ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactVI7190 good I KOG1933 Lipid transport and metabolism Cholesterol transport protein (Niemann-Pick C disease protein)
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactVI7190 2508559 2505029 -1177
(1177 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YPL006w [I] KOG1933 Cholesterol transport protein (Niemann-Pick ... 1422 0.0
Hs4557803 [I] KOG1933 Cholesterol transport protein (Niemann-Pic... 503 e-142
At1g42470 [I] KOG1933 Cholesterol transport protein (Niemann-Pic... 472 e-132
7297621 [I] KOG1933 Cholesterol transport protein (Niemann-Pick ... 446 e-124
Hs7019469 [I] KOG1933 Cholesterol transport protein (Niemann-Pic... 416 e-115
7295561 [I] KOG1933 Cholesterol transport protein (Niemann-Pick ... 404 e-112
CE24891 [I] KOG1933 Cholesterol transport protein (Niemann-Pick ... 274 5e-73
At4g38350 [I] KOG1933 Cholesterol transport protein (Niemann-Pic... 273 2e-72
CE29251 [I] KOG1933 Cholesterol transport protein (Niemann-Pick ... 231 7e-60
CE08532 [R] KOG1934 Predicted membrane protein (patched superfam... 121 7e-27
CE12664 [R] KOG1934 Predicted membrane protein (patched superfam... 103 2e-21
7302178 [R] KOG1934 Predicted membrane protein (patched superfam... 101 6e-21
CE06861 [R] KOG1934 Predicted membrane protein (patched superfam... 97 2e-19
CE19144 [R] KOG1934 Predicted membrane protein (patched superfam... 92 6e-18
CE05777 [R] KOG1934 Predicted membrane protein (patched superfam... 92 6e-18
CE29399 [R] KOG1934 Predicted membrane protein (patched superfam... 91 8e-18
CE23110 [R] KOG1934 Predicted membrane protein (patched superfam... 89 3e-17
Hs4506247_1 [T] KOG1935 Membrane protein Patched/PTCH 89 4e-17
Hs4506245 [T] KOG1935 Membrane protein Patched/PTCH 86 4e-16
CE01865 [R] KOG1934 Predicted membrane protein (patched superfam... 85 6e-16
7304020 [T] KOG1935 Membrane protein Patched/PTCH 84 1e-15
CE01720 [T] KOG1935 Membrane protein Patched/PTCH 83 3e-15
CE21403 [R] KOG1934 Predicted membrane protein (patched superfam... 77 1e-13
CE21608 [R] KOG1934 Predicted membrane protein (patched superfam... 76 4e-13
CE01915 [T] KOG1935 Membrane protein Patched/PTCH 73 2e-12
Hs17462432 [I] KOG1933 Cholesterol transport protein (Niemann-Pi... 71 9e-12
CE13900 [R] KOG1934 Predicted membrane protein (patched superfam... 67 1e-10
CE29096 [T] KOG1935 Membrane protein Patched/PTCH 67 2e-10
CE25194 [T] KOG1935 Membrane protein Patched/PTCH 67 2e-10
CE24422 [R] KOG1934 Predicted membrane protein (patched superfam... 64 1e-09
CE29236 [R] KOG1934 Predicted membrane protein (patched superfam... 63 3e-09
CE02557 [R] KOG1934 Predicted membrane protein (patched superfam... 61 1e-08
CE01000 [R] KOG1934 Predicted membrane protein (patched superfam... 59 6e-08
Hs20555011 [R] KOG1934 Predicted membrane protein (patched super... 55 8e-07
CE01601 [R] KOG1934 Predicted membrane protein (patched superfam... 55 8e-07
CE17902 [R] KOG1934 Predicted membrane protein (patched superfam... 54 1e-06
CE15305 [R] KOG1934 Predicted membrane protein (patched superfam... 52 4e-06
>YPL006w [I] KOG1933 Cholesterol transport protein (Niemann-Pick C disease
protein)
Length = 1170
Score = 1422 bits (3682), Expect = 0.0
Identities = 674/1165 (57%), Positives = 880/1165 (74%), Gaps = 11/1165 (0%)
Query: 5 WIYVAVALLIHTCYAQESCAMYGNCGKKGVFGASLPCPVDADFEPPVIDQGDVQFLVDIC 64
WI V L+ +CAMYGNCGKK VFG LPCPV FEPPV+ + LV++C
Sbjct: 5 WIIALVGQLMRLVQGTATCAMYGNCGKKSVFGNELPCPVPRSFEPPVLSDETSKLLVEVC 64
Query: 65 GEEWRDNERLCCTREQMEALKENLNKAESIIASCPACKKNFNTIFCHFTCSPNQRQFIDI 124
GEEW++ CCT++Q+ AL++NL KA+ +I+SCPAC KNFN +FCHFTC+ +Q +F++I
Sbjct: 65 GEEWKEVRYACCTKDQVVALRDNLQKAQPLISSCPACLKNFNNLFCHFTCAADQGRFVNI 124
Query: 125 ISTDESSDGREIVSELNFFLNSSWASSFYDSCKNVKFSATNGYAMDLIGGGASDYSEFMK 184
++S + ++IV+EL+ F+NSSWAS FYDSCKN+KFSATNGYAMDLIGGGA +YS+F+K
Sbjct: 125 TKVEKSKEDKDIVAELDVFMNSSWASEFYDSCKNIKFSATNGYAMDLIGGGAKNYSQFLK 184
Query: 185 FLGDKKPALGGSPFQINYEYETSSDE--YSLFDENVFACSDPKYKCACADCSNSCPTLAP 242
FLGD KP LGGSPFQINY+Y+ +++E + F++ V+AC D +YKCAC+DC SCP L P
Sbjct: 185 FLGDAKPMLGGSPFQINYKYDLANEEKEWQEFNDEVYACDDAQYKCACSDCQESCPHLKP 244
Query: 243 IKKGRCMVAGIPCTSXXXXXXXXXXXXXIGGWHIIIFRRRKIKSTNIVEGSEPLLDNGNA 302
+K G C V +PC S W+ + R+ K+ ++ + + ++G+
Sbjct: 245 LKDGVCKVGPLPCFSLSVLIFYTICALFAFMWYYLCKRK---KNGAMIVDDDIVPESGSL 301
Query: 303 ANSDIDDGLFVEYATERNAMNDKISDVLSNTVAACIKNPITVLSYSXXXXXXXXXXXXVF 362
S+ + +F + E N N K++++ + ++NP +L + +
Sbjct: 302 DESETN--VFESFNNETNFFNGKLANLFTKVGQFSVENPYKILITTVFSIFVFSFIIFQY 359
Query: 363 GDLETDPVNLWVNPSSPKFKEKTHFDANFGPFYRTEQVFIVNDTGPVLSYENLKWWFETE 422
LETDP+NLWV+ +S KFKEK +FD NFGPFYRTEQ+F+VN+TGPVLSYE L WWF+ E
Sbjct: 360 ATLETDPINLWVSKNSEKFKEKEYFDDNFGPFYRTEQIFVVNETGPVLSYETLHWWFDVE 419
Query: 423 NLITENLLSTENISYQDLCFRPTEDSTCVIESVTQYFQGILPDESSWKQQLESCTDSPVN 482
N ITE L S+ENI YQDLCFRPTEDSTCVIES TQYFQG LP++ SWK++L+ C PVN
Sbjct: 420 NFITEELQSSENIGYQDLCFRPTEDSTCVIESFTQYFQGALPNKDSWKRELQECGKFPVN 479
Query: 483 CLPSFQQPLKTNVLFSDENVFESNAFVVTLLLSNHTESAKLWEEKLEQYLLSLSIPDGLR 542
CLP+FQQPLKTN+LFSD+++ ++AFVVTLLL+NHT+SA WEE+LE+YLL L +P+GLR
Sbjct: 480 CLPTFQQPLKTNLLFSDDDILNAHAFVVTLLLTNHTQSANRWEERLEEYLLDLKVPEGLR 539
Query: 543 ISFNTEMSLEKELNSSSDIIVVSASYLIMFFYASWALKRRTGGSRYLLGCAGVLIVFSSV 602
ISFNTE+SLEKELN+++DI V+ SYL+MF YA+WAL+R+ G +R LLG +G+LIV +S+
Sbjct: 540 ISFNTEISLEKELNNNNDISTVAISYLMMFLYATWALRRKDGKTRLLLGISGLLIVLASI 599
Query: 603 IASSGLLSIFGIKSTLILAEVIPFLILAIGIDNIFLITHEFDRVNSHYSSSTIQEKIVLS 662
+ ++G L++FG+KSTLI+AEVIPFLILAIGIDNIFLITHE+DR +I +KI+ +
Sbjct: 600 VCAAGFLTLFGLKSTLIIAEVIPFLILAIGIDNIFLITHEYDRNCEQKPEYSIDQKIISA 659
Query: 663 IGKISPSILFSFLCQGGCFLLATMVEMPAVRNFAICAAVALCFNVVLQLTSYVCILHFYE 722
IG++SPSIL S LCQ GCFL+A V MPAV NFAI + V++ FN VLQLT+YV IL YE
Sbjct: 660 IGRMSPSILMSLLCQTGCFLIAAFVTMPAVHNFAIYSTVSVIFNGVLQLTAYVSILSLYE 719
Query: 723 KYYDAANVEELTDDNE-EEGVLNRTFLSLLDKKRKVLGVFFSWFIISLVFLPSIKFGLDQ 781
K +N +++T + E +E L + +L +KR ++ +F +WF SLVFLP I+FGLDQ
Sbjct: 720 K---RSNYKQITGNEETKESFLKTFYFKMLTQKRLIIIIFSAWFFTSLVFLPEIQFGLDQ 776
Query: 782 TMAVPQNSYLVNYFQDVYEYLNVGPPVYFVVKNLDLRIKSAQKKICGKFTECDDYSLGNV 841
T+AVPQ+SYLV+YF+DVY +LNVGPPVY VVKNLDL + Q+KICGKFT C+ SL NV
Sbjct: 777 TLAVPQDSYLVDYFKDVYSFLNVGPPVYMVVKNLDLTKRQNQQKICGKFTTCERDSLANV 836
Query: 842 LELERLRSSIVEPLANWYDDYMMFLNPELDQCCRLKKGSEEICPPHFPPRRCETCYKDGE 901
LE ER RS+I EPLANW DDY MFLNP+ DQCCRLKKG++E+CPP FP RRCETC++ G
Sbjct: 837 LEQERHRSTITEPLANWLDDYFMFLNPQNDQCCRLKKGTDEVCPPSFPSRRCETCFQQGS 896
Query: 902 WDYDMSGFPEGDEFMKYFDIWINAPSDPCPLGGKSPYSSAIVYNDSNIITSTFRTGHSPL 961
W+Y+MSGFPEG +FM+Y IWINAPSDPCPLGG++PYS+A+VYN++++ S FRT H PL
Sbjct: 897 WNYNMSGFPEGKDFMEYLSIWINAPSDPCPLGGRAPYSTALVYNETSVSASVFRTAHHPL 956
Query: 962 RSQEDYINAYKDAQRIVDELNDLDVYAYSPFYIFFVQYSTIVSLTAKLITASILLIFFVS 1021
RSQ+D+I AY D RI +LD++AYSPFYIFFVQY T+ LT KLI ++I+LIFF+S
Sbjct: 957 RSQKDFIQAYSDGVRISSSFPELDMFAYSPFYIFFVQYQTLGPLTLKLIGSAIILIFFIS 1016
Query: 1022 WLLLGSAMTSLILSGIVTMIIVDILAMMYFFGIRLNAVSLVNLLICVGLAVEFCIHITRA 1081
+ L + +S +L+ +VTMIIVDI A+M GI LNAVSLVNL+ICVGL VEFC+HI R+
Sbjct: 1017 SVFLQNIRSSFLLALVVTMIIVDIGALMALLGISLNAVSLVNLIICVGLGVEFCVHIVRS 1076
Query: 1082 FTIVPVGVKKDRNSRVIYAMTTIGGSVLKGITMTKIIGISVLALTQSKIFQVFYFRMWAS 1141
FT+VP KKD NSRV+Y++ TIG SV+KGIT+TK IG+ VLA QSKIF VFYFRMW +
Sbjct: 1077 FTVVPSETKKDANSRVLYSLNTIGESVIKGITLTKFIGVCVLAFAQSKIFDVFYFRMWFT 1136
Query: 1142 LIFVASLHALIFLPVLLSMIGGKCF 1166
LI VA+LHAL+FLP LLS+ GG+ +
Sbjct: 1137 LIIVAALHALLFLPALLSLFGGESY 1161
>Hs4557803 [I] KOG1933 Cholesterol transport protein (Niemann-Pick C disease
protein)
Length = 1278
Score = 503 bits (1294), Expect = e-142
Identities = 379/1266 (29%), Positives = 621/1266 (48%), Gaps = 139/1266 (10%)
Query: 12 LLIHTCYAQ---ESCAMYGNCGKKGVFGASLPCPVDADFEPPVIDQGDVQFLVDICGEEW 68
LL+ C AQ +SC YG CG + + P + + + ++C +
Sbjct: 11 LLLLLCPAQVFSQSCVWYGECG---IAYGDKRYNCEYSGPPKPLPKDGYDLVQELCPGFF 67
Query: 69 RDNERLCCTREQMEALKENLNKAESIIASCPACKKNFNTIFCHFTCSPNQRQFIDIISTD 128
N LCC Q++ LK+NL ++ CP+C N +FC TCSP Q QF+++ +T+
Sbjct: 68 FGNVSLCCDVRQLQTLKDNLQLPLQFLSRCPSCFYNLLNLFCELTCSPRQSQFLNVTATE 127
Query: 129 ESSDG-----REIVSELNFFLNSSWASSFYDSCKNVKFSATNGYAMDLIGGGASDY---S 180
+ D + V EL +++ S+A++ Y++C++V+ ++N A+ L+ G +D +
Sbjct: 128 DYVDPVTNQTKTNVKELQYYVGQSFANAMYNACRDVEAPSSNDKALGLLCGKDADACNAT 187
Query: 181 EFMKFLGDKKPALGGSPFQIN--------YEYETSSDEYSLFDENVFACSDPKYKCACAD 232
+++++ +K G +PF I + E ++ DE+V + P C+C D
Sbjct: 188 NWIEYMFNKDN--GQAPFTITPVFSDFPVHGMEPMNNATKGCDESVDEVTAP---CSCQD 242
Query: 233 CSNSC--PTLAPIKKGRCMVAGIPCTSXXXXXXXXXXXXXIGGWHIIIFRRRKIKSTNIV 290
CS C P + G+ G ++ RK V
Sbjct: 243 CSIVCGPKPQPPPPPAPWTILGLDAMYVIMWITYMAFLLVFFGAFFAVWCYRK---RYFV 299
Query: 291 EGSEPLLDNGNAANSDIDDGLFVEYATERNAMNDKISDVLSNTVAACIKNPITVLSYSXX 350
P+ N + + D G A + + + + C++NP V+ +S
Sbjct: 300 SEYTPIDSNIAFSVNASDKGEASCCDPVSAAFEGCLRRLFTRWGSFCVRNPGCVIFFSLV 359
Query: 351 XXXXXXXXXXVFGDLETDPVNLWVNPSSPKFKEKTHFDANFGPFYRTEQVFI---VNDT- 406
VF + T+PV+LW PSS EK +FD +FGPF+RTEQ+ I + D
Sbjct: 360 FITACSSGL-VFVRVTTNPVDLWSAPSSQARLEKEYFDQHFGPFFRTEQLIIRAPLTDKH 418
Query: 407 -------------GPVLSYENLKWWFETENLITENLLST---ENISYQDLCFRPTE--DS 448
GP L + L + + I EN+ ++ E ++ QD+C P ++
Sbjct: 419 IYQPYPSGADVPFGPPLDIQILHQVLDLQIAI-ENITASYDNETVTLQDICLAPLSPYNT 477
Query: 449 TCVIESVTQYFQG---ILPDE--------SSWKQQLESCTDSPVN----------CLPSF 487
C I SV YFQ +L + + + C +P + CL +F
Sbjct: 478 NCTILSVLNYFQNSHSVLDHKKGDDFFVYADYHTHFLYCVRAPASLNDTSLLHDPCLGTF 537
Query: 488 QQPLKTNVL---FSDENVFESNAFVVTLLLSNH------TESAKLWEEKLEQYLLSLSIP 538
P+ ++ + D+N + A V+T ++N+ + A+ WE++ ++ + P
Sbjct: 538 GGPVFPWLVLGGYDDQNYNNATALVITFPVNNYYNDTEKLQRAQAWEKEFINFVKNYKNP 597
Query: 539 DGLRISFNTEMSLEKELN--SSSDIIVVSASYLIMFFYASWAL------KRRTGGSRYLL 590
+ L ISF E S+E ELN S SD+ V SY IMF Y S AL +R S+ L
Sbjct: 598 N-LTISFTAERSIEDELNRESDSDVFTVVISYAIMFLYISLALGHIKSCRRLLVDSKVSL 656
Query: 591 GCAGVLIVFSSVIASSGLLSIFGIKSTLILAEVIPFLILAIGIDNIFLITHEFDRVNSHY 650
G AG+LIV SSV S G+ S G+ TLI+ EVIPFL+LA+G+DNIF++ + R +
Sbjct: 657 GIAGILIVLSSVACSLGVFSYIGLPLTLIVIEVIPFLVLAVGVDNIFILVQAYQR-DERL 715
Query: 651 SSSTIQEKIVLSIGKISPSILFSFLCQGGCFLLATMVEMPAVRNFAICAAVALCFNVVLQ 710
T+ +++ +G+++PS+ S + F L + MPAV F++ A +A+ + +LQ
Sbjct: 716 QGETLDQQLGRVLGEVAPSMFLSSFSETVAFFLGALSVMPAVHTFSLFAGLAVFIDFLLQ 775
Query: 711 LTSYVCILHFYEKYYD---------AANVEELTDDNEEEGVLNRTF------LSLLDKKR 755
+T +V +L K + E+ T E L R F L L D R
Sbjct: 776 ITCFVSLLGLDIKRQEKNRLDIFCCVRGAEDGTSVQASESCLFRFFKNSYSPLLLKDWMR 835
Query: 756 K-VLGVFFSWFIISLVFLPSIKFGLDQTMAVPQNSYLVNYFQDVYEYLNVGPPVYFVVKN 814
V+ +F S+ L + GLDQ++++P +SY+V+YF+ + +YL+ GPPVYFV++
Sbjct: 836 PIVIAIFVGVLSFSIAVLNKVDIGLDQSLSMPDDSYMVDYFKSISQYLHAGPPVYFVLEE 895
Query: 815 -LDLRIKSAQKKICGKFTECDDYSLG----NVLELERLRSSIVEPLANWYDDYMMFLNPE 869
