BLASTP 2.0.10 [Aug-26-1999]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= PAB0069 (RfcL) DE:activator 1, replication factor C, large
subunit
         (479 letters)

Database: ./suso.pep; /banques/blast2/nr.pep
           598,487 sequences; 189,106,746 total letters

Searching..................................................done

                                                                   Score     E
Sequences producing significant alignments:                        (bits)  Value

pir||D75198 activator 1, replication factor c, large s ubunit PA...   949  0.0
pir||G71231 probable replication factor C subunit - Pyrococcus h...   818  0.0
dbj|BAA88155.1| (AB034755) replication factor C large subunit [P...   799  0.0
pir||D64410 replication factor C large chain homolog - Methanoco...   328  1e-88
gi|11498795 activator 1, replication factor C, 53 KD subunit [Ar...   285  7e-76
pir||A69130 replication factor C, large subunit - Methanobacteri...   264  1e-69
gb|AAG19883.1| (AE005072) replication factor C large subunit; Rf...   235  9e-61
gb|AAK41066.1| Activator 1, replication factor C (RFC) large sub...   222  5e-57
emb|CAB57534.1| (Y18930) replication factor C, large subunit [Su...   222  5e-57
pir||E72633 probable replication factor C subunit APE1524 - Aero...   194  2e-48
emb|CAC12408.1| (AL445067) replication factor C subunit related ...   178  9e-44
gb|AAF18689.1|AC010795_4 (AC010795) replication factor, putative...   119  6e-26
pir||T37746 activator 1 subunit (replication factor subunit) - f...   119  8e-26
gi|11177922 replication factor C (activator 1) 2 (40kD) [Mus mus...   118  1e-25
sp|P53033|AC14_CHICK ACTIVATOR 1 40 KD SUBUNIT (REPLICATION FACT...   116  4e-25
gi|6324478 Subunit 4 of Replication Factor C; homologous to huma...   116  7e-25
gi|4506487 replication factor C (activator 1) 2 (40kD) [Homo sap...   115  9e-25
pir||A42700 replication factor C - human                              115  1e-24
gi|11499642 activator 1, replication factor C, 35 KD subunit [Ar...   113  3e-24
pir||C72633 probable replication factor C subunit APE1522 - Aero...   112  8e-24
gb|AAK41065.1| Activator 1, replication factor C, small subunit ...   112  1e-23
sp|P53034|AC14_DROME ACTIVATOR 1 40 KDA SUBUNIT (REPLICATION FAC...   112  1e-23
emb|CAB57535.1| (Y18930) activator 1, replication factor C, smal...   112  1e-23
emb|CAA07618.1| (AJ007712) replication factor C subunit [Arxula ...   109  9e-23
gb|AAB88360.1| (AF036699) strong similarity to the activator 1 3...   108  1e-22
pir||B69130 replication factor C, small subunit - Methanobacteri...   106  6e-22
gi|6324039 Subunit 3 of Replication Factor C; homologous to huma...   104  2e-21
gi|6677723 replication factor C (activator 1) 5 (36.5kD) [Homo s...   103  4e-21
gi|4506491 replication factor C (activator 1) 4 (37kD) [Homo sap...   103  4e-21
pir||A45253 activator 1 37K chain - human                             102  8e-21
gb|AAG20394.1| (AE005112) replication factor C small subunit; Rf...    99  7e-20
pir||D71603 replication factor C, 140 kDa subunit (ATPase) PFB08...    99  1e-19
pir||T43410 replication factor C chain Rfc3 - fission yeast  (Sc...    99  1e-19
emb|CAC12618.1| (AL445067) probable replication factor C, 40 KD ...    98  3e-19
dbj|BAB16439.1| (AB038319) replication factor C 36kDa subunit [O...    96  6e-19
pir||H71604 replication factor C, 40 kDa subunit (replication ac...    96  8e-19
gb|AAG37987.1|AF071409_1 (AF071409) replication factor C subunit...    96  8e-19
pir||A49393 activator 1 large chain - mouse >gi|405112|gb|AAA216...    95  2e-18
gb|AAF63387.1|AF247499_1 (AF247499) replication factor C subunit...    94  4e-18
pir||A56284 differentiation-specific element binding protein - m...    93  6e-18
gi|6755306 replication factor C, 140 kDa [Mus musculus] >gi|1703...    93  7e-18
gb|AAF07781.1|AC010704_6 (AC010704) putative replication factor ...    92  9e-18
dbj|BAB16441.1| (AB045677) replication factor C 37kDa subunit [O...    92  9e-18
gb|AAC52140.1| (U07157) ISRE-binding protein [Mus musculus]            92  1e-17
gb|AAD41422.1|AC007727_11 (AC007727) Similar to gb|M87339 replic...    92  2e-17
gb|AAD01890.1| (AF030050) replication factor C [Rattus norvegicus]     91  3e-17
gb|AAG37985.1|AF069296_1 (AF069296) replication factor C3 [Plasm...    90  5e-17
gb|AAC60361.1| (U60144) replication factor C large subunit [Anas...    90  6e-17
pir||D72344 DNA polymerase III, gamma and tau subunit - Thermoto...    90  6e-17
gi|6322528 Subunit 2 of Replication Factor C; homologous to huma...    89  1e-16
gb|AAF69583.1|AC019154_2 (AC019154) Replication Factor C [Leishm...    87  4e-16
gi|4506485 replication factor C (activator 1) 1 (145kD) [Homo sa...    85  2e-15
gi|11435908 replication factor C (activator 1) 1 (145kD) [Homo s...    85  2e-15
sp|P35251|AC15_HUMAN ACTIVATOR 1 140 KDA SUBUNIT (REPLICATION FA...    84  3e-15
sp|Q09843|RFC2_SCHPO PROBABLE ACTIVATOR 1 41 KD SUBUNIT (REPLICA...    84  3e-15
pir||T39941 hypothetical protein SPBC23E6.07c - fission yeast  (...    82  1e-14
gi|6324791 Subunit 1 of Replication Factor C; homologous to huma...    82  1e-14
sp|P35600|GNF1_DROME GERMLINE TRANSCRIPTION FACTOR 1 >gi|304728|...    81  2e-14
gb|AAB58311.1| (U97685) replication factor C large subunit [Dros...    81  2e-14
pir||T18305 replication factor C like protein - Emericella nidul...    81  3e-14
pir||T18306 replication factor C protein - Emericella nidulans >...    81  3e-14
pir||T20230 hypothetical protein C54G10.2 - Caenorhabditis elega...    81  3e-14
sp|P53016|AC12_CAEEL PUTATIVE ACTIVATOR 1 37 KD SUBUNIT (REPLICA...    80  5e-14
sp|P34429|AC11_CAEEL PUTATIVE ACTIVATOR 1 36 KD SUBUNIT (REPLICA...    80  5e-14
pir||T50383 homolog to yeast chl12 protein [imported] - fission ...    80  7e-14
emb|CAB92098.1| (AL356333) Replication factor C 36 KD subunit; a...    79  9e-14
gb|AAG21804.1|AF210454_2 (AF210454) replication factor C subunit...    75  2e-12
gb|AAF48768.1| (AE003506) CG8142 gene product [Drosophila melano...    74  3e-12
dbj|BAB03292.1| (AB037375) replication factor C small subunit pr...    73  5e-12
pir||F71231 probable replication factor C subunit - Pyrococcus h...    72  1e-11
gb|AAF52944.1| (AE003628) RfC3 gene product [Drosophila melanoga...    71  2e-11
emb|CAB93386.1| (AL357523) conserved ATP/GTP binding protein [St...    71  3e-11
pir||C75339 conserved hypothetical protein - Deinococcus radiodu...    69  8e-11

>pir||D75198 activator 1, replication factor c, large s ubunit PAB0069 -
           Pyrococcus abyssi (strain Orsay)
           >gi|5457544|emb|CAB49035.1| (AJ248283) activator 1,
           replication factor C, large s ubunit [Pyrococcus abyssi]
           Length = 479
           
 Score =  949 bits (2427), Expect = 0.0
 Identities = 479/479 (100%), Positives = 479/479 (100%)

Query: 1   MPEVPWVEKYRPRRLSEIINQEDAISKVKAWIEAWLHGNPPKKKALLLAGPPGSGKTTTV 60
           MPEVPWVEKYRPRRLSEIINQEDAISKVKAWIEAWLHGNPPKKKALLLAGPPGSGKTTTV
Sbjct: 1   MPEVPWVEKYRPRRLSEIINQEDAISKVKAWIEAWLHGNPPKKKALLLAGPPGSGKTTTV 60

Query: 61  YALAREYNFEVIELNASDERTYDKIARYVQAAYTMDILGKRRKIIFLDEADNIEPSGAPE 120
           YALAREYNFEVIELNASDERTYDKIARYVQAAYTMDILGKRRKIIFLDEADNIEPSGAPE
Sbjct: 61  YALAREYNFEVIELNASDERTYDKIARYVQAAYTMDILGKRRKIIFLDEADNIEPSGAPE 120

Query: 121 IAKLIDRARNPIIMAANHYWEVPKEIRDRAELVEYKRLTQRDVINALVRILKREGITVPK 180
           IAKLIDRARNPIIMAANHYWEVPKEIRDRAELVEYKRLTQRDVINALVRILKREGITVPK
Sbjct: 121 IAKLIDRARNPIIMAANHYWEVPKEIRDRAELVEYKRLTQRDVINALVRILKREGITVPK 180

Query: 181 EVLVEIAKRASGDLRAAINDLQTVVAGGYEDARYVLAYRDVEKTVFQALGLVFASDNAKR 240
           EVLVEIAKRASGDLRAAINDLQTVVAGGYEDARYVLAYRDVEKTVFQALGLVFASDNAKR
Sbjct: 181 EVLVEIAKRASGDLRAAINDLQTVVAGGYEDARYVLAYRDVEKTVFQALGLVFASDNAKR 240

Query: 241 AKLAMMNLDMSPDEFLLWIDENIPHMYLKPEEMARAYEAISKADIYLGRAQRTGNYSLWR 300
           AKLAMMNLDMSPDEFLLWIDENIPHMYLKPEEMARAYEAISKADIYLGRAQRTGNYSLWR
Sbjct: 241 AKLAMMNLDMSPDEFLLWIDENIPHMYLKPEEMARAYEAISKADIYLGRAQRTGNYSLWR 300

Query: 301 YAIDMMTAGVAVAGTKKRGFAKFYPPNTLKMLAESKEERSTRNSIIKKIMSEMHMSKLEA 360
           YAIDMMTAGVAVAGTKKRGFAKFYPPNTLKMLAESKEERSTRNSIIKKIMSEMHMSKLEA
Sbjct: 301 YAIDMMTAGVAVAGTKKRGFAKFYPPNTLKMLAESKEERSTRNSIIKKIMSEMHMSKLEA 360

Query: 361 IETMKIIKTIFEKNLDLAAHFTVFLGLSEKEVEFLAGRENAGTIWGKALAIRRKLKKEEE 420
           IETMKIIKTIFEKNLDLAAHFTVFLGLSEKEVEFLAGRENAGTIWGKALAIRRKLKKEEE
Sbjct: 361 IETMKIIKTIFEKNLDLAAHFTVFLGLSEKEVEFLAGRENAGTIWGKALAIRRKLKKEEE 420

Query: 421 KIRKERKEEEKVEVREEKPEEKVEEKREERETKKEKEKKEEKKAEKKGKQVTLFDFIKK 479
           KIRKERKEEEKVEVREEKPEEKVEEKREERETKKEKEKKEEKKAEKKGKQVTLFDFIKK
Sbjct: 421 KIRKERKEEEKVEVREEKPEEKVEEKREERETKKEKEKKEEKKAEKKGKQVTLFDFIKK 479


>pir||G71231 probable replication factor C subunit - Pyrococcus horikoshii
           >gi|3256499|dbj|BAA29182.1| (AP000001) 468aa long
           hypothetical replication factor C subunit [Pyrococcus
           horikoshii]
           Length = 468
           
 Score =  818 bits (2089), Expect = 0.0
 Identities = 405/480 (84%), Positives = 447/480 (92%), Gaps = 14/480 (2%)

Query: 1   MPEVPWVEKYRPRRLSEIINQEDAISKVKAWIEAWLHGNPPKKKALLLAGPPGSGKTTTV 60
           MP+VPW+EKYRPR+LSEI+NQE A+ KV+AWIE+WLHGNPPKKKALLLAGPPGSGKTTTV
Sbjct: 1   MPDVPWIEKYRPRKLSEIVNQEQALEKVRAWIESWLHGNPPKKKALLLAGPPGSGKTTTV 60

Query: 61  YALAREYNFEVIELNASDERTYDKIARYVQAAYTMDILGKRRKIIFLDEADNIEPSGAPE 120
           YALA EYNFEVIELNASDERTY+KIARYVQAAYTMDI+GKRRKIIFLDEADNIEPSGAPE
Sbjct: 61  YALAHEYNFEVIELNASDERTYNKIARYVQAAYTMDIMGKRRKIIFLDEADNIEPSGAPE 120

Query: 121 IAKLIDRARNPIIMAANHYWEVPKEIRDRAELVEYKRLTQRDVINALVRILKREGITVPK 180
           IAKLID+ARNPIIMAANHYWEVPKEIRDRAELVEYKRL QRDVI+ALVRILKREGITVPK
Sbjct: 121 IAKLIDKARNPIIMAANHYWEVPKEIRDRAELVEYKRLNQRDVISALVRILKREGITVPK 180

Query: 181 EVLVEIAKRASGDLRAAINDLQTVVAGGYEDARYVLAYRDVEKTVFQALGLVFASDNAKR 240
           E+L EIAKR+SGDLRAAINDLQT+VAGGYEDA+YVLAYRDVEKTVFQ+LG+VF+SDNAKR
Sbjct: 181 EILTEIAKRSSGDLRAAINDLQTIVAGGYEDAKYVLAYRDVEKTVFQSLGMVFSSDNAKR 240

Query: 241 AKLAMMNLDMSPDEFLLWIDENIPHMYLKPEEMARAYEAISKADIYLGRAQRTGNYSLWR 300
           AKLA+MNLDMSPDEFLLW+DENIPHMYLKPEEMARAYEAIS+ADIYLGRAQRTGNYSLW+
Sbjct: 241 AKLALMNLDMSPDEFLLWVDENIPHMYLKPEEMARAYEAISRADIYLGRAQRTGNYSLWK 300

Query: 301 YAIDMMTAGVAVAGTKKRGFAKFYPPNTLKMLAESKEERSTRNSIIKKIMSEMHMSKLEA 360
           YAIDMMTAGVAVAGTKK+GFAKFYPPNTLKMLAESKEERS R+SIIKKIM EMHMSKLEA
Sbjct: 301 YAIDMMTAGVAVAGTKKKGFAKFYPPNTLKMLAESKEERSIRDSIIKKIMKEMHMSKLEA 360

Query: 361 IETMKIIKTIFEKNLDLAAHFTVFLGLSEKEVEFLAGRENAGTIWGKALAIRRKLKKEEE 420
           +ETMKI++TIFE NLDLAAHFTVFL L+EKEVEFLAG+E AGTIWGK L+IRR++     
Sbjct: 361 LETMKILRTIFENNLDLAAHFTVFLELTEKEVEFLAGKEKAGTIWGKTLSIRRRI----- 415

Query: 421 KIRKERKEEEKVEVREEKPEEKVEEKREERETKKEKEKKEEKKAE-KKGKQVTLFDFIKK 479
                 KE EK+E  E+  EEKVEE+  E E ++E++++E+ KAE KKGKQVTLFDFIKK
Sbjct: 416 ------KETEKIE--EKAVEEKVEEEEAEEEEEEERKEEEKPKAEKKKGKQVTLFDFIKK 467


>dbj|BAA88155.1| (AB034755) replication factor C large subunit [Pyrococcus furiosus]
           Length = 479
           
 Score =  799 bits (2040), Expect = 0.0
 Identities = 397/482 (82%), Positives = 443/482 (91%), Gaps = 6/482 (1%)

Query: 1   MPEVPWVEKYRPRRLSEIINQEDAISKVKAWIEAWLHGNPPKKKALLLAGPPGSGKTTTV 60
           MPE+PWVEKYRP++LSEI+NQE+AI KV+AWIE+WLHG+PPKKKALLLAGPPGSGKTTTV
Sbjct: 1   MPELPWVEKYRPKKLSEIVNQEEAIEKVRAWIESWLHGHPPKKKALLLAGPPGSGKTTTV 60

Query: 61  YALAREYNFEVIELNASDERTYDKIARYVQAAYTMDILGKRRKIIFLDEADNIEPSGAPE 120
           YALA EYNFEVIELNASDERTY+KI+RYVQAAYTMDILGKRRKIIFLDEADNIEPSGA E
Sbjct: 61  YALANEYNFEVIELNASDERTYEKISRYVQAAYTMDILGKRRKIIFLDEADNIEPSGAKE 120

Query: 121 IAKLIDRARNPIIMAANHYWEVPKEIRDRAELVEYKRLTQRDVINALVRILKREGITVPK 180
           IAKLID+A+NPIIMAAN YWEVPKEIR++AELVEYKRLTQRDV+NAL+RILKREGITVPK
Sbjct: 121 IAKLIDKAKNPIIMAANKYWEVPKEIREKAELVEYKRLTQRDVMNALIRILKREGITVPK 180

Query: 181 EVLVEIAKRASGDLRAAINDLQTVVAGGYEDARYVLAYRDVEKTVFQALGLVFASDNAKR 240
           E+L+EIAKR+SGDLRAAINDLQTVV GGYEDA  VLAYRDVEKTVFQALGLVF SDNAKR
Sbjct: 181 EILLEIAKRSSGDLRAAINDLQTVVVGGYEDATQVLAYRDVEKTVFQALGLVFGSDNAKR 240

Query: 241 AKLAMMNLDMSPDEFLLWIDENIPHMYLKPEEMARAYEAISKADIYLGRAQRTGNYSLWR 300
           AK+AM NLDMSPDEFLLW+DENIPH+YL PEE+A+AY+AIS+ADIYLGRA RTGNYSLW+
Sbjct: 241 AKMAMWNLDMSPDEFLLWVDENIPHLYLNPEEIAQAYDAISRADIYLGRAARTGNYSLWK 300

Query: 301 YAIDMMTAGVAVAGTKKRGFAKFYPPNTLKMLAESKEERSTRNSIIKKIMSEMHMSKLEA 360
           YAIDMMTAGVAVAG K+RGF KFYPPNTLK+LAESKEER  R SIIKKI+ EMHMS+L+A
Sbjct: 301 YAIDMMTAGVAVAGRKRRGFVKFYPPNTLKILAESKEEREIRESIIKKIIREMHMSRLQA 360

Query: 361 IETMKIIKTIFEKNLDLAAHFTVFLGLSEKEVEFLAGRENAGTIWGKALAIRRKLKKEEE 420
           IETMKII+ IFE NLDLAAHFTVFLGLSEKEVEFLAG+E AGTIWGKALA+RRKLK  E 
Sbjct: 361 IETMKIIREIFENNLDLAAHFTVFLGLSEKEVEFLAGKEKAGTIWGKALALRRKLK--EL 418

Query: 421 KIRKERKEEEKVEVREEKPEEKVEEKREERETKKEKEKKEEKKAE---KKGKQVTLFDFI 477
            IR+E K + ++E  EE+ EEK EE++EE E K E+EK+EEKK +   KKGKQ TLFDF+
Sbjct: 419 GIREEEKPKVEIE-EEEEEEEKTEEEKEEIEEKPEEEKEEEKKEKEKPKKGKQATLFDFL 477

Query: 478 KK 479
           KK
Sbjct: 478 KK 479


>pir||D64410 replication factor C large chain homolog - Methanococcus jannaschii
           >gi|1591562|gb|AAB98888.1| (U67532) activator 1
           (replication factor C), 53 KD subunit [Methanococcus
           jannaschii]
           Length = 516
           
 Score =  328 bits (831), Expect = 1e-88
 Identities = 204/517 (39%), Positives = 293/517 (56%), Gaps = 48/517 (9%)

Query: 6   WVEKYRPRRLSEIINQEDAISKVKAWIEAWLHGNPPKKKALLLAGPPGSGKTTTVYALAR 65
           WVEKYRP+ L ++   E    K+K WIE++L G  PK   +LL GPPG GKTT  YALA 
Sbjct: 4   WVEKYRPKSLKDVAGHEKVKEKLKTWIESYLKGETPKP--ILLVGPPGCGKTTLAYALAN 61

Query: 66  EYNFEVIELNASDERTYDKIARYVQAAYTMDILGKRRKIIFLDEADNI----EPSGAPEI 121
           +Y FEVIELNASD+R    I + V  A T   +  ++ +I LDE D I    +  G  E+
Sbjct: 62  DYGFEVIELNASDKRNSSAIKKVVGHAATSSSIFGKKFLIVLDEVDGISGKEDAGGVSEL 121

Query: 122 AKLIDRARNPIIMAANH-YWEVPKEIRDRAELVEYKRLTQRDVINALVRILKREGITVPK 180
            K+I +A+NPII+ AN  Y    + +    E+++   +    V   L +I ++EG+ V  
Sbjct: 122 IKVIKKAKNPIILTANDAYAPSIRSLLPYVEVIQLNPVHTNSVYKVLKKIAEKEGLDVDD 181

Query: 181 EVLVEIAKRASGDLRAAINDLQTVVAGG---YEDARYVLAYRDVEKTVFQALGLVFASDN 237
           + L  IA+ ++GDLR+AINDL+ +   G   YE A+  L  R  E  +F AL ++  + +
Sbjct: 182 KTLKMIAQHSAGDLRSAINDLEALALSGDLSYEAAQK-LPDRKREANIFDALRVILKTTH 240

Query: 238 AKRAKLAMMNLDMSPDEFLLWIDENIPHMYLKPEEMARAYEAISKADIYLGRAQRTGNYS 297
              A  A+MN+D +PD  + WI EN+P  Y KPEE+ARA+E +SKAD YLGR  R  NYS
Sbjct: 241 YGIATTALMNVDETPDVVIEWIAENVPKEYEKPEEVARAFEYLSKADRYLGRVMRRQNYS 300

Query: 298 LWRYAIDMMTAGVAVAGTKK-RGFAKFYPPNTLKMLAESKEERSTRNSIIKKIMSEMHMS 356
            W+YA  +MTAGVA++  +K R +  +  P   ++L ++K ER   N I+KKI  + H S
Sbjct: 301 FWKYATTLMTAGVALSKDEKYRKWTPYSYPKIFRLLTKTKAEREILNKILKKIGEKTHTS 360

Query: 357 KLEAIETMKIIKTIFEKNLDLAAHFTVFLGLSEKEVEFLAGRENAG---TIWGKALAIRR 413
              A   ++++K + ++N  +AA    +  + E E++ L G + A     I  +   + R
Sbjct: 361 SKRARFDLQMLKLLAKENPSVAADLVDYFEIKEDELKVLVGDKLASEILKILKEKKKLER 420

Query: 414 KLKKEEEKIRKERKEEEKV--------------------------EVRE---EKP---EE 441
           K KKE+EK+ KE+K+EEK                           EV+E   EKP   E 
Sbjct: 421 KKKKEKEKLEKEKKKEEKAKEKQSNLIIQPKEIKEEVKAEVEKKEEVKEKIVEKPKAEEV 480

Query: 442 KVEEKREERETKKEKEKKEEKKAEKKGKQVTLFDFIK 478
           K + K EE+ETKK+K KK +KK E KGKQ+TL  F K
Sbjct: 481 KEKSKTEEKETKKDK-KKGKKKKEDKGKQLTLDAFFK 516


>gi|11498795 activator 1, replication factor C, 53 KD subunit [Archaeoglobus
           fulgidus] >gi|7450123|pir||B69399 activator 1,
           replication factor C, 53 KD subunit homolog -
           Archaeoglobus fulgidus >gi|2649392|gb|AAB90051.1|
           (AE001022) activator 1, replication factor C, 53 KD
           subunit [Archaeoglobus fulgidus]
           Length = 479
           
 Score =  285 bits (722), Expect = 7e-76
 Identities = 184/492 (37%), Positives = 274/492 (55%), Gaps = 38/492 (7%)

