BLASTP 2.0.10 [Aug-26-1999]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= PAB0069 (RfcL) DE:activator 1, replication factor C, large
subunit
(479 letters)
Database: ./suso.pep; /banques/blast2/nr.pep
598,487 sequences; 189,106,746 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
pir||D75198 activator 1, replication factor c, large s ubunit PA... 949 0.0
pir||G71231 probable replication factor C subunit - Pyrococcus h... 818 0.0
dbj|BAA88155.1| (AB034755) replication factor C large subunit [P... 799 0.0
pir||D64410 replication factor C large chain homolog - Methanoco... 328 1e-88
gi|11498795 activator 1, replication factor C, 53 KD subunit [Ar... 285 7e-76
pir||A69130 replication factor C, large subunit - Methanobacteri... 264 1e-69
gb|AAG19883.1| (AE005072) replication factor C large subunit; Rf... 235 9e-61
gb|AAK41066.1| Activator 1, replication factor C (RFC) large sub... 222 5e-57
emb|CAB57534.1| (Y18930) replication factor C, large subunit [Su... 222 5e-57
pir||E72633 probable replication factor C subunit APE1524 - Aero... 194 2e-48
emb|CAC12408.1| (AL445067) replication factor C subunit related ... 178 9e-44
gb|AAF18689.1|AC010795_4 (AC010795) replication factor, putative... 119 6e-26
pir||T37746 activator 1 subunit (replication factor subunit) - f... 119 8e-26
gi|11177922 replication factor C (activator 1) 2 (40kD) [Mus mus... 118 1e-25
sp|P53033|AC14_CHICK ACTIVATOR 1 40 KD SUBUNIT (REPLICATION FACT... 116 4e-25
gi|6324478 Subunit 4 of Replication Factor C; homologous to huma... 116 7e-25
gi|4506487 replication factor C (activator 1) 2 (40kD) [Homo sap... 115 9e-25
pir||A42700 replication factor C - human 115 1e-24
gi|11499642 activator 1, replication factor C, 35 KD subunit [Ar... 113 3e-24
pir||C72633 probable replication factor C subunit APE1522 - Aero... 112 8e-24
gb|AAK41065.1| Activator 1, replication factor C, small subunit ... 112 1e-23
sp|P53034|AC14_DROME ACTIVATOR 1 40 KDA SUBUNIT (REPLICATION FAC... 112 1e-23
emb|CAB57535.1| (Y18930) activator 1, replication factor C, smal... 112 1e-23
emb|CAA07618.1| (AJ007712) replication factor C subunit [Arxula ... 109 9e-23
gb|AAB88360.1| (AF036699) strong similarity to the activator 1 3... 108 1e-22
pir||B69130 replication factor C, small subunit - Methanobacteri... 106 6e-22
gi|6324039 Subunit 3 of Replication Factor C; homologous to huma... 104 2e-21
gi|6677723 replication factor C (activator 1) 5 (36.5kD) [Homo s... 103 4e-21
gi|4506491 replication factor C (activator 1) 4 (37kD) [Homo sap... 103 4e-21
pir||A45253 activator 1 37K chain - human 102 8e-21
gb|AAG20394.1| (AE005112) replication factor C small subunit; Rf... 99 7e-20
pir||D71603 replication factor C, 140 kDa subunit (ATPase) PFB08... 99 1e-19
pir||T43410 replication factor C chain Rfc3 - fission yeast (Sc... 99 1e-19
emb|CAC12618.1| (AL445067) probable replication factor C, 40 KD ... 98 3e-19
dbj|BAB16439.1| (AB038319) replication factor C 36kDa subunit [O... 96 6e-19
pir||H71604 replication factor C, 40 kDa subunit (replication ac... 96 8e-19
gb|AAG37987.1|AF071409_1 (AF071409) replication factor C subunit... 96 8e-19
pir||A49393 activator 1 large chain - mouse >gi|405112|gb|AAA216... 95 2e-18
gb|AAF63387.1|AF247499_1 (AF247499) replication factor C subunit... 94 4e-18
pir||A56284 differentiation-specific element binding protein - m... 93 6e-18
gi|6755306 replication factor C, 140 kDa [Mus musculus] >gi|1703... 93 7e-18
gb|AAF07781.1|AC010704_6 (AC010704) putative replication factor ... 92 9e-18
dbj|BAB16441.1| (AB045677) replication factor C 37kDa subunit [O... 92 9e-18
gb|AAC52140.1| (U07157) ISRE-binding protein [Mus musculus] 92 1e-17
gb|AAD41422.1|AC007727_11 (AC007727) Similar to gb|M87339 replic... 92 2e-17
gb|AAD01890.1| (AF030050) replication factor C [Rattus norvegicus] 91 3e-17
gb|AAG37985.1|AF069296_1 (AF069296) replication factor C3 [Plasm... 90 5e-17
gb|AAC60361.1| (U60144) replication factor C large subunit [Anas... 90 6e-17
pir||D72344 DNA polymerase III, gamma and tau subunit - Thermoto... 90 6e-17
gi|6322528 Subunit 2 of Replication Factor C; homologous to huma... 89 1e-16
gb|AAF69583.1|AC019154_2 (AC019154) Replication Factor C [Leishm... 87 4e-16
gi|4506485 replication factor C (activator 1) 1 (145kD) [Homo sa... 85 2e-15
gi|11435908 replication factor C (activator 1) 1 (145kD) [Homo s... 85 2e-15
sp|P35251|AC15_HUMAN ACTIVATOR 1 140 KDA SUBUNIT (REPLICATION FA... 84 3e-15
sp|Q09843|RFC2_SCHPO PROBABLE ACTIVATOR 1 41 KD SUBUNIT (REPLICA... 84 3e-15
pir||T39941 hypothetical protein SPBC23E6.07c - fission yeast (... 82 1e-14
gi|6324791 Subunit 1 of Replication Factor C; homologous to huma... 82 1e-14
sp|P35600|GNF1_DROME GERMLINE TRANSCRIPTION FACTOR 1 >gi|304728|... 81 2e-14
gb|AAB58311.1| (U97685) replication factor C large subunit [Dros... 81 2e-14
pir||T18305 replication factor C like protein - Emericella nidul... 81 3e-14
pir||T18306 replication factor C protein - Emericella nidulans >... 81 3e-14
pir||T20230 hypothetical protein C54G10.2 - Caenorhabditis elega... 81 3e-14
sp|P53016|AC12_CAEEL PUTATIVE ACTIVATOR 1 37 KD SUBUNIT (REPLICA... 80 5e-14
sp|P34429|AC11_CAEEL PUTATIVE ACTIVATOR 1 36 KD SUBUNIT (REPLICA... 80 5e-14
pir||T50383 homolog to yeast chl12 protein [imported] - fission ... 80 7e-14
emb|CAB92098.1| (AL356333) Replication factor C 36 KD subunit; a... 79 9e-14
gb|AAG21804.1|AF210454_2 (AF210454) replication factor C subunit... 75 2e-12
gb|AAF48768.1| (AE003506) CG8142 gene product [Drosophila melano... 74 3e-12
dbj|BAB03292.1| (AB037375) replication factor C small subunit pr... 73 5e-12
pir||F71231 probable replication factor C subunit - Pyrococcus h... 72 1e-11
gb|AAF52944.1| (AE003628) RfC3 gene product [Drosophila melanoga... 71 2e-11
emb|CAB93386.1| (AL357523) conserved ATP/GTP binding protein [St... 71 3e-11
pir||C75339 conserved hypothetical protein - Deinococcus radiodu... 69 8e-11
>pir||D75198 activator 1, replication factor c, large s ubunit PAB0069 -
Pyrococcus abyssi (strain Orsay)
>gi|5457544|emb|CAB49035.1| (AJ248283) activator 1,
replication factor C, large s ubunit [Pyrococcus abyssi]
Length = 479
Score = 949 bits (2427), Expect = 0.0
Identities = 479/479 (100%), Positives = 479/479 (100%)
Query: 1 MPEVPWVEKYRPRRLSEIINQEDAISKVKAWIEAWLHGNPPKKKALLLAGPPGSGKTTTV 60
MPEVPWVEKYRPRRLSEIINQEDAISKVKAWIEAWLHGNPPKKKALLLAGPPGSGKTTTV
Sbjct: 1 MPEVPWVEKYRPRRLSEIINQEDAISKVKAWIEAWLHGNPPKKKALLLAGPPGSGKTTTV 60
Query: 61 YALAREYNFEVIELNASDERTYDKIARYVQAAYTMDILGKRRKIIFLDEADNIEPSGAPE 120
YALAREYNFEVIELNASDERTYDKIARYVQAAYTMDILGKRRKIIFLDEADNIEPSGAPE
Sbjct: 61 YALAREYNFEVIELNASDERTYDKIARYVQAAYTMDILGKRRKIIFLDEADNIEPSGAPE 120
Query: 121 IAKLIDRARNPIIMAANHYWEVPKEIRDRAELVEYKRLTQRDVINALVRILKREGITVPK 180
IAKLIDRARNPIIMAANHYWEVPKEIRDRAELVEYKRLTQRDVINALVRILKREGITVPK
Sbjct: 121 IAKLIDRARNPIIMAANHYWEVPKEIRDRAELVEYKRLTQRDVINALVRILKREGITVPK 180
Query: 181 EVLVEIAKRASGDLRAAINDLQTVVAGGYEDARYVLAYRDVEKTVFQALGLVFASDNAKR 240
EVLVEIAKRASGDLRAAINDLQTVVAGGYEDARYVLAYRDVEKTVFQALGLVFASDNAKR
Sbjct: 181 EVLVEIAKRASGDLRAAINDLQTVVAGGYEDARYVLAYRDVEKTVFQALGLVFASDNAKR 240
Query: 241 AKLAMMNLDMSPDEFLLWIDENIPHMYLKPEEMARAYEAISKADIYLGRAQRTGNYSLWR 300
AKLAMMNLDMSPDEFLLWIDENIPHMYLKPEEMARAYEAISKADIYLGRAQRTGNYSLWR
Sbjct: 241 AKLAMMNLDMSPDEFLLWIDENIPHMYLKPEEMARAYEAISKADIYLGRAQRTGNYSLWR 300
Query: 301 YAIDMMTAGVAVAGTKKRGFAKFYPPNTLKMLAESKEERSTRNSIIKKIMSEMHMSKLEA 360
YAIDMMTAGVAVAGTKKRGFAKFYPPNTLKMLAESKEERSTRNSIIKKIMSEMHMSKLEA
Sbjct: 301 YAIDMMTAGVAVAGTKKRGFAKFYPPNTLKMLAESKEERSTRNSIIKKIMSEMHMSKLEA 360
Query: 361 IETMKIIKTIFEKNLDLAAHFTVFLGLSEKEVEFLAGRENAGTIWGKALAIRRKLKKEEE 420
IETMKIIKTIFEKNLDLAAHFTVFLGLSEKEVEFLAGRENAGTIWGKALAIRRKLKKEEE
Sbjct: 361 IETMKIIKTIFEKNLDLAAHFTVFLGLSEKEVEFLAGRENAGTIWGKALAIRRKLKKEEE 420
Query: 421 KIRKERKEEEKVEVREEKPEEKVEEKREERETKKEKEKKEEKKAEKKGKQVTLFDFIKK 479
KIRKERKEEEKVEVREEKPEEKVEEKREERETKKEKEKKEEKKAEKKGKQVTLFDFIKK
Sbjct: 421 KIRKERKEEEKVEVREEKPEEKVEEKREERETKKEKEKKEEKKAEKKGKQVTLFDFIKK 479
>pir||G71231 probable replication factor C subunit - Pyrococcus horikoshii
>gi|3256499|dbj|BAA29182.1| (AP000001) 468aa long
hypothetical replication factor C subunit [Pyrococcus
horikoshii]
Length = 468
Score = 818 bits (2089), Expect = 0.0
Identities = 405/480 (84%), Positives = 447/480 (92%), Gaps = 14/480 (2%)
Query: 1 MPEVPWVEKYRPRRLSEIINQEDAISKVKAWIEAWLHGNPPKKKALLLAGPPGSGKTTTV 60
MP+VPW+EKYRPR+LSEI+NQE A+ KV+AWIE+WLHGNPPKKKALLLAGPPGSGKTTTV
Sbjct: 1 MPDVPWIEKYRPRKLSEIVNQEQALEKVRAWIESWLHGNPPKKKALLLAGPPGSGKTTTV 60
Query: 61 YALAREYNFEVIELNASDERTYDKIARYVQAAYTMDILGKRRKIIFLDEADNIEPSGAPE 120
YALA EYNFEVIELNASDERTY+KIARYVQAAYTMDI+GKRRKIIFLDEADNIEPSGAPE
Sbjct: 61 YALAHEYNFEVIELNASDERTYNKIARYVQAAYTMDIMGKRRKIIFLDEADNIEPSGAPE 120
Query: 121 IAKLIDRARNPIIMAANHYWEVPKEIRDRAELVEYKRLTQRDVINALVRILKREGITVPK 180
IAKLID+ARNPIIMAANHYWEVPKEIRDRAELVEYKRL QRDVI+ALVRILKREGITVPK
Sbjct: 121 IAKLIDKARNPIIMAANHYWEVPKEIRDRAELVEYKRLNQRDVISALVRILKREGITVPK 180
Query: 181 EVLVEIAKRASGDLRAAINDLQTVVAGGYEDARYVLAYRDVEKTVFQALGLVFASDNAKR 240
E+L EIAKR+SGDLRAAINDLQT+VAGGYEDA+YVLAYRDVEKTVFQ+LG+VF+SDNAKR
Sbjct: 181 EILTEIAKRSSGDLRAAINDLQTIVAGGYEDAKYVLAYRDVEKTVFQSLGMVFSSDNAKR 240
Query: 241 AKLAMMNLDMSPDEFLLWIDENIPHMYLKPEEMARAYEAISKADIYLGRAQRTGNYSLWR 300
AKLA+MNLDMSPDEFLLW+DENIPHMYLKPEEMARAYEAIS+ADIYLGRAQRTGNYSLW+
Sbjct: 241 AKLALMNLDMSPDEFLLWVDENIPHMYLKPEEMARAYEAISRADIYLGRAQRTGNYSLWK 300
Query: 301 YAIDMMTAGVAVAGTKKRGFAKFYPPNTLKMLAESKEERSTRNSIIKKIMSEMHMSKLEA 360
YAIDMMTAGVAVAGTKK+GFAKFYPPNTLKMLAESKEERS R+SIIKKIM EMHMSKLEA
Sbjct: 301 YAIDMMTAGVAVAGTKKKGFAKFYPPNTLKMLAESKEERSIRDSIIKKIMKEMHMSKLEA 360
Query: 361 IETMKIIKTIFEKNLDLAAHFTVFLGLSEKEVEFLAGRENAGTIWGKALAIRRKLKKEEE 420
+ETMKI++TIFE NLDLAAHFTVFL L+EKEVEFLAG+E AGTIWGK L+IRR++
Sbjct: 361 LETMKILRTIFENNLDLAAHFTVFLELTEKEVEFLAGKEKAGTIWGKTLSIRRRI----- 415
Query: 421 KIRKERKEEEKVEVREEKPEEKVEEKREERETKKEKEKKEEKKAE-KKGKQVTLFDFIKK 479
KE EK+E E+ EEKVEE+ E E ++E++++E+ KAE KKGKQVTLFDFIKK
Sbjct: 416 ------KETEKIE--EKAVEEKVEEEEAEEEEEEERKEEEKPKAEKKKGKQVTLFDFIKK 467
>dbj|BAA88155.1| (AB034755) replication factor C large subunit [Pyrococcus furiosus]
Length = 479
Score = 799 bits (2040), Expect = 0.0
Identities = 397/482 (82%), Positives = 443/482 (91%), Gaps = 6/482 (1%)
Query: 1 MPEVPWVEKYRPRRLSEIINQEDAISKVKAWIEAWLHGNPPKKKALLLAGPPGSGKTTTV 60
MPE+PWVEKYRP++LSEI+NQE+AI KV+AWIE+WLHG+PPKKKALLLAGPPGSGKTTTV
Sbjct: 1 MPELPWVEKYRPKKLSEIVNQEEAIEKVRAWIESWLHGHPPKKKALLLAGPPGSGKTTTV 60
Query: 61 YALAREYNFEVIELNASDERTYDKIARYVQAAYTMDILGKRRKIIFLDEADNIEPSGAPE 120
YALA EYNFEVIELNASDERTY+KI+RYVQAAYTMDILGKRRKIIFLDEADNIEPSGA E
Sbjct: 61 YALANEYNFEVIELNASDERTYEKISRYVQAAYTMDILGKRRKIIFLDEADNIEPSGAKE 120
Query: 121 IAKLIDRARNPIIMAANHYWEVPKEIRDRAELVEYKRLTQRDVINALVRILKREGITVPK 180
IAKLID+A+NPIIMAAN YWEVPKEIR++AELVEYKRLTQRDV+NAL+RILKREGITVPK
Sbjct: 121 IAKLIDKAKNPIIMAANKYWEVPKEIREKAELVEYKRLTQRDVMNALIRILKREGITVPK 180
Query: 181 EVLVEIAKRASGDLRAAINDLQTVVAGGYEDARYVLAYRDVEKTVFQALGLVFASDNAKR 240
E+L+EIAKR+SGDLRAAINDLQTVV GGYEDA VLAYRDVEKTVFQALGLVF SDNAKR
Sbjct: 181 EILLEIAKRSSGDLRAAINDLQTVVVGGYEDATQVLAYRDVEKTVFQALGLVFGSDNAKR 240
Query: 241 AKLAMMNLDMSPDEFLLWIDENIPHMYLKPEEMARAYEAISKADIYLGRAQRTGNYSLWR 300
AK+AM NLDMSPDEFLLW+DENIPH+YL PEE+A+AY+AIS+ADIYLGRA RTGNYSLW+
Sbjct: 241 AKMAMWNLDMSPDEFLLWVDENIPHLYLNPEEIAQAYDAISRADIYLGRAARTGNYSLWK 300
Query: 301 YAIDMMTAGVAVAGTKKRGFAKFYPPNTLKMLAESKEERSTRNSIIKKIMSEMHMSKLEA 360
YAIDMMTAGVAVAG K+RGF KFYPPNTLK+LAESKEER R SIIKKI+ EMHMS+L+A
Sbjct: 301 YAIDMMTAGVAVAGRKRRGFVKFYPPNTLKILAESKEEREIRESIIKKIIREMHMSRLQA 360
Query: 361 IETMKIIKTIFEKNLDLAAHFTVFLGLSEKEVEFLAGRENAGTIWGKALAIRRKLKKEEE 420
IETMKII+ IFE NLDLAAHFTVFLGLSEKEVEFLAG+E AGTIWGKALA+RRKLK E
Sbjct: 361 IETMKIIREIFENNLDLAAHFTVFLGLSEKEVEFLAGKEKAGTIWGKALALRRKLK--EL 418
Query: 421 KIRKERKEEEKVEVREEKPEEKVEEKREERETKKEKEKKEEKKAE---KKGKQVTLFDFI 477
IR+E K + ++E EE+ EEK EE++EE E K E+EK+EEKK + KKGKQ TLFDF+
Sbjct: 419 GIREEEKPKVEIE-EEEEEEEKTEEEKEEIEEKPEEEKEEEKKEKEKPKKGKQATLFDFL 477
Query: 478 KK 479
KK
Sbjct: 478 KK 479
>pir||D64410 replication factor C large chain homolog - Methanococcus jannaschii
>gi|1591562|gb|AAB98888.1| (U67532) activator 1
(replication factor C), 53 KD subunit [Methanococcus
jannaschii]
Length = 516
Score = 328 bits (831), Expect = 1e-88
Identities = 204/517 (39%), Positives = 293/517 (56%), Gaps = 48/517 (9%)
Query: 6 WVEKYRPRRLSEIINQEDAISKVKAWIEAWLHGNPPKKKALLLAGPPGSGKTTTVYALAR 65
WVEKYRP+ L ++ E K+K WIE++L G PK +LL GPPG GKTT YALA
Sbjct: 4 WVEKYRPKSLKDVAGHEKVKEKLKTWIESYLKGETPKP--ILLVGPPGCGKTTLAYALAN 61
Query: 66 EYNFEVIELNASDERTYDKIARYVQAAYTMDILGKRRKIIFLDEADNI----EPSGAPEI 121
+Y FEVIELNASD+R I + V A T + ++ +I LDE D I + G E+
Sbjct: 62 DYGFEVIELNASDKRNSSAIKKVVGHAATSSSIFGKKFLIVLDEVDGISGKEDAGGVSEL 121
Query: 122 AKLIDRARNPIIMAANH-YWEVPKEIRDRAELVEYKRLTQRDVINALVRILKREGITVPK 180
K+I +A+NPII+ AN Y + + E+++ + V L +I ++EG+ V
Sbjct: 122 IKVIKKAKNPIILTANDAYAPSIRSLLPYVEVIQLNPVHTNSVYKVLKKIAEKEGLDVDD 181
Query: 181 EVLVEIAKRASGDLRAAINDLQTVVAGG---YEDARYVLAYRDVEKTVFQALGLVFASDN 237
+ L IA+ ++GDLR+AINDL+ + G YE A+ L R E +F AL ++ + +
Sbjct: 182 KTLKMIAQHSAGDLRSAINDLEALALSGDLSYEAAQK-LPDRKREANIFDALRVILKTTH 240
Query: 238 AKRAKLAMMNLDMSPDEFLLWIDENIPHMYLKPEEMARAYEAISKADIYLGRAQRTGNYS 297
A A+MN+D +PD + WI EN+P Y KPEE+ARA+E +SKAD YLGR R NYS
Sbjct: 241 YGIATTALMNVDETPDVVIEWIAENVPKEYEKPEEVARAFEYLSKADRYLGRVMRRQNYS 300
Query: 298 LWRYAIDMMTAGVAVAGTKK-RGFAKFYPPNTLKMLAESKEERSTRNSIIKKIMSEMHMS 356
W+YA +MTAGVA++ +K R + + P ++L ++K ER N I+KKI + H S
Sbjct: 301 FWKYATTLMTAGVALSKDEKYRKWTPYSYPKIFRLLTKTKAEREILNKILKKIGEKTHTS 360
