ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactVI6505 good S KOG3680 Function unknown Uncharacterized conserved protein
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactVI6505 2264593 2261813 -927
(927 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YNL127w [S] KOG3680 Uncharacterized conserved protein 642 0.0
SPBC27B12.04c [S] KOG3680 Uncharacterized conserved protein 90 2e-17
CE04363 [S] KOG3680 Uncharacterized conserved protein 84 1e-15
Hs22040875 [S] KOG3680 Uncharacterized conserved protein 81 7e-15
Hs20543521 [S] KOG3680 Uncharacterized conserved protein 80 2e-14
7292353 [S] KOG3680 Uncharacterized conserved protein 73 2e-12
>YNL127w [S] KOG3680 Uncharacterized conserved protein
Length = 953
Score = 642 bits (1657), Expect = 0.0
Identities = 365/871 (41%), Positives = 524/871 (59%), Gaps = 65/871 (7%)
Query: 75 DRQSNEANNSSEIIDTQDDAN-GEEDDEDSEFANVDEIDXXXXXXXXXXXLKDYFQGYDS 133
DR + + NN+ ++ QDDA EE++ED FANVDE+D G+D
Sbjct: 126 DRNNEKDNNTDNAVEFQDDAEEAEEENEDESFANVDELD-----------------GFD- 167
Query: 134 YTNGQASPKQLRKVSPELNDKDKIITYEDVKVEEDNNLPVDDALKKLLQEKADEIERGDL 193
L KVS D + E K E D N+PVD +K L + A +E
Sbjct: 168 ----------LNKVS----DGKHVPINE--KGEVDYNMPVDKEFQKSLDQCAASLEERSS 211
Query: 194 SHSFTKPTLDWQASDFNSLFHELSEWFIQKDYGSL-KTAKLSFEKNYDSSKFIEERKYAI 252
+ + +DW+ F SL ELSEWF DY +T L +K F ++ YA
Sbjct: 212 APYALQRAVDWELKMFYSLEDELSEWFCSSDYMHFGQTQTLFKQKITQPQLFFDDENYAA 271
Query: 253 QVITELGKKLEVNSVDINTLLCLAYISFGTFQETNSYFHHLDILRRNNTLLMMISKVLLP 312
V+ L + + NS+ N LL L+YIS G F TNS H I+RRNN +L+ + ++
Sbjct: 272 SVVECLIEDIP-NSLASN-LLALSYISMGCFAFTNSKSEHTKIIRRNNLMLVPHIQEIVH 329
Query: 313 CFKKHADCCRVKNTNLQQYNTLLFYSGSITYFMINIAIEQRSMHTKAVEDFIDVVHSSGL 372
FKK A CR N NL++ LLF+S +I YF+ +I IE R + +AV ID + L
Sbjct: 330 AFKKIAISCRDDNRNLKKQTILLFHSSTILYFICSICIEGRGENPEAVNVVIDAFEKTDL 389
Query: 373 MLFLTKYIDHWRWKSRLSMRIRNIIILFHKVLLLQFGEESHYDAVKRFVLQHHKIEKKDS 432
+ FLTKYI++WRW SRL+MRIRN+I L K+++LQFG+ S Y K + H +
Sbjct: 390 LEFLTKYIENWRWNSRLAMRIRNMISLLFKLIVLQFGDSSVYKQTKSSIYNLHGLTYPSK 449
Query: 433 SASNLSISPLEYVAFREDITSRFPSSQLPEPTYPSMLDNPNSLSQFLEIXXXXXXXXXNM 492
LSISPL Y AFREDITSRFP +P P +D SLSQFLEI NM
Sbjct: 450 HPEKLSISPLHYQAFREDITSRFPDYNMPSSGLPKDVDKSESLSQFLEIPRPKSKNPLNM 509
Query: 493 SLGEPQVHMXXXXXX--XXXXXXXXXNGLKTRKSFQANLSYPAFFPSSGDYDTGVVDELS 550
+L P+ H+ G + RKSFQ N++YP +PS D + D L
Sbjct: 510 ALIVPEKHIATPAPSPPSSPQLMHLGEGPRPRKSFQTNMAYPCLYPS--DNEGSEDDTLE 567
