BLASTP 2.0.10 [Aug-26-1999]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= PAB0250 (PAB0250) DE:CYSTEINE SYNTHASE, O-ACETYLSERINE (THIOL)
LYASE B (THIOL).
(284 letters)
Database: ./suso.pep; /banques/blast2/nr.pep
598,487 sequences; 189,106,746 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
pir||A75152 cysteine synthase (EC 4.2.99.8) PAB0250 [similarity]... 559 e-158
gb|AAK40690.1| Cysteine synthase B (cysM) [Sulfolobus solfataricus] 238 4e-62
pir||E72537 probable cysteine synthase APE1586 - Aeropyrum perni... 166 4e-40
emb|CAC11675.1| (AL445064) cysteine synthase related protein [Th... 131 7e-30
sp|Q00834|CYSK_SPIOL CYSTEINE SYNTHASE (O-ACETYLSERINE SULFHYDRY... 127 1e-28
sp|Q9XEA8|CYK2_ORYSA CYSTEINE SYNTHASE (O-ACETYLSERINE SULFHYDRY... 127 1e-28
dbj|BAA22144.1| (AB006900) cysteine synthase type II [Entamoeba ... 127 1e-28
gb|AAB64031.1| (AC002333) cysteine synthase (cpACS1) [Arabidopsi... 127 1e-28
sp|P16703|CYSM_ECOLI CYSTEINE SYNTHASE B (O-ACETYLSERINE SULFHYD... 127 2e-28
pir||S49587 cysteine synthase (EC 4.2.99.8) cpACS1 - Arabidopsis... 127 2e-28
sp|P32260|CYSL_SPIOL CYSTEINE SYNTHASE, CHLOROPLAST PRECURSOR (O... 126 3e-28
dbj|BAA21916.1| (AB000266) cysteine synthase [Entamoeba histolyt... 126 3e-28
sp|P71128|CYSM_CAMJE CYSTEINE SYNTHASE B (O-ACETYLSERINE SULFHYD... 125 6e-28
emb|CAB71290.1| (AJ271727) O-acetylserine (thiol) lyase [Arabido... 125 6e-28
dbj|BAA88220.1| (AB028632) cysteine synthase 2 [Entamoeba dispar] 125 7e-28
sp|O67507|CYSM_AQUAE CYSTEINE SYNTHASE (O-ACETYLSERINE SULFHYDRY... 124 1e-27
emb|CAB71303.1| (AJ130879) o-acetylserine sulfhydrylase [Clostri... 124 1e-27
pir||S29733 cysteine synthase (EC 4.2.99.8) B precursor, chlorop... 123 3e-27
pir||D82312 cysteine synthase B VC0537 [imported] - Vibrio chole... 122 4e-27
sp|P31300|CYSL_CAPAN CYSTEINE SYNTHASE, CHLOROPLAST PRECURSOR (O... 122 4e-27
pir||JC6185 cysteine synthase (EC 4.2.99.8) B - Campylobacter je... 122 5e-27
pir||T47800 cysteine synthase - Arabidopsis thaliana >gi|7019670... 122 5e-27
gb|AAG01804.1|AF276772_3 (AF276772) O-acetylserine sulfhydrylase... 122 6e-27
pir||A83530 cysteine synthase B PA0932 [imported] - Pseudomonas ... 122 6e-27
sp|P29848|CYSM_SALTY CYSTEINE SYNTHASE B (O-ACETYLSERINE SULFHYD... 121 1e-26
sp|O81155|CYSL_SOLTU CYSTEINE SYNTHASE, CHLOROPLAST PRECURSOR (O... 120 2e-26
dbj|BAA93051.1| (AB040503) cysteine synthase [Allium tuberosum] 120 2e-26
emb|CAC09469.1| (AL442113) cysteine synthase [Oryza sativa] 120 2e-26
gi|6321594 Cystathionine beta-synthase; Cys4p [Saccharomyces cer... 119 3e-26
dbj|BAA03952.1| (D16502) cystathionine beta-synthase [Saccharomy... 119 3e-26
sp|P80608|CYSK_MAIZE CYSTEINE SYNTHASE (O-ACETYLSERINE SULFHYDRY... 119 3e-26
pir||T07962 probable cysteine synthase (EC 4.2.99.8) 1A precurso... 119 4e-26
dbj|BAB03807.1| (AP001507) cysteine synthase A [Bacillus halodur... 119 4e-26
emb|CAA71799.1| (Y10846) O-acetylserine(thiol) lyase [Brassica j... 118 6e-26
pir||F72349 cysteine synthase (EC 4.2.99.8) TM0665 [similarity] ... 118 6e-26
gb|AAG28533.1|AF198621_4 (AF198621) cysteine synthase [Bacillus ... 118 6e-26
sp|P95230|CYSK_MYCTU CYSTEINE SYNTHASE A (O-ACETYLSERINE SULFHYD... 118 7e-26
gb|AAD23910.1|AF073698_1 (AF073698) cysteine synthase [Oryza sat... 118 7e-26
dbj|BAA03947.1| (D16496) cystathionine beta-synthase [Saccharomy... 118 9e-26
sp|O34476|CYSM_BACSU PROBABLE CYSTEINE SYNTHASE (O-ACETYLSERINE ... 118 9e-26
sp|Q9XEA6|CYK1_ORYSA CYSTEINE SYNTHASE (O-ACETYLSERINE SULFHYDRY... 117 1e-25
pir||H81161 probable cysteine synthase (EC 4.2.99.8) NMA0974 [im... 117 1e-25
dbj|BAB06990.1| (AP001518) cysteine synthase [Bacillus halodurans] 117 1e-25
pir||T43792 cysteine synthase (EC 4.2.99.8) cysK [similarity] - ... 117 2e-25
sp|Q43317|CYSK_CITLA CYSTEINE SYNTHASE (O-ACETYLSERINE SULFHYDRY... 116 2e-25
sp|P38076|CYSK_WHEAT CYSTEINE SYNTHASE (O-ACETYLSERINE SULFHYDRY... 116 3e-25
sp|P47999|CYSL_ARATH CYSTEINE SYNTHASE, CHLOROPLAST PRECURSOR (O... 116 3e-25
dbj|BAA78562.1| (AB024284) cysteine synthase [Arabidopsis thalia... 115 5e-25
gb|AAD56995.1|AC009465_9 (AC009465) putative cysteine synthase; ... 115 5e-25
pir||T44614 cysteine synthase (EC 4.2.99.8) A [similarity] - Met... 115 5e-25
pir||S48695 cysteine synthase (EC 4.2.99.8) isoform 7-4 precurso... 115 8e-25
sp|O81154|CYSK_SOLTU CYSTEINE SYNTHASE (O-ACETYLSERINE SULFHYDRY... 114 1e-24
sp|O32978|CYSK_MYCLE CYSTEINE SYNTHASE A (O-ACETYLSERINE SULFHYD... 114 1e-24
dbj|BAA88219.1| (AB028631) cysteine synthase 1 [Entamoeba dispar] 114 1e-24
gb|AAC37401.1| (L14578) cystathionine beta-synthase [Saccharomyc... 112 4e-24
sp|P37887|CYSK_BACSU CYSTEINE SYNTHASE (O-ACETYLSERINE SULFHYDRY... 112 5e-24
sp|O23735|CYK2_BRAJU CYSTEINE SYNTHASE (O-ACETYLSERINE SULFHYDRY... 112 5e-24
sp|Q9ZMW6|CYSM_HELPJ CYSTEINE SYNTHASE (O-ACETYLSERINE SULFHYDRY... 111 7e-24
dbj|BAA78561.1| (AB024283) cysteine synthase [Arabidopsis thaliana] 111 9e-24
sp|O23733|CYK1_BRAJU CYSTEINE SYNTHASE (O-ACETYLSERINE SULFHYDRY... 111 1e-23
pir||A71412 cysteine synthase (EC 4.2.99.8) 3A, cytosolic - Arab... 111 1e-23
pir||S65533 cysteine synthase (EC 4.2.99.8) 3A - Arabidopsis tha... 110 2e-23
sp|Q43725|CYSM_ARATH CYSTEINE SYNTHASE, MITOCHONDRIAL PRECURSOR ... 109 3e-23
pir||S49586 cysteine synthase (EC 4.2.99.8) ACS1 - Arabidopsis t... 109 5e-23
sp|O22682|CYSN_ARATH PROBABLE CYSTEINE SYNTHASE, CHLOROPLAST PRE... 108 6e-23
emb|CAC12819.1| (AJ299249) cysteine synthase [Nicotiana tabacum] 108 6e-23
pir||H69973 cysteine synthase (EC 4.2.99.8) yrhA [similarity] - ... 107 2e-22
gb|AAD56585.2|AF186381_1 (AF186381) cysteine synthase [Bacillus ... 107 2e-22
pir||A55450 cysteine synthase (EC 4.2.99.8) C precursor, mitocho... 105 5e-22
emb|CAA06819.1| (AJ006024) cysteine synthase, O-acetyl-L-serine ... 105 5e-22
sp|P47998|CYSK_ARATH CYSTEINE SYNTHASE (O-ACETYLSERINE SULFHYDRY... 104 9e-22
sp|P56067|CYSM_HELPY CYSTEINE SYNTHASE (O-ACETYLSERINE SULFHYDRY... 104 9e-22
pir||T09000 cysteine synthase (EC 4.2.99.8) - spinach chloroplas... 104 2e-21
gb|AAD23908.1|AF073696_1 (AF073696) cysteine synthase [Oryza sat... 103 2e-21
pir||F72594 cystathionine beta-synthase (EC 4.2.1.22) APE1223 [s... 102 4e-21
sp|P46794|CBS_DICDI CYSTATHIONINE BETA-SYNTHASE (SERINE SULFHYDR... 102 4e-21
gb|AAG19647.1| (AE005053) cysteine synthase; CysK [Halobacterium... 102 4e-21
pir||A75477 cysteine synthase (EC 4.2.99.8) DR0789 [similarity] ... 102 6e-21
dbj|BAB18760.1| (AB027000) beta-cyanoalanine synthase [Solanum t... 101 8e-21
emb|CAB89449.1| (AL354048) putative cystathionine beta-synthase ... 101 1e-20
pir||S77347 cysteine synthase (EC 4.2.99.8) - Synechocystis sp. ... 101 1e-20
dbj|BAA85110.1| (AB031003) O-acetylserine (thiol) lyase 1 [Cyani... 101 1e-20
sp|P73410|CYSK_SYNY3 CYSTEINE SYNTHASE (O-ACETYLSERINE SULFHYDRY... 101 1e-20
gb|AAG01002.1|AF287914_1 (AF287914) O-acetylserine lyase [Seleno... 101 1e-20
pir||T23591 cysteine synthase (EC 4.2.99.8) K10H10.2 [similarity... 100 2e-20
sp|P11096|CYSK_ECOLI CYSTEINE SYNTHASE A (O-ACETYLSERINE SULFHYD... 100 2e-20
dbj|BAA16288.1| (D90871) CYSTEINE SYNTHASE A (EC 4.2.99.8) (O-AC... 100 2e-20
pir||S74512 cystathionine beta-synthase (EC 4.2.1.22) cysM [simi... 99 5e-20
pir||T36133 cysteine synthase (EC 4.2.99.8) SCE19A.10c [similari... 99 7e-20
pir||T47233 cysteine synthase (EC 4.2.99.8) cysK - Lactococcus l... 99 7e-20
gb|AAB52276.1| (U97004) contains similarity to Pfam domain PF002... 98 9e-20
gi|4557415 cystathionine-beta-synthase; human cystathionine-beta... 98 1e-19
gb|AAC64684.1| (AF042836) cystathionine beta-synthase minor isof... 98 1e-19
emb|CAA61252.1| (X88562) cystathionine beta-synthase [Homo sapiens] 98 1e-19
pir||T47936 cysteine synthase (EC 4.2.99.8) cysC1 [similarity] -... 98 2e-19
gb|AAF64226.1|AF248039_1 (AF248039) cystathionine beta-synthase ... 98 2e-19