Query: 357 KLEAIETMKIIKTIFEKNLDLAAHFTVFLGLSEKEVEFLAGRENAG---TIWGKALAIRR 413
A ++++K + ++N +AA + + E E++ L G + A I + + R
Sbjct: 361 SKRARFDLQMLKLLAKENPSVAADLVDYFEIKEDELKVLVGDKLASEILKILKEKKKLER 420
Query: 414 KLKKEEEKIRKERKEEEKV--------------------------EVRE---EKP---EE 441
K KKE+EK+ KE+K+EEK EV+E EKP E
Sbjct: 421 KKKKEKEKLEKEKKKEEKAKEKQSNLIIQPKEIKEEVKAEVEKKEEVKEKIVEKPKAEEV 480
Query: 442 KVEEKREERETKKEKEKKEEKKAEKKGKQVTLFDFIK 478
K + K EE+ETKK+K KK +KK E KGKQ+TL F K
Sbjct: 481 KEKSKTEEKETKKDK-KKGKKKKEDKGKQLTLDAFFK 516
>gi|11498795 activator 1, replication factor C, 53 KD subunit [Archaeoglobus
fulgidus] >gi|7450123|pir||B69399 activator 1,
replication factor C, 53 KD subunit homolog -
Archaeoglobus fulgidus >gi|2649392|gb|AAB90051.1|
(AE001022) activator 1, replication factor C, 53 KD
subunit [Archaeoglobus fulgidus]
Length = 479
Score = 285 bits (722), Expect = 7e-76
Identities = 184/492 (37%), Positives = 274/492 (55%), Gaps = 38/492 (7%)
Query: 6 WVEKYRPRRLSEIINQEDAISKVKAWIEAWLHGNPPKKKALLLAGPPGSGKTTTVYALAR 65
WVEKYRP+ L E++ + I++V W ++W G+ P LLLAGPPG GKT+ ALA
Sbjct: 3 WVEKYRPKTLEEVVADKSIITRVIKWAKSWKRGSKP----LLLAGPPGVGKTSLALALAN 58
Query: 66 EYNFEVIELNASDERTYDKIARYV-----------QAAYTMDILGKRRKIIFLDEADNI- 113
+E +ELNASD+R++ I R V + + +GK K+I LDE DNI
Sbjct: 59 TMGWEAVELNASDQRSWRVIERIVGEGAFNETISDEGEFLSSRIGKL-KLIILDEVDNIH 117
Query: 114 ---EPSGAPEIAKLIDRA-RNPIIMAANHYWEVPKEIRDRAELVEYKRLTQRDVINALVR 169
+ G + +LI R P+I+ AN +++ E+R+ E++ +KRLT++ V L R
Sbjct: 118 KKEDVGGEAALIRLIKRKPAQPLILIANDPYKLSPELRNLCEMINFKRLTKQQVARVLER 177
Query: 170 ILKREGITVPKEVLVEIAKRASGDLRAAINDLQTVVAGGYE--DARYVLAYRDVEKTVFQ 227
I +EGI V K VL++IA+ A GDLRAAIND Q + G E L R EK +F+
Sbjct: 178 IALKEGIKVDKSVLLKIAENAGGDLRAAINDFQALAEGKEELKPEDVFLTKRTQEKDIFR 237
Query: 228 ALGLVFASDNAKRAKLAMMNLDMSPDEFLLWIDENIPHMYLKPEEMARAYEAISKADIYL 287
+ ++F + N AM+ LD SP++ + W+DEN+P Y E+ AYEA+S+ADI+L
Sbjct: 238 VMQMIFKTKNPAVYNEAML-LDESPEDVIHWVDENLPLEY-SGVELVNAYEALSRADIFL 295
Query: 288 GRAQRTGNYSLWRYAIDMMTAGVA-VAGTKKRGFAKFYPPNTLKMLAESKEERSTRNSII 346
GR +R Y LW+YA +MT GV + K+GF ++ P +ML + +++R I+
Sbjct: 296 GRVRRRQFYRLWKYASYLMTVGVQQMKEEPKKGFTRYRRPAVWQMLFQLRQKREMTRKIL 355
Query: 347 KKIMSEMHMSKLEA-IETMKIIKTIF-EKNLDLAAHFTVFLGLSEKEVEFLAGRENAGTI 404
+KI H+S +A E +IK + E ++D AA F +++E+EFL G E I
Sbjct: 356 EKIGKYSHLSMRKARTEMFPVIKLLLKELDVDKAATIAAFYEFTKEELEFLVG-EKGDEI 414
Query: 405 WGKALAIRRKLKKEEEKIRKERKEEEKVEVREEKPEEKVEEKREERETKKEKEKKEEKKA 464
W + K +I E E V+ +E+ EE VEE EE K E+E++E +
Sbjct: 415 W------KYVEKHGMHRIEDETFLESFVKAEKEEKEESVEEVAEE---KPEEEREEPRAR 465
Query: 465 EKKGKQVTLFDF 476
+K GK +TL F
Sbjct: 466 KKAGKNLTLDSF 477
>pir||A69130 replication factor C, large subunit - Methanobacterium
thermoautotrophicum (strain Delta H)
>gi|2621289|gb|AAB84746.1| (AE000811) replication factor
C, large subunit [Methanobacterium thermoautotrophicum]
Length = 479
Score = 264 bits (668), Expect = 1e-69
Identities = 162/489 (33%), Positives = 273/489 (55%), Gaps = 31/489 (6%)
Query: 6 WVEKYRPRRLSEIINQEDAISKVKAWIEAWLHGNPPKKKALLLAGPPGSGKTTTVYALAR 65
W EKYRP E++ + I+++K WI+AW G P +K LLL GPPG+GKTT + + +
Sbjct: 3 WTEKYRPGSFDEVVGNQKVIAEIKEWIKAWKAGKP--QKPLLLVGPPGTGKTTLAHIIGK 60
Query: 66 EYNFEVIELNASDERTYDKIARYV-QAAYTMDILGKRRKIIFLDEADNI----EPSGAPE 120
E++ + +ELNASD R+ D + R +A+ T + K+I LDE D I + G
Sbjct: 61 EFS-DTLELNASDRRSQDALMRSAGEASATRSLFNHDLKLIILDEVDGIHGNEDRGGVQA 119
Query: 121 IAKLIDRARNPIIMAANH-YWEVPKEIRDRAELVEYKRLTQRDVINALVRILKREGITVP 179
I ++I +R+P+++ AN Y + + I+ R ++ +++ + AL RI + EGI P
Sbjct: 120 INRIIKESRHPMVLTANDPYSKRLQSIKPRCRVLNLRKVHTSSIAAALRRICRAEGIECP 179
Query: 180 KEVLVEIAKRASGDLRAAINDLQTVVAGGYEDARYVLAY--RDVEKTVFQALGLVFASDN 237
+VL E+AKR+ GDLR+AINDL+ + G +L +D +F A+ V S +
Sbjct: 180 DDVLRELAKRSRGDLRSAINDLEAMAEGEERIGEELLKMGEKDATSNLFDAVRAVLKSRD 239
Query: 238 AKRAKLAMMNLDMSPDEFLLWIDENIPHMYLKPEEMARAYEAISKADIYLGRAQRTGNYS 297
+ + AM +D P L +I EN+P Y KP E++RAY+ +S+ADI+ GRA RT NY+
Sbjct: 240 VSKVREAM-RVDDDPTLVLEFIAENVPREYEKPNEISRAYDMLSRADIFFGRAVRTRNYT 298
Query: 298 LWRYAIDMMTAGVAVAGTKK-RGFAKFYPPNTLKMLAESKEERSTRNSIIKKIMSEMHMS 356
WRYA ++M GVA+A K R F ++ ++ ++L +++++RS R+S+ K+ +MH+S
Sbjct: 299 YWRYASELMGPGVALAKDKTYRKFVRYTGSSSFRILGKTRKQRSLRDSVAAKMAGKMHIS 358
Query: 357 KLEAIETMKIIKTIFEKNLDLAAHFTVFLGLSEKEVEFLAGRENAGTIWGKALAIRRKLK 416
AI ++ +FE N ++A + FL L ++E++ R+ KA ++ +
Sbjct: 359 PKVAISMFPYMEILFE-NDEMAYDISEFLELRDEEIKLFRKRKI------KAPKRKKTPR 411
Query: 417 KEEEKI------RKERKEEEKVEVREEKPEEKV---EEKREERETKKEKEKKEEKKAEKK 467
K E K+ +K++ ++ + + K K+++R + ++KK K
Sbjct: 412 KAEIKVGPLYSQKKDKGADKSINDKATDKSAKTPIKSSKKDDRPRDESSSSSDDKK--PK 469
Query: 468 GKQVTLFDF 476
KQ +LF F
Sbjct: 470 EKQTSLFQF 478
>gb|AAG19883.1| (AE005072) replication factor C large subunit; RfcB [Halobacterium
sp. NRC-1]
Length = 501
Score = 235 bits (593), Expect = 9e-61
Identities = 140/412 (33%), Positives = 229/412 (54%), Gaps = 28/412 (6%)
Query: 4 VPWVEKYRPRRLSEIINQEDAISKVKAWIEAWLHGNPPKKKALLLAGPPGSGKTTTVYAL 63
V W EKYRP LSE+ + A + W E W P ++A+++ G PG GKT+ +AL
Sbjct: 32 VDWTEKYRPASLSEVRGNDTARDALAEWAETW----PDHREAVVVHGSPGIGKTSAAHAL 87
Query: 64 AREYNFEVIELNASDERTYDKIARYV-QAAYTMDILGKR--RKIIFLDEADN----IEPS 116
A + ++V+ELNASD+RT D + R +AA + + G RK++ LDEADN I+
Sbjct: 88 ANDAGWDVVELNASDQRTADVVERVAGEAARSGTLTGGSGGRKLVLLDEADNLHGNIDRG 147
Query: 117 GAPEIAKLIDRARNPIIMAANHYWEVPKEIRDRAELVEYKRLTQRDVINALVRILKREGI 176
G+ I +L+D A PI++ AN Y+E+ +R +E++ +++R ++ L + +RE +
Sbjct: 148 GSAAITRLVDDAPQPIVLVANEYYEMSSSLRSACREIEFRDVSKRSIVPVLRDVCRREDV 207
Query: 177 TVPKEVLVEIAKRASGDLRAAINDLQTVVAGGYEDAR------YVLAYRDVEKTVFQALG 230
T ++ L IA++ +GDLR+A+NDLQ + E R V+ RD + VF L
Sbjct: 208 TYEEDALAAIAEQNAGDLRSAVNDLQALA----EQDRTLTADDVVMGERDRTEGVFDYLD 263
Query: 231 LVFASDNAKRAKLAMMNLDMSPDEFLLWIDENIPHMYLKPEEMARAYEAISKADIYLGRA 290
V A+ +A+ A A ++D +PD+ L W+ +N+P Y + E+A AYE +S AD++LGR
Sbjct: 264 DVIATHSAREALQAAYDVDETPDDLLSWVADNVPKDY-RGGELADAYEFLSNADVWLGRV 322
Query: 291 QRTGNYSLWRYAIDMMTAGVAVAGTKKR-GFAKFYPPNTLKMLAESKEERSTRNSIIKKI 349
+ T NY+ WRYA D + AGVA A G+ ++ PP+ + L S+ R R+ + + I
Sbjct: 323 RATQNYAYWRYATDNVAAGVAAARRHDHGGWTRYGPPSYWRKLGSSRATREKRDYVARHI 382
Query: 350 MS----EMHMSKLEAIETMKIIKTIFEKNLDLAAHFTVFLGLSEKEVEFLAG 397
M ++ + + ++++ T KN +L L + V F+ G
Sbjct: 383 AETAGCSMATARNDVLPFLRVL-THHCKNRELTVAMAAAYELDTEHVAFVTG 433
>gb|AAK41066.1| Activator 1, replication factor C (RFC) large subunit (rfcL)
[Sulfolobus solfataricus]
Length = 405
Score = 222 bits (561), Expect = 5e-57
Identities = 152/410 (37%), Positives = 231/410 (56%), Gaps = 28/410 (6%)
Query: 4 VPWVEKYRPRRLSEIINQEDAISKVKAWIEAWLHGNPPKKKALLLAGPPGSGKTTTVYAL 63
+ W KYRPR L ++ NQ+DA +++ WIE+WL+GN KA+LL GPPG GKT AL
Sbjct: 2 IQWFLKYRPRSLKDVENQDDAKKQLQEWIESWLNGNS-NVKAVLLHGPPGVGKTVLAEAL 60
Query: 64 AREYNFEVIELNASDERTYDKIARYVQ-AAYTMDILGKRRKIIFLDEADNI---EPSGAP 119
A +YNFE++E+NASD R I + AA I G + K+I LDE D I E +GA
Sbjct: 61 AHDYNFELLEMNASDSRKLQDIKSIAEKAAVYGSIFGTKGKLILLDEVDGINVREDTGAI 120
Query: 120 E-IAKLIDRARNPIIMAANHYWEVP-KEIRDRAELVEYKRLTQRDVINALVRILKREGIT 177
+ I +LI++ + PIIM AN W +E+R++A+++E +L + + L +I + E I
Sbjct: 121 QGILELIEKTKYPIIMTANDPWNPGLRELRNKAKMIELSKLGKYPLRRILKKICQAEKII 180
Query: 178 VPKEVLVEIAKRASGDLRAAINDLQTVVAGGYEDARYVLA-----YRDVEKTVFQALGLV 232
E L I + GD R AIN LQ + GY L ++ E F+ L +
Sbjct: 181 CDDEALNYIIDSSEGDARYAINILQG-IGEGYGKVTLNLVESLAKRKERELDPFETLRDI 239
Query: 233 FASDNAKRAKLAMMNLDMSPDEFLLWIDENIPHMYLKPEEMARAYEAISKADIYLGRAQR 292
F + A +AK A + + D + WI ENIP Y E++ RA++A+S+A I+L RA +
Sbjct: 240 FWARYAWQAKNAATSAQIDYDMLIRWISENIPIQYDNIEDIWRAFDALSRASIFLKRA-K 298
Query: 293 TGNYSLWRYAIDMMTAGVAVAGTKKR------GFAKFYPPNTLKMLAESKEERSTRNSII 346
+G++ L YA DMM++GVA A +K+ + K+ P+ +++L++SK+ R TR+ II
Sbjct: 299 SGDWDLLSYAYDMMSSGVAFAEPEKKKPNWKPKWKKYQFPSYIQLLSKSKDIRDTRDEII 358
Query: 347 KKIMSEMHMSKLEAIETMKIIKTIFEKNLDLAAHFTVFLGLSEKEVEFLA 396
KK+ +H S +A+ +F K D L L+ KE E+L+
Sbjct: 359 KKL--AIHSSFNKALNDTYPFFLLFYKKYD------KHLNLNTKEKEYLS 400
>emb|CAB57534.1| (Y18930) replication factor C, large subunit [Sulfolobus
solfataricus]
Length = 405
Score = 222 bits (561), Expect = 5e-57
Identities = 152/410 (37%), Positives = 231/410 (56%), Gaps = 28/410 (6%)
Query: 4 VPWVEKYRPRRLSEIINQEDAISKVKAWIEAWLHGNPPKKKALLLAGPPGSGKTTTVYAL 63
+ W KYRPR L ++ NQ+DA +++ WIE+WL+GN KA+LL GPPG GKT AL
Sbjct: 2 IQWFLKYRPRSLKDVENQDDAKKQLQEWIESWLNGNS-NVKAVLLHGPPGVGKTVLAEAL 60
Query: 64 AREYNFEVIELNASDERTYDKIARYVQ-AAYTMDILGKRRKIIFLDEADNI---EPSGAP 119
A +YNFE++E+NASD R I + AA I G + K+I LDE D I E +GA
Sbjct: 61 AHDYNFELLEMNASDSRKLQDIKSIAEKAAVYGSIFGTKGKLILLDEVDGINVREDTGAI 120
Query: 120 E-IAKLIDRARNPIIMAANHYWEVP-KEIRDRAELVEYKRLTQRDVINALVRILKREGIT 177
+ I +LI++ + PIIM AN W +E+R++A+++E +L + + L +I + E I
Sbjct: 121 QGILELIEKTKYPIIMTANDPWNPGLRELRNKAKMIELSKLGKYPLRRILKKICQAEKII 180
Query: 178 VPKEVLVEIAKRASGDLRAAINDLQTVVAGGYEDARYVLA-----YRDVEKTVFQALGLV 232
E L I + GD R AIN LQ + GY L ++ E F+ L +
Sbjct: 181 CDDEALNYIIDSSEGDARYAINILQG-IGEGYGKVTLNLVESLAKRKERELDPFETLRDI 239
Query: 233 FASDNAKRAKLAMMNLDMSPDEFLLWIDENIPHMYLKPEEMARAYEAISKADIYLGRAQR 292
F + A +AK A + + D + WI ENIP Y E++ RA++A+S+A I+L RA +
Sbjct: 240 FWARYAWQAKNAATSAQIDYDMLIRWISENIPIQYDNIEDIWRAFDALSRASIFLKRA-K 298
Query: 293 TGNYSLWRYAIDMMTAGVAVAGTKKR------GFAKFYPPNTLKMLAESKEERSTRNSII 346
+G++ L YA DMM++GVA A +K+ + K+ P+ +++L++SK+ R TR+ II
Sbjct: 299 SGDWDLLSYAYDMMSSGVAFAEPEKKKPNWKPKWKKYQFPSYIQLLSKSKDIRDTRDEII 358
Query: 347 KKIMSEMHMSKLEAIETMKIIKTIFEKNLDLAAHFTVFLGLSEKEVEFLA 396
KK+ +H S +A+ +F K D L L+ KE E+L+
Sbjct: 359 KKL--AIHSSFNKALNDTYPFFLLFYKKYD------KHLNLNTKEKEYLS 400
>pir||E72633 probable replication factor C subunit APE1524 - Aeropyrum pernix
(strain K1) >gi|5105209|dbj|BAA80523.1| (AP000061) 414aa
long hypothetical replication factor C subunit
[Aeropyrum pernix]
Length = 414
Score = 194 bits (487), Expect = 2e-48
Identities = 138/407 (33%), Positives = 213/407 (51%), Gaps = 21/407 (5%)
Query: 62 ALAREYNFEVIELNASDERTYDKIARYVQAAYTMDILGKRRKIIFLDEADNIEP----SG 117
A+A E+N E+IELNASD R I R V AA + KR +I LDE D I P G
Sbjct: 3 AIASEFNLEMIELNASDYRRRSDIERIVGAASRKRSMFKRGVVILLDEVDGINPREDAGG 62
Query: 118 APEIAKLIDRARNPIIMAANHYW-EVPKEIRDRAELVEYKRLTQRDVINALVRILKREGI 176
+ +I NPI+M AN W + + +R+ + +VE++ LT ++ L RI + E I
Sbjct: 63 IEALLSVIKTTENPIVMTANDPWKDFLRPLREVSLMVEFRPLTLTHIVAVLQRICEAERI 122
Query: 177 TVPKEVLVEIAKRASGDLRAAINDLQTVVAGGYED-----ARYVLAYRDVEKTVFQALGL 231
+E L IA+R+ GDLR+AINDLQ V A GY AR ++ R+ +++ L
Sbjct: 123 ECEREALRYIAERSEGDLRSAINDLQAV-AEGYGRVTLTLAREIVRGREKSIDIWRTLNQ 181
Query: 232 VFASDN-AKRAKLAMMNLDMSPDEFLLWIDENIPHMYLKPEEMARAYEAISKADIYLGRA 290
VF A A+ A+ + +E + WI++NIP Y +P ++ RA++A+++A ++LGRA
Sbjct: 182 VFYKPRQAWMARKAVSQSEKDYEELIAWINDNIPRKYGEPSDLFRAFDALARATVFLGRA 241
Query: 291 QRTGNYSLWRYAIDMMTAGVAVAGTKKRGFAKFYP-PNTLKMLAESKEERSTRNSIIKKI 349
+ GN+ L Y D+M GVA A + Y P ++M+A+ + R TR + + +
Sbjct: 242 KFGGNWELLSYVFDLMGPGVAYARMEGEVLKTRYSYPEKIRMMAQLRGVRETREKLAEVL 301
Query: 350 MSEMHMSKLEA-IETMKIIKTIFEKNLD--LAAHFTVFLGLSEKEVEFLAGRENAGTIWG 406
+ MS+ E + I+ IF + D A + GL+EK VE LAG+ + +
Sbjct: 302 AKRLLMSRRAVKTEVLPILHYIFRSSRDPTKPAMIALEYGLTEKMVELLAGQRKSEIL-- 359
Query: 407 KALAIRRKLKKEEEKIRKERKEEEKVEVREEKPEEKVEEKREERETK 453
KA+A +K + E+ + +E K R EK K +RE K
Sbjct: 360 KAMATVKKARLGEKPL---EPQEAKARRRGEKASRDEGRKAGKRERK 403
>emb|CAC12408.1| (AL445067) replication factor C subunit related protein
[Thermoplasma acidophilum]
Length = 418
Score = 178 bits (448), Expect = 9e-44
Identities = 120/419 (28%), Positives = 206/419 (48%), Gaps = 29/419 (6%)
Query: 6 WVEKYRPRRLSEIINQEDAISKVKAWIEAWLHGNPPKKKALLLAGPPGSGKTTTVYALAR 65
W +KYRP+ + ++I + ++ WIE+W G P KK++L+L G G+GKTTT YA+A
Sbjct: 4 WADKYRPKNIDDVILNSEIRKQITEWIESWKEGIP-KKRSLILYGSQGTGKTTTAYAIAG 62
Query: 66 EYNFEVIELNASDERTYDKI-ARYVQAAYTMDIL---GKR-RKIIFLDEADNI-----EP 115
+ V+E+NASD+R D + + A+ D+ KR K+I +DEADN+ +
Sbjct: 63 TFGVPVVEMNASDQRNRDSMRGTALMASLYGDLFVESAKRPSKVILIDEADNMFERGGDT 122
Query: 116 SGAPEIAKLIDRARNPIIMAANHYWEVPK-----EIRDRAELVEYKRLTQ---------- 160
G E++K+I + NPI++ N +E K ++ + +E K+ +
Sbjct: 123 GGIYELSKIIKNSANPIVITMNDIFEFRKKNYASDVISASLTIEMKQYGRKLDKNYNEFR 182
Query: 161 RDVINALVRILKREGITVPKEVLVEIAKRASGDLRAAINDLQTVVAGGYEDARYVLAYRD 220
R++ L+ ILK EG T+P +V+ I R D+R+ INDL+ G + + RD
Sbjct: 183 RNIKARLIFILKNEGYTLPDQVVDRIIDRNMPDIRSMINDLEASAVSGTNISDQ--SSRD 240
Query: 221 VEKTVFQALGLVFASDNAKRAKLAMMNLDMSPDEFLLWIDENIPHMYLKPEEMARAYEAI 280
V + V+ + F N ++ D+ ++ WIDEN+P + +++ AYE I
Sbjct: 241 VPEIVYYMVDKAFKR-NYDDTLRSIYGSDIDDSYYVSWIDENLPLKTVDLQDLVSAYEVI 299
Query: 281 SKADIYLGRAQRTGNYSLWRYAIDMMTAGVAVAGTKKRGFAKFYPPNTLKMLAESKEERS 340
S AD L +R +Y L + +++ K + K+ P+ + ++++KE+R
Sbjct: 300 SYADHILWAMERRRHYELMAFPMEIAGGVAYYIENMKHEYVKYQSPSYISQMSKTKEKRH 359
Query: 341 TRNSIIKKIMSEMHMSKLEAIETMKIIKTIFEKNLDLAAHFTVFLGLSEKEVEFLAGRE 399
S+ KI +HM E + +++ N L F L L++ E L E
Sbjct: 360 AMMSLALKIGLLIHMGAQRTSEDLWFYSLLYQHNEKLRTFFEEKLNLTQGEENVLTRSE 418
>gb|AAF18689.1|AC010795_4 (AC010795) replication factor, putative; 74998-73295 [Arabidopsis
thaliana]
Length = 333
Score = 119 bits (296), Expect = 6e-26
Identities = 75/214 (35%), Positives = 117/214 (54%), Gaps = 19/214 (8%)
Query: 5 PWVEKYRPRRLSEIINQEDAISKVKAWIEAWLHGNPPKKKALLLAGPPGSGKTTTVYALA 64
PWVEKYRP ++ +I+ EDA+S+++ GN P L+L+GPPG+GKTT++ ALA
Sbjct: 16 PWVEKYRPSKVVDIVGNEDAVSRLQVIAR---DGNMPN---LILSGPPGTGKTTSILALA 69
Query: 65 RE-----YNFEVIELNASDERTYD----KIARYVQAAYTMDILGKRRKIIFLDEADNIEP 115
E Y V+ELNASD+R D KI + Q T+ R K++ LDEAD++
Sbjct: 70 HELLGTNYKEAVLELNASDDRGIDVVRNKIKMFAQKKVTLP--PGRHKVVILDEADSMTS 127
Query: 116 SGAPEIAKLIDRARNP--IIMAANHYWEVPKEIRDRAELVEYKRLTQRDVINALVRILKR 173
+ + I+ N +A N ++ + I+ R LV + RL+ + ++ L+ ++
Sbjct: 128 GAQQALRRTIEIYSNSTRFALACNTSAKIIEPIQSRCALVRFSRLSDQQILGRLLVVVAA 187
