ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactVI7319 good OT KOG3986 Posttranslational modification, protein turnover, chaperones Protein phosphatase, regulatory subunit PPP1R3C/D
r_klactVI7319 good OT KOG3986 Signal transduction mechanisms Protein phosphatase, regulatory subunit PPP1R3C/D
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactVI7319 2549457 2550950 498
(498 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YER054c [OT] KOG3986 Protein phosphatase regulatory subunit PPP1... 100 4e-21
YIL045w [OT] KOG3986 Protein phosphatase regulatory subunit PPP1... 93 1e-18
Hs4885559 [OT] KOG3986 Protein phosphatase regulatory subunit PP... 78 3e-14
7294385 [OT] KOG3986 Protein phosphatase regulatory subunit PPP1... 72 2e-12
CE28737 [OT] KOG3986 Protein phosphatase regulatory subunit PPP1... 64 5e-10
CE23615 [OT] KOG3986 Protein phosphatase regulatory subunit PPP1... 62 2e-09
CE20615 [OT] KOG3986 Protein phosphatase regulatory subunit PPP1... 62 2e-09
7293805 [OT] KOG3986 Protein phosphatase regulatory subunit PPP1... 59 2e-08
Hs13375815 [OT] KOG3986 Protein phosphatase regulatory subunit P... 55 2e-07
Hs4506011 [OT] KOG3986 Protein phosphatase regulatory subunit PP... 53 9e-07
>YER054c [OT] KOG3986 Protein phosphatase regulatory subunit PPP1R3C/D
Length = 548
Score = 100 bits (250), Expect = 4e-21
Identities = 138/551 (25%), Positives = 215/551 (38%), Gaps = 143/551 (25%)
Query: 16 SSLNFLRKPQRISCQVETTAMNDALKRNTDLNKSKIIVDKSLQDSQHDEHDPVGNELAGR 75
+SL FL KPQR++ + ++RNTDLNK S + ++ +++ +++A
Sbjct: 57 NSLKFLHKPQRVTQMRANRFPEEEVQRNTDLNKRIF----SAGNDENVDNESGWSKIAAA 112
Query: 76 LNEKLNFNKDADPSKKEDWDVETDPLKKEAWESETDPSLSMQDYFPVSKPDVPEVEIXXX 135
N + + S + + +E PL ++ T P S Q +P +K P ++
Sbjct: 113 KNH--TSVESLNGSTRPPFKIELPPLSPKS----TVPK-SFQAEYPEAKS--PGNDMNFE 163
Query: 136 XXXXXXXXXXEPEDRYLDSRKLSAIFNPPSILLTRSKSLPTSP---LEGRVSQEQRPPVF 192
P Y S +L S L RSKSLPT+P V P+
Sbjct: 164 YDEEILIPFAPPV--YKKSGELLK-----SSLKRRSKSLPTTPGIRSGNGVQARDGSPML 216
Query: 193 KRSKSVH---------FAQSEK---------------FEVKYFR-----EDES------- 216
RSKSVH FA+ E F+ K E+E+
Sbjct: 217 IRSKSVHFDQAAPVKYFAEDESPINVNKTEQHDNCLSFKHKPVNLMVDPEEETKMLSSGL 276
Query: 217 -------------------PLFLRNESGEYGTKSGKLRKSRRHR-----------SREAV 246
P + N + GT + KLRKS+R + S+
Sbjct: 277 ETTSIDDDLTTVAPKGFAHPAKISNPNNGKGTNNTKLRKSKRFQNLLKNRTDMPPSKSNK 336
Query: 247 AKVNGXXXXXXMLNMKGSKRSLELVNGNL-ILQAQTPKLLRLDVFGVRKNQFQTFANGIY 305
VNG + + L + N IL + PK L+L++F + F +
Sbjct: 337 KFVNGGGAHEISDRNSKNYHVVGLYSKNFPILSNKNPKSLKLNIFINLSQNKKVFLQELS 396
Query: 306 NSMNTPNSGWSNSLHSNNAPFWKYSHGIXXXXXXXXXXXXXXXXXXXXTTGIPNFDFSSP 365