gi|6978611 cystathionine beta synthase [Rattus norvegicus] >gi|1... 97 2e-19
sp|P32232|CBS_RAT CYSTATHIONINE BETA-SYNTHASE (SERINE SULFHYDRAS... 97 2e-19
gb|AAA42024.1| (M88346) cystathionine beta-synthase [Rattus norv... 97 2e-19
pir||B42790 cystathionine beta-synthase (EC 4.2.1.22), splice fo... 97 2e-19
pir||C42790 cystathionine beta-synthase (EC 4.2.1.22), splice fo... 97 2e-19
sp|Q10624|CYSM_MYCTU CYSTEINE SYNTHASE B (O-ACETYLSERINE SULFHYD... 96 3e-19
gb|AAF50862.1| (AE003569) CG1753 gene product [alt 1] [Drosophil... 96 3e-19
gb|AAA23654.1| (M21451) cysK protein [Escherichia coli] 96 5e-19
emb|CAB70691.1| (AL137314) hypothetical protein [Homo sapiens] 96 6e-19
gb|AAD13393.1| (AF090120) cystathionine beta-synthetase; CBS [Ta... 94 1e-18
pdb|1FCJ|A Chain A, Crystal Structure Of Oass Complexed With Chl... 94 1e-18
pir||C82258 cysteine synthase A VC0968 [imported] - Vibrio chole... 94 2e-18
pdb|1D6S|A Chain A, Crystal Structure Of The K41a Mutant Of O-Ac... 92 7e-18
sp|P55708|Y4XP_RHISN PUTATIVE CYSTEINE SYNTHASE (O-ACETYLSERINE ... 92 9e-18
gb|AAD53158.1|AF176824_1 (AF176824) O-acetylserine(thiol)-lyase ... 91 1e-17
sp|P87131|CYSK_SCHPO PUTATIVE CYSTEINE SYNTHASE (O-ACETYLSERINE ... 90 2e-17
gb|AAF35961.1| (AC024136) contains similarity to SW:CBS_RAT [Cae... 90 2e-17
sp|P12674|CYSK_SALTY CYSTEINE SYNTHASE A (O-ACETYLSERINE SULFHYD... 90 3e-17
pir||T19367 cysteine synthase (EC 4.2.99.8) C17G1.7 [similarity]... 90 3e-17
dbj|BAA88310.1| (AB028865) O-acetylserine lyase [Streptococcus s... 90 3e-17
pir||E83306 cysteine synthase A PA2709 [imported] - Pseudomonas ... 90 3e-17
gb|AAB65342.1| (AF016425) Contains similarity to Pfam domain: PF... 89 6e-17
gb|AAF37822.1|AF192489_1 (AF192489) cysteine sulfhydrylase [Salm... 87 2e-16
emb|CAA88980.2| (Z49131) contains similarity to Pfam domain: PF0... 86 4e-16
pir||T27526 hypothetical protein ZC373.1 - Caenorhabditis elegan... 86 4e-16
sp|Q59966|SRPG_SYNP7 CYSTEINE SYNTHASE, PLASMID (O-ACETYLSERINE ... 86 5e-16
pir||C70894 probable cystathionine beta-synthase (EC 4.2.1.22) c... 85 7e-16
sp|Q44004|CYSM_ALCEU CYSTEINE SYNTHASE (O-ACETYLSERINE SULFHYDRY... 85 9e-16
dbj|BAA85111.1| (AB031004) O-acetylserine (thiol) lyase 2 [Cyani... 83 3e-15
gi|6321449 Ygr012wp [Saccharomyces cerevisiae] >gi|1706273|sp|P5... 81 1e-14
pir||D82758 cysteine synthase XF0831 [imported] - Xylella fastid... 81 1e-14
pir||G83381 probable cysteine synthase PA2104 [imported] - Pseud... 77 3e-13
emb|CAB55622.1| (AJ011044) cysteine synthase [Arabidopsis thaliana] 76 6e-13
pir||E83595 cystathionine beta-synthase PA0399 [imported] - Pseu... 70 3e-11
>pir||A75152 cysteine synthase (EC 4.2.99.8) PAB0250 [similarity] - Pyrococcus
abyssi (strain Orsay) >gi|5457806|emb|CAB49296.1|
(AJ248284) CYSTEINE SYNTHASE, O-ACETYLSERINE (THIOL)
LYASE B (THIOL). [Pyrococcus abyssi]
Length = 284
Score = 559 bits (1426), Expect = e-158
Identities = 284/284 (100%), Positives = 284/284 (100%)
Query: 1 MSFAKLEFFNPFSRSIKDRAVYNMLIKALRSGEIDGTNVLYEATSGNVGISIAALSAVFG 60
MSFAKLEFFNPFSRSIKDRAVYNMLIKALRSGEIDGTNVLYEATSGNVGISIAALSAVFG
Sbjct: 1 MSFAKLEFFNPFSRSIKDRAVYNMLIKALRSGEIDGTNVLYEATSGNVGISIAALSAVFG 60
Query: 61 LKFRAYIPKPTPKTTELLIKVFGAEVVRTNFDTIDKKFVEFVKLEARRDKALNLNQFEND 120
LKFRAYIPKPTPKTTELLIKVFGAEVVRTNFDTIDKKFVEFVKLEARRDKALNLNQFEND
Sbjct: 61 LKFRAYIPKPTPKTTELLIKVFGAEVVRTNFDTIDKKFVEFVKLEARRDKALNLNQFEND 120
Query: 121 ANFEAHYYGTARELEEQLRSIDKIPEIIIAGIGTSGHIAGISKYFKERYETKIIGVVPAK 180
ANFEAHYYGTARELEEQLRSIDKIPEIIIAGIGTSGHIAGISKYFKERYETKIIGVVPAK
Sbjct: 121 ANFEAHYYGTARELEEQLRSIDKIPEIIIAGIGTSGHIAGISKYFKERYETKIIGVVPAK 180
Query: 181 GETIPGIKRLETRPKWFFKVEVDEVVEVTAREAFEGILKVARSDGLLIGMSSGAVVKAYE 240
GETIPGIKRLETRPKWFFKVEVDEVVEVTAREAFEGILKVARSDGLLIGMSSGAVVKAYE
Sbjct: 181 GETIPGIKRLETRPKWFFKVEVDEVVEVTAREAFEGILKVARSDGLLIGMSSGAVVKAYE 240
Query: 241 KVRPEGTTVLIFPDDGFKYGEIFEMLLGEAQGKISSRTSQLQGS 284
KVRPEGTTVLIFPDDGFKYGEIFEMLLGEAQGKISSRTSQLQGS
Sbjct: 241 KVRPEGTTVLIFPDDGFKYGEIFEMLLGEAQGKISSRTSQLQGS 284
>gb|AAK40690.1| Cysteine synthase B (cysM) [Sulfolobus solfataricus]
Length = 297
Score = 238 bits (602), Expect = 4e-62
Identities = 129/271 (47%), Positives = 176/271 (64%), Gaps = 9/271 (3%)
Query: 2 SFAKLEFFNPFSRSIKDRAVYNMLIKALRSGEIDGTNVLYEATSGNVGISIAALSAVFGL 61
++AKLEF+NPFSRS+KDR + + +AL + + EATSGN GI++A+LS++FG+
Sbjct: 32 TWAKLEFYNPFSRSVKDRTAWFLFRQAL----LKNATHIVEATSGNTGIALASLSSIFGM 87
Query: 62 KFRAYIPKPTPKTTELLIKVFGAEVVRTNFDTIDKKFVEFVKLEARRDKALNLNQFENDA 121
+F ++P PK ++ +K+ G V+ T D + VK A ALNL+QF N
Sbjct: 88 RFTMFLPVVAPKVYKVFVKLLGGNVIEAGNSTND--VIPLVKKFAEMTNALNLDQFNNPI 145
Query: 122 NFEAHYYGTARELEEQLRSIDKIPEIIIAGIGTSGHIAGISKYFKERY--ETKIIGVVPA 179
N AHY TARE++EQL SI K P IIA +GT GHIAGI+KYFKE+Y + +IIGV P+
Sbjct: 146 NVIAHYETTAREIDEQLSSIGKKPSRIIATMGTGGHIAGIAKYFKEKYGNDVEIIGVQPS 205
Query: 180 KGETIPGIKRLETRPKWFFKVEVDEVVEVTAREAFEGILKVARSDGLLIGMSSGAVVKAY 239
+ IPGIKR V++D VV+V+ EA +G + VAR+ G+LIG+S+GA V AY
Sbjct: 206 ENSRIPGIKRQNGSNSLLRDVKIDRVVDVSLEEAIDGTISVARTSGILIGISAGATVAAY 265
Query: 240 EKVRP-EGTTVLIFPDDGFKYGEIFEMLLGE 269
+K+ TTVLIFPDD FKY +I E L E
Sbjct: 266 KKISDVSSTTVLIFPDDAFKYVDILEQTLKE 296
>pir||E72537 probable cysteine synthase APE1586 - Aeropyrum pernix (strain K1)
>gi|5105273|dbj|BAA80586.1| (AP000062) 389aa long
hypothetical cysteine synthase [Aeropyrum pernix]
Length = 389
Score = 166 bits (415), Expect = 4e-40
Identities = 95/262 (36%), Positives = 156/262 (59%), Gaps = 9/262 (3%)
Query: 5 KLEFFNPFSRSIKDRAVYNMLIKALRSGEIDGTNVLYEATSGNVGISIAALSAVFGLKFR 64
KLE++NPFS S+KDR ++ + R ++ +++ +ATS N G++++A++ ++G + R
Sbjct: 115 KLEWYNPFSLSVKDRPAVEIISRLSR--RVEKGSLVADATSSNFGVALSAVARLYGYRAR 172
Query: 65 AYIPKPTPKTTELLIKVFGAEVVRTNFDTIDKKFVEFVKLEARRDKALNLNQFENDANFE 124
Y+P + +LL ++ GA+V+ + V +++ + +++NQF NDANFE
Sbjct: 173 VYLPGAAEEFGKLLPRLLGAQVIVDPEAPSTVHLLPRVMKDSKNEGFVHVNQFYNDANFE 232
Query: 125 AHYYGTARELEEQLRSIDKIPEIIIAGIGTSGHIAGISKYFKERYET-KIIGVVPAKGET 183
AH GTARE+ Q R + +GTSGH++ + Y + + + + V PA+G++
Sbjct: 233 AHMRGTAREIFVQSRRGGLALRGVAGSLGTSGHMSAAAFYLQSVDPSIRAVLVQPAQGDS 292
Query: 184 IPGIKRLETRPKWFFKVEVD-EVVEVTAREAFEGILKVARSDGLLIGMSSGAVVKAYEKV 242
IPGI+R+ET W +++ + EVT EA E +++VARSDGL+IG S GA VKA K
Sbjct: 293 IPGIRRVETGMLWINMLDISYTLAEVTLEEAMEAVVEVARSDGLVIGPSGGAAVKALAKK 352
Query: 243 RPEGTT-----VLIFPDDGFKY 259
EG V++ PD GFKY
Sbjct: 353 AAEGDLEPGDYVVVVPDTGFKY 374
>emb|CAC11675.1| (AL445064) cysteine synthase related protein [Thermoplasma
acidophilum]
Length = 299
Score = 131 bits (327), Expect = 7e-30
Identities = 90/269 (33%), Positives = 145/269 (53%), Gaps = 20/269 (7%)
Query: 3 FAKLEFFNPFSRSIKDRAVYNMLIKALRSGEIDGTNVLYEATSGNVGISIAALSAVFGLK 62
+AK+E+ N F SIKDR + ++ SG++DG L EA+SGN G++++ ++ + G++
Sbjct: 35 YAKIEWMNRFG-SIKDRPAFFIIYSLKESGDLDG-KTLIEASSGNTGLAVSGIAKMLGVR 92
Query: 63 FRAYIPKPTPKTTELLIKVFGAEVVRTNFDTIDKKFVEFVKLEARRDKALNLNQFENDAN 122
+P+ T+ I G+ V+ T + + +K D + LNQ N N
Sbjct: 93 SIIVLPENASPFTKRSIMENGSRVIETPASLGTEGSINRLKEMVSTDDFIWLNQHSNTKN 152
Query: 123 FEAHYYGTARELEEQLRSIDKIPEIIIAGIGTSGHIAGISKYFKE-RYETKIIGVVPAKG 181
++HYY TARE+ + + +P I+AGIGT G I GI++YFKE ++IGV PA G
Sbjct: 153 SDSHYYTTAREMVDSM----GVPSAIVAGIGTGGTITGIARYFKEIDPGVRVIGVQPAAG 208
Query: 182 ETIPGIKRLETRPKWFFKVE-----VDEVVEVTAREAFEGILKVARSDGLLIGMSSGAVV 236
I G++ + + K+ ++ +DE+V V +A I + G LIG+S+GA +
Sbjct: 209 SHIHGLRNV-SASKYRGIIDRYGHLIDEIVYVNEDQAISEIRRYYEKSGQLIGISAGANL 267
Query: 237 KA----YEKVRPEGTTVLIFPDDGFKYGE 261
A +E+ R T +FPD G KY E
Sbjct: 268 YASRLFHERYRKIFT---VFPDSGEKYRE 293
>sp|Q00834|CYSK_SPIOL CYSTEINE SYNTHASE (O-ACETYLSERINE SULFHYDRYLASE) (O-ACETYLSERINE
(THIOL)-LYASE) (CSASE A) (OAS-TL A)
>gi|421796|pir||S35094 cysteine synthase (EC 4.2.99.8) A
- spinach >gi|218277|dbj|BAA01279.1| (D10476)
O-acetylserine(thiol) lyase [Spinacia oleracea]
Length = 325
Score = 127 bits (317), Expect = 1e-28
Identities = 104/292 (35%), Positives = 153/292 (51%), Gaps = 27/292 (9%)
Query: 4 AKLEFFNPFSRSIKDRAVYNMLIKALRSGEID-GTNVLYEATSGNVGISIAALSAVFGLK 62
