BLASTP 2.0.10 [Aug-26-1999]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= PAB0087 (pbp) DE:related BETA-LACTAMASE PRECURSOR (EC 3.5.2.6)
(PENICILLIN-BINDING PROTEIN)
(447 letters)
Database: ./suso.pep; /banques/blast2/nr.pep
598,487 sequences; 189,106,746 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
pir||G75201 probable beta-lactamase (EC 3.5.2.6) PAB0087 - Pyroc... 906 0.0
pir||D71235 hypothetical protein PH0142 - Pyrococcus horikoshii ... 506 e-142
pir||A72725 probable beta-lactamase APE0338 - Aeropyrum pernix (... 330 2e-89
pir||E71235 hypothetical protein PH0143 - Pyrococcus horikoshii ... 245 6e-64
gb|AAF86053.1|AF210139_1 (AF210139) fmtA-like protein [Staphyloc... 142 9e-33
sp|P32959|PBPE_BACSU PENICILLIN-BINDING PROTEIN 4* (PBP 4*) (PBP... 125 1e-27
emb|CAB08016.1| (Z94043) penicillin-binding protein [Bacillus su... 125 1e-27
dbj|BAB04434.1| (AP001509) unknown conserved protein [Bacillus h... 125 1e-27
pir||E70687 hypothetical protein Rv1730c - Mycobacterium tubercu... 122 6e-27
dbj|BAB05986.1| (AP001515) penicillin-binding protein [Bacillus ... 120 4e-26
pir||E82658 beta-lactamase XF1621 [imported] - Xylella fastidios... 118 1e-25
pir||S75832 penicillin-binding protein 4 - Synechocystis sp. (st... 113 6e-24
pir||C69673 penicillin-binding protein pbpX - Bacillus subtilis ... 109 6e-23
dbj|BAA13079.1| (D86380) Alkaline D-peptidase [Bacillus cereus] 108 2e-22
pir||T35155 hypothetical protein SC5A7.06c SC5A7.06c - Streptomy... 107 2e-22
pir||F70634 hypothetical protein Rv1922 - Mycobacterium tubercul... 104 2e-21
emb|CAA09676.1| (AJ011526) D-stereospecific peptide hydrolase [B... 104 3e-21
gb|AAD28043.1|AF124203_1 (AF124203) beta-lactamase precursor [Es... 102 1e-20
gb|AAD28041.1|AF124201_1 (AF124201) beta-lactamase precursor [Es... 101 1e-20
pir||S08296 beta-lactamase (EC 3.5.2.6) precursor - Citrobacter ... 100 3e-20
pir||T19869 hypothetical protein C40H5.4 - Caenorhabditis elegan... 100 4e-20
pir||S44094 beta-lactamase (EC 3.5.2.6) - Citrobacter freundii >... 100 5e-20
pir||T36599 probable beta-lactamase - Streptomyces coelicolor >g... 100 5e-20
dbj|BAA02494.1| (D13207) beta-lactamase precursor [Citrobacter f... 99 7e-20
emb|CAA75401.1| (Y15129) beta lactamase class C [Citrobacter fre... 99 7e-20
dbj|BAA32077.1| (AB016611) ampC [Enterobacter cloacae] 99 9e-20
gb|AAD28042.1|AF124202_1 (AF124202) beta-lactamase precursor [Es... 99 9e-20
sp|P05193|AMPC_CITFR BETA-LACTAMASE PRECURSOR (CEPHALOSPORINASE)... 99 9e-20
emb|CAB36902.1| (AJ011293) beta-lactamase [Escherichia coli] 98 2e-19
emb|CAA65752.1| (X97039) LAT-2 b-lactamase [Klebsiella pneumonia... 98 2e-19
emb|CAB36900.1| (AJ011291) beta-lactamase [Escherichia coli] 98 2e-19
emb|CAC08446.1| (AJ278995) class C beta-lactamase [Enterobacter ... 98 2e-19
gb|AAD22636.1| (M37839) beta-lactamase [Klebsiella pneumoniae] 98 3e-19
pir||S45109 beta-lactamase (EC 3.5.2.6) precursor - Klebsiella p... 97 4e-19
emb|CAA62957.1| (X91840) extended spectrum beta-lactamase [Klebs... 97 4e-19
gb|AAB80855.1| (U77414) bla LAT-3 [Salmonella senftenberg] 97 4e-19
emb|CAA75402.1| (Y15130) beta-lactamase class C [Proteus mirabil... 97 4e-19
emb|CAA75610.1| (Y15411) beta-lactamase LAT-3 protein [Escherich... 97 4e-19
pdb|1C3B|A Chain A, Ampc Beta-Lactamase From E. Coli Complexed W... 97 4e-19
sp|P00811|AMPC_ECOLI BETA-LACTAMASE PRECURSOR (CEPHALOSPORINASE)... 97 4e-19
dbj|BAA12916.1| (D85910) beta-lactamase [Citrobacter freundii] 97 5e-19
dbj|BAA94704.1| (AB026907) D-Amino acid amidase [Ochrobactrum an... 97 5e-19
emb|CAA75611.1| (Y15412) beta-lactamase LAT-4 protein [Escherich... 96 6e-19
emb|CAC08444.1| (AJ278994) class C beta-lactamase [Enterobacter ... 96 6e-19
emb|CAA30879.1| (X08082) beta-lactamase precursor [Enterobacter ... 96 6e-19
pir||PNKBM beta-lactamase (EC 3.5.2.6) precursor - Enterobacter ... 96 6e-19
gb|AAC45086.2| (U58495) beta-lactamase ACT-1 [Klebsiella pneumon... 96 6e-19
dbj|BAA07922.1| (D44479) class C beta-lactamase precursor [Enter... 96 8e-19
pdb|1GCE|A Chain A, Structure Of The Beta-Lactamase Of Enterobac... 96 8e-19
pir||A83422 hypothetical protein PA1797 [imported] - Pseudomonas... 96 1e-18
emb|CAB50867.1| (Y17716) beta-lactamase CMY-5 [Klebsiella oxytoca] 96 1e-18
emb|CAA76382.1| (Y16785) beta-lactamase class C [Proteus mirabilis] 96 1e-18
pir||PNKBQ beta-lactamase (EC 3.5.2.6) precursor - Enterobacter ... 95 1e-18
pir||S39196 beta-lactamase (EC 3.5.2.6) - Escherichia coli >gi|4... 95 1e-18
emb|CAA06639.1| (AJ005633) AmpC-type beta-lactamase [Enterobacte... 95 2e-18
sp|Q06317|PBP4_NOCLA PENICILLIN-BINDING PROTEIN 4 (PBP-4) >gi|48... 94 3e-18
emb|CAC16709.1| (AL450289) putative hydrolase [Streptomyces coel... 94 3e-18
gb|AAF18992.1|AF211348_1 (AF211348) beta-lactamase AmpC [Enterob... 94 4e-18
gb|AAD12161.1| (AF055922) dipeptidil carboxypeptidase [Streptomy... 94 4e-18
emb|CAB37344.2| (AJ009971) hypothetical protein [Streptomyces fr... 94 4e-18
pdb|2BLT|A Chain A, Beta-Lactamase (E.C.3.5.2.6) (Cephalosporina... 93 5e-18
sp|P05364|AMPC_ENTCL BETA-LACTAMASE PRECURSOR (CEPHALOSPORINASE)... 93 5e-18
sp|P94958|AMPC_MORMO BETA-LACTAMASE PRECURSOR (CEPHALOSPORINASE)... 92 1e-17
gb|AAG36927.1|AF259520_4 (AF259520) cephalosporinase DHA-2 [Kleb... 92 2e-17
pir||T35438 probable secreted peptidase - Streptomyces coelicolo... 91 3e-17
emb|CAA76196.1| (Y16410) beta-lactamase class C [Salmonella ente... 89 8e-17
gb|AAF26905.1|AF210843_2 (AF210843) unknown [Sorangium cellulosum] 89 1e-16
pir||T26938 hypothetical protein Y45F10D.11 - Caenorhabditis ele... 89 1e-16
gb|AAF59826.1| (U33634) esterase EstB [Pseudomonas marginata] 84 3e-15
gb|AAF86698.1|AF180959_1 (AF180959) AMPC cephalosporinase precur... 84 3e-15
emb|CAC17625.1| (AJ295343) beta-lactamase class C [Ochrobactrum ... 84 3e-15
sp|P15555|DAC_STRSQ D-ALANYL-D-ALANINE CARBOXYPEPTIDASE PRECURSO... 83 6e-15
pdb|3PTE| D-Alanyl-D-Alanine CarboxypeptidaseTRANSPEPTIDASE (E... 83 6e-15
emb|CAC17624.1| (AJ295342) beta-lactamase class C [Ochrobactrum ... 83 8e-15
pir||T36443 probable penicillin-binding protein - Streptomyces c... 82 1e-14
emb|CAC17623.1| (AJ295341) beta-lactamase class C [Ochrobactrum ... 82 1e-14
emb|CAB46491.1| (AJ133121) AmpC beta-lactamase ACC-1 [Klebsiella... 82 2e-14
gb|AAF86692.1|AF180953_1 (AF180953) AMPC cephalosporinase precur... 82 2e-14
sp|Q11037|YD67_MYCTU HYPOTHETICAL 41.3 KDA PROTEIN RV1367C >gi|7... 82 2e-14
pir||G71680 penicillin-binding protein 4 (pbpE) RP259 - Ricketts... 82 2e-14
emb|CAC17626.1| (AJ295344) beta-lactamase class C [Ochrobactrum ... 81 3e-14
emb|CAC17627.1| (AJ295345) beta-lactamase class C [Ochrobactrum ... 81 3e-14
gb|AAF86694.1|AF180955_1 (AF180955) AMPC cephalosporinase precur... 80 4e-14
emb|CAC04522.1| (AJ401618) AmpC beta-lactamase class C [Ochrobac... 80 5e-14
pir||A42209 D-stereospecific aminopeptidase (EC 3.4.11.19) - Och... 80 5e-14
pir||S00765 serine-type D-Ala-D-Ala carboxypeptidase (EC 3.4.16.... 80 7e-14
gb|AAF86695.1|AF180956_1 (AF180956) AMPC cephalosporinase precur... 79 1e-13
gb|AAF86700.1|AF180961_1 (AF180961) AMPC cephalosporinase precur... 78 2e-13
dbj|BAB16316.1| (AB049588) class C beta-lactamase [Escherichia c... 78 2e-13
gb|AAF86696.1|AF180957_1 (AF180957) AMPC cephalosporinase precur... 78 2e-13
gb|AAF86691.1|AF180952_3 (AF180952) AMPC cephalosporinase ACC-2 ... 78 2e-13
gb|AAD50818.2|AF167990_1 (AF167990) AmpC-type class C beta-lacta... 78 2e-13
emb|CAC17149.1| (AJ299421) cephalosporinase [Ochrobactrum anthropi] 78 3e-13
emb|CAC17622.1| (AJ295340) beta-lactamase class C [Ochrobactrum ... 77 3e-13
dbj|BAA23130.1| (AB008454) SRT-1 [Serratia marcescens] 77 3e-13
emb|CAA63264.1| (X92508) ES-beta-lactamase [Klebsiella pneumoniae] 77 3e-13
pir||S41941 beta-lactamase, class C - Klebsiella pneumoniae >gi|... 77 4e-13
emb|CAA71325.1| (Y10282) ES-beta-lactamase [Escherichia coli] 76 1e-12
sp|P45460|AMPC_YEREN BETA-LACTAMASE PRECURSOR (CEPHALOSPORINASE)... 75 1e-12
gb|AAG12974.1| (AY007369) beta-lactamase FOX-5 [Klebsiella pneum... 75 1e-12
emb|CAA71947.1| (Y11068) beta-lactamase class C [Klebsiella oxyt... 75 2e-12
emb|CAB94057.1| (AL358672) putative secreted protein. [Streptomy... 75 2e-12
dbj|BAA23131.1| (AB008455) SST-1 [Serratia marcescens] 75 2e-12
pir||S76446 hypothetical protein - Synechocystis sp. (strain PCC... 75 2e-12
emb|CAB82578.1| (AJ276453) beta-lactamase [Klebsiella pneumoniae] 75 2e-12
sp|O69773|AMPC_PROST BETA-LACTAMASE PRECURSOR (CEPHALOSPORINASE)... 74 3e-12
emb|CAB69829.1| (AJ271368) class C beta-lactamase [Serratia marc... 74 4e-12
emb|CAB89086.1| (AJ277535) beta-lactamase class C [Escherichia c... 74 4e-12
emb|CAB77444.1| (AJ009979) beta-lactamase class C [Acinetobacter... 71 2e-11
pir||E65017 hypothetical protein b2430 - Escherichia coli (strai... 71 3e-11
sp|P77619|YFEW_ECOLI HYPOTHETICAL 47.8 KDA PROTEIN IN UCPA-AMIA ... 71 3e-11
>pir||G75201 probable beta-lactamase (EC 3.5.2.6) PAB0087 - Pyrococcus abyssi
(strain Orsay) >gi|5457571|emb|CAB49062.1| (AJ248283)
related BETA-LACTAMASE PRECURSOR (EC 3.5.2.6)
(PENICILLIN-BINDING PROTEIN) [Pyrococcus abyssi]
Length = 447
Score = 906 bits (2317), Expect = 0.0
Identities = 447/447 (100%), Positives = 447/447 (100%)
Query: 1 MDVGKLESFIVEKMAERKVPGISISIIKDGDVVYAKGFGYRNVEARLPSTPETIYGIGSI 60
MDVGKLESFIVEKMAERKVPGISISIIKDGDVVYAKGFGYRNVEARLPSTPETIYGIGSI
Sbjct: 1 MDVGKLESFIVEKMAERKVPGISISIIKDGDVVYAKGFGYRNVEARLPSTPETIYGIGSI 60
Query: 61 TKSFTALAIMKLVEEGGLSLDDPVEKFVNIKLRPFGEPVTVHHLLTHSSGIPSLGYAEAF 120
TKSFTALAIMKLVEEGGLSLDDPVEKFVNIKLRPFGEPVTVHHLLTHSSGIPSLGYAEAF
Sbjct: 61 TKSFTALAIMKLVEEGGLSLDDPVEKFVNIKLRPFGEPVTVHHLLTHSSGIPSLGYAEAF 120
Query: 121 IDGMVGGDNWLPVSTPEETIAFARDMEKWAVAKPGERFFYLNTGYVLLGKIIEKVSGVSY 180
IDGMVGGDNWLPVSTPEETIAFARDMEKWAVAKPGERFFYLNTGYVLLGKIIEKVSGVSY
Sbjct: 121 IDGMVGGDNWLPVSTPEETIAFARDMEKWAVAKPGERFFYLNTGYVLLGKIIEKVSGVSY 180
Query: 181 EEYIKKKILEPLGMNRSYFFKEEVEKDKDVAMGYILDKEGRLVPQPFPYGITADGGLLSS 240
EEYIKKKILEPLGMNRSYFFKEEVEKDKDVAMGYILDKEGRLVPQPFPYGITADGGLLSS
Sbjct: 181 EEYIKKKILEPLGMNRSYFFKEEVEKDKDVAMGYILDKEGRLVPQPFPYGITADGGLLSS 240
Query: 241 VLDLAKYLKMYIERDESIVSKEYIEKMETSYIKVPWEIFGGEGYGYGLIIYPNFLGEKLV 300
VLDLAKYLKMYIERDESIVSKEYIEKMETSYIKVPWEIFGGEGYGYGLIIYPNFLGEKLV
Sbjct: 241 VLDLAKYLKMYIERDESIVSKEYIEKMETSYIKVPWEIFGGEGYGYGLIIYPNFLGEKLV 300
Query: 301 GHSGSVGMYTGYIGYIPEKKIGVAVLENSSGYPPSYIAMYALALLLGKNPEKELPFIYRE 360
GHSGSVGMYTGYIGYIPEKKIGVAVLENSSGYPPSYIAMYALALLLGKNPEKELPFIYRE
Sbjct: 301 GHSGSVGMYTGYIGYIPEKKIGVAVLENSSGYPPSYIAMYALALLLGKNPEKELPFIYRE 360
Query: 361 RILKKVEGRYMGYKGTIKFEVKVDGDVVYLRALGRAFTYTIPLFPEVLEEDFIKCYTLSN 420
RILKKVEGRYMGYKGTIKFEVKVDGDVVYLRALGRAFTYTIPLFPEVLEEDFIKCYTLSN
Sbjct: 361 RILKKVEGRYMGYKGTIKFEVKVDGDVVYLRALGRAFTYTIPLFPEVLEEDFIKCYTLSN 420
Query: 421 GRKMYAEFYIKDNKVDLIFERYRLIKS 447
GRKMYAEFYIKDNKVDLIFERYRLIKS
Sbjct: 421 GRKMYAEFYIKDNKVDLIFERYRLIKS 447
>pir||D71235 hypothetical protein PH0142 - Pyrococcus horikoshii
>gi|3256528|dbj|BAA29211.1| (AP000001) 289aa long
hypothetical protein [Pyrococcus horikoshii]
Length = 289
Score = 506 bits (1288), Expect = e-142
Identities = 240/286 (83%), Positives = 268/286 (92%)
Query: 1 MDVGKLESFIVEKMAERKVPGISISIIKDGDVVYAKGFGYRNVEARLPSTPETIYGIGSI 60
M+ +LESFIVEKM+E+KVPGISISIIKDG+V+YAKGFGYRNVEA+LPSTPETIYGIGSI
Sbjct: 4 MEFVELESFIVEKMSEKKVPGISISIIKDGEVIYAKGFGYRNVEAKLPSTPETIYGIGSI 63
Query: 61 TKSFTALAIMKLVEEGGLSLDDPVEKFVNIKLRPFGEPVTVHHLLTHSSGIPSLGYAEAF 120
TKSFTALAIMKL EEG LSL+DPVEK+VNIKLRPFG+PVT+HHLLTHSSGIPSLGYAEAF
Sbjct: 64 TKSFTALAIMKLAEEGALSLEDPVEKYVNIKLRPFGKPVTIHHLLTHSSGIPSLGYAEAF 123
Query: 121 IDGMVGGDNWLPVSTPEETIAFARDMEKWAVAKPGERFFYLNTGYVLLGKIIEKVSGVSY 180
I+GM+G D WLPV++P++ IAFA+DMEKWAVAKPGERFFYLNTGYVLLGKII KVSGV Y
Sbjct: 124 IEGMIGEDRWLPVASPDQIIAFAKDMEKWAVAKPGERFFYLNTGYVLLGKIISKVSGVPY 183
Query: 181 EEYIKKKILEPLGMNRSYFFKEEVEKDKDVAMGYILDKEGRLVPQPFPYGITADGGLLSS 240
EEY++KKILEPLGM RSYF KEEVEKDKDVAMGYI+DKEG+L+PQ FPYGIT+DGGLLS+
Sbjct: 184 EEYVRKKILEPLGMKRSYFSKEEVEKDKDVAMGYIVDKEGKLIPQGFPYGITSDGGLLSN 243
Query: 241 VLDLAKYLKMYIERDESIVSKEYIEKMETSYIKVPWEIFGGEGYGY 286
VLDLAKYLKMY+ERDE +VSKE IE ME YIKVPWE+FGGE YGY
Sbjct: 244 VLDLAKYLKMYMERDEKVVSKESIEAMEKPYIKVPWELFGGESYGY 289
>pir||A72725 probable beta-lactamase APE0338 - Aeropyrum pernix (strain K1)
>gi|5103977|dbj|BAA79293.1| (AP000059) 498aa long
hypothetical beta-lactamase [Aeropyrum pernix]
Length = 498
Score = 330 bits (837), Expect = 2e-89
Identities = 189/454 (41%), Positives = 276/454 (60%), Gaps = 25/454 (5%)
Query: 5 KLESFIVEKMAERKVPGISISIIKDGDVVYAKGFGYRNVEARLPSTPETIYGIGSITKSF 64
+LESFI+EKM+ ++P +++S K GDV A +GY ++E P++ +T YGIGSITKSF
Sbjct: 49 ELESFILEKMSRYRMPSLTLSAFKGGDVFQAS-YGYSSIEKGSPASVDTAYGIGSITKSF 107
Query: 65 TALAIMKLVEEGGLSLDDPVEKFVNIKLRPFGEPVTVHHLLTHSSGIPSLGYAEAFIDGM 124
TALA++ L EEG LSLDDPV + I L G+P+T+ HLLTH+SG+P+ YAEA + G
Sbjct: 108 TALAVLALEEEGKLSLDDPVGNHLGIDLEVEGQPITLEHLLTHTSGVPATAYAEALLRGF 167
Query: 125 VG-GDNWLPVSTPEETIAF-ARDMEK-WAVAKPGERFFYLNTGYVLLGKIIEKVSGVSYE 181
+G G W P S P + + + R ++K WAV+KPG RFFYLN GYV LG ++E+ SG SYE
Sbjct: 168 LGVGGYWKPYSRPWDAVLYLKRAIDKGWAVSKPGRRFFYLNEGYVALGIVVERSSGYSYE 227
Query: 182 EYIKKKILEPLGMNRSYFFKEEVEKDKDVAMGYILDKEG-RLVPQPFPYGITADGGLLSS 240
EYI++ + E LGM S F E +E A Y K G RL P P P GITADGG++S+
Sbjct: 228 EYIRRLVFEKLGMTSSGFIGERLE---HAATPY---KPGDRLEPVPLPAGITADGGIMST 281
Query: 241 VLDLAKYLKMYIERDESIVSKEYIEKMETSYIKVPWEIFGGEGYGYGLIIYPNFLGEKLV 300
D+ +Y++ + R E + Y E+ME ++VPW+ GGE YGYGLIIYP+F+G +L
Sbjct: 282 ARDMLRYVES-LARGE---FRGYAERMEKPRVRVPWQALGGEAYGYGLIIYPDFMGGRLA 337
Query: 301 GHSGSVGMYTGYIGYIPEKKIGVAVLENSSGYPPSYIAMYALALLLGKNPEKELPFIYRE 360
H GS+ YT ++GY GV +L N++GYP + + M L++L G + P +
Sbjct: 338 SHGGSLLAYTAWMGYSTRLDSGVVLLSNTTGYPLAAMGMAVLSVLSGGSHLDPKP-VRAL 396
Query: 361 RILKKVEGRYMGYKGTIKFEVKVDGDVVYLRALGRAFTYTIPLFPEVLE--------EDF 412
I++++EG Y G+ +I F ++ G + + +G + + L P + E
Sbjct: 397 EIVERLEGYYEGFDSSIAFNIRRVGTGLLVEPVGGVGS-PMALSPREIPGPGELEAGEGS 455
Query: 413 IKCYTLSNGRKMYAEFYIKDNKVDLIFERYRLIK 446
+ + G + EF +V+ + ERYRL+K
Sbjct: 456 VVFVSPYMGGVLEVEFNWSGERVEALLERYRLVK 489
>pir||E71235 hypothetical protein PH0143 - Pyrococcus horikoshii
>gi|3256529|dbj|BAA29212.1| (AP000001) 140aa long
hypothetical protein [Pyrococcus horikoshii]
Length = 140
Score = 245 bits (620), Expect = 6e-64
Identities = 113/139 (81%), Positives = 129/139 (92%)
Query: 308 MYTGYIGYIPEKKIGVAVLENSSGYPPSYIAMYALALLLGKNPEKELPFIYRERILKKVE 367
MYTGYIGYIPEK+IGVAVLENSSGYPPSYI MYALALLL KNPE+ELPF+ RE+ LK++E
Sbjct: 1 MYTGYIGYIPEKQIGVAVLENSSGYPPSYIGMYALALLLDKNPEEELPFLSREKKLKRIE 60
Query: 368 GRYMGYKGTIKFEVKVDGDVVYLRALGRAFTYTIPLFPEVLEEDFIKCYTLSNGRKMYAE 427
G Y GYKGT+KFEVKV+GD+VYL+ LG+ FTY +PLFPEVLEEDFIKCYTLSNGRKMYAE
Sbjct: 61 GLYKGYKGTLKFEVKVEGDIVYLKFLGKIFTYMVPLFPEVLEEDFIKCYTLSNGRKMYAE 120
Query: 428 FYIKDNKVDLIFERYRLIK 446
FYIKDN V+L+FERY+L+K
Sbjct: 121 FYIKDNTVELLFERYKLVK 139
>gb|AAF86053.1|AF210139_1 (AF210139) fmtA-like protein [Staphylococcus aureus]
Length = 498
Score = 142 bits (354), Expect = 9e-33
Identities = 115/341 (33%), Positives = 179/341 (51%), Gaps = 28/341 (8%)
Query: 5 KLESFIVEKMAERKVPGISISIIKDGDVVYAKGFGYRNVEARLPSTPETIYGIGSITKSF 64
++++ I + + +PG SI I+K+G V KG+GY++V+ ++ ++P T Y I S TK+F
Sbjct: 42 QIDTIIEHDLQKGHIPGASILIVKNGKVFLNKGYGYQDVDKKVKASPTTKYEIASNTKAF 101
Query: 65 TALAIMKLVEEGGLSLDDPVEKFV-NIKLRPFG--EPVTVHHLLTHSSGIPSLGYAEAFI 121
T LAI+KL +EG L+L+D V K V + K+ G E +T+ LL +SGIPS +E
Sbjct: 102 TGLAILKLAQEGRLNLNDAVSKHVPHFKMNYNGQNETITIKQLLAQTSGIPSDITSE--- 158
Query: 122 DGMVGGDNWLPVSTPEETIAFARDMEKWAVAKPGERFFYLNTGYVLLGKIIEKVSGVSYE 181
D + +N L + T A D KPGE F Y N Y LLG II+ V+ SY
Sbjct: 159 DSVTSKNNRL----NDVTHAIMGDE---LHHKPGEEFEYSNMNYDLLGLIIQNVTKQSYT 211
Query: 182 EYIKKKILEPLGMNRSYFFKEEVEKDKDVAMGYILDKEGRLVPQP-FPYGITADGGLLSS 240
+YI L+PL M + FK+ K K A+GY L +V +P F T +++S
Sbjct: 212 KYITNSWLKPLHMTHT-SFKQTNYKSKHDAIGYELQGSTPVVSKPEFNLWDTPSAYMMTS 270
Query: 241 VLDLAKYLKMYI---ERDESIVSKEYIEKMETSYIKVPWEIFGGEGYGYGLIIYPNFLGE 297
DL ++K + ++ +S+V + + K +S I P Y G + E
Sbjct: 271 TEDLEHWIKFQLNPPDKYKSLVQQSH--KNLSSTIGEP----NANAYASGWFTNND---E 321
Query: 298 KLVGHSGSVGMYTGYIGYIPEKKIGVAVLEN-SSGYPPSYI 337
LV HSG++ ++ +I P++ G+ VL N +S Y P +
Sbjct: 322 HLVFHSGTLDNFSSFILLNPKQNYGIVVLANLNSEYVPKLV 362
>sp|P32959|PBPE_BACSU PENICILLIN-BINDING PROTEIN 4* (PBP 4*) (PBP 4A)
>gi|541420|pir||A36908 spore cortex penicillin-binding
protein 4* pbpE - Bacillus subtilis
>gi|143290|gb|AAA22640.1| (L10629) penicillin-binding
protein [Bacillus subtilis] >gi|2635957|emb|CAB15449.1|
(Z99121) penicillin-binding protein 4* [Bacillus
subtilis]
Length = 451
Score = 125 bits (310), Expect = 1e-27
Identities = 114/435 (26%), Positives = 196/435 (44%), Gaps = 50/435 (11%)
Query: 10 IVEKMAERKVPGISISIIKDGDVVYAKGFGYRNVEARLPSTPETIYGIGSITKSFTALAI 69
+ E + E+ ++ + GD++Y FGY + + P +++ + S++K FTAL I
Sbjct: 12 LFETLGEKHQFNGTVLAAEGGDILYHHSFGYAEMTEKRPLKTNSLFELASLSKPFTALGI 71
Query: 70 MKLVEEGGLSLDDPVEKFVNIKLRPFGEPVTVHHLLTHSSGIPS-LGYAEAFIDGMVGGD 128
+ L E+G L +D V+++ + P+ + VT+ HLL H+SG+P +G+ A
Sbjct: 72 ILLEEKGILGYEDKVDRW--LPGFPY-QGVTIRHLLNHTSGLPDYMGWFFA--------- 119
Query: 129 NW--LPVSTPEETIAFARDMEKWAVAKPGERFFYLNTGYVLLGKIIEKVSGVSYEEYIKK 186
NW ++ ++ + + +P E + Y NTGYVLL IIEK SG+SY ++IK
Sbjct: 120 NWDSHKIAVNQDIVDMLMNEGLSGYFEPNEGWMYSNTGYVLLAVIIEKASGMSYADFIKT 179
Query: 187 KILEPLGMNRSYFFKEEV--EKDKDVAMGYILDKEGRLVPQP----------FPYGITAD 234
I P GMN + + + E+ A GY+ D P + GI D
Sbjct: 180 SIFLPAGMNETRVYNRRLSPERIDHYAYGYVYDVHSETYVLPDELEETNYVVYLDGIQGD 239
Query: 235 GGLLSSVLDLAKYLKMYIERDESIVSKEYIEKMETSYIKVPWEIFGGE--GYGYGLIIYP 292
G + S DL ++ D+++ ++I K P + GE YG+G ++
Sbjct: 240 GTVNSVTSDLFRF-------DQALYQDDFISKASKESAFSPVRLNNGETIDYGFGWVLQN 292
Query: 293 NFLGEKLVGHSGS-VGMYTGYIGYIPEKK--IGVAVLENSSGYPPSYIAMYALALLLG-- 347
+ ++V HSG G T I YI +K I ++ E + Y + I A +L G
Sbjct: 293 SPEKGRIVSHSGGWPGYSTMMIRYIDHRKTLIYLSNKEEDTEYEQA-ILKAAEHILFGQP 351
Query: 348 ----KNPEKELPFIYRERILKKVEGRYMGYKGTIKFEVKVDGDVVYLRALGRAFTYTIPL 403
+ P + I + G Y+ GT +V + + +YL G+ + L
Sbjct: 352 YDVPERPADKKKKAIDTAIYSRYVGSYLLQDGTAA-QVTTENERLYLEIAGQ---LRLEL 407
Query: 404 FPEVLEEDFIKCYTL 418
FP F++ ++
Sbjct: 408 FPSSETRFFLRALSV 422
>emb|CAB08016.1| (Z94043) penicillin-binding protein [Bacillus subtilis]
Length = 456
Score = 125 bits (310), Expect = 1e-27
Identities = 114/435 (26%), Positives = 196/435 (44%), Gaps = 50/435 (11%)
Query: 10 IVEKMAERKVPGISISIIKDGDVVYAKGFGYRNVEARLPSTPETIYGIGSITKSFTALAI 69
+ E + E+ ++ + GD++Y FGY + + P +++ + S++K FTAL I
Sbjct: 17 LFETLGEKHQFNGTVLAAEGGDILYHHSFGYAEMTEKRPLKTNSLFELASLSKPFTALGI 76
Query: 70 MKLVEEGGLSLDDPVEKFVNIKLRPFGEPVTVHHLLTHSSGIPS-LGYAEAFIDGMVGGD 128
+ L E+G L +D V+++ + P+ + VT+ HLL H+SG+P +G+ A
Sbjct: 77 ILLEEKGILGYEDKVDRW--LPGFPY-QGVTIRHLLNHTSGLPDYMGWFFA--------- 124
Query: 129 NW--LPVSTPEETIAFARDMEKWAVAKPGERFFYLNTGYVLLGKIIEKVSGVSYEEYIKK 186
NW ++ ++ + + +P E + Y NTGYVLL IIEK SG+SY ++IK
Sbjct: 125 NWDSHKIAVNQDIVDMLMNEGLSGYFEPNEGWMYSNTGYVLLAVIIEKASGMSYADFIKT 184
Query: 187 KILEPLGMNRSYFFKEEV--EKDKDVAMGYILDKEGRLVPQP----------FPYGITAD 234
I P GMN + + + E+ A GY+ D P + GI D
Sbjct: 185 SIFLPAGMNETRVYNRRLSPERIDHYAYGYVYDVHSETYVLPDELEETNYVVYLDGIQGD 244
Query: 235 GGLLSSVLDLAKYLKMYIERDESIVSKEYIEKMETSYIKVPWEIFGGE--GYGYGLIIYP 292
G + S DL ++ D+++ ++I K P + GE YG+G ++
Sbjct: 245 GTVNSVTSDLFRF-------DQALYQDDFISKASKESAFSPVRLNNGETIDYGFGWVLQN 297
Query: 293 NFLGEKLVGHSGS-VGMYTGYIGYIPEKK--IGVAVLENSSGYPPSYIAMYALALLLG-- 347
+ ++V HSG G T I YI +K I ++ E + Y + I A +L G
Sbjct: 298 SPEKGRIVSHSGGWPGYSTMMIRYIDHRKTLIYLSNKEEDTEYEQA-ILKAAEHILFGQP 356
Query: 348 ----KNPEKELPFIYRERILKKVEGRYMGYKGTIKFEVKVDGDVVYLRALGRAFTYTIPL 403
+ P + I + G Y+ GT +V + + +YL G+ + L
Sbjct: 357 YDVPERPADKKKKAIDTAIYSRYVGSYLLQDGTAA-QVTTENERLYLEIAGQ---LRLEL 412
Query: 404 FPEVLEEDFIKCYTL 418
FP F++ ++
Sbjct: 413 FPSSETRFFLRALSV 427
>dbj|BAB04434.1| (AP001509) unknown conserved protein [Bacillus halodurans]
Length = 478
Score = 125 bits (310), Expect = 1e-27
Identities = 95/340 (27%), Positives = 161/340 (46%), Gaps = 39/340 (11%)
Query: 6 LESFIVEKMAERKVPGISISIIKDGDVVYAKGFGYRNVEARLPSTPETIYGIGSITKSFT 65
L++++ + ++PG +I+I++D + +YAK +G T ET + IGS+TKS T
Sbjct: 34 LDNYVETFLGTHRIPGAAIAIVQDRETIYAKSWGVTGGSEEAV-TLETPFLIGSVTKSLT 92
Query: 66 ALAIMKLVEEGGLSLDDPVEKFV---NIKLRPFGEPVTVHHLLTHSSGIPSLGYAEAFID 122
ALAI+KL++E + LDDPV+ + ++ R +T+ HLL H+SG+ + Y I
Sbjct: 93 ALAIVKLLDENKIMLDDPVQAHLPWFTLQDRAAATQITIRHLLAHTSGLST--YTGLAIA 150
Query: 123 GMVGGDNWLPVSTPEETIAFARDME-KWAVAKPGERFFYLNTGYVLLGKIIEKVSGVSYE 181
D ++ R++ + A PGE+ Y N Y++LG ++E+VSG +
Sbjct: 151 DQGSADE-------NAIVSHVRNLATEELTADPGEQHQYSNANYLILGALVEEVSGQPFS 203
Query: 182 EYIKKKILEPLGMNRSYFFKEEVEKDKDVAMGYILDKEGRLVPQPFPY--GITADGGLLS 239
EY+K++I LGM + + V ++ +G G V Y G T G + +
Sbjct: 204 EYMKQQIFSSLGMEHA--AADHVTAARNGYLGSYQSWFGFPVKSRVSYDNGGTPYGYIAA 261
Query: 240 SVLDLAKYLK---------MYIERDESIVSKEYIEKMETSYIKVPWEIFGGEGYGYGLII 290
S D+A ++K E S +++ E Y YG+GL +
Sbjct: 262 SAEDIASFIKFLQGNGPNDFLTEESLSFYLSPLVQQRENRY------------YGFGLRL 309
Query: 291 YPNFLGEKLVGHSGSVGMYTGYIGYIPEKKIGVAVLENSS 330
GE ++ HSG+ + +PE K G +L N +
Sbjct: 310 TTFDSGETMIWHSGATPDSRAELFILPEHKWGGVILTNKN 349
>pir||E70687 hypothetical protein Rv1730c - Mycobacterium tuberculosis (strain
H37RV) >gi|1654032|emb|CAB03693.1| (Z81360) hypothetical
protein Rv1730c [Mycobacterium tuberculosis]
Length = 517
Score = 122 bits (304), Expect = 6e-27
Identities = 91/340 (26%), Positives = 167/340 (48%), Gaps = 29/340 (8%)
Query: 5 KLESFIVEKMAERKVPGISISIIKDGDVVYAKGFGYRNVEARLPSTPETIYGIGSITKSF 64
+L++ I M +PG+++++ G Y KG+G NV+ +P +T++ IGS TK+F
Sbjct: 59 ELDAKINAGMKAYAIPGVAVAVWAGGQE-YVKGYGVTNVDHPMPVDGDTVFRIGSTTKTF 117
Query: 65 TALAIMKLVEEGGLSLDDPVEKFV---NIKLRPFGEPVTVHHLLTHSSGIPSLGYAEAFI 121
T +M+LVE G + LD PV +++ + VTV LL H++G
Sbjct: 118 TGTVMMRLVERGKVDLDSPVRRYIPDFAVADESASATVTVRQLLNHTAG----------W 167
Query: 122 DGMVGGDNWLPVSTPEETIA-FARDMEKW-AVAKPGERFFYLNTGYVLLGKIIEKVSGVS 179
DG G D ++ +A + + M + + PG F Y N+G V+ G+IIE V+G +
Sbjct: 168 DGRNGQD----FGRGDDAVALYVKAMTRLPQLTPPGTAFAYNNSGLVVAGRIIELVAGTT 223
Query: 180 YEEYIKKKILEPLGMNRSYFFKEEVEKDKDVAMGYILDKEGRLVPQ--PFPYGITADGGL 237
YE +++ +L+PL + + +F +++ A ++D + V FP GGL
Sbjct: 224 YESTVQRLLLDPLQLAHTRYFSDQIIGLNVAASHSVVDGKPIAVTDFWTFPRSCNPTGGL 283
Query: 238 LSSVLDLAKYLKMYI-----ERDESIVSKEYIEKMETSYIKVPWEIFGGEGYGYGLIIYP 292
+S+ D +Y + ++ E I+S++ ++ M ++ G G ++ P
Sbjct: 284 MSTARDQLRYAQFHLGDGRAPNGEQILSRQSLKAMRSNPGAGGTLWVELTGMGVTWMLRP 343
Query: 293 NFLGEKLVGHSGS-VGMYTGYIGYIPEKKIGVAVLENSSG 331
+ +V H G+ G +G++ +P++ + VL NS G
Sbjct: 344 SAENVTIVEHGGTWKGQRSGFV-MVPDRNFAMTVLTNSDG 382
>dbj|BAB05986.1| (AP001515) penicillin-binding protein [Bacillus halodurans]
Length = 332
Score = 120 bits (297), Expect = 4e-26
Identities = 92/284 (32%), Positives = 152/284 (53%), Gaps = 24/284 (8%)
Query: 14 MAERKVPGISISIIKDGDVVYAKGFGYRNVEARLPSTPETIYGIGSITKSFTALAIMKLV 73
M + K+ G ++ + K D+ + G+ N R+P+ T +GI S K FTA+AI +LV
Sbjct: 9 MEDWKLSGTAL-MKKGEDIPFIASLGFANRAERIPNEHHTRFGIASGCKLFTAIAICQLV 67
Query: 74 EEGGLSLDDPVEKFVNIKLRPFGEPVTVHHLLTHSSGIPSLGYAEAFIDGMVGGDNWLPV 133
E G LS D P+ +++ PF VT+HHLLTH+SG+P + E D D W V
Sbjct: 68 EAGKLSFDTPLSDWLDA---PFPN-VTIHHLLTHTSGVPDY-FDEEITDDFE--DLWKDV 120
Query: 134 STPEETIAFARD---MEKWAVAK--PGERFFYLNTGYVLLGKIIEKVSGVSYEEYIKKKI 188
P + +D + + A K PG RF Y N G++LLG ++E VSGV+++EY++ +
Sbjct: 121 --PMYHLRRLKDFLPLFQHAPMKFPPGHRFHYNNAGFILLGLVVESVSGVTFQEYVEANV 178
Query: 189 LEPLGMNRSYFFKEEVEKDKDVAMGYILDKEGRLVPQPFPYGIT--ADGGLLSSVLDLAK 246
+ GM+ S +F + K A+GYI ++G + + +DGG + D+ K
Sbjct: 179 FQRAGMHESGYFAFDTLPAK-TALGYIDLEDGSWKTNLYSLPVIGGSDGGAYVTAEDMMK 237
Query: 247 YLKMYIERDESIVSKEYIEKMETSYIKVPWEIFGGEGYGYGLII 290
L + + R E ++++ Y +K+ T ++ + + YGYG+ I
Sbjct: 238 -LWLALMRHE-LLNETYTQKLLTPHVHCEDDDY----YGYGVWI 275
>pir||E82658 beta-lactamase XF1621 [imported] - Xylella fastidiosa (strain
9a5c) >gi|9106673|gb|AAF84430.1|AE003989_7 (AE003989)
beta-lactamase [Xylella fastidiosa]
Length = 455
Score = 118 bits (293), Expect = 1e-25
Identities = 88/366 (24%), Positives = 170/366 (46%), Gaps = 26/366 (7%)
Query: 2 DVGKLESFIVEKMAERKVPGISISIIKDGDVVYAKGFGYRNVEARLPSTPETIYGIGSIT 61
D+ +ES + +KVPG++++I++ G ++ +G+G +V P T++ + S++
Sbjct: 61 DIKAIESMAEQLTYGQKVPGLAMAIVQGGHILSMRGYGVNDVSNPQPVNAHTVFRLASLS 120
Query: 62 KSFTALAIMKLVEEGGLSLDDPVEKFV---NIKLRPFGEPVTVHHLLTHSSGIPSLGYAE 118
K+F + LV +G LS + + +V ++ +TV +L+H G+ Y
Sbjct: 121 KAFASAMAGLLVNDGILSWNSKIVDYVPGFHLSNPTATNKLTVADVLSHRVGLSRNAY-- 178
Query: 119 AFIDGMVGGDNWLPVSTPEETIAFARDMEKWAVAKPGERFFYLNTGYVLLGKIIEKVSGV 178
DG + ++ + +A+A + PGE + Y N + L+G ++ SG
Sbjct: 179 ---DGEI--ESNADYYSLNRKLAYAP-----LICSPGECYSYQNVAFSLIGDVVFAASGD 228
Query: 179 SYEEYIKKKILEPLGMNRSYFFKEEVEKDKDVAMGYILDKEG--RLVPQPFPYGITADGG 236
YE+ ++++I +PLGMN + + + A + K+G +V + Y + G
Sbjct: 229 FYEQAVERRIFKPLGMNDASLGLAGIRSSQSWARPHTRTKKGWRPVVVKQTYYHLAPAAG 288
Query: 237 LLSSVLDLAKYLKMYIERDESIVSKEYIEKMETSYIKVPWEIFGG--------EGYGYGL 288
+ +S D+A++L ++ + + T + P E+ G Y G
Sbjct: 289 VNASASDMAQWLLAQTGHKPEVLPAPLLVTLHTPLVSTPSEVRPGWREQRLLAASYALGW 348
Query: 289 IIYPNFLGEKLVGHSGSVGMYTGYIGYIPEKKIGVAVLENSSGYPPSYIAMYALALLLGK 348
++ N+ G LV H+G+V Y G + +PE+ GVA+L N PS + + L +LG
Sbjct: 349 RLF-NYNGHTLVFHAGAVQGYRGLVALLPERDFGVAILCNGETGLPSGLLLTILDRVLGL 407
Query: 349 NPEKEL 354
+ L
Sbjct: 408 RGQHRL 413
>pir||S75832 penicillin-binding protein 4 - Synechocystis sp. (strain PCC 6803)
>gi|1653377|dbj|BAA18291.1| (D90913) penicillin-binding
protein 4 [Synechocystis sp.]
