ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactVI6861 good R KOG0804 General function prediction only Cytoplasmic Zn-finger protein BRAP2 (BRCA1 associated protein)
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactVI6861 2390779 2389229 -517
(517 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YHL010c [R] KOG0804 Cytoplasmic Zn-finger protein BRAP2 (BRCA1 a... 437 e-122
SPAC16E8.13 [R] KOG0804 Cytoplasmic Zn-finger protein BRAP2 (BRC... 332 6e-91
Hs10800417 [R] KOG0804 Cytoplasmic Zn-finger protein BRAP2 (BRCA... 261 1e-69
7300491 [R] KOG0804 Cytoplasmic Zn-finger protein BRAP2 (BRCA1 a... 242 1e-63
At2g26000 [R] KOG0804 Cytoplasmic Zn-finger protein BRAP2 (BRCA1... 239 7e-63
CE28903 [R] KOG0804 Cytoplasmic Zn-finger protein BRAP2 (BRCA1 a... 237 3e-62
At2g42160 [R] KOG0804 Cytoplasmic Zn-finger protein BRAP2 (BRCA1... 219 1e-56
Hs14149817 [O] KOG1867 Ubiquitin-specific protease 65 3e-10
Hs21361749 [O] KOG1867 Ubiquitin-specific protease 63 9e-10
CE25887 [B] KOG1343 Histone deacetylase complex catalytic compon... 59 2e-08
Hs5454156 [O] KOG1873 Ubiquitin-specific protease 58 3e-08
At4g11680 [O] KOG0800 FOG: Predicted E3 ubiquitin ligase 55 3e-07
At1g72220 [O] KOG0800 FOG: Predicted E3 ubiquitin ligase 55 3e-07
At3g58720 [O] KOG0800 FOG: Predicted E3 ubiquitin ligase 53 1e-06
At1g63170 [O] KOG0800 FOG: Predicted E3 ubiquitin ligase 53 1e-06
Hs14249724 [O] KOG1873 Ubiquitin-specific protease 52 3e-06
At3g16720 [O] KOG0800 FOG: Predicted E3 ubiquitin ligase 51 4e-06
HsM18874088 [O] KOG1870 Ubiquitin C-terminal hydrolase 51 5e-06
Hs21489975 [O] KOG1870 Ubiquitin C-terminal hydrolase 51 5e-06
YBR058c [O] KOG0944 Ubiquitin-specific protease UBP14 50 6e-06
CE26241 [O] KOG1867 Ubiquitin-specific protease 50 6e-06
At1g12760 [O] KOG0800 FOG: Predicted E3 ubiquitin ligase 50 6e-06
At1g26800 [O] KOG0800 FOG: Predicted E3 ubiquitin ligase 50 8e-06
7299505 [O] KOG0800 FOG: Predicted E3 ubiquitin ligase 50 8e-06
>YHL010c [R] KOG0804 Cytoplasmic Zn-finger protein BRAP2 (BRCA1 associated
protein)
Length = 585
Score = 437 bits (1124), Expect = e-122
Identities = 223/501 (44%), Positives = 327/501 (64%), Gaps = 58/501 (11%)
Query: 56 IESEWCGHGIIRLFKNGHASVGTFDDKELYRELGDGRMLAILFIPNYLTINRLLGWFIGE 115
I S++ GHGIIRLFK +A+ T ++KE+ GD M+ ILF+P Y T++ LL ++IG+
Sbjct: 78 ITSQYLGHGIIRLFKLSNAN-NTLNEKEILTIPGDDTMICILFVPTYFTVHDLLHFYIGD 136
Query: 116 ETTN-QVTHLQLIKMNKEKG---RFMLLMKFKEQSLAKEFQKLFDGKKFNEIDPETCHVV 171
+ N QV++ ++++ N++KG F +L+KF+ AK F++ F+GK F+ +DPETCHV+
Sbjct: 137 DIVNKQVSNFRILR-NQQKGMGFNFTVLIKFRNALDAKNFKEEFNGKSFSRMDPETCHVI 195
Query: 172 AIKELIFHQGMFSED--KDALPYMLKYPFTQSSSEQSDGLIELPMCPVCLEKLDSEVTGL 229
++KE++F + +F + PY+L PFT ++ +ELP CPVCLE++DSE TGL
Sbjct: 196 SVKEIVFQKKLFQRPAANEDFPYLLTDPFTVKKKKELVK-VELPTCPVCLERMDSETTGL 254