AKLE P S S+KDR ++M+ A +SG I G +VL E TSGN GI +A ++A G K
Sbjct: 37 AKLEGMEPCS-SVKDRIGFSMITDAEKSGLITPGESVLIEPTSGNTGIGLAFIAAAKGYK 95
Query: 63 FRAYIPKPTPKTTELLIKVFGAEVVRTNFDTIDKKFVEFVKLEARRDKALN---LNQFEN 119
+P +++ FGAE++ T+ K V+ K E RDK N L QFEN
Sbjct: 96 LIITMPASMSLERRTILRAFGAELILTDPAKGMKGAVQ--KAEEIRDKTPNSYILQQFEN 153
Query: 120 DANFEAHYYGTARELEEQLRSIDKIPEIIIAGIGTSGHIAGISKYFKERY-ETKIIGVVP 178
AN + HY T E+ + KI +I ++GIGT G I G KY KE+ + K+IG+ P
Sbjct: 154 PANPKVHYETTGPEIWKGTGG--KI-DIFVSGIGTGGTITGAGKYLKEQNPDVKLIGLEP 210
Query: 179 AKGETI----PGIKRLETRPKWFFKVE-----VDEVVEVTAREAFEGILKVARSDGLLIG 229
+ + PG +++ F +DEVV++++ E+ E +A +GLL+G
Sbjct: 211 VESAVLSGGKPGPHKIQGLGAGFIPGVLDVNIIDEVVQISSEESIEMAKLLALKEGLLVG 270
Query: 230 MSSGAVVKAYEKV--RPEGT---TVLIFPDDGFKY--GEIFEMLLGEAQGKI 274
+SSGA A KV RPE V +FP G +Y +F+ + EA+ +
Sbjct: 271 ISSGAAAAAAIKVAKRPENAGKLIVAVFPSFGERYLSSVLFDSVRKEAESMV 322
>sp|Q9XEA8|CYK2_ORYSA CYSTEINE SYNTHASE (O-ACETYLSERINE SULFHYDRYLASE) (O-ACETYLSERINE
(THIOL)-LYASE) (CSASE) (OAS-TL)
>gi|4574139|gb|AAD23909.1|AF073697_1 (AF073697) cysteine
synthase [Oryza sativa]
Length = 325
Score = 127 bits (317), Expect = 1e-28
Identities = 102/290 (35%), Positives = 153/290 (52%), Gaps = 23/290 (7%)
Query: 4 AKLEFFNPFSRSIKDRAVYNMLIKALRSGEID-GTNVLYEATSGNVGISIAALSAVFGLK 62
AKLE P S S+KDR Y+M+ A G I G +VL E TSGN GI +A ++A G K
Sbjct: 37 AKLEIMEPCS-SVKDRIGYSMITDAEEKGLITPGKSVLIEPTSGNTGIGLAFMAAAKGYK 95
Query: 63 FRAYIPKPTPKTTELLIKVFGAEVVRTNFDTIDKKFVEFV-KLEARRDKALNLNQFENDA 121
+P +++K FGAE+V T+ K ++ +L A+ + L QFEN A
Sbjct: 96 LILTMPASMSMERRIILKAFGAELVLTDPLLGMKGAIQKADELAAKMPNSYILQQFENPA 155
Query: 122 NFEAHYYGTARELEEQLRSIDKIPEIIIAGIGTSGHIAGISKYFKERY-ETKIIGVVPAK 180
N + HY T E+ + + K+ +I+++GIGT G + G KY KE+ E KI GV P +
Sbjct: 156 NPKIHYETTGPEIWK--ATAGKV-DILVSGIGTGGTVTGTGKYLKEQNPEIKIYGVEPTE 212
Query: 181 GETI----PGIKRLETRPKWFFKVE-----VDEVVEVTAREAFEGILKVARSDGLLIGMS 231
+ PG +++ F +DEVV+V++ EA ++A +GLL+G+S
Sbjct: 213 SAILSGGRPGPHKIQGIGAGFVPGVLDVNLLDEVVQVSSDEAISMAKQLALKEGLLVGIS 272
Query: 232 SGAVVKAYEKV--RPEG---TTVLIFPDDGFKY--GEIFEMLLGEAQGKI 274
SGA A +V RPE V++FP G +Y +FE + EA+ +
Sbjct: 273 SGAAAVAAIRVAQRPENKGKLVVVVFPSFGERYLSSVLFESIKREAENMV 322
>dbj|BAA22144.1| (AB006900) cysteine synthase type II [Entamoeba histolytica]
Length = 337
Score = 127 bits (316), Expect = 1e-28
Identities = 89/272 (32%), Positives = 142/272 (51%), Gaps = 22/272 (8%)
Query: 5 KLEFFNPFSRSIKDRAVYNMLIKALRSGEIDGTNVLYEATSGNVGISIAALSAVFGLKFR 64
KLE+FNP S S+KDR +N++ +A++ G + + EATSGN GI++ AVFG +
Sbjct: 47 KLEYFNPMS-SVKDRVGFNIVYQAIKDGRLKPGMEIIEATSGNTGIALCQAGAVFGYRVN 105
Query: 65 AYIPKPTPKTTELLIKVFGAEVVRTNFDTIDKKFVEFVK--LEARRDKALNLNQFENDAN 122
+P ++++K FGAE++ T +E V ++ K NQF N N
Sbjct: 106 IAMPSTMSVERQMIMKAFGAELILTEGKKGMPGAIEEVNKMIKENPGKYFVANQFGNPDN 165
Query: 123 FEAHYYGTARELEEQLRSIDKIPEIIIAGIGTSGHIAGISKYFKERYE-TKIIGVVPAKG 181
AH+Y TA E+ E D +I+++ +GTSG + G+++ KE+ + KII V P +
Sbjct: 166 TAAHHY-TANEIWE---DTDGEVDIVVSAVGTSGTVIGVAEKLKEKKKGIKIIAVEPEES 221
Query: 182 ETIPGIKR---------LETRPKWFFKVEVDEVVEVTAREAFEGILKVARSDGLLIGMSS 232
+ G + P + K VDE++ + ++A++ V + DG++ GMSS
Sbjct: 222 AVLEGKAKGPHGIQGIGAGFIPDIYKKEFVDEIIPIKTQDAWKMARAVVKYDGIMCGMSS 281
Query: 233 GAVV----KAYEKVRPEG-TTVLIFPDDGFKY 259
GA + K EK EG T V+I P G +Y
Sbjct: 282 GAAILAGLKEAEKPENEGKTIVIIVPSCGERY 313
>gb|AAB64031.1| (AC002333) cysteine synthase (cpACS1) [Arabidopsis thaliana]
>gi|6899950|emb|CAB71292.1| (AJ271728) O-acetylserine
(thiol) lyase B [Arabidopsis thaliana]
>gi|6983576|emb|CAA56594.2| (X80377) O-acetylserine
(thiol) lyase [Arabidopsis thaliana]
Length = 392
Score = 127 bits (316), Expect = 1e-28
Identities = 103/290 (35%), Positives = 151/290 (51%), Gaps = 29/290 (10%)
Query: 4 AKLEFFNPFSRSIKDRAVYNMLIKALRSGEID-GTNVLYEATSGNVGISIAALSAVFGLK 62
AKLE P S+KDR Y+M+ A G I G +VL E+TSGN GI +A ++A G K
Sbjct: 104 AKLEIMEPCC-SVKDRIGYSMITDAEEKGLITPGKSVLVESTSGNTGIGLAFIAASKGYK 162
Query: 63 FRAYIPKPTPKTTELLIKVFGAEVVRT----NFDTIDKKFVEFVKLEARRDKALNLNQFE 118
+P +L++ FGAE+V T +K E +K + + L QF+
Sbjct: 163 LILTMPASMSLERRVLLRAFGAELVLTEPAKGMTGAIQKAEEILK---KTPNSYMLQQFD 219
Query: 119 NDANFEAHYYGTARELEEQLRSIDKIPEIIIAGIGTSGHIAGISKYFKERY-ETKIIGVV 177
N AN + HY T E+ E R KI +I++AGIGT G I G+ ++ KER E K+IGV
Sbjct: 220 NPANPKIHYETTGPEIWEDTRG--KI-DILVAGIGTGGTITGVGRFIKERKPELKVIGVE 276
Query: 178 PAKGETI----PGIKRLE-----TRPKWFFKVEVDEVVEVTAREAFEGILKVARSDGLLI 228
P + + PG +++ PK VDE + +++ EA E ++A +GLL+
Sbjct: 277 PTESAILSGGKPGPHKIQGIGAGFVPKNLDLAIVDEYIAISSEEAIETSKQLALQEGLLV 336
Query: 229 GMSSGAVVKAYEKV--RPEGTTVLI---FPDDGFKY--GEIFEMLLGEAQ 271
G+SSGA A +V RPE LI FP G +Y ++F+ + E +
Sbjct: 337 GISSGAAAAAAIQVAKRPENAGKLIAVVFPSFGERYLSTQLFQSIREECE 386
>sp|P16703|CYSM_ECOLI CYSTEINE SYNTHASE B (O-ACETYLSERINE SULFHYDRYLASE B)
(O-ACETYLSERINE (THIOL)-LYASE B) (CSASE B)
>gi|68324|pir||SYECBC cysteine synthase (EC 4.2.99.8) B
- Escherichia coli >gi|145662|gb|AAA23640.1| (M32101)
o-acetylserine (thiol)-lyase-B [Escherichia coli]
>gi|1799840|dbj|BAA16295.1| (D90871) cysteine synthase
(EC 4.2.99.8) B [Escherichia coli]
>gi|1799850|dbj|BAA16304.1| (D90872) cysteine synthase
(EC 4.2.99.8) B [Escherichia coli]
>gi|2367138|gb|AAC75474.1| (AE000329) cysteine synthase
B, O-acetylserine sulfhydrolase B [Escherichia coli K12]
Length = 303
Score = 127 bits (315), Expect = 2e-28
Identities = 85/261 (32%), Positives = 142/261 (53%), Gaps = 10/261 (3%)
Query: 5 KLEFFNPFSRSIKDRAVYNMLIKALRSGEIDGTNVLYEATSGNVGISIAALSAVFGLKFR 64
KLE NP + S+KDRA +M+++A + GEI +VL EATSGN GI++A ++A+ G + +
Sbjct: 30 KLEGNNP-AGSVKDRAALSMIVEAEKRGEIKPGDVLIEATSGNTGIALAMIAALKGYRMK 88
Query: 65 AYIPKPTPKTTELLIKVFGAEVVRTNFDTIDKKFVEFVKLEARRDKALNLNQFENDANFE 124
+P + ++ +GAE++ + + + A R + L+QF N N
Sbjct: 89 LLMPDNMSQERRAAMRAYGAELILVTKEQGMEGARDLALEMANRGEGKLLDQFNNPDNPY 148
Query: 125 AHYYGTARELEEQLRSIDKIPEIIIAGIGTSGHIAGISKYFKERYE-TKIIGVVPAKGET 183
AHY T E+ +Q +I ++ +GT+G I G+S++ +E+ + I+G+ P +G +
Sbjct: 149 AHYTTTGPEIWQQTGG--RITH-FVSSMGTTGTITGVSRFMREQSKPVTIVGLQPEEGSS 205
Query: 184 IPGIKRLETR--PKWFFKVEVDEVVEVTAREAFEGILKVARSDGLLIGMSSGAVVKA--- 238
IPGI+R T P F VDEV+++ R+A + ++A +G+ G+SSG V
Sbjct: 206 IPGIRRWPTEYLPGIFNASLVDEVLDIHQRDAENTMRELAVREGIFCGVSSGGAVAGALR 265
Query: 239 YEKVRPEGTTVLIFPDDGFKY 259
K P+ V I D G +Y
Sbjct: 266 VAKANPDAVVVAIICDRGDRY 286
>pir||S49587 cysteine synthase (EC 4.2.99.8) cpACS1 - Arabidopsis thaliana
>gi|572517|emb|CAA57344.1| (X81698) cysteine synthase
[Arabidopsis thaliana]
Length = 392
Score = 127 bits (315), Expect = 2e-28
Identities = 103/290 (35%), Positives = 149/290 (50%), Gaps = 29/290 (10%)
Query: 4 AKLEFFNPFSRSIKDRAVYNMLIKALRSGEID-GTNVLYEATSGNVGISIAALSAVFGLK 62
AKLE P S+KDR Y+M+ A G I G +VL E+TSGN GI +A ++A G K
Sbjct: 104 AKLEIMEPCC-SVKDRIGYSMITDAEEKGLITPGKSVLVESTSGNTGIGLAFIAASKGYK 162
Query: 63 FRAYIPKPTPKTTELLIKVFGAEVVRT----NFDTIDKKFVEFVKLEARRDKALNLNQFE 118
+P +L++ FGAE+V T +K E +K + + L QF+
Sbjct: 163 LILTMPASMSLERRVLLRAFGAELVLTEPAKGMTGAIQKAEEILK---KTPNSYMLQQFD 219
Query: 119 NDANFEAHYYGTARELEEQLRSIDKIPEIIIAGIGTSGHIAGISKYFKERY-ETKIIGVV 177
N AN + HY T E+ E R KI +I++AGIGT G I G+ ++ KER E K+IGV
Sbjct: 220 NPANPKIHYETTNPEIWEDTRG--KI-DILVAGIGTGGTITGVGRFIKERKPELKVIGVE 276
Query: 178 PAKGETIPGIKRLETR---------PKWFFKVEVDEVVEVTAREAFEGILKVARSDGLLI 228
P + + G K + PK VDE + +++ EA E ++A +GLL+
Sbjct: 277 PTESAILSGGKTGPHKIQGIGAGFVPKNLDLAIVDEYIAISSEEAIETSKQLALQEGLLV 336
Query: 229 GMSSGAVVKAYEKV--RPEGTTVLI---FPDDGFKY--GEIFEMLLGEAQ 271
G+SSGA A +V RPE LI FP G +Y ++F+ + E +
Sbjct: 337 GISSGAAAAAAIQVAKRPENAGKLIAVVFPSFGERYLSTQLFQSIREECE 386
>sp|P32260|CYSL_SPIOL CYSTEINE SYNTHASE, CHLOROPLAST PRECURSOR (O-ACETYLSERINE
SULFHYDRYLASE) (O-ACETYLSERINE (THIOL)-LYASE) (CSASE)
>gi|303902|dbj|BAA03542.1| (D14722) cysteine synthase
[Spinacia oleracea]
Length = 383
Score = 126 bits (313), Expect = 3e-28
Identities = 96/273 (35%), Positives = 143/273 (52%), Gaps = 21/273 (7%)
Query: 4 AKLEFFNPFSRSIKDRAVYNMLIKALRSGEID-GTNVLYEATSGNVGISIAALSAVFGLK 62