Query: 6   WVEKYRPRRLSEIINQEDAISKVKAWIEAWLHGNPPKKKALLLAGPPGSGKTTTVYALAR 65
           WVEKYRP+ L E++  +  I++V  W ++W  G+ P    LLLAGPPG GKT+   ALA 
Sbjct: 3   WVEKYRPKTLEEVVADKSIITRVIKWAKSWKRGSKP----LLLAGPPGVGKTSLALALAN 58

Query: 66  EYNFEVIELNASDERTYDKIARYV-----------QAAYTMDILGKRRKIIFLDEADNI- 113
              +E +ELNASD+R++  I R V           +  +    +GK  K+I LDE DNI 
Sbjct: 59  TMGWEAVELNASDQRSWRVIERIVGEGAFNETISDEGEFLSSRIGKL-KLIILDEVDNIH 117

Query: 114 ---EPSGAPEIAKLIDRA-RNPIIMAANHYWEVPKEIRDRAELVEYKRLTQRDVINALVR 169
              +  G   + +LI R    P+I+ AN  +++  E+R+  E++ +KRLT++ V   L R
Sbjct: 118 KKEDVGGEAALIRLIKRKPAQPLILIANDPYKLSPELRNLCEMINFKRLTKQQVARVLER 177

Query: 170 ILKREGITVPKEVLVEIAKRASGDLRAAINDLQTVVAGGYE--DARYVLAYRDVEKTVFQ 227
           I  +EGI V K VL++IA+ A GDLRAAIND Q +  G  E       L  R  EK +F+
Sbjct: 178 IALKEGIKVDKSVLLKIAENAGGDLRAAINDFQALAEGKEELKPEDVFLTKRTQEKDIFR 237

Query: 228 ALGLVFASDNAKRAKLAMMNLDMSPDEFLLWIDENIPHMYLKPEEMARAYEAISKADIYL 287
            + ++F + N      AM+ LD SP++ + W+DEN+P  Y    E+  AYEA+S+ADI+L
Sbjct: 238 VMQMIFKTKNPAVYNEAML-LDESPEDVIHWVDENLPLEY-SGVELVNAYEALSRADIFL 295

Query: 288 GRAQRTGNYSLWRYAIDMMTAGVA-VAGTKKRGFAKFYPPNTLKMLAESKEERSTRNSII 346
           GR +R   Y LW+YA  +MT GV  +    K+GF ++  P   +ML + +++R     I+
Sbjct: 296 GRVRRRQFYRLWKYASYLMTVGVQQMKEEPKKGFTRYRRPAVWQMLFQLRQKREMTRKIL 355

Query: 347 KKIMSEMHMSKLEA-IETMKIIKTIF-EKNLDLAAHFTVFLGLSEKEVEFLAGRENAGTI 404
           +KI    H+S  +A  E   +IK +  E ++D AA    F   +++E+EFL G E    I
Sbjct: 356 EKIGKYSHLSMRKARTEMFPVIKLLLKELDVDKAATIAAFYEFTKEELEFLVG-EKGDEI 414

Query: 405 WGKALAIRRKLKKEEEKIRKERKEEEKVEVREEKPEEKVEEKREERETKKEKEKKEEKKA 464
           W      +   K    +I  E   E  V+  +E+ EE VEE  EE   K E+E++E +  
Sbjct: 415 W------KYVEKHGMHRIEDETFLESFVKAEKEEKEESVEEVAEE---KPEEEREEPRAR 465

Query: 465 EKKGKQVTLFDF 476
           +K GK +TL  F
Sbjct: 466 KKAGKNLTLDSF 477


>pir||A69130 replication factor C, large subunit - Methanobacterium
           thermoautotrophicum (strain Delta H)
           >gi|2621289|gb|AAB84746.1| (AE000811) replication factor
           C, large subunit  [Methanobacterium thermoautotrophicum]
           Length = 479
           
 Score =  264 bits (668), Expect = 1e-69
 Identities = 162/489 (33%), Positives = 273/489 (55%), Gaps = 31/489 (6%)

Query: 6   WVEKYRPRRLSEIINQEDAISKVKAWIEAWLHGNPPKKKALLLAGPPGSGKTTTVYALAR 65
           W EKYRP    E++  +  I+++K WI+AW  G P  +K LLL GPPG+GKTT  + + +
Sbjct: 3   WTEKYRPGSFDEVVGNQKVIAEIKEWIKAWKAGKP--QKPLLLVGPPGTGKTTLAHIIGK 60

Query: 66  EYNFEVIELNASDERTYDKIARYV-QAAYTMDILGKRRKIIFLDEADNI----EPSGAPE 120
           E++ + +ELNASD R+ D + R   +A+ T  +     K+I LDE D I    +  G   
Sbjct: 61  EFS-DTLELNASDRRSQDALMRSAGEASATRSLFNHDLKLIILDEVDGIHGNEDRGGVQA 119

Query: 121 IAKLIDRARNPIIMAANH-YWEVPKEIRDRAELVEYKRLTQRDVINALVRILKREGITVP 179
           I ++I  +R+P+++ AN  Y +  + I+ R  ++  +++    +  AL RI + EGI  P
Sbjct: 120 INRIIKESRHPMVLTANDPYSKRLQSIKPRCRVLNLRKVHTSSIAAALRRICRAEGIECP 179

Query: 180 KEVLVEIAKRASGDLRAAINDLQTVVAGGYEDARYVLAY--RDVEKTVFQALGLVFASDN 237
            +VL E+AKR+ GDLR+AINDL+ +  G       +L    +D    +F A+  V  S +
Sbjct: 180 DDVLRELAKRSRGDLRSAINDLEAMAEGEERIGEELLKMGEKDATSNLFDAVRAVLKSRD 239

Query: 238 AKRAKLAMMNLDMSPDEFLLWIDENIPHMYLKPEEMARAYEAISKADIYLGRAQRTGNYS 297
             + + AM  +D  P   L +I EN+P  Y KP E++RAY+ +S+ADI+ GRA RT NY+
Sbjct: 240 VSKVREAM-RVDDDPTLVLEFIAENVPREYEKPNEISRAYDMLSRADIFFGRAVRTRNYT 298

Query: 298 LWRYAIDMMTAGVAVAGTKK-RGFAKFYPPNTLKMLAESKEERSTRNSIIKKIMSEMHMS 356
            WRYA ++M  GVA+A  K  R F ++   ++ ++L +++++RS R+S+  K+  +MH+S
Sbjct: 299 YWRYASELMGPGVALAKDKTYRKFVRYTGSSSFRILGKTRKQRSLRDSVAAKMAGKMHIS 358

Query: 357 KLEAIETMKIIKTIFEKNLDLAAHFTVFLGLSEKEVEFLAGRENAGTIWGKALAIRRKLK 416
              AI     ++ +FE N ++A   + FL L ++E++    R+       KA   ++  +
Sbjct: 359 PKVAISMFPYMEILFE-NDEMAYDISEFLELRDEEIKLFRKRKI------KAPKRKKTPR 411

Query: 417 KEEEKI------RKERKEEEKVEVREEKPEEKV---EEKREERETKKEKEKKEEKKAEKK 467
           K E K+      +K++  ++ +  +      K      K+++R   +     ++KK   K
Sbjct: 412 KAEIKVGPLYSQKKDKGADKSINDKATDKSAKTPIKSSKKDDRPRDESSSSSDDKK--PK 469

Query: 468 GKQVTLFDF 476
            KQ +LF F
Sbjct: 470 EKQTSLFQF 478


>gb|AAG19883.1| (AE005072) replication factor C large subunit; RfcB [Halobacterium
           sp. NRC-1]
           Length = 501
           
 Score =  235 bits (593), Expect = 9e-61
 Identities = 140/412 (33%), Positives = 229/412 (54%), Gaps = 28/412 (6%)

Query: 4   VPWVEKYRPRRLSEIINQEDAISKVKAWIEAWLHGNPPKKKALLLAGPPGSGKTTTVYAL 63
           V W EKYRP  LSE+   + A   +  W E W    P  ++A+++ G PG GKT+  +AL
Sbjct: 32  VDWTEKYRPASLSEVRGNDTARDALAEWAETW----PDHREAVVVHGSPGIGKTSAAHAL 87

Query: 64  AREYNFEVIELNASDERTYDKIARYV-QAAYTMDILGKR--RKIIFLDEADN----IEPS 116
           A +  ++V+ELNASD+RT D + R   +AA +  + G    RK++ LDEADN    I+  
Sbjct: 88  ANDAGWDVVELNASDQRTADVVERVAGEAARSGTLTGGSGGRKLVLLDEADNLHGNIDRG 147

Query: 117 GAPEIAKLIDRARNPIIMAANHYWEVPKEIRDRAELVEYKRLTQRDVINALVRILKREGI 176
           G+  I +L+D A  PI++ AN Y+E+   +R     +E++ +++R ++  L  + +RE +
Sbjct: 148 GSAAITRLVDDAPQPIVLVANEYYEMSSSLRSACREIEFRDVSKRSIVPVLRDVCRREDV 207

Query: 177 TVPKEVLVEIAKRASGDLRAAINDLQTVVAGGYEDAR------YVLAYRDVEKTVFQALG 230
           T  ++ L  IA++ +GDLR+A+NDLQ +     E  R       V+  RD  + VF  L 
Sbjct: 208 TYEEDALAAIAEQNAGDLRSAVNDLQALA----EQDRTLTADDVVMGERDRTEGVFDYLD 263

Query: 231 LVFASDNAKRAKLAMMNLDMSPDEFLLWIDENIPHMYLKPEEMARAYEAISKADIYLGRA 290
            V A+ +A+ A  A  ++D +PD+ L W+ +N+P  Y +  E+A AYE +S AD++LGR 
Sbjct: 264 DVIATHSAREALQAAYDVDETPDDLLSWVADNVPKDY-RGGELADAYEFLSNADVWLGRV 322

Query: 291 QRTGNYSLWRYAIDMMTAGVAVAGTKKR-GFAKFYPPNTLKMLAESKEERSTRNSIIKKI 349
           + T NY+ WRYA D + AGVA A      G+ ++ PP+  + L  S+  R  R+ + + I
Sbjct: 323 RATQNYAYWRYATDNVAAGVAAARRHDHGGWTRYGPPSYWRKLGSSRATREKRDYVARHI 382

Query: 350 MS----EMHMSKLEAIETMKIIKTIFEKNLDLAAHFTVFLGLSEKEVEFLAG 397
                  M  ++ + +  ++++ T   KN +L         L  + V F+ G
Sbjct: 383 AETAGCSMATARNDVLPFLRVL-THHCKNRELTVAMAAAYELDTEHVAFVTG 433


>gb|AAK41066.1| Activator 1, replication factor C (RFC) large subunit (rfcL)
           [Sulfolobus solfataricus]
           Length = 405
           
 Score =  222 bits (561), Expect = 5e-57
 Identities = 152/410 (37%), Positives = 231/410 (56%), Gaps = 28/410 (6%)

Query: 4   VPWVEKYRPRRLSEIINQEDAISKVKAWIEAWLHGNPPKKKALLLAGPPGSGKTTTVYAL 63
           + W  KYRPR L ++ NQ+DA  +++ WIE+WL+GN    KA+LL GPPG GKT    AL
Sbjct: 2   IQWFLKYRPRSLKDVENQDDAKKQLQEWIESWLNGNS-NVKAVLLHGPPGVGKTVLAEAL 60

Query: 64  AREYNFEVIELNASDERTYDKIARYVQ-AAYTMDILGKRRKIIFLDEADNI---EPSGAP 119
           A +YNFE++E+NASD R    I    + AA    I G + K+I LDE D I   E +GA 
Sbjct: 61  AHDYNFELLEMNASDSRKLQDIKSIAEKAAVYGSIFGTKGKLILLDEVDGINVREDTGAI 120

Query: 120 E-IAKLIDRARNPIIMAANHYWEVP-KEIRDRAELVEYKRLTQRDVINALVRILKREGIT 177
           + I +LI++ + PIIM AN  W    +E+R++A+++E  +L +  +   L +I + E I 
Sbjct: 121 QGILELIEKTKYPIIMTANDPWNPGLRELRNKAKMIELSKLGKYPLRRILKKICQAEKII 180

Query: 178 VPKEVLVEIAKRASGDLRAAINDLQTVVAGGYEDARYVLA-----YRDVEKTVFQALGLV 232
              E L  I   + GD R AIN LQ  +  GY      L       ++ E   F+ L  +
Sbjct: 181 CDDEALNYIIDSSEGDARYAINILQG-IGEGYGKVTLNLVESLAKRKERELDPFETLRDI 239

Query: 233 FASDNAKRAKLAMMNLDMSPDEFLLWIDENIPHMYLKPEEMARAYEAISKADIYLGRAQR 292
           F +  A +AK A  +  +  D  + WI ENIP  Y   E++ RA++A+S+A I+L RA +
Sbjct: 240 FWARYAWQAKNAATSAQIDYDMLIRWISENIPIQYDNIEDIWRAFDALSRASIFLKRA-K 298

Query: 293 TGNYSLWRYAIDMMTAGVAVAGTKKR------GFAKFYPPNTLKMLAESKEERSTRNSII 346
           +G++ L  YA DMM++GVA A  +K+       + K+  P+ +++L++SK+ R TR+ II
Sbjct: 299 SGDWDLLSYAYDMMSSGVAFAEPEKKKPNWKPKWKKYQFPSYIQLLSKSKDIRDTRDEII 358

Query: 347 KKIMSEMHMSKLEAIETMKIIKTIFEKNLDLAAHFTVFLGLSEKEVEFLA 396
           KK+   +H S  +A+        +F K  D        L L+ KE E+L+
Sbjct: 359 KKL--AIHSSFNKALNDTYPFFLLFYKKYD------KHLNLNTKEKEYLS 400


>emb|CAB57534.1| (Y18930) replication factor C, large subunit [Sulfolobus
           solfataricus]
           Length = 405
           
 Score =  222 bits (561), Expect = 5e-57
 Identities = 152/410 (37%), Positives = 231/410 (56%), Gaps = 28/410 (6%)

Query: 4   VPWVEKYRPRRLSEIINQEDAISKVKAWIEAWLHGNPPKKKALLLAGPPGSGKTTTVYAL 63
           + W  KYRPR L ++ NQ+DA  +++ WIE+WL+GN    KA+LL GPPG GKT    AL
Sbjct: 2   IQWFLKYRPRSLKDVENQDDAKKQLQEWIESWLNGNS-NVKAVLLHGPPGVGKTVLAEAL 60

Query: 64  AREYNFEVIELNASDERTYDKIARYVQ-AAYTMDILGKRRKIIFLDEADNI---EPSGAP 119
           A +YNFE++E+NASD R    I    + AA    I G + K+I LDE D I   E +GA 
Sbjct: 61  AHDYNFELLEMNASDSRKLQDIKSIAEKAAVYGSIFGTKGKLILLDEVDGINVREDTGAI 120

Query: 120 E-IAKLIDRARNPIIMAANHYWEVP-KEIRDRAELVEYKRLTQRDVINALVRILKREGIT 177
           + I +LI++ + PIIM AN  W    +E+R++A+++E  +L +  +   L +I + E I 
Sbjct: 121 QGILELIEKTKYPIIMTANDPWNPGLRELRNKAKMIELSKLGKYPLRRILKKICQAEKII 180

Query: 178 VPKEVLVEIAKRASGDLRAAINDLQTVVAGGYEDARYVLA-----YRDVEKTVFQALGLV 232
              E L  I   + GD R AIN LQ  +  GY      L       ++ E   F+ L  +
Sbjct: 181 CDDEALNYIIDSSEGDARYAINILQG-IGEGYGKVTLNLVESLAKRKERELDPFETLRDI 239

Query: 233 FASDNAKRAKLAMMNLDMSPDEFLLWIDENIPHMYLKPEEMARAYEAISKADIYLGRAQR 292
           F +  A +AK A  +  +  D  + WI ENIP  Y   E++ RA++A+S+A I+L RA +
Sbjct: 240 FWARYAWQAKNAATSAQIDYDMLIRWISENIPIQYDNIEDIWRAFDALSRASIFLKRA-K 298

Query: 293 TGNYSLWRYAIDMMTAGVAVAGTKKR------GFAKFYPPNTLKMLAESKEERSTRNSII 346
           +G++ L  YA DMM++GVA A  +K+       + K+  P+ +++L++SK+ R TR+ II
Sbjct: 299 SGDWDLLSYAYDMMSSGVAFAEPEKKKPNWKPKWKKYQFPSYIQLLSKSKDIRDTRDEII 358

Query: 347 KKIMSEMHMSKLEAIETMKIIKTIFEKNLDLAAHFTVFLGLSEKEVEFLA 396
           KK+   +H S  +A+        +F K  D        L L+ KE E+L+
Sbjct: 359 KKL--AIHSSFNKALNDTYPFFLLFYKKYD------KHLNLNTKEKEYLS 400


>pir||E72633 probable replication factor C subunit APE1524 - Aeropyrum pernix
           (strain K1) >gi|5105209|dbj|BAA80523.1| (AP000061) 414aa
           long hypothetical replication factor C subunit
           [Aeropyrum pernix]
           Length = 414
           
 Score =  194 bits (487), Expect = 2e-48
 Identities = 138/407 (33%), Positives = 213/407 (51%), Gaps = 21/407 (5%)

Query: 62  ALAREYNFEVIELNASDERTYDKIARYVQAAYTMDILGKRRKIIFLDEADNIEP----SG 117
           A+A E+N E+IELNASD R    I R V AA     + KR  +I LDE D I P     G
Sbjct: 3   AIASEFNLEMIELNASDYRRRSDIERIVGAASRKRSMFKRGVVILLDEVDGINPREDAGG 62

Query: 118 APEIAKLIDRARNPIIMAANHYW-EVPKEIRDRAELVEYKRLTQRDVINALVRILKREGI 176
              +  +I    NPI+M AN  W +  + +R+ + +VE++ LT   ++  L RI + E I
Sbjct: 63  IEALLSVIKTTENPIVMTANDPWKDFLRPLREVSLMVEFRPLTLTHIVAVLQRICEAERI 122

Query: 177 TVPKEVLVEIAKRASGDLRAAINDLQTVVAGGYED-----ARYVLAYRDVEKTVFQALGL 231
              +E L  IA+R+ GDLR+AINDLQ V A GY       AR ++  R+    +++ L  
Sbjct: 123 ECEREALRYIAERSEGDLRSAINDLQAV-AEGYGRVTLTLAREIVRGREKSIDIWRTLNQ 181

Query: 232 VFASDN-AKRAKLAMMNLDMSPDEFLLWIDENIPHMYLKPEEMARAYEAISKADIYLGRA 290
           VF     A  A+ A+   +   +E + WI++NIP  Y +P ++ RA++A+++A ++LGRA
Sbjct: 182 VFYKPRQAWMARKAVSQSEKDYEELIAWINDNIPRKYGEPSDLFRAFDALARATVFLGRA 241

Query: 291 QRTGNYSLWRYAIDMMTAGVAVAGTKKRGFAKFYP-PNTLKMLAESKEERSTRNSIIKKI 349
           +  GN+ L  Y  D+M  GVA A  +       Y  P  ++M+A+ +  R TR  + + +
Sbjct: 242 KFGGNWELLSYVFDLMGPGVAYARMEGEVLKTRYSYPEKIRMMAQLRGVRETREKLAEVL 301

Query: 350 MSEMHMSKLEA-IETMKIIKTIFEKNLD--LAAHFTVFLGLSEKEVEFLAGRENAGTIWG 406
              + MS+     E + I+  IF  + D    A   +  GL+EK VE LAG+  +  +  
Sbjct: 302 AKRLLMSRRAVKTEVLPILHYIFRSSRDPTKPAMIALEYGLTEKMVELLAGQRKSEIL-- 359

Query: 407 KALAIRRKLKKEEEKIRKERKEEEKVEVREEKPEEKVEEKREERETK 453
           KA+A  +K +  E+ +     +E K   R EK       K  +RE K
Sbjct: 360 KAMATVKKARLGEKPL---EPQEAKARRRGEKASRDEGRKAGKRERK 403


>emb|CAC12408.1| (AL445067) replication factor C subunit related protein
           [Thermoplasma acidophilum]
           Length = 418
           
 Score =  178 bits (448), Expect = 9e-44
 Identities = 120/419 (28%), Positives = 206/419 (48%), Gaps = 29/419 (6%)

Query: 6   WVEKYRPRRLSEIINQEDAISKVKAWIEAWLHGNPPKKKALLLAGPPGSGKTTTVYALAR 65
           W +KYRP+ + ++I   +   ++  WIE+W  G P KK++L+L G  G+GKTTT YA+A 
Sbjct: 4   WADKYRPKNIDDVILNSEIRKQITEWIESWKEGIP-KKRSLILYGSQGTGKTTTAYAIAG 62

Query: 66  EYNFEVIELNASDERTYDKI-ARYVQAAYTMDIL---GKR-RKIIFLDEADNI-----EP 115
            +   V+E+NASD+R  D +    + A+   D+     KR  K+I +DEADN+     + 
Sbjct: 63  TFGVPVVEMNASDQRNRDSMRGTALMASLYGDLFVESAKRPSKVILIDEADNMFERGGDT 122

Query: 116 SGAPEIAKLIDRARNPIIMAANHYWEVPK-----EIRDRAELVEYKRLTQ---------- 160
            G  E++K+I  + NPI++  N  +E  K     ++   +  +E K+  +          
Sbjct: 123 GGIYELSKIIKNSANPIVITMNDIFEFRKKNYASDVISASLTIEMKQYGRKLDKNYNEFR 182

Query: 161 RDVINALVRILKREGITVPKEVLVEIAKRASGDLRAAINDLQTVVAGGYEDARYVLAYRD 220
           R++   L+ ILK EG T+P +V+  I  R   D+R+ INDL+     G   +    + RD
Sbjct: 183 RNIKARLIFILKNEGYTLPDQVVDRIIDRNMPDIRSMINDLEASAVSGTNISDQ--SSRD 240

Query: 221 VEKTVFQALGLVFASDNAKRAKLAMMNLDMSPDEFLLWIDENIPHMYLKPEEMARAYEAI 280
           V + V+  +   F   N      ++   D+    ++ WIDEN+P   +  +++  AYE I
Sbjct: 241 VPEIVYYMVDKAFKR-NYDDTLRSIYGSDIDDSYYVSWIDENLPLKTVDLQDLVSAYEVI 299

Query: 281 SKADIYLGRAQRTGNYSLWRYAIDMMTAGVAVAGTKKRGFAKFYPPNTLKMLAESKEERS 340
           S AD  L   +R  +Y L  + +++           K  + K+  P+ +  ++++KE+R 
Sbjct: 300 SYADHILWAMERRRHYELMAFPMEIAGGVAYYIENMKHEYVKYQSPSYISQMSKTKEKRH 359

Query: 341 TRNSIIKKIMSEMHMSKLEAIETMKIIKTIFEKNLDLAAHFTVFLGLSEKEVEFLAGRE 399
              S+  KI   +HM      E +     +++ N  L   F   L L++ E   L   E
Sbjct: 360 AMMSLALKIGLLIHMGAQRTSEDLWFYSLLYQHNEKLRTFFEEKLNLTQGEENVLTRSE 418


>gb|AAF18689.1|AC010795_4 (AC010795) replication factor, putative; 74998-73295 [Arabidopsis
           thaliana]
           Length = 333
           
 Score =  119 bits (296), Expect = 6e-26
 Identities = 75/214 (35%), Positives = 117/214 (54%), Gaps = 19/214 (8%)

Query: 5   PWVEKYRPRRLSEIINQEDAISKVKAWIEAWLHGNPPKKKALLLAGPPGSGKTTTVYALA 64
           PWVEKYRP ++ +I+  EDA+S+++        GN P    L+L+GPPG+GKTT++ ALA
Sbjct: 16  PWVEKYRPSKVVDIVGNEDAVSRLQVIAR---DGNMPN---LILSGPPGTGKTTSILALA 69

Query: 65  RE-----YNFEVIELNASDERTYD----KIARYVQAAYTMDILGKRRKIIFLDEADNIEP 115
            E     Y   V+ELNASD+R  D    KI  + Q   T+     R K++ LDEAD++  
Sbjct: 70  HELLGTNYKEAVLELNASDDRGIDVVRNKIKMFAQKKVTLP--PGRHKVVILDEADSMTS 127

