ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactVI6628 good A KOG1919 RNA processing and modification RNA pseudouridylate synthases
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactVI6628 2306055 2307845 597
(597 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YOL066c_1 [A] KOG1919 RNA pseudouridylate synthases 592 e-169
YDL036c [A] KOG1919 RNA pseudouridylate synthases 536 e-152
SPAC18B11.02c [A] KOG1919 RNA pseudouridylate synthases 370 e-102
Hs17478211 [A] KOG1919 RNA pseudouridylate synthases 264 3e-70
7297709 [A] KOG1919 RNA pseudouridylate synthases 263 7e-70
7297707 [A] KOG1919 RNA pseudouridylate synthases 251 3e-66
CE11898 [A] KOG1919 RNA pseudouridylate synthases 218 2e-56
At5g51140 [A] KOG1919 RNA pseudouridylate synthases 216 8e-56
YOL066c_2 [F] KOG1018 Cytosine deaminase FCY1 and related enzymes 211 2e-54
YGR169c [A] KOG1919 RNA pseudouridylate synthases 206 6e-53
ECU05g0680 [A] KOG1919 RNA pseudouridylate synthases 162 1e-39
SPCC4G3.16 [F] KOG1018 Cytosine deaminase FCY1 and related enzymes 124 3e-28
At3g52260 [A] KOG1919 RNA pseudouridylate synthases 80 1e-14
Hs20481524 [A] KOG1919 RNA pseudouridylate synthases 75 4e-13
Hs14249470 [A] KOG1919 RNA pseudouridylate synthases 75 4e-13
Hs17158025 [A] KOG1919 RNA pseudouridylate synthases 64 7e-10
At1g76050 [A] KOG1919 RNA pseudouridylate synthases 61 6e-09
At3g19440 [A] KOG1919 RNA pseudouridylate synthases 52 2e-06
>YOL066c_1 [A] KOG1919 RNA pseudouridylate synthases
Length = 434
Score = 592 bits (1526), Expect = e-169
Identities = 268/390 (68%), Positives = 330/390 (83%), Gaps = 1/390 (0%)
Query: 56 MRDKQGFQLKIQDVNGSRNKQTDPDYDVKIEGALRKIVPYFFTYKTFCKERWRDRKLIDI 115
++D GF+L++ +G + K+TDPDY+V I+G LRKI PYFFTYKTFCKERWRDRKL+D+
Sbjct: 45 VKDASGFRLRVIQTDGHKTKKTDPDYEVTIDGPLRKIEPYFFTYKTFCKERWRDRKLVDV 104
Query: 116 FIDEFRDRSPEYYRKTIAAGKVYLNDSVADLDSVVRNGDLITHEIHRHEPSVTSRLIKTV 175
F+ EFRDR P YY KTIA GKVYLND A+LD+++R+GDLITH++HRHEP VTS+ I V
Sbjct: 105 FVSEFRDREPSYYSKTIAEGKVYLNDEPANLDTIIRDGDLITHKVHRHEPPVTSKPIDIV 164
Query: 176 FEDDDLLVIDKPSGIPVHPTGRYRFNTVTKILEKERGYTVHPCNRLDRLTSGLMFLAKNP 235
FED+D+LVIDKPS IPVHPTGRYRFNT+TK+LE++ GY+VHPCNRLD+ TSGLMFLAK P
Sbjct: 165 FEDEDILVIDKPSSIPVHPTGRYRFNTITKMLERQLGYSVHPCNRLDKPTSGLMFLAKTP 224
Query: 236 RGADRMADQMKAREVSKEYVARVVGEFPVGLIVVDKPLRTVDPKVGLNVTCKITDEGAKE 295
GADRM DQMKAREV+KEYVARV GEFP+G++ VDKP+R+V+PKV LN C+++DE AK
Sbjct: 225 LGADRMGDQMKAREVTKEYVARVKGEFPIGIVEVDKPVRSVNPKVALNAVCEMSDENAKH 284
Query: 296 ARTSFERISFDGKTSIVRCKPFTGRTHQIRVHLQHLGHPIANDPIYSNPHIWGPSLGKDY 355
A+T F+R+S+DG+TSIV+CKP TGRTHQIRVHLQ+LG PIANDPIYSNP IWGP LG+
Sbjct: 285 AKTVFQRVSYDGQTSIVKCKPLTGRTHQIRVHLQYLGFPIANDPIYSNPDIWGPDLGRGG 344
Query: 356 EGDFSDIIGSLDLVGKTESAESWMHPDSFGEVLLGQQCEICDTELYSDPGPNDLDLWLHA 415
++ DI+ LD +GKT AESW+HP S GE LLG+QCE C+ E+Y+DPG NDLDLWLHA
Sbjct: 345 LQNYDDIVLKLDAIGKTNPAESWIHPHSEGEYLLGRQCEECEAEMYTDPGTNDLDLWLHA 404
Query: 416 YRYESTELDSDGKK-LWSYRTDFPDWAIEP 444
