ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactVI6920 good C KOG1494 Energy production and conversion NAD-dependent malate dehydrogenase
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactVI6920 2409591 2410604 338
(338 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YKL085w [C] KOG1494 NAD-dependent malate dehydrogenase 502 e-142
SPCC306.08c [C] KOG1494 NAD-dependent malate dehydrogenase 362 e-100
CE09512 [C] KOG1494 NAD-dependent malate dehydrogenase 323 3e-88
7300357 [C] KOG1494 NAD-dependent malate dehydrogenase 315 6e-86
HsM5174541 [C] KOG1494 NAD-dependent malate dehydrogenase 301 9e-82
Hs21735621 [C] KOG1494 NAD-dependent malate dehydrogenase 301 9e-82
At3g47520 [C] KOG1494 NAD-dependent malate dehydrogenase 299 3e-81
At3g15020 [C] KOG1494 NAD-dependent malate dehydrogenase 298 1e-80
At5g09660 [C] KOG1494 NAD-dependent malate dehydrogenase 295 5e-80
At2g22780 [C] KOG1494 NAD-dependent malate dehydrogenase 295 5e-80
At1g53240 [C] KOG1494 NAD-dependent malate dehydrogenase 294 1e-79
YDL078c [C] KOG1494 NAD-dependent malate dehydrogenase 266 3e-71
7294520 [C] KOG1494 NAD-dependent malate dehydrogenase 258 1e-68
7294521 [C] KOG1494 NAD-dependent malate dehydrogenase 257 2e-68
YOL126c [C] KOG1494 NAD-dependent malate dehydrogenase 219 6e-57
SPAC186.08c [C] KOG1495 Lactate dehydrogenase 75 1e-13
At4g17260 [C] KOG1495 Lactate dehydrogenase 58 2e-08
Hs4504973 [C] KOG1495 Lactate dehydrogenase 56 9e-08
>YKL085w [C] KOG1494 NAD-dependent malate dehydrogenase
Length = 334
Score = 502 bits (1292), Expect = e-142
Identities = 256/335 (76%), Positives = 284/335 (84%), Gaps = 4/335 (1%)
Query: 1 MLRSIARRQFSSTAFNPYKVTVLGAGGGIGQPLSLLLKLNHKVTDLRLYDLKGAKGVAAD 60
ML +A+R FSST NPYKVTVLGAGGGIGQPLSLLLKLNHKVTDLRLYDLKGAKGVA D
Sbjct: 1 MLSRVAKRAFSSTVANPYKVTVLGAGGGIGQPLSLLLKLNHKVTDLRLYDLKGAKGVATD 60
Query: 61 LSHIPTNSTVTGFTPESKESQAELAAALKDTEVVLIPAGVPRKPGMTRDDLFSINAGIVR 120
LSHIPTNS V GFTPE + L ALKDT++VLIPAGVPRKPGMTRDDLF+INA IVR
Sbjct: 61 LSHIPTNSVVKGFTPEEPDG---LNNALKDTDMVLIPAGVPRKPGMTRDDLFAINASIVR 117
Query: 121 DLXXXXXXXXXXXXXLVISNPVNSTVPIVAEVLKQNGVYNPKKLFGVTTLDVIRSSRFIS 180
DL LVISNPVNSTVPIVA+VLK GVYNPKKLFGVTTLD IR++RFIS
Sbjct: 118 DLAAATAESAPNAAILVISNPVNSTVPIVAQVLKNKGVYNPKKLFGVTTLDSIRAARFIS 177
Query: 181 EIRNTDPTTERVTVVGGHSGITILPLISQTKHKSMIQGETLDKLVHRIQFGGDEVVQAKN 240
E+ NTDPT ERV V+GGHSGITI+PLISQT HK ++ + +L+HRIQFGGDEVV+AKN
Sbjct: 178 EVENTDPTQERVNVIGGHSGITIIPLISQTNHK-LMSDDKRHELIHRIQFGGDEVVKAKN 236
Query: 241 GAGSATLSMAEAGARFANSVLAGFEGERDVVESTFVDSPLYKSEGIEFFASPVTLGPEGV 300
GAGSATLSMA AGA+FAN+VL+GF+GERDV+E +FVDSPL+KSEGIEFFASPVTLGP+G+
Sbjct: 237 GAGSATLSMAHAGAKFANAVLSGFKGERDVIEPSFVDSPLFKSEGIEFFASPVTLGPDGI 296
Query: 301 EKIHGIGALSEKEEEMLAKCKETLKKNIEKGQKFV 335
EKIH IG LS +EEEML KCKETLKKNIEKG FV
Sbjct: 297 EKIHPIGELSSEEEEMLQKCKETLKKNIEKGVNFV 331
>SPCC306.08c [C] KOG1494 NAD-dependent malate dehydrogenase
Length = 341
Score = 362 bits (930), Expect = e-100
Identities = 193/334 (57%), Positives = 240/334 (71%), Gaps = 6/334 (1%)
Query: 2 LRSIARRQFSSTAFNPYKVTVLGAGGGIGQPLSLLLKLNHKVTDLRLYDLKGAKGVAADL 61
L+SIA R FS+T+ +KV VLGAGGGIGQPLS+LLKLN KV++L L+D++GA GVAAD+
Sbjct: 13 LKSIAPRSFSTTSSRAFKVAVLGAGGGIGQPLSMLLKLNDKVSELALFDIRGAPGVAADI 72