D Q +CG C++ SL N +L+ P ++W DDY ++ P+
Sbjct: 896 GHDYTSSKGQNMVCGGMG-CNNDSLVQQIFNAAQLDNYTRIGFAP-SSWIDDYFDWVKPQ 953
Query: 870 LDQCCRLKKGSEEICPPHFPPRRCETCYKDGEWDYDMSGFPEGDEFMKYFDIWINA-PSD 928
CCR+ +++ C C C + P+G +FM++ ++++ P+
Sbjct: 954 -SSCCRVDNITDQFCNASVVDPACVRCRP---LTPEGKQRPQGGDFMRFLPMFLSDNPNP 1009
Query: 929 PCPLGGKSPYSSAI---VYNDSNIITSTFRTGHSPLRSQEDYINAYKDAQRIVDELNDL- 984
C GG + YSSA+ + + + + + F T H+ L++ D+I+A K A+ I + +
Sbjct: 1010 KCGKGGHAAYSSAVNILLGHGTRVGATYFMTYHTVLQTSADFIDALKKARLIASNVTETM 1069
Query: 985 -------DVYAYSPFYIFFVQYSTIVSLTAKLITASILLIFFVSWLLLGSAMTS-LILSG 1036
V+ YS FY+F+ QY TI+ T + S+ IF V+ +LLG + S +I+
Sbjct: 1070 GINGSAYRVFPYSVFYVFYEQYLTIIDDTIFNLGVSLGAIFLVTMVLLGCELWSAVIMCA 1129
Query: 1037 IVTMIIVDILAMMYFFGIRLNAVSLVNLLICVGLAVEFCIHITRAFTIVPVGVKKDRNSR 1096
+ M++V++ +M+ +GI LNAVSLVNL++ G++VEFC HITRAFT V +K R R
Sbjct: 1130 TIAMVLVNMFGVMWLWGISLNAVSLVNLVMSCGISVEFCSHITRAFT---VSMKGSRVER 1186
Query: 1097 VIYAMTTIGGSVLKGITMTKIIGISVLALTQSKIFQVFYFRMWASLIFVASLHALIFLPV 1156
A+ +G SV GIT+TK GI VLA +S+IFQ+FYFRM+ +++ + + H LIFLPV
Sbjct: 1187 AEEALAHMGSSVFSGITLTKFGGIVVLAFAKSQIFQIFYFRMYLAMVLLGATHGLIFLPV 1246
Query: 1157 LLSMIG 1162
LLS IG
Sbjct: 1247 LLSYIG 1252
>At1g42470 [I] KOG1933 Cholesterol transport protein (Niemann-Pick C disease
protein)
Length = 1248
Score = 472 bits (1215), Expect = e-132
Identities = 345/1159 (29%), Positives = 560/1159 (47%), Gaps = 134/1159 (11%)
Query: 23 CAMYGNCGKKGVFGASLPCPVDA-DFEPPVIDQGDVQFLVDICGEEWRDNERLCCTREQM 81
CAMY CG + G L CP + +P + +Q L +CCT Q
Sbjct: 19 CAMYDICGARSD-GKVLNCPFNIPSVKPDDLLSSKIQSLCPTI------TGNVCCTETQF 71
Query: 82 EALKENLNKAESIIASCPACKKNFNTIFCHFTCSPNQRQFIDIISTDESSDGREIVSELN 141
+ L+ + +A I CPAC +NF +FC TCSP+Q FI++ ST + + V +
Sbjct: 72 DTLRSQVQQAIPFIVGCPACLRNFLNLFCELTCSPDQSLFINVTSTTKVKNN-STVDGIQ 130
Query: 142 FFLNSSWASSFYDSCKNVKFSATNGYAMDLIGGGASDYSEFMKFLGDKKPA-LGGSPFQI 200
+++ + + Y+SCKNVKF ++N A+D +G GA ++ E+ F+G K L GSP+ I
Sbjct: 131 YYITDDFGAGMYESCKNVKFGSSNSRALDFLGAGAKNFKEWFTFIGQKAGVNLPGSPYGI 190
Query: 201 NY-EYETSSDEYSLFDENVFACSDPKYKCACADCSNS--CPTLAPI---KKGRCMVA--- 251
+ S + ++++C D C+C DC ++ C + A + KK C +
Sbjct: 191 AFLPTPPVSSGMRPMNVSIYSCGDESLGCSCGDCPSAATCSSKAEVPTQKKHSCSIKIGS 250
Query: 252 -GIPCTSXXXXXXXXXXXXXIGGWHIIIFRRRKIKSTNIVEGSEPLLDNG--NAANSDID 308
+ C G ++ R K K++ + SE + N D
Sbjct: 251 LEVKCVDFILAILYIVLVSLFLGGGLLHPVRGKKKTSQMGTLSEASGERNSVNQQKPDTI 310
Query: 309 DGLFVEYATERN-----AMNDKISDVLSNTVAACIKNPITVLSYSXXXXXXXXXXXXVFG 363
++ +RN + +++ ++P VL S F
Sbjct: 311 QSQMLQNTPQRNWGQLSTVQGHLANFYGKYGIWVARHPTLVLCLSVSVVLLLCVGLIRF- 369
Query: 364 DLETDPVNLWVNPSSPKFKEKTHFDANFGPFYRTEQVFIV------NDTGP-VLSYENLK 416
+ET P LWV S +EK FD + PFYR EQ+ I ++ P +L+ +N+K
Sbjct: 370 KVETRPDKLWVGSGSRAAEEKQFFDTHLAPFYRIEQLIIATVQTSSHEKAPEILTDDNIK 429
Query: 417 WWFETENLITENLLSTEN---ISYQDLCFRPTEDSTCVIESVTQYFQGILPDESSWKQQL 473
F+ + + + L + + +S D+C +P + C +SV Q+F
Sbjct: 430 LLFDIQKKV-DGLRANHSGSMVSLTDICMKPLGED-CATQSVLQHFT------------- 474
Query: 474 ESCTDSPVNCLPSFQQPLKTNVL---FSDENVFESNAFVVTLLLSNH-------TESAKL 523
S +CL +F+ PL FS + E++AF+VT + N TE A
Sbjct: 475 -----STESCLSAFKGPLDPTTALGGFSGNSFSEASAFLVTYPVDNFVDNKGNKTEKAVA 529
Query: 524 WEEKLEQY----LLSLSIPDGLRISFNTEMSLEKELN--SSSDIIVVSASYLIMFFYASW 577
WE+ Q LL + L +SF++E S+E+EL S++D+I ++ SYL+MF Y S
Sbjct: 530 WEKAFIQLAKDELLPMVQAKNLTLSFSSESSIEEELKRESTADVITIAISYLVMFAYISL 589
Query: 578 AL------KRRTGGSRYLLGCAGVLIVFSSVIASSGLLSIFGIKSTLILAEVIPFLILAI 631
L K S+ LLG +GVL+V SV+ S G S G+KSTLI+ EVIPFL+LA+
Sbjct: 590 TLGDSPRLKSFYITSKVLLGLSGVLLVMLSVLGSVGFFSAVGMKSTLIIMEVIPFLVLAV 649
Query: 632 GIDNIFLITHEFDRVNSHYSSSTIQEKIVLSIGKISPSILFSFLCQGGCFLLATMVEMPA 691
G+DN+ ++ H R ++ +I ++ ++ PSI + L + F + ++MPA
Sbjct: 650 GVDNMCILVHAVKRQEQELP---LERRISNALMEVGPSITLASLAEILAFAVGAFIKMPA 706
Query: 692 VRNFAICAAVALCFNVVLQLTSYVCILHFYEKYYDAANVE--------------ELTDDN 737
VR F++ AA+A+ + +LQ+T++V ++ F + + V+ E
Sbjct: 707 VRVFSMFAALAVLLDFLLQITAFVALIVFDFRRTEDKRVDCFPCIKTSKSSISAEKGVGQ 766
Query: 738 EEEGVLNRTF-------LSLLDKKRKVLGVFFSWFIISLVFLPSIKFGLDQTMAVPQNSY 790
+ G+L R LS K V+ FF + + I+ GL+Q + +PQ+SY
Sbjct: 767 RKAGLLTRYMKEVHAPVLSHWIVKIVVIAFFFGLAMAGIALSTRIEPGLEQQIVLPQDSY 826
Query: 791 LVNYFQDVYEYLNVGPPVYFVVKNLDLRIKSAQKKICGKFTECDDYSLGNVLELERLR-- 848
L YF ++ YL +GPP+YFV+KN + +S +C+ SL N + L
Sbjct: 827 LQGYFNNISTYLRIGPPLYFVLKNYNYSSESRHTNQLCSINKCNPNSLLNEIARASLTPE 886
Query: 849 -SSIVEPLANWYDDYMMFLNPELDQCCRLKKGSEEICPPHFPP----------------R 891
S I +P A+W DD++++L+PE CCR K + CPP P +
Sbjct: 887 LSYIAKPAASWLDDFLVWLSPEAFGCCR-KFTNGTFCPPDDQPPCCPPGQTSCGLSEVCK 945
Query: 892 RCETCYKDGEWDYDMSGFPEGDEFMKYFDIWINA-PSDPCPLGGKSPYSSAIV---YNDS 947
C TC++ + D P +F + ++NA PS C GG YSS++ Y +
Sbjct: 946 DCTTCFRHADLSSDR---PSTTQFKEKLPWFLNALPSADCAKGGHGAYSSSVDLQGYANG 1002
Query: 948 NIITSTFRTGHSPLRSQEDYINAYKDAQRIVDELN---DLDVYAYSPFYIFFVQYSTIVS 1004
I S+FRT H+PL Q D++N+ + AQ +++ +++Y YS FY+FF QY I
Sbjct: 1003 IIQASSFRTYHTPLNKQVDFVNSMRAAQEFSAKVSRSLKMEIYPYSVFYMFFEQYLDIWK 1062
Query: 1005 LTAKLITASILLIFFVSWLLLGSAMTSLILSGIVTMIIVDILAMMYFFGIRLNAVSLVNL 1064
++ +I +F V ++ S +S I+ ++ MII+D+L +M F I+LNA+S+VNL
Sbjct: 1063 TALINLSIAIAAVFVVCLIITCSFWSSAIILLVIAMIIIDLLGVMAVFHIQLNALSVVNL 1122
Query: 1065 LICVGLAVEFCIHITRAFT 1083
++ VG+AVEFC+HIT AF+
Sbjct: 1123 IMSVGIAVEFCVHITHAFS 1141
>7297621 [I] KOG1933 Cholesterol transport protein (Niemann-Pick C disease
protein)
Length = 1157
Score = 446 bits (1146), Expect = e-124
Identities = 301/904 (33%), Positives = 480/904 (52%), Gaps = 118/904 (13%)
Query: 362 FGDLETDPVNLWVNPSSPKFKEKTHFDANFGPFYRTEQVFI--------VNDT------- 406
F ++ TDPV LW +P+S E+ FD F PFYR EQ+ I V++T
Sbjct: 243 FIEITTDPVKLWASPNSKSRLEREFFDTKFSPFYRLEQIIIKAVNLPQIVHNTSNGPYTF 302
Query: 407 GPVLSYENLKWWFETENLITENLLSTENISYQDLCFRPTED-------STCVIESVTQYF 459
GPV E L + + I E ++ +D+C+ P D S CV++S+ YF
Sbjct: 303 GPVFDREFLTKVLDLQEGIKE--INANGTQLKDICYAPLSDDGSEIDVSQCVVQSIWGYF 360
Query: 460 ---QGILPDES-------SWKQQLESCTDSPVNCLPSFQQPLKTNVLF----------SD 499
+ L D ++ L C +P CL + P+ + +
Sbjct: 361 GDDRERLDDHDEDNGFNVTYLDALYDCISNPYLCLAPYGGPVDPAIALGGFLPPGDQLTG 420
Query: 500 ENVFE-SNAFVVTLLLSNH-----TESAKLWEEKLEQYLLSLS---IPDGLRISFNTEMS 550
FE +NA ++T L+ NH E+A WE+K +++ + + + + I+F +E S
Sbjct: 421 STKFELANAIILTFLVKNHHNKTDLENALTWEKKFVEFMTNYTKNNMSQYMDIAFTSERS 480
Query: 551 LEKELN--SSSDIIVVSASYLIMFFYASWAL------KRRTGGSRYLLGCAGVLIVFSSV 602
+E ELN S SD++ + SYLIMF Y + +L KR S+ LG GV+IV +SV
Sbjct: 481 IEDELNRESQSDVLTILVSYLIMFMYIAISLGHVKEFKRVFIDSKITLGIGGVIIVLASV 540
Query: 603 IASSGLLSIFGIKSTLILAEVIPFLILAIGIDNIFLITHEFDRVNSHYSSSTIQEKIVLS 662
++S G+ G+ +TLI+ EVIPFL+LA+G+DNIF++ R + + T+++++
Sbjct: 541 VSSVGVFGYIGLPATLIIVEVIPFLVLAVGVDNIFILVQTHQR-DQRKPNETLEQQVGRI 599
Query: 663 IGKISPSILFSFLCQGGCFLLATMVEMPAVRNFAICAAVALCFNVVLQLTSYVCILHFYE 722
+GK+ PS+L + L + CF L + +MPAVR FA+ A VAL + +LQ+T +V +
Sbjct: 600 LGKVGPSMLLTSLSESFCFFLGGLSDMPAVRAFALYAGVALIIDFLLQITCFVSLFTLDT 659
Query: 723 KYYDAANVE--------ELTDDNEEEGVLNRTFLSL----LDKK---RKVLGVFFSWFII 767
K + ++ + EG+L + F S+ L KK V+ +FF+W
Sbjct: 660 KRREENRMDICCFIKGKKPDSITSNEGLLYKFFSSVYVPFLMKKIVRASVMVIFFAWLCF 719
Query: 768 SLVFLPSIKFGLDQTMAVPQNSYLVNYFQDVYEYLNVGPPVYFVVK-NLDLRIKSAQKKI 826
S+ P I GLDQ +A+PQ+S++++YFQ + E LN+GPPVYFV+K +L S Q +
Sbjct: 720 SIAIAPRIDIGLDQELAMPQDSFVLHYFQSLNENLNIGPPVYFVLKGDLAYTNSSDQNLV 779
Query: 827 C-GKFTECDDYSLGNVLELERLRSS---IVEPLANWYDDYMMFLNPELDQCCRLKKGSEE 882
C G++ C+D S+ + L S+ I P ++W DDY + CC+ +K S +
Sbjct: 780 CAGQY--CNDDSVLTQIYLASRHSNQTYIARPASSWIDDYFDWA-AAASSCCKYRKDSGD 836
Query: 883 ICPPHFPPRRCETCYKDGEWDYDMSGFPEGDEFMKYFDIWI-NAPSDPCPLGGKSPYSSA 941
CP + +C + + PE EF+KY ++ + P D C G + Y A
Sbjct: 837 FCP-----HQDTSCLRCNITKNSLLR-PEEKEFVKYLPFFLKDNPDDTCAKAGHAAYGGA 890
Query: 942 IVYNDS----NIITSTFRTGHSPLRSQEDYINAYKDAQRIVDELNDL------------- 984
+ Y++S NI S F H+ L+S DY A + A++I + +
Sbjct: 891 VRYSNSHERLNIEASYFMAYHTILKSSADYFLALESARKISANITQMLQGRLMSNGVPMA 950
Query: 985 -----DVYAYSPFYIFFVQYSTIVSLTAKLITASILLIFFVSWLLLG-SAMTSLILSGIV 1038
+V+ YS FY+F+ QY T+ S T + + S+L IF V+++L+G ++L++ +
Sbjct: 951 SALTVEVFPYSVFYVFYEQYLTMWSDTLQSMGISVLSIFVVTFVLMGFDVHSALVVVITI 1010
Query: 1039 TMIIVDILAMMYFFGIRLNAVSLVNLLICVGLAVEFCIHITRAFTIVPVGVKKDRNSRVI 1098
TMI+V++ +MY++ I LNAVSLVNL++ VG++VEFC H+ +F + DR +
Sbjct: 1011 TMIVVNLGGLMYYWNISLNAVSLVNLVMAVGISVEFCSHLVHSFATSKSVSQIDRAAD-- 1068
Query: 1099 YAMTTIGGSVLKGITMTKIIGISVLALTQSKIFQVFYFRMWASLIFVASLHALIFLPVLL 1158
+++ +G S+ GIT+TK GI VLA +S+IFQVFYFRM+ ++ + + H LIFLPVLL
Sbjct: 1069 -SLSKMGSSIFSGITLTKFAGILVLAFAKSQIFQVFYFRMYLGIVVIGAAHGLIFLPVLL 1127
Query: 1159 SMIG 1162
S IG
Sbjct: 1128 SYIG 1131
Score = 67.8 bits (164), Expect = 1e-10
Identities = 29/93 (31%), Positives = 53/93 (56%)
Query: 79 EQMEALKENLNKAESIIASCPACKKNFNTIFCHFTCSPNQRQFIDIISTDESSDGREIVS 138
+Q+E L +N+ A +I+ CP+C +N C FTCSP Q +F+ +++T ++ G E +S
Sbjct: 30 KQVELLNKNVELAGNILDRCPSCMENLVRHICQFTCSPKQAEFMHVVATQKNKKGDEYIS 89
Query: 139 ELNFFLNSSWASSFYDSCKNVKFSATNGYAMDL 171
++ +++ + + Y SC K A + DL
Sbjct: 90 SVDLHISTEYINKTYKSCSQSKLPACSCSDCDL 122
>Hs7019469 [I] KOG1933 Cholesterol transport protein (Niemann-Pick C disease
protein)
Length = 1359
Score = 416 bits (1069), Expect = e-115
Identities = 354/1316 (26%), Positives = 590/1316 (43%), Gaps = 187/1316 (14%)
Query: 1 MWYQWIYVAVALLIHTCYAQESCAMYGNCGKKGVFGASLPCPVDADF---EPPVIDQGDV 57
+W + +A + T + CA Y CGK SL + P GD
Sbjct: 11 LWALLLRLAQSEPYTTIHQPGYCAFYDECGKNPELSGSLMTLSNVSCLSNTPARKITGDH 70
Query: 58 QFLVD-ICGEEWRD-NERLCCTREQMEALKENLNKAESIIASCPACKKNFNTIFCHFTCS 115
L+ IC + N + CC+ +Q+ +L+ +L+ ++++ CPAC NF + CH TCS
Sbjct: 71 LILLQKICPRLYTGPNTQACCSAKQLVSLEASLSITKALLTRCPACSDNFVNLHCHNTCS 130
Query: 116 PNQRQFIDIISTDESSDGR-EIVSELNFFLNSSWASSFYDSCKNVKFSATNGYAMDLI-- 172
PNQ FI++ + G+ V F S+A YDSC V+ A A+ +
Sbjct: 131 PNQSLFINVTRVAQLGAGQLPAVVAYEAFYQHSFAEQSYDSCSRVRVPAAATLAVGTMCG 190
Query: 173 --GGGASDYSEFMKFLGDKKPALGGSPFQINYEY----ETSSDEYSLFDENVFACS---- 222
G + ++ F GD L +P I + + +E V C+
Sbjct: 191 VYGSALCNAQRWLNFQGDTGNGL--APLDITFHLLEPGQAVGSGIQPLNEGVARCNESQG 248
Query: 223 DPKYKCACADCSNSCPTLAPIKKGRCMVAGIPCTSXXXXXXXXXXXXXIGGWHIIIFRRR 282
D C+C DC+ A P + + G ++I
Sbjct: 249 DDVATCSCQDCA----------------ASCPAIARPQALDSTFYLGQMPGSLVLIIILC 292
Query: 283 KIKS--TNIVEGSE--PLLDNGNAANSDIDDGLFVEYATERNAMNDKISDVLSNTVAACI 338
+ + T ++ G P D + L + + + + + VA+
Sbjct: 293 SVFAVVTILLVGFRVAPARDKSKMVDPKKGTSLSDKLSFSTHTLLGQFFQGWGTWVASW- 351
Query: 339 KNPITVLSYSXXXXXXXXXXXXVFGDLETDPVNLWVNPSSPKFKEKTHFDANFGPFYRTE 398
P+T+L S VF +L TDPV LW P+S EK D +FGPF+RT
Sbjct: 352 --PLTILVLSVIPVVALAAGL-VFTELTTDPVELWSAPNSQARSEKAFHDQHFGPFFRTN 408
Query: 399 QVFIVNDTGPVLSYENLKWWFETENLITENLLSTE--------------------NISYQ 438
QV + Y++L + + I + L E NIS Q
Sbjct: 409 QVILTAPNRSSYRYDSLLLGPKNFSGILDLDLLLELLELQERLRHLQVWSPEAQRNISLQ 468