+RYES E +SD +K LWSYRT +P+WA+EP
Sbjct: 405 FRYESLERNSDTQKPLWSYRTKYPEWALEP 434
>YDL036c [A] KOG1919 RNA pseudouridylate synthases
Length = 462
Score = 536 bits (1380), Expect = e-152
Identities = 240/387 (62%), Positives = 313/387 (80%), Gaps = 2/387 (0%)
Query: 58 DKQGFQLKIQDVNGSRNKQTDPDYDVKIEGALRKIVPYFFTYKTFCKERWRDRKLIDIFI 117
+K FQ + +++Q DP+Y++ I+G LRKI PY FTY+TFCKERWRD+KL+D+FI
Sbjct: 74 NKSTFQSRTIGSKKEKHRQLDPEYEIVIDGPLRKIKPYHFTYRTFCKERWRDKKLVDVFI 133
Query: 118 DEFRDRSPEYYRKTIAAGKVYLNDSVADLDSVVRNGDLITHEIHRHEPSVTSRLIKTVFE 177
EFRDR EYY++TI G V++ND ADL +V+RNGDLITH++HRHEP VTSR IK +FE
Sbjct: 134 SEFRDRESEYYKRTIENGDVHINDETADLSTVIRNGDLITHQVHRHEPPVTSRPIKVIFE 193
Query: 178 DDDLLVIDKPSGIPVHPTGRYRFNTVTKILEKERGYTVHPCNRLDRLTSGLMFLAKNPRG 237
DD+++VIDKPSGIPVHPTGRYRFNT+TK+L+ G+ V+PCNRLDRLTSGLMFLAK P+G
Sbjct: 194 DDNIMVIDKPSGIPVHPTGRYRFNTITKMLQNNLGFVVNPCNRLDRLTSGLMFLAKTPKG 253
Query: 238 ADRMADQMKAREVSKEYVARVVGEFPVGLIVVDKPLRTVDPKVGLNVTCKITDEGAKEAR 297
AD + DQ+KAREV+KEYVA+VVGEFP ++V+KPL+ ++P++ LN C++ ++GAK A+
Sbjct: 254 ADNIGDQLKAREVTKEYVAKVVGEFPETEVIVEKPLKLIEPRLALNAVCQMDEKGAKHAK 313
Query: 298 TSFERISFDGKTSIVRCKPFTGRTHQIRVHLQHLGHPIANDPIYSNPHIWGPSLGKDYEG 357
T F RIS+DGKTSIV+CKP TGR+HQIRVHLQ+LGHPIANDPIYSN +WG +LGK +
Sbjct: 314 TVFNRISYDGKTSIVKCKPLTGRSHQIRVHLQYLGHPIANDPIYSNDEVWGNNLGKGGQA 373
Query: 358 DFSDIIGSLDLVGKTESAESWMHPD-SFGEVLLGQQCEICDTELYSDPGPNDLDLWLHAY 416
DF +I LD +GK + A+SW H + +GEVL ++C IC+++LY+DPGPNDLDLWLHAY
Sbjct: 374 DFDIVITKLDEIGKRKPAKSWFHSNGGYGEVLRQEKCSICESDLYTDPGPNDLDLWLHAY 433
Query: 417 RYESTEL-DSDGKKLWSYRTDFPDWAI 442
YESTE + KK W Y+T++P+WA+
Sbjct: 434 LYESTETEEGTEKKKWCYKTEYPEWAL 460
>SPAC18B11.02c [A] KOG1919 RNA pseudouridylate synthases
Length = 394
Score = 370 bits (951), Expect = e-102
Identities = 189/389 (48%), Positives = 257/389 (65%), Gaps = 31/389 (7%)
Query: 73 RNKQTDPDYDVKIEGALRKIVPYFFTYKTFCKERWRDRKLIDIFIDEFRDRSPEYYRKTI 132
R+ D +Y K +G LR++ PY++ Y TF K RW + L+++F EFRDR YY K I
Sbjct: 7 RDPLKDCEYVFKGDG-LRRVPPYYYEYITFAKLRWYGKTLLEVFNTEFRDRESGYYEKAI 65
Query: 133 AAGKVYLNDSVADLDSVVRNGDLITHEIHRHEPSVTSRLIKTVFEDDDLLVIDKPSGIPV 192
G+V +N+ + ++D+++ NG +++H HRHEP V+ + + V ED+ +VIDKP+G+PV
Sbjct: 66 RNGQVKVNNQIGNVDTLIENGYIVSHHAHRHEPPVSDQPVGIVHEDESYVVIDKPAGVPV 125
Query: 193 HPTGRYRFNTVTKILEKERGYT-VHPCNRLDRLTSGLMFLAKNPRGADRMADQMKAREVS 251
HPTGRY NTV IL KE + ++PCNRLDRLTSGLMF +K+P+ A+ M M ++ +
Sbjct: 126 HPTGRYNHNTVLHILMKENKCSLLYPCNRLDRLTSGLMFFSKSPKAAEEMRVHMISKSLK 185
Query: 252 KEYVARVVGEFP-VGLIVVDKPLRTVDPKVGLNVTCKITDEGAKEARTSFERISFDGKTS 310
KEYVARV+GEFP G ++ D PL TV P +GLN +I +G KEA T F+RI+FDG TS
Sbjct: 186 KEYVARVIGEFPNSGEVICDAPLLTVAPTLGLN---RIHPDG-KEASTVFKRIAFDGHTS 241
Query: 311 IVRCKPFTGRTHQIRVHLQHLGHPIANDPIYSNPHIWGPSLGKDYEGDFSDIIGSLDLVG 370
+V CKP TGRTHQ+RVHLQ+LG+PIANDPIY+N +WGPSLGK+ EG +I L +G
Sbjct: 242 LVLCKPLTGRTHQLRVHLQYLGYPIANDPIYANKRVWGPSLGKNGEGSNESVIMRLSEIG 301
Query: 371 KTESAE-----SWMHPDS-----------FGEVLLGQQCEICDTELYSDPGPNDLDLWLH 414