AKLE P S+KDR Y+M+ A + G I G L E TSGN GI +A ++A G K
Sbjct: 96 AKLESMEPCC-SVKDRIGYSMIDDAEQKGVITPGKTTLVEPTSGNTGIGLAFIAAARGYK 154
Query: 63 FRAYIPKPTPKTTELLIKVFGAEVVRTNFDTIDKKFVEFV-KLEARRDKALNLNQFENDA 121
+P +++K FGAE+V T+ K VE ++ + + L QF+N A
Sbjct: 155 ITLTMPASMSMERRVILKAFGAELVLTDPAKGMKGAVEKAEEILKKTPDSYMLQQFDNPA 214
Query: 122 NFEAHYYGTARELEEQLRSIDKIPEIIIAGIGTSGHIAGISKYFKERYE-TKIIGVVPAK 180
N + HY T E+ E + K+ +I +AGIGT G I+G+ +Y KER ++IG+ P +
Sbjct: 215 NPKIHYETTGPEIWEDTKG--KV-DIFVAGIGTGGTISGVGRYLKERNPGVQVIGIEPTE 271
Query: 181 GETI----PGIKRLETRPKWFFKVE-----VDEVVEVTAREAFEGILKVARSDGLLIGMS 231
+ PG +++ F +DEV+EV++ EA E ++A +GLL+G+S
Sbjct: 272 SNILSGGKPGPHKIQGLGAGFVPSNLDLGVMDEVIEVSSEEAVEMAKQLAMKEGLLVGIS 331
Query: 232 SGAVVKAYEKV--RPEGTTVLI---FPDDGFKY 259
SGA A ++ RPE LI FP G +Y
Sbjct: 332 SGAAAAAAVRIGKRPENAGKLIAVVFPSFGERY 364
>dbj|BAA21916.1| (AB000266) cysteine synthase [Entamoeba histolytica]
Length = 337
Score = 126 bits (313), Expect = 3e-28
Identities = 88/272 (32%), Positives = 142/272 (51%), Gaps = 22/272 (8%)
Query: 5 KLEFFNPFSRSIKDRAVYNMLIKALRSGEIDGTNVLYEATSGNVGISIAALSAVFGLKFR 64
KLE+FNP S S+KDR +N++ +A++ G + + E+TSGN GI++ AVFG +
Sbjct: 47 KLEYFNPMS-SVKDRVGFNIVYQAIKDGRLKPGMEIIESTSGNTGIALCQAGAVFGYRVN 105
Query: 65 AYIPKPTPKTTELLIKVFGAEVVRTNFDTIDKKFVEFVK--LEARRDKALNLNQFENDAN 122
+P ++++K FGAE++ T +E V ++ K NQF N N
Sbjct: 106 IAMPSTMSVERQMIMKAFGAELILTEGKKGMPGAIEEVNKMIKENPGKYFVANQFGNPDN 165
Query: 123 FEAHYYGTARELEEQLRSIDKIPEIIIAGIGTSGHIAGISKYFKERYE-TKIIGVVPAKG 181
AH+Y TA E+ E D +I+++ +GTSG + G+++ KE+ + KII V P +
Sbjct: 166 TAAHHY-TANEIWE---DTDGEVDIVVSAVGTSGTVIGVAEKLKEKKKGIKIIAVEPEES 221
Query: 182 ETIPGIKR---------LETRPKWFFKVEVDEVVEVTAREAFEGILKVARSDGLLIGMSS 232
+ G + P + K VDE++ + ++A++ V + DG++ GMSS
Sbjct: 222 AVLEGKAKGPHGIQGIGAGFIPDIYKKEFVDEIIPIKTQDAWKMARAVVKYDGIMCGMSS 281
Query: 233 GAVV----KAYEKVRPEG-TTVLIFPDDGFKY 259
GA + K EK EG T V+I P G +Y
Sbjct: 282 GAAILAGLKEAEKPENEGKTIVIIVPSCGERY 313
>sp|P71128|CYSM_CAMJE CYSTEINE SYNTHASE B (O-ACETYLSERINE SULFHYDRYLASE B)
(O-ACETYLSERINE (THIOL)-LYASE B) (CSASE B)
>gi|11269119|pir||G81364 cysteine synthase (EC 4.2.99.8)
Cj0912c [imported] - Campylobacter jejuni (strain NCTC
11168) >gi|6968349|emb|CAB73169.1| (AL139076) cysteine
synthase [Campylobacter jejuni]
Length = 299
Score = 125 bits (311), Expect = 6e-28
Identities = 95/248 (38%), Positives = 135/248 (54%), Gaps = 18/248 (7%)
Query: 3 FAKLEFFNPFSRSIKDRAVYNMLIKALRSGEIDGTNVLYEATSGNVGISIAALSAVFGLK 62
FAK EF NP S SIKDRA + M+ AL S +I+ + EATSGN GIS+A + A GLK
Sbjct: 27 FAKCEFLNP-SHSIKDRAAFEMIKDALDSKKINQDTTIVEATSGNTGISLAMICADLGLK 85
Query: 63 FRAYIPKPTPKTTELLIKVFGAEVVRTNFDTIDKKFVEFV-KLEARRDKALNLNQFENDA 121
F A +P+ +I +FGA + T + K V+ ++ + ++QFEN +
Sbjct: 86 FIAVMPESMSLERRKMITLFGARLELTPANLGMKGAVDKANEILLNTPNSFMVSQFENIS 145
Query: 122 NFEAHYYGTARELEEQLRSIDKIPEIIIAGIGTSGHIAGISKYFKERYE-TKIIGVVP-- 178
N AH TA E+ LR +D +I +AG GT G I+G+ + KE+ E I+GV P
Sbjct: 146 NKNAHRKNTALEI---LRDLDNELDIFVAGFGTGGTISGVGEILKEKLEKVHIVGVEPLN 202
Query: 179 ----AKGET----IPGIKRLETRPKWFFKVEVDEVVEVTAREAFEGILKVARSDGLLIGM 230
+KGE I GI P K +DEV+ V+ +A ++A+S GL++G+
Sbjct: 203 SPLLSKGEAGSHKIQGI-GANFIPAILNKEVIDEVITVSNEDAINTAKELAKS-GLMVGI 260
Query: 231 SSGAVVKA 238
SSGA V A
Sbjct: 261 SSGANVFA 268
>emb|CAB71290.1| (AJ271727) O-acetylserine (thiol) lyase [Arabidopsis thaliana]
Length = 387
Score = 125 bits (311), Expect = 6e-28
Identities = 97/276 (35%), Positives = 147/276 (53%), Gaps = 27/276 (9%)
Query: 4 AKLEFFNPFSRSIKDRAVYNMLIKALRSGEID-GTNVLYEATSGNVGISIAALSAVFGLK 62
AKLE P S+KDR Y+M+ A + G I G +VL E TSGN GI +A ++A G +
Sbjct: 99 AKLEIMEPCC-SVKDRIGYSMVTDAEQKGFISPGKSVLVEPTSGNTGIGLAFIAASRGYR 157
Query: 63 FRAYIPKPTPKTTELLIKVFGAEVVRTN----FDTIDKKFVEFVKLEARRDKALNLNQFE 118
+P +L+K FGAE+V T+ +K E +K A L QF+
Sbjct: 158 LILTMPASMSMERRVLLKAFGAELVLTDPAKGMTGAVQKAEEILK---NTPDAYMLQQFD 214
Query: 119 NDANFEAHYYGTARELEEQLRSIDKIPEIIIAGIGTSGHIAGISKYFKERY-ETKIIGVV 177
N AN + HY T E+ + + K+ +I +AGIGT G I G+ ++ KE+ +T++IGV
Sbjct: 215 NPANPKIHYETTGPEIWDDTKG--KV-DIFVAGIGTGGTITGVGRFIKEKNPKTQVIGVE 271
Query: 178 PAKGETI----PGIKRLE-----TRPKWFFKVEVDEVVEVTAREAFEGILKVARSDGLLI 228
P + + + PG +++ PK + +DEV+ +++ EA E ++A +GL++
Sbjct: 272 PTESDILSGGKPGPHKIQGIGAGFIPKNLDQKIMDEVIAISSEEAIETAKQLALKEGLMV 331
Query: 229 GMSSGAVVKAYEKV--RPEGTTVLI---FPDDGFKY 259
G+SSGA A KV RPE LI FP G +Y
Sbjct: 332 GISSGAAAAAAIKVAKRPENAGKLIAVVFPSFGERY 367
>dbj|BAA88220.1| (AB028632) cysteine synthase 2 [Entamoeba dispar]
Length = 336
Score = 125 bits (310), Expect = 7e-28
Identities = 89/272 (32%), Positives = 141/272 (51%), Gaps = 22/272 (8%)
Query: 5 KLEFFNPFSRSIKDRAVYNMLIKALRSGEIDGTNVLYEATSGNVGISIAALSAVFGLKFR 64
KLE+FNP S S+KDR +N++ +A+++G + + EATSGN GI++ VFG +
Sbjct: 47 KLEYFNPMS-SVKDRVGFNIVYQAIKNGRLKPGMEIIEATSGNTGIALCQAGVVFGYRVN 105
Query: 65 AYIPKPTPKTTELLIKVFGAEVVRTNFDTIDKKFVEFV--KLEARRDKALNLNQFENDAN 122
+P ++++K FGAE++ T +E V KL+ K NQF N N
Sbjct: 106 IVMPSTMSLERQMIMKAFGAELILTEGKKGITGAIEEVNKKLKENPGKYFVANQFGNPDN 165
Query: 123 FEAHYYGTARELEEQLRSIDKIPEIIIAGIGTSGHIAGISKYFKERYE-TKIIGVVPAKG 181
+HYY TA E+ E +I+++ +GTSG + GI++ KE+ + KII V P +
Sbjct: 166 TTSHYY-TANEIWEDTNG---EVDIVVSAVGTSGTVIGIAEKLKEKKKRIKIIAVEPEES 221
Query: 182 ETIPGIKR---------LETRPKWFFKVEVDEVVEVTAREAFEGILKVARSDGLLIGMSS 232
+ G + P + K VDE++ + +EA++ V + +G++ GMSS
Sbjct: 222 AVLEGKPKGPHGIQGIGAGFIPDIYKKEFVDEIIPIKTQEAWKMARIVVKYEGIMCGMSS 281
Query: 233 GAVV----KAYEKVRPEG-TTVLIFPDDGFKY 259
GA + K K EG T V+I P G +Y
Sbjct: 282 GAAILAGLKEAGKSENEGKTIVIIVPSCGERY 313
>sp|O67507|CYSM_AQUAE CYSTEINE SYNTHASE (O-ACETYLSERINE SULFHYDRYLASE) (O-ACETYLSERINE
(THIOL)-LYASE) (CSASE) >gi|7436943|pir||A70435 cysteine
synthase (EC 4.2.99.8) cysM [similarity] - Aquifex
aeolicus >gi|2983909|gb|AAC07459.1| (AE000745) cysteine
synthase, O-acetylserine (thiol) lyase B [Aquifex
aeolicus]
Length = 327
Score = 124 bits (309), Expect = 1e-27
Identities = 88/270 (32%), Positives = 142/270 (52%), Gaps = 17/270 (6%)
Query: 3 FAKLEFFNPFSRSIKDRAVYNMLIKALRSGEIDGTNVLYEATSGNVGISIAALSAVFGLK 62
+AKLE FNP S+KDR +M + AL+ G I V+ +ATSGN GI++A + A G+
Sbjct: 52 WAKLESFNP-GGSVKDRPALSMFLDALKRGLIKEGKVVIDATSGNTGIALAMVGAALGVP 110
Query: 63 FRAYIPKPTPKTTELLIKVFGAEVVRTNFDTIDKKFVEFVK--LEARRDKALNLNQFEND 120
+P + + +IK FGA++ T+ + FV+ ++ +K + L+Q+ N
Sbjct: 111 VELAMPANVSEERKKIIKAFGAKLYLTDPLEGTDGAILFVRELVQKYPEKYVYLDQYNNP 170
Query: 121 ANFEAHYYGTARELEEQLRSIDKIPEIIIAGIGTSGHIAGISKYFK-ERYETKIIGVVPA 179
AN++AH+Y T E+ Q + +I +AGIGT G I G + K ++IGV PA
Sbjct: 171 ANWKAHFYSTGIEIWNQTKG--RITH-FVAGIGTGGTIMGTGRRLKIYNPNIQVIGVQPA 227
Query: 180 -KGETIPGIKRLET--RPKWFFKVEVDEVVEVTAREAFEGILKVARSDGLLIGMSSGA-- 234
I G+K +E+ +P F + +D + V +A+ ++A+ D + +G SSGA
Sbjct: 228 YPFHGIEGLKHIESSIKPGIFDETFLDRTIFVETEDAYYWARELAKKDAIFVGQSSGAAL 287
Query: 235 -----VVKAYEKVRPEGTTVLIFPDDGFKY 259
+ + K +G V +FPD G KY
Sbjct: 288 WACIQLARELAKKGEKGVIVTVFPDGGEKY 317
>emb|CAB71303.1| (AJ130879) o-acetylserine sulfhydrylase [Clostridium sticklandii]
Length = 304
Score = 124 bits (308), Expect = 1e-27
Identities = 82/271 (30%), Positives = 138/271 (50%), Gaps = 19/271 (7%)
Query: 3 FAKLEFFNPFSRSIKDRAVYNMLIKALRSGEIDGTNVLYEATSGNVGISIAALSAVFGLK 62
+ KLEFFNP S+KDRA NM+ + G++ +++ E TSGN GI IA + + G K
Sbjct: 30 YVKLEFFNP-GGSVKDRAALNMIENMEKEGKLKLGDIIVEPTSGNTGIGIAMVGSAKGYK 88
Query: 63 FRAYIPKPTPKTTELLIKVFGAEVVRTNFDTIDKKFVEFVKLEARRDKALNLNQFENDAN 122
+P+ ++K +GAE+V T K + + A+ D + L QF+N N
Sbjct: 89 VILCMPETMSIERRKILKAYGAELVLTEGAKGMKGAIAKAEEMAQEDGYIILRQFDNSYN 148
Query: 123 FEAHYYGTARELEEQLRSIDKIPEIIIAGIGTSGHIAGISKYFKE-RYETKIIGVVPAKG 181
+AHY TA+E+ L +D ++ G+GT G + G++K FKE +I+ V P
Sbjct: 149 VDAHYKNTAKEIISDLPDLD----ALVVGVGTGGTLTGVAKAFKESSINAEIVAVEPVDS 204
Query: 182 ETI----PGIKRLETRPKWFFKVEVD-----EVVEVTAREAFEGILKVARSDGLLIGMSS 232
+ PG +L+ F +D ++ ++ +EAF +A +G+L+G+S
Sbjct: 205 AVLSGNAPGPHKLQGIGAGFVPSILDTEYISKIEQIQTQEAFNASRLMASKEGILLGISG 264
Query: 233 GAVVKA----YEKVRPEGTTVLIFPDDGFKY 259