Query: 230 VTTPCQHTFHCKCLDQWKNGNCPVCRYSQLKDVNNEPLPR-------CLECGETNNLWIC 282
VT PCQHTFHC+CL++WKN CPVCR+S L+ ++ E L + C CG T+NLWIC
Sbjct: 255 VTIPCQHTFHCQCLNKWKNSRCPVCRHSSLR-LSRESLLKQAGDSAHCATCGSTDNLWIC 313
Query: 283 LICGHLGCGRYNSQHAICHYEQSNHCFAMDLTTKRVWDYAGDNYVHRIVQNEIDGKLVEV 342
LICG++GCGRYNS+HAI HYE++ HCFAMD+ T+RVWDYAGDNYVHR+VQNE+DGKLVEV
Sbjct: 314 LICGNVGCGRYNSKHAIKHYEETLHCFAMDIRTQRVWDYAGDNYVHRLVQNEVDGKLVEV 373
Query: 343 GESHDGSNTK------------------------------------RNKEYHLEYVQVLL 366
G S D N R++EYHLEYVQVL+
Sbjct: 374 GGSGDDDNNDIGNSDELQNVVYGNRSKNGEKSNSNKKDGELAANFLRHREYHLEYVQVLI 433
Query: 367 SQLESQREYYEGQIYNMHERVKSLESDMQVSRQKDDHKQLKKLVEESMQE----MKNRLK 422
SQLESQREYYE ++ + + + + +D K ++ ++ Q+ K++L+
Sbjct: 434 SQLESQREYYELKLQEKDQTASDSSNVESLKKSMEDLKLQFQVTQKEWQKREMAQKSKLE 493
Query: 423 EEMLLNSGLQQNLDHLTKQMEKFSLEKQKLQDENQELQSQIQDLMFHFESQEKFAE-DSE 481
E+ML+ GLQ NLDHL+K+ E+ E + L++ Q+L+ Q++DLMF+ +SQEKF + D
Sbjct: 494 EDMLVIEGLQANLDHLSKKQEQLERENKALEESKQDLEEQVKDLMFYLDSQEKFKDADES 553
Query: 482 LQNATLVLQPPPGSEASSSAK 502
++ T+++Q P G+ +S +K
Sbjct: 554 VKEGTILIQQPHGAAQASKSK 574
>SPAC16E8.13 [R] KOG0804 Cytoplasmic Zn-finger protein BRAP2 (BRCA1 associated
protein)
Length = 547
Score = 332 bits (852), Expect = 6e-91
Identities = 192/496 (38%), Positives = 284/496 (56%), Gaps = 46/496 (9%)
Query: 42 IPMLSLHSCSNKV-SIESEWCGHGIIRLFKNGHASVGTFDDKELYRELGDGRMLAILFIP 100
I +LS+ S+KV +E GHG++ L++ + FD G +LAIL IP
Sbjct: 44 IKLLSMDFPSSKVPEVEETSLGHGVVHLYRVFPSESHEFD--------APGLILAILAIP 95
Query: 101 NYLTINRLLGWFIGEETTNQVTHLQLIKMNKEKGRFMLLMKFKEQSLAKEFQKLFDGKKF 160
Y++ + +LG F+GE+ + H++L+K K+ R M L+KFK+Q+ F F+GK F
Sbjct: 96 LYMSPSDVLG-FLGEKHCKSIQHIRLLK-TKDPNRIMALLKFKDQASVIRFYTEFNGKAF 153
Query: 161 NEIDPETCHVVAIKELIFHQGMFSEDKDALPYMLKYPFTQSSSEQSDGLIELPMCPVCLE 220
++IDPETCHV+ I ++ M S D + L P ++ + + LIELP C VCLE
Sbjct: 154 SQIDPETCHVLHIDKVNIKYPMESSDSSSTEQQLVGPSSKPFASTTPALIELPTCVVCLE 213
Query: 221 KLDSEVTGLVTTPCQHTFHCKCLDQWKNGNCPVCRYSQLKDVNNEPLPRCLECGETNNLW 280
++DS +TGL+T CQHTFHC CL +W N +CPVCRY+Q K ++E +C C +LW
Sbjct: 214 RMDSSITGLITIVCQHTFHCPCLQKWGNSSCPVCRYTQ-KVQSSEFQSKCTVCCYDKDLW 272
Query: 281 ICLICGHLGCGRYNSQHAICHYEQSNHCFAMDLTTKRVWDYAGDNYVHRIVQNEIDGKLV 340
ICLICG++GCGRY+ HA HY + HC+AM+L T+RVWDYAGDNYVHR++Q+E DGKLV
Sbjct: 273 ICLICGNIGCGRYHDAHAKQHYVDTAHCYAMELETQRVWDYAGDNYVHRLLQSETDGKLV 332
Query: 341 EV---GES-----HDGSNTKRNKEYHLEYVQVLLSQLESQREYYEGQIYNMHERVKSLES 392
E+ G+S + +K + LEY Q+L+SQLESQR YYE + NM +++ +
Sbjct: 333 ELSTDGKSSGWTGSSATESKLRDKMGLEYTQILVSQLESQRLYYESHLSNMSQKLSRVNE 392
Query: 393 DMQV----------------SRQKDDHKQLK------KLVEESMQEMKNRLKEEMLLNSG 430
++ + SR +LK K V ++ +K+ +EE +N
Sbjct: 393 ELVLKTKIATASSNANTDLRSRVDISESKLKKRDDKLKRVSSQLEHLKHNYEEEKSMNEN 452
Query: 431 LQQNLDHLTKQMEKFSLEKQKLQDENQELQSQIQDLMFHFESQ---EKFAEDSELQNATL 487
L + L KQ S + +Q + +L Q++DLMF + +K + ELQN T+