KTE+A W ++ GE+L G+ C C T LYSDP P +L +WLH
Sbjct: 302 KTETASPLLQYEWYTNETEAEAKARRDKRLGELLTGKHCSECGTPLYSDPSPEELGIWLH 361
Query: 415 AYRYESTELDSDGKKLWSYRTDFPDWAIE 443
A +YES K WSY+T P WA++
Sbjct: 362 ALKYES--------KDWSYKTQLPKWALD 382
>Hs17478211 [A] KOG1919 RNA pseudouridylate synthases
Length = 545
Score = 264 bits (674), Expect = 3e-70
Identities = 130/270 (48%), Positives = 185/270 (68%), Gaps = 7/270 (2%)
Query: 86 EGALRKIVPYFFTYKTFCKERWRDRKLIDIFIDEFRDRSPEYYRKTIAAGKVYLNDS-VA 144
EG LRK+ PY+F ++T+CK RW L+ +F EFR + YY + AG++ LN+ V
Sbjct: 136 EGGLRKVRPYYFDFRTYCKGRWVGHSLLHVFSTEFRAQPLAYYEAAVRAGRLQLNEKPVQ 195
Query: 145 DLDSVVRNGDLITHEIHRHEPSVTSRLIKTVFEDDDLLVIDKPSGIPVHPTGRYRFNTVT 204
DL+ V+++ D + + +HRHEP VT+ I+ + E++D++V+DKPS IPVHP GR+R NTV
Sbjct: 196 DLNIVLKDNDFLRNTVHRHEPPVTAEPIRLLAENEDVVVVDKPSSIPVHPCGRFRHNTVI 255
Query: 205 KILEKERGYT-VHPCNRLDRLTSGLMFLAKNPRGADRMADQMKAREVSKEYVARVVGEFP 263
IL KE +HP +RLDRLTSG++ AK ++R+ +Q++ R++ KEYV RV GEFP
Sbjct: 256 FILGKEHQLKELHPLHRLDRLTSGVLMFAKTAAVSERIHEQVRDRQLEKEYVCRVEGEFP 315
Query: 264 VGLIVVDKPLRTVDPKVGLNVTCKITDEGAKEARTSFERISFDGKTSIVRCKPFTGRTHQ 323
+ +P+ V KVG+ C++ G K T F+R+S++G++S+VRC+P TGRTHQ
Sbjct: 316 TEEVTCKEPILVVSYKVGV---CRVDPRG-KPCETVFQRLSYNGQSSVVRCRPLTGRTHQ 371
Query: 324 IRVHLQHLGHPIANDPIYSNPHIWGPSLGK 353
IRVHLQ LGHPI NDPIY N WGPS G+
Sbjct: 372 IRVHLQFLGHPILNDPIY-NSVAWGPSRGR 400
>7297709 [A] KOG1919 RNA pseudouridylate synthases
Length = 569
Score = 263 bits (671), Expect = 7e-70
Identities = 153/413 (37%), Positives = 224/413 (54%), Gaps = 57/413 (13%)
Query: 58 DKQGFQLKIQ-DVNGSRNKQ---TDPDYDVK---IEGALRKIVPYFFTYKTFCKERWRDR 110
D +G K++ + N + K+ +D YD E LRK+ PYFFT+ TF K RW D
Sbjct: 149 DDEGHVKKVKLEANSLKTKRPGFSDERYDETSYYFENGLRKVYPYFFTFTTFAKGRWVDE 208
Query: 111 KLIDIFIDEFRDRSPEYYRKTIAAGKVYLNDSVADLDSVVRNGDLITHEIHRHEPSVTSR 170
K++D+F+ EFR PE Y +++ AGK+ +N D +++ DL+ + +HRHE VTS+
Sbjct: 209 KILDVFVREFRAAPPEEYERSLEAGKLTVNSEKVPKDYKIKHNDLLANVVHRHEVPVTSQ 268
Query: 171 LIKTVFEDDDLLVIDKPSGIPVHPTGRYRFNTVTKILEKERGY-TVHPCNRLDRLTSGLM 229
IK V+ D D++V++KP+ IPVHP GRYR NTV IL KE + +RLDRLTSGL+
Sbjct: 269 PIKIVYMDKDIVVVNKPASIPVHPCGRYRHNTVVFILAKEHNLKNLRTIHRLDRLTSGLL 328
Query: 230 FLAKNPRGADRMADQMKAREVSKEYVARVVGEFPVGLIVVDKPLRTVDPKVGLNVTCKIT 289
+ A + Q++ R+V KEYV RV G FP G++ ++ + V K+G+ CK++
Sbjct: 329 LFGRTAEKARELELQIRTRQVQKEYVCRVEGRFPDGIVECNEKIDVVSYKIGV---CKVS 385
Query: 290 DEGAKEARTSFERISFDGKTSIVRCKPFTGRTHQIRVHLQHLGHPIANDPIYSNPHIWGP 349
+G K+ +T+F+RI G SIV CKP TGR HQIRVHLQ LG+PI+NDP+Y N ++GP
Sbjct: 386 PKG-KDCKTTFKRIGEVGSDSIVLCKPLTGRMHQIRVHLQFLGYPISNDPLY-NHEVFGP 443
Query: 350 SLGKD--------------------------------YEGDFSDIIGSLDLV-------- 369
G+ G+ D+ S +V
Sbjct: 444 LKGRGGDIGGITEEQLISNLISIHNAENWLGLEGDQIVSGEIKDVAASTSVVEAPSVVQA 503
Query: 370 ---GKTESAESWMHPDSFGEVLLGQQCEICDTELYSDPGPNDLDLWLHAYRYE 419
+TE + + + QC C Y DPG DL ++LHA++Y+
Sbjct: 504 PINSETEKPVISKNLEPSNDTTSDPQCSECKIN-YRDPGTKDLIMYLHAWKYK 555