Query: 174 EGITVPKEVLVEIAKRASGDLRAAINDLQTVVAG 207
E + E L I A GD+R A+N+LQ +G
Sbjct: 188 EKVPYVPEGLEAIIFTADGDMRQALNNLQATFSG 221
>pir||T37746 activator 1 subunit (replication factor subunit) - fission yeast
(Schizosaccharomyces pombe) >gi|4106657|emb|CAA22597.1|
(AL035064) activator 1 subunit (replication factor
subunit) [Schizosaccharomyces pombe]
Length = 342
Score = 119 bits (295), Expect = 8e-26
Identities = 74/214 (34%), Positives = 115/214 (53%), Gaps = 15/214 (7%)
Query: 3 EVPWVEKYRPRRLSEIINQEDAISKVKAWIEAWLHGNPPKKKALLLAGPPGSGKTTTVYA 62
E+PWVEKYRP L +I+ E+ I ++K + GN P L+++G PG GKTT++
Sbjct: 20 ELPWVEKYRPIVLDDIVGNEETIDRLKVIAK---EGNMPH---LVISGMPGIGKTTSILC 73
Query: 63 LARE-----YNFEVIELNASDERTYDKIARYVQAAYTMDIL--GKRRKIIFLDEADNIEP 115
LA Y V+ELNASDER D + ++A ++ R KII LDEAD++
Sbjct: 74 LAHALLGPAYKEGVLELNASDERGIDVVRNRIKAFAQKKVILPPGRHKIIILDEADSMTA 133
Query: 116 SGAPEIAKLIDRARNP--IIMAANHYWEVPKEIRDRAELVEYKRLTQRDVINALVRILKR 173
+ + ++ N +A N ++ + I+ R ++ Y RLT + V+ L+ I K
Sbjct: 134 GAQQALRRTMEIYSNTTRFALACNQSNKIIEPIQSRCAILRYSRLTDQQVLQRLLNICKA 193
Query: 174 EGITVPKEVLVEIAKRASGDLRAAINDLQTVVAG 207
E + + L + A GD+R A+N+LQ+ VAG
Sbjct: 194 EKVNYTDDGLAALIMTAEGDMRQAVNNLQSTVAG 227
>gi|11177922 replication factor C (activator 1) 2 (40kD) [Mus musculus]
>gi|4972952|gb|AAD34861.1|AF139987_4 (AF139987)
replication factor C, 40kDa subunit [Mus musculus]
>gi|9800515|gb|AAF99332.1|AF289664_3 (AF289664) RFC2
[Mus musculus]
Length = 349
Score = 118 bits (294), Expect = 1e-25
Identities = 76/230 (33%), Positives = 125/230 (54%), Gaps = 20/230 (8%)
Query: 3 EVPWVEKYRPRRLSEIINQEDAISKVKAWIEAWLHGNPPKKKALLLAGPPGSGKTTTVYA 62
E+PWVEKYRP +L+EI+ ED +S+++ + GN P +++AGPPG+GKTT++
Sbjct: 30 ELPWVEKYRPLKLNEIVGNEDTVSRLEVFAR---EGNVPN---IIIAGPPGTGKTTSILC 83
Query: 63 LAREY-----NFEVIELNASDERTYD----KIARYVQAAYTMDILGKRRKIIFLDEADNI 113
LAR V+ELNAS++R D KI + Q T+ R KII LDEAD++
Sbjct: 84 LARALLGPALKDAVLELNASNDRGIDVVRNKIKMFAQQKVTLP--KGRHKIIILDEADSM 141
Query: 114 EPSGAPEIAKLID--RARNPIIMAANHYWEVPKEIRDRAELVEYKRLTQRDVINALVRIL 171
+ + ++ +A N ++ + I+ R ++ Y +LT V+ L+ ++
Sbjct: 142 TDGAQQALRRTMEIYSKTTRFALACNASDKIIEPIQSRCAVLRYTKLTDAQVLTRLMNVI 201
Query: 172 KREGITVPKEVLVEIAKRASGDLRAAINDLQTVVAG-GYEDARYVLAYRD 220
++E + + L I A GD+R A+N+LQ+ +G GY ++ V D
Sbjct: 202 EKEKVPYTDDGLEAIIFTAQGDMRQALNNLQSTFSGFGYINSENVFKVCD 251
>sp|P53033|AC14_CHICK ACTIVATOR 1 40 KD SUBUNIT (REPLICATION FACTOR C 40 KD SUBUNIT) (A1
40 KD SUBUNIT) (RF-C 40 KD SUBUNIT) (RFC40)
>gi|2134397|pir||I50704 replication factor C/activator 1
subunit - chicken >gi|527669|gb|AAA20552.1| (U12438)
replication factor C/activator 1 subunit [Gallus gallus]
Length = 359
Score = 116 bits (289), Expect = 4e-25
Identities = 71/216 (32%), Positives = 120/216 (54%), Gaps = 19/216 (8%)
Query: 3 EVPWVEKYRPRRLSEIINQEDAISKVKAWIEAWLHGNPPKKKALLLAGPPGSGKTTTVYA 62
E+PWVEKYRP +L E++ ED +S+++ + + GN P +++AGPPG+GKTT++
Sbjct: 40 ELPWVEKYRPLKLCEVVGNEDTVSRLEVFAK---EGNVPN---IIIAGPPGTGKTTSILC 93
Query: 63 LAREY-----NFEVIELNASDERTYD----KIARYVQAAYTMDILGKRRKIIFLDEADNI 113
LAR V+ELNAS++R D KI + Q T+ R KII LDEAD++
Sbjct: 94 LARALLGPALKDAVLELNASNDRGIDVVRNKIKMFAQQKVTLP--KGRHKIIILDEADSM 151
Query: 114 EPSGAPEIAKLID--RARNPIIMAANHYWEVPKEIRDRAELVEYKRLTQRDVINALVRIL 171
+ + ++ +A N ++ + I+ R ++ Y +LT ++ L++I+
Sbjct: 152 TDGAQQALRRTMEIYSKTTRFALACNASDKIIEPIQSRCAVLRYTKLTDSQILARLLKIV 211
Query: 172 KREGITVPKEVLVEIAKRASGDLRAAINDLQTVVAG 207
++E + + L I A GD+R A+N+LQ+ +G
Sbjct: 212 EKEDVPYTDDGLEAIIFTAQGDMRQALNNLQSTYSG 247
>gi|6324478 Subunit 4 of Replication Factor C; homologous to human RFC 40 kDa
subunit; Rfc4p [Saccharomyces cerevisiae]
>gi|730503|sp|P40339|RFC4_YEAST ACTIVATOR 1 37 KD
SUBUNIT (REPLICATION FACTOR C 37 KD SUBUNIT)
>gi|626874|pir||A53845 replication factor C chain RFC4
[validated] - yeast (Saccharomyces cerevisiae)
>gi|499704|gb|AAA34970.1| (L20502) 37 kDa subunit
[Saccharomyces cerevisiae] >gi|600464|emb|CAA58185.1|
(X83121) orf 00923 [Saccharomyces cerevisiae]
>gi|841468|gb|AAC49063.1| (U26030) Rfc4p [Saccharomyces
cerevisiae] >gi|1419942|emb|CAA99106.1| (Z74836) ORF
YOL094c [Saccharomyces cerevisiae]
Length = 323
Score = 116 bits (287), Expect = 7e-25
Identities = 70/214 (32%), Positives = 120/214 (55%), Gaps = 15/214 (7%)
Query: 3 EVPWVEKYRPRRLSEIINQEDAISKVKAWIEAWLHGNPPKKKALLLAGPPGSGKTTTVYA 62
++PWVEKYRP+ LS+I+ ++ I +++ + GN P ++++G PG GKTT+V+
Sbjct: 8 QLPWVEKYRPQVLSDIVGNKETIDRLQQIAK---DGNMPH---MIISGMPGIGKTTSVHC 61
Query: 63 LARE-----YNFEVIELNASDERTYDKIARYVQ--AAYTMDILGKRRKIIFLDEADNIEP 115
LA E Y V+ELNASD+R D + ++ A + + + KI+ LDEAD++
Sbjct: 62 LAHELLGRSYADGVLELNASDDRGIDVVRNQIKHFAQKKLHLPPGKHKIVILDEADSMTA 121
Query: 116 SGAPEIAKLIDRARNP--IIMAANHYWEVPKEIRDRAELVEYKRLTQRDVINALVRILKR 173
+ + ++ N A N ++ + ++ R ++ Y +L+ DV+ L++I+K
Sbjct: 122 GAQQALRRTMELYSNSTRFAFACNQSNKIIEPLQSRCAILRYSKLSDEDVLKRLLQIIKL 181
Query: 174 EGITVPKEVLVEIAKRASGDLRAAINDLQTVVAG 207
E + + L I A GD+R AIN+LQ+ VAG
Sbjct: 182 EDVKYTNDGLEAIIFTAEGDMRQAINNLQSTVAG 215
>gi|4506487 replication factor C (activator 1) 2 (40kD) [Homo sapiens]
>gi|11421447|ref|XP_004901.1| replication factor C
(activator 1) 2 (40kD) [Homo sapiens]
>gi|2507300|sp|P35250|AC14_HUMAN ACTIVATOR 1 40 KDA
SUBUNIT (REPLICATION FACTOR C 40 KDA SUBUNIT) (A1 40 KDA
SUBUNIT) (RF-C 40 KDA SUBUNIT) (RFC40)
>gi|1590811|gb|AAB09786.1| (M87338) replication factor
C, 40-kDa subunit [Homo sapiens]
>gi|2914760|gb|AAC04860.1| (AF045555) replication factor
C subunit 2 [Homo sapiens]
Length = 354
Score = 115 bits (286), Expect = 9e-25
Identities = 70/216 (32%), Positives = 119/216 (54%), Gaps = 19/216 (8%)
Query: 3 EVPWVEKYRPRRLSEIINQEDAISKVKAWIEAWLHGNPPKKKALLLAGPPGSGKTTTVYA 62
E+PWVEKYRP +L+EI+ ED +S+++ + GN P +++AGPPG+GKTT++
Sbjct: 35 ELPWVEKYRPVKLNEIVGNEDTVSRLEVFAR---EGNVPN---IIIAGPPGTGKTTSILC 88
Query: 63 LAREY-----NFEVIELNASDERTYD----KIARYVQAAYTMDILGKRRKIIFLDEADNI 113
LAR ++ELNAS++R D KI + Q T+ R KII LDEAD++
Sbjct: 89 LARALLGPALKDAMLELNASNDRGIDVVRNKIKMFAQQKVTLP--KGRHKIIILDEADSM 146
Query: 114 EPSGAPEIAKLID--RARNPIIMAANHYWEVPKEIRDRAELVEYKRLTQRDVINALVRIL 171
+ + ++ +A N ++ + I+ R ++ Y +LT ++ L+ ++
Sbjct: 147 TDGAQQALRRTMEIYSKTTRFALACNASDKIIEPIQSRCAVLRYTKLTDAQILTRLMNVI 206
Query: 172 KREGITVPKEVLVEIAKRASGDLRAAINDLQTVVAG 207
++E + + L I A GD+R A+N+LQ+ +G
Sbjct: 207 EKERVPYTDDGLEAIIFTAQGDMRQALNNLQSTFSG 242
>pir||A42700 replication factor C - human
Length = 353
Score = 115 bits (285), Expect = 1e-24
Identities = 70/215 (32%), Positives = 119/215 (54%), Gaps = 18/215 (8%)
Query: 3 EVPWVEKYRPRRLSEIINQEDAISKVKAWIEAWLHGNPPKKKALLLAGPPGSGKTTTVYA 62
E+PWVEKYRP +L+EI+ ED +S+++ + GN P +++AGPPG+GKTT++
Sbjct: 35 ELPWVEKYRPVKLNEIVGNEDTMSRLEVFAR---EGNVPN---IIIAGPPGTGKTTSILC 88
Query: 63 LAREY----NFEVIELNASDERTYD----KIARYVQAAYTMDILGKRRKIIFLDEADNIE 114
LAR ++ELNAS++R D KI + Q T+ R KII LDEAD++
Sbjct: 89 LARALLGALKDAMLELNASNDRGIDVVRNKIKMFAQQKVTLP--KGRHKIIILDEADSMT 146
Query: 115 PSGAPEIAKLID--RARNPIIMAANHYWEVPKEIRDRAELVEYKRLTQRDVINALVRILK 172
+ + ++ +A N ++ + I+ R ++ Y +LT ++ L+ +++
Sbjct: 147 DGAQQALRRTMEIYSKTTRFALACNASDKIIEPIQSRCAVLRYTKLTDAQILTRLMNVIE 206
Query: 173 REGITVPKEVLVEIAKRASGDLRAAINDLQTVVAG 207
+E + + L I A GD+R A+N+LQ+ +G
Sbjct: 207 KERVPYTDDGLEAIIFTAQGDMRQALNNLQSTFSG 241
>gi|11499642 activator 1, replication factor C, 35 KD subunit [Archaeoglobus
fulgidus] >gi|7444552|pir||C69507 activator 1,
replication factor C, 35 KD subunit homolog -
Archaeoglobus fulgidus >gi|2648471|gb|AAB89191.1|
(AE000961) activator 1, replication factor C, 35 KD
subunit [Archaeoglobus fulgidus]
Length = 319
Score = 113 bits (281), Expect = 3e-24
Identities = 72/211 (34%), Positives = 113/211 (53%), Gaps = 14/211 (6%)
Query: 6 WVEKYRPRRLSEIINQEDAISKVKAWIEAWLHGNPPKKKALLLAGPPGSGKTTTVYALAR 65
WVEKYRPR L E++ Q++ I ++K ++E N P LL +GPPG+GKT T ALAR
Sbjct: 7 WVEKYRPRTLDEVVGQDEVIQRLKGYVE---RKNIPH---LLFSGPPGTGKTATAIALAR 60
Query: 66 E-----YNFEVIELNASDERTYDKIARYV-QAAYTMDILGKRRKIIFLDEADNIEPSGAP 119
+ + IE+NASDER D + + + A T I G KIIFLDEAD +
Sbjct: 61 DLFGENWRDNFIEMNASDERGIDVVRHKIKEFARTAPIGGAPFKIIFLDEADALTADAQA 120
Query: 120 EIAKLIDRARNP--IIMAANHYWEVPKEIRDRAELVEYKRLTQRDVINALVRILKREGIT 177
+ + ++ I++ N+ + + I+ R + +K + + + L+ I ++EG+
Sbjct: 121 ALRRTMEMYSKSCRFILSCNYVSRIIEPIQSRCAVFRFKPVPKEAMKKRLLEICEKEGVK 180
Query: 178 VPKEVLVEIAKRASGDLRAAINDLQTVVAGG 208
+ ++ L + + GD R AIN LQ A G
Sbjct: 181 ITEDGLEALIYISGGDFRKAINALQGAAAIG 211
>pir||C72633 probable replication factor C subunit APE1522 - Aeropyrum pernix
(strain K1) >gi|5105207|dbj|BAA80521.1| (AP000061) 346aa
long hypothetical replication factor C subunit
[Aeropyrum pernix]
Length = 346
Score = 112 bits (278), Expect = 8e-24
Identities = 92/288 (31%), Positives = 146/288 (49%), Gaps = 26/288 (9%)
Query: 3 EVPWVEKYRPRRLSEIINQEDAISKVKAWIEAWLHGNPPKKKALLLAGPPGSGKTTTVYA 62
E+ WVEKYRPR L +I++Q+ + ++K +++ N P LL AGPPG+GKTT +A
Sbjct: 27 EMLWVEKYRPRSLDDIVDQKHVVERLKQFVK---QRNMPH---LLFAGPPGTGKTTAAHA 80
Query: 63 LARE-----YNFEVIELNASDERTY----DKIARYVQAAYTMDILGKRRKIIFLDEADNI 113
LA + Y ++ELNASDER +K+ + ++ +I KI+ LDEADN+
Sbjct: 81 LAHDLFGENYRQYMLELNASDERGINVIREKVKEFARSRTPPEI---PFKIVLLDEADNM 137
Query: 114 EPSGAPEIAKLID--RARNPIIMAANHYWEVPKEIRDRAELVEYKRLTQRDVINALVRIL 171
+ +L++ + I+ AN+ ++ I+ R ++ L+++DVI L I
Sbjct: 138 TSDAQQALRRLMELYSSVTRFILIANYPSKIIDPIQSRCAFFRFQPLSKQDVIERLRYIA 197
Query: 172 KREGITVPKEVLVEIAKRASGDLRAAINDLQTVVAGG--YEDARYVLAYRDVEKTVFQAL 229
+ EG+ +E L I + + GD+R AIN LQ G DA Y + + V + L
Sbjct: 198 ENEGVDYEEEALDAIYEISEGDMRKAINVLQAASYLGKVTVDAVYRVVGMAKPREVREML 257
Query: 230 GLVFASD-NAKRAKL--AMMNLDMSPDEFLLWIDENIPHMYLK-PEEM 273
D A R+ L M+ MS ++ I + LK PEE+
Sbjct: 258 ATALKGDFTAARSLLRKIMIEYGMSGEDVARQIHRELFSTELKMPEEL 305
>gb|AAK41065.1| Activator 1, replication factor C, small subunit (rfc) [Sulfolobus
solfataricus]
Length = 330
Score = 112 bits (277), Expect = 1e-23
Identities = 81/251 (32%), Positives = 122/251 (48%), Gaps = 24/251 (9%)
Query: 3 EVPWVEKYRPRRLSEIINQEDAISKVKAWIEAWLHGNPPKKKALLLAGPPGSGKTTTVYA 62
E+ W EKYRP+ L +I+NQ + I ++K +++ N P LL AGPPG+GKTT A
Sbjct: 7 EILWAEKYRPKTLDDIVNQREIIDRLKKFVK---EKNMPH---LLFAGPPGTGKTTAALA 60
Query: 63 LARE-----YNFEVIELNASDERTYDKIARYVQAAYTMDILGKRR-KIIFLDEADNIEPS 116
L + Y +ELNASDER D I V+ I G K++ LDEADN+
Sbjct: 61 LVHDLYGDNYTEYFLELNASDERGIDVIRNKVKEFARTVIPGDIPFKVVLLDEADNMTAD 120
Query: 117 GAPEIAKLID--RARNPIIMAANHYWEVPKEIRDRAELVEYKRLTQRDVINALVRILKRE 174
+ + ++ I+A N+ ++ + I+ R L + L + DV+N L+ I K E
Sbjct: 121 AQQALRRTMELYTENTRFILACNYLSKIIEPIQSRTALFRFYPLKKEDVVNRLIYIAKNE 180
Query: 175 GITVPKEVLVEIAKRASGDLRAAINDLQTVVAGGYEDARYVLAYRDVEKTVFQALGLVFA 234
++ L I GD+R +IN LQ A G + + VF+ LGL
Sbjct: 181 KAEYDQKALETIYDITMGDMRKSINILQAASAYG----------KISVEAVFKVLGLAQP 230
Query: 235 SDNAKRAKLAM 245
+ + LA+
Sbjct: 231 KEVREMINLAL 241
>sp|P53034|AC14_DROME ACTIVATOR 1 40 KDA SUBUNIT (REPLICATION FACTOR C 40 KDA SUBUNIT)
(A1 40 KDA SUBUNIT) (RF-C 40 KDA SUBUNIT) (RFC40)
>gi|2133712|pir||S55020 replication factor C 40K chain
homolog - fruit fly (Drosophila melanogaster)
>gi|639708|gb|AAB60241.1| (U15967) rfc40 [Drosophila
melanogaster] >gi|7292439|gb|AAF47843.1| (AE003480)
RfC40 gene product [Drosophila melanogaster]
Length = 331
Score = 112 bits (277), Expect = 1e-23
Identities = 68/215 (31%), Positives = 113/215 (51%), Gaps = 19/215 (8%)
Query: 4 VPWVEKYRPRRLSEIINQEDAISKVKAWIEAWLHGNPPKKKALLLAGPPGSGKTTTVYAL 63
+PW+EKYRP + EI+ ED ++++ + GN P +++AGPPG GKTTT+ L
Sbjct: 16 LPWIEKYRPVKFKEIVGNEDTVARLSVFAT---QGNAPN---IIIAGPPGVGKTTTIQCL 69
Query: 64 AR-----EYNFEVIELNASDERTYD----KIARYVQAAYTMDILGKRRKIIFLDEADNIE 114
AR Y V+ELNAS+ER D KI + Q T+ R KI+ LDEAD++
Sbjct: 70 ARILLGDSYKEAVLELNASNERGIDVVRNKIKMFAQQKVTLP--RGRHKIVILDEADSMT 127
Query: 115 PSGAPEIAKLID--RARNPIIMAANHYWEVPKEIRDRAELVEYKRLTQRDVINALVRILK 172
+ + ++ + +A N ++ + I+ R ++ + +L+ V+ L+ + K
Sbjct: 128 EGAQQALRRTMEIYSSTTRFALACNTSEKIIEPIQSRCAMLRFTKLSDAQVLAKLIEVAK 187
Query: 173 REGITVPKEVLVEIAKRASGDLRAAINDLQTVVAG 207
E + ++ L I A GD+R +N+LQ+ G
Sbjct: 188 WEKLNYTEDGLEAIVFTAQGDMRQGLNNLQSTAQG 222
>emb|CAB57535.1| (Y18930) activator 1, replication factor C, small subunit
[Sulfolobus solfataricus]
Length = 330
Score = 112 bits (277), Expect = 1e-23
Identities = 81/251 (32%), Positives = 122/251 (48%), Gaps = 24/251 (9%)
Query: 3 EVPWVEKYRPRRLSEIINQEDAISKVKAWIEAWLHGNPPKKKALLLAGPPGSGKTTTVYA 62
E+ W EKYRP+ L +I+NQ + I ++K +++ N P LL AGPPG+GKTT A
Sbjct: 7 EILWAEKYRPKTLDDIVNQREIIDRLKKFVK---EKNMPH---LLFAGPPGTGKTTAALA 60
Query: 63 LARE-----YNFEVIELNASDERTYDKIARYVQAAYTMDILGKRR-KIIFLDEADNIEPS 116
L + Y +ELNASDER D I V+ I G K++ LDEADN+
Sbjct: 61 LVHDLYGDNYTEYFLELNASDERGIDVIRNKVKEFARTVIPGDIPFKVVLLDEADNMTAD 120
Query: 117 GAPEIAKLID--RARNPIIMAANHYWEVPKEIRDRAELVEYKRLTQRDVINALVRILKRE 174
+ + ++ I+A N+ ++ + I+ R L + L + DV+N L+ I K E
Sbjct: 121 AQQALRRTMELYTENTRFILACNYLSKIIEPIQSRTALFRFYPLKKEDVVNRLIYIAKNE 180
Query: 175 GITVPKEVLVEIAKRASGDLRAAINDLQTVVAGGYEDARYVLAYRDVEKTVFQALGLVFA 234
++ L I GD+R +IN LQ A G + + VF+ LGL
Sbjct: 181 KAEYDQKALETIYDITMGDMRKSINILQAASAYG----------KISVEAVFKVLGLAQP 230
Query: 235 SDNAKRAKLAM 245
+ + LA+
Sbjct: 231 KEVREMINLAL 241
>emb|CAA07618.1| (AJ007712) replication factor C subunit [Arxula adeninivorans]
Length = 338
Score = 109 bits (269), Expect = 9e-23
Identities = 67/211 (31%), Positives = 110/211 (51%), Gaps = 14/211 (6%)
Query: 4 VPWVEKYRPRRLSEIINQEDAISKVKAWIEAWLHGNPPKKKALLLAGPPGSGKTTTVYAL 63
+PWVEKYRP L E+ E I+ +K ++E G P LL GPPG+GKTTT+ A+
Sbjct: 17 LPWVEKYRPTTLDEVAGHEGVITTIKKFVE---EGKLPH---LLFHGPPGTGKTTTIIAV 70
Query: 64 ARE-----YNFEVIELNASDERTYDKIARYVQA-AYTMDILGKRRKIIFLDEADNIEPSG 117
AR+ Y ++ELNASDER D + ++ A T I K++ LDEAD + +
