYRC 286
Query: 352 VKMRVELNKSWRRKANAFNKEAIQKMKALQKMTSGTELEDCSICLSKIKACQAVFIAPCS 411
VKM++ELNKSW+ KANAFNKEA+ ++K LQK+T+G E EDCSICL+KIK CQA+FI+PC+
Sbjct: 287 VKMKIELNKSWKLKANAFNKEALSRIKNLQKLTTGLEQEDCSICLNKIKPCQAIFISPCA 346
Query: 412 HSWHFKCIRQLVSKTYPQFVCPNCRAVC 439
HSWHF C+R+LV YPQF+CPNCR C
Sbjct: 347 HSWHFHCVRRLVIMNYPQFMCPNCRTNC 374
>SPAC17G8.10c [T] KOG3872 FOG: FHA domain
Length = 267
Score = 173 bits (438), Expect = 6e-43
Identities = 95/220 (43%), Positives = 138/220 (62%), Gaps = 16/220 (7%)
Query: 222 TLRLTAFIDNSSAGNPGFYFDPIIRTAGPGSQ---LVIGRYTEKVREA-ISSIPEPFHPA 277
++RLT F+ ++ F FDP++R + IGRYTE+ +S+I
Sbjct: 28 SIRLTNFVGPNAHS---FSFDPLVRYWNRKQNNLPIYIGRYTERYNGGDVSAI------- 77
Query: 278 VFKSKVVSRTHGVFKVDDNGNWFVKDVKSSSGTFLNHQRLSQPATMSKDFLLKDGDILQL 337
VF+SKVVSR H ++N W+++D+ SSSGTFLNH RLS P+ SK + + + DILQL
Sbjct: 78 VFRSKVVSRRHAQIFYENN-TWYIQDMGSSSGTFLNHVRLSPPSKTSKPYPISNNDILQL 136
Query: 338 GLDFRGGAEEIYRCVKMRVELNKSWRRKANAFNKEAIQKMKALQKM-TSGTELEDCSICL 396
G D+RGG E YRCV+ RVELN SW+ K + +N ++M+ L +S + +C ICL
Sbjct: 137 GADYRGGHEVNYRCVRARVELNNSWKIKLSPYNLNEFKRMQELVLCGSSESGPPECCICL 196
Query: 397 SKIKACQAVFIAPCSHSWHFKCIRQLVSKTYPQFVCPNCR 436
+ CQA+F+APCSHS+H+KCIR +++++P F C CR
Sbjct: 197 MPVLPCQALFVAPCSHSYHYKCIRPTLNESHPYFSCFICR 236
>SPBC3H7.13 [T] KOG3872 FOG: FHA domain
Length = 301
Score = 59.7 bits (143), Expect = 1e-08
Identities = 40/110 (36%), Positives = 59/110 (53%), Gaps = 7/110 (6%)
Query: 250 PGSQLVIGRYTEKVREAISSIPEPFHPAVFKSKVVSRTHGVFKVD-DNGNWFVKDVKSSS 308
P + IGR+T K S+ P P + F SKV+SR H +D D + +++DVKSS+
Sbjct: 23 PSTIYKIGRHTNK-----STSPSPSN-LFFNSKVLSRQHAELWLDKDTLSVYIRDVKSSN 76
Query: 309 GTFLNHQRLSQPATMSKDFLLKDGDILQLGLDFRGGAEEIYRCVKMRVEL 358
GTF+N RLS S L GDI+ G+D E +++ V +V +
Sbjct: 77 GTFVNETRLSPENKPSAPCKLNSGDIVDFGVDIYNEDEIVHQKVSAQVRI 126
>7289492_1 [T] KOG3872 FOG: FHA domain
Length = 327
Score = 54.7 bits (130), Expect = 3e-07
Identities = 31/82 (37%), Positives = 48/82 (57%), Gaps = 8/82 (9%)
Query: 277 AVFKSKVVSRTHGVFKVDDNGNWFVKDVKSSSGTFLNHQRL-SQPATMSKDFLLKDGDIL 335
A+F KV+SR H + +G ++VKD KSS+GTF+N +L S PA L GDI+
Sbjct: 251 AIFDCKVLSRNHAILWYTPDGKFWVKDTKSSNGTFINDNKLGSDPAE------LHYGDIV 304
Query: 336 QLGLD-FRGGAEEIYRCVKMRV 356
+ G++ +E++ C+ RV
Sbjct: 305 KFGVEVIENSRQEVHGCILARV 326
>CE17187_1 [T] KOG3872 FOG: FHA domain
Length = 194
Score = 53.5 bits (127), Expect = 7e-07
Identities = 31/82 (37%), Positives = 51/82 (61%), Gaps = 5/82 (6%)
Query: 262 KVREAISSIPEPFHPAVFKSKVVSRTHGVFKVDDNGNWFVKDVKSSSGTFLNHQRLSQPA 321
K+ A++ I AVF KV+SR H + D G +++KD KSS+GTF+N+++L Q
Sbjct: 32 KIGRAVARIQATAENAVFDCKVLSRNHAILWFRD-GEFWLKDTKSSNGTFVNNEKLQQTV 90
Query: 322 TMSKDFLLK---DGDILQLGLD 340
+ +D ++ GDI+QLG++
Sbjct: 91 S-GRDTDVRRVFSGDIIQLGVE 111
>YLR238w [T] KOG3872 FOG: FHA domain
Length = 478
Score = 50.4 bits (119), Expect = 6e-06
Identities = 26/63 (41%), Positives = 39/63 (61%), Gaps = 6/63 (9%)
Query: 279 FKSKVVSRTHGVFKVDD-NGNWFVKDVKSSSGTFLNHQRLSQPATMSKDFLLKDGDILQL 337
F S+V+SR H + D G +++D+KSS+GTF+N QR+ S D +K GD++ L
Sbjct: 137 FDSRVLSRNHALLSCDPLTGKVYIRDLKSSNGTFINGQRIG-----SNDVEIKVGDVIDL 191
Query: 338 GLD 340
G D
Sbjct: 192 GTD 194
>Hs6005864 [O] KOG4628 Predicted E3 ubiquitin ligase
Length = 381
Score = 50.4 bits (119), Expect = 6e-06
Identities = 24/74 (32%), Positives = 42/74 (56%), Gaps = 3/74 (4%)
Query: 363 RRKANAFNKEAIQKMKALQKMTSGTELEDCSICLSKIKACQAVFIAPCSHSWHFKCIRQL 422
R + N K+ ++K+ + K G E + C+ICL + + + I PCSH++H KC+
Sbjct: 212 RARRNRLRKDQLKKLP-VHKFKKGDEYDVCAICLDEYEDGDKLRILPCSHAYHCKCVDPW 270
Query: 423 VSKTYPQFVCPNCR 436
++KT + CP C+
Sbjct: 271 LTKT--KKTCPVCK 282
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.316 0.134 0.402
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 30,960,051
Number of Sequences: 60738
Number of extensions: 1349949
Number of successful extensions: 3896
Number of sequences better than 1.0e-05: 8
Number of HSP's better than 0.0 without gapping: 3
Number of HSP's successfully gapped in prelim test: 5
Number of HSP's that attempted gapping in prelim test: 3885
Number of HSP's gapped (non-prelim): 9
length of query: 518
length of database: 30,389,216
effective HSP length: 111
effective length of query: 407
effective length of database: 23,647,298
effective search space: 9624450286
effective search space used: 9624450286
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)