>7297707 [A] KOG1919 RNA pseudouridylate synthases
Length = 506
Score = 251 bits (640), Expect = 3e-66
Identities = 137/330 (41%), Positives = 204/330 (61%), Gaps = 11/330 (3%)
Query: 63 QLKIQDVNGSRNKQTDPDYDVK---IEGALRKIVPYFFTYKTFCKERWRDRKLIDIFIDE 119
+L+ + + R TD Y +E LRK+ PY+FT+ TF K RW K++DIF E
Sbjct: 37 KLETKALKAKRPGFTDERYQETSYYMENGLRKVYPYYFTFTTFTKGRWVGEKILDIFSRE 96
Query: 120 FRDRSPEYYRKTIAAGKVYLNDSVADLDSVVRNGDLITHEIHRHEPSVTSRLIKTVFEDD 179
FR E Y + I G + +N +D +++ DL+ + +HRHE VT + IK V D+
Sbjct: 97 FRAHPAEEYERCIQTGTLTVNFEKVPIDYRLKHNDLLANIVHRHEVPVTCQPIKIVHMDE 156
Query: 180 DLLVIDKPSGIPVHPTGRYRFNTVTKILEKERGY-TVHPCNRLDRLTSGLMFLAKNPRGA 238
D++V++KP+ IPVHP GRYR NTV IL KE + +RLDRLTSGL+ ++P+ A
Sbjct: 157 DIVVVNKPASIPVHPCGRYRHNTVVFILAKEFNLKNLRTIHRLDRLTSGLLLFGRSPKKA 216
Query: 239 DRMADQMKAREVSKEYVARVVGEFPVGLIVVDKPLRTVDPKVGLNVTCKITDEGAKEART 298
+M Q++ R+V KEY+ RV G FP G++ +P+ V K+G+ CK++ +G K+ T
Sbjct: 217 RQMEQQIRNRQVEKEYICRVEGVFPDGIVECKEPIEVVSYKIGV---CKVSAKG-KDCTT 272
Query: 299 SFERISFDGKTSIVRCKPFTGRTHQIRVHLQHLGHPIANDPIYSNPHIWGPSLGKDYE-G 357
+F+++S +G TS+V CKP TGR HQIRVHLQ+LG+PI NDP+Y N ++GP G+ + G
Sbjct: 273 TFQKLSQNGTTSVVLCKPLTGRMHQIRVHLQYLGYPILNDPLY-NHEVFGPLKGRSGDIG 331
Query: 358 DFSDIIGSLDLVGKTESAESWMHPDSFGEV 387
SD DL+ +AE+W+ D ++
Sbjct: 332 GKSDEELIRDLI-NIHNAENWLGIDCDSDI 360
>CE11898 [A] KOG1919 RNA pseudouridylate synthases
Length = 432
Score = 218 bits (556), Expect = 2e-56
Identities = 141/428 (32%), Positives = 215/428 (49%), Gaps = 59/428 (13%)
Query: 58 DKQGFQLKIQDVNGSRNKQTDPDYDV------------KIEGALRKIVPYFFTYKTFCKE 105
DK+ + K ++ + R K DP+ V KI +R + PY+ Y+T K
Sbjct: 21 DKRKIEEKPENSSLKRKKFEDPNKKVDPLEELPMKVPFKIVDGVRHLAPYWACYRTRTKG 80
Query: 106 RWRDRKLIDIFIDEFRDRSPEYYRKTIAAGKVYLN-DSVADLDSVVRNGDLITHEIHRHE 164
RW RK++++F EF + Y + G++Y+N + + D+D V+RNGD + H HRHE
Sbjct: 81 RWIGRKMVEVFSGEFLSTNRNYAKIACKMGRIYVNGEQMTDVDYVMRNGDRVEHWAHRHE 140
Query: 165 PSVTSRLIKTVFEDDDLLVIDKPSGIPVHPTGRYRFNTVTKILEKERGYT-VHPCNRLDR 223
+ I+ + E DDL V++KP +PVH G+Y +TV L G T + +RLDR
Sbjct: 141 HPIRDLPIRVISETDDLFVVEKPPSLPVHTCGQYAIHTVLGQLRVNEGRTGLRVLHRLDR 200
Query: 224 LTSGLMFLAKNPRGADRMADQMKAREVSKEYVARVVGEFPVGLIVVDKPLRTVDPKVGLN 283
TSG++ AKN +K E SKEY+ +V G FP V ++P+ + + +
Sbjct: 201 ATSGVLLFAKNYETDLEFKTTLKQGEWSKEYICKVDGVFPDEEQVCEQPIGPL--VISMG 258
Query: 284 VTCKITDEGAKEARTSFERISFDGKTSIVRCKPFTGRTHQIRVHLQHLGHPIANDPIYSN 343
+ C D K+A++ F ++ DG S+V+ TGRTHQIRVH Q LGHPIA D IY N
Sbjct: 259 IQCVRPD--GKDAKSRFRKLWSDGTQSVVQVHIETGRTHQIRVHSQFLGHPIAGDQIY-N 315
Query: 344 PHIWGPSLGK--DYEGDFSDIIGSLDLVGKTESAESW---------------------MH 380
+WGP+ GK DY+ F ++ + V T E+W +
Sbjct: 316 SAVWGPTKGKNADYQKSFDEL---CEDVRNTHKCENWHEKPNPEFEQRMEHLAADTTPIT 372
Query: 381 PDSFGEVL-----LGQQCEICDTELYSDPGPNDLDLWLHAYRYESTELDSDGKKLWSYRT 435
P++ L + C+ C+ E P N L+LH +YE+ K WS++T
Sbjct: 373 PEAPSLTLEQRPEFDEICQKCNVESKKVP-ENHFQLYLHCLKYET--------KKWSFKT 423
Query: 436 DFPDWAIE 443
+ PDWA++
Sbjct: 424 EMPDWAVQ 431