Sbjct: 71 ARQIYGKNYRNMILELNASDERGIDVVRDQIKTFASTRQIFSSGFKLVILDEADAMTNAA 130
Query: 118 APEIAKLIDR--ARNPIIMAANHYWEVPKEIRDRAELVEYKRLTQRDVINALVRILKREG 175
+ ++I++ A + AN+ ++ + R + L + + + L ++++E
Sbjct: 131 QNALRRIIEKYSAHTRFCILANYTHKLNPALLSRCTRFRFSPLKEDAIKHRLAHVIEQES 190
Query: 176 ITVPKEVLVEIAKRASGDLRAAINDLQTVVA 206
+ + E + +SGD+R A+N LQ A
Sbjct: 191 VDLSPEAFQSLLHLSSGDMRRALNVLQACYA 221
>gb|AAB88360.1| (AF036699) strong similarity to the activator 1 36 to 40 KD
subunits family of DNA replication factors
[Caenorhabditis elegans]
Length = 334
Score = 108 bits (267), Expect = 1e-22
Identities = 72/210 (34%), Positives = 113/210 (53%), Gaps = 15/210 (7%)
Query: 5 PWVEKYRPRRLSEIINQEDAISKVKAWIEAWLHGNPPKKKALLLAGPPGSGKTTTVYALA 64
PWVEKYRP+ L++I+ E+ + ++K GN P ++L+GPPG GKTT+V+ALA
Sbjct: 11 PWVEKYRPKVLADIVGNENIVERLKV---IGHEGNVPN---IVLSGPPGCGKTTSVWALA 64
Query: 65 REYNFE-----VIELNASDERTYDKIARYVQA-AYTMDILGK-RRKIIFLDEADNIEPSG 117
RE + V+ELNASDER D + ++ A T L + R KII LDEAD++
Sbjct: 65 RELLGDKVKEAVLELNASDERGIDVVRHRIKTFAQTKVTLPEGRHKIIILDEADSMTDGA 124
Query: 118 APEIAKLIDRARNP--IIMAANHYWEVPKEIRDRAELVEYKRLTQRDVINALVRILKREG 175
+ + ++ +A N ++ + I+ R L+ Y +L+ ++ + + K E
Sbjct: 125 QQALRRTMEMYTKTTRFALACNQSEKIIEPIQSRCALLRYTKLSPVQLLTRVKEVAKAEK 184
Query: 176 ITVPKEVLVEIAKRASGDLRAAINDLQTVV 205
+ L I A GD+R A+N+LQ V
Sbjct: 185 VNYDDGGLEAILFTAQGDMRQALNNLQATV 214
>pir||B69130 replication factor C, small subunit - Methanobacterium
thermoautotrophicum (strain Delta H)
>gi|2621290|gb|AAB84747.1| (AE000811) replication factor
C, small subunit [Methanobacterium thermoautotrophicum]
Length = 321
Score = 106 bits (262), Expect = 6e-22
Identities = 85/308 (27%), Positives = 137/308 (43%), Gaps = 34/308 (11%)
Query: 5 PWVEKYRPRRLSEIINQEDAISKVKAWIEAWLHGNPPKKKALLLAGPPGSGKTTTVYALA 64
PWVEKYRP++L +I+ QE I ++K ++E N L+ GP G GKTT ALA
Sbjct: 7 PWVEKYRPQKLDDIVGQEHIIPRLKRYVEEKSMPN------LMFTGPAGVGKTTAALALA 60
Query: 65 RE-----YNFEVIELNASDERTYDKIARYVQAAYTMDILGKRRKIIFLDEADNIEPSGAP 119
RE + +ELNASD R D + ++ + +G +IIFLDE DN+
Sbjct: 61 REILGEYWRQNFLELNASDARGIDTVRTSIKNFCRLKPVGAPFRIIFLDEVDNMTKDAQH 120
Query: 120 EIAKLID--RARNPIIMAANHYWEVPKEIRDRAELVEYKRLTQRDVINALVRILKREGIT 177
+ + ++ + I++ N+ ++ I+ R + + L +I L I ++E +
Sbjct: 121 ALRREMEMYTKTSSFILSCNYSSKIIDPIQSRCAIFRFLPLKGHQIIKRLEYIAEKENLE 180
Query: 178 VPKEVLVEIAKRASGDLRAAINDLQTVVAGGYEDARYVLAYRDVEKTVFQALGLVFASDN 237
L I A GDLR AIN LQ+ + L + E +++ + D
Sbjct: 181 YEAHALETIVYFAEGDLRKAINLLQSAAS---------LGEKITESSIYDVVSRARPKDV 231
Query: 238 AKRAKLAMMNLDMSPDEFLLWI--------DENIPHMYLKPEEMAR-AYEAISKADIYLG 288
K K + M + L I ++ + +Y +E++R A E D Y+G
Sbjct: 232 RKMIKTILDGKFMEARDMLREIMVLQGISGEDMVTQIY---QELSRLAMEGEVDGDRYVG 288
Query: 289 RAQRTGNY 296
G Y
Sbjct: 289 LIDAIGEY 296
>gi|6324039 Subunit 3 of Replication Factor C; homologous to human RFC 36 kDa
subunit; Rfc3p [Saccharomyces cerevisiae]
>gi|585844|sp|P38629|RFC3_YEAST ACTIVATOR 1 40 KD
SUBUNIT (REPLICATION FACTOR C 40 KD SUBUNIT)
>gi|1078326|pir||A36988 replication factor C chain RFC3
[validated] - yeast (Saccharomyces cerevisiae)
>gi|439118|gb|AAA34969.1| (L18755) replication factor C
[Saccharomyces cerevisiae] >gi|841466|gb|AAC49062.1|
(U26029) Rfc3p [Saccharomyces cerevisiae]
>gi|1050872|gb|AAC49110.1| (U23084) replication factor
C, 40 kDa subunit [Saccharomyces cerevisiae]
>gi|1302375|emb|CAA96207.1| (Z71566) ORF YNL290w
[Saccharomyces cerevisiae]
Length = 340
Score = 104 bits (257), Expect = 2e-21
Identities = 67/211 (31%), Positives = 110/211 (51%), Gaps = 14/211 (6%)
Query: 4 VPWVEKYRPRRLSEIINQEDAISKVKAWIEAWLHGNPPKKKALLLAGPPGSGKTTTVYAL 63
+PWVEKYRP L E+ Q + I+ V+ +++ G P LL GPPG+GKT+T+ AL
Sbjct: 13 LPWVEKYRPETLDEVYGQNEVITTVRKFVD---EGKLPH---LLFYGPPGTGKTSTIVAL 66
Query: 64 ARE-----YNFEVIELNASDERTYDKIARYVQ-AAYTMDILGKRRKIIFLDEADNIEPSG 117
ARE Y+ V+ELNASD+R D + ++ A T I K K+I LDEAD + +
Sbjct: 67 AREIYGKNYSNMVLELNASDDRGIDVVRNQIKDFASTRQIFSKGFKLIILDEADAMTNAA 126
Query: 118 APEIAKLIDR--ARNPIIMAANHYWEVPKEIRDRAELVEYKRLTQRDVINALVRILKREG 175
+ ++I+R + AN+ ++ + R ++ L Q + + +L E
Sbjct: 127 QNALRRVIERYTKNTRFCVLANYAHKLTPALLSRCTRFRFQPLPQEAIERRIANVLVHEK 186
Query: 176 ITVPKEVLVEIAKRASGDLRAAINDLQTVVA 206
+ + + + ++GD+R +N LQ+ A
Sbjct: 187 LKLSPNAEKALIELSNGDMRRVLNVLQSCKA 217
>gi|6677723 replication factor C (activator 1) 5 (36.5kD) [Homo sapiens]
>gi|728777|sp|P40937|AC11_HUMAN ACTIVATOR 1 36 KDA
SUBUNIT (REPLICATION FACTOR C 36 KDA SUBUNIT) (A1 36 KDA
SUBUNIT) (RF-C 36 KDA SUBUNIT) (RFC36)
>gi|1498257|gb|AAB09784.1| (L07540) replication factor
C, 36-kDa subunit [Homo sapiens]
Length = 340
Score = 103 bits (255), Expect = 4e-21
Identities = 73/245 (29%), Positives = 126/245 (50%), Gaps = 26/245 (10%)
Query: 4 VPWVEKYRPRRLSEIINQEDAISKVKAWIEAWLHGNPPKKKALLLAGPPGSGKTTTVYAL 63
+PWVEKYRP+ L+++I+ +D +S ++ +I N + LLL GPPG+GKT+T+ A
Sbjct: 20 LPWVEKYRPQTLNDLISHQDILSTIQKFI------NEDRLPHLLLYGPPGTGKTSTILAC 73
Query: 64 A------REYNFEVIELNASDERTYDKI-ARYVQAAYTMDILGKRRKIIFLDEADNIEPS 116
A +E+ V+ELNASD+R D I + A T I K K++ LDEAD +
Sbjct: 74 AKQLYKDKEFGSMVLELNASDDRGIDIIRGPILSFASTRTIFKKGFKLVILDEADAMTQD 133
Query: 117 GAPEIAKLIDR--ARNPIIMAANHYWEVPKEIRDRAELVEYKRLTQRDVINALVRILKRE 174
+ ++I++ + N+ ++ ++ R + LT ++ L +++ E
Sbjct: 134 AQNALRRVIEKFTENTRFCLICNYLSKIIPALQSRCTRFRFGPLTPELMVPRLEHVVEEE 193
Query: 175 GITVPKEVLVEIAKRASGDLRAAINDLQ-TVVAGGYEDARYVLAYRDVEKTVFQALGLVF 233
+ + ++ + + +SGD+R A+N LQ T +A G + E+TV+ G
Sbjct: 194 KVDISEDGMKALVTLSSGDMRRALNILQSTNMAFG----------KVTEETVYTCTGHPL 243
Query: 234 ASDNA 238
SD A
Sbjct: 244 KSDIA 248
>gi|4506491 replication factor C (activator 1) 4 (37kD) [Homo sapiens]
>gi|11435044|ref|XP_003190.1| replication factor C
(activator 1) 4 (37kD) [Homo sapiens]
>gi|1703052|sp|P35249|AC12_HUMAN ACTIVATOR 1 37 KD
SUBUNIT (REPLICATION FACTOR C 37 KD SUBUNIT) (A1 37 KD
SUBUNIT) (RF-C 37 KD SUBUNIT) (RFC37)
>gi|1498256|gb|AAB09785.1| (M87339) replication factor
C, 37-kDa subunit [Homo sapiens]
Length = 363
Score = 103 bits (255), Expect = 4e-21
Identities = 71/231 (30%), Positives = 114/231 (48%), Gaps = 24/231 (10%)
Query: 4 VPWVEKYRPRRLSEIINQEDAISKVKAWIEAWLHGNPPKKKALLLAGPPGSGKTTTVYAL 63
VPWVEKYRP+ + E+ QE+ ++ +K +E N LL GPPG+GKT+T+ A
Sbjct: 38 VPWVEKYRPKCVDEVAFQEEVVAVLKKSLEGADLPN------LLFYGPPGTGKTSTILAA 91
Query: 64 ARE------YNFEVIELNASDERTYDKIARYVQAAYTMDILGKRR--------KIIFLDE 109
ARE + V+ELNASDER + V+ + + G R KI+ LDE
Sbjct: 92 ARELFGPELFRLRVLELNASDERGIQVVREKVKNFAQLTVSGSRSDGKPCPPFKIVILDE 151
Query: 110 ADNIEPSGAPEIAKLIDRARNP--IIMAANHYWEVPKEIRDRAELVEYKRLTQRDVINAL 167
AD++ + + + +++ + N+ + + + R +K L+ + L
Sbjct: 152 ADSMTSAAQAALRRTMEKESKTTRFCLICNYVSRIIEPLTSRCSKFRFKPLSDKIQQQRL 211
Query: 168 VRILKREGITVPKEVLVEIAKRASGDLRAAINDLQ--TVVAGGYEDARYVL 216
+ I K+E + + E + + K + GDLR AI LQ T + GG E V+
Sbjct: 212 LDIAKKENVKISDEGIAYLVKVSEGDLRKAITFLQSATRLTGGKEITEKVI 262
>pir||A45253 activator 1 37K chain - human
Length = 363
Score = 102 bits (252), Expect = 8e-21
Identities = 70/233 (30%), Positives = 114/233 (48%), Gaps = 24/233 (10%)
Query: 4 VPWVEKYRPRRLSEIINQEDAISKVKAWIEAWLHGNPPKKKALLLAGPPGSGKTTTVYAL 63
VPWVEKYRP+ + E+ QE+ ++ +K +E N LL GPPG+GKT+T+ A
Sbjct: 38 VPWVEKYRPKCVDEVAFQEEVVAVLKKSLEGADLPN------LLFYGPPGTGKTSTILAA 91
Query: 64 ARE------YNFEVIELNASDERTYDKIARYVQAAYTMDILGKRR--------KIIFLDE 109
ARE + V+ELNASDER + V+ + + G R KI+ LDE
Sbjct: 92 ARELFGPELFRLRVLELNASDERGIQVVREKVKNFAQLTVSGSRSDGKPCPPFKIVILDE 151
Query: 110 ADNIEPSGAPEIAKLIDRARNP--IIMAANHYWEVPKEIRDRAELVEYKRLTQRDVINAL 167
AD++ + + + +++ + N+ + + + R +K L+ + L
Sbjct: 152 ADSMTSAAQAALRRTMEKESKTTRFCLICNYVSRIIEPLTSRCSKFRFKPLSDKIQQQRL 211
Query: 168 VRILKREGITVPKEVLVEIAKRASGDLRAAINDLQ--TVVAGGYEDARYVLAY 218
+ I K+E + + + + K + GDLR AI LQ T + GG E V+ +
Sbjct: 212 LDIAKKENVPISHRGIAYLVKVSEGDLRKAITFLQSATRLTGGKEITEKVITH 264
>gb|AAG20394.1| (AE005112) replication factor C small subunit; RfcA [Halobacterium
sp. NRC-1]
Length = 322
Score = 99.5 bits (244), Expect = 7e-20
Identities = 75/293 (25%), Positives = 137/293 (46%), Gaps = 21/293 (7%)
Query: 6 WVEKYRPRRLSEIINQEDAISKVKAWIEAWLHGNPPKKKALLLAGPPGSGKTTTVYALAR 65
WVEKYRP RL +++ D +++++++ LL AGP G+GKT + ++A+
Sbjct: 12 WVEKYRPERLEDVVGHPDITERLQSYVDR------DDLPHLLFAGPAGTGKTASSVSIAK 65
Query: 66 E-----YNFEVIELNASDERTYDKIARYVQAAYTMDILGKRRKIIFLDEADNIEPSGAPE 120
E + +ELNASDER D + ++ G ++IFLDEAD +
Sbjct: 66 ELYGDDWQDNFLELNASDERGIDVVRDRIKDFARSSFGGHNYRVIFLDEADALTDDAQSA 125
Query: 121 IAKLIDRARN--PIIMAANHYWEVPKEIRDRAELVEYKRLTQRDVINALVRILKREGITV 178
+ + +++ N I++ N+ ++ I+ R + + +L V L I + EG+
Sbjct: 126 LRRTMEQFSNNTRFILSCNYSSKIIDPIQSRCAVFRFAQLGDDAVAAHLREIAETEGLEH 185
Query: 179 PKEVLVEIAKRASGDLRAAINDLQTVVAGG---YEDARYVLAY----RDVEKTVFQALGL 231
+ + + A GD+R AIN LQ A G E+ Y + ++E V +ALG
Sbjct: 186 TDDGIDALVYAADGDMRRAINALQAASATGDSVNEETVYAITATARPEEIETMVTEALGG 245
Query: 232 VFASDNAKRAKLAMMNLDMSPDEFLLWIDENIPHMYLKPEEMARAYEAISKAD 284
FA+ A L + N ++ + + + ++ ++ R + + +AD
Sbjct: 246 DFAAARATLDDL-LTNRGLAGGDIIDQVHRSVWEFDVEEAAAVRLLDRLGEAD 297
>pir||D71603 replication factor C, 140 kDa subunit (ATPase) PFB0895c - malaria
parasite (Plasmodium falciparum)
>gi|3845304|gb|AAC71968.1| (AE001423) replication factor
C, 140 kDa subunit (ATPase) [Plasmodium falciparum]
Length = 904
Score = 99.1 bits (243), Expect = 1e-19
Identities = 66/224 (29%), Positives = 110/224 (48%), Gaps = 27/224 (12%)
Query: 6 WVEKYRPRRLSEIINQEDAISKVKAWIEAW----LHG--NPPKK-----------KALLL 48
WVEKYRP+ L+E++ + K++ W+ +W + G P +K + LL
Sbjct: 353 WVEKYRPKNLNELVGNNQNVIKLQNWLASWEDVCIKGIKKPAQKTFRGIFENVNARCALL 412
Query: 49 AGPPGSGKTTTVYALAREYNFEVIELNASDER---TYDKIARYVQAAYTMDILGKR---R 102
+GP G GKTTT ++ + VIE NASDER +KI+ Y++ L R +
Sbjct: 413 SGPAGIGKTTTAKIVSEASGYNVIEFNASDERNKAAVEKISEMATGGYSIMSLNNRKLTK 472
Query: 103 KIIFLDEADNI---EPSGAPEIAKLIDRARNPIIMAAN-HYWEVPKEIRDRAELVEYKRL 158
I +DE D + + G+ I KLI++ + PII N + + ++ +++
Sbjct: 473 TCIIMDEVDGMSSGDKGGSTAILKLIEKTKCPIICICNDRQNNKMRTLANKCYDLKFSMP 532
Query: 159 TQRDVINALVRILKREGITVPKEVLVEIAKRASGDLRAAINDLQ 202
+ V+ L+ I K+EGI + L + + GD+R +N LQ
Sbjct: 533 QKNSVVKRLLEICKKEGIMMEPNALELLWESTCGDIRQMLNTLQ 576
>pir||T43410 replication factor C chain Rfc3 - fission yeast
(Schizosaccharomyces pombe) >gi|4468733|emb|CAB38106.1|
(AJ012839) replication factor C subunit
[Schizosaccharomyces pombe] >gi|5688939|dbj|BAA82745.1|
(AB017039) Rfc3 [Schizosaccharomyces pombe]
>gi|5688941|dbj|BAA82746.1| (AB017040) Rfc3
[Schizosaccharomyces pombe]
Length = 342
Score = 99.1 bits (243), Expect = 1e-19
Identities = 57/207 (27%), Positives = 111/207 (53%), Gaps = 14/207 (6%)
Query: 4 VPWVEKYRPRRLSEIINQEDAISKVKAWIEAWLHGNPPKKKALLLAGPPGSGKTTTVYAL 63
+PWVEKYRP L ++++ +D IS ++ +I + + +L GPPG+GKT+T+ A
Sbjct: 23 LPWVEKYRPANLEDVVSHKDIISTLEKFISS------NRVPHMLFYGPPGTGKTSTILAC 76
Query: 64 ARE-----YNFEVIELNASDERTYDKIARYVQ-AAYTMDILGKRRKIIFLDEADNIEPSG 117
AR+ Y +++ELNASD+R D + ++ A T I K+I LDEAD + +
Sbjct: 77 ARKIYGPNYRNQLMELNASDDRGIDAVREQIKNFASTRQIFASTFKMIILDEADAMTLAA 136
Query: 118 APEIAKLIDRARNPI--IMAANHYWEVPKEIRDRAELVEYKRLTQRDVINALVRILKREG 175
+ ++I++ + + N+ ++ I+ R ++ L +++ + +++ E
Sbjct: 137 QNALRRVIEKYTKNVRFCIICNYINKISPAIQSRCTRFRFQPLPPKEIEKTVDHVIQSEH 196
Query: 176 ITVPKEVLVEIAKRASGDLRAAINDLQ 202
+ + + + + + GD+R A+N LQ
Sbjct: 197 CNIDPDAKMAVLRLSKGDMRKALNILQ 223
>emb|CAC12618.1| (AL445067) probable replication factor C, 40 KD subunit
[Thermoplasma acidophilum]
Length = 330
Score = 97.5 bits (239), Expect = 3e-19
Identities = 85/331 (25%), Positives = 157/331 (46%), Gaps = 39/331 (11%)
Query: 6 WVEKYRPRRLSEIINQEDAISKVKAWIEAWLHGNPPKKKA--LLLAGPPGSGKTTTVYAL 63
W EKYRP+ LSEI +++ I K+K+++E KK+ LL AG G+GKT+T AL
Sbjct: 17 WTEKYRPKSLSEIYGEDENIQKLKSFVE--------KKEIPHLLFAGSVGTGKTSTAIAL 68
Query: 64 ARE-----YNFEVIELNASDERTYDKIARYVQAAYTM---DILGKRRKIIFLDEADNIEP 115
A E + ++E+NAS+E D I ++ + + LG KI+FLDEAD +
Sbjct: 69 AIELFGDSWKENMVEMNASNENGIDVIRNKIKDIARIKPSNPLGF--KILFLDEADQLTA 126
Query: 116 SGAPEIAKLID--RARNPIIMAANHYWEVPKEIRDRAELVEYKRLTQRDVINALVRILKR 173
+ + ++ I + N+ ++ I+ R ++ ++ + + L I K
Sbjct: 127 EAQAALRRTMEIYSETTRFIFSCNYSSKIIPPIQSRTVVMRFRPVPDEYISRKLQEIAKN 186
Query: 174 EGITVPKEVLVEIAKRASGDLRAAINDLQTVVAGG-------YEDARYVLAYRDVEKTVF 226
EG + +E + + + ++GD+R AIN LQ V G YE Y + ++K +
Sbjct: 187 EGFQIDEESMHALVEVSAGDMRKAINVLQAVYTSGEISPKKIYEIIGYA-SPEKIQKMIS 245
Query: 227 QALGLVFASDNAKRAKLAMMNLD-MSPDEFLLWIDENIPHMYLKPEEMARAYEAISKADI 285
+A+ +F D A+ M+ D +S + + + + + P++ +A++ A+
Sbjct: 246 RAINGLF--DEAREIVDGMLIYDGLSGIDIVRSLHSYVRSSMISPKQKIEIIKALADAEF 303
Query: 286 YLGRAQRTGNYSLWRYAIDMMTAGVAVAGTK 316
+ R +D + A +A G++
Sbjct: 304 RIVEGSND------RIQLDALIAKLAEIGSR 328
>dbj|BAB16439.1| (AB038319) replication factor C 36kDa subunit [Oryza sativa]
Length = 367
Score = 96.3 bits (236), Expect = 6e-19
Identities = 63/210 (30%), Positives = 107/210 (50%), Gaps = 17/210 (8%)
Query: 5 PWVEKYRPRRLSEIINQEDAISKVKAWIEAWLHGNPPKKKALLLAGPPGSGKTTTVYALA 64
PWVEKYRP+ L ++ D + + N + LLL GPPG+GKT+T+ A+A
Sbjct: 39 PWVEKYRPQSLGDVAAHRDIVDTIDRLT------NENRLPHLLLYGPPGTGKTSTILAVA 92
Query: 65 R-----EYNFEVIELNASDERTYDKIARYVQ---AAYTMDILGKRR-KIIFLDEADNIEP 115
R +Y ++ELNASDER D + + +Q +A ++ K+ K++ LDEAD +
Sbjct: 93 RKLYGSQYGNMILELNASDERGIDVVRQQIQDFASARSLSFGAKQSVKMVLLDEADAMTK 152
Query: 116 SGAPEIAKLIDR--ARNPIIMAANHYWEVPKEIRDRAELVEYKRLTQRDVINALVRILKR 173
+ ++I++ + NH ++ ++ R + L V L I++
Sbjct: 153 DAQFALRRVIEKHTRSTRFALICNHVNKIIPALQSRCTRFRFAPLDGTHVRERLKHIIQS 212
Query: 174 EGITVPKEVLVEIAKRASGDLRAAINDLQT 203
EG+ V L + + ++GD+R A+N LQ+
Sbjct: 213 EGLDVDDGGLTALVRLSNGDMRKALNILQS 242
>pir||H71604 replication factor C, 40 kDa subunit (replication activator)
PFB0840w - malaria parasite (Plasmodium falciparum)
>gi|3845290|gb|AAC71957.1| (AE001420) replication factor