Sbjct: 453 LLVRIQTLEKQNTTKSDQIVSMQFQINDLNEQLRDLMFTISASQEIQKMGQSEELQNGTI 512
Query: 488 VLQPPPGSEASSSAKN 503
VL P + S+S K+
Sbjct: 513 VL-PNNSTVRSNSVKS 527
>Hs10800417 [R] KOG0804 Cytoplasmic Zn-finger protein BRAP2 (BRCA1 associated
protein)
Length = 592
Score = 261 bits (668), Expect = 1e-69
Identities = 157/436 (36%), Positives = 235/436 (53%), Gaps = 52/436 (11%)
Query: 63 HGIIRLFKNGHASVGTFDDKELYRELGDGRMLAILFIPNYLTINRLLGWFIGEETTNQVT 122
HGI+ L+K + L ++ ML IL +P +T + L+ + N V
Sbjct: 139 HGIMHLYKTNKMT-------SLKEDVRRSAMLCILTVPAAMTSHDLMKFVA---PFNDVI 188
Query: 123 HLQLIKMNKEKGRFMLLMKFKEQSLAKEFQKLFDGKKFNEIDPETCHVVAIKELIFHQGM 182
I + ++M+L+KF+ Q+ A F +G++FN I+ + C +V ++ + +
Sbjct: 189 EQMKIIRDSTPNQYMVLIKFRAQADADSFYMTCNGRQFNSIEDDVCQLVYVERA---EVL 245
Query: 183 FSEDKDALPYMLKYPFTQSSSEQSDGLIELPMCPVCLEKLDSEVTGLVTTPCQHTFHCKC 242
SED +LP M L ELP C VCLE++D V G++TT C H+FH +C
Sbjct: 246 KSEDGASLPVM--------------DLTELPKCTVCLERMDESVNGILTTLCNHSFHSQC 291
Query: 243 LDQWKNGNCPVCRYSQLKDVNNEPLPRCLECGETNNLWICLICGHLGCGRYNSQHAICHY 302
L +W + CPVCRY Q + E +C ECG NLWICLICGH+GCGRY S+HA H+
Sbjct: 292 LQRWDDTTCPVCRYCQTPEPVEEN--KCFECGVQENLWICLICGHIGCGRYVSRHAYKHF 349
Query: 303 EQSNHCFAMDLTTKRVWDYAGDNYVHRIVQNEIDGKLVEVGESHDGSNTKRNKEYHLEYV 362
E++ H +AM LT RVWDYAGDNYVHR+V ++ DGK+V+ D ++ LEY
Sbjct: 350 EETQHTYAMQLTNHRVWDYAGDNYVHRLVASKTDGKIVQYECEGDTCQEEKIDALQLEYS 409
Query: 363 QVLLSQLESQREYYEGQIYNMH----ERVKSLESDMQVSRQKDD---HKQLKKLVEESMQ 415
+L SQLESQR Y+E +I + E + ++++ + + +K D HK L E+
Sbjct: 410 YLLTSQLESQRIYWENKIVRIEKDTAEEINNMKTKFKETIEKCDNLEHKLNDLLKEKQSV 469
Query: 416 EMK------------NRLKEEMLLNSGLQQN---LDHLTKQMEKFSLEKQKLQD-ENQEL 459
E K N LKEE +N L+ N L + K+ E+ E +D + E+
Sbjct: 470 ERKCTQLNTKVAKLTNELKEEQEMNKCLRANQVLLQNKLKEEERVLKETCDQKDLQITEI 529
Query: 460 QSQIQDLMFHFESQEK 475
Q Q++D+MF+ E+Q+K
Sbjct: 530 QEQLRDVMFYLETQQK 545
>7300491 [R] KOG0804 Cytoplasmic Zn-finger protein BRAP2 (BRCA1 associated
protein)
Length = 482
Score = 242 bits (617), Expect = 1e-63
Identities = 145/466 (31%), Positives = 244/466 (52%), Gaps = 67/466 (14%)
Query: 64 GIIRLFKNGHASVGTFDDKELYRELGDGRMLAILFIPNYLTINRLLGWFIGEETTNQVTH 123
G+I L+K ++++ +E L +L +P L + LL + ++ H
Sbjct: 56 GLIHLYKK--------NERKAIKE-APSNQLCLLAVPATLNCHDLLNFIAPCHA--EIKH 104
Query: 124 LQLIKMNKEKGRFMLLMKFKEQSLAKEFQKLFDGKKFNEIDPET-CHVVAIKELIFHQGM 182
+Q+++ + +FM+L++F+ A EF K ++G +N ++P++ CH V + E+
Sbjct: 105 IQIVR-DGSPNQFMVLLEFRSNESALEFYKSYNGSTYNSLEPDSLCHAVWVSEV------ 157
Query: 183 FSEDKDALPYMLKYPFTQSSSEQSDGLIELPMCPVCLEKLDSEVTGLVTTPCQHTFHCKC 242
+ P M G ELP CPVCLE++D V G++T C H FH C
Sbjct: 158 -ERSEHGAPPM--------------GHTELPTCPVCLERMDESVDGVLTILCNHAFHASC 202
Query: 243 LDQWKNGNCPVCRYSQLKDVNNEPLPRCLECGETNNLWICLICGHLGCGRYNSQHAICHY 302
L +W + CPVCR+ Q + + + C+EC T++LWICLICGH+GCGRY HA H+