Query: 551 NKLSIAVP-----ETVLPYNMQEAIEILSKSVHIKLSTKQLWHERELFMVQERGWTNTEV 605
+++ + + + V+P++ +EA ILS+S+ IKLSTKQLW+ER+LFM+ ERGW +
Sbjct: 568 DRIDLNIERKPDNDIVIPFSTEEAARILSESLEIKLSTKQLWYERDLFMITERGW--KQQ 625
Query: 606 HEKDPFTYRGIQNEEPET---------MNRIEDYYANALPHFSSLVYVLLETIETCMSNK 656
E +P+ Y + ++ + M RI+ YY + L F+SLV+VLL+T+E+ ++N
Sbjct: 626 LENEPYDYAALNHDANSSKEEKSAICIMQRIDKYYKSCLSSFNSLVFVLLQTMESSLTNN 685
Query: 657 VYLEEDFSEEE-INELQPQLELIRSKEIAMESSSAILFLLLKWFKVSHFLKFEYLCSLIY 715
+ + + S++ +N L PQLE++R+KE++++S++ IL LLKWFK+SH LKFE+L +I+
Sbjct: 686 FHRKSEVSDKNLLNMLTPQLEIVRAKELSLKSAAGILHALLKWFKLSHILKFEHLAVVIH 745
Query: 716 DSKFITTSVGILQSFTDQYQNRIYSKHLQPTHSFWSECSLYNVQYKETLEISTANEKANR 775
DS++I T IL +++ Y R+++K++Q +SFW ECSL N Y+E+ + + E
Sbjct: 746 DSRYINTCASILSKYSEVYPERVFNKYVQTPNSFWKECSLSNESYRESYSVDDSGE---- 801
Query: 776 LNLRMLNSEVYLLRVLSKITGKKTQRLKDLPLNVSNIFKALYSIFNLDIYHPILKIIHEL 835
++ ++ S YLLR+L K+TG KTQRLK+LPL++ +FK Y +FNLD+YHPILKI EL
Sbjct: 802 VDTEIMPSFAYLLRILRKVTGNKTQRLKELPLSIGILFKRYYRLFNLDMYHPILKITREL 861
Query: 836 APFKNKRWRADHMELISGVFLHEKLHLTDNWITGKDITGEINDSYGQEIALRAMLQFYNF 895
PFKNKRW+++HMELISGV+L+EKL LTDNW+TGKDI+GE++D+ GQEIALRA+LQFYNF
Sbjct: 862 TPFKNKRWKSEHMELISGVYLYEKLELTDNWVTGKDISGELSDACGQEIALRALLQFYNF 921
Query: 896 YHYKRTMEHCGYDDKFSNS--FFSREAELLS 924
HY+ +ME GY + S+S ++E+E L+
Sbjct: 922 QHYEISMEDLGYGHRNSSSQDLLNKESEYLN 952
>SPBC27B12.04c [S] KOG3680 Uncharacterized conserved protein
Length = 817
Score = 89.7 bits (221), Expect = 2e-17
Identities = 162/803 (20%), Positives = 311/803 (38%), Gaps = 147/803 (18%)
Query: 177 LKKLLQEKADEIERGDLSHSFTKPTLDWQASDFNSLFHELSEWFIQKD---YGSLKTAKL 233
LKKL+ A + + + F + D D NS F E F+ + Y L+ +
Sbjct: 17 LKKLIDSPASKHKPME----FKGTSKDDLEDDLNSFFDCEEELFLSANKIFYSKLRVYQT 72
Query: 234 ----SFEKNYDSSKFIEERKYAIQVITELGK-KLEVNSVDINTLLCLAYISFGTFQETNS 288
S ++N+ S ++R + + EL +L NS L + YI+ G + S
Sbjct: 73 VRHWSLKQNWSSMSLDQKRNFILHCHHELSSGELLRNSA----LYSILYIAAGAYDSVGS 128
Query: 289 YFHHLDILRRNNTLLMM--ISKVLLPCF------KKHADCCRVKNTNLQQYNTLLFYSGS 340
+ H+ + N LL I K + F +KH+ + N+ + + LL S
Sbjct: 129 FEEHVHSISENVYLLREFDIPKTVYSLFIEWNRTRKHSF---LDNSRDEGFLNLLL---S 182
Query: 341 ITYFMINIAIEQRS-MHT----------KAVEDFIDVVHSSGLMLFLTKYIDHWRWKSRL 389
+ +F + + ++ +H+ V+ FID+ +S L L K I
Sbjct: 183 LMFFFLTLNNTDKTWIHSIRSLNPPVLPTLVKLFIDI--TSDYQLNLDKVIHS------- 233
Query: 390 SMRIRNIIILFHKVLLLQFGEESHYDAVKRFVLQHHKIEKKDSSASNLSISPLEYVAFRE 449