Length = 414
Score = 113 bits (279), Expect = 6e-24
Identities = 92/322 (28%), Positives = 163/322 (50%), Gaps = 37/322 (11%)
Query: 2 DVGKLESFIVEKMAE---RKVPGISISIIKDGDVVYAKGFGYRNVEARLPSTPE-TIYGI 57
D L ++++++ + +++ ++++I +G V G NV++ P PE T+Y +
Sbjct: 21 DRASLNQYLIDRLNQGEGKELGSAALALIHNGKVDTIHTVGVENVDSGSPVDPENTLYQM 80
Query: 58 GSITKSFTALAIMKLVEEGGLSLDDPVEKFVNIKLRPFGEP----VTVHHLLTHSSGIPS 113
S++K TA +MKLVE G ++LDDPV + P P VT+ LL+H+ G
Sbjct: 81 ASVSKLVTAWGVMKLVEMGQINLDDPVLSHLRRWQFPADSPYRGEVTIAQLLSHTGGQND 140
Query: 114 -LGYAEAFIDGMVGGDNWLPVSTPEETIAFARDMEKW------AVAKPGERFFYLNTGYV 166
LGY F+ G P+ T E+++ +D+ AV PGE F Y GY
Sbjct: 141 HLGYG-GFLPGQ-------PLQTLEQSLTLTKDVAFGEPRGVEAVYPPGEEFSYSGGGYT 192
Query: 167 LLGKIIEKVSGVSYEEYIKKKILEPLGMNRSYFFKEEVEKDKDVAMGYILDKEGRLVPQP 226
+L ++E+V+G S+ E+++++IL PLGM + F + D+ A L P P
Sbjct: 193 VLQLLVEEVTGQSFAEFMQEQILHPLGMTGANFDWPTI-VDQGRANNLATSFTEDLQPSP 251
Query: 227 FPYGITADG--GLLSSVLDLAKYLKMYIERDESIVSKEYIEKMETSYIKVPWEIFGGEG- 283
P TA G L +S+ D+ K+ + +++ S++ + +++M T+ G +G
Sbjct: 252 -PRHFTATGAASLYASLADMVKFAQAHLQ-PNSVLKADTLQRMATAQP-------GTDGT 302
Query: 284 YGYGLIIYPNFL-GEKLVGHSG 304
+G G+++Y G ++GH G
Sbjct: 303 WGLGMMLYQTTTSGGAVIGHDG 324
>pir||C69673 penicillin-binding protein pbpX - Bacillus subtilis
>gi|2634067|emb|CAB13568.1| (Z99112) penicillin-binding
protein [Bacillus subtilis]
Length = 391
Score = 109 bits (270), Expect = 6e-23
Identities = 77/245 (31%), Positives = 132/245 (53%), Gaps = 22/245 (8%)
Query: 26 IIKDGDVVYAKGFGYRNVEARLPSTPETIYGIGSITKSFTALAIMKLVEEGGLSLDDPVE 85
I+++G++V KGFGY + + + + P T + +GS K+ A AI++L E+G L DPV
Sbjct: 101 IVRNGEIVTNKGFGYADRKHYIQNNPLTSFYVGSSQKALIATAILQLEEKGKLQTSDPVS 160
Query: 86 KFVNIKLRPFGEPVTVHHLLTHSSGIPSLGYAEAFIDGMVGGDNWLPVSTPEETIAFARD 145
+ + P G+ +T+ +LLTH+SG I+G + G+ + TP++ I +D
Sbjct: 161 TY--LPHFPNGQTITLKNLLTHTSG----------INGHIEGNGAI---TPDDLI---KD 202
Query: 146 MEKWAVAKPGERFFYLNTGYVLLGKIIEKVSGVSYEEYIKKKILEPLGMNRSYFFKEEVE 205
+E + + + Y ++ Y +L II +VSG YE+YIK I +P GM + F+K E
Sbjct: 203 IELQGIKRQPGVWDYKDSNYSVLAYIIAEVSGEPYEQYIKNHIFKPAGMTHAGFYK-TYE 261
Query: 206 KDKDVAMGYILDKEGRLVPQ-PFPYGITADGGLLSSVLDLAKYLKMYIERDESIVSKEYI 264
K+ A+GY ++ + P P + G + S +D+ K+ + I D + S++
Sbjct: 262 KEPYPAVGYKMEGSKTVTPYIPDLSQLYGAGDIYMSAIDMYKFDQALI--DGKLYSQKSY 319
Query: 265 EKMET 269
EKM T
Sbjct: 320 EKMFT 324
>dbj|BAA13079.1| (D86380) Alkaline D-peptidase [Bacillus cereus]
Length = 388
Score = 108 bits (266), Expect = 2e-22
Identities = 98/322 (30%), Positives = 162/322 (49%), Gaps = 30/322 (9%)
Query: 20 PGISISIIKDGDVVYAKGFGYRNVEARLPSTPETIYGIGSITKSFTALAIMKLVEEGGLS 79
PGI ++ +G ++ G N+ ++ P + + IGS+TK+FTA +++L EE L+
Sbjct: 66 PGI-LAKTSEGGKTWSYAAGVANLSSKKPMKTDFRFRIGSVTKTFTATVVLQLAEENRLN 124
Query: 80 LDDPVEKFVNIKLRPFG---EPVTVHHLLTHSSGIPSLGYAEAFIDGMVGGDNWLPVSTP 136
LDD +EK++ ++ G + +T+ LL H+SGI +++F D M ++
Sbjct: 125 LDDSIEKWLPGVIQGNGYDDKQITIRQLLNHTSGIAEYTRSKSF-DLMDTKKSYRAEELV 183
Query: 137 EETIAFARDMEKWAVAKPGERFFYLNTGYVLLGKIIEKVSGVSYEEYIKKKILEPLGMNR 196
+ I+ D PG+ + Y NTGYVLLG +IE V+G SY E I+ +I+EPL ++
Sbjct: 184 KMGISMPPDFA------PGKSWSYSNTGYVLLGILIETVTGNSYAEEIENRIIEPLELSN 237
Query: 197 SYF-FKEEVEKDKDVAMGYILDKEGRLVPQPFPY-----GITADGGLLSSVLDLAKYLKM 250
++ V A GYI +G P+ Y G +A G ++S+ DL K+
Sbjct: 238 TFLPGNSSVIPGTKHARGYI-QLDGASEPKDVTYYNPSMGSSA-GDMISTADDLNKFFSY 295
Query: 251 YIERDESIVSKEYIEKMETSYIKVPWEIFGGEGYG-YGLIIYPNFL--GEKLVGHSGSVG 307
+ ++ ++ +++M T+ VP G G YGL IY L G + GH GS+
Sbjct: 296 LL--GGKLLKEQQLKQMLTT---VP---TGEAALGRYGLGIYETKLPNGVSIWGHGGSIP 347
Query: 308 MYTGYIGYIPEKKIGVAVLENS 329
+ + G K +AV NS
Sbjct: 348 GFVTFAGGTLGGKHTLAVNLNS 369
>pir||T35155 hypothetical protein SC5A7.06c SC5A7.06c - Streptomyces coelicolor
>gi|3334787|emb|CAA19935.1| (AL031107) hypothetical
protein SC5A7.06c [Streptomyces coelicolor A3(2)]
Length = 409
Score = 107 bits (265), Expect = 2e-22
Identities = 76/277 (27%), Positives = 137/277 (49%), Gaps = 25/277 (9%)
Query: 3 VGKLESFIVEKMAERKVPGISISIIKDGDVVYAKGFGYRNVEARLPSTPETIYGIGSITK 62
+ +L+ ++ E ++PG +++ + G V + G R+V A LP T +T++ I S+TK
Sbjct: 20 LARLDLHFARQVDEGRLPGFLVAVARGGRVAHLTVHGLRDVAAGLPVTADTLWRIYSMTK 79
Query: 63 SFTALAIMKLVEEGGLSLDDPVEKFV---------------NIKLRPFGEPVTVHHLLTH 107
T++A++ LVEEG L+LDDPV++++ N+ RP PV V HL+TH
Sbjct: 80 PVTSVAVLTLVEEGRLALDDPVDRYLPAFAEPRVYVGGTGENVVTRPATGPVRVRHLMTH 139
Query: 108 SSGIPSLGYAEAFIDGMVGGDNWLPVSTPEETIAFARDMEKWAVAK--PGERFFYLNTGY 165
++G+ Y +D + P +A D+ + PG + Y +
Sbjct: 140 TAGLTFGFYRTHPVDALYRAAGVESSVRPGADLAETVDLYASLPLQFDPGTEWNY-SVAS 198
Query: 166 VLLGKIIEKVSGVSYEEYIKKKILEPLGMNRSYFFKEEVEKDKDVAMGYILDKEGRLVPQ 225
+LG+++E VSG + + ++I PLGM + F + + + +A Y ++G + P
Sbjct: 199 NVLGRLVEVVSGQPLDVFCAERIFGPLGMTDTGFHVADAQAGR-LAELYGETEDGGIAPV 257
Query: 226 P------FPYGITADGGLLSSVLDLAKYLKMYIERDE 256
P P ++ GGL SS D+ ++ ++ R E
Sbjct: 258 PGLPLLGRPRFLSGSGGLASSAYDVHRFAELLRRRGE 294
>pir||F70634 hypothetical protein Rv1922 - Mycobacterium tuberculosis (strain
H37RV) >gi|1806240|emb|CAB06504.1| (Z84498) hypothetical
protein Rv1922 [Mycobacterium tuberculosis]
Length = 371
Score = 104 bits (258), Expect = 2e-21
Identities = 88/323 (27%), Positives = 156/323 (48%), Gaps = 23/323 (7%)
Query: 20 PGISISIIKDGDVVYAKGFGYRNVEARLPSTPETIYGIGSITKSFTALAIMKLVEEGGLS 79
PG S ++ +G V+++ G ++ + T +T++ I S++K FTA AI+ LVE G L+
Sbjct: 60 PGCSAAVGVEGKVIWSGVRGIADLASGAKITTDTVFDIASVSKQFTATAILLLVEAGKLT 119
Query: 80 LDDPVEKFVNIKLRPFGEPVTVHHLLTHSSGIPSLGYAEAFIDGMVGGDNWLPVSTPEET 139
LDDP+ ++V +L + + VTV L+ +SGIP A G D + +
Sbjct: 120 LDDPISQYVP-ELPDWAQTVTVEQLMHQTSGIPDY-VALLAARGYQVSDRTIEAEA-RQA 176
Query: 140 IAFARDMEKWAVAKPGERFFYLNTGYVLLGKIIEKVSGVSYEEYIKKKILEPLGMNRSYF 199
+A A +++ KPG RF Y N+ Y+LLG+I+ + SG E++ +I +PLG+
Sbjct: 177 LAAAPELQ----FKPGTRFDYSNSNYLLLGEIVHRASGQPLPEFLSAEIFQPLGL---AM 229
Query: 200 FKEEVEKDKDVAMGYILDKEGR----LVPQPFPYGITADGGLLSSVLDLAKYLKMYIERD 255
+ V K + A+ Y G V P + DGG+ ++ LA++ Y R
Sbjct: 230 VVDPVGKVPNKAVSYEKGTGGNRSEYRVGNP-AWEQIGDGGIQTTPSQLARWADNY--RT 286
Query: 256 ESIVSKEYIEKMETSYIKVPWEIFGGEGYGYGLIIYPNFLGEKLVGHSGSVGMYTGYIGY 315
S+ + +E ++ E GG+ YG G++ + + H+G+ +
Sbjct: 287 GSVGGLKLLEAQLAGAVET--EPGGGDRYGAGIV----SRADGTLDHAGAWAGFVTAFHI 340
Query: 316 IPEKKIGVAVLENSSGYPPSYIA 338
+++ VA+ N+ P +A
Sbjct: 341 SSDRRTSVAISCNTDKPDPVAMA 363
>emb|CAA09676.1| (AJ011526) D-stereospecific peptide hydrolase [Bacillus cereus]
Length = 389
Score = 104 bits (256), Expect = 3e-21
Identities = 83/302 (27%), Positives = 150/302 (49%), Gaps = 20/302 (6%)
Query: 20 PGISISIIKDGDVVYAKGFGYRNVEARLPSTPETIYGIGSITKSFTALAIMKLVEEGGLS 79
PGI ++ +G + G ++ + P + + IGS+TK+FTA +++LV E L
Sbjct: 66 PGI-LAKTSEGGKTWGYAAGIADLRTKKPMKTDFRFRIGSVTKTFTATVVLQLVGENRLK 124
Query: 80 LDDPVEKFVNIKLRPFG---EPVTVHHLLTHSSGIPSLGYAEAFIDGMVGGDNWLPVSTP 136
LDD +E ++ ++ G +T+ +L H+SGI ++ +D ++
Sbjct: 125 LDDHIEDWLPGVIQGNGYDGNKITIQEILNHTSGIAEYSRSKD-VDFTDTKKSYTAEELV 183
Query: 137 EETIAFARDMEKWAVAKPGERFFYLNTGYVLLGKIIEKVSGVSYEEYIKKKILEPLGMNR 196
+ I+F D PG+ + Y NTGYVLLG +IEKV+G SY E ++ +I+EPL ++
Sbjct: 184 KMGISFPPDFA------PGKGWSYSNTGYVLLGILIEKVTGNSYAEEVENRIIEPLELSN 237
Query: 197 SYF-FKEEVEKDKDVAMGYILD---KEGRLVPQPFPYGITADGGLLSSVLDLAKYLKMYI 252
++ V + A GY+ E + V P ++ G ++S+ DL K+ +
Sbjct: 238 TFLPGNSSVIPGTNHARGYVQPDGASELKDVTYYNPSAGSSAGDMISTADDLNKFFSYLL 297
Query: 253 ERDESIVSKEYIEKMETSYIKVPWEIFGGEGYGYGLIIYPNFLGEKLVGHSGSVGMYTGY 312
++ ++ +++M T+ VP G +GYG G+ G + GH+G + +T
Sbjct: 298 --GGKLLKEQQLKQMLTT---VPTGKEGIDGYGLGIYETKLPSGVSIWGHTGGILGFTTL 352
Query: 313 IG 314
+G
Sbjct: 353 VG 354
>gb|AAD28043.1|AF124203_1 (AF124203) beta-lactamase precursor [Escherichia coli]
>gi|4691722|gb|AAD28044.1|AF124204_1 (AF124204)
beta-lactamase precursor [Escherichia coli]
>gi|4691724|gb|AAD28045.1|AF124205_1 (AF124205)
beta-lactamase precursor [Escherichia coli]
Length = 377
Score = 102 bits (251), Expect = 1e-20
Identities = 84/361 (23%), Positives = 168/361 (46%), Gaps = 57/361 (15%)
Query: 10 IVEKMAERKVPGISISIIKDGDVVYAKGFGYRNVEARLPSTPETIYGIGSITKSFTALAI 69
I + ++K+PG+++++I G Y +GY ++ + P T +T++ +GS++K+FT +
Sbjct: 32 ITPLIEQQKIPGMAVAVIYQGKPYYFT-WGYADIAKKQPVTQQTLFELGSVSKTFTGVLG 90
Query: 70 MKLVEEGGLSLDDPVEKFVNIKLRPFGEPVTVHHLLTHSSGIPSLGYAEAFIDGMVGGDN 129
+ G + L DP K+ +T+ HL T+++G
Sbjct: 91 GDAIARGEIKLSDPATKYWPELTAKQWNGITLLHLATYTAG------------------- 131
Query: 130 WLPVSTPEETIA---FARDMEKWAVA-KPGERFFYLNTGYVLLGKIIEKVSGVSYEEYIK 185
LP+ P+E + R + W A PG + Y N+ L G + K SG+S+E+ ++
Sbjct: 132 GLPLQVPDEVKSSSDLLRFYQNWQPAWAPGTQRLYANSSIGLFGALAVKPSGLSFEQAMQ 191
Query: 186 KKILEPLGMNRSYFFKEEVEKDKDVAMGYILDKEGRLVPQPFPYGITADG-GLLSSVLDL 244
++ +PL +N ++ E +K+ A GY +EG+ V P + A+ G+ S++ D+
Sbjct: 192 TRVFQPLKLNHTWINVPPPE-EKNYAWGY---REGKAV-HVSPGALDAEAYGVKSTIEDM 246
Query: 245 AKYLKMYIE----RDESI-----VSKEYIEKMETSYIKVPWE----------IFGGEGYG 285
A++++ + D+++ +++ + Y + WE I G G
Sbjct: 247 ARWVRSNMNPRDINDKTLQQGIQLAQSRYWQTGDMYQGLGWEMLDWPVNPDSIINGNGNK 306
Query: 286 YGLIIYP--------NFLGEKLVGHSGSVGMYTGYIGYIPEKKIGVAVLENSSGYPPSYI 337
L +P + V +G+ G + Y+ +IPEK++G+ +L N + P+ +
Sbjct: 307 IALAAHPVKAITPPTPAVRASWVHKTGATGGFGSYVAFIPEKELGIVMLANKNYPNPARV 366
Query: 338 A 338
A
Sbjct: 367 A 367
>gb|AAD28041.1|AF124201_1 (AF124201) beta-lactamase precursor [Escherichia coli]
Length = 377
Score = 101 bits (250), Expect = 1e-20
Identities = 85/361 (23%), Positives = 168/361 (45%), Gaps = 57/361 (15%)
Query: 10 IVEKMAERKVPGISISIIKDGDVVYAKGFGYRNVEARLPSTPETIYGIGSITKSFTALAI 69
I + ++K+PG+++++I G Y +GY ++ + P T +T++ +GS++K+FT +
Sbjct: 32 ITPLIEQQKIPGMAVAVIYQGKPYYFT-WGYADIAKKQPVTQQTLFELGSVSKTFTGVLG 90
Query: 70 MKLVEEGGLSLDDPVEKFVNIKLRPFGEPVTVHHLLTHSSGIPSLGYAEAFIDGMVGGDN 129
+ + G + L DP K+ +T+ HL T+++G
Sbjct: 91 GEAIARGEIKLSDPTTKYWPELTAKQWNGITLLHLATYTAG------------------- 131
Query: 130 WLPVSTPEETIA---FARDMEKWAVA-KPGERFFYLNTGYVLLGKIIEKVSGVSYEEYIK 185
LP+ P+E + R + W A PG + Y N+ L G + K SG+S+E+ ++
Sbjct: 132 GLPLQVPDEVKSSSDLLRFYQNWQPAWAPGTQRLYANSSIGLFGALAVKPSGLSFEQAMQ 191
Query: 186 KKILEPLGMNRSYFFKEEVEKDKDVAMGYILDKEGRLVPQPFPYGITADG-GLLSSVLDL 244
++ +PL +N ++ E +K+ A GY +EG+ V P + A+ G+ S++ D+
Sbjct: 192 TRVFQPLKLNHTWINVPPAE-EKNYAWGY---REGKAV-HVSPGALDAEAYGVKSTIEDM 246
Query: 245 AKYLKMYIE----RDESI-----VSKEYIEKMETSYIKVPWE----------IFGGEGYG 285
A +++ + D+++ +++ + Y + WE I G G
Sbjct: 247 ACWVRSNMNPRDINDKTLQQGIQLAQSRYWQTGDMYQGLGWEMLDWPVNPDSIINGSGNK 306
Query: 286 YGLIIYP--------NFLGEKLVGHSGSVGMYTGYIGYIPEKKIGVAVLENSSGYPPSYI 337
L +P + V +GS G + Y+ +IPEK++G+ +L N + P+ +
Sbjct: 307 IVLAAHPVKAITPPTPAVRASWVHKTGSTGGFGSYVAFIPEKELGIVMLANKNYPNPARV 366
Query: 338 A 338
A
Sbjct: 367 A 367
>pir||S08296 beta-lactamase (EC 3.5.2.6) precursor - Citrobacter freundii
(strain GN346) >gi|40458|emb|CAA35959.1| (X51632)
beta-lactamase [Citrobacter freundii]
Length = 381
Score = 100 bits (247), Expect = 3e-20
Identities = 89/356 (25%), Positives = 163/356 (45%), Gaps = 58/356 (16%)
Query: 10 IVEKMAERKVPGISISIIKDGDVVYAKGFGYRNVEARLPSTPETIYGIGSITKSFTALAI 69
I M E+ +PG++++II +G Y +G ++ P T +T++ +GS++K+F +
Sbjct: 36 ITPLMQEQAIPGMAVAIIYEGKPYYFT-WGKADIANNHPVTQQTLFELGSVSKTFNGVLG 94
Query: 70 MKLVEEGGLSLDDPVEKFVNIKLRPFGEPVTVHHLLTHSSGIPSLGYAEAFIDGMVGGDN 129
+ G + L DPV K+ +++ HL T+++G
Sbjct: 95 GDAIARGEIKLSDPVTKYWPELTGKQWRGISLLHLATYTAG------------------- 135
Query: 130 WLPVSTPEETI---AFARDMEKWAVA-KPGERFFYLNTGYVLLGKIIEKVSGVSYEEYIK 185
LP+ P++ A R + W PG + Y N+ L G + K SG+SYEE +
Sbjct: 136 GLPLQIPDDITDKAALLRFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMT 195
Query: 186 KKILEPLGMNRSYFFKEEVEKDKDVAMGYILDKEGRLVPQPFPYGITADG-GLLSSVLDL 244
+++L+PL + ++ + E+ K+ A GY +EG+ V P + A+ GL SSV+D+
Sbjct: 196 RRVLQPLKLAHTWITVPQSEQ-KNYAWGY---REGKPV-HVSPGQLDAEAYGLKSSVIDM 250
Query: 245 AKYLKMYIERD--ESIVSKEYIEKMETSYIKV-------PWE----------IFGGEGYG 285
A++++ ++ + ++ IE ++ Y ++ WE I G
Sbjct: 251 ARWVQANMDASHVQEKTLQQGIELAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSK 310
Query: 286 YGLIIYPNF--------LGEKLVGHSGSVGMYTGYIGYIPEKKIGVAVLENSSGYP 333
L P + V +GS G + Y+ ++PEK +G+ +L N S YP
Sbjct: 311 VALAALPAVEVNPPVPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKS-YP 365
>pir||T19869 hypothetical protein C40H5.4 - Caenorhabditis elegans
>gi|5824403|emb|CAB03955.2| (Z81482) Similarity to
B.subtilis penicillin-binding protein (SW:P32959)
[Caenorhabditis elegans]
Length = 392
Score = 100 bits (246), Expect = 4e-20
Identities = 78/272 (28%), Positives = 127/272 (46%), Gaps = 27/272 (9%)
Query: 14 MAERKVPGISISIIKDGDVVYAKGFGYRNVEARLPSTPETIYGIGSITKSFTALAIMKLV 73
M + +PG+SI+I K + +A GFGY ++ + P TP + +GS++K TA AIM L+
Sbjct: 12 MKDLNIPGLSIAIAKKEQLKFAAGFGYTDIRQQEPVTPNHQFRVGSVSKPVTAAAIMLLI 71
Query: 74 EEGGLSLDDPV---------EKFVNIKLRPFGEPVTVHHLLTHSSGIPSLGYAEAFIDGM 124
++G +LD + E + + +TV HLL H++G G+ D +
Sbjct: 72 DKGHFTLDSKLFGKDSIFGSEFSKKYQYPRYVTEITVRHLLEHTAG----GW-----DNL 122
Query: 125 VGGDNWL-PVSTPEETIAFARDMEKWAVAKPGERFFYLNTGYVLLGKIIEKVSGVSYEEY 183
W+ P T +E I + KPG + Y N GY LLG +IE +G+SYE +
Sbjct: 123 QSDAAWVQPEMTTKELIEYVLTNVPLEY-KPGTMWIYSNFGYQLLGYLIETTTGMSYEAF 181
Query: 184 IKKKILEPLGMNRSYFFKEEVEKDKDVAMGYILDKEGRLVPQPF----PYGITADGGLLS 239
+KK I P G+ + + + + Y + G L P+ P I GG ++
Sbjct: 182 VKKNIFAPSGVYDIQVARPSISERAPREVMYYMSGNG-LGFNPYEMLPPERIGPWGGWIA 240
Query: 240 SVLDLAKYLKMY--IERDESIVSKEYIEKMET 269
S + L ++ E I+S I ++ T
Sbjct: 241 SPIQLLMFMSRIDGFSNREDILSDVAIAELAT 272
>pir||S44094 beta-lactamase (EC 3.5.2.6) - Citrobacter freundii
>gi|472908|emb|CAA54084.1| (X76636) beta-lactamase
[Citrobacter freundii]
Length = 381
Score = 99.8 bits (245), Expect = 5e-20
Identities = 88/359 (24%), Positives = 169/359 (46%), Gaps = 64/359 (17%)
Query: 10 IVEKMAERKVPGISISIIKDGDVVYAKGFGYRNVEARLPSTPETIYGIGSITKSFTALAI 69
I M E+ +PG++++II G Y +G ++ P T +T++ +GS++K+F +
Sbjct: 36 ITPLMKEQAIPGMAVAIIYQGKSYYFT-WGKADIANNRPVTQQTLFELGSVSKTFNGVLG 94
Query: 70 MKLVEEGGLSLDDPVEKFVNIKLRPFGEPVTVHHLLTHSSGIPSLGYAEAFIDGMVGGDN 129
+ G + L+DPV ++ + +++ HL T+++G
Sbjct: 95 GDAIARGEIKLNDPVTRYWPELTGKQWQGISLLHLATYTAG------------------- 135
Query: 130 WLPVSTPEETI---AFARDMEKWAVA-KPGERFFYLNTGYVLLGKIIEKVSGVSYEEYIK 185
LP+ P+E A + W PG + Y N+ L G + K SG+ YEE +
Sbjct: 136 GLPLQIPDEVTDKAALLHFYQNWQPQWAPGAKRLYANSSIGLFGALAVKPSGMGYEEAMI 195
Query: 186 KKILEPLGMNRSYFFKEEVEKDKDVAMGYILDKEGRLVPQPFPYGITADG-GLLSSVLDL 244
+IL+PL + ++ + E+ KD A GY +EG+ V P + A+ G+ SS++D+
Sbjct: 196 NRILQPLKLKHTWITVPQSEQ-KDYAWGY---REGKPV-HVSPGQLDAEAYGVKSSIMDM 250
Query: 245 AKYLKMYIERD--ESIVSKEYIEKMETSYIKVPWEIFGGEGYGYGLIIYP-------NFL 295
A+++++ ++ + ++ IE ++ Y ++ E++ +G G+ ++ +P N
Sbjct: 251 ARWVQVNMDASHVQEKTLQQGIELAQSRYWRI-GEMY--QGLGWEMLNWPVKADIVINGS 307
Query: 296 GEKL---------------------VGHSGSVGMYTGYIGYIPEKKIGVAVLENSSGYP 333
K+ V +GS G + Y+ +IPEK +G+ +L N S YP
Sbjct: 308 DSKIALAALPAVEVNPPAPVVKASWVHKTGSTGGFGSYVAFIPEKNLGIVMLANKS-YP 365
>pir||T36599 probable beta-lactamase - Streptomyces coelicolor
>gi|4808408|emb|CAB42740.1| (AL049826) putative
beta-lactamase [Streptomyces coelicolor A3(2)]
Length = 461
Score = 99.8 bits (245), Expect = 5e-20
Identities = 93/334 (27%), Positives = 149/334 (43%), Gaps = 38/334 (11%)
Query: 10 IVEKMAERKVPGISISIIKDGDVVYAKGFGYR-NVEARLPSTPETIYGIGSITKSFTALA 68
I AE + P + ++++ G V+ G R +V+ P Y IGSITK+FTA+
Sbjct: 20 IAVAQAEGRTPSLVAAVVRGGRAVW---HGARTSVDGHGPDE-NVQYRIGSITKTFTAVL 75
Query: 69 IMKLVEEGGLSLDDPVEKFVNIKLRPFGEPVTVHHLLTHSSGIPSLGYAEAFIDGMVGGD 128
+++L +EG L L DP+EK ++ GE T+ LL HS G+ + A
Sbjct: 76 VLRLRDEGVLDLGDPLEK--HLPGTGAGE-ATIAELLAHSGGLAAESPAP---------- 122
Query: 129 NWLPVSTPEETIAFARDMEKWAVAKP-GERFFYLNTGYVLLGKIIEKVSGVSYEEYIKKK 187
W + A + K + P G R Y N GY LLG ++EK+ G +EE ++++
Sbjct: 123 -WWERTPGSLRPELADVLGKQPLLHPVGRRHHYSNPGYTLLGALVEKLRGAPWEEVLQRE 181
Query: 188 ILEPLGMNRS-------YFFKEEVEKDKDVAMGYILDKEGRLVPQPFPYGITADGGLLSS 240
+L+PL + R+ + V DV + ++ GR+ P G L S+
Sbjct: 182 VLDPLELRRTGTRPSAPHAGGWAVHPWADVMLAEPVEDLGRMAPA---------GQLWST 232
Query: 241 VLDLAKYLKMYIERDESIVSKEYIEKMETSYIKV-PWEIFGGEGYGYGLIIYPNFLGEKL 299
DLA++ D+ ++ + +M ++ G YG GL I G L
Sbjct: 233 TGDLARFAVFLTLGDDRVLGAATVREMRAPAAPAESADVVDGAAYGLGLQIQHRD-GRLL 291
Query: 300 VGHSGSVGMYTGYIGYIPEKKIGVAVLENSSGYP 333
VGHSGS+ + + E + VL N + P
Sbjct: 292 VGHSGSLPGFLANLTIGVEDDVAAVVLTNCTSGP 325
>dbj|BAA02494.1| (D13207) beta-lactamase precursor [Citrobacter freundii]
Length = 381
Score = 99.5 bits (244), Expect = 7e-20
Identities = 88/356 (24%), Positives = 163/356 (45%), Gaps = 58/356 (16%)
Query: 10 IVEKMAERKVPGISISIIKDGDVVYAKGFGYRNVEARLPSTPETIYGIGSITKSFTALAI 69
I M E+ +PG++++II +G Y +G ++ P T +T++ +GS++K+F +
Sbjct: 36 ITPLMQEQAIPGMAVAIIYEGKPYYFT-WGKADIANNHPVTQQTLFELGSVSKTFNGVLG 94
Query: 70 MKLVEEGGLSLDDPVEKFVNIKLRPFGEPVTVHHLLTHSSGIPSLGYAEAFIDGMVGGDN 129
+ G + L DPV K+ +++ HL T+++G
Sbjct: 95 GDAIARGEIKLSDPVTKYWPELTGKQWRGISLLHLATYTAG------------------- 135
Query: 130 WLPVSTPEETI---AFARDMEKWAVA-KPGERFFYLNTGYVLLGKIIEKVSGVSYEEYIK 185
LP+ P++ A R + W PG + Y N+ L G + K SG+SYEE +
Sbjct: 136 GLPLQIPDDITDKAALLRFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMT 195
Query: 186 KKILEPLGMNRSYFFKEEVEKDKDVAMGYILDKEGRLVPQPFPYGITADG-GLLSSVLDL 244
+++L+PL + ++ + E+ K+ A GY +EG+ V P + A+ G+ SSV+D+
Sbjct: 196 RRVLQPLKLAHTWITVPQSEQ-KNYAWGY---REGKPV-HVSPGQLDAEAYGVKSSVIDM 250
Query: 245 AKYLKMYIERD--ESIVSKEYIEKMETSYIKV-------PWE----------IFGGEGYG 285
A++++ ++ + ++ IE ++ Y ++ WE I G
Sbjct: 251 ARWVQANMDASHVQEKTLQQGIELAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSK 310
Query: 286 YGLIIYPNF--------LGEKLVGHSGSVGMYTGYIGYIPEKKIGVAVLENSSGYP 333
L P + V +GS G + Y+ ++PEK +G+ +L N S YP
Sbjct: 311 VALAALPAVEVNPPVPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKS-YP 365
>emb|CAA75401.1| (Y15129) beta lactamase class C [Citrobacter freundii]
Length = 381
Score = 99.5 bits (244), Expect = 7e-20
Identities = 88/356 (24%), Positives = 163/356 (45%), Gaps = 58/356 (16%)
Query: 10 IVEKMAERKVPGISISIIKDGDVVYAKGFGYRNVEARLPSTPETIYGIGSITKSFTALAI 69
I M E+ +PG++++II +G Y +G ++ P T +T++ +GS++K+F +
Sbjct: 36 ITPLMQEQAIPGMAVAIIYEGKPYYFT-WGKADIANNHPVTQQTLFELGSVSKTFNGVLG 94
Query: 70 MKLVEEGGLSLDDPVEKFVNIKLRPFGEPVTVHHLLTHSSGIPSLGYAEAFIDGMVGGDN 129
+ G + L DPV K+ +++ HL T+++G
Sbjct: 95 GDAIARGEIKLSDPVTKYWPELTGKQWRGISLLHLATYTAG------------------- 135
Query: 130 WLPVSTPEETI---AFARDMEKWAVA-KPGERFFYLNTGYVLLGKIIEKVSGVSYEEYIK 185
LP+ P++ A R + W PG + Y N+ L G + K SG+SYEE +
Sbjct: 136 GLPLQIPDDITDKAALLRFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMT 195
Query: 186 KKILEPLGMNRSYFFKEEVEKDKDVAMGYILDKEGRLVPQPFPYGITADG-GLLSSVLDL 244
+++L+PL + ++ + E+ K+ A GY +EG+ V P + A+ G+ SSV+D+
Sbjct: 196 RRVLQPLKLAHTWITVPQSEQ-KNYAWGY---REGKPV-HVSPGQLDAEAYGVKSSVIDM 250
Query: 245 AKYLKMYIERD--ESIVSKEYIEKMETSYIKV-------PWE----------IFGGEGYG 285
A++++ ++ + ++ IE ++ Y ++ WE I G
Sbjct: 251 ARWVQANMDASHVQEKTLQQGIELAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSK 310
Query: 286 YGLIIYPNF--------LGEKLVGHSGSVGMYTGYIGYIPEKKIGVAVLENSSGYP 333
L P + V +GS G + Y+ ++PEK +G+ +L N S YP
Sbjct: 311 VALAALPAVEVNPPVPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKS-YP 365
>dbj|BAA32077.1| (AB016611) ampC [Enterobacter cloacae]
Length = 381
Score = 99.1 bits (243), Expect = 9e-20
Identities = 89/360 (24%), Positives = 163/360 (44%), Gaps = 58/360 (16%)
Query: 6 LESFIVEKMAERKVPGISISIIKDGDVVYAKGFGYRNVEARLPSTPETIYGIGSITKSFT 65
+E + M + +PG+++++I G Y FG +V A P TP+T++ +GSI+K+FT
Sbjct: 32 VERTVTPLMKAQAIPGMAVAVIYQGQPHYFT-FGKADVAANKPVTPQTLFELGSISKTFT 90
Query: 66 ALAIMKLVEEGGLSLDDPVEKFVNIKLRPFGEPVTVHHLLTHSSGIPSLGYAEAFIDGMV 125
+ + G +SL DPV K+ + + + L T+++G
Sbjct: 91 GVLGGDAIARGEISLGDPVTKYWPELTGKQWQGIRMLDLATYTAG--------------- 135
Query: 126 GGDNWLPVSTPEE---TIAFARDMEKWAVA-KPGERFFYLNTGYVLLGKIIEKVSGVSYE 181
LP+ P+E + R + W KPG Y N L G + K SG+S+E
Sbjct: 136 ----GLPLQVPDEVTDNASLLRFYQHWQPQWKPGTTRLYANASIGLFGALAVKPSGMSFE 191
Query: 182 EYIKKKILEPLGMNRSYFFKEEVEKDKDVAMGYILDKEGRLVPQPFPYGITADG-GLLSS 240
+ + K++ +PL ++ ++ E++ A GY ++G+ + P + A+ G+ ++