Query: 439 DLCFRPTE-DST----CVIESVTQYFQG-----------ILPDESS---WKQQLESCTDS 479
D+C+ P D+T C I S+ QYFQ L ++S WK C ++
Sbjct: 469 DICYAPLNPDNTSLYDCCINSLLQYFQNNRTLLLLTANQTLMGQTSQVDWKDHFLYCANA 528
Query: 480 PV----------NCLPSFQQPLKTNVL---FSDENVFESNAFVVTLLLSNHTES------ 520
P+ +C+ + P+ + + ++ E+ A ++T L+N+
Sbjct: 529 PLTFKDGTALALSCMADYGAPVFPFLAIGGYKGKDYSEAEALIMTFSLNNYPAGDPRLAQ 588
Query: 521 AKLWEEKL--EQYLLSLSIPDGLRISFNTEMSLEKELN--SSSDIIVVSASYLIMFFYAS 576
AKLWEE E + +++F E SLE E+N ++ D+ + + SY+++F Y S
Sbjct: 589 AKLWEEAFLEEMRAFQRRMAGMFQVTFMAERSLEDEINRTTAEDLPIFATSYIVIFLYIS 648
Query: 577 WALKRRTGGSRYL------LGCAGVLIVFSSVIASSGLLSIFGIKSTLILAEVIPFLILA 630
AL + SR + LG GV +V +V+A+ G S GI+S+L++ +V+PFL+L+
Sbjct: 649 LALGSYSSWSRVMVDSKATLGLGGVAVVLGAVMAAMGFFSYLGIRSSLVILQVVPFLVLS 708
Query: 631 IGIDNIFLITHEFDRVNSHYSSSTIQEKIVLSIGKISPSILFSFLCQGGCFLLATMVEMP 690
+G DNIF+ E+ R+ + I ++G+++PS+L L + CF L + MP
Sbjct: 709 VGADNIFIFVLEYQRLPRRPGEPR-EVHIGRALGRVAPSMLLCSLSEAICFFLGALTPMP 767
Query: 691 AVRNFAICAAVALCFNVVLQLTSYVCILHFYEKYYDAANVE--------ELTDDNEEEGV 742
AVR FA+ + +A+ + +LQ++++V +L K +A+ ++ EL + EG+
Sbjct: 768 AVRTFALTSGLAVILDFLLQMSAFVALLSLDSKRQEASRLDVCCCVKPQELPPPGQGEGL 827
Query: 743 L-------NRTFLSLLDKKRKVLGVFFSWFIISLVFLPSIKFGLDQTMAVPQNSYLVNYF 795
L FL + VL +F + F +SL + I GLDQ +A+P++SYL++YF
Sbjct: 828 LLGFFQKAYAPFLLHWITRGVVLLLFLALFGVSLYSMCHISVGLDQELALPKDSYLLDYF 887
Query: 796 QDVYEYLNVGPPVYFVVK-NLDLRIKSAQKKICGKFTECDDYSLGNVLELERL---RSSI 851
+ Y VG PVYFV + ++ IC C+++S ++ +S +
Sbjct: 888 LFLNRYFEVGAPVYFVTTLGYNFSSEAGMNAICSS-AGCNNFSFTQKIQYATEFPEQSYL 946
Query: 852 VEPLANWYDDYMMFLNPELDQCCRLK---KGSEEICPPHFPPRRC-ETCYKDGEWDYDMS 907
P ++W DD++ +L P CCRL ++ CP C + C S
Sbjct: 947 AIPASSWVDDFIDWLTPS--SCCRLYISGPNKDKFCPSTVNSLNCLKNCMSITMG----S 1000
Query: 908 GFPEGDEFMKYFDIWIN-APSDPCPLGGKSPYSSAI-VYNDSNII--------------- 950
P ++F KY ++N P+ CP GG + YS+++ + +D ++
Sbjct: 1001 VRPSVEQFHKYLPWFLNDRPNIKCPKGGLAAYSTSVNLTSDGQVLDTVAILSPRLEYSGT 1060
Query: 951 ------------TSTFRTGHSPLRSQEDYINAYKDAQRIVDELN-DL----------DVY 987
S F H PL++ +DY A + A+ + + DL +V+
Sbjct: 1061 ISAHCNLYLLDSASRFMAYHKPLKNSQDYTEALRAARELAANITADLRKVPGTDPAFEVF 1120
Query: 988 AYSPFYIFFVQYSTIVSLTAKLITASILLIFFVSWLLLGSAMTSLILSGI-VTMIIVDIL 1046
Y+ +F+ QY TI+ +++ ++ F VS LLLG + S +L+ + + MI+VD +
Sbjct: 1121 PYTITNVFYEQYLTILPEGLFMLSLCLVPTFAVSCLLLGLDLRSGLLNLLSIVMILVDTV 1180
Query: 1047 AMMYFFGIRLNAVSLVNLLICVGLAVEFCIHITRAFTIVPVGVKKDRNSRVIYAMTTIGG 1106
M +GI NAVSL+NL+ VG++VEF HITR+F I K R A ++G
Sbjct: 1181 GFMALWGISYNAVSLINLVSAVGMSVEFVSHITRSFAI---STKPTWLERAKEATISMGS 1237
Query: 1107 SVLKGITMTKIIGISVLALTQSKIFQVFYFRMWASLIFVASLHALIFLPVLLSMIG 1162
+V G+ MT + GI VL L ++++ Q+F+FR+ + + LH L+FLPV+LS +G
Sbjct: 1238 AVFAGVAMTNLPGILVLGLAKAQLIQIFFFRLNLLITLLGLLHGLVFLPVILSYVG 1293
>7295561 [I] KOG1933 Cholesterol transport protein (Niemann-Pick C disease
protein)
Length = 1223
Score = 404 bits (1038), Expect = e-112
Identities = 292/927 (31%), Positives = 469/927 (50%), Gaps = 116/927 (12%)
Query: 337 CIKNPITVLSYSXXXXXXXXXXXXVFGDLETDPVNLWVNPSSPKFKEKTHFDANFGPFYR 396
C K+P+ VL+ + + TDPV LW S EK +FD +FGPFYR
Sbjct: 290 CAKHPVIVLALCSWAIAGLSFGIR-YMTITTDPVELWAGEESQTRIEKDYFDQHFGPFYR 348
Query: 397 TEQVFI--VNDT-------------GPVLSYENLKWWFETENLITENLLSTENISYQDLC 441
T Q+F+ VN T GP Y LK FE ++ I + L +N +C
Sbjct: 349 TNQMFVKAVNQTYFTHETSNGVLNFGPAFEYNFLKEVFELQDSIMK-LGMADNEGLDKIC 407
Query: 442 FRPT----EDST---CVIESVTQYFQGILP-------DESSWK----QQLESCTDSPV-- 481
+ P E T C I+SV YFQ + D +++ QLE C P+
Sbjct: 408 YAPVLMAGETPTVDRCAIQSVYGYFQHDMDRFENSYVDSNNYTINYLNQLEDCLRVPMME 467
Query: 482 NCLPSFQQPLKTNVLFS---------DENVFESNAFVVTLLLSNHTESAKL-----WEEK 527
+C +F P++ + D + + V+T L N+ + +KL WE+
Sbjct: 468 DCFGTFGGPIEPGIAVGGMPKVAVGEDPDYMLATGLVLTFLGRNYNDESKLEPNMKWEKL 527
Query: 528 LEQYLLSLSIPDGLRISFNTEMSLEKELN--SSSDIIVVSASYLIMFFYASWALK--RRT 583
+L D L I++ E S++ + S ++ V SY++MF Y + AL R
Sbjct: 528 FVDFLRDYK-SDRLDIAYMAERSIQDAIVELSEGEVSTVVISYVVMFVYVAIALGHIRSC 586
Query: 584 GG----SRYLLGCAGVLIVFSSVIASSGLLSIFGIKSTLILAEVIPFLILAIGIDNIFLI 639
G SR +L G++IV +SV+ S G + +T++ EVIPFL+LA+G+DNIF++
Sbjct: 587 RGFLRESRIMLAIGGIVIVLASVVCSLGFWGYLDVTTTMLAIEVIPFLVLAVGVDNIFIM 646
Query: 640 THEFDRVNSHYSSSTIQEKIVLSIGKISPSILFSFLCQGGCFLLATMVEMPAVRNFAICA 699
H + R++ H T E I +IG++ PSIL + + CF + + +MPAV+ FA+ A
Sbjct: 647 VHTYQRLD-HSKFKTTHEAIGEAIGQVGPSILQTAGSEMACFAIGCISDMPAVKTFAMYA 705
Query: 700 AVALCFNVVLQLTSYVCILHFYEKYYDAANVEEL-----------------TDDNEEEGV 742
A+A+ + +LQ+T++V ++ EK Y ++ L D +E G+
Sbjct: 706 AIAILLDFLLQITAFVALMAIDEKRYLDGRLDMLCCVKSGGKKINDEDGDGVDRPKEVGL 765
Query: 743 LNRTFLS-----LLDK--KRKVLGVFFSWFIISLVFLPSIKFGLDQTMAVPQNSYLVNYF 795
L F + LL K K VL +F +SL+ PSI+ GLDQ M++P+NS++V YF
Sbjct: 766 LETLFKNFYSPFLLSKPVKVSVLLIFTVITCLSLMVTPSIEKGLDQEMSMPKNSHVVKYF 825
Query: 796 QDVYEYLNVGPPVYFVVK-NLDLRIKSAQKKICGKFTECDDYSLGNVLELERLR---SSI 851
+ + + L +G PVY+V+K L+ Q ICG EC++ SL L + +S+
Sbjct: 826 RYMVDLLAMGAPVYWVLKPGLNYSEPLQQNLICGG-VECNNNSLSVQLYTQAQYPEITSL 884
Query: 852 VEPLANWYDDYMMFLNPELDQCCRLKKGSEEICPPHFPPRRCETCYKDGEWDYDMSGF-P 910
P ++W DDY+ +L + CC+ + C + C C E + +G P
Sbjct: 885 ARPASSWLDDYIDWL--AISDCCKYNVTTGGFCSSNSKSEDCLPC----ERGFTENGLRP 938
Query: 911 EGDEFMKYFDIWI-NAPSDPCPLGGKSPYSSAIVYNDSNIITSTFRTGH-----SPLRSQ 964
+ + F KY ++ + P C G++ Y+ A++Y ++ ST + + + +
Sbjct: 939 DAETFNKYIPYFLFDLPDAECAKAGRASYADAVIYTIDDVGMSTVQDSYFMQYSTTSTTS 998
Query: 965 EDYINAYKDAQRIVDELN--------DLDVYAYSPFYIFFVQYSTIVSLTAKLITASILL 1016
E++ + ++ +RI E+N D +++AY FYI++ QY TI + S++
Sbjct: 999 EEFYSQLREVRRISGEINAMFKENNVDAEIFAYCVFYIYYEQYLTIWGDAMFSLGMSLVA 1058
Query: 1017 IFFVSWLLLGSAMTS-LILSGIVTMIIVDILAMMYFFGIRLNAVSLVNLLICVGLAVEFC 1075
IF V+ L+ G +TS I+ +V I++++L MM+ + I LNA+SLVNL++CVG+ VEF
Sbjct: 1059 IFLVTLLITGLDITSTFIVLFMVICILINMLGMMWAWSINLNAISLVNLVVCVGIGVEFV 1118
Query: 1076 IHITRAFTIVPVGVKKDRNSRVIYAMTTIGGSVLKGITMTKIIGISVLALTQSKIFQVFY 1135
HI R+F + R +++ G SVL GIT+TK GI VL + S+IFQVFY
Sbjct: 1119 AHIVRSFK----RAEGTAQERARHSLNVTGSSVLSGITLTKFAGIVVLGFSNSQIFQVFY 1174
Query: 1136 FRMWASLIFVASLHALIFLPVLLSMIG 1162
FRM+ ++ + + H LI LPVLLS++G
Sbjct: 1175 FRMYLGIVLIGAAHGLILLPVLLSLLG 1201
Score = 98.2 bits (243), Expect = 7e-20
Identities = 57/186 (30%), Positives = 89/186 (47%), Gaps = 17/186 (9%)
Query: 65 GEEWRDNERLCCTREQMEALKENLNKAESIIASCPACKKNFNTIFCHFTCSPNQRQFIDI 124
GE D LCC Q+E ++ L++A+ + + CP C +N C TC+ N F+
Sbjct: 40 GESGEDELSLCCDAAQIETMESGLSQADGVFSRCPTCTRNMALTVCAMTCAKNHTLFLTA 99
Query: 125 ISTDESSDGREIVSELNFFLNSSWASSFYDSCKNVKFSATNGYAMDLIGGG----ASDYS 180
+ D + G + V +++ L S Y+SC ++ + T AMDL G +Y
Sbjct: 100 YN-DTNDAGVDYVKYIDYRLTDDTVSKIYNSCIGIQHTQTGRPAMDLGCGSYNAKTCNYR 158
Query: 181 EFMKFLGDKKPALGGS--PFQINYEYETSSDEYS---LFDENVFACS---DPKYKCACAD 232
+ +F+GD + G PFQINY++ ++E S D + C + Y CAC D
Sbjct: 159 RWYEFMGD----VSGDYVPFQINYKWSEDAEEGSNEIYLDLSPLKCGESYEDSYACACID 214
Query: 233 CSNSCP 238
C SCP
Sbjct: 215 CEESCP 220
>CE24891 [I] KOG1933 Cholesterol transport protein (Niemann-Pick C disease
protein)
Length = 1274
Score = 274 bits (701), Expect = 5e-73
Identities = 291/1272 (22%), Positives = 526/1272 (40%), Gaps = 162/1272 (12%)
Query: 6 IYVAVALLIHTCYAQESCAMYGNCGK--------KGVFGASLPCPVDADFEPPVIDQGDV 57
+ V LLIH Q C M G+ K LP V P + + +
Sbjct: 12 VSVLFLLLIHLALCQAKCVMTECDGEEDSNHPPCKTNKSTYLPITVTRSLNPTYMARFE- 70
Query: 58 QFLVDICGEEWRDNERLCCTREQMEALKENLNKAESIIASCPACKKNFNTIFCHFTCSPN 117
++ + EE D ++CCT Q++ + + ++ A +I+ SCP+C NF ++C FTCSP+
Sbjct: 71 KYCSYLVQEE--DKAQVCCTELQLKGMTDRISNAATILGSCPSCFDNFAKLWCQFTCSPD 128
Query: 118 QRQFIDIISTDESSDGREIVSELNFFLNSSWASSFYDSCKNVKFSATNGYAMDLIG-GGA 176
Q +F+ ++ E++ + +V ++ F +N + Y+SC++ F+ NG A+ L+ GG
Sbjct: 129 QSKFMKVM---ETTGPKNVVVKMEFKVNRDFVEGLYESCRHTWFA--NGLALRLMSLGGK 183
Query: 177 SDYSEFMKFLGDKKPALGGSPFQINYEYETSSDEYSLFDENVFACSDPKYK-CACADCSN 235
+ F F+G K A P +++ + ++ + PK C DC
Sbjct: 184 VSFENFYGFMGTKNLAQS-IPINTEFQFSRMKNAMNIPTTPCHKSAGPKVPACGAIDCPT 242
Query: 236 SCPTLAPIKKGRCMVAGIPCTSXXXXXXXXXXXXXIGGWHIIIFRRRKIKSTNIVEGSEP 295
+ L I K + + + +++F I + S P
Sbjct: 243 NAHQLVDISKVEHLGTKVFHPHFPDFEWLLKICGCLALTVLLVF----ILKYSCHRRSAP 298
Query: 296 LLDNGNAANSDIDDGLFVEYATERNAMNDKISDVLSNTVAACIKNPITVLSYSXXXXXXX 355
NG +DG +V+ + + + + + A IK+P+ +S
Sbjct: 299 ---NG-------EDGCYVDLG--KGNLEVQFEGLCARYANAVIKHPLIFVSLGLIVAAAC 346
Query: 356 XXXXXVFGDLETDPVNLWVNPSSPKFKEKTHFDANFGPFYRTEQVFIVNDTGPVLSYENL 415
F L + + EK F +FGP +R EQ+FI N S N+
Sbjct: 347 CSGNFKFHSLTHSVDQVSAADGETRRNEKK-FIHSFGPNHRIEQIFI-NLPPTTKSMFNM 404
Query: 416 KWWFETENLI--TENLLS---TENISYQDLCFRPT-EDSTCVIESVTQYFQGI------- 462
+ E L+ +NL + ++ D+C++P ++ C I S T YFQ
Sbjct: 405 PLFEEMFQLVGNIQNLTACYGNSSVKLDDICYKPIGKNHGCAIMSPTNYFQNKWTNFENA 464
Query: 463 --------LPDESSWKQQLESCTDSPV--------NCLPSFQQPLKTNVLFSDEN----- 501
+ D+ W + L+ C +P+ +C F P+ ++F N
Sbjct: 465 GPPTIDDEIFDDQHW-EHLKYCIRNPLTVSTYSEMSCFGEFSGPIDPILVFGGSNESIKG 523
Query: 502 ---VFESNAFVVTLLLSNHTESAKLWEEKLEQYLLSLSIPDGLRISFNTEMSLEKELNSS 558
+ + ++T+L+ + A WE + + +F TE S+ +E++++
Sbjct: 524 AEMYYTARTIMITVLIRGPEDQAIAWETAFLNMMSRYEMKHA-NFTFMTETSVAEEIHTA 582
Query: 559 SD----IIVVSASYLIMFFYASWALKRRTGGS--------RYLLGCAGVLIVFSSVIASS 606
+ + V++ + ++++ + S + L+ + V+I SV S
Sbjct: 583 VETDKIVSVIACAAVLIWVITMLGINHWPESSILSALVHHKLLISISAVMISVISVWCSI 642
Query: 607 GLLSIFGIKSTLILAEVIPFLILAIGIDNIFLITHEFDRVNSH------YSSSTIQEKIV 660
G+ S+FG+ +T V+ F+I +GI+ IF+I F + N H S + +I
Sbjct: 643 GMFSLFGVHATDNAIVVLFFVITCLGINRIFVIIRTF-QANGHCYGLPNISYREMNHRIS 701
Query: 661 LSIGKISPSILFSFLCQGGCFLLA------TMVEMPAVRNFAICAAVALCFNVVLQLTSY 714
+ + P +L + L C LA V MPAV FA A +A+ + L
Sbjct: 702 NVMRRSIPIVLTNSLICSTCLFLAGGVLPYVSVSMPAVEVFARHAGLAILMDTAFYLLVM 761
Query: 715 VCILHFYEK-----------YYDAANVE------ELTDDNEEEGV--LNRTFLSLLDKKR 755
+ + + + +Y+ +N E D N V LL KK
Sbjct: 762 LPLFQYDARREMSGKCEIWPWYELSNESKINLCMEAVDGNLRSPVDWFKLAIAPLLLKKI 821
Query: 756 KVLGV---FFSWFIISLVFLPSIKFGLDQTMAVPQNSYLVNYFQDVYEYLNVGPPVYFVV 812
+ + FF II+ ++FG +Q MA + SYL +FQ++ E LN+GPP++FVV
Sbjct: 822 CRIWIATFFFVSLIIACYCTLCLEFGFNQVMAFSETSYLTKHFQNMNENLNIGPPLWFVV 881
Query: 813 K-NLDLRIKSAQKKICGKFTECDDYSLGNVLE----LERLRSSIVEPLAN-WYDDYMMFL 866
+ ++ Q K C CDD S+GN + E + + + N W D Y+ F+
Sbjct: 882 EGDVKWHDPKMQNKFC-TLAGCDDNSMGNKIRSLAYAENYKGNYLHGDVNIWLDSYLQFM 940
Query: 867 NPELDQCCRLKKGSEEICPPHFPPRRCETCYKDGEWDYDMSGFPEGDEFMKYFDIWINA- 925
+P CC K ++ C P C +C + + EF + ++
Sbjct: 941 HPR-GSCC--KMDGKQFCDPS-NATHCSSCSSSSVASLTTTEY----EFYRNLHHFLETP 992
Query: 926 PSDPCPLGGKSPYSSAIVYNDSNIITSTFRTGHSPLRSQEDYINAYKDAQRIVDELND-- 983
PS C GG + AI + I S + + + D I Y DA R L D
Sbjct: 993 PSIQCAHGGMALAKPAINLTRNGKIQSAYFSTFFKKLNLSDSIQLY-DAWRFAKYLADDI 1051
Query: 984 --------LDVYAYSPFYIFFVQYSTIVSLTAKLITASILLIFFVSWLLLGSAMTSLILS 1035
+ VY YS F+ ++ QY T+ + L ++L+ FV+++ + + +
