BLASTP 2.0.10 [Aug-26-1999] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= PAB0190 (PAB0190) DE:ATP-dependent RNA helicase, EIF-4A FAMILY (752 letters) Database: ./suso.pep; /banques/blast2/nr.pep 598,487 sequences; 189,106,746 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value pir||D75219 ATP-dependent RNA helicase, eif-4a family PAB0190 - ... 1465 0.0 pir||D71203 probable ATP-dependent RNA helicase - Pyrococcus hor... 1146 0.0 gi|11499053 ATP-dependent RNA helicase, putative [Archaeoglobus ... 699 0.0 pir||E69055 ATP-dependent RNA helicase, eIF-4A family - Methanob... 611 e-173 pir||H64487 eIF-4A family probable ATP-dependent RNA helicase ho... 608 e-173 sp|Q58900|YF05_METJA PUTATIVE ATP-DEPENDENT RNA HELICASE MJ1505 ... 607 e-172 gb|AAG20456.1| (AE005118) ATP-dependent RNA helicase homolog eIF... 548 e-155 emb|CAC12619.1| (AL445067) RNA helicase (RIG-I) related protein ... 342 6e-93 gb|AAC62691.1| (AF083071) ATP-dependent RNA helicase [Cenarchaeu... 303 6e-81 pir||T31323 ATP-dependent RNA helicase, eIF-4A family - Cenarcha... 294 2e-78 pir||T39190 probable ATP-dependent RNA helicase - fission yeast ... 242 1e-62 gb|AAF55897.1| (AE003735) CG7922 gene product [Drosophila melano... 235 2e-60 gb|AAF79368.1|AC007887_27 (AC007887) F15O4.40 [Arabidopsis thali... 205 2e-51 gi|6322192 Mph1p [Saccharomyces cerevisiae] >gi|731905|sp|P40562... 192 1e-47 pir||C71203 probable DNA excision repair protein - Pyrococcus ho... 157 4e-37 gi|7657516 RNA helicase [Homo sapiens] >gi|4405795|gb|AAD19826.1... 155 2e-36 pir||C72622 hypothetical protein APE1436 - Aeropyrum pernix (str... 153 8e-36 gi|11545922 melanoma differentiation associated protein-5 [Homo ... 143 9e-33 gb|AAK41026.1| RNA helicase (ATP dependent)/eIF4A (eiF4A) [Sulfo... 141 3e-32 emb|CAB57574.1| (Y18930) ATP-dependent RNA helicase, eIF-4A fami... 141 3e-32 gb|AAG09428.1|AF181119_1 (AF181119) RNA helicase [Sus scrofa] 132 1e-29 dbj|BAB13818.1| (AK021416) unnamed protein product [Homo sapiens] 131 2e-29 gi|11499994 DNA repair protein, putative [Archaeoglobus fulgidus... 119 1e-25 sp|Q09884|YC9A_SCHPO HYPOTHETICAL HELICASE C584.10C IN CHROMOSOM... 113 6e-24 pir||T32534 hypothetical protein F15B10.2 - Caenorhabditis elega... 111 2e-23 gi|4885217 excision repair cross-complementing rodent repair def... 98 5e-19 sp|Q92889|XPF_HUMAN DNA-REPAIR PROTEIN COMPLEMENTING XP-F CELL (... 98 5e-19 gb|AAB07689.1| (U64315) DNA repair endonuclease subunit [Homo sa... 95 3e-18 dbj|BAA89229.1| (AB017635) ERCC4 [Cricetulus griseus] 91 5e-17 gb|AAC03240.1| (AC004155) ERCC4_MOUSE [Mus musculus] 89 2e-16 gi|7657064 excision repair cross-complementing rodent repair def... 89 2e-16 pir||T46312 hypothetical protein DKFZp434J1111.1 - human (fragme... 87 5e-16 gi|11526480 RNA helicase [Homo sapiens] 86 1e-15 gb|AAF01274.1|AF160500_1 (AF160500) repair endonuclease [Arabido... 83 1e-14 dbj|BAA28847.1| (AB009461) MUS38 [Neurospora crassa] 82 2e-14 gb|AAF81910.1|AF277377_1 (AF277377) 5' repair endonuclease [Arab... 80 7e-14 gb|AAF45938.1| (AE003430) mei-9 gene product [Drosophila melanog... 77 6e-13 sp|Q24087|MEI9_DROME MEI-9 PROTEIN (MEIOTIC-9 PROTEIN) >gi|21336... 75 2e-12 emb|CAB70217.1| (AL033535) Similarity to Yeast DNA repair protei... 75 3e-12 pir||T18568 hypothetical protein VF13D12L.2 - Caenorhabditis ele... 75 3e-12 dbj|BAB13422.1| (AB046816) KIAA1596 protein [Homo sapiens] 75 4e-12 dbj|BAA31233.1| (D89592) rhlE [Vibrio alginolyticus] 72 3e-11 pir||B72707 hypothetical protein APE1073 - Aeropyrum pernix (str... 72 3e-11 sp|P42305|DEAD_BACSU COLD-SHOCK DEAD-BOX PROTEIN A HOMOLOG (ATP-... 71 3e-11 gi|6325235 UV endonuclease; Rad1p [Saccharomyces cerevisiae] >gi... 70 7e-11 >pir||D75219 ATP-dependent RNA helicase, eif-4a family PAB0190 - Pyrococcus abyssi (strain Orsay) >gi|5457712|emb|CAB49203.1| (AJ248283) ATP-dependent RNA helicase, EIF-4A FAMILY [Pyrococcus abyssi] Length = 752 Score = 1465 bits (3751), Expect = 0.0 Identities = 752/752 (100%), Positives = 752/752 (100%) Query: 1 MNTMYLRKELLQPRLYQELIYAKCKERNCLIVLPTGLGKTIIAMMIADYRLNKYGGKVLM 60 MNTMYLRKELLQPRLYQELIYAKCKERNCLIVLPTGLGKTIIAMMIADYRLNKYGGKVLM Sbjct: 1 MNTMYLRKELLQPRLYQELIYAKCKERNCLIVLPTGLGKTIIAMMIADYRLNKYGGKVLM 60 Query: 61 LAPTKPLVLQHAETFRKFFNLPPEKIVALTGEVSPSERVKAWNRAKVIIATPQTVENDLL 120 LAPTKPLVLQHAETFRKFFNLPPEKIVALTGEVSPSERVKAWNRAKVIIATPQTVENDLL Sbjct: 61 LAPTKPLVLQHAETFRKFFNLPPEKIVALTGEVSPSERVKAWNRAKVIIATPQTVENDLL 120 Query: 121 TGKINLEDVVLVIFDEAHRAVGNYAYVYIAREYLNQAKNPHVIGLTASPGSSQEKILEVL 180 TGKINLEDVVLVIFDEAHRAVGNYAYVYIAREYLNQAKNPHVIGLTASPGSSQEKILEVL Sbjct: 121 TGKINLEDVVLVIFDEAHRAVGNYAYVYIAREYLNQAKNPHVIGLTASPGSSQEKILEVL 180 Query: 181 RNLGIEHIEYRSENSPDVKPYVQGIKFEWIKVELPGLYKEVRKLLRDMLRDSLKPLAEAG 240 RNLGIEHIEYRSENSPDVKPYVQGIKFEWIKVELPGLYKEVRKLLRDMLRDSLKPLAEAG Sbjct: 181 RNLGIEHIEYRSENSPDVKPYVQGIKFEWIKVELPGLYKEVRKLLRDMLRDSLKPLAEAG 240 Query: 241 LIESASADLPKKEILRAGQIINEETAKGNHDLRKLLLFHAMALKLHHAIELLETQGLSAL 300 LIESASADLPKKEILRAGQIINEETAKGNHDLRKLLLFHAMALKLHHAIELLETQGLSAL Sbjct: 241 LIESASADLPKKEILRAGQIINEETAKGNHDLRKLLLFHAMALKLHHAIELLETQGLSAL 300 Query: 301 RVYLKKLYEEAKTGSTRASKELFLDRRMKKALALLIQAKELGIDHPKMEVLKELVKEQLS 360 RVYLKKLYEEAKTGSTRASKELFLDRRMKKALALLIQAKELGIDHPKMEVLKELVKEQLS Sbjct: 301 RVYLKKLYEEAKTGSTRASKELFLDRRMKKALALLIQAKELGIDHPKMEVLKELVKEQLS 360 Query: 361 KKENSKIIVFTNYRETARKVVEELTKEGIKAKRFVGQATKENDRGMSQREQKLILDSFAR 420 KKENSKIIVFTNYRETARKVVEELTKEGIKAKRFVGQATKENDRGMSQREQKLILDSFAR Sbjct: 361 KKENSKIIVFTNYRETARKVVEELTKEGIKAKRFVGQATKENDRGMSQREQKLILDSFAR 420 Query: 421 GEFNVLVATSVGEEGLDVPEVDLVVFYEPVPSAIRSVQRRGRTGRQKPGRVVILIAQGTR 480 GEFNVLVATSVGEEGLDVPEVDLVVFYEPVPSAIRSVQRRGRTGRQKPGRVVILIAQGTR Sbjct: 421 GEFNVLVATSVGEEGLDVPEVDLVVFYEPVPSAIRSVQRRGRTGRQKPGRVVILIAQGTR 480 Query: 481 DEAYYWSSKHKERQMRETIRMVSQAIKREKQLSLESYVKKDTEKEMEREEKEERKGEREG 540 DEAYYWSSKHKERQMRETIRMVSQAIKREKQLSLESYVKKDTEKEMEREEKEERKGEREG Sbjct: 481 DEAYYWSSKHKERQMRETIRMVSQAIKREKQLSLESYVKKDTEKEMEREEKEERKGEREG 540 Query: 541 VKVVVDSRELRSEVVKRLKTLGVKIEVKTLDVGDYIISDEVAIERKSANDFIQSIIDGRL 600 VKVVVDSRELRSEVVKRLKTLGVKIEVKTLDVGDYIISDEVAIERKSANDFIQSIIDGRL Sbjct: 541 VKVVVDSRELRSEVVKRLKTLGVKIEVKTLDVGDYIISDEVAIERKSANDFIQSIIDGRL 600 Query: 601 FDQVKRLKDSYPRPVVIVEGQLYGIRNVHPNAIRGAIASIVIDFGVPIIFSSNPEETANY 660 FDQVKRLKDSYPRPVVIVEGQLYGIRNVHPNAIRGAIASIVIDFGVPIIFSSNPEETANY Sbjct: 601 FDQVKRLKDSYPRPVVIVEGQLYGIRNVHPNAIRGAIASIVIDFGVPIIFSSNPEETANY 660 Query: 661 IFFMARREQEERRREVRVRGEKKALTLAERQRLIVESLPHVSATLAKRLLKHFGSVERVF 720 IFFMARREQEERRREVRVRGEKKALTLAERQRLIVESLPHVSATLAKRLLKHFGSVERVF Sbjct: 661 IFFMARREQEERRREVRVRGEKKALTLAERQRLIVESLPHVSATLAKRLLKHFGSVERVF 720 Query: 721 TASVPELMKVEGIGEKIAREIRRVITSPYTED 752 TASVPELMKVEGIGEKIAREIRRVITSPYTED Sbjct: 721 TASVPELMKVEGIGEKIAREIRRVITSPYTED 752 >pir||D71203 probable ATP-dependent RNA helicase - Pyrococcus horikoshii >gi|3258336|dbj|BAA31019.1| (AP000007) 650aa long hypothetical ATP-dependent RNA helicase [Pyrococcus horikoshii] Length = 650 Score = 1146 bits (2931), Expect = 0.0 Identities = 566/655 (86%), Positives = 626/655 (95%), Gaps = 5/655 (0%) Query: 1 MNTMYLRKELLQPRLYQELIYAKCKERNCLIVLPTGLGKTIIAMMIADYRLNKYGGKVLM 60 MN MY+RK+LLQPRLYQELIYAKCKERNCLIVLPTGLGKTIIAMMIADYRL+KYGGKVLM Sbjct: 1 MNLMYIRKDLLQPRLYQELIYAKCKERNCLIVLPTGLGKTIIAMMIADYRLDKYGGKVLM 60 Query: 61 LAPTKPLVLQHAETFRKFFNLPPEKIVALTGEVSPSERVKAWNRAKVIIATPQTVENDLL 120 LAPTKPLVLQHAETFRKFF LPPEKIVALTGE+SP+ERV+AW RAKV+IATPQT+ENDLL Sbjct: 61 LAPTKPLVLQHAETFRKFFTLPPEKIVALTGEISPNERVRAWARAKVVIATPQTIENDLL 120 Query: 121 TGKINLEDVVLVIFDEAHRAVGNYAYVYIAREYLNQAKNPHVIGLTASPGSSQEKILEVL 180 G+I+LEDV L+IFDEAHRAVGNYAYVYIA+EYL QAKNPHVIGLTASPGS+ EKI+EVL Sbjct: 121 VGRISLEDVTLIIFDEAHRAVGNYAYVYIAKEYLKQAKNPHVIGLTASPGSTPEKIMEVL 180 Query: 181 RNLGIEHIEYRSENSPDVKPYVQGIKFEWIKVELPGLYKEVRKLLRDMLRDSLKPLAEAG 240 RNLGIEHIEYRSENSPDVKPYVQGIKFEW+KVELP LYKEVRKLLRDMLRDSLKPLAEAG Sbjct: 181 RNLGIEHIEYRSENSPDVKPYVQGIKFEWVKVELPELYKEVRKLLRDMLRDSLKPLAEAG 240 Query: 241 LIESASADLPKKEILRAGQIINEETAKGNHDLRKLLLFHAMALKLHHAIELLETQGLSAL 300 L++S SAD+PKKEILRAGQIINEE AKGNHDLRKLLLFHAMALKLHHAIELLETQGLSAL Sbjct: 241 LLDSTSADIPKKEILRAGQIINEEMAKGNHDLRKLLLFHAMALKLHHAIELLETQGLSAL 300 Query: 301 RVYLKKLYEEAKTGSTRASKELFLDRRMKKALALLIQAKELGIDHPKMEVLKELVKEQLS 360 RVYLK+LYEEAK GSTRASKELFLD+RMKKALALLIQAKELGIDHPKMEVLK L++EQL Sbjct: 301 RVYLKRLYEEAKAGSTRASKELFLDKRMKKALALLIQAKELGIDHPKMEVLKGLIREQLK 360 Query: 361 KKENSKIIVFTNYRETARKVVEELTKEGIKAKRFVGQATKENDRGMSQREQKLILDSFAR 420 +KENSKIIVFTNYRETA+KVVEEL K+GIKA+RFVGQA++ENDRGMSQ+EQKLILD+FAR Sbjct: 361 RKENSKIIVFTNYRETAKKVVEELMKDGIKARRFVGQASRENDRGMSQKEQKLILDAFAR 420 Query: 421 GEFNVLVATSVGEEGLDVPEVDLVVFYEPVPSAIRSVQRRGRTGRQKPGRVVILIAQGTR 480 EFNVLVATSVGEEGLDVPEVDLV+FYEPVPSAIRSVQRRGRTGRQKPGRVVIL+AQGTR Sbjct: 421 SEFNVLVATSVGEEGLDVPEVDLVIFYEPVPSAIRSVQRRGRTGRQKPGRVVILMAQGTR 480 Query: 481 DEAYYWSSKHKERQMRETIRMVSQAIKREKQLSLESYVKKDTEKEMEREEKEERKGEREG 540 DEAYYWSS+ KE+ MRETIRMVSQ +++E+QLSLESYVK++ +E++ E+K E G Sbjct: 481 DEAYYWSSRQKEKIMRETIRMVSQMVRKERQLSLESYVKREVNEEIKEEKK-----ETGG 535 Query: 541 VKVVVDSRELRSEVVKRLKTLGVKIEVKTLDVGDYIISDEVAIERKSANDFIQSIIDGRL 600 +KVV+DSRELRSEVVK+LKTLG+KIEV+TLDVGDYI+S++VAIERKSANDFIQSIIDGRL Sbjct: 536 IKVVIDSRELRSEVVKKLKTLGIKIEVRTLDVGDYIVSEDVAIERKSANDFIQSIIDGRL 595 Query: 601 FDQVKRLKDSYPRPVVIVEGQLYGIRNVHPNAIRGAIASIVIDFGVPIIFSSNPE 655 FDQVKRLK++YPRPV+I+EGQLYGIRNVHPNAIRGAIASIV+DFGVP+IFSS+ + Sbjct: 596 FDQVKRLKEAYPRPVIIIEGQLYGIRNVHPNAIRGAIASIVLDFGVPVIFSSSSD 650 >gi|11499053 ATP-dependent RNA helicase, putative [Archaeoglobus fulgidus] >gi|7428313|pir||A69432 ATP-dependent RNA helicase homolog - Archaeoglobus fulgidus >gi|2649107|gb|AAB89786.1| (AE001002) ATP-dependent RNA helicase, putative [Archaeoglobus fulgidus] Length = 741 Score = 699 bits (1784), Expect = 0.0 Identities = 370/749 (49%), Positives = 517/749 (68%), Gaps = 28/749 (3%) Query: 6 LRKELLQPRLYQELIYAKCKERNCLIVLPTGLGKTIIAMMIADYRLNKYGGKVLMLAPTK 65 +++ ++ R+YQ I A +N L+V+PTGLGKT IA ++ RL GKVL LAPTK Sbjct: 9 IKENTIERRMYQISIAATALTKNTLVVIPTGLGKTTIAALVIASRLLNEDGKVLFLAPTK 68 Query: 66 PLVLQHAETFRKFFNLPPEKIVALTGEVSPSERVKAWNRAKVIIATPQTVENDLLTGKIN 125 PLV QHA ++ + E+IV+L+GEV P +R + W +A+++++TPQ VENDLL G+I+ Sbjct: 69 