++ + L KV + +G +S+ K + + I +S + L+Y FR
Sbjct: 234 --SLKKLSFLIFKVCIRLWGSQSYLQEKKAGLAEVLNIS---TSQQKPKTTALDYEVFRH 288
Query: 450 DITSRFPSSQLPEPTYPSMLDNPNSLSQFLEIXXXXXXXXXNMSLGEPQVHMXXXXXXXX 509
++ ++F S + YP LD + I + S +
Sbjct: 289 EMATKF--SSFADSYYPVPLDREQA-----HILPTLNTDSFHKSSFISSTRLCSPENPSL 341
Query: 510 XXXXXXXNGLKTRKS-FQANLSYPAFFPSSGDYDTGVVDELSNKLSIAVPETVLPYNMQE 568
+ + R+ FQ N + P F + + + +PY++ E
Sbjct: 342 LVNTAKTSKMSARREQFQTNQNLPFCFTPN------------------LEKLTIPYSVTE 383
Query: 569 AIEILSKSVHIKLSTKQLWHEREL---FMVQERGWTNTEVHE-----KDPFTYRGIQNEE 620
A + L+ +QL EREL F +Q+R ++HE K P + E+
Sbjct: 384 AANVFQNKTKRTLAVEQLLSERELLRRFTLQQR--LVADLHEFYNSVKGPA--HSFETED 439
Query: 621 PETMNRIEDYYANALPHFSSLVYVLLET------------IETCMSNKVYLE-------- 660
P + + Y + P+ + + + ++ +E S+ L+
Sbjct: 440 P-VLKFVSQSYDDLFPYMDNFIQLAVQLFYHISKKVNCLYVEAFSSSDAVLQRIQDNAVV 498
Query: 661 ----EDFSEEEINELQPQLEL-------------------IRSKEIAMESSSAILFLLLK 697
E+ SE+ + +++ I + E + S S++ ++LK
Sbjct: 499 DSPTEELSEQAARNRKSNVKIEYTEDFATGFAISGEISHSINNLEFVLYSLSSLFLMMLK 558
Query: 698 WFKVSHFLKFEYLCSLIYDSKFITTSVGILQSFTDQYQNRIYSKHLQPTH-SFWSECSLY 756
WF++SH L+FE L L+Y++ F+ + T+ NR K ++ F+S S
Sbjct: 559 WFRLSHVLRFERLAFLLYENHFLEI---FNRHLTEGDCNRNTEKDVKCVRGGFFSYSSKM 615
Query: 757 NVQYKETLEISTANEKANRLNLRMLNSEVYLLRVLSKITGKKTQRLKDLP-LNVSNIFKA 815
+ ++ + T + L + M LRVL K+ R + + N+ K
Sbjct: 616 YKYDRVSIPVITRASSSRNLLITM-----NCLRVLEKVCKYSNIRKEIIARSNLHENLKK 670
Query: 816 LYSIFNLDIYHPILKIIHELAPFKNKRWRADHMELISGVFLHEKLHLTDNWITGKDITGE 875
L +I + + LK++ PF +W+ +M +I+ ++L+ L L D+W+ ++ +
Sbjct: 671 LLAIPHDKLRLYALKVLKLSVPFLGLKWKQANMSIITQIYLNCSLDLRDSWMFHENGSDT 730
Query: 876 INDSYGQEIALRAMLQFYNFYHY 898
+ QE L +++FY+ Y
Sbjct: 731 YRSAQLQETFLAILIRFYHIRLY 753
>CE04363 [S] KOG3680 Uncharacterized conserved protein
Length = 929
Score = 83.6 bits (205), Expect = 1e-15
Identities = 84/364 (23%), Positives = 162/364 (44%), Gaps = 42/364 (11%)
Query: 562 LPYNMQEAIEILSKSVHIKLSTKQLWHEREL-----FMVQERGWTNTEVHEKDPFTYRGI 616
LP + A++IL +++ L+ Q+ + EL M ++ T TE YR I
Sbjct: 497 LPPSFCGAVKILRNNMYTSLTELQVKKDEELNRYLFSMKEDIPETKTET------LYRKI 550
Query: 617 QNEEPETMNRIEDYYANALPHFSS-------LVYVLLETIETC--MSNKVYLEEDFSEEE 667
+ + + +++P + L+ L +E +SN + L+ S
Sbjct: 551 LPNLSQYICALVKVMVSSVPSTKARHEGLNVLIDCLTPEMEASDILSNSISLDNSTSSPL 610
Query: 668 INELQPQLELIRSKEIAMESSSAILFLLLKWFKVSHFLKFEYLCSLIYDSKFITTSVGIL 727