Sbjct: 1052 ERELEIPGVKVYVYSTFFPYYEQYLTLSTTVYTL----VVLVLFVAFVTISLFLRVNLAG 1107
Query: 1036 GIVTMII-----VDILAMMYFFGIRLNAVSLVNLLICVGLAVEFCIHITRAFTIVPVGVK 1090
+VT+ + + ++ MY GI +N VS++N+ + +G+AVEF + F K
Sbjct: 1108 SLVTVFVLLSSYLHLMEWMYLLGITVNVVSVINMAMSLGIAVEFFGQMLHGFY---NSKK 1164
Query: 1091 KDRNSRVIYAMTTIGGSVLKGITMTKIIGISVLALTQSKIFQVFYFRMWASLIFVASLHA 1150
R R A+ + G + L GI +I L+ S++ ++ + V ++H
Sbjct: 1165 PKREERAFAALVSNGSTTLSGIFPAIMITAGCLSFADSRVLITYFCNQLVGIGLVCAVHG 1224
Query: 1151 LIFLPVLLSMIG 1162
++++P LL++ G
Sbjct: 1225 VVYMPTLLAIFG 1236
>At4g38350 [I] KOG1933 Cholesterol transport protein (Niemann-Pick C disease
protein)
Length = 1054
Score = 273 bits (697), Expect = 2e-72
Identities = 227/815 (27%), Positives = 369/815 (44%), Gaps = 108/815 (13%)
Query: 25 MYGNCGKKGVFGASLPCP-VDADFEPPVIDQGDVQFLVDICGEEWRDNERLCCTREQMEA 83
MY CG + G L CP +P + +Q L + +CCT Q +
Sbjct: 1 MYDICGHRSD-GKVLNCPYASPSIQPDELFSAKIQSLCPTI------SGNVCCTETQFDT 53
Query: 84 LKENLNKAESIIASCPACKKNFNTIFCHFTCSPNQRQFIDIISTDESSDGREIVSELNFF 143
L+ + +A + CPAC +NF +FC +CSPNQ FI++ S E S G V +++
Sbjct: 54 LRSQVQQAVPFLVGCPACLRNFLNLFCELSCSPNQSLFINVTSVAEVS-GNLTVDGIDYH 112
Query: 144 LNSSWASSFYDSCKNVKFSATNGYAMDLIGGGASDYSEFMKFLGDKKPA-LGGSPFQINY 202
+ ++ Y+SCK VKF N A++ +GGGA ++ E+ F+G K P+ GSP+ IN+
Sbjct: 113 ITDTFGEGLYESCKEVKFGTMNTRAINFVGGGAKNFREWFTFIGQKAPSGFPGSPYAINF 172
Query: 203 EYETSSDEYSLFDENVFACSDPKYKCACADCSNSCPTLAPIKKGRCMVAGIP----CTSX 258
+ + + ++ NV Y CAC+ S L P + C + P C
Sbjct: 173 K-SSIPESSAMVPMNVSV-----YSCACS----SPEPLPPHDEDSCSIRIGPLKVRCIEL 222
Query: 259 XXXXXXXXXXXXIGGWHIIIFRRRKIKSTNIVEGSEPLLD--NGNAANSDIDD---GLFV 313
GW + RR +T ++ S+PLL + NS++ + G+ V
Sbjct: 223 SMALVYVLLVSCFFGWAGLNRRRN---TTQPLDSSKPLLHPVEEDGINSEMKENILGVKV 279
Query: 314 EYATERNAMNDKISDVLSNTVAACIKNPITVLSYSXXXXXXXXXXXXVFGDLETDPVNLW 373
+ + + + ++ + + +NP VL S F +ET P LW
Sbjct: 280 QRHAQLSPVQRYMAKFYRSYGSWIARNPSLVLFMSVAIVLALCSGLYNF-KVETRPEKLW 338
Query: 374 VNPSSPKFKEKTHFDANFGPFYRTEQVF--------------IVNDTGPVLSYENLKWWF 419
V P S +EK FD + PFYR EQ+ IV D +L ++ + +F
Sbjct: 339 VGPESKAAEEKKFFDTHLSPFYRIEQLILATVPDPKSGRAPSIVTDENILLLFDIQQKYF 398
Query: 420 ETENLITENLLSTENISYQDLCFRP-TEDSTCVIE-----SVTQYFQGILPDESSWKQQL 473
+ ++ ++ E+ Y CF+ T TC+ + G + S
Sbjct: 399 KMDSGTFDDYGGVEHAEY---CFQHYTSSETCLSAFQAPVDPSAVLGGFSGNNYSEVMVS 455
Query: 474 ESCTDSPVNCLPSFQQPLKTNVLFSDENVFESNAFVVTLLL-------SNHTESAKLWEE 526
E P +C ++ L F++ AFVVT + SN A WE+
Sbjct: 456 ELGCSVPFDCYSDVKRTL-----------FQATAFVVTYPVNNVIGDSSNENARAVAWEK 504
Query: 527 KLEQY----LLSLSIPDGLRISFNTEMSLEKELN--SSSDIIVVSASYLIMFFYASWALK 580
Q LL + L +SF++E S+E+EL S++D+I ++ASYL+MF Y S L
Sbjct: 505 SFIQLAKEELLPMVRSKNLSLSFSSESSIEEELKRESTADVITIAASYLVMFVYISVTLG 564
Query: 581 RRTG------GSRYLLGCAGVLIVFSSVIASSGLLSIFGIKSTLILAEVIPFLILAIGID 634
S+ LLG +GV++V SV+ S G+ S G+KSTLI+ EVIPFL+LA+G+D
Sbjct: 565 DAPQFYTFYISSKVLLGLSGVVLVLLSVLGSVGVFSALGVKSTLIIMEVIPFLVLAVGVD 624
Query: 635 NIFLITHEFDRVNSHYSSSTIQEKIVLSIGKISPSILFSFLCQGGCFLLATMVEMPAVRN 694
N+ ++ H R S ++++I ++ ++ PSI + L + F + V MPA R
Sbjct: 625 NMCILVHAVKRQPREVS---LEQRISSALVEVGPSITLASLSEVLAFAVGAFVPMPACRI 681
Query: 695 FAICAAVALCFNVVLQLTSYVCILHFYEKYYDAANVE------------ELTDDNEEEGV 742
F++ AA+A+ + LQ+T++V ++ F K ++ E + E G
Sbjct: 682 FSMFAALAIMLDFFLQITAFVALIVFDCKRSADNRIDCFPCIKVPSSSRESVEGGREPGF 741
Query: 743 LNR-------TFLSLLDKKRKVLGVFFSWFIISLV 770
L R L L K V+ VFF++ + S++
Sbjct: 742 LERYMKEVHAPVLGLWGVKMVVVAVFFAFALASII 776
Score = 167 bits (422), Expect = 1e-40
Identities = 108/318 (33%), Positives = 164/318 (50%), Gaps = 75/318 (23%)
Query: 849 SSIVEPLANWYDDYMMFLNPELDQCCRLKKGSEEICPPHFPPRRCETCYKDGEWDYDMSG 908
S I +P A+W DD++++L+PE CCR K + CPP + C++ + D
Sbjct: 786 SYIAKPAASWLDDFLVWLSPEAFGCCR-KFTNGSYCPPD------DQCFRHSDLVQDR-- 836
Query: 909 FPEGDEFMKYFDIWINA-PSDPCPLGGKSPYSSAI---VYNDSNIITSTFRTGHSPLRSQ 964
P +F + ++NA PS C GG Y++++ Y I S FRT H+PL +Q
Sbjct: 837 -PSTAQFREKLPWFLNALPSADCAKGGHGAYTNSVDLKGYESGVIQASEFRTYHTPLNTQ 895
Query: 965 EDYINAYKDAQRIVDELNDLDVYAYSPFYIFFVQYSTIVSLTAKLITASILLIFFVSWLL 1024
+D++ YS FYIFF QY I W +
Sbjct: 896 -------------------IDIFPYSVFYIFFEQYLNI-------------------WTV 917
Query: 1025 LGSAMTSLILSGIVTMIIVDILAMMYFFGIRLNAVSLVNLLICVGLAVEFCIHITRAFTI 1084
A+T+L ++ GI+LNAVS+VNL++ +G+AVEFC+HI+ AF +
Sbjct: 918 ---ALTNLAIA----------------IGIQLNAVSVVNLIMSIGIAVEFCVHISHAFLM 958
Query: 1085 VPVGVKKDRNSRVIYAMTTIGGSVLKGITMTKIIGISVLALTQSKIFQVFYFRMWASLIF 1144
DR R A+ T+G SV GIT+TK++G+ VL +S+IF V+YF+M+ +L+
Sbjct: 959 ----SSGDREHRAREALETMGASVFSGITLTKLVGVIVLCFARSEIFVVYYFQMYLALVI 1014
Query: 1145 VASLHALIFLPVLLSMIG 1162
+ LH L+FLPV+LS+ G
Sbjct: 1015 IGFLHGLVFLPVILSLAG 1032
>CE29251 [I] KOG1933 Cholesterol transport protein (Niemann-Pick C disease
protein)
Length = 1383
Score = 231 bits (588), Expect = 7e-60
Identities = 214/918 (23%), Positives = 410/918 (44%), Gaps = 129/918 (14%)
Query: 367 TDPVNLWVNPSSPKFKEKTHFDANFGPFYRTEQVFIVNDT---------GPVLSYENLKW 417
T+ V++W +P S +E+ F+ANFG R +Q+ +++ GPV + +
Sbjct: 378 TNVVDMWSSPRSRARQEEMVFNANFGRPQRYQQIMLLSHRDFQSSGKLYGPVFHKDIFEE 437
Query: 418 WFETENLITENLLSTEN-----ISYQDLCFRPTEDS-TCVIESVTQYFQG---------- 461
F+ N I +ST++ I+ D+C+RP C+I S T YFQG
Sbjct: 438 LFDILNAIKN--ISTQDSDGRTITLDDVCYRPMGPGYDCLIMSPTNYFQGNKEHLDMKSN 495
Query: 462 ----ILPDESS------------WKQQLESCTDSPVN--------CLPSFQQPLKTNVLF 497
+ D+ + W + +C D P++ C+ ++ P N++F
Sbjct: 496 KEETVSEDDDAFDYFSSEATTDEWMNHMAACIDQPMSQKTKSGLSCMGTYGGPSAPNMVF 555
Query: 498 --SDENVFESNAFVVTLLLSNHTE----SAKLWEEKLEQYLLSLSIPDGLRI-SFNTEMS 550
+ N +N+ ++T+L++ TE A+LWE++ ++ I SF E S
Sbjct: 556 GKNSTNHQAANSIMMTILVTQRTEPEIQKAELWEKEFLKFCKEYREKSPKVIFSFMAERS 615
Query: 551 LEKELNSSS--DIIVVSASYLIMFFYASWALKRR----------TGGSRYLLGCAGVLIV 598
+ E+ + + +I+ V + + Y +++L R SR LG V+I
Sbjct: 616 ITDEIENDAKDEIVTVVIALAFLIGYVTFSLGRYFVCENQLWSILVHSRICLGMLSVIIN 675
Query: 599 FSSVIASSGLLSIFGIKSTLILAEVIPFLILAIGIDNIFLITHEF--DRVNSHYSSSTIQ 656
S S G+ S+FGI V F++ +G+ F++ + RV+ Y S
Sbjct: 676 LLSSFCSWGIFSMFGIHPVKNALVVQFFVVTLLGVCRTFMVVKYYAQQRVSMPYMSPDQC 735
Query: 657 EKIV-LSIGKISPSILFSFLCQGGCFLLATMVEMPAVRNFAICAAVALCFNVVLQLTSYV 715
+IV + + P++ S L F + ++PA+R F + A +A+ +VVL T ++
Sbjct: 736 PEIVGMVMAGTMPAMFSSSLGCAFSFFIGGFTDLPAIRTFCLYAGLAVLIDVVLHCTIFL 795
Query: 716 CI--------LHFYEKYYDAANVEEL-----------TDDNEEEGVLNRTFLSLLDKKRK 756
+ L+ +++ +++L TD + + L+ + +
Sbjct: 796 ALFVWDTQRELNGKPEFFFPYQIKDLLGAYLIGRQRATDTFMTQFFHFQVAPFLMHRMTR 855
Query: 757 VLG--VFFSWFIISLVFLPSIKFGLDQTMAVPQNSYLVNYFQDVYEYLNVGPPVYFVVK- 813
++ +F + FI +++ I G DQ+MA + SY+ +F+ + ++ +VGPPV+F V
Sbjct: 856 IITGIIFIASFITTVILSSKISVGFDQSMAFTEKSYISTHFRYLDKFFDVGPPVFFTVDG 915
Query: 814 NLDLRIKSAQKKICGKFTECDDYSLGNVLEL---ERLRSSIVEPLANWYDDYMMFLNPEL 870
LD Q K C F C D S GN++ ++ + + NW D+Y+ +++ +
Sbjct: 916 ELDWHRPDVQNKFC-TFPGCSDTSFGNIMNYAVGHTEQTYLSGEMYNWIDNYLEWISRKS 974
Query: 871 DQCCRLKKGSEEICPPH-----FPPRRCETCYKDGEWDYDMSGFPEG---------DEFM 916
C C + + C TC ++DY + +P+ + F
Sbjct: 975 PCCKVYVHDPNTFCSTNRNKSALDDKACRTCM---DFDYVANSYPKSSIMYHRPSIEVFY 1031
Query: 917 KYFDIWI-NAPSDPCPLGGKSPYSSAIVYND-SNIITSTFRTGHSPL--RSQEDYINAYK 972
++ ++ + P+ C GG++ + AI + I S F T H L + D+I A
Sbjct: 1032 RHLRHFLEDTPNSECVFGGRASFKDAISFTSRGRIQASQFMTFHKKLSISNSSDFIKAMD 1091
Query: 973 DAQRIVDEL-----NDLDVYAYSPFYIFFVQYSTIVSLTAKLITASILLIFFVSWLLLGS 1027
A+ + L + V+AYS + F+ QYSTI+ + + +++ +F + + LG
Sbjct: 1092 TARMVSRRLERSIDDTAHVFAYSKIFPFYEQYSTIMPILTTQLFITVVGVFGIICVTLGI 1151
Query: 1028 AMTSLILSGIVTMI-IVDILAMMYFFGIRLNAVSLVNLLICVGLAVEFCIHITRAFTIVP 1086
+ + I + I+A MY F I +NA+S NL++ G+ +EF +++ + +
Sbjct: 1152 DVKGAACAVICQVSNYFHIVAFMYIFNIPVNALSATNLVMSSGILIEFSVNVLKGYA--- 1208
Query: 1087 VGVKKDRNSRVIYAMTTIGGSVLKGITMTKIIGISVLALTQSKIFQVFYFRMWASLIFVA 1146
+++ R + +IG +L G +T L+ +I V++F+++ I +
Sbjct: 1209 CSLRQRAKDRAESTVGSIGPIILSGPVVTMAGSTMFLSGAHLQIITVYFFKLFLITIVSS 1268
Query: 1147 SLHALIFLPVLLSMIGGK 1164
++HALI LP+LL+ G +
Sbjct: 1269 AVHALIILPILLAFGGSR 1286
Score = 84.0 bits (206), Expect = 1e-15
Identities = 48/157 (30%), Positives = 74/157 (46%), Gaps = 14/157 (8%)
Query: 18 YAQESCAMYGNCGKKGVFGASLPCPV-DADFEPPVIDQGDVQF--LVDICGEEWRDNERL 74
+ C M G C +K A PC D + EP D+ + +V+ C + +L
Sbjct: 17 HGDAGCIMRGLC-QKHTENAYGPCVTNDTNVEPTAFDKTHPAYEKMVEFCPHLLTGDNKL 75
Query: 75 CCTREQMEALKENLNKAESIIASCPACKKNFNTIFCHFTCSPNQRQFIDIIS-------- 126
CCT Q E L + + +A I+ CP+C NF ++C FTCSPNQ+ F+ I
Sbjct: 76 CCTPSQAEGLTKQIAQARHILGRCPSCFDNFAKLWCEFTCSPNQQDFVSISEMKPIEKKE 135
Query: 127 --TDESSDGREIVSELNFFLNSSWASSFYDSCKNVKF 161
T E V+ + + L++ +A + SCK+V F
Sbjct: 136 GFTPEYQPAEAYVNTVEYRLSTDFAEGMFSSCKDVTF 172
>CE08532 [R] KOG1934 Predicted membrane protein (patched superfamily)
Length = 933
Score = 121 bits (303), Expect = 7e-27
Identities = 154/702 (21%), Positives = 296/702 (41%), Gaps = 118/702 (16%)
Query: 524 WEEKLEQYLLSLSIPDGLRISFNTEMSLEKELNSSSDIIV----VSASYLIMF------- 572
WE +L + L + I++ +L EL ++D ++ +S + LI+F
Sbjct: 226 WELELGRMLTQYPEDPYISITYFHSQTLADELKRNADTLIPRFIISITLLIVFSTLCSLS 285
Query: 573 -----FYASWALKRRTGGSRYLLGCAGVLIVFSSVIASSGLLSIFGIKSTLILAEVIPFL 627
F W L S+ +L GV+ +++ G LS+ G+ I+ V+PFL
Sbjct: 286 FIDGSFSIDWVL------SKPILSILGVVSAGIAILTGVGFLSLMGMPYNDIVG-VMPFL 338
Query: 628 ILAIGIDNIFLITHEFDRVNSHYSSSTIQEKIVLSIGKISPSILFSFLCQGGCFLLATMV 687
+LA+G+DN+FL+ R + + T+ E++ + + SIL + F + +
Sbjct: 339 VLAVGVDNMFLMVAAVRRTS---RTHTVHERMGECLADAAVSILITSSTDVLSFGVGAIT 395
Query: 688 EMPAVRNFAICAAVALCFNVVLQLTSYVCILHFYEKY----------YDAANVEELTDDN 737
+PAV+ F + VA+ F + Q+T + L K+ +A + E+ T +
Sbjct: 396 TIPAVQIFCVYTGVAIFFAFIYQITFFAACLALAMKHEASGRNSLFLIEAVSAEKKTSLS 455
Query: 738 EEEGVLNRTFL----SLLDKKRKVLGVFFS------------------WFIISLV----F 771
+ + N + + D K+ + FF WF+I L+
Sbjct: 456 TFQRLFNLGSVPDHSASHDVKQPLTSRFFGEWYAPVLMHPVVRGIAMVWFVIYLLGASYG 515
Query: 772 LPSIKFGLDQTMAVPQNSYLVNYFQDVYEYL-NVGPPVYFVVKNL-DLRIKSAQKKICGK 829
IK GL+ + ++SY + +++ + +Y G V V+ N DLR +++ ++
Sbjct: 516 CSRIKEGLEPVNLLVEDSYAIPHYRLLEKYFWKYGQQVQIVINNAPDLRNHTSRDRVHAM 575
Query: 830 FTECDDYSLGNVLELERLRSSI-VEPLANWYDDYMMFLNPELDQCCRLKKGSEEICPPHF 888
VL+ + +I +E + W + + EL+ ++ S HF
Sbjct: 576 -----------VLDFATSKHAIGMESVQFWLFEMERYYQKELE--VQIIDSSFYGLLHHF 622
Query: 889 PPRRCETCYKDGEWDYDMSGFPEGDEFMKYFDIWINAPSDPCPLGGKSPYSSAIVYNDSN 948
+ P ++ W P D G S + +
Sbjct: 623 LASKTNN--------------PLAEDI-----YWGPMPDDD---NGTMVKSFRFILGMKD 660
Query: 949 IITSTFRTGHSPLRSQEDYINAYKDAQRIVDELNDLDVYAYSPFYIFFVQYSTIVSLTAK 1008
++T+ Q D ++++ E N V + P ++F QY I+ T +
Sbjct: 661 LVTT---------MDQTDATMSFREVAARWPEFN---VTTFMPIWMFTDQYIIIIPNTVQ 708
Query: 1009 LITASILLIFFVSWLLLGSAMTSLILSGIVTMIIVDILAMMYFFGIRLNAVSLVNLLICV 1068
I ++L++ ++ L + M SL ++ I ++ M +G+ L+A+S++ +++ +
Sbjct: 709 NIIIALLVMIVIAVLFIPQPMCSLWVALACASIDFGVIGYMTLWGVNLDAISMITIIMSI 768
Query: 1069 GLAVEFCIHITRAFTIVPVGVKKDRNSRVIYAMTTIGGSVLKGITMTKIIGISVLALTQS 1128