PLVEQHARFLKRVLKV--EEIVSLSGEVPPEKRKELWEKARIVVSTPQVVENDLLAGRIS 126 Query: 126 LEDVVLVIFDEAHRAVGNYAYVYIAREYLNQAKNPHVIGLTASPGSSQEKILEVLRNLGI 185 LEDV+LV+FDEAHRAVGNYAYV+IA+EYL AK P ++ +TASPGS E+I+EV++NLGI Sbjct: 127 LEDVILVVFDEAHRAVGNYAYVFIAKEYLRTAKKPLILAMTASPGSDPERIMEVIQNLGI 186 Query: 186 EHIEYRSENSPDVKPYVQGIKFEWIKVELPGLYKEVRKLLRDMLRDSLKPLAEAGLIESA 245 E IE R+E DV PYV + EWIKV++P KEV++ L++ ++ K L E + Sbjct: 187 EAIEVRTEWDSDVAPYVGKKRIEWIKVDIPEEMKEVKERLKECIKIRFKRLRELWI--EV 244 Query: 246 SADLPKKEILRAGQIINEETAKG-NHDLRKLLLFHAMALKLHHAIELLETQGLSALRVYL 304 + K+++L + + E A + ++ + L A +KL HA+EL+ETQG+ A++ YL Sbjct: 245 PENSSKRDLLALQEALQAEAASSQSSEIFEALSILAEIMKLQHAVELIETQGVKAVKSYL 304 Query: 305 KKLYEEAKT-GSTRASKELFLDRRMKKALALLIQAKELGIDHPKMEVLKELVKEQLSKKE 363 +KL EA + G ++A+K + D KKA+ L + K ++HPK+E LKE++KEQ K Sbjct: 305 RKLVREATSKGGSKAAKSIVGDPIFKKAVIALSKCK---VEHPKLEKLKEILKEQFEKNP 361 Query: 364 NSKIIVFTNYRETARKVVEELTKEGIKAKRFVGQATKENDRGMSQREQKLILDSFARGEF 423 +S++IVFTNYR++A +V EL+ AK FVGQA+++ND+GM Q+EQ +D F RG + Sbjct: 362 DSRVIVFTNYRDSAEMLVNELSPLFPVAK-FVGQASRDNDKGMRQKEQIETIDKFRRGVY 420 Query: 424 NVLVATSVGEEGLDVPEVDLVVFYEPVPSAIRSVQRRGRTGRQKPGRVVILIAQGTRDEA 483 VLVATSVGEEGLD+P DLVVFYE VPS IR++QR+GRTGR + GR+V+L+ +GTRDEA Sbjct: 421 KVLVATSVGEEGLDIPSTDLVVFYEAVPSEIRAIQRKGRTGRGREGRIVVLVTKGTRDEA 480 Query: 484 YYWSSKHKERQMRETIRMVSQAIKREKQLSLESYVKKDTEKEMEREEKEERKGEREGVKV 543 YY+SS KER+M + I + + I R KQ S+ YV E G+KV Sbjct: 481 YYYSSMKKERKMYDKILEIKRIIDR-KQRSIGDYVLP----------------EETGIKV 523 Query: 544 VVDSRELRSEVVKRLKTLGVKIEVKTLDVGDYIISDEVAIERKSANDFIQSIID-GRLFD 602 +VDSRELRSEVVK L+ +G KIE++ L+V DY++SD VA+ERK+ DF+ SII RLF Sbjct: 524 IVDSRELRSEVVKHLREIGAKIEIRNLEVADYVVSDRVAVERKTVEDFLNSIIQKERLFS 583 Query: 603 QVKRLKDSYPRPVVIVEGQLYGIRNVHPNAIRGAIASIVIDFGVPIIFSSNPEETANYIF 662 QV RLK +Y RPV+I+EG+ + VHPNA+RGAIAS++IDFG+P++ SSN ETA IF Sbjct: 584 QVARLKSAYSRPVIIIEGENFYRGGVHPNAVRGAIASLIIDFGIPVLRSSNARETAELIF 643 Query: 663 FMARREQEERRREVRVRGEKKALTLAERQRLIVESLPHVSATLAKRLLKHFGSVERVFTA 722 MARREQEER+R V K TL + Q IV ++ +V +A+ LL +F ++E + TA Sbjct: 644 AMARREQEERKRGVVEHTAKTKRTLKDEQEYIVSAISNVGNVIARNLLDYFQTIENIATA 703 Query: 723 SVPELMKVEGIGEKIAREIRRVITSPYTE 751 EL KV +G+KIA+ IRRV+T+PY+E Sbjct: 704 DEEELAKVPKVGKKIAKRIRRVMTTPYSE 732 >pir||E69055 ATP-dependent RNA helicase, eIF-4A family - Methanobacterium thermoautotrophicum (strain Delta H) >gi|2622527|gb|AAB85892.1| (AE000903) ATP-dependent RNA helicase, eIF-4A family [Methanobacterium thermoautotrophicum] Length = 738 Score = 611 bits (1558), Expect = e-173 Identities = 327/749 (43%), Positives = 493/749 (65%), Gaps = 37/749 (4%) Query: 6 LRKELLQPRLYQELIYAKC-KERNCLIVLPTGLGKTIIAMMIADYRLNKY-GGKVLMLAP 63 ++ E ++ R YQ+L+ A ++ N +IV PT LGKT++A+++A RL KY G KVL+L+P Sbjct: 10 IKPEKIEARTYQQLLAADVIRKGNSMIVAPTALGKTVVAVLVAAERLRKYRGSKVLILSP 69 Query: 64 TKPLVLQHAETFRKFFNLPPEKIVALTGEVSPSERVKAWNRAKVIIATPQTVENDLLTGK 123 +KPL +QH E+FR+F +LTG + P ER + W ++++I ATPQTVE+D+L G+ Sbjct: 70 SKPLAIQHEESFREFMLAT---CTSLTGSIKPEERKERWIKSQIISATPQTVESDILAGR 126 Query: 124 INLEDVVLVIFDEAHRAVGNYAYVYIAREYLNQAKNPHVIGLTASPGSSQEKILEVLRNL 183 +L DV L++FDE HRAVG+Y+YV++A Y+ A++P ++GLTASPG+ ++KI V NL Sbjct: 127 YDLRDVSLIVFDECHRAVGSYSYVFLASNYIQNARHPLILGLTASPGADEDKIKTVCENL 186 Query: 184 GIEHIEYRSENSPDVKPYVQGIKFEWIKVELPGLYKEVRKLLRDMLRDSLKPLAEAGLIE 243 + + ++E PDV+PY++ IK EW+KV + +++R+LLR +L++ LK L G+I+ Sbjct: 187 FMNEVVVKTEGDPDVRPYLKPIKIEWVKVRMTPELEDIRELLRKVLKNRLKMLKNLGVID 246 Query: 244 SASADLPKKEILRAGQIINEETAKGNHDLR---KLLLFHAMALKLHHAIELLETQGLSAL 300 + S + KK++L+A + A+ R + + A + + HA+ELLETQG+ L Sbjct: 247 TIS--VGKKDLLKARGRVQNRIARSTSPPRACYRAISLLASCINVEHALELLETQGIRPL 304 Query: 301 RVYLKKLYEEAKTGSTRASKELFLDRRMKKALALLIQAKELGIDHPKMEVLKELVKEQLS 360 YL +L E+ T+A+K L D +A+ L +A G++HPK++ L E++K +L Sbjct: 305 HQYLLRLKEK----KTKAAKGLLADPDFTRAMHLTRRAMMSGVEHPKLDRLMEILKREL- 359 Query: 361 KKENSKIIVFTNYRETARKVVEELTKEGIKAKRFVGQATKENDRGMSQREQKLILDSFAR 420 K + ++IIVFT +R+T ++ + +EGI A +F GQ ++ ++G++Q++Q+ I+ SF Sbjct: 360 KGDEARIIVFTQFRDTLEEIYQRCKREGINAVKFYGQNSRSGEKGLTQKQQRDIIKSFRM 419 Query: 421 GEFNVLVATSVGEEGLDVPEVDLVVFYEPVPSAIRSVQRRGRTGRQKPGRVVILIAQGTR 480 G +VL++TSV EEG+D+P VDLVV YEPVPS IR +QRRGRTGR++ GR+V+LI + TR Sbjct: 420 GNHDVLLSTSVAEEGIDIPSVDLVVMYEPVPSEIRMIQRRGRTGRKRKGRMVVLITEKTR 479 Query: 481 DEAYYWSSKHKERQMRETIRMVSQAIKREKQLSLESYVKKDTEKEMEREEKEERKGEREG 540 DEAYY+SS KER M+E +R S V + ME EG Sbjct: 480 DEAYYYSSIRKERSMKENLRGGS--------------VNVEVNPIME--------PSGEG 517 Query: 541 VKVVVDSRELRSEVVKRLKTLGVKIEVKTLDVGDYIISDEVAIERKSANDFIQSIIDGRL 600 + DSRE+ S V++ LK +GV E+K L VGDY IS++ IERK+ DFI SIID RL Sbjct: 518 PFIYADSREVNSRVLRELKKIGVDFELKPLAVGDYQISEDTIIERKTTQDFIGSIIDKRL 577 Query: 601 FDQVKRLKDSYPRPVVIVEGQLYGIRNVHPNAIRGAIASIVIDFGVPIIFSSNPEETANY 660 + Q + + ++ RPV+I+EG ++P+A+RGA+A++ +DFG+P+I + + E+TA Sbjct: 578 YKQAREMVKNFKRPVMIIEGDDLYSGFINPDAVRGALAAVAVDFGIPVIPTRSAEDTAAM 637 Query: 661 IFFMARREQEERRREVRVRGEKKALTLAERQRLIVESLPHVSATLAKRLLKHFGSVERVF 720 I +A REQ E R ++RVR +KK LTL E+Q IVESLP++ + A+RLL+ FGSVE V Sbjct: 638 IRRIAIREQREGRPDMRVRTDKKPLTLREKQLFIVESLPNIGSKYAERLLEAFGSVEGVM 697 Query: 721 TASVPELMKVEGIGEKIAREIRRVITSPY 749 AS EL VEGIG K A EIRRVI + + Sbjct: 698 NASEKELRSVEGIGAKRASEIRRVIEAEF 726 >pir||H64487 eIF-4A family probable ATP-dependent RNA helicase homolog - Methanococcus jannaschii Length = 784 Score = 608 bits (1552), Expect = e-173 Identities = 338/800 (42%), Positives = 519/800 (64%), Gaps = 76/800 (9%) Query: 3 TMYLRKELLQP-----RLYQELIYAKCKERNCLIVLPTGLGKTIIAMMIADYRLNKYGGK 57 TM++ L++P RLYQ++I A ++ L VL TGLGKT IA+++ L K GK Sbjct: 6 TMFIEHPLIKPKTLEARLYQQIIAANALKKKTLCVLSTGLGKTAIAILVIAGILTKKDGK 65 Query: 58 VLMLAPTKPLVLQHAETFRKFFNLPPEKIVALTGEVSPSERVKAWNRAKVIIATPQTVEN 117 VL+LAP++PLV QH ++ N+ +KI+ALTG++ P +R + + + K+ IATPQ +EN Sbjct: 66 VLILAPSRPLVEQHYNRLKQVLNIDEDKIIALTGKIQPKKRAELYKKGKIFIATPQVIEN 125 Query: 118 DLLTGKINLEDVVLVIFDEAHRAVGNYAYVYIAREYLNQAKNPHVIGLTASPGSSQEKIL 177 D++ G+IN+++ +L+I DEAH G++AY ++A+++ ++ H++GLTASPGS +K++ Sbjct: 126 DIIAGRINVDEFILLIADEAHHTTGDHAYAFVAKKFKDKC---HILGLTASPGSDIDKVM 182 Query: 178 EVLRNLGIEHIEYRSENSPDVKPYVQGIKFEWIKVELPGLYKEVRKLLRDMLRDSLKPLA 237 E+ NLGIEH+E R+E+ DVKPY+ +K I+++LP +K KL+ + L++ LK L Sbjct: 183 EICENLGIEHVEVRTEDDEDVKPYIAKVKLIPIRIDLPNEFKRALKLINEALKERLKILK 242 Query: 238 EAGLIESASADLPKKEILRAGQIINEETAKGNHDLRKLLLFHAMALKLHHAIELLETQGL 297 +AG+I S AD+ K E++ + + ++L K+ + ALKL HA ELLE+QG Sbjct: 243 DAGVINSI-ADVTKTELIELNNKLFSYDEEVKYELIKVC---SEALKLMHAKELLESQGK 298 Query: 298 SALRVYLKKLYEEAKTGSTRASKELFLDRRMKKALALLIQAKELGIDHPKMEVLKELVKE 357 S Y+ KL + T+++K + D ++++A+ LL+++ ++HPK+ + ++VK Sbjct: 299 SVFLNYINKLSMQ----RTKSAKSIVNDEKVREAVNLLMKS---DVEHPKLGKVVDMVKN 351 Query: 358 QLSKKENSKIIVFTNYRETARKVVEELTKEGIKAKRFVGQATKENDRGMSQREQKLILDS 417 L K ++ +II+F YR+T K+V LT+ GIKA RF+GQA KE +GMSQ+EQ ++ Sbjct: 352 ILEKNKDERIIIFAQYRDTVEKIVNLLTQNGIKAIRFIGQANKEG-KGMSQKEQIEAIER 410 Query: 418 FARGEFNVLVATSVGEEGLDVPEVDLVVFYEPVPSAIRSVQRRGRTGRQKPGRVVILIAQ 477 F + E +VLV+TSV EEG+D+P V+ ++FYEPVPS IR +QRRGR R + G+V +LIA+ Sbjct: 411 FKK-EGSVLVSTSVSEEGIDIPSVNYIIFYEPVPSEIRFIQRRGRAMRGEGGKVYVLIAK 469 Query: 478 GTRDEAYYWSSKHKERQM-----------------------RETIRMVSQAIKREKQLSL 514 GT DEAYY S+ +KER+M +E I+ ++ IK EK++ Sbjct: 470 GTADEAYYRSALYKEREMKRLLKNMCYLLNKRLQKKFEEKSKEEIKEETEEIK-EKEIES 528 Query: 515 ESYVKKDTEKEMER--------------EEKEERKGE-----------REGVKVVVDSRE 549 ++ VK++T++E E+ E KE K E ++ +K++VD RE Sbjct: 529 KTAVKEETKEEEEKTKKPVTILDFIKQIEVKERSKSEEDKIKQEIKIPKKPIKIIVDVRE 588 Query: 550 LRSEVVKRLKTLGVKIEVKTLDVGDYIISDEVAIERKSANDFIQSIIDGRLFDQVKRLKD 609 + K L IE+KTL+VGDY++SD V +ERK+A DF+ SIID RLF Q+K LK Sbjct: 589 --KNMAKLLHNY-ANIELKTLEVGDYVLSDRVVVERKTAEDFVNSIIDKRLFSQLKNLK- 644 Query: 610 SYPRPVVIVEGQLYGIRNVHPNAIRGAIASIVIDFGVPIIFSSNPEETANYIFFMARREQ 669 +P++IVEG+ + +H NA++GAI SI++DFG+PIIF+ N EETA+ + +A +EQ Sbjct: 645 KVEKPLLIVEGENFS--RLHENALKGAILSIILDFGIPIIFTKNAEETADLLIKIAEKEQ 702 Query: 670 EERRREVRVRGEKKALTLAERQRLIVESLPHVSATLAKRLLKHFGSVERVFTASVPELMK 729 + +R V VR K A++L E+Q+ IVESLP V LA+RLLKHF +VE VFTA ELMK Sbjct: 703 IKEKRTVMVRYGKTAMSLKEQQKFIVESLPDVGGALAERLLKHFKTVENVFTAKEEELMK 762 Query: 730 VEGIGEKIAREIRRVITSPY 749 VEG+G++ A++IR V+T+ Y Sbjct: 763 VEGVGKERAKKIREVLTAEY 782 >sp|Q58900|YF05_METJA PUTATIVE ATP-DEPENDENT RNA HELICASE MJ1505 >gi|2826423|gb|AAB99518.1| (U67591) ATP dependent RNA helicase, putative [Methanococcus jannaschii] Length = 778 Score = 607 bits (1549), Expect = e-172 Identities = 335/792 (42%), Positives = 516/792 (64%), Gaps = 71/792 (8%) Query: 6 LRKELLQPRLYQELIYAKCKERNCLIVLPTGLGKTIIAMMIADYRLNKYGGKVLMLAPTK 65 ++ + L+ RLYQ++I A ++ L VL TGLGKT IA+++ L K GKVL+LAP++ Sbjct: 8 IKPKTLEARLYQQIIAANALKKKTLCVLSTGLGKTAIAILVIAGILTKKDGKVLILAPSR 67 Query: 66 PLVLQHAETFRKFFNLPPEKIVALTGEVSPSERVKAWNRAKVIIATPQTVENDLLTGKIN 125 PLV QH ++ N+ +KI+ALTG++ P +R + + + K+ IATPQ +END++ G+IN Sbjct: 68 PLVEQHYNRLKQVLNIDEDKIIALTGKIQPKKRAELYKKGKIFIATPQVIENDIIAGRIN 127 Query: 126 LEDVVLVIFDEAHRAVGNYAYVYIAREYLNQAKNPHVIGLTASPGSSQEKILEVLRNLGI 185 +++ +L+I DEAH G++AY ++A+++ ++ H++GLTASPGS +K++E+ NLGI Sbjct: 128 VDEFILLIADEAHHTTGDHAYAFVAKKFKDKC---HILGLTASPGSDIDKVMEICENLGI 184 Query: 186 EHIEYRSENSPDVKPYVQGIKFEWIKVELPGLYKEVRKLLRDMLRDSLKPLAEAGLIESA 245 EH+E R+E+ DVKPY+ +K I+++LP +K KL+ + L++ LK L +AG+I S Sbjct: 185 EHVEVRTEDDEDVKPYIAKVKLIPIRIDLPNEFKRALKLINEALKERLKILKDAGVINSI 244 Query: 246 SADLPKKEILRAGQIINEETAKGNHDLRKLLLFHAMALKLHHAIELLETQGLSALRVYLK 305 AD+ K E++ + + ++L K+ + ALKL HA ELLE+QG S Y+ Sbjct: 245 -ADVTKTELIELNNKLFSYDEEVKYELIKVC---SEALKLMHAKELLESQGKSVFLNYIN 300 Query: 306 KLYEEAKTGSTRASKELFLDRRMKKALALLIQAKELGIDHPKMEVLKELVKEQLSKKENS 365 KL + T+++K + D ++++A+ LL+++ ++HPK+ + ++VK L K ++ Sbjct: 301 KLSMQ----RTKSAKSIVNDEKVREAVNLLMKS---DVEHPKLGKVVDMVKNILEKNKDE 353 Query: 366 KIIVFTNYRETARKVVEELTKEGIKAKRFVGQATKENDRGMSQREQKLILDSFARGEFNV 425 +II+F YR+T K+V LT+ GIKA RF+GQA KE +GMSQ+EQ ++ F + E +V Sbjct: 354 RIIIFAQYRDTVEKIVNLLTQNGIKAIRFIGQANKEG-KGMSQKEQIEAIERFKK-EGSV 411 Query: 426 LVATSVGEEGLDVPEVDLVVFYEPVPSAIRSVQRRGRTGRQKPGRVVILIAQGTRDEAYY 485 LV+TSV EEG+D+P V+ ++FYEPVPS IR +QRRGR R + G+V +LIA+GT DEAYY Sbjct: 412 LVSTSVSEEGIDIPSVNYIIFYEPVPSEIRFIQRRGRAMRGEGGKVYVLIAKGTADEAYY 471 Query: 