Sbjct: 203 LMKWGDSTCPVCRHVQTPGLVEDSV--CMECEGTDSLWICLICGHVGCGRYQGGHAAAHF 260
Query: 303 EQSNHCFAMDLTTKRVWDYAGDNYVHRIVQNEIDGKLVEVGESHDGSNTKRNKEYHLEYV 362
+NH FAM L T VWDYAGDN+VHR+ QN+ DGKLV ++ ++ +E+
Sbjct: 261 RATNHTFAMQLGTSSVWDYAGDNFVHRLFQNKSDGKLV-ASQTEKDEREEKIDSMQMEFT 319
Query: 363 QVLLSQLESQREYYEGQIYNMHERVKSLES-------------DMQVSRQKDDHKQLKKL 409
+L SQL++QR+YYE ++ + + ++ ++ +Q + QK+ +KL
Sbjct: 320 YLLTSQLDTQRKYYEERMERLEQEWQNHKATANDAKTEVSELQQLQQNMQKEKVNLERKL 379
Query: 410 VEES--MQEMKNRLKEEMLLNSGLQQNLDH-------LTKQMEKFSLEKQKLQDENQELQ 460
+ + +++++ +L EE L+ LQ N L +Q +F KQ E EL+
Sbjct: 380 AQHTAKLKDVQKQLNEERELSKALQSNQSSWHGKYKLLEQQYNEF---KQTHDAEVTELK 436
Query: 461 SQIQDLMFHFESQEKFAEDSELQNATLV----LQPPPGSEASSSAK 502
Q++D+MF ++Q+K A ++E+ T+ +P P + + K
Sbjct: 437 EQLRDIMFFLDNQQKLA-NTEIAGGTVTGIAEKEPDPNTRRRNRRK 481
>At2g26000 [R] KOG0804 Cytoplasmic Zn-finger protein BRAP2 (BRCA1 associated
protein)
Length = 479
Score = 239 bits (610), Expect = 7e-63
Identities = 137/432 (31%), Positives = 232/432 (52%), Gaps = 66/432 (15%)
Query: 88 LGDGRMLAILFIPNYLTIN---RLLGWFIGEETTNQVTHLQLIKMNKEKGRFMLLMKFKE 144
+G ++ +L +PN++T + G FI + ++ ++ + + R+ +L++F
Sbjct: 56 IGRNPLVCVLGVPNHMTYADFCQFCGSFI-----QHILDMRTVRNDDIENRYSILIRFDS 110
Query: 145 QSLAKEFQKLFDGKKFNEIDPETCHVVAIKELIFHQGMFSEDKDALPYMLKYPFTQSSSE 204
Q F + F GK+FN +D + C + +F+ D Y TQ S+
Sbjct: 111 QESTDTFFQHFRGKQFNSLDEDVCRL-----------LFALDVQFTGYSGSIDHTQPSAA 159
Query: 205 QSDGLIELPMCPVCLEKLDSEVTGLVTTPCQHTFHCKCLDQWKNGNCPVCRYSQLKDVNN 264
G IE P CPVCLE+LD + G++TT C H+FHC C+ W + +CPVCRY Q + N+
Sbjct: 160 ---GPIEQPTCPVCLERLDQDTGGILTTMCNHSFHCSCISNWPDSSCPVCRYCQQQPENS 216
Query: 265 EPLPRCLECGETNNLWICLICGHLGCGRYNSQHAICHYEQSNHCFAMDLTTKRVWDYAGD 324
C C T NLW+C+ICG +GCGRY HA H+E++ HC++++L T+RVWDYAGD
Sbjct: 217 V----CCVCQTTENLWMCVICGVVGCGRYKEGHARRHWEETEHCYSLELETQRVWDYAGD 272
Query: 325 NYVHRIVQNEIDGKLVEVGE----SHDGSNTKRNKEYHL--------------EYVQVLL 366
NYVHR++Q++ DGKLVE+ S DG + + + EY ++L
Sbjct: 273 NYVHRLIQSKTDGKLVELNSHGSLSKDGCGSCEYSDSGMTDALLNSKVDMIISEYNELLQ 332
Query: 367 SQLESQREYYEGQIYNMHERVKSLESDMQVSRQKDDHKQLKKLVEESMQEMKNR----LK 422
+QLE+Q++Y+E + N+ E E++ ++S + K + + +Q+++ R +K
Sbjct: 333 AQLENQKQYFEKLLQNVKE-----ETEQKIS------EAASKAISQRLQKLQTRFDRCVK 381
Query: 423 EEML---LNSGLQQNLD----HLTKQMEKFSLEKQKLQDENQELQSQIQDLMFHFESQEK 475
E+ LN L +N D +T+ E+ + ++ Q L+ Q+ +LM + + +
Sbjct: 382 EKQFLEDLNENLVKNKDVWSTKITEMKEREKKAVRAKDEKIQGLEEQLGNLMAQMDGESE 441
Query: 476 FAEDSELQNATL 487
+E E+Q+AT+
Sbjct: 442 VSETKEVQDATV 453
>CE28903 [R] KOG0804 Cytoplasmic Zn-finger protein BRAP2 (BRCA1 associated
protein)
Length = 590
Score = 237 bits (605), Expect = 3e-62
Identities = 143/448 (31%), Positives = 239/448 (52%), Gaps = 69/448 (15%)
Query: 79 FDDKELYRELGDGRMLAILFIPNYLTINRLLGWFIGEETTNQVTHLQLIKMNKEKGRFML 138
++D++L + + RML + +P + + ++ + + + +++++ + ++ML