Query: 62 SHIPTNSTVTGFTPESKESQAELAAALKDTEVVLIPAGVPRKPGMTRDDLFSINAGIVRD 121
HI T S V G+ P+ K L AL +VV+IPAGVPRKPGMTRDDLF+ NA IVRD
Sbjct: 73 GHINTTSNVVGYAPDDKG----LEKALNGADVVIIPAGVPRKPGMTRDDLFATNASIVRD 128
Query: 122 LXXXXXXXXXXXXXLVISNPVNSTVPIVAEVLKQNGVYNPKKLFGVTTLDVIRSSRFISE 181
L LV++NPVNSTVPI + L++ GV+ PK LFGVTTLD +R+SRF S+
Sbjct: 129 LAFAAGETCPEAKYLVVTNPVNSTVPIFKKALERVGVHQPKHLFGVTTLDSVRASRFTSQ 188
Query: 182 IRNTDPTTERVTVVGGHSGITILPLISQTKHKSMIQGETLDKLVHRIQFGGDEVVQAKNG 241
+ N + VVGGHSG TI+PL+SQ + + GE D L+HRIQFGGDEVV+AK G
Sbjct: 189 VTNGKAELLHIPVVGGHSGATIVPLLSQGGVE--LTGEKRDALIHRIQFGGDEVVKAKAG 246
Query: 242 AGSATLSMAEAGARFANSVLAGFEGERDVVESTFVDSPLYKSEGIEFFASPVTLGPEGVE 301
AGSATLSMA AGAR A+SVL GE V E TFV+SPLYK +GI+FFAS VTLG +GV+
Sbjct: 247 AGSATLSMAYAGARMASSVLRALAGESGVEECTFVESPLYKDQGIDFFASRVTLGKDGVD 306
Query: 302 KIHGIGALSEKEEEMLAKCKETLKKNIEKGQKFV 335
IH +G +++ EE +L LKK+I KG++FV
Sbjct: 307 TIHPVGKINDYEESLLKVALGELKKSITKGEQFV 340
>CE09512 [C] KOG1494 NAD-dependent malate dehydrogenase
Length = 341
Score = 323 bits (827), Expect = 3e-88
Identities = 179/337 (53%), Positives = 229/337 (67%), Gaps = 12/337 (3%)
Query: 2 LRSIARRQFSSTAFNPYKVTVLGAGGGIGQPLSLLLKLNHKVTDLRLYDLKGAKGVAADL 61
LR+++ R S KV +LGA GGIGQPL LLLK + V L LYD+ GVAADL
Sbjct: 17 LRAVSVRHSSQAP----KVALLGAAGGIGQPLGLLLKQDPLVAHLALYDVVNTPGVAADL 72
Query: 62 SHIPTNSTVTGFTPESKESQAELAAALKDTEVVLIPAGVPRKPGMTRDDLFSINAGIVRD 121
SHI +N+ VT T EL AA+++ +V++IPAGVPRKPGMTRDDLF+ NAGIVRD
Sbjct: 73 SHIDSNAKVTAHT-----GPKELYAAVENADVIVIPAGVPRKPGMTRDDLFNTNAGIVRD 127
Query: 122 LXXXXXXXXXXXXXLVISNPVNSTVPIVAEVLKQNGVYNPKKLFGVTTLDVIRSSRFISE 181
L +I+NPVNSTVPI +EVLK+ GVY+PK++FGVTTLDV+RS F+SE
Sbjct: 128 LAAVIAKASPKALIAIITNPVNSTVPIASEVLKKAGVYDPKRVFGVTTLDVVRSQAFVSE 187
Query: 182 IRNTDPTTERVTVVGGHSGITILPLISQTKHKSMIQGETLDKLVHRIQFGGDEVVQAKNG 241
++ D + V VVGGH+GITI+PL+SQ K + E + KL RIQ G EVV AK G
Sbjct: 188 LKGHDASKTVVPVVGGHAGITIIPLLSQVKPSTKFSEEEISKLTPRIQDAGTEVVNAKAG 247
Query: 242 AGSATLSMAEAGARFANSVLAGFEGERDVVESTFVDSPLYKSEGIEFFASPVTLGPEGVE 301
AGSATLSMA AGARFAN+++ G +GE++ V+ +V S K G+E+F++PV LGP GVE
Sbjct: 248 AGSATLSMALAGARFANALVRGIKGEKN-VQCAYVASDAVK--GVEYFSTPVELGPNGVE 304
Query: 302 KIHGIGALSEKEEEMLAKCKETLKKNIEKGQKFVTGN 338
KI G+G +S E++++ L KNI KG FV GN
Sbjct: 305 KILGVGKVSAYEQKLIDASVPELNKNIAKGVAFVKGN 341
>7300357 [C] KOG1494 NAD-dependent malate dehydrogenase
Length = 336
Score = 315 bits (807), Expect = 6e-86
Identities = 170/327 (51%), Positives = 224/327 (67%), Gaps = 8/327 (2%)
Query: 8 RQFSSTAFNPYKVTVLGAGGGIGQPLSLLLKLNHKVTDLRLYDLKGAKGVAADLSHIPTN 67
R FS N YKVTV GA GGIGQPLSLLLK N VTDL LYD+ GVAADLSHI T
Sbjct: 15 RTFSVGQQNNYKVTVCGAAGGIGQPLSLLLKQNPLVTDLALYDIVHTPGVAADLSHIDTK 74
Query: 68 STVTGFTPESKESQAELAAALKDTEVVLIPAGVPRKPGMTRDDLFSINAGIVRDLXXXXX 127
S GF +L +LK ++VV+IPAGVPRKPGMTRDDLF++NAGI++D+
Sbjct: 75 SKTAGFIGAD-----QLGDSLKGSDVVVIPAGVPRKPGMTRDDLFNVNAGIIKDISNSIA 129
Query: 128 XXXXXXXXLVISNPVNSTVPIVAEVLKQNGVYNPKKLFGVTTLDVIRSSRFISEIRNTDP 187
+I+NPVN+ VPI AE+LK+ GVY+PK+LFGV+TLDV+R+ FI DP
Sbjct: 130 KNCPKALVAIITNPVNTCVPIAAEILKKAGVYDPKRLFGVSTLDVVRARAFIGHALGVDP 189
Query: 188 TTERVTVVGGHSGITILPLISQTKHKSMIQGETLDKLVHRIQFGGDEVVQAKNGAGSATL 247
T ++ V+GGHSG+TILP++SQ++ +T++KL RIQ G EVV+AK GAGSATL
Sbjct: 190 QTVQIPVIGGHSGVTILPVLSQSQPLFKGNQDTIEKLTVRIQEAGTEVVKAKAGAGSATL 249