>At5g51140 [A] KOG1919 RNA pseudouridylate synthases
Length = 395
Score = 216 bits (550), Expect = 8e-56
Identities = 122/369 (33%), Positives = 187/369 (50%), Gaps = 30/369 (8%)
Query: 82 DVKIEGALRKIVPYFFTYKTFCKERWRDRKLIDIFIDEFRDRSPEYYRKTIAAGKVYLND 141
D G R + PY+F + + +RW + ++D+F DEF+ R +YY + +G++ ++
Sbjct: 46 DYIFHGGRRHVRPYYFEFISHVNKRWTGKTIVDLFADEFKGRPRDYYVGAVKSGRIKVDG 105
Query: 142 SVADLDSVVRNGDLITHEIHRHEPSVTSRLIKTVFEDDDLLVIDKPSGIPVHPTGRYRFN 201
+ + +V++ ITH +HRHEP V + + ++ D++ + KP+ +PVHP G+YR N
Sbjct: 106 EIVPVSYIVKSSQKITHFLHRHEPPVMIDDVVILHQEPDVVTVCKPASVPVHPCGQYRKN 165
Query: 202 TVTKILEKERGY-TVHPCNRLDRLTSGLMFLAKNPRGADRMADQMKAREVSKEYVARVVG 260
T+ IL+ E T+ P +RLDRL SGL+ +A+ AD Q++ V K Y+A+V+G
Sbjct: 166 TIVGILDAEHDLGTLFPIHRLDRLVSGLLIIARTAAKADFFRQQIEGGMVKKRYIAKVIG 225
Query: 261 EFPVGLIVVDKPLRTVDPKVGLNVTCKITDEG------AKEARTSFERISFDGKTSIVRC 314
FP ++VD + + G + G K A T F RI +G S+V C
Sbjct: 226 VFPEDEMIVDANI-NYNGSEGRSTAEDANSSGDDKKVKGKPACTKFTRIDTNGTHSLVSC 284
Query: 315 KPFTGRTHQIRVHLQHLGHPIANDPIYSNPHI--WGPSLGKDYEGDFSDIIGSLDLVGKT 372
+P TGRTHQIRVHLQ+ GHPIANDP+Y N HI + K + I+ D V +
Sbjct: 285 EPVTGRTHQIRVHLQYTGHPIANDPLYLNQHIDNLETYIAKRIDAGERKIVSPDDYVYSS 344
Query: 373 ESAESWMHPDSFGEVLLGQQCEICDTELYSDPGPNDLDLWLHAYRYESTELDSDGKKLWS 432
E + + C C + +D LWLH +Y T W
Sbjct: 345 E------------DFSIDPMCTNCPKLIPQGYEEHDEALWLHCVQYCGTG--------WE 384
Query: 433 YRTDFPDWA 441
Y +P WA
Sbjct: 385 YECPYPSWA 393
>YOL066c_2 [F] KOG1018 Cytosine deaminase FCY1 and related enzymes
Length = 157
Score = 211 bits (538), Expect = 2e-54
Identities = 101/155 (65%), Positives = 122/155 (78%), Gaps = 2/155 (1%)
Query: 445 HRKFMELAIDEARNCGETQTAFNVGALLVNGTDILSTGYSRELPGNTHAEQCALDKYFTK 504
HR++ME+A+ EA CG T+TAF+VGA+LV+GT +L+TGYSRELPGNTHAEQCAL KY
Sbjct: 1 HRRYMEMAVKEAGKCGPTKTAFSVGAVLVHGTQVLATGYSRELPGNTHAEQCALIKYSQL 60
Query: 505 SEGAK--LPDGTIIYTTMEPCSLRLSGNLPCVDRIIQTTGAIKTVFVGVMEPDIFVKNNT 562
+P GT++YTTMEPCS RLSGN PC DRI+ T GAI TVFVGVMEPD FVKNNT
Sbjct: 61 HPNCPTIVPMGTVLYTTMEPCSFRLSGNEPCCDRILATQGAIGTVFVGVMEPDTFVKNNT 120
Query: 563 SYHKLAQYGIDYILIPGYEEECLKVACKGHDKTQN 597
S +KL +G++YI IPGYEEEC +A KGHD + +
Sbjct: 121 SLNKLESHGVNYIQIPGYEEECTIIAFKGHDNSDD 155
>YGR169c [A] KOG1919 RNA pseudouridylate synthases
Length = 404
Score = 206 bits (525), Expect = 6e-53
Identities = 140/408 (34%), Positives = 201/408 (48%), Gaps = 64/408 (15%)
Query: 82 DVKIEGALRKIVPYFFTYKTFCKERWRDRKLIDIFIDEFRDRSPEYYRKTIAAGKVYL-N 140
+V + LRK+ PY+ F K RW + LID+ + EF+ R YY I G L
Sbjct: 8 EVYTQNGLRKVRPYYNRRSAFVKGRWLGKLLIDVLVSEFKLRPRAYYLDQIRKGTYRLIR 67
Query: 141 DSVAD-----LDSVVRNGDLITHEIHRHEPSVTSRL---------------IKTVFEDDD 180
D V + ++++N D++ H+HEP V VFED+
Sbjct: 68 DGVPLVPDHLMTTIIKNHDVLETTTHKHEPPVKQWCSQEVEAEDLPGRIAGFNIVFEDES 127
Query: 181 LLVIDKPSGIPVHPTGRYRFNTVTKILEKERGYTVHPCNRLDRLTSGLMFLAKNPRGADR 240
+LVIDKPSGIPVHPTG++ NT+T++L K G PC RLD++TSGL+ LAKN + A
Sbjct: 128 ILVIDKPSGIPVHPTGQFYQNTITELL-KLHGVDALPCYRLDKITSGLLILAKNSQSAGE 186