Sbjct: 145 YNDEKLTK-VAQCRMLCMYAVPAQVEVREIISFMC--ISLPMIVSIKVVR-DPAPNQYML 200
Query: 139 LMKFKEQSLAKEFQKLFDGKKFNEIDPETCHVVAIK--ELIFHQGMFSEDKDALPYMLKY 196
++KFKE + A F + F+ FN+++ C + + E +FS D +L
Sbjct: 201 IIKFKEHNDAVTFYEEFNNCPFNDLESYCCTLFFVDRIECTTSNDLFSSDDTSLT----- 255
Query: 197 PFTQSSSEQSDGLIELPMCPVCLEKLDSEVTGLVTTPCQHTFHCKCLDQWKNGNCPVCRY 256
ELP C VCLE++D V ++ C H+FH +CL+QW + CPVCRY
Sbjct: 256 --------------ELPTCAVCLERMDDSVLAIL---CNHSFHARCLEQWADNTCPVCRY 298
Query: 257 SQLKDVNNEPLPRCLECGETNNLWICLICGHLGCGRYNSQHAICHYEQSNHCFAMDLTTK 316
Q +V E RC +CG +N+LWICLICG++GCGRY QHA H+E ++H +++ + +
Sbjct: 299 VQSPEVVAEQ--RCNDCGMSNDLWICLICGNIGCGRYAEQHAQRHWELTSHTYSLKVGGE 356
Query: 317 RVWDYAGDNYVHRIVQNEIDGKLVEVGESHDGSNTKRNKE-------YHLEYVQVLLSQL 369
RVWDYAGDNYVHR+++N DGKLVE + S +N++ LEY +L SQL
Sbjct: 357 RVWDYAGDNYVHRLIENGADGKLVEYQRESNASFDDKNQKGGDKLEGIKLEYTLLLTSQL 416
Query: 370 ESQREYYEGQIYNMHERVKSLES---------DMQVSRQKDDHKQLK----------KLV 410
E QR+Y+EG ++M + + +E + Q++ + + K LK K+
Sbjct: 417 EDQRKYFEGLRHDMEQTMSKMEKTAYAQVENLEHQLTERSTELKSLKGDLDDTVTARKVA 476
Query: 411 E-------ESMQEMKNRLKEEMLLNSGLQQNLDHLTKQMEKFSLEKQK-----LQDENQE 458
E E + ++ N LK+E +N L+++ Q+EK +E QK + + ++
Sbjct: 477 EKRATQTNEKVNKLANELKDEREINQMLRKDQQVWKGQVEKL-IESQKTARTEYEKKIED 535
Query: 459 LQSQIQDLMFHFESQEKFAEDSELQNAT 486
LQSQ+ DL+ HFE+Q K E + T
Sbjct: 536 LQSQVNDLLMHFETQNKLKEQLDAGKIT 563
>At2g42160 [R] KOG0804 Cytoplasmic Zn-finger protein BRAP2 (BRCA1 associated
protein)
Length = 506
Score = 219 bits (557), Expect = 1e-56
Identities = 137/491 (27%), Positives = 243/491 (48%), Gaps = 94/491 (19%)
Query: 64 GIIRLF-KNGHASVGTFDDKELYRELGDGRMLAILFIPNYLTINRLLGWFIGEETTNQVT 122
G+I L+ K+ H+S+ + L I+ +PNYL+ + + + +QV+
Sbjct: 49 GLIHLYRKSSHSSLPNPSSRST--------TLFIVAVPNYLSSLDFIRFC--DSRISQVS 98
Query: 123 HLQLIKMNKEKGRFMLLMKFKEQSLAKEFQKLFDGKKFNEIDPETCHVVAIKELIFHQGM 182
+ I+ + + R+ +L+ F +QS A F +GKKF + E CH++ + + +
Sbjct: 99 DILFIRNDGMEDRYSVLITFSDQSEADGFYNNLNGKKFAPSEAEVCHILYVMSVEHTE-- 156
Query: 183 FSEDKDALPYMLKYPFTQSSSEQSDGLIELPMCPVCLEKLDSEVTGLVTTPCQHTFHCKC 242
F + ++E G ELP CP+CLE+LD + +G+V+T C H+F C C
Sbjct: 157 ---------------FDEVAAEAPTGFTELPTCPICLERLDPDTSGIVSTLCDHSFQCSC 201
Query: 243 LDQWKNGNCPVCRYSQLKDVNNEPLPRCLECGETNNLWICLICGHLGCGRYNSQHAICHY 302
+W +C VCR Q +D + C CG+T N+W CL+CG +GCGRY H+I H+
Sbjct: 202 TSKWTYLSCQVCRLCQQQD----EILNCSICGKTENVWACLVCGFVGCGRYKEGHSIRHW 257
Query: 303 EQSNHCFAMDLTTKRVWDYAGDNYVHRIVQNEIDGKLVEVGE---SHDGS---------- 349
++++HC+++DL T+++WDY GD+YVHR+ ++IDGK VE+ SH G
Sbjct: 258 KETHHCYSLDLRTQQIWDYVGDSYVHRLNHSKIDGKSVEMSTSCLSHQGDCGLCECSEDT 317
Query: 350 -------NTKRNKEYHL-----------------EYVQVLLSQLESQREYYEGQIYNMHE 385
N+K + +L EY +L SQL+ QR+YYE I
Sbjct: 318 GISGAIFNSKVDSNMNLRSSVCLSGFIFVEQIVIEYNDLLASQLKGQRQYYESLIVEARS 377
Query: 386 RVKSLESDMQVSRQKDDHKQLKKLVEESMQEMKNRLKEEMLLNSGLQQNLDHLTKQMEKF 445