Query: 116 SGAPEIAKLIDRARNP--IIMAANHYWEVPKEIRDRAELVEYKRLTQRDVINALVRILKR 173
                + + I+   N     +A N   ++ + I+ R  LV + RL+ + ++  L+ ++  
Sbjct: 128 GAQQALRRTIEIYSNSTRFALACNTSAKIIEPIQSRCALVRFSRLSDQQILGRLLVVVAA 187

Query: 174 EGITVPKEVLVEIAKRASGDLRAAINDLQTVVAG 207
           E +    E L  I   A GD+R A+N+LQ   +G
Sbjct: 188 EKVPYVPEGLEAIIFTADGDMRQALNNLQATFSG 221


>pir||T37746 activator 1 subunit (replication factor subunit) - fission yeast
           (Schizosaccharomyces pombe) >gi|4106657|emb|CAA22597.1|
           (AL035064) activator 1 subunit (replication factor
           subunit) [Schizosaccharomyces pombe]
           Length = 342
           
 Score =  119 bits (295), Expect = 8e-26
 Identities = 74/214 (34%), Positives = 115/214 (53%), Gaps = 15/214 (7%)

Query: 3   EVPWVEKYRPRRLSEIINQEDAISKVKAWIEAWLHGNPPKKKALLLAGPPGSGKTTTVYA 62
           E+PWVEKYRP  L +I+  E+ I ++K   +    GN P    L+++G PG GKTT++  
Sbjct: 20  ELPWVEKYRPIVLDDIVGNEETIDRLKVIAK---EGNMPH---LVISGMPGIGKTTSILC 73

Query: 63  LARE-----YNFEVIELNASDERTYDKIARYVQAAYTMDIL--GKRRKIIFLDEADNIEP 115
           LA       Y   V+ELNASDER  D +   ++A     ++    R KII LDEAD++  
Sbjct: 74  LAHALLGPAYKEGVLELNASDERGIDVVRNRIKAFAQKKVILPPGRHKIIILDEADSMTA 133

Query: 116 SGAPEIAKLIDRARNP--IIMAANHYWEVPKEIRDRAELVEYKRLTQRDVINALVRILKR 173
                + + ++   N     +A N   ++ + I+ R  ++ Y RLT + V+  L+ I K 
Sbjct: 134 GAQQALRRTMEIYSNTTRFALACNQSNKIIEPIQSRCAILRYSRLTDQQVLQRLLNICKA 193

Query: 174 EGITVPKEVLVEIAKRASGDLRAAINDLQTVVAG 207
           E +    + L  +   A GD+R A+N+LQ+ VAG
Sbjct: 194 EKVNYTDDGLAALIMTAEGDMRQAVNNLQSTVAG 227


>gi|11177922 replication factor C (activator 1) 2 (40kD) [Mus musculus]
           >gi|4972952|gb|AAD34861.1|AF139987_4 (AF139987)
           replication factor C, 40kDa subunit [Mus musculus]
           >gi|9800515|gb|AAF99332.1|AF289664_3 (AF289664) RFC2
           [Mus musculus]
           Length = 349
           
 Score =  118 bits (294), Expect = 1e-25
 Identities = 76/230 (33%), Positives = 125/230 (54%), Gaps = 20/230 (8%)

Query: 3   EVPWVEKYRPRRLSEIINQEDAISKVKAWIEAWLHGNPPKKKALLLAGPPGSGKTTTVYA 62
           E+PWVEKYRP +L+EI+  ED +S+++ +      GN P    +++AGPPG+GKTT++  
Sbjct: 30  ELPWVEKYRPLKLNEIVGNEDTVSRLEVFAR---EGNVPN---IIIAGPPGTGKTTSILC 83

Query: 63  LAREY-----NFEVIELNASDERTYD----KIARYVQAAYTMDILGKRRKIIFLDEADNI 113
           LAR          V+ELNAS++R  D    KI  + Q   T+     R KII LDEAD++
Sbjct: 84  LARALLGPALKDAVLELNASNDRGIDVVRNKIKMFAQQKVTLP--KGRHKIIILDEADSM 141

Query: 114 EPSGAPEIAKLID--RARNPIIMAANHYWEVPKEIRDRAELVEYKRLTQRDVINALVRIL 171
                  + + ++         +A N   ++ + I+ R  ++ Y +LT   V+  L+ ++
Sbjct: 142 TDGAQQALRRTMEIYSKTTRFALACNASDKIIEPIQSRCAVLRYTKLTDAQVLTRLMNVI 201

Query: 172 KREGITVPKEVLVEIAKRASGDLRAAINDLQTVVAG-GYEDARYVLAYRD 220
           ++E +    + L  I   A GD+R A+N+LQ+  +G GY ++  V    D
Sbjct: 202 EKEKVPYTDDGLEAIIFTAQGDMRQALNNLQSTFSGFGYINSENVFKVCD 251


>sp|P53033|AC14_CHICK ACTIVATOR 1 40 KD SUBUNIT (REPLICATION FACTOR C 40 KD SUBUNIT) (A1
           40 KD SUBUNIT) (RF-C 40 KD SUBUNIT) (RFC40)
           >gi|2134397|pir||I50704 replication factor C/activator 1
           subunit - chicken >gi|527669|gb|AAA20552.1| (U12438)
           replication factor C/activator 1 subunit [Gallus gallus]
           Length = 359
           
 Score =  116 bits (289), Expect = 4e-25
 Identities = 71/216 (32%), Positives = 120/216 (54%), Gaps = 19/216 (8%)

Query: 3   EVPWVEKYRPRRLSEIINQEDAISKVKAWIEAWLHGNPPKKKALLLAGPPGSGKTTTVYA 62
           E+PWVEKYRP +L E++  ED +S+++ + +    GN P    +++AGPPG+GKTT++  
Sbjct: 40  ELPWVEKYRPLKLCEVVGNEDTVSRLEVFAK---EGNVPN---IIIAGPPGTGKTTSILC 93

Query: 63  LAREY-----NFEVIELNASDERTYD----KIARYVQAAYTMDILGKRRKIIFLDEADNI 113
           LAR          V+ELNAS++R  D    KI  + Q   T+     R KII LDEAD++
Sbjct: 94  LARALLGPALKDAVLELNASNDRGIDVVRNKIKMFAQQKVTLP--KGRHKIIILDEADSM 151

Query: 114 EPSGAPEIAKLID--RARNPIIMAANHYWEVPKEIRDRAELVEYKRLTQRDVINALVRIL 171
                  + + ++         +A N   ++ + I+ R  ++ Y +LT   ++  L++I+
Sbjct: 152 TDGAQQALRRTMEIYSKTTRFALACNASDKIIEPIQSRCAVLRYTKLTDSQILARLLKIV 211

Query: 172 KREGITVPKEVLVEIAKRASGDLRAAINDLQTVVAG 207
           ++E +    + L  I   A GD+R A+N+LQ+  +G
Sbjct: 212 EKEDVPYTDDGLEAIIFTAQGDMRQALNNLQSTYSG 247


>gi|6324478 Subunit 4 of Replication Factor C; homologous to human RFC 40 kDa
           subunit; Rfc4p [Saccharomyces cerevisiae]
           >gi|730503|sp|P40339|RFC4_YEAST ACTIVATOR 1 37 KD
           SUBUNIT (REPLICATION FACTOR C 37 KD SUBUNIT)
           >gi|626874|pir||A53845 replication factor C chain RFC4
           [validated] - yeast  (Saccharomyces cerevisiae)
           >gi|499704|gb|AAA34970.1| (L20502) 37 kDa subunit
           [Saccharomyces cerevisiae] >gi|600464|emb|CAA58185.1|
           (X83121) orf 00923 [Saccharomyces cerevisiae]
           >gi|841468|gb|AAC49063.1| (U26030) Rfc4p [Saccharomyces
           cerevisiae] >gi|1419942|emb|CAA99106.1| (Z74836) ORF
           YOL094c [Saccharomyces cerevisiae]
           Length = 323
           
 Score =  116 bits (287), Expect = 7e-25
 Identities = 70/214 (32%), Positives = 120/214 (55%), Gaps = 15/214 (7%)

Query: 3   EVPWVEKYRPRRLSEIINQEDAISKVKAWIEAWLHGNPPKKKALLLAGPPGSGKTTTVYA 62
           ++PWVEKYRP+ LS+I+  ++ I +++   +    GN P    ++++G PG GKTT+V+ 
Sbjct: 8   QLPWVEKYRPQVLSDIVGNKETIDRLQQIAK---DGNMPH---MIISGMPGIGKTTSVHC 61

Query: 63  LARE-----YNFEVIELNASDERTYDKIARYVQ--AAYTMDILGKRRKIIFLDEADNIEP 115
           LA E     Y   V+ELNASD+R  D +   ++  A   + +   + KI+ LDEAD++  
Sbjct: 62  LAHELLGRSYADGVLELNASDDRGIDVVRNQIKHFAQKKLHLPPGKHKIVILDEADSMTA 121

Query: 116 SGAPEIAKLIDRARNP--IIMAANHYWEVPKEIRDRAELVEYKRLTQRDVINALVRILKR 173
                + + ++   N      A N   ++ + ++ R  ++ Y +L+  DV+  L++I+K 
Sbjct: 122 GAQQALRRTMELYSNSTRFAFACNQSNKIIEPLQSRCAILRYSKLSDEDVLKRLLQIIKL 181

Query: 174 EGITVPKEVLVEIAKRASGDLRAAINDLQTVVAG 207
           E +    + L  I   A GD+R AIN+LQ+ VAG
Sbjct: 182 EDVKYTNDGLEAIIFTAEGDMRQAINNLQSTVAG 215


>gi|4506487 replication factor C (activator 1) 2 (40kD) [Homo sapiens]
           >gi|11421447|ref|XP_004901.1| replication factor C
           (activator 1) 2 (40kD) [Homo sapiens]
           >gi|2507300|sp|P35250|AC14_HUMAN ACTIVATOR 1 40 KDA
           SUBUNIT (REPLICATION FACTOR C 40 KDA SUBUNIT) (A1 40 KDA
           SUBUNIT) (RF-C 40 KDA SUBUNIT) (RFC40)
           >gi|1590811|gb|AAB09786.1| (M87338) replication factor
           C, 40-kDa subunit [Homo sapiens]
           >gi|2914760|gb|AAC04860.1| (AF045555) replication factor
           C subunit 2 [Homo sapiens]
           Length = 354
           
 Score =  115 bits (286), Expect = 9e-25
 Identities = 70/216 (32%), Positives = 119/216 (54%), Gaps = 19/216 (8%)

Query: 3   EVPWVEKYRPRRLSEIINQEDAISKVKAWIEAWLHGNPPKKKALLLAGPPGSGKTTTVYA 62
           E+PWVEKYRP +L+EI+  ED +S+++ +      GN P    +++AGPPG+GKTT++  
Sbjct: 35  ELPWVEKYRPVKLNEIVGNEDTVSRLEVFAR---EGNVPN---IIIAGPPGTGKTTSILC 88

Query: 63  LAREY-----NFEVIELNASDERTYD----KIARYVQAAYTMDILGKRRKIIFLDEADNI 113
           LAR          ++ELNAS++R  D    KI  + Q   T+     R KII LDEAD++
Sbjct: 89  LARALLGPALKDAMLELNASNDRGIDVVRNKIKMFAQQKVTLP--KGRHKIIILDEADSM 146

Query: 114 EPSGAPEIAKLID--RARNPIIMAANHYWEVPKEIRDRAELVEYKRLTQRDVINALVRIL 171
                  + + ++         +A N   ++ + I+ R  ++ Y +LT   ++  L+ ++
Sbjct: 147 TDGAQQALRRTMEIYSKTTRFALACNASDKIIEPIQSRCAVLRYTKLTDAQILTRLMNVI 206

Query: 172 KREGITVPKEVLVEIAKRASGDLRAAINDLQTVVAG 207
           ++E +    + L  I   A GD+R A+N+LQ+  +G
Sbjct: 207 EKERVPYTDDGLEAIIFTAQGDMRQALNNLQSTFSG 242


>pir||A42700 replication factor C - human
           Length = 353
           
 Score =  115 bits (285), Expect = 1e-24
 Identities = 70/215 (32%), Positives = 119/215 (54%), Gaps = 18/215 (8%)

Query: 3   EVPWVEKYRPRRLSEIINQEDAISKVKAWIEAWLHGNPPKKKALLLAGPPGSGKTTTVYA 62
           E+PWVEKYRP +L+EI+  ED +S+++ +      GN P    +++AGPPG+GKTT++  
Sbjct: 35  ELPWVEKYRPVKLNEIVGNEDTMSRLEVFAR---EGNVPN---IIIAGPPGTGKTTSILC 88

Query: 63  LAREY----NFEVIELNASDERTYD----KIARYVQAAYTMDILGKRRKIIFLDEADNIE 114
           LAR         ++ELNAS++R  D    KI  + Q   T+     R KII LDEAD++ 
Sbjct: 89  LARALLGALKDAMLELNASNDRGIDVVRNKIKMFAQQKVTLP--KGRHKIIILDEADSMT 146

Query: 115 PSGAPEIAKLID--RARNPIIMAANHYWEVPKEIRDRAELVEYKRLTQRDVINALVRILK 172
                 + + ++         +A N   ++ + I+ R  ++ Y +LT   ++  L+ +++
Sbjct: 147 DGAQQALRRTMEIYSKTTRFALACNASDKIIEPIQSRCAVLRYTKLTDAQILTRLMNVIE 206

Query: 173 REGITVPKEVLVEIAKRASGDLRAAINDLQTVVAG 207
           +E +    + L  I   A GD+R A+N+LQ+  +G
Sbjct: 207 KERVPYTDDGLEAIIFTAQGDMRQALNNLQSTFSG 241


>gi|11499642 activator 1, replication factor C, 35 KD subunit [Archaeoglobus
           fulgidus] >gi|7444552|pir||C69507 activator 1,
           replication factor C, 35 KD subunit homolog -
           Archaeoglobus fulgidus >gi|2648471|gb|AAB89191.1|
           (AE000961) activator 1, replication factor C, 35 KD
           subunit [Archaeoglobus fulgidus]
           Length = 319
           
 Score =  113 bits (281), Expect = 3e-24
 Identities = 72/211 (34%), Positives = 113/211 (53%), Gaps = 14/211 (6%)

Query: 6   WVEKYRPRRLSEIINQEDAISKVKAWIEAWLHGNPPKKKALLLAGPPGSGKTTTVYALAR 65
           WVEKYRPR L E++ Q++ I ++K ++E     N P    LL +GPPG+GKT T  ALAR
Sbjct: 7   WVEKYRPRTLDEVVGQDEVIQRLKGYVE---RKNIPH---LLFSGPPGTGKTATAIALAR 60

Query: 66  E-----YNFEVIELNASDERTYDKIARYV-QAAYTMDILGKRRKIIFLDEADNIEPSGAP 119
           +     +    IE+NASDER  D +   + + A T  I G   KIIFLDEAD +      
Sbjct: 61  DLFGENWRDNFIEMNASDERGIDVVRHKIKEFARTAPIGGAPFKIIFLDEADALTADAQA 120

Query: 120 EIAKLIDRARNP--IIMAANHYWEVPKEIRDRAELVEYKRLTQRDVINALVRILKREGIT 177
            + + ++        I++ N+   + + I+ R  +  +K + +  +   L+ I ++EG+ 
Sbjct: 121 ALRRTMEMYSKSCRFILSCNYVSRIIEPIQSRCAVFRFKPVPKEAMKKRLLEICEKEGVK 180

Query: 178 VPKEVLVEIAKRASGDLRAAINDLQTVVAGG 208
           + ++ L  +   + GD R AIN LQ   A G
Sbjct: 181 ITEDGLEALIYISGGDFRKAINALQGAAAIG 211


>pir||C72633 probable replication factor C subunit APE1522 - Aeropyrum pernix
           (strain K1) >gi|5105207|dbj|BAA80521.1| (AP000061) 346aa
           long hypothetical replication factor C subunit
           [Aeropyrum pernix]
           Length = 346
           
 Score =  112 bits (278), Expect = 8e-24
 Identities = 92/288 (31%), Positives = 146/288 (49%), Gaps = 26/288 (9%)

Query: 3   EVPWVEKYRPRRLSEIINQEDAISKVKAWIEAWLHGNPPKKKALLLAGPPGSGKTTTVYA 62
           E+ WVEKYRPR L +I++Q+  + ++K +++     N P    LL AGPPG+GKTT  +A
Sbjct: 27  EMLWVEKYRPRSLDDIVDQKHVVERLKQFVK---QRNMPH---LLFAGPPGTGKTTAAHA 80

Query: 63  LARE-----YNFEVIELNASDERTY----DKIARYVQAAYTMDILGKRRKIIFLDEADNI 113
           LA +     Y   ++ELNASDER      +K+  + ++    +I     KI+ LDEADN+
Sbjct: 81  LAHDLFGENYRQYMLELNASDERGINVIREKVKEFARSRTPPEI---PFKIVLLDEADNM 137

Query: 114 EPSGAPEIAKLID--RARNPIIMAANHYWEVPKEIRDRAELVEYKRLTQRDVINALVRIL 171
                  + +L++   +    I+ AN+  ++   I+ R     ++ L+++DVI  L  I 
Sbjct: 138 TSDAQQALRRLMELYSSVTRFILIANYPSKIIDPIQSRCAFFRFQPLSKQDVIERLRYIA 197

Query: 172 KREGITVPKEVLVEIAKRASGDLRAAINDLQTVVAGG--YEDARYVLAYRDVEKTVFQAL 229
           + EG+   +E L  I + + GD+R AIN LQ     G    DA Y +      + V + L
Sbjct: 198 ENEGVDYEEEALDAIYEISEGDMRKAINVLQAASYLGKVTVDAVYRVVGMAKPREVREML 257

Query: 230 GLVFASD-NAKRAKL--AMMNLDMSPDEFLLWIDENIPHMYLK-PEEM 273
                 D  A R+ L   M+   MS ++    I   +    LK PEE+
Sbjct: 258 ATALKGDFTAARSLLRKIMIEYGMSGEDVARQIHRELFSTELKMPEEL 305


>gb|AAK41065.1| Activator 1, replication factor C, small subunit (rfc) [Sulfolobus
           solfataricus]
           Length = 330
           
 Score =  112 bits (277), Expect = 1e-23
 Identities = 81/251 (32%), Positives = 122/251 (48%), Gaps = 24/251 (9%)

Query: 3   EVPWVEKYRPRRLSEIINQEDAISKVKAWIEAWLHGNPPKKKALLLAGPPGSGKTTTVYA 62
           E+ W EKYRP+ L +I+NQ + I ++K +++     N P    LL AGPPG+GKTT   A
Sbjct: 7   EILWAEKYRPKTLDDIVNQREIIDRLKKFVK---EKNMPH---LLFAGPPGTGKTTAALA 60

Query: 63  LARE-----YNFEVIELNASDERTYDKIARYVQAAYTMDILGKRR-KIIFLDEADNIEPS 116
           L  +     Y    +ELNASDER  D I   V+      I G    K++ LDEADN+   
Sbjct: 61  LVHDLYGDNYTEYFLELNASDERGIDVIRNKVKEFARTVIPGDIPFKVVLLDEADNMTAD 120

Query: 117 GAPEIAKLID--RARNPIIMAANHYWEVPKEIRDRAELVEYKRLTQRDVINALVRILKRE 174
               + + ++        I+A N+  ++ + I+ R  L  +  L + DV+N L+ I K E
Sbjct: 121 AQQALRRTMELYTENTRFILACNYLSKIIEPIQSRTALFRFYPLKKEDVVNRLIYIAKNE 180

Query: 175 GITVPKEVLVEIAKRASGDLRAAINDLQTVVAGGYEDARYVLAYRDVEKTVFQALGLVFA 234
                ++ L  I     GD+R +IN LQ   A G          +   + VF+ LGL   
Sbjct: 181 KAEYDQKALETIYDITMGDMRKSINILQAASAYG----------KISVEAVFKVLGLAQP 230

Query: 235 SDNAKRAKLAM 245
            +  +   LA+
Sbjct: 231 KEVREMINLAL 241


>sp|P53034|AC14_DROME ACTIVATOR 1 40 KDA SUBUNIT (REPLICATION FACTOR C 40 KDA SUBUNIT)
           (A1 40 KDA SUBUNIT) (RF-C 40 KDA SUBUNIT) (RFC40)
           >gi|2133712|pir||S55020 replication factor C 40K chain
           homolog - fruit fly  (Drosophila melanogaster)
           >gi|639708|gb|AAB60241.1| (U15967) rfc40 [Drosophila
           melanogaster] >gi|7292439|gb|AAF47843.1| (AE003480)
           RfC40 gene product [Drosophila melanogaster]
           Length = 331
           
 Score =  112 bits (277), Expect = 1e-23
 Identities = 68/215 (31%), Positives = 113/215 (51%), Gaps = 19/215 (8%)

Query: 4   VPWVEKYRPRRLSEIINQEDAISKVKAWIEAWLHGNPPKKKALLLAGPPGSGKTTTVYAL 63
           +PW+EKYRP +  EI+  ED ++++  +      GN P    +++AGPPG GKTTT+  L
Sbjct: 16  LPWIEKYRPVKFKEIVGNEDTVARLSVFAT---QGNAPN---IIIAGPPGVGKTTTIQCL 69

Query: 64  AR-----EYNFEVIELNASDERTYD----KIARYVQAAYTMDILGKRRKIIFLDEADNIE 114
           AR      Y   V+ELNAS+ER  D    KI  + Q   T+     R KI+ LDEAD++ 
Sbjct: 70  ARILLGDSYKEAVLELNASNERGIDVVRNKIKMFAQQKVTLP--RGRHKIVILDEADSMT 127

Query: 115 PSGAPEIAKLID--RARNPIIMAANHYWEVPKEIRDRAELVEYKRLTQRDVINALVRILK 172
                 + + ++   +     +A N   ++ + I+ R  ++ + +L+   V+  L+ + K
Sbjct: 128 EGAQQALRRTMEIYSSTTRFALACNTSEKIIEPIQSRCAMLRFTKLSDAQVLAKLIEVAK 187

Query: 173 REGITVPKEVLVEIAKRASGDLRAAINDLQTVVAG 207
            E +   ++ L  I   A GD+R  +N+LQ+   G
Sbjct: 188 WEKLNYTEDGLEAIVFTAQGDMRQGLNNLQSTAQG 222


>emb|CAB57535.1| (Y18930) activator 1, replication factor C, small subunit
           [Sulfolobus solfataricus]
           Length = 330
           
 Score =  112 bits (277), Expect = 1e-23
 Identities = 81/251 (32%), Positives = 122/251 (48%), Gaps = 24/251 (9%)

Query: 3   EVPWVEKYRPRRLSEIINQEDAISKVKAWIEAWLHGNPPKKKALLLAGPPGSGKTTTVYA 62
           E+ W EKYRP+ L +I+NQ + I ++K +++     N P    LL AGPPG+GKTT   A
Sbjct: 7   EILWAEKYRPKTLDDIVNQREIIDRLKKFVK---EKNMPH---LLFAGPPGTGKTTAALA 60

Query: 63  LARE-----YNFEVIELNASDERTYDKIARYVQAAYTMDILGKRR-KIIFLDEADNIEPS 116
           L  +     Y    +ELNASDER  D I   V+      I G    K++ LDEADN+   
Sbjct: 61  LVHDLYGDNYTEYFLELNASDERGIDVIRNKVKEFARTVIPGDIPFKVVLLDEADNMTAD 120

Query: 117 GAPEIAKLID--RARNPIIMAANHYWEVPKEIRDRAELVEYKRLTQRDVINALVRILKRE 174
               + + ++        I+A N+  ++ + I+ R  L  +  L + DV+N L+ I K E
Sbjct: 121 AQQALRRTMELYTENTRFILACNYLSKIIEPIQSRTALFRFYPLKKEDVVNRLIYIAKNE 180