Query: 248 SMAEAGARFANSVLAGFEGERDVVESTFVDSPLYKSEGIEFFASPVTLGPEGVEKIHGIG 307
SMA AGARFA S+L G GE++V+E ++V S + ++ FF++P+ LG GV++ G+
Sbjct: 250 SMAYAGARFAGSLLKGLNGEKNVIECSYVQSTVTEA---TFFSTPLVLGKNGVQENLGLP 306
Query: 308 ALSEKEEEMLAKCKETLKKNIEKGQKF 334
L++ E+++L LKKNI+KG F
Sbjct: 307 KLNDYEKKLLEAAIPELKKNIQKGIDF 333
>HsM5174541 [C] KOG1494 NAD-dependent malate dehydrogenase
Length = 338
Score = 301 bits (771), Expect = 9e-82
Identities = 171/330 (51%), Positives = 218/330 (65%), Gaps = 10/330 (3%)
Query: 7 RRQFSSTAFNPYKVTVLGAGGGIGQPLSLLLKLNHKVTDLRLYDLKGAKGVAADLSHIPT 66
RR FS++A N KV VLGA GGIGQPLSLLLK + V+ L LYD+ GVAADLSHI T
Sbjct: 14 RRSFSTSAQNNAKVAVLGASGGIGQPLSLLLKNSPLVSRLTLYDIAHTPGVAADLSHIET 73
Query: 67 NSTVTGFT-PESKESQAELAAALKDTEVVLIPAGVPRKPGMTRDDLFSINAGIVRDLXXX 125
+ V G+ PE +L LK +VV+IPAGVPRKPGMTRDDLF+ NA IV L
Sbjct: 74 KAAVKGYLGPE------QLPDCLKGCDVVVIPAGVPRKPGMTRDDLFNTNATIVATLTAA 127
Query: 126 XXXXXXXXXXLVISNPVNSTVPIVAEVLKQNGVYNPKKLFGVTTLDVIRSSRFISEIRNT 185
VI+NPVNST+PI AEV K++GVYNP K+FGVTTLD++R++ F++E++
Sbjct: 128 CAQHCPEAMICVIANPVNSTIPITAEVFKKHGVYNPNKIFGVTTLDIVRANTFVAELKGL 187
Query: 186 DPTTERVTVVGGHSGITILPLISQTKHKSMIQGETLDKLVHRIQFGGDEVVQAKNGAGSA 245
DP V V+GGH+G TI+PLISQ K + L L RIQ G EVV+AK GAGSA
Sbjct: 188 DPARVNVPVIGGHAGKTIIPLISQCTPKVDFPQDQLTALTGRIQEAGTEVVKAKAGAGSA 247
Query: 246 TLSMAEAGARFANSVLAGFEGERDVVESTFVDSPLYKSEGIEFFASPVTLGPEGVEKIHG 305
TLSMA AGARF S++ G+ VVE +FV S + +F++P+ LG +G+EK G
Sbjct: 248 TLSMAYAGARFVFSLVDAMNGKEGVVECSFVKS---QETECTYFSTPLLLGKKGIEKNLG 304
Query: 306 IGALSEKEEEMLAKCKETLKKNIEKGQKFV 335
IG +S EE+M++ LK +I+KG+ FV
Sbjct: 305 IGKVSSFEEKMISDAIPELKASIKKGEDFV 334
>Hs21735621 [C] KOG1494 NAD-dependent malate dehydrogenase
Length = 338
Score = 301 bits (771), Expect = 9e-82
Identities = 171/330 (51%), Positives = 218/330 (65%), Gaps = 10/330 (3%)
Query: 7 RRQFSSTAFNPYKVTVLGAGGGIGQPLSLLLKLNHKVTDLRLYDLKGAKGVAADLSHIPT 66
RR FS++A N KV VLGA GGIGQPLSLLLK + V+ L LYD+ GVAADLSHI T
Sbjct: 14 RRSFSTSAQNNAKVAVLGASGGIGQPLSLLLKNSPLVSRLTLYDIAHTPGVAADLSHIET 73
Query: 67 NSTVTGFT-PESKESQAELAAALKDTEVVLIPAGVPRKPGMTRDDLFSINAGIVRDLXXX 125
+ V G+ PE +L LK +VV+IPAGVPRKPGMTRDDLF+ NA IV L
Sbjct: 74 KAAVKGYLGPE------QLPDCLKGCDVVVIPAGVPRKPGMTRDDLFNTNATIVATLTAA 127
Query: 126 XXXXXXXXXXLVISNPVNSTVPIVAEVLKQNGVYNPKKLFGVTTLDVIRSSRFISEIRNT 185
VI+NPVNST+PI AEV K++GVYNP K+FGVTTLD++R++ F++E++
Sbjct: 128 CAQHCPEAMICVIANPVNSTIPITAEVFKKHGVYNPNKIFGVTTLDIVRANTFVAELKGL 187
Query: 186 DPTTERVTVVGGHSGITILPLISQTKHKSMIQGETLDKLVHRIQFGGDEVVQAKNGAGSA 245
DP V V+GGH+G TI+PLISQ K + L L RIQ G EVV+AK GAGSA
Sbjct: 188 DPARVNVPVIGGHAGKTIIPLISQCTPKVDFPQDQLTALTGRIQEAGTEVVKAKAGAGSA 247
Query: 246 TLSMAEAGARFANSVLAGFEGERDVVESTFVDSPLYKSEGIEFFASPVTLGPEGVEKIHG 305
TLSMA AGARF S++ G+ VVE +FV S + +F++P+ LG +G+EK G
Sbjct: 248 TLSMAYAGARFVFSLVDAMNGKEGVVECSFVKS---QETECTYFSTPLLLGKKGIEKNLG 304
Query: 306 IGALSEKEEEMLAKCKETLKKNIEKGQKFV 335
IG +S EE+M++ LK +I+KG+ FV
Sbjct: 305 IGKVSSFEEKMISDAIPELKASIKKGEDFV 334
>At3g47520 [C] KOG1494 NAD-dependent malate dehydrogenase
Length = 403
Score = 299 bits (766), Expect = 3e-81
Identities = 173/319 (54%), Positives = 210/319 (65%), Gaps = 10/319 (3%)
Query: 18 YKVTVLGAGGGIGQPLSLLLKLNHKVTDLRLYDLKGAKGVAADLSHIPTNSTVTGFTPES 77