+ +S ++ ++++V +MQE++N++++ SG+ + L K+ + +
Sbjct: 378 KQESSIAE-----------AVEQIVVNTMQELQNKIEKCEEEKSGITEVNTKLIKEQDTW 426
Query: 446 SLEKQKLQDEN-----------QELQSQIQDLMFHFESQ---EKFAEDSELQNATLVLQP 491
+ +++++ +LQ QI+D+ E++ +K + D++ VL
Sbjct: 427 RKKAKEIEEREAALLGSKDEMITDLQEQIRDITVFIEAKKTLKKMSSDTDGIREGTVLPV 486
Query: 492 PPGSEASSSAK 502
P E SS +
Sbjct: 487 PISPEPVSSVR 497
>Hs14149817 [O] KOG1867 Ubiquitin-specific protease
Length = 712
Score = 64.7 bits (156), Expect = 3e-10
Identities = 23/58 (39%), Positives = 39/58 (66%)
Query: 270 CLECGETNNLWICLICGHLGCGRYNSQHAICHYEQSNHCFAMDLTTKRVWDYAGDNYV 327
C++C T ++W CL C H+ CGRY +HA+ H+++S+H A+++ V+ Y D+YV
Sbjct: 29 CVDCNTTESIWACLSCSHVACGRYIEEHALKHFQESSHPVALEVNEMYVFCYLCDDYV 86
>Hs21361749 [O] KOG1867 Ubiquitin-specific protease
Length = 640
Score = 63.2 bits (152), Expect = 9e-10
Identities = 25/58 (43%), Positives = 36/58 (61%)
Query: 270 CLECGETNNLWICLICGHLGCGRYNSQHAICHYEQSNHCFAMDLTTKRVWDYAGDNYV 327
CLEC T ++W CL C H+ CGRY HA+ H+E++ H AM++ V+ Y +YV
Sbjct: 26 CLECATTESVWACLKCSHVACGRYIEDHALKHFEETGHPLAMEVRDLYVFCYLCKDYV 83
>CE25887 [B] KOG1343 Histone deacetylase complex catalytic component HDA1
Length = 955
Score = 58.9 bits (141), Expect = 2e-08
Identities = 30/85 (35%), Positives = 43/85 (50%), Gaps = 10/85 (11%)
Query: 252 PVCRYSQLKDVNNEPLP--------RCLECGETNNLWICLICGHLGCGRYNSQHAICHYE 303
P+ LK+V +PLP C EC +W CL C CGR+ ++HA+ H+
Sbjct: 851 PLATCPHLKEV--KPLPPAKINARTACSECQIGAEVWTCLTCYKYNCGRFVNEHAMMHHL 908
Query: 304 QSNHCFAMDLTTKRVWDYAGDNYVH 328
S+H A+ + VW Y D+YVH
Sbjct: 909 SSSHPMALSMADLSVWCYPCDSYVH 933
>Hs5454156 [O] KOG1873 Ubiquitin-specific protease
Length = 823
Score = 58.2 bits (139), Expect = 3e-08
Identities = 39/132 (29%), Positives = 61/132 (45%), Gaps = 7/132 (5%)
Query: 272 ECGETNNLWICLICGHLGCGRYN-SQHAICHY---EQSNHCFAMDLTTKRVWDYAGDNYV 327
E E ++W+CL CGH GCGR + QHA+ HY HC + L VW Y DN V
Sbjct: 64 ETEEKPSVWLCLKCGHQGCGRNSQEQHALKHYLTPRSEPHCLVLSLDNWSVWCYVCDNEV 123
Query: 328 HRIVQNEIDGKLVEVGESHDGSNTKRNKEYHLEYVQVLLSQL--ESQREYYEGQIYNMHE 385
N++ G++V+ T + E +++ +L ES+ E + NM +
Sbjct: 124 QYCSSNQL-GQVVDYVRKQASITTPKPAEKDNGNIELENKKLEKESKNEQEREKKENMAK 182
Query: 386 RVKSLESDMQVS 397
+ S Q++
Sbjct: 183 ENPPMNSPCQIT 194
>At4g11680 [O] KOG0800 FOG: Predicted E3 ubiquitin ligase
Length = 419
Score = 55.1 bits (131), Expect = 3e-07
Identities = 25/59 (42%), Positives = 36/59 (60%), Gaps = 3/59 (5%)
Query: 209 LIELPMCPVCLEKLDSEVTGLVTTPCQHTFHCKCLDQWK--NGNCPVCRYSQLKDVNNE 265
L+ L C +CL + + V L PC H FHC C+D+W N CP+C+++ LK+ NNE
Sbjct: 361 LMILQECCICLCEYEDGVE-LRELPCNHHFHCTCIDKWLHINSRCPLCKFNILKNANNE 418
>At1g72220 [O] KOG0800 FOG: Predicted E3 ubiquitin ligase
Length = 413
Score = 54.7 bits (130), Expect = 3e-07
Identities = 22/54 (40%), Positives = 32/54 (58%), Gaps = 2/54 (3%)
Query: 204 EQSDGLIELPMCPVCLEKLDSEVTGLVTTPCQHTFHCKCLDQW--KNGNCPVCR 255