G +V++ HI + V + RV A++ +G + +G M+ II +SVLA +
Sbjct: 769 GFSVDYSAHIAYGYV---VSREDTAAGRVKEALSALGWPLSQG-AMSTIIAVSVLADIPA 824
Query: 1129 KIFQVFYFRMWASLIFVASLHALIFLPVLLSM-IGGKCFIES 1169
+ V +F+ I + LH L+FLPVLLS+ + G C I S
Sbjct: 825 YMI-VTFFKTVVLSISLGLLHGLVFLPVLLSIFVRGCCIIPS 865
>CE12664 [R] KOG1934 Predicted membrane protein (patched superfamily)
Length = 877
Score = 103 bits (256), Expect = 2e-21
Identities = 146/640 (22%), Positives = 256/640 (39%), Gaps = 89/640 (13%)
Query: 562 IVVSASYLIMFFYAS-----WALKRRTGGSRYLLGCAGVLIVFSSVIASSGLLSIFGIKS 616
I+++ +I +Y+S W++ + S +L C L+ SS + G L FG +
Sbjct: 267 IIMTTFSIITIYYSSSRLDQWSVHKV---SEAILACVCPLLATSSAL---GTLFWFGFRF 320
Query: 617 TLILAEVIPFLILAIGIDNIFLITHEFDRVNSHYSSSTIQEKIVLSIGKISPSILFSFLC 676
IL V PFLILAIG+D+ +L H R+ + SS T +EKI + ++ PSI + +
Sbjct: 321 GTILC-VTPFLILAIGVDDAYLQVHACMRLTAEDSSMTKREKIARMLVEVGPSIAITSMT 379
Query: 677 QGGCFLLATMVEMPAVRNFAICAAVALCFNVVLQLTSYVCILHFYEKYYDAANVEELTDD 736
FL+ P + F AVA+ F+ + Q+T Y IL E N + D
Sbjct: 380 NLFAFLVGIYTPTPEISLFCAGNAVAILFDFIYQITMYTAILSICENLEMRKNATKRKDS 439
Query: 737 NEEEGVLNRTFLSLLDK----------KRKVLGVFFSWFIISLVFLPSIKFGLDQTMAVP 786
N F +LD VL F + +S+ +I L V
Sbjct: 440 G--LSFKNEQFTVMLDSYCDWVANAYTHLLVLFCFIVYIFVSIRGALNINIILSPDKLVI 497
Query: 787 QNSYL--VNYFQDVYEYLNVGPPVYFVVKNLDLRIKSAQKKICGKFTECDDY--SLGN-- 840
+S L VNY +D + N FV +L I+S + F + Y LG
Sbjct: 498 GDSPLLQVNYLRDQFVLPNYTTVNIFVQNPGNLTIQSNLDYMNSLFDSFESYPECLGKKF 557
Query: 841 ----VLELERLRSSIVEPLANWYDDYMMFLNPELDQCCRLKKGSEEICPPHFPPRRCETC 896
V + E R S +E + D+ L+ + SE + P F
Sbjct: 558 SHYFVRDYESFRESSLEEMEMMEDEEGDTNKTALEPFSKAAM-SEFLAWPEFQ------- 609
Query: 897 YKDGEWDYDMSGFPEGDEFMKYFDIWINAPSDPCPLGGKSPYSSAIVYNDSNIITSTFRT 956
W +GF + D+ G S Y + + Y+
Sbjct: 610 ----HW----NGFVKFDK-----------------NGMLSKYWATVSYHGE--------- 635
Query: 957 GHSPLRSQEDYINAYKDAQRIVDELNDLDVYAYSPFYIFFVQYSTIVSLTAKLITASILL 1016
G + + +N ++ D+ L+V + + F TI+ T +++
Sbjct: 636 GLGDFQVRRRMLNRWR---ATADQFAPLNVSIFDDYAPFVDTLETILPATISTSVCTLIC 692
Query: 1017 IFFVSWLLLGSAMTSLILSGIVTMIIVDILAMMYFFGIRLNAVSLVNLLICVGLAVEFCI 1076
+ V +L + + T + + +T I + + + +GI L+ +S+ L++ +G +V+F
Sbjct: 693 MMIVCFLFMYNVFTVFVATLAITSICIGVFGFLSMWGIDLDPISMACLIMSIGFSVDFPA 752
Query: 1077 HITRAFTIVPVGVKKDRNS---RVIYAMTTIGGSVLKGITMTKIIGISVLALTQSKIFQV 1133
HIT F G+ +++ RV ++ IG +L+ ++ I+ + L + + +V
Sbjct: 753 HIT--FHYFREGLHDPQSTPAKRVARSLAAIGFPLLQ-CGLSTILFVLCLLFVPTYMGEV 809
Query: 1134 FYFRMWASLIFVASLHALIFLPVLL---SMIGGKCFIESK 1170
F M ++ + +H L +P L + I CF S+
Sbjct: 810 FVKTM-ILVVTLGLIHGLFIVPAFLCAFTAIHQTCFSSSR 848
>7302178 [R] KOG1934 Predicted membrane protein (patched superfamily)
Length = 1061
Score = 101 bits (252), Expect = 6e-21
Identities = 71/235 (30%), Positives = 131/235 (55%), Gaps = 13/235 (5%)
Query: 936 SPYSSAIVYND--SNIITSTFRTGHSPLRSQEDYINAYKDAQRIVDELNDLDVYAYSPFY 993
+P+S + +N+ + II S F + +D ++I + + L+ + P++
Sbjct: 527 NPFSLDVRFNEDETQIIASRFLIQAVNITDTNHEKEMVRDLRQICKD-SPLNASIFHPYF 585
Query: 994 IFFVQYSTI--VSLTAKLITASILLIFFVSWLLLGSAMTSLILSGIVTMIIVDILAMMYF 1051
+FF Q+ + VSL A +I A I++I +S++ + + + SL ++ V I + + M
Sbjct: 586 VFFDQFELVRPVSLQAMVIGAIIMMI--ISFVFIPNILCSLWVAFSVISIELGVAGYMAL 643
Query: 1052 FGIRLNAVSLVNLLICVGLAVEFCIHITRAFTIVPVGVKKDRNSRVIYAMTTIGGSVLKG 1111
+ + L+++S++NL++C+G +V+F HI + K+ +RV A+ ++G +++G
Sbjct: 644 WDVNLDSISMINLIMCIGFSVDFTAHICYTYM---SSKKRSPKARVREALHSLGLPIIQG 700
Query: 1112 ITMTKIIGISVLALTQSKIFQVFYFRMWASLIFVASLHALIFLPVLLSMIG-GKC 1165
+ T I+GI L L QS IF VF F+M +IF ++H L LPVLLS+ G G C
Sbjct: 701 SSST-ILGIVALLLAQSYIFLVF-FKMVFLVIFFGAMHGLFLLPVLLSLFGPGSC 753
>CE06861 [R] KOG1934 Predicted membrane protein (patched superfamily)
Length = 956
Score = 96.7 bits (239), Expect = 2e-19
Identities = 57/208 (27%), Positives = 113/208 (53%), Gaps = 6/208 (2%)
Query: 954 FRTGHSPLRSQEDYINAYKDAQRIVDELNDLDVYAYSPFYIFFVQYSTIVSLTAKLITAS 1013
F+ G R+ D+ ++ K + I D+ + +V + +Y F QY + + + +
Sbjct: 723 FQLGLRNYRTPTDHTHSCKLMRSIADKYSMFNVTTFHEYYPFADQYLELTPSLFQNMISD 782
Query: 1014 ILLIFFVSWLLLGSAMTSLILSGIVTMIIVDILAMMYFFGIRLNAVSLVNLLICVGLAVE 1073
+ IF VSW+++ + ++ + + I V +L M F+G+ L++VS++ +++C+G +V+
Sbjct: 783 LCTIFAVSWVMIPELICAVAIVLSIASINVGVLGFMSFWGVNLDSVSIITVIMCIGFSVD 842
Query: 1074 FCIHITRAFTIVPVGVKKDRNSRVIYAMTTIGGSVLKGITMTKIIGISVLALTQSKIFQV 1133
HI AF+ + ++R + A+ T+G V G + T ++GI +L L S I Q+
Sbjct: 843 LSAHIAYAFS----QSYGNSHARAVAALETLGWPVFLGASST-VLGILLLTLVDSYIVQI 897
Query: 1134 FYFRMWASLIFVASLHALIFLPVLLSMI 1161
F+ ++ + F + LH LIFLP+ L +
Sbjct: 898 FFKTVFLVINF-SILHGLIFLPIFLMKV 924
Score = 59.7 bits (143), Expect = 3e-08
Identities = 56/203 (27%), Positives = 92/203 (44%), Gaps = 19/203 (9%)
Query: 524 WEEKLEQYLLSLSIP--DGLRISFNTEMSLEKELNSSSDII----VVSASYLIMF-FYAS 576
W KL +L P + L N M+L + L +D + V + + L F F S
Sbjct: 246 WRRKLSMWLTDKENPVSELLEFGVNHNMTLPEGLQDVADTLAPKFVGTCAILFTFSFLVS 305
Query: 577 WAL-KRRTGG-------SRYLLGCAGVLIVFSSVIASSGLLSIFGIKSTLILAEVIPFLI 628
L K RTG S+ L+ AG++ + + S GL+ G I+ V PFLI
Sbjct: 306 VVLRKHRTGQVMPDWVRSKPLVAAAGLMTPIMATVTSFGLILWCGFLYNAIV-NVSPFLI 364
Query: 629 LAIGIDNIFLITHEFDRVNSHYSSSTIQEKIVLSIGKISPSILFSFLCQGGCFLLATMVE 688
L IGID++F++ E+ R N +S +++I ++ + + +I + L F +
Sbjct: 365 LCIGIDDLFIMCAEWHRTNPQHSP---EKRIGKTLSEAAVAISITSLTDIATFAMGCYTT 421
Query: 689 MPAVRNFAICAAVALCFNVVLQL 711
+P V+ F + V F V Q+
Sbjct: 422 LPGVQMFCMYTCVQCFFCYVYQI 444
>CE19144 [R] KOG1934 Predicted membrane protein (patched superfamily)
Length = 1003
Score = 91.7 bits (226), Expect = 6e-18
Identities = 57/185 (30%), Positives = 100/185 (53%), Gaps = 5/185 (2%)
Query: 976 RIVDELNDLDVYAYSPFYIFFVQYSTIVSLTAKLITASILLIFFVSWLLLGSAMTSLILS 1035
R + E ++L Y+ F+ F QY+ ++ T I + + + VS +L+ + SL +S
Sbjct: 678 RRLAETSELQTGVYADFFQFAEQYNAVLPGTLSSIAYAGVAVVAVSLILIPEPVASLWVS 737
Query: 1036 GIVTMIIVDILAMMYFFGIRLNAVSLVNLLICVGLAVEFCIHITRAFTIVPVGVKKDRNS 1095
+ I + IL M F+ +RL+ +S+V +++ +G V+F H+ F G D +
Sbjct: 738 FSIVSINIGILGFMTFWSVRLDFISMVTIVMSIGFCVDFAAHLAYNFA---KGQNMDGSE 794
Query: 1096 RVIYAMTTIGGSVLKGITMTKIIGISVLALTQSKIFQVFYFRMWASLIFVASLHALIFLP 1155
R+ A+ +G +L T T IIG+S +A +S +F+ F + +I + +LH L+ LP
Sbjct: 795 RMRNALYAVGAPILMSATST-IIGVSFMASAESYVFRSF-LKTIMLVILLGALHGLVILP 852
Query: 1156 VLLSM 1160
VLLSM
Sbjct: 853 VLLSM 857
Score = 65.9 bits (159), Expect = 4e-10
Identities = 106/509 (20%), Positives = 204/509 (39%), Gaps = 99/509 (19%)
Query: 374 VNPSSPKFKEKTHFDANFGPFYRTEQVFIVNDTGPVLSYENLKWWFETENLITENLLSTE 433
+N S P + + + G T Q + P++ + ++ W ++L E+
Sbjct: 78 INDSDPFYATRRYDIRRAGYIIVTNQEEDGDILNPLVMHSAMQLWSIVQSLTVEDE-DDR 136
Query: 434 NISYQDLC----------------FRP---TEDSTCVIESVTQYFQGIL-PDESSWKQQL 473
I+Y +C F P T + CV + + F+ +L D S + +
Sbjct: 137 RINYPSICVKFPIPPEFSKALHSLFAPNMTTPEEICVSNPLVEIFKLLLVSDRSFLNRSI 196
Query: 474 ESCTDSPVNCLPSFQQPLKTNVLFS-----DENVFESNAFVVTLLLSNHTES----AKLW 524
+ T S ++ F T++L D+ + + A ++ L + ++ A+ W
Sbjct: 197 DEMTLSQISDAIQFDSGGMTHLLGGVTLDDDKRIAGAKAMLLPYALRHSSDDEDWVAEKW 256
Query: 525 EEKLEQYLLSLSIPDGLRISFNTEMSLEKELNSSSD-----------IIVVSASYLIMFF 573
E +L +LL P +R S+ T +L E S+ D + VS +
Sbjct: 257 EVRLADFLLQYDSPI-IRASWWTYETLAAE--SARDRLQLIHMLLPCFVCVSIFTIACCC 313
Query: 574 YASWALKRRTGGSRYLLGCAGVLIVFSSVIASSGLLSIFGIKSTLILAEVIPFLILAIGI 633
SW RR SR L GV+ ++ ++ G+L + G T + A +PF++ ++G+
Sbjct: 314 VFSW---RR---SRPWLAIGGVISAAMAIASAVGILLLAGYGMTSV-AYSMPFIVFSVGV 366
Query: 634 DNIFLITHEFDRVNSHYSSSTIQEKIVLSIGKISPSILFSFLCQGGCFLLATMVEMPAVR 693
DN+F++ + S S+ T++ ++ + + SI + L F + P+V+
Sbjct: 367 DNVFILLSAW---RSTSSTETLEHRMKETFADAAVSITVTSLTDLISFGVGCATPFPSVQ 423
Query: 694 NFAICAAVALCFNVVLQLTSYVCILHFYEK---------YYDAANVEELTDDNEEEGVLN 744
F A A+ F + QLT + ++ + + ++ + L + +G +
Sbjct: 424 MFCAYAVAAVIFTYIYQLTFFAAVMVYTNRREINNRHCIFFHKLKKDTLPEKIAAQG--D 481
Query: 745 RTFLSLLDKKRKVLGVFF----SWFIIS----LVFL--------------PSIKFGLDQT 782
R+F +K +L FF S F+++ +V L +K GL+
Sbjct: 482 RSF-----EKNTILAQFFRTTYSDFLLNPLVRIVILVTFCVYLGVASYGCTKVKLGLEPN 536
Query: 783 MAVPQNSY-------LVNYFQDVYEYLNV 804
+P+NSY YF D L+V
Sbjct: 537 DLLPENSYGKRTLMMAEKYFSDYGSSLHV 565
>CE05777 [R] KOG1934 Predicted membrane protein (patched superfamily)
Length = 955
Score = 91.7 bits (226), Expect = 6e-18
Identities = 99/428 (23%), Positives = 193/428 (44%), Gaps = 58/428 (13%)
Query: 760 VFFSWFIISLVFLPSIKFGLDQTMAVPQNSYLVNYFQDVYEYLNVGPPVYFVVKNL-DLR 818
+F + I++ + + GL+ V + Y+ YF D+ + +G ++ V N +L
Sbjct: 568 IFVVYLAIAMYGCYNFREGLNPGNLVTNDHYIAKYFSDIKHFWRIGAQLHVAVLNPPNLT 627
Query: 819 IKSAQK---KICGKFTECDDYSLGNVLELERLRSSIVEPLANWYDDYMMFLNPELDQCCR 875
I + K+ F E Y+LG R V L Y +Y+ LN E++ R
Sbjct: 628 ISENRNELLKVVSAF-ENTQYTLG--------REGTVFFLLE-YLNYLSELNAEVEDTER 677
Query: 876 LKK----------GSEEICPPHFPPRRCETCYKDGEWDYDMSGFPEGDEFMKYFDIWINA 925
L K G + + + ++ + + F E ++ K+ +
Sbjct: 678 LWKTKLNSWLKYTGGSTQWASNLKINKTDGSFQAFRFQIALKNFVEPNDH-KHAAQLLRD 736
Query: 926 PSDPCPLGGKSPYSSAIVYNDSNIITSTFRTGHSPLRSQEDYINAYKD-AQRIVDELNDL 984
+D P + +VY++ + G+ + + D+I+++ AQ+ + +L
Sbjct: 737 IADHQPF-------NVVVYHEVSF-------GNRKILN--DFISSHSCYAQKNIPKLA-- 778
Query: 985 DVYAYSPFYIFFVQYSTIVSLTAKLITASILLIFFVSWLLLGSAMTSLILSGIVTMIIVD 1044
+ F QY I+ T + + S+L + VS+LL+ S + ++ + I +
Sbjct: 779 --------FPFADQYLIILPATIQNVVISLLCMAVVSFLLVPSLPSGFVIFVSIVSINIG 830
Query: 1045 ILAMMYFFGIRLNAVSLVNLLICVGLAVEFCIHITRAFTIVPVGVKKDRNSRVIYAMTTI 1104
+ M +G+ L+AVS++++++ +G AV+ HI AF V D RVI A+ T+
Sbjct: 831 VFGYMTLWGVNLDAVSMISIIMSIGFAVDLSAHIIYAF----VTSHGDTKQRVIGALETL 886
Query: 1105 GGSVLKGITMTKIIGISVLALTQSKIFQVFYFRMWASLIFVASLHALIFLPVLLSMIGGK 1164
G + +G + T I GIS+L + I VF+ +W +++ + ++H L F+P+ LS+ +
Sbjct: 887 GWPIFQGASST-IAGISILYTVDAYIILVFFKTIWLTML-IGAIHGLFFIPIFLSLFPVE 944
Query: 1165 CFIESKSN 1172
F KS+
Sbjct: 945 FFRIPKSS 952
Score = 64.3 bits (155), Expect = 1e-09
Identities = 76/335 (22%), Positives = 146/335 (42%), Gaps = 52/335 (15%)
Query: 416 KWWFETENLITENLLSTENISYQDLCFRPTEDSTCVIESVTQYFQGILPDESSWKQQLES 475
+W ++ T++L N++YQDLC + D C ++ Q +L + +
Sbjct: 121 QWIMNNISIPTDDLKF--NLTYQDLCL--SYDWVC---GANEHIQMLLR-----RNDVNQ 168
Query: 476 CTDSPVNCLPSFQQPLKTNVLFSDENVFESNAFV---VTLLLSNHTESAKLWEE------ 526
D + P+ +F D F++ +T L + K+ EE
Sbjct: 169 ILDLHFPRGGTKDTPVYLGGIFGDVQFFQNGTLSDAKLTQLFYFLKQDQKMVEEYSSKFS 228
Query: 527 -KLEQYLLSLSIPDGLRISFNTEMSLEKELNSSSDIIVVS--ASYLIMFFYA---SWALK 580
LE +L + D + +SF SLE L+ ++ V + S+ ++ YA S+ LK
Sbjct: 229 YALETFLNQVYSSDVITLSFAHYQSLEDGLDENAKAFVPNFVVSFFVLAMYALVSSFTLK 288
Query: 581 RRTG------GSRYLLGCAGVLIVFSSVIASSGLLSIFGIKSTLILAEVIPFLIL----- 629
+ S+ L AG+ S+I++ G L I G++ +I +IPFLI+
Sbjct: 289 SSSATKIDWISSKPWLAAAGMFSTVLSIISAFGFLFILGVRYNVINT-IIPFLIIGEFQS 347
Query: 630 ----------AIGIDNIFLITHEFDRVNSHYSSSTIQEKIVLSIGKISPSILFSFLCQGG 679
AIGID++FL+ +D+ + S ++ E++ ++ ++ + +
Sbjct: 348 FKNMEKNQIPAIGIDDMFLMNACWDQTSK---SLSVPERMSKTLSHAGVAVTITNVTDVM 404