YKV VLGA GGIGQPLSLL+K++ V+ L LYD+ KGVAADLSH T S V FT S
Sbjct: 83 YKVAVLGAAGGIGQPLSLLIKMSPLVSTLHLYDIANVKGVAADLSHCNTPSQVRDFTGPS 142
Query: 78 KESQAELAAALKDTEVVLIPAGVPRKPGMTRDDLFSINAGIVRDLXXXXXXXXXXXXXLV 137
ELA LKD VV+IPAGVPRKPGMTRDDLF+INA IV+ L +
Sbjct: 143 -----ELADCLKDVNVVVIPAGVPRKPGMTRDDLFNINANIVKTLVEAVAENCPNAFIHI 197
Query: 138 ISNPVNSTVPIVAEVLKQNGVYNPKKLFGVTTLDVIRSSRFISEIRNTDPTTERVTVVGG 197
ISNPVNSTVPI AEVLK+ GVY+PKKLFGVTTLDV+R++ F+S+ +N V V+GG
Sbjct: 198 ISNPVNSTVPIAAEVLKKKGVYDPKKLFGVTTLDVVRANTFVSQKKNLKLIDVDVPVIGG 257
Query: 198 HSGITILPLISQTKHKSMIQGETLDKLVHRIQFGGDEVVQAKNGAGSATLSMAEAGARFA 257
H+GITILPL+S+TK E + +L RIQ G EVV AK GAGSATLSMA A ARF
Sbjct: 258 HAGITILPLLSKTKPSVNFTDEEIQELTVRIQNAGTEVVDAKAGAGSATLSMAYAAARFV 317
Query: 258 NSVLAGFEGERDVVESTFVDSPLYKSEGIEFFASPVTLGPEGVEKI--HGIGALSEKEEE 315
S L +G+ DV E +FV+S L + FFAS V +G G+E + + L+E E++
Sbjct: 318 ESSLRALDGDGDVYECSFVESTL---TDLPFFASRVKIGKNGLEAVIESDLQGLTEYEQK 374
Query: 316 MLAKCKETLKKNIEKGQKF 334
L K LK +I+KG F
Sbjct: 375 ALEALKVELKASIDKGVAF 393
>At3g15020 [C] KOG1494 NAD-dependent malate dehydrogenase
Length = 341
Score = 298 bits (762), Expect = 1e-80
Identities = 168/332 (50%), Positives = 217/332 (64%), Gaps = 8/332 (2%)
Query: 3 RSIARRQFSSTAFNPYKVTVLGAGGGIGQPLSLLLKLNHKVTDLRLYDLKGAKGVAADLS 62
+ + RR F+S + KV +LGA GGIGQPLSLL+KLN V+ L LYD+ GVAAD+
Sbjct: 15 QGLLRRGFASESVPDRKVVILGAAGGIGQPLSLLMKLNPLVSSLSLYDIANTPGVAADVG 74
Query: 63 HIPTNSTVTGFTPESKESQAELAAALKDTEVVLIPAGVPRKPGMTRDDLFSINAGIVRDL 122
HI T S V+G+ + +L AL+ ++V+IPAGVPRKPGMTRDDLF+INAGIV++L
Sbjct: 75 HINTRSQVSGYMGDD-----DLGKALEGADLVIIPAGVPRKPGMTRDDLFNINAGIVKNL 129
Query: 123 XXXXXXXXXXXXXLVISNPVNSTVPIVAEVLKQNGVYNPKKLFGVTTLDVIRSSRFISEI 182
+ISNPVNSTVPI AE+ K+ G Y+ KKLFGVTTLDV+R+ F +
Sbjct: 130 SIAIAKYCPQALVNMISNPVNSTVPIAAEIFKKAGTYDEKKLFGVTTLDVVRARTFYAGK 189
Query: 183 RNTDPTTERVTVVGGHSGITILPLISQTKHKSMIQGETLDKLVHRIQFGGDEVVQAKNGA 242
+ + V VVGGH+GITILPL SQ ++ + + + L R Q GG EVV+AK G
Sbjct: 190 SDVNVAEVNVPVVGGHAGITILPLFSQASPQANLSDDLIRALTKRTQDGGTEVVEAKAGK 249
Query: 243 GSATLSMAEAGARFANSVLAGFEGERDVVESTFVDSPLYKSEGIEFFASPVTLGPEGVEK 302
GSATLSMA AGA FA++ L G G +VVE +FV S + + + FFAS V LG GVE+
Sbjct: 250 GSATLSMAYAGALFADACLKGLNGVPNVVECSFVQSTITE---LPFFASKVRLGKNGVEE 306
Query: 303 IHGIGALSEKEEEMLAKCKETLKKNIEKGQKF 334
+ +G LS+ E+E L K LK +IEKG KF
Sbjct: 307 VLDLGPLSDFEKEGLEALKAELKSSIEKGIKF 338
>At5g09660 [C] KOG1494 NAD-dependent malate dehydrogenase
Length = 354
Score = 295 bits (756), Expect = 5e-80
Identities = 166/332 (50%), Positives = 218/332 (65%), Gaps = 9/332 (2%)
Query: 5 IARRQFSSTAFNP-YKVTVLGAGGGIGQPLSLLLKLNHKVTDLRLYDLKGAKGVAADLSH 63
I R + NP +KV +LGA GGIGQ LSLL+K+N V+ L LYD+ A GV AD+SH
Sbjct: 29 IGRENCRAKGGNPGFKVAILGAAGGIGQSLSLLMKMNPLVSLLHLYDVVNAPGVTADVSH 88
Query: 64 IPTNSTVTGFTPESKESQAELAAALKDTEVVLIPAGVPRKPGMTRDDLFSINAGIVRDLX 123
+ T + V GF +L AL ++V+IPAG+PRKPGMTRDDLF INAGIV+ L
Sbjct: 89 MDTGAVVRGFL-----GAKQLEDALTGMDLVIIPAGIPRKPGMTRDDLFKINAGIVKTLC 143
Query: 124 XXXXXXXXXXXXLVISNPVNSTVPIVAEVLKQNGVYNPKKLFGVTTLDVIRSSRFISEIR 183
+ISNPVNSTVPI AEV K+ G Y+PKKL GVTTLDV R++ F++E+
Sbjct: 144 EGVAKCCPNAIVNLISNPVNSTVPIAAEVFKKAGTYDPKKLLGVTTLDVARANTFVAEVL 203
Query: 184 NTDPTTERVTVVGGHSGITILPLISQTKHKSMIQGETLDKLVHRIQFGGDEVVQAKNGAG 243