Sbjct: 192 QAMTKRVFKPLKLDHTW-INVPKEEEAHYAWGY---RDGKAI-HVSPGMLDAEAYGVKTN 246
Query: 241 VLDLAKYLKMYIERD--ESIVSKEYIEKMETSYIKV-------PWEIFGG--------EG 283
+ D+A +LK + D K+ I ++ Y +V WE+ EG
Sbjct: 247 ITDMASWLKANMNPDALPDSTLKQGIALAQSRYWRVGAMYQGLGWEMLNWPVEAKTVVEG 306
Query: 284 YGYGLIIYPNFLGE----------KLVGHSGSVGMYTGYIGYIPEKKIGVAVLENSSGYP 333
+ + P + E + +GS G + Y+ +IPEK++G+ +L N S YP
Sbjct: 307 SDNKVALAPLPVAEVNPPAPPVKASWIHKTGSTGGFGSYVAFIPEKELGIVMLANKS-YP 365
>gb|AAD28042.1|AF124202_1 (AF124202) beta-lactamase precursor [Escherichia coli]
Length = 377
Score = 99.1 bits (243), Expect = 9e-20
Identities = 85/357 (23%), Positives = 163/357 (44%), Gaps = 60/357 (16%)
Query: 10 IVEKMAERKVPGISISIIKDGDVVYAKGFGYRNVEARLPSTPETIYGIGSITKSFTALAI 69
I + ++K+PG+++++I G Y +GY ++ + P T +T++ +GS++K+FT +
Sbjct: 32 ITPLIEQQKIPGMAVAVIYQGKPYYFT-WGYADIAKKQPVTQQTLFELGSVSKTFTGVLG 90
Query: 70 MKLVEEGGLSLDDPVEKFVNIKLRPFGEPVTVHHLLTHSSGIPSLGYAEAFIDGMVGGDN 129
+ G + L DP K+ +T+ HL T+++G
Sbjct: 91 GDAIARGEIKLSDPATKYWPELTAKQWNGITLLHLATYTAG------------------- 131
Query: 130 WLPVSTPEETIA---FARDMEKWAVA-KPGERFFYLNTGYVLLGKIIEKVSGVSYEEYIK 185
LP+ P+E + R + W A PG + Y NT L G + K SG+S+E+ ++
Sbjct: 132 GLPLQVPDEVKSSSDLLRFYQNWQPAWTPGTQRLYANTSIGLFGALAVKPSGLSFEQAMQ 191
Query: 186 KKILEPLGMNRSYFFKEEVEKDKDVAMGYILDKEGRLVPQPFPYGITADG-GLLSSVLDL 244
++ +PL +N ++ E +K+ A GY +EG+ V P + A+ G+ S++ D+
Sbjct: 192 TRVFQPLKLNHTWINVPPAE-EKNYAWGY---REGKAV-HVSPGALDAEAYGVKSTIEDM 246
Query: 245 AKYLKMYIERDESIVSKEYIEKMETS----------YIKVPWE----------IFGGEGY 284
A++++ + + I K + ++ + Y + WE I G
Sbjct: 247 ARWVQSNL-KPLDITEKTLQQGIQLAQSRYWQTGDMYQGLGWEMQDWPVNPDIIINGSDN 305
Query: 285 GYGLIIYP--------NFLGEKLVGHSGSVGMYTGYIGYIPEKKIGVAVLENSSGYP 333
L P + V +G+ G + Y+ +IPEK++G+ +L N + YP
Sbjct: 306 KIALAARPVKAITPPTPAVRASWVHKTGATGGFGSYVAFIPEKELGIVMLANKN-YP 361
>sp|P05193|AMPC_CITFR BETA-LACTAMASE PRECURSOR (CEPHALOSPORINASE) >gi|78235|pir||A24869
beta-lactamase (EC 3.5.2.6) precursor - Citrobacter
freundii >gi|40452|emb|CAA27494.1| (X03866)
beta-lactamase precursor [Citrobacter freundii]
Length = 381
Score = 99.1 bits (243), Expect = 9e-20
Identities = 89/353 (25%), Positives = 167/353 (47%), Gaps = 52/353 (14%)
Query: 10 IVEKMAERKVPGISISIIKDGDVVYAKGFGYRNVEARLPSTPETIYGIGSITKSFTALAI 69
I M E+ +PG++++II +G Y +G ++ P T +T++ +GS++K+F +
Sbjct: 36 ITPLMQEQAIPGMAVAIIYEGKPYYFT-WGKADIANNHPVTQQTLFELGSVSKTFNGVLG 94
Query: 70 MKLVEEGGLSLDDPVEKFVNIKLRPFGEPVTVHHLLTHSSGIPSLGYAEAFIDGMVGGDN 129
+ G + L DPV K+ +++ HL T+++G L + GD
Sbjct: 95 GDRIARGEIKLSDPVTKYWPELTGKQWRGISLLHLATYTAGGLPL---------QIPGD- 144
Query: 130 WLPVSTPEETIAFARDME-KWAVAKPGERFFYLNTGYVLLGKIIEKVSGVSYEEYIKKKI 188
V+ E + F ++ + +W PG + Y N+ L G + K SG+SYEE + +++
Sbjct: 145 ---VTDKAELLRFYQNWQPQWT---PGAKRLYANSSIGLFGALAVKSSGMSYEEAMTRRV 198
Query: 189 LEPLGMNRSYFFKEEVEKDKDVAMGYILDKEGRLVPQPFPYGITADG-GLLSSVLDLAKY 247
L+PL + ++ + E+ K+ A GY+ EG+ V P + A+ G+ SSV+D+A++
Sbjct: 199 LQPLKLAHTWITVPQSEQ-KNYAWGYL---EGKPV-HVSPGQLDAEAYGVKSSVIDMARW 253
Query: 248 LKMYIERD--ESIVSKEYIEKMETSYIKV-------PWE----------IFGGEGYGYGL 288
++ ++ + ++ IE ++ Y ++ WE I G L
Sbjct: 254 VQANMDASHVQEKTLQQGIELAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDSKVAL 313
Query: 289 IIYPNF--------LGEKLVGHSGSVGMYTGYIGYIPEKKIGVAVLENSSGYP 333
P + V +GS G + Y+ ++PEK +G+ +L N S YP
Sbjct: 314 AALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKS-YP 365
>emb|CAB36902.1| (AJ011293) beta-lactamase [Escherichia coli]
Length = 381
Score = 98.3 bits (241), Expect = 2e-19
Identities = 88/358 (24%), Positives = 161/358 (44%), Gaps = 62/358 (17%)
Query: 10 IVEKMAERKVPGISISIIKDGDVVYAKGFGYRNVEARLPSTPETIYGIGSITKSFTALAI 69
I M E+ +PG+++++I G Y +G ++ P T +T++ +GS++K+F +
Sbjct: 36 ITPLMQEQAIPGMAVAVIYQGKPYYFT-WGKADIANNHPVTQQTLFELGSVSKTFNGVLG 94
Query: 70 MKLVEEGGLSLDDPVEKFVNIKLRPFGEPVTVHHLLTHSSGIPSLGYAEAFIDGMVGGDN 129
+ G + L DPV K+ + + + HL T+++G
Sbjct: 95 GDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAG------------------- 135
Query: 130 WLPVSTPEET---IAFARDMEKWAVA-KPGERFFYLNTGYVLLGKIIEKVSGVSYEEYIK 185
LP+ P++ A + W PG + Y N+ L G + K SG+SYEE +
Sbjct: 136 GLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMT 195
Query: 186 KKILEPLGMNRSYFFKEEVEKDKDVAMGYILDKEGRLVPQPFPYGITADG-GLLSSVLDL 244
+++L+PL + ++ + E+ KD A+GY +EG+ V P + A+ G+ SSV+D+
Sbjct: 196 RRVLQPLKLAHTWITVPQNEQ-KDYALGY---REGKPV-HVSPGQLDAEAYGVKSSVIDM 250
Query: 245 AKYLKMYIERDESIVSKEYIE-----------KMETSYIKVPWE----------IFGGEG 283
A++++ D S V ++ ++ ++ Y + WE I G
Sbjct: 251 ARWVQ--ANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSD 308
Query: 284 YGYGLIIYPNF--------LGEKLVGHSGSVGMYTGYIGYIPEKKIGVAVLENSSGYP 333
L P + V +GS G + Y+ ++PEK +G+ +L N S YP
Sbjct: 309 SKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKS-YP 365
>emb|CAA65752.1| (X97039) LAT-2 b-lactamase [Klebsiella pneumoniae]
>gi|1836114|gb|AAB46884.1| (S83226) LAT-2=group 1
beta-lactamase [Klebsiella pneumoniae, trf N5-F, plasmid
pMEL, Peptide Plasmid, 381 aa]
Length = 381
Score = 98.3 bits (241), Expect = 2e-19
Identities = 89/358 (24%), Positives = 160/358 (43%), Gaps = 62/358 (17%)
Query: 10 IVEKMAERKVPGISISIIKDGDVVYAKGFGYRNVEARLPSTPETIYGIGSITKSFTALAI 69
I M E+ +PG+++++I G Y +G ++ P T +T++ +GS++K+F +
Sbjct: 36 ITPLMQEQAIPGMAVAVIYQGKPYYFT-WGKADIANNHPVTQQTLFELGSVSKTFNGVLG 94
Query: 70 MKLVEEGGLSLDDPVEKFVNIKLRPFGEPVTVHHLLTHSSGIPSLGYAEAFIDGMVGGDN 129
+ G + L DPV K+ + + + HL T+++G
Sbjct: 95 GDCIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAG------------------- 135
Query: 130 WLPVSTPEET---IAFARDMEKWAVA-KPGERFFYLNTGYVLLGKIIEKVSGVSYEEYIK 185
LP+ P++ A + W PG + Y N+ L G + K SG+SYEE +
Sbjct: 136 GLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMT 195
Query: 186 KKILEPLGMNRSYFFKEEVEKDKDVAMGYILDKEGRLVPQPFPYGITADG-GLLSSVLDL 244
+++L+PL + ++ E E+ KD A GY +EG+ V P + A+ G+ SSV+D+
Sbjct: 196 RRVLQPLKLAHTWITVPENEQ-KDYAWGY---REGKPV-HVSPGQLDAEAYGVKSSVIDM 250
Query: 245 AKYLKMYIERDESIVSKEYIE-----------KMETSYIKVPWE----------IFGGEG 283
A++++ D S V ++ ++ ++ Y + WE I G
Sbjct: 251 ARWVQ--ANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSD 308
Query: 284 YGYGLIIYPNF--------LGEKLVGHSGSVGMYTGYIGYIPEKKIGVAVLENSSGYP 333
L P + V +GS G + Y+ ++PEK +G+ +L N S YP
Sbjct: 309 SKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKS-YP 365
>emb|CAB36900.1| (AJ011291) beta-lactamase [Escherichia coli]
Length = 381
Score = 97.9 bits (240), Expect = 2e-19
Identities = 88/358 (24%), Positives = 161/358 (44%), Gaps = 62/358 (17%)
Query: 10 IVEKMAERKVPGISISIIKDGDVVYAKGFGYRNVEARLPSTPETIYGIGSITKSFTALAI 69
I M E+ +PG+++++I G Y +G ++ P T +T++ +GS++K+F +
Sbjct: 36 ITPLMQEQAIPGMAVAVIYQGKPYYFT-WGKADIANNHPVTQQTLFELGSVSKTFNGVLG 94
Query: 70 MKLVEEGGLSLDDPVEKFVNIKLRPFGEPVTVHHLLTHSSGIPSLGYAEAFIDGMVGGDN 129
+ G + L DPV K+ + + + HL T+++G
Sbjct: 95 GDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAG------------------- 135
Query: 130 WLPVSTPEET---IAFARDMEKWAVA-KPGERFFYLNTGYVLLGKIIEKVSGVSYEEYIK 185
LP+ P++ A + W PG + Y N+ L G++ K SG+SYEE +
Sbjct: 136 GLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGELAVKPSGMSYEEAMT 195
Query: 186 KKILEPLGMNRSYFFKEEVEKDKDVAMGYILDKEGRLVPQPFPYGITADG-GLLSSVLDL 244
+++L+PL + ++ + E+ KD A GY +EG+ V P + A+ G+ SSV+D+
Sbjct: 196 RRVLQPLKLAHTWITVPQNEQ-KDYAWGY---REGKPV-HVSPGQLDAEAYGVKSSVIDM 250
Query: 245 AKYLKMYIERDESIVSKEYIE-----------KMETSYIKVPWE----------IFGGEG 283
A++++ D S V ++ ++ ++ Y + WE I G
Sbjct: 251 ARWVQ--ANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSD 308
Query: 284 YGYGLIIYPNF--------LGEKLVGHSGSVGMYTGYIGYIPEKKIGVAVLENSSGYP 333
L P + V +GS G + Y+ ++PEK +G+ +L N S YP
Sbjct: 309 SKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKS-YP 365
>emb|CAC08446.1| (AJ278995) class C beta-lactamase [Enterobacter cloacae]
Length = 381
Score = 97.9 bits (240), Expect = 2e-19
Identities = 90/352 (25%), Positives = 160/352 (44%), Gaps = 58/352 (16%)
Query: 14 MAERKVPGISISIIKDGDVVYAKGFGYRNVEARLPSTPETIYGIGSITKSFTALAIMKLV 73
M + +PG+++++I G Y FG ++ A P TP+T++ +GSI+K+FT + +
Sbjct: 40 MKAQSIPGMAVAVIYQGKPHYYT-FGKADIAANKPVTPQTLFELGSISKTFTGVLGGDAI 98
Query: 74 EEGGLSLDDPVEKFVNIKLRPFGEPVTVHHLLTHSSGIPSLGYAEAFIDGMVGGDNWLPV 133
G +SLDDPV ++ + + + L T+++G LP+
Sbjct: 99 ARGEISLDDPVTRYWPQLTGKQWQGIRMLDLATYTAG-------------------GLPL 139
Query: 134 STPEETI---AFARDMEKWAVA-KPGERFFYLNTGYVLLGKIIEKVSGVSYEEYIKKKIL 189
P+E A R + W KPG Y N L G + K SG+ YE+ + ++L
Sbjct: 140 QVPDEVTDNAALLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMGYEQAMTTRVL 199
Query: 190 EPLGMNRSYFFKEEVEKDKDVAMGYILDKEGRLVPQPFPYGITADG-GLLSSVLDLAKYL 248
+PL ++ ++ + E + A GY ++G+ V + P + A G+ ++V D+A ++
Sbjct: 200 KPLKLDHTWINVPKAE-EAHYAWGY---RDGKAV-RVSPGMLDAQAYGVKTNVQDMANWV 254
Query: 249 --KMYIERDESIVSKEYIEKMETSYIKVP-------WEIFGG--------EGYGYGLIIY 291
M E+ K+ I ++ Y ++ WE+ EG + +
Sbjct: 255 MANMAPEKVADASLKQGISLAQSRYWRIGSMYQGLGWEMLNWPVEANTVIEGSDSKVALA 314
Query: 292 PNFLGE----------KLVGHSGSVGMYTGYIGYIPEKKIGVAVLENSSGYP 333
P + E V +GS G + Y+ +IPEK+IG+ +L N S YP
Sbjct: 315 PLPVAEVNPPAPPVEASWVHKTGSTGGFGSYVAFIPEKQIGIVMLANKS-YP 365
>gb|AAD22636.1| (M37839) beta-lactamase [Klebsiella pneumoniae]
Length = 381
Score = 97.5 bits (239), Expect = 3e-19
Identities = 92/360 (25%), Positives = 163/360 (44%), Gaps = 58/360 (16%)
Query: 6 LESFIVEKMAERKVPGISISIIKDGDVVYAKGFGYRNVEARLPSTPETIYGIGSITKSFT 65
+E + M + +PG+++++I G Y FG +V A P TP+T++ +GSI+K+FT
Sbjct: 32 VERTVTPLMNAQAIPGMAVAVIYQGQPHYFT-FGKADVAANKPVTPQTLFELGSISKTFT 90
Query: 66 ALAIMKLVEEGGLSLDDPVEKFVNIKLRPFGEPVTVHHLLTHSSGIPSLGYAEAFIDGMV 125
+ + G ++L DPV K+ + + + L T+++G
Sbjct: 91 GVLGGDAIARGEIALGDPVAKYWPELTGKQWQGIRMLDLATYTAG--------------- 135
Query: 126 GGDNWLPVSTPEE---TIAFARDMEKWAVA-KPGERFFYLNTGYVLLGKIIEKVSGVSYE 181
LP+ P+E T + R + W KPG Y N L G + K SG+SYE
Sbjct: 136 ----GLPLQVPDEVTDTASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYE 191
Query: 182 EYIKKKILEPLGMNRSYFFKEEVEKDKDVAMGYILDKEGRLVPQPFPYGITADG-GLLSS 240
+ + ++ +PL ++ ++ + E + A GY +EG+ V P + A+ G+ ++
Sbjct: 192 QAMTTRVFKPLKLDHTWINVPKAE-EAHFAWGY---REGKAV-HVSPGMLDAEAYGVKTN 246
Query: 241 VLDLAKYLKMYIERD--ESIVSKEYIEKMETSYIKV-------PWE----------IFGG 281
V D+A +L ++ D ++ K+ I ++ Y +V WE + GG
Sbjct: 247 VKDMASWLIANMKPDSLQAPSLKQGIALAQSRYWRVGAMYQGLGWEMLNWPVDAKTVVGG 306
Query: 282 EGYGYGLIIYPNF--------LGEKLVGHSGSVGMYTGYIGYIPEKKIGVAVLENSSGYP 333
L P + V +GS G + Y+ +IPEK++G+ +L N S YP
Sbjct: 307 SDNKVALAPLPVAEVNPPAPPVKASWVHKTGSTGGFGSYVAFIPEKQLGIVMLANKS-YP 365
>pir||S45109 beta-lactamase (EC 3.5.2.6) precursor - Klebsiella pneumoniae
>gi|496633|emb|CAA55007.1| (X78117) beta-lactamase
precursor [Klebsiella pneumoniae]
Length = 381
Score = 97.1 bits (238), Expect = 4e-19
Identities = 88/358 (24%), Positives = 160/358 (44%), Gaps = 62/358 (17%)
Query: 10 IVEKMAERKVPGISISIIKDGDVVYAKGFGYRNVEARLPSTPETIYGIGSITKSFTALAI 69
I M E+ +PG+++++I G Y +G ++ P T +T++ +GS++K+F +
Sbjct: 36 ITPLMQEQAIPGMAVAVIYQGKPYYFT-WGKADIANNHPVTQQTLFELGSVSKTFNGVLG 94
Query: 70 MKLVEEGGLSLDDPVEKFVNIKLRPFGEPVTVHHLLTHSSGIPSLGYAEAFIDGMVGGDN 129
+ G + L DPV K+ + + + HL T+++G
Sbjct: 95 GDCIARGEIKLSDPVTKYWPELTGKKWQGIRLLHLATYTAG------------------- 135
Query: 130 WLPVSTPEET---IAFARDMEKWAVA-KPGERFFYLNTGYVLLGKIIEKVSGVSYEEYIK 185
LP+ P++ A + W PG + Y N+ L G + K SG+SYEE +
Sbjct: 136 GLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMT 195
Query: 186 KKILEPLGMNRSYFFKEEVEKDKDVAMGYILDKEGRLVPQPFPYGITADG-GLLSSVLDL 244
+++L+PL + ++ + E+ KD A GY +EG+ V P + A+ G+ SSV+D+
Sbjct: 196 RRVLQPLKLAHTWITVPQNEQ-KDYAWGY---REGKPV-HVSPGRLDAEAYGVKSSVIDM 250
Query: 245 AKYLKMYIERDESIVSKEYIE-----------KMETSYIKVPWE----------IFGGEG 283
A++++ D S V ++ ++ ++ Y + WE I G
Sbjct: 251 ARWVQ--ANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSD 308
Query: 284 YGYGLIIYPNF--------LGEKLVGHSGSVGMYTGYIGYIPEKKIGVAVLENSSGYP 333
L P + V +GS G + Y+ ++PEK +G+ +L N S YP
Sbjct: 309 SKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKS-YP 365
>emb|CAA62957.1| (X91840) extended spectrum beta-lactamase [Klebsiella pneumoniae]
>gi|2959388|emb|CAA76381.1| (Y16784) beta-lactamase
class C [Klebsiella pneumoniae]
Length = 381
Score = 97.1 bits (238), Expect = 4e-19
Identities = 88/358 (24%), Positives = 160/358 (44%), Gaps = 62/358 (17%)
Query: 10 IVEKMAERKVPGISISIIKDGDVVYAKGFGYRNVEARLPSTPETIYGIGSITKSFTALAI 69
I M E+ +PG+++++I G Y +G ++ P T +T++ +GS++K+F +
Sbjct: 36 ITPLMQEQAIPGMAVAVIYQGKPYYFT-WGKADIANNHPVTQQTLFELGSVSKTFNGVLG 94
Query: 70 MKLVEEGGLSLDDPVEKFVNIKLRPFGEPVTVHHLLTHSSGIPSLGYAEAFIDGMVGGDN 129
+ G + L DPV K+ + + + HL T+++G
Sbjct: 95 GDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAG------------------- 135
Query: 130 WLPVSTPEET---IAFARDMEKWAVA-KPGERFFYLNTGYVLLGKIIEKVSGVSYEEYIK 185
LP+ P++ A + W PG + Y N+ L G + K SG+SYEE +
Sbjct: 136 GLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMT 195
Query: 186 KKILEPLGMNRSYFFKEEVEKDKDVAMGYILDKEGRLVPQPFPYGITADG-GLLSSVLDL 244
+++L+PL + ++ + E+ KD A GY +EG+ V P + A+ G+ SSV+D+
Sbjct: 196 RRVLQPLKLAHTWITVPQNEQ-KDYAWGY---REGKPV-HVSPGQLDAEAYGVKSSVIDM 250
Query: 245 AKYLKMYIERDESIVSKEYIE-----------KMETSYIKVPWE----------IFGGEG 283
A++++ D S V ++ ++ ++ Y + WE I G
Sbjct: 251 ARWVQ--ANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSD 308
Query: 284 YGYGLIIYPNF--------LGEKLVGHSGSVGMYTGYIGYIPEKKIGVAVLENSSGYP 333
L P + V +GS G + Y+ ++PEK +G+ +L N S YP
Sbjct: 309 SKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKS-YP 365
>gb|AAB80855.1| (U77414) bla LAT-3 [Salmonella senftenberg]
Length = 381
Score = 97.1 bits (238), Expect = 4e-19
Identities = 88/358 (24%), Positives = 160/358 (44%), Gaps = 62/358 (17%)
Query: 10 IVEKMAERKVPGISISIIKDGDVVYAKGFGYRNVEARLPSTPETIYGIGSITKSFTALAI 69
I M E+ +PG+++++I G Y +G ++ P T +T++ +GS++K+F +
Sbjct: 36 ITPLMQEQAIPGMAVAVIYQGKPYYFT-WGKADIANNHPVTQQTLFELGSVSKTFNGVLG 94
Query: 70 MKLVEEGGLSLDDPVEKFVNIKLRPFGEPVTVHHLLTHSSGIPSLGYAEAFIDGMVGGDN 129
+ G + L DPV K+ + + + HL T+++G
Sbjct: 95 GDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAG------------------- 135
Query: 130 WLPVSTPEET---IAFARDMEKWAVA-KPGERFFYLNTGYVLLGKIIEKVSGVSYEEYIK 185
LP+ P++ A + W PG + Y N+ L G + K SG+SYEE +
Sbjct: 136 GLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMT 195
Query: 186 KKILEPLGMNRSYFFKEEVEKDKDVAMGYILDKEGRLVPQPFPYGITADG-GLLSSVLDL 244
+++L+PL + ++ + E+ KD A GY +EG+ V P + A+ G+ SSV+D+
Sbjct: 196 RRVLQPLKLAHTWITVPQNEQ-KDYAWGY---REGKPV-HVSPGQLDAEAYGVKSSVIDM 250
Query: 245 AKYLKMYIERDESIVSKEYIE-----------KMETSYIKVPWE----------IFGGEG 283
A++++ D S V ++ ++ ++ Y + WE I G
Sbjct: 251 ARWVQ--ANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSD 308
Query: 284 YGYGLIIYPNF--------LGEKLVGHSGSVGMYTGYIGYIPEKKIGVAVLENSSGYP 333
L P + V +GS G + Y+ ++PEK +G+ +L N S YP
Sbjct: 309 SKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKS-YP 365
>emb|CAA75402.1| (Y15130) beta-lactamase class C [Proteus mirabilis]
>gi|2959382|emb|CAA76378.1| (Y16781) beta-lactamase
class C [Klebsiella pneumoniae]
>gi|2959384|emb|CAA76379.1| (Y16782) beta-lactamase
class C [Proteus mirabilis] >gi|2959386|emb|CAA76380.1|
(Y16783) beta-lactamase class C [Proteus mirabilis]
>gi|3334640|emb|CAA07695.1| (AJ007826) class C
beta-lactamase [Escherichia coli]
Length = 381
Score = 97.1 bits (238), Expect = 4e-19
Identities = 88/358 (24%), Positives = 160/358 (44%), Gaps = 62/358 (17%)
Query: 10 IVEKMAERKVPGISISIIKDGDVVYAKGFGYRNVEARLPSTPETIYGIGSITKSFTALAI 69
I M E+ +PG+++++I G Y +G ++ P T +T++ +GS++K+F +
Sbjct: 36 ITPLMQEQAIPGMAVAVIYQGKPYYFT-WGKADIANNHPVTQQTLFELGSVSKTFNGVLG 94
Query: 70 MKLVEEGGLSLDDPVEKFVNIKLRPFGEPVTVHHLLTHSSGIPSLGYAEAFIDGMVGGDN 129
+ G + L DPV K+ + + + HL T+++G
Sbjct: 95 GDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAG------------------- 135
Query: 130 WLPVSTPEET---IAFARDMEKWAVA-KPGERFFYLNTGYVLLGKIIEKVSGVSYEEYIK 185
LP+ P++ A + W PG + Y N+ L G + K SG+SYEE +
Sbjct: 136 GLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMT 195
Query: 186 KKILEPLGMNRSYFFKEEVEKDKDVAMGYILDKEGRLVPQPFPYGITADG-GLLSSVLDL 244
+++L+PL + ++ + E+ KD A GY +EG+ V P + A+ G+ SSV+D+
Sbjct: 196 RRVLQPLKLAHTWITVPQNEQ-KDYARGY---REGKPV-HVSPGQLDAEAYGVKSSVIDM 250
Query: 245 AKYLKMYIERDESIVSKEYIE-----------KMETSYIKVPWE----------IFGGEG 283
A++++ D S V ++ ++ ++ Y + WE I G
Sbjct: 251 ARWVQ--ANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSD 308
Query: 284 YGYGLIIYPNF--------LGEKLVGHSGSVGMYTGYIGYIPEKKIGVAVLENSSGYP 333
L P + V +GS G + Y+ ++PEK +G+ +L N S YP
Sbjct: 309 SKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKS-YP 365
>emb|CAA75610.1| (Y15411) beta-lactamase LAT-3 protein [Escherichia coli]
Length = 381
Score = 97.1 bits (238), Expect = 4e-19
Identities = 90/357 (25%), Positives = 161/357 (44%), Gaps = 60/357 (16%)
Query: 10 IVEKMAERKVPGISISIIKDGDVVYAKGFGYRNVEARLPSTPETIYGIGSITKSFTALAI 69
I M E+ +PG+++++I G Y +G ++ P T +T++ +GS++K+F +
Sbjct: 36 ITPLMQEQAIPGMAVAVIYQGKPYYFT-WGKADIANNHPVTQQTLFELGSVSKTFNGVLG 94
Query: 70 MKLVEEGGLSLDDPVEKFVNIKLRPFGEPVTVHHLLTHSSGIPSLGYAEAFIDGMV---G 126
+ G + L DPV K+ + + + HL T+++G L + D
Sbjct: 95 GDCMARGEIKLSDPVTKYWPELTGKEWQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHF 154
Query: 127 GDNWLPVSTPEETIAFARDMEKWAVAKPGERFFYLNTGYVLLGKIIEKVSGVSYEEYIKK 186
NWLP +W PG + Y N+ L G + K SG+SYEE + +
Sbjct: 155 YQNWLP---------------QWT---PGAKRLYANSSIGLFGALAVKPSGMSYEEAMTR 196
Query: 187 KILEPLGMNRSYFFKEEVEKDKDVAMGYILDKEGRLVPQPFPYGITADG-GLLSSVLDLA 245
++L+PL + ++ + E+ KD A+GY +EG+ V P + A+ G+ SSV+D+A
Sbjct: 197 RVLQPLKLAHTWITVPQNEQ-KDYALGY---REGKPV-HVSPGRLDAEAYGVKSSVIDMA 251
Query: 246 KYLKMYIERDESIVSKEYIE-----------KMETSYIKVPWE----------IFGGEGY 284
++++ D S V ++ ++ ++ Y + WE I G
Sbjct: 252 RWVQ--ANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSDS 309
Query: 285 GYGLIIYPNF--------LGEKLVGHSGSVGMYTGYIGYIPEKKIGVAVLENSSGYP 333
L P + V +GS G + Y+ ++PEK +G+ +L N S YP
Sbjct: 310 KVALAALPAVEVNPPAPAVKASWVHKTGSSGGFGSYVAFVPEKNLGIVMLANKS-YP 365
>pdb|1C3B|A Chain A, Ampc Beta-Lactamase From E. Coli Complexed With Inhibitor,
Benzo(B)thiophene-2-Boronic Acid (Bzb)
>gi|6573396|pdb|1C3B|B Chain B, Ampc Beta-Lactamase From
E. Coli Complexed With Inhibitor,
Benzo(B)thiophene-2-Boronic Acid (Bzb)
>gi|3660293|pdb|2BLS|A Chain A, Ampc Beta-Lactamase From
Escherichia Coli >gi|3660294|pdb|2BLS|B Chain B, Ampc
Beta-Lactamase From Escherichia Coli
>gi|3660385|pdb|3BLS|A Chain A, Ampc Beta-Lactamase From
Escherichia Coli >gi|3660386|pdb|3BLS|B Chain B, Ampc
Beta-Lactamase From Escherichia Coli
Length = 358
Score = 97.1 bits (238), Expect = 4e-19
Identities = 83/357 (23%), Positives = 162/357 (45%), Gaps = 60/357 (16%)
Query: 10 IVEKMAERKVPGISISIIKDGDVVYAKGFGYRNVEARLPSTPETIYGIGSITKSFTALAI 69
I + ++K+PG+++++I G Y +GY ++ + P T +T++ +GS++K+FT +
Sbjct: 13 ITPLIEQQKIPGMAVAVIYQGKPYYFT-WGYADIAKKQPVTQQTLFELGSVSKTFTGVLG 71
Query: 70 MKLVEEGGLSLDDPVEKFVNIKLRPFGEPVTVHHLLTHSSGIPSLGYAEAFIDGMVGGDN 129
+ G + L DP K+ +T+ HL T+++G
Sbjct: 72 GDAIARGEIKLSDPTTKYWPELTAKQWNGITLLHLATYTAG------------------- 112
Query: 130 WLPVSTPEETIA---FARDMEKWAVA-KPGERFFYLNTGYVLLGKIIEKVSGVSYEEYIK 185
LP+ P+E + R + W A PG + Y N+ L G + K SG+S+E+ ++
Sbjct: 113 GLPLQVPDEVKSSSDLLRFYQNWQPAWAPGTQRLYANSSIGLFGALAVKPSGLSFEQAMQ 172
Query: 186 KKILEPLGMNRSYFFKEEVEKDKDVAMGYILDKEGRLVPQPFPYGITADG-GLLSSVLDL 244
++ +PL +N ++ E +K+ A GY +EG+ V P + A+ G+ S++ D+
Sbjct: 173 TRVFQPLKLNHTWINVPPAE-EKNYAWGY---REGKAV-HVSPGALDAEAYGVKSTIEDM 227
Query: 245 AKYL----------KMYIERDESIVSKEYIEKMETSYIKVPWE----------IFGGEGY 284
A+++ + +++ + Y + + Y + WE I G
Sbjct: 228 ARWVQSNLKPLDINEKTLQQGIQLAQSRYWQTGD-MYQGLGWEMLDWPVNPDSIINGSDN 286
Query: 285 GYGLIIYP--------NFLGEKLVGHSGSVGMYTGYIGYIPEKKIGVAVLENSSGYP 333
L P + V +G+ G + Y+ +IPEK++G+ +L N + YP
Sbjct: 287 KIALAARPVKAITPPTPAVRASWVHKTGATGGFGSYVAFIPEKELGIVMLANKN-YP 342
>sp|P00811|AMPC_ECOLI BETA-LACTAMASE PRECURSOR (CEPHALOSPORINASE) >gi|67775|pir||QKEC
beta-lactamase (EC 3.5.2.6) precursor - Escherichia coli