486 WSSKHKERQM-----------------------RETIRMVSQAIKREKQLSLESYVKKDT 522 S+ +KER+M +E I+ ++ IK EK++ ++ VK++T Sbjct: 472 RSALYKEREMKRLLKNMCYLLNKRLQKKFEEKSKEEIKEETEEIK-EKEIESKTAVKEET 530 Query: 523 EKEMER--------------EEKEERKGE-----------REGVKVVVDSRELRSEVVKR 557 ++E E+ E KE K E ++ +K++VD RE + K Sbjct: 531 KEEEEKTKKPVTILDFIKQIEVKERSKSEEDKIKQEIKIPKKPIKIIVDVRE--KNMAKL 588 Query: 558 LKTLGVKIEVKTLDVGDYIISDEVAIERKSANDFIQSIIDGRLFDQVKRLKDSYPRPVVI 617 L IE+KTL+VGDY++SD V +ERK+A DF+ SIID RLF Q+K LK +P++I Sbjct: 589 LHNY-ANIELKTLEVGDYVLSDRVVVERKTAEDFVNSIIDKRLFSQLKNLK-KVEKPLLI 646 Query: 618 VEGQLYGIRNVHPNAIRGAIASIVIDFGVPIIFSSNPEETANYIFFMARREQEERRREVR 677 VEG+ + +H NA++GAI SI++DFG+PIIF+ N EETA+ + +A +EQ + +R V Sbjct: 647 VEGENFS--RLHENALKGAILSIILDFGIPIIFTKNAEETADLLIKIAEKEQIKEKRTVM 704 Query: 678 VRGEKKALTLAERQRLIVESLPHVSATLAKRLLKHFGSVERVFTASVPELMKVEGIGEKI 737 VR K A++L E+Q+ IVESLP V LA+RLLKHF +VE VFTA ELMKVEG+G++ Sbjct: 705 VRYGKTAMSLKEQQKFIVESLPDVGGALAERLLKHFKTVENVFTAKEEELMKVEGVGKER 764 Query: 738 AREIRRVITSPY 749 A++IR V+T+ Y Sbjct: 765 AKKIREVLTAEY 776 >gb|AAG20456.1| (AE005118) ATP-dependent RNA helicase homolog eIF-4A; Eif4a [Halobacterium sp. NRC-1] Length = 784 Score = 548 bits (1397), Expect = e-155 Identities = 312/773 (40%), Positives = 467/773 (60%), Gaps = 41/773 (5%) Query: 10 LLQPRLYQELIYAKCKERNCLIVLPTGLGKTIIAMMIADYRL-NKYGGKVLMLAPTKPLV 68 +++ R YQ + A ++ + L+ LPTGLGKT +++++ YRL + GG L+LAPTKPLV Sbjct: 17 VIEARQYQLQLAAAARQGHTLVCLPTGLGKTTVSLLVTAYRLADDAGGTALLLAPTKPLV 76 Query: 69 LQHAETFRKFFNLPPEKIVALTGEVSPSERVKAWNRAKVIIATPQTVENDLLTGKINLED 128 QHA +R+ +P + +V TGE P +R AW A+V++ATPQ VENDL+ G+I+++D Sbjct: 77 EQHAGFYREALAIPDDDVVVFTGETRPDDRRAAWTDARVVVATPQVVENDLVGGRIDMDD 136 Query: 129 VVLVIFDEAHRAVGNYAYVYIAREYLNQAKNPHVIGLTASPGSSQEKILEVLRNLGIEHI 188 VV FDE HRA G+YAY Y+A Y A P V ++ASPG ++ +I V NLG+ ++ Sbjct: 137 VVHCTFDECHRATGDYAYTYVAERYHADAAAPLVTAMSASPGGTEAEIRTVCENLGVGNV 196 Query: 189 EYRSENSPDVKPYVQGIKFEWIKVELPGLYKEVRKLLRDMLRDSLKPLAEAGLIESASAD 248 E +E+ DV + +W +V LP EVR + D++ D L L E G+ +++S D Sbjct: 197 EVMTEDDADVGEHTHDTDVQWERVTLPEEILEVRDAINDVIEDRLAKLREIGVTKASSPD 256 Query: 249 LPKKEI----LRAGQIINEETAKGNHDLRKLLLFHAMALKLHHAIELLETQGLSALRVYL 304 + +K++ R Q+I+++ + G + HA +KL A+EL+ETQ + ++R Y Sbjct: 257 ISQKDLNEIRARLQQLIDDDDSDGYQGMS----VHAEVMKLKRAVELVETQSVESVRRYF 312 Query: 305 KKLYEEAKT-GSTRASKELFLDRRMKKALALLIQAKELGIDHPKMEVLKELVKEQLSKKE 363 ++ A T G+++AS+ L + +K+A+ A+E HPK + L+ E L ++ Sbjct: 313 ERQRNAANTAGASKASQRLVSEPAVKRAMR---TAREFDGLHPKFRQARMLLAETLGIED 369 Query: 364 NSKIIVFTNYRETARKVVEELTKEGIKAKRFVGQATKENDRGMSQREQKLILDSFARGEF 423 ++IVFT R+TA + L E +RFVGQ + GM+Q EQ+ L F G+F Sbjct: 370 GDRVIVFTESRDTAEALTAFL-GEHFDTRRFVGQGDADGSDGMTQTEQRETLAEFRNGDF 428 Query: 424 NVLVATSVGEEGLDVPEVDLVVFYEPVPSAIRSVQRRGRTGRQKPGRVVILIAQGTRDEA 483 VLV+TSV EEGLDVPEVDLV+F+EPVP+AIRSVQR+GRTGRQ GRVV+L+A+ TRDEA Sbjct: 429 EVLVSTSVAEEGLDVPEVDLVLFFEPVPTAIRSVQRKGRTGRQTAGRVVVLLAEDTRDEA 488 Query: 484 YYWSSKHKERQMRETIR-MVSQAIKREKQL-------SLESYVKKDT----------EKE 525 Y+W S+ +E++M E ++ + +A + E +L +L+ + + E Sbjct: 489 YFWISRRREQEMTEELQSLKGRADELETELGGDGAQQALDEFGDAEAAGEEPAAPAPEDV 548 Query: 526 MEREEKE----ERKGEREGVKVVVDSRELRSEVVKRL-KTLGVKIEVKTLDVGDYIISDE 580 + E+ E G E V+VVVD REL S + + L K GV+ ++TL VGDY++SD Sbjct: 549 SDGEDTEGVAARVDGAGEAVEVVVDQRELDSTIARELSKRDGVETRLETLAVGDYVVSDR 608 Query: 581 VAIERKSANDFIQSII--DGRLFDQVKRLKDSYPRPVVIVE--GQLYGIRNVHPNAIRGA 636 VA+ERKS +DF+ +++ + +F+Q K L Y RPV++VE G LY RNVHPNA+R A Sbjct: 609 VAVERKSHSDFMDTLLGSERSIFEQAKELARQYTRPVLVVEGDGDLYAERNVHPNAVRSA 668 Query: 637 IASIVIDFGVPIIFSSNPEETANYIFFMARREQEERRREVRVRGEKKALTLAERQRLIVE 696 +AS+ +D+G+ ++ ++ +T I +A REQ R V GEK A T E+Q +V Sbjct: 669 MASLAVDWGLSVMHTNGEGDTTEMIETIAEREQTTNDRAVSAHGEKAAKTQGEQQEYVVS 728 Query: 697 SLPHVSATLAKRLLKHFGSVERVFTASVPELMKVEGIGEKIAREIRRVITSPY 749 S+ V A+ LL FGSVE V TAS EL +G+G A IR V+ + Y Sbjct: 729 SITDVGPVTARSLLDTFGSVEAVMTASEDELTAADGVGAVTAERIRGVVGTEY 781 >emb|CAC12619.1| (AL445067) RNA helicase (RIG-I) related protein [Thermoplasma acidophilum] Length = 508 Score = 342 bits (869), Expect = 6e-93 Identities = 210/521 (40%), Positives = 311/521 (59%), Gaps = 25/521 (4%) Query: 10 LLQPRLYQELIYAKCKERNCLIVLPTGLGKTIIAMMIADYRLNKYGGKV--LMLAPTKPL 67 ++QPR YQ ++ +N LIV+PTGLGKTIIA M + YG K LM+APTKPL Sbjct: 2 IIQPREYQLNVFKNSIGQNTLIVMPTGLGKTIIAAMFIE---KFYGEKKRSLMVAPTKPL 58 Query: 68 VLQHAETFRKFFNLPPEKIVALTGEVSPSERVKAWNRAKVIIATPQTVENDLLTGKINLE 127 VLQHA T + +I TGE+ ER W K+ ++TPQ V ND+ +G +++ Sbjct: 59 VLQHARTIADSTGISENEIGVFTGEIDAEERELIWVTKKIFVSTPQVVFNDMRSGILDIT 118 Query: 128 DVVLVIFDEAHRAVGNYAYVYIAREYLNQAKNPHVIGLTASPGSSQEKILEVLRNLGIEH 187 L+IFDEAHRAVGNYAYV IA+EYL K +IGLTASPGSS+EKI E++ NLGI Sbjct: 119 KFDLIIFDEAHRAVGNYAYVDIAQEYLKYKKKL-IIGLTASPGSSREKIDEIMANLGISK 177 Query: 188 IEYRSENSPDVKPYVQGIKFEWIKVELPGLYKEVRKLLRDMLRDSLKPLAEAGLIESASA 247 + ++E DV+ YV+ I + IK+ P KE+ ++ ++ L+P+ + S Sbjct: 178 VIAKTEMDEDVRKYVKTIDVKLIKIREPDGTKEIVNMIDAVMSKLLEPVKSSNF----SI 233 Query: 248 DLPKKEILRAGQ-IINEETAKGNHDLRKLLLFHAMALKLHHAIELLETQGLSALRVYLKK 306 +K+++ Q +IN +AK + L +L+ A++L + E +ETQG+ YL++ Sbjct: 234 GRSRKDLVATMQKVIN--SAKEDRSLFQLVRRITAAIRLDYLKEYIETQGIDVALHYLEE 291 Query: 307 LYEEAKTGSTRASKELF-LDRRMKKALALLIQAKELGIDHPKMEVLKELVKEQLSKKENS 365 + + G RA L LD L++ A G +PKME +++ + N+ Sbjct: 292 MEKSQDPGIRRAISMLSSLDEFATLRTKLMLAAD--GYTNPKMEKTLSIMESNVHG--NA 347 Query: 366 KIIVFTNYRETARKVVEELTKEG--IKAKRFVGQATKENDRGMSQREQKLILDSFARGEF 423 + IVFT+YR T+ +++ + K G +K RF+GQA + +D G+SQ +QK I++ F + Sbjct: 348 RAIVFTHYRITSDLLMDYIQKNGTSLKPVRFIGQADRGSDEGLSQDQQKKIIEDFKNNVY 407 Query: 424 NVLVATSVGEEGLDVPEVDLVVFYEPVPSAIRSVQRRGRTGRQKPGRVVILIAQGTRDEA 483 NVL+ATS+ EEGLD+P+ D V+FYE VPS IR +QR+GRTGR + G+V IL+ + +RD A Sbjct: 408 NVLIATSIAEEGLDIPDTDFVIFYEAVPSEIRYIQRKGRTGRSRNGQVYILVFENSRDMA 467 Query: 484 YYWSSKHKERQMRETIRMVSQAIKREKQLSLESYVKKDTEK 524 YY+SS K +M +TI + R++ S E K D +K Sbjct: 468 YYYSSIRKVSRMTQTIEDL-----RQESGSDEKEEKSDVQK 503 >gb|AAC62691.1| (AF083071) ATP-dependent RNA helicase [Cenarchaeum symbiosum] Length = 503 Score = 303 bits (767), Expect = 6e-81 Identities = 186/487 (38%), Positives = 276/487 (56%), Gaps = 27/487 (5%) Query: 5 YLRKELLQPRLYQELIYAKCKERNCLIVLPTGLGKTIIAMMIADYRLNKYGGKVLMLAPT 64 Y+ ++ R YQ + + NC++VLPTGLGKT +A+ + + L++ G L LAPT Sbjct: 10 YVEPGAVERRDYQVGLAEQAIRENCIVVLPTGLGKTAVALQVISHYLDE-GRGALFLAPT 68 Query: 65 KPLVLQHAETFRKFFNLPPEKIVALTGEVSPSERVKAWNRAKVIIATPQTVENDLLTGKI 124 + LV QH + + + I +TGE + R KAW VI ATP+ ND+ G + Sbjct: 69 RVLVNQHRQFLGRALTI--SDITLVTGEDTVPRRKKAWG-GSVICATPEITRNDIARGMV 125 Query: 125 NLEDVVLVIFDEAHRAVGNYAYVYIAREYLNQAKNPHVIGLTASPGSSQEKILEVLRNLG 184 LE LV+FDEAHRAVG+YAY IAR +N +IG+TA+ S +EK E++ L Sbjct: 126 PLEQFGLVVFDEAHRAVGDYAYSAIARAV---GENSRMIGMTATLPSEREKADEIMGTLL 182 Query: 185 IEHIEYRSENSPDVKPYVQGIKFEWIKVELPGLYKEVRKLLRDMLRDSLKPLAEAGLIES 244 + I R+E+ PDVKPYVQ + EWIKVELP KE++KLL+ L + L G Sbjct: 183 SKSIAQRTEDDPDVKPYVQETETEWIKVELPPEMKEIQKLLKMALDERYAALKRCGY--- 239 Query: 245 ASADLPKKEILRAGQIINEETAKGNHDLRKLLLFHAMALKLHHAIELLETQGLSALRVYL 304 DL L A + GN K L A+++ +A+ + E G++ + Sbjct: 240 ---DLGSNRSLSALLRLRMVVLSGNRRAAKPLF---TAIRITYALNIFEAHGVTPFLKFC 293 Query: 305 KKLYEEAKTGSTRASKELFLDRRMKKALALLIQAKELGIDHPKMEVLKELVKEQLSKKEN 364 ++ ++ G +E DR A+A A+ G++HPK+ L+E V+ Sbjct: 294 ERTVKKKGAGVAELFEE---DRNFTGAMARAKAAQAAGMEHPKIPKLEEAVRGA-----K 345 Query: 365 SKIIVFTNYRETARKVVEELTKEGIKAKRFVGQATKENDRGMSQREQKLILDSFARGEFN 424 K +VFT+YR++ + +L GI + +G+A ++G+ Q++Q + F G ++ Sbjct: 346 GKALVFTSYRDSVDLIHSKLQAAGINSGILIGKA---GEKGLKQKKQVETVAKFRDGGYD 402 Query: 425 VLVATSVGEEGLDVPEVDLVVFYEPVPSAIRSVQRRGRTGRQKPGRVVILIAQGTRDEAY 484 VLV+T VGEEGLD+ EV+LVVFY+ VPS+IR VQRRGRTGR+ G++V+L+A+GT DEAY Sbjct: 403 VLVSTRVGEEGLDISEVNLVVFYDNVPSSIRYVQRRGRTGRKDAGKLVVLMAKGTIDEAY 462 Query: 485 YWSSKHK 491 YW + K Sbjct: 463 YWIGRRK 469 >pir||T31323 ATP-dependent RNA helicase, eIF-4A family - Cenarchaeum symbiosum >gi|3599409|gb|AAC62714.1| (AF083072) ATP-dependent RNA helicase [Cenarchaeum symbiosum] Length = 502 Score = 294 bits (745), Expect = 2e-78 Identities = 182/487 (37%), Positives = 272/487 (55%), Gaps = 27/487 (5%) Query: 5 YLRKELLQPRLYQELIYAKCKERNCLIVLPTGLGKTIIAMMIADYRLNKYGGKVLMLAPT 64 Y+ ++ R YQ + + NC++VLPTGLGKT +A+ + + L++ G L LAPT Sbjct: 10 YIEPGAVERRDYQVGLAEQAIRENCIVVLPTGLGKTAVALQVIAHYLDE-GRGALFLAPT 68 Query: 65 KPLVLQHAETFRKFFNLPPEKIVALTGEVSPSERVKAWNRAKVIIATPQTVENDLLTGKI 124 + LV QH + + + I +TGE + R KAW VI ATP+ ND+ G + Sbjct: 69 RVLVNQHRQFLGRALTI--SDITLVTGEDTIPRRKKAWG-GSVICATPEIARNDIERGLV 125 Query: 125 NLEDVVLVIFDEAHRAVGNYAYVYIAREYLNQAKNPHVIGLTASPGSSQEKILEVLRNLG 184 LE LVIFDEAHRAVG+YAY IAR N ++G+TA+ S +EK E++ L Sbjct: 126 PLEQFGLVIFDEAHRAVGDYAYSSIARAV---GDNSRMVGMTATLPSEREKADEIMGTLL 182 Query: 185 IEHIEYRSENSPDVKPYVQGIKFEWIKVELPGLYKEVRKLLRDMLRDSLKPLAEAGLIES 244 I R+E+ PDVKPYVQ EWIKV+LP KE+++LL+ L + L G Sbjct: 183 SRSIAQRTEDDPDVKPYVQETATEWIKVDLPPEMKEIQRLLKLALDERYSSLKRCGY--- 239 Query: 245 ASADLPKKEILRAGQIINEETAKGNHDLRKLLLFHAMALKLHHAIELLETQGLSALRVYL 304 DL L A + GN K L A+++ +A+ + E G++ + Sbjct: 240 ---DLGSNRSLSALLRLRMVVLGGNRRAAKPLF---TAIRITYALNIFEAHGVTPFLKFC 293 Query: 305 KKLYEEAKTGSTRASKELFLDRRMKKALALLIQAKELGIDHPKMEVLKELVKEQLSKKEN 364 ++ ++ G ++ DR A+A A+ G++HPK+ L++ V+ Sbjct: 294 ERTSKKKGVGVAELFEQ---DRNFTGAIARAKAAQAAGMEHPKIPKLEDAVRGA-----R 345 Query: 365 SKIIVFTNYRETARKVVEELTKEGIKAKRFVGQATKENDRGMSQREQKLILDSFARGEFN 424 K +VFT+YR++ + L GI + +G+A ++G+ QR+Q + F G ++ Sbjct: 346 GKALVFTSYRDSVDLIHSRLKAAGINSGILIGKA---GEKGLKQRKQVETVAKFRDGGYD 402 Query: 425 VLVATSVGEEGLDVPEVDLVVFYEPVPSAIRSVQRRGRTGRQKPGRVVILIAQGTRDEAY 484 VLV+T VGEEGLD+ EV+LV+FY+ VPS+IR VQRRGRTGR+ GR+++L+A+GT DEAY Sbjct: 403 VLVSTRVGEEGLDISEVNLVIFYDNVPSSIRYVQRRGRTGRKDAGRLIVLMAKGTIDEAY 462 Query: 485 YWSSKHK 491 YW + K Sbjct: 463 YWIGRRK 469 >pir||T39190 probable ATP-dependent RNA helicase - fission yeast (Schizosaccharomyces pombe) >gi|6014424|emb|CAB57423.1| (AL121764) putative ATP-dependent RNA helicase [Schizosaccharomyces pombe] Length = 839 Score = 242 bits (611), Expect = 1e-62 Identities = 169/557 (30%), Positives = 285/557 (50%), Gaps = 21/557 (3%) Query: 14 RLYQELIYAKCKERNCLIVLPTGLGKTIIAMMIADYRLNKYGGK-VLMLAPTKPLVLQHA 72 R YQ I K N L+ LPTGLGKT IA ++ L + ++ +APTKPLV Q Sbjct: 74 RDYQFNIVQKALFENVLVALPTGLGKTFIAAVVMMNYLRWFPKSYIVFMAPTKPLVTQQM 133 Query: 73 ETFRKFFNLPPEKIVALTGEVSPSERVKAWNRAKVIIATPQTVENDLLTGKINLEDVVLV 132 E K +P + L+G V + R + + V TPQT+ ND+ G + + + Sbjct: 134 EACYKITGIPKSQTAELSGHVPVTTRNQYYQSRNVFFVTPQTILNDIKHGICDRTRISCL 193 Query: 133 IFDEAHRAVGNYAYVYIAREYLNQAKNPHVIGLTASPGSSQEKILEVLRNLGIEHIEYRS 192 + DEAHR+ GNYAYV + KN ++ L+A+PG+ E I V+ +L I IE R+ Sbjct: 194 VIDEAHRSTGNYAYVEVVHLLSLSNKNFRILALSATPGNKLEAIQNVIDSLHISRIEIRT 253 Query: 193 ENSPDVKPYVQGIKFEWIKVELPGLYKEVRKLLRDMLRDSLKPLAEAGLIESASA-DLPK 251 ENS D+ YVQ + ++ V+L ++R +L L+ L + +A D+ Sbjct: 254 ENSIDISQYVQKKEVDFFPVDLSAEITDIRDRFSSILEPMLQKLNKGNYYRIQNAKDITS 313 Query: 252 KEILRAGQ---IINEETAKGNHDLRKLLLFHAMALKLHHAIELLETQGLSALRVYLKKLY 308 +++A Q ++ + N L F A+A + + LL G+ L+++ Sbjct: 314 FTVVQAKQAFLAMSGQNFPANQKWDILNTFDALA-TFAYPLNLLLNHGIRPFYQKLREVE 372 Query: 309 EEAKTGSTRASKELFLD---RRMKKALALLIQAKELGIDHPKMEVLKELVKEQLSKKE-- 363 EE G + K + R + + +L++ + + HPK+E L+ +V E K++ Sbjct: 373 EECFVGRSGYKKRIINHENYRPLMDDIEILLRDQSF-VGHPKLEHLERIVTEYFEKEQTK 431 Query: 364 NSKIIVFTNYRETARKVVEELTK--EGIKAKRFVGQATKENDRGMSQREQKLILDSFARG 421 +++I++F R +A +++ L K ++ F+GQ+ GMSQ+ Q + F +G Sbjct: 432 DTRIMIFVEIRSSAEEILRFLGKFYPNVRPAIFIGQSAVRKAAGMSQKLQNETVKQFQKG 491 Query: 422 EFNVLVATSVGEEGLDVPEVDLVVFYEPVPSAIRSVQRRGRTGRQKPGRVVILIAQGTRD 481 E N L+ATS+GEEGLD+ EVD+++ Y+ S IR +QR GRTGR++ G + +L+ +G ++ Sbjct: 492 EVNTLIATSIGEEGLDIGEVDMIICYDASASPIRMLQRMGRTGRKRKGYIYMLLTRG-KE 550 Query: 482 EAYYWSSKHKERQMRETIRMVSQAIKREKQLSLESY-VKKDTEKEMEREEKEERKGEREG 540 EA + +K R +++ I R LS +SY + + + + + E E E Sbjct: 551 EAKWERAKDAYRTLQDNI-----VSGRGLSLSEKSYRILPEKFRPVCDKRVIEIPKENEE 605 Query: 541 VKVVVDSRELRSEVVKR 557 V V +LR+++ K+ Sbjct: 606 VVVAPKKVQLRTKIKKK 622 >gb|AAF55897.1| (AE003735) CG7922 gene product [Drosophila melanogaster] Length = 1383 Score = 235 bits (592), Expect = 2e-60 Identities = 167/558 (29%), Positives = 279/558 (49%), Gaps = 42/558 (7%) Query: 14 RLYQELIYAKCKERNCLIVLPTGLGKTIIAMMIADYRLNKY--GGKVLMLAPTKPLVLQH 71 R YQ+ I +N L+VLPTGLGKT IA ++ Y ++ GK++ +APT+PLV Q Sbjct: 59 RSYQQTIVQSALFKNTLVVLPTGLGKTFIAAVVM-YNFYRWYPKGKIVFMAPTRPLVSQQ 117 Query: 72 AETFRKFFNLPPEKIVALTGEVSPSERVKAWNRAKVIIATPQTVENDLLTG----KINLE 127 +K P E V LTG++ +R + W +V ATPQ V +D+L Sbjct: 118 IHASQKIMPFPSEDTVQLTGQLPRPKRAELWASKRVFFATPQVVHSDMLEADGECSFPFG 177 Query: 128 DVVLVIFDEAHRAVGNYAYVYIAREYLNQAKNPHVIGLTASPGSSQEKILEVLRNLGIEH 187 + L++ DEAHRA G YAY +A + + + ++ L+A+PG + E + V RNL I + Sbjct: 178 SIKLIVVDEAHRAKGRYAYTQVADCLMARNRYFRMLALSATPGRTMEDVAAVCRNLYISN 237 Query: 188 IEYRSENSPDVKPYVQGIKFEWIKVELPGLYKEVRKLLRDMLRDSLKPLAEAGLIESASA 247 ++ R + S DV+PY+ I V L KE R+ L ++ L+ L EA + + Sbjct: 238 LQVRWDTSIDVQPYIHRRTIRTIVVSLKERIKEPRERLLQIIEPYLRQLMEAEIFKGNKG 297 Query: 248 DLPKKEILRAGQIINEETAKGNH--DLRKLLLFHAMALKLHHAIELLETQGLSALRVYL- 304 + + +L + E +A+G D ++ AM + ++H+++L+E G LRV++ Sbjct: 298 TVSRNSLLFEQKSFVERSAQGQRHPDHNIIMGNFAMCISMYHSLDLMERHG---LRVFVN 354 Query: 305 --------KKLYEEAKTGSTRASKELFLDRRMKKALALLIQA----------KELGIDHP 346 ++ + A+ G+ R E L A +L H Sbjct: 355 NFDADDDGREKFVLARDGNLRNLVEQVRQELGANPLDYTTHAMTNGEVPPLPSDLDFGHA 414 Query: 347 KMEVLKELVKEQLSKKENSKIIVFTNYRETARKVVEELTKEG--IKAKRFVGQ-ATKEND 403 K E L++++ + +S+ IVF YRE+ + L + ++ + FVGQ +T Sbjct: 415 KYEKLRQVLVQHFQANPDSRAIVFCEYRESVMLIHRLLLQHRPVLRPRCFVGQGSTVGAS 474 Query: 404 RGMSQREQKLILDSFARGEFNVLVATSVGEEGLDVPEVDLVVFYEPV-PSAIRSVQRRGR 462 ++Q++Q I+ F G NVLVATS+GEEGLDV EV+++V ++ + R +QR GR Sbjct: 475 YALTQKQQLQIMTDFRSGTSNVLVATSIGEEGLDVGEVEMIVCFDICSTNPTRFIQRIGR 534 Query: 463 TGRQKPGRVVILIAQGTRDEAYYWSSKHKERQMRETIRMVSQAIK-----REKQLSLESY 517 TGR+K G VV+L+ +G + +K++ ++ + S +K + ++ + Sbjct: 535 TGRKKNGEVVMLVTEGREQQVLKDVLANKDQINKKLLN--SSVVKLSLYEQNPRMVPSKF 592 Query: 518 VKKDTEKEMEREEKEERK 535 K EK ME +E+ K Sbjct: 593 QPKCEEKHMEPVAEEKPK 610 >gb|AAF79368.1|AC007887_27 (AC007887) F15O4.40 [Arabidopsis thaliana] Length = 1587 Score = 205 bits (515), Expect = 2e-51 Identities = 164/542 (30%), Positives = 244/542 (44%), Gaps = 102/542 (18%) Query: 14 RLYQELIYAKCKERNCLIVLPTGLGKTIIAMMIADYRLNKY--GGKVLMLAPTKPLVLQH 71 R YQ I N L+ LPTGLGKT+IA ++ Y ++ GK++ AP++PLV+Q Sbjct: 206 RDYQFAITKTALFSNTLVALPTGLGKTLIAAVVM-YNYFRWFPQGKIVFAAPSRPLVMQQ 264 Query: 72 AETFRKFFNLPPEKIVALTGEVSPSERVKAWNRAKVIIATPQTVENDLLTGKINL----- 126 E +P E + LTG+ PS+R W +V TPQ +E D+ +G Sbjct: 265 IEACHNIVGIPQEWTIDLTGQTCPSKRAFLWKSKRVFFVTPQVLEKDIQSGDARFVLKLP 324 Query: 127 --------------EDVVLVIFDEAHRAVGNYAYVYIAREYLNQAKNPHVIGLTASPGSS 172 +V ++ DEAHRA+GNY+Y + RE + ++ LTA+PGS Sbjct: 325 LVHKDCPFSGTCLTNYLVCLVIDEAHRALGNYSYCVVVRELMAVPIQLRILALTATPGSK 384 Query: 173 QEKILEVLRNLGIEHIEYRSENSPDVKPYVQGIKFEWIKVELPGL-----YKEVRKLLRD 227 + I ++ NL I +EYR+E+ DV PYV K E I+V+ + +V K L Sbjct: 385 TQAIQGIIDNLQISTLEYRNESDHDVCPYVHDRKLEVIEVQAEQVPLGQDADDVSKRLFH 444 Query: 228 MLRDSLKPLAEAGLIESASADLPKKEILRAGQIINEETAKG----NH-DLRKLLLFHAMA 282 ++R L G L E+L A + G NH D+ A Sbjct: 445 VIRPYAVRLKNFG--------LSPHEVLMARDKFRQAPLPGLPHVNHGDVESCF---AAL 493 Query: 283 LKLHHAIELLETQGLSALRVYLKKLYEEAKTGSTRASKELFLDRRMKKALALLIQAKELG 342 + L+H +LL + G +R + L E+ K G D RM K L+ Q G Sbjct: 494 ITLYHIRKLLSSHG---IRPAYEMLEEKLKEGPFARLMSKNEDIRMTK--LLMQQRLSHG 548 Query: 343 IDHPKMEVLKEL-------VKEQLSKKENSKIIVFTNYRETA------------------ 377 PK+ + E+ V QL + N +I+F R Sbjct: 549 APSPKLSKMLEILVDHFIDVSTQLVLQLNIDMILFYGCRSERSEDITGHYFLKFQRKRKV 608 Query: 378 ---------------------------RKVVEELTKEG--IKAKRFVGQATKENDRGMSQ 408 R ++ L+ G +KA F+GQ++ + +G SQ Sbjct: 609 SIIVVCFPLFSCSSYFFVSIHPITLLFRDIMNALSNIGDMVKATEFIGQSSGKTLKGQSQ 668 Query: 409 REQKLILDSFARGEFNVLVATSVGEEGLDVPEVDLVVFYEPVPSAIRSVQRRGRTGRQKP 468 + Q+ +L+ F G FNV+VATS+GEEGLD+ EVDLV+ ++ S +R +QR GRTGR+ Sbjct: 669 KIQQAVLEKFRAGGFNVIVATSIGEEGLDIMEVDLVICFDANVSPLRMIQRMGRTGRKNN 728 Query: 469 GR 470 GR Sbjct: 729 GR 730 >gi|6322192 Mph1p [Saccharomyces cerevisiae] >gi|731905|sp|P40562|YIS2_YEAST PUTATIVE ATP-DEPENDENT RNA HELICASE YIR002C >gi|626348|pir||S48436 probable RNA helicase YIR002c - yeast (Saccharomyces cerevisiae) >gi|557851|emb|CAA86204.1| (Z38062) orf, len: 993, CAI: 0.16 possible ATP dependent RNA helicase [Saccharomyces cerevisiae] Length = 993 Score = 192 bits (483), Expect = 1e-47 Identities = 163/621 (26%), Positives = 288/621 (46%), Gaps = 87/621 (14%) Query: 3 TMYLRKELLQPRLYQELIYAKCKERNCLIVLPTGLGKTIIA--MMIADYRLNKYGGKVLM 60 + Y+ + R YQ I K +N L +PTG+GKT IA +M+ +R K K++ Sbjct: 77 SFYVYPTNYEVRDYQYTIVHKSLFQNTLCAIPTGMGKTFIASTVMLNYFRWTKKA-KIIF 135 Query: 61 LAPTKPLVLQHAETFRKFFNLPPEKIVALTGEVSPSERVKAWNRAKVIIATPQTVENDLL 120 APT+PLV Q + +P ++ L + S R + W +V ATPQ VENDL Sbjct: 136 TAPTRPLVAQQIKACLGITGIPSDQTAILLDK-SRKNREEIWANKRVFFATPQVVENDLK 194 Query: 121 TGKINLEDVVLVIFDEAHRAVGNYAYVYIAREYLNQAKNPHVIGLTASPGSSQEKILEVL 180 G ++ +D+V ++ DEAHRA G+ AY + + + ++ LTA+P S E + EV+ Sbjct: 195 RGVLDPKDIVCLVIDEAHRATGSSAYTNVVKFIDRFNSSYRLLALTATPASDLEGVQEVV 254 Query: 181 RNLGIEHIEYRSENSPDVKPYVQGIKFEWIKVELPGLYKEVRKLLRDMLRDSLKPLAEAG 240 NL I IE R+E S D+ Y++ K E I+V L +++ + L ++ L+ E G Sbjct: 255 NNLDISKIEIRTEESMDIVKYMKKRKKEKIEVPLLLEIEDIIEQLGMAVKPVLQQAIELG 314 Query: 241 LIESASADLPK--KEILRAGQIINEETAKGNHDLRKLLLFHAMALKLHHAIELLETQGLS 298 + E K + ++ +II T R + + + ++ L+ G+ Sbjct: 315 IYEECDPSQINAFKAMQQSQKIIANPTIPEGIKWRNFFILQLLN-NVGQMLKRLKIYGIR 373 Query: 299 ALRVYLKKLYEE------AKTGSTRASKELFLDRRMK----KALALLIQAKELGIDHPKM 348 Y + E K + + + E + +K + L K +G H K+ Sbjct: 374 TFFNYFQNKCTEFTTKYNLKKSTNKIAAEFYYHPILKNIKNQCENYLSDPKFVG--HGKL 431 Query: 349 EVLKELVKEQLSKK-ENSKIIVFTNYRETARKVV---EELTKEGIKAKRFVGQATKE--- 401 + +++ + + K+ +S++I+FT RE+A ++V + + + I+ F+GQA + Sbjct: 432 QCVRDELMDFFQKRGSDSRVIIFTELRESALEIVKFIDSVADDQIRPHIFIGQARAKEGF 491 Query: 402 --------------------------------------NDR--------GMSQREQ---- 411 ND+ G S+ Q Sbjct: 492 DEVKYTRKHAPKGRKKVERLHRQEQEKFLEAERTKRAANDKLERSARRTGSSEEAQISGM 551 Query: 412 -----KLILDSFARGEFNVLVATSVGEEGLDVPEVDLVVFYEPVPSAIRSVQRRGRTGRQ 466 K ++ +F +GE+NVLV TS+GEEGLD+ EVDL++ Y+ S I+++QR GRTGR+ Sbjct: 552 NQKMQKEVIHNFKKGEYNVLVCTSIGEEGLDIGEVDLIICYDTTSSPIKNIQRMGRTGRK 611 Query: 467 KPGRVVILIAQGTRDEAYYWSSKHKERQMRETIRMVSQAI--KREKQLSLESYVKKDTEK 524 + G++V+L + +E+Y + ++ + + + Q I K+ ++ E + + E Sbjct: 612 RDGKIVLLFSS---NESYKFERAMEDYSTLQAL-ISKQCIDYKKSDRIIPEDIIPECHET 667 Query: 525 EMEREEKEERKGEREGVKVVV 545 + ++ E E E V V+ Sbjct: 668 LITINDENEIINEMEDVDEVI 688 >pir||C71203 probable DNA excision repair protein - Pyrococcus horikoshii >gi|3258335|dbj|BAA31018.1| (AP000007) 90aa long hypothetical DNA excision repair protein [Pyrococcus horikoshii] Length = 90 Score = 157 bits (393), Expect = 4e-37 Identities = 78/89 (87%), Positives = 87/89 (97%) Query: 664 MARREQEERRREVRVRGEKKALTLAERQRLIVESLPHVSATLAKRLLKHFGSVERVFTAS 723 MA+REQEER+REVR+RGEKKALTLAERQR+IVESLP+VS TLA+RLL+HFGSVE+VFTAS Sbjct: 1 MAKREQEERKREVRIRGEKKALTLAERQRMIVESLPNVSTTLARRLLRHFGSVEKVFTAS 60 Query: 724 VPELMKVEGIGEKIAREIRRVITSPYTED 752 VPELMKVEGIGEKIAREIRRVITSPY E+ Sbjct: 61 VPELMKVEGIGEKIAREIRRVITSPYIEE 89 >gi|7657516 RNA helicase [Homo sapiens] >gi|4405795|gb|AAD19826.1| (AF038963) RNA helicase [Homo sapiens] Length = 925 Score = 155 bits (387), Expect = 2e-36 Identities = 149/571 (26%), Positives = 262/571 (45%), Gaps = 52/571 (9%) Query: 12 QPRLYQ-ELIYAKCKERNCLIVLPTGLGKTIIAMMIADYRLNKYG----GKVLMLAPTKP 66 +PR YQ EL K +N +I PTG GKT ++++I ++ L K+ GKV+ A P Sbjct: 242 KPRNYQLELALPAMKGKNTIICAPTGCGKTFVSLLICEHHLKKFPQGQKGKVVFFANQIP 301 Query: 67 LVLQHAETFRKFFNLPPEKIVALTGEVS---PSERVKAWNRAKVIIATPQTVENDLLTGK 123 + Q F K+F ++ ++G + P E++ N +II TPQ + N+L G Sbjct: 302 VYEQQKSVFSKYFERHGYRVTGISGATAENVPVEQIVENN--DIIILTPQILVNNLKKGT 359 Query: 124 I-NLEDVVLVIFDEAHRAVGNYAYVYIAREYLNQAKN------PHVIGLTASPGSSQEK- 175 I +L L+IFDE H + Y I YL+Q P VIGLTAS G K Sbjct: 360 IPSLSIFTLMIFDECHNTSKQHPYNMIMFNYLDQKLGGSSGPLPQVIGLTASVGVGDAKN 419 Query: 176 -------ILEVLRNLGIEHIEYRSENSPDVKPYVQGIKFEWIKVELPGLYKEVRKLLRDM 228 I ++ +L I N +++ V + + KVE + + + ++ + Sbjct: 420 TDEALDYICKLCASLDASVIATVKHNLEELEQVVYKPQKFFRKVE-SRISDKFKYIIAQL 478 Query: 229 LRDS-------LKPLAEAGLIESASADLPKKE-----ILRAGQIIN-EETAKGNHDLRKL 275 +RD+ K L I++ K E + +A + + + + + L Sbjct: 479 MRDTESLAKRICKDLENLSQIQNREFGTQKYEQWIVTVQKACMVFQMPDKDEESRICKAL 