DP V VVGGH+G+TILPL+SQ K S + ++ L +RIQ GG EVV+AK GAG
Sbjct: 204 GLDPREVDVPVVGGHAGVTILPLLSQVKPPSSFTPQEIEYLTNRIQNGGTEVVEAKAGAG 263
Query: 244 SATLSMAEAGARFANSVLAGFEGERDVVESTFVDSPLYKSEGIEFFASPVTLGPEGVEKI 303
SATLSMA A A+FA++ L G G+ +VVE +FV S + + + FFA+ V LG G E++
Sbjct: 264 SATLSMAYAAAKFADACLRGLRGDANVVECSFVASQVTE---LAFFATKVRLGRTGAEEV 320
Query: 304 HGIGALSEKEEEMLAKCKETLKKNIEKGQKFV 335
+ +G L+E E L K K+ L +I+KG +F+
Sbjct: 321 YQLGPLNEYERIGLEKAKDELAGSIQKGVEFI 352
>At2g22780 [C] KOG1494 NAD-dependent malate dehydrogenase
Length = 354
Score = 295 bits (756), Expect = 5e-80
Identities = 159/317 (50%), Positives = 212/317 (66%), Gaps = 8/317 (2%)
Query: 18 YKVTVLGAGGGIGQPLSLLLKLNHKVTDLRLYDLKGAKGVAADLSHIPTNSTVTGFTPES 77
+KV +LGA GGIGQPL++L+K+N V+ L LYD+ A GV AD+SH+ T++ V GF
Sbjct: 43 FKVAILGAAGGIGQPLAMLMKMNPLVSVLHLYDVANAPGVTADISHMDTSAVVRGFL--- 99
Query: 78 KESQAELAAALKDTEVVLIPAGVPRKPGMTRDDLFSINAGIVRDLXXXXXXXXXXXXXLV 137
Q +L AL ++V+IPAGVPRKPGMTRDDLF+INAGIVR L +
Sbjct: 100 --GQPQLEEALTGMDLVIIPAGVPRKPGMTRDDLFNINAGIVRTLSEAIAKCCPKAIVNI 157
Query: 138 ISNPVNSTVPIVAEVLKQNGVYNPKKLFGVTTLDVIRSSRFISEIRNTDPTTERVTVVGG 197
ISNPVNSTVPI AEV K+ G ++PKKL GVT LDV+R++ F++E+ + DP V VVGG
Sbjct: 158 ISNPVNSTVPIAAEVFKKAGTFDPKKLMGVTMLDVVRANTFVAEVMSLDPREVEVPVVGG 217
Query: 198 HSGITILPLISQTKHKSMIQGETLDKLVHRIQFGGDEVVQAKNGAGSATLSMAEAGARFA 257
H+G+TILPL+SQ K + ++ L RIQ GG EVV+AK GAGSATLSMA A FA
Sbjct: 218 HAGVTILPLLSQVKPPCSFTQKEIEYLTDRIQNGGTEVVEAKAGAGSATLSMAYAAVEFA 277
Query: 258 NSVLAGFEGERDVVESTFVDSPLYKSEGIEFFASPVTLGPEGVEKIHGIGALSEKEEEML 317
++ L G G+ ++VE +V S + + + FFAS V LG G+++++G+G L+E E L
Sbjct: 278 DACLRGLRGDANIVECAYVASHVTE---LPFFASKVRLGRCGIDEVYGLGPLNEYERMGL 334
Query: 318 AKCKETLKKNIEKGQKF 334
K K+ L +I KG F
Sbjct: 335 EKAKKELSVSIHKGVTF 351
>At1g53240 [C] KOG1494 NAD-dependent malate dehydrogenase
Length = 352
Score = 294 bits (752), Expect = 1e-79
Identities = 168/343 (48%), Positives = 217/343 (62%), Gaps = 19/343 (5%)
Query: 3 RSIARRQFSSTAFNPYKVTVLGAGGGIGQPLSLLLKLNHKVTDLRLYDLKGAKGVAADLS 62
+++ RR FSS + KV +LGA GGIGQPL+LL+KLN V+ L LYD+ GVAAD+
Sbjct: 15 QAVIRRSFSSGSVPERKVAILGAAGGIGQPLALLMKLNPLVSSLSLYDIANTPGVAADVG 74
Query: 63 HIPTNSTVTGFTPESKESQAELAAALKDTEVVLIPAGVPRKPGMTRDDLFSINAGIVRDL 122
HI T S V G+ + LA AL+ ++V+IPAGVPRKPGMTRDDLF+INAGIV++L
Sbjct: 75 HINTRSEVVGYMGDDN-----LAKALEGADLVIIPAGVPRKPGMTRDDLFNINAGIVKNL 129
Query: 123 XXXXXXXXXXXXXLVISNPVNSTVPIVAEVLKQNGVYNPKKLFGVTTLDVIRSSRFISEI 182
+ISNPVNSTVPI AE+ K+ G+Y+ KKLFGVTTLDV+R+ F +
Sbjct: 130 CTAIAKYCPHALINMISNPVNSTVPIAAEIFKKAGMYDEKKLFGVTTLDVVRARTFYAGK 189
Query: 183 RNTDPTTERVTVVGGHSGITILPLISQTKH-----------KSMIQGETLDKLVHRIQFG 231
N V V+GGH+G+TILPL SQ ++ + + L L R Q G
Sbjct: 190 ANVPVAEVNVPVIGGHAGVTILPLFSQVSSHFLSTQTVATPQANLSSDILTALTKRTQDG 249
Query: 232 GDEVVQAKNGAGSATLSMAEAGARFANSVLAGFEGERDVVESTFVDSPLYKSEGIEFFAS 291
G EVV+AK G GSATLSMA AGA FA++ L G G DV+E ++V S + + + FFAS
Sbjct: 250 GTEVVEAKAGKGSATLSMAYAGALFADACLKGLNGVPDVIECSYVQSTITE---LPFFAS 306
Query: 292 PVTLGPEGVEKIHGIGALSEKEEEMLAKCKETLKKNIEKGQKF 334
V LG GVE++ +G LS+ E+E L K LK +IEKG KF
Sbjct: 307 KVRLGKNGVEEVLDLGPLSDFEKEGLEALKPELKSSIEKGVKF 349
>YDL078c [C] KOG1494 NAD-dependent malate dehydrogenase
Length = 343
Score = 266 bits (680), Expect = 3e-71