>gi|145267|gb|AAA23441.1| (J01611) beta-lactamase
[Escherichia coli] >gi|536994|gb|AAA97049.1| (U14003)
beta-lactamase [Escherichia coli]
>gi|1790593|gb|AAC77110.1| (AE000487) beta-lactamase;
penicillin resistance [Escherichia coli K12]
Length = 377
Score = 97.1 bits (238), Expect = 4e-19
Identities = 83/357 (23%), Positives = 162/357 (45%), Gaps = 60/357 (16%)
Query: 10 IVEKMAERKVPGISISIIKDGDVVYAKGFGYRNVEARLPSTPETIYGIGSITKSFTALAI 69
I + ++K+PG+++++I G Y +GY ++ + P T +T++ +GS++K+FT +
Sbjct: 32 ITPLIEQQKIPGMAVAVIYQGKPYYFT-WGYADIAKKQPVTQQTLFELGSVSKTFTGVLG 90
Query: 70 MKLVEEGGLSLDDPVEKFVNIKLRPFGEPVTVHHLLTHSSGIPSLGYAEAFIDGMVGGDN 129
+ G + L DP K+ +T+ HL T+++G
Sbjct: 91 GDAIARGEIKLSDPTTKYWPELTAKQWNGITLLHLATYTAG------------------- 131
Query: 130 WLPVSTPEETIA---FARDMEKWAVA-KPGERFFYLNTGYVLLGKIIEKVSGVSYEEYIK 185
LP+ P+E + R + W A PG + Y N+ L G + K SG+S+E+ ++
Sbjct: 132 GLPLQVPDEVKSSSDLLRFYQNWQPAWAPGTQRLYANSSIGLFGALAVKPSGLSFEQAMQ 191
Query: 186 KKILEPLGMNRSYFFKEEVEKDKDVAMGYILDKEGRLVPQPFPYGITADG-GLLSSVLDL 244
++ +PL +N ++ E +K+ A GY +EG+ V P + A+ G+ S++ D+
Sbjct: 192 TRVFQPLKLNHTWINVPPAE-EKNYAWGY---REGKAV-HVSPGALDAEAYGVKSTIEDM 246
Query: 245 AKYL----------KMYIERDESIVSKEYIEKMETSYIKVPWE----------IFGGEGY 284
A+++ + +++ + Y + + Y + WE I G
Sbjct: 247 ARWVQSNLKPLDINEKTLQQGIQLAQSRYWQTGD-MYQGLGWEMLDWPVNPDSIINGSDN 305
Query: 285 GYGLIIYP--------NFLGEKLVGHSGSVGMYTGYIGYIPEKKIGVAVLENSSGYP 333
L P + V +G+ G + Y+ +IPEK++G+ +L N + YP
Sbjct: 306 KIALAARPVKAITPPTPAVRASWVHKTGATGGFGSYVAFIPEKELGIVMLANKN-YP 361
>dbj|BAA12916.1| (D85910) beta-lactamase [Citrobacter freundii]
Length = 381
Score = 96.7 bits (237), Expect = 5e-19
Identities = 88/358 (24%), Positives = 160/358 (44%), Gaps = 62/358 (17%)
Query: 10 IVEKMAERKVPGISISIIKDGDVVYAKGFGYRNVEARLPSTPETIYGIGSITKSFTALAI 69
I M E+ +PG++++II G Y +G ++ P T +T++ +GS++K+F +
Sbjct: 36 ITPLMQEQAIPGMAVAIIYQGKPYYFT-WGKADIANNRPVTQQTLFELGSVSKTFNGVLG 94
Query: 70 MKLVEEGGLSLDDPVEKFVNIKLRPFGEPVTVHHLLTHSSGIPSLGYAEAFIDGMVGGDN 129
+ G + L DPV ++ + +++ HL T+++G
Sbjct: 95 GDAIARGEIKLSDPVTQYWPELTGKQWQGISLLHLATYTAG------------------- 135
Query: 130 WLPVSTPEETI---AFARDMEKWAVA-KPGERFFYLNTGYVLLGKIIEKVSGVSYEEYIK 185
LP+ P++ A R + W PG + Y N+ L G + K SG+SYEE +
Sbjct: 136 GLPLQVPDDVTDKAALLRFYQNWQPQWAPGAKRLYANSSIGLFGALAVKPSGMSYEEAMT 195
Query: 186 KKILEPLGMNRSYFFKEEVEKDKDVAMGYILDKEGRLVPQPFPYGITADG-GLLSSVLDL 244
++L+PL + ++ + E+ KD A GY +EG+ V P + A+ G+ SSV+D+
Sbjct: 196 TRVLQPLKLAHTWITVPQSEQ-KDYAWGY---REGKPV-HVSPGQLDAEAYGVKSSVVDM 250
Query: 245 AKYLKMYIERDESIVSKEYIE-----------KMETSYIKVPWE----------IFGGEG 283
++++ D S V ++ ++ ++ Y + WE I G
Sbjct: 251 TRWVQ--ANMDASQVQEKTLQQGIKLAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSD 308
Query: 284 YGYGLIIYPNF--------LGEKLVGHSGSVGMYTGYIGYIPEKKIGVAVLENSSGYP 333
L P + V +GS G + Y+ ++PEK +G+ +L N S YP
Sbjct: 309 SKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKS-YP 365
>dbj|BAA94704.1| (AB026907) D-Amino acid amidase [Ochrobactrum anthropi]
Length = 363
Score = 96.7 bits (237), Expect = 5e-19
Identities = 85/339 (25%), Positives = 152/339 (44%), Gaps = 34/339 (10%)
Query: 10 IVEKMAERKVPGISISIIKDGDVVYAKGFGYRNVEARLPSTPETIYGIGSITKSFTALAI 69
I++ R V G+S+++ G+ GY + ++P T + ++ I S TKSF A +
Sbjct: 11 ILDDHVARGVVGVSLALCLPGEETSLYQSGYADKFNKMPMTGDHLFRIASCTKSFIATGL 70
Query: 70 MKLVEEGGLSLDDPVEKFVNIKLRPFGEPVTVHHLLTHSSGIPSLGYAEAFIDGMVGGDN 129
LV++G + LD+P+ ++ + PV + LL H SG+P + M+ +
Sbjct: 71 HLLVQDGTVDLDEPITRWFPDLPKAAQMPVRI--LLNHRSGLPDFETSMP----MISDKS 124
Query: 130 WLPVSTPEETIAFARDMEKWAVAKPGERFFYLNTGYVLLGKIIEKVSGVSYEEYIKKKIL 189
W T +E + F+ +P Y NTGYVL G II +G Y ++++ +I
Sbjct: 125 W----TAQEIVDFS--FRHGVQKEPWHGMEYSNTGYVLAGMIIAHETGKPYSDHLRSRIF 178
Query: 190 EPLGMNRSYFFKEEVEKDKDVAMGYI----------LDKEGRLVP--------QPFPY-G 230
PLGM ++ E + A GY+ D G P + FP G
Sbjct: 179 APLGMKDTWVGTHETFPIEREARGYMHAAADDENPQWDVSGAGDPVDGVWDSTEWFPLSG 238
Query: 231 ITADGGLLSSVLDLAKYLKMYIERDESIVSKEYIEKMETSYIKVPWEIFGGEGYGYGLII 290
A G ++S+ D+ K+L D I+ ++ + +M+ + + G+GL++
Sbjct: 239 ANAAGDMVSTPRDIVKFLNALF--DGRILDQKRLWEMKDNIKPAFFPGSNTVANGHGLLL 296
Query: 291 YPNFLGEKLVGHSGSVGMYTGYIGYIPEKKIGVAVLENS 329
+ +L GH G + +T +G E + +++NS
Sbjct: 297 M-RYGSSELKGHLGQIPGHTSIMGRDEETGAALMLIQNS 334
>emb|CAA75611.1| (Y15412) beta-lactamase LAT-4 protein [Escherichia coli]
Length = 381
Score = 96.3 bits (236), Expect = 6e-19
Identities = 88/358 (24%), Positives = 160/358 (44%), Gaps = 62/358 (17%)
Query: 10 IVEKMAERKVPGISISIIKDGDVVYAKGFGYRNVEARLPSTPETIYGIGSITKSFTALAI 69
I M E+ +PG+++++I G Y +G ++ P T +T++ +GS++K+F +
Sbjct: 36 ITPLMQEQAIPGMAVAVIYQGKPYYFT-WGKADIANNHPVTQQTLFELGSVSKTFNGVLG 94
Query: 70 MKLVEEGGLSLDDPVEKFVNIKLRPFGEPVTVHHLLTHSSGIPSLGYAEAFIDGMVGGDN 129
+ G + L DPV K+ + + + HL T+++G
Sbjct: 95 GDCIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAG------------------- 135
Query: 130 WLPVSTPEET---IAFARDMEKWAVA-KPGERFFYLNTGYVLLGKIIEKVSGVSYEEYIK 185
LP+ P++ A + W PG + Y N+ L G + K SG+SYEE +
Sbjct: 136 GLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMT 195
Query: 186 KKILEPLGMNRSYFFKEEVEKDKDVAMGYILDKEGRLVPQPFPYGITADG-GLLSSVLDL 244
+++L+PL + ++ + E+ KD A GY +EG+ V P + A+ G+ SSV+D+
Sbjct: 196 RRVLQPLKLAHTWITVPQNEQ-KDYAWGY---REGKPV-HVSPGRLDAEAYGVKSSVIDM 250
Query: 245 AKYLKMYIERDESIVSKEYIE-----------KMETSYIKVPWE----------IFGGEG 283
A++++ D S V ++ ++ ++ Y + WE I G
Sbjct: 251 ARWVQ--ANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSD 308
Query: 284 YGYGLIIYPNF--------LGEKLVGHSGSVGMYTGYIGYIPEKKIGVAVLENSSGYP 333
L P + V +GS G + Y+ ++PEK +G+ +L N S YP
Sbjct: 309 SKVALAALPAVEVNPPAPAVKASWVHKTGSSGGFGSYVAFVPEKNLGIVMLANKS-YP 365
>emb|CAC08444.1| (AJ278994) class C beta-lactamase [Enterobacter cloacae]
Length = 375
Score = 96.3 bits (236), Expect = 6e-19
Identities = 91/350 (26%), Positives = 161/350 (46%), Gaps = 60/350 (17%)
Query: 14 MAERKVPGISISIIKDGDVVYAKGFGYRNVEARLPSTPETIYGIGSITKSFTALAIMKLV 73
M + VPG+++++I G Y FG ++ A P TP+T++ +GSI+K+FT + +
Sbjct: 40 MKAQSVPGMAVAVIYQGKPHYYT-FGKADIAANKPVTPQTLFELGSISKTFTGVLGGDAI 98
Query: 74 EEGGLSLDDPVEKFVNIKLRPFGEPVTVHHLLTHSSGIPSLGYAEAFIDGMVGGDNWLPV 133
G +SLDDPV ++ + + + L T+++G LP+
Sbjct: 99 ARGEISLDDPVTRYWPQLTGKQWQGIRMLDLATYTAG-------------------GLPL 139
Query: 134 STPEE---TIAFARDMEKWAVA-KPGERFFYLNTGYVLLGKIIEKVSGVSYEEYIKKKIL 189
P+E + R + W KPG Y N L G + K SG+ YE+ + ++L
Sbjct: 140 QVPDEVTDNASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMPYEQAMTTRVL 199
Query: 190 EPLGMNRSYFFKEEVEKDKDVAMGYILDKEGRLVPQPFPYGITADG-GLLSSVLDLAKYL 248
+PL ++ ++ + E + A GY ++G+ V + P + A G+ ++V D+A ++
Sbjct: 200 KPLKLDHTWINVPKAE-EAHYAWGY---RDGKAV-RVSPGMLDAQAYGVKTNVQDMANWV 254
Query: 249 --KMYIERDESIVSKEYIEKMETSYIKVPWEIFG-GEGYGYGLIIYP---NFLGE----- 297
M E K+ I ++ Y W I +G G+ ++ +P N + E
Sbjct: 255 MANMAPENVADASLKQGIALAQSRY----WRIGSMYQGLGWEMLNWPVEANTVVEGSDPL 310
Query: 298 --------------KLVGHSGSVGMYTGYIGYIPEKKIGVAVLENSSGYP 333
V +GS G + Y+ +IPEK+IG+ +L N+S YP
Sbjct: 311 PVVEVNPPAPPVKASWVHKTGSTGGFGSYVAFIPEKQIGIVMLANTS-YP 359
>emb|CAA30879.1| (X08082) beta-lactamase precursor [Enterobacter cloacae]
Length = 381
Score = 96.3 bits (236), Expect = 6e-19
Identities = 90/352 (25%), Positives = 160/352 (44%), Gaps = 58/352 (16%)
Query: 14 MAERKVPGISISIIKDGDVVYAKGFGYRNVEARLPSTPETIYGIGSITKSFTALAIMKLV 73
M + VPG+++++I G Y FG ++ A P TP+T++ +GSI+K+FT + +
Sbjct: 40 MKAQSVPGMAVAVIYQGKSHYYT-FGKADIAANKPVTPQTLFELGSISKTFTGVLGGDAI 98
Query: 74 EEGGLSLDDPVEKFVNIKLRPFGEPVTVHHLLTHSSGIPSLGYAEAFIDGMVGGDNWLPV 133
G +SLDDPV ++ + + + L T+++G LP+
Sbjct: 99 ARGEISLDDPVTRYWPQLTGKQWQGIRMLDLATYTAG-------------------GLPL 139
Query: 134 STPEETI---AFARDMEKWAVA-KPGERFFYLNTGYVLLGKIIEKVSGVSYEEYIKKKIL 189
P+E + R + W KPG Y N L G + K SG+ YE+ + ++L
Sbjct: 140 QVPDEVTDNASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMPYEQAMTTRVL 199
Query: 190 EPLGMNRSYFFKEEVEKDKDVAMGYILDKEGRLVPQPFPYGITADG-GLLSSVLDLAKYL 248
+PL ++ ++ + E + A GY ++G+ V + P + A G+ ++V D+A ++
Sbjct: 200 KPLKLDHTWINVPKAE-EAHYAWGY---RDGKAV-RVSPGMLDAQAYGVKTNVQDMANWV 254
Query: 249 --KMYIERDESIVSKEYIEKMETSYIKVP-------WEIFGG--------EGYGYGLIIY 291
M E+ K+ I ++ Y ++ WE+ EG + +
Sbjct: 255 MANMAPEKVADASLKQGIALAQSRYWRIGSMYQGLGWEMLNWPVEANTVVEGSDSKVALA 314
Query: 292 PNFLGE----------KLVGHSGSVGMYTGYIGYIPEKKIGVAVLENSSGYP 333
P + E V +GS G + Y+ +IPEK+IG+ +L N S YP
Sbjct: 315 PLPVAEVNPPAPPVKASWVHKTGSTGGFGSYVAFIPEKQIGIVMLANKS-YP 365
>pir||PNKBM beta-lactamase (EC 3.5.2.6) precursor - Enterobacter cloacae
(strain MNH1)
Length = 381
Score = 96.3 bits (236), Expect = 6e-19
Identities = 90/352 (25%), Positives = 160/352 (44%), Gaps = 58/352 (16%)
Query: 14 MAERKVPGISISIIKDGDVVYAKGFGYRNVEARLPSTPETIYGIGSITKSFTALAIMKLV 73
M + VPG+++++I G Y FG ++ A P TP+T++ +GSI+K+FT + +
Sbjct: 40 MKAQSVPGMAVAVIYQGKSHYYT-FGKADIAANKPVTPQTLFELGSISKTFTGVLGGDAI 98
Query: 74 EEGGLSLDDPVEKFVNIKLRPFGEPVTVHHLLTHSSGIPSLGYAEAFIDGMVGGDNWLPV 133
G +SLDDPV ++ + + + L T+++G LP+
Sbjct: 99 ARGEISLDDPVTRYWPQLTGKQWQGIRMLDLATYTAG-------------------GLPL 139
Query: 134 STPEETI---AFARDMEKWAVA-KPGERFFYLNTGYVLLGKIIEKVSGVSYEEYIKKKIL 189
P+E + R + W KPG Y N L G + K SG+ YE+ + ++L
Sbjct: 140 QVPDEVTDNASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMPYEQAMTTRVL 199
Query: 190 EPLGMNRSYFFKEEVEKDKDVAMGYILDKEGRLVPQPFPYGITADG-GLLSSVLDLAKYL 248
+PL ++ ++ + E + A GY ++G+ V + P + A G+ ++V D+A ++
Sbjct: 200 KPLKLDHTWINVPKAE-EAHYAWGY---RDGKAV-RVSPGMLDAQAYGVKTNVQDMANWV 254
Query: 249 --KMYIERDESIVSKEYIEKMETSYIKVP-------WEIFGG--------EGYGYGLIIY 291
M E+ K+ I ++ Y ++ WE+ EG + +
Sbjct: 255 MANMAPEKVADASLKQGIALAQSRYWRIGSMYQGLGWEMLNWPVEANTVVEGSDSKVALA 314
Query: 292 PNFLGE----------KLVGHSGSVGMYTGYIGYIPEKKIGVAVLENSSGYP 333
P + E V +GS G + Y+ +IPEK+IG+ +L N S YP
Sbjct: 315 PLPVAEVNPPAPPVKASWVHKTGSTGGFGSYVAFIPEKQIGIVMLANKS-YP 365
>gb|AAC45086.2| (U58495) beta-lactamase ACT-1 [Klebsiella pneumoniae]
Length = 381
Score = 96.3 bits (236), Expect = 6e-19
Identities = 89/360 (24%), Positives = 165/360 (45%), Gaps = 58/360 (16%)
Query: 6 LESFIVEKMAERKVPGISISIIKDGDVVYAKGFGYRNVEARLPSTPETIYGIGSITKSFT 65
+E + M + +PG+++++I +G Y FG +V A P TP+T++ +GSI+K+FT
Sbjct: 33 VERTVTPLMKAQAIPGMAVAVIYEGQPHYFT-FGKADVAANKPVTPQTLFELGSISKTFT 91
Query: 66 ALAIMKLVEEGGLSLDDPVEKFVNIKLRPFGEPVTVHHLLTHSSGIPSLGYAEAFIDGMV 125
+ + G +SL DPV K+ + + + L T+++G
Sbjct: 92 GVLGGDAIARGEISLGDPVTKYWPELTGKQWQGIRMLDLATYTAG--------------- 136
Query: 126 GGDNWLPVSTPEE---TIAFARDMEKWAVA-KPGERFFYLNTGYVLLGKIIEKVSGVSYE 181
LP+ P+E + R + W KPG Y N L G + K SG+SYE
Sbjct: 137 ----GLPLQVPDEVKDNASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMSYE 192
Query: 182 EYIKKKILEPLGMNRSYFFKEEVEKDKDVAMGYILDKEGRLVPQPFPYGITADG-GLLSS 240
+ I ++ +PL ++ ++ + E + A GY ++G+ V P + A+ G+ ++
Sbjct: 193 QAITTRVFKPLKLDHTWINVPKAE-EAHYAWGY---RDGKAV-HVSPGMLDAEAYGVKTN 247
Query: 241 VLDLAKYLKMYIE----RDESI-----VSKEYIEKMETSYIKVPWEIFGG--------EG 283
V D+A ++ + ++ +D S+ +++ ++ Y + WE+ EG
Sbjct: 248 VQDMASWVMVNMKPDSLQDNSLRKGLTLAQSRYWRVGAMYQGLGWEMLNWPVDAKTVVEG 307
Query: 284 YGYGLIIYPNFLGE----------KLVGHSGSVGMYTGYIGYIPEKKIGVAVLENSSGYP 333
+ + P E V +GS G + Y+ +IPEK++G+ +L N S YP
Sbjct: 308 SDNKVALAPLPAREVNPPAPPVNASWVHKTGSTGGFGSYVAFIPEKQLGIVMLANKS-YP 366
>dbj|BAA07922.1| (D44479) class C beta-lactamase precursor [Enterobacter cloacae]
Length = 384
Score = 96.0 bits (235), Expect = 8e-19
Identities = 91/352 (25%), Positives = 158/352 (44%), Gaps = 55/352 (15%)
Query: 14 MAERKVPGISISIIKDGDVVYAKGFGYRNVEARLPSTPETIYGIGSITKSFTALAIMKLV 73
M + VPG+++++I G Y FG ++ A P TP+T++ +GSI+K+FT + +
Sbjct: 40 MKAQSVPGMAVAVIYQGKPHYYT-FGKADIAANKPVTPQTLFELGSISKTFTGVLGGDAI 98
Query: 74 EEGGLSLDDPVEKFVNIKLRPFGEPVTVHHLLTHSSGIPSLGYAEAFIDGMVGGDNWLPV 133
G +SLDDPV ++ + + + L T+++G LP+
Sbjct: 99 ARGEISLDDPVTRYWPQLTGKQWQGIRMLDLATYTAG-------------------GLPL 139
Query: 134 STPEE---TIAFARDMEKWAVA-KPGERFFYLNTGYVLLGKIIEKVSGVSYEEYIKKKIL 189
P+E + R + W KPG Y N L G + K SG+ YE+ + ++L
Sbjct: 140 QVPDEVTDNASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMPYEQAMTTRVL 199
Query: 190 EPLGMNRSYFFKEEVEKDKDVAMGYILDKEGRLVPQPFPYGITADG-GLLSSVLDLAKYL 248
+PL ++ ++ + E + A GY K R V + P + A G+ ++V D+A ++
Sbjct: 200 KPLKLDHTWINVPKAE-EAHYAWGYRDGKAVRAV-RVSPGMLDAQAYGVKTNVQDMANWV 257
Query: 249 --KMYIERDESIVSKEYIEKMETSYIKV-------PWEIFGG--------EGYGYGLIIY 291
M E K+ I ++ Y ++ WE+ EG + +
Sbjct: 258 MANMAPENVADASLKQGIALAQSRYWRIGSMYQGLGWEMLNWPVEANTVVEGSDSKVALA 317
Query: 292 PNFLGE----------KLVGHSGSVGMYTGYIGYIPEKKIGVAVLENSSGYP 333
P + E V +GS G + Y+ +IPEK+IG+ +L N+S YP
Sbjct: 318 PLPVAEVNPPAPPVKASWVHKTGSTGGFGSYVAFIPEKQIGIVMLANTS-YP 368
>pdb|1GCE|A Chain A, Structure Of The Beta-Lactamase Of Enterobacter Cloacae
Gc1
Length = 364
Score = 96.0 bits (235), Expect = 8e-19
Identities = 91/352 (25%), Positives = 158/352 (44%), Gaps = 55/352 (15%)
Query: 14 MAERKVPGISISIIKDGDVVYAKGFGYRNVEARLPSTPETIYGIGSITKSFTALAIMKLV 73
M + VPG+++++I G Y FG ++ A P TP+T++ +GSI+K+FT + +
Sbjct: 20 MKAQSVPGMAVAVIYQGKPHYYT-FGKADIAANKPVTPQTLFELGSISKTFTGVLGGDAI 78
Query: 74 EEGGLSLDDPVEKFVNIKLRPFGEPVTVHHLLTHSSGIPSLGYAEAFIDGMVGGDNWLPV 133
G +SLDDPV ++ + + + L T+++G LP+
Sbjct: 79 ARGEISLDDPVTRYWPQLTGKQWQGIRMLDLATYTAG-------------------GLPL 119
Query: 134 STPEE---TIAFARDMEKWAVA-KPGERFFYLNTGYVLLGKIIEKVSGVSYEEYIKKKIL 189
P+E + R + W KPG Y N L G + K SG+ YE+ + ++L
Sbjct: 120 QVPDEVTDNASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMPYEQAMTTRVL 179
Query: 190 EPLGMNRSYFFKEEVEKDKDVAMGYILDKEGRLVPQPFPYGITADG-GLLSSVLDLAKYL 248
+PL ++ ++ + E + A GY K R V + P + A G+ ++V D+A ++
Sbjct: 180 KPLKLDHTWINVPKAE-EAHYAWGYRDGKAVRAV-RVSPGMLDAQAYGVKTNVQDMANWV 237
Query: 249 --KMYIERDESIVSKEYIEKMETSYIKV-------PWEIFGG--------EGYGYGLIIY 291
M E K+ I ++ Y ++ WE+ EG + +
Sbjct: 238 MANMAPENVADASLKQGIALAQSRYWRIGSMYQGLGWEMLNWPVEANTVVEGSDSKVALA 297
Query: 292 PNFLGE----------KLVGHSGSVGMYTGYIGYIPEKKIGVAVLENSSGYP 333
P + E V +GS G + Y+ +IPEK+IG+ +L N+S YP
Sbjct: 298 PLPVAEVNPPAPPVKASWVHKTGSTGGFGSYVAFIPEKQIGIVMLANTS-YP 348
>pir||A83422 hypothetical protein PA1797 [imported] - Pseudomonas aeruginosa
(strain PAO1) >gi|9947779|gb|AAG05186.1|AE004605_8
(AE004605) hypothetical protein [Pseudomonas aeruginosa]
Length = 610
Score = 95.6 bits (234), Expect = 1e-18
Identities = 75/288 (26%), Positives = 134/288 (46%), Gaps = 57/288 (19%)
Query: 6 LESFIVEKMAERKVPGISISIIKDGDVVYAKGFGYRNVEARLPSTPETIYGIGSITKSFT 65
L+ I +M + VPG++++++ D +V+A+GFGY + + R+ ++ T + G ++K
Sbjct: 43 LQRHIRREMERQDVPGLALALVDDQQLVWARGFGYADRQHRINASEHTAFHAGDLSKLLI 102
Query: 66 ALAIMKLVEEGGLSLDDPV-----EKFVNIKLR----PFGEPVTVHHLLTHSSGIP---- 112
A A ++L E G LSLD P+ E +V + +T LL+H SG+P
Sbjct: 103 ASATLQLAERGQLSLDAPLQDTLREFYVRSRFHADQSEADRAITFRRLLSHQSGLPGEHL 162
Query: 113 ---------SLGYAEAFIDGMVGGDNWLPVSTPEETIAFARDMEKWAVAKPGERFFYLNT 163
SLG A + G+ W PG + + N
Sbjct: 163 PPLFGERPNSLGQLPAKVSGV------------------------WLSNPPGTQVAHSNL 198
Query: 164 GYVLLGKIIEKVSGVSYEEYIKKKILEPLGMNRSYFFKEEVEKDKDVAMGYILDKEGRLV 223
GY L+G IE+ +G +E+++++ +L+PL M RS F + + + + A GY GR
Sbjct: 199 GYELVGAAIERNTGKHFEQHMREHLLDPLQMTRSSFARNALPQAQR-AHGY--SGGGR-- 253
Query: 224 PQPFPYGITADGGLLSSVLDLAKYLKMYI----ERDESIVSKEYIEKM 267
P L SS +DL+++++M ++ ++ K +E+M
Sbjct: 254 --PGSASDLPVNDLWSSPVDLSRFVRMLFANGRHKERQLLRKHSVEEM 299
>emb|CAB50867.1| (Y17716) beta-lactamase CMY-5 [Klebsiella oxytoca]
Length = 381
Score = 95.6 bits (234), Expect = 1e-18
Identities = 87/358 (24%), Positives = 159/358 (44%), Gaps = 62/358 (17%)
Query: 10 IVEKMAERKVPGISISIIKDGDVVYAKGFGYRNVEARLPSTPETIYGIGSITKSFTALAI 69
I M E+ +PG+++++I G Y +G ++ P T +T++ +GS++K+F +
Sbjct: 36 ITPLMQEQAIPGMAVAVIYQGKPYYFT-WGKADIANNHPVTQQTLFELGSVSKTFNGVLG 94
Query: 70 MKLVEEGGLSLDDPVEKFVNIKLRPFGEPVTVHHLLTHSSGIPSLGYAEAFIDGMVGGDN 129
+ G + DPV K+ + + + HL T+++G
Sbjct: 95 GDAIARGEIKFSDPVTKYWPELTGKQWQGIRLLHLATYTAG------------------- 135
Query: 130 WLPVSTPEET---IAFARDMEKWAVA-KPGERFFYLNTGYVLLGKIIEKVSGVSYEEYIK 185
LP+ P++ A + W PG + Y N+ L G + K SG+SYEE +
Sbjct: 136 GLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMT 195
Query: 186 KKILEPLGMNRSYFFKEEVEKDKDVAMGYILDKEGRLVPQPFPYGITADG-GLLSSVLDL 244
+++L+PL + ++ + E+ KD A GY +EG+ V P + A+ G+ SSV+D+
Sbjct: 196 RRVLQPLKLAHTWITVPQNEQ-KDYAWGY---REGKPV-HVSPGQLDAEAYGVKSSVIDM 250
Query: 245 AKYLKMYIERDESIVSKEYIE-----------KMETSYIKVPWE----------IFGGEG 283
A++++ D S V ++ ++ ++ Y + WE I G
Sbjct: 251 ARWVQ--ANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSD 308
Query: 284 YGYGLIIYPNF--------LGEKLVGHSGSVGMYTGYIGYIPEKKIGVAVLENSSGYP 333
L P + V +GS G + Y+ ++PEK +G+ +L N S YP
Sbjct: 309 SKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKS-YP 365
>emb|CAA76382.1| (Y16785) beta-lactamase class C [Proteus mirabilis]
Length = 381
Score = 95.6 bits (234), Expect = 1e-18
Identities = 87/358 (24%), Positives = 160/358 (44%), Gaps = 62/358 (17%)
Query: 10 IVEKMAERKVPGISISIIKDGDVVYAKGFGYRNVEARLPSTPETIYGIGSITKSFTALAI 69
I M E+ +PG+++++I G Y +G ++ P T +T++ +GS++K+F +
Sbjct: 36 ITPLMQEQAIPGMAVAVIYQGKPYYFT-WGKADIANNHPVTQQTLFELGSVSKTFNGVLG 94
Query: 70 MKLVEEGGLSLDDPVEKFVNIKLRPFGEPVTVHHLLTHSSGIPSLGYAEAFIDGMVGGDN 129
+ G + L DPV K+ + + + HL T+++G
Sbjct: 95 GDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAG------------------- 135
Query: 130 WLPVSTPEET---IAFARDMEKWAVA-KPGERFFYLNTGYVLLGKIIEKVSGVSYEEYIK 185
LP+ P++ A + W PG + Y N+ L G + K SG+SYEE +
Sbjct: 136 GLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYSNSSIGLFGALAVKPSGMSYEEAMT 195
Query: 186 KKILEPLGMNRSYFFKEEVEKDKDVAMGYILDKEGRLVPQPFPYGITADG-GLLSSVLDL 244
+++L+PL + ++ + E+ KD A GY +EG+ V P + A+ G+ SSV+D+
Sbjct: 196 RRVLQPLKLAHTWITVPQNEQ-KDYARGY---REGKPV-HVSPGQLDAEAYGVKSSVIDM 250
Query: 245 AKYLKMYIERDESIVSKEYIE-----------KMETSYIKVPWE----------IFGGEG 283
A++++ D S V ++ ++ ++ Y + WE I G
Sbjct: 251 ARWVQ--ANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSD 308
Query: 284 YGYGLIIYPNF--------LGEKLVGHSGSVGMYTGYIGYIPEKKIGVAVLENSSGYP 333
L P + V +GS G + Y+ ++PEK +G+ +L N + YP
Sbjct: 309 SKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLANKN-YP 365
>pir||PNKBQ beta-lactamase (EC 3.5.2.6) precursor - Enterobacter cloacae
(strain Q908R) (fragment) >gi|757841|emb|CAA30878.1|
(X08081) beta-lactamase precursor (1 is 2nd base in
codon) [Enterobacter cloacae]
Length = 375
Score = 95.2 bits (233), Expect = 1e-18
Identities = 90/352 (25%), Positives = 160/352 (44%), Gaps = 58/352 (16%)
Query: 14 MAERKVPGISISIIKDGDVVYAKGFGYRNVEARLPSTPETIYGIGSITKSFTALAIMKLV 73
M + VPG+++++I G Y FG ++ A P TP+T++ +GSI+K+FT + +
Sbjct: 34 MKAQSVPGMAVAVIYQGKPHYYT-FGKADIAANKPVTPQTLFELGSISKTFTGVLGGDAI 92
Query: 74 EEGGLSLDDPVEKFVNIKLRPFGEPVTVHHLLTHSSGIPSLGYAEAFIDGMVGGDNWLPV 133
G +SLDDPV ++ + + + L T+++G LP+
Sbjct: 93 ARGEISLDDPVTRYWPQLTGKQWQGIRMLDLATYTAG-------------------GLPL 133
Query: 134 STPEE---TIAFARDMEKWAVA-KPGERFFYLNTGYVLLGKIIEKVSGVSYEEYIKKKIL 189
P+E + R + W KPG Y N L G + K SG+ YE+ + ++L
Sbjct: 134 QVPDEVTDNASLVRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMPYEQAMTTRVL 193
Query: 190 EPLGMNRSYFFKEEVEKDKDVAMGYILDKEGRLVPQPFPYGITADG-GLLSSVLDLAKYL 248
+PL ++ ++ + E + A GY ++G+ V + P + A G+ ++V D+A ++
Sbjct: 194 KPLKLDHTWINVPKAE-EAHYAWGY---RDGKAV-RVSPGMLDAQAYGVKTNVQDMANWV 248
Query: 249 --KMYIERDESIVSKEYIEKMETSYIKV-------PWEIFGG--------EGYGYGLIIY 291
M E K+ I ++ Y ++ WE+ EG + +
Sbjct: 249 MANMAPENVADASLKQGIALAQSRYWRIGSMYQGLGWEMLNWPVEANTVVEGSDSKVALA 308
Query: 292 PNFLGE----------KLVGHSGSVGMYTGYIGYIPEKKIGVAVLENSSGYP 333
P + E V +GS G + Y+ +IPEK+IG+ +L N+S YP
Sbjct: 309 PLPVVEVNPPAPPVKASWVHKTGSTGGFGSYVAFIPEKQIGIVMLANTS-YP 359
>pir||S39196 beta-lactamase (EC 3.5.2.6) - Escherichia coli
>gi|433561|emb|CAA52618.1| (X74512) beta-lactamase
[Escherichia coli]
Length = 381
Score = 95.2 bits (233), Expect = 1e-18
Identities = 86/358 (24%), Positives = 159/358 (44%), Gaps = 62/358 (17%)
Query: 10 IVEKMAERKVPGISISIIKDGDVVYAKGFGYRNVEARLPSTPETIYGIGSITKSFTALAI 69
I M E+ +PG+++++I G Y +G ++ P T +T++ +GS++K+F +
Sbjct: 36 ITPLMQEQAIPGMAVAVIYQGKPYYFT-WGKADIANNHPVTQQTLFELGSVSKTFNGVLG 94