538 Query: 276 LLFHAMALKLHHAIELLETQGLSALRVYLKKLYEEAKTGSTRASKELFLDRRMKKALALL 335 L+ + K + A+ + E + YLK + + ++ R +K L Sbjct: 539 FLYTSHLRKYNDALIISEHARMKDALDYLKDFFSNVRAAGFEEIEQDLTQRFEEKLQELE 598 Query: 336 IQAKELGIDHPKMEVLKELVKEQLSKKENSKIIVFTNYR---ETARKVVEELTKEG-IKA 391 +++ ++PK+E L +++E+ + I+F R + + +E K +K Sbjct: 599 SVSRDPSNENPKLEDLCFILQEEYHLNPETITILFVKTRALVDALKNWIEGNPKLSFLKP 658 Query: 392 KRFVGQATKENDRGMSQREQKLILDSF-ARGEFNVLVATSVGEEGLDVPEVDLVVFYEPV 450 G+ + GM+ QK ILD+F A G+ N+L+ATSV +EG+D+ + +LV+ YE V Sbjct: 659 GILTGRGKTNQNTGMTLPAQKCILDAFKASGDHNILIATSVADEGIDIAQCNLVILYEYV 718 Query: 451 PSAIRSVQRRGRTGRQKPGRVVILIAQGTRDEAYYWSSKHKERQMRETIRMV---SQAIK 507 + I+ +Q RGR GR + + +L + E + +KE+ M ++I + +A+ Sbjct: 719 GNVIKMIQTRGR-GRARGSKCFLLTSNAGVIEKEQ-INMYKEKMMNDSILRLQTWDEAVF 776 Query: 508 REKQLSL---ESYVKKDTEKEMEREEKEERK 535 REK L + E +++ EK +KE +K Sbjct: 777 REKILHIQTHEKFIRDSQEKPKPVPDKENKK 807 >pir||C72622 hypothetical protein APE1436 - Aeropyrum pernix (strain K1) >gi|5105119|dbj|BAA80433.1| (AP000061) 254aa long hypothetical protein [Aeropyrum pernix] Length = 254 Score = 153 bits (382), Expect = 8e-36 Identities = 81/209 (38%), Positives = 132/209 (62%), Gaps = 1/209 (0%) Query: 542 KVVVDSRELRSEVVKRLKTLGVKIEVKTLDVGDYIISDEVAIERKSANDFIQSIIDGRLF 601 +V VD RE RS V L++LGV++ K L +GDY++SD + +ERK+++DF +S+ DGRLF Sbjct: 20 RVYVDVREERSPVPSILESLGVQVIPKQLPMGDYLVSDSIIVERKTSSDFAKSLFDGRLF 79 Query: 602 DQVKRLKDSYPRPVVIVEGQLYGIR-NVHPNAIRGAIASIVIDFGVPIIFSSNPEETANY 660 +Q RL + Y +IVEG R ++ A+A++ +D+G+ ++ + +P+ TA Sbjct: 80 EQASRLAEHYETVFIIVEGPPVPRRYRGRERSLYAAMAALQLDYGIRLMNTMDPKGTALV 139 Query: 661 IFFMARREQEERRREVRVRGEKKALTLAERQRLIVESLPHVSATLAKRLLKHFGSVERVF 720 I +AR E + + + + + + E Q I++S P + A+R+L+ FGS+ER F Sbjct: 140 IESLARLSTREGGQRIVIHKKPRLSDVREWQLYILQSFPGIGRRTAERILERFGSLERFF 199 Query: 721 TASVPELMKVEGIGEKIAREIRRVITSPY 749 TAS E+ KVEGIGEK A EI++++ +PY Sbjct: 200 TASKAEISKVEGIGEKRAEEIKKILMTPY 228 >gi|11545922 melanoma differentiation associated protein-5 [Homo sapiens] >gi|11344594|gb|AAG34368.1|AF095844_1 (AF095844) melanoma differentiation associated protein-5 [Homo sapiens] Length = 1025 Score = 143 bits (356), Expect = 9e-33 Identities = 179/682 (26%), Positives = 291/682 (42%), Gaps = 137/682 (20%) Query: 11 LQPRLYQ-ELIYAKCKERNCLIVLPTGLGKTIIAMMIADYRLNKYG-----GKVLMLAPT 64 LQ R YQ E+ + +N +I LPTG GKT +A+ IA L+K GKV++L Sbjct: 306 LQLRPYQMEVAQPALEGKNIIICLPTGSGKTRVAVYIAKDHLDKKKKASEPGKVIVLVNK 365 Query: 65 KPLVLQHAETFRKFFNLPPEK---IVALTGE----VSPSERVKAWNRAKVIIATPQTVEN 117 LV Q FRK F +K ++ L+G+ +S E VK+ + +II+T Q +EN Sbjct: 366 VLLVEQ---LFRKEFQPFLKKWYRVIGLSGDTQLKISFPEVVKSCD---IIISTAQILEN 419 Query: 118 DLLT------GKINLEDVVLVIFDEAHRAVGNYAYVYIAREYLNQA-KN----------- 159 LL + L D L+I DE H Y I R YL Q KN Sbjct: 420 SLLNLENGEDAGVQLSDFSLIIIDECHHTNKEAVYNNIMRHYLMQKLKNNRLKKENKPVI 479 Query: 160 --PHVIGLTASPG--------SSQEKILEVLRNLGIEHIEYRSENSPDVKPYVQGI--KF 207 P ++GLTASPG ++E IL++ NL I+ EN +K +Q KF Sbjct: 480 PLPQILGLTASPGVGGATKQAKAEEHILKLCANLDAFTIKTVKENLDQLKNQIQEPCKKF 539 Query: 208 EWIKVELPGLYKEVRKLLRDMLRDS----LKPLAEAGL--IESASADLPKKEILRAGQII 261 +KE KLL M R + P+++ G E + + KK Sbjct: 540 AIADATREDPFKE--KLLEIMTRIQTYCQMSPMSDFGTQPYEQWAIQMEKKA-------- 589 Query: 262 NEETAKGNHDLRKLLLFHAMALKLHHAIELLETQGLSALRVYLKKLYEEAKTGSTRA--- 318 KGN RK + K + A+++ +T + +L+ Y E K Sbjct: 590 ---AKKGN---RKERVCAEHLRKYNEALQINDTIRMIDAYTHLETFYNEEKDKKFAVIED 643 Query: 319 --------------------SKELFLDRRMKKALALLIQ--------AKELGIDHPKMEV 350 K L LD + + L + A+ ++ K+ Sbjct: 644 DSDEGGDDEYCDGDEDEDDLKKPLKLDETDRFLMTLFFENNKMLKRLAENPEYENEKLTK 703 Query: 351 LKELVKEQLSKKENS-KIIVFTNYRETARKVVEELTKE------GIKAKRFVGQATKEND 403 L+ + EQ ++ E S + I+FT R++A + + +T+ G+KA +G Sbjct: 704 LRNTIMEQYTRTEESARGIIFTKTRQSAYALSQWITENEKFAEVGVKAHHLIGAGHSSEF 763 Query: 404 RGMSQREQKLILDSFARGEFNVLVATSVGEEGLDVPEVDLVVFYEPVPSAIRSVQRRGRT 463 + M+Q EQK ++ F G+ N+L+AT+V EEGLD+ E ++V+ Y V + I VQ RGR Sbjct: 764 KPMTQNEQKEVISKFRTGKINLLIATTVAEEGLDIKECNIVIRYGLVTNEIAMVQARGR- 822 Query: 464 GRQKPGRVVILIAQGTRDEAYYWSSKHKERQMRETIRMVSQAIKREKQLSLESYVKKDTE 523 R V++ G+ + + +E+ M + I V + + E Y K E Sbjct: 823 ARADESTYVLVAHSGSGVIEHETVNDFREKMMYKAIHCV-------QNMKPEEYAHKILE 875 Query: 524 KEMEREEKEERKGEREGVKVVVDSRELRS----------------EVVKRLKTLGVKIEV 567 +M+ +++ K +R K ++ L + V++++ + + E Sbjct: 876 LQMQSIMEKKMKTKRNIAKHYKNNPSLITFLCKNCSVLACSGEDIHVIEKMHHVNMTPEF 935 Query: 568 KTLDVGDYIISDEVAIERKSAN 589 K L YI+ + A+++K A+ Sbjct: 936 KEL----YIVRENKALQKKCAD 953 >gb|AAK41026.1| RNA helicase (ATP dependent)/eIF4A (eiF4A) [Sulfolobus solfataricus] Length = 233 Score = 141 bits (352), Expect = 3e-32 Identities = 75/215 (34%), Positives = 128/215 (58%), Gaps = 5/215 (2%) Query: 541 VKVVVDSRELRSEVVKRLKTLGVKIEVKTLDVGDYIISDEVAIERKSANDFIQSIIDGRL 600 +++ D RE S + + LK LG+ + L V DY+I+D+VA+ERKS ND + S+ D R Sbjct: 3 IRIYADDREKASGIPELLKELGITVIFSQLTVADYVITDDVAVERKSVNDLVNSVFDKRF 62 Query: 601 FDQVKRLKDSYPRPVVIVEGQLYGIRNVHP--NAIRGAIASIVIDFGVPIIFSSNPEETA 658 FDQ+ RL + Y P+++VEG + IR + AI A+ S ID+ V + +S + ++TA Sbjct: 63 FDQISRLSEVYRFPILLVEGDINDIRKITEKWRAINNALISATIDYDVKVFYSRDKKDTA 122 Query: 659 NYIFFMARREQ--EERRREVRVRGEKKALTLAERQRLIVESLPHVSATLAKRLLKHFGSV 716 + +A + Q E + + + + K ++++ Q IVES P+V + LA+RLL FG++ Sbjct: 123 EVLKKIAEKFQFGENKSNRISLHNKAKLESVSDIQLYIVESFPNVGSILAERLLLKFGTI 182 Query: 717 ERVFTASVPELMKVEGIGEKIAREIRRVITSPYTE 751 + + AS+ EL K G K A +I +++ + Y++ Sbjct: 183 QNICNASISELEKALG-SRKKAEDIYKILRTHYSK 216 >emb|CAB57574.1| (Y18930) ATP-dependent RNA helicase, eIF-4A family [Sulfolobus solfataricus] Length = 233 Score = 141 bits (352), Expect = 3e-32 Identities = 75/215 (34%), Positives = 128/215 (58%), Gaps = 5/215 (2%) Query: 541 VKVVVDSRELRSEVVKRLKTLGVKIEVKTLDVGDYIISDEVAIERKSANDFIQSIIDGRL 600 +++ D RE S + + LK LG+ + L V DY+I+D+VA+ERKS ND + S+ D R Sbjct: 3 IRIYADDREKASGIPELLKELGITVIFSQLTVADYVITDDVAVERKSVNDLVNSVFDKRF 62 Query: 601 FDQVKRLKDSYPRPVVIVEGQLYGIRNVHP--NAIRGAIASIVIDFGVPIIFSSNPEETA 658 FDQ+ RL + Y P+++VEG + IR + AI A+ S ID+ V + +S + ++TA Sbjct: 63 FDQISRLSEVYRFPILLVEGDINDIRKITEKWRAINNALISATIDYDVKVFYSRDKKDTA 122 Query: 659 NYIFFMARREQ--EERRREVRVRGEKKALTLAERQRLIVESLPHVSATLAKRLLKHFGSV 716 + +A + Q E + + + + K ++++ Q IVES P+V + LA+RLL FG++ Sbjct: 123 EVLKKIAEKFQFGENKSNRISLHNKAKLESVSDIQLYIVESFPNVGSILAERLLLKFGTI 182 Query: 717 ERVFTASVPELMKVEGIGEKIAREIRRVITSPYTE 751 + + AS+ EL K G K A +I +++ + Y++ Sbjct: 183 QNICNASISELEKALG-SRKKAEDIYKILRTHYSK 216 >gb|AAG09428.1|AF181119_1 (AF181119) RNA helicase [Sus scrofa] Length = 940 Score = 132 bits (330), Expect = 1e-29 Identities = 140/566 (24%), Positives = 254/566 (44%), Gaps = 52/566 (9%) Query: 11 LQPRLYQ-ELIYAKCKERNCLIVLPTGLGKTIIAMMIADYRLNKYG----GKVLMLAPTK 65 L+PR YQ EL +N +I PTG GKT ++++I ++ L K+ GKV+ A Sbjct: 239 LKPRKYQLELALPAQNGKNTIICAPTGCGKTFVSLLICEHHLKKFPRGRKGKVVFFAIQL 298 Query: 66 PLVLQHAETFRKFFNLPPEKIVALTGEVSPSERVKAW-NRAKVIIATPQTVENDLLTGKI 124 P+ Q F K F K+ ++G S + V+ + +II TPQ + N L G I Sbjct: 299 PVYEQQKSVFSKHFERLGYKVAGISGATSDTVCVEQIVENSDIIILTPQILVNCLTNGTI 358 Query: 125 -NLEDVVLVIFDEAHRAVGNYAYVYIAREYLNQAKN------PHVIGLTASPG------- 170 +L L+IFDE H + Y I YL++ P VIGLTAS G Sbjct: 359 PSLSVFTLMIFDECHNTSKQHPYNVIMFSYLDRKLGGSSDSLPQVIGLTASVGVGDAKNK 418 Query: 171 -SSQEKILEVLRNLGIEHIEYRSENSPDVKPYVQGIKFEWIKVEL----------PGLYK 219 + E I ++ +L I +N +++ V + + KVEL L Sbjct: 419 AEATEYICKLCASLDTSVIATVRDNLEELEEVVYKPQKFFRKVELRTTDRFKCIISQLMM 478 Query: 220 EVRKLLRDMLRDSLKPLAEAGLIESASADLPKKEILRAGQIINEETA-------KGNHDL 272 E+ L + + + L + GL + +++ ++ + + +E A + Sbjct: 479 EIESLAKSIFEE-LGTITLGGLFQIQNSNFGTQKYEQWIVKVQKECAVFQMPDKDKESRI 537 Query: 273 RKLLLFHAMALKLHH-AIELLETQGLSALRVYLKKLYEEAKTGSTRASKELFLDRRMKKA 331 K L + L++++ A+ + E + YLK + + ++ R +K Sbjct: 538 CKALFSYMSHLRIYNDALIINEHARMKDALDYLKDFFRNIRAAGFDEIEQDLTQRFEEKL 597 Query: 332 LALLIQAKELGIDHPKMEVLKELVKEQLSKKENSKIIVFTNYR---ETARKVVEELTKEG 388 L + + ++PK+ L +++E+ ++ I+F R + +K ++E K Sbjct: 598 QELESISIDPSNENPKLRDLCFILQEEYHLNPETRTILFVKTRALVDALKKWIKENPKLS 657 Query: 389 -IKAKRFVGQATKENDRGMSQREQKLILDSFARGEFN-VLVATSVGEEGLDVPEVDLVVF 446 +K G+ + GM+ QK +LD+F + N +L+ TSV +EG+D+ + +LV+ Sbjct: 658 FLKPSILTGRGKTNQNIGMTLPAQKCVLDTFRTDKDNKILITTSVADEGIDIAQCNLVIL 717 Query: 447 YEPVPSAIRSVQRRGRTGRQKPGRVVILIAQGTRDEAYYWSSKHKERQMRETIRMV---S 503 YE V + I+ +Q RGR GR + + +L A + + +KE M I ++ Sbjct: 718 YEYVGNVIKMIQTRGR-GRARGSKCFLLTANADLIDKEK-MNMYKEEMMNGAILILQTWD 775 Query: 504 QAIKREK--QLSLESYVKKDTEKEME 527 +A+ +EK Q+ + + +D + + E Sbjct: 776 EAVFKEKIHQIQIREKIIRDNQGKPE 801 >dbj|BAB13818.1| (AK021416) unnamed protein product [Homo sapiens] Length = 678 Score = 131 bits (327), Expect = 2e-29 Identities = 137/569 (24%), Positives = 254/569 (44%), Gaps = 52/569 (9%) Query: 11 LQPRLYQ-ELIYAKCKERNCLIVLPTGLGKTIIAMMIADYRLNKY-GGKVLMLAPTKPLV 68 ++ R YQ E+I + +N +I LPTG GKT A +A L G KV++L LV Sbjct: 1 MELRSYQWEVIMPALEGKNIIIWLPTGAGKTRAAAYVAKRHLETVDGAKVVVLVNRVHLV 60 Query: 69 LQHAETFRKFFNLPPEKIVALTGEVSPSERVKAWNRAK-VIIATPQTVENDLLTGK---- 123 QH E FR+ + + L+G++ P R ++I T + ++ L + + Sbjct: 61 TQHGEEFRRMLD-GRWTVTTLSGDMGPRAGFGHLARCHDLLICTAELLQMALTSPEEEEH 119 Query: 124 INLEDVVLVIFDEAHRAVGNYAYVYIAREYLNQAKN-----PHVIGLTASPGSSQEK--- 175 + L L++ DE H + Y I +YL P V+GLTASPG+ Sbjct: 120 VELTVFSLIVVDECHHTHKDTVYNVIMSQYLELKLQRAQPLPQVLGLTASPGTGGASKLD 179 Query: 176 -----ILEVLRNLGIEHIEYRSENSPDVKPYVQGI--KFEWIKVELPGLYKEVRKLLRDM 228 +L++ NL I P ++ + Q ++ + ++ K L D Sbjct: 180 GAINHVLQLCANLDTWCIMSPQNCCPQLQEHSQQPCKQYNLCHRRSQDPFGDLLKKLMDQ 239 Query: 229 LRDSLKPLAEAGLIESASADLPKKEILRAGQIINEETAKGNHDLRKLLLFHAM----ALK 284 + D L+ L + ++++++ ++E A +++ H AL Sbjct: 240 IHDHLEM---PELSRKFGTQMYEQQVVK----LSEAAALAGLQEQRVYALHLRRYNDALL 292 Query: 285 LHHAIELLETQGLSALRVYLKKLYEEAKTGSTRASKEL---FLDRRMKKALALLIQAKEL 341 +H + ++ L+AL+ + + + KT A + L F DR+ + L Sbjct: 293 IHDTVRAVDA--LAALQDFYHREHV-TKTQILCAERRLLALFDDRKNE-----LAHLATH 344 Query: 342 GIDHPKMEVLKELVKEQLSKKENSKIIVFTNYRETARKVVEELTKE------GIKAKRFV 395 G ++PK+E+L+++++ Q S + + I+FT R++A ++ L ++ I+A+ + Sbjct: 345 GPENPKLEMLEKILQRQFSSSNSPRGIIFTRTRQSAHSLLLWLQQQQGLQTVDIRAQLLI 404 Query: 396 GQATKENDRGMSQREQKLILDSFARGEFNVLVATSVGEEGLDVPEVDLVVFYEPVPSAIR 455 G M+QR+Q+ ++ F G N+LVATSV EEGLD+P ++VV Y + + I Sbjct: 405 GAGNSSQSTHMTQRDQQEVIQKFQDGTLNLLVATSVAEEGLDIPHCNVVVRYGLLTNEIS 464 Query: 456 SVQRRGRTGRQKPGRVVILIAQGTRDEAYYWSSKHKERQMRETIRMVSQAIKREKQLSLE 515 VQ RGR + + +G+R+ ++ E M + + V + + E Q + Sbjct: 465 MVQARGRAWADQ-SVYAFVATEGSRELKRELINEALETLMEQAVAAVQKMDQAEYQAKIR 523 Query: 516 SYVKKDTEKEMEREEKEERKGEREGVKVV 544 + K + + E + ++ V+ V Sbjct: 524 DLQQAALTKRAAQAAQRENQRQQFPVEHV 552 >gi|11499994 DNA repair protein, putative [Archaeoglobus fulgidus] >gi|7483288|pir||C69552 DNA repair protein homolog - Archaeoglobus fulgidus >gi|2650671|gb|AAB91244.1| (AE001108) DNA repair protein, putative [Archaeoglobus fulgidus] Length = 208 Score = 119 bits (295), Expect = 1e-25 Identities = 76/211 (36%), Positives = 121/211 (57%), Gaps = 17/211 (8%) Query: 543 VVVDSRELRSEVVKRLKTLGVKIEVKTLDVGDYIISD---EVAIERKSANDFIQSIIDGR 599 + VDSRE +V++LK+LG+ + VK L+VGDY+I EV +ERK NDFI SIIDGR Sbjct: 2 IFVDSRE-PERIVEKLKSLGLDVYVKRLEVGDYLIKHSIYEVPVERKDVNDFISSIIDGR 60 Query: 600 LFDQVKRLKDSYPRPVVIVEGQLYGI---RNVHPNAIRGAIASIVIDFG----VPIIFSS 652 LF Q L YP ++ V G + R + +A+ GA+ S+ I VP++F + Sbjct: 61 LFRQCHLLSSRYPLSILAVIGDIDEAVEERGISRSAVIGAMVSMAIKNAQGQVVPLVFKN 120 Query: 653 NPEETANYIFFMARREQEERRREVRVRGEKKALTLAERQRLIVESLPHVSATLAKRLLKH 712 + F +A + + R + ++ + + + ++ ++P + A++LL + Sbjct: 121 EDD------FCLALKSIDSRVSQGDLKILPRLKSHENPKIAMLTAIPGIGEKKAEKLLDY 174 Query: 713 FGSVERVFTASVPELMKVEGIGEKIAREIRR 743 FGS++R+ AS+ EL +V+GIGEK AREI R Sbjct: 175 FGSIQRIANASIAELKRVDGIGEKKAREIYR 205 >sp|Q09884|YC9A_SCHPO HYPOTHETICAL HELICASE C584.10C IN CHROMOSOME III >gi|2130449|pir||S62524 probable RNA helicase/ribonuclease SPAC8A4.08c - fission yeast (Schizosaccharomyces pombe) >gi|7491257|pir||T39130 hypothetical protein SPAC8A4.08c - fission yeast (Schizosaccharomyces pombe) >gi|7493293|pir||T41432 ribonuclease - fission yeast (Schizosaccharomyces pombe) >gi|1052539|emb|CAA91518.1| (Z66569) unknown [Schizosaccharomyces pombe] >gi|4456833|emb|CAB37423.1| (AL032824) ribonuclease [Schizosaccharomyces pombe] Length = 1374 Score = 113 bits (281), Expect = 6e-24 Identities = 135/542 (24%), Positives = 240/542 (43%), Gaps = 85/542 (15%) Query: 5 YLRKELLQPRLYQELIYAKCKERNCLIVLPTGLGKTIIAMMIADYRL---------NKYG 55 +L +LL R YQ+ +Y ++N L+V+ TG GKT++A+ + +L N Sbjct: 6 FLLPQLL--RKYQQDVYNIASKQNTLLVMRTGAGKTLLAVKLIKQKLEEQILIQESNLEH 63 Query: 56 GKVLMLAPTK-PLVLQHAETFRKFFNLPPEKIVALTGEVS--PSERV--KAWNRAKVIIA 110 K+ + K PLV Q AE R P K+ GE+S SE++ + VI+ Sbjct: 64 KKISVFLVNKVPLVFQQAEYIRSQL---PAKVGMFYGELSIEMSEQLLTNIILKYNVIVI 120 Query: 111 TPQTVENDLLTGKINLEDVVLVIFDEAHRAVGNYAYVYIAREYLNQAKN---------PH 161 T L G +++ D+ L+IFDE H A+GN AY I ++ ++AK P Sbjct: 121 TADLFYLFLARGFLSINDLNLIIFDECHHAIGNDAYARIMNDFYHRAKAVLSKKHFTLPR 180 Query: 162 VIGLTASPGSSQEKILEVLRNLGIEHIEYRSENSPDVKPYVQGIKFEWIKVELPGLYKEV 221 + G+TASP + ++ + H Y+ E D K +V + EL + Sbjct: 181 IFGMTASPFTGKKG--------NLYHRLYQWEQLFDSKAHVVS------ENELADYF--- 223 Query: 222 RKLLRDMLRDSLKPLAEAGLIESASADLPKK--EILRAGQIINEETAKGNHDLRKLLLFH 279 L + + L+ S + KK E L+ ++I+ + + L+ Sbjct: 224 ------CLPEESYVMYSNKLVVPPSDSIIKKCEETLQGCKLISRAVKTALAETIDMGLWF 277 Query: 280 AMALKLHHAIELLETQGLSALRVYLKKLYEEAKTGSTRASKELFLDRRMKKALALLIQAK 339 + L + ++ +ET K+L ++A +EL +DR K + Sbjct: 278 GEQVWL-YLVDFVET----------KRLKKKALGKQLSDDEELAIDR--LKIFVEDWKNN 324 Query: 340 ELGIDHPKMEV------------LKELVKEQLSKKENSKIIVFTNYRETARKV---VEEL 384 + + P++ V L EL+K K ++ + ++F + TA + ++ L Sbjct: 325 KYSDNGPRIPVFDSTDVTDKVFKLLELLKATYRKSDSVRTVIFVERKATAFTLSLFMKTL 384 Query: 385 TKEGIKAKRFVGQA-TKENDRGMSQREQKLILDSFARGEFNVLVATSVGEEGLDVPEVDL 443 I+A F+G + + + M+ R QK L F G++NVL+AT+V EEG+DVP +L Sbjct: 385 NLPNIRAHSFIGHGPSDQGEFSMTFRRQKDTLHKFKTGKYNVLIATAVAEEGIDVPSCNL 444 Query: 444 VVFYEPVPSAIRSVQRRGRTGRQKPGRVVILIAQGTRDEAYYWSSKHKERQMRETIRMVS 503 V+ + + + VQ RGR R + +I + T + + H+E+ ++ + +S Sbjct: 445 VIRFNICRTVTQYVQSRGR-ARAMASKFLIFL--NTEELLIHERILHEEKNLKFALSELS 501 Query: 504 QA 505 + Sbjct: 502 NS 503 >pir||T32534 hypothetical protein F15B10.2 - Caenorhabditis elegans >gi|2662588|gb|AAB88350.1| (AF036696) contains similarity to helicases [Caenorhabditis elegans] Length = 1037 Score = 111 bits (276), Expect = 2e-23 Identities = 140/608 (23%), Positives = 245/608 (40%), Gaps = 86/608 (14%) Query: 4 MYLRKELLQPRLYQELIYAKCKERNCLIVLPTGLGKTIIAMMIADYRLNKYGG-----KV 58 ++ +++L +EL + +N ++ PTG GKT+IA I K Sbjct: 285 IHRQRQLCLRNYQEELCQVALQGKNTIVTAPTGSGKTVIAANIIKEHFESRSSEGKRFKA 344 Query: 59 LMLAPTKPLVLQHAETFRKFFNLPPEKIVALTGEVSPSERVKAWNRAKVIIATPQTVEND 118 L + P ++ Q A + + + + + P+ V +I+ATPQ + N Sbjct: 345 LFMTPNSMILNQQAASISSYLDHVYHTQIIQGSDNVPTRNVI--QSKDLIVATPQMIVNL 402 Query: 119 LLTGKINLED-----------VVLVIFDEAHRAVGNYAYVYIAREYLNQAKN-------- 159 + +L+D ++ FDE H V N Y I REY + KN Sbjct: 403 CNEHRNSLDDESRLDQFFLSTFTIIFFDECHNTVKNSPYSNIMREY-HYLKNMGNMPEGH 461 Query: 160 --PHVIGLTASPGSSQEKILEVLRN--------LGIEHIEYRSENSPDVKPYVQGIKFEW 209 P +IGLTAS G+ + +RN + ++ + +N +++ Y + + Sbjct: 462 SLPQIIGLTASLGTGDKNDCLQVRNYIAGLCASMDVKDLSIVKDNLEELRGYSPIVPDKV 521 Query: 210 IKVE-------------LPGLYKEVRKLLRDMLRDSLKPLAEAGLIESASADLPKKEILR 256 + E L + +EV L+R LR+ + + IE+ D Sbjct: 522 LLCERSTDGPIGMFTNRLTLMMQEVEGLIRTALRNEHIGIEQRRQIETTERDFRPDSSFL 581 Query: 257 AGQIINEETAKGNHDLRKLLLFHAMALK-------LHHAIELLETQGLSAL-------RV 302 E N ++ L + + ++ A+++L+ + V Sbjct: 582 DPPADKEHAGYQNWVCNQMNLVSGTSFRETGTRTIINEALDVLKECFCTLSYNINFHPEV 641 Query: 303 YLKKLYEEAKTGSTRASKELFLDRRMKKALALLIQAKELGIDHPKMEVLKELVKEQLSKK 362 L L +E + + + + R ++ L+ ++P + + + EQ ++ Sbjct: 642 ALNYLKDEMEYRTPNFTVNMI--RIWERYHNQLVGTGSA--ENPMISKTVQYIVEQNLQR 697 Query: 363 ENSKIIVF--TNYRETARKVV----EELTKEGIKAKRFVG---QATKENDRGMSQREQKL 413 +S+ I+F T Y T V EEL GIK++ G D S+++Q Sbjct: 698 ADSRTIIFVRTRYEATILNKVLNSNEELLMLGIKSEWMSGLNKSTASSADISASKQKQME 757 Query: 414 ILDSFARGEFNVLVATSVGEEGLDVPEVDLVVFYEPVPSAIRSVQRRGRTGRQKPGRVVI 473 L FA GE +LV+TSV EEGLDVPE LV+ Y + I VQRRGR V+I Sbjct: 758 KLKMFADGEIRILVSTSVAEEGLDVPECSLVIKYNYATNEIAHVQRRGRGRALNSECVLI 817 Query: 474 LIAQGTRDEAYYWSSKHKERQMRETIRMVS-------QAIKREKQLSLESYVKKDTEKEM 526 + RD+ +++ KE M ETI ++ + + E +++DT+K Sbjct: 818 TNSIALRDQES--NNRDKESLMSETISLIQNSPAEFRKCVDEESNKIWPRILREDTDKAQ 875 Query: 527 EREEKEER 534 + EE+ R Sbjct: 876 KIEEQINR 883 >gi|4885217 excision repair cross-complementing rodent repair deficiency, complementation group 4; Excision-repair, complementing defective, in Chinese hamster,; xeroderma pigmentosum, complementation group F [Homo sapiens] >gi|11430345|ref|XP_007800.1| excision repair cross-complementing rodent repair deficiency, complementation group 4 [Homo sapiens] >gi|1905924|gb|AAB50174.1| (L77890) DNA repair protein [Homo sapiens] Length = 916 Score = 97.5 bits (239), Expect = 5e-19 Identities = 81/316 (25%), Positives = 151/316 (47%), Gaps = 31/316 (9%) Query: 444 VVFYEPVPSAIRSVQ--RRGRTGRQKPGRVVILIAQGTRDEAYYWSSKHKERQ-----MR 496 VV Y+ + +R ++ R R G KP RV LI G+ +E Y ++ KE++ +R Sbjct: 578 VVLYDAELTFVRQLEIYRASRPG--KPLRVYFLIYGGSTEEQRYLTALRKEKEAFEKLIR 635 Query: 497 ETIRMVSQAIKREKQLSLESYVKKDTEKEMEREEKEERKGEREGVK--VVVDSRELRSEV 554 E MV + + + V+ ++ + ++ E+ G + +VVD RE RSE+ Sbjct: 636 EKASMVVPEEREGRDETNLDLVRGTASADVSTDTRKAGGQEQNGTQQSIVVDMREFRSEL 695 Query: 555 VKRLKTLGVKIEVKTLDVGDYIISDEVAIERKSANDFIQSIIDGRLFDQVKRLKDSYPRP 614 + G+ IE TL+VGDYI++ E+ +ERKS +D I S+ +GRL+ Q + Y RP Sbjct: 696 PSLIHRRGIDIEPVTLEVGDYILTPEMCVERKSISDLIGSLNNGRLYSQCISMSRYYKRP 755 Query: 615 VVIVE------------GQLYGIRNVHPNAIRGAIASIVIDF-GVPIIFSSNPEETANYI 661 V+++E G L+ + + N I + + + F + I++ +P TA Sbjct: 756 VLLIEFDPSKPFSLTSRGALF--QEISSNDISSKLTLLTLHFPRLRILWCPSPHATAELF 813 Query: 662 FFMAR-REQEERRREVRVRGEKKALTLAER----QRLIVESLPHVSATLAKRLLKHFGSV 716 + + + Q + + + + + L +E+ + + +P V+A + L+ H ++ Sbjct: 814 EELKQSKPQPDAATALAITADSETLPESEKYNPGPQDFLLKMPGVNAKNCRSLMHHVKNI 873 Query: 717 ERVFTASVPELMKVEG 732 + S EL + G Sbjct: 874 AELAALSQDELTSILG 889 >sp|Q92889|XPF_HUMAN DNA-REPAIR PROTEIN COMPLEMENTING XP-F CELL (XERODERMA PIGMENTOSUM GROUP F COMPLEMENTING PROTEIN) (DNA EXCISION REPAIR PROTEIN ERCC-4) Length = 905 Score = 97.5 bits (239), Expect = 5e-19 Identities = 81/316 (25%), Positives = 151/316 (47%), Gaps = 31/316 (9%) Query: 444 VVFYEPVPSAIRSVQ--RRGRTGRQKPGRVVILIAQGTRDEAYYWSSKHKERQ-----MR 496 VV Y+ + +R ++ R R G KP RV LI G+ +E Y ++ KE++ +R Sbjct: 567 VVLYDAELTFVRQLEIYRASRPG--KPLRVYFLIYGGSTEEQRYLTALRKEKEAFEKLIR 624 Query: 497 ETIRMVSQAIKREKQLSLESYVKKDTEKEMEREEKEERKGEREGVK--VVVDSRELRSEV 554 E MV + + + V+ ++ + ++ E+ G + +VVD RE RSE+ Sbjct: 625 EKASMVVPEEREGRDETNLDLVRGTASADVSTDTRKAGGQEQNGTQQSIVVDMREFRSEL 684 Query: 555 VKRLKTLGVKIEVKTLDVGDYIISDEVAIERKSANDFIQSIIDGRLFDQVKRLKDSYPRP 614 + G+ IE TL+VGDYI++ E+ +ERKS +D I S+ +GRL+ Q + Y RP Sbjct: 685 PSLIHRRGIDIEPVTLEVGDYILTPEMCVERKSISDLIGSLNNGRLYSQCISMSRYYKRP 744 Query: 615 VVIVE------------GQLYGIRNVHPNAIRGAIASIVIDF-GVPIIFSSNPEETANYI 661 V+++E G L+ + + N I + + + F + I++ +P TA Sbjct: 745 VLLIEFDPSKPFSLTSRGALF--QEISSNDISSKLTLLTLHFPRLRILWCPSPHATAELF 802 Query: 662 FFMAR-REQEERRREVRVRGEKKALTLAER----QRLIVESLPHVSATLAKRLLKHFGSV 716 + + + Q + + + + + L +E+ + + +P V+A + L+ H ++ Sbjct: 803 EELKQSKPQPDAATALAITADSETLPESEKYNPGPQDFLLKMPGVNAKNCRSLMHHVKNI 862 Query: 717 ERVFTASVPELMKVEG 732 + S EL + G Sbjct: 863 AELAALSQDELTSILG 878 >gb|AAB07689.1| (U64315) DNA repair endonuclease subunit [Homo sapiens] Length = 905 Score = 94.8 bits (232), Expect = 3e-18 Identities = 80/316 (25%), Positives = 150/316 (47%), Gaps = 31/316 (9%) Query: 444 VVFYEPVPSAIRSVQ--RRGRTGRQKPGRVVILIAQGTRDEAYYWSSKHKERQ-----MR 496 VV Y+ + +R ++ R R G KP RV LI G+ +E Y ++ KE++ +R Sbjct: 567 VVLYDAELTFVRQLEIYRASRPG--KPLRVYFLIYGGSTEEQRYLTALRKEKEAFEKLIR 624 Query: 497 ETIRMVSQAIKREKQLSLESYVKKDTEKEMEREEKEERKGEREGVK--VVVDSRELRSEV 554 E MV + + + V+ ++ + ++ E+ G + +VVD RE RSE+ Sbjct: 625 EKASMVVPEEREGRDETNLDLVRGTASADVSTDTRKAGGQEQNGTQQSIVVDMREFRSEL 684 Query: 555 VKRLKTLGVKIEVKTLDVGDYIISDEVAIERKSANDFIQSIIDGRLFDQVKRLKDSYPRP 614 + + IE TL+VGDYI++ E+ +ERKS +D I S+ +GRL+ Q + Y RP Sbjct: 685 PSLIHRRDIDIEPVTLEVGDYILTPEMCVERKSISDLIGSLNNGRLYSQCISMSRYYKRP 744 Query: 615 VVIVE------------GQLYGIRNVHPNAIRGAIASIVIDF-GVPIIFSSNPEETANYI 661 V+++E G L+ + + N I + + + F + I++ +P TA Sbjct: 745 VLLIEFDPSKPFSLTSRGALF--QEISSNDISSKLTLLTLHFPRLRILWCPSPHATAELF 