Query: 241 MADQMKAREVSKEYVARVVGEFPVGLIVVDK-------------------PLRTVDPK-- 279
+ +++R++ K Y+ARV G FP +++D P+ ++DPK
Sbjct: 187 IQKSIRSRDMIKIYLARVKGRFPHSELILDNENAAETTFEDTSKVTVEMTPIYSIDPKRQ 246
Query: 280 --VGLNVTCKITDEGAKEARTSFERISF--DGKTSIVRCKPFTGRTHQIRVHLQHLGHPI 335
VGL+ +K+A T F I + ++V CKP TGRTHQIR+HL LGHPI
Sbjct: 247 FPVGLST--------SKDAITKFYPIRYFSHADETVVACKPITGRTHQIRIHLARLGHPI 298
Query: 336 ANDPIYSNPHIWGPSLGKDYEGDFSDIIGSLDLVGKTESAESWMHPDSFGEVLLGQQ--C 393
ND +Y + HI + F DL + D + C
Sbjct: 299 VNDSVYCS-HITKYPERLKFITQFPRWENQQDLDAEELKVRFQKFVDETKNNCRTMETFC 357
Query: 394 EICDTELYSDPGPNDLDLWLHAYRYESTELDSDGKKLWSYRTDFPDWA 441
C T DP +DL+LWLHA++YE + +GK + ++TD P WA
Sbjct: 358 PECHTVDLKDPVLSDLELWLHAWKYE----EINGK--FKFKTDLPKWA 399
>ECU05g0680 [A] KOG1919 RNA pseudouridylate synthases
Length = 318
Score = 162 bits (410), Expect = 1e-39
Identities = 94/249 (37%), Positives = 138/249 (54%), Gaps = 15/249 (6%)
Query: 95 YFFTYKTFCKERWRDRKLIDIFIDEFRDRSPEYYRKTIAAGKVYLNDSVADLDSVVRNGD 154
YFFTY+T KERW + +ID+ + EFR R+ +Y+ + G + +N ++ GD
Sbjct: 8 YFFTYRTNVKERWYRKPIIDVLVSEFRTRTRDYFLSALECGVITVNGEAVKPTRILGMGD 67
Query: 155 LITHEIHRHEPSVTSRLIKTVFEDDDLLVIDKPSGIPVHPTGRYRFNTVTKILEKERGYT 214
+I H +H H+P+ I + E+ D +V++KP GIP HPTG YR VTK L +
Sbjct: 68 VIRHTVHIHDPAHPE--IGVIKEEGDYIVVNKPPGIPCHPTGGYREYCVTKALFGDE--K 123
Query: 215 VHPCNRLDRLTSGLMFLAKNPRGADRMADQMKAREVSKEYVARVVGEFPVGLIVVDKPLR 274
V NRLD SG++ LA R + + + R+ K YVA+V G FP + VDK +
Sbjct: 124 VACINRLDMPVSGVLILA--VRNHSKCLEAI--RDAKKIYVAKVYGMFP-DKVDVDKRIG 178
Query: 275 TVDPKVGLNVTCKITDEGAKEARTSFERISFDGKTSIVRCKPFTGRTHQIRVHLQHLGHP 334
+ + + + G K T F R+ + S+V C+P TGRTHQIR+HLQ +G P
Sbjct: 179 CTEGRY------RHVNAGGKACLTLFRRLEYRDGYSLVECRPVTGRTHQIRIHLQSIGFP 232
Query: 335 IANDPIYSN 343
IAND +Y +
Sbjct: 233 IANDIMYGD 241
>SPCC4G3.16 [F] KOG1018 Cytosine deaminase FCY1 and related enzymes
Length = 405
Score = 124 bits (312), Expect = 3e-28
Identities = 67/148 (45%), Positives = 96/148 (64%), Gaps = 4/148 (2%)
Query: 445 HRKFMELAIDEARNCGETQTAFNVGALLVNGTDILSTGYSRELPGNTHAEQCALDKYFTK 504
H ++M A++EA+ C T +AF VGA++V I+STGYSRE PGNTHAE+CA++K+ K
Sbjct: 258 HEEYMLKALNEAKKCEPTDSAFCVGAVIVQNGKIVSTGYSRERPGNTHAEECAIEKFMLK 317
Query: 505 SEGAKLPDGTIIYTTMEPCSLRLSGNLPCVDRIIQTTGAIKTVFVGVMEPDIFVKNNTSY 564
+ L +G I+Y+TMEPCS RLS + C D I++ TV +G +EPDIFVK
Sbjct: 318 NPTDSL-EGAIMYSTMEPCSKRLSKKVSCTDLIVKQ--KFSTVVLGSLEPDIFVKCE-GV 373
Query: 565 HKLAQYGIDYILIPGYEEECLKVACKGH 592
L + GI I ++++CL+ A +GH
Sbjct: 374 DLLKKAGIVVIEKLTFQDDCLREAVRGH 401
>At3g52260 [A] KOG1919 RNA pseudouridylate synthases
Length = 346
Score = 79.7 bits (195), Expect = 1e-14
Identities = 72/264 (27%), Positives = 124/264 (46%), Gaps = 49/264 (18%)
Query: 132 IAAGKVYLNDSVA-DLDSVVRNGDLITHEIHRHEPSVTSRLIKTVFEDDDLLVIDKPSGI 190
I G++ ++ V D ++++R+G + + + T ++ ++EDDDL+ ++KPSG+
Sbjct: 56 IQNGQIQIDGEVVKDPNTLLRSGSKLVYSRLPWKEPDTPYSLEVLYEDDDLIALNKPSGL 115
Query: 191 PVHPTGRYRFNTVTKILE------------KERGYTVHPCNRLDRLTSGLMFLAKNPRGA 238
