ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactVI6481 check: MH L KOG0218 Replication, recombination and repair Mismatch repair MSH3
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactVI6481 2251454 2254273 940
(940 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
SPAC8F11.03 [L] KOG0218 Mismatch repair MSH3 228 4e-59
Hs4505249 [L] KOG0218 Mismatch repair MSH3 220 9e-57
SPCC285.16c [L] KOG0217 Mismatch repair ATPase MSH6 (MutS family) 211 6e-54
YOL090w [L] KOG0219 Mismatch repair ATPase MSH2 (MutS family) 201 3e-51
YCR092c [L] KOG0218 Mismatch repair MSH3 200 1e-50
At4g02070 [L] KOG0217 Mismatch repair ATPase MSH6 (MutS family) 198 3e-50
Hs4557761 [L] KOG0219 Mismatch repair ATPase MSH2 (MutS family) 194 7e-49
CE21000 [L] KOG0219 Mismatch repair ATPase MSH2 (MutS family) 186 2e-46
ECU10g0710 [L] KOG0217 Mismatch repair ATPase MSH6 (MutS family) 181 4e-45
YDR097c [L] KOG0217 Mismatch repair ATPase MSH6 (MutS family) 175 3e-43
CE28985 [L] KOG0217 Mismatch repair ATPase MSH6 (MutS family) 171 5e-42
7298155 [L] KOG0219 Mismatch repair ATPase MSH2 (MutS family) 169 1e-41
Hs4504191 [L] KOG0217 Mismatch repair ATPase MSH6 (MutS family) 166 1e-40
SPBC24C6.12c [L] KOG0219 Mismatch repair ATPase MSH2 (MutS family) 162 2e-39
ECU03g0540 [L] KOG0219 Mismatch repair ATPase MSH2 (MutS family) 154 8e-37
At4g25540 [L] KOG0218 Mismatch repair MSH3 149 2e-35
CE24714 [L] KOG0220 Mismatch repair ATPase MSH4 (MutS family) 143 1e-33
Hs4505251 [L] KOG0220 Mismatch repair ATPase MSH4 (MutS family) 141 4e-33
Hs20535615 [L] KOG0220 Mismatch repair ATPase MSH4 (MutS family) 141 4e-33
At4g17380 [L] KOG0220 Mismatch repair ATPase MSH4 (MutS family) 134 9e-31
Hs21361940 [L] KOG0221 Mismatch repair ATPase MSH5 (MutS family) 133 1e-30
Hs4505253 [L] KOG0221 Mismatch repair ATPase MSH5 (MutS family) 132 3e-30
At3g20475 [L] KOG0221 Mismatch repair ATPase MSH5 (MutS family) 125 4e-28
YDL154w [L] KOG0221 Mismatch repair ATPase MSH5 (MutS family) 124 9e-28
CE26678 [L] KOG0221 Mismatch repair ATPase MSH5 (MutS family) 120 1e-26
YFL003c [L] KOG0220 Mismatch repair ATPase MSH4 (MutS family) 107 9e-23
At3g24320 [L] KOG0217 Mismatch repair ATPase MSH6 (MutS family) 97 2e-19
At3g18525 [L] KOG0219 Mismatch repair ATPase MSH2 (MutS family) 60 1e-08
CE04858 [L] KOG0220 Mismatch repair ATPase MSH4 (MutS family) 51 1e-05
7294307 [L] KOG0217 Mismatch repair ATPase MSH6 (MutS family) 51 1e-05
>SPAC8F11.03 [L] KOG0218 Mismatch repair MSH3
Length = 1004
Score = 228 bits (580), Expect = 4e-59
Identities = 228/908 (25%), Positives = 400/908 (43%), Gaps = 93/908 (10%)
Query: 71 PSLQYVRDVMDKYTGHVVLTQIGSFYELYFEHATIYAPILNITLTSKSIVSGKVPFAGFP 130
P Q ++ Y ++ ++G + + + A I + +L I+ + A P
Sbjct: 105 PLEQQYLELKKNYQETILAIEVGYKFRFFGKDAKIASEVLGISCYFEHNFLN----ASVP 160
Query: 131 LNQLNRHLKVLVKQYGYSVAVCDQFKHETLVDNDKNK---FMRRVTRIVTPGTFIDEAFE 187
+++ HL+ L+ +G VAV Q + L ++ F RRV R++T GT +D++F
Sbjct: 161 SYRIDYHLERLIN-FGLKVAVVRQTETAALKSTSSSRNTLFDRRVARVLTKGTTLDDSFF 219
Query: 188 NFQE--------NQYLLTVHFSENCMK-RAADLNIPVGLSWCDISTG----EIFVQQVYL 234
F++ +Q++L V ++N K +A + VGL +S+G + F
Sbjct: 220 RFEQTQHGTLQASQFILCV--ADNVDKSKAKSGRVQVGLIAIQLSSGTTVYDHFQDDFLR 277
Query: 235 KDLVSSITRIRPMEVLLDEEIMP--VEITNGEWYKELTELKKYFIKYQKMPSKHRPIQSF 292
+L + ++ +P E++ ++ V + N E T + +++ +++
Sbjct: 278 SELQTRLSHFQPCELIYSNKLSSESVALLNHYVSTEKTCGRVVRVQHAVQQDVKLALENL 337
Query: 293 FKLFSNAEGDIGRSLGNFTQKEIAALRNLLLY---------IEEHLPDINTNLELPQKQL 343
FS+ G + +++ +L +L + +E L D+ Q
Sbjct: 338 QDFFSSKCIMSGSKIIELHMEKVKSLHSLSIICLDMAISYLMEFSLEDLFVASNFYQPFD 397
Query: 344 ITDIMQIDSRTSTALELHSTMRKHHKKGSLLSTIRRTVTTSGTRLLTQWLSAPSMDINEI 403
M + + LEL H GSL + RT T G R+L +WL P +D I
Sbjct: 398 SISSMVLSKQALEGLELFVNQTDHTPVGSLFWVLDRTYTRFGQRMLQRWLQKPLVDKENI 457
Query: 404 KNRQSLV--LLFKDNFDYTESLIRYLKETADMSRIIQRFSFGRGDPLELIQIAKSLRKCK 461
R V L F N +++ + L D+ + + R + R P E+ + K K
Sbjct: 458 IERLDAVEELAFNSN-SQVQAIRKMLYRLPDLEKGLSRIYYQRCTPSEMFHVLKGFYKA- 515
Query: 462 EISEYLQTNVHPSTKKTEKLIKNITKQLNFEDPIVEKVISSLNEESLIKQWSEKYER-DD 520
+ N + K L++ + +QL I++ + +++ + + K + D
Sbjct: 516 --ASAFSKNSYSCFKSA--LLRRLIQQLPSISSIIDHFLGMFDQKEA--ENNNKVDMFKD 569
Query: 521 EEKFDASEENQERKSLVMIMKPSASQKLKEYYKSYNILIKEKESLLQWYKDWFLERFKLK 580
+ FD SEE + + +Q+++E S ++ E + LQ +D+ +
Sbjct: 570 IDNFDLSEEPND-------VDYELAQEIRELKMSILMVRTEMDFHLQELRDYL----EYP 618
Query: 581 NVSLKQKNSGEFCIHLSGSIANVVEFDKYIEQQKDSSQAHSGFHVLQKSRQTRWIIHDKW 640
N+ + +FCI +S K + + L +R K
Sbjct: 619 NLEFSIWGNVKFCIEVS----------------KGCKKIPPDWIKLSSTRSLFRFHTPKI 662
Query: 641 ETLSREIEVVGALIKNEEERLINQFQKDFISLSPMIRSLSQTLDYMDVLTSFAKLAIEQR 700
++L E+ + E++ F +R+++ L +D L SFA+++ +
Sbjct: 663 QSLLIELSSHEENLTISSEKIYRSFLSRISEHYNELRNVTTVLGTLDCLISFARISSQSG 722
Query: 701 LVLPKVTQGTELNIKGGRHLVVEASISQKSLESFTPNDCQINSGEL--WVITGPNMGGKS 758
P+ + EL I RH ++E +S KS F PN ++S + +ITGPNMGGKS
Sbjct: 723 YTRPEFSD-KELLIHESRHPMIEL-LSDKS---FVPNHIHLSSDGVRCLLITGPNMGGKS 777
Query: 759 TFLRQNAIIVILAQIGSFVPCESAVIGLVDKIFSRVGSADDLYNEMSTFMVEMIETSYIL 818
+F++Q A+ I+AQ G FVP +SA++ + D I R+GS+D+L MSTFMVEM+ET +L
Sbjct: 778 SFVKQLALSAIMAQSGCFVPAKSALLPIFDSILIRMGSSDNLSVNMSTFMVEMLETKEVL 837
Query: 819 KGATNRSMAILDEIGRGTSRSEGVAIAYATLKYLTTNNACRALFATHFGTELASTINSTS 878
AT +SM I+DE+GRGTS +G AI+YA L YL LF THF +
Sbjct: 838 SKATEKSMVIIDELGRGTSTIDGEAISYAVLHYLNQYIKSYLLFVTHFPS------LGIL 891
Query: 879 NEEFINNISFFKTGIIGDNSNF--------YYDHKLKPGICSKSDAIKVAKLAGFPEEAL 930
F + F G + +F + +KL PG+ SKS + VA++AG P L
Sbjct: 892 ERRFEGQLRCFHMGYLKSKEDFETSVSQSISFLYKLVPGVASKSYGLNVARMAGIPFSIL 951
Query: 931 EIASTLLE 938
A+ + E
Sbjct: 952 SRATEISE 959
>Hs4505249 [L] KOG0218 Mismatch repair MSH3
Length = 1128
Score = 220 bits (560), Expect = 9e-57
Identities = 236/944 (25%), Positives = 422/944 (44%), Gaps = 122/944 (12%)
Query: 54 RTKSSDRGGRETRNSLPPSLQYVRDVMDKYTGHVVLTQIGSFYELYFEHATIYAPILNIT 113
+T S R P LQY+ ++ ++ V+ + G Y + E A I A LNI
Sbjct: 206 KTASKSANKRSKSIYTPLELQYI-EMKQQHKDAVLCVECGYKYRFFGEDAEIAARELNIY 264
Query: 114 LTSKSIVSGKVPFAGFPLNQLNRHLKVLVKQYGYSVAVCDQFKHETLV---DNDKNKFMR 170
+ A P ++L H++ LV + GY V V Q + L DN + F R
Sbjct: 265 CH----LDHNFMTASIPTHRLFVHVRRLVAK-GYKVGVVKQTETAALKAIGDNRSSLFSR 319
Query: 171 RVTRIVTPGTFIDEAFE---------NFQE------NQYLLTVHFSENCMKRAADLNIPV 215
++T + T T I E N E YLL + ++ ++ NI +
Sbjct: 320 KLTALYTKSTLIGEDVNPLIKLDDAVNVDEIMTDTSTSYLLCISENKENVRDKKKGNIFI 379
Query: 216 GLSWCDISTGEI----FVQQVYLKDLVSSITRIRPMEVLLDEEIMPVEITNGEWYKELT- 270
G+ +TGE+ F +L + ++ ++P+E+LL + E T ++ +
Sbjct: 380 GIVGVQPATGEVVFDSFQDSASRSELETRMSSLQPVELLLPSALS--EQTEALIHRATSV 437
Query: 271 ELKKYFIKYQKMPSKH----RPIQSFFKLFSNAEGDIGRS-----LGNFTQKEIAALRNL 321
++ I+ ++M + + Q+ + ++ DI S + N + I +L +
Sbjct: 438 SVQDDRIRVERMDNIYFEYSHAFQAVTEFYAKDTVDIKGSQIISGIVNLEKPVICSLAAI 497
Query: 322 LLYIEEHLPDINTNLELPQ--KQLIT--DIMQIDSRTSTALELHSTMRKHHKKGSLLSTI 377
+ Y++E ++ L P+ KQL + + M I+ T LE+ KGSLL +
Sbjct: 498 IKYLKEF--NLEKMLSKPENFKQLSSKMEFMTINGTTLRNLEILQNQTDMKTKGSLLWVL 555
Query: 378 RRTVTTSGTRLLTQWLSAPSMDINEIKNRQSLV--LLFKDNFDYTESLIRYLKETADMSR 435
T T+ G R L +W++ P + + EI R V +L ++ + + + +L++ D+ R
Sbjct: 556 DHTKTSFGRRKLKKWVTQPLLKLREINARLDAVSEVLHSESSVFGQ-IENHLRKLPDIER 614
Query: 436 IIQRFSFGRGDPLELIQIAKSLRKCKEISEYL--QTNVHPSTKKTEKLIKNITKQLNFED 493
+ + E I K+L K + + N H + +I I + L+
Sbjct: 615 GLCSIYHKKCSTQEFFLIVKTLYHLKSEFQAIIPAVNSHIQSDLLRTVILEIPELLS--- 671
Query: 494 PIVEKVISSLNEESLIKQWSEKYERDDEEKFDASEENQERKSLVMIMKPSASQKLKEYYK 553
VE + LNE++ + D +E ++ +I K +++
Sbjct: 672 -PVEHYLKILNEQAA-------------KVGDKTELFKDLSDFPLIKK--RKDEIQGVID 715
Query: 554 SYNILIKEKESLLQWYKDWFLERFKLKNVSLKQKNSGEFCIHLSGSIANVVEFDKY-IEQ 612
+ ++E +L K + + EF I + S + + D +
Sbjct: 716 EIRMHLQEIRKIL-----------KNPSAQYVTVSGQEFMIEIKNSAVSCIPTDWVKVGS 764
Query: 613 QKDSSQAHSGFHVLQKSRQTRWIIHDKWETLSREIEVVGALIKNEEERLINQFQKDFISL 672
K S+ HS F V + + L++ E + E + +F + + SL
Sbjct: 765 TKAVSRFHSPFIV------------ENYRHLNQLREQLVLDCSAEWLDFLEKFSEHYHSL 812
Query: 673 SPMIRSLSQTLDYMDVLTSFAKLAIEQRLVLPKVTQGTELNIKGGRHLVVEASISQKSLE 732
+ L+ +D + S AK+A + P V + ++ IK GRH V++ + ++ +