Query: 175 GITVPKEVLVEIAKRASGDLRAAINDLQTVVAGGYEDARYVLAYRDVEKTVFQALGLVFA 234
                ++ L  I     GD+R +IN LQ   A G          +   + VF+ LGL   
Sbjct: 181 KAEYDQKALETIYDITMGDMRKSINILQAASAYG----------KISVEAVFKVLGLAQP 230

Query: 235 SDNAKRAKLAM 245
            +  +   LA+
Sbjct: 231 KEVREMINLAL 241


>emb|CAA07618.1| (AJ007712) replication factor C subunit [Arxula adeninivorans]
           Length = 338
           
 Score =  109 bits (269), Expect = 9e-23
 Identities = 67/211 (31%), Positives = 110/211 (51%), Gaps = 14/211 (6%)

Query: 4   VPWVEKYRPRRLSEIINQEDAISKVKAWIEAWLHGNPPKKKALLLAGPPGSGKTTTVYAL 63
           +PWVEKYRP  L E+   E  I+ +K ++E    G  P    LL  GPPG+GKTTT+ A+
Sbjct: 17  LPWVEKYRPTTLDEVAGHEGVITTIKKFVE---EGKLPH---LLFHGPPGTGKTTTIIAV 70

Query: 64  ARE-----YNFEVIELNASDERTYDKIARYVQA-AYTMDILGKRRKIIFLDEADNIEPSG 117
           AR+     Y   ++ELNASDER  D +   ++  A T  I     K++ LDEAD +  + 
Sbjct: 71  ARQIYGKNYRNMILELNASDERGIDVVRDQIKTFASTRQIFSSGFKLVILDEADAMTNAA 130

Query: 118 APEIAKLIDR--ARNPIIMAANHYWEVPKEIRDRAELVEYKRLTQRDVINALVRILKREG 175
              + ++I++  A     + AN+  ++   +  R     +  L +  + + L  ++++E 
Sbjct: 131 QNALRRIIEKYSAHTRFCILANYTHKLNPALLSRCTRFRFSPLKEDAIKHRLAHVIEQES 190

Query: 176 ITVPKEVLVEIAKRASGDLRAAINDLQTVVA 206
           + +  E    +   +SGD+R A+N LQ   A
Sbjct: 191 VDLSPEAFQSLLHLSSGDMRRALNVLQACYA 221


>gb|AAB88360.1| (AF036699) strong similarity to the activator 1 36 to 40 KD
           subunits family of DNA replication factors
           [Caenorhabditis elegans]
           Length = 334
           
 Score =  108 bits (267), Expect = 1e-22
 Identities = 72/210 (34%), Positives = 113/210 (53%), Gaps = 15/210 (7%)

Query: 5   PWVEKYRPRRLSEIINQEDAISKVKAWIEAWLHGNPPKKKALLLAGPPGSGKTTTVYALA 64
           PWVEKYRP+ L++I+  E+ + ++K        GN P    ++L+GPPG GKTT+V+ALA
Sbjct: 11  PWVEKYRPKVLADIVGNENIVERLKV---IGHEGNVPN---IVLSGPPGCGKTTSVWALA 64

Query: 65  REYNFE-----VIELNASDERTYDKIARYVQA-AYTMDILGK-RRKIIFLDEADNIEPSG 117
           RE   +     V+ELNASDER  D +   ++  A T   L + R KII LDEAD++    
Sbjct: 65  RELLGDKVKEAVLELNASDERGIDVVRHRIKTFAQTKVTLPEGRHKIIILDEADSMTDGA 124

Query: 118 APEIAKLIDRARNP--IIMAANHYWEVPKEIRDRAELVEYKRLTQRDVINALVRILKREG 175
              + + ++         +A N   ++ + I+ R  L+ Y +L+   ++  +  + K E 
Sbjct: 125 QQALRRTMEMYTKTTRFALACNQSEKIIEPIQSRCALLRYTKLSPVQLLTRVKEVAKAEK 184

Query: 176 ITVPKEVLVEIAKRASGDLRAAINDLQTVV 205
           +      L  I   A GD+R A+N+LQ  V
Sbjct: 185 VNYDDGGLEAILFTAQGDMRQALNNLQATV 214


>pir||B69130 replication factor C, small subunit - Methanobacterium
           thermoautotrophicum (strain Delta H)
           >gi|2621290|gb|AAB84747.1| (AE000811) replication factor
           C, small subunit  [Methanobacterium thermoautotrophicum]
           Length = 321
           
 Score =  106 bits (262), Expect = 6e-22
 Identities = 85/308 (27%), Positives = 137/308 (43%), Gaps = 34/308 (11%)

Query: 5   PWVEKYRPRRLSEIINQEDAISKVKAWIEAWLHGNPPKKKALLLAGPPGSGKTTTVYALA 64
           PWVEKYRP++L +I+ QE  I ++K ++E     N      L+  GP G GKTT   ALA
Sbjct: 7   PWVEKYRPQKLDDIVGQEHIIPRLKRYVEEKSMPN------LMFTGPAGVGKTTAALALA 60

Query: 65  RE-----YNFEVIELNASDERTYDKIARYVQAAYTMDILGKRRKIIFLDEADNIEPSGAP 119
           RE     +    +ELNASD R  D +   ++    +  +G   +IIFLDE DN+      
Sbjct: 61  REILGEYWRQNFLELNASDARGIDTVRTSIKNFCRLKPVGAPFRIIFLDEVDNMTKDAQH 120

Query: 120 EIAKLID--RARNPIIMAANHYWEVPKEIRDRAELVEYKRLTQRDVINALVRILKREGIT 177
            + + ++     +  I++ N+  ++   I+ R  +  +  L    +I  L  I ++E + 
Sbjct: 121 ALRREMEMYTKTSSFILSCNYSSKIIDPIQSRCAIFRFLPLKGHQIIKRLEYIAEKENLE 180

Query: 178 VPKEVLVEIAKRASGDLRAAINDLQTVVAGGYEDARYVLAYRDVEKTVFQALGLVFASDN 237
                L  I   A GDLR AIN LQ+  +         L  +  E +++  +      D 
Sbjct: 181 YEAHALETIVYFAEGDLRKAINLLQSAAS---------LGEKITESSIYDVVSRARPKDV 231

Query: 238 AKRAKLAMMNLDMSPDEFLLWI--------DENIPHMYLKPEEMAR-AYEAISKADIYLG 288
            K  K  +    M   + L  I        ++ +  +Y   +E++R A E     D Y+G
Sbjct: 232 RKMIKTILDGKFMEARDMLREIMVLQGISGEDMVTQIY---QELSRLAMEGEVDGDRYVG 288

Query: 289 RAQRTGNY 296
                G Y
Sbjct: 289 LIDAIGEY 296


>gi|6324039 Subunit 3 of Replication Factor C; homologous to human RFC 36 kDa
           subunit; Rfc3p [Saccharomyces cerevisiae]
           >gi|585844|sp|P38629|RFC3_YEAST ACTIVATOR 1 40 KD
           SUBUNIT (REPLICATION FACTOR C 40 KD SUBUNIT)
           >gi|1078326|pir||A36988 replication factor C chain RFC3
           [validated] - yeast  (Saccharomyces cerevisiae)
           >gi|439118|gb|AAA34969.1| (L18755) replication factor C
           [Saccharomyces cerevisiae] >gi|841466|gb|AAC49062.1|
           (U26029) Rfc3p [Saccharomyces cerevisiae]
           >gi|1050872|gb|AAC49110.1| (U23084) replication factor
           C, 40 kDa subunit [Saccharomyces cerevisiae]
           >gi|1302375|emb|CAA96207.1| (Z71566) ORF YNL290w
           [Saccharomyces cerevisiae]
           Length = 340
           
 Score =  104 bits (257), Expect = 2e-21
 Identities = 67/211 (31%), Positives = 110/211 (51%), Gaps = 14/211 (6%)

Query: 4   VPWVEKYRPRRLSEIINQEDAISKVKAWIEAWLHGNPPKKKALLLAGPPGSGKTTTVYAL 63
           +PWVEKYRP  L E+  Q + I+ V+ +++    G  P    LL  GPPG+GKT+T+ AL
Sbjct: 13  LPWVEKYRPETLDEVYGQNEVITTVRKFVD---EGKLPH---LLFYGPPGTGKTSTIVAL 66

Query: 64  ARE-----YNFEVIELNASDERTYDKIARYVQ-AAYTMDILGKRRKIIFLDEADNIEPSG 117
           ARE     Y+  V+ELNASD+R  D +   ++  A T  I  K  K+I LDEAD +  + 
Sbjct: 67  AREIYGKNYSNMVLELNASDDRGIDVVRNQIKDFASTRQIFSKGFKLIILDEADAMTNAA 126

Query: 118 APEIAKLIDR--ARNPIIMAANHYWEVPKEIRDRAELVEYKRLTQRDVINALVRILKREG 175
              + ++I+R        + AN+  ++   +  R     ++ L Q  +   +  +L  E 
Sbjct: 127 QNALRRVIERYTKNTRFCVLANYAHKLTPALLSRCTRFRFQPLPQEAIERRIANVLVHEK 186

Query: 176 ITVPKEVLVEIAKRASGDLRAAINDLQTVVA 206
           + +       + + ++GD+R  +N LQ+  A
Sbjct: 187 LKLSPNAEKALIELSNGDMRRVLNVLQSCKA 217


>gi|6677723 replication factor C (activator 1) 5 (36.5kD) [Homo sapiens]
           >gi|728777|sp|P40937|AC11_HUMAN ACTIVATOR 1 36 KDA
           SUBUNIT (REPLICATION FACTOR C 36 KDA SUBUNIT) (A1 36 KDA
           SUBUNIT) (RF-C 36 KDA SUBUNIT) (RFC36)
           >gi|1498257|gb|AAB09784.1| (L07540) replication factor
           C, 36-kDa subunit [Homo sapiens]
           Length = 340
           
 Score =  103 bits (255), Expect = 4e-21
 Identities = 73/245 (29%), Positives = 126/245 (50%), Gaps = 26/245 (10%)

Query: 4   VPWVEKYRPRRLSEIINQEDAISKVKAWIEAWLHGNPPKKKALLLAGPPGSGKTTTVYAL 63
           +PWVEKYRP+ L+++I+ +D +S ++ +I      N  +   LLL GPPG+GKT+T+ A 
Sbjct: 20  LPWVEKYRPQTLNDLISHQDILSTIQKFI------NEDRLPHLLLYGPPGTGKTSTILAC 73

Query: 64  A------REYNFEVIELNASDERTYDKI-ARYVQAAYTMDILGKRRKIIFLDEADNIEPS 116
           A      +E+   V+ELNASD+R  D I    +  A T  I  K  K++ LDEAD +   
Sbjct: 74  AKQLYKDKEFGSMVLELNASDDRGIDIIRGPILSFASTRTIFKKGFKLVILDEADAMTQD 133

Query: 117 GAPEIAKLIDR--ARNPIIMAANHYWEVPKEIRDRAELVEYKRLTQRDVINALVRILKRE 174
               + ++I++        +  N+  ++   ++ R     +  LT   ++  L  +++ E
Sbjct: 134 AQNALRRVIEKFTENTRFCLICNYLSKIIPALQSRCTRFRFGPLTPELMVPRLEHVVEEE 193

Query: 175 GITVPKEVLVEIAKRASGDLRAAINDLQ-TVVAGGYEDARYVLAYRDVEKTVFQALGLVF 233
            + + ++ +  +   +SGD+R A+N LQ T +A G          +  E+TV+   G   
Sbjct: 194 KVDISEDGMKALVTLSSGDMRRALNILQSTNMAFG----------KVTEETVYTCTGHPL 243

Query: 234 ASDNA 238
            SD A
Sbjct: 244 KSDIA 248


>gi|4506491 replication factor C (activator 1) 4 (37kD) [Homo sapiens]
           >gi|11435044|ref|XP_003190.1| replication factor C
           (activator 1) 4 (37kD) [Homo sapiens]
           >gi|1703052|sp|P35249|AC12_HUMAN ACTIVATOR 1 37 KD
           SUBUNIT (REPLICATION FACTOR C 37 KD SUBUNIT) (A1 37 KD
           SUBUNIT) (RF-C 37 KD SUBUNIT) (RFC37)
           >gi|1498256|gb|AAB09785.1| (M87339) replication factor
           C, 37-kDa subunit [Homo sapiens]
           Length = 363
           
 Score =  103 bits (255), Expect = 4e-21
 Identities = 71/231 (30%), Positives = 114/231 (48%), Gaps = 24/231 (10%)

Query: 4   VPWVEKYRPRRLSEIINQEDAISKVKAWIEAWLHGNPPKKKALLLAGPPGSGKTTTVYAL 63
           VPWVEKYRP+ + E+  QE+ ++ +K  +E     N      LL  GPPG+GKT+T+ A 
Sbjct: 38  VPWVEKYRPKCVDEVAFQEEVVAVLKKSLEGADLPN------LLFYGPPGTGKTSTILAA 91

Query: 64  ARE------YNFEVIELNASDERTYDKIARYVQAAYTMDILGKRR--------KIIFLDE 109
           ARE      +   V+ELNASDER    +   V+    + + G R         KI+ LDE
Sbjct: 92  ARELFGPELFRLRVLELNASDERGIQVVREKVKNFAQLTVSGSRSDGKPCPPFKIVILDE 151

Query: 110 ADNIEPSGAPEIAKLIDRARNP--IIMAANHYWEVPKEIRDRAELVEYKRLTQRDVINAL 167
           AD++  +    + + +++        +  N+   + + +  R     +K L+ +     L
Sbjct: 152 ADSMTSAAQAALRRTMEKESKTTRFCLICNYVSRIIEPLTSRCSKFRFKPLSDKIQQQRL 211

Query: 168 VRILKREGITVPKEVLVEIAKRASGDLRAAINDLQ--TVVAGGYEDARYVL 216
           + I K+E + +  E +  + K + GDLR AI  LQ  T + GG E    V+
Sbjct: 212 LDIAKKENVKISDEGIAYLVKVSEGDLRKAITFLQSATRLTGGKEITEKVI 262


>pir||A45253 activator 1 37K chain - human
           Length = 363
           
 Score =  102 bits (252), Expect = 8e-21
 Identities = 70/233 (30%), Positives = 114/233 (48%), Gaps = 24/233 (10%)

Query: 4   VPWVEKYRPRRLSEIINQEDAISKVKAWIEAWLHGNPPKKKALLLAGPPGSGKTTTVYAL 63
           VPWVEKYRP+ + E+  QE+ ++ +K  +E     N      LL  GPPG+GKT+T+ A 
Sbjct: 38  VPWVEKYRPKCVDEVAFQEEVVAVLKKSLEGADLPN------LLFYGPPGTGKTSTILAA 91

Query: 64  ARE------YNFEVIELNASDERTYDKIARYVQAAYTMDILGKRR--------KIIFLDE 109
           ARE      +   V+ELNASDER    +   V+    + + G R         KI+ LDE
Sbjct: 92  ARELFGPELFRLRVLELNASDERGIQVVREKVKNFAQLTVSGSRSDGKPCPPFKIVILDE 151

Query: 110 ADNIEPSGAPEIAKLIDRARNP--IIMAANHYWEVPKEIRDRAELVEYKRLTQRDVINAL 167
           AD++  +    + + +++        +  N+   + + +  R     +K L+ +     L
Sbjct: 152 ADSMTSAAQAALRRTMEKESKTTRFCLICNYVSRIIEPLTSRCSKFRFKPLSDKIQQQRL 211

Query: 168 VRILKREGITVPKEVLVEIAKRASGDLRAAINDLQ--TVVAGGYEDARYVLAY 218
           + I K+E + +    +  + K + GDLR AI  LQ  T + GG E    V+ +
Sbjct: 212 LDIAKKENVPISHRGIAYLVKVSEGDLRKAITFLQSATRLTGGKEITEKVITH 264


>gb|AAG20394.1| (AE005112) replication factor C small subunit; RfcA [Halobacterium
           sp. NRC-1]
           Length = 322
           
 Score = 99.5 bits (244), Expect = 7e-20
 Identities = 75/293 (25%), Positives = 137/293 (46%), Gaps = 21/293 (7%)

Query: 6   WVEKYRPRRLSEIINQEDAISKVKAWIEAWLHGNPPKKKALLLAGPPGSGKTTTVYALAR 65
           WVEKYRP RL +++   D   +++++++            LL AGP G+GKT +  ++A+
Sbjct: 12  WVEKYRPERLEDVVGHPDITERLQSYVDR------DDLPHLLFAGPAGTGKTASSVSIAK 65

Query: 66  E-----YNFEVIELNASDERTYDKIARYVQAAYTMDILGKRRKIIFLDEADNIEPSGAPE 120
           E     +    +ELNASDER  D +   ++        G   ++IFLDEAD +       
Sbjct: 66  ELYGDDWQDNFLELNASDERGIDVVRDRIKDFARSSFGGHNYRVIFLDEADALTDDAQSA 125

Query: 121 IAKLIDRARN--PIIMAANHYWEVPKEIRDRAELVEYKRLTQRDVINALVRILKREGITV 178
           + + +++  N    I++ N+  ++   I+ R  +  + +L    V   L  I + EG+  
Sbjct: 126 LRRTMEQFSNNTRFILSCNYSSKIIDPIQSRCAVFRFAQLGDDAVAAHLREIAETEGLEH 185

Query: 179 PKEVLVEIAKRASGDLRAAINDLQTVVAGG---YEDARYVLAY----RDVEKTVFQALGL 231
             + +  +   A GD+R AIN LQ   A G    E+  Y +       ++E  V +ALG 
Sbjct: 186 TDDGIDALVYAADGDMRRAINALQAASATGDSVNEETVYAITATARPEEIETMVTEALGG 245

Query: 232 VFASDNAKRAKLAMMNLDMSPDEFLLWIDENIPHMYLKPEEMARAYEAISKAD 284
            FA+  A    L + N  ++  + +  +  ++    ++     R  + + +AD
Sbjct: 246 DFAAARATLDDL-LTNRGLAGGDIIDQVHRSVWEFDVEEAAAVRLLDRLGEAD 297


>pir||D71603 replication factor C, 140 kDa subunit (ATPase) PFB0895c - malaria
           parasite (Plasmodium falciparum)
           >gi|3845304|gb|AAC71968.1| (AE001423) replication factor
           C, 140 kDa subunit (ATPase) [Plasmodium falciparum]
           Length = 904
           
 Score = 99.1 bits (243), Expect = 1e-19
 Identities = 66/224 (29%), Positives = 110/224 (48%), Gaps = 27/224 (12%)

Query: 6   WVEKYRPRRLSEIINQEDAISKVKAWIEAW----LHG--NPPKK-----------KALLL 48
           WVEKYRP+ L+E++     + K++ W+ +W    + G   P +K           +  LL
Sbjct: 353 WVEKYRPKNLNELVGNNQNVIKLQNWLASWEDVCIKGIKKPAQKTFRGIFENVNARCALL 412

Query: 49  AGPPGSGKTTTVYALAREYNFEVIELNASDER---TYDKIARYVQAAYTMDILGKR---R 102
           +GP G GKTTT   ++    + VIE NASDER     +KI+      Y++  L  R   +
Sbjct: 413 SGPAGIGKTTTAKIVSEASGYNVIEFNASDERNKAAVEKISEMATGGYSIMSLNNRKLTK 472

Query: 103 KIIFLDEADNI---EPSGAPEIAKLIDRARNPIIMAAN-HYWEVPKEIRDRAELVEYKRL 158
             I +DE D +   +  G+  I KLI++ + PII   N       + + ++   +++   
Sbjct: 473 TCIIMDEVDGMSSGDKGGSTAILKLIEKTKCPIICICNDRQNNKMRTLANKCYDLKFSMP 532

Query: 159 TQRDVINALVRILKREGITVPKEVLVEIAKRASGDLRAAINDLQ 202
            +  V+  L+ I K+EGI +    L  + +   GD+R  +N LQ
Sbjct: 533 QKNSVVKRLLEICKKEGIMMEPNALELLWESTCGDIRQMLNTLQ 576


>pir||T43410 replication factor C chain Rfc3 - fission yeast
           (Schizosaccharomyces pombe) >gi|4468733|emb|CAB38106.1|
           (AJ012839) replication factor C subunit
           [Schizosaccharomyces pombe] >gi|5688939|dbj|BAA82745.1|
           (AB017039) Rfc3 [Schizosaccharomyces pombe]
           >gi|5688941|dbj|BAA82746.1| (AB017040) Rfc3
           [Schizosaccharomyces pombe]
           Length = 342
           
 Score = 99.1 bits (243), Expect = 1e-19
 Identities = 57/207 (27%), Positives = 111/207 (53%), Gaps = 14/207 (6%)

Query: 4   VPWVEKYRPRRLSEIINQEDAISKVKAWIEAWLHGNPPKKKALLLAGPPGSGKTTTVYAL 63
           +PWVEKYRP  L ++++ +D IS ++ +I +       +   +L  GPPG+GKT+T+ A 
Sbjct: 23  LPWVEKYRPANLEDVVSHKDIISTLEKFISS------NRVPHMLFYGPPGTGKTSTILAC 76

Query: 64  ARE-----YNFEVIELNASDERTYDKIARYVQ-AAYTMDILGKRRKIIFLDEADNIEPSG 117
           AR+     Y  +++ELNASD+R  D +   ++  A T  I     K+I LDEAD +  + 
Sbjct: 77  ARKIYGPNYRNQLMELNASDDRGIDAVREQIKNFASTRQIFASTFKMIILDEADAMTLAA 136

Query: 118 APEIAKLIDRARNPI--IMAANHYWEVPKEIRDRAELVEYKRLTQRDVINALVRILKREG 175
              + ++I++    +   +  N+  ++   I+ R     ++ L  +++   +  +++ E 
Sbjct: 137 QNALRRVIEKYTKNVRFCIICNYINKISPAIQSRCTRFRFQPLPPKEIEKTVDHVIQSEH 196

Query: 176 ITVPKEVLVEIAKRASGDLRAAINDLQ 202
             +  +  + + + + GD+R A+N LQ
Sbjct: 197 CNIDPDAKMAVLRLSKGDMRKALNILQ 223


>emb|CAC12618.1| (AL445067) probable replication factor C, 40 KD subunit
           [Thermoplasma acidophilum]
           Length = 330
           
 Score = 97.5 bits (239), Expect = 3e-19
 Identities = 85/331 (25%), Positives = 157/331 (46%), Gaps = 39/331 (11%)

Query: 6   WVEKYRPRRLSEIINQEDAISKVKAWIEAWLHGNPPKKKA--LLLAGPPGSGKTTTVYAL 63
           W EKYRP+ LSEI  +++ I K+K+++E        KK+   LL AG  G+GKT+T  AL
Sbjct: 17  WTEKYRPKSLSEIYGEDENIQKLKSFVE--------KKEIPHLLFAGSVGTGKTSTAIAL 68

Query: 64  ARE-----YNFEVIELNASDERTYDKIARYVQAAYTM---DILGKRRKIIFLDEADNIEP 115
           A E     +   ++E+NAS+E   D I   ++    +   + LG   KI+FLDEAD +  
Sbjct: 69  AIELFGDSWKENMVEMNASNENGIDVIRNKIKDIARIKPSNPLGF--KILFLDEADQLTA 126

Query: 116 SGAPEIAKLID--RARNPIIMAANHYWEVPKEIRDRAELVEYKRLTQRDVINALVRILKR 173
                + + ++        I + N+  ++   I+ R  ++ ++ +    +   L  I K 
Sbjct: 127 EAQAALRRTMEIYSETTRFIFSCNYSSKIIPPIQSRTVVMRFRPVPDEYISRKLQEIAKN 186

Query: 174 EGITVPKEVLVEIAKRASGDLRAAINDLQTVVAGG-------YEDARYVLAYRDVEKTVF 226
           EG  + +E +  + + ++GD+R AIN LQ V   G       YE   Y  +   ++K + 
Sbjct: 187 EGFQIDEESMHALVEVSAGDMRKAINVLQAVYTSGEISPKKIYEIIGYA-SPEKIQKMIS 245

Query: 227 QALGLVFASDNAKRAKLAMMNLD-MSPDEFLLWIDENIPHMYLKPEEMARAYEAISKADI 285
           +A+  +F  D A+     M+  D +S  + +  +   +    + P++     +A++ A+ 
Sbjct: 246 RAINGLF--DEAREIVDGMLIYDGLSGIDIVRSLHSYVRSSMISPKQKIEIIKALADAEF 303