GA ++A +++ L+ PD+G +Y
Sbjct: 265 GAALEAAIRTAKRLGKGKKVCLLLPDNGERY 295
>pir||S29733 cysteine synthase (EC 4.2.99.8) B precursor, chloroplast - spinach
>gi|312944|emb|CAA47329.1| (X66860) cysteine synthase
[Spinacia oleracea]
Length = 383
Score = 123 bits (305), Expect = 3e-27
Identities = 95/273 (34%), Positives = 142/273 (51%), Gaps = 21/273 (7%)
Query: 4 AKLEFFNPFSRSIKDRAVYNMLIKALRSGEID-GTNVLYEATSGNVGISIAALSAVFGLK 62
AKLE P S+KDR Y+M+ A + G I G L E TSGN GI +A ++A G K
Sbjct: 96 AKLESMEPCC-SVKDRIGYSMIDDAEQKGVITPGKTTLVEPTSGNTGIGLAFIAAARGYK 154
Query: 63 FRAYIPKPTPKTTELLIKVFGAEVVRTNFDTIDKKFVEFV-KLEARRDKALNLNQFENDA 121
+P +++K FGAE+V T+ K VE ++ + + L QF+N A
Sbjct: 155 ITLTMPASMSMERRVILKAFGAELVLTDPAKGMKGAVEKAEEILKKTPDSYMLQQFDNPA 214
Query: 122 NFEAHYYGTARELEEQLRSIDKIPEIIIAGIGTSGHIAGISKYFKERYE-TKIIGVVPAK 180
N + HY T E+ E + K+ +I +AGIGT G I+G+ +Y KER ++IG+ P +
Sbjct: 215 NPKIHYETTGPEIWEDTKG--KV-DIFVAGIGTGGTISGVGRYLKERNPGVQVIGIEPTE 271
Query: 181 GETI----PGIKRLETRPKWFFKVE-----VDEVVEVTAREAFEGILKVARSDGLLIGMS 231
+ PG +++ F +DEV+EV++ EA E ++A +GLL+G+S
Sbjct: 272 SNILSGGKPGPHKIQGLGAGFVPSNLDLGVMDEVIEVSSEEAVEMAKQLAMKEGLLVGIS 331
Query: 232 SGAVVKAYEKV--RPEGTTVLI---FPDDGFKY 259
SG A ++ RPE LI FP G +Y
Sbjct: 332 SGRRAAAAVRIGKRPENAGKLIAVVFPSFGERY 364
>pir||D82312 cysteine synthase B VC0537 [imported] - Vibrio cholerae (group O1
strain N16961) >gi|9654964|gb|AAF93705.1| (AE004139)
cysteine synthase B [Vibrio cholerae]
Length = 295
Score = 122 bits (304), Expect = 4e-27
Identities = 85/261 (32%), Positives = 140/261 (53%), Gaps = 10/261 (3%)
Query: 5 KLEFFNPFSRSIKDRAVYNMLIKALRSGEIDGTNVLYEATSGNVGISIAALSAVFGLKFR 64
KLE NP + S+KDR NM+++A G + + + EATSGN GI++A +A+ G K
Sbjct: 32 KLEGNNP-AGSVKDRPALNMIVQAEARGSLQPGDTIIEATSGNTGIALAMAAAIKGYKMI 90
Query: 65 AYIPKPTPKTTELLIKVFGAEVVRTNFDTIDKKFVEFVKLEARRDKALNLNQFENDANFE 124
+P + + ++ +GAE++ + + + + + K L+QF N N +
Sbjct: 91 LIMPDNATQERKDSMRAYGAELILVSKEQGMEGARDLALQMQQEGKGKVLDQFNNLDNPD 150
Query: 125 AHYYGTARELEEQLRSIDKIPEIIIAGIGTSGHIAGISKYFKERY-ETKIIGVVPAKGET 183
AHY T E+ +Q S KI ++ +GT+G I G+S+Y K++ + +IIG+ P++G
Sbjct: 151 AHYRSTGPEIWQQ--SQGKITH-FVSSMGTTGTIMGVSRYLKQQNPQIQIIGLQPSEGSA 207
Query: 184 IPGIKRLETR--PKWFFKVEVDEVVEVTAREAFEGILKVARSDGLLIGMSSGAVVKAYEK 241
IPGI+R P F VD+V++VT +A + +AR +G+ G+SSG V A +
Sbjct: 208 IPGIRRWPQAYLPGIFDAARVDQVLDVTQTDAEQTARALAREEGICAGVSSGGAVFAALQ 267
Query: 242 V---RPEGTTVLIFPDDGFKY 259
+ P V I D G +Y
Sbjct: 268 IAQQNPGSVVVAIVCDRGDRY 288
>sp|P31300|CYSL_CAPAN CYSTEINE SYNTHASE, CHLOROPLAST PRECURSOR (O-ACETYLSERINE
SULFHYDRYLASE) (O-ACETYLSERINE (THIOL)-LYASE) (CSASE B)
(CS-B) (OAS-TL B) >gi|322740|pir||A43407 cysteine
synthase (EC 4.2.99.8) precursor - pepper
>gi|17944|emb|CAA46086.1| (X64874) O-acetylserine
(thiol)-lyase [Capsicum annuum]
Length = 374
Score = 122 bits (304), Expect = 4e-27
Identities = 99/264 (37%), Positives = 140/264 (52%), Gaps = 13/264 (4%)
Query: 4 AKLEFFNPFSRSIKDRAVYNMLIKALRSGEID-GTNVLYEATSGNVGISIAALSAVFGLK 62
AKLE P S+KDR ++M+ A G I G VL E TSGN GI +A ++A G K
Sbjct: 96 AKLEIMEPCC-SVKDRIGFSMISDAEEKGLISPGKTVLVEPTSGNTGIGLAFIAASRGYK 154
Query: 63 FRAYIPKPTPKTTELLIKVFGAEVVRTNFDTIDKKFV-EFVKLEARRDKALNLNQFENDA 121
+P +++K FGAE+V T+ K V + ++ A L QF+N A
Sbjct: 155 LILTMPASMSLERRVILKAFGAELVLTDPAKGMKGAVSKAEEILNNTPDAYILQQFDNPA 214
Query: 122 NFEAHYYGTARELEEQLRSIDKIPEIIIAGIGTSGHIAGISKYFKERY-ETKIIGVVPAK 180
N + HY T E+ E + KI +I++AGIGT G I+G +Y KE+ KIIGV P +
Sbjct: 215 NPKIHYETTGPEIWEDTKG--KI-DILVAGIGTGGTISGTGRYLKEKNPNIKIIGVEPTE 271
Query: 181 GETIPGIKRLETRPKWFFKVEVDEVVEVTAREAFEGILKVARSDGLLIGMSSGAVVKAYE 240
+ G K P + +DEV+E+++ EA E ++A +GLL+G+SSGA A
Sbjct: 272 SNVLSGGKP-GFIPGNLDQDVMDEVIEISSDEAVETAKQLALQEGLLVGISSGAAALAAI 330
Query: 241 KV--RPEGTTVLI---FPDDGFKY 259
+V RPE LI FP G +Y
Sbjct: 331 QVAKRPENAGKLIAVVFPSFGERY 354
>pir||JC6185 cysteine synthase (EC 4.2.99.8) B - Campylobacter jejuni
>gi|1575474|gb|AAC44853.1| (U63157) O-acetylserine
sulfhydrylase B [Campylobacter jejuni]
Length = 299
Score = 122 bits (303), Expect = 5e-27
Identities = 93/248 (37%), Positives = 135/248 (53%), Gaps = 18/248 (7%)
Query: 3 FAKLEFFNPFSRSIKDRAVYNMLIKALRSGEIDGTNVLYEATSGNVGISIAALSAVFGLK 62
FAK EF NP S SIKDRA + M+ AL S +I+ + EATSGN GIS+A + A GLK
Sbjct: 27 FAKCEFLNP-SHSIKDRAAFEMIKDALDSKKINQDTTIVEATSGNTGISLAMICADLGLK 85
Query: 63 FRAYIPKPTPKTTELLIKVFGAEVVRTNFDTIDKKFVEFV-KLEARRDKALNLNQFENDA 121
F A +P+ + +I +FGA + T + K V+ ++ + ++QFEN +
Sbjct: 86 FVAVMPESMSLERKKMITLFGARLELTPANLGMKGAVDKANEILLNTPNSFMVSQFENIS 145
Query: 122 NFEAHYYGTARELEEQLRSIDKIPEIIIAGIGTSGHIAGISKYFKERYE-TKIIGVVP-- 178
N AH TA E+ LR +D +I +AG GT G I+G+ + KE+ E I+GV P
Sbjct: 146 NKNAHRKNTALEI---LRDLDNELDIFVAGFGTGGTISGVGEILKEKLEKVHIVGVEPLN 202
Query: 179 ----AKGET----IPGIKRLETRPKWFFKVEVDEVVEVTAREAFEGILKVARSDGLLIGM 230
+KGE I GI P K +D+V+ V+ +A ++A+ GL++G+
Sbjct: 203 SPLLSKGEAGSHKIQGI-GANFIPAILNKEVIDQVITVSNEDAINTAKELAKI-GLMVGI 260
Query: 231 SSGAVVKA 238
SSGA V A
Sbjct: 261 SSGANVFA 268
>pir||T47800 cysteine synthase - Arabidopsis thaliana
>gi|7019670|emb|CAB75795.1| (AL138647) cysteine synthase
[Arabidopsis thaliana]
Length = 442
Score = 122 bits (303), Expect = 5e-27
Identities = 93/265 (35%), Positives = 142/265 (53%), Gaps = 24/265 (9%)
Query: 4 AKLEFFNPFSRSIKDRAVYNMLIKALRSGEID-GTNVLYEATSGNVGISIAALSAVFGLK 62
AKLE P S+KDR Y+M+ A + G I G +VL E TSGN GI +A ++A G +
Sbjct: 142 AKLEIMEPCC-SVKDRIGYSMVTDAEQKGFISPGKSVLVEPTSGNTGIGLAFIAASRGYR 200
Query: 63 FRAYIPKPTPKTTELLIKVFGAEVVRTN----FDTIDKKFVEFVKLEARRDKALNLNQFE 118
+P +L+K FGAE+V T+ +K E +K A L QF+
Sbjct: 201 LILTMPASMSMERRVLLKAFGAELVLTDPAKGMTGAVQKAEEILK---NTPDAYMLQQFD 257
Query: 119 NDANFEAHYYGTARELEEQLRSIDKIPEIIIAGIGTSGHIAGISKYFKERY-ETKIIGVV 177
N AN + HY T E+ + + K+ +I +AGIGT G I G+ ++ KE+ +T++IGV
Sbjct: 258 NPANPKIHYETTGPEIWDDTKG--KV-DIFVAGIGTGGTITGVGRFIKEKNPKTQVIGVE 314
Query: 178 PAKGETI----PGIKRLE-----TRPKWFFKVEVDEVVEVTAREAFEGILKVARSDGLLI 228
P + + + PG +++ PK + +DEV+ +++ EA E ++A +GL++
Sbjct: 315 PTESDILSGGKPGPHKIQGIGAGFIPKNLDQKIMDEVIAISSEEAIETAKQLALKEGLMV 374
Query: 229 GMSSGAVVKAYEKV--RPEGTTVLI 251
G+SSGA A KV RPE LI
Sbjct: 375 GISSGAAAAAAIKVAKRPENAGKLI 399
>gb|AAG01804.1|AF276772_3 (AF276772) O-acetylserine sulfhydrylase [Methanosarcina
thermophila]
Length = 308
Score = 122 bits (302), Expect = 6e-27
Identities = 97/274 (35%), Positives = 142/274 (51%), Gaps = 23/274 (8%)
Query: 4 AKLEFFNPFSRSIKDRAVYNMLIKALRSGEIDGTNVLYEATSGNVGISIAALSAVFGLKF 63
AK+E FNP S+KDR M+ +A R G I + EATSGN GI++A + A G
Sbjct: 33 AKVESFNPMG-SVKDRIGLAMIEEAEREGRIKEGTTIIEATSGNTGIALACVCAARGYNL 91
Query: 64 RAYIPKPTPKTTELLIKVFGAEVVRTNFDTIDKKFVEFVKLEARRDKALNL--NQFENDA 121
+P+ L+K GAE+V T+ + V + A D AL QF+N A
Sbjct: 92 ILVMPETMTVERRKLLKALGAELVLTSGAEGMRGAVNKAEQMAADDSALYFIPQQFQNPA 151
Query: 122 NFEAHYYGTARELEEQLRSIDKIPEIIIAGIGTSGHIAGISKYFKERYET-KIIGVVPAK 180
N E H TA EE R D ++I+AG+GT G I GI+ K+R + K I V PA+
Sbjct: 152 NPEIHRRTTA---EEIWRDTDGKADVIVAGVGTGGTITGIASAIKKRRPSFKAIAVEPAE 208
Query: 181 GETI----PGIKRLETRPKWF----FKVE-VDEVVEVTAREAFEGILKVARSDGLLIGMS 231
+ PG R++ F ++E +DE+++VT EA ++A+ +G+L G+S
Sbjct: 209 SPVLSGGSPGPHRIQGIGAGFVPDVLQLELIDEIIKVTGDEAAATARRLAKEEGILAGIS 268
Query: 232 SGAV------VKAYEKVRPEGTTVLIFPDDGFKY 259
SGA V + E++R + T V+I PD G +Y
Sbjct: 269 SGAATWAALQVASREEMRGK-TIVVILPDTGERY 301
>pir||A83530 cysteine synthase B PA0932 [imported] - Pseudomonas aeruginosa
(strain PAO1) >gi|9946836|gb|AAG04321.1|AE004527_8
(AE004527) cysteine synthase B [Pseudomonas aeruginosa]
Length = 299
Score = 122 bits (302), Expect = 6e-27
Identities = 87/262 (33%), Positives = 139/262 (52%), Gaps = 12/262 (4%)
Query: 5 KLEFFNPFSRSIKDRAVYNMLIKALRSGEIDGTNVLYEATSGNVGISIAALSAVFGLKFR 64
KLE NP + S+KDR +M+ +A G+I + L EATSGN GI++A +A+ G K
Sbjct: 34 KLEGNNP-AGSVKDRPALSMITRAELRGDIRPGDTLIEATSGNTGIALAMAAAIKGYKMI 92
Query: 65 AYIPKPTPKTTELLIKVFGAEVVRTNFDTIDKKFVEFVKLEARRDKALNLNQFENDANFE 124
+P + + + +GAE++ + + + + R + L+QF N N E