Sbjct: 813 CKAVHHLAT----VDCIFSLAKVAKQGDYCRPTVQEERKIVIKNGRHPVIDVLLGEQ--D 866
Query: 733 SFTPNDCQIN--SGELWVITGPNMGGKSTFLRQNAIIVILAQIGSFVPCESAVIGLVDKI 790
+ PN+ ++ S + +ITGPNMGGKS++++Q A+I I+AQIGS+VP E A IG+VD I
Sbjct: 867 QYVPNNTDLSEDSERVMIITGPNMGGKSSYIKQVALITIMAQIGSYVPAEEATIGIVDGI 926
Query: 791 FSRVGSADDLYNEMSTFMVEMIETSYILKGATNRSMAILDEIGRGTSRSEGVAIAYATLK 850
F+R+G+AD++Y STFM E+ +T+ I++ AT++S+ ILDE+GRGTS +G+AIAYATL+
Sbjct: 927 FTRMGAADNIYKGRSTFMEELTDTAEIIRKATSQSLVILDELGRGTSTHDGIAIAYATLE 986
Query: 851 YLTTNNACRALFATHFGTELASTINSTSNEEFINNISFFKTGIIGDNSNFYYD------- 903
Y + LF TH+ N + + + + G + D
Sbjct: 987 YFIRDVKSLTLFVTHYPPVCELEKN------YSHQVGNYHMGFLVSEDESKLDPGAAEQV 1040
Query: 904 -------HKLKPGICSKSDAIKVAKLAGFPEEALEIASTLLEEI 940
+++ GI ++S + VAKLA P E L+ A+ +E+
Sbjct: 1041 PDFVTFLYQITRGIAARSYGLNVAKLADVPGEILKKAAHKSKEL 1084
>SPCC285.16c [L] KOG0217 Mismatch repair ATPase MSH6 (MutS family)
Length = 1254
Score = 211 bits (536), Expect = 6e-54
Identities = 221/907 (24%), Positives = 387/907 (42%), Gaps = 127/907 (14%)
Query: 77 RDVMDKYTGHVVLTQIGSFYELYFEHATIYAPILNITLTSKSIVSGKVPFAGFPLNQLNR 136
+D+MD VV Q G FYELY A I + ++ LT + + G P +
Sbjct: 386 KDLMDT----VVFFQKGKFYELYENDAAIGHQVFSLKLTDRV----NMKMVGIPEASFDY 437
Query: 137 HLKVLVKQYGYSVAVCDQF--------KHETLVDNDKNKFMRRVTRIVTPGTFIDEAFEN 188
+ + GY +A DQ K ++ R +T+++T GT +DEA
Sbjct: 438 WASQFIAK-GYRIARVDQLETALGKEIKDRQRTQKEEKVVQRGLTQVLTSGTLVDEA--- 493
Query: 189 FQENQYLLTVHFSENCMKRAADLNIP-----VGLSWCDISTGEI----FVQQVYLKDLVS 239
+LT S CM L G+ + D STG F ++ L +
Sbjct: 494 ------MLTSDLSTYCMAIKESLQSDNEEPSFGICFIDTSTGGFHMCEFTDDIHRTKLDT 547
Query: 240 SITRIRPMEVLLDE-EIMPVEITNGEWYKELTELKKYFIKYQKMPSKHRPIQSFFK--LF 296
+T++RP E++L++ +I I ++ + + + Y + R + F
Sbjct: 548 LLTQVRPKELILEKSKISQKSIRAIKYCVSSSSIWNFIKPYTEFWDNERVEREIIAGDYF 607
Query: 297 SNAEGDIGRSLGNFTQKE---IAALRNLLLYI-----EEHLPDINTNLELPQKQLITDIM 348
N + L ++ ++ I+A L Y+ ++ + + E Q T ++
Sbjct: 608 KNGLEGAPKILKSYLSEKPLAISAFGALFWYLRQLKLDKDMCSMGNFDEYDASQQSTSLL 667
Query: 349 QIDSRTSTALELHSTMRKHHKKGSLLSTIRRTVTTSGTRLLTQWLSAPSMDINEIKNRQS 408
++ +T LE+ S +G+L + R VT G RL WL P I R
Sbjct: 668 -MNGQTLKNLEIFSNSFDGGSEGTLFHLLCRCVTPFGKRLFHTWLCHPLRSGTAINARLD 726
Query: 409 LVLLFKDNFDYTESLIRYLKETADMSRIIQRFSFGRGDPLELIQIAKSLRKCKEISEYLQ 468
+V L DN +++ +L + D+ R+I R GR P + +++ + ++ + L+
Sbjct: 727 VVELIADNPVIRDTIWGFLHKLPDLERLISRVHAGRSKPADFVRVLEGFQRINSAFDQLR 786
Query: 469 TNVHPSTKKTEKLIKNITKQLNFEDPIVEKVISSLNEESLIKQWSEKYERDDEEKFDASE 528
+ T + E + S+ N + ++ W+ + ASE
Sbjct: 787 EEFMEVAEGTL---------------LGEIIQSAPNMKEELEAWTRAFNWQK-----ASE 826
Query: 529 ENQERKSLVMIMKPSASQKLKEYYKSYNILIKEKESLLQWYKDWFLERFKLKNVSLKQKN 588
E + + SQK + K+ E +LL+ YK +L+ SL KN
Sbjct: 827 EGVFEPEIGFEAEYDTSQKYQSELKN------ELYALLEQYKK------QLRCSSLNFKN 874
Query: 589 SGE--FCIHLSGSIANVVEFDKYIEQQKDSSQAHSGFHVLQKSRQTRWIIHDKWETLSRE 646
G+ + + + + V + K +K + + + K + L
Sbjct: 875 IGKEVYQVEVPSDVKVPVNWCKMSGTKKTNRYYNDE-------------LRKKIKKLLEA 921
Query: 647 IEVVGALIKNEEERLINQFQKDFISLSPMIRSLSQTLDYMDVLTSFAKLAIEQRLVLPKV 706
E+ A++ +E+ +F ++ +I+ + + + S A A+ + P++
Sbjct: 922 EELHLAIMSRMQEKFYIRFDSNYEQWLALIKYTASIDCFFSL--SQAAAALGEPYCRPEI 979
Query: 707 TQGTE--LNIKGGRHLVVEASISQKSLESFTPNDCQIN--SGELWVITGPNMGGKSTFLR 762
+ + L + RH + AS + +F PND + S + V+TGPNM GKST LR
Sbjct: 980 IEQKDGHLYFEELRHPCINASAAS----TFVPNDVVLGGESPNMIVLTGPNMAGKSTLLR 1035
Query: 763 QNAIIVILAQIGSFVPCESAVIGLVDKIFSRVGSADDLYNEMSTFMVEMIETSYILKGAT 822
Q I VI+AQ+G +VP + A I + I++R+G+ DD+ + STFMVE+ ET IL
Sbjct: 1036 QVCIAVIMAQLGCWVPAKRASITPMTSIYTRLGANDDIMSARSTFMVELSETKKILDECG 1095
Query: 823 NRSMAILDEIGRGTSRSEGVAIAYATLKYLTTNNACRALFATHFGTELASTIN------- 875
+S+ ILDE+GRGTS +G AIAYA L +L +N C F+TH+ + ++
Sbjct: 1096 PKSLVILDELGRGTSTYDGHAIAYAVLHHLVSNIGCLGFFSTHYQSLCVDFMHHRQVRLM 1155
Query: 876 --STSNEEFINNISFFKTGIIGDNSNFYYDHKLKPGICSKSDAIKVAKLAGFPEEALEIA 933
+ + +E I ++F +KL+ GIC KS + VA +AG PE+ ++ A
Sbjct: 1156 QMAAAVDEKIRRVTFL--------------YKLEDGICPKSYGMNVASMAGLPEKVIDAA 1201
Query: 934 STLLEEI 940
E+
Sbjct: 1202 EEKASEL 1208
>YOL090w [L] KOG0219 Mismatch repair ATPase MSH2 (MutS family)
Length = 964
Score = 201 bits (512), Expect = 3e-51
Identities = 165/586 (28%), Positives = 289/586 (49%), Gaps = 54/586 (9%)
Query: 369 KKGSLLSTIRRTVTTSGTRLLTQWLSAPSMDINEIKNRQSLVLLFKDNFDYTESLI-RYL 427
K SL + T +G RLL +WL P +I+EI R LV D + + L YL
Sbjct: 334 KVTSLFQLLNHCKTNAGVRLLNEWLKQPLTNIDEINKRHDLVDYLIDQIELRQMLTSEYL 393
Query: 428 KETADMSRIIQRFSFGRGDPLELIQIAKSLRKCKEISEYLQTNVHPS--TKKTEKLIKNI 485
D+ R+ ++ + RG+ ++++I + ++ EI + + + T+ +L++++
Sbjct: 394 PMIPDIRRLTKKLN-KRGNLEDVLKIYQFSKRIPEIVQVFTSFLEDDSPTEPVNELVRSV 452
Query: 486 TKQLNFEDPIVEKVISSLNEESLIKQWSEKYERDDEEKFDASEENQERKSLVMIMKPSAS 545
+ P+ V E +++ + DA EEN E ++K +
Sbjct: 453 -----WLAPLSHHVEPLSKFEEMVETTVD---------LDAYEENNE-----FMIKVEFN 493
Query: 546 QKLKEYYKSYNILIKEKESL-LQWYKDWFLERFKLKNVSLKQKNSGEFCIHLSGSIANVV 604
++L + + L E S+ L +D + K + L+ + +C+ L+ + A +
Sbjct: 494 EELGKIRSKLDTLRDEIHSIHLDSAEDLGFDPDK--KLKLENHHLHGWCMRLTRNDAKEL 551
Query: 605 -EFDKYIEQQKDSSQAHSGFHVLQKSRQTRWIIHDKWETLSREIEVVGALIKNEEERLIN 663
+ KYIE S +G K + ++++ E ++ ++ L+
Sbjct: 552 RKHKKYIEL----STVKAGIFFSTK----------QLKSIANETNILQKEYDKQQSALVR 597
Query: 664 QFQKDFISLSPMIRSLSQTLDYMDVLTSFAKLAIEQRL--VLPKV---TQGTELNIKGGR 718
+ ++ +P+ LS L ++DV+ SFA + + + PK+ ++ R
Sbjct: 598 EIINITLTYTPVFEKLSLVLAHLDVIASFAHTSSYAPIPYIRPKLHPMDSERRTHLISSR 657
Query: 719 HLVVEASISQKSLESFTPNDCQINSG--ELWVITGPNMGGKSTFLRQNAIIVILAQIGSF 776
H V+E Q + SF ND + SG + +ITGPNMGGKST++RQ +I ++AQIG F
Sbjct: 658 HPVLEM---QDDI-SFISNDVTLESGKGDFLIITGPNMGGKSTYIRQVGVISLMAQIGCF 713
Query: 777 VPCESAVIGLVDKIFSRVGSADDLYNEMSTFMVEMIETSYILKGATNRSMAILDEIGRGT 836
VPCE A I +VD I RVG+ D +STFMVE++ET+ ILK A+ S+ I+DE+GRGT
Sbjct: 714 VPCEEAEIAIVDAILCRVGAGDSQLKGVSTFMVEILETASILKNASKNSLIIVDELGRGT 773
Query: 837 SRSEGVAIAYATLKYLTTNNACRALFATHFG--TELASTINSTSNEEFINNISFFKTGII 894
S +G +A+A +++ + C ALFATHF TEL+ + + N + +I
Sbjct: 774 STYDGFGLAWAIAEHIASKIGCFALFATHFHELTELSEKLPNVKNMHVVAHIEKNLKEQK 833
Query: 895 GDNSNFYYDHKLKPGICSKSDAIKVAKLAGFPEEALEIASTLLEEI 940
D+ + +K++PGI +S I VA++ FPE+ +++A E+
Sbjct: 834 HDDEDITLLYKVEPGISDQSFGIHVAEVVQFPEKIVKMAKRKANEL 879
>YCR092c [L] KOG0218 Mismatch repair MSH3
Length = 1047
Score = 200 bits (508), Expect = 1e-50
Identities = 225/919 (24%), Positives = 403/919 (43%), Gaps = 119/919 (12%)
Query: 69 LPPSLQYVRDVMDKYTGHVVLTQIGSFYELYFEHATIYAPILNITLT-SKSIVSGKVP-- 125
L P + V+D+ + V++ ++G Y+ + E A + IL+I L K + P
Sbjct: 161 LTPLDKQVKDLKMHHRDKVLVIRVGYKYKCFAEDAVTVSRILHIKLVPGKLTIDESNPQD 220
Query: 126 -------FAGFPLNQLNRHLKVLVKQYGYSVAVCDQFKHETLVDND-----KNKFMRRVT 173
+ FP +LN HL+ LV + VAV +Q + + +D + F R+++
Sbjct: 221 CNHRQFAYCSFPDVRLNVHLERLV-HHNLKVAVVEQAETSAIKKHDPGASKSSVFERKIS 279
Query: 174 RIVTPGTF-IDEAF-----ENFQENQYLLTVHFSENCMKRAADLNIPVGLSWCDISTGEI 227
+ T TF ++ F + + + + K A I V L+ ++ E
Sbjct: 280 NVFTKATFGVNSTFVLRGKRILGDTNSIWALSRDVHQGKVAKYSLISVNLNNGEVVYDEF 339
Query: 228 FVQQVYLKDLVSSITRIRPMEVLLDEEIMPVEITNGEWYKELTELKKYFIKYQKMPSKHR 287
+ + L I ++P+EVL++ + +P+ + K ++ I Q+ +
Sbjct: 340 EEPNLADEKLQIRIKYLQPIEVLVNTDDLPLHVA-----KFFKDISCPLIHKQEYDLEDH 394
Query: 288 PIQSFFKLFSNAEGDIGRSLGNFTQKEIAALRNLLLYIEEHLPDINTNLELPQKQLITDI 347
+Q+ + N + + SL K + H+ + N Q LI I
Sbjct: 395 VVQAIKVM--NEKIQLSPSLIRLVSK-----------LYSHMVEYNNE----QVMLIPSI 437
Query: 348 ---------MQIDSRTSTALELHSTMRKHHKKGSLLSTIRRTVTTSGTRLLTQWLSAPSM 398
M +D + +L++ + KGSL + T T+ G R+L +W+ P +
Sbjct: 438 YSPFASKIHMLLDPNSLQSLDIFT---HDGGKGSLFWLLDHTRTSFGLRMLREWILKPLV 494
Query: 399 DINEIKNRQSLVLLFK---DNFDYTESLIRYLKETADMSRIIQRFSFGRGDPLE----LI 451
D+++I+ R + +N + ESL + L T D+ R + R +G E L
Sbjct: 495 DVHQIEERLDAIECITSEINNSIFFESLNQMLNHTPDLLRTLNRIMYGTTSRKEVYFYLK 554
Query: 452 QIAKSLRKCKEISEYLQTNVHPSTKKTEKLIKNITKQLNFEDPIVEKVISSLNEESLIKQ 511
QI + K YL + S + K + P++ ++ S LNE L+
Sbjct: 555 QITSFVDHFKMHQSYLSEHFKSSDGRIGK-----------QSPLLFRLFSELNE--LLST 601
Query: 512 WSEKYERDDEEKFDASEENQERKSLVMIMKPSASQKLKEYYKSYNI--LIKEKESLLQWY 569
+ E+N +++ + L Y S I + +E ES+