++ N+ +SNS N IPN S
Sbjct: 397 LYIHRDNNYFSNSSSFYN---------------------------------IPN---SHN 420
Query: 366 FNTNDSFKKEANLGTFICHLQDLRLDTQGHMLIGNVIVRNISYEKRVIVRYTLDSWKSQQ 425
N + K N G ++ G ++V+NI Y+KRV+VRYT DSW++
Sbjct: 421 GNDCNGVAKGYNAGCT-------------RLIAGRILVKNIFYDKRVVVRYTWDSWRTTH 467
Query: 426 DVESVWITNHCNLKSGTGAIDIDVFQFAI-DLGKINTIEHIEMCILYQTREGSSWIDHWD 484
+VE V+I++ + GT ++D+F F I D+ K++ +E CI Y TR ++WD
Sbjct: 468 EVECVYISDGDGILPGT---NMDIFHFIIDDVSKVDPRGKLEFCIHYSTRNDYEREEYWD 524
Query: 485 NNSGQNYKVSV 495
NN+G NYKV V
Sbjct: 525 NNNGNNYKVDV 535
>YIL045w [OT] KOG3986 Protein phosphatase regulatory subunit PPP1R3C/D
Length = 538
Score = 92.8 bits (229), Expect = 1e-18
Identities = 126/527 (23%), Positives = 209/527 (38%), Gaps = 101/527 (19%)
Query: 9 NLQSGKFSSLNFLRKPQRISCQVETTAMNDALKRNTDLNKSKIIVDKSLQDSQHDEHDPV 68
++ + +SL FL KP+R+S D L+RNTD+NK K + H P
Sbjct: 44 HMHPARLNSLEFLHKPRRLSNVKLHRLPQDELQRNTDMNKGMYFNGKQVH-----AHHPF 98
Query: 69 GNELAGRLNEKLNFNKD-ADPSKKEDWDVETDPLKKEAWESETDPSLSMQDYFPVSKPDV 127
+N NFN D SK + + E PL + ++ E++ + P
Sbjct: 99 -------INSGANFNAHHQDVSKLGEEEDEISPLSHDNFQYESEEN---------GNPSP 142
Query: 128 PEVEIXXXXXXXXXXXXXEPEDRYLDSRKLSAIFNPPSILL---TRSKSLPTSPLEGRVS 184
P + E L R S P SI ++SK + ++ R+
Sbjct: 143 PIYK-----------KSGELVKSSLKRRSKSLPITPKSIFNKTGSKSKHVNLDHVDTRLL 191
Query: 185 QEQRPPVFKRSKSVHFAQSEKFEVKYFREDESPLFLRNESGEYGTKSGKLRKSRRHRSRE 244
Q RSKSVHF +K F E+E P+ + + + + K H+
Sbjct: 192 Q--------RSKSVHF--DRVLPIKLFNENEKPIDVGKQMVQQDVLNFK------HKPLT 235
Query: 245 AVAKVNGXXXXXXMLNMKGSKRSLELVNGNLILQAQTPKLLRLDVFGV----RKNQFQTF 300
++ +NG + ++ E + L Q PK + L FG R+N+ + F
Sbjct: 236 RLSALNGGSDSVPIEDLLSENNQNEYGDTWL----QNPKGVFL--FGTNSNNRRNKKKKF 289
Query: 301 A-----NGIYNSMNTPNSGWSNSLHSNNAPFWKYSHGIX------------XXXXXXXXX 343
+ I N N + + + + +HG+
Sbjct: 290 KLSDDDSDIEND-NDSDDAINRLVRQQDKDQAHLAHGLKNLLINDDDDYLETRTNSAKSG 348
Query: 344 XXXXXXXXXXTTGIPNFDFSSPFNTNDSFKKEANLGTFI-------CHLQDLRLDTQGH- 395
G+ N +F +D +K L F+ LQ++ L T H
Sbjct: 349 ANLFIGNSKRIVGLYNKNFPI---LSDRNRKSLKLNIFLNLSRGRPVFLQEITLLTGFHN 405
Query: 396 -MLIGNVIVRNISYEKRVIVRYTLDSWKSQQDVESVWITNHCNLKSGTGAIDIDVFQFAI 454
++IG V V+NI ++K++IVRYT D+W++ + E V+ +N + G+ ++D+F+F+I
Sbjct: 406 MVIIGKVFVKNIYFDKKIIVRYTWDAWRTFHESECVYFSNANGILPGS---NMDIFKFSI 462
Query: 455 D-----LGKINTIEHIEMCILYQT-REGSSWIDHWDNNSGQNYKVSV 495
D K + I +E CI Y T S ++WDNN NYK+ V
Sbjct: 463 DDIHNPNDKDSNISQLEFCIQYLTWGVDRSRKEYWDNNDSANYKIDV 509
>Hs4885559 [OT] KOG3986 Protein phosphatase regulatory subunit PPP1R3C/D
Length = 317
Score = 77.8 bits (190), Expect = 3e-14
Identities = 53/134 (39%), Positives = 72/134 (53%), Gaps = 15/134 (11%)