Sbjct: 93 LIMPDNSTAERKAAMTAYGAELILVSKEEGMEGARDLADKLQREGRGKVLDQFANGDNPE 152
Query: 125 AHYYGTARELEEQL-RSIDKIPEIIIAGIGTSGHIAGISKYFKERY-ETKIIGVVPAKGE 182
AHY+ T E+ +Q SI ++ +GT+G I G+S+Y KE+ +I+G+ P +G
Sbjct: 153 AHYHSTGPEIWQQTGGSITH----FVSSMGTTGTIMGVSRYLKEQNPAVQIVGLQPMEGS 208
Query: 183 TIPGIKR--LETRPKWFFKVEVDEVVEVTAREAFEGILKVARSDGLLIGMSSGAVVKAYE 240
IPGI+R E PK + VD VV++ EA + + ++AR +G+ G+SSG V A
Sbjct: 209 AIPGIRRWPQEYLPKIYDASRVDRVVDMHQDEAEDIMRRLAREEGIFCGVSSGGAVAAML 268
Query: 241 KVRPE---GTTVLIFPDDGFKY 259
++ E V I D G +Y
Sbjct: 269 RLSRELENAVLVAIICDRGDRY 290
>sp|P29848|CYSM_SALTY CYSTEINE SYNTHASE B (O-ACETYLSERINE SULFHYDRYLASE B)
(O-ACETYLSERINE (THIOL)-LYASE B) (CSASE B)
>gi|321910|pir||S29567 cysteine synthase (EC 4.2.99.8) -
Salmonella typhimurium >gi|581757|emb|CAA42164.1|
(X59595) cysteine synthase [Salmonella typhimurium]
Length = 303
Score = 121 bits (300), Expect = 1e-26
Identities = 83/263 (31%), Positives = 142/263 (53%), Gaps = 10/263 (3%)
Query: 3 FAKLEFFNPFSRSIKDRAVYNMLIKALRSGEIDGTNVLYEATSGNVGISIAALSAVFGLK 62
+ KLE NP + S+KDRA +M+++A + GEI +VL EATSGN GI++A ++A+ G +
Sbjct: 28 WVKLEGNNP-AGSVKDRAALSMIVEAEKRGEIKPGDVLIEATSGNTGIALAMIAALKGYR 86
Query: 63 FRAYIPKPTPKTTELLIKVFGAEVVRTNFDTIDKKFVEFVKLEARRDKALNLNQFENDAN 122
+ +P + ++ +GAE++ + + + + R + L+QF N N
Sbjct: 87 MKLLMPDNMSQERRAAMRAYGAELILVTKEQGMEGARDLALAMSERGEGKLLDQFNNPDN 146
Query: 123 FEAHYYGTARELEEQLRSIDKIPEIIIAGIGTSGHIAGISKYFKERYE-TKIIGVVPAKG 181
AHY T E+ Q + +I ++ +GT+G I G+S++ +E+ + I+G+ P +G
Sbjct: 147 PYAHYTTTGPEIWRQ--TSGRITH-FVSSMGTTGTITGVSRFLREQEKPVTIVGLQPEEG 203
Query: 182 ETIPGIKR--LETRPKWFFKVEVDEVVEVTAREAFEGILKVARSDGLLIGMSSGAVVKAY 239
+IPGI+R E P F VDEV+++ +A + ++A +G+ G+SSG V
Sbjct: 204 SSIPGIRRWPAEYMPGIFNASLVDEVLDIHQNDAENTMRELAVREGIFCGVSSGGAVAGA 263
Query: 240 EKV---RPEGTTVLIFPDDGFKY 259
+V P V I D G +Y
Sbjct: 264 LRVARATPGAIVVAIICDRGDRY 286
>sp|O81155|CYSL_SOLTU CYSTEINE SYNTHASE, CHLOROPLAST PRECURSOR (O-ACETYLSERINE
SULFHYDRYLASE) (O-ACETYLSERINE (THIOL)-LYASE) (CSASE B)
(CS-B) (OAS-TL B) >gi|7436944|pir||T07002 cysteine
synthase (EC 4.2.99.8) precursor, chloroplast - potato
>gi|3290022|gb|AAC25636.1| (AF044173) cysteine synthase;
CS-B; O-acetylserine (thiol) lyase; plastidic isoform
[Solanum tuberosum]
Length = 386
Score = 120 bits (298), Expect = 2e-26
Identities = 98/273 (35%), Positives = 142/273 (51%), Gaps = 21/273 (7%)
Query: 4 AKLEFFNPFSRSIKDRAVYNMLIKALRSGEID-GTNVLYEATSGNVGISIAALSAVFGLK 62
AKLE P S+KDR ++M++ A G I G VL E TSGN GI +A ++A G K
Sbjct: 98 AKLEIMEPCC-SVKDRIGFSMIVDAEEKGLISPGKTVLVEPTSGNTGIGLAFIAASRGYK 156
Query: 63 FRAYIPKPTPKTTELLIKVFGAEVVRTNFDTIDKKFV-EFVKLEARRDKALNLNQFENDA 121
+P +++K FGAE+V T+ K V + ++ A L QF+N A
Sbjct: 157 LILTMPASMSLERRVILKAFGAELVLTDPAKGMKGAVSKAEEILNNTPDAYILQQFDNPA 216
Query: 122 NFEAHYYGTARELEEQLRSIDKIPEIIIAGIGTSGHIAGISKYFKERY-ETKIIGVVPAK 180
N + HY T E+ E + KI +I++AGIGT G I G ++ KE+ KIIGV P +
Sbjct: 217 NPKIHYETTGPEIWEDTKG--KI-DILVAGIGTGGTITGTGRFLKEQNPNIKIIGVEPTE 273
Query: 181 GETI----PGIKRLETRPKWFF-----KVEVDEVVEVTAREAFEGILKVARSDGLLIGMS 231
+ PG +++ F + +DEV+E+++ EA E +A +GLL+G+S
Sbjct: 274 SNVLSGGKPGPHKIQGIGAGFIPGNLDQDVMDEVIEISSDEAVETARTLALQEGLLVGIS 333
Query: 232 SGAVVKAYEKV--RPEGTTVLI---FPDDGFKY 259
SGA A +V RPE LI FP G +Y
Sbjct: 334 SGAAALAAIQVGKRPENAGKLIGVVFPSYGERY 366
>dbj|BAA93051.1| (AB040503) cysteine synthase [Allium tuberosum]
Length = 325
Score = 120 bits (297), Expect = 2e-26
Identities = 96/290 (33%), Positives = 150/290 (51%), Gaps = 23/290 (7%)
Query: 4 AKLEFFNPFSRSIKDRAVYNMLIKALRSGEID-GTNVLYEATSGNVGISIAALSAVFGLK 62
AKLE P S S+KDR Y+M+ +A + G I G +VL E TSGN GI +A ++A K
Sbjct: 37 AKLEMMEPCS-SVKDRIGYSMITEAEKQGLITPGVSVLIEPTSGNTGIGLAFMAAAKSYK 95
Query: 63 FRAYIPKPTPKTTELLIKVFGAEVVRTNFDTIDKKFVEFV-KLEARRDKALNLNQFENDA 121
+P +++K FGAE+V T+ K E ++ A+ + L QFEN +
Sbjct: 96 LILTMPASMSLERRIILKAFGAELVLTDPVKGMKGACEKAEEIAAKTPNSYVLQQFENPS 155
Query: 122 NFEAHYYGTARELEEQLRSIDKIPEIIIAGIGTSGHIAGISKYFKERY-ETKIIGVVPAK 180
N + HY T E+ ++ D + +++GIGT G I G KY KE+ K+ GV P +
Sbjct: 156 NPKIHYETTGPEI---WKATDGKIDGLVSGIGTGGTITGSGKYLKEQNPSVKLYGVEPVE 212
Query: 181 GETI----PGIKRLETRPKWFFKVE-----VDEVVEVTAREAFEGILKVARSDGLLIGMS 231
+ PG +++ F +DE ++V++ EA E ++A +GLL+G+S
Sbjct: 213 SAILSGGKPGPHKIQGIGAGFIPGVLDVNLIDETLQVSSEEAIEMAKQLALQEGLLVGIS 272
Query: 232 SGAVVKAYEKV--RPEG---TTVLIFPDDGFKY--GEIFEMLLGEAQGKI 274
SGA A +V RPE V++FP G +Y +F+ + EA+ +
Sbjct: 273 SGAAAIAAIRVAQRPENEGKLIVVVFPSFGERYLSTVLFQSIKKEAESMV 322
>emb|CAC09469.1| (AL442113) cysteine synthase [Oryza sativa]
Length = 377
Score = 120 bits (297), Expect = 2e-26
Identities = 101/288 (35%), Positives = 147/288 (50%), Gaps = 25/288 (8%)
Query: 4 AKLEFFNPFSRSIKDRAVYNMLIKALRSGEID-GTNVLYEATSGNVGISIAALSAVFGLK 62
AKLEF P S S+KDR +ML A + G I G L E TSGN+GI +A ++A+ G +
Sbjct: 87 AKLEFLQP-SFSVKDRPAISMLEDAEKKGLITPGKTTLIEPTSGNMGIGLAFMAALKGYE 145
Query: 63 FRAYIPKPTPKTTELLIKVFGAEVVRTN-FDTIDKKFVEFVKLEARRDKALNLNQFENDA 121
+P T + ++ FGA++V T+ + + +L A L QFEN A
Sbjct: 146 LILTMPSYTSLERRVTMRAFGAKLVLTDPTKGMGGTVRKAAELYENHPSAFMLQQFENPA 205
Query: 122 NFEAHYYGTAREL-EEQLRSIDKIPEIIIAGIGTSGHIAGISKYFKERY-ETKIIGVVPA 179
N + HY T E+ E+ L +D I + GIG+ G + G+ KY KE+ KI GV PA
Sbjct: 206 NVKVHYETTGPEIWEDTLGQVD----IFVMGIGSGGTVTGVGKYLKEKNPNAKIYGVEPA 261
Query: 180 KGETIPGIK---RLETRPKWFFKVEV------DEVVEVTAREAFEGILKVARSDGLLIGM 230
+ + G K L T FK E+ ++V+EV +A + ++A +GLL+G+
Sbjct: 262 EANVLNGGKPGPHLITGNGVGFKPEILNMDIMEKVLEVKGEDAVKMARELALKEGLLVGI 321
Query: 231 SSGA-VVKAYEKV-RPEG---TTVLIFPDDGFKY--GEIFEMLLGEAQ 271
SSGA V A E +PE V + P G +Y +FE L EA+
Sbjct: 322 SSGANTVAALELAKKPENKGKLIVTVLPSLGERYLSSALFEELRAEAE 369
>gi|6321594 Cystathionine beta-synthase; Cys4p [Saccharomyces cerevisiae]
>gi|417825|sp|P32582|CBS_YEAST CYSTATHIONINE
BETA-SYNTHASE (SERINE SULFHYDRASE) (BETA-THIONASE)
>gi|539100|pir||A48661 cystathionine beta-synthase (EC
4.2.1.22) - yeast (Saccharomyces cerevisiae)
>gi|296135|emb|CAA51426.1| (X72922) cystathionine
beta-synthase [Saccharomyces cerevisiae]
>gi|1045260|emb|CAA59812.1| (X85807) ORF G6667
[Saccharomyces cerevisiae] >gi|1323263|emb|CAA97169.1|
(Z72940) ORF YGR155w [Saccharomyces cerevisiae]
Length = 507
Score = 119 bits (296), Expect = 3e-26
Identities = 92/282 (32%), Positives = 145/282 (50%), Gaps = 32/282 (11%)
Query: 3 FAKLEFFNPFSRSIKDRAVYNMLIKALRSGEIDGT-NVLYEATSGNVGISIAALSAVFGL 61
+AKLE +NP SIKDR +M+ +A SG I + + L E TSGN GI +A + A+ G
Sbjct: 40 YAKLELYNP-GGSIKDRIAKSMVEEAEASGRIHPSRSTLIEPTSGNTGIGLALIGAIKGY 98
Query: 62 KFRAYIPKPTPKTTELLIKVFGAEVVRTN----FDTIDKKFVEFVKLEARRDKALNLNQF 117
+ +P+ ++K GAE++RT +D+ + KLE A+ L+Q+
Sbjct: 99 RTIITLPEKMSNEKVSVLKALGAEIIRTPTAAAWDSPESHIGVAKKLEKEIPGAVILDQY 158
Query: 118 ENDANFEAHYYGTARELEEQLRSIDKIPEI--IIAGIGTSGHIAGISKYFKERYE-TKII 174
N N EAHY+GT RE++ QL ++ + ++AG GT G I+GISKY KE+ + +I+
Sbjct: 159 NNMMNPEAHYFGTGREIQRQLEDLNLFDNLRAVVAGAGTGGTISGISKYLKEQNDKIQIV 218
Query: 175 GVVPAKGETIPGIKRLETRPKWFFKVE---------------VDEVVEVTAREAFEGILK 219
G P G + + L +KVE +D + + +F+ +
Sbjct: 219 GADPF-GSILAQPENLNKTDITDYKVEGIGYDFVPQVLDRKLIDVWYKTDDKPSFKYARQ 277
Query: 220 VARSDGLLIGMSSG----AVVKAYE---KVRPEGTTVLIFPD 254
+ ++G+L+G SSG AVVK E ++ + V IFPD
Sbjct: 278 LISNEGVLVGGSSGSAFTAVVKYCEDHPELTEDDVIVAIFPD 319
>dbj|BAA03952.1| (D16502) cystathionine beta-synthase [Saccharomyces cerevisiae]
Length = 507
Score = 119 bits (296), Expect = 3e-26
Identities = 92/282 (32%), Positives = 145/282 (50%), Gaps = 32/282 (11%)
Query: 3 FAKLEFFNPFSRSIKDRAVYNMLIKALRSGEIDGT-NVLYEATSGNVGISIAALSAVFGL 61
+AKLE +NP SIKDR +M+ +A SG I + + L E TSGN GI +A + A+ G
Sbjct: 40 YAKLELYNP-GGSIKDRIAKSMVEEAEASGRIHPSRSTLIEPTSGNTGIGLALIGAIKGY 98
Query: 62 KFRAYIPKPTPKTTELLIKVFGAEVVRTN----FDTIDKKFVEFVKLEARRDKALNLNQF 117
+ +P+ ++K GAE++RT +D+ + KLE A+ L+Q+
Sbjct: 99 RTIITLPEKMSNEKVSVLKALGAEIIRTPTAAAWDSPESHIGVAKKLEKEIPGAVILDQY 158
Query: 118 ENDANFEAHYYGTARELEEQLRSIDKIPEI--IIAGIGTSGHIAGISKYFKERYE-TKII 174
N N EAHY+GT RE++ QL ++ + ++AG GT G I+GISKY KE+ + +I+