Sbjct: 602 TQLPHFLTMINVSAVMEKNSDKQVMDFF-------NLNNYDCSEGIIKIQRESESVRSQL 654
Query: 570 KDWFLE-RFKLKNVSLKQKNSGEFCIHLSGSIANVVEFDKYIEQQKDSSQAHSGFHVLQK 628
K+ E R LK L ++ ++ I + S Q KD + +
Sbjct: 655 KEELAEIRKYLKRPYLNFRDEVDYLIEVKNS------------QIKD---LPDDWIKVNN 699
Query: 629 SRQTRWIIHDKWETLSREIEVVGALIKNEEERLINQFQKDFISLSPMIRSLSQTLDYMDV 688
++ + + L++++E L+ E E +F + +R ++ L D
Sbjct: 700 TKMVSRFTTPRTQKLTQKLEYYKDLLIRESELQYKEFLNKITAEYTELRKITLNLAQYDC 759
Query: 689 LTSFAKLAIEQRLVLPKVTQGTELNI-KGGRHLVVEASISQKSLE-SFTPNDCQIN--SG 744
+ S A + V P G + I K R+ ++E SL+ + PND ++ +G
Sbjct: 760 ILSLAATSCNVNYVRPTFVNGQQAIIAKNARNPIIE------SLDVHYVPNDIMMSPENG 813
Query: 745 ELWVITGPNMGGKSTFLRQNAIIVILAQIGSFVPCESAVIGLVDKIFSRVGSADDLYNEM 804
++ +ITGPNMGGKS+++RQ A++ I+AQIGSFVP E + + + + +R+G+ DD+ N
Sbjct: 814 KINIITGPNMGGKSSYIRQVALLTIMAQIGSFVPAEEIRLSIFENVLTRIGAHDDIINGD 873
Query: 805 STFMVEMIETSYILKGATNRSMAILDEIGRGTSRSEGVAIAYATLKYLTTNNAC-RALFA 863
STF VEM++ +ILK RS+ +LDE+GRGT +G+AI+YA +KY + + C LF
Sbjct: 874 STFKVEMLDILHILKNCNKRSLLLLDEVGRGTGTHDGIAISYALIKYFSELSDCPLILFT 933
Query: 864 THFGT--ELASTINSTSNEEFINNISFFKTGIIGDNSNFYYDHKLKPGICSKSDAIKVAK 921
THF E+ S + + +++ KTG D + + +KLK G+ S + VAK
Sbjct: 934 THFPMLGEIKSPLIRNYHMDYVEE---QKTG--EDWMSVIFLYKLKKGLTYNSYGMNVAK 988
Query: 922 LAGFPEEALEIASTLLEEI 940
LA ++ + A ++ EE+
Sbjct: 989 LARLDKDIINRAFSISEEL 1007
>At4g02070 [L] KOG0217 Mismatch repair ATPase MSH6 (MutS family)
Length = 1324
Score = 198 bits (504), Expect = 3e-50
Identities = 246/1031 (23%), Positives = 435/1031 (41%), Gaps = 159/1031 (15%)
Query: 3 RRSTALLIPYFRSSFLRRSSTV-QTPKTEK-LKISLLNDDTLIETESLPTSAIRTKSSDR 60
+ T ++ F++S + + + Q + K L+ ++L+ D L + + R DR
Sbjct: 292 KTDTGTILKGFKASVVEPAKKIGQADRVVKGLEDNVLDGDALARFGARDSEKFRFLGVDR 351
Query: 61 GGRETR-----NSLPPSLQYVRDVMDKYTG--------------HVVLTQIGSFYELYFE 101
+ R N P +L D + K TG VV ++G FYEL+
Sbjct: 352 RDAKRRRPTDENYDPRTLYLPPDFVKKLTGGQRQWWEFKAKHMDKVVFFKMGKFYELFEM 411
Query: 102 HATIYAPILNITLTSKSIVSGKVPFAGFPLNQLNRHLKVLVKQYGYSVAVC------DQF 155
A + A L+I + G+ P GFP + +++ LV++ GY V V DQ
Sbjct: 412 DAHVGAKELDI-----QYMKGEQPHCGFPEKNFSVNIEKLVRK-GYRVLVVEQTETPDQL 465
Query: 156 KHETLVDNDKNKFMRR-VTRIVTPGTFID-EAFENFQENQYLLTV-HFSENCMKRAADLN 212
+ K+K ++R V +VT GT D E + YL+ + E+ A+ N
Sbjct: 466 EQRRKETGSKDKVVKREVCAVVTKGTLTDGEMLLTNPDASYLMALTEGGESLTNPTAEHN 525
Query: 213 IPVGLSWCDISTGEIFVQQVYLKD------LVSSITRIRPMEVLLDEEIMP-------VE 259
G+ D++T +I + Q KD L ++ +RP+E++ +++ V
Sbjct: 526 F--GVCLVDVATQKIILGQ--FKDDQDCSALSCLLSEMRPVEIIKPAKVLSYATERTIVR 581
Query: 260 ITNGEWYKELTELKKYF----------IKYQKMPSK-HRPIQSFFKLFSNAEGDIGRSLG 308
T L L +++ I Y+++ + S K+ + + + L
Sbjct: 582 QTRNPLVNNLVPLSEFWDSEKTIYEVGIIYKRINCQPSSAYSSEGKILGDGSSFLPKMLS 641
Query: 309 NFTQKE------IAALRNLLLYIE--------------EHLPDINTNLELPQKQLITDIM 348
++ ++AL + Y+ E LP + + ++ ++ D
Sbjct: 642 ELATEDKNGSLALSALGGAIYYLRQAFLDESLLRFAKFESLPYCDFSNVNEKQHMVLDAA 701
Query: 349 QIDSRTSTALELHSTMRKHHKKGSLLSTIRRTVTTSGTRLLTQWLSAPSMDINEIKNRQS 408
+++ LE+ R G+L + + + +T SG RLL WL+ P + IK RQ
Sbjct: 702 ALEN-----LEIFENSRNGGYSGTLYAQLNQCITASGKRLLKTWLARPLYNTELIKERQD 756
Query: 409 LVLLFK-DNFDYTESLIRYLKETADMSRIIQRF------SFGRGDPLELIQIAKSLRKCK 461
V + + +N Y+ + L DM R+I R S GD + L + K
Sbjct: 757 AVAILRGENLPYSLEFRKSLSRLPDMERLIARMFSSIEASGRNGDKVVLYEDTAK----K 812
Query: 462 EISEYLQT-----NVHPSTKKTEKLIKNITKQ--LNFEDP--IVEKVISSLNEESLIKQW 512
++ E++ T + + ++K+ T + L+ P + + SS+ W
Sbjct: 813 QVQEFISTLRGCETMAEACSSLRAILKHDTSRRLLHLLTPGQSLPNISSSIKYFKDAFDW 872
Query: 513 SEKYERDDEEKFDASEENQERKSLVMIMKPSASQKLKEYYKSYNILIKEKESLLQWYKDW 572
E + + ++E + A + ++E+ S +KE+ LL
Sbjct: 873 VEAHNSGRVIPHEGADEEYD----------CACKTVEEFESSLKKHLKEQRKLLGD---- 918
Query: 573 FLERFKLKNVSLKQKNSGEFCIHLSGSIANVVEFDKYIEQQKDSSQAHSGFHVLQKSRQT 632
+++ E+ + + S++ V D + K SR
Sbjct: 919 -------ASINYVTVGKDEYLLEVPESLSGSVPHDYELCSSKKGV-----------SRYW 960
Query: 633 RWIIHDKWETLSREIEVVGALIKNEEERLINQFQKDFISLSPMIRSLSQTLDYMDVLTS- 691
I + LS+ + +K+ +RLI +F + ++ + ++ +DVL S
Sbjct: 961 TPTIKKLLKELSQAKSEKESALKSISQRLIGRFCEHQEKWRQLVSATAE----LDVLISL 1016
Query: 692 -FAKLAIEQRLVLPKVTQGTE-----LNIKGGRHLVVEASISQKSLESFTPNDCQINSGE 745
FA + E P ++ T L+ G H V+ + SF PN+ +I E
Sbjct: 1017 AFASDSYEGVRCRPVISGSTSDGVPHLSATGLGHPVLRGDSLGRG--SFVPNNVKIGGAE 1074
Query: 746 ---LWVITGPNMGGKSTFLRQNAIIVILAQIGSFVPCESAVIGLVDKIFSRVGSADDLYN 802
++TGPNMGGKST LRQ + VILAQIG+ VP E+ + VDKI R+G+ D +
Sbjct: 1075 KASFILLTGPNMGGKSTLLRQVCLAVILAQIGADVPAETFEVSPVDKICVRMGAKDHIMA 1134
Query: 803 EMSTFMVEMIETSYILKGATNRSMAILDEIGRGTSRSEGVAIAYATLKYLTTNNACRALF 862
STF+ E+ ET+ +L AT S+ +LDE+GRGT+ S+G AIA + L++ CR F
Sbjct: 1135 GQSTFLTELSETAVMLTSATRNSLVVLDELGRGTATSDGQAIAESVLEHFIEKVQCRGFF 1194
Query: 863 ATHFGTELASTINSTSNEEFINNISFFKTGIIGDNSNFYYDHKLKPGICSKSDAIKVAKL 922
+TH+ S T+ + + +++ IG + ++L PG C KS + VA+L
Sbjct: 1195 STHY--HRLSVDYQTNPKVSLCHMACQIGEGIGGVEEVTFLYRLTPGACPKSYGVNVARL 1252
Query: 923 AGFPEEALEIA 933
AG P+ L+ A
Sbjct: 1253 AGLPDYVLQRA 1263
>Hs4557761 [L] KOG0219 Mismatch repair ATPase MSH2 (MutS family)
Length = 934
Score = 194 bits (492), Expect = 7e-49
Identities = 169/603 (28%), Positives = 289/603 (47%), Gaps = 75/603 (12%)
Query: 348 MQIDSRTSTALEL-HSTMRKHHKKGSLLSTIRRTVTTSGTRLLTQWLSAPSMDINEIKNR 406
M++D AL L ++ SL + + + T G RL+ QW+ P MD N I+ R
Sbjct: 300 MKLDIAAVRALNLFQGSVEDTTGSQSLAALLNKCKTPQGQRLVNQWIKQPLMDKNRIEER 359
Query: 407 QSLVLLFKDNFDYTESLIR-YLKETADMSRIIQRFSFGRGDPLELIQIAKSLRKCKEISE 465
+LV F ++ + ++L L+ D++R+ ++F + + ++ + + + + +
Sbjct: 360 LNLVEAFVEDAELRQTLQEDLLRRFPDLNRLAKKFQRQAANLQDCYRLYQGINQLPNVIQ 419
Query: 466 YLQTNVHPSTKKTEKLIKNITKQLNFEDPIVEKVISSLNEESLIKQWSEKYERDDEEKFD 525
L+ + K +KL+ + F P+ + ++ K++ E D
Sbjct: 420 ALEKH----EGKHQKLLLAV-----FVTPLTD-----------LRSDFSKFQEMIETTLD 459
Query: 526 ASE-ENQERKSLVMIMKPSASQKLKEYYKSYNILIKEKES-LLQWYKDWFLERFKLKNVS 583
+ EN E ++KPS L E + N L K+ +S L+ +D L+ K
Sbjct: 460 MDQVENHE-----FLVKPSFDPNLSELREIMNDLEKKMQSTLISAARDLGLDPGK----Q 510
Query: 584 LKQKNSGEFCIHLSGSIANVVEFDKYIEQQKDSSQAHSGFHVLQKSRQTRWIIHDKWETL 643
+K +S +F + + +K + K+ S +QK+ + K +L
Sbjct: 511 IKLDSSAQFGYYFRVTCKE----EKVLRNNKNFSTVD-----IQKNGVK--FTNSKLTSL 559
Query: 644 SREIEVVGALIKNEEERLINQFQKDFISLS-----PMIRSLSQTLDYMDVLTSFAKLAIE 698
+ E K E E + K+ +++S PM ++L+ L +D + SFA ++
Sbjct: 560 NEEY----TKNKTEYEEAQDAIVKEIVNISSGYVEPM-QTLNDVLAQLDAVVSFAHVSNG 614
Query: 699 QRL--VLPKVTQGTE--LNIKGGRHLVVEASISQKSLESFTPNDCQINSGE--LWVITGP 752
+ V P + + + + +K RH VE + +F PND + +ITGP
Sbjct: 615 APVPYVRPAILEKGQGRIILKASRHACVEV----QDEIAFIPNDVYFEKDKQMFHIITGP 670
Query: 753 NMGGKSTFLRQNAIIVILAQIGSFVPCESAVIGLVDKIFSRVGSADDLYNEMSTFMVEMI 812
NMGGKST++RQ +IV++AQIG FVPCESA + +VD I +RVG+ D +STFM EM+
Sbjct: 671 NMGGKSTYIRQTGVIVLMAQIGCFVPCESAEVSIVDCILARVGAGDSQLKGVSTFMAEML 730
Query: 813 ETSYILKGATNRSMAILDEIGRGTSRSEGVAIAYATLKYLTTNNACRALFATHFG--TEL 870
ET+ IL+ AT S+ I+DE+GRGTS +G +A+A +Y+ T +FATHF T L
Sbjct: 731 ETASILRSATKDSLIIIDELGRGTSTYDGFGLAWAISEYIATKIGAFCMFATHFHELTAL 790
Query: 871 ASTINSTSNEEFINNISFFKTGIIGDNSNFYYDHKLKPGICSKSDAIKVAKLAGFPEEAL 930
A+ I + +N + +++K G+C +S I VA+LA FP+ +
Sbjct: 791 ANQIPTVNN---------LHVTALTTEETLTMLYQVKKGVCDQSFGIHVAELANFPKHVI 841
Query: 931 EIA 933
E A
Sbjct: 842 ECA 844
>CE21000 [L] KOG0219 Mismatch repair ATPase MSH2 (MutS family)
Length = 849
Score = 186 bits (471), Expect = 2e-46
Identities = 169/603 (28%), Positives = 280/603 (46%), Gaps = 67/603 (11%)
Query: 348 MQIDSRTSTALELHSTMRKHHKKGS---LLSTIRRTVTTSGTRLLTQWLSAPSMDINEIK 404
M IDS ALEL + +K + L + + + T G +LL WLS P I+ I
Sbjct: 271 MLIDSCAVEALELFQLNYNYLEKSNNLTLYNVLNKCKTLPGEKLLRDWLSRPLCQIDHIN 330
Query: 405 NRQSLVLLFKDNFDYTESLI-RYLKETADMSRIIQRFSFGRGDPLELIQIAKSLRKC--K 461
R +V +N + L L D S++ +R +RKC +
Sbjct: 331 ERLDIVEALFENQTIRQKLRDSILARMPDCSQLARRL----------------MRKCTLQ 374
Query: 462 EISEYLQTNVHPSTKKTEKLIKNITKQLNFEDPIVEKVISSLNEESLIKQWSEKYERDDE 521
+++ + Q T + + + + +Q P + +++ S E L K E+++ +
Sbjct: 375 DLNRFYQAATLLETVEMQLIQLSEAEQFA---PSINRLLKSEITEILKKV--ERFQVLCD 429
Query: 522 EKFDASEENQERKSLVMIMKPSASQKLKEYYKSYNILIKEKESLLQWYKDWFLERFKLKN 581
E FD E + ++ V + Q++ E +++ E + + + + +F+ N