C, 40 kDa subunit (replication activator) [Plasmodium
falciparum]
Length = 330
Score = 96.0 bits (235), Expect = 8e-19
Identities = 66/222 (29%), Positives = 110/222 (48%), Gaps = 27/222 (12%)
Query: 1 MPEVPWVEKYRPRRLSEIINQEDAISKVKAWIEAWLHGNPPKKKALLLAGPPGSGKTTTV 60
M +PWVEKYRP+RL +I++Q +A+ +K + N P L+ GPPG+GKT+ +
Sbjct: 1 MENIPWVEKYRPKRLDDIVHQNNAVMMLKEVVRT---KNMPH---LIFHGPPGTGKTSAI 54
Query: 61 YALARE------YNFEVIELNASDERTYDKIARYVQAAYTMDILGKRR------------ 102
ALA E + V+ELNASD+R + + ++ AYT + K +
Sbjct: 55 NALAHELFGKENISERVLELNASDDRGINVVREKIK-AYTRISISKNKIHSETKEVLPSW 113
Query: 103 KIIFLDEADNIEPSGAPEIAKLIDRARN--PIIMAANHYWEVPKEIRDRAELVEYKRLTQ 160
K++ LDEAD + + ++I+ N I+ N+ ++ I R ++ +
Sbjct: 114 KLVVLDEADMMTEDAQSALRRIIEIYSNVTRFILICNYIHKISDPIFSRCSCYRFQSIPI 173
Query: 161 RDVINALVRILKREGITVPKEVLVEIAKRASGDLRAAINDLQ 202
L+ I + E I + + L +I + GDLR A++ LQ
Sbjct: 174 NIKKEKLLYICQNENIDIVDDALEKIIETTEGDLRRAVSILQ 215
>gb|AAG37987.1|AF071409_1 (AF071409) replication factor C subunit 2; RFC2 [Plasmodium
falciparum]
Length = 330
Score = 96.0 bits (235), Expect = 8e-19
Identities = 66/222 (29%), Positives = 110/222 (48%), Gaps = 27/222 (12%)
Query: 1 MPEVPWVEKYRPRRLSEIINQEDAISKVKAWIEAWLHGNPPKKKALLLAGPPGSGKTTTV 60
M +PWVEKYRP+RL +I++Q +A+ +K + N P L+ GPPG+GKT+ +
Sbjct: 1 MENIPWVEKYRPKRLDDIVHQNNAVMMLKEVVRT---KNMPH---LIFHGPPGTGKTSAI 54
Query: 61 YALARE------YNFEVIELNASDERTYDKIARYVQAAYTMDILGKRR------------ 102
ALA E + V+ELNASD+R + + ++ AYT + K +
Sbjct: 55 NALAHELFGKENISERVLELNASDDRGINVVREKIK-AYTRISISKNKIHSETKEVLPSW 113
Query: 103 KIIFLDEADNIEPSGAPEIAKLIDRARN--PIIMAANHYWEVPKEIRDRAELVEYKRLTQ 160
K++ LDEAD + + ++I+ N I+ N+ ++ I R ++ +
Sbjct: 114 KLVVLDEADMMTEDAQSALRRIIEIYSNVTRFILICNYIHKISDPIFSRCSCYRFQSIPI 173
Query: 161 RDVINALVRILKREGITVPKEVLVEIAKRASGDLRAAINDLQ 202
L+ I + E I + + L +I + GDLR A++ LQ
Sbjct: 174 NIKKEKLLYICQNENIDIVDDALEKIIETTEGDLRRAVSILQ 215
>pir||A49393 activator 1 large chain - mouse >gi|405112|gb|AAA21643.1| (U01222)
murine A1-p145 [Mus musculus]
Length = 1131
Score = 94.8 bits (232), Expect = 2e-18
Identities = 132/571 (23%), Positives = 238/571 (41%), Gaps = 120/571 (21%)
Query: 6 WVEKYRPRRLSEIINQE---DAISKVKAWIEAWLHGNPPKKK------------------ 44
WV+KY+P L II Q+ +K+ W+ W +P +KK
Sbjct: 570 WVDKYKPASLKNIIGQQGDQSCANKLLRWLRNWHKSSPEEKKHAAKFGKLASKDDGSSFK 629
Query: 45 ALLLAGPPGSGKTTTVYALAREYNFEVIELNASDERTYDKIARYV-QAAYTMDILG---- 99
A LL+GPPG GKTTT + +E + +ELNASD R+ + + V ++ I G
Sbjct: 630 AALLSGPPGVGKTTTASLVCQELGYSYVELNASDTRSKNSLKAVVAESLNNTSIKGFYTS 689
Query: 100 ------KRRKIIFLDEAD----NIEPSGAPEIAKLIDRARNPIIMAANHYWEVPKEIRDR 149
R + +DE D N + G E+ LI + PII N PK IR
Sbjct: 690 GAAPSVSARHALIMDEVDGMAGNEDRGGIQELIGLIKHTKIPIICMCNDR-NHPK-IRSL 747
Query: 150 AEL---VEYKRLTQRDVINALVRILKREGITVPKEVLVEIAKRASGDLRAAINDLQTVVA 206
+ ++R + +A++ I +EG+ +P + EI A+ D+R +++L A
Sbjct: 748 VHYCFDLRFQRPRVEQIKSAMLSIAFKEGLKIPPPAMNEIILGANQDVRQVLHNLSMWCA 807
Query: 207 GG----YEDAR--YVLAYRDVEKTVFQALGLVFASDNAKRAKLAMMNLDMSPDEFL---- 256
Y+ A+ A +D+ F VFA+ + A M+L D F
Sbjct: 808 QSKALTYDQAKADSQRAKKDIRLGPFDVTRKVFAAGE----ETAHMSLMDKSDLFFHDYS 863
Query: 257 ---LWIDENIPHMYLKPEE-----------MARAYEAISKADIYLGRAQRTGNYSLWRYA 302
L++ EN ++++KP ++RA ++I D+ + + N+SL
Sbjct: 864 IAPLFVQEN--YLHVKPVAAGGDMKKHLMLLSRAADSICDGDLVDNQIRSKQNWSL--LP 919
Query: 303 IDMMTAGVAVAGTKKRGFAKFYP--PNTL-KMLAESKEER-------------------- 339
+ A V + G RG+ +P PN L K + K +R
Sbjct: 920 TQAIYASV-LPGELMRGYMTQFPSFPNWLGKHSSTGKHDRIVQDLSLHMSLRTYSSKRTV 978
Query: 340 ------STRNSIIKKIMSE-----MHMSKLEAIETMKIIKTIFEKNLDLAAHFTVFLGLS 388
R+++++ + S+ H+ KL ++T ++K FE +++++ S
Sbjct: 979 NMDYLSHIRDALVRPLTSQGVEGAQHVIKL--MDTYYLMKEDFENIMEVSSWGGKPSAFS 1036
Query: 389 EKEVEFLA------GRENAGTIWGKALAIRRKLKKEEEKIRKERKEEEKVEVREEKPEEK 442
+ + + A +E T + + +L + +E ++ + + EK ++
Sbjct: 1037 KLDPKVKAAFTRAYNKEAHLTPYSLQVVKTSRLSTGPALDSEYSEEFQEDDTQSEKEQDA 1096
Query: 443 VEE----KREERETKKEKEKKEEKKAEKKGK 469
VE K++ R +K K ++E++ + KGK
Sbjct: 1097 VETDAMIKKKTRSSKPSKSEREKESKKGKGK 1127
>gb|AAF63387.1|AF247499_1 (AF247499) replication factor C subunit 3 [Drosophila melanogaster]
Length = 332
Score = 93.6 bits (229), Expect = 4e-18
Identities = 61/211 (28%), Positives = 110/211 (51%), Gaps = 15/211 (7%)
Query: 4 VPWVEKYRPRRLSEIINQEDAISKVKAWIEAWLHGNPPKKKALLLAGPPGSGKTTTVYAL 63
+PWVEKYRP L ++I+ E+ IS + +I + + LL GPPG+GKT+T+ A
Sbjct: 11 MPWVEKYRPSGLDDLISHEEIISTITRFI------SRKQLPHLLFYGPPGTGKTSTILAC 64
Query: 64 AR------EYNFEVIELNASDERTYDKI-ARYVQAAYTMDILGKRRKIIFLDEADNIEPS 116
AR ++ V+ELNASD+R + + + A T I K+I LDEAD +
Sbjct: 65 ARQLYSPQQFKSMVLELNASDDRGIGIVRGQILNFASTRTIFCDTFKLIILDEADAMTND 124
Query: 117 GAPEIAKLIDRARNPI--IMAANHYWEVPKEIRDRAELVEYKRLTQRDVINALVRILKRE 174
+ ++I++ + + + N+ ++ ++ R + L+Q ++ L +I++ E
Sbjct: 125 AQNALRRIIEKYTDNVRFCVICNYLSKIIPALQSRCTRFRFAPLSQDQMMPRLEKIIEAE 184
Query: 175 GITVPKEVLVEIAKRASGDLRAAINDLQTVV 205
+ + ++ + A GD+R +N LQ+ V
Sbjct: 185 AVQITEDGKRALLTLAKGDMRKVLNVLQSTV 215
>pir||A56284 differentiation-specific element binding protein - mouse
>gi|1022776|gb|AAA79698.1| (U36441) differentiation
specific element binding protein [Mus musculus]
Length = 1130
Score = 93.2 bits (228), Expect = 6e-18
Identities = 131/570 (22%), Positives = 238/570 (40%), Gaps = 119/570 (20%)
Query: 6 WVEKYRPRRLSEIINQE---DAISKVKAWIEAWLHGNPPKKK-----------------A 45
WV+KY+P L II Q+ +K+ W+ W +P +KK A
Sbjct: 570 WVDKYKPASLKNIIGQQGDQSCANKLLRWLRNWHKSSPEEKKHAKFGKLASKDDGSSFKA 629
Query: 46 LLLAGPPGSGKTTTVYALAREYNFEVIELNASDERTYDKIARYV-QAAYTMDILG----- 99
LL+GPPG GKTTT + +E + +ELNASD R+ + + V ++ I G
Sbjct: 630 ALLSGPPGVGKTTTASLVCQELGYSYVELNASDTRSKNSLKAVVAESLNNTSIKGFYTSG 689
Query: 100 -----KRRKIIFLDEAD----NIEPSGAPEIAKLIDRARNPIIMAANHYWEVPKEIRDRA 150
R + +DE D N + G E+ LI + PII N PK IR
Sbjct: 690 AAPSVSARHALIMDEVDGMAGNEDRGGIQELIGLIKHTKIPIICMCNDR-NHPK-IRSLV 747
Query: 151 EL---VEYKRLTQRDVINALVRILKREGITVPKEVLVEIAKRASGDLRAAINDLQTVVAG 207
+ ++R + +A++ I +EG+ +P + EI A+ D+R +++L A
Sbjct: 748 HYCFDLRFQRPRVEQIKSAMLSIAFKEGLKIPPPAMNEIILGANQDVRQVLHNLSMWCAQ 807
Query: 208 G----YEDAR--YVLAYRDVEKTVFQALGLVFASDNAKRAKLAMMNLDMSPDEFL----- 256
Y+ A+ A +D+ F VFA+ + A M+L D F
Sbjct: 808 SKALTYDQAKADSQRAKKDIRLGPFDVTRKVFAAGE----ETAHMSLMDKSDLFFHDYSI 863
Query: 257 --LWIDENIPHMYLKPEE-----------MARAYEAISKADIYLGRAQRTGNYSLWRYAI 303
L++ EN ++++KP ++RA ++I D+ + + N+SL
Sbjct: 864 APLFVQEN--YLHVKPVAAGGDMKKHLMLLSRAADSICDGDLVDNQIRSKQNWSL--LPT 919
Query: 304 DMMTAGVAVAGTKKRGFAKFYP--PNTL-KMLAESKEER--------------------- 339
+ A V + G RG+ +P P+ L K + K +R
Sbjct: 920 QAIYASV-LPGELMRGYMTQFPSFPSWLGKHSSTGKHDRIVQDLSLHMSLRTYSSKRTVN 978
Query: 340 -----STRNSIIKKIMSE-----MHMSKLEAIETMKIIKTIFEKNLDLAAHFTVFLGLSE 389
R+++++ + S+ H+ KL ++T ++K FE +++++ S+
Sbjct: 979 MDYLSHIRDALVRPLTSQGVEGAQHVIKL--MDTYYLMKEDFENIMEVSSWGGKPSAFSK 1036
Query: 390 KEVEFLA------GRENAGTIWGKALAIRRKLKKEEEKIRKERKEEEKVEVREEKPEEKV 443
+ + A +E T + + +L + +E ++ + + EK ++ V
Sbjct: 1037 LDPKVKAAFTRAYNKEAHLTPYSLQVVKTSRLSAGPALDSEYSEEFQEDDTQSEKEQDAV 1096
Query: 444 EE----KREERETKKEKEKKEEKKAEKKGK 469
E K++ R +K K ++E++ + KGK
Sbjct: 1097 ETDAMIKKKTRSSKPSKSEREKESKKGKGK 1126
>gi|6755306 replication factor C, 140 kDa [Mus musculus]
>gi|1703056|sp|P35601|AC15_MOUSE ACTIVATOR 1 140 KDA
SUBUNIT (REPLICATION FACTOR C LARGE SUBUNIT) (A1 140 KDA
SUBUNIT) (RF-C 140 KDA SUBUNIT) (ACTIVATOR 1 LARGE
SUBUNIT) (A1-P145) (DIFFERENTIATION SPECIFIC ELEMENT
BINDING PROTEIN) (ISRE-BINDING PROTEIN)
>gi|1083493|pir||A56200 replication factor C 140K chain -
mouse >gi|457742|emb|CAA51260.1| (X72711) replication
factor C [Mus musculus]
Length = 1131
Score = 92.8 bits (227), Expect = 7e-18
Identities = 131/571 (22%), Positives = 238/571 (40%), Gaps = 120/571 (21%)
Query: 6 WVEKYRPRRLSEIINQE---DAISKVKAWIEAWLHGNPPKKK------------------ 44
WV+KY+P L II Q+ +K+ W+ W +P +KK
Sbjct: 570 WVDKYKPASLKNIIGQQGDQSCANKLLRWLRNWHKSSPEEKKHAAKFGKLASKDDGSSFK 629
Query: 45 ALLLAGPPGSGKTTTVYALAREYNFEVIELNASDERTYDKIARYV-QAAYTMDILG---- 99
A LL+GPPG GKTTT + +E + +ELNASD R+ + + V ++ I G
Sbjct: 630 AALLSGPPGVGKTTTASLVCQELGYSYVELNASDTRSKNSLKAVVAESLNNTSIKGFYTS 689
Query: 100 ------KRRKIIFLDEAD----NIEPSGAPEIAKLIDRARNPIIMAANHYWEVPKEIRDR 149
R + +DE D N + G E+ LI + PII N PK IR
Sbjct: 690 GAAPSVSARHALIMDEVDGMAGNEDRGGIQELIGLIKHTKIPIICMCNDR-NHPK-IRSL 747
Query: 150 AEL---VEYKRLTQRDVINALVRILKREGITVPKEVLVEIAKRASGDLRAAINDLQTVVA 206
+ ++R + +A++ I +EG+ +P + EI A+ D+R +++L A
Sbjct: 748 VHYCFDLRFQRPRVEQIKSAMLSIAFKEGLKIPPPAMNEIILGANQDVRQVLHNLSMWCA 807
Query: 207 GG----YEDAR--YVLAYRDVEKTVFQALGLVFASDNAKRAKLAMMNLDMSPDEFL---- 256
Y+ A+ A +D+ F VFA+ + A M+L D F
Sbjct: 808 QSKALTYDQAKADSQRAKKDIRLGPFDVTRKVFAAGE----ETAHMSLMDKSDLFFHDYS 863
Query: 257 ---LWIDENIPHMYLKPEE-----------MARAYEAISKADIYLGRAQRTGNYSLWRYA 302
L++ EN ++++KP ++RA ++I D+ + + N+SL
Sbjct: 864 IAPLFVQEN--YLHVKPVAAGGDMKKHLMLLSRAADSICDGDLVDNQIRSKQNWSL--LP 919
Query: 303 IDMMTAGVAVAGTKKRGFAKFYP--PNTL-KMLAESKEER-------------------- 339
+ A V + G RG+ +P P+ L K + K +R
Sbjct: 920 TQAIYASV-LPGELMRGYMTQFPSFPSWLGKHSSTGKHDRIVQDLSLHMSLRTYSSKRTV 978
Query: 340 ------STRNSIIKKIMSE-----MHMSKLEAIETMKIIKTIFEKNLDLAAHFTVFLGLS 388
R+++++ + S+ H+ KL ++T ++K FE +++++ S
Sbjct: 979 NMDYLSHIRDALVRPLTSQGVEGAQHVIKL--MDTYYLMKEDFENIMEVSSWGGKPSAFS 1036
Query: 389 EKEVEFLA------GRENAGTIWGKALAIRRKLKKEEEKIRKERKEEEKVEVREEKPEEK 442
+ + + A +E T + + +L + +E ++ + + EK ++
Sbjct: 1037 KLDPKVKAAFTRAYNKEAHLTPYSLQVVKTSRLSTGPALDSEYSEEFQEDDTQSEKEQDA 1096
Query: 443 VEE----KREERETKKEKEKKEEKKAEKKGK 469
VE K++ R +K K ++E++ + KGK
Sbjct: 1097 VETDAMIKKKTRSSKPSKSEREKESKKGKGK 1127
>gb|AAF07781.1|AC010704_6 (AC010704) putative replication factor C; 24844-22715 [Arabidopsis
thaliana]
Length = 369
Score = 92.4 bits (226), Expect = 9e-18
Identities = 63/209 (30%), Positives = 105/209 (50%), Gaps = 16/209 (7%)
Query: 5 PWVEKYRPRRLSEIINQEDAISKVKAWIEAWLHGNPPKKKALLLAGPPGSGKTTTVYALA 64
PWVEKYRP+ L ++ D I + N K LLL GPPG+GKT+T+ A+A
Sbjct: 40 PWVEKYRPQSLDDVAAHRDIIDTIDRLT------NENKLPHLLLYGPPGTGKTSTILAVA 93
Query: 65 R-----EYNFEVIELNASDERTYDKIARYVQ--AAYTMDILGKRR-KIIFLDEADNIEPS 116
R +Y ++ELNASD+R D + + +Q A+ LGK K++ LDEAD +
Sbjct: 94 RKLYGPKYRNMILELNASDDRGIDVVRQQIQDFASTQSFSLGKSSVKLVLLDEADAMTKD 153
Query: 117 GAPEIAKLIDR--ARNPIIMAANHYWEVPKEIRDRAELVEYKRLTQRDVINALVRILKRE 174
+ ++I++ + NH ++ ++ R + L + L +++ E
Sbjct: 154 AQFALRRVIEKYTKSTRFALIGNHVNKIIPALQSRCTRFRFAPLDGVHMSQRLKHVIEAE 213
Query: 175 GITVPKEVLVEIAKRASGDLRAAINDLQT 203
+ V L + + ++GD+R A+N LQ+
Sbjct: 214 RLVVSDCGLAALVRLSNGDMRKALNILQS 242
>dbj|BAB16441.1| (AB045677) replication factor C 37kDa subunit [Oryza sativa]
Length = 339
Score = 92.4 bits (226), Expect = 9e-18
Identities = 58/215 (26%), Positives = 106/215 (48%), Gaps = 22/215 (10%)
Query: 5 PWVEKYRPRRLSEIINQEDAISKVKAWIEAWLHGNPPKKKALLLAGPPGSGKTTTVYALA 64
PWVEKYRPR++ ++ +QE+ + + ++ +L GPPG+GKTTT A+A
Sbjct: 10 PWVEKYRPRQVKDVAHQEEVVRVLTTTLQT------ADLPHMLFYGPPGTGKTTTALAIA 63
Query: 65 RE------YNFEVIELNASDERTYDKIARYVQAAYTMDILGKRR--------KIIFLDEA 110
+ Y V+ELNASD+R + + ++ + + R+ KII LDEA
Sbjct: 64 YQLYGPELYKSRVLELNASDDRGINVVRTKIKDFAAVAVGSARKGGYPCPPYKIIILDEA 123
Query: 111 DNIEPSGAPEIAKLIDRARNP--IIMAANHYWEVPKEIRDRAELVEYKRLTQRDVINALV 168
D++ + + ++ N+ + + + R +K L++ + N ++
Sbjct: 124 DSMTEDAQNALRRTMETYSKVTRFFFICNYISRIIEPLASRCAKFRFKPLSEEVMSNRIL 183
Query: 169 RILKREGITVPKEVLVEIAKRASGDLRAAINDLQT 203
I EG+++ + L ++ ++GDLR AI LQ+
Sbjct: 184 HICNEEGLSLDAQALATLSTISNGDLRRAITYLQS 218
>gb|AAC52140.1| (U07157) ISRE-binding protein [Mus musculus]
Length = 1145
Score = 92.1 bits (225), Expect = 1e-17
Identities = 132/569 (23%), Positives = 238/569 (41%), Gaps = 118/569 (20%)
Query: 6 WVEKYRPRRLSEIINQE---DAISKVKAWIEAWLHGNPPKKK-----------------A 45
WV+KY+P L II Q+ +K+ W+ W +P +KK A
Sbjct: 584 WVDKYKPASLKNIIGQQGDQSCANKLLRWLRNWHKSSPEEKKHAKFGKLASKDDGSSFKA 643
Query: 46 LLLAGPPGSGKTTTVYALAREYNFEVIELNASDERTYDKIARYV-QAAYTMDILG----- 99
LL+GPPG GKTTT + +E + +ELNASD R+ + + V ++ I G
Sbjct: 644 ALLSGPPGVGKTTTASLVCQELGYSYVELNASDTRSKNSLKAVVAESLNNTSIKGFYTSG 703
Query: 100 -----KRRKIIFLDEAD----NIEPSGAPEIAKLIDRARNPIIMAANHYWEVPKEIRDRA 150
R + +DE D N + G E+ LI + PII N PK IR
Sbjct: 704 AAPSVSARHALIMDEVDGMAGNEDRGGIQELIGLIKHTKIPIICMCNDR-NHPK-IRSLV 761
Query: 151 EL---VEYKRLTQRDVINALVRILKREGITVPKEVLVEIAKRASGDLRAAINDLQTVVAG 207
+ ++R + +A++ I +EG+ +P + EI A+ D+R +++L A
Sbjct: 762 HYCFDLRFQRPRVEQIKSAMLSIAFKEGLKIPPPAMNEIILGANQDVRQVLHNLSMWCAQ 821
Query: 208 G----YEDAR--YVLAYRDVEKTVFQALGLVFASDNAKRAKLAMMNLDMSPDEFL----- 256
Y+ A+ A +D+ F VFA+ + A M+L D F
Sbjct: 822 SKALTYDQAKADSQRAKKDIRLGPFDVTRKVFAAGE----ETAHMSLMDKSDLFFHDYSI 877
Query: 257 --LWIDENIPHMYLKPEE-----------MARAYEAISKADIYLGRAQRTGNYSLWRYAI 303
L++ EN ++++KP ++RA ++I D+ + + N+SL
Sbjct: 878 APLFVQEN--YLHVKPVAAGGDMKKHLMLLSRAADSICDGDLVDNQIRSKQNWSL--LPT 933
Query: 304 DMMTAGVAVAGTKKRGFAKFYP--PNTL-KMLAESKEER--------------------- 339
+ A V + G RG+ +P P+ L K + K +R
Sbjct: 934 QAIYASV-LPGELMRGYMTQFPSFPSWLGKHSSTGKHDRIVQDLSLHMSLRTYSSKRTVN 992
Query: 340 -----STRNSIIKKIMSE-----MHMSKLEAIETMKIIKTIFEKNLDLAAHFTVFLGLSE 389
R+++++ + S+ H+ KL ++T ++K FE +++++ S+
Sbjct: 993 MDYLSHIRDALVRPLTSQGVEGAQHVIKL--MDTYYLMKEDFENIMEVSSWGGKPSAFSK 1050
Query: 390 KEVEFLA------GRENAGTIWGKALAIRRKLKKEEEKIRKERKEEEKVEVREEKPEEKV 443
+ + A +E T + + +L + +E ++ + + EK ++ V
Sbjct: 1051 LDPKVKAAFTRAYNKEAHLTPYSLQVVKTSRLSTGPALDSEYSEEFQEDDTQSEKEQDAV 1110
Query: 444 EEKR--EERETKKEKEKKEEKKAE-KKGK 469
E ++++T+ K K E++ E KKGK
Sbjct: 1111 ETDAMIKQKKTRSSKPSKSEREKESKKGK 1139
>gb|AAD41422.1|AC007727_11 (AC007727) Similar to gb|M87339 replication factor C, 37-kDa
subunit from Homo sapiens and is a member of PF|00004
ATPases associated with various cellular activities.
