ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactVI6821 good TO KOG2606 Posttranslational modification, protein turnover, chaperones OTU (ovarian tumor)-like cysteine protease
r_klactVI6821 good TO KOG2606 Signal transduction mechanisms OTU (ovarian tumor)-like cysteine protease
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactVI6821 2376569 2375619 -317
(317 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YHL013c [TO] KOG2606 OTU (ovarian tumor)-like cysteine protease 326 3e-89
SPAC1952.03 [TO] KOG2606 OTU (ovarian tumor)-like cysteine protease 137 2e-32
Hs7706314 [TO] KOG2606 OTU (ovarian tumor)-like cysteine protease 124 1e-28
Hs16162192 [TO] KOG2606 OTU (ovarian tumor)-like cysteine protease 124 1e-28
At3g62940 [TO] KOG2606 OTU (ovarian tumor)-like cysteine protease 124 2e-28
CE03245 [TO] KOG2606 OTU (ovarian tumor)-like cysteine protease 122 7e-28
7294285 [TO] KOG2606 OTU (ovarian tumor)-like cysteine protease 114 1e-25
Hs17486108 [TO] KOG2606 OTU (ovarian tumor)-like cysteine protease 112 5e-25
At5g67170 [TO] KOG2605 OTU (ovarian tumor)-like cysteine protease 58 2e-08
>YHL013c [TO] KOG2606 OTU (ovarian tumor)-like cysteine protease
Length = 307
Score = 326 bits (835), Expect = 3e-89
Identities = 172/317 (54%), Positives = 218/317 (68%), Gaps = 32/317 (10%)
Query: 8 EELLARHRKERKDLTNQITSLKKQASKKTRKQVNAKCTDLEQELDTRHKSELAK---LNG 64
E++LARHRKE KDL N+IT +KKQA+K RK+VN+KC DL+ +L T+ ++E+ N
Sbjct: 14 EDILARHRKENKDLQNKITGMKKQATKSKRKEVNSKCLDLQDKLKTKQENEIRDWKIANN 73
Query: 65 VAFEHSDSEEITPXXXXXXXXXXXXPVQSVCKTDELQQREP-----ELQGKKRRNRQKER 119
F+ +E+TP S+ + ++ QQ P + Q KKRRNRQKER
Sbjct: 74 EVFDAEQEDEVTPEKLLEQL--------SISRDEKEQQNVPVQQQQQGQTKKRRNRQKER 125
Query: 120 LAKRDAEVARIKQQAMEEAAEQPNLKDIEQNSLDKVCVVLNLKQFDIQPDGHCLFNSILD 179
LAKRDA +A++K++A EA++QP+LK +EQ S+D++C + LKQFDIQPDGHCLF SILD
Sbjct: 126 LAKRDAAIAKMKEEAALEASKQPDLKKMEQESIDQLCELKKLKQFDIQPDGHCLFASILD 185
Query: 180 QLRLRHQTNNDIEYDYNFPEEYTGTKYVSEMDVYSLRSLSSSFIRENRDDFIPYLFDENT 239
QL+LRH K +MDV LR LS ++++E+RDDFIPYLFDE T
Sbjct: 186 QLKLRHDPK----------------KLDQDMDVMKLRWLSCNYVQEHRDDFIPYLFDEET 229
Query: 240 MTVKDLDEYTKTMETTAQWGGEVEILALSKVFNSTISILMSGRSTYRINEDAKNPELKIV 299
M +KD+DEYTK ME TAQWGGE+EILALS VF+ ISILMSGR NE KNPELK+V
Sbjct: 230 MKMKDIDEYTKEMEHTAQWGGEIEILALSHVFDCPISILMSGRPIQVYNECGKNPELKLV 289
Query: 300 YYKHSYTLGEHYNSLHD 316
YYKHSY LGEHYNSLHD
Sbjct: 290 YYKHSYALGEHYNSLHD 306
>SPAC1952.03 [TO] KOG2606 OTU (ovarian tumor)-like cysteine protease
Length = 324
Score = 137 bits (345), Expect = 2e-32