Sbjct: 430 EFFDFDYEKENKEIRVRVDFVPEIQEISEK-------LEQMERVAEKLRKKYSAKFECDN 482
Query: 582 VSLKQKNSGEFCIHLS-GSIANVVEFDKYIEQQKDSSQAHSGFHVLQKSRQTRWIIHDKW 640
+ L + + F ++ ++ + D +I + S L H K+
Sbjct: 483 LKLDKNSQYGFYFRVTLKEEKSIRKKDVHILETTKGSGVKFSVGELSDINDEFLEFHLKY 542
Query: 641 ETLSREIEVVGALIKNEEERLINQFQKDFISLSPMIRSLSQTLDYMDVLTSFAKLA---I 697
E EV+ L K EE FI L P + L TLD L++FA +
Sbjct: 543 TRA--EEEVISMLCKKAEE---------FIPLIPAMAQLIATLDVFVSLSTFAATSSGIY 591
Query: 698 EQRLVLPKVTQGTELNIKGGRHLVVEASISQKSLESFTPNDCQINSGELWVITGPNMGGK 757
+ +LP ++ EL K RH V+E + S + F PND ++ L ++TG NMGGK
Sbjct: 592 TRPNLLPLGSKRLEL--KQCRHPVIEGN----SEKPFIPNDVVLDKCRLIILTGANMGGK 645
Query: 758 STFLRQNAIIVILAQIGSFVPCESAVIGLVDKIFSRVGSADDLYNEMSTFMVEMIETSYI 817
ST+LR A+ ++LAQIGSFVPC SA I +VD IF+RVG++D +STFM EM++ S I
Sbjct: 646 STYLRSAALSILLAQIGSFVPCSSATISVVDGIFTRVGASDKQSQGISTFMAEMLDCSAI 705
Query: 818 LKGATNRSMAILDEIGRGTSRSEGVAIAYATLKYLTTNNACRALFATHFGT--ELASTIN 875
L+ AT S ++DE+GRGTS +G IA A + + C ++FATHF +LA
Sbjct: 706 LQRATKNSFVVIDELGRGTSTFDGFGIASAIAQDILNRIQCLSIFATHFHEMGKLAEQPG 765
Query: 876 STSNEEFINNISFFKTGIIGDNSNFYYDHKLKPGICSKSDAIKVAKLAGFPEEALEIAST 935
+ + + G+ +N+ + +K+ G+ S ++VAK+ G E + A+
Sbjct: 766 AVA----------LQMGVQIENNEIHMLYKVFEGVAQCSFGLQVAKMVGIDENVINKAAQ 815
Query: 936 LLE 938
LLE
Sbjct: 816 LLE 818
>ECU10g0710 [L] KOG0217 Mismatch repair ATPase MSH6 (MutS family)
Length = 922
Score = 181 bits (460), Expect = 4e-45
Identities = 219/879 (24%), Positives = 359/879 (39%), Gaps = 125/879 (14%)
Query: 78 DVMDKYTGHVVLTQIGSFYELYFEHATIYAPILNITLTSKSIVSGKVPFAGFPLNQLNRH 137
D+ + +V + G FYELY A + A + ++ +T + + +GFP L+
Sbjct: 145 DIKKDFFDTIVFFKKGKFYELYENDALVGARLFDLKITDRV----NMKMSGFPEGSLDYW 200
Query: 138 LKVLVKQYGYSVAVCDQFKH---ETLVDND---------KNKFMRR-VTRIVTPGTFIDE 184
+ + ++GY +A +Q ++ + + + D K+K +RR + I+T GT
Sbjct: 201 SRKFL-EHGYKIARVEQSENMIGKQIRERDEMSKEGRVVKDKIIRRELKEIITQGTIYSI 259
Query: 185 AFENFQENQYLLTVHFSENCMKRAADLNIPVGLSWCDISTGEIFVQQVYLKDLVSSITRI 244
+ YL++V E C + + D S GE++ + D S I
Sbjct: 260 DYMRSAMPMYLMSVATDEVCYSETCSGEVHTSVVLYDASIGEVYFSS-FCDD--RSHHGI 316
Query: 245 RPMEVLLDEEIMPVEITNGEWYKELTELKKYFIKYQKMPSKHRPIQSFFKLFSNAEGDIG 304
R + D + M + + G + + P K + + FSN
Sbjct: 317 RTILSQHDVKEMIADFSIGGVPRVV-------------PDKTACVSNRKYEFSN------ 357
Query: 305 RSLGNFTQKEIAALRNLLLYIEE-HLPDINTNLELPQKQLITDIMQIDSRTSTALELHST 363
++E + L+ Y+E+ D N+++ + Q M ID T +E+
Sbjct: 358 -------EREYVCFQYLMRYMEKLRRADALMNVKISRLQDEARTMGIDDATLRNMEIFKN 410
Query: 364 MRKHHKKGSLLSTIRRTVTTSGTRLLTQWLSAPSMDINEIKNRQSLVLLFKDNFDYTESL 423
+ +L + T G RLL +W+ AP + +I RQ + L+FK D T+ L
Sbjct: 411 NYNGTDEKTLFKAVDFCSTPFGQRLLRRWMMAPLVRKEDIVKRQEMALVFK-RMDSTK-L 468
Query: 424 IRYLKETADMSRIIQRFSFGRGDPLELIQIAKSLRKCKEISEYLQTNVHPSTKKTEKLIK 483
L D R++ R G +L + + L CKE + L +
Sbjct: 469 KEALGRIGDGERLLVRLYNGNPTAKDLSKFIRCLGACKETFDVLGMELR----------- 517
Query: 484 NITKQLNFEDPIVEKV--ISSLNEESLIKQWSEKYERDDEEKFDASEENQERKSLVMIMK 541
T++L IVEK S EE L+ W K E EEN++ +M K
Sbjct: 518 --TRRLEGARDIVEKAEDYSCRIEEVLV--WHRKVYDVTEAGISPGEENEDELCHLMSEK 573
Query: 542 PSASQKLKEYYKSYNILIKEKESLLQWYKDWFLERFKLKNVSLKQKNSGEFCIHLSGSIA 601
L Y + ++ +L S++ ++ G+ +
Sbjct: 574 GKIEGDLDAYLQE--------------------QKTRLGCPSIRFRDVGKDVFQMEVPKE 613
Query: 602 NVVEFDKYIEQQKDSSQAHSGFHVLQKSRQTRWIIHDKWETLSREIEVVGALIKNEEERL 661
V D +I + SR R ++ E R + G+L++ R
Sbjct: 614 IGVPSDYFIMSSVKGVNRYY-------SRDLRKLVERYMECEERIFQSKGSLLR----RA 662
Query: 662 INQFQKDFISLSPMIRSLSQTLDYMDVLTSFAKLAIEQRLVLPKVTQGTELNIKGGRHLV 721
I+ I + L+Q +D SFA + R P + T+L G
Sbjct: 663 IDVLLPHVIFFRQVFCELAQ----IDCYLSFATFSQRNRTSTPVFS--TKLCFSG----- 711
Query: 722 VEASISQKSLESFTPNDCQINSGELWVITGPNMGGKSTFLRQNAIIVILAQIGSFVPCES 781
+S +F ND + V+TG NMGGKST LR VIL+Q+G V C+
Sbjct: 712 ----MSSPIYPAFVENDYD-GCRRILVLTGANMGGKSTLLRTICFNVILSQVGMDVCCKR 766
Query: 782 AVIGLVDKIFSRVGSADDLYNEMSTFMVEMIETSYILKGATNRSMAILDEIGRGTSRSEG 841
L D+IF+R+G+ DDL STFM+E+ ETS IL+ +T S+ I+DE+GRGTS +G
Sbjct: 767 METPLFDRIFTRIGARDDLAKGESTFMIELGETSNILRHSTRDSLVIMDELGRGTSTKDG 826
Query: 842 VAIAYATLKYLTTNNACRALFATHFGTELASTINSTSNEEFINNISFFKTGIIGDNSNFY 901
IA A L+YL C LF+TH+ + + SN + + I G + F
Sbjct: 827 GCIARAVLEYL-KKKECHVLFSTHY-HGIIGEVEGVSN-------GYMSSVIKGRDIVFL 877
Query: 902 YDHKLKPGICSKSDAIKVAKLAGFPEEALEIASTLLEEI 940
Y KL G+ S + VA++AG P+ +E A + +E+
Sbjct: 878 Y--KLVAGVSGDSHGLYVARMAGVPDAIVERAEGIRKEL 914
>YDR097c [L] KOG0217 Mismatch repair ATPase MSH6 (MutS family)
Length = 1242
Score = 175 bits (444), Expect = 3e-43
Identities = 219/937 (23%), Positives = 384/937 (40%), Gaps = 142/937 (15%)
Query: 67 NSLPPSLQYVRDVMDKYTGHVVLTQIGSFYELYFEHATIYAPILNITLTSKSIVSGKVPF 126
N P + ++ K +V + G F+ELY + A + + ++ + +
Sbjct: 309 NKFTPFEKQYWEIKSKMWDCIVFFKKGKFFELYEKDALLANALFDLKIAGGG--RANMQL 366
Query: 127 AGFPLNQLNRHLKVLVKQYGYSVAVCDQFKH---ETLVDNDKNKFMRRVTRIVTPGTFID 183
AG P + Q GY VA DQ + + + + K R + I+T GT D
Sbjct: 367 AGIPEMSFEYWAAQFI-QMGYKVAKVDQRESMLAKEMREGSKGIVKRELQCILTSGTLTD 425
Query: 184 EAFENFQENQYLLTVH------FSENCMKRAA---DLNIPV-GLSWCDISTGEI----FV 229
+ + L + ++E + + LN + G ++ D +TGE+ F
Sbjct: 426 GDMLHSDLATFCLAIREEPGNFYNETQLDSSTIVQKLNTKIFGAAFIDTATGELQMLEFE 485
Query: 230 QQVYLKDLVSSITRIRPMEVLLDEEIMPV-----------------EITNGEWY----KE 268
L + ++++RPMEV+++ + E+ GE + K
Sbjct: 486 DDSECTKLDTLMSQVRPMEVVMERNNLSTLANKIVKFNSAPNAIFNEVKAGEEFYDCDKT 545
Query: 269 LTEL--KKYFIKYQKMPSKHRPIQSFFKLFSNAEGDIGRSLGNFTQKEIAALRNLLLYIE 326
E+ +YF + P ++S++ D G+ +G +A LL Y++
Sbjct: 546 YAEIISSEYFSTEEDWPEV---LKSYY--------DTGKKVG------FSAFGGLLYYLK 588
Query: 327 EHLPDINT----NLELPQKQLITDIMQIDSRTSTALELHSTMRKHHKKGSLLSTIRRTVT 382
D N N++ M +D T LE+ S KG+L R +T
Sbjct: 589 WLKLDKNLISMKNIKEYDFVKSQHSMVLDGITLQNLEIFSNSFDGSDKGTLFKLFNRAIT 648
Query: 383 TSGTRLLTQWLSAPSMDINEIKNRQSLVLLFKDNFDYTESLIRYLKETADMSRIIQRFSF 442
G R++ +WL P + N+I++R V + E L + D+ R++ R
Sbjct: 649 PMGKRMMKKWLMHPLLRKNDIESRLDSVDSLLQDITLREQLEITFSKLPDLERMLARIHS 708
Query: 443 GRGDPLELIQIAKSLRKCKEISEYLQTNVHPSTKKTEKLIKNITKQLN-FEDPIVEKVIS 501
+ ++ + E+ + L+ N L +++K ++ F + +VE V
Sbjct: 709 RTIKVKDFEKVITAFETIIELQDSLKNN---------DLKGDVSKYISSFPEGLVEAV-- 757
Query: 502 SLNEESLIKQWSEKYERDDEEKFDASEENQERKSLVMIMKPSASQKLKEYYKSYNILIKE 561
K W+ +ER A EN I+ P + E+ KS + I+E
Sbjct: 758 --------KSWTNAFERQK-----AINEN--------IIVPQRGFDI-EFDKSMD-RIQE 794
Query: 562 KESLLQWYKDWFLERFKLKNVSLKQKNSGEFCIHLSGSIANVVEFDKYIEQQKDSSQAHS 621
E L + ++FK N+ K + I + S V S
Sbjct: 795 LEDELMEILMTYRKQFKCSNIQYKDSGKEIYTIEIPISATKNVP---------------S 839
Query: 622 GFHVLQKSRQTRWIIHDKWETLSREIEVVGALIKNEEERLINQFQKDF------------ 669
+ + ++ + D+ L+R + + K EE L N+ + F
Sbjct: 840 NWVQMAANKTYKRYYSDEVRALARSMAEAKEIHKTLEEDLKNRLCQKFDAHYNTIWMPTI 899
Query: 670 --ISLSPMIRSLSQTLDYMDVLTSFAKLAIEQRLVLPKVTQGTELNIKGGRHLVVEASIS 727
IS + ++++T +Y+ + + E G L K RH ++
Sbjct: 900 QAISNIDCLLAITRTSEYLGAPSCRPTIVDEVDSKTNTQLNGF-LKFKSLRHPCF--NLG 956
Query: 728 QKSLESFTPNDCQINSGE--LWVITGPNMGGKSTFLRQNAIIVILAQIGSFVPCESAVIG 785
+ + F PND ++ + L ++TG N GKST LR I VI+AQ+G +VPCESAV+
Sbjct: 957 ATTAKDFIPNDIELGKEQPRLGLLTGANAAGKSTILRMACIAVIMAQMGCYVPCESAVLT 1016
Query: 786 LVDKIFSRVGSADDLYNEMSTFMVEMIETSYILKGATNRSMAILDEIGRGTSRSEGVAIA 845
+D+I +R+G+ D++ STF VE+ ET IL ATNRS+ ++DE+GRG S S+G AIA
Sbjct: 1017 PIDRIMTRLGANDNIMQGKSTFFVELAETKKILDMATNRSLLVVDELGRGGSSSDGFAIA 1076
Query: 846 YATLKYLTTNNACRALFATHFGTELASTINSTSNEEFINNISFFKTGIIGDNS--NFYYD 903
+ L ++ T+ FATH+GT LAS+ + K I+ D + N +
Sbjct: 1077 ESVLHHVATHIQSLGFFATHYGT-LASSFKHHP------QVRPLKMSILVDEATRNVTFL 1129
Query: 904 HKLKPGICSKSDAIKVAKLAGFPEEALEIASTLLEEI 940
+K+ G S + VA + G +E ++ A + +
Sbjct: 1130 YKMLEGQSEGSFGMHVASMCGISKEIIDNAQIAADNL 1166
>CE28985 [L] KOG0217 Mismatch repair ATPase MSH6 (MutS family)
Length = 1186
Score = 171 bits (433), Expect = 5e-42
Identities = 233/937 (24%), Positives = 408/937 (42%), Gaps = 149/937 (15%)
Query: 87 VVLTQIGSFYELYFEHATIYAPILNITLTSKSIVSGKVPFAGFPLNQLNRHLKVLVKQYG 146
++L ++G FYE Y A LNI + + G AGFP + ++ L+ +G
Sbjct: 268 ILLFKVGKFYETYHMDAVEVVRALNI-----AFMRGSYAHAGFPEHAASKFADQLMN-HG 321
Query: 147 YSVAVCDQFKHETLVDN------DKNKFMRR-VTRIVTPGTFIDEAFENFQEN------- 192