V P G ++ TV L+ +E + V P +RL R TSG++ AK
Sbjct: 116 QVLPGGLFQQRTVLTQLQWCFGKNDSYIGSRESPHPV-PVHRLGRGTSGILLCAKTKLAK 174
Query: 239 DRMA---------------DQM--KAREVSKEYVARVVGEFPVGLIVVDKPLRTVD-PKV 280
++A DQ R++SK Y A G +V+ +P+ V P V
Sbjct: 175 TKLAAYFAEGTSLVGSGNLDQECGTGRKLSKIYRALADGIVEEDEVVIKQPIGVVRYPGV 234
Query: 281 --GLNVTCKITDEGAKEARTSFERISF-----DGKTSIVRCKPFTGRTHQIRVHLQHLGH 333
GL V + E + +F ++ + S+V+ + +GR HQIR+HL ++GH
Sbjct: 235 AQGLYVA-------SPEGKPAFSKVFVLERDREKNCSLVKVEIQSGRPHQIRIHLAYMGH 287
Query: 334 PIANDPIY---SNPHIWGPSLGKD 354
P+ DP+Y P + P L D
Sbjct: 288 PLVGDPLYVAGGQPKCFDPDLVDD 311
>Hs20481524 [A] KOG1919 RNA pseudouridylate synthases
Length = 377
Score = 74.7 bits (182), Expect = 4e-13
Identities = 63/212 (29%), Positives = 106/212 (49%), Gaps = 25/212 (11%)
Query: 157 THEIHRHEPSVTSRLIKT--VFEDDDLLVIDKPSGIPVH--PTGRYRFNTVTKILEK--- 209
T ++ R P+V ++ + + +D +L+VI+KP G+PVH P + V IL K
Sbjct: 80 TRQLQRVHPNVLAKALTRGILHQDKNLVVINKPYGLPVHGGPGVQLCITDVLPILAKMLH 139
Query: 210 -ERGYTVHPCNRLDRLTSGLMFLAKNPRGADRMADQMKAREVSKEYVARVVGEFPVGLIV 268
+ +H C+RLD+ T+G+M LA + A ++ + + R+V K+Y A V V
Sbjct: 140 GHKAEPLHLCHRLDKETTGVMVLAWDKDMAHQVQELFRTRQVVKKYWAITVHVPMPSAGV 199
Query: 269 VDKPL-------RTVDPKVGLNVTCKITD---------EGAKEARTSFERISFDGKTSIV 312
VD P+ + K+ L+ + ++ D A+ A T ++ +S +++V
Sbjct: 200 VDIPIVEKEAQGQQQHHKMTLSPSYRMDDGKMVKVRRSRNAQVAVTQYQVLSSTLSSALV 259
Query: 313 RCKPFTGRTHQIRVHLQH-LGHPIANDPIYSN 343
+P TG HQ+RVHL L PI D YS+
Sbjct: 260 ELQPITGIKHQLRVHLSFGLDCPILGDHKYSD 291
>Hs14249470 [A] KOG1919 RNA pseudouridylate synthases
Length = 377
Score = 74.7 bits (182), Expect = 4e-13
Identities = 63/212 (29%), Positives = 106/212 (49%), Gaps = 25/212 (11%)
Query: 157 THEIHRHEPSVTSRLIKT--VFEDDDLLVIDKPSGIPVH--PTGRYRFNTVTKILEK--- 209
T ++ R P+V ++ + + +D +L+VI+KP G+PVH P + V IL K
Sbjct: 80 TRQLQRVHPNVLAKALTRGILHQDKNLVVINKPYGLPVHGGPGVQLCITDVLPILAKMLH 139
Query: 210 -ERGYTVHPCNRLDRLTSGLMFLAKNPRGADRMADQMKAREVSKEYVARVVGEFPVGLIV 268
+ +H C+RLD+ T+G+M LA + A ++ + + R+V K+Y A V V
Sbjct: 140 GHKAEPLHLCHRLDKETTGVMVLAWDKDMAHQVQELFRTRQVVKKYWAITVHVPMPSAGV 199
Query: 269 VDKPL-------RTVDPKVGLNVTCKITD---------EGAKEARTSFERISFDGKTSIV 312
VD P+ + K+ L+ + ++ D A+ A T ++ +S +++V
Sbjct: 200 VDIPIVEKEAQGQQQHHKMTLSPSYRMDDGKMVKVRRSRNAQVAVTQYQVLSSTLSSALV 259
Query: 313 RCKPFTGRTHQIRVHLQH-LGHPIANDPIYSN 343
+P TG HQ+RVHL L PI D YS+
Sbjct: 260 ELQPITGIKHQLRVHLSFGLDCPILGDHKYSD 291
>Hs17158025 [A] KOG1919 RNA pseudouridylate synthases
Length = 312
Score = 63.9 bits (154), Expect = 7e-10
Identities = 50/188 (26%), Positives = 78/188 (40%), Gaps = 21/188 (11%)
Query: 172 IKTVFEDDDLLVIDKPSGIPVHPTG-----------RYRFNTVTKILEKERGYTVHPCNR 220
+ V+ D LV++K + + RYRF ++ + + Y C++
Sbjct: 9 LSIVYRSRDFLVVNKHWDVRIDSKAWRETLTLQKQLRYRF---PELADPDTCYGFRFCHQ 65
Query: 221 LDRLTSGLMFLAKNPRGADRMADQMKAREVSKEYVARVVGEFPVGLIVVDKPLRTVDPKV 280
LD TSG + +A N A K R V+K Y+A + G + + + +