Sbjct: 159 NNMMNPEAHYFGTGREIQRQLEDLNLFDNLRAVVAGAGTGGTISGISKYLKEQNDKIQIV 218
Query: 175 GVVPAKGETIPGIKRLETRPKWFFKVE---------------VDEVVEVTAREAFEGILK 219
G P G + + L +KVE +D + + +F+ +
Sbjct: 219 GADPF-GSILAQPENLNKTDITDYKVEGIGYDFVPQVLDRKLIDVWYKTDDKPSFKYARQ 277
Query: 220 VARSDGLLIGMSSG----AVVKAYE---KVRPEGTTVLIFPD 254
+ ++G+L+G SSG AVVK E ++ + V IFPD
Sbjct: 278 LISNEGVLVGGSSGSTFTAVVKYCEDHPELTEDDVIVAIFPD 319
>sp|P80608|CYSK_MAIZE CYSTEINE SYNTHASE (O-ACETYLSERINE SULFHYDRYLASE) (O-ACETYLSERINE
(THIOL)-LYASE) (CSASE) (OAS-TL) >gi|1076798|pir||S52738
cysteine synthase (EC 4.2.99.8) precursor - maize
>gi|758353|emb|CAA59798.1| (X85803) cysteine synthase
[Zea mays]
Length = 325
Score = 119 bits (296), Expect = 3e-26
Identities = 97/292 (33%), Positives = 152/292 (51%), Gaps = 23/292 (7%)
Query: 2 SFAKLEFFNPFSRSIKDRAVYNMLIKALRSGEID-GTNVLYEATSGNVGISIAALSAVFG 60
S AKLE P S S+KDR Y+M+ A G I G +VL E TSGN GI +A ++A G
Sbjct: 35 SRAKLESMEPCS-SVKDRIGYSMITDAEEKGLITPGVSVLIEPTSGNTGIGLAFMAAAKG 93
Query: 61 LKFRAYIPKPTPKTTELLIKVFGAEVVRTNFDTIDKKFVEFV-KLEARRDKALNLNQFEN 119
K +P +++K FGAE+V T+ K V+ +++A+ + L QFEN
Sbjct: 94 YKLTLTMPASMSMERRIILKAFGAELVLTDPLLGMKGAVKKAEEIQAKTPNSYILQQFEN 153
Query: 120 DANFEAHYYGTARELEEQLRSIDKIPEIIIAGIGTSGHIAGISKYFKERY-ETKIIGVVP 178
AN + HY T E+ + + KI + +++GIGT G I G +Y +E+ K+ GV P
Sbjct: 154 PANPKIHYETTGPEIWK--ATAGKI-DGLVSGIGTGGTITGTGRYLREQNPNVKLYGVEP 210
Query: 179 AKGETI----PGIKRLETRPKWFFKVE-----VDEVVEVTAREAFEGILKVARSDGLLIG 229
+ + PG +++ F +DE ++V++ EA E +A +GLL+G
Sbjct: 211 VESAVLNGGKPGPHKIQGIGAGFIPGVLDVDLLDETLQVSSDEAIETAKALALKEGLLVG 270
Query: 230 MSSGAVVKAYEKV--RPEGT---TVLIFPDDGFKY--GEIFEMLLGEAQGKI 274
+SSGA A ++ RPE V++FP G +Y +F+ + EA+ +
Sbjct: 271 ISSGAAAAAAVRLAKRPENAGKLFVVVFPSFGERYLSSVLFQSIKKEAESMV 322
>pir||T07962 probable cysteine synthase (EC 4.2.99.8) 1A precursor -
Chlamydomonas reinhardtii >gi|3342569|gb|AAC27794.1|
(AF078693) putative O-acetylserine(thiol)lyase precursor
[Chlamydomonas reinhardtii]
Length = 352
Score = 119 bits (295), Expect = 4e-26
Identities = 92/286 (32%), Positives = 148/286 (51%), Gaps = 23/286 (8%)
Query: 4 AKLEFFNPFSRSIKDRAVYNMLIKALRSGEID-GTNVLYEATSGNVGISIAALSAVFGLK 62
AKLE P S+KDR Y+M+ A + G I G VL E TSGN GI +A ++A G K
Sbjct: 62 AKLEIMEPCC-SVKDRIGYSMISSAEKEGLITPGKTVLVEPTSGNTGIGLAFIAAARGYK 120
Query: 63 FRAYIPKPTPKTTELLIKVFGAEVVRTN-FDTIDKKFVEFVKLEARRDKALNLNQFENDA 121
+P +L++ FGAE+V T+ + + ++ A A L QF+N
Sbjct: 121 LILTMPASMSLERRILLRAFGAELVLTDPAKGMKGAVAKAEEILASTPDAFMLQQFQNPN 180
Query: 122 NFEAHYYGTARELEEQLRSIDKIPEIIIAGIGTSGHIAGISKYFKE-RYETKIIGVVPAK 180
N + HY T E+ + D +I+++G+GT G I G +Y +E + + +++ V PA+
Sbjct: 181 NPKVHYETTGPEI---WSATDGKVDILVSGVGTGGTITGTGRYLREKKSDVQLVAVEPAE 237
Query: 181 GETI----PGIKRLETRPKWFFKVEVD-----EVVEVTAREAFEGILKVARSDGLLIGMS 231
+ PG +++ F +D EVV+V++ +A + ++A +GL++G+S
Sbjct: 238 SPVLSGGKPGPHKIQGIGAGFVPAVLDTALISEVVQVSSDDAIDMARRLALEEGLMVGIS 297
Query: 232 SGAVVKAYEKV--RPEG---TTVLIFPDDGFKY--GEIFEMLLGEA 270
SGA V+A KV RPE V++ P G +Y +F+ L EA
Sbjct: 298 SGAAVQAAIKVASRPENEGKLVVVVLPPFGERYLSSVLFQQLRDEA 343
>dbj|BAB03807.1| (AP001507) cysteine synthase A [Bacillus halodurans]
Length = 307
Score = 119 bits (295), Expect = 4e-26
Identities = 90/271 (33%), Positives = 134/271 (49%), Gaps = 18/271 (6%)
Query: 3 FAKLEFFNPFSRSIKDRAVYNMLIKALRSGEIDGTNVLYEATSGNVGISIAALSAVFGLK 62
+ KLEFFNP S S+KDR M+ A +SG + + + E TSGN GI +A ++A G K
Sbjct: 31 YLKLEFFNPGS-SVKDRIALAMIEAAEKSGALKPDDTIVEPTSGNTGIGLAMVAAAKGYK 89
Query: 63 FRAYIPKPTPKTTELLIKVFGAEVVRTNFDTIDKKFVEFVKLEARRDKALNLNQFENDAN 122
+ +P+ L++ +GAE+V T + A+ + QFEN+AN
Sbjct: 90 TKLVMPETMSLERRNLLRAYGAELVLTPGPEGMGGAIRKATELAQENGYFMPQQFENEAN 149
Query: 123 FEAHYYGTARELEEQLRSIDKIPEIIIAGIGTSGHIAGISKYFKERY-ETKIIGVVPAKG 181
E H T REL EQ +D + ++GIGT G I G KE + I V PA
Sbjct: 150 PEIHRETTGRELLEQ---VDGQLDGFVSGIGTGGTITGAGGLLKENFPNLHIAAVEPADS 206
Query: 182 ETI----PGIKRLE-----TRPKWFFKVEVDEVVEVTAREAFEGILKVARSDGLLIGMSS 232
+ PG +++ PK DEV++V+ +AFE + A+ +G+L G+SS
Sbjct: 207 PVLSGGNPGPHKIQGIGAGFVPKILDTDIYDEVIKVSTEQAFEYARRAAKEEGILGGISS 266
Query: 233 GAVVKA----YEKVRPEGTTVLIFPDDGFKY 259
GA + A EK+ P V + P +G +Y
Sbjct: 267 GAAIYAALQVAEKLGPGKKVVAVIPSNGERY 297
>emb|CAA71799.1| (Y10846) O-acetylserine(thiol) lyase [Brassica juncea]
Length = 345
Score = 118 bits (294), Expect = 6e-26
Identities = 99/289 (34%), Positives = 141/289 (48%), Gaps = 27/289 (9%)
Query: 4 AKLEFFNPFSRSIKDRAVYNMLIKALRSGEID-GTNVLYEATSGNVGISIAALSAVFGLK 62
AKLE P S S+KDR Y+M+ A G I G + L E T+GN GI +A + A G K
Sbjct: 58 AKLEMMQPCS-SVKDRIAYSMIKDAEDKGLIKPGESTLIEPTAGNTGIGLACIGAARGYK 116
Query: 63 FRAYIPKPTPKTTELLIKVFGAEVVRTNFDTIDKKFVEFVKLEARRDKALN---LNQFEN 119
+P +++K GAE+ T+ K +E K E +K QFEN
Sbjct: 117 VTLLMPSTMSLERRIILKALGAELHLTDMSIGIKGLLE--KTEEMLNKTPGGFVPQQFEN 174
Query: 120 DANFEAHYYGTARELEEQLRSIDKIPEIIIAGIGTSGHIAGISKYFKE-RYETKIIGVVP 178
AN E HY T E+ S K+ +I IAG+GT G + G+ ++ KE + K+I V P
Sbjct: 175 LANPEIHYQTTGPEIWRD--SAGKV-DIFIAGVGTGGTVTGVGRFLKEMNKDIKVIAVEP 231
Query: 179 AKGETI----PGIKRLETRPKWFFKVE-----VDEVVEVTAREAFEGILKVARSDGLLIG 229
+ + PG ++ VDE+++VT EA E +A +GLL+G
Sbjct: 232 TESPVLSGGEPGRHLIQGIGAGIIPANLDLSIVDEIIQVTGEEAIETAKLLALKEGLLVG 291
Query: 230 MSSGAVVKAYEKV--RPEGTTVLI---FPDDGFKY--GEIFEMLLGEAQ 271
+SSGA A KV RPE LI FP G +Y ++F+ + EA+
Sbjct: 292 ISSGAAAAAALKVAKRPENAGKLIAVLFPSGGERYLSTKLFDSVRFEAE 340
>pir||F72349 cysteine synthase (EC 4.2.99.8) TM0665 [similarity] - Thermotoga
maritima (strain MSB8)
>gi|4981187|gb|AAD35748.1|AE001739_11 (AE001739)
cysteine synthase [Thermotoga maritima]
Length = 291
Score = 118 bits (294), Expect = 6e-26
Identities = 90/272 (33%), Positives = 139/272 (51%), Gaps = 21/272 (7%)
Query: 3 FAKLEFFNPFSRSIKDRAVYNMLIKALRSGEIDGTNVLYEATSGNVGISIAALSAVFGLK 62
F KLE NP S+KDR M++ A + G + N + E TSGN+GI+IA + A G +
Sbjct: 22 FLKLEKNNP-GGSVKDRPALFMILDAEKRGLLK--NGIVEPTSGNMGIAIAMIGAKRGHR 78
Query: 63 FRAYIPKPTPKTTELLIKVFGAEVVRTNFDTIDKKFVEFVKLEARRDKALNLNQFENDAN 122
+P+ ++K+ GAE+V T + K VE +R A LNQFEN N
Sbjct: 79 VILTMPETMSVERRKVLKMLGAELVLTPGELGMKGAVEKALEISRETGAHMLNQFENPYN 138
Query: 123 FEAHYYGTARELEEQLRSIDKIPEIIIAGIGTSGHIAGISKYFKERY--ETKIIGVVPAK 180
+H + T E+ L+ +D + +AG+GT G I+G+ + K + KI+ V PAK
Sbjct: 139 VYSHQFTTGPEI---LKQMDYQIDAFVAGVGTGGTISGVGRVLKGFFGNGVKIVAVEPAK 195
Query: 181 GETI----PGIKRLE-----TRPKWFFKVEVDEVVEVTAREAFEGILKVARSDGLLIGMS 231
+ PG ++ PK + +DEV+ V EA+E +A+ +GLL+G+S
Sbjct: 196 SPVLSGGQPGKHAIQGIGAGFVPKILDRSVIDEVITVEDEEAYEMARYLAKKEGLLVGIS 255
Query: 232 SG----AVVKAYEKVRPEGTTVLIFPDDGFKY 259
SG A +K +K+ P+ V + PD +Y
Sbjct: 256 SGANVAAALKVAQKLGPDARVVTVAPDHAERY 287
>gb|AAG28533.1|AF198621_4 (AF198621) cysteine synthase [Bacillus stearothermophilus]
Length = 308
Score = 118 bits (294), Expect = 6e-26
Identities = 91/271 (33%), Positives = 136/271 (49%), Gaps = 18/271 (6%)
Query: 3 FAKLEFFNPFSRSIKDRAVYNMLIKALRSGEIDGTNVLYEATSGNVGISIAALSAVFGLK 62
+ KLEF NP S S+KDR M+ A + G++ + + E TSGN GI +A ++A G K
Sbjct: 32 YLKLEFMNPGS-SVKDRIALAMIEAAEKEGKLKPGDTIIEPTSGNTGIGLAMVAAAKGYK 90
Query: 63 FRAYIPKPTPKTTELLIKVFGAEVVRTNFDTIDKKFVEFVKLEARRDKALNLNQFENDAN 122
+P L++ +GAE+V T + +E + R QF+N+AN
Sbjct: 91 AILVMPDTMSLERRNLLRAYGAELVLTPGSQGMRGAIEKAEELVREHGYFMPQQFKNEAN 150
Query: 123 FEAHYYGTARELEEQLRSIDKIPEIIIAGIGTSGHIAGISKYFKERY-ETKIIGVVPAKG 181
E H T +E+ EQ+ D++ + IAG+GT G I G + +E+Y KI V PA
Sbjct: 151 PEIHRLTTGKEIVEQMG--DQL-DAFIAGVGTGGTITGAGQVLREKYPNIKIYAVEPADS 207
Query: 182 ETI----PGIKRLETRPKWFFKVEV-----DEVVEVTAREAFEGILKVARSDGLLIGMSS 232
+ PG +++ F + DEV+ VT EAF + AR +G+L G+SS
Sbjct: 208 PVLSGGKPGPHKIQGIGAGFVPDVLDTNIYDEVITVTTEEAFAAARRAAREEGILGGISS 267
Query: 233 GAVVKAYEKVRPE---GTTVL-IFPDDGFKY 259
GA + A KV + G VL I P +G +Y
Sbjct: 268 GAAIHAALKVAKQLGKGKKVLAIIPSNGERY 298
>sp|P95230|CYSK_MYCTU CYSTEINE SYNTHASE A (O-ACETYLSERINE SULFHYDRYLASE A)
(O-ACETYLSERINE (THIOL)-LYASE A) (CSASE A)
>gi|7436922|pir||G70660 cysteine synthase (EC 4.2.99.8)
- Mycobacterium tuberculosis (strain H37RV)