Y VA +Q + +++ K K +RR V R+ + GT +
Sbjct: 322 YKVARIEQTETPQMLEERNQKTKTKEKVVRREVCRVTSNGTRTYGVLDGVDLGSASSTLD 381
Query: 193 ---QYLLTVHFSEN----------CMKRAADLNIPVGLSWCD--------ISTGEIFVQQ 231
++LL + N CM +I +G D + I VQ
Sbjct: 382 PTAKHLLAIKEFHNPETGKSSYGVCMIDTTTAHIRIGQFEDDDYRSQLRTLLANVIVVQA 441
Query: 232 VYLKDLVSSITRIR--------PMEVLLDE-EIMPVE-----ITNGEWY----KELTELK 273
+ + +SS T+ P+E LL + + M E ++N ++Y E E+
Sbjct: 442 IVERGSISSTTKSIINGILFSVPVEHLLPKKQFMTAEDVVRIVSNEDYYGSDASEWPEVL 501
Query: 274 KYFIKYQKMPSKHRPIQSFFKLFSNAEGDIGRSL-GNFTQKEIAALRNLLLYIEEHLPDI 332
K ++ + K + ++L +A G I L + ++ ++RN+ +Y + +
Sbjct: 502 KGMLEDSSILPKP---STDWQLALSAFGAIFWYLRDSLIDVDMLSMRNVTIYNSNSMEND 558
Query: 333 NTN--LELPQKQLITDIMQIDSRTSTALELHSTMRKHHKKGSLLSTIRRTVTTSGTRLLT 390
++ K LI D +++ L + R H SL I + T G RLL
Sbjct: 559 QKKEKIDWNGKNLILDGTALEN-----LNIVPNGRDSHLT-SLYYVINKCSTPFGRRLLR 612
Query: 391 QWLSAPSMDINEIKNRQSLV--LLFKDNFDYTESLIRYLKETADMSRIIQRFSFGRGDPL 448
WL P+ D +++ RQ + L+ D + + LK+ D+ R++Q+ +
Sbjct: 613 SWLLQPTCDPKKLEQRQKAIKWLVSPDASSFMTTATATLKKIPDLDRLLQK--------I 664
Query: 449 ELIQIAKSLRKCKEISEYLQTNVHPSTKKTEKLIKNIT-----KQLNFEDPIVEKVISSL 503
I + K + + + KK +L+ I +L E V+K
Sbjct: 665 HTIGLKYRSEKHPDSRAIFFDTIKTNQKKIAELLAAIDGFKLCNKLRKEYIKVQKEGEGC 724
Query: 504 NE-ESLIKQWSEKYERDD-----EEKFDASEENQERKSLVMIMKPSASQKLKEYYKSYNI 557
+ L+ E E D+ E+ FD S ++ K + P+A +EY ++ N
Sbjct: 725 ELLDELLGNEQEMEEVDENIYFFEKMFDRSTAMKDGKIV-----PNAGCD-EEYDEALN- 777
Query: 558 LIKEKESLLQWYKDWFLERFKLKNVSLKQKNSGEFCIHLSGSIANVVEFDKYIEQQKDSS 617
+KE + L YKD +++ + S+K +SG+ KY+ + +++
Sbjct: 778 RVKEALNELNDYKDSVAKKY---SCSIKFVDSGKV---------------KYLLEMPENT 819
Query: 618 QAHSGFHVLQKSRQTRWIIHDKWETLSREIEVVGALIKNEEER------LINQFQKDFIS 671
+ S F + KSR+ +I ++ T E ++V AL E+E+ + + F
Sbjct: 820 KVSSSFEL--KSRRKGFI---RYSTPDSE-QLVAALDAVEKEKSKLGDDATRRVFEQFGH 873
Query: 672 LSPMIRSLSQTLDYMDVLTSFAKLAIEQ--RLVLPKVTQGTE---LNIKGGRH--LVVEA 724
+P+ + + DVLTS A A + +P+ L + G H L +++
Sbjct: 874 KNPIWLETVKLVSSFDVLTSLALFAKSSPFEMCMPEFDFNATDPYLIVDKGVHPCLALQS 933
Query: 725 SISQKSLESFTPNDCQINSGE--LWVITGPNMGGKSTFLRQNAIIVILAQIGSFVPCESA 782
SF N + + E + ++TGPNMGGKST +RQ A++ ILA IGS VP S
Sbjct: 934 RNEVTQTTSFIANSTTMGASEAAVMLLTGPNMGGKSTLMRQTAVLAILAHIGSMVPAFSM 993
Query: 783 VIGLVDKIFSRVGSADDLYNEMSTFMVEMIETSYILKGATNRSMAILDEIGRGTSRSEGV 842
+ +D+IF+R+G+ D + STF +E+ ET +LK AT S+ ++DE+GRGTS +G
Sbjct: 994 RLTPIDRIFTRIGANDRIMCGESTFFIELKETDIMLKNATKHSLLLVDELGRGTSTFDGT 1053
Query: 843 AIAYATLKYLTTNNACRALFATHFGTELASTINSTSNEEFINNISFFKTGIIGDNS---- 898
AIA A L+ ++ + ACR F+TH+ S +S +N + ++ K + +N+
Sbjct: 1054 AIASAVLQKISDDLACRTFFSTHY----HSICDSFTNHPNV-RLAHMKCVVDKENNEDPT 1108
Query: 899 --NFYYDHKLKPGICSKSDAIKVAKLAGFPEEALEIA 933
+ + ++L+ GIC KS AKLAG + + A
Sbjct: 1109 MEDVTFLYELESGICPKSYGFYAAKLAGIDHQVVRNA 1145
>7298155 [L] KOG0219 Mismatch repair ATPase MSH2 (MutS family)
Length = 854
Score = 169 bits (429), Expect = 1e-41
Identities = 109/313 (34%), Positives = 168/313 (52%), Gaps = 27/313 (8%)
Query: 638 DKWETLSREIEVVGALIKNEEERLINQFQKDFISLSPMIRSLSQTLDYMDVLTSFAKLA- 696
DK E + E + ++ ++ + + + + L+ L +D L SFA A
Sbjct: 489 DKLEGYADEFASCRTRYEEQQLSIVEEIIHVAVGYAAPLTLLNNELAQLDCLVSFAIAAR 548
Query: 697 -IEQRLVLPKVTQGTELNIKGGRHLVVEASISQKSLE-----SFTPNDCQINSGE--LWV 748
V PK+ + +G R LV+E + LE +F N E +++
Sbjct: 549 SAPTPYVRPKMLE------EGARELVLE-DVRHPCLELQEHVNFIANSVDFKKEECNMFI 601
Query: 749 ITGPNMGGKSTFLRQNAIIVILAQIGSFVPCESAVIGLVDKIFSRVGSADDLYNEMSTFM 808
ITGPNMGGKST++R V++A IG+FVPC A I +VD I RVG++D++ +STFM
Sbjct: 602 ITGPNMGGKSTYIRSVGTAVLMAHIGAFVPCSLATISMVDSILGRVGASDNIIKGLSTFM 661
Query: 809 VEMIETSYILKGATNRSMAILDEIGRGTSRSEGVAIAYATLKYLTTNNACRALFATHFG- 867
VEMIETS I++ AT++S+ I+DE+GRGTS EG IA++ ++L C LFATHF
Sbjct: 662 VEMIETSGIIRTATDKSLVIIDELGRGTSTYEGCGIAWSIAEHLAKETKCFTLFATHFHE 721
Query: 868 -TELASTINSTSNEEFINNISFFKTGIIGDNSNFYYDHKLKPGICSKSDAIKVAKLAGFP 926
T+LA T+++ N + D +F ++++ G+ KS I+VA+LA FP
Sbjct: 722 ITKLAETLSTVKN---------CHMAAVADADDFTLLYQVRSGVMEKSFGIQVARLANFP 772
Query: 927 EEALEIASTLLEE 939
E ++ A + E
Sbjct: 773 EHVVQNAQEVYNE 785
>Hs4504191 [L] KOG0217 Mismatch repair ATPase MSH6 (MutS family)
Length = 1360
Score = 166 bits (421), Expect = 1e-40
Identities = 211/946 (22%), Positives = 382/946 (40%), Gaps = 116/946 (12%)
Query: 67 NSLPPSLQYVRDVMDKYTGHVVLTQIGSFYELYFEHATIYAPILNITLTSKSIVSGKVPF 126
NS P ++ + + V+ ++G FYELY A I L + + G
Sbjct: 404 NSCTPGMRKWWQIKSQNFDLVICYKVGKFYELYHMDALIGVSELGLVF-----MKGNWAH 458
Query: 127 AGFPLNQLNRHLKVLVKQYGYSVAVCDQFKHETLVDNDKNKFM----------RRVTRIV 176
+GFP R+ LV Q GY VA +Q + +++ K R + RI+
Sbjct: 459 SGFPEIAFGRYSDSLV-QKGYKVARVEQTETPEMMEARCRKMAHISKYDRVVRREICRII 517
Query: 177 TPGTFIDEAFENFQE---NQYLLTVHFSENCMKRAADLNIPVGLSWCDISTGEIFVQQV- 232
T GT E ++YLL++ E + ++ G+ + D S G+ F+ Q
Sbjct: 518 TKGTQTYSVLEGDPSENYSKYLLSLKEKE---EDSSGHTRAYGVCFVDTSLGKFFIGQFS 574
Query: 233 ---YLKDLVSSITRIRPMEVLLDEEIMPVE----------------ITNGEWYKELTELK 273
+ + + P++VL ++ + E + G + + ++
Sbjct: 575 DDRHCSRFRTLVAHYPPVQVLFEKGNLSKETKTILKSSLSCSLQEGLIPGSQFWDASKTL 634
Query: 274 KYFIKYQKMPSKHRP-----IQSFFKLFSNAEGDIGRSLGNFTQKEIAALRNLLLYI--- 325
+ ++ + K + K ++ IG + G ++ ++AL + Y+
Sbjct: 635 RTLLEEEYFREKLSDGIGVMLPQVLKGMTSESDSIGLTPGEKSELALSALGGCVFYLKKC 694
Query: 326 ------------EEHLP-DINTNLELPQKQLITDIMQ---IDSRTSTALELHSTMRKHHK 369
EE++P D +T + T Q +D+ T LE+
Sbjct: 695 LIDQELLSMANFEEYIPLDSDTVSTTRSGAIFTKAYQRMVLDAVTLNNLEIFLNGTNGST 754
Query: 370 KGSLLSTIRRTVTTSGTRLLTQWLSAPSMDINEIKNRQSLVLLFKDNFDYTESLIRYLKE 429
+G+LL + T G RLL QWL AP + I +R + D ++ LK+
Sbjct: 755 EGTLLERVDTCHTPFGKRLLKQWLCAPLCNHYAINDRLDAIEDLMVVPDKISEVVELLKK 814
Query: 430 TADMSRIIQRFSFGRGDPLELIQIAKSLRKCKEISEYLQTNVHPSTKKTEKL-----IKN 484
D+ R++ + G PL+ S E + Y + + E I
Sbjct: 815 LPDLERLLSKIH-NVGSPLKSQNHPDSRAIMYEETTYSKKKIIDFLSALEGFKVMCKIIG 873
Query: 485 ITKQL--NFEDPIVEKVIS--SLNEESLIKQWSEKYERDDEEKFDASEENQERKSLVMIM 540
I +++ F+ I+++VIS + N E + + R D A + + RK+ ++
Sbjct: 874 IMEEVADGFKSKILKQVISLQTKNPEGRFPDLTVELNRWDT----AFDHEKARKTGLITP 929
Query: 541 KPSASQKLKEYYKSYNILIKEKESLLQWYKDWFLERFKLKNVSLKQKNSGEFCIHLSGSI 600
K + I+E E L Y + R + + + + + +
Sbjct: 930 KAGFDSDYDQALAD----IRENEQSLLEYLEKQRNRIGCRTIVYWGIGRNRYQLEIPENF 985
Query: 601 ANVVEFDKYIEQQKDSSQAHSGFHVLQKSRQTRWIIHDKWETLSREIEVVGALIKNEEER 660
+ + ++ + G R I K L E +K+ R
Sbjct: 986 TT-----RNLPEEYELKSTKKGC-----KRYWTKTIEKKLANLINAEERRDVSLKDCMRR 1035
Query: 661 LINQFQKDFISLSPMIRSLSQTLDYMDVLTSFAKLA----IEQRLVLPKVTQGTELNIKG 716
L F K++ + ++ LD + L ++++ ++LP+ T L +KG
Sbjct: 1036 LFYNFDKNYKDWQSAVECIA-VLDVLLCLANYSRGGDGPMCRPVILLPEDTPPF-LELKG 1093
Query: 717 GRHLVVEASISQKSLESFTPNDCQINSGE---------LWVITGPNMGGKSTFLRQNAII 767
RH + + + F PND I E ++TGPNMGGKST +RQ ++
Sbjct: 1094 SRHPCITKTFFG---DDFIPNDILIGCEEEEQENGKAYCVLVTGPNMGGKSTLMRQAGLL 1150
Query: 768 VILAQIGSFVPCESAVIGLVDKIFSRVGSADDLYNEMSTFMVEMIETSYILKGATNRSMA 827
++AQ+G +VP E + +D++F+R+G++D + + STF VE+ ET+ IL AT S+
Sbjct: 1151 AVMAQMGCYVPAEVCRLTPIDRVFTRLGASDRIMSGESTFFVELSETASILMHATAHSLV 1210
Query: 828 ILDEIGRGTSRSEGVAIAYATLKYLTTNNACRALFATHFGTELASTINSTSNEEFINNIS 887
++DE+GRGT+ +G AIA A +K L CR LF+TH+ + + + + + +++
Sbjct: 1211 LVDELGRGTATFDGTAIANAVVKELAETIKCRTLFSTHYHSLVEDYSQNVAVR--LGHMA 1268
Query: 888 FFKTGIIGDNS--NFYYDHKLKPGICSKSDAIKVAKLAGFPEEALE 931
D S + +K G C KS A+LA PEE ++
Sbjct: 1269 CMVENECEDPSQETITFLYKFIKGACPKSYGFNAARLANLPEEVIQ 1314
>SPBC24C6.12c [L] KOG0219 Mismatch repair ATPase MSH2 (MutS family)
Length = 434
Score = 162 bits (411), Expect = 2e-39
Identities = 98/237 (41%), Positives = 140/237 (58%), Gaps = 22/237 (9%)
Query: 712 LNIKGGRHLVVEASISQKSLESFTPNDCQINSG--ELWVITGPNMGGKSTFLRQNAIIVI 769
L +K RH +EA K F PND + G EL +ITGPNMGGKST++RQ +I +
Sbjct: 136 LYLKQARHPCLEAQDDVK----FIPNDVNLEHGSSELLIITGPNMGGKSTYIRQVGVITV 191
Query: 770 LAQIGSFVPCESAVIGLVDKIFSRVGSADDLYNEMSTFMVEMIETSYILKGATNRSMAIL 829
+AQIG VPCE A + ++D I +RVG++D +STFM EM+ET+ IL+ AT RS+ I+
Sbjct: 192 MAQIGCPVPCEVADLDIIDAILARVGASDSQLKGISTFMAEMLETATILRAATPRSLIII 251
Query: 830 DEIGRGTSRSEGVAIAYATLKYLTTNNACRALFATHFG--TELASTINSTSNEEFINNIS 887