[Arabidopsis thaliana]
Length = 319
Score = 91.7 bits (224), Expect = 2e-17
Identities = 60/217 (27%), Positives = 106/217 (48%), Gaps = 23/217 (10%)
Query: 5 PWVEKYRPRRLSEIINQEDAISKVKAWIEAWLHGNPPKKKALLLAGPPGSGKTTTVYALA 64
PWVEKYRP+++ ++ +QE+ + + ++ + P +L GPPG+GKTTT A+A
Sbjct: 10 PWVEKYRPKQVKDVAHQEEVVRVLTNTLQT---ADCPH---MLFYGPPGTGKTTTALAIA 63
Query: 65 RE------YNFEVIELNASDERTYDKIARYVQAAYTMDILGKRR---------KIIFLDE 109
+ Y V+ELNASD+R + + ++ + + R KII LDE
Sbjct: 64 HQLFGPELYKSRVLELNASDDRGINVVRTKIKDFAAVAVGSNHRQSGYPCPSFKIIILDE 123
Query: 110 ADNIEPSGAPEIAKLIDRARNP--IIMAANHYWEVPKEIRDRAELVEYKRLTQRDVINAL 167
AD++ + + ++ N+ + + + R +K L++ + N +
Sbjct: 124 ADSMTEDAQNALRRTMETYSKVTRFFFICNYISRIIEPLASRCAKFRFKPLSEEVMSNRI 183
Query: 168 VRILKREGITVPKEVLVEIAKRASGDLRAAINDLQTV 204
+ I EG+++ E L ++ + GDLR AI LQ V
Sbjct: 184 LHICNEEGLSLDGEALSTLSSISQGDLRRAITYLQVV 220
>gb|AAD01890.1| (AF030050) replication factor C [Rattus norvegicus]
Length = 1104
Score = 90.9 bits (222), Expect = 3e-17
Identities = 90/351 (25%), Positives = 151/351 (42%), Gaps = 62/351 (17%)
Query: 6 WVEKYRPRRLSEIINQE---DAISKVKAWIEAWLHGNPPKKK-----------------A 45
WV+KY+P L II Q+ +K+ W+ W +P +KK A
Sbjct: 570 WVDKYKPTSLKNIIGQQGDQSCANKLLRWLRNWHKSSPEEKKHAKFGKVASKDDGSSFKA 629
Query: 46 LLLAGPPGSGKTTTVYALAREYNFEVIELNASDERTYDKIARYV-QAAYTMDILG----- 99
LL+GPPG GKTTT + +E + +ELNASD R+ + + V ++ I G
Sbjct: 630 ALLSGPPGVGKTTTASLVCQELGYSYVELNASDTRSKNSLKAIVAESLNNTSIKGFYTSG 689
Query: 100 -----KRRKIIFLDEAD----NIEPSGAPEIAKLIDRARNPIIMAANHYWEVPKEIRDRA 150
R + +DE D N + G E+ LI + PII N PK IR
Sbjct: 690 ASPSVSARHALIMDEVDGMAGNEDRGGIQELIGLIKHTKIPIICMCNDR-NHPK-IRSLV 747
Query: 151 EL---VEYKRLTQRDVINALVRILKREGITVPKEVLVEIAKRASGDLRAAINDLQTVVAG 207
+ ++R + +A++ I +EG+ +P + EI A+ D+R +++L A
Sbjct: 748 HYCFDLRFQRPRVEQIKSAMLSIAFKEGLKIPPPAMNEIILGANQDVRQVLHNLSMWCAQ 807
Query: 208 G----YEDAR--YVLAYRDVEKTVFQALGLVFASDNAKRAKLAMMNLDMSPDEFL---LW 258
Y+ A+ A +D+ F VFA+ M D+ ++ L+
Sbjct: 808 SKVLTYDQAKADSQRAKKDIRLGPFDVTRKVFAAGEETPHMSLMDKSDLFFHDYSIAPLF 867
Query: 259 IDENIPHMYLKPEE-----------MARAYEAISKADIYLGRAQRTGNYSL 298
+ EN ++++KP ++RA ++I D+ + + N+SL
Sbjct: 868 VQEN--YLHVKPVAAGGDMKKHLMLLSRAADSICDGDLVANQIRSKQNWSL 916
>gb|AAG37985.1|AF069296_1 (AF069296) replication factor C3 [Plasmodium falciparum]
Length = 344
Score = 90.1 bits (220), Expect = 5e-17
Identities = 65/212 (30%), Positives = 110/212 (51%), Gaps = 18/212 (8%)
Query: 5 PWVEKYRPRRLSEIINQEDAISKVKAWIEAWLHGNPPKKKALLLAGPPGSGKTTTVYALA 64
PWVEKYRP L++II+ E IS +K +++ G P LLL GPPG+GKT+T+ A+
Sbjct: 14 PWVEKYRPNVLNDIISHEQVISTIKRFVQ---KGELPH---LLLHGPPGTGKTSTILAVC 67
Query: 65 REYNFE-----VIELNASDER----TYDKIARYVQAAYTMDILGKRR-KIIFLDEADNIE 114
+E + V+ELNASD+R D+I + ++ K K+I LDEAD++
Sbjct: 68 KELYGDKRSSFVLELNASDDRGINVIRDQIKTFAESKNHYTTCEKTTLKLIILDEADHMT 127
Query: 115 PSGAPEIAKLIDR-ARN-PIIMAANHYWEVPKEIRDRAELVEYKRLTQRDVINALVRILK 172
+ ++++ A+N + N+ ++ I+ R + L + + N + I K
Sbjct: 128 YPAQNAMRRIMENYAKNVRFCLLCNYVNKITPAIQSRCTAFRFAPLKKEYMKNKALDIAK 187
Query: 173 REGITVPKEVLVEIAKRASGDLRAAINDLQTV 204
E + + + + + + GD+R +N LQ V
Sbjct: 188 SENVNLTEGGIDSLIRVGHGDMRRILNCLQVV 219
>gb|AAC60361.1| (U60144) replication factor C large subunit [Anas platyrhynchos]
Length = 1145
Score = 89.7 bits (219), Expect = 6e-17
Identities = 108/411 (26%), Positives = 175/411 (42%), Gaps = 75/411 (18%)
Query: 6 WVEKYRPRRLSEIINQE---DAISKVKAWIEAWLHGNPPK-----------------KKA 45
WV+KY+P L II Q+ +K+ W+ W H N + KA
Sbjct: 582 WVDKYKPTSLKAIIGQQGEQSCANKLLRWLRNW-HKNTSEDGQAKASKLGGKDDGISSKA 640
Query: 46 LLLAGPPGSGKTTTVYALAREYNFEVIELNASDERTYDKIARYVQ------------AAY 93
LL+GPPG GKTTT + +E + +ELNASD R+ + + V +
Sbjct: 641 ALLSGPPGVGKTTTAALVCKELGYSYVELNASDTRSKNSLKEVVAESLNNTSIKDFCSGT 700
Query: 94 TMDILGKRRKIIFLDEAD----NIEPSGAPEIAKLIDRARNPIIMAANHYWEVPKEIRDR 149
+ + GK ++ +DE D N + G E+ LI + PII N PK IR
Sbjct: 701 SSSVSGKH--VLIMDEVDGMAGNEDRGGIQELISLIKHTKIPIICMCNDR-NHPK-IRSL 756
Query: 150 AEL---VEYKRLTQRDVINALVRILKREGITVPKEVLVEIAKRASGDLRAAINDLQTVVA 206
+ ++R + A++ I +EG+ +P + EI A+ D+R +++L A
Sbjct: 757 VHYCFDLRFQRPRLEQIKGAMMSIAFKEGLKIPPPAMHEIILAANQDIRQVLHNLNMWCA 816
Query: 207 GG----YEDAR--YVLAYRDVEKTVFQALGLVFAS-DNAKRAKLAMMNLDMSPDEFL--L 257
Y++A+ A +D++ F + VFA+ + A R L + D L L
Sbjct: 817 KDKSLTYDEAKTDASRAKKDIKLGPFDVVRKVFAAGEEASRMSLIDKSDLFFHDYSLAPL 876
Query: 258 WIDENIPHMY-------LKPEEM--ARAYEAISKADIYLGRAQRTGNYSLWRYAIDMMTA 308
++ EN H+ LK M +RA ++I D+ + + N W
Sbjct: 877 FVQENYVHVKTAAAGGDLKKHLMLLSRAADSICDGDLVDRQIRSKQN---WNLLPTQAIY 933
Query: 309 GVAVAGTKKRGFAKFYP--PNTL-KMLAESKEERSTRNSIIKKIMSEMHMS 356
+ G RG+ +P P+ L K + K ER I++++ MHMS
Sbjct: 934 SSVLPGELMRGYMSQFPVFPSWLGKFSSTGKHER-----IVQEL--AMHMS 977
>pir||D72344 DNA polymerase III, gamma and tau subunit - Thermotoga maritima
(strain MSB8) >gi|4981209|gb|AAD35768.1|AE001741_1
(AE001741) DNA polymerase III, gamma and tau subunit
[Thermotoga maritima]
Length = 478
Score = 89.7 bits (219), Expect = 6e-17
Identities = 115/483 (23%), Positives = 202/483 (41%), Gaps = 70/483 (14%)
Query: 9 KYRPRRLSEIINQEDAISKVKAWIE--AWLHGNPPKKKALLLAGPPGSGKTTTVYALARE 66
KYRP+ SE++NQ+ + I+ + HG + AGP G+GKTT LA+
Sbjct: 7 KYRPKTFSEVVNQDHVKKAIIGAIQKNSVAHG-------YIFAGPRGTGKTTLARILAKS 59
Query: 67 YNFE------------------------VIELNASDERTYDKIARYVQAAYTMDILGKRR 102
N E VIEL+A+ R D+I R A + GK
Sbjct: 60 LNCENRKGVEPCNSCRACREIDEGTFMDVIELDAASNRGIDEIRRIRDAVGYRPMEGKY- 118
Query: 103 KIIFLDEADNIEPSGAPEIAKLIDRARNPII--MAANHYWEVPKEIRDRAELVEYKRLTQ 160
K+ +DE + + K ++ + ++ +A + +VP I R ++ E++ +
Sbjct: 119 KVYIIDEVHMLTKEAFNALLKTLEEPPSHVVFVLATTNLEKVPPTIISRCQVFEFRNIPD 178
Query: 161 RDVINALVRILKREGITVPKEVLVEIAKRASGDLRAAINDLQTVVAGGYEDARYVLAYRD 220
+ L + + EGI + +E L IAKRASG LR A+ L+ V + + + L
Sbjct: 179 ELIEKRLQEVAEAEGIEIDREALSFIAKRASGGLRDALTMLEQV--WKFSEGKIDL---- 232
Query: 221 VEKTVFQALGLV-----------FASDNAKRAKLAMMNLDMSPDEFLLWIDENIPHMYLK 269
+TV +ALGL+ S + KR + ++ S ++ + I E + + ++
Sbjct: 233 --ETVHRALGLIPIQVVRDYVNAIFSGDVKRVFTVLDDVYYSGKDYEVLIQEAVEDL-VE 289
Query: 270 PEEMARAYEAISKADIYLGRAQRTGNYSLWRYAID---MMTAGVAVAGTKKRGFAKFYPP 326
E R +S DI Q ++A + + G A T +F
Sbjct: 290 DLERERGVYQVSANDIVQVSRQLLNLLREIKFAEEKRLVCKVGSAYIAT------RFSTT 343
Query: 327 NTLKM-LAESKEERSTRNSIIKKIMSEMHMSKLEAIETMKIIKTIFEKNLDLAAHFTVFL 385
N + + E + + + KK + K E E K K + E+ L ++F+
Sbjct: 344 NVQENDVREKNDNSNVQQKEEKKETVKAKEEKQEDSEFEKRFKELMEE-LKEKGDLSIFV 402
Query: 386 GLSEKEVEFLAGRENAGTIWGKAL---AIRRKLKKEEEKIRKERKEEEKVEVREEKPEEK 442
LS EV+F + KA+ +++KL + E ++ ++ +VE+R EE
Sbjct: 403 ALSLSEVQFDGEKVIISFDSSKAMHYELMKKKLPELENIFSRKLGKKVEVELRLMGKEET 462
Query: 443 VEE 445
+E+
Sbjct: 463 IEK 465
>gi|6322528 Subunit 2 of Replication Factor C; homologous to human RFC 37 kDa
subunit; Rfc2p [Saccharomyces cerevisiae]
>gi|730502|sp|P40348|RFC2_YEAST ACTIVATOR 1 41 KD
SUBUNIT (REPLICATION FACTOR C 41 KD SUBUNIT)
>gi|626873|pir||S45531 replication factor C chain RFC2 -
yeast (Saccharomyces cerevisiae)
>gi|498463|dbj|BAA05858.1| (D28499) Rfc2 protein
[Saccharomyces cerevisiae] >gi|841464|gb|AAC49061.1|
(U26028) Rfc2p [Saccharomyces cerevisiae]
>gi|1015747|emb|CAA89596.1| (Z49568) ORF YJR068w
[Saccharomyces cerevisiae] >gi|1019690|gb|AAB39294.1|
(L47993) ORF YJR068w [Saccharomyces cerevisiae]
Length = 353
Score = 88.5 bits (216), Expect = 1e-16
Identities = 72/255 (28%), Positives = 118/255 (46%), Gaps = 29/255 (11%)
Query: 1 MPEVPWVEKYRPRRLSEIINQEDAISKVKAWIEAWLHGNPPKKKALLLAGPPGSGKTTTV 60
+ + PWVEKYRP+ L E+ Q+ A++ +K +++ N P +L GPPG+GKT+T+
Sbjct: 22 LAQQPWVEKYRPKNLDEVTAQDHAVTVLKKTLKS---ANLPH---MLFYGPPGTGKTSTI 75
Query: 61 YALARE------YNFEVIELNASDERTYDKIARYVQ--AAYTMDILGKR---------RK 103
AL +E ++ELNASDER + V+ A T+ K K
Sbjct: 76 LALTKELYGPDLMKSRILELNASDERGISIVREKVKNFARLTVSKPSKHDLENYPCPPYK 135
Query: 104 IIFLDEADNIEPSGAPEIAKLID--RARNPIIMAANHYWEVPKEIRDRAELVEYKRLTQR 161
II LDEAD++ + + ++ + N+ + + R +K L
Sbjct: 136 IIILDEADSMTADAQSALRRTMETYSGVTRFCLICNYVTRIIDPLASRCSKFRFKALDAS 195
Query: 162 DVINALVRILKREGITVPKEVLVEIAKRASGDLRAAINDLQTVVAGGYEDARYVLAYRDV 221
+ I+ L I ++E + VL I ++GDLR I LQ+ G A+Y+ +++
Sbjct: 196 NAIDRLRFISEQENVKCDDGVLERILDISAGDLRRGITLLQSASKG----AQYLGDGKNI 251
Query: 222 EKTVFQALGLVFASD 236
T + L V D
Sbjct: 252 TSTQVEELAGVVPHD 266
>gb|AAF69583.1|AC019154_2 (AC019154) Replication Factor C [Leishmania major]
Length = 364
Score = 87.0 bits (212), Expect = 4e-16
Identities = 74/308 (24%), Positives = 138/308 (44%), Gaps = 49/308 (15%)
Query: 4 VPWVEKYRPRRLSEIINQEDAISKVKAWIEAWLHGNPPKKKALLLAGPPGSGKTTTVYAL 63
+PWVEKYRP L ++ ED +S ++ +++ GN P LLL GPPG+GKTTT+ A
Sbjct: 17 LPWVEKYRPSTLESVVAHEDILSTLRHLMDS---GNMPH---LLLYGPPGTGKTTTIKAC 70
Query: 64 A------REYNFEVIELNASDERTYDKIAR----YVQAAYTMDILG-------------K 100
A V+E+NASD+R D + + + + ++G
Sbjct: 71 AYYLYGKARVRANVLEMNASDDRGIDVVRQQTREFASTSSIFSMMGTGSSTGGGSGGPAA 130
Query: 101 RRKIIFLDEADNIEPSGAPEIAKLIDR-ARN-PIIMAANHYWEVPKEIRDRAELVEYKRL 158
+ K++ LDEAD + + ++I++ RN + NH ++ ++ R + +
Sbjct: 131 KFKLVILDEADQMSHDAQAALRRVIEKYTRNVRFCILCNHINKIIPALQSRCTRFRFAPV 190
Query: 159 TQRDVINALVRILKREGITVPKEVLVEIAKRASGDLRAAINDLQTVVAGGYEDARYVLAY 218
+ ++ L + ++EG+ + L + + GDLR +N +Q A + A
Sbjct: 191 KKSSMMPRLRYVAEQEGVKYTTDGLAAAFRLSHGDLRRCLNTMQ---------ASALSAN 241
Query: 219 RDVEKTVFQALGLVFASDNAKRAKLAMMNLDMSPDEFLL-WI--DENIPHMYLKPEEMAR 275
E++V++ G N A + + DM +F W+ +E++ + ++ R
Sbjct: 242 EITEESVYRVTG------NPTPADVTAIVSDMLSSDFATSWVKAEESVVQKGISMADLTR 295
Query: 276 AYEAISKA 283
+ A
Sbjct: 296 EIHPVMMA 303
>gi|4506485 replication factor C (activator 1) 1 (145kD) [Homo sapiens]
>gi|2136100|pir||A49651 replication factor C large
subunit - human >gi|410218|gb|AAA16121.1| (L23320)
replication factor C large subunit [Homo sapiens]
Length = 1148
Score = 84.7 bits (206), Expect = 2e-15
Identities = 135/568 (23%), Positives = 230/568 (39%), Gaps = 115/568 (20%)
Query: 6 WVEKYRPRRLSEIINQE---DAISKVKAWIEAWLHGNPPKKK------------------ 44
WV+KY+P L II Q+ +K+ W+ W + KK
Sbjct: 586 WVDKYKPTSLKTIIGQQGDQSCANKLLRWLRNWQKSSSEDKKHAAKFGKFSGKDDGSSFK 645
Query: 45 ALLLAGPPGSGKTTTVYALAREYNFEVIELNASDERTYDKIARYV-QAAYTMDILG---- 99
A LL+GPPG GKTTT + +E + +ELNASD R+ + V ++ I G
Sbjct: 646 AALLSGPPGVGKTTTASLVCQELGYSYVELNASDTRSKSSLKAIVAESLNNTSIKGFYSN 705
Query: 100 ------KRRKIIFLDEAD----NIEPSGAPEIAKLIDRARNPIIMAANHYWEVPKEIRDR 149
+ + +DE D N + G E+ LI + PII N PK IR
Sbjct: 706 GAASSVSTKHALIMDEVDGMAGNEDRGGIQELIGLIKHTKIPIICMCNDR-NHPK-IRSL 763
Query: 150 AEL---VEYKRLTQRDVINALVRILKREGITVPKEVLVEIAKRASGDLRAAINDLQTVVA 206
+ ++R + A++ I +EG+ +P + EI A+ D+R +++L A
Sbjct: 764 VHYCFDLRFQRPRVEQIKGAMMSIAFKEGLKIPPPAMNEIILGANQDIRQVLHNLSMWCA 823
Query: 207 GG----YEDAR--YVLAYRDVEKTVFQALGLVFASDNAKRAKLAMMNLDMSPDEFL---- 256
Y+ A+ A +D++ F VFA+ + A M+L D F
Sbjct: 824 RSKALTYDQAKADSHRAKKDIKMGPFDVARKVFAAGE----ETAHMSLVDKSDLFFHDYS 879
Query: 257 ---LWIDENIPHMYLKPEE-----------MARAYEAISKADIYLGRAQRTGNYSLWRYA 302
L++ EN ++++KP ++RA ++I D+ + + N+SL
Sbjct: 880 IAPLFVQEN--YIHVKPVAAGGDMKKHLMLLSRAADSICDGDLVDSQIRSKQNWSL--LP 935
Query: 303 IDMMTAGVAVAGTKKRGFAKFYP--PNTL-KMLAESKEER---------STRNSIIKKIM 350
+ A V + G RG+ +P P+ L K + K +R S R K+ +
Sbjct: 936 AQAIYASV-LPGELMRGYMTQFPTFPSWLGKHSSTGKHDRIVQDLALHMSLRTYSSKRTV 994
Query: 351 SEMHMSKLE--------------------AIETMKIIKTIFEKNLDLAA---HFTVFLGL 387
+ ++S L ++T ++K FE +++++ + F L
Sbjct: 995 NMDYLSLLRDALVQPLTSQGVDGVQDVVALMDTYYLMKEDFENIMEISSWGGKPSPFSKL 1054
Query: 388 SEK-EVEFLAGRENAGTIWGKAL-AIRRKLKKEEEKIRKERKEE--EKVEVREEKPEEKV 443
K + F + +L AI+ + E EE E +EK ++ +
Sbjct: 1055 DPKVKAAFTRAYNKEAHLTPYSLQAIKASRHSTSPSLDSEYNEELNEDDSQSDEKDQDAI 1114
Query: 444 E-EKREERETKKEKEKKEEK-KAEKKGK 469
E + +++TK K K EK K +KGK
Sbjct: 1115 ETDAMIKKKTKSSKPSKPEKDKEPRKGK 1142
>gi|11435908 replication factor C (activator 1) 1 (145kD) [Homo sapiens]
Length = 1032
Score = 84.7 bits (206), Expect = 2e-15
Identities = 135/568 (23%), Positives = 230/568 (39%), Gaps = 115/568 (20%)
Query: 6 WVEKYRPRRLSEIINQE---DAISKVKAWIEAWLHGNPPKKK------------------ 44
WV+KY+P L II Q+ +K+ W+ W + KK
Sbjct: 470 WVDKYKPTSLKTIIGQQGDQSCANKLLRWLRNWQKSSSEDKKHAAKFGKFSGKDDGSSFK 529
Query: 45 ALLLAGPPGSGKTTTVYALAREYNFEVIELNASDERTYDKIARYV-QAAYTMDILG---- 99
A LL+GPPG GKTTT + +E + +ELNASD R+ + V ++ I G
Sbjct: 530 AALLSGPPGVGKTTTASLVCQELGYSYVELNASDTRSKSSLKAIVAESLNNTSIKGFYSN 589
Query: 100 ------KRRKIIFLDEAD----NIEPSGAPEIAKLIDRARNPIIMAANHYWEVPKEIRDR 149
+ + +DE D N + G E+ LI + PII N PK IR
Sbjct: 590 GAASSVSTKHALIMDEVDGMAGNEDRGGIQELIGLIKHTKIPIICMCNDR-NHPK-IRSL 647