Identities = 94/324 (29%), Positives = 160/324 (49%), Gaps = 47/324 (14%)
Query: 8 EELLARHRKERKDLTNQITSLKKQ---ASKKTRKQVNAKCTDLEQELDTRHKSELAKLNG 64
EELL++ R+E K+L ++IT+L+KQ +KK ++ + K + +E +L +H +E KL+
Sbjct: 26 EELLSKQREECKELQSKITNLRKQLKEGNKKQKRALQQKISQMEADLSQKHATERQKLDK 85
Query: 65 VAFEHSDSEE-------ITPXXXXXXXXXXXXPVQSVCKTDELQQREPELQGKKRRNRQK 117
E +++++ + VQS T E ++P KK RNRQK
Sbjct: 86 GDEETNETQQEDLLNTLLQQMEDTKITTAEKSSVQSSLNTKENTPQQP----KKSRNRQK 141
Query: 118 ERLAKRDAEVARIKQQAMEEAAEQPNLKDIEQNSLDKVCVVLNLKQFDIQPDGHCLFNSI 177
ERL +R AE+ ++ +QA E+ + +LK+ E+ K+ L DI DG+CLF SI
Sbjct: 142 ERLERRKAEMKKMSEQAELESEKMADLKNEEKKKFSKILEEAGLVAVDIPADGNCLFASI 201
Query: 178 LDQLRLRHQTNNDIEYDYNFPEEYTGTKYVSEMDVYSLRSLSSSFIRENRDDFIPYLFDE 237
QL H +++ +LR+ S+ ++ ++ + F +L DE
Sbjct: 202 SHQLNYHHNV---------------------KLNSQALRNKSADYVLKHCEQFEGFLLDE 240
Query: 238 NTMTVKDLDEYTKTMETTAQWGGEVEILALSK-------VFNSTISILMSGRSTYRINED 290
+ V + +Y + ++WG ++EI AL+ V+N+ +L ST + +
Sbjct: 241 ESGEVLPVSDYCNEIRNNSKWGSDIEIQALANSLEVPVHVYNTEGPVLKFNPSTVKFEK- 299
Query: 291 AKNPELKIVYYKHSYTLGEHYNSL 314
L I YY+H + LG HYNSL
Sbjct: 300 ----PLCIAYYQHLFGLGAHYNSL 319
>Hs7706314 [TO] KOG2606 OTU (ovarian tumor)-like cysteine protease
Length = 289
Score = 124 bits (312), Expect = 1e-28
Identities = 88/318 (27%), Positives = 151/318 (46%), Gaps = 58/318 (18%)
Query: 7 QEELLARHRKERKDLTNQITSLKKQA---SKKTRKQVNAKCTDLEQELDTRHKSELAKLN 63
+E+LL RHRKE+K+L +I +K KK RKQ+ LE+E++ +H+ EL +L
Sbjct: 12 EEQLLRRHRKEKKELQAKIQGMKNAVPKNDKKRRKQLTEDVAKLEKEMEQKHREELEQLK 71
Query: 64 GVAFEHS-DSEEITPXXXXXXXXXXXXPVQSVCKTDELQQREPELQGKKRRNRQKERLAK 122
E+ DS + L+ + P + ++R +K L K
Sbjct: 72 LTTKENKIDSVAVNISNLV------------------LENQPPRISKAQKRREKKAALEK 113
Query: 123 RDAEVARIKQQAMEEAAEQPNLKDIEQNSLDKVCVVLNLKQFDIQP---DGHCLFNSILD 179
E RI + AE NL +K+ +L +Q +I+ DGHC++ +I D
Sbjct: 114 EREE--RIAE------AEIENLTGARHMESEKLAQILAARQLEIKQIPSDGHCMYKAIED 165
Query: 180 QLRLRHQTNNDIEYDYNFPEEYTGTKYVSEMDVYSLRSLSSSFIRENRDDFIPYLFDENT 239
QL+ + + V +LRS ++ +++ + +DF+P+L + NT
Sbjct: 166 QLKEKD----------------------CALTVVALRSQTAEYMQSHVEDFLPFLTNPNT 203
Query: 240 ---MTVKDLDEYTKTMETTAQWGGEVEILALSKVFNSTISILMSGRSTYRINEDAKNPEL 296
T ++ +Y + + TA WGG++E+ ALS + + I I+ + + E+ L
Sbjct: 204 GDMYTPEEFQKYCEDIVNTAAWGGQLELRALSHILQTPIEIIQADSPPIIVGEEYSKKPL 263
Query: 297 KIVYYKHSYTLGEHYNSL 314
+VY +H+Y LGEHYNS+
Sbjct: 264 ILVYMRHAYGLGEHYNSV 281
>Hs16162192 [TO] KOG2606 OTU (ovarian tumor)-like cysteine protease
Length = 293
Score = 124 bits (312), Expect = 1e-28
Identities = 88/318 (27%), Positives = 151/318 (46%), Gaps = 58/318 (18%)