DE+GRGTS ++G +A+A +++ T C LFATH+ T+L+ I + N
Sbjct: 252 DELGRGTSTTDGFGLAWAITEHIVTQIGCFCLFATHYHEMTKLSEEITTVKN-------- 303
Query: 888 FFKTGIIGDNSNFYYDHKLKPGIC----SKSDAIKVAKLAGFPEEALEIASTLLEEI 940
T +GD+ + D L +C +S I VAKLA FP + +E+AS E+
Sbjct: 304 LHVTAYVGDSES--KDVALLYNVCEGASDRSFGIHVAKLAHFPPKIIEMASNKAAEL 358
>ECU03g0540 [L] KOG0219 Mismatch repair ATPase MSH2 (MutS family)
Length = 730
Score = 154 bits (388), Expect = 8e-37
Identities = 149/560 (26%), Positives = 260/560 (45%), Gaps = 85/560 (15%)
Query: 382 TTSGTRLLTQWLSAPSMDINEIKNRQSLVLLFKDNFDYTESL-IRYLKETADMSRIIQRF 440
T G RLL + L P + +EI+ R +V D +L + LK D+ R+ +R
Sbjct: 252 TNQGWRLLHRMLLQPLRNKDEIERRLDIV-------DSLRTLNLGILKRFPDLLRLSKRV 304
Query: 441 SFGRGDPLELIQIAKSLRKCKEISEYLQTNVHPSTKKTEKLIKNITKQLNFEDPIVEKVI 500
S GR E++++A+++ E+ +++ S E L K + F + I +
Sbjct: 305 SSGRVSLREILRLAQTVDTIPELMSSFSSSLALSKDVGETLKKIFLAFVPFRNEITRVI- 363
Query: 501 SSLNEESLIKQWSEKYERDDEEKFDASEENQERKSLVMIMKPSASQKLKEYYKSYNILIK 560
+A+EEN R ++P S++L++ N +
Sbjct: 364 ----------------------DLEAAEENVYR------VRPDVSERLQKL----NRALA 391
Query: 561 EKESLLQWYKDWFLERFKLKNVSLKQKNSGEFCIHLSGSIANVVEFDKYIEQQKDSSQAH 620
E + +Q + + V +NSG F + E+ + + K
Sbjct: 392 EVDGKMQKEYERVCGIYPRAKVD---RNSGAFKTAKA-------EYQRSQDLFKKEGFVE 441
Query: 621 SGFHVLQKSRQTRWI--IHDKWETLSREIEVVGALIKNEEERLINQFQKDFISLSPMIRS 678
F S TR + ++++ E+L +EI+ +EE+ +++ + + +P + S
Sbjct: 442 LSFVKGGVSFTTRVLSLLNERRESLKKEID-------DEEKEIMDGVKTALKNYTPYLES 494
Query: 679 LSQTLDYMDVLTSFAKLAIEQRLVLPKVTQGTELNIKGGRHLVVEASISQKSLESFTPND 738
L+ +DV ++F+ A + P + GT L I+ G H V+E + + PN
Sbjct: 495 LNHLTALVDVFSAFSIKATLKGYSRP-IVGGTMLEIENGFHPVLED-------QDYIPNS 546
Query: 739 CQINSGELWVITGPNMGGKSTFLRQNAIIVILAQIGSFVPCESAVIGLVDKIFSRVGSAD 798
++ + V+TGPNMGGKSTFL+ +I +LA +G +VP E A I ++D I++RVG+ D
Sbjct: 547 IKMEDRRMCVVTGPNMGGKSTFLKTCGVIALLAHMGCYVPAEYASIPILDGIYTRVGAGD 606
Query: 799 DLYNEMSTFMVEMIETSYILKGATNRSMAILDEIGRGTSRSEGVAIAYATLKYLTTNNAC 858
+ STFM+EM + + I + ++ S+ I+DE+GRGTS +G++IA A ++L +
Sbjct: 607 CSFTGSSTFMMEMADIARICRLSSPESLIIIDELGRGTSAVDGLSIAQAVKEHLILKKSL 666
Query: 859 RALFATHFGTELASTINSTSNEEFINNISFFKTGIIGDNSNFYYDHKLKPGICSKSDAIK 918
L ATHF EL ++ +N + D + Y+ + GIC S I
Sbjct: 667 -CLCATHF-PELC-------GDDVLNKKA------KSDGTLLMYE--VVDGICDTSFGIM 709
Query: 919 VAKLAGFPEEALEIASTLLE 938
VA+ GFP E +E+A +E
Sbjct: 710 VAEKVGFPAEVIEMAKGYME 729
>At4g25540 [L] KOG0218 Mismatch repair MSH3
Length = 1076
Score = 149 bits (377), Expect = 2e-35
Identities = 96/285 (33%), Positives = 156/285 (54%), Gaps = 29/285 (10%)
Query: 663 NQFQKDFISLSPMIRSLSQTLDYMDVLTSFAKLAIEQRLVLPKVT---QGTELNIKGGRH 719
+ F K F ++ Q L +D L S + L+ + V P+ + E+NI+ GRH
Sbjct: 741 DSFLKSFSRYYTDFKAAVQALAALDCLHSLSTLSRNKNYVRPEFVDDCEPVEINIQSGRH 800
Query: 720 LVVEASISQKSLESFTPNDCQINS-GELW-VITGPNMGGKSTFLRQNAIIVILAQIGSFV 777
V+E + ++F PND +++ GE +ITGPNMGGKS ++RQ A+I I+AQ+GSFV
Sbjct: 801 PVLETILQ----DNFVPNDTILHAEGEYCQIITGPNMGGKSCYIRQVALISIMAQVGSFV 856
Query: 778 PCESAVIGLVDKIFSRVGSADDLYNEMSTFMVEMIETSYILKGATNRSMAILDEIGRGTS 837
P A + ++D +F+R+G++D + + STF+ E L+E+GRGTS
Sbjct: 857 PASFAKLHVLDGVFTRMGASDSIQHGRSTFLEE------------------LNELGRGTS 898
Query: 838 RSEGVAIAYATLKYLTTNNACRALFATHFG--TELASTINSTSNEEFINNISFFKTGIIG 895
+GVAIAYATL++L C LF TH+ E+++ + ++ ++ K
Sbjct: 899 THDGVAIAYATLQHLLAEKRCLVLFVTHYPEIAEISNGFPGSVGTYHVSYLTLQKDKGSY 958
Query: 896 DNSNFYYDHKLKPGICSKSDAIKVAKLAGFPEEALEIASTLLEEI 940
D+ + Y +KL G+CS+S KVA+LA P + A ++ ++
Sbjct: 959 DHDDVTYLYKLVRGLCSRSFGFKVAQLAQIPPSCIRRAISMAAKL 1003
>CE24714 [L] KOG0220 Mismatch repair ATPase MSH4 (MutS family)
Length = 842
Score = 143 bits (360), Expect = 1e-33
Identities = 172/682 (25%), Positives = 297/682 (43%), Gaps = 71/682 (10%)
Query: 278 KYQKMPSKHRPIQSFF--KLFSNAEGDIGRSLGNFTQKEIAALRNLLLYIEEHLPDINTN 335
KY R +QS ++ + +EG + R+L + AL LL YI E
Sbjct: 140 KYFNSERGERQLQSLMNAEVSTVSEGCLRRTLA------LGALAVLLKYIHETRCVFFRV 193
Query: 336 LELPQKQL-ITDIMQIDSRTSTALEL-----HSTMRKHH--KKGSLLSTIRRTVTTSGTR 387
L K++ + D ID + +LE+ S RK +K +L+S + TVTT+G R
Sbjct: 194 KSLRIKEMGVNDTCMIDFVSWESLEIVDADDASKARKFQMKQKRTLMSVLNHTVTTNGYR 253
Query: 388 LLTQWLSAPSMDINEIKNRQSLVLLFKDNFDYTESLIRYLKETADMSRIIQRFSFG---- 443
LL + PS D+ I++RQ + + L R L ++ R+I
Sbjct: 254 LLRSSVLQPSTDVYLIQSRQEAIEELIGKPQLKDKLRRTLSRAHELDRVIAMCIQTSTSW 313
Query: 444 --RGDPLELIQIAKSLRKCKEISEYLQTNVHPSTKKTEKLIKNITKQLNFEDPIVEKVIS 501
R ++ QI K + K I + ++T +H + K+ LI+ K +DP +++++
Sbjct: 314 TVRESEAKINQIIKLMHTLKVI-QGIRTLLHSAKMKSNILIE---KTEFLKDPRFDQIMN 369
Query: 502 SLNEESLIKQWSEKYERDDEEKFDASEENQERKSLVMIMKPSASQKLKEYYKSYNILIKE 561
L EK D S + ++ SL + Q K Y + + + +
Sbjct: 370 IL-----------------VEKVDDSLLDGKKNSLHL-------QNTKCYAIRHFVAV-Q 404
Query: 562 KESLLQWYKDWFLERFKLKNVSLKQKNSGEFCIHLSGSIANVVEFDKYIEQQKDSSQAHS 621
+ Q Y++ + + + G + LS S + + ++ +Q +S
Sbjct: 405 LDLARQTYEEIIRNVEETGAREIAEYFHGNSSVRLSFSQSRGFHYT-FVTRQAESVTIPR 463
Query: 622 GFHVLQKSRQTRWIIHDKWETLSREIEVVGALIKNEEERLINQFQKDFISLSPMIRSLSQ 681
F + ++R T K + +E V A + + ++ ++ + P++
Sbjct: 464 YFLDVFRNRTTVTFNSRKVIAYNDRLEQVVAEMFLASDVIVCDMIEEMQPMIPVLYYAMD 523
Query: 682 TLDYMDVLTSFAKLAIEQRLVLPKVTQGTELNIKGGRHLVVEASISQKSLESFTPNDCQI 741
L +D L A + + P T G +I GRH +++ S+K++ T + C
Sbjct: 524 ALSSIDFLCGLATYSDLRDTCKP--TFGPSFSISQGRHPILDWDDSEKTI---TNDTCLT 578
Query: 742 NSGELWVITGPNMGGKSTFLRQNAIIVILAQIGSFVPCESAVIGLVDKIFSRVGSADDLY 801
+ITGPNM GKST+L+Q A + I+AQIG F+P A + + ++IFSR+G D+L
Sbjct: 579 RDRRFGIITGPNMAGKSTYLKQTAQLAIMAQIGCFIPANYASLPIFNRIFSRMGHNDELI 638
Query: 802 NEMSTFMVEMIETSYILKGATNRSMAILDEIGRGTSRSEGVAIAYATLKYLTTNNACRAL 861
S F EM + + I++ A S+ +LDE+ R TS EG+AI YA + + + L
Sbjct: 639 RNKSAFASEMSDAAAIVQYADKNSLVVLDELARSTSTEEGIAITYAICEKVLKLQSYTFL 698
Query: 862 FATHF--GTELASTINSTSNEEFINNISFFKTGIIGDNSNFYYDHKLKPG-ICSKSDAIK 918
ATHF LA+ N+ N F+ + N HKL G +
Sbjct: 699 -ATHFLDIAALANYSNAIDNYHFLPQ----------TDENSTKKHKLLRGQYRGPLYGFE 747
Query: 919 VAKLAGFPEEALEIASTLLEEI 940
+ +L+ P+E +E A +L E+
Sbjct: 748 LVELSTIPDEVIEHAQSLATEL 769
>Hs4505251 [L] KOG0220 Mismatch repair ATPase MSH4 (MutS family)
Length = 936
Score = 141 bits (356), Expect = 4e-33
Identities = 97/274 (35%), Positives = 146/274 (52%), Gaps = 26/274 (9%)
Query: 679 LSQTLDYMDVLTSFAKLAIEQRLVLPKVTQGTELNIKGGRHLVVEASISQKSLESFTPND 738
LS T+ +D+L SFA V P+ T L IK G H ++E ++K + + N
Sbjct: 613 LSDTVSMLDMLLSFAHACTLSDYVRPEFTD--TLAIKQGWHPILEKISAEKPIAN---NT 667
Query: 739 CQINSGELWVITGPNMGGKSTFLRQNAIIVILAQIGSFVPCESAVIGLVDKIFSRVGSAD 798
+ITGPNM GKST+L+Q A+ I+AQIGS+VP E + + +IF+R+ + D
Sbjct: 668 YVTEGSNFLIITGPNMSGKSTYLKQIALCQIMAQIGSYVPAEYSSFRIAKQIFTRISTDD 727
Query: 799 DLYNEMSTFMVEMIETSYILKGATNRSMAILDEIGRGTSRSEGVAIAYATLKYLTTNNAC 858
D+ STFM EM E +YIL A ++S+ ++DE+GRGT+ EG+ I YA +YL + A
Sbjct: 728 DIETNSSTFMKEMKEIAYILHNANDKSLILIDELGRGTNTEEGIGICYAVCEYLLSLKAF 787
Query: 859 RALFATHFGTELA-------STINSTSNEEFINNISFFKTGIIGDNSNFYYDHKLKPGIC 911
LFATHF EL + N + + N S K I+ Y +KL G+
Sbjct: 788 -TLFATHF-LELCHIDALYPNVENMHFEVQHVKNTSRNKEAIL-------YTYKLSKGLT 838
Query: 912 -SKSDAIKVAKLAGFPE----EALEIASTLLEEI 940
K+ +K A+++ P +A EI + + +I
Sbjct: 839 EEKNYGLKAAEVSSLPPSIVLDAKEITTQITRQI 872
>Hs20535615 [L] KOG0220 Mismatch repair ATPase MSH4 (MutS family)
Length = 936
Score = 141 bits (356), Expect = 4e-33
Identities = 97/274 (35%), Positives = 146/274 (52%), Gaps = 26/274 (9%)
Query: 679 LSQTLDYMDVLTSFAKLAIEQRLVLPKVTQGTELNIKGGRHLVVEASISQKSLESFTPND 738
LS T+ +D+L SFA V P+ T L IK G H ++E ++K + + N
Sbjct: 613 LSDTVSMLDMLLSFAHACTLSDYVRPEFTD--TLAIKQGWHPILEKISAEKPIAN---NT 667
Query: 739 CQINSGELWVITGPNMGGKSTFLRQNAIIVILAQIGSFVPCESAVIGLVDKIFSRVGSAD 798
+ITGPNM GKST+L+Q A+ I+AQIGS+VP E + + +IF+R+ + D
Sbjct: 668 YVTEGSNFLIITGPNMSGKSTYLKQIALCQIMAQIGSYVPAEYSSFRIAKQIFTRISTDD 727
Query: 799 DLYNEMSTFMVEMIETSYILKGATNRSMAILDEIGRGTSRSEGVAIAYATLKYLTTNNAC 858
D+ STFM EM E +YIL A ++S+ ++DE+GRGT+ EG+ I YA +YL + A
Sbjct: 728 DIETNSSTFMKEMKEIAYILHNANDKSLILIDELGRGTNTEEGIGICYAVCEYLLSLKAF 787
Query: 859 RALFATHFGTELA-------STINSTSNEEFINNISFFKTGIIGDNSNFYYDHKLKPGIC 911
LFATHF EL + N + + N S K I+ Y +KL G+
Sbjct: 788 -TLFATHF-LELCHIDALYPNVENMHFEVQHVKNTSRNKEAIL-------YTYKLSKGLT 838