Query: 150 AEL---VEYKRLTQRDVINALVRILKREGITVPKEVLVEIAKRASGDLRAAINDLQTVVA 206
+ ++R + A++ I +EG+ +P + EI A+ D+R +++L A
Sbjct: 648 VHYCFDLRFQRPRVEQIKGAMMSIAFKEGLKIPPPAMNEIILGANQDIRQVLHNLSMWCA 707
Query: 207 GG----YEDAR--YVLAYRDVEKTVFQALGLVFASDNAKRAKLAMMNLDMSPDEFL---- 256
Y+ A+ A +D++ F VFA+ + A M+L D F
Sbjct: 708 RSKALTYDQAKADSHRAKKDIKMGPFDVARKVFAAGE----ETAHMSLVDKSDLFFHDYS 763
Query: 257 ---LWIDENIPHMYLKPEE-----------MARAYEAISKADIYLGRAQRTGNYSLWRYA 302
L++ EN ++++KP ++RA ++I D+ + + N+SL
Sbjct: 764 IAPLFVQEN--YIHVKPVAAGGDMKKHLMLLSRAADSICDGDLVDSQIRSKQNWSL--LP 819
Query: 303 IDMMTAGVAVAGTKKRGFAKFYP--PNTL-KMLAESKEER---------STRNSIIKKIM 350
+ A V + G RG+ +P P+ L K + K +R S R K+ +
Sbjct: 820 AQAIYASV-LPGELMRGYMTQFPTFPSWLGKHSSTGKHDRIVQDLALHMSLRTYSSKRTV 878
Query: 351 SEMHMSKLE--------------------AIETMKIIKTIFEKNLDLAA---HFTVFLGL 387
+ ++S L ++T ++K FE +++++ + F L
Sbjct: 879 NMDYLSLLRDALVQPLTSQGVDGVQDVVALMDTYYLMKEDFENIMEISSWGGKPSPFSKL 938
Query: 388 SEK-EVEFLAGRENAGTIWGKAL-AIRRKLKKEEEKIRKERKEE--EKVEVREEKPEEKV 443
K + F + +L AI+ + E EE E +EK ++ +
Sbjct: 939 DPKVKAAFTRAYNKEAHLTPYSLQAIKASRHSTSPSLDSEYNEELNEDDSQSDEKDQDAI 998
Query: 444 E-EKREERETKKEKEKKEEK-KAEKKGK 469
E + +++TK K K EK K +KGK
Sbjct: 999 ETDAMIKKKTKSSKPSKPEKDKEPRKGK 1026
>sp|P35251|AC15_HUMAN ACTIVATOR 1 140 KDA SUBUNIT (REPLICATION FACTOR C LARGE SUBUNIT) (A1
140 KDA SUBUNIT) (RF-C 140 KDA SUBUNIT) (ACTIVATOR 1
LARGE SUBUNIT) (DNA-BINDING PROTEIN PO-GA)
>gi|422807|pir||JN0599 DNA-binding protein PO-GA - human
>gi|296908|emb|CAA80355.1| (Z22642) PO-GA [Homo sapiens]
>gi|307338|gb|AAA86853.1| (L14922) DNA-binding protein
[Homo sapiens] >gi|2827257|gb|AAB99788.1| (AF040250) DNA
binding protein [Homo sapiens]
Length = 1147
Score = 84.3 bits (205), Expect = 3e-15
Identities = 135/567 (23%), Positives = 229/567 (39%), Gaps = 114/567 (20%)
Query: 6 WVEKYRPRRLSEIINQE---DAISKVKAWIEAWLHGNPPKKK-----------------A 45
WV+KY+P L II Q+ +K+ W+ W + KK A
Sbjct: 586 WVDKYKPTSLKTIIGQQGDQSCANKLLLWLRNWQKSSSEDKKHSKFGKFSGKDDNSSFKA 645
Query: 46 LLLAGPPGSGKTTTVYALAREYNFEVIELNASDERTYDKIARYV-QAAYTMDILG----- 99
LL+GPPG GKTTT + +E + +ELN SD R+ + V ++ I G
Sbjct: 646 ALLSGPPGVGKTTTASLVCQELGYSYVELNRSDTRSKSSLKAIVAESLNNTSIKGFYSNG 705
Query: 100 -----KRRKIIFLDEAD----NIEPSGAPEIAKLIDRARNPIIMAANHYWEVPKEIRDRA 150
+ + +DE D N + G E+ LI + PII N PK IR
Sbjct: 706 AASSVSTKHALIMDEVDGMAGNEDRGGIQELIGLIKHTKIPIICMCNDR-NHPK-IRSLV 763
Query: 151 EL---VEYKRLTQRDVINALVRILKREGITVPKEVLVEIAKRASGDLRAAINDLQTVVAG 207
+ ++R + A++ I +EG+ +P + EI A+ D+R +++L A
Sbjct: 764 HYCFDLRFQRPRVEQIKGAMMSIAFKEGLKIPPPAMNEIILGANQDIRQVLHNLSMWCAR 823
Query: 208 G----YEDAR--YVLAYRDVEKTVFQALGLVFASDNAKRAKLAMMNLDMSPDEFL----- 256
Y+ A+ A +D++ F VFA+ + A M+L D F
Sbjct: 824 SKALTYDQAKADSHRAKKDIKMGPFDVARKVFAAGE----ETAHMSLVDKSDLFFHDYSI 879
Query: 257 --LWIDENIPHMYLKPEE-----------MARAYEAISKADIYLGRAQRTGNYSLWRYAI 303
L++ EN ++++KP ++RA ++I D+ + + N+SL
Sbjct: 880 APLFVQEN--YIHVKPVAAGGDMKKHLMLLSRAADSICDGDLVDSQIRSKQNWSL--LPA 935
Query: 304 DMMTAGVAVAGTKKRGFAKFYP--PNTL-KMLAESKEER---------STRNSIIKKIMS 351
+ A V + G RG+ +P P+ L K + K +R S R K+ ++
Sbjct: 936 QAIYASV-LPGELMRGYMTQFPTFPSWLGKHSSTGKHDRIVQDLALHMSLRTYSSKRTVN 994
Query: 352 EMHMSKLE--------------------AIETMKIIKTIFEKNLDLAA---HFTVFLGLS 388
++S L ++T ++K FE +++++ + F L
Sbjct: 995 MDYLSLLRDALVQPLTSQGVDGVQDVVALMDTYYLMKEDFENIMEISSWGGKPSPFSKLD 1054
Query: 389 EK-EVEFLAGRENAGTIWGKAL-AIRRKLKKEEEKIRKERKEE--EKVEVREEKPEEKVE 444
K + F + AL AI+ + E EE E +EK ++ +E
Sbjct: 1055 PKVKAAFTRAYNKEAHLTPYALQAIKASRHSTSPSLDSEYNEELNEDDSQSDEKDQDAIE 1114
Query: 445 -EKREERETKKEKEKKEEK-KAEKKGK 469
+ +++TK K K EK K +KGK
Sbjct: 1115 TDAMIKKKTKSSKPSKPEKDKEPRKGK 1141
>sp|Q09843|RFC2_SCHPO PROBABLE ACTIVATOR 1 41 KD SUBUNIT (REPLICATION FACTOR C 41 KD
SUBUNIT) >gi|2130334|pir||S62493 replication factor C
activator 1 41 kd subunit - fission yeast
(Schizosaccharomyces pombe) >gi|1039340|emb|CAA91237.1|
(Z64354) replication factor C activator 1 41 kd subunit
[Schizosaccharomyces pombe]
Length = 340
Score = 84.3 bits (205), Expect = 3e-15
Identities = 62/215 (28%), Positives = 105/215 (48%), Gaps = 21/215 (9%)
Query: 4 VPWVEKYRPRRLSEIINQEDAISKVKAWIEAWLHGNPPKKKALLLAGPPGSGKTTTVYAL 63
+PWVE YRP+ L ++ +QE + +K + L N P +L G PG+GKT+T+ AL
Sbjct: 19 IPWVELYRPKTLDQVSSQESTVQVLK---KTLLSNNLPH---MLFYGSPGTGKTSTILAL 72
Query: 64 ARE------YNFEVIELNASDER----TYDKIARYVQAAYTMDILG---KRRKIIFLDEA 110
+RE V+ELNASDER +K+ + + T + G KII LDEA
Sbjct: 73 SRELFGPQLMKSRVLELNASDERGISIIREKVKSFAKTTVTNKVDGYPCPPFKIIILDEA 132
Query: 111 DNIEPSGAPEIAKLIDR-AR-NPIIMAANHYWEVPKEIRDRAELVEYKRLTQRDVINALV 168
D++ + + ++ AR + N+ + + R +K L +++ L
Sbjct: 133 DSMTQDAQAALRRTMESYARITRFCLICNYMTRIIDPLSSRCSKYRFKPLDNENMVKRLE 192
Query: 169 RILKREGITVPKEVLVEIAKRASGDLRAAINDLQT 203
I + +++ V+ + + + GD+R AI LQ+
Sbjct: 193 FIAADQAVSMEPGVVNALVECSGGDMRKAITFLQS 227
>pir||T39941 hypothetical protein SPBC23E6.07c - fission yeast
(Schizosaccharomyces pombe) >gi|3116125|emb|CAA18875.1|
(AL023287) putative activator 1 subunit (replication
factor) [Schizosaccharomyces pombe]
Length = 934
Score = 82.3 bits (200), Expect = 1e-14
Identities = 58/231 (25%), Positives = 102/231 (44%), Gaps = 30/231 (12%)
Query: 2 PEVPWVEKYRPRRLSEIINQEDAISKVKAWIEAWLHGNPPKK------------KALLLA 49
P W KY P L +I + + K++ W++ + H N KA+LL+
Sbjct: 357 PSQIWTSKYAPTSLKDICGNKGVVQKLQKWLQDY-HKNRKSNFNKPGPDGLGLYKAVLLS 415
Query: 50 GPPGSGKTTTVYALAREYNFEVIELNASDERT-------------YDKIARYVQAAYTMD 96
GPPG GKTT + +A+ ++V+ELNASD R+ +A Y
Sbjct: 416 GPPGIGKTTAAHLVAKLEGYDVLELNASDTRSKRLLDEQLFGVTDSQSLAGYFGTKANPV 475
Query: 97 ILGKRRKIIFLDEADNI---EPSGAPEIAKLIDRARNPIIMAANHYWEVPKEIRDRAEL- 152
+ K R ++ +DE D + + G ++ +I ++ PII N DR
Sbjct: 476 DMAKSRLVLIMDEIDGMSSGDRGGVGQLNMIIKKSMIPIICICNDRAHPKLRPLDRTTFD 535
Query: 153 VEYKRLTQRDVINALVRILKREGITVPKEVLVEIAKRASGDLRAAINDLQT 203
+ ++R + + ++ I REG+ + + + ++ + D+R IN L T
Sbjct: 536 LRFRRPDANSMRSRIMSIAYREGLKLSPQAVDQLVQGTQSDMRQIINLLST 586
>gi|6324791 Subunit 1 of Replication Factor C; homologous to human RFC 140 kDa
subunit; Rfc1p [Saccharomyces cerevisiae]
>gi|584899|sp|P38630|RFC1_YEAST ACTIVATOR 1 95 KDA
SUBUNIT (REPLICATION FACTOR C 95 KDA SUBUNIT) (CELL
DIVISION CONTROL PROTEIN 44) >gi|626116|pir||S44763
replication factor C chain RFC1 - yeast (Saccharomyces
cerevisiae) >gi|437274|gb|AAC48916.1| (U03102) Cdc44p
[Saccharomyces cerevisiae] >gi|841462|gb|AAC49060.1|
(U26027) Rfc1p [Saccharomyces cerevisiae]
>gi|1050769|emb|CAA63180.1| (X92441) YOR50-7
[Saccharomyces cerevisiae] >gi|1420505|emb|CAA99434.1|
(Z75125) ORF YOR217w [Saccharomyces cerevisiae]
Length = 861
Score = 81.9 bits (199), Expect = 1e-14
Identities = 57/227 (25%), Positives = 102/227 (44%), Gaps = 28/227 (12%)
Query: 6 WVEKYRPRRLSEIINQEDAISKVKAWIEAWLHGNPPKKK-----------ALLLAGPPGS 54
W KY P L ++ + ++ K+K W+ W + K A +L GPPG
Sbjct: 298 WTVKYAPTNLQQVCGNKGSVMKLKNWLANWENSKKNSFKHAGKDGSGVFRAAMLYGPPGI 357
Query: 55 GKTTTVYALAREYNFEVIELNASDERTYDKIARYVQAAY-TMDILG------------KR 101
GKTT + +A+E ++++E NASD R+ + V+ A M ++G +
Sbjct: 358 GKTTAAHLVAQELGYDILEQNASDVRSKTLLNAGVKNALDNMSVVGYFKHNEEAQNLNGK 417
Query: 102 RKIIFLDEADNI---EPSGAPEIAKLIDRARNPIIMAANHYWEVPKEIRDRAEL-VEYKR 157
+I +DE D + + G ++A+ + P+I+ N DR L ++++R
Sbjct: 418 HFVIIMDEVDGMSGGDRGGVGQLAQFCRKTSTPLILICNERNLPKMRPFDRVCLDIQFRR 477
Query: 158 LTQRDVINALVRILKREGITVPKEVLVEIAKRASGDLRAAINDLQTV 204
+ + L+ I RE + V+ + + GD+R IN L T+
Sbjct: 478 PDANSIKSRLMTIAIREKFKLDPNVIDRLIQTTRGDIRQVINLLSTI 524
>sp|P35600|GNF1_DROME GERMLINE TRANSCRIPTION FACTOR 1 >gi|304728|gb|AAA28573.1| (L17340)
transcription factor [Drosophila melanogaster]
Length = 986
Score = 81.1 bits (197), Expect = 2e-14
Identities = 69/278 (24%), Positives = 119/278 (41%), Gaps = 41/278 (14%)
Query: 6 WVEKYRPRRLSEIINQEDA---ISKVKAWIEAWLHGNPPKKK-----------------A 45
WV+K++P + EI+ Q A ++K+ W+ W + KK A
Sbjct: 423 WVDKHKPTSIKEIVGQAGAASNVTKLMNWLSKWYVNHDGNKKPQRPNPWAKNDDGSFYKA 482
Query: 46 LLLAGPPGSGKTTTVYALAREYNFEVIELNASDERTYDKIARYVQAAYTMDILG------ 99
LL+GPPG GKTTT + +E F+ +E NASD R+ + V + L
Sbjct: 483 ALLSGPPGIGKTTTATLVVKELGFDAVEFNASDTRSKRLLKDEVSTLLSNKSLSGYFTGQ 542
Query: 100 ----KRRKIIFLDEAD----NIEPSGAPEIAKLIDRARNPIIMAANHYWEVPKEIRDRAE 151
R+ ++ +DE D N + G E+ LI + PII N PK IR
Sbjct: 543 GQAVSRKHVLIMDEVDAMAGNEDRGGMQELIALIKDSSIPIICMCNDR-NHPK-IRSLVN 600
Query: 152 L---VEYKRLTQRDVINALVRILKREGITVPKEVLVEIAKRASGDLRAAINDLQTVVA-- 206
+ ++R + ++ I +E + + + EI + D+R +IN + + A
Sbjct: 601 YCYDLRFQRPRLEQIKGKIMSICFKEKVKISPAKVEEIIAATNNDIRQSINHIALLSAKE 660
Query: 207 GGYEDARYVLAYRDVEKTVFQALGLVFASDNAKRAKLA 244
+ + +A +D++ ++ + VF +D K A
Sbjct: 661 DASQKSGQQVATKDLKLGPWEVVRKVFTADEHKHMSFA 698
>gb|AAB58311.1| (U97685) replication factor C large subunit [Drosophila
melanogaster] >gi|7296805|gb|AAF52082.1| (AE003604) Gnf1
gene product [Drosophila melanogaster]
Length = 986
Score = 81.1 bits (197), Expect = 2e-14
Identities = 69/278 (24%), Positives = 119/278 (41%), Gaps = 41/278 (14%)
Query: 6 WVEKYRPRRLSEIINQEDA---ISKVKAWIEAWLHGNPPKKK-----------------A 45
WV+K++P + EI+ Q A ++K+ W+ W + KK A
Sbjct: 423 WVDKHKPTSIKEIVGQAGAASNVTKLMNWLSKWYVNHDGNKKPQRPNPWAKNDDGSFYKA 482
Query: 46 LLLAGPPGSGKTTTVYALAREYNFEVIELNASDERTYDKIARYVQAAYTMDILG------ 99
LL+GPPG GKTTT + +E F+ +E NASD R+ + V + L
Sbjct: 483 ALLSGPPGIGKTTTATLVVKELGFDAVEFNASDTRSKRLLKDEVSTLLSNKSLSGYFTGQ 542
Query: 100 ----KRRKIIFLDEAD----NIEPSGAPEIAKLIDRARNPIIMAANHYWEVPKEIRDRAE 151
R+ ++ +DE D N + G E+ LI + PII N PK IR
Sbjct: 543 GQAVSRKHVLIMDEVDGMAGNEDRGGMQELIALIKDSSIPIICMCNDR-NHPK-IRSLVN 600
Query: 152 L---VEYKRLTQRDVINALVRILKREGITVPKEVLVEIAKRASGDLRAAINDLQTVVA-- 206
+ ++R + ++ I +E + + + EI + D+R +IN + + A
Sbjct: 601 YCYDLRFQRPRLEQIKGKIMSICFKEKVKISPAKVEEIIAATNNDIRQSINHIALLSAKE 660
Query: 207 GGYEDARYVLAYRDVEKTVFQALGLVFASDNAKRAKLA 244
+ + +A +D++ ++ + VF +D K A
Sbjct: 661 DASQKSGQQVATKDLKLGPWEVVRKVFTADEHKHMSFA 698
>pir||T18305 replication factor C like protein - Emericella nidulans
>gi|1840142|gb|AAB63523.1| (U86619) replication factor C
like protein [Aspergillus nidulans]
Length = 1092
Score = 80.8 bits (196), Expect = 3e-14
Identities = 57/227 (25%), Positives = 100/227 (43%), Gaps = 28/227 (12%)
Query: 6 WVEKYRPRRLSEIINQEDAISKVKAWIEAWLHG------NPPKK-----KALLLAGPPGS 54
W KY P L+ I + A+ K++AW+ W P K +++++ GPPG
Sbjct: 471 WTSKYAPTSLNMICGNKGAVEKLQAWLRNWRKSAKANFTKPGKDGSGLYRSVMIHGPPGI 530
Query: 55 GKTTTVYALAREYNFEVIELNASDERT-------------YDKIARYVQAAYTMDILGKR 101
GKTT + +A+ ++V+E NASD R+ + Y + GK+
Sbjct: 531 GKTTAAHLVAKLEGYDVVESNASDTRSKKLVESGLLGVLDTTSLQGYFSTSNKKVESGKK 590
Query: 102 RKIIFLDEADNI---EPSGAPEIAKLIDRARNPIIMAANHYWEVPKEIRDRAEL-VEYKR 157
++ +DE D + + G +A + + + P+I+ N + D + ++R
Sbjct: 591 NLVLIMDEVDGMSAGDRGGVGAMAAIAKKTQIPLILICNERRLPKMKPFDHVTFEIPFRR 650
Query: 158 LTQRDVINALVRILKREGITVPKEVLVEIAKRASGDLRAAINDLQTV 204
T V L+ I RE + +P +VL + + D+R IN L V
Sbjct: 651 PTVEQVRARLLTICFREKMKIPPQVLDSLIEGTHADIRQVINMLSAV 697
>pir||T18306 replication factor C protein - Emericella nidulans
>gi|2258283|gb|AAB63574.1| (U86620) replication factor C
like protein [Aspergillus nidulans]
Length = 1092
Score = 80.8 bits (196), Expect = 3e-14
Identities = 57/227 (25%), Positives = 100/227 (43%), Gaps = 28/227 (12%)
Query: 6 WVEKYRPRRLSEIINQEDAISKVKAWIEAWLHG------NPPKK-----KALLLAGPPGS 54
W KY P L+ I + A+ K++AW+ W P K +++++ GPPG
Sbjct: 471 WTSKYAPTSLNMICGNKGAVEKLQAWLRNWRKSAKANFTKPGKDGSGLYRSVMIHGPPGI 530
Query: 55 GKTTTVYALAREYNFEVIELNASDERT-------------YDKIARYVQAAYTMDILGKR 101
GKTT + +A+ ++V+E NASD R+ + Y + GK+
Sbjct: 531 GKTTAAHLVAKLEGYDVVESNASDTRSKKLVESGLLGVLDTTSLQGYFSTSNKKVESGKK 590
Query: 102 RKIIFLDEADNI---EPSGAPEIAKLIDRARNPIIMAANHYWEVPKEIRDRAEL-VEYKR 157
++ +DE D + + G +A + + + P+I+ N + D + ++R
Sbjct: 591 NLVLIMDEVDGMSAGDRGGVGAMAAIAKKTQIPLILICNERRLPKMKPFDHVTFEIPFRR 650
Query: 158 LTQRDVINALVRILKREGITVPKEVLVEIAKRASGDLRAAINDLQTV 204
T V L+ I RE + +P +VL + + D+R IN L V
Sbjct: 651 PTVEQVRARLLTICFREKMKIPPQVLDSLIEGTHADIRQVINMLSAV 697
>pir||T20230 hypothetical protein C54G10.2 - Caenorhabditis elegans
>gi|3875243|emb|CAA99812.1| (Z75532) predicted using
Genefinder~Similarity to Human Replication factor C
activator 1 140 KD subunit (SW:AC15_HUMAN), contains
similarity to Pfam domain: PF00004 (ATPases associated
with various cellular activities (AAA)), Score=-10.6,
E-value=5.7e->
Length = 839
Score = 80.8 bits (196), Expect = 3e-14
Identities = 67/245 (27%), Positives = 113/245 (45%), Gaps = 46/245 (18%)
Query: 2 PEVPWVEKYRPRRLSEIINQ---EDAISKVKAWIEAWLHGN--------PPKK------- 43