Identities = 157/344 (45%), Positives = 211/344 (60%), Gaps = 36/344 (10%)
Query: 19 KVTVLGAGGGIGQPLSLLLKLNHKVTDLRLYDLKGAKGVAADLSHIPTNSTVTGFTPESK 78
KV +LGA GG+GQPLSLLLKL+ V++L LYD++ A+G+ DLSHI TNS+ G+ +S
Sbjct: 3 KVAILGASGGVGQPLSLLLKLSPYVSELALYDIRAAEGIGKDLSHINTNSSCVGYDKDSI 62
Query: 79 ESQAELAAALKDTEVVLIPAGVPRKPGMTRDDLFSINAGIVRDLXXXXXXXXXXXXXLVI 138
E+ L + +VVLIPAGVPRKPG+TRDDLF +NAGIV+ L LVI
Sbjct: 63 EN------TLSNAQVVLIPAGVPRKPGLTRDDLFKMNAGIVKSLVTAVGKFAPNARILVI 116
Query: 139 SNPVNSTVPIVAEVLKQNGVYNPKKLFGVTTLDVIRSSRFISEI---------RNTDPTT 189
SNPVNS VPI E LK+ G + P + GVT LD++R+ F+ + + D TT
Sbjct: 117 SNPVNSLVPIAVETLKKMGKFKPGNVMGVTNLDLVRAETFLVDYLMLKNPKIGQEQDKTT 176
Query: 190 --ERVTVVGGHSGITILPLISQTKHKSMI--QGETLDKLVHRIQFGGDEVVQAKNGAGSA 245
+VTV+GGHSG TI+P+I+ KS++ + + +HR+QFGGDE+V+AK GAGSA
Sbjct: 177 MHRKVTVIGGHSGETIIPIITD---KSLVFQLDKQYEHFIHRVQFGGDEIVKAKQGAGSA 233
Query: 246 TLSMAEAGARFANSVLAGFEGERDVVE--STFVDSP----------LYKSEGIEFFASPV 293
TLSMA AGA+FA VL F E+ E S FV P L IE+F+ P+
Sbjct: 234 TLSMAFAGAKFAEEVLRSFHNEKPETESLSAFVYLPGLKNGKKAQQLVGDNSIEYFSLPI 293
Query: 294 TLGPEGVEKIHG--IGALSEKEEEMLAKCKETLKKNIEKGQKFV 335
L V I + LS +EE+++ + L+KNIEKG+ F+
Sbjct: 294 VLRNGSVVSIDTSVLEKLSPREEQLVNTAVKELRKNIEKGKSFI 337
>7294520 [C] KOG1494 NAD-dependent malate dehydrogenase
Length = 347
Score = 258 bits (658), Expect = 1e-68
Identities = 140/321 (43%), Positives = 202/321 (62%), Gaps = 10/321 (3%)
Query: 19 KVTVLGAGGGIGQPLSLLLKLNHKVTDLRLYDLKGAKGVAADLSHIPTNSTVTGFTPESK 78
KV V+G+ GGIGQPLSLLLK N +++ L LYD+K GV DLSHI T ++V F
Sbjct: 29 KVAVVGSVGGIGQPLSLLLKHNPQISTLSLYDIKNTTGVGVDLSHINTRASVCPF----- 83
Query: 79 ESQAELAAALKDTEVVLIPAGVPRKPGMTRDDLFSINAGIVRDLXXXXXXXXXXXXXLVI 138
E + L A+ ++V+IPAG+PRKPGM R+DL +NA + ++ I
Sbjct: 84 EGKNGLKKAMDKADIVVIPAGLPRKPGMKREDLVDVNASVACEVAFAASEVCPGAMLAFI 143
Query: 139 SNPVNSTVPIVAEVLKQNGVYNPKKLFGVTTLDVIRSSRFISEIRNTDPTTERVTVVGGH 198
+NP+N VPIVA +LK G Y+P +LFGVTTLDV+R+ F+++I N DP + V+GGH
Sbjct: 144 TNPINVIVPIVATILKAKGTYDPNRLFGVTTLDVVRAQTFVADILNVDPQKVNIPVIGGH 203
Query: 199 SGITILPLISQTKHKSMIQGETLDKLVHRIQFGGDEVVQAKNGAGSATLSMAEAGARFAN 258
+G TILP++SQ + + L+ RIQ G EVV AK+G GSATLSMA A +F +
Sbjct: 204 TGRTILPILSQCDPPFKGTDKEREALIQRIQNAGTEVVNAKDGLGSATLSMAFAATQFVS 263
Query: 259 SVLAGFEGERD--VVESTFVDSPLYKSEGIEFFASPVTLGPEGVEKIHGIGALSEKEEEM 316
S++ G +G +D +VE +V+S + ++ +FFA+P+ LGP+GV++ G+ L ++E +
Sbjct: 264 SLIKGIKGSKDECIVECAYVESDVTEA---QFFATPLILGPQGVKENTGLPDLDDEERKA 320
Query: 317 LAKCKETLKKNIEKGQKFVTG 337
L LK++I KG K G
Sbjct: 321 LNGMLPILKESIAKGIKLGEG 341
>7294521 [C] KOG1494 NAD-dependent malate dehydrogenase
Length = 349
Score = 257 bits (656), Expect = 2e-68
Identities = 144/333 (43%), Positives = 196/333 (58%), Gaps = 8/333 (2%)
Query: 2 LRSIARRQFSSTAFNPYKVTVLGAGGGIGQPLSLLLKLNHKVTDLRLYDLKGAKGVAADL 61
L+S+A+ KV V+GAGGGIGQPLSLLL+ + +L L+DL KG+A DL
Sbjct: 7 LKSLAKPATWGVVVRTLKVAVVGAGGGIGQPLSLLLRRCPGIDELALHDLSEMKGIATDL 66
Query: 62 SHIPTNSTVTGFTPESKESQAELAAALKDTEVVLIPAGVPRKPGMTRDDLFSINAGIVRD 121
SHI V GFT E EL +A+ +VV++ AG+PR PGM RD L + N +
Sbjct: 67 SHISQTGKVIGFTGEK-----ELESAVSGADVVVVAAGMPRLPGMQRDHLMAANGNVAVK 121
Query: 122 LXXXXXXXXXXXXXLVISNPVNSTVPIVAEVLKQNGVYNPKKLFGVTTLDVIRSSRFISE 181
+ I+NPVN VP AEVL +G ++ ++LFG+TTLDV+RS +FI +
Sbjct: 122 VATAISNASPRAHLAFITNPVNMIVPAAAEVLMAHGTFDSRRLFGITTLDVVRSKKFIGD 181