Query: 361 DFSSPFNTNDSFKKEANLGTFICHLQDLRLDTQGHMLIGNVIVRNISYEKRVIVRYTLDS 420
DF P SF+ F+C L++ L Q + G V V+N+S+EK+V +R T DS
Sbjct: 137 DFPQPSTDYLSFRSHFQKN-FVC-LENCSL--QERTVTGTVKVKNVSFEKKVQIRITFDS 192
Query: 421 WKSQQDVESVWITNHCNLKSGTGAIDIDVFQFAIDLGK-INTIEHIEMCILYQTREGSSW 479
WK+ DV+ V+ +K+ G D D F FAIDL I T + IE CI Y G +
Sbjct: 193 WKNYTDVDCVY------MKNVYGGTDSDTFSFAIDLPPVIPTEQKIEFCISYHA-NGQVF 245
Query: 480 IDHWDNNSGQNYKV 493
WDNN GQNY++
Sbjct: 246 ---WDNNDGQNYRI 256
>7294385 [OT] KOG3986 Protein phosphatase regulatory subunit PPP1R3C/D
Length = 384
Score = 72.0 bits (175), Expect = 2e-12
Identities = 42/136 (30%), Positives = 72/136 (52%), Gaps = 10/136 (7%)
Query: 361 DFSSPFNTNDSFKKEANLGTFICHLQDLRLDTQGHMLIGNVIVRNISYEKRVIVRYTLDS 420
DF P + SF+++ L+++ + + +++G + V+NI ++K +IVR T D
Sbjct: 210 DFKQPASDYLSFRQKIERD--FVSLENVIVKDEESIVVGTIKVKNIDFQKEIIVRVTWDD 267
Query: 421 WKSQQDVESVWITNHCNLKSGTGAIDIDVFQFAIDLGKINTIEHIEMCILYQTREGSSWI 480
WKSQQD+ + + + + D F F I L + + +E CI Y+T E
Sbjct: 268 WKSQQDIFCTYARAYG--PATCAHVVFDTFSFKITLPP--SSKRLEFCICYRTNE----T 319
Query: 481 DHWDNNSGQNYKVSVR 496
++WDNN G+NY +S R
Sbjct: 320 EYWDNNDGKNYTISKR 335
>CE28737 [OT] KOG3986 Protein phosphatase regulatory subunit PPP1R3C/D
Length = 400
Score = 63.9 bits (154), Expect = 5e-10
Identities = 33/108 (30%), Positives = 62/108 (56%), Gaps = 13/108 (12%)
Query: 385 LQDLRLDTQGHMLIGNVIVRNISYEKRVIVRYTLDSWKSQQDVESVWITNHCNLKSGTGA 444
L+++ L+ + + ++G + V NI++EK V VRYT++ W S D +++ + ++
Sbjct: 249 LENVILNNEAYKVMGTIKVGNIAFEKSVFVRYTMNGWISYMDKAAIYQPSTSKIQ----- 303
Query: 445 IDIDVFQFAIDL-GKINTIEHIEMCILYQTREGSSWIDHWDNNSGQNY 491
D F+F +DL + I IE CI ++ ++ ++WD+NSG NY
Sbjct: 304 ---DTFKFDLDLPSSVEKIHQIEFCICFK----ANGTEYWDSNSGTNY 344
>CE23615 [OT] KOG3986 Protein phosphatase regulatory subunit PPP1R3C/D
Length = 295
Score = 62.4 bits (150), Expect = 2e-09
Identities = 34/109 (31%), Positives = 56/109 (51%), Gaps = 10/109 (9%)
Query: 390 LDTQGHMLIGNVIVRNISYEKRVIVRYTLDSWKSQQDVESVWITNHCNLKSGTGAIDIDV 449
L G ++G V + N++++K V+VRYT+D W +Q ++ + + + + DID
Sbjct: 140 LRASGSSIVGQVNLLNVAFDKVVVVRYTIDGWATQDEIVASYSHRLFDTE------DIDA 193
Query: 450 FQFAIDLGKINTIEHIEMCILYQTREGSSWIDHWDNNSGQNYKVSVRVK 498
F F I + + E C+ YQ + + WDNN G NY V+V K
Sbjct: 194 FNFTIAIPVKLSEGKCEFCVQYQV----AGAEFWDNNGGDNYIVNVSTK 238
>CE20615 [OT] KOG3986 Protein phosphatase regulatory subunit PPP1R3C/D
Length = 318
Score = 62.4 bits (150), Expect = 2e-09
Identities = 34/109 (31%), Positives = 56/109 (51%), Gaps = 10/109 (9%)
Query: 390 LDTQGHMLIGNVIVRNISYEKRVIVRYTLDSWKSQQDVESVWITNHCNLKSGTGAIDIDV 449
L G ++G V + N++++K V+VRYT+D W +Q ++ + + + + DID