Query: 70 MKLVEEGGLSLDDPVEKFVNIKLRPFGEPVTVHHLLTHSSGIPSLGYAEAFIDGMVGGDN 129
+ G + L DPV K+ + + + HL T+++G
Sbjct: 95 RDAIARGEIKLSDPVTKYWPELTGKQWQGIRLLHLATYTAG------------------- 135
Query: 130 WLPVSTPEET---IAFARDMEKWAVA-KPGERFFYLNTGYVLLGKIIEKVSGVSYEEYIK 185
LP+ P++ A + W PG + Y N+ L G + K SG+SYEE +
Sbjct: 136 GLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGALAVKPSGMSYEEAMT 195
Query: 186 KKILEPLGMNRSYFFKEEVEKDKDVAMGYILDKEGRLVPQPFPYGITADG-GLLSSVLDL 244
+++L+PL + ++ + E+ KD A Y +EG+ V P + A+ G+ SSV+D+
Sbjct: 196 RRVLQPLKLAHTWITVPQNEQ-KDYAWAY---REGKPV-HVSPGQLDAEAYGVKSSVIDM 250
Query: 245 AKYLKMYIERDESIVSKEYIE-----------KMETSYIKVPWE----------IFGGEG 283
A++++ D S V ++ ++ ++ Y + WE I G
Sbjct: 251 ARWVQ--ANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKADSIINGSD 308
Query: 284 YGYGLIIYPNF--------LGEKLVGHSGSVGMYTGYIGYIPEKKIGVAVLENSSGYP 333
L P + V +GS G + Y+ ++PEK +G+ ++ N S YP
Sbjct: 309 TKVALAAVPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVIVANKS-YP 365
>emb|CAA06639.1| (AJ005633) AmpC-type beta-lactamase [Enterobacter cloacae]
Length = 381
Score = 94.8 bits (232), Expect = 2e-18
Identities = 90/352 (25%), Positives = 159/352 (44%), Gaps = 58/352 (16%)
Query: 14 MAERKVPGISISIIKDGDVVYAKGFGYRNVEARLPSTPETIYGIGSITKSFTALAIMKLV 73
M + VPG+++++I G Y FG ++ A P TP+T++ +GSI+K+FT + +
Sbjct: 40 MKAQSVPGMAVAVIYQGKSHYYT-FGKADIAANKPVTPQTLFELGSISKTFTGVLGGDAI 98
Query: 74 EEGGLSLDDPVEKFVNIKLRPFGEPVTVHHLLTHSSGIPSLGYAEAFIDGMVGGDNWLPV 133
G +SLDDPV ++ + + + L T+++G LP+
Sbjct: 99 ARGEISLDDPVTRYWPQLTGKQWQGIRMLDLATYTAG-------------------GLPL 139
Query: 134 STPEE---TIAFARDMEKWAVA-KPGERFFYLNTGYVLLGKIIEKVSGVSYEEYIKKKIL 189
P+E + R + W KPG Y N L G + K SG+ YE+ + ++L
Sbjct: 140 QVPDEVTDNASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMPYEQAMTTRVL 199
Query: 190 EPLGMNRSYFFKEEVEKDKDVAMGYILDKEGRLVPQPFPYGITADG-GLLSSVLDLAKYL 248
+PL ++ ++ + E + A GY ++G+ V + P + A G+ ++V D+A ++
Sbjct: 200 KPLKLDHTWINVPKAE-EAHYAWGY---RDGKAV-RVSPGMLDAQAYGVKTNVQDMANWV 254
Query: 249 --KMYIERDESIVSKEYIEKMETSYIKV-------PWEIFGG--------EGYGYGLIIY 291
M E+ K+ I ++ Y ++ WE+ EG + +
Sbjct: 255 MANMAPEKVADASLKQGIALAQSRYWRIGSMYQGLGWEMLNWPVEANTVVEGSDSKVALA 314
Query: 292 PNFLGE----------KLVGHSGSVGMYTGYIGYIPEKKIGVAVLENSSGYP 333
P E V +GS G + Y+ +IPEK+IG+ +L N S YP
Sbjct: 315 PLPEAEVNPPAPPVKASWVHKTGSTGGFGSYVAFIPEKQIGIVMLANKS-YP 365
>sp|Q06317|PBP4_NOCLA PENICILLIN-BINDING PROTEIN 4 (PBP-4) >gi|480041|pir||S36189
penicllin-binding protein 4 - Streptomyces lactamdurans
>gi|44999|emb|CAA78374.1| (Z13972) cmcPBP [Streptomyces
lactamdurans]
Length = 381
Score = 94.0 bits (230), Expect = 3e-18
Identities = 84/331 (25%), Positives = 151/331 (45%), Gaps = 38/331 (11%)
Query: 16 ERKVPGISISIIKDGDV-VYAKGFGYRNVEARLPSTPETIYGIGSITKSFTALAIMKLVE 74
E VPG ++++ DGD+ A G +R + T ++++ GS+ K +TA +M+LV+
Sbjct: 18 EHHVPGAALAVFVDGDLHELASGVLHRGTGVAV--TTDSVFQSGSVAKVYTATLVMQLVD 75
Query: 75 EGGLSLDDPVEKFVN---IKLRPFGEPVTVHHLLTHSSGIPSLGYAEAFIDGMVGGDNWL 131
G L LD V + + VT+ LL+H+SGI GD L
Sbjct: 76 AGELRLDTRVADVLPGFAVADAEVARTVTIGRLLSHTSGI--------------AGDFTL 121
Query: 132 PVSTPEETIAFARDM--EKWAVAKPGERFFYLNTGYVLLGKIIEKVSGVSYEEYIKKKIL 189
++ +A D + P Y +TGY +LG+I+E ++G S+++ ++ ++
Sbjct: 122 DTGRGDDCLARFVDACADVGQDCPPDTVISYCSTGYAILGRIVEVLTGQSWDDALRDRLF 181
Query: 190 EPLGMNRSYFFKEEVEKDKDVAMGYI----LDKEGRLVPQPFPYGITADGGLLSSVLDLA 245
PLG+++S EE + + VAM ++ D E V P G +L + D+
Sbjct: 182 TPLGLHQSMTLPEEALRFR-VAMSHLGELGTDPEPAPVWDMLPRSAGPYGRVLITAADVV 240
Query: 246 KYLKMYIE--------RDESIVSKEYIEKMETSYIKVPWEIFGGEGYGYGLIIYPNFLGE 297
++ +M+++ R S S + + + W F G+G+G +Y ++ G
Sbjct: 241 RFARMHLDDGVAPDGTRVLSAASAALMRQQVAGCLDT-WS-FMATGWGHGWALY-DWDGV 297
Query: 298 KLVGHSGSVGMYTGYIGYIPEKKIGVAVLEN 328
GH G+ G Y+ +P + A+L N
Sbjct: 298 PGYGHDGASGGQFSYLRVVPGSGVVAALLTN 328
>emb|CAC16709.1| (AL450289) putative hydrolase [Streptomyces coelicolor]
Length = 393
Score = 94.0 bits (230), Expect = 3e-18
Identities = 88/308 (28%), Positives = 146/308 (46%), Gaps = 45/308 (14%)
Query: 11 VEKMAERKVPGISISIIKDGDVVYAKGFGYRNVEARLPSTPETIYGIGSITKSFTALAIM 70
VE + +PG+ + ++DGD V+ G +V+ P T + + +GSITK+FTA A++
Sbjct: 35 VENVHRAGMPGL-FAEVRDGDQVWRGAAGVADVDTGRPVTADLRHRVGSITKTFTAAAVL 93
Query: 71 KLVEEGGLSLDDPVEKFV-NIKLRPFGEPVTVHHLLTHSSGIPS-LGYAEAFIDGMVGGD 128
+ VE+G + LD P+ +++ + GE VTV L+ H+SG+ L +A + +
Sbjct: 94 QQVEQGRIVLDAPIGRYLPGLLPDGRGEAVTVRMLMNHTSGLAEYLPHAYSSLKAFPALA 153
Query: 129 NWLPVS---------TPEETIAFARDMEKWAVAKP-GERFFYLNTGYVLLGKIIEKVSGV 178
+ P S P E IA + AV P G Y NT Y+LLGK++E+V+G
Sbjct: 154 DTGPQSLDDHRFTRFDPAELIALG--VAAPAVGPPGGAPGLYSNTNYLLLGKLLEEVTGT 211
Query: 179 SYEEYIKKKILEPLGMNRSYFFKEEVEKDKDVAMG-YILDKEGRL-------VPQPFPYG 230
S E I + ++E G+ +D ++ G Y+ + RL + P Y
Sbjct: 212 SAERCITRNVIERAGL-----------RDTELPTGPYVGEPHSRLYESWFGMIDPPRDYS 260
Query: 231 ------ITADGGLLSSVLDLAKYLKMYIERDESIVSKEYIEKMETSYIKVPWEIFGGEGY 284
+ L+S+V DL ++ M + + IVS + +M + V E G
Sbjct: 261 VYDMSWVGPSASLISTVSDLNRFFGMLLAGE--IVSPSSLAQMRRTVPVVSQE---GRTI 315
Query: 285 GYGLIIYP 292
YGL ++P
Sbjct: 316 EYGLGLHP 323
>gb|AAF18992.1|AF211348_1 (AF211348) beta-lactamase AmpC [Enterobacter aerogenes]
Length = 381
Score = 93.6 bits (229), Expect = 4e-18
Identities = 86/359 (23%), Positives = 166/359 (45%), Gaps = 64/359 (17%)
Query: 10 IVEKMAERKVPGISISIIKDGDVVYAKGFGYRNVEARLPSTPETIYGIGSITKSFTALAI 69
I M E+ +PG+++++I G Y +G +V + P T +T++ +GS++K+FT +
Sbjct: 36 ITPLMKEQAIPGMAVAVIYHGKPYYFT-WGQADVAGQRPVTRQTLFELGSVSKTFTGVLG 94
Query: 70 MKLVEEGGLSLDDPVEKFVNIKLRPFGEPVTVHHLLTHSSGIPSLGYAEAFIDGMVGGDN 129
V G + L DP +K+ + +++ HL T+++G
Sbjct: 95 GDAVARGEIKLSDPAQKYWPQLTGQQWQGISLLHLATYTAG------------------- 135
Query: 130 WLPVSTPEET---IAFARDMEKWAVA-KPGERFFYLNTGYVLLGKIIEKVSGVSYEEYIK 185
LP+ P+E A R + W PG + Y N L G + K SG+S+E+ +
Sbjct: 136 GLPLQVPDEVTDEAALLRYYQNWQPQWAPGSKRLYANASIGLFGALAVKPSGMSFEQAMS 195
Query: 186 KKILEPLGMNRSYFFKEEVEKDKDVAMGYILDKEGRLVPQPFPYGITADG-GLLSSVLDL 244
+++L+PL ++ ++ + KD A GY ++G+ V P + A+ G+ SS+ D+
Sbjct: 196 QRVLQPLKLSHTW-INVPPAQSKDYAWGY---RDGKAV-HVSPGQLDAEAYGVKSSIEDM 250
Query: 245 AKYL--KMYIERDESIVSKEYIEKMETSYIKVPWEIFGGEGYGYGLIIYP-------NFL 295
A ++ M E + ++ I+ ++ Y + E++ +G G+ ++ +P N
Sbjct: 251 AHWVLANMNSEAVQDKNLRQGIQLAQSRYWRA-GEMY--QGLGWEMLNWPVPAEVVINGS 307
Query: 296 GEKL---------------------VGHSGSVGMYTGYIGYIPEKKIGVAVLENSSGYP 333
K+ V +GS G + Y+ +IP++ +G+ +L N S YP
Sbjct: 308 DNKVALAATPVTAVNPPAPSVKASWVHKTGSTGGFGSYVAFIPQQDLGIVMLANKS-YP 365
>gb|AAD12161.1| (AF055922) dipeptidil carboxypeptidase [Streptomyces fradiae]
Length = 398
Score = 93.6 bits (229), Expect = 4e-18
Identities = 93/326 (28%), Positives = 147/326 (44%), Gaps = 30/326 (9%)
Query: 30 GDVVYAKGFGYRNVEARLPSTPETIYGIGSITKSFTALAIMKLVEEGGLSLDDPVEKFVN 89
G V GFG + +A P + + IGS+TK+F A +++LV EG LSLDD V+ ++
Sbjct: 68 GTVKVRSGFG--DTDAGTPVPWKARFRIGSLTKTFVAATVLQLVGEGKLSLDDTVDHWLP 125
Query: 90 IKLRPFGEP---VTVHHLLTHSSG----IPSLGYAEAFIDGMVGGDNWLPVSTPEETIAF 142
+ G +TV LL H+SG +P L Y F++ G + + V PE+ +
Sbjct: 126 GLVSGRGNDGSAITVGMLLRHTSGLRDYVPELPYI--FLEKEYGPNRFRTVR-PEQAVRL 182
Query: 143 ARDMEKWAVAKPGERFFYLNTGYVLLGKIIEKVSGVSYEEYIKKKILEPLGMNRSYFFKE 202
A + V PG R+ Y NT Y+L G I+EK +G S++ ++ +++EPLG+ +Y
Sbjct: 183 A--LRHPPVFAPGTRWGYSNTNYILAGMIVEKATGHSWQHEVRTRVIEPLGLRHTYAPDT 240
Query: 203 EVEKDKDVAMGYILDKEGRLVPQPF------PYGIT--------ADGGLLSSVLDLAKYL 248
A+GY E L P P +T A G ++S+ D ++L
Sbjct: 241 FPFIPGPHAVGYQRFAEKGLEADPADPRWGEPVDVTVGNPSWGGAAGEMISTTEDGNRFL 300
Query: 249 KMYIERDESIVSKEYIEKMETSYIKVPWEIFGGEGYGYGLIIYPNFLGEKLVGHSGSVGM 308
+ + E + E E +T + G YG GL+ PN G + H G +
Sbjct: 301 RALL-GGEVLRPAELAEMKKTVRAGEFDSAWPGVRYGLGLMWAPNSCG-GVWFHGGDIPG 358
Query: 309 YTGYIGYIPEKKIGVAVLENSSGYPP 334
+ G + V V N+ P
Sbjct: 359 FKTRNGVTGDGSRSVMVSVNTQSMVP 384
>emb|CAB37344.2| (AJ009971) hypothetical protein [Streptomyces fradiae]
Length = 408
Score = 93.6 bits (229), Expect = 4e-18
Identities = 93/326 (28%), Positives = 147/326 (44%), Gaps = 30/326 (9%)
Query: 30 GDVVYAKGFGYRNVEARLPSTPETIYGIGSITKSFTALAIMKLVEEGGLSLDDPVEKFVN 89
G V GFG + +A P + + IGS+TK+F A +++LV EG LSLDD V+ ++
Sbjct: 68 GTVKVRSGFG--DTDAGTPVPWKARFRIGSLTKTFVAATVLQLVGEGKLSLDDTVDHWLP 125
Query: 90 IKLRPFGEP---VTVHHLLTHSSG----IPSLGYAEAFIDGMVGGDNWLPVSTPEETIAF 142
+ G +TV LL H+SG +P L Y F++ G + + V PE+ +
Sbjct: 126 GLVSGRGNDGSAITVGMLLRHTSGLRDYVPELPYI--FLEKEYGPNRFRTVR-PEQAVRL 182
Query: 143 ARDMEKWAVAKPGERFFYLNTGYVLLGKIIEKVSGVSYEEYIKKKILEPLGMNRSYFFKE 202
A + V PG R+ Y NT Y+L G I+EK +G S++ ++ +++EPLG+ +Y
Sbjct: 183 A--LRHPPVFAPGTRWGYSNTNYILAGMIVEKATGHSWQHEVRTRVIEPLGLRHTYAPDT 240
Query: 203 EVEKDKDVAMGYILDKEGRLVPQPF------PYGIT--------ADGGLLSSVLDLAKYL 248
A+GY E L P P +T A G ++S+ D ++L
Sbjct: 241 FPFIPGPHAVGYQRFAEKGLEADPADPRWGEPVDVTVGNPSWGGAAGEMISTTEDGNRFL 300
Query: 249 KMYIERDESIVSKEYIEKMETSYIKVPWEIFGGEGYGYGLIIYPNFLGEKLVGHSGSVGM 308
+ + E + E E +T + G YG GL+ PN G + H G +
Sbjct: 301 RALL-GGEVLRPAELAEMKKTVRAGEFDSAWPGVRYGLGLMWAPNSCG-GVWFHGGDIPG 358
Query: 309 YTGYIGYIPEKKIGVAVLENSSGYPP 334
+ G + V V N+ P
Sbjct: 359 FKTRNGVTGDGSRSVMVSVNTQSMVP 384
>pdb|2BLT|A Chain A, Beta-Lactamase (E.C.3.5.2.6) (Cephalosporinase)
>gi|999837|pdb|2BLT|B Chain B, Beta-Lactamase
(E.C.3.5.2.6) (Cephalosporinase) >gi|1065133|pdb|1BLS|A
Chain A, Beta-Lactamase (E.C.3.5.2.6) (Cephalosporinase)
Complexed With A Phosphonate Inhibitor
>gi|1065134|pdb|1BLS|B Chain B, Beta-Lactamase
(E.C.3.5.2.6) (Cephalosporinase) Complexed With A
Phosphonate Inhibitor
Length = 361
Score = 93.2 bits (228), Expect = 5e-18
Identities = 90/356 (25%), Positives = 160/356 (44%), Gaps = 58/356 (16%)
Query: 10 IVEKMAERKVPGISISIIKDGDVVYAKGFGYRNVEARLPSTPETIYGIGSITKSFTALAI 69
I M + VPG+++++I G Y FG ++ A P TP+T++ +GSI+K+FT +
Sbjct: 16 ITPLMKAQSVPGMAVAVIYQGKPHYYT-FGKADIAANKPVTPQTLFELGSISKTFTGVLG 74
Query: 70 MKLVEEGGLSLDDPVEKFVNIKLRPFGEPVTVHHLLTHSSGIPSLGYAEAFIDGMVGGDN 129
+ G +SLDD V ++ + + + L T+++G
Sbjct: 75 GDAIARGEISLDDAVTRYWPQLTGKQWQGIRMLDLATYTAG------------------- 115
Query: 130 WLPVSTPEE---TIAFARDMEKWAVA-KPGERFFYLNTGYVLLGKIIEKVSGVSYEEYIK 185
LP+ P+E + R + W KPG Y N L G + K SG+ YE+ +
Sbjct: 116 GLPLQVPDEVTDNASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMPYEQAMT 175
Query: 186 KKILEPLGMNRSYFFKEEVEKDKDVAMGYILDKEGRLVPQPFPYGITADG-GLLSSVLDL 244
++L+PL ++ ++ + E + A GY ++G+ V + P + A G+ ++V D+
Sbjct: 176 TRVLKPLKLDHTWINVPKAE-EAHYAWGY---RDGKAV-RVSPGMLDAQAYGVKTNVQDM 230
Query: 245 AKYL--KMYIERDESIVSKEYIEKMETSYIKV-------PWEIFGG--------EGYGYG 287
A ++ M E K+ I ++ Y ++ WE+ EG
Sbjct: 231 ANWVMANMAPENVADASLKQGIALAQSRYWRIGSMYQGLGWEMLNWPVEANTVVEGSDSK 290
Query: 288 LIIYPNFLGE----------KLVGHSGSVGMYTGYIGYIPEKKIGVAVLENSSGYP 333
+ + P + E V +GS G + Y+ +IPEK+IG+ +L N+S YP
Sbjct: 291 VALAPLPVAEVNPPAPPVKASWVHKTGSTGGFGSYVAFIPEKQIGIVMLANTS-YP 345
>sp|P05364|AMPC_ENTCL BETA-LACTAMASE PRECURSOR (CEPHALOSPORINASE) >gi|67778|pir||PNKBP
beta-lactamase (EC 3.5.2.6) precursor - Enterobacter
cloacae (strain P99) >gi|42261|emb|CAA30257.1| (X07274)
beta-lactamase precursor [Enterobacter cloacae]
Length = 381
Score = 93.2 bits (228), Expect = 5e-18
Identities = 90/356 (25%), Positives = 160/356 (44%), Gaps = 58/356 (16%)
Query: 10 IVEKMAERKVPGISISIIKDGDVVYAKGFGYRNVEARLPSTPETIYGIGSITKSFTALAI 69
I M + VPG+++++I G Y FG ++ A P TP+T++ +GSI+K+FT +
Sbjct: 36 ITPLMKAQSVPGMAVAVIYQGKPHYYT-FGKADIAANKPVTPQTLFELGSISKTFTGVLG 94
Query: 70 MKLVEEGGLSLDDPVEKFVNIKLRPFGEPVTVHHLLTHSSGIPSLGYAEAFIDGMVGGDN 129
+ G +SLDD V ++ + + + L T+++G
Sbjct: 95 GDAIARGEISLDDAVTRYWPQLTGKQWQGIRMLDLATYTAG------------------- 135
Query: 130 WLPVSTPEE---TIAFARDMEKWAVA-KPGERFFYLNTGYVLLGKIIEKVSGVSYEEYIK 185
LP+ P+E + R + W KPG Y N L G + K SG+ YE+ +
Sbjct: 136 GLPLQVPDEVTDNASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMPYEQAMT 195
Query: 186 KKILEPLGMNRSYFFKEEVEKDKDVAMGYILDKEGRLVPQPFPYGITADG-GLLSSVLDL 244
++L+PL ++ ++ + E + A GY ++G+ V + P + A G+ ++V D+
Sbjct: 196 TRVLKPLKLDHTWINVPKAE-EAHYAWGY---RDGKAV-RVSPGMLDAQAYGVKTNVQDM 250
Query: 245 AKYL--KMYIERDESIVSKEYIEKMETSYIKV-------PWEIFGG--------EGYGYG 287
A ++ M E K+ I ++ Y ++ WE+ EG
Sbjct: 251 ANWVMANMAPENVADASLKQGIALAQSRYWRIGSMYQGLGWEMLNWPVEANTVVEGSDSK 310
Query: 288 LIIYPNFLGE----------KLVGHSGSVGMYTGYIGYIPEKKIGVAVLENSSGYP 333
+ + P + E V +GS G + Y+ +IPEK+IG+ +L N+S YP
Sbjct: 311 VALAPLPVAEVNPPAPPVKASWVHKTGSTGGFGSYVAFIPEKQIGIVMLANTS-YP 365
>sp|P94958|AMPC_MORMO BETA-LACTAMASE PRECURSOR (CEPHALOSPORINASE)
>gi|1781033|emb|CAA71326.1| (Y10283) beta-lactamase
class C [Morganella morganii]
Length = 379
Score = 92.1 bits (225), Expect = 1e-17
Identities = 84/370 (22%), Positives = 166/370 (44%), Gaps = 55/370 (14%)
Query: 6 LESFIVEKMAERKVPGISISIIKDGDVVYAKGFGYRNVEARLPSTPETIYGIGSITKSFT 65
++S I MA++ +PG+++++ G Y +G+ +V+A+ P T T++ +GS++K+FT
Sbjct: 31 VDSTIKPLMAQQDIPGMAVAVSVKGKPYYFN-YGFADVQAKQPVTENTLFELGSVSKTFT 89
Query: 66 ALAIMKLVEEGGLSLDDPVEKFVNIKLRPFGEPVTVHHLLTHSSGIPSLGYAEAFIDGMV 125
+ V + ++L+DP EK+ P + +T+ L T+++G
Sbjct: 90 GVLGAVSVAKKEMTLNDPAEKYQPELALPQWKGITLLDLATYTAG--------------- 134
Query: 126 GGDNWLPVSTPEETIAFA---RDMEKWAVA-KPGERFFYLNTGYVLLGKIIEKVSGVSYE 181
LP+ P+ + A ++W + KPG+ Y N+ L G + +G+ YE
Sbjct: 135 ----GLPLQVPDAVKSRADLLHFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYE 190
Query: 182 EYIKKKILEPLGMNRSYFFKEEVEKDKDVAMGYILDKEGRLVPQPFPYGITADGGLLSSV 241
+ + +IL PLG++ ++ E A GY K R+ P G+ S+
Sbjct: 191 QLLTARILAPLGLSHTFITVPE-SAQSQYAYGYKNKKPVRVSPGQLD---AESYGVKSAS 246
Query: 242 LDLAKYLKMYIE--RDESIVSKEYIEKMETSYIK-------VPWEIFGG--------EGY 284
D+ ++ +M +E R + + + +T Y K + WE++ G
Sbjct: 247 KDMLRWAEMNMEPSRAGNADLEMAMYLAQTRYYKTAAINQGLGWEMYDWPQQKDMIINGV 306
Query: 285 GYGLIIYPN---------FLGEKLVGHSGSVGMYTGYIGYIPEKKIGVAVLENSSGYPPS 335
+ + P+ + V +G+ + Y+ +IPEK++ + +L N + YP +
Sbjct: 307 TNEVALQPHPVTDNQVQPYNRASWVHKTGATTGFGAYVAFIPEKQVAIVILANKN-YPNT 365
Query: 336 YIAMYALALL 345
A A+L
Sbjct: 366 ERVKAAQAIL 375
>gb|AAG36927.1|AF259520_4 (AF259520) cephalosporinase DHA-2 [Klebsiella pneumoniae]
Length = 379
Score = 91.7 bits (224), Expect = 2e-17
Identities = 85/367 (23%), Positives = 165/367 (44%), Gaps = 49/367 (13%)
Query: 6 LESFIVEKMAERKVPGISISIIKDGDVVYAKGFGYRNVEARLPSTPETIYGIGSITKSFT 65
++S I MA++ +PG+++++ G Y +G+ +V+A+ P T T++ +GS++K+FT
Sbjct: 31 VDSTIKPLMAQQDIPGMAVAVSVKGKPYYFN-YGFADVQAKQPVTENTLFELGSVSKTFT 89
Query: 66 ALAIMKLVEEGGLSLDDPVEKFVNIKLRPFGEPVTVHHLLTHSSGIPSLGYAEAFIDGMV 125
+ V + + L+DP EK+ P + +T+ L T+++G L +A
Sbjct: 90 GVLGAVSVAKKEMMLNDPAEKYQPELALPQWKGITLLDLATYTTGGLPLQVPDA------ 143
Query: 126 GGDNWLPVSTPEETIAFARDMEKWAVA-KPGERFFYLNTGYVLLGKIIEKVSGVSYEEYI 184
V E + F ++W + KPG+ Y N+ L G + +G+ YE+ +
Sbjct: 144 -------VKNRAELLHF---YQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYEQLL 193
Query: 185 KKKILEPLGMNRSYFFKEEVEKDKDVAMGYILDKEGRLVPQPFPYGITADGGLLSSVLDL 244
+IL PLG++ ++ E A GY K R+ P G+ S+ D+
Sbjct: 194 TARILAPLGLSHTFITVPE-SAQSQYAYGYKNKKPVRVSPGQLD---AESYGVKSASKDM 249
Query: 245 AKYLKMYIE--RDESIVSKEYIEKMETSYIK-------VPWEIFGG--------EGYGYG 287
++ +M +E R + + + +T Y K + WE++ G
Sbjct: 250 LRWAEMNMEPSRAGNADLEMAMYLAQTRYYKTAAINQGLGWEMYDWPQQKDMIINGVTNE 309
Query: 288 LIIYPN---------FLGEKLVGHSGSVGMYTGYIGYIPEKKIGVAVLENSSGYPPSYIA 338
+ + P+ + V +G+ + Y+ +IPEK++ + +L N + YP +
Sbjct: 310 VALQPHPVTDNQVQPYNRASWVHKTGATTGFGAYVAFIPEKQVAIVILANKN-YPNTERV 368
Query: 339 MYALALL 345
A A+L
Sbjct: 369 KAAQAIL 375
>pir||T35438 probable secreted peptidase - Streptomyces coelicolor
>gi|3319726|emb|CAA19892.1| (AL031035) putative secreted
peptidase [Streptomyces coelicolor A3(2)]
Length = 386
Score = 90.9 bits (222), Expect = 3e-17
Identities = 58/165 (35%), Positives = 89/165 (53%), Gaps = 10/165 (6%)
Query: 39 GYRNVEARLPSTPETIYGIGSITKSFTALAIMKLVEEGGLSLDDPVEKFVNIKLRP-FGE 97
G R++ + P+ P+ + GSITK TA +++L + + LD PV+ ++ P F +
Sbjct: 79 GVRDLASGRPAHPDARFRAGSITKVVTAATVLRLAAQDEIDLDAPVQGYLPDLFTPDFEQ 138
Query: 98 PVTVHHLLTHSSGI-PSLGYAEAFIDGMVGGDNWLPVSTPEETIA--FARDMEKWAVAKP 154
PV+V HLL H+SGI P G + F + + TP++ A A+ E + P
Sbjct: 139 PVSVRHLLNHTSGIKPGDGLGDDFAELY---SHRYETLTPQQVAASAIAKGPEDFV---P 192
Query: 155 GERFFYLNTGYVLLGKIIEKVSGVSYEEYIKKKILEPLGMNRSYF 199
G R YLN Y +LG +IEKV+G SY + +L P GM+ +YF
Sbjct: 193 GTRQQYLNINYTILGLLIEKVTGRSYASEATRLVLRPAGMHHTYF 237
>emb|CAA76196.1| (Y16410) beta-lactamase class C [Salmonella enteritidis]
>gi|3790542|gb|AAC68582.1| (AF055067) cephalosporinase
[Morganella morganii] >gi|4585847|emb|CAB40919.1|
(AJ237702) DHA-1 [Salmonella enteritidis]
Length = 379
Score = 89.3 bits (218), Expect = 8e-17
Identities = 82/370 (22%), Positives = 165/370 (44%), Gaps = 55/370 (14%)
Query: 6 LESFIVEKMAERKVPGISISIIKDGDVVYAKGFGYRNVEARLPSTPETIYGIGSITKSFT 65
++S I MA++ +PG+++++ G Y +G+ +++A+ P T T++ +GS++K+FT
Sbjct: 31 VDSTIKPLMAQQDIPGMAVAVSVKGKPYYFN-YGFADIQAKQPVTENTLFELGSVSKTFT 89
Query: 66 ALAIMKLVEEGGLSLDDPVEKFVNIKLRPFGEPVTVHHLLTHSSGIPSLGYAEAFIDGMV 125
+ V + ++L+DP K+ P + +T+ L T+++G
Sbjct: 90 GVLGAVSVAKKEMALNDPAAKYQPELALPQWKGITLLDLATYTAG--------------- 134
Query: 126 GGDNWLPVSTPEETIAFA---RDMEKWAVA-KPGERFFYLNTGYVLLGKIIEKVSGVSYE 181
LP+ P+ + A ++W + KPG+ Y N+ L G + +G+ YE
Sbjct: 135 ----GLPLQVPDAVKSRADLLNFYQQWQPSRKPGDMRLYANSSIGLFGALTANAAGMPYE 190
Query: 182 EYIKKKILEPLGMNRSYFFKEEVEKDKDVAMGYILDKEGRLVPQPFPYGITADGGLLSSV 241
+ + +IL PLG++ ++ E A GY K R+ P G+ S+
Sbjct: 191 QLLTARILAPLGLSHTFITVPE-SAQSQYAYGYKNKKPVRVSPGQLD---AESYGVKSAS 246
Query: 242 LDLAKYLKMYIE--RDESIVSKEYIEKMETSYIK-------VPWEIFGG--------EGY 284
D+ ++ +M +E R + + + +T Y K + WE++ G
Sbjct: 247 KDMLRWAEMNMEPSRAGNADLEMAMYLAQTRYYKTAAINQGLGWEMYDWPQQKDMIINGV 306
Query: 285 GYGLIIYPN---------FLGEKLVGHSGSVGMYTGYIGYIPEKKIGVAVLENSSGYPPS 335
+ + P+ + V +G+ + Y+ +IPEK++ + +L N + YP +
Sbjct: 307 TNEVALQPHPVTDNQVQPYNRASWVHKTGATTGFGAYVAFIPEKQVAIVILANKN-YPNT 365
Query: 336 YIAMYALALL 345
A A+L
Sbjct: 366 ERVKAAQAIL 375
>gb|AAF26905.1|AF210843_2 (AF210843) unknown [Sorangium cellulosum]
Length = 423
Score = 88.9 bits (217), Expect = 1e-16
Identities = 92/368 (25%), Positives = 164/368 (44%), Gaps = 54/368 (14%)
Query: 13 KMAERKVPGISISIIKDGDVVYAKGFGYRNVEARLPSTPETIYGIGSITKSFTALAIMKL 72
++A ++PG ++ ++ GD V+ G + P +TI+ I S+TK+ TA A+M L
Sbjct: 42 EVAAGQMPG-AVWLVARGDDVHVDAVGVTELGGSAPMRRDTIFRIASMTKAVTATAVMML 100
Query: 73 VEEGGLSLDDPVEKFV----NIKLR-----------PFGEPVTVHHLLTHSSGIPSLGYA 117
VEEG L LD PV++++ N K+ P P+TV L+T + G A
Sbjct: 101 VEEGKLDLDSPVDRWLPELANRKVLARIDGPIDETVPAERPITVRDLMTFTMGFGISFDA 160
Query: 118 EAFIDGMV---GGDNWLPV-STPEETIAFARDMEKWAVA-KPGERFFYLNTGYVLLGKII 172
+ I + G N PV TP + R + + +PG ++ Y NTG ++ G ++
Sbjct: 161 SSPIQRAIDELGLVNAQPVPMTPHGPDEWIRRLGTLPLMHQPGAQWMY-NTGSLVQGVLV 219
Query: 173 EKVSGVSYEEYIKKKILEPLGMNRSYFFKEEVEKDKDVAMGYILDKE------------- 219
+ + ++ +++++IL PLGM + F + + GY D++
Sbjct: 220 GRAADQGFDAFVRERILAPLGMRDTDFHVPADKLARFAGCGYFTDEQTGEKTRMDRDGAE 279
Query: 220 -GRLVPQPFPYGITADGGLLSSVLDLAKYLKMY----IERDESIVSKEYIEKMETSYI-- 272
P FP G GL+S+V D + +M + ++S + +M ++
Sbjct: 280 SAYASPPAFPSGA---AGLVSTVDDYLLFARMLMNGGVHEGRRLLSAASVREMTADHLTP 336
Query: 273 --KVPWEIFGG----EGYGYGLIIY--PNFLGEKLVGHSGSVGMYTGYIGYIPEKKIGVA 324
K F G G+GYG+ + P+ + E + G T +I + IG+
Sbjct: 337 AQKAASSFFPGFFETHGWGYGMAVVTAPDAVSEVPGRYGWDGGFGTSWINDPGRELIGI- 395
Query: 325 VLENSSGY 332
V+ S+G+
Sbjct: 396 VMTQSAGF 403
>pir||T26938 hypothetical protein Y45F10D.11 - Caenorhabditis elegans
>gi|3880999|emb|CAA16386.1| (AL021492) Y45F10D.11
[Caenorhabditis elegans]
Length = 407
Score = 88.9 bits (217), Expect = 1e-16
Identities = 75/268 (27%), Positives = 125/268 (45%), Gaps = 36/268 (13%)
Query: 1 MDVGKLESFIVEKMAERKVPGISISIIKDGDVVYAKGFGYRNVEARLPSTPETIYGIGSI 60
+ + K + + MA + +PG+SI++ DG +V+ GFGY N+E+ T +++ I SI
Sbjct: 37 LKIKKAKELVETTMAIQGIPGLSIAVSLDGKMVWKSGFGYANLESFAKCTGDSVMRIASI 96
Query: 61 TKSFTALAIMKLVEEGGLSLDDPVEK----FVNIKLRPFGEPVTVHHLLTHSSGI----- 111
+K TA + VE G L LD+ + K F K + +T+ LL+HS+GI
Sbjct: 97 SKPITATLAAQCVENGTLDLDEDIRKYLPEFPAKKFKNEDVKITMRQLLSHSAGIRHYAT 156
Query: 112 ----------PSLGYAEA--FIDGMVGGDNWLPVSTPEETIAFARDMEKWAVAKPGERFF 159