++ DGLIE CPVCL + + + + + C H FH C+D W + NCP+CR
Sbjct: 166 KRGDGLIERTDCPVCLNEFEEDESLRLLPKCNHAFHISCIDTWLSSHTNCPLCR 219
>At3g58720 [O] KOG0800 FOG: Predicted E3 ubiquitin ligase
Length = 238
Score = 53.1 bits (126), Expect = 1e-06
Identities = 30/84 (35%), Positives = 45/84 (52%), Gaps = 5/84 (5%)
Query: 189 ALPYMLKYPFTQSS--SEQSDGLIELPMCPVCLEKLDSEVTGLVTTPCQHTFHCKCLDQW 246
+L Y K P ++SS ++ G + C VCLE + + T ++ TPC+H FH +C+ W
Sbjct: 116 SLYYRNKNPGSESSRNTQNLSGEEDDKRCSVCLEDFEPKET-VMLTPCKHMFHEECIVPW 174
Query: 247 --KNGNCPVCRYSQLKDVNNEPLP 268
G CPVCR+ LK + P
Sbjct: 175 LKTKGQCPVCRFVILKPTKQDSSP 198
>At1g63170 [O] KOG0800 FOG: Predicted E3 ubiquitin ligase
Length = 381
Score = 53.1 bits (126), Expect = 1e-06
Identities = 24/53 (45%), Positives = 31/53 (58%), Gaps = 3/53 (5%)
Query: 215 CPVCLEKLDSEVTGLVTTPCQHTFHCKCLDQWK--NGNCPVCRYSQLKDVNNE 265
C +CL + E T L PC H FHC C+D+W N CP+C+Y+ LK N E
Sbjct: 325 CCICLSAYEDE-TELRELPCGHHFHCGCVDKWLYINATCPLCKYNILKSSNYE 376
>Hs14249724 [O] KOG1873 Ubiquitin-specific protease
Length = 289
Score = 51.6 bits (122), Expect = 3e-06
Identities = 23/75 (30%), Positives = 44/75 (58%), Gaps = 4/75 (5%)
Query: 276 TNNLWICLICGHLGCGRYN-SQHAICHYEQSN---HCFAMDLTTKRVWDYAGDNYVHRIV 331
T+++W+CL CG GCG+ + SQH++ H++ S HC ++L+T +W Y D +
Sbjct: 79 TSDIWLCLKCGFQGCGKNSESQHSLKHFKSSRTEPHCIIINLSTWIIWCYECDEKLSTHC 138
Query: 332 QNEIDGKLVEVGESH 346
++ ++V+ + H
Sbjct: 139 NKKVLAQIVDFLQKH 153
>At3g16720 [O] KOG0800 FOG: Predicted E3 ubiquitin ligase
Length = 304
Score = 51.2 bits (121), Expect = 4e-06
Identities = 20/43 (46%), Positives = 25/43 (57%), Gaps = 2/43 (4%)
Query: 215 CPVCLEKLDSEVTGLVTTPCQHTFHCKCLDQW--KNGNCPVCR 255
C VCL + + TG V CQHTFH C+D W + CP+CR
Sbjct: 119 CAVCLSEFEESETGRVLPNCQHTFHVDCIDMWFHSHSTCPLCR 161
>HsM18874088 [O] KOG1870 Ubiquitin C-terminal hydrolase
Length = 942
Score = 50.8 bits (120), Expect = 5e-06
Identities = 24/66 (36%), Positives = 37/66 (55%), Gaps = 3/66 (4%)
Query: 260 KDVNNEPLPRCLECG-ETNNLWICLI--CGHLGCGRYNSQHAICHYEQSNHCFAMDLTTK 316
+D+ + L C +C + NLW CL C ++GCG H+ H +++ H ++LTT
Sbjct: 51 EDLIQKSLGTCQDCKVQGPNLWACLENRCSYVGCGESQVDHSTIHSQETKHYLTVNLTTL 110
Query: 317 RVWDYA 322
RVW YA
Sbjct: 111 RVWCYA 116
>Hs21489975 [O] KOG1870 Ubiquitin C-terminal hydrolase
Length = 911
Score = 50.8 bits (120), Expect = 5e-06
Identities = 24/66 (36%), Positives = 37/66 (55%), Gaps = 3/66 (4%)
Query: 260 KDVNNEPLPRCLECG-ETNNLWICLI--CGHLGCGRYNSQHAICHYEQSNHCFAMDLTTK 316
+D+ + L C +C + NLW CL C ++GCG H+ H +++ H ++LTT
Sbjct: 20 EDLIQKSLGTCQDCKVQGPNLWACLENRCSYVGCGESQVDHSTIHSQETKHYLTVNLTTL 79
Query: 317 RVWDYA 322
RVW YA
Sbjct: 80 RVWCYA 85
>YBR058c [O] KOG0944 Ubiquitin-specific protease UBP14
Length = 803
Score = 50.4 bits (119), Expect = 6e-06
Identities = 32/88 (36%), Positives = 44/88 (49%), Gaps = 13/88 (14%)