Query: 680 CFLLATMVEMPAVRNFAICAAVALCFNVVLQLTSY 714
F + + ++P ++ F I A V++ F+ QLT +
Sbjct: 405 SFAIGCITDLPGIQFFCIYACVSVAFSYFYQLTFF 439
>CE29399 [R] KOG1934 Predicted membrane protein (patched superfamily)
Length = 870
Score = 91.3 bits (225), Expect = 8e-18
Identities = 63/232 (27%), Positives = 119/232 (51%), Gaps = 10/232 (4%)
Query: 945 NDSNIITSTFR--TGHSPLRSQEDYINAYKDAQRIVDELNDLDVYAYSPFYIFFVQYSTI 1002
N+S I TFR G + + A + I +V Y P ++F QY+ +
Sbjct: 634 NNSERIIKTFRFMIGMRDISTTTKQTEATNTFREIASRFEQYNVTTYMPLWLFTDQYALV 693
Query: 1003 VSLTAKLITASILLIFFVSWLLLGSAMTSLILSGIVTMIIVDILAMMYFFGIRLNAVSLV 1062
V T + I ++ + +S LL+ + S ++ + I + +L M + + L+A+S++
Sbjct: 694 VPNTMQDIIVAVACMLVISALLIPQPVCSFWVAVTIGSIDLGVLGFMTLWNVNLDAISMI 753
Query: 1063 NLLICVGLAVEFCIHITRAFTIVPVGVKKDRNSRVIYAMTTIGGSVLKGITMTKIIGISV 1122
+++ VG +V++ HIT A+ I + ++RV A+ +G V +G M+ I+ +SV
Sbjct: 754 TIIMSVGFSVDYSAHITYAYVI---SKESTTSARVCDALGDLGWPVAQG-AMSTILAVSV 809
Query: 1123 LALTQSKIFQVFYFRMWASLIFVASLHALIFLPVLLSMIGGKCF---IESKS 1171
L+ + + F+ ++ + I + LH L+FLP++LS+ G C IE+KS
Sbjct: 810 LSDVPAYMIVTFFKTVFLA-ISIGFLHGLVFLPLMLSVFVGCCSSNKIETKS 860
Score = 59.7 bits (143), Expect = 3e-08
Identities = 53/215 (24%), Positives = 98/215 (44%), Gaps = 21/215 (9%)
Query: 523 LWEE----KLEQYLLSLSIPDGLRISFNTEMSLEKELNSSSDIIVVS--ASYLIMFFYAS 576
LWE K+++Y + I++ +L ELN +++ + +++I+ ++
Sbjct: 197 LWEREFKNKMDEYKKQAKY---ISITYFHSQTLSDELNRNAERLAPKFIGAFVILVCFSV 253
Query: 577 WALKRRTGGSRYL--------LGCAGVLIVFSSVIASSGLLSIFGIKSTLILAEVIPFLI 628
GS Y+ L GV + ++ G+L+ I+ I+A V+PFL+
Sbjct: 254 LCSIVTIKGSGYIDWVVTKPILSVLGVSNAGMGIASAMGMLTYLEIQYNDIIA-VMPFLV 312
Query: 629 LAIGIDNIFLITHEFDRVNSHYSSSTIQEKIVLSIGKISPSILFSFLCQGGCFLLATMVE 688
+A+G DN+FL+ R + + ++I + + SIL + L F + T+
Sbjct: 313 VAVGTDNMFLMVASLKRTDRNLK---YDQRIAECMADAAVSILITALTDALSFGVGTITT 369
Query: 689 MPAVRNFAICAAVALCFNVVLQLTSYVCILHFYEK 723
+PAV+ F I AL QLT + IL +Y +
Sbjct: 370 IPAVQIFCIYTMCALLLTFAYQLTFFCAILVYYTR 404
>CE23110 [R] KOG1934 Predicted membrane protein (patched superfamily)
Length = 859
Score = 89.4 bits (220), Expect = 3e-17
Identities = 141/657 (21%), Positives = 265/657 (39%), Gaps = 125/657 (19%)
Query: 561 IIVVSASYLIMFFYASWALKRRTGGSRYLLGCAGVLIVFSSVIASSGLLSIFGIKSTLIL 620
++V S L+++F + R S+ L C G LI S I + G++S G+ I+
Sbjct: 229 LMVCSLRPLMIYF------RYRRAESKPLEACLGALIPVLSGITTIGMVSATGLAFQSII 282
Query: 621 AEVIPFLILAIGIDNIFLITHEFDRVNSHYSSSTIQEKIVLSIGKISPSILFSFLCQGGC 680
+ FL++AIGID+IF+I + R + H I E++ L++ + S+ + +
Sbjct: 283 VSTL-FLVIAIGIDDIFIILAAWHRTDKHLE---IPERMALTVQEAGCSMTVTTVTNLVS 338
Query: 681 FLLATMVEMPAVRNFAICAAVALCFNVVLQLTSYVCIL-----HFYEKYYDAANVEELTD 735
F + P ++ FAI ++VA + QL + I+ + Y+K D+ EE T
Sbjct: 339 FGNGVLSTTPVLQTFAIYSSVASVVCYIYQLVIFPAIIAITAPNEYQKLGDSK--EEKTW 396
Query: 736 D-------------NEEEGVLNRTFLSLLDKKRKVLGVFFSWFIISLVFLPSIKFGLDQT 782
D ++ G ++ +++ LL + + ++ +S+ + +++ L
Sbjct: 397 DIIKTMGQWSDRQWHKLAGAISTSWVRLL-----TISILLGYWYLSVYGIATMETDLTIQ 451
Query: 783 MAVPQNSYLVNYFQDVYEYLNVGPPVYFVVKN-LDLR----IKSAQKKICGKFTECDDYS 837
QN+ +V + +D L V +VK+ DLR +K QK I K E S
Sbjct: 452 KMADQNARIVKFKRDADIILKEMQSVAILVKSPKDLRKMENLKKLQKMI--KDFESAKNS 509
Query: 838 LGNVLELERLRSSIVEPLANWYDDYMMFLNPELDQCCRLKKGSEEICPPHFPPRRCETCY 897
GN E W Y+ FL T Y
Sbjct: 510 FGN------------ESTVCWLQSYIDFL----------------------------TFY 529
Query: 898 KDGEWDYD-----------MSGFPEGDEFMKYFDIWINAPSDPCPLGGKSPYSSAIVYND 946
++ + ++D S F E F + P L + Y I Y++
Sbjct: 530 QENDEEFDNDDVITENSAKKSNFSEEKPAKSRFQFTYS--DLPAFLNSEPQYKPMIRYSE 587
Query: 947 SNIITST--------FRTGHSPLRSQEDYINAYKDAQRIVDELNDLDVYAYSPFYIFFVQ 998
S + ++ F TG + + + + ++I ++ +VY Y+ F Q
Sbjct: 588 SECVKNSEKCIESFIFTTGFTDVVKYNEMYPVVSEWRKIAANYSEFEVYPYTERSNFVDQ 647
Query: 999 YSTIV-----SLTAKLITASILLIFFVSWLLLGSAMTSLILSGIVTMIIVD--ILAMMYF 1051
+V ++ +++I + I F+ L+ I S + + V+ + +
Sbjct: 648 TVDMVDNIWNTVISEVICMGLTFILFIPDLI-------SIFSAVFALFSVNFGVFGFLSI 700
Query: 1052 FGIRLNAVSLVNLLICVGLAVEFCIHITRAFTIVPVGVKKDRNSRVIYAMTTIGGSVLKG 1111
+G+ ++ VS +LL+ +G +V+ HI+ + V K ++ + + IG L+G
Sbjct: 701 WGVGMDPVSTASLLMSIGFSVDISAHISYHYYQVD---KPTARQKLEHVYSHIGWPTLQG 757
Query: 1112 ITMTKIIGISVLALTQSKIFQVFYFRMWASLIFVASLHALIFLPVLLSM---IGGKC 1165
++ ++ + + L S + VF + F +H LI LPV LS I G C
Sbjct: 758 -GLSTMLAMMPIVLAPSYLGMVFLKTVILVCTF-GLIHGLIVLPVFLSFFTEISGFC 812
>Hs4506247_1 [T] KOG1935 Membrane protein Patched/PTCH
Length = 1390
Score = 89.0 bits (219), Expect = 4e-17
Identities = 57/179 (31%), Positives = 95/179 (52%), Gaps = 5/179 (2%)
Query: 543 ISFNTEMSLEKELNSSSDIIV--VSASYLIMFFYASWALKR-RTGGSRYLLGCAGVLIVF 599
+SF T +L+ L S SD+ V V++ YL+M YA + R S+ +G AGVL+V
Sbjct: 420 LSFTTT-TLDDILKSFSDVSVIRVASGYLLMLAYACLTMLRWDCSKSQGAVGLAGVLLVA 478
Query: 600 SSVIASSGLLSIFGIKSTLILAEVIPFLILAIGIDNIFLITHEFDRVNSHYSSSTIQEKI 659
SV A GL S+ GI +V+PFL L +G+D++FL+ H F + +++
Sbjct: 479 LSVAAGLGLCSLIGISFNAATTQVLPFLALGVGVDDVFLLAHAFSETGQN-KRIPFEDRT 537
Query: 660 VLSIGKISPSILFSFLCQGGCFLLATMVEMPAVRNFAICAAVALCFNVVLQLTSYVCIL 718
+ + S+ + + F +A ++ +PA+R F++ AAV + FN + L + IL
Sbjct: 538 GECLKRTGASVALTSISNVTAFFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAIL 596
Score = 88.6 bits (218), Expect = 5e-17
Identities = 59/204 (28%), Positives = 105/204 (50%), Gaps = 7/204 (3%)
Query: 961 LRSQEDYINAYKDAQRIVDELNDLDVYAYSPFY--IFFVQYSTIVSLTAKLITASILLIF 1018
LR D++ A + + I L + +Y Y +F+ QY + I+ + F
Sbjct: 981 LRDTSDFVEAIEKVRTICSNYTSLGLSSYPNGYPFLFWEQYIGLRHWLLLFISVVLACTF 1040
Query: 1019 FVSWLLLGSAMTSLILSGIVTMIIVDILAMMYFFGIRLNAVSLVNLLICVGLAVEFCIHI 1078
V + L + T+ I+ ++ ++ V++ MM GI+L+AV +V L+ VG+ VEF +H+
Sbjct: 1041 LVCAVFLLNPWTAGIIVMVLALMTVELFGMMGLIGIKLSAVPVVILIASVGIGVEFTVHV 1100
Query: 1079 TRAFTIVPVGVKKDRNSRVIYAMTTIGGSVLKGITMTKIIGISVLALTQSKIFQVFYFRM 1138
AF + +G D+N R + A+ + VL G T ++G+ +LA ++ ++F +
Sbjct: 1101 ALAF-LTAIG---DKNRRAVLALEHMFAPVLDGAVST-LLGVLMLAGSEFDFIVRYFFAV 1155
Query: 1139 WASLIFVASLHALIFLPVLLSMIG 1162
A L + L+ L+ LPVLLS G
Sbjct: 1156 LAILTILGVLNGLVLLPVLLSFFG 1179
>Hs4506245 [T] KOG1935 Membrane protein Patched/PTCH
Length = 1203
Score = 85.5 bits (210), Expect = 4e-16
Identities = 59/205 (28%), Positives = 104/205 (49%), Gaps = 9/205 (4%)
Query: 961 LRSQEDYINAYKDAQRIVDELNDLDVYAY---SPFYIFFVQYSTIVSLTAKLITASILLI 1017
L+ D++ A + A+ E V+AY SPF +F+ QY + + ++
Sbjct: 917 LQKTADFVEAIEGARAACAEAGQAGVHAYPSGSPF-LFWEQYLGLRRCFLLAVCILLVCT 975
Query: 1018 FFVSWLLLGSAMTSLILSGIVTMIIVDILAMMYFFGIRLNAVSLVNLLICVGLAVEFCIH 1077
F V LLL + T+ ++ ++ M+ V++ +M F GI+L+A+ +V L+ VG+ VEF +H
Sbjct: 976 FLVCALLLLNPWTAGLIVLVLAMMTVELFGIMGFLGIKLSAIPVVILVASVGIGVEFTVH 1035
Query: 1078 ITRAFTIVPVGVKKDRNSRVIYAMTTIGGSVLKGITMTKIIGISVLALTQSKIFQVFYFR 1137
+ F + + RN R +A+ V G T ++G+ +LA + ++F
Sbjct: 1036 VALGF----LTTQGSRNLRAAHALEHTFAPVTDGAIST-LLGLLMLAGSHFDFIVRYFFA 1090
Query: 1138 MWASLIFVASLHALIFLPVLLSMIG 1162
L + LH L+ LPVLLS++G
Sbjct: 1091 ALTVLTLLGLLHGLVLLPVLLSILG 1115
Score = 77.8 bits (190), Expect = 9e-14
Identities = 55/200 (27%), Positives = 103/200 (51%), Gaps = 9/200 (4%)
Query: 524 WEEKLEQYLLSLSIPDGL--RISFNTEMSLEKELNSSSDIIV--VSASYLIMFFYASWAL 579
W+ + Q L ++P+ +I + +L+ L++ S++ V YL+M YA +
Sbjct: 355 WQRRFVQ-LAQEALPENASQQIHAFSSTTLDDILHAFSEVSAARVVGGYLLMLAYACVTM 413
Query: 580 KR-RTGGSRYLLGCAGVLIVFSSVIASSGLLSIFGIKSTLILAEVIPFLILAIGIDNIFL 638
R S+ +G AGVL+V +V + GL ++ GI +V+PFL L IG+D++FL
Sbjct: 414 LRWDCAQSQGSVGLAGVLLVALAVASGLGLCALLGITFNAATTQVLPFLALGIGVDDVFL 473
Query: 639 ITHEFDRVNSHYSSSTIQEKIVLSIGKISPSILFSFLCQGGCFLLATMVEMPAVRNFAIC 698
+ H F + +QE++ + + S++ + + FL+A +V +PA+R F++
Sbjct: 474 LAHAFTEA---LPGTPLQERMGECLQRTGTSVVLTSINNMAAFLMAALVPIPALRAFSLQ 530
Query: 699 AAVALCFNVVLQLTSYVCIL 718
AA+ + V + + IL
Sbjct: 531 AAIVVGCTFVAVMLVFPAIL 550
>CE01865 [R] KOG1934 Predicted membrane protein (patched superfamily)
Length = 1015
Score = 85.1 bits (209), Expect = 6e-16
Identities = 54/221 (24%), Positives = 113/221 (50%), Gaps = 12/221 (5%)
Query: 944 YNDSNIITSTFRTGHSPLRSQEDYINAYKDAQRIVDELNDLDVYAYSPFYIFFVQYSTIV 1003
Y+ + + FR G L + D + ++ + + D DL++ Y Q + I+
Sbjct: 763 YDTLELKSYRFRIGVHRLSTPTDLVLITEELRGVADRHPDLNIVTYQQSRAIADQLNVIL 822
Query: 1004 SLTAKLITASILLIFFVSWLLLGSAMTSLILSGIVTMIIVDILAMMYFFGIRLNAVSLVN 1063
S T T ++ +F V+ + + + + +L ++ + I + ++ + + ++L+ +S++
Sbjct: 823 SSTITNDTLAMFCMFCVALIFIPNPICALFITFAMVTIDIGVIGFLSLWSVKLDPISMIT 882
Query: 1064 LLICVGLAVEFCIHITRAFTIVPVGVKKDRN----SRVIYAMTTIGGSVLKGITMTKIIG 1119
+++ +G ++EF HIT F V D N R + AM + V+ G +++ I+G
Sbjct: 883 IIMSIGFSIEFSAHITHGF------VSNDSNLSAFDRCVDAMEKLAWPVVHG-SLSTILG 935
Query: 1120 ISVLALTQSKIFQVFYFRMWASLIFVASLHALIFLPVLLSM 1160
+ VLA S + VF F+ + ++ + + HAL+ LP+LLSM
Sbjct: 936 VFVLAFIDSYMVLVF-FKTISLVLIIGAWHALMLLPILLSM 975
Score = 58.2 bits (139), Expect = 8e-08
Identities = 48/217 (22%), Positives = 99/217 (45%), Gaps = 20/217 (9%)
Query: 521 AKLWEEKLEQYLLSL-----SIPDGLRISFNTEMSLEKELNSSSDIIVVSASYLIMF--F 573
AK WE+ E+++ +I ++ S + L + N V+ + L++F F
Sbjct: 289 AKFWEDTAEKFVRETYADHPTIQCHIKHSRIVDQGLTRNANRLKPYFNVTIAVLVLFTAF 348
Query: 574 YA---------SWALKRRTGGSRYLLGCAGVLIVFSSVIASSGLLSIFGIKSTLILAEVI 624
Y+ SW L S+ +L GVL ++++ GLL FG+ I +
Sbjct: 349 YSVKWYFRMDHSWPLHIDWLRSKPMLALGGVLSSVLAILSGIGLLLWFGMFFAEITL-IA 407
Query: 625 PFLILAIGIDNIFLITHEFDRVNSHY---SSSTIQEKIVLSIGKISPSILFSFLCQGGCF 681
PFL+L+IG+D++F+ + Y S ++++++ ++ + + +I + F
Sbjct: 408 PFLVLSIGVDDMFIAVAAWHNTEMKYPGRSPKVMKKRMIEAMSESAVAIFITSFTDVLSF 467
Query: 682 LLATMVEMPAVRNFAICAAVALCFNVVLQLTSYVCIL 718
T+ ++ AV+ F A + F + Q+T + ++
Sbjct: 468 GAGTITDIIAVQGFCAMTAACMFFTFLYQITFFAALM 504
>7304020 [T] KOG1935 Membrane protein Patched/PTCH
Length = 1286
Score = 84.0 bits (206), Expect = 1e-15
Identities = 49/168 (29%), Positives = 88/168 (52%), Gaps = 7/168 (4%)
Query: 551 LEKELNSSSDIIVVSASYLIMFFYASWALKRRTGGSRYLLGCAGVLIVFSSVIASSGLLS 610
L K + S+ IV+ + +++ + + R + +G AGVL++ S A GL +
Sbjct: 421 LAKFSHPSALSIVIGVAVTVLYAFCTLLRWRDPVRGQSSVGVAGVLLMCFSTAAGLGLSA 480
Query: 611 IFGIKSTLILAEVIPFLILAIGIDNIFLITHEFDRVNSHYSSSTIQEKIVLSIGKISPSI 670
+ GI +V+PFL L +G+D+IF++T + Y+ S +E+ L + K+ PSI
Sbjct: 481 LLGIVFNAASTQVVPFLALGLGVDHIFMLT-------AAYAESNRREQTKLILKKVGPSI 533
Query: 671 LFSFLCQGGCFLLATMVEMPAVRNFAICAAVALCFNVVLQLTSYVCIL 718
LFS G F A + +PA++ F + AA+ +C N+ L + ++
Sbjct: 534 LFSACSTAGSFFAAAFIPVPALKVFCLQAAIVMCSNLAAALLVFPAMI 581
Score = 61.2 bits (147), Expect = 9e-09
Identities = 49/172 (28%), Positives = 87/172 (50%), Gaps = 9/172 (5%)
Query: 993 YIFFVQYSTIVSLTAKLITASILLIFFVSWLLLGSAMTSLILSGIVTMIIVDILAMMYFF 1052
+IF+ QY T+ S A ++ +L + LLL S ++++ V + I M
Sbjct: 943 FIFWEQYMTLRSSLAMILACVLLAALVLVSLLLLSVWAAVLVILSVLASLAQIFGAMTLL 1002
Query: 1053 GIRLNAVSLVNLLICVGLAVEFCIHITRAFTIVPVGVKKDRNSRVIYAMTTIGGSVLKGI 1112
GI+L+A+ V L++ VG+ + F + I+ F + VG +R RV +M G ++ G+
Sbjct: 1003 GIKLSAIPAVILILSVGMMLCFNVLISLGF-MTSVG---NRQRRVQLSMQMSLGPLVHGM 1058