Query: 286 YLGRAQRTGNYSLWRYAIDMMTAGVAVAGTK 316
            +            R  +D + A +A  G++
Sbjct: 304 RIVEGSND------RIQLDALIAKLAEIGSR 328


>dbj|BAB16439.1| (AB038319) replication factor C 36kDa subunit [Oryza sativa]
           Length = 367
           
 Score = 96.3 bits (236), Expect = 6e-19
 Identities = 63/210 (30%), Positives = 107/210 (50%), Gaps = 17/210 (8%)

Query: 5   PWVEKYRPRRLSEIINQEDAISKVKAWIEAWLHGNPPKKKALLLAGPPGSGKTTTVYALA 64
           PWVEKYRP+ L ++    D +  +          N  +   LLL GPPG+GKT+T+ A+A
Sbjct: 39  PWVEKYRPQSLGDVAAHRDIVDTIDRLT------NENRLPHLLLYGPPGTGKTSTILAVA 92

Query: 65  R-----EYNFEVIELNASDERTYDKIARYVQ---AAYTMDILGKRR-KIIFLDEADNIEP 115
           R     +Y   ++ELNASDER  D + + +Q   +A ++    K+  K++ LDEAD +  
Sbjct: 93  RKLYGSQYGNMILELNASDERGIDVVRQQIQDFASARSLSFGAKQSVKMVLLDEADAMTK 152

Query: 116 SGAPEIAKLIDR--ARNPIIMAANHYWEVPKEIRDRAELVEYKRLTQRDVINALVRILKR 173
                + ++I++        +  NH  ++   ++ R     +  L    V   L  I++ 
Sbjct: 153 DAQFALRRVIEKHTRSTRFALICNHVNKIIPALQSRCTRFRFAPLDGTHVRERLKHIIQS 212

Query: 174 EGITVPKEVLVEIAKRASGDLRAAINDLQT 203
           EG+ V    L  + + ++GD+R A+N LQ+
Sbjct: 213 EGLDVDDGGLTALVRLSNGDMRKALNILQS 242


>pir||H71604 replication factor C, 40 kDa subunit (replication activator)
           PFB0840w - malaria parasite (Plasmodium falciparum)
           >gi|3845290|gb|AAC71957.1| (AE001420) replication factor
           C, 40 kDa subunit (replication activator) [Plasmodium
           falciparum]
           Length = 330
           
 Score = 96.0 bits (235), Expect = 8e-19
 Identities = 66/222 (29%), Positives = 110/222 (48%), Gaps = 27/222 (12%)

Query: 1   MPEVPWVEKYRPRRLSEIINQEDAISKVKAWIEAWLHGNPPKKKALLLAGPPGSGKTTTV 60
           M  +PWVEKYRP+RL +I++Q +A+  +K  +      N P    L+  GPPG+GKT+ +
Sbjct: 1   MENIPWVEKYRPKRLDDIVHQNNAVMMLKEVVRT---KNMPH---LIFHGPPGTGKTSAI 54

Query: 61  YALARE------YNFEVIELNASDERTYDKIARYVQAAYTMDILGKRR------------ 102
            ALA E       +  V+ELNASD+R  + +   ++ AYT   + K +            
Sbjct: 55  NALAHELFGKENISERVLELNASDDRGINVVREKIK-AYTRISISKNKIHSETKEVLPSW 113

Query: 103 KIIFLDEADNIEPSGAPEIAKLIDRARN--PIIMAANHYWEVPKEIRDRAELVEYKRLTQ 160
           K++ LDEAD +       + ++I+   N    I+  N+  ++   I  R     ++ +  
Sbjct: 114 KLVVLDEADMMTEDAQSALRRIIEIYSNVTRFILICNYIHKISDPIFSRCSCYRFQSIPI 173

Query: 161 RDVINALVRILKREGITVPKEVLVEIAKRASGDLRAAINDLQ 202
                 L+ I + E I +  + L +I +   GDLR A++ LQ
Sbjct: 174 NIKKEKLLYICQNENIDIVDDALEKIIETTEGDLRRAVSILQ 215


>gb|AAG37987.1|AF071409_1 (AF071409) replication factor C subunit 2; RFC2 [Plasmodium
           falciparum]
           Length = 330
           
 Score = 96.0 bits (235), Expect = 8e-19
 Identities = 66/222 (29%), Positives = 110/222 (48%), Gaps = 27/222 (12%)

Query: 1   MPEVPWVEKYRPRRLSEIINQEDAISKVKAWIEAWLHGNPPKKKALLLAGPPGSGKTTTV 60
           M  +PWVEKYRP+RL +I++Q +A+  +K  +      N P    L+  GPPG+GKT+ +
Sbjct: 1   MENIPWVEKYRPKRLDDIVHQNNAVMMLKEVVRT---KNMPH---LIFHGPPGTGKTSAI 54

Query: 61  YALARE------YNFEVIELNASDERTYDKIARYVQAAYTMDILGKRR------------ 102
            ALA E       +  V+ELNASD+R  + +   ++ AYT   + K +            
Sbjct: 55  NALAHELFGKENISERVLELNASDDRGINVVREKIK-AYTRISISKNKIHSETKEVLPSW 113

Query: 103 KIIFLDEADNIEPSGAPEIAKLIDRARN--PIIMAANHYWEVPKEIRDRAELVEYKRLTQ 160
           K++ LDEAD +       + ++I+   N    I+  N+  ++   I  R     ++ +  
Sbjct: 114 KLVVLDEADMMTEDAQSALRRIIEIYSNVTRFILICNYIHKISDPIFSRCSCYRFQSIPI 173

Query: 161 RDVINALVRILKREGITVPKEVLVEIAKRASGDLRAAINDLQ 202
                 L+ I + E I +  + L +I +   GDLR A++ LQ
Sbjct: 174 NIKKEKLLYICQNENIDIVDDALEKIIETTEGDLRRAVSILQ 215


>pir||A49393 activator 1 large chain - mouse >gi|405112|gb|AAA21643.1| (U01222)
            murine A1-p145 [Mus musculus]
            Length = 1131
            
 Score = 94.8 bits (232), Expect = 2e-18
 Identities = 132/571 (23%), Positives = 238/571 (41%), Gaps = 120/571 (21%)

Query: 6    WVEKYRPRRLSEIINQE---DAISKVKAWIEAWLHGNPPKKK------------------ 44
            WV+KY+P  L  II Q+      +K+  W+  W   +P +KK                  
Sbjct: 570  WVDKYKPASLKNIIGQQGDQSCANKLLRWLRNWHKSSPEEKKHAAKFGKLASKDDGSSFK 629

Query: 45   ALLLAGPPGSGKTTTVYALAREYNFEVIELNASDERTYDKIARYV-QAAYTMDILG---- 99
            A LL+GPPG GKTTT   + +E  +  +ELNASD R+ + +   V ++     I G    
Sbjct: 630  AALLSGPPGVGKTTTASLVCQELGYSYVELNASDTRSKNSLKAVVAESLNNTSIKGFYTS 689

Query: 100  ------KRRKIIFLDEAD----NIEPSGAPEIAKLIDRARNPIIMAANHYWEVPKEIRDR 149
                    R  + +DE D    N +  G  E+  LI   + PII   N     PK IR  
Sbjct: 690  GAAPSVSARHALIMDEVDGMAGNEDRGGIQELIGLIKHTKIPIICMCNDR-NHPK-IRSL 747

Query: 150  AEL---VEYKRLTQRDVINALVRILKREGITVPKEVLVEIAKRASGDLRAAINDLQTVVA 206
                  + ++R     + +A++ I  +EG+ +P   + EI   A+ D+R  +++L    A
Sbjct: 748  VHYCFDLRFQRPRVEQIKSAMLSIAFKEGLKIPPPAMNEIILGANQDVRQVLHNLSMWCA 807

Query: 207  GG----YEDAR--YVLAYRDVEKTVFQALGLVFASDNAKRAKLAMMNLDMSPDEFL---- 256
                  Y+ A+     A +D+    F     VFA+      + A M+L    D F     
Sbjct: 808  QSKALTYDQAKADSQRAKKDIRLGPFDVTRKVFAAGE----ETAHMSLMDKSDLFFHDYS 863

Query: 257  ---LWIDENIPHMYLKPEE-----------MARAYEAISKADIYLGRAQRTGNYSLWRYA 302
               L++ EN  ++++KP             ++RA ++I   D+   + +   N+SL    
Sbjct: 864  IAPLFVQEN--YLHVKPVAAGGDMKKHLMLLSRAADSICDGDLVDNQIRSKQNWSL--LP 919

Query: 303  IDMMTAGVAVAGTKKRGFAKFYP--PNTL-KMLAESKEER-------------------- 339
               + A V + G   RG+   +P  PN L K  +  K +R                    
Sbjct: 920  TQAIYASV-LPGELMRGYMTQFPSFPNWLGKHSSTGKHDRIVQDLSLHMSLRTYSSKRTV 978

Query: 340  ------STRNSIIKKIMSE-----MHMSKLEAIETMKIIKTIFEKNLDLAAHFTVFLGLS 388
                    R+++++ + S+      H+ KL  ++T  ++K  FE  +++++        S
Sbjct: 979  NMDYLSHIRDALVRPLTSQGVEGAQHVIKL--MDTYYLMKEDFENIMEVSSWGGKPSAFS 1036

Query: 389  EKEVEFLA------GRENAGTIWGKALAIRRKLKKEEEKIRKERKEEEKVEVREEKPEEK 442
            + + +  A       +E   T +   +    +L        +  +E ++ + + EK ++ 
Sbjct: 1037 KLDPKVKAAFTRAYNKEAHLTPYSLQVVKTSRLSTGPALDSEYSEEFQEDDTQSEKEQDA 1096

Query: 443  VEE----KREERETKKEKEKKEEKKAEKKGK 469
            VE     K++ R +K  K ++E++  + KGK
Sbjct: 1097 VETDAMIKKKTRSSKPSKSEREKESKKGKGK 1127


>gb|AAF63387.1|AF247499_1 (AF247499) replication factor C subunit 3 [Drosophila melanogaster]
           Length = 332
           
 Score = 93.6 bits (229), Expect = 4e-18
 Identities = 61/211 (28%), Positives = 110/211 (51%), Gaps = 15/211 (7%)

Query: 4   VPWVEKYRPRRLSEIINQEDAISKVKAWIEAWLHGNPPKKKALLLAGPPGSGKTTTVYAL 63
           +PWVEKYRP  L ++I+ E+ IS +  +I      +  +   LL  GPPG+GKT+T+ A 
Sbjct: 11  MPWVEKYRPSGLDDLISHEEIISTITRFI------SRKQLPHLLFYGPPGTGKTSTILAC 64

Query: 64  AR------EYNFEVIELNASDERTYDKI-ARYVQAAYTMDILGKRRKIIFLDEADNIEPS 116
           AR      ++   V+ELNASD+R    +  + +  A T  I     K+I LDEAD +   
Sbjct: 65  ARQLYSPQQFKSMVLELNASDDRGIGIVRGQILNFASTRTIFCDTFKLIILDEADAMTND 124

Query: 117 GAPEIAKLIDRARNPI--IMAANHYWEVPKEIRDRAELVEYKRLTQRDVINALVRILKRE 174
               + ++I++  + +   +  N+  ++   ++ R     +  L+Q  ++  L +I++ E
Sbjct: 125 AQNALRRIIEKYTDNVRFCVICNYLSKIIPALQSRCTRFRFAPLSQDQMMPRLEKIIEAE 184

Query: 175 GITVPKEVLVEIAKRASGDLRAAINDLQTVV 205
            + + ++    +   A GD+R  +N LQ+ V
Sbjct: 185 AVQITEDGKRALLTLAKGDMRKVLNVLQSTV 215


>pir||A56284 differentiation-specific element binding protein - mouse
            >gi|1022776|gb|AAA79698.1| (U36441) differentiation
            specific element binding protein [Mus musculus]
            Length = 1130
            
 Score = 93.2 bits (228), Expect = 6e-18
 Identities = 131/570 (22%), Positives = 238/570 (40%), Gaps = 119/570 (20%)

Query: 6    WVEKYRPRRLSEIINQE---DAISKVKAWIEAWLHGNPPKKK-----------------A 45
            WV+KY+P  L  II Q+      +K+  W+  W   +P +KK                 A
Sbjct: 570  WVDKYKPASLKNIIGQQGDQSCANKLLRWLRNWHKSSPEEKKHAKFGKLASKDDGSSFKA 629

Query: 46   LLLAGPPGSGKTTTVYALAREYNFEVIELNASDERTYDKIARYV-QAAYTMDILG----- 99
             LL+GPPG GKTTT   + +E  +  +ELNASD R+ + +   V ++     I G     
Sbjct: 630  ALLSGPPGVGKTTTASLVCQELGYSYVELNASDTRSKNSLKAVVAESLNNTSIKGFYTSG 689

Query: 100  -----KRRKIIFLDEAD----NIEPSGAPEIAKLIDRARNPIIMAANHYWEVPKEIRDRA 150
                   R  + +DE D    N +  G  E+  LI   + PII   N     PK IR   
Sbjct: 690  AAPSVSARHALIMDEVDGMAGNEDRGGIQELIGLIKHTKIPIICMCNDR-NHPK-IRSLV 747

Query: 151  EL---VEYKRLTQRDVINALVRILKREGITVPKEVLVEIAKRASGDLRAAINDLQTVVAG 207
                 + ++R     + +A++ I  +EG+ +P   + EI   A+ D+R  +++L    A 
Sbjct: 748  HYCFDLRFQRPRVEQIKSAMLSIAFKEGLKIPPPAMNEIILGANQDVRQVLHNLSMWCAQ 807

Query: 208  G----YEDAR--YVLAYRDVEKTVFQALGLVFASDNAKRAKLAMMNLDMSPDEFL----- 256
                 Y+ A+     A +D+    F     VFA+      + A M+L    D F      
Sbjct: 808  SKALTYDQAKADSQRAKKDIRLGPFDVTRKVFAAGE----ETAHMSLMDKSDLFFHDYSI 863

Query: 257  --LWIDENIPHMYLKPEE-----------MARAYEAISKADIYLGRAQRTGNYSLWRYAI 303
              L++ EN  ++++KP             ++RA ++I   D+   + +   N+SL     
Sbjct: 864  APLFVQEN--YLHVKPVAAGGDMKKHLMLLSRAADSICDGDLVDNQIRSKQNWSL--LPT 919

Query: 304  DMMTAGVAVAGTKKRGFAKFYP--PNTL-KMLAESKEER--------------------- 339
              + A V + G   RG+   +P  P+ L K  +  K +R                     
Sbjct: 920  QAIYASV-LPGELMRGYMTQFPSFPSWLGKHSSTGKHDRIVQDLSLHMSLRTYSSKRTVN 978

Query: 340  -----STRNSIIKKIMSE-----MHMSKLEAIETMKIIKTIFEKNLDLAAHFTVFLGLSE 389
                   R+++++ + S+      H+ KL  ++T  ++K  FE  +++++        S+
Sbjct: 979  MDYLSHIRDALVRPLTSQGVEGAQHVIKL--MDTYYLMKEDFENIMEVSSWGGKPSAFSK 1036

Query: 390  KEVEFLA------GRENAGTIWGKALAIRRKLKKEEEKIRKERKEEEKVEVREEKPEEKV 443
             + +  A       +E   T +   +    +L        +  +E ++ + + EK ++ V
Sbjct: 1037 LDPKVKAAFTRAYNKEAHLTPYSLQVVKTSRLSAGPALDSEYSEEFQEDDTQSEKEQDAV 1096

Query: 444  EE----KREERETKKEKEKKEEKKAEKKGK 469
            E     K++ R +K  K ++E++  + KGK
Sbjct: 1097 ETDAMIKKKTRSSKPSKSEREKESKKGKGK 1126


>gi|6755306 replication factor C, 140 kDa [Mus musculus]
            >gi|1703056|sp|P35601|AC15_MOUSE ACTIVATOR 1 140 KDA
            SUBUNIT (REPLICATION FACTOR C LARGE SUBUNIT) (A1 140 KDA
            SUBUNIT) (RF-C 140 KDA SUBUNIT) (ACTIVATOR 1 LARGE
            SUBUNIT) (A1-P145) (DIFFERENTIATION SPECIFIC ELEMENT
            BINDING PROTEIN) (ISRE-BINDING PROTEIN)
            >gi|1083493|pir||A56200 replication factor C 140K chain -
            mouse >gi|457742|emb|CAA51260.1| (X72711) replication
            factor C [Mus musculus]
            Length = 1131
            
 Score = 92.8 bits (227), Expect = 7e-18
 Identities = 131/571 (22%), Positives = 238/571 (40%), Gaps = 120/571 (21%)

Query: 6    WVEKYRPRRLSEIINQE---DAISKVKAWIEAWLHGNPPKKK------------------ 44
            WV+KY+P  L  II Q+      +K+  W+  W   +P +KK                  
Sbjct: 570  WVDKYKPASLKNIIGQQGDQSCANKLLRWLRNWHKSSPEEKKHAAKFGKLASKDDGSSFK 629

Query: 45   ALLLAGPPGSGKTTTVYALAREYNFEVIELNASDERTYDKIARYV-QAAYTMDILG---- 99
            A LL+GPPG GKTTT   + +E  +  +ELNASD R+ + +   V ++     I G    
Sbjct: 630  AALLSGPPGVGKTTTASLVCQELGYSYVELNASDTRSKNSLKAVVAESLNNTSIKGFYTS 689

Query: 100  ------KRRKIIFLDEAD----NIEPSGAPEIAKLIDRARNPIIMAANHYWEVPKEIRDR 149
                    R  + +DE D    N +  G  E+  LI   + PII   N     PK IR  
Sbjct: 690  GAAPSVSARHALIMDEVDGMAGNEDRGGIQELIGLIKHTKIPIICMCNDR-NHPK-IRSL 747

Query: 150  AEL---VEYKRLTQRDVINALVRILKREGITVPKEVLVEIAKRASGDLRAAINDLQTVVA 206
                  + ++R     + +A++ I  +EG+ +P   + EI   A+ D+R  +++L    A
Sbjct: 748  VHYCFDLRFQRPRVEQIKSAMLSIAFKEGLKIPPPAMNEIILGANQDVRQVLHNLSMWCA 807

Query: 207  GG----YEDAR--YVLAYRDVEKTVFQALGLVFASDNAKRAKLAMMNLDMSPDEFL---- 256
                  Y+ A+     A +D+    F     VFA+      + A M+L    D F     
Sbjct: 808  QSKALTYDQAKADSQRAKKDIRLGPFDVTRKVFAAGE----ETAHMSLMDKSDLFFHDYS 863

Query: 257  ---LWIDENIPHMYLKPEE-----------MARAYEAISKADIYLGRAQRTGNYSLWRYA 302
               L++ EN  ++++KP             ++RA ++I   D+   + +   N+SL    
Sbjct: 864  IAPLFVQEN--YLHVKPVAAGGDMKKHLMLLSRAADSICDGDLVDNQIRSKQNWSL--LP 919

Query: 303  IDMMTAGVAVAGTKKRGFAKFYP--PNTL-KMLAESKEER-------------------- 339
               + A V + G   RG+   +P  P+ L K  +  K +R                    
Sbjct: 920  TQAIYASV-LPGELMRGYMTQFPSFPSWLGKHSSTGKHDRIVQDLSLHMSLRTYSSKRTV 978

Query: 340  ------STRNSIIKKIMSE-----MHMSKLEAIETMKIIKTIFEKNLDLAAHFTVFLGLS 388
                    R+++++ + S+      H+ KL  ++T  ++K  FE  +++++        S
Sbjct: 979  NMDYLSHIRDALVRPLTSQGVEGAQHVIKL--MDTYYLMKEDFENIMEVSSWGGKPSAFS 1036

Query: 389  EKEVEFLA------GRENAGTIWGKALAIRRKLKKEEEKIRKERKEEEKVEVREEKPEEK 442
            + + +  A       +E   T +   +    +L        +  +E ++ + + EK ++ 
Sbjct: 1037 KLDPKVKAAFTRAYNKEAHLTPYSLQVVKTSRLSTGPALDSEYSEEFQEDDTQSEKEQDA 1096

Query: 443  VEE----KREERETKKEKEKKEEKKAEKKGK 469
            VE     K++ R +K  K ++E++  + KGK
Sbjct: 1097 VETDAMIKKKTRSSKPSKSEREKESKKGKGK 1127


>gb|AAF07781.1|AC010704_6 (AC010704) putative replication factor C; 24844-22715 [Arabidopsis
           thaliana]
           Length = 369
           
 Score = 92.4 bits (226), Expect = 9e-18
 Identities = 63/209 (30%), Positives = 105/209 (50%), Gaps = 16/209 (7%)

Query: 5   PWVEKYRPRRLSEIINQEDAISKVKAWIEAWLHGNPPKKKALLLAGPPGSGKTTTVYALA 64
           PWVEKYRP+ L ++    D I  +          N  K   LLL GPPG+GKT+T+ A+A
Sbjct: 40  PWVEKYRPQSLDDVAAHRDIIDTIDRLT------NENKLPHLLLYGPPGTGKTSTILAVA 93

Query: 65  R-----EYNFEVIELNASDERTYDKIARYVQ--AAYTMDILGKRR-KIIFLDEADNIEPS 116
           R     +Y   ++ELNASD+R  D + + +Q  A+     LGK   K++ LDEAD +   
Sbjct: 94  RKLYGPKYRNMILELNASDDRGIDVVRQQIQDFASTQSFSLGKSSVKLVLLDEADAMTKD 153

Query: 117 GAPEIAKLIDR--ARNPIIMAANHYWEVPKEIRDRAELVEYKRLTQRDVINALVRILKRE 174
               + ++I++        +  NH  ++   ++ R     +  L    +   L  +++ E
Sbjct: 154 AQFALRRVIEKYTKSTRFALIGNHVNKIIPALQSRCTRFRFAPLDGVHMSQRLKHVIEAE 213

Query: 175 GITVPKEVLVEIAKRASGDLRAAINDLQT 203
            + V    L  + + ++GD+R A+N LQ+
Sbjct: 214 RLVVSDCGLAALVRLSNGDMRKALNILQS 242


>dbj|BAB16441.1| (AB045677) replication factor C 37kDa subunit [Oryza sativa]
           Length = 339
           
 Score = 92.4 bits (226), Expect = 9e-18
 Identities = 58/215 (26%), Positives = 106/215 (48%), Gaps = 22/215 (10%)

Query: 5   PWVEKYRPRRLSEIINQEDAISKVKAWIEAWLHGNPPKKKALLLAGPPGSGKTTTVYALA 64
           PWVEKYRPR++ ++ +QE+ +  +   ++            +L  GPPG+GKTTT  A+A
Sbjct: 10  PWVEKYRPRQVKDVAHQEEVVRVLTTTLQT------ADLPHMLFYGPPGTGKTTTALAIA 63

Query: 65  RE------YNFEVIELNASDERTYDKIARYVQAAYTMDILGKRR--------KIIFLDEA 110
            +      Y   V+ELNASD+R  + +   ++    + +   R+        KII LDEA
Sbjct: 64  YQLYGPELYKSRVLELNASDDRGINVVRTKIKDFAAVAVGSARKGGYPCPPYKIIILDEA 123

Query: 111 DNIEPSGAPEIAKLIDRARNP--IIMAANHYWEVPKEIRDRAELVEYKRLTQRDVINALV 168
           D++       + + ++            N+   + + +  R     +K L++  + N ++
Sbjct: 124 DSMTEDAQNALRRTMETYSKVTRFFFICNYISRIIEPLASRCAKFRFKPLSEEVMSNRIL 183

Query: 169 RILKREGITVPKEVLVEIAKRASGDLRAAINDLQT 203
            I   EG+++  + L  ++  ++GDLR AI  LQ+
Sbjct: 184 HICNEEGLSLDAQALATLSTISNGDLRRAITYLQS 218


>gb|AAC52140.1| (U07157) ISRE-binding protein [Mus musculus]
            Length = 1145
            