Query: 251 CPVCRYSQL--KDVNNEPLPRCLECGETNNLWICLICGHLGCGRY-----NSQHAICHY- 302
CP Q+ K N L +C C T NLW+CL CG++GCGR HA+ HY
Sbjct: 193 CPHTENFQIPSKPENTVNLNQCSSCDLTQNLWLCLHCGNIGCGREQIGIDGHSHALDHYR 252
Query: 303 EQSNHCFAMDL-----TTKRVWDYAGDN 325
+NH A+ L +T ++ YA D+
Sbjct: 253 SNNNHPLAIKLGSLSSSTYDLYCYACDD 280
>CE26241 [O] KOG1867 Ubiquitin-specific protease
Length = 664
Score = 50.4 bits (119), Expect = 6e-06
Identities = 24/70 (34%), Positives = 41/70 (58%), Gaps = 2/70 (2%)
Query: 260 KDVNNEPLPR--CLECGETNNLWICLICGHLGCGRYNSQHAICHYEQSNHCFAMDLTTKR 317
K V N+ + + C EC N +CL CG + CGR +S HA+ H+E+++H +D +
Sbjct: 41 KVVKNQEIIKTFCDECDNCNKSLMCLTCGRILCGRNDSGHALHHFEETSHPVVIDCISFE 100
Query: 318 VWDYAGDNYV 327
++ Y+ D+ V
Sbjct: 101 LYCYSCDDEV 110
>At1g12760 [O] KOG0800 FOG: Predicted E3 ubiquitin ligase
Length = 368
Score = 50.4 bits (119), Expect = 6e-06
Identities = 22/51 (43%), Positives = 30/51 (58%), Gaps = 3/51 (5%)
Query: 215 CPVCLEKLDSEVTGLVTTPCQHTFHCKCLDQWK--NGNCPVCRYSQLKDVN 263
C +CL + + T L PC H FHC C+D+W N CP+C+Y+ LK N
Sbjct: 313 CCICLSAYE-DGTELRELPCGHHFHCSCVDKWLYINATCPLCKYNILKSSN 362
>At1g26800 [O] KOG0800 FOG: Predicted E3 ubiquitin ligase
Length = 204
Score = 50.1 bits (118), Expect = 8e-06
Identities = 25/69 (36%), Positives = 38/69 (54%), Gaps = 7/69 (10%)
Query: 215 CPVCLEKLDSEVTGLVTTPCQHTFHCKCLDQWK--NGNCPVCRYSQLKDVNNEPLPRCLE 272
C +CLE+ SE T + PC+H FH C+++W +G+CPVCRY D + R
Sbjct: 113 CVICLEEWKSEET-VKEMPCKHRFHGGCIEKWLGFHGSCPVCRYEMPVDGDEIGKKR--- 168
Query: 273 CGETNNLWI 281
+ N +W+
Sbjct: 169 -NDGNEIWV 176
>7299505 [O] KOG0800 FOG: Predicted E3 ubiquitin ligase
Length = 1256
Score = 50.1 bits (118), Expect = 8e-06
Identities = 29/87 (33%), Positives = 46/87 (52%), Gaps = 12/87 (13%)
Query: 186 DKDALPYMLKYPFTQSSSEQSDGLIELPMCPVCLE--KLDSEVTGLVTTPCQHTFHCKCL 243
+++ LP+ KY + SE + + C +CL ++++EV L PC H FH C+
Sbjct: 1163 ERNTLPH--KYRRVRRPSETDE---DAEKCAICLNLFEIENEVRRL---PCMHLFHTDCV 1214
Query: 244 DQW--KNGNCPVCRYSQLKDVNNEPLP 268
DQW N +CP+CR + N+ LP
Sbjct: 1215 DQWLVTNKHCPICRVDIETHMPNDALP 1241
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.318 0.134 0.402
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,049,230
Number of Sequences: 60738
Number of extensions: 1462387
Number of successful extensions: 8525
Number of sequences better than 1.0e-05: 24
Number of HSP's better than 0.0 without gapping: 11
Number of HSP's successfully gapped in prelim test: 13
Number of HSP's that attempted gapping in prelim test: 8464
Number of HSP's gapped (non-prelim): 32
length of query: 517
length of database: 30,389,216
effective HSP length: 111
effective length of query: 406
effective length of database: 23,647,298
effective search space: 9600802988
effective search space used: 9600802988
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)