P + WV+KY+P+R+ E++ Q + I+K+ WI+ W N PK
Sbjct: 276 PALSWVDKYKPKRMGELVGQNGDKSPINKLLEWIKDWAKHNLGEGAKIKKPKPAPWMSSQ 335
Query: 44 -----KALLLAGPPGSGKTTTVYALAREYNFEVIELNASDERTYD----KIARYVQAAYT 94
KA LL+G PG GKTT Y ++ +++E+NASD R+ KI +
Sbjct: 336 DGTSFKAALLSGSPGVGKTTCAYMACQQLGLQLVEMNASDVRSKKHLEAKIGELSGSHQI 395
Query: 95 MDILGKRR----------KIIFLDEAD----NIEPSGAPEIAKLIDRARNPIIMAANHYW 140
G ++ I+ +DE D N + +G E+ ++I ++ PII N
Sbjct: 396 EQFFGAKKCAPQDNQKVHHILIMDEVDGMSGNEDRAGISELIQIIKESKIPIICICNDR- 454
Query: 141 EVPKEIRDRAEL---VEYKRLTQRDVINALVRILKREGITVPKEVLVEIAKRASGDLRAA 197
+ PK IR A + + + + + ++ I +E + + KE L EI + + D+R
Sbjct: 455 QHPK-IRTLANYCYDLRFPKPRVETIRSRMMTICSQEKMKIGKEELDEIIELSGHDVRQT 513
Query: 198 INDLQ 202
I +LQ
Sbjct: 514 IYNLQ 518
>sp|P53016|AC12_CAEEL PUTATIVE ACTIVATOR 1 37 KD SUBUNIT (REPLICATION FACTOR C 37 KD
SUBUNIT) (A1 37 KD SUBUNIT) (RF-C 37 KD SUBUNIT) (RFC37)
>gi|7444554|pir||T16219 hypothetical protein F31E3.3 -
Caenorhabditis elegans >gi|1072162|gb|AAA81689.1|
(U40935) similar to replication factor C 37 kda subunit
(human) and F44B9.8 [Caenorhabditis elegans]
Length = 334
Score = 80.0 bits (194), Expect = 5e-14
Identities = 60/227 (26%), Positives = 107/227 (46%), Gaps = 27/227 (11%)
Query: 6 WVEKYRPRRLSEIINQEDAISKVKAWIEAWLHGNPPKKKALLLAGPPGSGKTTTVYALAR 65
W EKYRP+ L +I Q++ ++ +K ++ LL GPPG+GKT+ A R
Sbjct: 17 WTEKYRPKTLDDIAYQDEVVTMLKGALQG------RDLPHLLFYGPPGTGKTSAALAFCR 70
Query: 66 E------YNFEVIELNASDERTYDKIARYVQA--------AYTMDILGKRRKIIFLDEAD 111
+ ++ V++LNASDER + + +Q+ ++ D+L + KII LDE D
Sbjct: 71 QLFPKNIFHDRVLDLNASDERGIAVVRQKIQSFSKSSLGHSHREDVL--KLKIIILDEVD 128
Query: 112 NIEPSGAPEIAKLID--RARNPIIMAANHYWEVPKEIRDRAELVEYKRLTQRDVINALVR 169
+ + ++I+ I+ N+ + + R +K L + L
Sbjct: 129 AMTREAQAAMRRVIEDFSKTTRFILICNYVSRLIPPVVSRCAKFRFKSLPAEIQVQRLRT 188
Query: 170 ILKREGITVPKEVLVEIAKRASGDLRAAINDLQT---VVAGGYEDAR 213
I EG + + L ++ + + GDLR A+ LQ+ ++ G ++AR
Sbjct: 189 ICDAEGTPMSDDELKQVMEYSEGDLRRAVCTLQSLAPILKSGDDNAR 235
>sp|P34429|AC11_CAEEL PUTATIVE ACTIVATOR 1 36 KD SUBUNIT (REPLICATION FACTOR C 36 KD
SUBUNIT) (A1 36 KD SUBUNIT) (RF-C 36 KD SUBUNIT) (RFC36)
>gi|630627|pir||S44809 F44B9.8 protein - Caenorhabditis
elegans >gi|388588|gb|AAA28028.1| (L23648) homology with
A1 replicative polymerase accessory protein; putative
[Caenorhabditis elegans]
Length = 447
Score = 80.0 bits (194), Expect = 5e-14
Identities = 80/269 (29%), Positives = 120/269 (43%), Gaps = 58/269 (21%)
Query: 4 VPWVEKYRPRRLSEIINQEDAISKVKAWIEAWLHGNPPKKKALLLAGPPGSGKTTTVYAL 63
+PWVEKYRP +L E++ E VK +I LL GPPG+GKTTTV A
Sbjct: 29 LPWVEKYRPSKLDELVAHEQI---VKTYILVTKFIENRTLPHLLFYGPPGTGKTTTVLAA 85
Query: 64 AREYNFE------VIELNASDERTYDKI---------ARYVQAAYTMDILGK-RRKIIFL 107
AR+ V+ELNASDER D + + +QA T G K++ L
Sbjct: 86 ARQMYSPTKMASMVLELNASDERGIDVVRNTIVNFAQTKGLQAFSTSSNTGTVPFKLVIL 145
Query: 108 DEADNIEPSGAPEIAKL--IDRARNPIIMAANHYWEVPKE-------------------- 145
DEAD + + +L D +N II N Y+ V ++
Sbjct: 146 DEADAMTKDAQNALRRLDKTDYEQNIIIHNVNIYFRVIEKYTDNVRFCIICNYLASIVPA 205
Query: 146 IRDRAELVEYKRLTQRDVINALVRILKREGITVP---KEVLVEIAKRASGDLRAAINDLQ 202
I+ R + L Q+ ++ L I++ E + + K+ L+ ++K GD+R IN LQ
Sbjct: 206 IQSRCTRFRFAPLDQKLIVPRLEYIVETEQLKMTPDGKDALLIVSK---GDMRTVINTLQ 262
Query: 203 TVVAGGYEDARYVLAYRDV-EKTVFQALG 230
+ +++ V E TV+Q +G
Sbjct: 263 ST----------AMSFDTVSENTVYQCIG 281
>pir||T50383 homolog to yeast chl12 protein [imported] - fission yeast
(Schizosaccharomyces pombe) >gi|6522992|emb|CAB62096.1|
(AL133306) similar to S. cerevisiae chl12 protein
[Schizosaccharomyces pombe]
Length = 960
Score = 79.6 bits (193), Expect = 7e-14
Identities = 58/246 (23%), Positives = 103/246 (41%), Gaps = 49/246 (19%)
Query: 6 WVEKYRPRRLSEIINQEDAISKVKAWIEAW---------------LHGNP---------- 40
WV+ YRP+ +++ E WI+AW + NP
Sbjct: 353 WVDTYRPQLFRDLLGDERVHRAAMHWIKAWDPCVFGKSRLQPSKSMRFNPRFTNITSDSD 412
Query: 41 -PKKKALLLAGPPGSGKTTTVYALAREYNFEVIELNASDERTYDKIARYVQAAYT-MDIL 98
P K+ ++L G G+GKTT + +A + ++V+E+NASD+RT + V +A + L
Sbjct: 413 RPDKRIMMLTGLAGAGKTTLAHVIAHQAGYKVLEINASDDRTAHTVHEKVSSAISNHSAL 472
Query: 99 GKRRKIIFLDEADNIEPSGAPEIAKLID---------------------RARNPIIMAAN 137
+ + +DE D +P+ + L++ + PII N
Sbjct: 473 SSQPTCVIVDEIDGGDPAFVRALLSLLESDEKATEYSQAGNSKKKKKFKKLCRPIICICN 532
Query: 138 H-YWEVPKEIRDRAELVEYKRLTQRDVINALVRILKREGITVPKEVLVEIAKRASGDLRA 196
Y + +R A+++ ++ Q ++ L I + E I V L + + D+R+
Sbjct: 533 DLYTPALRPLRPYAQIIYFRPPPQASLVGRLRTICRNENIAVDSRSLTLLTDIYNSDIRS 592
Query: 197 AINDLQ 202
IN LQ
Sbjct: 593 CINSLQ 598
>emb|CAB92098.1| (AL356333) Replication factor C 36 KD subunit; activator 1 36 kd
subunit [Schizosaccharomyces pombe]
Length = 142
Score = 79.2 bits (192), Expect = 9e-14
Identities = 44/114 (38%), Positives = 68/114 (59%), Gaps = 12/114 (10%)
Query: 4 VPWVEKYRPRRLSEIINQEDAISKVKAWIEAWLHGNPPKKKALLLAGPPGSGKTTTVYAL 63
+PWVEKYRP L ++++ +D IS ++ +I + + +L GPPG+GKT+T+ A
Sbjct: 23 LPWVEKYRPANLEDVVSHKDIISTLEKFISS------NRVPHMLFYGPPGTGKTSTILAC 76
Query: 64 ARE-----YNFEVIELNASDERTYDKIARYVQ-AAYTMDILGKRRKIIFLDEAD 111
AR+ Y +++ELNASD+R D + ++ A T I K+I LDEAD
Sbjct: 77 ARKIYGPNYRNQLMELNASDDRGIDAVREQIKNFASTRQIFASTFKMIILDEAD 130
>gb|AAG21804.1|AF210454_2 (AF210454) replication factor C subunit 1 [Ectocarpus siliculosus
virus]
Length = 324
Score = 74.9 bits (181), Expect = 2e-12
Identities = 56/222 (25%), Positives = 101/222 (45%), Gaps = 24/222 (10%)
Query: 1 MPEVPWVEKYRPRRLSEIINQEDAISKVKAWIEAWLHGNPPKKKA----LLLAGPPGSGK 56
M PWVEKYRP SE++ + +IS L N K+ LL+ GP G GK
Sbjct: 1 MTAQPWVEKYRPLCFSEVVGNKKSIS---------LLSNLAAKRVSIPHLLICGPSGCGK 51
Query: 57 TTTVYALA-----REYNFEVIELNASDERTYDK----IARYVQAAYTMDILGKRRKIIFL 107
T V L ++ L++ DER D + + + + KI+ L
Sbjct: 52 TVCVDILCNTMIPENRGARMLRLSSFDERGIDNVRTTVKNFARGRVGTEPTPTIAKIVVL 111
Query: 108 DEADNIEPSGAPEIAKLID--RARNPIIMAANHYWEVPKEIRDRAELVEYKRLTQRDVIN 165
DEAD++ P + +++D + I+ N+ ++ + I+ R ++ + ++ +
Sbjct: 112 DEADSMTPGAFQALRRIMDVYSSTTRFIIVCNNSTKIIEPIQSRCAILRFSKVDDAQLRL 171
Query: 166 ALVRILKREGITVPKEVLVEIAKRASGDLRAAINDLQTVVAG 207
+ ++ G+ + +A A GD+R+AIN L ++V+G
Sbjct: 172 RIRQVCDMAGVEYDPGGIGALACVADGDVRSAINSLASIVSG 213
>gb|AAF48768.1| (AE003506) CG8142 gene product [Drosophila melanogaster]
Length = 288
Score = 74.1 bits (179), Expect = 3e-12
Identities = 50/173 (28%), Positives = 84/173 (47%), Gaps = 15/173 (8%)
Query: 46 LLLAGPPGSGKTTTVYALARE-----YNFEVIELNASDERTYDKIARYVQAAYTMDILGK 100
+LL GPPG+GKT+T+ A +R+ + ++ELNASDER + + ++ +
Sbjct: 1 MLLYGPPGTGKTSTILAASRQIFGDMFKDRILELNASDERGINVVRTKIKNFSQLSASSV 60
Query: 101 RR--------KIIFLDEADNIEPSGAPEIAKLIDRARNP--IIMAANHYWEVPKEIRDRA 150
R KII LDEAD++ + + + +++ + N+ + I R
Sbjct: 61 RPDGKPCPPFKIIILDEADSMTHAAQSALRRTMEKESRSTRFCLICNYVSRIIVPITSRC 120
Query: 151 ELVEYKRLTQRDVINALVRILKREGITVPKEVLVEIAKRASGDLRAAINDLQT 203
+K L + VI+ L I + EG+ + + I K + GDLR AI LQ+
Sbjct: 121 SKFRFKALGEDKVIDRLKYICEMEGVKIEDDAYKSIVKISGGDLRRAITTLQS 173
>dbj|BAB03292.1| (AB037375) replication factor C small subunit precursor [Pyrococcus
furiosus]
Length = 268
Score = 73.4 bits (177), Expect = 5e-12
Identities = 53/158 (33%), Positives = 80/158 (50%), Gaps = 8/158 (5%)
Query: 57 TTTVYALARE-----YNFEVIELNASDERTYDKIARYVQA-AYTMDILGKRRKIIFLDEA 110
TT ALARE + +ELNASDER + I V+ A T I G KIIFLDEA
Sbjct: 1 TTAALALARELFGENWRHNFLELNASDERGINVIREKVKEFARTKPIGGASFKIIFLDEA 60
Query: 111 DNIEPSGAPEIAKLIDRARNPI--IMAANHYWEVPKEIRDRAELVEYKRLTQRDVINALV 168
D + + + ++ + + I++ N+ ++ + I+ R + ++ L D+ L
Sbjct: 61 DALTQDAQQALRRTMEMFSSNVRFILSCNYSSKIIEPIQSRCAIFRFRPLRDEDIAKRLR 120
Query: 169 RILKREGITVPKEVLVEIAKRASGDLRAAINDLQTVVA 206
I + EG+ + +E L I A GD+R AIN LQ A
Sbjct: 121 YIAENEGLELTEEGLQAILYIAEGDMRRAINILQAAAA 158
>pir||F71231 probable replication factor C subunit - Pyrococcus horikoshii
>gi|3256498|dbj|BAA29181.1| (AP000001) 855aa long
hypothetical replication factor C subunit [Pyrococcus
horikoshii]
Length = 855
Score = 72.2 bits (174), Expect = 1e-11
Identities = 52/158 (32%), Positives = 80/158 (49%), Gaps = 8/158 (5%)
Query: 57 TTTVYALARE-----YNFEVIELNASDERTYDKIARYVQA-AYTMDILGKRRKIIFLDEA 110
TT AL+RE + +ELNASDER + I V+ A T I G KIIFLDEA
Sbjct: 587 TTAALALSRELFGENWRHNFLELNASDERGINVIREKVKEFARTKPIGGASFKIIFLDEA 646
Query: 111 DNIEPSGAPEIAKLIDRARNPI--IMAANHYWEVPKEIRDRAELVEYKRLTQRDVINALV 168
D + + + ++ + + I++ N+ ++ + I+ R + ++ L D+ L
Sbjct: 647 DALTQDAQQALRRTMEMFSSNVRFILSCNYSSKIIEPIQSRCAIFRFRPLRDEDIAKRLR 706
Query: 169 RILKREGITVPKEVLVEIAKRASGDLRAAINDLQTVVA 206
I + EG+ + +E L I A GD+R AIN LQ A
Sbjct: 707 YIAENEGLELTEEGLQAILYIAEGDMRRAINILQAAAA 744
>gb|AAF52944.1| (AE003628) RfC3 gene product [Drosophila melanogaster]
Length = 297
Score = 71.4 bits (172), Expect = 2e-11
Identities = 48/174 (27%), Positives = 88/174 (49%), Gaps = 9/174 (5%)
Query: 41 PKKKALLLAGPPGSGKTTTVYALAR------EYNFEVIELNASDERTYDKI-ARYVQAAY 93
P LL GPPG+GKT+T+ A AR ++ V+ELNASD+R + + + A
Sbjct: 7 PALPHLLFYGPPGTGKTSTILACARQLYSPQQFKSMVLELNASDDRGIGIVRGQILNFAS 66
Query: 94 TMDILGKRRKIIFLDEADNIEPSGAPEIAKLIDRARNPI--IMAANHYWEVPKEIRDRAE 151
T I K+I LDEAD + + ++I++ + + + N+ ++ ++ R
Sbjct: 67 TRTIFCDTFKLIILDEADAMTNDAQNALRRIIEKYTDNVRFCVICNYLSKIIPALQSRCT 126
Query: 152 LVEYKRLTQRDVINALVRILKREGITVPKEVLVEIAKRASGDLRAAINDLQTVV 205
+ L+Q ++ L +I++ E + + ++ + A GD+R +N LQ+ V
Sbjct: 127 RFRFAPLSQDQMMPRLEKIIEAEAVQITEDGKRALLTLAKGDMRKVLNVLQSTV 180
>emb|CAB93386.1| (AL357523) conserved ATP/GTP binding protein [Streptomyces
coelicolor A3(2)]
Length = 451
Score = 71.0 bits (171), Expect = 3e-11
Identities = 59/234 (25%), Positives = 103/234 (43%), Gaps = 12/234 (5%)
Query: 5 PWVEKYRPRRLSEIINQEDAI---SKVKAWIEAWLHGNPPKKKALLLAGPPGSGKTTTVY 61
P + RPR L E++ Q+ + S ++ + G P +++L GPPG+GKTT Y
Sbjct: 22 PLAVRMRPRTLDEVVGQQHLLKPGSPLRRLVGEGASG-PAGPSSVILWGPPGTGKTTLAY 80
Query: 62 ALAREYNFEVIELNASDERTYDKIARYVQAAYTMDILGKRRKIIFLDEADNIEPSGAPEI 121
+++ N +EL+A + A A + GK ++FLDE + +
Sbjct: 81 VVSKATNKRFVELSAITAGVKEVRAVIDGARRAVGGYGK-ETVLFLDEIHRFSKAQQDSL 139
Query: 122 AKLIDRARNPIIMAA--NHYWEVPKEIRDRAELVEYKRLTQRDVINALVRILKRE----- 174
++ +I A N Y+ V + R+ L+ + LT DV + L R L E
Sbjct: 140 LPAVENRWVTLIAATTENPYFSVISPLLSRSLLLTLEPLTDDDVRDLLRRALTDERGLKG 199
Query: 175 GITVPKEVLVEIAKRASGDLRAAINDLQTVVAGGYEDARYVLAYRDVEKTVFQA 228
+T+P + + + A GD R A+ L+ + + +E+TV +A
Sbjct: 200 AVTLPGDTEEHLLRIAGGDARRALTALEAAAGAALDKGEAEVGLTTLEETVDRA 253
>pir||C75339 conserved hypothetical protein - Deinococcus radiodurans (strain
R1) >gi|6459682|gb|AAF11452.1|AE002029_1 (AE002029)
conserved hypothetical protein [Deinococcus radiodurans]
Length = 434
Score = 69.5 bits (167), Expect = 8e-11
Identities = 65/235 (27%), Positives = 96/235 (40%), Gaps = 20/235 (8%)
Query: 2 PEVPWVEKYRPRRLSEIINQEDAISKVKAWIEAWLHGNPPKKKALLLAGPPGSGKTTTVY 61
P P E+ RPR ++E+ Q + K G + +L+L GPPG GKTT
Sbjct: 6 PPAPLAERLRPRTVAEVAGQSHLLGAGKPLTRVLQSG---RLGSLILWGPPGVGKTTLAR 62
Query: 62 ALAREYNFEVIELNASDERTYDKIARYVQAAYTMDILGKRRKIIFLDEADNIEPSGAPEI 121
LA E I L+A D R A + RR ++FLDE + +
Sbjct: 63 LLAGEVGAHFIALSAVSAGVKD--VRDAVAEAEREQARGRRTVLFLDEIHRFNKAQQDAL 120
Query: 122 AKLIDRARNPIIMAA--NHYWEVPKEIRDRAELVEYKRLTQRDVINALVRILKRE----G 175
++ +I A N +EV +R RA + + L+ DV+ L R L E G
Sbjct: 121 LPHVESGLLTLIGATTENPSFEVNPALRSRARTLVLEALSPEDVLALLRRALSDERGLPG 180
Query: 176 ITVPKEVLVEIAKRASGDLRAAINDLQTVVAGGYEDARYVLAYRDVEKTVFQALG 230
+ L +A+ A GD R A++ L+ LA E+ V +A G
Sbjct: 181 VEAEDSALELLARLAEGDARRALSTLEVAA---------TLANPVTEEAVTEAFG 226
Database: ./suso.pep
Posted date: Jul 6, 2001 5:57 PM
Number of letters in database: 840,471
Number of sequences in database: 2977
Database: /banques/blast2/nr.pep
Posted date: Dec 14, 2000 12:46 PM
Number of letters in database: 188,266,275
Number of sequences in database: 595,510
Lambda K H
0.315 0.133 0.369
Gapped
Lambda K H
0.270 0.0470 0.230
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 172519391
Number of Sequences: 2977
Number of extensions: 7584890
Number of successful extensions: 219230
Number of sequences better than 1.0e-10: 73
Number of HSP's better than 0.0 without gapping: 7
Number of HSP's successfully gapped in prelim test: 66
Number of HSP's that attempted gapping in prelim test: 218680
Number of HSP's gapped (non-prelim): 176
length of query: 479
length of database: 189,106,746
effective HSP length: 61
effective length of query: 418
effective length of database: 152,599,039
effective search space: 63786398302
effective search space used: 63786398302
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 41 (21.6 bits)
S2: 167 (69.5 bits)