Query: 1113 TMTKIIGISVLALTQSKIFQVFYFRMWASLIF--VASLHALIFLPVLLSMIG 1162
+ G++V L+ S V W L+ V + ++L+ P+LLSM+G
Sbjct: 1059 LTS---GVAVFMLSTSPFEFVIRHFCWLLLVVLCVGACNSLLVFPILLSMVG 1107
>CE01720 [T] KOG1935 Membrane protein Patched/PTCH
Length = 1405
Score = 82.8 bits (203), Expect = 3e-15
Identities = 68/272 (25%), Positives = 120/272 (44%), Gaps = 19/272 (6%)
Query: 905 DMSGFPEGDEFMKYFDIWINAPSDPCPLGGKSPYSSAIVYNDSNIITSTFRTGHSPLRSQ 964
D SG D F Y W N + S + + + S T F PL
Sbjct: 1065 DASGIINSDGFYNYLTAWFNVDHMMYYVSQASFFPTPPKWELSKNHTENFIPAAEPLAYS 1124
Query: 965 ED--YINAYKDAQRIVDELND------------LDVYAYSPFYIFFVQYSTIVSLTAKLI 1010
+ Y+ D IVD + D L + + F+ QY + + I
Sbjct: 1125 QIPFYLTGLTDTAVIVDAIKDIRSVCERFTDQGLPNFPQGIAFTFWEQYLFLTGNLMQAI 1184
Query: 1011 TASILLIFFVSWLLLGSAMTSLILSGIVTMIIVDILAMMYFFGIRLNAVSLVNLLICVGL 1070
+ + +F V +LL + +L++ I+ ++ ++ M GI+LN VS V L+ VG+
Sbjct: 1185 SIITISVFCVISVLLFNPWAALMVVCILGIMTCELAGFMGLVGIKLNPVSAVTLITAVGI 1244
Query: 1071 AVEFCIHITRAFTIVPVGVKKDRNSRVIYAMTTIGGSVLKGITMTKIIGISVLALTQSKI 1130
VEF +H+ +F + +G + R S A+ + V+ G + + ++GI +L ++ +
Sbjct: 1245 GVEFTVHVVVSF-LTALGTRSQRTSS---AVDRVFVPVIHG-SFSTLLGILMLGFSEFEF 1299
Query: 1131 FQVFYFRMWASLIFVASLHALIFLPVLLSMIG 1162
++F + +LI + ++ LI LPVLLS G
Sbjct: 1300 VVKYFFIVMTALICIGIINGLILLPVLLSWFG 1331
Score = 71.6 bits (174), Expect = 7e-12
Identities = 49/165 (29%), Positives = 81/165 (48%), Gaps = 16/165 (9%)
Query: 563 VVSASYLIMFFYASWALKRRTG-----GSRYLLGCAGVLIVFSSVIASSGLLSIFGIKST 617
++ A Y +M YA R S L AGVL+V + +A GL + FGI+
Sbjct: 654 IILAGYALMLAYAIVTQARFDNCLPATESSMGLALAGVLVVTFASVAGLGLATWFGIEFN 713
Query: 618 LILAEVIPFLILAIGIDNIFLITHEFDRV----NSHYSSSTIQEKIVLSIGKISPSILFS 673
+++PFL L IG+DN+F++ H + V H + + + +SI S + + S
Sbjct: 714 AATTQIVPFLTLGIGVDNMFMLLHNYRDVVKLAGGHAEMAILMRETGMSILCTSINNILS 773
Query: 674 FLCQGGCFLLATMVEMPAVRNFAICAAVALCFNVVLQLTSYVCIL 718
FL T++ +PA+R+F +++ L FN + LT Y I+
Sbjct: 774 -------FLTGTLLPIPALRSFCAQSSILLTFNFIAILTIYPAII 811
>CE21403 [R] KOG1934 Predicted membrane protein (patched superfamily)
Length = 936
Score = 77.4 bits (189), Expect = 1e-13
Identities = 51/201 (25%), Positives = 101/201 (49%), Gaps = 5/201 (2%)
Query: 961 LRSQEDYINAYKDAQRIVDELNDLDVYAYSPFYIFFVQYSTIVSLTAKLITASILLIFFV 1020
+ + E+ N + +++ + + + YSP + +Y + T + I SI ++ V
Sbjct: 718 VETDEEMFNCARTMRKLSQKHANYSIITYSPLWNIADEYDIMWPQTMQDIYISIAVMVPV 777
Query: 1021 SWLLLGSAMTSLILSGIVTMIIVDILAMMYFFGIRLNAVSLVNLLICVGLAVEFCIHITR 1080
+ L + + S+I+ + I ++ M F G+ L+A S++ + + VG +V+F H++
Sbjct: 778 ALLFIPQPLCSVIIGLNIASIAFGVIGTMSFLGVSLDATSMITVAMSVGFSVDFAAHVSY 837
Query: 1081 AFTI---VPVGVKKDRNSRVIYAMTTIGGSVLKGITMTKIIGISVLALTQSKIFQVFYFR 1137
A+ + K SR + + TIG V + +++ ++G+S L L S + Q FR
Sbjct: 838 AYMTESGAQIPGKSAIYSRFCHTLGTIGWPVTQA-SVSVLLGVSSLYLVDSYVVQT-CFR 895
Query: 1138 MWASLIFVASLHALIFLPVLL 1158
+I + HAL+FLP+LL
Sbjct: 896 TVVLVILFGTTHALVFLPLLL 916
Score = 71.6 bits (174), Expect = 7e-12
Identities = 69/250 (27%), Positives = 113/250 (44%), Gaps = 48/250 (19%)
Query: 510 VTLLLSNHTESAKLW----EEKLEQYLLSLSIPDGLRISFNT------------------ 547
V+L H E+A W + K E++ LS DGL +
Sbjct: 216 VSLDYDGHVENASAWLILYQLKNEKWQLSRDFEDGLAEKIQSGEAPSELLNLYYFHSATF 275
Query: 548 EMSLEKELNSSSDIIVVSASYLIMFFYAS------WALKRRTGGSRY----------LLG 591
+ LEKE + ++ S LI+F + K G ++Y LLG
Sbjct: 276 DQELEKENRRLTPKFSITFSVLIIFAIMTTFTIKFMKFKTENGINQYPVIDWVLSKPLLG 335
Query: 592 CAGVLIVFSSVIASSGLLSIFGIKSTLILAEVIPFLILAIGIDNIFLIT---HEFDRVNS 648
GVL+ ++I+S+GLL +F + + + + V+PFL L IGID+ FL+ HE DR N
Sbjct: 336 ICGVLVTMCAIISSTGLLMLFNV-TFVDMCTVMPFLSLTIGIDDTFLMLAAWHETDR-NL 393
Query: 649 HYSSSTIQEKIVLSIGKISPSILFSFLCQGGCFLLATMVEMPAVRNFAICAAVALCFNVV 708
Y +++I ++ + SI + L FL+ ++ +PAV F ++ A+ F +
Sbjct: 394 PY-----EKRIEKAMRHAAVSISITSLTDALAFLIGSIAPLPAVIYFCYYSSAAILFIFL 448
Query: 709 LQLTSYVCIL 718
LT +V +L
Sbjct: 449 YVLTMFVAVL 458
>CE21608 [R] KOG1934 Predicted membrane protein (patched superfamily)
Length = 800
Score = 75.9 bits (185), Expect = 4e-13
Identities = 51/208 (24%), Positives = 102/208 (48%), Gaps = 5/208 (2%)
Query: 954 FRTGHSPLRSQEDYINAYKDAQRIVDELNDLDVYAYSPFYIFFVQYSTIVSLTAKLITAS 1013
F TG S D + ++ + + E L++ Y F ++ Q TIV +T + +
Sbjct: 536 FSTGFHDAVSWSDRLALLENWREMASEYQHLNLTIYEDFSMYSDQLLTIVPVTQSTVFCA 595
Query: 1014 ILLIFFVSWLLLGSAMTSLILSGIVTMIIVDILAMMYFFGIRLNAVSLVNLLICVGLAVE 1073
++ + + L S +T + + V I + + + + I L+ +S+ LL+ +G +V+
Sbjct: 596 LICMIMILTLFTPSPVTIVTSTAAVLSINLGVFGCLVYMNIDLDPISMTTLLMAIGFSVD 655
Query: 1074 FCIHITRAFTIVPVGVKKDRNSRVIYAMTTIGGSVLKGITMTKIIGISVLALTQSKIFQV 1133
F HIT + G + +R+ +A+ I + + T T ++ I+VLAL + + QV
Sbjct: 656 FVAHITWHYY---KGDFHSKRARIRHALAGIAWPMFQAGTST-MLAITVLALVHAYMVQV 711
Query: 1134 FYFRMWASLIFVASLHALIFLPVLLSMI 1161
F ++ +IF+ H L+ LP++ S +
Sbjct: 712 F-VKVVVLVIFLGMFHGLVVLPIVFSAL 738
Score = 74.7 bits (182), Expect = 8e-13
Identities = 64/268 (23%), Positives = 123/268 (45%), Gaps = 18/268 (6%)
Query: 519 ESAKLWEEKLEQYLLSLSIPDGLRISFNTEMSLEKELNSSSDIIV--VSASYLIMF-FYA 575
E K WE+KL Y LS +R+ +E + +E+ + + + + ++LI+ F
Sbjct: 125 EIMKEWEQKLFAYTLSTENDPLIRVYVTSEGLVSEEVRRTGILAMPLMGVTFLIILAFTI 184
Query: 576 SWALKRRTGGSRYLLGCAGVLIVFSSVIASSGLLSIFGIKSTLILAEVIPFLILAIGIDN 635
LKR S+ GV+ S+ AS G L G + L + V+PFLIL+IG+D+
Sbjct: 185 LTTLKRDPVKSKPFEAFLGVICPILSLCASFGHLFWMGFEY-LPIVTVVPFLILSIGVDD 243
Query: 636 IFLITHEFDRVNSHYSSSTIQEKIVLSIGKISPSILFSFLCQGGCFLLATMVEMPAVRNF 695
+F+ H + R +S +++++ ++ PSI + L F + PA+ F
Sbjct: 244 VFIFIHAWHRTPYKHS---VRDRMAETLADAGPSISITSLTNLLSFAIGIFTPTPAIYTF 300
Query: 696 AICAAVALCFNVVLQLTSYVCIL-----------HFYEKYYDAANVEELTDDNEEEGVLN 744
+ + A+ ++ + Q+ + +L + Y + D EE T ++E +++
Sbjct: 301 CVFISTAVIYDYIYQIFFFSAVLVLSGEREEQRKNAYLWWKDVPLPEEPTGKQKKETIVS 360
Query: 745 RTFLSLLDKKRKVLGVFFSWFIISLVFL 772
R +LD + +S F+I + +
Sbjct: 361 RVLGKVLDFWVDFIMAKWSKFLIGAIMI 388
>CE01915 [T] KOG1935 Membrane protein Patched/PTCH
Length = 714
Score = 73.2 bits (178), Expect = 2e-12
Identities = 56/224 (25%), Positives = 108/224 (48%), Gaps = 17/224 (7%)
Query: 505 SNAFVVTLLLSNHTESAKLWEEKLEQYLLSLSIPDGLRISFNTEMSLEKELNS------S 558
++A L+++ + +++ LE+ L +LS+ + I + L NS S
Sbjct: 98 ADALQFVFLVASPADVFLRFKQSLEETLETLSLYEEHCIHLHRHPLLICSRNSVNSTIPS 157
Query: 559 SDIIVVSASYLIMFFYASWALKRRTGGSRYLLGCAGVLIVFSSVIASSGLLSIFGIKSTL 618
S + ++S ++++ R ++ AGVL+V + +A GL + FGI+
Sbjct: 158 SLLDMLSCWHMLLLLILDLTTAFRLQNHQWGFALAGVLVVTFASVAGIGLATWFGIEFNA 217
Query: 619 ILAEVIPFLILAIGIDNIFLITHEFDRV----NSHYSSSTIQEKIVLSIGKISPSILFSF 674
+++PFL L IG+DN+F++ H + V H + + + +SI S + + S
Sbjct: 218 ATTQIVPFLTLGIGVDNMFMLLHNYRDVVKLAGGHAEMAILMRETGMSILCTSINNILS- 276
Query: 675 LCQGGCFLLATMVEMPAVRNFAICAAVALCFNVVLQLTSYVCIL 718
FL T++ +PA+R+F +++ L FN + LT Y I+
Sbjct: 277 ------FLTGTLLPIPALRSFCAQSSILLTFNFIAILTIYPAII 314
Score = 57.0 bits (136), Expect = 2e-07
Identities = 44/161 (27%), Positives = 78/161 (48%), Gaps = 10/161 (6%)
Query: 968 INAYKDAQRIVDELND--LDVYAYSPFYIFFVQYSTIVSLTAKLITASILLIFFVSWLLL 1025
++A KD + + + D L + + F+ QY + + I+ + +F V +LL
Sbjct: 558 VDAIKDIRSVCERFTDQGLPNFPQGIAFTFWEQYLFLTGNLMQAISIITISVFCVISVLL 617
Query: 1026 GSAMTSLILSGIVTMIIVDILAMMYFFGIRLNAVSLVNLLICVGLAVEFCIHITRAFTIV 1085
+ +L++ I+ ++ ++ M GI+LN VS V L+ VG+ VEF +H+ +F +
Sbjct: 618 FNPWAALMVVCILGIMTCELAGFMGLVGIKLNPVSAVTLITAVGIGVEFTVHVVVSF-LT 676
Query: 1086 PVGVKKDRNS----RVIYAMTTIGGSVLKGITMTKIIGISV 1122
+G + R S RV + S L GI M +G SV
Sbjct: 677 ALGTRSQRTSSAVDRVFVPVIHGSFSTLLGILM---LGFSV 714
>Hs17462432 [I] KOG1933 Cholesterol transport protein (Niemann-Pick C disease
protein)
Length = 1278
Score = 71.2 bits (173), Expect = 9e-12
Identities = 53/213 (24%), Positives = 107/213 (49%), Gaps = 6/213 (2%)
Query: 507 AFVVTLLLSNHTESAKLWEEKLEQYLLSLSIPDGLRISFNTEMSLEKELNSSSDIIVVSA 566
++ +TL+ H + L + LL S LR + ++E+ + ++I +
Sbjct: 233 SYTITLVFQ-HYHAKFLGSLRARLMLLHPSPNCSLRAESLVHVHFKEEIGVA-ELIPLVT 290
Query: 567 SYLIMFFYASWALKR-RTGGSRYLLGCAGVLIVFSSVIASSGLLSIFGIKSTLILAEVIP 625
+Y+I+F Y ++ ++ S++ L A V+ V SS++ S GL ++FG+ TL E+ P
Sbjct: 291 TYIILFAYIYFSTRKIDMVKSKWGLALAAVVTVLSSLLMSVGLCTLFGLTPTLNGGEIFP 350
Query: 626 FLILAIGIDNIFLITHEFDRVNSHYSSSTIQEKIVLSIGKISPSILFSFLCQGGCFLLAT 685
+L++ IG++N+ ++T V S ++ +I + S SI+ + + G L+
Sbjct: 351 YLVVVIGLENVLVLTKS---VVSTPVDLEVKLRIAQGLSSESWSIMKNMATELGIILIGY 407
Query: 686 MVEMPAVRNFAICAAVALCFNVVLQLTSYVCIL 718
+PA++ F + A V L + LQ+ + +L
Sbjct: 408 FTLVPAIQEFCLFAVVGLVSDFFLQMLFFTTVL 440
>CE13900 [R] KOG1934 Predicted membrane protein (patched superfamily)
Length = 881
Score = 67.4 bits (163), Expect = 1e-10
Identities = 47/204 (23%), Positives = 97/204 (47%), Gaps = 9/204 (4%)
Query: 524 WEEKLEQYLLSLSIPDGLRISFNTEMSLEKELNSSSDIIV----VSASYLIMFFYASWAL 579
WE L Y+ + P L ++ N++ + +E+ ++ V S + +++F +A+ +
Sbjct: 146 WETSLFDYVENFDHPF-LNMTVNSDAMIAREVRTNGMTCVPFFSFSVAAVVIFIFATNSR 204
Query: 580 KRRTGGSRYLLGCAGVLIVFSSVIASSGLLSIFGIKSTLILAEVIPFLILAIGIDNIFLI 639
+ ++ G+ + + G L +FG I V+PFLI+ +G D++F+I
Sbjct: 205 EHFVFSHNVVMAILGIAGPLMATGTAFGFLFLFGFPFNSITL-VMPFLIIGVGCDDVFII 263
Query: 640 THEFDRVNSHYSSSTIQEKIVLSIGKISPSILFSFLCQGGCFLLATMVEMPAVRNFAICA 699
H + + S +++++I ++ + PSI + F + PA+ F +
Sbjct: 264 IHAMRKTDK---SESLEDRIAETMEEAGPSITVTSATNCLSFAIGIATPTPAISLFCLYT 320
Query: 700 AVALCFNVVLQLTSYVCILHFYEK 723
VA+ + V QLT +V +L + EK
Sbjct: 321 CVAVAVDFVYQLTFFVAVLVYEEK 344
>CE29096 [T] KOG1935 Membrane protein Patched/PTCH
Length = 1391
Score = 66.6 bits (161), Expect = 2e-10
Identities = 41/157 (26%), Positives = 79/157 (50%), Gaps = 9/157 (5%)
Query: 557 SSSDIIVVSASYLIMFFYASWALKRRTGG-----SRYLLGCAGVLIVFSSVIASSGLLSI 611
S + I++ Y++M YA++ R G S L GV++V S I G +
Sbjct: 645 SQFNYIIIVIGYILMVIYAAFTQGRFQGWWLAVQSNVALAICGVILVTISSICGLGFATH 704
Query: 612 FGIKSTLILAEVIPFLILAIGIDNIFLITHEFDRVNSHYSSSTIQEKIVLSIGKISPSIL 671
GI +V+PFL L +GID++FL+ H +D + + + + +I + + + S++
Sbjct: 705 LGINFNAATTQVVPFLSLGLGIDDMFLLLHNYDEIINICN----KNEIGVLLKETGMSVM 760
Query: 672 FSFLCQGGCFLLATMVEMPAVRNFAICAAVALCFNVV 708
+ + F+ ++ +PA+R+F A+ L FN++
Sbjct: 761 LTSINNILAFISGYVLPIPALRSFCSQTAILLAFNLI 797
Score = 62.4 bits (150), Expect = 4e-09
Identities = 43/172 (25%), Positives = 81/172 (47%), Gaps = 5/172 (2%)
Query: 993 YIFFVQYSTIVSLTAKLITASILLIFFVSWLLLGSAMTSLILSGIVTMIIVDILAMMYFF 1052
+ F+ QY T+ + I L +F V +L+ + + ++ IV + +++ M
Sbjct: 1155 FTFWEQYLTLRWNLFQAICIIALAVFCVISILMFNPWAATLIMCIVVITTIELGGFMGLM 1214
Query: 1053 GIRLNAVSLVNLLICVGLAVEFCIHITRAFTIVPVGVKKDRNSRVIYAMTTIGGSVLKGI 1112
GI++N +S V L+ VG+ VEF H+ AF + +G R + M V G
Sbjct: 1215 GIKMNPISAVTLICAVGIGVEFTAHVELAF-LTALGTIDQRLESCLQHMFV---PVYHGA 1270
Query: 1113 TMTKIIGISVLALTQSKIFQVFYFRMWASLIFVASLHALIFLPVLLSMIGGK 1164
T +G+ +L ++ ++F L+ + + L LPV+L+++G K
Sbjct: 1271 IST-FLGVVMLVFSEFDFVVTYFFYTMTLLVALGVFNGLCVLPVILTLVGPK 1321
>CE25194 [T] KOG1935 Membrane protein Patched/PTCH
Length = 1388