Query: 7 QEELLARHRKERKDLTNQITSLKKQA---SKKTRKQVNAKCTDLEQELDTRHKSELAKLN 63
+E+LL RHRKE+K+L +I +K KK RKQ+ LE+E++ +H+ EL +L
Sbjct: 12 EEQLLRRHRKEKKELQAKIQGMKNAVPKNDKKRRKQLTEDVAKLEKEMEQKHREELEQLK 71
Query: 64 GVAFEHS-DSEEITPXXXXXXXXXXXXPVQSVCKTDELQQREPELQGKKRRNRQKERLAK 122
E+ DS + L+ + P + ++R +K L K
Sbjct: 72 LTTKENKIDSVAVNISNLV------------------LENQPPRISKAQKRREKKAALEK 113
Query: 123 RDAEVARIKQQAMEEAAEQPNLKDIEQNSLDKVCVVLNLKQFDIQP---DGHCLFNSILD 179
E RI + AE NL +K+ +L +Q +I+ DGHC++ +I D
Sbjct: 114 EREE--RIAE------AEIENLTGARHMESEKLAQILAARQLEIKQIPSDGHCMYKAIED 165
Query: 180 QLRLRHQTNNDIEYDYNFPEEYTGTKYVSEMDVYSLRSLSSSFIRENRDDFIPYLFDENT 239
QL+ + + V +LRS ++ +++ + +DF+P+L + NT
Sbjct: 166 QLKEKD----------------------CALTVVALRSQTAEYMQSHVEDFLPFLTNPNT 203
Query: 240 ---MTVKDLDEYTKTMETTAQWGGEVEILALSKVFNSTISILMSGRSTYRINEDAKNPEL 296
T ++ +Y + + TA WGG++E+ ALS + + I I+ + + E+ L
Sbjct: 204 GDMYTPEEFQKYCEDIVNTAAWGGQLELRALSHILQTPIEIIQADSPPIIVGEEYSKKPL 263
Query: 297 KIVYYKHSYTLGEHYNSL 314
+VY +H+Y LGEHYNS+
Sbjct: 264 ILVYMRHAYGLGEHYNSV 281
>At3g62940 [TO] KOG2606 OTU (ovarian tumor)-like cysteine protease
Length = 332
Score = 124 bits (311), Expect = 2e-28
Identities = 90/324 (27%), Positives = 159/324 (48%), Gaps = 45/324 (13%)
Query: 8 EELLARHRKERKDLTNQITSLKKQASKKTRKQVNAKCTDLEQE---LDTRHKS-ELAKLN 63
EE+LARHR+E K L N+ T +KK A+K ++ + AK +E + L T+ K +L +L
Sbjct: 29 EEMLARHRQEIKQLQNKETEMKKAAAKGSKAEQKAKKKQVEDDISKLSTKLKDKQLKELA 88
Query: 64 GVAFEHSDSEEITPXXXXXXXXXXXXPVQSVCKTDELQQREPELQGKKRRNRQKERLAKR 123
F S S I V+++ Q+E K + R+K +
Sbjct: 89 SQGFSSSSSNNIAKDETTEKKGDIDTLVRAIAGVSVTAQQEHSKPSKSVKRREKRAKEEA 148
Query: 124 DAEVARIKQQAMEEAAEQPNLKDIEQNSLDKVCVVLNLKQFDIQPDGHCLFNSILDQLRL 183
D E Q+ EE + + + +E L+K L L +I+PDGHCL+ ++ +QL
Sbjct: 149 DRE-----QRIKEEQSHVKSDRMVENAKLEKKLKPLGLTVSEIKPDGHCLYRAVENQLAN 203
Query: 184 RHQTNNDIEYDYNFPEEYTGTKYVSEMDVYSLRSLSSSFIRENRDDFIPYLF-----DEN 238
R + Y +LR +++S++RE++ DF+P+ D N
Sbjct: 204 RSGGASPYTYQ-------------------NLREMAASYMREHKTDFLPFFLSETEGDSN 244
Query: 239 TMTVKD-LDEYTKTMETTAQWGGEVEILALS-------KVFNSTISILMSGRSTYRINED 290
+ + ++ ++Y + +E+TA WG ++E+ AL+ KV++ + + G+ YR +D
Sbjct: 245 SGSAEERFEKYCREVESTAAWGSQLELGALTHCLRKHIKVYSGSFPDVEMGKE-YRSGDD 303
Query: 291 AKNPELKIVYYKHSYTLGEHYNSL 314
+ L + Y++H++ LGEHYNS+
Sbjct: 304 S---SLMLSYHRHAFGLGEHYNSV 324
>CE03245 [TO] KOG2606 OTU (ovarian tumor)-like cysteine protease
Length = 309
Score = 122 bits (306), Expect = 7e-28
Identities = 96/339 (28%), Positives = 166/339 (48%), Gaps = 60/339 (17%)