 Score = 92.1 bits (225), Expect = 1e-17
 Identities = 132/569 (23%), Positives = 238/569 (41%), Gaps = 118/569 (20%)

Query: 6    WVEKYRPRRLSEIINQE---DAISKVKAWIEAWLHGNPPKKK-----------------A 45
            WV+KY+P  L  II Q+      +K+  W+  W   +P +KK                 A
Sbjct: 584  WVDKYKPASLKNIIGQQGDQSCANKLLRWLRNWHKSSPEEKKHAKFGKLASKDDGSSFKA 643

Query: 46   LLLAGPPGSGKTTTVYALAREYNFEVIELNASDERTYDKIARYV-QAAYTMDILG----- 99
             LL+GPPG GKTTT   + +E  +  +ELNASD R+ + +   V ++     I G     
Sbjct: 644  ALLSGPPGVGKTTTASLVCQELGYSYVELNASDTRSKNSLKAVVAESLNNTSIKGFYTSG 703

Query: 100  -----KRRKIIFLDEAD----NIEPSGAPEIAKLIDRARNPIIMAANHYWEVPKEIRDRA 150
                   R  + +DE D    N +  G  E+  LI   + PII   N     PK IR   
Sbjct: 704  AAPSVSARHALIMDEVDGMAGNEDRGGIQELIGLIKHTKIPIICMCNDR-NHPK-IRSLV 761

Query: 151  EL---VEYKRLTQRDVINALVRILKREGITVPKEVLVEIAKRASGDLRAAINDLQTVVAG 207
                 + ++R     + +A++ I  +EG+ +P   + EI   A+ D+R  +++L    A 
Sbjct: 762  HYCFDLRFQRPRVEQIKSAMLSIAFKEGLKIPPPAMNEIILGANQDVRQVLHNLSMWCAQ 821

Query: 208  G----YEDAR--YVLAYRDVEKTVFQALGLVFASDNAKRAKLAMMNLDMSPDEFL----- 256
                 Y+ A+     A +D+    F     VFA+      + A M+L    D F      
Sbjct: 822  SKALTYDQAKADSQRAKKDIRLGPFDVTRKVFAAGE----ETAHMSLMDKSDLFFHDYSI 877

Query: 257  --LWIDENIPHMYLKPEE-----------MARAYEAISKADIYLGRAQRTGNYSLWRYAI 303
              L++ EN  ++++KP             ++RA ++I   D+   + +   N+SL     
Sbjct: 878  APLFVQEN--YLHVKPVAAGGDMKKHLMLLSRAADSICDGDLVDNQIRSKQNWSL--LPT 933

Query: 304  DMMTAGVAVAGTKKRGFAKFYP--PNTL-KMLAESKEER--------------------- 339
              + A V + G   RG+   +P  P+ L K  +  K +R                     
Sbjct: 934  QAIYASV-LPGELMRGYMTQFPSFPSWLGKHSSTGKHDRIVQDLSLHMSLRTYSSKRTVN 992

Query: 340  -----STRNSIIKKIMSE-----MHMSKLEAIETMKIIKTIFEKNLDLAAHFTVFLGLSE 389
                   R+++++ + S+      H+ KL  ++T  ++K  FE  +++++        S+
Sbjct: 993  MDYLSHIRDALVRPLTSQGVEGAQHVIKL--MDTYYLMKEDFENIMEVSSWGGKPSAFSK 1050

Query: 390  KEVEFLA------GRENAGTIWGKALAIRRKLKKEEEKIRKERKEEEKVEVREEKPEEKV 443
             + +  A       +E   T +   +    +L        +  +E ++ + + EK ++ V
Sbjct: 1051 LDPKVKAAFTRAYNKEAHLTPYSLQVVKTSRLSTGPALDSEYSEEFQEDDTQSEKEQDAV 1110

Query: 444  EEKR--EERETKKEKEKKEEKKAE-KKGK 469
            E     ++++T+  K  K E++ E KKGK
Sbjct: 1111 ETDAMIKQKKTRSSKPSKSEREKESKKGK 1139


>gb|AAD41422.1|AC007727_11 (AC007727) Similar to gb|M87339 replication factor C, 37-kDa
           subunit from Homo sapiens and is a member of PF|00004
           ATPases associated with various cellular activities.
           [Arabidopsis thaliana]
           Length = 319
           
 Score = 91.7 bits (224), Expect = 2e-17
 Identities = 60/217 (27%), Positives = 106/217 (48%), Gaps = 23/217 (10%)

Query: 5   PWVEKYRPRRLSEIINQEDAISKVKAWIEAWLHGNPPKKKALLLAGPPGSGKTTTVYALA 64
           PWVEKYRP+++ ++ +QE+ +  +   ++     + P    +L  GPPG+GKTTT  A+A
Sbjct: 10  PWVEKYRPKQVKDVAHQEEVVRVLTNTLQT---ADCPH---MLFYGPPGTGKTTTALAIA 63

Query: 65  RE------YNFEVIELNASDERTYDKIARYVQAAYTMDILGKRR---------KIIFLDE 109
            +      Y   V+ELNASD+R  + +   ++    + +    R         KII LDE
Sbjct: 64  HQLFGPELYKSRVLELNASDDRGINVVRTKIKDFAAVAVGSNHRQSGYPCPSFKIIILDE 123

Query: 110 ADNIEPSGAPEIAKLIDRARNP--IIMAANHYWEVPKEIRDRAELVEYKRLTQRDVINAL 167
           AD++       + + ++            N+   + + +  R     +K L++  + N +
Sbjct: 124 ADSMTEDAQNALRRTMETYSKVTRFFFICNYISRIIEPLASRCAKFRFKPLSEEVMSNRI 183

Query: 168 VRILKREGITVPKEVLVEIAKRASGDLRAAINDLQTV 204
           + I   EG+++  E L  ++  + GDLR AI  LQ V
Sbjct: 184 LHICNEEGLSLDGEALSTLSSISQGDLRRAITYLQVV 220


>gb|AAD01890.1| (AF030050) replication factor C [Rattus norvegicus]
           Length = 1104
           
 Score = 90.9 bits (222), Expect = 3e-17
 Identities = 90/351 (25%), Positives = 151/351 (42%), Gaps = 62/351 (17%)

Query: 6   WVEKYRPRRLSEIINQE---DAISKVKAWIEAWLHGNPPKKK-----------------A 45
           WV+KY+P  L  II Q+      +K+  W+  W   +P +KK                 A
Sbjct: 570 WVDKYKPTSLKNIIGQQGDQSCANKLLRWLRNWHKSSPEEKKHAKFGKVASKDDGSSFKA 629

Query: 46  LLLAGPPGSGKTTTVYALAREYNFEVIELNASDERTYDKIARYV-QAAYTMDILG----- 99
            LL+GPPG GKTTT   + +E  +  +ELNASD R+ + +   V ++     I G     
Sbjct: 630 ALLSGPPGVGKTTTASLVCQELGYSYVELNASDTRSKNSLKAIVAESLNNTSIKGFYTSG 689

Query: 100 -----KRRKIIFLDEAD----NIEPSGAPEIAKLIDRARNPIIMAANHYWEVPKEIRDRA 150
                  R  + +DE D    N +  G  E+  LI   + PII   N     PK IR   
Sbjct: 690 ASPSVSARHALIMDEVDGMAGNEDRGGIQELIGLIKHTKIPIICMCNDR-NHPK-IRSLV 747

Query: 151 EL---VEYKRLTQRDVINALVRILKREGITVPKEVLVEIAKRASGDLRAAINDLQTVVAG 207
                + ++R     + +A++ I  +EG+ +P   + EI   A+ D+R  +++L    A 
Sbjct: 748 HYCFDLRFQRPRVEQIKSAMLSIAFKEGLKIPPPAMNEIILGANQDVRQVLHNLSMWCAQ 807

Query: 208 G----YEDAR--YVLAYRDVEKTVFQALGLVFASDNAKRAKLAMMNLDMSPDEFL---LW 258
                Y+ A+     A +D+    F     VFA+         M   D+   ++    L+
Sbjct: 808 SKVLTYDQAKADSQRAKKDIRLGPFDVTRKVFAAGEETPHMSLMDKSDLFFHDYSIAPLF 867

Query: 259 IDENIPHMYLKPEE-----------MARAYEAISKADIYLGRAQRTGNYSL 298
           + EN  ++++KP             ++RA ++I   D+   + +   N+SL
Sbjct: 868 VQEN--YLHVKPVAAGGDMKKHLMLLSRAADSICDGDLVANQIRSKQNWSL 916


>gb|AAG37985.1|AF069296_1 (AF069296) replication factor C3 [Plasmodium falciparum]
           Length = 344
           
 Score = 90.1 bits (220), Expect = 5e-17
 Identities = 65/212 (30%), Positives = 110/212 (51%), Gaps = 18/212 (8%)

Query: 5   PWVEKYRPRRLSEIINQEDAISKVKAWIEAWLHGNPPKKKALLLAGPPGSGKTTTVYALA 64
           PWVEKYRP  L++II+ E  IS +K +++    G  P    LLL GPPG+GKT+T+ A+ 
Sbjct: 14  PWVEKYRPNVLNDIISHEQVISTIKRFVQ---KGELPH---LLLHGPPGTGKTSTILAVC 67

Query: 65  REYNFE-----VIELNASDER----TYDKIARYVQAAYTMDILGKRR-KIIFLDEADNIE 114
           +E   +     V+ELNASD+R      D+I  + ++        K   K+I LDEAD++ 
Sbjct: 68  KELYGDKRSSFVLELNASDDRGINVIRDQIKTFAESKNHYTTCEKTTLKLIILDEADHMT 127

Query: 115 PSGAPEIAKLIDR-ARN-PIIMAANHYWEVPKEIRDRAELVEYKRLTQRDVINALVRILK 172
                 + ++++  A+N    +  N+  ++   I+ R     +  L +  + N  + I K
Sbjct: 128 YPAQNAMRRIMENYAKNVRFCLLCNYVNKITPAIQSRCTAFRFAPLKKEYMKNKALDIAK 187

Query: 173 REGITVPKEVLVEIAKRASGDLRAAINDLQTV 204
            E + + +  +  + +   GD+R  +N LQ V
Sbjct: 188 SENVNLTEGGIDSLIRVGHGDMRRILNCLQVV 219


>gb|AAC60361.1| (U60144) replication factor C large subunit [Anas platyrhynchos]
           Length = 1145
           
 Score = 89.7 bits (219), Expect = 6e-17
 Identities = 108/411 (26%), Positives = 175/411 (42%), Gaps = 75/411 (18%)

Query: 6   WVEKYRPRRLSEIINQE---DAISKVKAWIEAWLHGNPPK-----------------KKA 45
           WV+KY+P  L  II Q+      +K+  W+  W H N  +                  KA
Sbjct: 582 WVDKYKPTSLKAIIGQQGEQSCANKLLRWLRNW-HKNTSEDGQAKASKLGGKDDGISSKA 640

Query: 46  LLLAGPPGSGKTTTVYALAREYNFEVIELNASDERTYDKIARYVQ------------AAY 93
            LL+GPPG GKTTT   + +E  +  +ELNASD R+ + +   V             +  
Sbjct: 641 ALLSGPPGVGKTTTAALVCKELGYSYVELNASDTRSKNSLKEVVAESLNNTSIKDFCSGT 700

Query: 94  TMDILGKRRKIIFLDEAD----NIEPSGAPEIAKLIDRARNPIIMAANHYWEVPKEIRDR 149
           +  + GK   ++ +DE D    N +  G  E+  LI   + PII   N     PK IR  
Sbjct: 701 SSSVSGKH--VLIMDEVDGMAGNEDRGGIQELISLIKHTKIPIICMCNDR-NHPK-IRSL 756

Query: 150 AEL---VEYKRLTQRDVINALVRILKREGITVPKEVLVEIAKRASGDLRAAINDLQTVVA 206
                 + ++R     +  A++ I  +EG+ +P   + EI   A+ D+R  +++L    A
Sbjct: 757 VHYCFDLRFQRPRLEQIKGAMMSIAFKEGLKIPPPAMHEIILAANQDIRQVLHNLNMWCA 816

Query: 207 GG----YEDAR--YVLAYRDVEKTVFQALGLVFAS-DNAKRAKLAMMNLDMSPDEFL--L 257
                 Y++A+     A +D++   F  +  VFA+ + A R  L   +     D  L  L
Sbjct: 817 KDKSLTYDEAKTDASRAKKDIKLGPFDVVRKVFAAGEEASRMSLIDKSDLFFHDYSLAPL 876

Query: 258 WIDENIPHMY-------LKPEEM--ARAYEAISKADIYLGRAQRTGNYSLWRYAIDMMTA 308
           ++ EN  H+        LK   M  +RA ++I   D+   + +   N   W         
Sbjct: 877 FVQENYVHVKTAAAGGDLKKHLMLLSRAADSICDGDLVDRQIRSKQN---WNLLPTQAIY 933

Query: 309 GVAVAGTKKRGFAKFYP--PNTL-KMLAESKEERSTRNSIIKKIMSEMHMS 356
              + G   RG+   +P  P+ L K  +  K ER     I++++   MHMS
Sbjct: 934 SSVLPGELMRGYMSQFPVFPSWLGKFSSTGKHER-----IVQEL--AMHMS 977


>pir||D72344 DNA polymerase III, gamma and tau subunit - Thermotoga maritima
           (strain MSB8) >gi|4981209|gb|AAD35768.1|AE001741_1
           (AE001741) DNA polymerase III, gamma and tau subunit
           [Thermotoga maritima]
           Length = 478
           
 Score = 89.7 bits (219), Expect = 6e-17
 Identities = 115/483 (23%), Positives = 202/483 (41%), Gaps = 70/483 (14%)

Query: 9   KYRPRRLSEIINQEDAISKVKAWIE--AWLHGNPPKKKALLLAGPPGSGKTTTVYALARE 66
           KYRP+  SE++NQ+     +   I+  +  HG        + AGP G+GKTT    LA+ 
Sbjct: 7   KYRPKTFSEVVNQDHVKKAIIGAIQKNSVAHG-------YIFAGPRGTGKTTLARILAKS 59

Query: 67  YNFE------------------------VIELNASDERTYDKIARYVQAAYTMDILGKRR 102
            N E                        VIEL+A+  R  D+I R   A     + GK  
Sbjct: 60  LNCENRKGVEPCNSCRACREIDEGTFMDVIELDAASNRGIDEIRRIRDAVGYRPMEGKY- 118

Query: 103 KIIFLDEADNIEPSGAPEIAKLIDRARNPII--MAANHYWEVPKEIRDRAELVEYKRLTQ 160
           K+  +DE   +       + K ++   + ++  +A  +  +VP  I  R ++ E++ +  
Sbjct: 119 KVYIIDEVHMLTKEAFNALLKTLEEPPSHVVFVLATTNLEKVPPTIISRCQVFEFRNIPD 178

Query: 161 RDVINALVRILKREGITVPKEVLVEIAKRASGDLRAAINDLQTVVAGGYEDARYVLAYRD 220
             +   L  + + EGI + +E L  IAKRASG LR A+  L+ V    + + +  L    
Sbjct: 179 ELIEKRLQEVAEAEGIEIDREALSFIAKRASGGLRDALTMLEQV--WKFSEGKIDL---- 232

Query: 221 VEKTVFQALGLV-----------FASDNAKRAKLAMMNLDMSPDEFLLWIDENIPHMYLK 269
             +TV +ALGL+             S + KR    + ++  S  ++ + I E +  + ++
Sbjct: 233 --ETVHRALGLIPIQVVRDYVNAIFSGDVKRVFTVLDDVYYSGKDYEVLIQEAVEDL-VE 289

Query: 270 PEEMARAYEAISKADIYLGRAQRTGNYSLWRYAID---MMTAGVAVAGTKKRGFAKFYPP 326
             E  R    +S  DI     Q        ++A +   +   G A   T      +F   
Sbjct: 290 DLERERGVYQVSANDIVQVSRQLLNLLREIKFAEEKRLVCKVGSAYIAT------RFSTT 343

Query: 327 NTLKM-LAESKEERSTRNSIIKKIMSEMHMSKLEAIETMKIIKTIFEKNLDLAAHFTVFL 385
           N  +  + E  +  + +    KK   +    K E  E  K  K + E+ L      ++F+
Sbjct: 344 NVQENDVREKNDNSNVQQKEEKKETVKAKEEKQEDSEFEKRFKELMEE-LKEKGDLSIFV 402

Query: 386 GLSEKEVEFLAGRENAGTIWGKAL---AIRRKLKKEEEKIRKERKEEEKVEVREEKPEEK 442
            LS  EV+F   +        KA+    +++KL + E    ++  ++ +VE+R    EE 
Sbjct: 403 ALSLSEVQFDGEKVIISFDSSKAMHYELMKKKLPELENIFSRKLGKKVEVELRLMGKEET 462

Query: 443 VEE 445
           +E+
Sbjct: 463 IEK 465


>gi|6322528 Subunit 2 of Replication Factor C; homologous to human RFC 37 kDa
           subunit; Rfc2p [Saccharomyces cerevisiae]
           >gi|730502|sp|P40348|RFC2_YEAST ACTIVATOR 1 41 KD
           SUBUNIT (REPLICATION FACTOR C 41 KD SUBUNIT)
           >gi|626873|pir||S45531 replication factor C chain RFC2 -
           yeast (Saccharomyces cerevisiae)
           >gi|498463|dbj|BAA05858.1| (D28499) Rfc2 protein
           [Saccharomyces cerevisiae] >gi|841464|gb|AAC49061.1|
           (U26028) Rfc2p [Saccharomyces cerevisiae]
           >gi|1015747|emb|CAA89596.1| (Z49568) ORF YJR068w
           [Saccharomyces cerevisiae] >gi|1019690|gb|AAB39294.1|
           (L47993) ORF YJR068w [Saccharomyces cerevisiae]
           Length = 353
           
 Score = 88.5 bits (216), Expect = 1e-16
 Identities = 72/255 (28%), Positives = 118/255 (46%), Gaps = 29/255 (11%)

Query: 1   MPEVPWVEKYRPRRLSEIINQEDAISKVKAWIEAWLHGNPPKKKALLLAGPPGSGKTTTV 60
           + + PWVEKYRP+ L E+  Q+ A++ +K  +++    N P    +L  GPPG+GKT+T+
Sbjct: 22  LAQQPWVEKYRPKNLDEVTAQDHAVTVLKKTLKS---ANLPH---MLFYGPPGTGKTSTI 75

Query: 61  YALARE------YNFEVIELNASDERTYDKIARYVQ--AAYTMDILGKR---------RK 103
            AL +E          ++ELNASDER    +   V+  A  T+    K           K
Sbjct: 76  LALTKELYGPDLMKSRILELNASDERGISIVREKVKNFARLTVSKPSKHDLENYPCPPYK 135

Query: 104 IIFLDEADNIEPSGAPEIAKLID--RARNPIIMAANHYWEVPKEIRDRAELVEYKRLTQR 161
           II LDEAD++       + + ++         +  N+   +   +  R     +K L   
Sbjct: 136 IIILDEADSMTADAQSALRRTMETYSGVTRFCLICNYVTRIIDPLASRCSKFRFKALDAS 195

Query: 162 DVINALVRILKREGITVPKEVLVEIAKRASGDLRAAINDLQTVVAGGYEDARYVLAYRDV 221
           + I+ L  I ++E +     VL  I   ++GDLR  I  LQ+   G    A+Y+   +++
Sbjct: 196 NAIDRLRFISEQENVKCDDGVLERILDISAGDLRRGITLLQSASKG----AQYLGDGKNI 251

Query: 222 EKTVFQALGLVFASD 236
             T  + L  V   D
Sbjct: 252 TSTQVEELAGVVPHD 266


>gb|AAF69583.1|AC019154_2 (AC019154) Replication Factor C [Leishmania major]
           Length = 364
           
 Score = 87.0 bits (212), Expect = 4e-16
 Identities = 74/308 (24%), Positives = 138/308 (44%), Gaps = 49/308 (15%)

Query: 4   VPWVEKYRPRRLSEIINQEDAISKVKAWIEAWLHGNPPKKKALLLAGPPGSGKTTTVYAL 63
           +PWVEKYRP  L  ++  ED +S ++  +++   GN P    LLL GPPG+GKTTT+ A 
Sbjct: 17  LPWVEKYRPSTLESVVAHEDILSTLRHLMDS---GNMPH---LLLYGPPGTGKTTTIKAC 70

Query: 64  A------REYNFEVIELNASDERTYDKIAR----YVQAAYTMDILG-------------K 100
           A            V+E+NASD+R  D + +    +   +    ++G              
Sbjct: 71  AYYLYGKARVRANVLEMNASDDRGIDVVRQQTREFASTSSIFSMMGTGSSTGGGSGGPAA 130

Query: 101 RRKIIFLDEADNIEPSGAPEIAKLIDR-ARN-PIIMAANHYWEVPKEIRDRAELVEYKRL 158
           + K++ LDEAD +       + ++I++  RN    +  NH  ++   ++ R     +  +
Sbjct: 131 KFKLVILDEADQMSHDAQAALRRVIEKYTRNVRFCILCNHINKIIPALQSRCTRFRFAPV 190

Query: 159 TQRDVINALVRILKREGITVPKEVLVEIAKRASGDLRAAINDLQTVVAGGYEDARYVLAY 218
            +  ++  L  + ++EG+    + L    + + GDLR  +N +Q         A  + A 
Sbjct: 191 KKSSMMPRLRYVAEQEGVKYTTDGLAAAFRLSHGDLRRCLNTMQ---------ASALSAN 241

Query: 219 RDVEKTVFQALGLVFASDNAKRAKLAMMNLDMSPDEFLL-WI--DENIPHMYLKPEEMAR 275
              E++V++  G      N   A +  +  DM   +F   W+  +E++    +   ++ R
Sbjct: 242 EITEESVYRVTG------NPTPADVTAIVSDMLSSDFATSWVKAEESVVQKGISMADLTR 295

Query: 276 AYEAISKA 283
               +  A
Sbjct: 296 EIHPVMMA 303


>gi|4506485 replication factor C (activator 1) 1 (145kD) [Homo sapiens]
            >gi|2136100|pir||A49651 replication factor C large
            subunit - human >gi|410218|gb|AAA16121.1| (L23320)
            replication factor C large subunit [Homo sapiens]
            Length = 1148
            
 Score = 84.7 bits (206), Expect = 2e-15
 Identities = 135/568 (23%), Positives = 230/568 (39%), Gaps = 115/568 (20%)

Query: 6    WVEKYRPRRLSEIINQE---DAISKVKAWIEAWLHGNPPKKK------------------ 44
            WV+KY+P  L  II Q+      +K+  W+  W   +   KK                  
Sbjct: 586  WVDKYKPTSLKTIIGQQGDQSCANKLLRWLRNWQKSSSEDKKHAAKFGKFSGKDDGSSFK 645

Query: 45   ALLLAGPPGSGKTTTVYALAREYNFEVIELNASDERTYDKIARYV-QAAYTMDILG---- 99
            A LL+GPPG GKTTT   + +E  +  +ELNASD R+   +   V ++     I G    
Sbjct: 646  AALLSGPPGVGKTTTASLVCQELGYSYVELNASDTRSKSSLKAIVAESLNNTSIKGFYSN 705

Query: 100  ------KRRKIIFLDEAD----NIEPSGAPEIAKLIDRARNPIIMAANHYWEVPKEIRDR 149
                    +  + +DE D    N +  G  E+  LI   + PII   N     PK IR  
Sbjct: 706  GAASSVSTKHALIMDEVDGMAGNEDRGGIQELIGLIKHTKIPIICMCNDR-NHPK-IRSL 763

Query: 150  AEL---VEYKRLTQRDVINALVRILKREGITVPKEVLVEIAKRASGDLRAAINDLQTVVA 206
                  + ++R     +  A++ I  +EG+ +P   + EI   A+ D+R  +++L    A
Sbjct: 764  VHYCFDLRFQRPRVEQIKGAMMSIAFKEGLKIPPPAMNEIILGANQDIRQVLHNLSMWCA 823

Query: 207  GG----YEDAR--YVLAYRDVEKTVFQALGLVFASDNAKRAKLAMMNLDMSPDEFL---- 256
                  Y+ A+     A +D++   F     VFA+      + A M+L    D F     
Sbjct: 824  RSKALTYDQAKADSHRAKKDIKMGPFDVARKVFAAGE----ETAHMSLVDKSDLFFHDYS 879