+ +++ R KEI ++S SAIL LL+K FK++H +FEY+C I + ++
Sbjct: 611 EEGFRLAIDINRHKEIIVKSLSAILLLLVKHFKLNHIYQFEYICQQI----VYVNGIPLI 666
Query: 728 QSFTDQYQNRIYSKHLQPTHSFWSECSLYNVQYKETLEISTANE--------KANRLNLR 779
F DQ N++ + + +C + V+ E I T + R
Sbjct: 667 LKFLDQNTNKLIQSRHEIYAYNYPQCLYHYVRNNEEWPILTQDNIEEPRPPGAGPYFMWR 726
Query: 780 MLNSEVYLLRVLSKITGKKTQRLKDLPLNVS-----NIFKALYSIFNLDIYHPILKIIHE 834
+ + L+R+L+K+ K R+K L + S +FK S+ L +Y +LK I
Sbjct: 727 NVFFAINLIRLLNKLVKAKNDRVKMLMVFKSAPVLKRLFKVRVSV--LQLY--VLKAIKM 782
Query: 835 LAPFKNKRWRADHMELISGVFLHEKLHLTDNWITGKDITGEINDSYGQEIALRAMLQFYN 894
+ + ++WR +M++IS ++ + +TD+W DI + D ++ ++A ++ ++
Sbjct: 783 QSRYLGRQWRKSNMDIISAIYSRVRHRMTDDWAFASDIKRKC-DYQKEDSLIKASIERFH 841
Query: 895 FYHY 898
Y
Sbjct: 842 SRRY 845
>Hs22040875 [S] KOG3680 Uncharacterized conserved protein
Length = 742
Score = 81.3 bits (199), Expect = 7e-15
Identities = 64/243 (26%), Positives = 119/243 (48%), Gaps = 7/243 (2%)
Query: 659 LEEDFSEEEINELQPQLELIRSKEIAMESSSAILFLLLKWFKVSHFLKFEYLCSLIYDSK 718
L E+ + ++ +++ R KE+ +++ SA+L LLLK FK++H +FEY+ + +
Sbjct: 454 LPEEMPTTVLQSMKLGVDVNRHKEVIVKAISAVLLLLLKHFKLNHVYQFEYMAQHLVFAN 513
Query: 719 FITTSVGILQSFTDQYQNRIYSKHLQPTHSFWSECSLYNVQYKETLEISTANEKANRLNL 778
I IL+ F + I +K+ + C ++ + + T E A + +N+
Sbjct: 514 CIPL---ILKFFNQNIMSYITAKNSISVLDY-PHCVVHELP-ELTAESLEAGD-SNQFCW 567
Query: 779 RMLNSEVYLLRVLSKITGKKTQRLKDLPLNVSN-IFKALYSIFNLDIYHPILKIIHELAP 837
R L S + LLR+L+K+T K R L + S I K + + +LK++
Sbjct: 568 RNLFSCINLLRILNKLTKWKHSRTMMLVVFKSAPILKRALKVKQAMMQLYVLKLLKVQTK 627
Query: 838 FKNKRWRADHMELISGVFLHEKLHLTDNWITGKDITGEINDSYGQEIALRAMLQFYNFYH 897
+ ++WR +M+ +S ++ + L D+W G D+ D +E ALRA ++ +N
Sbjct: 628 YLGRQWRKSNMKTMSAIYQKVRHRLNDDWAYGNDLDARPWDFQAEECALRANIERFNARR 687
Query: 898 YKR 900
Y R
Sbjct: 688 YDR 690
>Hs20543521 [S] KOG3680 Uncharacterized conserved protein
Length = 834
Score = 79.7 bits (195), Expect = 2e-14
Identities = 84/352 (23%), Positives = 159/352 (44%), Gaps = 32/352 (9%)
Query: 562 LPYNMQEAIEILSKSVHIKLSTKQLWHERELFMVQERGWTNTEVHEKDPFTYRGIQNEEP 621
LP + E+++ L + +I ++ Q+ +E EL EK P + + P
Sbjct: 455 LPRPIHESVKTLKQHKYISIADVQIKNEEEL--------------EKCPMSLG--EEVVP 498
Query: 622 ETMNRI-EDYYANALPHFS-SLVYVLLETIET--CMSNKVYLEEDFSEEE-----INELQ 672
ET I +LP + +L+ +LL T ++ + + D EE + ++
Sbjct: 499 ETPCEILYQGMLYSLPQYMIALLKILLAAAPTSKAKTDSINILADVLPEEMPITVLQSMK 558
Query: 673 PQLELIRSKEIAMESSSAILFLLLKWFKVSHFLKFEYLCSLIYDSKFITTSVGILQSFTD 732