PS E F+ P ++ + +A ++ + V KPG +F
Sbjct: 157 EKKKSETHEDPSNNNTETPEFLSNK-------PYNSSLDALAIFKNDD--LVEKPGSKFS 207
Query: 160 YLNTGYVLLGKIIEKVSGVSYEEYIKKKILEPLGM-NRSYFFKEEVEKDKDVAMGYILDK 218
Y G L G ++EK SG +Y + + ++ LGM N KE++ + A Y +
Sbjct: 208 YTTYGLTLAGAVLEKCSGKTYRQ-LANQLFSDLGMRNTQLDTKEKIVPGR--ASYYQRNS 264
Query: 219 EGRL--VPQPFPYGITADGGLLSSVLDL 244
+ L P+ A GG++S+ DL
Sbjct: 265 KNILENCPEVDCSNKFAGGGIISNTTDL 292
>gb|AAF59826.1| (U33634) esterase EstB [Pseudomonas marginata]
Length = 392
Score = 84.3 bits (205), Expect = 3e-15
Identities = 61/212 (28%), Positives = 107/212 (49%), Gaps = 16/212 (7%)
Query: 5 KLESFIVEKMAERKVPGISISIIKDGDVVYAKGFGYRNVEARLPSTPETIYGIGSITKSF 64
+L++ + + ER++ G + + G+++Y + G + EA P +T++ + S+TK
Sbjct: 21 RLDAVFDQALRERRLVGAVAIVARHGEILYRRAQGLADREAGRPMREDTLFRLASVTKPI 80
Query: 65 TALAIMKLVEEGGLSLDDPVEKFV---NIKLRPFGEP-VTVHHLLTHSSGIPSLGYAEAF 120
ALA+++LV G L+LD PV +++ +L EP VT+HHLLTH+SG LGY
Sbjct: 81 VALAVLRLVARGELALDAPVTRWLPEFRPRLADGSEPLVTIHHLLTHTSG---LGY--WL 135
Query: 121 IDGMVGGDNWLPVSTPEETIAFARDMEKWAVAK------PGERFFYLNTGYVLLGKIIEK 174
++G + L +S + F D +A PG + Y + +LG ++E+
Sbjct: 136 LEGAGSVYDRLGISDGIDLRDFDLDENLRRLASAPLSFAPGSGWQY-SLALDVLGAVVER 194
Query: 175 VSGVSYEEYIKKKILEPLGMNRSYFFKEEVEK 206
+G + + +PLGM F E E+
Sbjct: 195 ATGQPLAAAVDALVAQPLGMRDCGFVSAEPER 226
>gb|AAF86698.1|AF180959_1 (AF180959) AMPC cephalosporinase precursor protein ACC-1c [Hafnia
alvei]
Length = 390
Score = 84.3 bits (205), Expect = 3e-15
Identities = 88/355 (24%), Positives = 151/355 (41%), Gaps = 54/355 (15%)
Query: 6 LESFIVEKMAERKVPGISISIIKDGDVVYAKGFGYRNVEARLPSTPETIYGIGSITKSFT 65
++ I M + +PG+S+++ +G Y +G + + P T T++ +GS++K+F
Sbjct: 39 VDDLIQPLMQKNNIPGMSVAVTVNGKN-YIYNYGLAAKQPQQPVTENTLFEVGSLSKTFA 97
Query: 66 ALAIMKLVEEGGLSLDDPVEKFVNIKLRPFGEPVTVHHLLTHSSGIPSLGYAEAFIDGMV 125
A G LSLD V +V + V+V ++ TH+SG+
Sbjct: 98 ATLASYAQVSGKLSLDQSVSHYVPELRGSSFDHVSVLNVGTHTSGLQL------------ 145
Query: 126 GGDNWLPVSTPEETIAFARDMEKWAVAKP-GERFFYLNTGYVLLGKIIEKVSGVSYEEYI 184
++P T A ++ W A G Y N G LLG I K GVSYE+ I
Sbjct: 146 ----FMPEDIKNTTQLMAY-LKAWKPADAAGTHRVYSNIGTGLLGMIAAKSLGVSYEDAI 200
Query: 185 KKKILEPLGMNRSYFFKEEVEKDKDVAMGYILDKEGRLVPQPFPYGITADGGLLSSVLDL 244
+K +L LGM+ SY K ++ ++ A GY +K+ V G+ ++ DL
Sbjct: 201 EKTLLPQLGMHHSY-LKVPADQMENYAWGY--NKKDEPVHVNMEILGNEAYGIKTTSSDL 257
Query: 245 AKYLKM---YIERDESIVSKEYIEKMETSYIKVPWEIFGGEGYGYGLIIYPNFLGEKLVG 301
+Y++ ++ D + ++ + T Y K EI +G + + YP L L G
Sbjct: 258 LRYVQANMGQLKLDANAKMQQALTATHTGYFK-SGEI--TQGLMWEQLPYPVSLPNLLTG 314
Query: 302 H--------------------------SGSVGMYTGYIGYIPEKKIGVAVLENSS 330
+ +GS + YI ++P KK+G+ +L N +
Sbjct: 315 NDMAMTKSVATPIVPPLPPQENVWINKTGSTNGFGAYIAFVPAKKMGIVMLANKN 369
>emb|CAC17625.1| (AJ295343) beta-lactamase class C [Ochrobactrum anthropi]
Length = 390
Score = 83.9 bits (204), Expect = 3e-15
Identities = 86/355 (24%), Positives = 152/355 (42%), Gaps = 64/355 (18%)
Query: 14 MAERKVPGISISIIKDGDVVYAKGFGYRNVEARLPSTPETIYGIGSITKSFTALAIMKLV 73
MAE+K+PG++++I DG + G+G + E+ T +TI+ IGS++K+FTA+ +
Sbjct: 46 MAEQKIPGMAVAITIDGKSHFF-GYGVASKESGQKVTEDTIFEIGSVSKTFTAMLGGYGL 104
Query: 74 EEGGLSLDDPVEKFVNIKLRPFGEPVTVHHLLTHSSGIPSLGYAEAFIDGMVGGDNWLPV 133
G SL DP K+ + +T+ L T++ G L + +A V
Sbjct: 105 ATGAFSLSDPATKWAPELAGSSFDKITMLDLGTYTPGGLPLQFPDA-------------V 151
Query: 134 STPEETIAFARDMEKWAVAKP-GERFFYLNTGYVLLGKIIEKVSGVSYEEYIKKKILEPL 192
+ +A+ +KW P G + Y N L G + + ++ +++K+L
Sbjct: 152 TDDSSMLAY---FKKWRPDYPAGTQHRYSNPSIGLFGYLAARSMDKPFDVLMEQKLLPAF 208
Query: 193 GMNRSYFFKEEVEKDKDVAMGY------ILDKEGRLVPQPFPYGITADGGLLSSVLDLAK 246
G+ ++ E + K+ A GY I G L Q + G+ ++ LDLA+
Sbjct: 209 GLKNTFINVPESQM-KNYAYGYSKANKPIRVSGGTLDAQAY--------GIKTTALDLAR 259
Query: 247 YLKMYIERDESIVSKEYIEKMETSYIKVPWEIFGGEGYGYGLIIYPNFLGEKLVGHS--- 303
++++ I D S + ++ + + ++ +G G+ YP L L G+S
Sbjct: 260 FVELNI--DSSSLEPDFQKAVAATHTGYYHVDANNQGLGWEFYNYPTALKTLLAGNSSDM 317
Query: 304 -------------------------GSVGMYTGYIGYIPEKKIGVAVLENSSGYP 333
GS + Y +IP KKIG+ VL N + YP
Sbjct: 318 ALKSHKIEKFDTPRQPSADVLINKTGSTNGFGAYAAFIPAKKIGIVVLANRN-YP 371
>sp|P15555|DAC_STRSQ D-ALANYL-D-ALANINE CARBOXYPEPTIDASE PRECURSOR (DD-PEPTIDASE)
(DD-CARBOXYPEPTIDASE) >gi|1084263|pir||S48220
serine-type D-Ala-D-Ala carboxypeptidase (EC 3.4.16.4)
precursor - Streptomyces sp >gi|515050|emb|CAA28756.1|
(X05109) DD-peptidase precursor [Streptomyces lividans]
Length = 406
Score = 83.1 bits (202), Expect = 6e-15
Identities = 77/317 (24%), Positives = 140/317 (43%), Gaps = 20/317 (6%)
Query: 20 PGISISIIKDGDV-VYAKGFGYRNVEARLPSTPETIYGIGSITKSFTALAIMKLVEEGGL 78
PG + + +G + ++G R + +T + +GS+TKSF+A+ +++LV+EG L
Sbjct: 55 PGAMVRVDDNGTIHQLSEGVADRATGRAITTTDR--FRVGSVTKSFSAVVLLQLVDEGKL 112
Query: 79 SLDDPVEKFVNIKLRPFGEPVTVHHLLTHSSGIPSLGYAEAFIDGMVGGDNWLPVSTPEE 138
LD V ++ L + +TV +++H SG+ Y V G +
Sbjct: 113 DLDASVNTYLPGLLPD--DRITVRQVMSHRSGL--YDYTNDMFAQTVPGFESVRNKVFSY 168
Query: 139 TIAFARDMEKWAVAKPGERFFYLNTGYVLLGKIIEKVSGVSYEEYIKKKILEPLGMNRSY 198
++ PG + Y NT +V+ G +IEK++G S + +I PL + ++
Sbjct: 169 QDLITLSLKHGVTNAPGAAYSYSNTNFVVAGMLIEKLTGHSVATEYQNRIFTPLNLTDTF 228
Query: 199 FFKEEVEKDKDVAMGYILDKE--GRLV---PQPFPYGITADGGLLSSVLDLAKYLKMYIE 253
+ + A GY+ E G LV Q + +A G ++SS DL +
Sbjct: 229 YVHPDTVIPGTHANGYLTPDEAGGALVDSTEQTVSWAQSA-GAVISSTQDLDTFF----- 282
Query: 254 RDESIVSKEYIEKMETSYIKVPWEIFGGEGYGYGLIIYPNFLGEKLVGHSGSVGMYTGYI 313
+++S + + + + ++ + +GYG GL G + GH+G+V Y Y
Sbjct: 283 --SALMSGQLMSAAQLAQMQQWTTVNSTQGYGLGLRRRDLSCGISVYGHTGTVQGYYTYA 340
Query: 314 GYIPEKKIGVAVLENSS 330
+ K V L N+S
Sbjct: 341 FASKDGKRSVTALANTS 357
>pdb|3PTE| D-Alanyl-D-Alanine CarboxypeptidaseTRANSPEPTIDASE (E.C.3.4.16.4)
>gi|1827703|pdb|1CEG| Cephalothin Complexed With
Dd-Peptidase >gi|1827704|pdb|1CEF| Carboxypeptidase,
Transpeptidase
Length = 349
Score = 83.1 bits (202), Expect = 6e-15
Identities = 77/317 (24%), Positives = 140/317 (43%), Gaps = 20/317 (6%)
Query: 20 PGISISIIKDGDV-VYAKGFGYRNVEARLPSTPETIYGIGSITKSFTALAIMKLVEEGGL 78
PG + + +G + ++G R + +T + +GS+TKSF+A+ +++LV+EG L
Sbjct: 24 PGAMVRVDDNGTIHQLSEGVADRATGRAITTTDR--FRVGSVTKSFSAVVLLQLVDEGKL 81
Query: 79 SLDDPVEKFVNIKLRPFGEPVTVHHLLTHSSGIPSLGYAEAFIDGMVGGDNWLPVSTPEE 138
LD V ++ L + +TV +++H SG+ Y V G +
Sbjct: 82 DLDASVNTYLPGLLPD--DRITVRQVMSHRSGL--YDYTNDMFAQTVPGFESVRNKVFSY 137
Query: 139 TIAFARDMEKWAVAKPGERFFYLNTGYVLLGKIIEKVSGVSYEEYIKKKILEPLGMNRSY 198
++ PG + Y NT +V+ G +IEK++G S + +I PL + ++
Sbjct: 138 QDLITLSLKHGVTNAPGAAYSYSNTNFVVAGMLIEKLTGHSVATEYQNRIFTPLNLTDTF 197
Query: 199 FFKEEVEKDKDVAMGYILDKE--GRLV---PQPFPYGITADGGLLSSVLDLAKYLKMYIE 253
+ + A GY+ E G LV Q + +A G ++SS DL +
Sbjct: 198 YVHPDTVIPGTHANGYLTPDEAGGALVDSTEQTVSWAQSA-GAVISSTQDLDTFF----- 251
Query: 254 RDESIVSKEYIEKMETSYIKVPWEIFGGEGYGYGLIIYPNFLGEKLVGHSGSVGMYTGYI 313
+++S + + + + ++ + +GYG GL G + GH+G+V Y Y
Sbjct: 252 --SALMSGQLMSAAQLAQMQQWTTVNSTQGYGLGLRRRDLSCGISVYGHTGTVQGYYTYA 309
Query: 314 GYIPEKKIGVAVLENSS 330
+ K V L N+S
Sbjct: 310 FASKDGKRSVTALANTS 326
>emb|CAC17624.1| (AJ295342) beta-lactamase class C [Ochrobactrum anthropi]
Length = 390
Score = 82.7 bits (201), Expect = 8e-15
Identities = 85/355 (23%), Positives = 152/355 (41%), Gaps = 64/355 (18%)
Query: 14 MAERKVPGISISIIKDGDVVYAKGFGYRNVEARLPSTPETIYGIGSITKSFTALAIMKLV 73
MAE+K+PG++++I DG + G+G + E+ T +TI+ IGS++K+FTA+ +
Sbjct: 46 MAEQKIPGMAVAITIDGKSHFF-GYGVASKESGQKVTEDTIFEIGSVSKTFTAMLGGYGL 104
Query: 74 EEGGLSLDDPVEKFVNIKLRPFGEPVTVHHLLTHSSGIPSLGYAEAFIDGMVGGDNWLPV 133
G SL DP K+ + +T+ L T++ G L + +A V
Sbjct: 105 ATGAFSLSDPATKWAPELAGSSFDKITMRDLGTYTPGGLPLQFPDA-------------V 151
Query: 134 STPEETIAFARDMEKWAVAKP-GERFFYLNTGYVLLGKIIEKVSGVSYEEYIKKKILEPL 192
+ +A+ +KW P G + Y N L G + + ++ +++K+L
Sbjct: 152 TDDSSMLAY---FKKWKPDYPAGTQRRYSNPSIGLFGYLAARSMDKPFDVLMEQKLLPAF 208
Query: 193 GMNRSYFFKEEVEKDKDVAMGY------ILDKEGRLVPQPFPYGITADGGLLSSVLDLAK 246
G+ ++ F + K+ A GY I G L Q + G+ ++ LDLA+
Sbjct: 209 GL-KNTFINVPASQMKNYAYGYSKANKPIRVSGGALDAQAY--------GIKTTALDLAR 259
Query: 247 YLKMYIERDESIVSKEYIEKMETSYIKVPWEIFGGEGYGYGLIIYPNFLGEKLVGHS--- 303
++++ I D S + ++ + + ++ +G G+ YP L L G+S
Sbjct: 260 FVELNI--DSSSLEPDFQKAVAATHTGYYHVGANNQGLGWEFYNYPTALKTLLAGNSSDM 317
Query: 304 -------------------------GSVGMYTGYIGYIPEKKIGVAVLENSSGYP 333
GS + Y +IP KKIG+ +L N + YP
Sbjct: 318 ALKSHKIEKFDTPRQPSADVLINKTGSTNGFGAYAAFIPAKKIGIVLLANRN-YP 371
>pir||T36443 probable penicillin-binding protein - Streptomyces coelicolor
>gi|5459234|emb|CAB48907.1| (AL096837) putative
penicillin-binding protein [Streptomyces coelicolor
A3(2)]
Length = 359
Score = 82.3 bits (200), Expect = 1e-14
Identities = 65/206 (31%), Positives = 104/206 (49%), Gaps = 12/206 (5%)
Query: 55 YGIGSITKSFTALAIMKLVEEGGLSLDDPVEKFVNIKLRPFGEPVTVHHLLTHSSGIPSL 114
Y IGS +K+F AL + +L+ G ++ +P ++ P PVT+ HL+TH+SG+P+L
Sbjct: 76 YEIGSASKTFAALLLTRLIRRGVVTGAEPAAGCLDPGRTPGPHPVTLAHLITHTSGLPAL 135
Query: 115 GYAEAFIDGMVGGDNWLPVSTPEE--TIAFARDMEKWAVAKPGERFFYLNTGYVLLGKII 172
A G+ P E T AF R K +PG R+ Y N G +LG +
Sbjct: 136 P-AGFLRRGLPAWHTNPYARYPAERLTDAFLRHEPK---HRPGTRWHYSNYGVSVLGHAL 191
Query: 173 EKVSGVSYEEYIKKKILEPLGMNRSYFFKEEVEKDKDVAMGYILDKEGRLVPQPFPY-GI 231
+G ++E+ I ++L LG++ + E E D A+G+ K+GR PF G
Sbjct: 192 AATTGTAWEDLITGQVLRALGLSGTALRAEGPETD---AVGH--RKDGRTPVPPFDAGGF 246
Query: 232 TADGGLLSSVLDLAKYLKMYIERDES 257
A G + S+ DL +L+ +++ D S
Sbjct: 247 QAAGAVRSTPNDLLTFLEAHLDPDRS 272
>emb|CAC17623.1| (AJ295341) beta-lactamase class C [Ochrobactrum anthropi]
Length = 390
Score = 81.9 bits (199), Expect = 1e-14
Identities = 88/358 (24%), Positives = 153/358 (42%), Gaps = 70/358 (19%)
Query: 14 MAERKVPGISISIIKDGDVVYAKGFGYRNVEARLPSTPETIYGIGSITKSFTALAIMKLV 73
MAE+K+PG++++I DG + G+G + E+ T +TI+ IGS++K+FTA+ +
Sbjct: 46 MAEQKIPGMAVAITIDGKSHFF-GYGVASKESGQKVTEDTIFEIGSVSKTFTAMLGGYGL 104
Query: 74 EEGGLSLDDPVEKFVNIKLRPFGEPVTVHHLLTHSSGIPSLGYAEAFIDGMVGGDNWLPV 133
G +L DP K+ + +T+ L T++ G L + +A V
Sbjct: 105 ATGAFTLSDPATKWAPELADSSFDKITMLDLGTYTPGGLPLQFPDA-------------V 151
Query: 134 STPEETIAFARDMEKWAVAKP-GERFFYLNTGYVLLGKIIEKVSGVSYEEYIKKKILEPL 192
S +A+ +KW P G + Y N L G + + ++ +++K+L
Sbjct: 152 SDDSSMLAY---FKKWKPDYPAGTQRRYSNPSIGLFGYLAARSMDKPFDVLMEQKLLPAF 208
Query: 193 GMNRSYFFKEEVEKDKDVAMGY------ILDKEGRLVPQPFPYGITADGGLLSSVLDLAK 246
G+ ++ E + K+ A GY I G L Q + G+ ++ LDLA+
Sbjct: 209 GLKNTFINVPESQM-KNYAYGYSKANKPIRVSGGALDAQAY--------GIKTTALDLAR 259
Query: 247 YLKMYIERDESIVSKEY---IEKMETSYIKVPWEIFGGEGYGYGLIIYPNFLGEKLVGHS 303
++++ I D S + ++ + T Y +V +G G+ YP L L G+S
Sbjct: 260 FVELNI--DSSSLEPDFQKAVAATHTGYYRVD---ANNQGLGWEFYNYPTALKTLLEGNS 314
Query: 304 ----------------------------GSVGMYTGYIGYIPEKKIGVAVLENSSGYP 333
GS + Y +IP KKIG+ +L N + YP
Sbjct: 315 SDMALKSHKIEKFDTPSQPSADVWLNKTGSTNGFGAYAAFIPAKKIGIVLLANRN-YP 371
>emb|CAB46491.1| (AJ133121) AmpC beta-lactamase ACC-1 [Klebsiella pneumoniae]
>gi|6723711|emb|CAB66901.1| (AJ270942) ACC-1
beta-lactamase [Klebsiella pneumoniae]
Length = 386
Score = 81.5 bits (198), Expect = 2e-14
Identities = 87/355 (24%), Positives = 150/355 (41%), Gaps = 54/355 (15%)
Query: 6 LESFIVEKMAERKVPGISISIIKDGDVVYAKGFGYRNVEARLPSTPETIYGIGSITKSFT 65
++ I M + +PG+S+++ +G Y +G + + P T T++ +GS++K+F
Sbjct: 35 VDDLIQPLMQKNNIPGMSVAVTVNGKN-YIYNYGLAAKQPQQPVTENTLFEVGSLSKTFA 93
Query: 66 ALAIMKLVEEGGLSLDDPVEKFVNIKLRPFGEPVTVHHLLTHSSGIPSLGYAEAFIDGMV 125
A G LSLD V +V + V+V ++ TH+SG+
Sbjct: 94 ATLASYAQVSGKLSLDQSVSHYVPELRGSSFDHVSVLNVGTHTSGLQL------------ 141
Query: 126 GGDNWLPVSTPEETIAFARDMEKWAVAKP-GERFFYLNTGYVLLGKIIEKVSGVSYEEYI 184
++P T A ++ W A G Y N G LLG I K GVSYE+ I
Sbjct: 142 ----FMPEDIKNTTQLMAY-LKAWKPADAAGTHRVYSNIGTGLLGMIAAKSLGVSYEDAI 196
Query: 185 KKKILEPLGMNRSYFFKEEVEKDKDVAMGYILDKEGRLVPQPFPYGITADGGLLSSVLDL 244
+K +L LGM+ SY K ++ ++ A GY +K+ V G+ ++ DL
Sbjct: 197 EKTLLPQLGMHHSY-LKVPADQMENYAWGY--NKKDEPVHVNMEILGNEAYGIKTTSSDL 253
Query: 245 AKYLKM---YIERDESIVSKEYIEKMETSYIKVPWEIFGGEGYGYGLIIYPNFLGEKLVG 301
+Y++ ++ D + ++ + T Y K EI + + + YP L L G
Sbjct: 254 LRYVQANMGQLKLDANAKMQQALTATHTGYFK-SGEI--TQDLMWEQLPYPVSLPNLLTG 310
Query: 302 H--------------------------SGSVGMYTGYIGYIPEKKIGVAVLENSS 330
+ +GS + YI ++P KK+G+ +L N +
Sbjct: 311 NDMAMTKSVATPIVPPLPPQENVWINKTGSTNGFGAYIAFVPAKKMGIVMLANKN 365
>gb|AAF86692.1|AF180953_1 (AF180953) AMPC cephalosporinase precursor protein ACC-1a [Hafnia
alvei] >gi|9294820|gb|AAF86693.1|AF180954_1 (AF180954)
AMPC cephalosporinase precursor protein ACC-1a [Hafnia
alvei] >gi|9294832|gb|AAF86699.1|AF180960_1 (AF180960)
AMPC cephalosporinase precursor protein ACC-1a [Hafnia
alvei]
Length = 390
Score = 81.5 bits (198), Expect = 2e-14
Identities = 87/355 (24%), Positives = 150/355 (41%), Gaps = 54/355 (15%)
Query: 6 LESFIVEKMAERKVPGISISIIKDGDVVYAKGFGYRNVEARLPSTPETIYGIGSITKSFT 65
++ I M + +PG+S+++ +G Y +G + + P T T++ +GS++K+F
Sbjct: 39 VDDLIQPLMQKNNIPGMSVAVTVNGKN-YIYNYGLAAKQPQQPVTENTLFEVGSLSKTFA 97
Query: 66 ALAIMKLVEEGGLSLDDPVEKFVNIKLRPFGEPVTVHHLLTHSSGIPSLGYAEAFIDGMV 125
A G LSLD V +V + V+V ++ TH+SG+
Sbjct: 98 ATLASYAQVSGKLSLDQSVSHYVPELRGSSFDHVSVLNVGTHTSGLQL------------ 145
Query: 126 GGDNWLPVSTPEETIAFARDMEKWAVAKP-GERFFYLNTGYVLLGKIIEKVSGVSYEEYI 184
++P T A ++ W A G Y N G LLG I K GVSYE+ I
Sbjct: 146 ----FMPEDIKNTTQLMAY-LKAWKPADAAGTHRVYSNIGTGLLGMIAAKSLGVSYEDAI 200
Query: 185 KKKILEPLGMNRSYFFKEEVEKDKDVAMGYILDKEGRLVPQPFPYGITADGGLLSSVLDL 244
+K +L LGM+ SY K ++ ++ A GY +K+ V G+ ++ DL
Sbjct: 201 EKTLLPQLGMHHSY-LKVPADQMENYAWGY--NKKDEPVHVNMEILGNEAYGIKTTSSDL 257
Query: 245 AKYLKM---YIERDESIVSKEYIEKMETSYIKVPWEIFGGEGYGYGLIIYPNFLGEKLVG 301
+Y++ ++ D + ++ + T Y K EI + + + YP L L G
Sbjct: 258 LRYVQANMGQLKLDANAKMQQALTATHTGYFK-SGEI--TQDLMWEQLPYPVSLPNLLTG 314
Query: 302 H--------------------------SGSVGMYTGYIGYIPEKKIGVAVLENSS 330
+ +GS + YI ++P KK+G+ +L N +
Sbjct: 315 NDMAMTKSVATPIVPPLPPQENVWINKTGSTNGFGAYIAFVPAKKMGIVMLANKN 369
>sp|Q11037|YD67_MYCTU HYPOTHETICAL 41.3 KDA PROTEIN RV1367C >gi|7476744|pir||D70957
hypothetical protein Rv1367c - Mycobacterium
tuberculosis (strain H37RV) >gi|1621249|emb|CAB02645.1|
(Z81011) hypothetical protein Rv1367c [Mycobacterium
tuberculosis]
Length = 377
Score = 81.5 bits (198), Expect = 2e-14
Identities = 75/316 (23%), Positives = 139/316 (43%), Gaps = 60/316 (18%)
Query: 39 GYRNVEARLPSTPETIYGIGSITKSFTALAIMKLVEEGGLSLDDPVEKFVN--------- 89
GYR+++A +P +T++ I S+TK T A M LV+EG L+L DP+ ++
Sbjct: 15 GYRDIDAGVPMQRDTLFRIASMTKPVTVAAAMSLVDEGKLALRDPITRWAPELCKVAVLD 74
Query: 90 ------IKLRPFGEPVTVHHLLTHSSGIPSLGYAEAFIDGMVGGDNWLPVSTPEETIAFA 143
+ P + + LLTH+SG+ + G++ V G P+S + + F
Sbjct: 75 DAAGPLDRTHPARRAILIEDLLTHTSGL-AYGFS-------VSG----PISRAYQRLPFG 122
Query: 144 RDMEKWAVA--------KPGERFFYLNTGYVLLGKIIEKVSGVSYEEYIKKKILEPLGMN 195
+ + W A +PG+R Y + +LG I+ ++ + I +++L P GM
Sbjct: 123 QGPDVWLAALATLPLVHQPGDRVTY-SHAIDVLGVIVSRIEDAPLYQIIDERVLGPAGMT 181
Query: 196 RSYFFKEEVEKDKDVAMGYILDKEGRLVPQPF-------PYGITADGGLLSSVLDLAKYL 248
+ F+ + + A Y LD++ RL P A GGL S+ D +++
Sbjct: 182 DTGFY-VSADAQRRAATMYRLDEQDRLRHDVMGPPHVTPPSFCNAGGGLWSTADDYLRFV 240
Query: 249 KMYIERDE----SIVSKEYIEKMET----------SYIKVPWEIFGGEGYGYGLIIYPNF 294
+M + ++S E + M T S++ P+ + G G+G L + +
Sbjct: 241 RMLLGDGTVDGVRVLSPESVRLMRTDRLTDEQKRHSFLGAPFWV--GRGFGLNLSVVTDP 298
Query: 295 LGEKLVGHSGSVGMYT 310
+ + G +G ++
Sbjct: 299 AKSRPLFGPGGLGTFS 314
>pir||G71680 penicillin-binding protein 4 (pbpE) RP259 - Rickettsia prowazekii
>gi|3860821|emb|CAA14721.1| (AJ235271)
PENICILLIN-BINDING PROTEIN 4* (pbpE) [Rickettsia
prowazekii]
Length = 414
Score = 81.5 bits (198), Expect = 2e-14
Identities = 80/297 (26%), Positives = 135/297 (44%), Gaps = 40/297 (13%)
Query: 57 IGSITKSFTALAIMKLVEEGGLSLDDPVEKFV-----NIKLRPFGEPVTVHHLLTHSSGI 111
I S TK FTA I+KL E+ L+++D + K++ K+ + +++H+LLTHSSGI
Sbjct: 96 IASATKPFTAAGILKLQEQELLNINDKICKYLAPEMWGGKVPDWACKISIHNLLTHSSGI 155
Query: 112 PSLGYAEAFIDGMVGGDNWLPVSTPEETIAFARDMEKWAVAKP-----GERFFYLNTGYV 166
AE F +++ + + + ++ +KP G++F Y NT +V
Sbjct: 156 -----AEYF--------SFVKLDLNMSKQEVHKKILQFVSSKPLEISIGKKFKYSNTNFV 202
Query: 167 LLGKIIEKVSGVSYEEYIKKKILEPLGMNRSYF--FKEEVEKDKDVA-----MGYILDKE 219
+LG IIEKV+ + + +PL M + F + E K+V + Y +
Sbjct: 203 ILGMIIEKVAKKDLANFFYDEFFKPLNMKSTSFASYSEAARIQKNVVSSNYPVRYFVTPN 262
Query: 220 GRLVPQPFPYGI------TADGGLLSSVLDLAKYLKMYIERDESIVSKEYIEKMETSYIK 273
P P ADGG++S+ DL K+ + + I+SK+ + M T Y
Sbjct: 263 NSNKPTFTPVTADFLAVPCADGGIISTPNDLVKWYRAL--NEGKILSKKSYKLMTTKYF- 319
Query: 274 VPWEIFGGEGY-GYGLIIYPNFLGEKLVGHSGSVGMYTGYIGYIPEKKIGVAVLENS 329
V I + Y GYG+ + ++ ++G +GYI I A+L N+
Sbjct: 320 VAQGIESRKSYTGYGIFLTDLDSKHLMIHYTGKALGIQSAVGYILPNNIYFAILSNT 376
>emb|CAC17626.1| (AJ295344) beta-lactamase class C [Ochrobactrum anthropi]
Length = 390
Score = 80.8 bits (196), Expect = 3e-14
Identities = 84/355 (23%), Positives = 151/355 (41%), Gaps = 64/355 (18%)
Query: 14 MAERKVPGISISIIKDGDVVYAKGFGYRNVEARLPSTPETIYGIGSITKSFTALAIMKLV 73
MAE+K+PG++++I DG + G+G + E+ T +TI+ IGS++K+FTA+ +
Sbjct: 46 MAEQKIPGMAVAITIDGKSHFF-GYGVASKESGQKVTEDTIFEIGSVSKTFTAMLGGYGL 104
Query: 74 EEGGLSLDDPVEKFVNIKLRPFGEPVTVHHLLTHSSGIPSLGYAEAFIDGMVGGDNWLPV 133
G SL DP K+ + +T+ L T++ G L + +A V
Sbjct: 105 ATGAFSLSDPATKWAPELAGSSFDKITMRDLGTYTPGGLPLQFPDA-------------V 151
Query: 134 STPEETIAFARDMEKWAVAKP-GERFFYLNTGYVLLGKIIEKVSGVSYEEYIKKKILEPL 192
+ +A+ +KW P G + Y N L G + + ++ +++K+L
Sbjct: 152 TDDSSMLAY---FKKWKPDYPAGTQRRYSNPSIGLFGYLAARSMDKPFDVLMEQKLLPAF 208
Query: 193 GMNRSYFFKEEVEKDKDVAMGY------ILDKEGRLVPQPFPYGITADGGLLSSVLDLAK 246
G+ ++ E + K+ A GY I G L Q + G+ ++ LDLA+
Sbjct: 209 GLKNTFINVPESQM-KNYAYGYSKANKPIRVSGGALDAQAY--------GIKTTALDLAR 259
Query: 247 YLKMYIERDESIVSKEYIEKMETSYIKVPWEIFGGEGYGYGLIIYPNFLGEKLVGHS--- 303
++++ I D S + ++ + + ++ +G G+ YP L L G+S
Sbjct: 260 FVELNI--DSSSLEPDFQKAVAATHTGYYHVGANNQGLGWEFYNYPTALKTLLAGNSSDM 317
Query: 304 -------------------------GSVGMYTGYIGYIPEKKIGVAVLENSSGYP 333
GS + Y +IP KK G+ +L N + YP
Sbjct: 318 ALKSHKIEKFDTPRQPSADVWLNKTGSTNGFGAYAAFIPAKKTGIVLLANRN-YP 371
>emb|CAC17627.1| (AJ295345) beta-lactamase class C [Ochrobactrum anthropi]
Length = 390
Score = 80.8 bits (196), Expect = 3e-14
Identities = 84/355 (23%), Positives = 151/355 (41%), Gaps = 64/355 (18%)
Query: 14 MAERKVPGISISIIKDGDVVYAKGFGYRNVEARLPSTPETIYGIGSITKSFTALAIMKLV 73
MAE+K+PG++++I DG + G+G + E+ T +TI+ IGS++K+FTA+ +
Sbjct: 46 MAEQKIPGMAVAITIDGKSHFF-GYGVASKESGQKVTEDTIFEIGSVSKTFTAMLGGYGL 104
Query: 74 EEGGLSLDDPVEKFVNIKLRPFGEPVTVHHLLTHSSGIPSLGYAEAFIDGMVGGDNWLPV 133
G SL DP K+ + +T+ L T++ G L + +A V
Sbjct: 105 ATGAFSLSDPATKWAPELAGSSFDKITMRDLGTYTPGGLPLQFPDA-------------V 151
Query: 134 STPEETIAFARDMEKWAVAKP-GERFFYLNTGYVLLGKIIEKVSGVSYEEYIKKKILEPL 192
+ +A+ +KW P G + Y N L G + + ++ +++K+L
Sbjct: 152 TDDSSMLAY---FKKWKPDYPAGTQRRYSNPSIGLFGYLAARSMDKPFDVLMEQKLLPAF 208
Query: 193 GMNRSYFFKEEVEKDKDVAMGY------ILDKEGRLVPQPFPYGITADGGLLSSVLDLAK 246
G+ ++ F + K+ A GY I G L Q + G+ ++ LDLA+
Sbjct: 209 GL-KNTFINVPASQMKNYAYGYSKANKPIRVSGGALDAQAY--------GIKTTALDLAR 259
Query: 247 YLKMYIERDESIVSKEYIEKMETSYIKVPWEIFGGEGYGYGLIIYPNFLGEKLVGHS--- 303
++++ I D S + ++ + + ++ +G G+ YP L L G+S
Sbjct: 260 FVELNI--DSSSLEPDFQKAVAATHTGYYHVGANNQGLGWEFYNYPTALKTLLAGNSSDM 317
Query: 304 -------------------------GSVGMYTGYIGYIPEKKIGVAVLENSSGYP 333
GS + Y +IP KK G+ +L N + YP
Sbjct: 318 ALKSHKIEKFDTPRQPSADVWLNKTGSTNGFGAYAAFIPAKKTGIVLLANRN-YP 371
>gb|AAF86694.1|AF180955_1 (AF180955) AMPC cephalosporinase precursor protein ACC-1b [Hafnia
alvei]
Length = 390
Score = 80.4 bits (195), Expect = 4e-14
Identities = 86/355 (24%), Positives = 150/355 (42%), Gaps = 54/355 (15%)
Query: 6 LESFIVEKMAERKVPGISISIIKDGDVVYAKGFGYRNVEARLPSTPETIYGIGSITKSFT 65
++ I M + +PG+S+++ +G Y +G + + P T T++ +GS++K+F
Sbjct: 39 VDDLIQPLMQKNNIPGMSVAVTVNGKN-YIYNYGLAAKQPQQPVTENTLFEVGSLSKTFA 97
Query: 66 ALAIMKLVEEGGLSLDDPVEKFVNIKLRPFGEPVTVHHLLTHSSGIPSLGYAEAFIDGMV 125
A G LSLD V +V + V+V ++ TH+SG+
Sbjct: 98 ATLASYAQVSGKLSLDQSVSHYVPELRGSSFDHVSVLNVGTHTSGLQL------------ 145
Query: 126 GGDNWLPVSTPEETIAFARDMEKWAVAKP-GERFFYLNTGYVLLGKIIEKVSGVSYEEYI 184
++P T A ++ W A G Y N G LLG I K G+SYE+ I