Query: 257  ---LWIDENIPHMYLKPEE-----------MARAYEAISKADIYLGRAQRTGNYSLWRYA 302
               L++ EN  ++++KP             ++RA ++I   D+   + +   N+SL    
Sbjct: 880  IAPLFVQEN--YIHVKPVAAGGDMKKHLMLLSRAADSICDGDLVDSQIRSKQNWSL--LP 935

Query: 303  IDMMTAGVAVAGTKKRGFAKFYP--PNTL-KMLAESKEER---------STRNSIIKKIM 350
               + A V + G   RG+   +P  P+ L K  +  K +R         S R    K+ +
Sbjct: 936  AQAIYASV-LPGELMRGYMTQFPTFPSWLGKHSSTGKHDRIVQDLALHMSLRTYSSKRTV 994

Query: 351  SEMHMSKLE--------------------AIETMKIIKTIFEKNLDLAA---HFTVFLGL 387
            +  ++S L                      ++T  ++K  FE  +++++     + F  L
Sbjct: 995  NMDYLSLLRDALVQPLTSQGVDGVQDVVALMDTYYLMKEDFENIMEISSWGGKPSPFSKL 1054

Query: 388  SEK-EVEFLAGRENAGTIWGKAL-AIRRKLKKEEEKIRKERKEE--EKVEVREEKPEEKV 443
              K +  F         +   +L AI+         +  E  EE  E     +EK ++ +
Sbjct: 1055 DPKVKAAFTRAYNKEAHLTPYSLQAIKASRHSTSPSLDSEYNEELNEDDSQSDEKDQDAI 1114

Query: 444  E-EKREERETKKEKEKKEEK-KAEKKGK 469
            E +   +++TK  K  K EK K  +KGK
Sbjct: 1115 ETDAMIKKKTKSSKPSKPEKDKEPRKGK 1142


>gi|11435908 replication factor C (activator 1) 1 (145kD) [Homo sapiens]
            Length = 1032
            
 Score = 84.7 bits (206), Expect = 2e-15
 Identities = 135/568 (23%), Positives = 230/568 (39%), Gaps = 115/568 (20%)

Query: 6    WVEKYRPRRLSEIINQE---DAISKVKAWIEAWLHGNPPKKK------------------ 44
            WV+KY+P  L  II Q+      +K+  W+  W   +   KK                  
Sbjct: 470  WVDKYKPTSLKTIIGQQGDQSCANKLLRWLRNWQKSSSEDKKHAAKFGKFSGKDDGSSFK 529

Query: 45   ALLLAGPPGSGKTTTVYALAREYNFEVIELNASDERTYDKIARYV-QAAYTMDILG---- 99
            A LL+GPPG GKTTT   + +E  +  +ELNASD R+   +   V ++     I G    
Sbjct: 530  AALLSGPPGVGKTTTASLVCQELGYSYVELNASDTRSKSSLKAIVAESLNNTSIKGFYSN 589

Query: 100  ------KRRKIIFLDEAD----NIEPSGAPEIAKLIDRARNPIIMAANHYWEVPKEIRDR 149
                    +  + +DE D    N +  G  E+  LI   + PII   N     PK IR  
Sbjct: 590  GAASSVSTKHALIMDEVDGMAGNEDRGGIQELIGLIKHTKIPIICMCNDR-NHPK-IRSL 647

Query: 150  AEL---VEYKRLTQRDVINALVRILKREGITVPKEVLVEIAKRASGDLRAAINDLQTVVA 206
                  + ++R     +  A++ I  +EG+ +P   + EI   A+ D+R  +++L    A
Sbjct: 648  VHYCFDLRFQRPRVEQIKGAMMSIAFKEGLKIPPPAMNEIILGANQDIRQVLHNLSMWCA 707

Query: 207  GG----YEDAR--YVLAYRDVEKTVFQALGLVFASDNAKRAKLAMMNLDMSPDEFL---- 256
                  Y+ A+     A +D++   F     VFA+      + A M+L    D F     
Sbjct: 708  RSKALTYDQAKADSHRAKKDIKMGPFDVARKVFAAGE----ETAHMSLVDKSDLFFHDYS 763

Query: 257  ---LWIDENIPHMYLKPEE-----------MARAYEAISKADIYLGRAQRTGNYSLWRYA 302
               L++ EN  ++++KP             ++RA ++I   D+   + +   N+SL    
Sbjct: 764  IAPLFVQEN--YIHVKPVAAGGDMKKHLMLLSRAADSICDGDLVDSQIRSKQNWSL--LP 819

Query: 303  IDMMTAGVAVAGTKKRGFAKFYP--PNTL-KMLAESKEER---------STRNSIIKKIM 350
               + A V + G   RG+   +P  P+ L K  +  K +R         S R    K+ +
Sbjct: 820  AQAIYASV-LPGELMRGYMTQFPTFPSWLGKHSSTGKHDRIVQDLALHMSLRTYSSKRTV 878

Query: 351  SEMHMSKLE--------------------AIETMKIIKTIFEKNLDLAA---HFTVFLGL 387
            +  ++S L                      ++T  ++K  FE  +++++     + F  L
Sbjct: 879  NMDYLSLLRDALVQPLTSQGVDGVQDVVALMDTYYLMKEDFENIMEISSWGGKPSPFSKL 938

Query: 388  SEK-EVEFLAGRENAGTIWGKAL-AIRRKLKKEEEKIRKERKEE--EKVEVREEKPEEKV 443
              K +  F         +   +L AI+         +  E  EE  E     +EK ++ +
Sbjct: 939  DPKVKAAFTRAYNKEAHLTPYSLQAIKASRHSTSPSLDSEYNEELNEDDSQSDEKDQDAI 998

Query: 444  E-EKREERETKKEKEKKEEK-KAEKKGK 469
            E +   +++TK  K  K EK K  +KGK
Sbjct: 999  ETDAMIKKKTKSSKPSKPEKDKEPRKGK 1026


>sp|P35251|AC15_HUMAN ACTIVATOR 1 140 KDA SUBUNIT (REPLICATION FACTOR C LARGE SUBUNIT) (A1
            140 KDA SUBUNIT) (RF-C 140 KDA SUBUNIT) (ACTIVATOR 1
            LARGE SUBUNIT) (DNA-BINDING PROTEIN PO-GA)
            >gi|422807|pir||JN0599 DNA-binding protein PO-GA - human
            >gi|296908|emb|CAA80355.1| (Z22642) PO-GA [Homo sapiens]
            >gi|307338|gb|AAA86853.1| (L14922) DNA-binding protein
            [Homo sapiens] >gi|2827257|gb|AAB99788.1| (AF040250) DNA
            binding protein [Homo sapiens]
            Length = 1147
            
 Score = 84.3 bits (205), Expect = 3e-15
 Identities = 135/567 (23%), Positives = 229/567 (39%), Gaps = 114/567 (20%)

Query: 6    WVEKYRPRRLSEIINQE---DAISKVKAWIEAWLHGNPPKKK-----------------A 45
            WV+KY+P  L  II Q+      +K+  W+  W   +   KK                 A
Sbjct: 586  WVDKYKPTSLKTIIGQQGDQSCANKLLLWLRNWQKSSSEDKKHSKFGKFSGKDDNSSFKA 645

Query: 46   LLLAGPPGSGKTTTVYALAREYNFEVIELNASDERTYDKIARYV-QAAYTMDILG----- 99
             LL+GPPG GKTTT   + +E  +  +ELN SD R+   +   V ++     I G     
Sbjct: 646  ALLSGPPGVGKTTTASLVCQELGYSYVELNRSDTRSKSSLKAIVAESLNNTSIKGFYSNG 705

Query: 100  -----KRRKIIFLDEAD----NIEPSGAPEIAKLIDRARNPIIMAANHYWEVPKEIRDRA 150
                   +  + +DE D    N +  G  E+  LI   + PII   N     PK IR   
Sbjct: 706  AASSVSTKHALIMDEVDGMAGNEDRGGIQELIGLIKHTKIPIICMCNDR-NHPK-IRSLV 763

Query: 151  EL---VEYKRLTQRDVINALVRILKREGITVPKEVLVEIAKRASGDLRAAINDLQTVVAG 207
                 + ++R     +  A++ I  +EG+ +P   + EI   A+ D+R  +++L    A 
Sbjct: 764  HYCFDLRFQRPRVEQIKGAMMSIAFKEGLKIPPPAMNEIILGANQDIRQVLHNLSMWCAR 823

Query: 208  G----YEDAR--YVLAYRDVEKTVFQALGLVFASDNAKRAKLAMMNLDMSPDEFL----- 256
                 Y+ A+     A +D++   F     VFA+      + A M+L    D F      
Sbjct: 824  SKALTYDQAKADSHRAKKDIKMGPFDVARKVFAAGE----ETAHMSLVDKSDLFFHDYSI 879

Query: 257  --LWIDENIPHMYLKPEE-----------MARAYEAISKADIYLGRAQRTGNYSLWRYAI 303
              L++ EN  ++++KP             ++RA ++I   D+   + +   N+SL     
Sbjct: 880  APLFVQEN--YIHVKPVAAGGDMKKHLMLLSRAADSICDGDLVDSQIRSKQNWSL--LPA 935

Query: 304  DMMTAGVAVAGTKKRGFAKFYP--PNTL-KMLAESKEER---------STRNSIIKKIMS 351
              + A V + G   RG+   +P  P+ L K  +  K +R         S R    K+ ++
Sbjct: 936  QAIYASV-LPGELMRGYMTQFPTFPSWLGKHSSTGKHDRIVQDLALHMSLRTYSSKRTVN 994

Query: 352  EMHMSKLE--------------------AIETMKIIKTIFEKNLDLAA---HFTVFLGLS 388
              ++S L                      ++T  ++K  FE  +++++     + F  L 
Sbjct: 995  MDYLSLLRDALVQPLTSQGVDGVQDVVALMDTYYLMKEDFENIMEISSWGGKPSPFSKLD 1054

Query: 389  EK-EVEFLAGRENAGTIWGKAL-AIRRKLKKEEEKIRKERKEE--EKVEVREEKPEEKVE 444
             K +  F         +   AL AI+         +  E  EE  E     +EK ++ +E
Sbjct: 1055 PKVKAAFTRAYNKEAHLTPYALQAIKASRHSTSPSLDSEYNEELNEDDSQSDEKDQDAIE 1114

Query: 445  -EKREERETKKEKEKKEEK-KAEKKGK 469
             +   +++TK  K  K EK K  +KGK
Sbjct: 1115 TDAMIKKKTKSSKPSKPEKDKEPRKGK 1141


>sp|Q09843|RFC2_SCHPO PROBABLE ACTIVATOR 1 41 KD SUBUNIT (REPLICATION FACTOR C 41 KD
           SUBUNIT) >gi|2130334|pir||S62493 replication factor C
           activator 1 41 kd subunit - fission yeast
           (Schizosaccharomyces pombe) >gi|1039340|emb|CAA91237.1|
           (Z64354) replication factor C activator 1 41 kd subunit
           [Schizosaccharomyces pombe]
           Length = 340
           
 Score = 84.3 bits (205), Expect = 3e-15
 Identities = 62/215 (28%), Positives = 105/215 (48%), Gaps = 21/215 (9%)

Query: 4   VPWVEKYRPRRLSEIINQEDAISKVKAWIEAWLHGNPPKKKALLLAGPPGSGKTTTVYAL 63
           +PWVE YRP+ L ++ +QE  +  +K   +  L  N P    +L  G PG+GKT+T+ AL
Sbjct: 19  IPWVELYRPKTLDQVSSQESTVQVLK---KTLLSNNLPH---MLFYGSPGTGKTSTILAL 72

Query: 64  ARE------YNFEVIELNASDER----TYDKIARYVQAAYTMDILG---KRRKIIFLDEA 110
           +RE          V+ELNASDER      +K+  + +   T  + G      KII LDEA
Sbjct: 73  SRELFGPQLMKSRVLELNASDERGISIIREKVKSFAKTTVTNKVDGYPCPPFKIIILDEA 132

Query: 111 DNIEPSGAPEIAKLIDR-AR-NPIIMAANHYWEVPKEIRDRAELVEYKRLTQRDVINALV 168
           D++       + + ++  AR     +  N+   +   +  R     +K L   +++  L 
Sbjct: 133 DSMTQDAQAALRRTMESYARITRFCLICNYMTRIIDPLSSRCSKYRFKPLDNENMVKRLE 192

Query: 169 RILKREGITVPKEVLVEIAKRASGDLRAAINDLQT 203
            I   + +++   V+  + + + GD+R AI  LQ+
Sbjct: 193 FIAADQAVSMEPGVVNALVECSGGDMRKAITFLQS 227


>pir||T39941 hypothetical protein SPBC23E6.07c - fission yeast
           (Schizosaccharomyces pombe) >gi|3116125|emb|CAA18875.1|
           (AL023287) putative activator 1  subunit (replication
           factor) [Schizosaccharomyces pombe]
           Length = 934
           
 Score = 82.3 bits (200), Expect = 1e-14
 Identities = 58/231 (25%), Positives = 102/231 (44%), Gaps = 30/231 (12%)

Query: 2   PEVPWVEKYRPRRLSEIINQEDAISKVKAWIEAWLHGNPPKK------------KALLLA 49
           P   W  KY P  L +I   +  + K++ W++ + H N                KA+LL+
Sbjct: 357 PSQIWTSKYAPTSLKDICGNKGVVQKLQKWLQDY-HKNRKSNFNKPGPDGLGLYKAVLLS 415

Query: 50  GPPGSGKTTTVYALAREYNFEVIELNASDERT-------------YDKIARYVQAAYTMD 96
           GPPG GKTT  + +A+   ++V+ELNASD R+                +A Y        
Sbjct: 416 GPPGIGKTTAAHLVAKLEGYDVLELNASDTRSKRLLDEQLFGVTDSQSLAGYFGTKANPV 475

Query: 97  ILGKRRKIIFLDEADNI---EPSGAPEIAKLIDRARNPIIMAANHYWEVPKEIRDRAEL- 152
            + K R ++ +DE D +   +  G  ++  +I ++  PII   N          DR    
Sbjct: 476 DMAKSRLVLIMDEIDGMSSGDRGGVGQLNMIIKKSMIPIICICNDRAHPKLRPLDRTTFD 535

Query: 153 VEYKRLTQRDVINALVRILKREGITVPKEVLVEIAKRASGDLRAAINDLQT 203
           + ++R     + + ++ I  REG+ +  + + ++ +    D+R  IN L T
Sbjct: 536 LRFRRPDANSMRSRIMSIAYREGLKLSPQAVDQLVQGTQSDMRQIINLLST 586


>gi|6324791 Subunit 1 of Replication Factor C; homologous to human RFC 140 kDa
           subunit; Rfc1p [Saccharomyces cerevisiae]
           >gi|584899|sp|P38630|RFC1_YEAST ACTIVATOR 1 95 KDA
           SUBUNIT (REPLICATION FACTOR C 95 KDA SUBUNIT) (CELL
           DIVISION CONTROL PROTEIN 44) >gi|626116|pir||S44763
           replication factor C chain RFC1 - yeast (Saccharomyces
           cerevisiae) >gi|437274|gb|AAC48916.1| (U03102) Cdc44p
           [Saccharomyces cerevisiae] >gi|841462|gb|AAC49060.1|
           (U26027) Rfc1p [Saccharomyces cerevisiae]
           >gi|1050769|emb|CAA63180.1| (X92441) YOR50-7
           [Saccharomyces cerevisiae] >gi|1420505|emb|CAA99434.1|
           (Z75125) ORF YOR217w [Saccharomyces cerevisiae]
           Length = 861
           
 Score = 81.9 bits (199), Expect = 1e-14
 Identities = 57/227 (25%), Positives = 102/227 (44%), Gaps = 28/227 (12%)

Query: 6   WVEKYRPRRLSEIINQEDAISKVKAWIEAWLHGNPPKKK-----------ALLLAGPPGS 54
           W  KY P  L ++   + ++ K+K W+  W +      K           A +L GPPG 
Sbjct: 298 WTVKYAPTNLQQVCGNKGSVMKLKNWLANWENSKKNSFKHAGKDGSGVFRAAMLYGPPGI 357

Query: 55  GKTTTVYALAREYNFEVIELNASDERTYDKIARYVQAAY-TMDILG------------KR 101
           GKTT  + +A+E  ++++E NASD R+   +   V+ A   M ++G             +
Sbjct: 358 GKTTAAHLVAQELGYDILEQNASDVRSKTLLNAGVKNALDNMSVVGYFKHNEEAQNLNGK 417

Query: 102 RKIIFLDEADNI---EPSGAPEIAKLIDRARNPIIMAANHYWEVPKEIRDRAEL-VEYKR 157
             +I +DE D +   +  G  ++A+   +   P+I+  N          DR  L ++++R
Sbjct: 418 HFVIIMDEVDGMSGGDRGGVGQLAQFCRKTSTPLILICNERNLPKMRPFDRVCLDIQFRR 477

Query: 158 LTQRDVINALVRILKREGITVPKEVLVEIAKRASGDLRAAINDLQTV 204
                + + L+ I  RE   +   V+  + +   GD+R  IN L T+
Sbjct: 478 PDANSIKSRLMTIAIREKFKLDPNVIDRLIQTTRGDIRQVINLLSTI 524


>sp|P35600|GNF1_DROME GERMLINE TRANSCRIPTION FACTOR 1 >gi|304728|gb|AAA28573.1| (L17340)
           transcription factor [Drosophila melanogaster]
           Length = 986
           
 Score = 81.1 bits (197), Expect = 2e-14
 Identities = 69/278 (24%), Positives = 119/278 (41%), Gaps = 41/278 (14%)

Query: 6   WVEKYRPRRLSEIINQEDA---ISKVKAWIEAWLHGNPPKKK-----------------A 45
           WV+K++P  + EI+ Q  A   ++K+  W+  W   +   KK                 A
Sbjct: 423 WVDKHKPTSIKEIVGQAGAASNVTKLMNWLSKWYVNHDGNKKPQRPNPWAKNDDGSFYKA 482

Query: 46  LLLAGPPGSGKTTTVYALAREYNFEVIELNASDERTYDKIARYVQAAYTMDILG------ 99
            LL+GPPG GKTTT   + +E  F+ +E NASD R+   +   V    +   L       
Sbjct: 483 ALLSGPPGIGKTTTATLVVKELGFDAVEFNASDTRSKRLLKDEVSTLLSNKSLSGYFTGQ 542

Query: 100 ----KRRKIIFLDEAD----NIEPSGAPEIAKLIDRARNPIIMAANHYWEVPKEIRDRAE 151
                R+ ++ +DE D    N +  G  E+  LI  +  PII   N     PK IR    
Sbjct: 543 GQAVSRKHVLIMDEVDAMAGNEDRGGMQELIALIKDSSIPIICMCNDR-NHPK-IRSLVN 600

Query: 152 L---VEYKRLTQRDVINALVRILKREGITVPKEVLVEIAKRASGDLRAAINDLQTVVA-- 206
               + ++R     +   ++ I  +E + +    + EI    + D+R +IN +  + A  
Sbjct: 601 YCYDLRFQRPRLEQIKGKIMSICFKEKVKISPAKVEEIIAATNNDIRQSINHIALLSAKE 660

Query: 207 GGYEDARYVLAYRDVEKTVFQALGLVFASDNAKRAKLA 244
              + +   +A +D++   ++ +  VF +D  K    A
Sbjct: 661 DASQKSGQQVATKDLKLGPWEVVRKVFTADEHKHMSFA 698


>gb|AAB58311.1| (U97685) replication factor C large subunit [Drosophila
           melanogaster] >gi|7296805|gb|AAF52082.1| (AE003604) Gnf1
           gene product [Drosophila melanogaster]
           Length = 986
           
 Score = 81.1 bits (197), Expect = 2e-14
 Identities = 69/278 (24%), Positives = 119/278 (41%), Gaps = 41/278 (14%)

Query: 6   WVEKYRPRRLSEIINQEDA---ISKVKAWIEAWLHGNPPKKK-----------------A 45
           WV+K++P  + EI+ Q  A   ++K+  W+  W   +   KK                 A
Sbjct: 423 WVDKHKPTSIKEIVGQAGAASNVTKLMNWLSKWYVNHDGNKKPQRPNPWAKNDDGSFYKA 482

Query: 46  LLLAGPPGSGKTTTVYALAREYNFEVIELNASDERTYDKIARYVQAAYTMDILG------ 99
            LL+GPPG GKTTT   + +E  F+ +E NASD R+   +   V    +   L       
Sbjct: 483 ALLSGPPGIGKTTTATLVVKELGFDAVEFNASDTRSKRLLKDEVSTLLSNKSLSGYFTGQ 542

Query: 100 ----KRRKIIFLDEAD----NIEPSGAPEIAKLIDRARNPIIMAANHYWEVPKEIRDRAE 151
                R+ ++ +DE D    N +  G  E+  LI  +  PII   N     PK IR    
Sbjct: 543 GQAVSRKHVLIMDEVDGMAGNEDRGGMQELIALIKDSSIPIICMCNDR-NHPK-IRSLVN 600

Query: 152 L---VEYKRLTQRDVINALVRILKREGITVPKEVLVEIAKRASGDLRAAINDLQTVVA-- 206
               + ++R     +   ++ I  +E + +    + EI    + D+R +IN +  + A  
Sbjct: 601 YCYDLRFQRPRLEQIKGKIMSICFKEKVKISPAKVEEIIAATNNDIRQSINHIALLSAKE 660

Query: 207 GGYEDARYVLAYRDVEKTVFQALGLVFASDNAKRAKLA 244
              + +   +A +D++   ++ +  VF +D  K    A
Sbjct: 661 DASQKSGQQVATKDLKLGPWEVVRKVFTADEHKHMSFA 698


>pir||T18305 replication factor C like protein - Emericella nidulans
           >gi|1840142|gb|AAB63523.1| (U86619) replication factor C
           like protein [Aspergillus nidulans]
           Length = 1092
           
 Score = 80.8 bits (196), Expect = 3e-14
 Identities = 57/227 (25%), Positives = 100/227 (43%), Gaps = 28/227 (12%)

Query: 6   WVEKYRPRRLSEIINQEDAISKVKAWIEAWLHG------NPPKK-----KALLLAGPPGS 54
           W  KY P  L+ I   + A+ K++AW+  W          P K      +++++ GPPG 
Sbjct: 471 WTSKYAPTSLNMICGNKGAVEKLQAWLRNWRKSAKANFTKPGKDGSGLYRSVMIHGPPGI 530

Query: 55  GKTTTVYALAREYNFEVIELNASDERT-------------YDKIARYVQAAYTMDILGKR 101
           GKTT  + +A+   ++V+E NASD R+                +  Y   +      GK+
Sbjct: 531 GKTTAAHLVAKLEGYDVVESNASDTRSKKLVESGLLGVLDTTSLQGYFSTSNKKVESGKK 590

Query: 102 RKIIFLDEADNI---EPSGAPEIAKLIDRARNPIIMAANHYWEVPKEIRDRAEL-VEYKR 157
             ++ +DE D +   +  G   +A +  + + P+I+  N       +  D     + ++R
Sbjct: 591 NLVLIMDEVDGMSAGDRGGVGAMAAIAKKTQIPLILICNERRLPKMKPFDHVTFEIPFRR 650

Query: 158 LTQRDVINALVRILKREGITVPKEVLVEIAKRASGDLRAAINDLQTV 204
            T   V   L+ I  RE + +P +VL  + +    D+R  IN L  V
Sbjct: 651 PTVEQVRARLLTICFREKMKIPPQVLDSLIEGTHADIRQVINMLSAV 697


>pir||T18306 replication factor C protein - Emericella nidulans
           >gi|2258283|gb|AAB63574.1| (U86620) replication factor C
           like protein [Aspergillus nidulans]
           Length = 1092
           
 Score = 80.8 bits (196), Expect = 3e-14
 Identities = 57/227 (25%), Positives = 100/227 (43%), Gaps = 28/227 (12%)