Query: 182 IRNTDPTTERVTVVGGHSGITILPLISQTKHKSMIQGETLDKLVHRIQFGGDEVVQAKNG 241
N P + V+GGH+GITILPLISQ + + + L HRIQ G EVV AK G
Sbjct: 182 SMNISPDDVNIPVIGGHAGITILPLISQCQPIYRCDLQEIQNLTHRIQEAGTEVVNAKAG 241
Query: 242 AGSATLSMAEAGARFANSVLAGFEGERDVVESTFVDSPLYKSEGIEFFASPVTLGPEGVE 301
GSATLSMA AGA F NS+L G G+ ++E FV S L + FFASP+ LG +G++
Sbjct: 242 KGSATLSMAYAGATFVNSLLRGIAGQDGLIECAFVASKLTDA---PFFASPLELGKDGIK 298
Query: 302 KIHGIGALSEKEEEMLAKCKETLKKNIEKGQKF 334
+ + +S+ E+E L K L++N ++G F
Sbjct: 299 RYIPLPQMSDYEKEALEKLLPILRQNADEGVNF 331
>YOL126c [C] KOG1494 NAD-dependent malate dehydrogenase
Length = 423
Score = 219 bits (557), Expect = 6e-57
Identities = 144/361 (39%), Positives = 199/361 (54%), Gaps = 49/361 (13%)
Query: 19 KVTVLGAGGGIGQPLSLLLKL---------NHKVTD--LRLYDL--KGAKGVAADLSHIP 65
K+ +LGA GGIGQ LSLLLK N VT L LYD+ + GV ADLSHI
Sbjct: 61 KIAILGAAGGIGQSLSLLLKAQLQYQLKESNRSVTHIHLALYDVNQEAINGVTADLSHID 120
Query: 66 TNSTVTGFTPESKESQAELAAALKDTEVVLIPAGVPRKPGMTRDDLFSINAGIVRDLXXX 125
T +V+ +P + L + +V+IPAGVPRKPGMTRDDLF++NAGI+ L
Sbjct: 121 TPISVSSHSPAGG-----IENCLHNASIVVIPAGVPRKPGMTRDDLFNVNAGIISQLGDS 175
Query: 126 XXX--XXXXXXXLVISNPVNSTVPIVAEVLKQNGVYN-----PKKLFGVTTLDVIRSSRF 178
LVISNPVNS VP++ + +N + +++ GVT LD++R+S F
Sbjct: 176 IAECCDLSKVFVLVISNPVNSLVPVMVSNILKNHPQSRNSGIERRIMGVTKLDIVRASTF 235
Query: 179 ISEIRNTDPTTERVT------VVGGHSGITILPLISQTKHKSMIQGETLDKLVHRIQFGG 232
+ EI T RV V+GGHSG TI+PL SQ+ S + + L L+HR+Q+GG
Sbjct: 236 LREINIESGLTPRVNSMPDVPVIGGHSGETIIPLFSQSNFLSRLNEDQLKYLIHRVQYGG 295
Query: 233 DEVVQAKNGAGSATLSMAEAGARFANSVLAGFEGERDVVESTF---------------VD 277
DEVV+AKNG GSATLSMA AG + ++ G + + T+ D
Sbjct: 296 DEVVKAKNGKGSATLSMAHAGYKCVVQFVSLLLGNIEQIHGTYYVPLKDANNFPIAPGAD 355
Query: 278 SPLYKSEGIEFFASPVTLGPEGVEKIHG--IGALSEKE-EEMLAKCKETLKKNIEKGQKF 334
L +G ++FA P+T+ +GV + + +++ E +ML C LKKNI+KG +F
Sbjct: 356 QLLPLVDGADYFAIPLTITTKGVSYVDYDIVNRMNDMERNQMLPICVSQLKKNIDKGLEF 415
Query: 335 V 335
V
Sbjct: 416 V 416
>SPAC186.08c [C] KOG1495 Lactate dehydrogenase
Length = 330
Score = 75.5 bits (184), Expect = 1e-13
Identities = 79/335 (23%), Positives = 142/335 (41%), Gaps = 41/335 (12%)
Query: 12 STAFNPYKVTVLGAGGGIGQPLSLLLKLNHKVTDLRLYDL--KGAKGVAADLSHIPTNST 69
S++F K+ ++GAG +G + L L+ ++ + DL K A+G A DL+H
Sbjct: 15 SSSFKSIKIVIVGAGN-VGSTTAFTLLLSGLAAEIVIIDLNKKKAEGEAMDLNHA----- 68
Query: 70 VTGFTPESKESQAELA--AALKDTEVVLIPAGVPRKPGMTRDDLFSINAGIVRDLXXXXX 127
P S E++ L KD V+I AG +KPG TR DL N I +++
Sbjct: 69 ----APLSHETRVYLGDYKDCKDATAVVITAGKNQKPGETRMDLLKANISIFKEILREVT 124
Query: 128 XXXXXXXXLVISNPVNSTVPIVAEVLKQNGVYNPKKLFGVTTLDVIRSSRFISEIRNTDP 187
LV +NPV+ + LK G + + T +D R I ++ DP
Sbjct: 125 KYTKDAILLVATNPVD---VLTYATLKLTGFPAERVIGSGTIIDTARFQYLIGKLYGLDP 181
Query: 188 TTERVTVVGGH-------------SGITILPLISQTKHKSMIQGETLDKLVHRIQFGGDE 234
+ ++G H +G+++ +++ K + L++ + +
Sbjct: 182 QSVNADIIGEHGDSELAVWSHASIAGLSLADFCEESETK--YDEQALNECFKETKNAAYD 239
Query: 235 VVQAKNGAGSATLSMAEAGARFANSVLAGFEGERDVVESTFVDSPLYKSEGIEFFASPVT 294
++Q K GS +A R +++ E ++ + +DS Y + G F+ P
Sbjct: 240 IIQRK---GSTEYGVAAGLVRILAAII---RDENALLTVSGLDS--YSNIGDVCFSMPRK 291
Query: 295 LGPEGVEKIHGIGALSEKEEEMLAKCKETLKKNIE 329
L +G +I LS+ E+ L + +++K IE
Sbjct: 292 LNKDGAHRIIN-AKLSKDEDAKLVESVKSIKHAIE 325