802 Query: 662 FFMAR-REQEERRREVRVRGEKKALTLAER----QRLIVESLPHVSATLAKRLLKHFGSV 716 + + + Q + + + + + L +E+ + + +P V+A + L+ H ++ Sbjct: 803 EELKQSKPQPDAATALAITADSETLPESEKYNPGPQDFLLKMPGVNAKNCRSLMHHVKNI 862 Query: 717 ERVFTASVPELMKVEG 732 + S EL + G Sbjct: 863 AELAALSQDELTSILG 878 >dbj|BAA89229.1| (AB017635) ERCC4 [Cricetulus griseus] Length = 913 Score = 90.9 bits (222), Expect = 5e-17 Identities = 90/344 (26%), Positives = 151/344 (43%), Gaps = 51/344 (14%) Query: 318 ASKELFLDRRMKKALALLIQAKELGIDHPKMEVLKELVKEQLSKKENSKIIVFTNYRETA 377 A E FL R +K +A+E+ ++ K + K +K K+ R + Sbjct: 423 AGAEAFLLRLYRKTFEKDSKAEEVWVNLRKGDGPKRTMKSDKRPKDTKN-----KERAST 477 Query: 378 RKVVEELTKEGIKAKRFVGQATKENDRGMSQREQKLILDSFARG----------EFNVLV 427 +K + K + + +G A + + G ++ +Q+ S G + N+ Sbjct: 478 KKGAPKRKKRELTLTQVMGTAEEPPEEGAAEEDQQRQATSSPEGCGGEIQHEAFDLNLSS 537 Query: 428 ATSVG--EEGLDV-------------------PEVDLVVFYEPVPSAIRSVQ--RRGRTG 464 ++ G +E L + E VV Y+ + +R ++ R R G Sbjct: 538 DSAYGILKEPLTIIHPLVGCSDPYALTRVLHEVEPRYVVLYDAELTFVRQLEIYRASRPG 597 Query: 465 RQKPGRVVILIAQGTRDEAYYWSSKHKERQ-----MRETIRMV---SQAIKREKQLSL-E 515 KP RV LI G+ +E Y ++ KE++ +RE MV + + E L L Sbjct: 598 --KPLRVYFLIYGGSTEEQRYLTALRKEKEAFEKLIREKASMVVPEEREGRDETNLDLAR 655 Query: 516 SYVKKDTEKEMEREEKEERKGEREGVKVVVDSRELRSEVVKRLKTLGVKIEVKTLDVGDY 575 V D + + +E G + + VVD RE RSE+ + G+ IE TL+VGDY Sbjct: 656 GTVSTDAPADTRKAGGQEHNGTQPSI--VVDMREFRSELPSLIHRRGIDIEPVTLEVGDY 713 Query: 576 IISDEVAIERKSANDFIQSIIDGRLFDQVKRLKDSYPRPVVIVE 619 I++ E+ +ERKS +D I S+ GRL+ Q + Y RPV+++E Sbjct: 714 ILTPELCVERKSVSDLIGSLNSGRLYSQCLAMSRYYRRPVLLIE 757 >gb|AAC03240.1| (AC004155) ERCC4_MOUSE [Mus musculus] Length = 917 Score = 88.5 bits (216), Expect = 2e-16 Identities = 60/187 (32%), Positives = 98/187 (52%), Gaps = 15/187 (8%) Query: 444 VVFYEPVPSAIRSVQ--RRGRTGRQKPGRVVILIAQGTRDEAYYWSSKHKERQMRETI-- 499 VV Y+ + +R ++ R R G KP RV LI G+ +E Y ++ KE++ E + Sbjct: 579 VVLYDAELTFVRQLEIYRASRPG--KPLRVYFLIYGGSTEEQRYLTALRKEKEAFEKLIR 636 Query: 500 RMVSQAIKREKQLSLESYVKK-------DTEKEMEREEKEERKGEREGVKVVVDSRELRS 552 S + E++ E+ + D + + +E+ G + + VVD RE RS Sbjct: 637 EKASMVVPEEREGRDETNLDLARGSAALDAPTDTRKAGGQEQNGTQSSI--VVDMREFRS 694 Query: 553 EVVKRLKTLGVKIEVKTLDVGDYIISDEVAIERKSANDFIQSIIDGRLFDQVKRLKDSYP 612 E+ + G+ IE TL+VGDYI++ E+ +ERKS +D I S+ GRL+ Q + Y Sbjct: 695 ELPSLIHRRGIDIEPVTLEVGDYILTPELCVERKSVSDLIGSLHSGRLYSQCLAMSRYYR 754 Query: 613 RPVVIVE 619 RPV+++E Sbjct: 755 RPVLLIE 761 >gi|7657064 excision repair cross-complementing rodent repair deficiency, complementation group 4 [Mus musculus] >gi|6063149|gb|AAF03157.1|AF189285_1 (AF189285) DNA repair endonuclease XPF [Mus musculus] Length = 917 Score = 88.5 bits (216), Expect = 2e-16 Identities = 60/187 (32%), Positives = 98/187 (52%), Gaps = 15/187 (8%) Query: 444 VVFYEPVPSAIRSVQ--RRGRTGRQKPGRVVILIAQGTRDEAYYWSSKHKERQMRETI-- 499 VV Y+ + +R ++ R R G KP RV LI G+ +E Y ++ KE++ E + Sbjct: 579 VVLYDAELTFVRQLEIYRASRPG--KPLRVYFLIYGGSTEEQRYLTALRKEKEAFEKLIR 636 Query: 500 RMVSQAIKREKQLSLESYVKK-------DTEKEMEREEKEERKGEREGVKVVVDSRELRS 552 S + E++ E+ + D + + +E+ G + + VVD RE RS Sbjct: 637 EKASMVVPEEREGRDETNLDLARGSAALDAPTDTRKAGGQEQNGTQSSI--VVDMREFRS 694 Query: 553 EVVKRLKTLGVKIEVKTLDVGDYIISDEVAIERKSANDFIQSIIDGRLFDQVKRLKDSYP 612 E+ + G+ IE TL+VGDYI++ E+ +ERKS +D I S+ GRL+ Q + Y Sbjct: 695 ELPSLIHRRGIDIEPVTLEVGDYILTPELCVERKSVSDLIGSLHSGRLYSQCLAMSRYYR 754 Query: 613 RPVVIVE 619 RPV+++E Sbjct: 755 RPVLLIE 761 >pir||T46312 hypothetical protein DKFZp434J1111.1 - human (fragment) >gi|6808358|emb|CAB70840.1| (AL137608) hypothetical protein [Homo sapiens] Length = 398 Score = 87.4 bits (213), Expect = 5e-16 Identities = 71/274 (25%), Positives = 133/274 (47%), Gaps = 13/274 (4%) Query: 273 RKLLLFHAMALKLHHAIELLETQGLSALRVYLKKLYEEAKTGSTRASKELFLDRRMKKAL 332 + L L+ + K + A+ + E + YLK + + ++ R +K Sbjct: 9 KALFLYTSHLRKYNDALIISEHARMKDALDYLKDFFSNVRAAGFDEIEQDLTQRFEEKLQ 68 Query: 333 ALLIQAKELGIDHPKMEVLKELVKEQLSKKENSKIIVFTNYR---ETARKVVEELTKEG- 388 L +++ ++PK+E L +++E+ + I+F R + + +E K Sbjct: 69 ELESVSRDPSNENPKLEDLCFILQEEYHLNPETITILFVKTRALVDALKNWIEGNPKLSF 128 Query: 389 IKAKRFVGQATKENDRGMSQREQKLILDSF-ARGEFNVLVATSVGEEGLDVPEVDLVVFY 447 +K G+ + GM+ QK ILD+F A G+ N+L+ATSV +EG+D+ + +LV+ Y Sbjct: 129 LKPGILTGRGKTNQNTGMTLPAQKCILDAFKASGDHNILIATSVADEGIDIAQCNLVILY 188 Query: 448 EPVPSAIRSVQRRGRTGRQKPGRVVILIAQGTRDEAYYWSSKHKERQMRETIRMV---SQ 504 E V + I+ +Q RGR GR + + +L + E + +KE+ M ++I + + Sbjct: 189 EYVGNVIKMIQTRGR-GRARGSKCFLLTSNAGVIEKEQ-INMYKEKMMNDSILRLQTWDE 246 Query: 505 AIKREKQLSL---ESYVKKDTEKEMEREEKEERK 535 A+ REK L + E +++ EK +KE +K Sbjct: 247 AVFREKILHIQTHEKFIRDSQEKPKPVPDKENKK 280 >gi|11526480 RNA helicase [Homo sapiens] Length = 590 Score = 86.2 bits (210), Expect = 1e-15 Identities = 63/179 (35%), Positives = 89/179 (49%), Gaps = 17/179 (9%) Query: 12 QPRLYQ-ELIYAKCKERNCLIVLPTGLGKTIIAMMIADYRLNKY----GGKVLMLAPTKP 66 +PR YQ EL K +N +I PTG GKT ++++I ++ L K+ GKV+ A P Sbjct: 242 KPRNYQLELALPAMKGKNTIICAPTGCGKTFVSLLICEHHLKKFPQGQKGKVVFFANQIP 301 Query: 67 LVLQHAETFRKFFNLPPEKIVALTG---EVSPSERVKAWNRAKVIIATPQTVENDLLTGK 123 + Q F K+F ++ ++G E P E++ N +II TPQ + N+L G Sbjct: 302 VYEQQKSVFSKYFERHGYRVTGISGATAENVPVEQIVENN--DIIILTPQILVNNLKKGT 359 Query: 124 I-NLEDVVLVIFDEAHRAVGNYAYVYIAREYLNQAKN------PHVIGLTASPGSSQEK 175 I +L L+IFDE H + Y I YL+Q P VIGLTAS G K Sbjct: 360 IPSLSIFTLMIFDECHNTSKQHPYNMIMFNYLDQKLGGSSGPLPQVIGLTASVGVGDAK 418 >gb|AAF01274.1|AF160500_1 (AF160500) repair endonuclease [Arabidopsis thaliana] >gi|9759161|dbj|BAB09717.1| (AB010072) repair endonuclease [Arabidopsis thaliana] Length = 956 Score = 83.1 bits (202), Expect = 1e-14 Identities = 81/347 (23%), Positives = 152/347 (43%), Gaps = 39/347 (11%) Query: 436 LDVPEVDLVVFYEPVPSAIRSVQ-RRGRTGRQKPGRVVILIAQGTRDEAYYWSSKHKERQ 494 LD+ + +++ Y P +R ++ + +K I + T + + S + + Sbjct: 612 LDILKPSVIIVYHPDMGFVRELEVYKAENPLRKLKVYFIFYDESTEVQKFEASIRRENEA 671 Query: 495 MRETIRMVSQAIKREKQLSL-------ESYVKKDTEKEMEREEKEERKGEREGVKVVVDS 547 IR S I Q L + T+ + R+ ++ E+E +V+VD Sbjct: 672 FESLIRQKSSMIIPVDQDGLCMGSNSSTEFPASSTQNSLTRKAGGRKELEKE-TQVIVDM 730 Query: 548 RELRSEVVKRLKTLGVKIEVKTLDVGDYIISDEVAIERKSANDFIQSIIDGRLFDQVKRL 607 RE S + L G+KI TL+VGDYI+S + +ERKS D QS GRLF QV+ + Sbjct: 731 REFMSSLPNVLHQKGMKIIPVTLEVGDYILSPSICVERKSIQDLFQSFTSGRLFHQVEMM 790 Query: 608 KDSYPRPVVIVE---GQLYGIR-------NVHPNAIRGAIASIVIDF-GVPIIFSSNPEE 656 Y PV+++E + + + +V P I ++ +V+ F + +++S + Sbjct: 791 SRYYRIPVLLIEFSQDKSFSFQSSSDISDDVTPYNIISKLSLLVLHFPRLRLLWSRSLHA 850 Query: 657 TAN-YIFFMARREQEERRREVRV-------------RGEKKALTLAERQRLIVESLPHVS 702 TA + + +++ + R +RV R E + E + LP VS Sbjct: 851 TAEIFTTLKSNQDEPDETRAIRVGVPSEEGIIENDIRAENYNTSAVE----FLRRLPGVS 906 Query: 703 ATLAKRLLKHFGSVERVFTASVPELMKVEGIGEKIAREIRRVITSPY 749 + +++ S+ + + V L ++ G G K+A+ +R + + Y Sbjct: 907 DANYRSIMEKCKSLAELASLPVETLAELMG-GHKVAKSLREFLDAKY 952 >dbj|BAA28847.1| (AB009461) MUS38 [Neurospora crassa] Length = 892 Score = 81.9 bits (199), Expect = 2e-14 Identities = 72/265 (27%), Positives = 116/265 (43%), Gaps = 29/265 (10%) Query: 433 EEGLDVPEVDLVVFYEPVPSAIRSVQRRGRTGRQKPGRVVILIAQGTRDEAYYWSSKHKE 492 E L+ + ++ YEP S IR V+ + + RV L G+ +E Y SS +E Sbjct: 530 EHVLEEVKPKYIIMYEPDASFIRRVEVYRSSHNDRNVRVYFLYYGGSVEEQRYLSSVRRE 589 Query: 493 RQMRETIRMVSQAIKREKQLSLESYVKKDTEKEMEREEKEE-------RKGEREGVKVVV 545 + +++ + ++ +S+ +D E R K + +VVV Sbjct: 590 KDA--FTKLIRERASMSIVMTTDSHGVEDPESAFLRTINTRIAGGGKLAKATAQPPRVVV 647 Query: 546 DSRELRSEVVKRLKTLGVKIEVKTLDVGDYIISDEVAIERKSANDFIQSIIDGRLFDQVK 605 D RE RS + L + I L VGDYI+S + +ERKS +D I S DGRL+ Q + Sbjct: 648 DVREFRSSLPSLLHGRSMVIVPCMLTVGDYILSPNICVERKSVSDLISSFKDGRLYAQCE 707 Query: 606 RLKDSYPRPVVIVE----------------GQLYGIRNVHPNAIRGAI-ASIVIDFGVP- 647 + Y P++++E G L + + A R A+ S ++ P Sbjct: 708 TMFQHYRNPMLLIEFDQNKSFTLEPFADLSGSLRSVNPENAGAQRLAVQKSCLLTLAFPK 767 Query: 648 --IIFSSNPEETANYIFFMARREQE 670 II+SS+P ETA + E+E Sbjct: 768 LRIIWSSSPYETAEIFERLKALEEE 792 >gb|AAF81910.1|AF277377_1 (AF277377) 5' repair endonuclease [Arabidopsis thaliana] Length = 956 Score = 80.4 bits (195), Expect = 7e-14 Identities = 80/347 (23%), Positives = 151/347 (43%), Gaps = 39/347 (11%) Query: 436 LDVPEVDLVVFYEPVPSAIRSVQ-RRGRTGRQKPGRVVILIAQGTRDEAYYWSSKHKERQ 494 LD+ + +++ Y P +R ++ + +K I + T + + S + + Sbjct: 612 LDILKPSVIIVYHPDMGFVRELEVYKAENPLRKLKVYFIFYDESTEVQKFEASIRRENEA 671 Query: 495 MRETIRMVSQAIKREKQLSL-------ESYVKKDTEKEMEREEKEERKGEREGVKVVVDS 547 IR S I Q L + T+ + R+ ++ E+E +V+VD Sbjct: 672 FESLIRQKSSMIIPVDQDGLCMGSNSSTEFPASSTQNSLTRKAGGRKEVEKE-TQVIVDM 730 Query: 548 RELRSEVVKRLKTLGVKIEVKTLDVGDYIISDEVAIERKSANDFIQSIIDGRLFDQVKRL 607 RE S + L G+KI TL+VGDYI+S + +ERKS D QS GRLF QV+ + Sbjct: 731 REFMSSLPNVLHQKGMKIIPVTLEVGDYILSPSICVERKSIQDLFQSFTSGRLFHQVEMM 790 Query: 608 KDSYPRPVVIVE---GQLYGIR-------NVHPNAIRGAIASIVIDF-GVPIIFSSNPEE 656 Y PV+++E + + + +V P I ++ +V+ + +++S + Sbjct: 791 SRYYRIPVLLIEFSQDKSFSFQSSSDISDDVTPYNIISKLSLLVLHSPRLRLLWSRSLHA 850 Query: 657 TAN-YIFFMARREQEERRREVRV-------------RGEKKALTLAERQRLIVESLPHVS 702 TA + + +++ + R +RV R E + E + LP VS Sbjct: 851 TAEIFTTLKSNQDEPDETRAIRVGVPSEEGIIENDIRAENYNTSAVE----FLRRLPGVS 906 Query: 703 ATLAKRLLKHFGSVERVFTASVPELMKVEGIGEKIAREIRRVITSPY 749 + +++ S+ + + V L ++ G G K+A+ +R + + Y Sbjct: 907 DANYRSIMEKCKSLAELASLPVETLAELMG-GHKVAKSLREFLDAKY 952 >gb|AAF45938.1| (AE003430) mei-9 gene product [Drosophila melanogaster] Length = 961 Score = 77.3 bits (187), Expect = 6e-13 Identities = 56/201 (27%), Positives = 104/201 (50%), Gaps = 14/201 (6%) Query: 433 EEGLDVPEVDLVVFYEPVPSAIRSVQRRGRTGRQKPG---RVVILIAQGTRDEAYYWSSK 489 E L+ + VV Y +AIR ++ R P +V LI T +E Y +S Sbjct: 574 EHMLEQLQPHYVVMYNMNVTAIRQLEVFEARRRLPPADRMKVYFLIHARTVEEQAYLTSL 633 Query: 490 HKERQMRETI-----RMVSQAIKREKQ----LSLESYVKKDTEKEMEREEK--EERKGER 538 +E+ E I +MV + K L L++Y + T++ + + + + + Sbjct: 634 RREKAAFEFIIDTKSKMVIPKYQDGKTDEAFLLLKTYDDEPTDENAKSRQAGGQAPQATK 693 Query: 539 EGVKVVVDSRELRSEVVKRLKTLGVKIEVKTLDVGDYIISDEVAIERKSANDFIQSIIDG 598 E KV+VD RE RS++ + G+++ T+ +GDYI++ ++ +ERKS +D I S+ G Sbjct: 694 ETPKVIVDMREFRSDLPCLIHKRGLEVLPLTITIGDYILTPDICVERKSISDLIGSLNSG 753 Query: 599 RLFDQVKRLKDSYPRPVVIVE 619 RL++Q +++ Y +P++++E Sbjct: 754 RLYNQCVQMQRHYAKPILLIE 774 >sp|Q24087|MEI9_DROME MEI-9 PROTEIN (MEIOTIC-9 PROTEIN) >gi|2133695|pir||S58936 meiotic recombination protein mei-9 - fruit fly (Drosophila melanogaster) >gi|924919|gb|AAC46917.1| (U27181) MEI-9 [Drosophila melanogaster] >gi|1585596|prf||2201389A mei-9 gene [Drosophila melanogaster] Length = 926 Score = 75.3 bits (182), Expect = 2e-12 Identities = 55/201 (27%), Positives = 103/201 (50%), Gaps = 14/201 (6%) Query: 433 EEGLDVPEVDLVVFYEPVPSAIRSVQRRGRTGRQKPG---RVVILIAQGTRDEAYYWSSK 489 E L+ + VV Y + IR ++ R P +V LI T +E Y +S Sbjct: 531 EHMLEQLQPHYVVMYNMNVTPIRQLEVFEARRRLPPADRMKVYFLIHARTVEEQAYLTSL 590 Query: 490 HKERQMRETI-----RMVSQAIKREKQ----LSLESYVKKDTEKEMEREEK--EERKGER 538 +E+ E I +MV + K L L++Y + T++ + + + + + Sbjct: 591 RREKAAFEFIIDTKSKMVIPKYQDGKTDEAFLLLKTYDDEPTDENAKSRQAGGQAPQATK 650 Query: 539 EGVKVVVDSRELRSEVVKRLKTLGVKIEVKTLDVGDYIISDEVAIERKSANDFIQSIIDG 598 E KV+VD RE RS++ + G+++ T+ +GDYI++ ++ +ERKS +D I S+ G Sbjct: 651 ETPKVIVDMREFRSDLPCLIHKRGLEVLPLTITIGDYILTPDICVERKSISDLIGSLNSG 710 Query: 599 RLFDQVKRLKDSYPRPVVIVE 619 RL++Q +++ Y +P++++E Sbjct: 711 RLYNQCVQMQRHYAKPILLIE 731 >emb|CAB70217.1| (AL033535) Similarity to Yeast DNA repair protein RAD16 (SW:RAD16_SCHPO)~cDNA EST EMBL:Z14466 comes from this gene~cDNA EST yk636b12.5 comes from this gene~cDNA EST yk86a4.3 comes from this gene~cDNA EST yk131g2.3 comes from this gene~cDNA EST yk86a4.5> >gi|6782250|emb|CAA93766.2| (Z69902) Similarity to Yeast DNA repair protein RAD16 (SW:RAD16_SCHPO)~cDNA EST EMBL:Z14466 comes from this gene~cDNA EST yk636b12.5 comes from this gene~cDNA EST yk86a4.3 comes from this gene~cDNA EST yk131g2.3 comes from this gene~cDNA EST yk86a4.5 c> Length = 935 Score = 74.9 bits (181), Expect = 3e-12 Identities = 43/133 (32%), Positives = 70/133 (52%), Gaps = 18/133 (13%) Query: 521 DTEKEMEREEKEERKGEREGVKVVVDSRELRSEVVKRLKTLGVKIEVKTLDVGDYIISDE 580 D +M+ EE+ ER K++VD RE SE+ L T G + T+++GDYI+S Sbjct: 672 DPRDQMDPEEELERP------KIIVDMREFNSELPTVLYTKGYNVVATTIEIGDYILSPN 725 Query: 581 VAIERKSANDFIQSIIDGRLFDQVKRLKDSYPRPVVIVE------------GQLYGIRNV 628 +AIERK+ +D QS+ GR+F Q++++ + Y V+++E G G + Sbjct: 726 IAIERKALDDLTQSLQSGRVFKQIEQMLEHYDCTVLLIESNRKFETKIVNGGPFQGELSR 785 Query: 629 HPNAIRGAIASIV 641 H IR S++ Sbjct: 786 HCREIRSIFCSLI 798 >pir||T18568 hypothetical protein VF13D12L.2 - Caenorhabditis elegans Length = 401 Score = 74.9 bits (181), Expect = 3e-12 Identities = 43/133 (32%), Positives = 70/133 (52%), Gaps = 18/133 (13%) Query: 521 DTEKEMEREEKEERKGEREGVKVVVDSRELRSEVVKRLKTLGVKIEVKTLDVGDYIISDE 580 D +M+ EE+ ER K++VD RE SE+ L T G + T+++GDYI+S Sbjct: 138 DPRDQMDPEEELERP------KIIVDMREFNSELPTVLYTKGYNVVATTIEIGDYILSPN 191 Query: 581 VAIERKSANDFIQSIIDGRLFDQVKRLKDSYPRPVVIVE------------GQLYGIRNV 628 +AIERK+ +D QS+ GR+F Q++++ + Y V+++E G G + Sbjct: 192 IAIERKALDDLTQSLQSGRVFKQIEQMLEHYDCTVLLIESNRKFETKIVNGGPFQGELSR 251 Query: 629 HPNAIRGAIASIV 641 H IR S++ Sbjct: 252 HCREIRSIFCSLI 264 >dbj|BAB13422.1| (AB046816) KIAA1596 protein [Homo sapiens] Length = 1151 Score = 74.5 bits (180), Expect = 4e-12 Identities = 57/216 (26%), Positives = 107/216 (49%), Gaps = 10/216 (4%) Query: 537 EREGVKVVVDSRELRS--EVVKRLKTL-GVKIEVKTLDVGDYIISDEVAIERKSANDFIQ 593 E +G ++V E+ S EV+ L+ + G+++EV L+ DYI+S+ + +ER+S ++ + Sbjct: 917 EGKGTCILVGGHEITSGLEVISSLRAIHGLQVEVCPLNGCDYIVSNRMVVERRSQSEMLN 976 Query: 594 SIIDGRLFDQVKRLKDSYPRPVVIVEGQLYGI----RNVHPNAIRGAIASIVIDFGVPII 649 S+ + +Q++ L+ + R VIVE R ++ + +I G+ I+ Sbjct: 977 SVNKNKFIEQIQHLQSMFERICVIVEKDREKTGDTSRMFRRTKSYDSLLTTLIGAGIRIL 1036 Query: 650 FSSNPEETANYIFFMARREQEERRREVRVRGEKKALTLAERQRLIVESLPHVSATLAKRL 709 FSS EETA+ + ++ EQ R+ V + + S+P++S A + Sbjct: 1037 FSSCQEETADLLKELSLVEQ---RKNVGIHVPTVVNSNKSEALQFYLSIPNISYITALNM 1093 Query: 710 LKHFGSVERVFTASVPELMKVEGIGEKIAREIRRVI 745 F SV+R+ +S+ E+ + + A EI R I Sbjct: 1094 CHQFSSVKRMANSSLQEISMYAQVTHQKAEEIYRYI 1129 >dbj|BAA31233.1| (D89592) rhlE [Vibrio alginolyticus] Length = 411 Score = 71.8 bits (173), Expect = 3e-11 Identities = 48/192 (25%), Positives = 93/192 (48%), Gaps = 11/192 (5%) Query: 349 EVLKELVKEQLSKKENSKIIVFTNYRETARKVVEELTKEGIKAKRFVGQATKENDRGMSQ 408 ++ L+ L++ + S++++F + A K+V +L K GI A+ F G +Q Sbjct: 228 DMKSSLLSHMLNENDWSQVLIFIETKHGAAKLVSQLEKRGIVAEAF--------HSGRNQ 279 Query: 409 REQKLILDSFARGEFNVLVATSVGEEGLDVPEVDLVVFYEPVPSAIRSVQRRGRTGRQ-K 467 R ++ +++ F GE LVAT V G+D+ + +V+ Y+ A V R GRTGR Sbjct: 280 RVRQELIEKFKAGEIQYLVATGVAARGIDIDNLPVVINYDLPFPADEYVHRIGRTGRAGA 339 Query: 468 PGRVVILIAQGTRDEAYYWSSKHKERQMRETIRMVSQAIKREKQLSLESYVKKDTEKEME 527 G + L+++ D + + + E + + A ++ +S+ +YV K+ K + Sbjct: 340 QGEAISLVSKD--DFKNLCMIESRLGHLLERVEIEGFAPRKPVPISILNYVPKNKRKPQD 397 Query: 528 REEKEERKGERE 539 + E +R+ Sbjct: 398 NRPRRENSEQRD 409 >pir||B72707 hypothetical protein APE1073 - Aeropyrum pernix (strain K1) >gi|5104743|dbj|BAA80058.1| (AP000060) 539aa long hypothetical protein [Aeropyrum pernix] Length = 539 Score = 71.8 bits (173), Expect = 3e-11 Identities = 53/181 (29%), Positives = 91/181 (49%), Gaps = 27/181 (14%) Query: 305 KKLYEEAKTGSTRASKELFLDRRMKKALALLIQAKELGIDHPKMEVLKELVKEQLSKKEN 364 +K+ E+A+ G A + + ++ RMK+ + L K+ +++LV+E+LS+ Sbjct: 373 EKILEDARRGDPTAIEAIRVNTRMKEIVQL---------SESKIRAVEKLVREELSR--G 421 Query: 365 SKIIVFTNYRETARKVVEELTKEGIKAKRFVGQATKENDRGMSQREQKLILDSFARGEFN 424 SK+IVFT YR A ++ R G G+ +R ++ L F + Sbjct: 422 SKVIVFTQYRRQAEEIA-----------RRTGALLLHG--GLERRVREATLAKFRALKAG 468 Query: 425 VLVATSVGEEGLDVPEVDLVVFYEPVPSAIRSVQRRGRTGRQKPGRVVIL---IAQGTRD 481 LV T+VG+EGLD+P+ ++ + S + +QR GR R G+ +L IA+GT + Sbjct: 469 ALVVTTVGDEGLDIPDANVGILVSGTGSRRQFIQRLGRLLRPGEGKRAVLYEVIARGTGE 528 Query: 482 E 482 E Sbjct: 529 E 529 >sp|P42305|DEAD_BACSU COLD-SHOCK DEAD-BOX PROTEIN A HOMOLOG (ATP-DEPENDENT RNA HELICASE DEAD HOMOLOG) >gi|7446092|pir||E69613 ATP-dependent RNA helicase deaD - Bacillus subtilis >gi|665989|dbj|BAA11693.1| (D83026) homologous to ATP dependent RNA helicase DeaD of E. coli; hypothetical [Bacillus subtilis] >gi|2636457|emb|CAB15947.1| (Z99124) ATP-dependent RNA helicase [Bacillus subtilis] Length = 479 Score = 71.4 bits (172), Expect = 3e-11 Identities = 86/396 (21%), Positives = 166/396 (41%), Gaps = 46/396 (11%) Query: 234 KPLAEAGLIESASADLPKKEILRAGQIINEETAKGNHDLRK--LLLFHAMALKLHHAIEL 291 K + + +S D K E+ + I+ + + K L L L + A E+ Sbjct: 97 KRIKATAVFGKSSFDKQKAELKQKSHIVVGTPGRVLDHIEKGTLPLDRLSYLVIDEADEM 156 Query: 292 LETQGLSALRVYLKKLYEEAKTGSTRASKELFLDRRMKKALALL--IQAKELG-----ID 344 L + + +K L E T A+ +++ ++ + I+ K G I+ Sbjct: 157 LNMGFIEQVEAIIKHLPTERTTMLFSATLPQDIEKLSRQYMQNPEHIEVKAAGLTTRNIE 216 Query: 345 HPKMEVLKE----LVKEQLSKKENSKIIVFTNYRETARKVVEELTKEGIKAKRFVGQATK 400 H ++V +E L+K+ L + I+F +E ++ +EL G + G Sbjct: 217 HAVIQVREENKFSLLKDVLMTENPDSCIIFCRTKEHVNQLTDELDDLGYPCDKIHG---- 272 Query: 401 ENDRGMSQREQKLILDSFARGEFNVLVATSVGEEGLDVPEVDLVVFYEPVPSAIRSVQRR 460 GM Q ++ +++ F RGE+ LVAT V G+D+ + LV+ Y+ V R Sbjct: 273 ----GMIQEDRFDVMNEFKRGEYRYLVATDVAARGIDIENISLVINYDLPLEKESYVHRT 328 Query: 461 GRTGRQKPGRVVILIAQGTRDEAYYWSSKHKERQMRETIRMVSQAIKREKQLSLESYVKK 520 GRTGR G + +A + + ++R + + + I + + S E +K Sbjct: 329 GRTGR-----------AGNKGKAISFVTAFEKRFLADIEEYIGFEIPKIEAPSQEEVARK 377 Query: 521 DTEKEMEREEKEERKGEREGVKVVVDSRELRSEVVKRLKTLGVKIEVKTLD-VG-----D 574 E + ++ E K ++ S EL +++K G K +++ +D VG D Sbjct: 378 KPEFLAKLNDRPESKKDK--------SEELNKDIMKLYFNGGKKKKIRAVDFVGTIAKID 429 Query: 575 YIISDEVAIERKSANDFIQSIIDGRLFDQVKRLKDS 610 + +D++ I N I++G+ +K +K++ Sbjct: 430 GVSADDIGIITIMDNASYVEILNGKGPHVLKVMKNT 465 >gi|6325235 UV endonuclease; Rad1p [Saccharomyces cerevisiae] >gi|131810|sp|P06777|RAD1_YEAST DNA REPAIR PROTEIN RAD1 >gi|73262|pir||DDBYD1 RAD1 protein - yeast (Saccharomyces cerevisiae) >gi|172325|gb|AAA34934.1| (M15435) RAD1 protein [Saccharomyces cerevisiae] >gi|1039455|gb|AAB68165.1| (U36624) Rad1p [Saccharomyces cerevisiae] Length = 1100 Score = 70.2 bits (169), Expect = 7e-11 Identities = 74/345 (21%), Positives = 150/345 (43%), Gaps = 51/345 (14%) Query: 444 VVFYEPVPSAIRSVQRRGRTGRQKPGRVVILIAQGTRDEAYYWSSKHKERQ-----MRET 498 ++ +EP S IR ++ + +V + + +E + ++ +E+ +RE Sbjct: 712 IIMFEPDISFIRQIEVYKAIVKDLQPKVYFMYYGESIEEQSHLTAIKREKDAFTKLIREN 771 Query: 499 IRMVSQAIKREKQLSLESYVKKDTEKEMEREEKEERKGEREGVK------VVVDSRELRS 552 + E ++ ++ + R+ G ++G V+VD+RE + Sbjct: 772 ANLSHHFETNEDLSHYKNLAERKLKLSKLRKSNTRNAGGQQGFHNLTQDVVIVDTREFNA 831 Query: 553 EVVKRLKTLGVKIEVKTLDVGDYIISDEVAIERKSANDFIQSIIDGRLFDQVKRLKDSYP 612 + L G+++ L VGDY+I+ ++ +ERKS +D I S+ + RL +Q K++ Y Sbjct: 832 SLPGLLYRYGIRVIPCMLTVGDYVITPDICLERKSISDLIGSLQNNRLANQCKKMLKYYA 891 Query: 613 RPVVIV---EGQLYG--------------IRNVHP-------NAIRGAIASIVIDF-GVP 647 P +++ EGQ + I VHP + I+ +A +V+ F + Sbjct: 892 YPTLLIEFDEGQSFSLEPFSERRNYKNKDISTVHPISSKLSQDEIQLKLAKLVLRFPTLK 951 Query: 648 IIFSSNPEETANYIF-FMARREQEERRREV-------------RVRGEKKALTLAERQRL 693 II+SS+P +T N I REQ + V +G K ++ +RL Sbjct: 952 IIWSSSPLQTVNIILELKLGREQPDPSNAVILGTNKVRSDFNSTAKGLKDGDNESKFKRL 1011 Query: 694 I-VESLPHVSATLAKRLLKHFGSVERVFTASVPELMKVEGIGEKI 737 + V + + ++ +K F ++++ + EL+ E + ++I Sbjct: 1012 LNVPGVSKIDYFNLRKKIKSFNKLQKLSWNEINELINDEDLTDRI 1056 Database: ./suso.pep Posted date: Jul 6, 2001 5:57 PM Number of letters in database: 840,471 Number of sequences in database: 2977 Database: /banques/blast2/nr.pep Posted date: Dec 14, 2000 12:46 PM Number of letters in database: 188,266,275 Number of sequences in database: 595,510 Lambda K H 0.318 0.136 0.370 Gapped Lambda K H 0.270 0.0470 0.230 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 253501257 Number of Sequences: 2977 Number of extensions: 10571981 Number of successful extensions: 61815 Number of sequences better than 1.0e-10: 45 Number of HSP's better than 0.0 without gapping: 28 Number of HSP's successfully gapped in prelim test: 17 Number of HSP's that attempted gapping in prelim test: 61656 Number of HSP's gapped (non-prelim): 67 length of query: 752 length of database: 189,106,746 effective HSP length: 63 effective length of query: 689 effective length of database: 151,402,065 effective search space: 104316022785 effective search space used: 104316022785 T: 11 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.8 bits) X3: 64 (24.9 bits) S1: 41 (21.7 bits) S2: 168 (69.9 bits)