Query: 6   WVEKYRPRRLSEIINQEDAISKVKAWIEAWLHG------NPPKK-----KALLLAGPPGS 54
           W  KY P  L+ I   + A+ K++AW+  W          P K      +++++ GPPG 
Sbjct: 471 WTSKYAPTSLNMICGNKGAVEKLQAWLRNWRKSAKANFTKPGKDGSGLYRSVMIHGPPGI 530

Query: 55  GKTTTVYALAREYNFEVIELNASDERT-------------YDKIARYVQAAYTMDILGKR 101
           GKTT  + +A+   ++V+E NASD R+                +  Y   +      GK+
Sbjct: 531 GKTTAAHLVAKLEGYDVVESNASDTRSKKLVESGLLGVLDTTSLQGYFSTSNKKVESGKK 590

Query: 102 RKIIFLDEADNI---EPSGAPEIAKLIDRARNPIIMAANHYWEVPKEIRDRAEL-VEYKR 157
             ++ +DE D +   +  G   +A +  + + P+I+  N       +  D     + ++R
Sbjct: 591 NLVLIMDEVDGMSAGDRGGVGAMAAIAKKTQIPLILICNERRLPKMKPFDHVTFEIPFRR 650

Query: 158 LTQRDVINALVRILKREGITVPKEVLVEIAKRASGDLRAAINDLQTV 204
            T   V   L+ I  RE + +P +VL  + +    D+R  IN L  V
Sbjct: 651 PTVEQVRARLLTICFREKMKIPPQVLDSLIEGTHADIRQVINMLSAV 697


>pir||T20230 hypothetical protein C54G10.2 - Caenorhabditis elegans
           >gi|3875243|emb|CAA99812.1| (Z75532) predicted using
           Genefinder~Similarity to Human Replication factor C
           activator 1 140 KD subunit (SW:AC15_HUMAN), contains
           similarity to Pfam domain: PF00004 (ATPases associated
           with various cellular activities (AAA)), Score=-10.6,
           E-value=5.7e->
           Length = 839
           
 Score = 80.8 bits (196), Expect = 3e-14
 Identities = 67/245 (27%), Positives = 113/245 (45%), Gaps = 46/245 (18%)

Query: 2   PEVPWVEKYRPRRLSEIINQ---EDAISKVKAWIEAWLHGN--------PPKK------- 43
           P + WV+KY+P+R+ E++ Q   +  I+K+  WI+ W   N         PK        
Sbjct: 276 PALSWVDKYKPKRMGELVGQNGDKSPINKLLEWIKDWAKHNLGEGAKIKKPKPAPWMSSQ 335

Query: 44  -----KALLLAGPPGSGKTTTVYALAREYNFEVIELNASDERTYD----KIARYVQAAYT 94
                KA LL+G PG GKTT  Y   ++   +++E+NASD R+      KI     +   
Sbjct: 336 DGTSFKAALLSGSPGVGKTTCAYMACQQLGLQLVEMNASDVRSKKHLEAKIGELSGSHQI 395

Query: 95  MDILGKRR----------KIIFLDEAD----NIEPSGAPEIAKLIDRARNPIIMAANHYW 140
               G ++           I+ +DE D    N + +G  E+ ++I  ++ PII   N   
Sbjct: 396 EQFFGAKKCAPQDNQKVHHILIMDEVDGMSGNEDRAGISELIQIIKESKIPIICICNDR- 454

Query: 141 EVPKEIRDRAEL---VEYKRLTQRDVINALVRILKREGITVPKEVLVEIAKRASGDLRAA 197
           + PK IR  A     + + +     + + ++ I  +E + + KE L EI + +  D+R  
Sbjct: 455 QHPK-IRTLANYCYDLRFPKPRVETIRSRMMTICSQEKMKIGKEELDEIIELSGHDVRQT 513

Query: 198 INDLQ 202
           I +LQ
Sbjct: 514 IYNLQ 518


>sp|P53016|AC12_CAEEL PUTATIVE ACTIVATOR 1 37 KD SUBUNIT (REPLICATION FACTOR C 37 KD
           SUBUNIT) (A1 37 KD SUBUNIT) (RF-C 37 KD SUBUNIT) (RFC37)
           >gi|7444554|pir||T16219 hypothetical protein F31E3.3 -
           Caenorhabditis elegans >gi|1072162|gb|AAA81689.1|
           (U40935) similar to replication factor C 37 kda subunit
           (human) and F44B9.8 [Caenorhabditis elegans]
           Length = 334
           
 Score = 80.0 bits (194), Expect = 5e-14
 Identities = 60/227 (26%), Positives = 107/227 (46%), Gaps = 27/227 (11%)

Query: 6   WVEKYRPRRLSEIINQEDAISKVKAWIEAWLHGNPPKKKALLLAGPPGSGKTTTVYALAR 65
           W EKYRP+ L +I  Q++ ++ +K  ++            LL  GPPG+GKT+   A  R
Sbjct: 17  WTEKYRPKTLDDIAYQDEVVTMLKGALQG------RDLPHLLFYGPPGTGKTSAALAFCR 70

Query: 66  E------YNFEVIELNASDERTYDKIARYVQA--------AYTMDILGKRRKIIFLDEAD 111
           +      ++  V++LNASDER    + + +Q+        ++  D+L  + KII LDE D
Sbjct: 71  QLFPKNIFHDRVLDLNASDERGIAVVRQKIQSFSKSSLGHSHREDVL--KLKIIILDEVD 128

Query: 112 NIEPSGAPEIAKLID--RARNPIIMAANHYWEVPKEIRDRAELVEYKRLTQRDVINALVR 169
            +       + ++I+        I+  N+   +   +  R     +K L     +  L  
Sbjct: 129 AMTREAQAAMRRVIEDFSKTTRFILICNYVSRLIPPVVSRCAKFRFKSLPAEIQVQRLRT 188

Query: 170 ILKREGITVPKEVLVEIAKRASGDLRAAINDLQT---VVAGGYEDAR 213
           I   EG  +  + L ++ + + GDLR A+  LQ+   ++  G ++AR
Sbjct: 189 ICDAEGTPMSDDELKQVMEYSEGDLRRAVCTLQSLAPILKSGDDNAR 235


>sp|P34429|AC11_CAEEL PUTATIVE ACTIVATOR 1 36 KD SUBUNIT (REPLICATION FACTOR C 36 KD
           SUBUNIT) (A1 36 KD SUBUNIT) (RF-C 36 KD SUBUNIT) (RFC36)
           >gi|630627|pir||S44809 F44B9.8 protein - Caenorhabditis
           elegans >gi|388588|gb|AAA28028.1| (L23648) homology with
           A1 replicative polymerase accessory protein; putative
           [Caenorhabditis elegans]
           Length = 447
           
 Score = 80.0 bits (194), Expect = 5e-14
 Identities = 80/269 (29%), Positives = 120/269 (43%), Gaps = 58/269 (21%)

Query: 4   VPWVEKYRPRRLSEIINQEDAISKVKAWIEAWLHGNPPKKKALLLAGPPGSGKTTTVYAL 63
           +PWVEKYRP +L E++  E     VK +I             LL  GPPG+GKTTTV A 
Sbjct: 29  LPWVEKYRPSKLDELVAHEQI---VKTYILVTKFIENRTLPHLLFYGPPGTGKTTTVLAA 85

Query: 64  AREYNFE------VIELNASDERTYDKI---------ARYVQAAYTMDILGK-RRKIIFL 107
           AR+          V+ELNASDER  D +          + +QA  T    G    K++ L
Sbjct: 86  ARQMYSPTKMASMVLELNASDERGIDVVRNTIVNFAQTKGLQAFSTSSNTGTVPFKLVIL 145

Query: 108 DEADNIEPSGAPEIAKL--IDRARNPIIMAANHYWEVPKE-------------------- 145
           DEAD +       + +L   D  +N II   N Y+ V ++                    
Sbjct: 146 DEADAMTKDAQNALRRLDKTDYEQNIIIHNVNIYFRVIEKYTDNVRFCIICNYLASIVPA 205

Query: 146 IRDRAELVEYKRLTQRDVINALVRILKREGITVP---KEVLVEIAKRASGDLRAAINDLQ 202
           I+ R     +  L Q+ ++  L  I++ E + +    K+ L+ ++K   GD+R  IN LQ
Sbjct: 206 IQSRCTRFRFAPLDQKLIVPRLEYIVETEQLKMTPDGKDALLIVSK---GDMRTVINTLQ 262

Query: 203 TVVAGGYEDARYVLAYRDV-EKTVFQALG 230
           +            +++  V E TV+Q +G
Sbjct: 263 ST----------AMSFDTVSENTVYQCIG 281


>pir||T50383 homolog to yeast chl12 protein [imported] - fission yeast
           (Schizosaccharomyces pombe) >gi|6522992|emb|CAB62096.1|
           (AL133306) similar to S. cerevisiae chl12 protein
           [Schizosaccharomyces pombe]
           Length = 960
           
 Score = 79.6 bits (193), Expect = 7e-14
 Identities = 58/246 (23%), Positives = 103/246 (41%), Gaps = 49/246 (19%)

Query: 6   WVEKYRPRRLSEIINQEDAISKVKAWIEAW---------------LHGNP---------- 40
           WV+ YRP+   +++  E        WI+AW               +  NP          
Sbjct: 353 WVDTYRPQLFRDLLGDERVHRAAMHWIKAWDPCVFGKSRLQPSKSMRFNPRFTNITSDSD 412

Query: 41  -PKKKALLLAGPPGSGKTTTVYALAREYNFEVIELNASDERTYDKIARYVQAAYT-MDIL 98
            P K+ ++L G  G+GKTT  + +A +  ++V+E+NASD+RT   +   V +A +    L
Sbjct: 413 RPDKRIMMLTGLAGAGKTTLAHVIAHQAGYKVLEINASDDRTAHTVHEKVSSAISNHSAL 472

Query: 99  GKRRKIIFLDEADNIEPSGAPEIAKLID---------------------RARNPIIMAAN 137
             +   + +DE D  +P+    +  L++                     +   PII   N
Sbjct: 473 SSQPTCVIVDEIDGGDPAFVRALLSLLESDEKATEYSQAGNSKKKKKFKKLCRPIICICN 532

Query: 138 H-YWEVPKEIRDRAELVEYKRLTQRDVINALVRILKREGITVPKEVLVEIAKRASGDLRA 196
             Y    + +R  A+++ ++   Q  ++  L  I + E I V    L  +    + D+R+
Sbjct: 533 DLYTPALRPLRPYAQIIYFRPPPQASLVGRLRTICRNENIAVDSRSLTLLTDIYNSDIRS 592

Query: 197 AINDLQ 202
            IN LQ
Sbjct: 593 CINSLQ 598


>emb|CAB92098.1| (AL356333) Replication factor C 36 KD subunit; activator 1 36 kd
           subunit [Schizosaccharomyces pombe]
           Length = 142
           
 Score = 79.2 bits (192), Expect = 9e-14
 Identities = 44/114 (38%), Positives = 68/114 (59%), Gaps = 12/114 (10%)

Query: 4   VPWVEKYRPRRLSEIINQEDAISKVKAWIEAWLHGNPPKKKALLLAGPPGSGKTTTVYAL 63
           +PWVEKYRP  L ++++ +D IS ++ +I +       +   +L  GPPG+GKT+T+ A 
Sbjct: 23  LPWVEKYRPANLEDVVSHKDIISTLEKFISS------NRVPHMLFYGPPGTGKTSTILAC 76

Query: 64  ARE-----YNFEVIELNASDERTYDKIARYVQ-AAYTMDILGKRRKIIFLDEAD 111
           AR+     Y  +++ELNASD+R  D +   ++  A T  I     K+I LDEAD
Sbjct: 77  ARKIYGPNYRNQLMELNASDDRGIDAVREQIKNFASTRQIFASTFKMIILDEAD 130


>gb|AAG21804.1|AF210454_2 (AF210454) replication factor C subunit 1 [Ectocarpus siliculosus
           virus]
           Length = 324
           
 Score = 74.9 bits (181), Expect = 2e-12
 Identities = 56/222 (25%), Positives = 101/222 (45%), Gaps = 24/222 (10%)

Query: 1   MPEVPWVEKYRPRRLSEIINQEDAISKVKAWIEAWLHGNPPKKKA----LLLAGPPGSGK 56
           M   PWVEKYRP   SE++  + +IS         L  N   K+     LL+ GP G GK
Sbjct: 1   MTAQPWVEKYRPLCFSEVVGNKKSIS---------LLSNLAAKRVSIPHLLICGPSGCGK 51

Query: 57  TTTVYALA-----REYNFEVIELNASDERTYDK----IARYVQAAYTMDILGKRRKIIFL 107
           T  V  L            ++ L++ DER  D     +  + +     +      KI+ L
Sbjct: 52  TVCVDILCNTMIPENRGARMLRLSSFDERGIDNVRTTVKNFARGRVGTEPTPTIAKIVVL 111

Query: 108 DEADNIEPSGAPEIAKLID--RARNPIIMAANHYWEVPKEIRDRAELVEYKRLTQRDVIN 165
           DEAD++ P     + +++D   +    I+  N+  ++ + I+ R  ++ + ++    +  
Sbjct: 112 DEADSMTPGAFQALRRIMDVYSSTTRFIIVCNNSTKIIEPIQSRCAILRFSKVDDAQLRL 171

Query: 166 ALVRILKREGITVPKEVLVEIAKRASGDLRAAINDLQTVVAG 207
            + ++    G+      +  +A  A GD+R+AIN L ++V+G
Sbjct: 172 RIRQVCDMAGVEYDPGGIGALACVADGDVRSAINSLASIVSG 213


>gb|AAF48768.1| (AE003506) CG8142 gene product [Drosophila melanogaster]
           Length = 288
           
 Score = 74.1 bits (179), Expect = 3e-12
 Identities = 50/173 (28%), Positives = 84/173 (47%), Gaps = 15/173 (8%)

Query: 46  LLLAGPPGSGKTTTVYALARE-----YNFEVIELNASDERTYDKIARYVQAAYTMDILGK 100
           +LL GPPG+GKT+T+ A +R+     +   ++ELNASDER  + +   ++    +     
Sbjct: 1   MLLYGPPGTGKTSTILAASRQIFGDMFKDRILELNASDERGINVVRTKIKNFSQLSASSV 60

Query: 101 RR--------KIIFLDEADNIEPSGAPEIAKLIDRARNP--IIMAANHYWEVPKEIRDRA 150
           R         KII LDEAD++  +    + + +++        +  N+   +   I  R 
Sbjct: 61  RPDGKPCPPFKIIILDEADSMTHAAQSALRRTMEKESRSTRFCLICNYVSRIIVPITSRC 120

Query: 151 ELVEYKRLTQRDVINALVRILKREGITVPKEVLVEIAKRASGDLRAAINDLQT 203
               +K L +  VI+ L  I + EG+ +  +    I K + GDLR AI  LQ+
Sbjct: 121 SKFRFKALGEDKVIDRLKYICEMEGVKIEDDAYKSIVKISGGDLRRAITTLQS 173


>dbj|BAB03292.1| (AB037375) replication factor C small subunit precursor [Pyrococcus
           furiosus]
           Length = 268
           
 Score = 73.4 bits (177), Expect = 5e-12
 Identities = 53/158 (33%), Positives = 80/158 (50%), Gaps = 8/158 (5%)

Query: 57  TTTVYALARE-----YNFEVIELNASDERTYDKIARYVQA-AYTMDILGKRRKIIFLDEA 110
           TT   ALARE     +    +ELNASDER  + I   V+  A T  I G   KIIFLDEA
Sbjct: 1   TTAALALARELFGENWRHNFLELNASDERGINVIREKVKEFARTKPIGGASFKIIFLDEA 60

Query: 111 DNIEPSGAPEIAKLIDRARNPI--IMAANHYWEVPKEIRDRAELVEYKRLTQRDVINALV 168
           D +       + + ++   + +  I++ N+  ++ + I+ R  +  ++ L   D+   L 
Sbjct: 61  DALTQDAQQALRRTMEMFSSNVRFILSCNYSSKIIEPIQSRCAIFRFRPLRDEDIAKRLR 120

Query: 169 RILKREGITVPKEVLVEIAKRASGDLRAAINDLQTVVA 206
            I + EG+ + +E L  I   A GD+R AIN LQ   A
Sbjct: 121 YIAENEGLELTEEGLQAILYIAEGDMRRAINILQAAAA 158


>pir||F71231 probable replication factor C subunit - Pyrococcus horikoshii
           >gi|3256498|dbj|BAA29181.1| (AP000001) 855aa long
           hypothetical replication factor C subunit [Pyrococcus
           horikoshii]
           Length = 855
           
 Score = 72.2 bits (174), Expect = 1e-11
 Identities = 52/158 (32%), Positives = 80/158 (49%), Gaps = 8/158 (5%)

Query: 57  TTTVYALARE-----YNFEVIELNASDERTYDKIARYVQA-AYTMDILGKRRKIIFLDEA 110
           TT   AL+RE     +    +ELNASDER  + I   V+  A T  I G   KIIFLDEA
Sbjct: 587 TTAALALSRELFGENWRHNFLELNASDERGINVIREKVKEFARTKPIGGASFKIIFLDEA 646

Query: 111 DNIEPSGAPEIAKLIDRARNPI--IMAANHYWEVPKEIRDRAELVEYKRLTQRDVINALV 168
           D +       + + ++   + +  I++ N+  ++ + I+ R  +  ++ L   D+   L 
Sbjct: 647 DALTQDAQQALRRTMEMFSSNVRFILSCNYSSKIIEPIQSRCAIFRFRPLRDEDIAKRLR 706

Query: 169 RILKREGITVPKEVLVEIAKRASGDLRAAINDLQTVVA 206
            I + EG+ + +E L  I   A GD+R AIN LQ   A
Sbjct: 707 YIAENEGLELTEEGLQAILYIAEGDMRRAINILQAAAA 744


>gb|AAF52944.1| (AE003628) RfC3 gene product [Drosophila melanogaster]
           Length = 297
           
 Score = 71.4 bits (172), Expect = 2e-11
 Identities = 48/174 (27%), Positives = 88/174 (49%), Gaps = 9/174 (5%)

Query: 41  PKKKALLLAGPPGSGKTTTVYALAR------EYNFEVIELNASDERTYDKI-ARYVQAAY 93
           P    LL  GPPG+GKT+T+ A AR      ++   V+ELNASD+R    +  + +  A 
Sbjct: 7   PALPHLLFYGPPGTGKTSTILACARQLYSPQQFKSMVLELNASDDRGIGIVRGQILNFAS 66

Query: 94  TMDILGKRRKIIFLDEADNIEPSGAPEIAKLIDRARNPI--IMAANHYWEVPKEIRDRAE 151
           T  I     K+I LDEAD +       + ++I++  + +   +  N+  ++   ++ R  
Sbjct: 67  TRTIFCDTFKLIILDEADAMTNDAQNALRRIIEKYTDNVRFCVICNYLSKIIPALQSRCT 126

Query: 152 LVEYKRLTQRDVINALVRILKREGITVPKEVLVEIAKRASGDLRAAINDLQTVV 205
              +  L+Q  ++  L +I++ E + + ++    +   A GD+R  +N LQ+ V
Sbjct: 127 RFRFAPLSQDQMMPRLEKIIEAEAVQITEDGKRALLTLAKGDMRKVLNVLQSTV 180


>emb|CAB93386.1| (AL357523) conserved ATP/GTP binding protein [Streptomyces
           coelicolor A3(2)]
           Length = 451
           
 Score = 71.0 bits (171), Expect = 3e-11
 Identities = 59/234 (25%), Positives = 103/234 (43%), Gaps = 12/234 (5%)

Query: 5   PWVEKYRPRRLSEIINQEDAI---SKVKAWIEAWLHGNPPKKKALLLAGPPGSGKTTTVY 61
           P   + RPR L E++ Q+  +   S ++  +     G P    +++L GPPG+GKTT  Y
Sbjct: 22  PLAVRMRPRTLDEVVGQQHLLKPGSPLRRLVGEGASG-PAGPSSVILWGPPGTGKTTLAY 80

Query: 62  ALAREYNFEVIELNASDERTYDKIARYVQAAYTMDILGKRRKIIFLDEADNIEPSGAPEI 121
            +++  N   +EL+A      +  A    A   +   GK   ++FLDE      +    +
Sbjct: 81  VVSKATNKRFVELSAITAGVKEVRAVIDGARRAVGGYGK-ETVLFLDEIHRFSKAQQDSL 139

Query: 122 AKLIDRARNPIIMAA--NHYWEVPKEIRDRAELVEYKRLTQRDVINALVRILKRE----- 174
              ++     +I A   N Y+ V   +  R+ L+  + LT  DV + L R L  E     
Sbjct: 140 LPAVENRWVTLIAATTENPYFSVISPLLSRSLLLTLEPLTDDDVRDLLRRALTDERGLKG 199

Query: 175 GITVPKEVLVEIAKRASGDLRAAINDLQTVVAGGYEDARYVLAYRDVEKTVFQA 228
            +T+P +    + + A GD R A+  L+       +     +    +E+TV +A
Sbjct: 200 AVTLPGDTEEHLLRIAGGDARRALTALEAAAGAALDKGEAEVGLTTLEETVDRA 253


>pir||C75339 conserved hypothetical protein - Deinococcus radiodurans  (strain
           R1) >gi|6459682|gb|AAF11452.1|AE002029_1 (AE002029)
           conserved hypothetical protein [Deinococcus radiodurans]
           Length = 434
           
 Score = 69.5 bits (167), Expect = 8e-11
 Identities = 65/235 (27%), Positives = 96/235 (40%), Gaps = 20/235 (8%)

Query: 2   PEVPWVEKYRPRRLSEIINQEDAISKVKAWIEAWLHGNPPKKKALLLAGPPGSGKTTTVY 61
           P  P  E+ RPR ++E+  Q   +   K        G   +  +L+L GPPG GKTT   
Sbjct: 6   PPAPLAERLRPRTVAEVAGQSHLLGAGKPLTRVLQSG---RLGSLILWGPPGVGKTTLAR 62

Query: 62  ALAREYNFEVIELNASDERTYDKIARYVQAAYTMDILGKRRKIIFLDEADNIEPSGAPEI 121
            LA E     I L+A      D   R   A    +    RR ++FLDE      +    +
Sbjct: 63  LLAGEVGAHFIALSAVSAGVKD--VRDAVAEAEREQARGRRTVLFLDEIHRFNKAQQDAL 120

Query: 122 AKLIDRARNPIIMAA--NHYWEVPKEIRDRAELVEYKRLTQRDVINALVRILKRE----G 175
              ++     +I A   N  +EV   +R RA  +  + L+  DV+  L R L  E    G
Sbjct: 121 LPHVESGLLTLIGATTENPSFEVNPALRSRARTLVLEALSPEDVLALLRRALSDERGLPG 180

Query: 176 ITVPKEVLVEIAKRASGDLRAAINDLQTVVAGGYEDARYVLAYRDVEKTVFQALG 230
           +      L  +A+ A GD R A++ L+             LA    E+ V +A G
Sbjct: 181 VEAEDSALELLARLAEGDARRALSTLEVAA---------TLANPVTEEAVTEAFG 226


  Database: ./suso.pep
    Posted date:  Jul 6, 2001  5:57 PM
  Number of letters in database: 840,471
  Number of sequences in database:  2977
  
  Database: /banques/blast2/nr.pep
    Posted date:  Dec 14, 2000 12:46 PM
  Number of letters in database: 188,266,275
  Number of sequences in database:  595,510
  
Lambda     K      H
   0.315    0.133    0.369 

Gapped
Lambda     K      H
   0.270   0.0470    0.230 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 172519391
Number of Sequences: 2977
Number of extensions: 7584890
Number of successful extensions: 219230
Number of sequences better than 1.0e-10: 73
Number of HSP's better than  0.0 without gapping: 7
Number of HSP's successfully gapped in prelim test: 66
Number of HSP's that attempted gapping in prelim test: 218680
Number of HSP's gapped (non-prelim): 176
length of query: 479
length of database: 189,106,746
effective HSP length: 61
effective length of query: 418
effective length of database: 152,599,039
effective search space: 63786398302
effective search space used: 63786398302
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 41 (21.6 bits)
S2: 167 (69.5 bits)