Sbjct: 146 ----FMPEDIKNTTQLMAY-LKAWKPADAAGTHRVYSNIGTGLLGMIAAKSLGMSYEDAI 200
Query: 185 KKKILEPLGMNRSYFFKEEVEKDKDVAMGYILDKEGRLVPQPFPYGITADGGLLSSVLDL 244
+K +L LGM+ SY K ++ ++ A GY +K+ V G+ ++ DL
Sbjct: 201 EKTLLPQLGMHHSY-LKVPADQMENYAWGY--NKKDEPVHVNMEILGNEAYGIKTTSSDL 257
Query: 245 AKYLKM---YIERDESIVSKEYIEKMETSYIKVPWEIFGGEGYGYGLIIYPNFLGEKLVG 301
+Y++ ++ D + ++ + T Y K EI + + + YP L L G
Sbjct: 258 LRYVQANMGQLKLDANAKMQQALTATHTGYFK-SGEI--TQDLMWEQLPYPVSLPNLLTG 314
Query: 302 H--------------------------SGSVGMYTGYIGYIPEKKIGVAVLENSS 330
+ +GS + YI ++P KK+G+ +L N +
Sbjct: 315 NDMAMTKSVATPIVPPLPPQENVWINKTGSTNGFGAYIAFVPAKKMGIVMLANKN 369
>emb|CAC04522.1| (AJ401618) AmpC beta-lactamase class C [Ochrobactrum anthropi]
Length = 390
Score = 80.0 bits (194), Expect = 5e-14
Identities = 84/355 (23%), Positives = 151/355 (41%), Gaps = 64/355 (18%)
Query: 14 MAERKVPGISISIIKDGDVVYAKGFGYRNVEARLPSTPETIYGIGSITKSFTALAIMKLV 73
MAE+K+PG++++I DG + G+G + E+ T +TI+ IGS++K+FTA+ +
Sbjct: 46 MAEQKIPGMAVAITIDGKSHFF-GYGVASKESGQKVTEDTIFEIGSVSKTFTAMLGGYGL 104
Query: 74 EEGGLSLDDPVEKFVNIKLRPFGEPVTVHHLLTHSSGIPSLGYAEAFIDGMVGGDNWLPV 133
G SL DP K+ + +T+ L T++ G L + +A V
Sbjct: 105 ATGAFSLSDPATKWAPELAGSSFDKITMRDLGTYTPGGLPLQFPDA-------------V 151
Query: 134 STPEETIAFARDMEKWAVAKP-GERFFYLNTGYVLLGKIIEKVSGVSYEEYIKKKILEPL 192
+ +A+ +KW P G + Y N L G + + ++ +++K+L
Sbjct: 152 TDDSSMLAY---FKKWKPDYPAGTQRRYSNPSIGLFGYLAARSMDKPFDVLMEQKLLPAF 208
Query: 193 GMNRSYFFKEEVEKDKDVAMGY------ILDKEGRLVPQPFPYGITADGGLLSSVLDLAK 246
G+ ++ F + K+ A GY I G L Q + G+ ++ LDLA+
Sbjct: 209 GL-KNTFINVPASQMKNYAYGYSKANKPIRVSGGALDAQAY--------GIKTTALDLAR 259
Query: 247 YLKMYIERDESIVSKEYIEKMETSYIKVPWEIFGGEGYGYGLIIYPNFLGEKLVGHS--- 303
++++ I D S + ++ + + ++ +G G+ YP L L G+S
Sbjct: 260 FVELNI--DSSSLEPDFQKAVAATHTGYYHVGANNQGLGWEFYNYPTALKTLLEGNSSDM 317
Query: 304 -------------------------GSVGMYTGYIGYIPEKKIGVAVLENSSGYP 333
GS + Y +IP KK G+ +L N + YP
Sbjct: 318 ALKSHKIEKFDTPRQPSADVLINKTGSTNGFGAYAAFIPAKKTGIVLLANRN-YP 371
>pir||A42209 D-stereospecific aminopeptidase (EC 3.4.11.19) - Ochrobactrum
anthropi >gi|10835404|pdb|1EI5|A Chain A, Crystal
Structure Of A D-Aminopeptidase From Ochrobactrum
Anthropi >gi|150443|gb|AAA25519.1| (M84523)
D-aminopeptidase [Ochrobactrum anthropi]
Length = 520
Score = 80.0 bits (194), Expect = 5e-14
Identities = 81/348 (23%), Positives = 155/348 (44%), Gaps = 23/348 (6%)
Query: 2 DVGKLESFIVEKMAERKVPGISISIIKDGDVVYAKGFGYRNVEARLPSTPETIYGIGSIT 61
D LE+F+ K PG ++++KDG+VV +G+ ++ R P T +T I S++
Sbjct: 5 DTSALEAFVRHIPQNYKGPGGVVAVVKDGEVVLQHAWGFADLRTRTPMTLDTRMPICSVS 64
Query: 62 KSFTALAIMKLVEEGGLSLDDPVEKFVNIKLRPFGEPVTVHHLLTHSSGIPSLGYAEAFI 121
K FT ++ V E L LDD +E +++ + E V L + SG+ + +
Sbjct: 65 KQFTCAVLLDAVGEPEL-LDDALEAYLD---KFEDERPAVRDLCNNQSGL-----RDYWA 115
Query: 122 DGMVGGDNWLPVSTPEETIAFARDMEKWAVAKPGERFFYLNTGYVLLGKIIEKVSGVSYE 181
++ G + V P + + R + K +PG + Y N + +L +IE +G +
Sbjct: 116 LSVLCGADPEGVFLPAQAQSLLRRL-KTTHFEPGSHYSYCNGNFRILADLIEAHTGRTLV 174
Query: 182 EYIKKKILEPLGMNRSYFFKEEVEKDKDVAMGYILDKEGRLVPQPFPYGITADGGLLSSV 241
+ + ++I P GM R+ + D+ GY D +P D G+ +S+
Sbjct: 175 DILSERIFAPAGMKRAELISDTALFDE--CTGYEGDTVRGFLPATNRIQWMGDAGICASL 232
Query: 242 LDLAKYLKMYIE--RDESIVSKEYIEKMETSYIKVPWEIFGGEGYGYGLIIYPNFLGEKL 299
D+ + + +I+ RD+ + +T V YG+GL ++ G++L
Sbjct: 233 NDMIAW-EQFIDATRDDESGLYRRLSGPQTFKDGV------AAPYGFGLNLHETG-GKRL 284
Query: 300 VGHSGSVGMYTGYIGYIPEKKIGVAVLENSSGYPPSYIAMYALALLLG 347
GH G++ + + ++++ + N G S +A + + LG
Sbjct: 285 TGHGGALRGWRCQRWHCADERLSTIAMFNFEG-GASEVAFKLMNIALG 331
>pir||S00765 serine-type D-Ala-D-Ala carboxypeptidase (EC 3.4.16.4) precursor -
Streptomyces sp >gi|153448|gb|AAA62239.1| (M26842)
serine DD-peptidase [Streptomyces lividans]
Length = 406
Score = 79.6 bits (193), Expect = 7e-14
Identities = 75/316 (23%), Positives = 137/316 (42%), Gaps = 18/316 (5%)
Query: 20 PGISISIIKDGDV-VYAKGFGYRNVEARLPSTPETIYGIGSITKSFTALAIMKLVEEGGL 78
PG + + +G + ++G R + +T + +GS+TKSF+A+ +++LV+EG L
Sbjct: 55 PGAMVRVDDNGTIHQLSEGVADRATGRAITTTDR--FRVGSVTKSFSAVVLLQLVDEGKL 112
Query: 79 SLDDPVEKFVNIKLRPFGEPVTVHHLLTHSSGIPSLGYAEAFIDGMVGGDNWLPVSTPEE 138
LD V ++ L + +TV +++H SG+ Y V G +
Sbjct: 113 DLDASVNTYLPGLLPD--DRITVRQVMSHRSGL--YDYTNDMFAQTVPGFESVRNKVFSY 168
Query: 139 TIAFARDMEKWAVAKPGERFFYLNTGYVLLGKIIEKVSGVSYEEYIKKKILEPLGMNRSY 198
++ PG + Y NT +V+ G +IEK++G S + +I PL + ++
Sbjct: 169 QDLITLSLKHGVTNAPGAAYSYSNTNFVVAGMLIEKLTGHSVATEYQNRIFTPLNLTDTF 228
Query: 199 FFKEEVEKDKDVAMGYILDKE--GRLVPQPFPYGITADGG--LLSSVLDLAKYLKMYIER 254
+ + A GY+ E G LV A G ++SS DL +
Sbjct: 229 YVHPDTVIPGTHANGYLTPDEAGGALVDSTEQTVSWAQTGAAVISSTQDLDTFF------ 282
Query: 255 DESIVSKEYIEKMETSYIKVPWEIFGGEGYGYGLIIYPNFLGEKLVGHSGSVGMYTGYIG 314
+++S + + + + ++ + +GYG GL G + GH+G+V Y Y
Sbjct: 283 -SALMSGQLMSAAQLAQMQQWTTVNSTQGYGLGLRRRDLSCGISVYGHTGTVQGYYTYAF 341
Query: 315 YIPEKKIGVAVLENSS 330
+ + V L N+S
Sbjct: 342 ASKDGQAHVTALANTS 357
>gb|AAF86695.1|AF180956_1 (AF180956) AMPC cephalosporinase precursor protein ACC-3a [Hafnia
alvei]
Length = 377
Score = 78.8 bits (191), Expect = 1e-13
Identities = 82/367 (22%), Positives = 153/367 (41%), Gaps = 78/367 (21%)
Query: 6 LESFIVEKMAERKVPGISISIIKDG-DVVYAKGFGYRNVEARLPSTPETIYGIGSITKSF 64
++S I M + +PG+S+++ +G D +Y +G + + + P T T++ +GS++K+F
Sbjct: 39 VDSLIQPLMQKNNIPGMSVAVTLNGKDYIY--NYGLASKQPQQPVTDNTLFEVGSLSKTF 96
Query: 65 TALAIMKLVEEGGLSLDDPVEKFVNIKLRPFGEPVTVHHLLTHSSGIPSLGYAEAFIDGM 124
A G LSLD + +V + ++V + TH++G+ E
Sbjct: 97 AATLASYAQVSGKLSLDKSISHYVPELRGSSFDHISVLNAGTHTTGLALFMPEE------ 150
Query: 125 VGGDNWLPVSTPEETIAFARDMEKWAVAKP-GERFFYLNTGYVLLGKIIEKVSGVSYEEY 183
V ++ +A+ ++ W A P G Y N G LLG I + G++YE+
Sbjct: 151 --------VKNTDQLMAY---LKAWKPADPAGTHRVYSNIGTGLLGMIAAQSMGMTYEDA 199
Query: 184 IKKKILEPLGMNRSYFFKEEVEKDKDVAMGYILDKEGRLVPQPFPYGITADG----GLLS 239
I+K +L LGM +Y ++ ++ A GY E P + G G+ +
Sbjct: 200 IEKTLLPKLGMTHTY-LNVPADQAENYAWGYNKKNE------PIHVNMEVLGNEAYGIRT 252
Query: 240 SVLDLAKYLKM---YIERDESIVSKEYIEKMETSYIK-------VPWEIFGGEGYGYGLI 289
+ DL +Y++ ++ D + ++ + Y K + WE +
Sbjct: 253 NASDLIRYVQANMGQLKLDGNSTLQKALTDTHIGYFKSGKITQDLMWE----------QL 302
Query: 290 IYPNFLGEKLVGH--------------------------SGSVGMYTGYIGYIPEKKIGV 323
YP L + L G+ +GS + YI ++P KK+G+
Sbjct: 303 PYPVSLPDLLTGNDMAMTKSVATPIVPPLPPQENVWINKTGSTNGFGAYIAFVPAKKMGI 362
Query: 324 AVLENSS 330
+L N +
Sbjct: 363 VMLANKN 369
>gb|AAF86700.1|AF180961_1 (AF180961) AMPC cephalosporinase precursor protein ACC-1d [Hafnia
alvei]
Length = 390
Score = 78.4 bits (190), Expect = 2e-13
Identities = 86/355 (24%), Positives = 149/355 (41%), Gaps = 54/355 (15%)
Query: 6 LESFIVEKMAERKVPGISISIIKDGDVVYAKGFGYRNVEARLPSTPETIYGIGSITKSFT 65
++ I M + +PG+S+++ +G Y +G + + T T++ +GS++K+F
Sbjct: 39 VDDLIQPLMQKNNIPGMSVAVTVNGKN-YIYNYGLAAKQPQQSVTENTLFEVGSLSKTFA 97
Query: 66 ALAIMKLVEEGGLSLDDPVEKFVNIKLRPFGEPVTVHHLLTHSSGIPSLGYAEAFIDGMV 125
A G LSLD V +V + V+V ++ TH+SG+
Sbjct: 98 ATLASYAQVSGKLSLDQSVSHYVPELRGSSFDHVSVLNVGTHTSGLQL------------ 145
Query: 126 GGDNWLPVSTPEETIAFARDMEKWAVAKP-GERFFYLNTGYVLLGKIIEKVSGVSYEEYI 184
++P T A ++ W A G Y N G LLG I K GVSYE+ I
Sbjct: 146 ----FMPEDIKNTTQLMAY-LKAWKPADAAGTHRVYSNIGTGLLGMIAAKSLGVSYEDAI 200
Query: 185 KKKILEPLGMNRSYFFKEEVEKDKDVAMGYILDKEGRLVPQPFPYGITADGGLLSSVLDL 244
+K +L LGM+ SY K ++ ++ A GY +K+ V G+ ++ DL
Sbjct: 201 EKTLLPQLGMHHSY-LKVPADQMENYAWGY--NKKDEPVHVNMEILGNEAYGIKTTSSDL 257
Query: 245 AKYLKM---YIERDESIVSKEYIEKMETSYIKVPWEIFGGEGYGYGLIIYPNFLGEKLVG 301
+Y++ ++ D + ++ + T Y K EI + + + YP L L G
Sbjct: 258 LRYVQANMGQLKLDANAKMQQALTATHTGYFK-SGEI--TQDLMWEQLPYPVSLPNLLTG 314
Query: 302 H--------------------------SGSVGMYTGYIGYIPEKKIGVAVLENSS 330
+ +GS + YI ++P KK+G+ +L N +
Sbjct: 315 NDMAMTKSVATPIVPPLPPQENVWINKTGSTNGFGAYIAFVPAKKMGIVMLANKN 369
>dbj|BAB16316.1| (AB049588) class C beta-lactamase [Escherichia coli]
Length = 382
Score = 78.4 bits (190), Expect = 2e-13
Identities = 84/358 (23%), Positives = 149/358 (41%), Gaps = 58/358 (16%)
Query: 6 LESFIVEKMAERKVPGISISIIKDGDVVYAKGFGYRNVEARLPSTPETIYGIGSITKSFT 65
+++ I + E ++PG++++++KDG Y +G N E+ + +T++ IGS++K+ T
Sbjct: 36 VDASIQPLLKEHRIPGMAVAVLKDGKAHYFN-YGVANRESGASVSEQTLFDIGSVSKTLT 94
Query: 66 ALAIMKLVEEGGLSLDDPVEKFVNIKLRPFGEPVTVHHLLTHSSGIPSLGYAEAFIDGMV 125
A V +G + LDD + + +T+ L T+S+G L + E
Sbjct: 95 ATLGAYAVVKGAMQLDDKASRHAPWLKGSVFDSITMGELATYSAGGLPLQFPE------- 147
Query: 126 GGDNWLPVSTPEETIAFARDMEKWA-VAKPGERFFYLNTGYVLLGKIIEKVSGVSYEEYI 184
V + E+ A+ R +WA V PG Y N L G + + + +
Sbjct: 148 ------EVDSSEKMRAYYR---QWAPVYSPGSHRQYSNPSIGLFGHLAASSLKQPFAQLM 198
Query: 185 KKKILEPLGMNRSYFFKEEVEKDKDVAMGYILDKEGRLVPQPFPYGITADG--GLLSSVL 242
++ +L LGM+ +Y V K + Y KE + P G+ AD G+ +S
Sbjct: 199 EQTLLPGLGMHHTYV---NVPKQAMASYAYGYSKEDK--PIRVNPGMLADEAYGIKTSSA 253
Query: 243 DLAKYLKMYIERDESIVSKEYIEKMETSYIKVPWEIFGG--EGYGYGLIIYPNFLGEKLV 300
DL ++K I + ++ I + V GG +G G+ YP L
Sbjct: 254 DLLAFVKANIGGVDDKALQQAISLTHKGHYSV-----GGMTQGLGWESYAYPVTEQTLLA 308
Query: 301 GHS-------------------------GSVGMYTGYIGYIPEKKIGVAVLENSSGYP 333
G+S GS + Y+ ++P + IG+ +L N + YP
Sbjct: 309 GNSAKVILEANPTAAPRESGSQVLFNKTGSTNGFGAYVAFVPARGIGIVMLANRN-YP 365
>gb|AAF86696.1|AF180957_1 (AF180957) AMPC cephalosporinase precursor protein ACC-3 [Hafnia
alvei] >gi|9294828|gb|AAF86697.1|AF180958_1 (AF180958)
AMPC cephalosporinase precursor protein ACC-3 [Hafnia
alvei]
Length = 377
Score = 78.0 bits (189), Expect = 2e-13
Identities = 81/366 (22%), Positives = 151/366 (41%), Gaps = 76/366 (20%)
Query: 6 LESFIVEKMAERKVPGISISIIKDGDVVYAKGFGYRNVEARLPSTPETIYGIGSITKSFT 65
++S I M + +PG+S+++ +G Y +G + + + P T T++ +GS++K+F
Sbjct: 39 VDSLIQPLMQKNNIPGMSVAVTLNGKN-YIYNYGLASKQPQQPVTDNTLFEVGSLSKTFA 97
Query: 66 ALAIMKLVEEGGLSLDDPVEKFVNIKLRPFGEPVTVHHLLTHSSGIPSLGYAEAFIDGMV 125
A G LSLD + +V + ++V + TH++G+ E
Sbjct: 98 ATLASYAQVSGKLSLDKSISHYVPELRGSSFDHISVLNAGTHTTGLALFMPEE------- 150
Query: 126 GGDNWLPVSTPEETIAFARDMEKWAVAKP-GERFFYLNTGYVLLGKIIEKVSGVSYEEYI 184
V ++ +A+ ++ W A P G Y N G LLG I + G++YE+ I
Sbjct: 151 -------VKNTDQLMAY---LKAWKPADPAGTHRVYSNIGTGLLGMIAAQSMGMTYEDAI 200
Query: 185 KKKILEPLGMNRSYFFKEEVEKDKDVAMGYILDKEGRLVPQPFPYGITADG----GLLSS 240
+K +L LGM +Y ++ ++ A GY E P + G G+ ++
Sbjct: 201 EKTLLPKLGMTHTY-LNVPADQAENYAWGYNKKNE------PIHVNMEVLGNEAYGIRTN 253
Query: 241 VLDLAKYLKM---YIERDESIVSKEYIEKMETSYIK-------VPWEIFGGEGYGYGLII 290
DL +Y++ ++ D + ++ + Y K + WE +
Sbjct: 254 ASDLIRYVQANMGQLKLDGNSTLQKALTDTHIGYFKSGKITQDLMWE----------QLP 303
Query: 291 YPNFLGEKLVGH--------------------------SGSVGMYTGYIGYIPEKKIGVA 324
YP L + L G+ +GS + YI ++P KK+G+
Sbjct: 304 YPVSLPDLLTGNDMAMTKSVATPIVPPLPPQENVWINKTGSTNGFGAYIAFVPAKKMGIV 363
Query: 325 VLENSS 330
+L N +
Sbjct: 364 MLANKN 369
>gb|AAF86691.1|AF180952_3 (AF180952) AMPC cephalosporinase ACC-2 [Hafnia alvei]
Length = 390
Score = 78.0 bits (189), Expect = 2e-13
Identities = 87/359 (24%), Positives = 153/359 (42%), Gaps = 62/359 (17%)
Query: 6 LESFIVEKMAERKVPGISISI-IKDGDVVYAKGFGYRNVEARLPSTPETIYGIGSITKSF 64
++ I M + +PG+S+++ I+ + +Y +G + + P T T++ +GS++K+F
Sbjct: 39 VDGLIQPLMQKNNIPGMSVAVTIRGRNYIY--NYGLAAKQPQQPVTENTLFEVGSLSKTF 96
Query: 65 TALAIMKLVEEGGLSLDDPVEKFVNIKLRPFGEPVTVHHLLTHSSGIPSLGYAEAFIDGM 124
A+ G LSL+ V +V + V+V ++ TH+SG
Sbjct: 97 AAILASYAQASGKLSLEQSVSHYVPELRGSSFDHVSVLNVGTHTSG-------------- 142
Query: 125 VGGDNWLPVSTPEE---TIAFARDMEKWAVAKP-GERFFYLNTGYVLLGKIIEKVSGVSY 180
L + PE+ T ++ W A G Y N G LLG I K GVSY
Sbjct: 143 ------LQLFMPEDIKNTTQLMTYLKAWKPADAAGTHRVYSNIGTGLLGMIAAKSLGVSY 196
Query: 181 EEYIKKKILEPLGMNRSYFFKEEVEKDKDVAMGYILDKEGRLVPQPFPYGITADGGLLSS 240
E+ I++ IL LGMN++Y K ++ ++ A GY +K+ V G+ ++
Sbjct: 197 EDAIEQTILPLLGMNQTY-LKVPADQMENYAWGY--NKKDEPVHVNMEILGNEAYGIKTT 253
Query: 241 VLDLAKYLKM---YIERDESIVSKEYIEKMETSYIKVPWEIFGGEGYGYGLIIYPNFLGE 297
DL +Y++ ++ D + + + T Y K EI + + + YP L
Sbjct: 254 SSDLLRYVQANMGQLKLDGNAKIQHALTATHTGYFK-SGEI--TQDLMWEQLPYPVSLPN 310
Query: 298 KLVGH--------------------------SGSVGMYTGYIGYIPEKKIGVAVLENSS 330
L G+ +GS + YI ++P KK+G+ +L N +
Sbjct: 311 LLTGNDMAMTKSVATPIVPPLPPQENVWINKTGSTNGFGAYIAFVPAKKMGIVMLANKN 369
>gb|AAD50818.2|AF167990_1 (AF167990) AmpC-type class C beta-lactamase [Klebsiella pneumoniae]
Length = 382
Score = 78.0 bits (189), Expect = 2e-13
Identities = 84/358 (23%), Positives = 149/358 (41%), Gaps = 58/358 (16%)
Query: 6 LESFIVEKMAERKVPGISISIIKDGDVVYAKGFGYRNVEARLPSTPETIYGIGSITKSFT 65
+++ I + E ++PG++++++KDG Y +G N E+ + +T++ IGS++K+ T
Sbjct: 36 VDASIQPLLKEHRIPGMAVAVLKDGKAHYFN-YGVANRESGASVSEQTLFEIGSVSKTLT 94
Query: 66 ALAIMKLVEEGGLSLDDPVEKFVNIKLRPFGEPVTVHHLLTHSSGIPSLGYAEAFIDGMV 125
A V +G + LDD + + +T+ L T+S+G L + E
Sbjct: 95 ATLGAYAVVKGAMQLDDKASRHAPWLKGSVFDSITMGELATYSAGGLPLQFPE------- 147
Query: 126 GGDNWLPVSTPEETIAFARDMEKWA-VAKPGERFFYLNTGYVLLGKIIEKVSGVSYEEYI 184
V + E+ A+ R +WA V PG Y N L G + + + +
Sbjct: 148 ------EVDSSEKMRAYYR---QWAPVYSPGSHRQYSNPSIGLFGHLAASSLKQPFAQLM 198
Query: 185 KKKILEPLGMNRSYFFKEEVEKDKDVAMGYILDKEGRLVPQPFPYGITADG--GLLSSVL 242
++ +L LGM+ +Y V K + Y KE + P G+ AD G+ +S
Sbjct: 199 EQTLLPGLGMHHTYV---NVPKQAMASYAYGYSKEDK--PIRVNPGMLADEAYGIKTSSA 253
Query: 243 DLAKYLKMYIERDESIVSKEYIEKMETSYIKVPWEIFGG--EGYGYGLIIYPNFLGEKLV 300
DL ++K I + ++ I + V GG +G G+ YP L
Sbjct: 254 DLLAFVKANIGGVDDKALQQAISLTHKGHYSV-----GGMTQGLGWESYAYPVTEQTLLA 308
Query: 301 GHS-------------------------GSVGMYTGYIGYIPEKKIGVAVLENSSGYP 333
G+S GS + Y+ ++P + IG+ +L N + YP
Sbjct: 309 GNSAKVILEANPTAAPRESGSQVLFNKTGSTNGFGAYVAFVPARGIGIVMLANRN-YP 365
>emb|CAC17149.1| (AJ299421) cephalosporinase [Ochrobactrum anthropi]
Length = 390
Score = 77.6 bits (188), Expect = 3e-13
Identities = 83/355 (23%), Positives = 150/355 (41%), Gaps = 64/355 (18%)
Query: 14 MAERKVPGISISIIKDGDVVYAKGFGYRNVEARLPSTPETIYGIGSITKSFTALAIMKLV 73
MAE+K+PG++++I DG+ + G+G + E+ T TI+ IGS++K+FTA+ +
Sbjct: 46 MAEQKIPGMAVAITIDGNSHFF-GYGVASKESGQKVTEHTIFEIGSVSKTFTAMLGGYGL 104
Query: 74 EEGGLSLDDPVEKFVNIKLRPFGEPVTVHHLLTHSSGIPSLGYAEAFIDGMVGGDNWLPV 133
G SL DP K+ + +T+ L T++ G L + +A V
Sbjct: 105 ATGAFSLSDPATKWAPELAGSSFDKITMLDLGTYTPGGLPLQFPDA-------------V 151
Query: 134 STPEETIAFARDMEKWAVAKP-GERFFYLNTGYVLLGKIIEKVSGVSYEEYIKKKILEPL 192
+ +A+ + W P G + Y N L G + + ++ +++K+L
Sbjct: 152 TDDSSMLAY---FKNWKPDYPAGTQRRYSNPSIGLFGYLAARSMDKPFDVLMEQKLLPAF 208
Query: 193 GMNRSYFFKEEVEKDKDVAMGY------ILDKEGRLVPQPFPYGITADGGLLSSVLDLAK 246
G+ ++ E + K+ A GY I G L Q + G+ ++ LDLA+
Sbjct: 209 GLKNTFINVPESQM-KNYAYGYSKANKPIRVSGGALDAQAY--------GIKTTALDLAR 259
Query: 247 YLKMYIERDESIVSKEYIEKMETSYIKVPWEIFGGEGYGYGLIIYPNFLGEKLVGHS--- 303
++++ I D S + ++ + + ++ +G G+ YP L L G+S
Sbjct: 260 FVELNI--DSSSLEPDFQKAVAATHTGYYHVGANNQGLGWEFYNYPTALKTLLAGNSSDM 317
Query: 304 -------------------------GSVGMYTGYIGYIPEKKIGVAVLENSSGYP 333
GS + Y +IP KK G+ +L N + YP
Sbjct: 318 ALKSHKIEKFDTPRQPSADVWLNKTGSTNGFGAYAAFIPAKKTGIVLLANRN-YP 371
>emb|CAC17622.1| (AJ295340) beta-lactamase class C [Ochrobactrum anthropi]
Length = 390
Score = 77.3 bits (187), Expect = 3e-13
Identities = 83/355 (23%), Positives = 150/355 (41%), Gaps = 64/355 (18%)
Query: 14 MAERKVPGISISIIKDGDVVYAKGFGYRNVEARLPSTPETIYGIGSITKSFTALAIMKLV 73
MAE+K+PG++++I DG + G+G + E+ T +TI+ IGS++K+FTA+ +
Sbjct: 46 MAEQKIPGMAVAITIDGKSHFF-GYGVASKESGQKVTEDTIFEIGSVSKTFTAMLGGYGL 104
Query: 74 EEGGLSLDDPVEKFVNIKLRPFGEPVTVHHLLTHSSGIPSLGYAEAFIDGMVGGDNWLPV 133
G SL DP K+ + +T+ L T++ G L + +A V
Sbjct: 105 ATGAFSLSDPATKWAPELAGSSFDKITMLDLGTYTPGGLPLQFPDA-------------V 151
Query: 134 STPEETIAFARDMEKWAVAKP-GERFFYLNTGYVLLGKIIEKVSGVSYEEYIKKKILEPL 192
+ +A+ + W P G + Y N L G + + ++ +++K+L
Sbjct: 152 TDDSSMLAY---FKNWKPDYPAGTQRRYSNPSIGLFGYLAARSMDKPFDVLMEQKLLPAF 208
Query: 193 GMNRSYFFKEEVEKDKDVAMGY------ILDKEGRLVPQPFPYGITADGGLLSSVLDLAK 246
G+ ++ E + K+ A GY I G L Q + G+ ++ LDLA+
Sbjct: 209 GLKNTFINVPESQM-KNYAYGYSKANKPIRVSGGALDAQAY--------GIKTTALDLAR 259
Query: 247 YLKMYIERDESIVSKEYIEKMETSYIKVPWEIFGGEGYGYGLIIYPNFLGEKLVGHS--- 303
++++ I D S + ++ + + ++ +G G+ YP L L G+S
Sbjct: 260 FVELNI--DSSSLELDFQKAVAATHTGYYHVGANNQGLGWEFYNYPTALKTLLAGNSSDM 317
Query: 304 -------------------------GSVGMYTGYIGYIPEKKIGVAVLENSSGYP 333
GS + Y +IP KK G+ +L N + YP
Sbjct: 318 ALKSHKIEKFDTPRQPSADVWLNKTGSTNGFGAYAAFIPAKKTGIVLLANRN-YP 371
>dbj|BAA23130.1| (AB008454) SRT-1 [Serratia marcescens]
Length = 378
Score = 77.3 bits (187), Expect = 3e-13
Identities = 86/352 (24%), Positives = 155/352 (43%), Gaps = 52/352 (14%)
Query: 6 LESFIVEKMAERKVPGISISIIKDG-DVVYAKGFGYRNVEARLPSTPETIYGIGSITKSF 64
+++ I M + VPG++I++ DG +Y +G + + P T +T++ +GS++K+F
Sbjct: 28 IDAVIQPLMKKYGVPGMAIAVSVDGKQQIYP--YGVASKQTGKPITEQTLFEVGSLSKTF 85
Query: 65 TALAIMKLVEEGGLSLDDPVEKFVNIKLRPFGEPVTVHHLLTHSSGIPSLGYAEAFIDGM 124
TA + ++G LS +DP +++ + V++ +L TH+SG+P F+
Sbjct: 86 TATLAVYAQQQGKLSFNDPASRYLPELRGSAFDGVSLLNLATHTSGLP------LFVPDD 139
Query: 125 VGGDNWLPVSTPEETIAFARDMEKWAVAKP-GERFFYLNTGYVLLGKIIEKVSGVSYEEY 183
V D + +A+ R W P G Y N G V+LG I K + +
Sbjct: 140 VTND--------AQLMAYYR---AWQPKHPAGSYRVYSNLGIVMLGMIAAKSLDQPFIQA 188
Query: 184 IKKKILEPLGMNRSYFFKEEVEKDKDVAMGYIL-DKEGRLVPQPFPYGITADGGLLSSVL 242
+++ +L LGM+ +Y + + + A GY DK R+ P P G+ S+
Sbjct: 189 MEQGMLPALGMSHTY-VQVPAAQMANYAQGYSKDDKPVRVNPGPLD---AKSYGIKSNAR 244
Query: 243 DLAKYLKMYIERDE-SIVSKEYIEKMETSYIK-------VPWEIFGG--------EGYGY 286
DL +YL +++ + + ++ + Y K + WE + EG
Sbjct: 245 DLIRYLDANLQQVKVAHAWRDALAATHVGYYKAGAFTQDLMWENYPYPVKLSRLIEGNNA 304
Query: 287 GLIIYPN----------FLGEKLVGHSGSVGMYTGYIGYIPEKKIGVAVLEN 328
G+I+ L +GS G ++ Y +IP K I V +L N
Sbjct: 305 GMIMNGTPATAITPPQPELRAGWYNKTGSTGGFSTYAVFIPAKNIAVVMLAN 356
>emb|CAA63264.1| (X92508) ES-beta-lactamase [Klebsiella pneumoniae]
Length = 382
Score = 77.3 bits (187), Expect = 3e-13
Identities = 84/358 (23%), Positives = 149/358 (41%), Gaps = 58/358 (16%)
Query: 6 LESFIVEKMAERKVPGISISIIKDGDVVYAKGFGYRNVEARLPSTPETIYGIGSITKSFT 65
+++ I + E ++PG++++++KDG Y +G N E+ + +T++ IGS++K+ T
Sbjct: 36 VDASIQPLLKEHRIPGMAVAVLKDGKAHYFN-YGVANRESGAGVSEQTLFEIGSVSKTLT 94
Query: 66 ALAIMKLVEEGGLSLDDPVEKFVNIKLRPFGEPVTVHHLLTHSSGIPSLGYAEAFIDGMV 125
A V +G + LDD + + +T+ L T+S+G L + E
Sbjct: 95 ATLGAYAVVKGAMQLDDKASRHAPWLKGSAFDSITMGELATYSAGGLPLQFPE------- 147
Query: 126 GGDNWLPVSTPEETIAFARDMEKWA-VAKPGERFFYLNTGYVLLGKIIEKVSGVSYEEYI 184
V + E+ A+ R +WA V PG Y N L G + + +
Sbjct: 148 ------EVDSSEKMRAYYR---QWAPVYSPGSHRQYSNPSIGLFGHLAASSLKQPFAPLM 198
Query: 185 KKKILEPLGMNRSYFFKEEVEKDKDVAMGYILDKEGRLVPQPFPYGITADG--GLLSSVL 242
++ +L LGM+ +Y V K + Y KE + P G+ AD G+ +S
Sbjct: 199 EQTLLPGLGMHHTYV---NVPKQAMASYAYGYSKEDK--PIRVNPGMLADEAYGIKTSSA 253
Query: 243 DLAKYLKMYIERDESIVSKEYIEKMETSYIKVPWEIFGG--EGYGYGLIIYPNFLGEKLV 300
DL +++K I + ++ I + V GG +G G+ YP L
Sbjct: 254 DLLRFVKANIGGVDDKALQQAISLTHQGHYSV-----GGMTQGLGWESYAYPVTEQTLLA 308
Query: 301 GHS-------------------------GSVGMYTGYIGYIPEKKIGVAVLENSSGYP 333
G+S GS + Y+ ++P + IG+ +L N + YP
Sbjct: 309 GNSAKVILEANPTAAPRESGSQVLFNKTGSTNGFGAYVAFVPARGIGIVMLANRN-YP 365
>pir||S41941 beta-lactamase, class C - Klebsiella pneumoniae
>gi|453215|emb|CAA54602.1| (X77455) beta-lactamase,
class C [Klebsiella pneumoniae]
Length = 382
Score = 76.9 bits (186), Expect = 4e-13
Identities = 84/360 (23%), Positives = 144/360 (39%), Gaps = 59/360 (16%)
Query: 6 LESFIVEKMAERKVPGISISIIKDGDVVYAKGFGYRNVEARLPSTPETIYGIGSITKSFT 65
++ I + E ++PG++++++KDG Y +G N E+ + +T++ IGS++K+ T
Sbjct: 33 VDGIIQPMLKEYRIPGMAVAVLKDGKAHYFN-YGVANRESGQRVSEQTLFEIGSVSKTLT 91
Query: 66 ALAIMKLVEEGGLSLDDPVEKFVNIKLRPFGEPVTVHHLLTHSSGIPSLGYAEAFIDGMV 125
A +GG LDD V + + VT+ L T+S+G
Sbjct: 92 ATLGAYAAVKGGFELDDKVSQHAPWLKGSAFDGVTMAELATYSAG--------------- 136
Query: 126 GGDNWLPVSTPEETIA---FARDMEKWAVAKP-GERFFYLNTGYVLLGKIIEKVSGVSYE 181
LP+ P+E + W+ P G Y N L G + G +E
Sbjct: 137 ----GLPLQFPDEVDSNDKMRTYYRHWSPVYPAGTHRQYSNPSIGLFGHLAANSLGQPFE 192
Query: 182 EYIKKKILEPLGMNRSYFFKEEVEKDKDVAMGYIL-DKEGRLVPQPFPYGITADG--GLL 238
+ + + +L LG++ +Y E + A GY DK R+ P G+ A G+
Sbjct: 193 QLMSQTLLPKLGLHHTYIQVPE-SAIANYAYGYSKEDKPVRVTP-----GVLAAEAYGIK 246
Query: 239 SSVLDLAKYLKMYIERDESIVSKEYIEKMETSYIKV--PWEIFGGEGYGYGL-------- 288