Query: 912 -SKSDAIKVAKLAGFPE----EALEIASTLLEEI 940
K+ +K A+++ P +A EI + + +I
Sbjct: 839 EEKNYGLKAAEVSSLPPSIVLDAKEITTQITRQI 872
>At4g17380 [L] KOG0220 Mismatch repair ATPase MSH4 (MutS family)
Length = 574
Score = 134 bits (336), Expect = 9e-31
Identities = 84/221 (38%), Positives = 136/221 (61%), Gaps = 17/221 (7%)
Query: 659 ERLINQFQKDFISLSPMIRSLSQTLDYMD-VLTSFAKLAIEQ---RLVLPKVTQGTELNI 714
E L++ ++D +L+ L++ L +D ++ SFA + R P++T L I
Sbjct: 301 EALMDAIREDISALT----LLAEVLCLLDMIVNSFAHTISTKPVDRYSRPELTDSGPLAI 356
Query: 715 KGGRHLVVEASISQKSLESFTPNDCQINSG-ELWVITGPNMGGKSTFLRQNAIIVILAQI 773
GRH ++E+ + F N ++ + V+ GPNM GKST+L+Q ++VILAQI
Sbjct: 357 DAGRHPILESIHND-----FVSNSIFMSEATNMLVVMGPNMSGKSTYLQQVCLVVILAQI 411
Query: 774 GSFVPCESAVIGLVDKIFSRVGSADDLYNEMSTFMVEMIETSYILKGATNRSMAILDEIG 833
G +VP A I +VD+IF+R+G+ D+L + STFM EM ET++I++ TNRS+ ++DE+G
Sbjct: 412 GCYVPARFATIRVVDRIFTRMGTMDNLESNSSTFMTEMRETAFIMQNVTNRSLIVMDELG 471
Query: 834 RGTSRSEGVAIAYATLKYLTTNNACRALFATHFGT--ELAS 872
R TS S+G+A+A++ +YL + A +FATH + ELA+
Sbjct: 472 RATSSSDGLAMAWSCCEYLLSLKA-YTVFATHMDSLAELAT 511
>Hs21361940 [L] KOG0221 Mismatch repair ATPase MSH5 (MutS family)
Length = 851
Score = 133 bits (334), Expect = 1e-30
Identities = 148/643 (23%), Positives = 278/643 (43%), Gaps = 83/643 (12%)
Query: 314 EIAALRNLLLYIEEH-----LPDINTNLELP--QKQLITDIMQIDSRTSTALEL-----H 361
++ AL LL ++ L D N ++ + +K ++T ++ ID T + L++ H
Sbjct: 196 QVRALGGLLKFLGRRRIGVELEDYNVSVPILGFKKFMLTHLVNIDQDTYSVLQIFKSESH 255
Query: 362 STMRKHH---KKG-SLLSTIRRTVTTSGTRLLTQWLSAPSMDINEIKNRQSLVLLF--KD 415
++ K K+G SL + R G +LL W + P+ D+ E+ +R ++ F
Sbjct: 256 PSVYKVASGLKEGLSLFGILNRCHCKWGEKLLRLWFTRPTHDLGELSSRLDVIQFFLLPQ 315
Query: 416 NFDYTESLIRYLKETADMSRIIQRFSFGRGDPLELIQIAKSLRKCKEISEYLQTNVHPST 475
N D + L R L ++ I++R H
Sbjct: 316 NLDMAQMLHRLLGHIKNVPLILKRMKLS----------------------------HTKV 347
Query: 476 KKTEKLIKNITKQLNFEDPIVEKVISSLNEESLIKQWSEKYERDDEEKFDASEENQERKS 535
+ L K + L D SL + S + RD ++F S++ S
Sbjct: 348 SDWQVLYKTVYSALGLRD-----ACRSLPQ-------SIQLFRDIAQEF--SDDLHHIAS 393
Query: 536 L---VMIMKPSASQKLKEYYKSYNILIKEKESLLQWYKDWFLE--RFKLKNVSLKQKNSG 590
L V+ + S ++ + + I EK+ L + E R +L+N+ + +
Sbjct: 394 LIGKVVDFEGSLAENRFTVLPNIDPEIDEKKRRLMGLPSFLTEVARKELENLDSRIPSCS 453
Query: 591 EFCIHLSGSIANVVEFDKYIEQQKDSSQAHSGFHVLQKSRQTRWIIHDKWETLSREIEVV 650
I L G + ++ +E S +G + S + + + L + +
Sbjct: 454 VIYIPLIGFLLSIPRLPSMVEA---SDFEINGLDFMFLSEEKLHYRSARTKELDALLGDL 510
Query: 651 GALIKNEEERLINQFQKDFISLSPMIRSLSQTLDYMDVLTSFAKLAIEQRLVLPKVT-QG 709
I+++E L+ Q Q ++ + ++ + +DVL + A A + P+ + Q
Sbjct: 511 HCEIRDQETLLMYQLQCQVLARAAVLTRVLDLASRLDVLLALASAARDYGYSRPRYSPQV 570
Query: 710 TELNIKGGRHLVVEASISQKSLESFTPN--DCQINSGELWVITGPNMGGKSTFLRQNAII 767
+ I+ GRH ++E +F PN +C + G + VITGPN GKS +L+Q +I
Sbjct: 571 LGVRIQNGRHPLMELCA-----RTFVPNSTECGGDKGRVKVITGPNSSGKSIYLKQVGLI 625
Query: 768 VILAQIGSFVPCESAVIGLVDKIFSRVGSADDLYNEMSTFMVEMIETSYILKGATNRSMA 827
+A +GSFVP E A IG VD IF+R+ S + + +STFM+++ + + + AT +S+
Sbjct: 626 TFMALVGSFVPAEEAEIGAVDAIFTRIHSCESISLGLSTFMIDLNQVAKAVNNATAQSLV 685
Query: 828 ILDEIGRGTSRSEGVAIAYATLK-YLTTNNACRALF-ATHFGTELASTINSTSNEEFINN 885
++DE G+GT+ +G+A+ A L+ +L C +F AT+F + + +
Sbjct: 686 LIDEFGKGTNTVDGLALLAAVLRHWLARGPTCPTVFVATNFLSLVQLQLLPQG-----PL 740
Query: 886 ISFFKTGIIGDNSNFYYDHKLKPGICSKSDAIKVAKLAGFPEE 928
+ + D ++ + +++ G+ S A A AG P++
Sbjct: 741 VQYLTMETCEDGNDLVFFYQVCEGVAKASHASHTAAQAGLPDK 783
>Hs4505253 [L] KOG0221 Mismatch repair ATPase MSH5 (MutS family)
Length = 834
Score = 132 bits (331), Expect = 3e-30
Identities = 148/642 (23%), Positives = 277/642 (43%), Gaps = 83/642 (12%)
Query: 315 IAALRNLLLYIEEH-----LPDINTNLELP--QKQLITDIMQIDSRTSTALEL-----HS 362
+ AL LL ++ L D N ++ + +K ++T ++ ID T + L++ H
Sbjct: 180 VRALGGLLKFLGRRRIGVELEDYNVSVPILGFKKFMLTHLVNIDQDTYSVLQIFKSESHP 239
Query: 363 TMRKHH---KKG-SLLSTIRRTVTTSGTRLLTQWLSAPSMDINEIKNRQSLVLLF--KDN 416
++ K K+G SL + R G +LL W + P+ D+ E+ +R ++ F N
Sbjct: 240 SVYKVASGLKEGLSLFGILNRCHCKWGEKLLRLWFTRPTHDLGELSSRLDVIQFFLLPQN 299
Query: 417 FDYTESLIRYLKETADMSRIIQRFSFGRGDPLELIQIAKSLRKCKEISEYLQTNVHPSTK 476
D + L R L ++ I++R H
Sbjct: 300 LDMAQMLHRLLGHIKNVPLILKRMKLS----------------------------HTKVS 331
Query: 477 KTEKLIKNITKQLNFEDPIVEKVISSLNEESLIKQWSEKYERDDEEKFDASEENQERKSL 536
+ L K + L D SL + S + RD ++F S++ SL
Sbjct: 332 DWQVLYKTVYSALGLRD-----ACRSLPQ-------SIQLFRDIAQEF--SDDLHHIASL 377
Query: 537 ---VMIMKPSASQKLKEYYKSYNILIKEKESLLQWYKDWFLE--RFKLKNVSLKQKNSGE 591
V+ + S ++ + + I EK+ L + E R +L+N+ + +
Sbjct: 378 IGKVVDFEGSLAENRFTVLPNIDPEIDEKKRRLMGLPSFLTEVARKELENLDSRIPSCSV 437
Query: 592 FCIHLSGSIANVVEFDKYIEQQKDSSQAHSGFHVLQKSRQTRWIIHDKWETLSREIEVVG 651
I L G + ++ +E S +G + S + + + L + +
Sbjct: 438 IYIPLIGFLLSIPRLPSMVEA---SDFEINGLDFMFLSEEKLHYRSARTKELDALLGDLH 494
Query: 652 ALIKNEEERLINQFQKDFISLSPMIRSLSQTLDYMDVLTSFAKLAIEQRLVLPKVT-QGT 710
I+++E L+ Q Q ++ + ++ + +DVL + A A + P+ + Q
Sbjct: 495 CEIRDQETLLMYQLQCQVLARAAVLTRVLDLASRLDVLLALASAARDYGYSRPRYSPQVL 554
Query: 711 ELNIKGGRHLVVEASISQKSLESFTPN--DCQINSGELWVITGPNMGGKSTFLRQNAIIV 768
+ I+ GRH ++E +F PN +C + G + VITGPN GKS +L+Q +I
Sbjct: 555 GVRIQNGRHPLMELCA-----RTFVPNSTECGGDKGRVKVITGPNSSGKSIYLKQVGLIT 609
Query: 769 ILAQIGSFVPCESAVIGLVDKIFSRVGSADDLYNEMSTFMVEMIETSYILKGATNRSMAI 828
+A +GSFVP E A IG VD IF+R+ S + + +STFM+++ + + + AT +S+ +
Sbjct: 610 FMALVGSFVPAEEAEIGAVDAIFTRIHSCESISLGLSTFMIDLNQVAKAVNNATAQSLVL 669
Query: 829 LDEIGRGTSRSEGVAIAYATLK-YLTTNNACRALF-ATHFGTELASTINSTSNEEFINNI 886
+DE G+GT+ +G+A+ A L+ +L C +F AT+F + + + +
Sbjct: 670 IDEFGKGTNTVDGLALLAAVLRHWLARGPTCPHIFVATNFLSLVQLQLLPQG-----PLV 724
Query: 887 SFFKTGIIGDNSNFYYDHKLKPGICSKSDAIKVAKLAGFPEE 928
+ D ++ + +++ G+ S A A AG P++
Sbjct: 725 QYLTMETCEDGNDLVFFYQVCEGVAKASHASHTAAQAGLPDK 766
>At3g20475 [L] KOG0221 Mismatch repair ATPase MSH5 (MutS family)
Length = 321
Score = 125 bits (313), Expect = 4e-28
Identities = 70/178 (39%), Positives = 112/178 (62%), Gaps = 9/178 (5%)
Query: 695 LAIEQRLVLPKVTQGTELNIKGGRHLVVEASISQKSLESFTPNDCQIN-SGELWVITGPN 753
LA + V P +T + L+I+ GRH++ E ++ ++F PND +IN +G + +ITGPN
Sbjct: 30 LAHQNNYVRPVLTVESLLDIRNGRHVLQEMAV-----DTFIPNDTEINDNGRIHIITGPN 84
Query: 754 MGGKSTFLRQNAIIVILAQIGSFVPCESAVIGLVDKIFSRVGSADDLYNEMSTFMVEMIE 813
GKS +++Q A+IV L+ IGSFVP ++A +GL D+IF +GS + E STFM+++ +
Sbjct: 85 YSGKSIYVKQVALIVFLSHIGSFVPADAATVGLTDRIFCAMGS-KFMTAEQSTFMIDLHQ 143
Query: 814 TSYILKGATNRSMAILDEIGRGTSRSEGVAIAYATLKYLTT-NNACRALFATHFGTEL 870
+L+ AT+RS+ +LDE G+GT +G+ + T+ + T R + TH TEL
Sbjct: 144 VGMMLRQATSRSLCLLDEFGKGTLTEDGIGLLGGTISHFATCAEPPRVVVCTHL-TEL 200
>YDL154w [L] KOG0221 Mismatch repair ATPase MSH5 (MutS family)
Length = 901
Score = 124 bits (310), Expect = 9e-28
Identities = 89/316 (28%), Positives = 157/316 (49%), Gaps = 33/316 (10%)
Query: 648 EVVGALIKNEEERLINQFQKDFISLSPMIRSLSQTLDYMDVLTSFAKLAIEQRLVLPKVT 707
++ GA+ E E L + Q+ + + + + L +++L SFA+++ E+ P++
Sbjct: 532 DIYGAISDFEIEILFS-LQEQILRRKTQLTAYNILLSELEILLSFAQVSAERNYAEPQLV 590
Query: 708 QGT-ELNIKGGRHLVVEASISQKSLESFTPND-------------CQINSGELWVITGPN 753
+ L I GRH + E L+++ PN C+ N G + V+TG N
Sbjct: 591 EDECILEIINGRHALYETF-----LDNYIPNSTMIDGGLFSELSWCEQNKGRIIVVTGAN 645
Query: 754 MGGKSTFLRQNAIIVILAQIGSFVPCESAVIGLVDKIFSRVGSADDLYNEMSTFMVEMIE 813
GKS +L QN +IV LAQIG FVP E A IG+ DKI +R+ + + +Y S+F+++ +
Sbjct: 646 ASGKSVYLTQNGLIVYLAQIGCFVPAERARIGIADKILTRIRTQETVYKTQSSFLLDSQQ 705
Query: 814 TSYILKGATNRSMAILDEIGRGTSRSEGVAIAYATLKYLTTNNAC-RALFATHFG---TE 869
+ L AT +S+ ++DE G+GT +G ++ + + ++ + C R + THF E
Sbjct: 706 MAKSLSLATEKSLILIDEYGKGTDILDGPSLFGSIMLNMSKSEKCPRIIACTHFHELFNE 765
Query: 870 LASTINSTSNEEFINNI------SFFKTGIIG---DNSNFYYDHKLKPGICSKSDAIKVA 920
T N + + +I + +T +G ++ + K+K GI +S I A
Sbjct: 766 NVLTENIKGIKHYCTDILISQKYNLLETAHVGEDHESEGITFLFKVKEGISKQSFGIYCA 825
Query: 921 KLAGFPEEALEIASTL 936
K+ G + +E A L
Sbjct: 826 KVCGLSRDIVERAEEL 841
>CE26678 [L] KOG0221 Mismatch repair ATPase MSH5 (MutS family)
Length = 1369
Score = 120 bits (300), Expect = 1e-26
Identities = 156/653 (23%), Positives = 275/653 (41%), Gaps = 94/653 (14%)