Sbjct: 66 LDFSTSGALCVALNKAAAGSAYRCFKERRVTKAYLALLRGHIQESRVTISHAIGRNSTEG 125
Query: 281 GLNVTCKITDEGAKEARTSF------ERISFDGK-TSIVRCKPFTGRTHQIRVHLQHLGH 333
+ C +G + + S E + G S V KP TGRTHQ+RVH LGH
Sbjct: 126 RAHTMCIEGSQGCENPKPSLTDLVVLEHGLYAGDPVSKVLLKPLTGRTHQLRVHCSALGH 185
Query: 334 PIANDPIY 341
P+ D Y
Sbjct: 186 PVVGDLTY 193
>At1g76050 [A] KOG1919 RNA pseudouridylate synthases
Length = 430
Score = 60.8 bits (146), Expect = 6e-09
Identities = 63/264 (23%), Positives = 109/264 (40%), Gaps = 58/264 (21%)
Query: 129 RKTIAAGKVYLNDSVAD-LDSVVRNGDLITHEIHRHEP---SVTSRLIKTVFEDDDLLVI 184
+ +I G V +N V D + V++GD + I +P + V+ED +LV+
Sbjct: 101 QSSIRLGLVTVNGRVVDKVSHNVKSGDEVNCTISELQPLKAEAEDIPLDIVYEDKHVLVV 160
Query: 185 DKPSGIPVHPT-GRYRFNTVTKILEK------------------------ERGYTVHPCN 219
+KP+ + VHP G V IL + T P +
Sbjct: 161 NKPAHMVVHPAPGNPTGTLVNGILHHCSLPCVDYSNSEEDDDSDEETFSDDEEMTTSPSS 220
Query: 220 -----------RLDRLTSGLMFLAKNPRGADRMADQMKAREVSKEYVARVVGEFPVGLIV 268
RLD+ T+GL+ +AK+ +A+Q K + + YV+ G V
Sbjct: 221 YAASVRPGIVHRLDKGTTGLLVVAKDEHSHAHLAEQFKLHTIERVYVSLTTG-------V 273
Query: 269 VDKPLRTVDPKVGLNVTCKITDEG---------AKEARTSFERISF--DGKTSIVRCKPF 317
P ++ +G + + +I A+ A + ++ I G +++V +
Sbjct: 274 PSPPQGRIEIPIGRDSSNRIRMAAIPGGVRGGRARHAASRYKVIETFAGGGSALVEWRLE 333
Query: 318 TGRTHQIRVHLQHLGHPIANDPIY 341
TGRTHQIR H +++G P+ D +Y
Sbjct: 334 TGRTHQIRAHAKYMGVPLLGDEVY 357
>At3g19440 [A] KOG1919 RNA pseudouridylate synthases
Length = 477
Score = 52.4 bits (124), Expect = 2e-06
Identities = 51/191 (26%), Positives = 84/191 (43%), Gaps = 25/191 (13%)
Query: 175 VFEDDDLLVIDKPSGIPVHPTGRYRFNT---VTKILEKERGYTVHPCNRLDRLTSGLMFL 231
+++D ++V++KP G+ V + + L+ ++ + +RLDR SGL+ L
Sbjct: 186 LYKDPAIIVLNKPHGLAVQGGSGIKTSIDELAASCLKFDKSESPRLVHRLDRDCSGLLVL 245
Query: 232 AKNPR--------------GADRMADQMKAREVSKEYVARVVGEFPVGLIVVDKPLRTVD 277
A+ GA + + + ++Y+A V+G P + PLR V
Sbjct: 246 ARTQTAATVLHSIFREKTTGASAYGVKKNVKSLKRKYMALVIGCPPRQRGQISAPLRKVV 305
Query: 278 PKVGLNVTCKITDEG----AKEARTSFERI--SFDGKTSIVRCKPFTGRTHQIRVH-LQH 330
G + + D G + A T + I S G T + +P TGR HQ+RVH +
Sbjct: 306 VDDGKSERITVNDNGELVSTQHAITEYRVIESSPHGYTWL-ELRPLTGRKHQLRVHCAEV 364
Query: 331 LGHPIANDPIY 341
LG PI D Y
Sbjct: 365 LGTPIVGDYKY 375
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.319 0.138 0.416
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 37,894,744
Number of Sequences: 60738
Number of extensions: 1741676
Number of successful extensions: 3313
Number of sequences better than 1.0e-05: 18
Number of HSP's better than 0.0 without gapping: 12
Number of HSP's successfully gapped in prelim test: 6
Number of HSP's that attempted gapping in prelim test: 3251
Number of HSP's gapped (non-prelim): 23
length of query: 597
length of database: 30,389,216
effective HSP length: 112
effective length of query: 485
effective length of database: 23,586,560
effective search space: 11439481600
effective search space used: 11439481600
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)