Score = 66.6 bits (161), Expect = 2e-10
Identities = 41/157 (26%), Positives = 79/157 (50%), Gaps = 9/157 (5%)
Query: 557 SSSDIIVVSASYLIMFFYASWALKRRTGG-----SRYLLGCAGVLIVFSSVIASSGLLSI 611
S + I++ Y++M YA++ R G S L GV++V S I G +
Sbjct: 645 SQFNYIIIVIGYILMVIYAAFTQGRFQGWWLAVQSNVALAICGVILVTISSICGLGFATH 704
Query: 612 FGIKSTLILAEVIPFLILAIGIDNIFLITHEFDRVNSHYSSSTIQEKIVLSIGKISPSIL 671
GI +V+PFL L +GID++FL+ H +D + + + + +I + + + S++
Sbjct: 705 LGINFNAATTQVVPFLSLGLGIDDMFLLLHNYDEIINICN----KNEIGVLLKETGMSVM 760
Query: 672 FSFLCQGGCFLLATMVEMPAVRNFAICAAVALCFNVV 708
+ + F+ ++ +PA+R+F A+ L FN++
Sbjct: 761 LTSINNILAFISGYVLPIPALRSFCSQTAILLAFNLI 797
Score = 62.4 bits (150), Expect = 4e-09
Identities = 43/172 (25%), Positives = 81/172 (47%), Gaps = 5/172 (2%)
Query: 993 YIFFVQYSTIVSLTAKLITASILLIFFVSWLLLGSAMTSLILSGIVTMIIVDILAMMYFF 1052
+ F+ QY T+ + I L +F V +L+ + + ++ IV + +++ M
Sbjct: 1152 FTFWEQYLTLRWNLFQAICIIALAVFCVISILMFNPWAATLIMCIVVITTIELGGFMGLM 1211
Query: 1053 GIRLNAVSLVNLLICVGLAVEFCIHITRAFTIVPVGVKKDRNSRVIYAMTTIGGSVLKGI 1112
GI++N +S V L+ VG+ VEF H+ AF + +G R + M V G
Sbjct: 1212 GIKMNPISAVTLICAVGIGVEFTAHVELAF-LTALGTIDQRLESCLQHMFV---PVYHGA 1267
Query: 1113 TMTKIIGISVLALTQSKIFQVFYFRMWASLIFVASLHALIFLPVLLSMIGGK 1164
T +G+ +L ++ ++F L+ + + L LPV+L+++G K
Sbjct: 1268 IST-FLGVVMLVFSEFDFVVTYFFYTMTLLVALGVFNGLCVLPVILTLVGPK 1318
>CE24422 [R] KOG1934 Predicted membrane protein (patched superfamily)
Length = 860
Score = 63.9 bits (154), Expect = 1e-09
Identities = 85/385 (22%), Positives = 158/385 (40%), Gaps = 30/385 (7%)
Query: 387 FDANFGPFYRTEQVFIVN-DTGPVLSYENLKWWFETENLITENLLS---TENISYQDLCF 442
F+ G + Q+ + + G +L+ E L + + +N+ + T +I+Y++LC
Sbjct: 67 FEYASGSHHHRMQILVSKKNRGNILTNEALGEVSQAHKFVADNITAFDGTRHIAYKNLCG 126
Query: 443 RPTEDSTCVIESVTQYFQGILPD--ESSWKQQLESCTDSPVNCLPSFQQ-PLKTNVLFSD 499
DS +V + Q L D SS+K + + LK +
Sbjct: 127 VYCNDSNA---AVLAFLQATLNDTSRSSFKLTFPNAEALQKKIFVGYSLGDLKIEKGYVT 183
Query: 500 ENVFESNAFVVTLLLSNHTESAKLWEEKLEQYLLSLS-IPDGLRISFNTEMSLEKELNSS 558
E ++V + N A +E K+ + S+S + ++ S +S +EL
Sbjct: 184 EAKMVVLHYMVDTSIPNGRALATDFENKVRAFFASISDLSHHIKYSV---LSRTRELEEQ 240
Query: 559 SDIIVVSASYL------IMFFYASWALKRRTGGSRYLLGCAGVLIVFSSVIASSGLLSIF 612
I + S +L + F ++ S++ GVL ++ ++GLL
Sbjct: 241 RAITITSLPFLGLTIVVLTCFMLVTLVRFPLYTSQHWQSIVGVLSPGMALWTTTGLLWGI 300
Query: 613 GIKSTLILAEVIPFLILAIGIDNIFLITHEFDRVNSHYSSSTIQEKIVLSIGKISPSILF 672
G + IL V+PFL++ IGID+ FLI + + +++ ++ S+ S+
Sbjct: 301 GYPFSNILT-VVPFLVVTIGIDDAFLILAGWRQSTK---GESLEVRLGQSVAISGASVTV 356
Query: 673 SFLCQGGCFLLATMVEMPAVRNFAICAAVALCFNVVLQLTSYVCILH-FYEKYYD----- 726
+ + CF MP V+ F + VAL + + Q+T + ++ F K D
Sbjct: 357 TSVTDVACFATGLFSNMPVVQLFCLYTTVALAIDFIYQMTFFTALVGIFVRKQVDIEKEL 416
Query: 727 AANVEELTDDNEEEGVLNRTFLSLL 751
N ++ EEEG + + SLL
Sbjct: 417 VKNEPKIEKTKEEEGASSSSLASLL 441
>CE29236 [R] KOG1934 Predicted membrane protein (patched superfamily)
Length = 968
Score = 62.8 bits (151), Expect = 3e-09
Identities = 36/138 (26%), Positives = 70/138 (50%), Gaps = 2/138 (1%)
Query: 587 RYLLGCAGVLIVFSSVIASSGLLSIFGIKSTLILAEVIPFLILAIGIDNIFLITHEFDRV 646
+ L+ VL ++ ++ G++SI G+++ + V+PFL++ IG+D+ FL+ H + +
Sbjct: 356 KLLISLGAVLCPILAITSTYGIVSILGMRTNSFML-VMPFLVMGIGVDSCFLMIHSWQKE 414
Query: 647 NSHYSSSTIQEKIVLSIGKISPSILFSFLCQGGCFLLATMVEMPAVRNFAICAAVALCFN 706
+S T ++ + + PSI + L F + + P R F I +++AL
Sbjct: 415 RRAQASGT-GNRLGMVYESVGPSITITSLTDFLSFAIGALAPTPETRLFCIASSIALALT 473
Query: 707 VVLQLTSYVCILHFYEKY 724
+LQL + IL +Y
Sbjct: 474 YILQLVLFGPILAVATRY 491
>CE02557 [R] KOG1934 Predicted membrane protein (patched superfamily)
Length = 1037
Score = 60.8 bits (146), Expect = 1e-08
Identities = 51/201 (25%), Positives = 94/201 (46%), Gaps = 8/201 (3%)
Query: 524 WEEKLEQYLLSLSIPDGLRISFNTEMSLEKELNSSSDIIV---VSASYLIMFFYASWALK 580
+ +KL +Y S+S L+ + + +++ E+ V A+ L+ F S
Sbjct: 381 YRQKLNEYWESISENIDLQFIPHNDKAMDDEMLEIIKTTVPFAFPATILLTIFVLSANYS 440
Query: 581 RRTGGSRYLLGCAGVLIVFSSVIASSGLLSIFGIKSTLILAEVIPFLILAIGIDNIFLIT 640
S+ + C GV V ++I + G+ FG K + + +PFL+LA+G+D+ FL+
Sbjct: 441 SDRTKSKPIEMCVGVWCVIFALIITFGVFFFFGAKFNPVTS-TMPFLVLAVGVDDDFLMM 499
Query: 641 HEFDRVNSHYSSSTIQEKIVLSIG-KISPSILFSFLCQGGCFLLATMVEMPAVRNFAICA 699
+ + +S + ++ G I+ + +F C FL M PAV +F I
Sbjct: 500 AAWRECDRKHSPAIRLGFVMADAGASITVTSFTNFFC---FFLGWFMCSTPAVADFCIIT 556
Query: 700 AVALCFNVVLQLTSYVCILHF 720
A + F+ ++Q+T Y IL +
Sbjct: 557 AAGVFFDYLMQITFYAAILKY 577
Score = 57.4 bits (137), Expect = 1e-07
Identities = 39/186 (20%), Positives = 94/186 (49%), Gaps = 6/186 (3%)
Query: 977 IVDELNDLDVYAYSPFYIFFV-QYSTIVSLTAKLITASILLIFFVSWLLLGSAMTSLILS 1035
I+ E + D++ F F + Q TI + + I +++ ++ +S+ L A + +++
Sbjct: 833 ILKEFPEFDMFLSGIFSPFLIDQRHTIAPSSMQTIGSALAMMALISFFFLPDAQSVFLMT 892
Query: 1036 GIVTMIIVDILAMMYFFGIRLNAVSLVNLLICVGLAVEFCIHITRAFTIVPVGVKKDRNS 1095
+ I + + + G L++VS+ +++ +GLAV++ +HI + K
Sbjct: 893 FSLLSISMGVCGGLALLGSDLDSVSMGCIVMAIGLAVDYSVHICYRY---HRSEYKTAQE 949
Query: 1096 RVIYAMTTIGGSVLKGITMTKIIGISVLALTQSKIFQVFYFRMWASLIFVASLHALIFLP 1155
+V + ++G V + + T ++G+++ + + +VF+ ++ I + HAL++LP
Sbjct: 950 KVADTLASVGWPVTQAVCST-LVGLAITVFVPAYLVRVFFQTVYLVNI-IGLFHALVWLP 1007
Query: 1156 VLLSMI 1161
L+S +
Sbjct: 1008 QLISAL 1013
>CE01000 [R] KOG1934 Predicted membrane protein (patched superfamily)
Length = 890
Score = 58.5 bits (140), Expect = 6e-08
Identities = 60/284 (21%), Positives = 119/284 (41%), Gaps = 33/284 (11%)
Query: 518 TESAKLWEEKLEQYLLSLSIPDGLRISFNTEMSLEKELN----SSSDIIVVSASYLIMF- 572
T++ K WE ++ + D + + ++ +E E+ S ++V + +F
Sbjct: 218 TKTVKQWELRVRDHFAKEYSSDLIIVDVMSQTVVESEIVRAGLSLQPFLIVGFVIMSIFC 277
Query: 573 -----FYASWALKRRTGGSRYLLGCAGVLIVFSSVIASSGLLSIFGIKSTLILAEVIPFL 627
F A + ++ ++ L + F + + G+L G+ + I+ + PFL
Sbjct: 278 TVTTMFSAVYLYSQKATFNKVALSIIACINPFMACGTAMGILFFCGVTFSPIMC-ITPFL 336
Query: 628 ILAIGIDNIFLITHEFDRVNSHYSSSTIQEKIVLSIGKI----SPSILFSFLCQGGCFLL 683
+LAI +D+ FL+ H ++R+ S ++ + +G++ P+I S F +
Sbjct: 337 VLAISVDDSFLMLHAWNRLESWRTAPLDKPMREHMMGEVLVETGPAISISAFTNMLAFTI 396
Query: 684 ATMVEMPAVRNFAICAAVALCFNVVLQLTSYVCILHFYEKYYDAANVEELTDDNEEEGVL 743
+ P +R F A A+ ++ Q T Y + L D EGV
Sbjct: 397 GAITSPPEIRIFCFGNAAAIFMDMFYQATFYTACMTL------------LGDTKNSEGVS 444
Query: 744 NRTFLSLLDKKRKVLGVFFSWFI--ISLVFLPSIKFGLDQTMAV 785
+T + ++ V+G F W++ IS +F + FG+ AV
Sbjct: 445 EKT-KRIQERMGNVVGRFLKWYVNAISNIF---VSFGIVLVWAV 484
>Hs20555011 [R] KOG1934 Predicted membrane protein (patched superfamily)
Length = 510
Score = 54.7 bits (130), Expect = 8e-07
Identities = 45/218 (20%), Positives = 100/218 (45%), Gaps = 11/218 (5%)
Query: 945 NDSNIITSTFRTGHSPLRSQEDYINAYKDAQRIVDELNDLDVYAYSPFYIFFVQYSTIVS 1004
++SNII S R ++ I + R + + ++P ++F YS V+
Sbjct: 263 DESNIIASRLYLVARTSRDKQKEITEVLEKLRPLSLSKSIRFIVFNPSFVFMDHYSLSVT 322
Query: 1005 LTAKLITASILLIFFVSWLLLGSAMTSLILSGIVTMIIVDILAMMYFFGIRLNAVSLVNL 1064
+ + +LL+ +++ L+ + + L VT I + +L +M + + ++ +S++ L
Sbjct: 323 VPVLIAGFGVLLVLILTFFLVIHPLGNFWLILSVTSIELGVLGLMTLWNVDMDCISILCL 382
Query: 1065 LICVGLAVEFCIHITRAFTIVPVGVKKDRNSRVIYAMTTIGGSVLKGITMTKIIGISVLA 1124
+ + A++ C + FT V + + R + ++ G ++L+ +T + +IG+ L
Sbjct: 383 IYTLNFAIDHCAPL--LFTFV-LATEHTRTQCIKSSLQDHGTAILQNVT-SFLIGLVPLL 438
Query: 1125 LTQSKIFQVFYFRMWASLIFVAS---LHALIFLPVLLS 1159
S + F ++ L+ LH + LPV L+
Sbjct: 439 FVPSNL----TFTLFKCLLLTGGCTLLHCFVILPVFLT 472
>CE01601 [R] KOG1934 Predicted membrane protein (patched superfamily)
Length = 690
Score = 54.7 bits (130), Expect = 8e-07
Identities = 60/264 (22%), Positives = 110/264 (40%), Gaps = 31/264 (11%)
Query: 623 VIPFLILAIGIDNIFLITHEFDR-VNSHYSSSTIQEKIVLSIGKISPSILFSFLCQGGCF 681
+ PFLIL IG+D+ FL+ + + R S+ + ++ I +ISPS+ + L F
Sbjct: 164 ITPFLILGIGVDDAFLLLNCWRREEGKDKSAKQAENQLARVIREISPSMAITSLTNTMAF 223
Query: 682 LLATMVEMPAVRNFAICAAVALCFNVVLQLTSYV-CILHFYEKYYDAANVEELTDDNEEE 740
+ + P + +F + A+A+ + +L+ +V C++ FY+K + +E NE+
Sbjct: 224 GVGFLAPTPQMSSFCLGTALAIVLDFLLEFLIFVPCMVLFYKKKPEIIAIENEEFANEKT 283
Query: 741 GVLNRT------------FLSLL---DKKRKVLGVFFSWFIISLVFLPSIKFGLDQTMAV 785
+ T F +LL + V+ ++FS F S + ++ D +
Sbjct: 284 EKRSETSTGKYSRINWKCFTNLLLSVPGRVLVIILYFSIFTASYFGVAKMEKTFDPSKTF 343
Query: 786 PQNSYLVNYFQDVYEYLNVGPPVYFVVKNLDLRIKSAQKKICGKFTECDDYSLGNVLELE 845
P +S LV+ P+ F+ DL+ + D + +L
Sbjct: 344 PSDSKLVDSLASFTSIQVEYSPLNFLSSVPDLK------------NDTDVANFNEMLHKL 391
Query: 846 RLRSSIVEPLA--NWYDDYMMFLN 867
R + N Y DY+ FLN
Sbjct: 392 EFREECYGDVGSHNMYRDYVQFLN 415
>CE17902 [R] KOG1934 Predicted membrane protein (patched superfamily)
Length = 820
Score = 53.9 bits (128), Expect = 1e-06
Identities = 50/230 (21%), Positives = 95/230 (40%), Gaps = 7/230 (3%)
Query: 588 YLLGCAGVLIVFSSVIASSGLLSIFGIKSTLILAEVIPFLILAIGIDNIFLITHEFDRVN 647
+ L +L ++ +AS G + G S I V PFL+L IG+D+ F++ H R
Sbjct: 269 FYLVATSLLTPMAATVASFGAICWMGFPSFSIQC-VTPFLVLGIGVDDAFILLH---RWK 324
Query: 648 SHYSSSTIQEKIVLSIGKISPSILFSFLCQGGCFLLATMVEMPAVRNFAICAAVALCFNV 707
H + + ++ I + PSI + L F + + P + F + A++AL +
Sbjct: 325 HHIAITDTPRRLEQVIVDVGPSITITSLTNIIAFGIGFLTPTPQMSLFCLTASLALLLDY 384
Query: 708 VLQLTSYVCILHFYE--KYYDAANVEELTDDNEEEGVLN-RTFLSLLDKKRKVLGVFFSW 764
+ T I+ Y AN E + + +F+ + + + V
Sbjct: 385 IFTYTILAPIVFLCNDPDYKSIANETEPKISRADTWLSKYSSFVCSVKGRVACIMVLLGM 444
Query: 765 FIISLVFLPSIKFGLDQTMAVPQNSYLVNYFQDVYEYLNVGPPVYFVVKN 814
+ ++ + ++K + A P NS LV+ ++ N P+ +V N
Sbjct: 445 YALTTYGVVTMKTTFEPAKAFPSNSKLVDSLSNIKPVFNRYFPITVIVNN 494
>CE15305 [R] KOG1934 Predicted membrane protein (patched superfamily)
Length = 983
Score = 52.4 bits (124), Expect = 4e-06
Identities = 33/141 (23%), Positives = 68/141 (47%), Gaps = 9/141 (6%)
Query: 589 LLGCAGVLIVFSSVIASSGLLSIFGIKSTLILAEVIPFLILAIGIDNIFLITHEFDRVNS 648
++ C L+ ++ +A L+ + G++ IL VIPFL+L+IG+D+ +L+ HE+ RV
Sbjct: 350 IMACLTPLLACATALA---LMFLCGVRFASILC-VIPFLVLSIGVDSSYLMIHEWQRVTK 405
Query: 649 HY-----SSSTIQEKIVLSIGKISPSILFSFLCQGGCFLLATMVEMPAVRNFAICAAVAL 703
H ++ ++ + ++ P+IL S L + + P + +++
Sbjct: 406 HMRETPRKKDSVGHRMSEVMAEVGPAILISCLTNMFADAVGSFTSSPEITLLCTGNMLSM 465
Query: 704 CFNVVLQLTSYVCILHFYEKY 724
F + Q+T Y ++ Y
Sbjct: 466 WFAFIYQMTFYAGLMSIVGGY 486
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.323 0.139 0.422
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 70,827,121
Number of Sequences: 60738
Number of extensions: 3174464
Number of successful extensions: 7954
Number of sequences better than 1.0e-05: 37
Number of HSP's better than 0.0 without gapping: 24
Number of HSP's successfully gapped in prelim test: 13
Number of HSP's that attempted gapping in prelim test: 7750
Number of HSP's gapped (non-prelim): 90
length of query: 1177
length of database: 30,389,216
effective HSP length: 118
effective length of query: 1059
effective length of database: 23,222,132
effective search space: 24592237788
effective search space used: 24592237788
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)