+ DL K+ + + K I T + V + G E Y Y L
Sbjct: 247 TGSADLLKFTEANMGYQGDAALKTRIALTHTGFYSVGDMTQGLGWESYAYPLTEQALLAG 306
Query: 289 --------------IIYPNFLGE-KLVGHSGSVGMYTGYIGYIPEKKIGVAVLENSSGYP 333
P +GE +L +GS G + Y+ ++P + I + +L N + YP
Sbjct: 307 NSPAVSFQANPVTRFAVPKAMGEQRLYNKTGSTGGFGAYVAFVPARGIAIVMLANRN-YP 365
>emb|CAA71325.1| (Y10282) ES-beta-lactamase [Escherichia coli]
Length = 382
Score = 75.7 bits (183), Expect = 1e-12
Identities = 83/360 (23%), Positives = 144/360 (39%), Gaps = 59/360 (16%)
Query: 6 LESFIVEKMAERKVPGISISIIKDGDVVYAKGFGYRNVEARLPSTPETIYGIGSITKSFT 65
++ I + E ++PG++++++KDG Y +G N E+ + +T++ IGS++K+ T
Sbjct: 33 VDGIIQPMLKEYRIPGMAVAVLKDGKAHYFN-YGVANRESGQRVSEQTLFEIGSVSKTLT 91
Query: 66 ALAIMKLVEEGGLSLDDPVEKFVNIKLRPFGEPVTVHHLLTHSSGIPSLGYAEAFIDGMV 125
A +GG LDD V + VT+ L T+S+G
Sbjct: 92 ATLGAYAAVKGGFELDDKVSHHAPWLKGSAFDGVTMAELATYSAG--------------- 136
Query: 126 GGDNWLPVSTPEETIA---FARDMEKWAVAKP-GERFFYLNTGYVLLGKIIEKVSGVSYE 181
LP+ P+E + W+ P G Y N L G + G +E
Sbjct: 137 ----GLPLQFPDEVDSNDKMQTYYRSWSPVYPAGTHRQYSNPSIGLFGHLAANSLGQPFE 192
Query: 182 EYIKKKILEPLGMNRSYFFKEEVEKDKDVAMGYIL-DKEGRLVPQPFPYGITADG--GLL 238
+ + + +L LG++ +Y E + A GY DK R+ P G+ A G+
Sbjct: 193 KLMSQTLLPKLGLHHTYIQVPE-SAMANYAYGYSKEDKPIRVTP-----GVLAAEAYGIK 246
Query: 239 SSVLDLAKYLKMYIERDESIVSKEYIEKMETSYIKV--PWEIFGGEGYGYGL-------- 288
+ DL K+++ + K I T + V + G E Y Y +
Sbjct: 247 TGSADLLKFVEANMGYQGDAALKSAIALTHTGFYSVGDMTQGLGWESYAYPVTEQALLAG 306
Query: 289 --------------IIYPNFLGE-KLVGHSGSVGMYTGYIGYIPEKKIGVAVLENSSGYP 333
P +GE +L +GS G + Y+ ++P + I + +L N + YP
Sbjct: 307 NSPAVSFQANPVTRFAVPKAMGEQRLYNKTGSTGGFGAYVAFVPARGIAIVMLANRN-YP 365
>sp|P45460|AMPC_YEREN BETA-LACTAMASE PRECURSOR (CEPHALOSPORINASE) >gi|477836|pir||B48899
beta-lactamase (EC 3.5.2.6) - Yersinia enterocolitica
>gi|48563|emb|CAA44850.1| (X63149) beta-lactamase
[Yersinia enterocolitica]
Length = 388
Score = 75.3 bits (182), Expect = 1e-12
Identities = 78/360 (21%), Positives = 162/360 (44%), Gaps = 72/360 (20%)
Query: 14 MAERKVPGISISIIKDGDVVYAKGFGYRNVEARLPSTPETIYGIGSITKSFTALAIMKLV 73
+ ++ +PG+++++ DG + +G +++A P T T++ +GS++K+FT +A +
Sbjct: 45 LEKQGIPGMAVAVFYDGKPQFFN-YGMADIKAGRPVTENTLFELGSVSKTFTGVAGEYAM 103
Query: 74 EEGGLSLDDPVEKFVNIKLRPFGEPVTVHHLLTHSSGIPSLGYAEAFIDGMVGGDNWLPV 133
+ G ++L+DPV ++ + V + HL T+++G LP+
Sbjct: 104 QTGIMNLNDPVTEYAPELTGSQWKDVKMLHLATYTAG-------------------GLPL 144
Query: 134 STPEETI-------AFARDMEKWAVAKPGERFFYLNTGYVLLGKIIEKVSGVSYEEYIKK 186
P+ + + +WA PG Y N L G + K S +++E Y+K+
Sbjct: 145 QLPDSVTDQKSLWQYYQQWQPQWA---PGVMRNYSNASIGLFGALAVKRSQLTFENYMKE 201
Query: 187 KILEPLGMNRSYFFKEEVEKDKDVAMGYILDKEGRLVPQPFPYGITADG--GLLSSVLDL 244
+ +PL ++ ++ E + A GY K+G+ P G+ + G+ S+ D+
Sbjct: 202 YVFQPLKLDHTFITIPE-SMQSNYAWGY---KDGQ--PVRVTLGMLGEEAYGVKSTSQDM 255
Query: 245 AKYLKMYIERDESIVS-----KEYIEKMETSYIKVPWEIFGGEGY--------------- 284
++++ ++ ES+ + KE I ++ Y + ++F G G+
Sbjct: 256 VRFMQANMD-PESLPAGNDKLKEAIIASQSRYFQA-GDMFQGLGWEMYSWPINPQGVIAD 313
Query: 285 -GYGLIIYPN----------FLGEKLVGHSGSVGMYTGYIGYIPEKKIGVAVLENSSGYP 333
G + + P + V +G+ + YI +IPE+K+G+ +L N + YP
Sbjct: 314 SGNDIALKPRKVEALVPAQPAVRASWVHKTGATNGFGAYIVFIPEEKVGIVMLANKN-YP 372
>gb|AAG12974.1| (AY007369) beta-lactamase FOX-5 [Klebsiella pneumoniae]
Length = 382
Score = 75.3 bits (182), Expect = 1e-12
Identities = 80/358 (22%), Positives = 144/358 (39%), Gaps = 55/358 (15%)
Query: 6 LESFIVEKMAERKVPGISISIIKDGDVVYAKGFGYRNVEARLPSTPETIYGIGSITKSFT 65
++ I + ++PG++++++KDG Y +G N E+ + +T++ IGS++K+ T
Sbjct: 33 VDGIIQPMLKAYRIPGMAVAVLKDGKAHYFN-YGVANRESGQRVSEQTLFEIGSVSKTLT 91
Query: 66 ALAIMKLVEEGGLSLDDPVEKFVNIKLRPFGEPVTVHHLLTHSSGIPSLGYAEAFIDGMV 125
A +GG LDD V + + VT+ L T+S+G
Sbjct: 92 ATLGAYAAVKGGFELDDKVSQHAPWLKGSALDGVTMAELATYSAG--------------- 136
Query: 126 GGDNWLPVSTPEETIA---FARDMEKWAVAKP-GERFFYLNTGYVLLGKIIEKVSGVSYE 181
LP+ P+E + W+ P G Y N L G + G +E
Sbjct: 137 ----GLPLQFPDEVDSNDKMRTYYRSWSPVYPAGTHRQYSNPSIGLFGHLAANSLGQPFE 192
Query: 182 EYIKKKILEPLGMNRSYFFKEEVEKDKDVAMGYILDKEGRLVPQPFPYGITADG-GLLSS 240
+ + + +L LG++ +Y +V + V Y KE + V + P + A+ G+ +
Sbjct: 193 QLMSQTLLPKLGLHHTYI---QVPESAMVNYAYGYSKEDKPV-RVTPGVLAAEAYGIKTG 248
Query: 241 VLDLAKYLKMYIERDESIVSKEYIEKMETSYIKV--PWEIFGGEGYGYGL---------- 288
DL K+ + + K I T + V + G E Y Y +
Sbjct: 249 SADLLKFAEANMGYQGDAAVKSAIALTHTGFYSVGDMTQGLGWESYAYPVTEQTLLAGNA 308
Query: 289 ------------IIYPNFLGE-KLVGHSGSVGMYTGYIGYIPEKKIGVAVLENSSGYP 333
P +GE +L +GS G + Y+ ++P + I + +L N + YP
Sbjct: 309 PAVSFQANPVTRFAVPKAMGEQRLYNKTGSTGGFGAYVAFVPARGIAIVMLANRN-YP 365
>emb|CAA71947.1| (Y11068) beta-lactamase class C [Klebsiella oxytoca]
Length = 382
Score = 74.9 bits (181), Expect = 2e-12
Identities = 84/357 (23%), Positives = 143/357 (39%), Gaps = 53/357 (14%)
Query: 6 LESFIVEKMAERKVPGISISIIKDGDVVYAKGFGYRNVEARLPSTPETIYGIGSITKSFT 65
++ I + E ++PGI+++++KDG Y +G N E+ + +T++ IGS++K+ T
Sbjct: 33 VDGIIQPMLKEYRIPGIAVAVLKDGKAHYFN-YGVANRESGQRVSEQTLFEIGSVSKTLT 91
Query: 66 ALAIMKLVEEGGLSLDDPVEKFVNIKLRPFGEPVTVHHLLTHSSGIPSLGYAEAFIDGMV 125
A +GG LDD V + + VT+ L T+S+G G F D +
Sbjct: 92 ATLGAYAAVKGGFVLDDKVSQHAPWLKGSALDGVTMAELATYSAG----GLPLQFPDKVD 147
Query: 126 GGDNWLPVSTPEETIAFARDMEKWAVAKP-GERFFYLNTGYVLLGKIIEKVSGVSYEEYI 184
D W+ P G Y N L G + G +E+ +
Sbjct: 148 SNDK------------MQTYYRSWSPVYPAGTHRQYSNPSIGLFGHLAANSLGQPFEQLM 195
Query: 185 KKKILEPLGMNRSYFFKEEVEKDKDVAMGYIL-DKEGRLVPQPFPYGITADG--GLLSSV 241
+ +L LG++ +Y E + A GY DK R+ P G+ A G+ +
Sbjct: 196 SQTLLPKLGLHHTYIQVPE-SAMANYAYGYSKEDKPIRVTP-----GVLAAEAYGIKTGS 249
Query: 242 LDLAKYLKMYIERDESIVSKEYIEKMETSYIKV--PWEIFGGEGYGYGL----------- 288
DL K+ + + + K I T + V + G E Y Y +
Sbjct: 250 ADLLKFAEANMGYQGDALVKSAIALTHTGFYSVGEMTQGLGWESYDYPVTEQVLLAGNSP 309
Query: 289 -----------IIYPNFLGE-KLVGHSGSVGMYTGYIGYIPEKKIGVAVLENSSGYP 333
P +GE +L +GS G + Y+ ++P + I + +L N + YP
Sbjct: 310 AVSFQANPVTRFAVPKAMGEQRLYNKTGSTGGFGAYVAFVPARGIAIVMLANRN-YP 365
>emb|CAB94057.1| (AL358672) putative secreted protein. [Streptomyces coelicolor
A3(2)]
Length = 597
Score = 74.9 bits (181), Expect = 2e-12
Identities = 68/292 (23%), Positives = 130/292 (44%), Gaps = 55/292 (18%)
Query: 44 EARLPSTPETIYGIGSITKSFTALAIMKLVEEGGLSLDDPVEKFVNIKLRPFGEPVTVHH 103
+ ++P T T++ + SI+K FT++ ++ +E G L L PV ++ R + +T+ H
Sbjct: 129 DEQIPMTGGTVFDLASISKLFTSILAVQQLERGALELATPVASYLPDFGRAGKQNMTIRH 188
Query: 104 LLTHSSGIPSLGYAEAFIDGMVGGDNWLPV---STPEETIAFARDMEKWAVAKPGERFFY 160
LLTH+SG + W+P+ T EE + D + V+ PG + Y
Sbjct: 189 LLTHTSGFRA----------------WIPLYSAPTYEEKVQLVYD--EAPVSAPGTAYLY 230
Query: 161 LNTGYVLLGKIIEKVSGVSYEEYIKKKILEPLGMNRSYF-----------FKEEVEK--- 206
+ + L ++E+V+G + + ++++I +PLG+ R+ + E+ K
Sbjct: 231 SDLNMISLQLVLEEVTGRTLDVLLREEITKPLGLTRTRYNPPASWRPGIAATEDARKPWS 290
Query: 207 --DKDVAMGYILDKEGRLVPQPFPYGITADGGLLSSVLDLAKYLKMYIERDE----SIVS 260
D+ + G + D+ + G+ G+ S DLA + + I+
Sbjct: 291 GLDRGLVWGEVHDENAFSLG-----GVAGHAGVFSCAWDLAVLGRTLLNGGSYGRARILR 345
Query: 261 KEYIEKMETSYIKVPWEIFGGEGYGYGLIIYPN-FLG----EKLVGHSGSVG 307
E +E M T + F G+ +G G +Y + ++G + GH+G G
Sbjct: 346 PESVELMFTDFN----TDFPGDEHGLGFELYQHWYMGAMATPRTAGHTGFTG 393
>dbj|BAA23131.1| (AB008455) SST-1 [Serratia marcescens]
Length = 378
Score = 74.5 bits (180), Expect = 2e-12
Identities = 84/355 (23%), Positives = 152/355 (42%), Gaps = 58/355 (16%)
Query: 6 LESFIVEKMAERKVPGISISIIKDG-DVVYAKGFGYRNVEARLPSTPETIYGIGSITKSF 64
+++ I M + VPG++I++ DG +Y +G + + P T +T++ +GS++K+F
Sbjct: 28 IDAVIQPLMKKYGVPGMAIAVSVDGKQQIYP--YGVASKQTGKPITEQTLFEVGSLSKTF 85
Query: 65 TALAIMKLVEEGGLSLDDPVEKFVNIKLRPFGEPVTVHHLLTHSSGIPSLGYAEAFIDGM 124
TA + ++G LS +DP +++ + V++ +L TH+SG
Sbjct: 86 TATLAVYAQQQGKLSFNDPASRYLPELRGSAFDGVSLLNLATHTSG-------------- 131
Query: 125 VGGDNWLPVSTPEETIAFARDMEKWAVAKP----GERFFYLNTGYVLLGKIIEKVSGVSY 180
LP+ P++ A+ M + +P G Y N G +LG I K +
Sbjct: 132 ------LPLFVPDDVTDNAQLMAYYRAWQPKHPAGSYRVYSNLGIGMLGMIAAKSLDQPF 185
Query: 181 EEYIKKKILEPLGMNRSYFFKEEVEKDKDVAMGYIL-DKEGRLVPQPFPYGITADGGLLS 239
+ +++ +L LGM +Y + + + A GY DK R+ P P G+ S
Sbjct: 186 TQAMEQGMLPALGMRHTY-VQVPAAQMANYAQGYNKDDKPVRVNPGPLD---AESYGIKS 241
Query: 240 SVLDLAKYLKMYIERDE-SIVSKEYIEKMETSYIK-------VPWEIFGG--------EG 283
+ DL +YL +++ + + +E + Y K + WE + EG
Sbjct: 242 NARDLIRYLDANLQQVKVAHAWREALTATHVGYYKAGAFTQDLMWENYPYPVKLSRLIEG 301
Query: 284 YGYGLIIYPN----------FLGEKLVGHSGSVGMYTGYIGYIPEKKIGVAVLEN 328
G+I+ L +GS G ++ Y +IP K I V +L N
Sbjct: 302 NNAGMIMNGTPATAITPPQPELRAGWYNKTGSTGGFSTYAVFIPAKNIAVVMLAN 356
>pir||S76446 hypothetical protein - Synechocystis sp. (strain PCC 6803)
>gi|1653663|dbj|BAA18575.1| (D90915) D-alanyl-D-alanine
carboxypeptidase [Synechocystis sp.]
Length = 400
Score = 74.5 bits (180), Expect = 2e-12
Identities = 84/358 (23%), Positives = 156/358 (43%), Gaps = 50/358 (13%)
Query: 5 KLESFIVEKMAERKVPGISISI-----IKDGDV-VYAKGFGYRNVEARLPSTP----ETI 54
K+++ + E R+ P +I + DGD+ Y G ++ P++P +++
Sbjct: 30 KVQTILDEHYQNRREPEFFSAIQLSTKVGDGDIKTYVVG-----TKSHAPNSPPIDAKSL 84
Query: 55 YGIGSITKSFTALAIMKLVEEGGLSLDDPVEKFVNIKLRPFGEPVTVHHLLTHSSGIPSL 114
+ IGSITKSFT++ +++ E ++L D + + VT+ LL +SG+P+
Sbjct: 85 FQIGSITKSFTSVLLLQAEAENKVNLGDDFTTY--LPEYDHWNGVTITQLLNMTSGLPNY 142
Query: 115 GYAEAFIDGMVGGDNWLPVSTPEETIAFARDMEKWAVAKPGERFFYLNTGYVLLGKIIEK 174
+ G V + +E + + Y NT Y L G ++EK
Sbjct: 143 SDSPTLNYGFVQSPE--RIWQDKELVDVVYPQPNLPAPPLNTGYAYTNTAYTLGGLVLEK 200
Query: 175 VSGVSYEEYIKKKILEPLGMNRSYFFKEEVEKDKDVAMGYILDK--EG---------RLV 223
V G SY E I KK+L+PL +N +++ D ILD+ EG L
Sbjct: 201 VYGQSYAELIDKKLLQPLELNNTFYPIPSYPPD-------ILDRMVEGSSFNPYTNPELA 253
Query: 224 PQPFPYG----ITADGGLLSSVLDLAKYLKMYIERDESIVSKEYIEKMETSYIKVPWEIF 279
+P G A GGL+++ D+ +++ D+ ++S E ++ + ++
Sbjct: 254 GKPVANGNLSWAGAAGGLVANTEDIINWVRALFVEDQ-LLSTEQKTQLTRLVSLITGKLI 312
Query: 280 GG------EGYGYGLII-YPNFLGEKLVGHSGSVGMYTGYIGYIPEKKIGVAVLENSS 330
G G+G G++ Y G+ ++G + Y+ Y P ++ ++ L NS+
Sbjct: 313 DGTTSEEQRGFGLGVVQGYHEDWGQYWFYQGETIGHRSFYL-YFPCNEVIISALFNSA 369
>emb|CAB82578.1| (AJ276453) beta-lactamase [Klebsiella pneumoniae]
Length = 382
Score = 74.5 bits (180), Expect = 2e-12
Identities = 80/353 (22%), Positives = 141/353 (39%), Gaps = 64/353 (18%)
Query: 14 MAERKVPGISISIIKDGDVVYAKGFGYRNVEARLPSTPETIYGIGSITKSFTALAIMKLV 73
+ E ++PG++++++KDG Y +G + E + + +T++ IGS++K TA V
Sbjct: 44 LKEHRIPGMAVAVLKDGKAHYFN-YGVADRERAVGVSEQTLFEIGSVSKPLTATLGAYAV 102
Query: 74 EEGGLSLDDPVEKFVNIKLRPFGEPVTVHHLLTHSSGIPSLGYAEAFIDGMVGGDNWLPV 133
+G + LDD + + +T+ L T+S+G LP+
Sbjct: 103 VKGAMQLDDKASRHAPWLKGSAFDSITMGELATYSAG-------------------GLPL 143
Query: 134 STPEETIAFARDM---EKWAVA-KPGERFFYLNTGYVLLGKIIEKVSGVSYEEYIKKKIL 189
PEE + + +W A PG Y N L G + + + +++ +L
Sbjct: 144 QFPEEVDSLEKMQAYYRQWTPAYSPGSHRQYSNPSIGLFGHLAASSMKQPFAQLMEQTLL 203
Query: 190 EPLGMNRSYFFKEEVEKDKDVAMGYILDKEGRLVPQPFPYGITADG--GLLSSVLDLAKY 247
LG++ +Y V K + Y KE + P G+ AD G+ +S DL ++
Sbjct: 204 PGLGLHHTYV---NVPKQAMASYAYGYSKEDK--PIRVSPGMLADEAYGIKTSSADLLRF 258
Query: 248 LKMYIERDESIVSKEYIEKMETSYIKVPWEIFGG--EGYGYGLIIYPNFLGEKLVGHS-- 303
+K I ++ I + V GG +G G+ YP L G+S
Sbjct: 259 VKANISGVHDKALQQAISLTHKGHYSV-----GGMTQGLGWESYAYPVSEQTLLAGNSAK 313
Query: 304 -----------------------GSVGMYTGYIGYIPEKKIGVAVLENSSGYP 333
GS + Y+ ++P K IG+ +L N + YP
Sbjct: 314 VILEANPTAAPRESGSQMLFNKTGSTSGFGAYVAFVPAKGIGIVMLANRN-YP 365
>sp|O69773|AMPC_PROST BETA-LACTAMASE PRECURSOR (CEPHALOSPORINASE)
>gi|3164111|emb|CAA76739.1| (Y17315) beta-lactamase
class C [Providencia stuartii]
Length = 384
Score = 74.1 bits (179), Expect = 3e-12
Identities = 84/358 (23%), Positives = 159/358 (43%), Gaps = 62/358 (17%)
Query: 5 KLESFIVEKMAERKVPGISISIIKDG-DVVYAKGFGYRNVEARLPSTPETIYGIGSITKS 63
+++ I M + ++PG+S++I +G +Y +G ++ + ++P + T+Y IGS++K+
Sbjct: 34 EVDDIIKPLMKQEQIPGMSVAISVNGKQAIYH--YGVQSKQTQIPVSDRTLYEIGSLSKT 91
Query: 64 FTALAIMKLVEEGGLSLDDPVEKFVNIKLRPFGEPVTVHHLLTHSSGIPSLGYAEAFIDG 123
FTA +G L V ++ + V+V +L TH+SG+ F+
Sbjct: 92 FTATLATYAQIQGKLDFSQSVSHYLPELKGSAFDNVSVMNLATHTSGL------SLFVPS 145
Query: 124 MVGGDNWLPVSTPEETIAFARDMEKWAV-AKPGERFFYLNTGYVLLGKIIEKVSGVSYEE 182
+ T ++ +A+ +KW + G+ Y N G LLG + K + + +
Sbjct: 146 --------DIKTNDQLMAY---YQKWLPDNEVGQYRSYSNLGVGLLGIVTAKQLNMPFSQ 194
Query: 183 YIKKKILEPLGMNRSYFFKEEVEKDKDVAMGYILDKEGRLVPQPFPYGITADG----GLL 238
++K +L LG+ +Y + ++K A GY +K+ QP + G GL
Sbjct: 195 AMEKLMLPSLGLKHTYIHVPK-SQEKYYAQGY--NKQN----QPVRLNLEILGPEAYGLK 247
Query: 239 SSVLDLAKYLKMYIERDESIVSKEYIEKMETSYIKV---------------PW-----EI 278
S+ DL +YL++ ++ + V+K + E +E ++ V PW ++
Sbjct: 248 SNAKDLIRYLEINMQSIK--VAKTWQEAIENTHTGVYLTDSFVQDMMWESYPWPVSLSQL 305
Query: 279 FGGEGYGYGL------IIYPNFLGE--KLVGHSGSVGMYTGYIGYIPEKKIGVAVLEN 328
G L +I P E +GS + Y +IPE+KI + +L N
Sbjct: 306 LQGNRDDMALKPQKVELIKPAMAPEVRAYYNKTGSSNGFATYAIFIPEEKIAIVMLSN 363
>emb|CAB69829.1| (AJ271368) class C beta-lactamase [Serratia marcescens]
Length = 378
Score = 73.7 bits (178), Expect = 4e-12
Identities = 83/357 (23%), Positives = 155/357 (43%), Gaps = 62/357 (17%)
Query: 6 LESFIVEKMAERKVPGISISIIKDG-DVVYAKGFGYRNVEARLPSTPETIYGIGSITKSF 64
+++ I M + VPG++I++ DG +Y +G + + P T +T++ +GS++K+F
Sbjct: 28 IDAVIQPLMKKYGVPGMAIAVSVDGKQQIYP--YGVASKQTGKPITEQTLFEVGSLSKTF 85
Query: 65 TALAIMKLVEEGGLSLDDPVEKFVNIKLRPFGEPVTVHHLLTHSSGIPSLGYAEAFIDGM 124
TA + ++G LS DP +++ + V++ +L TH+SG
Sbjct: 86 TATLAVYAQQQGKLSFKDPASRYLPELRGSAFDGVSLLNLATHTSG-------------- 131
Query: 125 VGGDNWLPVSTPEETIAFARDMEKWAVAKP----GERFFYLNTGYVLLGKIIEKVSGVSY 180
LP+ P++ A+ M + +P G Y N G +LG I K +
Sbjct: 132 ------LPLFVPDDVTDNAQLMAYYRAWQPKHPAGSYRVYSNLGIGMLGMIAAKSLDQPF 185
Query: 181 EEYIKKKILEPLGMNRSYFFKEEVEKDKDVAMGYIL-DKEGRLVPQPFPYGITADGGLLS 239
+ +++ +L LGM+ +Y + + + A GY DK R+ P P G+ S
Sbjct: 186 IQAMEQGMLPALGMSHTY-VQVPAAQMANYAQGYSKDDKPVRVNPGPLD---AESYGIKS 241
Query: 240 SVLDLAKYLKMYIERDESIVSKEYIEKMETSYI----------KVPWEIFG--------G 281
+ DL +YL +++ + V++ + E + +++ + WE +
Sbjct: 242 NARDLIRYLDANLQQVK--VAQPWREALAATHVGYYKAGAFTQDLMWENYPYPVKLSRLV 299
Query: 282 EGYGYGLIIYPN----------FLGEKLVGHSGSVGMYTGYIGYIPEKKIGVAVLEN 328
EG G+I+ L +GS G ++ Y +IP K I V +L N
Sbjct: 300 EGNNAGMIMNGTPATAITPPQPELRAGWYNKTGSTGGFSTYAVFIPAKNIAVVMLAN 356
>emb|CAB89086.1| (AJ277535) beta-lactamase class C [Escherichia coli]
Length = 382
Score = 73.7 bits (178), Expect = 4e-12
Identities = 78/358 (21%), Positives = 144/358 (39%), Gaps = 55/358 (15%)
Query: 6 LESFIVEKMAERKVPGISISIIKDGDVVYAKGFGYRNVEARLPSTPETIYGIGSITKSFT 65
++ I + ++PG++++++KDG Y +G N E+ + +T++ IGS++K+ T
Sbjct: 33 VDGIIQPMLKAYRIPGMAVAVLKDGKAHYFN-YGVANRESGQRVSEQTLFEIGSVSKTLT 91
Query: 66 ALAIMKLVEEGGLSLDDPVEKFVNIKLRPFGEPVTVHHLLTHSSGIPSLGYAEAFIDGMV 125
A +GG LDD V + + VT+ L T+S+G
Sbjct: 92 ATLGAYAAVKGGFELDDKVSQHAPWLKGSAFDGVTMAELATYSAG--------------- 136
Query: 126 GGDNWLPVSTPEETIA---FARDMEKWAVAKP-GERFFYLNTGYVLLGKIIEKVSGVSYE 181
LP+ P+E + W+ P G Y N L G + G +E
Sbjct: 137 ----GLPLQFPDEVDSNDKMQTYYRSWSPVYPAGTHRQYSNPSIGLFGHLAANSLGQPFE 192
Query: 182 EYIKKKILEPLGMNRSYFFKEEVEKDKDVAMGYILDKEGRLVPQPFPYGITADG-GLLSS 240
+ + + +L LG++ +Y +V + Y KE + + + P + A+ G+ +
Sbjct: 193 QLMSQTLLPKLGLHHTYI---QVPESAMANYAYGYSKEDKPI-RATPGVLAAEAYGIKTG 248
Query: 241 VLDLAKYLKMYIERDESIVSKEYIEKMETSYIKV--PWEIFGGEGYGYGL---------- 288
DL K+++ + K I T + V + G E Y Y +
Sbjct: 249 SADLLKFVEANMGYQGDAALKSAIALTHTGFHSVGEMTQGLGWESYDYPVTEQVLLAGNS 308
Query: 289 ------------IIYPNFLGE-KLVGHSGSVGMYTGYIGYIPEKKIGVAVLENSSGYP 333
P +GE +L +GS G + Y+ ++P + I + +L N + YP
Sbjct: 309 PAVSFQANPVTRFAVPKAMGEQRLYNKTGSTGGFGAYVAFVPARGIAIVMLANRN-YP 365
>emb|CAB77444.1| (AJ009979) beta-lactamase class C [Acinetobacter baumannii]
Length = 383
Score = 71.4 bits (172), Expect = 2e-11
Identities = 77/338 (22%), Positives = 152/338 (44%), Gaps = 52/338 (15%)
Query: 19 VPGISISIIKDGDVVYAKGFGYRNVEARLPSTPETIYGIGSITKSFTALAIMKLVEEGGL 78
VPG+++ +I++ Y +G ++V+ + TI+ +GS++K FTA A +G +
Sbjct: 49 VPGMAVGVIQNNKK-YEMYYGLQSVQDKKAVNSSTIFELGSVSKLFTATAGGYAKNKGKI 107
Query: 79 SLDD-PVEKFVNIKLRPFGEPVTVHHLLTHSSGIPSLGYAEAFIDGMVGGDNWLPVSTPE 137
S DD P + + +K P + V + L T++SG +L + + V T +
Sbjct: 108 SFDDTPGKYWKELKNTPI-DQVNLLQLATYTSGNLALQFPD-------------EVKTDQ 153
Query: 138 ETIAFARDMEKWAVAKP----GERFFYLNTGYVLLGKIIEKVSGVSYEEYIKKKILEPLG 193
+ + F +D W KP GE Y N L GK++ +++ ++K I LG
Sbjct: 154 QVLTFFKD---W---KPKNSIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPALG 207
Query: 194 MNRSYFFKEEVEKDKDVAMGYILDKEGRLVPQPFPYGITADGGLLSSVLDLAKYLKMYI- 252
+ SY + + ++ A GY + + V P P G A G+ S++ D+ ++ +
Sbjct: 208 LKHSYVNVPKTQM-QNYAFGYNQENQPIRV-NPGPLGAPA-YGVKSTLPDMLSFIHANLN 264
Query: 253 -ERDESIVSKEYIEKMETSY-IKVPWEIFGGEGYGY-------------GLIIYPNFL-- 295
++ + + + E + Y + ++ G E + Y +++ PN +
Sbjct: 265 PQKYPADIQRAINETHQGRYQVNTMYQALGWEEFSYPATLQTLLDSNSEQIVMKPNKVTA 324
Query: 296 -----GEKLVGHSGSVGMYTGYIGYIPEKKIGVAVLEN 328
K+ +GS + Y+ +IP++ IG+ +L N
Sbjct: 325 ISKEPSVKMYHKTGSTNRFGTYVVFIPKENIGLVMLTN 362
>pir||E65017 hypothetical protein b2430 - Escherichia coli (strain K-12)
>gi|1788770|gb|AAC75483.1| (AE000330) putative
beta-lactamase [Escherichia coli K12]
>gi|1799860|dbj|BAA16314.1| (D90872) BETA-LACTAMASE
PRECURSOR (EC 3.5.2.6) (CEPHALOSPORINASE). [Escherichia
coli] >gi|1799864|dbj|BAA16317.1| (D90873)
BETA-LACTAMASE PRECURSOR (EC 3.5.2.6)
(CEPHALOSPORINASE). [Escherichia coli]
Length = 463
Score = 71.0 bits (171), Expect = 3e-11
Identities = 57/203 (28%), Positives = 90/203 (44%), Gaps = 39/203 (19%)
Query: 20 PGISISIIKDGDVVYAKGFGYRN-------VEARLPSTPETIYGIGSITKSF-TALAIMK 71
P +++ IIKD +VY K +G +E + +T T+Y + S TK + T A+ K
Sbjct: 85 PSVNLLIIKDNQIVYRKAWGAAKKYDGSVLMEQPVKATTGTLYDLASNTKMYATNFALQK 144
Query: 72 LVEEGGLSLDDPVEKFV---------NIKLRPFGEPVTVHHLLTHSSGIPS------LGY 116
L+ EG L DD + K++ IK + + + LL HS G P+
Sbjct: 145 LMSEGKLHPDDRIAKYIPGFADSPNDTIKGK---NTLRISDLLHHSGGFPADPQYPNKAV 201
Query: 117 AEAFIDGMVGGDNWLPVSTPEETIAFARDMEKWAVAKPGERFFYLNTGYVLLGKIIEKVS 176
A A G + TP E +PG + Y + Y+LLG I+E V+
Sbjct: 202 AGALYSQDKGQTLEMIKRTPLEY-------------QPGSKHIYSDVDYMLLGFIVESVT 248
Query: 177 GVSYEEYIKKKILEPLGMNRSYF 199
G + Y+++ I PLG+ + F
Sbjct: 249 GQPLDRYVEESIYRPLGLTHTVF 271
>sp|P77619|YFEW_ECOLI HYPOTHETICAL 47.8 KDA PROTEIN IN UCPA-AMIA INTERGENIC REGION
PRECURSOR
Length = 434
Score = 71.0 bits (171), Expect = 3e-11
Identities = 57/203 (28%), Positives = 90/203 (44%), Gaps = 39/203 (19%)
Query: 20 PGISISIIKDGDVVYAKGFGYRN-------VEARLPSTPETIYGIGSITKSF-TALAIMK 71
P +++ IIKD +VY K +G +E + +T T+Y + S TK + T A+ K
Sbjct: 56 PSVNLLIIKDNQIVYRKAWGAAKKYDGSVLMEQPVKATTGTLYDLASNTKMYATNFALQK 115
Query: 72 LVEEGGLSLDDPVEKFV---------NIKLRPFGEPVTVHHLLTHSSGIPS------LGY 116
L+ EG L DD + K++ IK + + + LL HS G P+
Sbjct: 116 LMSEGKLHPDDRIAKYIPGFADSPNDTIKGK---NTLRISDLLHHSGGFPADPQYPNKAV 172
Query: 117 AEAFIDGMVGGDNWLPVSTPEETIAFARDMEKWAVAKPGERFFYLNTGYVLLGKIIEKVS 176
A A G + TP E +PG + Y + Y+LLG I+E V+
Sbjct: 173 AGALYSQDKGQTLEMIKRTPLEY-------------QPGSKHIYSDVDYMLLGFIVESVT 219
Query: 177 GVSYEEYIKKKILEPLGMNRSYF 199
G + Y+++ I PLG+ + F
Sbjct: 220 GQPLDRYVEESIYRPLGLTHTVF 242
Database: ./suso.pep
Posted date: Jul 6, 2001 5:57 PM
Number of letters in database: 840,471
Number of sequences in database: 2977
Database: /banques/blast2/nr.pep
Posted date: Dec 14, 2000 12:46 PM
Number of letters in database: 188,266,275
Number of sequences in database: 595,510
Lambda K H
0.319 0.142 0.414
Gapped
Lambda K H
0.270 0.0470 0.230
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 182363820
Number of Sequences: 2977
Number of extensions: 8704797
Number of successful extensions: 18843
Number of sequences better than 1.0e-10: 112
Number of HSP's better than 0.0 without gapping: 5
Number of HSP's successfully gapped in prelim test: 107
Number of HSP's that attempted gapping in prelim test: 18594
Number of HSP's gapped (non-prelim): 168
length of query: 447
length of database: 189,106,746
effective HSP length: 55
effective length of query: 392
effective length of database: 156,189,961
effective search space: 61226464712
effective search space used: 61226464712
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 41 (21.7 bits)
S2: 166 (69.1 bits)