Sbjct: 163 LRASGSSIVGQVNLLNVAFDKVVVVRYTIDGWATQDEIVASYSHRLFDTE------DIDA 216
Query: 450 FQFAIDLGKINTIEHIEMCILYQTREGSSWIDHWDNNSGQNYKVSVRVK 498
F F I + + E C+ YQ + + WDNN G NY V+V K
Sbjct: 217 FNFTIAIPVKLSEGKCEFCVQYQV----AGAEFWDNNGGDNYIVNVSTK 261
>7293805 [OT] KOG3986 Protein phosphatase regulatory subunit PPP1R3C/D
Length = 681
Score = 58.5 bits (140), Expect = 2e-08
Identities = 31/101 (30%), Positives = 54/101 (52%), Gaps = 11/101 (10%)
Query: 391 DTQGHMLIGNVIVRNISYEKRVIVRYTLDSWKSQQDVESVWITNHCNLKSGTGAIDIDVF 450
D + G+V VRN+ + K V +RY+LD W+S D+++ ++ N C+ S D+F
Sbjct: 540 DNINQTISGSVRVRNLDFHKSVHIRYSLDGWRSYADLQANYVENSCDGFS-------DIF 592
Query: 451 QFAIDLGKINTIEHIEMCILYQTREGSSWIDHWDNNSGQNY 491
F + ++ + +E + +Q + G + WDNN G NY
Sbjct: 593 TFVLFGNSLHVGQRLEFAVRFQCK-GQQF---WDNNYGANY 629
>Hs13375815 [OT] KOG3986 Protein phosphatase regulatory subunit PPP1R3C/D
Length = 285
Score = 55.1 bits (131), Expect = 2e-07
Identities = 31/98 (31%), Positives = 50/98 (50%), Gaps = 11/98 (11%)
Query: 397 LIGNVIVRNISYEKRVIVRYTLDSWKSQQDVESVWITNHCNLKSGTGAIDIDVFQFAIDL 456
+ G V+N+++EK V +R T D+WKS D ++ K D D F F I L
Sbjct: 145 IAGTAKVQNLAFEKTVKIRMTFDTWKSYTDFPCQYV------KDTYAGSDRDTFSFDISL 198
Query: 457 -GKINTIEHIEMCILYQTREGSSWIDHWDNNSGQNYKV 493
KI + E +E + Y+ + +WD+N G+NY++
Sbjct: 199 PEKIQSYERMEFAVYYECNGQT----YWDSNRGKNYRI 232
>Hs4506011 [OT] KOG3986 Protein phosphatase regulatory subunit PPP1R3C/D
Length = 1122
Score = 53.1 bits (126), Expect = 9e-07
Identities = 30/93 (32%), Positives = 47/93 (50%), Gaps = 9/93 (9%)
Query: 399 GNVIVRNISYEKRVIVRYTLDSWKSQQDVESVWITNHCNLKSGTGAIDIDVFQFAIDLGK 458
G + V N+S+EK V VR +LD W++ D+ + ++ N C+ G D F+ +
Sbjct: 144 GIIRVLNVSFEKLVYVRMSLDDWQTHYDILAEYVPNSCD-----GETDQFSFKIVLVPPY 198
Query: 459 INTIEHIEMCILYQTREGSSWIDHWDNNSGQNY 491
+E CI Y+T G+ W NN+G NY
Sbjct: 199 QKDGSKVEFCIRYETSVGT----FWSNNNGTNY 227
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.315 0.132 0.386
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,017,126
Number of Sequences: 60738
Number of extensions: 1200154
Number of successful extensions: 2495
Number of sequences better than 1.0e-05: 10
Number of HSP's better than 0.0 without gapping: 1
Number of HSP's successfully gapped in prelim test: 9
Number of HSP's that attempted gapping in prelim test: 2472
Number of HSP's gapped (non-prelim): 15
length of query: 498
length of database: 30,389,216
effective HSP length: 111
effective length of query: 387
effective length of database: 23,647,298
effective search space: 9151504326
effective search space used: 9151504326
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)