>At4g17260 [C] KOG1495 Lactate dehydrogenase
Length = 353
Score = 58.2 bits (139), Expect = 2e-08
Identities = 68/327 (20%), Positives = 133/327 (39%), Gaps = 30/327 (9%)
Query: 19 KVTVLGAGGGIGQPLSLLLKLNHKVTDLRLYDLKGAK--GVAADLSHIPTNSTVTGFTPE 76
KV+V+G G +G ++ + ++ L D K K G DL H F P
Sbjct: 42 KVSVVGVGN-VGMAIAQTILTQDLADEIALVDAKPDKLRGEMLDLQH------AAAFLPR 94
Query: 77 SKESQAELAAALKDTEVVLIPAGVPRKPGMTRDDLFSINAGIVRDLXXXXXXXXXXXXXL 136
+K + + +++ ++ AG + PG +R +L N + R + +
Sbjct: 95 TKITASVDYEVTAGSDLCIVTAGARQNPGESRLNLLQRNVALFRHIIPPLAKASPDSILI 154
Query: 137 VISNPVNSTVPIVAEVLKQNGVYNPKKLFGVTTLDVIRSSRFISEIRNTDPTTERVTVVG 196
++SNPV+ + K +G + L T LD R I++ + + + +VG
Sbjct: 155 IVSNPVDVLTYV---AWKLSGFPVNRVLGSGTNLDSSRFRFLIADHLDVNAQDVQAFIVG 211
Query: 197 GHSGITI----------LPLIS-QTKHKSMIQGETLDKLVHRIQFGGDEVVQAKNGAGSA 245
H ++ +P++S K++ + +TL+ + + EV+ K G
Sbjct: 212 EHGDSSVALWSSISVGGIPVLSFLEKNQIAYEKQTLEDIHQAVVGSAYEVIGLK---GYT 268
Query: 246 TLSMAEAGARFANSVLAGFEGERDVVESTFVDSPLYKSEGIEFFAS-PVTLGPEGVEKIH 304
+ ++ + A A ++L +R + T + Y +G + F S P LG GV +
Sbjct: 269 SWAIGYSVANLARTIL---RDQRKIHPVTVLARGFYGVDGGDVFLSLPALLGRNGVVAVT 325
Query: 305 GIGALSEKEEEMLAKCKETLKKNIEKG 331
+ E+ E++ K L+ + G
Sbjct: 326 NVHMTDEEAEKLQKSAKTILEMQSQLG 352
>Hs4504973 [C] KOG1495 Lactate dehydrogenase
Length = 332
Score = 55.8 bits (133), Expect = 9e-08
Identities = 82/327 (25%), Positives = 138/327 (42%), Gaps = 35/327 (10%)
Query: 19 KVTVLGAGGGIGQPLSLLLKLNHKVTDLRLYD--LKGAKGVAADLSHIPTNSTVTGFTPE 76
K+T++G G +G ++ + L +L L D L KG DL H F
Sbjct: 22 KITIVGTGA-VGMACAISILLKDLADELALVDVALDKLKGEMMDLQHGSL------FFST 74
Query: 77 SKESQAELAAALKDTEVVLIPAGVPRKPGMTRDDLFSINAGIVRDLXXXXXXXXXXXXXL 136
SK + + + ++ +V++ AG ++ G TR L N I++ + L
Sbjct: 75 SKITSGKDYSVSANSRIVIVTAGARQQEGETRLALVQRNVAIMKSIIPAIVHYSPDCKIL 134
Query: 137 VISNPVNSTVPIVAEVLKQNGVYNPKKLFGVTTLDVIRSSRFISEIRNTDPTTERVTVVG 196
V+SNPV+ IV ++ +G+ + + LD R I E PT+ ++G
Sbjct: 135 VVSNPVDILTYIVWKI---SGLPVTRVIGSGCNLDSARFRYLIGEKLGVHPTSCHGWIIG 191
Query: 197 GHSGITILPLISQTKHKSMIQGETLD------------KLVHR-IQFGGDEVVQAKNGAG 243
H G + +PL S + + + +TLD K +H+ + E+++ K G
Sbjct: 192 EH-GDSSVPLWSGV-NVAGVALKTLDPKLGTDSDKEHWKNIHKQVIQSAYEIIKLK---G 246
Query: 244 SATLSMAEAGARFANSVLAGFEGERDVVESTFVDSPLYKSEGIEFFASPVTLGPEGVEKI 303
+ ++ + S+L V ST V LY + F + P LG GV +
Sbjct: 247 YTSWAIGLSVMDLVGSILKNLRRVHPV--STMVKG-LYGIKEELFLSIPCVLGRNGVSDV 303
Query: 304 HGIGALSEKEEEMLAKCKETLKKNIEK 330
I L+ +EE + K ETL NI+K
Sbjct: 304 VKIN-LNSEEEALFKKSAETL-WNIQK 328
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.314 0.134 0.367
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,249,909
Number of Sequences: 60738
Number of extensions: 732787
Number of successful extensions: 1638
Number of sequences better than 1.0e-05: 18
Number of HSP's better than 0.0 without gapping: 15
Number of HSP's successfully gapped in prelim test: 3
Number of HSP's that attempted gapping in prelim test: 1582
Number of HSP's gapped (non-prelim): 18
length of query: 338
length of database: 30,389,216
effective HSP length: 107
effective length of query: 231
effective length of database: 23,890,250
effective search space: 5518647750
effective search space used: 5518647750
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)