Query: 1 MSTETAQEE---LLARHRKERKDLTNQITSLKKQA---SKKTRKQVNAKCTDLEQELDTR 54
MS++ Q+E +LARHR+E+K+L +I + KK A +K+ +K+ A+C +E+E+D R
Sbjct: 1 MSSDGEQDEENPILARHRREKKELRGKILAKKKAAKCGNKQMQKEAGAECEKMEKEMDER 60
Query: 55 HKSELAKL------NGVAFEHSDSEEITPXX--XXXXXXXXXXPVQSV-CKTDELQQREP 105
HK EL + V E+ ++ ++P P S KT ++ +
Sbjct: 61 HKKELEEAKKPEESEAVPAENPEASTLSPPSPNPEGSDNDGEGPSSSAFYKTVKISNKAA 120
Query: 106 ELQGKKRRNRQKERLAK---RDAEVARIKQQAMEEAAEQPNLKDIEQNSLDKVCVVLNLK 162
+ Q KK++ K + A+ ++A ++ + ME+AA + L + ++K
Sbjct: 121 KKQDKKKKTADKMKAAEAADKEAGKNQLSDRQMEKAAVKEMLAED------------HMK 168
Query: 163 QFDIQPDGHCLFNSILDQLRLRHQTNNDIEYDYNFPEEYTGTKYVSEMDVYSLRSLSSSF 222
DI DG C++N+I QL+ EE E+ V LR ++
Sbjct: 169 MIDIPADGDCMYNAISHQLQ----------------EEGI------EISVRKLRKRCGTY 206
Query: 223 IRENRDDFIPYLFD-ENTMTVKDLDEYTKTMETTAQ----WGGEVEILALSKVFNSTISI 277
+RE+ +DF P++ D N + Y +E A+ WGGE+E+ A S +F TI +
Sbjct: 207 MREHSEDFRPFIEDMANMDSDSSWATYLGGVENVAEIGGVWGGELELKACSMIFEKTIVV 266
Query: 278 LMSGRSTYRINEDAKNPE---LKIVYYKHSYTLGEHYNS 313
+ I E+ +P+ L++V+ +H+Y+LGEHYNS
Sbjct: 267 YKQYGGRHTIGEEYSSPKDRALRVVFLRHAYSLGEHYNS 305
>7294285 [TO] KOG2606 OTU (ovarian tumor)-like cysteine protease
Length = 312
Score = 114 bits (286), Expect = 1e-25
Identities = 85/324 (26%), Positives = 148/324 (45%), Gaps = 47/324 (14%)
Query: 4 ETAQEELLARHRKERKDLTNQITSLKKQA---SKKTRKQVNAKCTDLEQELDTRHKSELA 60
E + E++ ARHR+ERKDL ++ ++KK A +K RK+ + LE EL+ RHK+EL
Sbjct: 17 EVSLEDIGARHRRERKDLQAKLQAMKKNAPKNNKNKRKEFLEEMARLEGELEQRHKAEL- 75
Query: 61 KLNGVAFEHSDSEEITPXXXXXXXXXXXXPVQSVCKTDELQQREPEL-------QGKKRR 113
+ +++ E P V D ++++E +L + +KRR
Sbjct: 76 -------KAAEAMEAPVLVEPVVKEPAEKPETEVTDDDGIEEKEEQLAPNQRVSKAQKRR 128
Query: 114 NRQKERLAKRDAEVARIKQQAMEEAAEQPNLKDIEQNSLDKVCVVLNLKQFDIQPDGHCL 173
+++ + R+AE+ + ++ AA QP K IE + L +I DG CL
Sbjct: 129 DKKAKEARAREAEI----KTELQNAANQPTPKLIELQQITAKLSQRQLSLHNIPSDGDCL 184
Query: 174 FNSILDQLRLRHQTNNDIEYDYNFPEEYTGTKYVSEMDVYSLRSLSSSFIRENRDDFIPY 233
+ SI QL + + ++ LR +++++R ++D I Y
Sbjct: 185 YQSIRHQLIVNALPGHSVQ---------------------ELREETANYVRAHKDSLISY 223
Query: 234 LFDENT---MTVKDLDEYTKTMETTAQWGGEVEILALSKVFNSTISILMS-GRSTYRINE 289
+ T + + ++Y + T WGG +E+ A+S + I ++ + G T E
Sbjct: 224 MIHPETGDILNDQQFEQYCHDIAKTHAWGGHIELKAISSLLRVPIEVIQAEGAPTLLGQE 283
Query: 290 DAKNPELKIVYYKHSYTLGEHYNS 313
+ L I Y++H Y LG HYNS
Sbjct: 284 EFGGSPLIICYHRHIYQLGAHYNS 307
>Hs17486108 [TO] KOG2606 OTU (ovarian tumor)-like cysteine protease
Length = 288
Score = 112 bits (281), Expect = 5e-25
Identities = 82/323 (25%), Positives = 153/323 (46%), Gaps = 61/323 (18%)