Query: 321 LLLYIEEH---LPDINTNLELPQKQLIT----DIMQIDSRTSTALEL---HSTMRKHHKK 370
LLL+++E + D ++ P K + T ++++ID T AL++ + +K +
Sbjct: 244 LLLFLDETRMGVTDDPLSVTSPIKSIKTFTLGNLVEIDFNTIQALDILPKETENKKTFGQ 303
Query: 371 G-SLLSTIRRTVTTSGTRLLTQWLSAPSMDINEIKNRQSLVLLFKD--NFDYTESLIRYL 427
G SL + + +T G + L +W P+ D +++ +RQ V FK N + T L L
Sbjct: 304 GRSLYQLMDKCRSTVGKKCLRKWFRNPTTDRDDLVSRQKCVHYFKQDWNAEVTAKLSSIL 363
Query: 428 KETADMSRIIQRFSFGRGDPLELIQIAKSLRKCKEISEYL-QTNVHPSTKKTEKLIKNIT 486
++ + Q+F G + ++ EI + QT + L++ ++
Sbjct: 364 GRVKALNSVFQKFQSGTAQLIHWECFVSTVNALVEILNIIRQTPISKEFPVESDLLREVS 423
Query: 487 KQLNFEDPIVEKVISSLNEESLIKQWSEKYERDDEEKFDASEENQERKSLVMIMKPSASQ 546
+ I+ S + + + E+ D + E +V+
Sbjct: 424 EIAVIAGSIINFAESKIQGRVTVMNGID-------EELDEIRDTYENMPMVL-------- 468
Query: 547 KLKEYYKSYNILIKEKESLLQWYKDWFLERFKLKNVSLKQKNSGEFCIHLSGSIANVVEF 606
+ K++E+ R L S N I L G + +V
Sbjct: 469 ---------TAIAKQEEA-----------RLGLPPYS----NVACVYIPLVGFVLSVPR- 503
Query: 607 DKYIEQQKDSSQAHSGFHVLQKSRQTRWIIHDKW-ETLSREIEVVGALIKNEEERLINQF 665
D +E Q D + +S L+ T + D++ + L R I+ A+I + R++ +
Sbjct: 504 DYGVESQPDMTLLYSTHEDLRVRNATTSRLDDEFGDILMRLIDSQTAIILTLKTRVMKKK 563
Query: 666 QKDFISLSPMIRSLSQTLDYMDVLTSFAKLAIEQRLVLPKVTQGTELNIKGGRHLVVEAS 725
+ LS R +DVL SF +A + P + + H +
Sbjct: 564 RSIIKLLSIASR--------IDVLISFGLIAAQNGWNCPALVDEPVIEAVELYHPISVLV 615
Query: 726 ISQKSLESFTPNDCQINSG----ELWVITGPNMGGKSTFLRQNAIIVILAQIGSFVPCES 781
+ + SF PN Q++SG + +ITGPN GKS +++ I+V L+ IGSFVP
Sbjct: 616 VKK----SFVPN--QVSSGRDGIKASIITGPNACGKSVYMKSIGIMVFLSHIGSFVPARH 669
Query: 782 AVIGLVDKIFSRVGSADDLYNEMSTFMVEMIETSYILKGATNRSMAILDEIGRGTSRSEG 841
A IG+VD+I +R+ + D + + MSTF ++ + + L+ AT S+ I+DE G+GT G
Sbjct: 670 AKIGIVDRIVTRMFTVDSVLDGMSTFAKDVEQVALALRKATGNSLVIIDEFGKGTMTEVG 729
Query: 842 VAIAYATLKYLTTNNA--CRALFATHFGTELASTINSTSNEEFINNISFFKTGII--GDN 897
+++ + + Y A C +F + L + I NI+ F T +
Sbjct: 730 LSLLASVMTYWMNRGADRCPHIFLSSHFHALPNYI------PLETNIATFLTFTVLREAG 783
Query: 898 SNFYYDHKLKPGICSKSDAIKVAKLAGFPE----------EALEIASTLLEEI 940
Y ++ PG+ S A+ VAK G P +AL+ A TLL+EI
Sbjct: 784 GKIKYLFRMTPGLVDCSFALSVAKEEGIPPPVIGRACRIYKALK-AGTLLKEI 835
>YFL003c [L] KOG0220 Mismatch repair ATPase MSH4 (MutS family)
Length = 878
Score = 107 bits (267), Expect = 9e-23
Identities = 167/696 (23%), Positives = 301/696 (42%), Gaps = 102/696 (14%)
Query: 210 DLNIPVGLSWCDISTGEIFVQ-----QVYLKDLVSSITRIRPMEVLLDEEIMPVEITNGE 264
D++ +GL + +TG++++ Q+Y++ +V + +P E+L+ + ++
Sbjct: 115 DISTRIGLCIINCNTGQMYLSDFMDSQIYIR-VVHKLQIYQPTEILIPSSSLAPTVS--- 170
Query: 265 WYKELTELKKYFIKYQKMPSKHRPIQSFFKLFSNAEG--DIGRSLGNFTQKEI------- 315
K T +K + K+ R K F++ +G I + L + T+K++
Sbjct: 171 --KLATMIKFNVAETVKIEEGSR------KCFNSQDGLAAITKYLMDDTKKDLKIEEIID 222
Query: 316 -----AALRNLLLYIEEHLPDINTNLELPQKQLIT-----DIMQIDSRTSTALELHSTMR 365
A + Y+EE + + NL +K I + M IDS+T LEL
Sbjct: 223 KTFALCAASAAISYMEEIISKSSRNLNAFRKLRIQFEGTENTMLIDSKTVRGLEL--VEN 280
Query: 366 KHHKKG-SLLSTIRRTVTTSGTRLLTQWLSAPSMDINEIKNRQSLVLLFKDNFDYTESLI 424
K K G SL + T T G R L + P D I+ R + K N D + L
Sbjct: 281 KLDKNGISLWKFLDTTSTKMGQRSLRNSILQPLTDRGSIEMRLEALEELKANDDLLQKLR 340
Query: 425 RYLKETADMSRIIQRFSFGRGDPLELIQIAKSLRKCKEISEYLQTNVHPSTKKTEKLIKN 484
+K D+ ++ R L+ I S K + Y+ K+T + +K+
Sbjct: 341 LEMKSLPDLDKLFSR----------LLCINHSAIKPDQRINYVLL-----LKETLQSVKS 385
Query: 485 ITKQLNFEDPIVEKVISSLNEESLIKQWSEKYERD---DEEKFDASEENQERKSLVMIMK 541
+ LN L + LI + + + D + EK S N++ +
Sbjct: 386 LKDALN----------DQLIQSRLISETKKIFNNDAIMEIEKLINSCINED-----CVWA 430
Query: 542 PSASQKLKEYYKSYNILIKEKESLL----QWYKDWFLERFK-LKNVSLKQKNSGEFCIHL 596
SA Q L + +SY + + LL Q YK+ E F+ +++++ K K I+L
Sbjct: 431 SSAIQLLNQ--RSYAVK-SDSNGLLDVSRQIYKEVKEEFFREVEDLTAKNK------INL 481
Query: 597 SGSIANVVEFDKYIEQQKDSSQAHSGFHV-LQKSRQTRWIIHDKWETLSREI---EVVGA 652
+ + F I++Q+ + + V + ++ + +I + + EV+
Sbjct: 482 DHNYDSARGFYLRIKRQEFTDDVATLPDVFISRTIKKNYIECTTLNIIKKNARLKEVMEE 541
Query: 653 LIKNEEERLINQFQKDFISLSPMIRSLSQTLDYMDVLTSFAKLAIEQRLVLPKVTQGTEL 712
++ EE + K +S + +++ + +D++ SF E +P T L
Sbjct: 542 ILLLSEETVDELLDKIATHISELFM-IAEAVAILDLVCSFTYNLKENNYTIPIFTNN--L 598
Query: 713 NIKGGRHLVVEASISQKSLESFTPNDCQI--NSGELWVITGPNMGGKSTFLRQNAIIVIL 770
I+ RH ++E K L++F PN +S L +ITG NM GKS +L+Q A+I I+
Sbjct: 599 LIRDSRHPLLE-----KVLKNFVPNTISSTKHSSSLQIITGCNMSGKSVYLKQVALICIM 653
Query: 771 AQIGSFVPCESAVIGLVDKIFSRVGSADDLYNEMSTFMVEMIETSYILKGATNRSMAILD 830
AQ+GS +P + ++ +RV + D + S F EM E +Y L ++ ILD
Sbjct: 654 AQMGSGIPALYGSFPVFKRLHARVCN-DSMELTSSNFGFEMKEMAYFLDDINTETLLILD 712
Query: 831 EIGRGTSRSEGVAIAYATLKYLTTNNACRALFATHF 866
E+GRG+S ++G ++ A ++L A +THF
Sbjct: 713 ELGRGSSIADGFCVSLAVTEHLLRTEA-TVFLSTHF 747
>At3g24320 [L] KOG0217 Mismatch repair ATPase MSH6 (MutS family)
Length = 1022
Score = 96.7 bits (239), Expect = 2e-19
Identities = 64/196 (32%), Positives = 97/196 (48%), Gaps = 8/196 (4%)
Query: 741 INSGELWVITGPNMGGKSTFLRQNAIIVILAQIGSFVPCESAVIGLVDKIFSRVGSADDL 800
++ L+++TGPN GGKS+ LR +L G VP ESA I D I + S D
Sbjct: 662 VDMQSLFLLTGPNGGGKSSLLRSICAAALLGISGLMVPAESACIPHFDSIMLHMKSYDSP 721
Query: 801 YNEMSTFMVEMIETSYILKGATNRSMAILDEIGRGTSRSEGVAIAYATLKYLTTNNACRA 860
+ S+F VEM E I+ AT+RS+ ++DEI RGT ++G IA + ++ L T + C
Sbjct: 722 VDGKSSFQVEMSEIRSIVSQATSRSLVLIDEICRGTETAKGTCIAGSVVESLDT-SGCLG 780
Query: 861 LFATHFGTELASTINSTSNEEFINNISFFKTGIIGDNSNFYYDHKLKPGICSKSDAIKVA 920
+ +TH + + + NI++ G KL G+C +S A + A
Sbjct: 781 IVSTHLHGIFSLPLTA-------KNITYKAMGAENVEGQTKPTWKLTDGVCRESLAFETA 833
Query: 921 KLAGFPEEALEIASTL 936
K G PE ++ A L
Sbjct: 834 KREGVPESVIQRAEAL 849
>At3g18525 [L] KOG0219 Mismatch repair ATPase MSH2 (MutS family)
Length = 422
Score = 60.5 bits (145), Expect = 1e-08
Identities = 37/122 (30%), Positives = 60/122 (48%), Gaps = 1/122 (0%)
Query: 344 ITDIMQIDSRTSTALELHSTMRKHHKKGSLLSTIRRTVTTS-GTRLLTQWLSAPSMDINE 402
I M++DS AL + + +K SL + RT T G RLL WL P +D+NE
Sbjct: 290 IGGFMRLDSAAMRALNVMESKTDANKNFSLFGLMNRTCTAGMGKRLLHMWLKQPLVDLNE 349
Query: 403 IKNRQSLVLLFKDNFDYTESLIRYLKETADMSRIIQRFSFGRGDPLELIQIAKSLRKCKE 462
IK R +V F + + L ++LK +D+ R+++ RG +I++ + L +
Sbjct: 350 IKTRLDIVQCFVEEAGLRQDLRQHLKRISDVERLLRSLERRRGGLQHIIKLYQVLSALQS 409
Query: 463 IS 464
S
Sbjct: 410 AS 411
>CE04858 [L] KOG0220 Mismatch repair ATPase MSH4 (MutS family)
Length = 107
Score = 50.8 bits (120), Expect = 1e-05
Identities = 33/95 (34%), Positives = 50/95 (51%), Gaps = 3/95 (3%)
Query: 794 VGSADDLYNEMSTFMVEMIETSYILKGATNRSMAILDEIGRGTSRSEGVAIAYATLKYLT 853
+G D+L S F EM + + I++ A S+ +LDE+ R TS EG+AI YA + +
Sbjct: 1 MGHNDELIRNKSAFASEMSDAAAIVQYADKNSLVVLDELARSTSTEEGIAITYAICEKVL 60
Query: 854 TNNACRALFATHF--GTELASTINSTSNEEFINNI 886
++ L ATHF LA+ N+ N F+ I
Sbjct: 61 KLHSYTFL-ATHFLDIAALANYSNAIDNYHFLPQI 94
>7294307 [L] KOG0217 Mismatch repair ATPase MSH6 (MutS family)
Length = 985
Score = 50.8 bits (120), Expect = 1e-05
Identities = 37/130 (28%), Positives = 68/130 (51%), Gaps = 18/130 (13%)
Query: 653 LIKNEEERLINQFQKDFISLSPMIRSLSQTLDYMDVLTSFAKLAIEQRLV-LPKVTQGTE 711
++K+ RL +F + I ++ +DVL S A+ A +Q ++ +P++ +
Sbjct: 864 VLKDLARRLFEKFSNHYDQWKQCIDCVAN----LDVLGSLAEYAGQQMVICVPELVSDAD 919
Query: 712 ---LNIKGGRHLVVEASISQKSLESFTPNDCQINSGE---LWVITGPNMGGKSTFLRQNA 765
+ ++ G H AS ++ PN ++ + L ++TGPNMGGKST +R+
Sbjct: 920 QPFIQLEEGYHPCANAS-------TYIPNGLELGTASEAPLSLLTGPNMGGKSTLMREVG 972
Query: 766 IIVILAQIGS 775
++VI+AQI S
Sbjct: 973 LLVIMAQIVS 982
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.318 0.134 0.374
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 53,293,987
Number of Sequences: 60738
Number of extensions: 2272068
Number of successful extensions: 8457
Number of sequences better than 1.0e-05: 30
Number of HSP's better than 0.0 without gapping: 26
Number of HSP's successfully gapped in prelim test: 4
Number of HSP's that attempted gapping in prelim test: 8365
Number of HSP's gapped (non-prelim): 61
length of query: 940
length of database: 30,389,216
effective HSP length: 116
effective length of query: 824
effective length of database: 23,343,608
effective search space: 19235132992
effective search space used: 19235132992
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)