+++ R KEI ++S S +L LLLK FK++H +FEY+ + + I IL+ F
Sbjct: 559 LGIDVNRHKEIIVKSISTLLLLLLKHFKLNHIYQFEYVSQHLVFANCIPL---ILKFFNQ 615
Query: 733 QYQNRIYSKHLQPTHSFWSECSLYNVQYKETLEISTANEKANRLNLRMLNSEVYLLRVLS 792
+ I +K+ + C++ ++ T + + ++ R L S + LLR+L+
Sbjct: 616 NILSYITAKNSISVLDYPC-CTIQDLPELTTESLEAGDN--SQFCWRNLFSCINLLRLLN 672
Query: 793 KITGKKTQRLKDLPLNVSN-IFKALYSIFNLDIYHPILKIIHELAPFKNKRWRADHMELI 851
K+T K R L + S I K + + +LK++ + ++WR +M+ +
Sbjct: 673 KLTKWKHSRTMMLVVFKSAPILKRALKVKQAMLQLYVLKLLKLQTKYLGRQWRKSNMKTM 732
Query: 852 SGVFLHEKLHLTDNWITGKDITGEINDSYGQEIALRAMLQFYNFYHYKRTME 903
S ++ + + D+W G DI D +E LRA ++ +N Y R +
Sbjct: 733 SAIYQKVRHRMNDDWAYGNDIDARPWDFQAEECTLRANIEAFNSRRYDRPQD 784
>7292353 [S] KOG3680 Uncharacterized conserved protein
Length = 882
Score = 73.2 bits (178), Expect = 2e-12
Identities = 57/234 (24%), Positives = 109/234 (46%), Gaps = 6/234 (2%)
Query: 675 LELIRSKEIAMESSSAILFLLLKWFKVSHFLKFEYLCSLIYDSKFITTSVGILQSFTDQY 734
+++ R KEI +++ SAI+ L LK FK++H +FE++ + + I +L+ F
Sbjct: 542 VDIGRHKEIIVKAVSAIILLYLKHFKINHVYQFEFMSQHLVFANCIPL---VLKFFNQTI 598
Query: 735 QNRIYSKHLQPTHSFWSECSLYNVQYKETLEISTANEKANR-LNLRMLNSEVYLLRVLSK 793
+ +K+ P F S C + E +++ + R + S + LLR+L+K
Sbjct: 599 TEYVNTKNSIPLLDFPS-CVIGEQPDLSGDSFVYGGEMSDKSYSWRNVFSCINLLRILNK 657
Query: 794 ITGKKTQRLKDLPLNVSN-IFKALYSIFNLDIYHPILKIIHELAPFKNKRWRADHMELIS 852
+ K R+ L + S I K + + + +LK++ + ++WR +M+ +S
Sbjct: 658 LIKWKHSRVMMLVVFKSAPILKKTLKVRHAMMQLYVLKLLKMQTKYLGRQWRKSNMKTMS 717
Query: 853 GVFLHEKLHLTDNWITGKDITGEINDSYGQEIALRAMLQFYNFYHYKRTMEHCG 906
++ + L D+W G D+ D +E LRA + +N Y + CG
Sbjct: 718 AIYAKVRHRLNDDWAFGNDLESRPWDFQAEECTLRACVDRFNLRRYPEATQKCG 771
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.318 0.134 0.386
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 51,970,197
Number of Sequences: 60738
Number of extensions: 2217825
Number of successful extensions: 9004
Number of sequences better than 1.0e-05: 6
Number of HSP's better than 0.0 without gapping: 1
Number of HSP's successfully gapped in prelim test: 5
Number of HSP's that attempted gapping in prelim test: 8985
Number of HSP's gapped (non-prelim): 11
length of query: 927
length of database: 30,389,216
effective HSP length: 116
effective length of query: 811
effective length of database: 23,343,608
effective search space: 18931666088
effective search space used: 18931666088
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)