Query: 4 ETAQEELLARHRKERKDLTNQITSLKK---QASKKTRKQVNAKCTDLEQELDTRHKSELA 60
++ Q+ +L RH++ER++L QI SLK + K RKQ+ +E E+ +H+ EL
Sbjct: 5 KSEQQRILRRHQRERQELQAQIRSLKNSVPKTDKTKRKQLLQDVARMEAEMAQKHRQELE 64
Query: 61 KLNGVAFEHSDSEEITPXXXXXXXXXXXXPVQSVCKTDELQQREPELQGKKRRNRQKERL 120
K + S E + V+ + K + L+ R P + +R++ER+
Sbjct: 65 KFQ----DDSSIESV---------------VEDLAKMN-LENRPPR---SSKAHRKRERM 101
Query: 121 AKRDAEVARIKQQAMEEAAEQPNLKDIEQNSLDKVCVVLNLKQFD---IQPDGHCLFNSI 177
+ E +Q+++ +A +L ++ +K+ +L + + I DGHC++ +I
Sbjct: 102 ESEERE----RQESIFQAEMSEHLAGFKREEEEKLAAILGARGLEMKAIPADGHCMYRAI 157
Query: 178 LDQLRLRHQTNNDIEYDYNFPEEYTGTKYVSEMDVYSLRSLSSSFIRENRDDFIPYLFDE 237
DQL V + V LR ++S+++++ D+F+P+ +
Sbjct: 158 QDQL-------------------------VFSVSVEMLRCRTASYMKKHVDEFLPFFSNP 192
Query: 238 NTMTVKDLDE---YTKTMETTAQWGGEVEILALSKVFNSTISILMSGRSTYRINEDAKNP 294
T D+ Y + T WGG++E+ ALS V + I ++ + T I E+
Sbjct: 193 ETSDSFGYDDFMIYCDNIVRTTAWGGQLELRALSHVLKTPIEVIQADSPTLIIGEEYVKK 252
Query: 295 ELKIVYYKHSYTLGEHYNSLHDL 317
+ +VY +++Y+LGEHYNS+ L
Sbjct: 253 PIILVYLRYAYSLGEHYNSVTPL 275
>At5g67170 [TO] KOG2605 OTU (ovarian tumor)-like cysteine protease
Length = 382
Score = 58.2 bits (139), Expect = 2e-08
Identities = 49/172 (28%), Positives = 73/172 (41%), Gaps = 36/172 (20%)
Query: 145 KDIEQNSLDKVCVVLNLKQFDIQPDGHCLFNSILDQLRLRHQTNNDIEYDYNFPEEYTGT 204
KD + + L LK + DG+C F +I DQL +N
Sbjct: 28 KDCDLSQFRAQLDALGLKIIQVTADGNCFFRAIADQLEGNEDEHN--------------- 72
Query: 205 KYVSEMDVYSLRSLSSSFIRENRDDFIPYLFDENTMTVKDLDEYTKTMETTAQWGGEVEI 264
KY R++ +I +NR+ F P++ D+ ++Y KTM+ W G +E+
Sbjct: 73 KY---------RNMIVLYIVKNREMFEPFIEDD-----VPFEDYCKTMDDDGTWAGNMEL 118
Query: 265 LALSKVFNSTISI--LMSGRSTYRINEDAKNPELKIVYYKHSYTLGEHYNSL 314
A S V S I I MS R R ED + + + Y+ GEHYNS+
Sbjct: 119 QAASLVTRSNICIHRNMSPRWYIRNFEDTRTRMIHLSYHD-----GEHYNSV 165
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.312 0.129 0.353
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,653,310
Number of Sequences: 60738
Number of extensions: 723705
Number of successful extensions: 3593
Number of sequences better than 1.0e-05: 9
Number of HSP's better than 0.0 without gapping: 5
Number of HSP's successfully gapped in prelim test: 4
Number of HSP's that attempted gapping in prelim test: 3554
Number of HSP's gapped (non-prelim): 9
length of query: 317
length of database: 30,389,216
effective HSP length: 106
effective length of query: 211
effective length of database: 23,950,988
effective search space: 5053658468
effective search space used: 5053658468
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)