>gi|1781241|emb|CAB06151.1| (Z83860) cysK [Mycobacterium
tuberculosis]
Length = 310
Score = 118 bits (293), Expect = 7e-26
Identities = 89/272 (32%), Positives = 136/272 (49%), Gaps = 20/272 (7%)
Query: 4 AKLEFFNPFSRSIKDRAVYNMLIKALRSGEIDGTNVLYEATSGNVGISIAALSAVFGLKF 63
AKLEFFNP + S+KDR ML A ++G I ++ E TSGN GI++A + A G +
Sbjct: 32 AKLEFFNP-ANSVKDRIGVAMLQAAEQAGLIKPDTIILEPTSGNTGIALAMVCAARGYRC 90
Query: 64 RAYIPKPTPKTTELLIKVFGAEVVRT-NFDTIDKKFVEFVKLEARRDKALNLNQFENDAN 122
+P+ +L++ +GAE++ T D + + +L + QFEN AN
Sbjct: 91 VLTMPETMSLERRMLLRAYGAELILTPGADGMSGAIAKAEELAKTDQRYFVPQQFENPAN 150
Query: 123 FEAHYYGTARELEEQLRSIDKIPEIIIAGIGTSGHIAGISKYFKERY-ETKIIGVVPAKG 181
H TA EE R D +I++AG+GT G I G+++ KER + + V PA
Sbjct: 151 PAIHRVTTA---EEVWRDTDGKVDIVVAGVGTGGTITGVAQVIKERKPSARFVAVEPAAS 207
Query: 182 ETIPGIKR---------LETRPKWFFKVEVDEVVEVTAREAFEGILKVARSDGLLIGMSS 232
+ G ++ P + VDE++ V +A ++AR +GLL+G+SS
Sbjct: 208 PVLSGGQKGPHPIQGIGAGFVPPVLDQDLVDEIITVGNEDALNVARRLAREEGLLVGISS 267
Query: 233 GAVVKAYEKV--RPEGT---TVLIFPDDGFKY 259
GA A +V RPE V++ PD G +Y
Sbjct: 268 GAATVAALQVARRPENAGKLIVVVLPDFGERY 299
>gb|AAD23910.1|AF073698_1 (AF073698) cysteine synthase [Oryza sativa]
Length = 339
Score = 118 bits (293), Expect = 7e-26
Identities = 97/276 (35%), Positives = 144/276 (52%), Gaps = 29/276 (10%)
Query: 5 KLEFFNPFSRSIKDRAVYNMLIKALRSGEID-GTNVLYEATSGNVGISIAALSAVFGLKF 63
KLE + P S+KDR+ M+ A G I G L E TSGN+GI +A + + G +F
Sbjct: 54 KLESYQPLC-SVKDRSALRMIEDAEEKGLISPGVTTLVEPTSGNLGIGVAYNALLKGYRF 112
Query: 64 RAYIPKPTPKTTELLIKVFGAEVVRTN-----FDTIDKKFVEFVKLEARRDKALNLNQFE 118
A +P ++L+ GAEV+ T+ +DK VE +K + +L+QF+
Sbjct: 113 VAVMPAEYSLDKQMLLTYLGAEVILTDPTLGFQGQLDK--VEQIKNDM--PNVHHLDQFK 168
Query: 119 NDANFEAHYYGTARELEEQLRSIDKIPEIIIAGIGTSGHIAGISKYFKERYET-KIIGVV 177
N AN EAH+ T E+ + + K+ +I +AG GT G I+G+ KY K + K+I V
Sbjct: 169 NAANPEAHFVWTGPEIWKD--TAGKV-DIFVAGSGTGGTISGVGKYLKMKNPAVKVICVE 225
Query: 178 PAKGETIPGIKRLETR---------PKWFFKVEVDEVVEVTAREAFEGILKVARSDGLLI 228
PA+ I G K + PK VDE++ VTA++A ++AR +GLL+
Sbjct: 226 PAESPVISGGKPSRHKIQGMGPGFVPKNLDISIVDEIITVTAQDAMANAKRLAREEGLLV 285
Query: 229 GMSSGAVVKAYEKVRP----EGTTVL-IFPDDGFKY 259
G+SSGA + A KV EG ++ IFP G +Y
Sbjct: 286 GISSGANLAACLKVASRKEYEGKMIVTIFPSGGERY 321
>dbj|BAA03947.1| (D16496) cystathionine beta-synthase [Saccharomyces cerevisiae]
Length = 507
Score = 118 bits (292), Expect = 9e-26
Identities = 90/281 (32%), Positives = 141/281 (50%), Gaps = 30/281 (10%)
Query: 3 FAKLEFFNPFSRSIKDRAVYNMLIKALRSGEIDGT-NVLYEATSGNVGISIAALSAVFGL 61
+AKLE +NP SIKDR +M+ +A SG I + + L E TSGN GI +A + A+ G
Sbjct: 40 YAKLELYNP-GGSIKDRIAKSMVEEAEASGRIHPSRSTLIEPTSGNTGIGLALIGAIKGY 98
Query: 62 KFRAYIPKPTPKTTELLIKVFGAEVVRTN----FDTIDKKFVEFVKLEARRDKALNLNQF 117
+ +P+ ++K GAE++RT +D+ + KLE A+ L+Q+
Sbjct: 99 RTIITLPEKMSNEKVSVLKALGAEIIRTPTAAAWDSPESHIGVAKKLEKEIPGAVILDQY 158
Query: 118 ENDANFEAHYYGTARELEEQLRSIDKIPEI--IIAGIGTSGHIAGISKYFKERYETKIIG 175
N N EAHY+GT RE++ QL ++ + ++AG GT G I+GISKY KE+ + I
Sbjct: 159 NNMMNPEAHYFGTGREIQRQLEDLNLFDNLRAVVAGAGTGGTISGISKYLKEQNDKIQIV 218
Query: 176 VVPAKGETIPGIKRLETRPKWFFKVE---------------VDEVVEVTAREAFEGILKV 220
G + + L +KVE +D + + +F+ ++
Sbjct: 219 GAEGFGSILAQPENLNKTDITDYKVEGIGYDFVPQVLDRKLIDVWYKTDDKPSFKYARQL 278
Query: 221 ARSDGLLIGMSSG----AVVKAYE---KVRPEGTTVLIFPD 254
++G+L+G SSG AVVK E ++ + V IFPD
Sbjct: 279 ISNEGVLVGGSSGSTFTAVVKYCEDHPELTEDDVIVAIFPD 319
>sp|O34476|CYSM_BACSU PROBABLE CYSTEINE SYNTHASE (O-ACETYLSERINE SULFHYDRYLASE)
(O-ACETYLSERINE (THIOL)-LYASE) (CSASE)
>gi|7436924|pir||H69994 cysteine synthase (EC 4.2.99.8)
ytkP - Bacillus subtilis >gi|2293314|gb|AAC00392.1|
(AF008220) putative cysteine synthase [Bacillus
subtilis] >gi|2635481|emb|CAB14975.1| (Z99119) similar
to cysteine synthase [Bacillus subtilis]
Length = 311
Score = 118 bits (292), Expect = 9e-26
Identities = 84/272 (30%), Positives = 135/272 (48%), Gaps = 16/272 (5%)
Query: 3 FAKLEFFNPFSRSIKDRAVYNMLIKALRSGEIDGTNVLYEATSGNVGISIAALSAVFGLK 62
+ KLEFFNP S S+KDRA Y M+I+A ++G + +V+ E TSGN GI +A +A G K
Sbjct: 32 YLKLEFFNP-SGSVKDRAAYQMIIEAEQNGLLKPGSVIIEPTSGNTGIGLAMNAAARGYK 90
Query: 63 FRAYIPKPTPKTTELLIKVFGAEVVRT-NFDTIDKKFVEFVKLEARRDKALNLNQFENDA 121
+P K L+K +GAEVV T + + + +L + + QF+N A
Sbjct: 91 AILVMPDTMTKERINLLKAYGAEVVLTPGEERMPGSIKKAKELAEQIPNSYIPMQFDNTA 150
Query: 122 NFEAHYYGTARELEEQLRSIDKIPEIIIAGIGTSGHIAGISKYFKERYETKIIGVVPAKG 181
N +AH TA E+ + I K +A GT G I G + KE + + VV G
Sbjct: 151 NPDAHRKTTAPEIARAIEEIGKPLGAFVASSGTGGTITGTGEALKELFPDITVHVVEPAG 210
Query: 182 ETI-----PGIKRLETRPKWFF-----KVEVDEVVEVTAREAFEGILKVARSDGLLIGMS 231
+ PG +L F + DE+++++ +A+ ++A +G+L+G S
Sbjct: 211 SPVLSGGKPGAHKLVGTSPGFIPPILNEDVYDEIIKISDEDAYTTTRRLAAEEGILVGPS 270
Query: 232 SG----AVVKAYEKVRPEGTTVLIFPDDGFKY 259
SG A ++ +++ P+ V + D G +Y
Sbjct: 271 SGAACFAAIETAKRLSPDKVVVCMTADTGERY 302
>sp|Q9XEA6|CYK1_ORYSA CYSTEINE SYNTHASE (O-ACETYLSERINE SULFHYDRYLASE) (O-ACETYLSERINE
(THIOL)-LYASE) (CSASE) (OAS-TL)
>gi|4574135|gb|AAD23907.1|AF073695_1 (AF073695) cysteine
synthase [Oryza sativa]
Length = 321
Score = 117 bits (291), Expect = 1e-25
Identities = 95/290 (32%), Positives = 149/290 (50%), Gaps = 23/290 (7%)
Query: 4 AKLEFFNPFSRSIKDRAVYNMLIKALRSGEID-GTNVLYEATSGNVGISIAALSAVFGLK 62
AKLE P S S+KDR Y+M+ A G I G +VL E TSGN GI +A ++A G +
Sbjct: 34 AKLESMEPCS-SVKDRIGYSMITDAEEKGLITPGKSVLIEPTSGNTGIGLAFMAAAKGYR 92
Query: 63 FRAYIPKPTPKTTELLIKVFGAEVVRTNFDTIDKKFVEFV-KLEARRDKALNLNQFENDA 121
+P +++K FGAE++ T+ K V+ +L A+ + + L QFEN A
Sbjct: 93 LVLTMPASMSMERRIILKAFGAELILTDPLLGMKGAVQKAEELAAKTNNSFILQQFENPA 152
Query: 122 NFEAHYYGTARELEEQLRSIDKIPEIIIAGIGTSGHIAGISKYFKERY-ETKIIGVVPAK 180
N + HY T E+ + + +++GIGT G I G +Y +E+ + KI GV P +
Sbjct: 153 NPKIHYETTGPEI---WKGTGGKVDGLVSGIGTGGTITGTGRYLREQNPDIKIYGVEPVE 209
Query: 181 GETI----PGIKRLETRPKWFFKVEVD-----EVVEVTAREAFEGILKVARSDGLLIGMS 231
+ PG +++ F +D E V+V++ EA E +A +GLL+G+S
Sbjct: 210 SAVLSGGKPGPHKIQGIGAGFVPGVLDVDLINETVQVSSDEAIEMAKALALKEGLLVGIS 269
Query: 232 SGAVVKAYEKV--RPEG---TTVLIFPDDGFKY--GEIFEMLLGEAQGKI 274
SGA A ++ RPE V++FP G +Y +F+ + EA+ +
Sbjct: 270 SGAAAAAAVRLAQRPENEGKLFVVVFPSFGERYLSSVLFQSIKKEAENMV 319
>pir||H81161 probable cysteine synthase (EC 4.2.99.8) NMA0974 [imported] -
Neisseria meningitidis (group B strain MD58, group A
strain Z2491) >gi|7225993|gb|AAF41176.1| (AE002430)
cysteine synthase [Neisseria meningitidis MC58]
>gi|7379677|emb|CAB84244.1| (AL162754) putative cysteine
synthase [Neisseria meningitidis Z2491]
Length = 310
Score = 117 bits (291), Expect = 1e-25
Identities = 86/272 (31%), Positives = 140/272 (50%), Gaps = 21/272 (7%)
Query: 5 KLEFFNPFSRSIKDRAVYNMLIKALRSGEIDGTNVLYEATSGNVGISIAALSAVFGLKFR 64
KLEFFNP S S+KDR M+ A ++G+I+ V+ EATSGN G+ +A + A G K
Sbjct: 33 KLEFFNPGS-SVKDRIAEAMIEGAEKAGKINKNTVIVEATSGNTGVGLAMVCAARGYKLA 91
Query: 65 AYIPKPTPKTTELLIKVFGAEVVRTNFDTIDKKFVEFVK--LEARRDKALNLNQFENDAN 122
+P+ K ++L++ FGAE++ T + K ++A D QF+N+AN
Sbjct: 92 ITMPESMSKERKMLLRAFGAELILTPAAEGMAGAIAKAKSLVDAHPDTYFMPRQFDNEAN 151
Query: 123 FEAHYYGTARELEEQLRSIDKIPEIIIAGIGTSGHIAGISKYFKE-RYETKIIGVVPAKG 181
E H TA EE R D ++ +AG+GT G I G+ + K+ + E K++ V P
Sbjct: 152 PEVHRKTTA---EEIWRDTDGKVDVFVAGVGTGGTITGVGEVLKKYKPEVKVVAVEPEAS 208
Query: 182 ETIPGIKR----LETRPKWFFKVEV-----DEVVEVTAREAFEGILKVARSDGLLIGMSS 232
+ G ++ ++ F + D + +V+ AFE +A +G+L+G+SS
Sbjct: 209 PVLSGGEKGPHPIQGIGAGFIPTVLNTKIYDSITKVSNEAAFETARAIAEKEGILVGISS 268
Query: 233 GAVVKAYEKV--RPEG---TTVLIFPDDGFKY 259
GA V + ++ +PE V++ P G +Y
Sbjct: 269 GAAVWSALQLAKQPENEGKLIVVLLPSYGERY 300
>dbj|BAB06990.1| (AP001518) cysteine synthase [Bacillus halodurans]
Length = 312
Score = 117 bits (291), Expect = 1e-25
Identities = 92/274 (33%), Positives = 140/274 (50%), Gaps = 20/274 (7%)
Query: 3 FAKLEFFNPFSRSIKDRAVYNMLIKALRSGEIDGTNVLYEATSGNVGISIAALSAVFGLK 62
+ K+E FNP S S+KDRA Y M+++A + G + + + E TSGN GI +A +A G
Sbjct: 31 YLKMEMFNP-SGSVKDRAAYQMIVQAEKDGYLKPGSTIIEPTSGNTGIGLAMNAAARG-- 87
Query: 63 FRAYIPKPTPKTTEL--LIKVFGAEVVRTNFDTIDKKFVEFV-KLEARRDKALNLNQFEN 119
+RA + P + E L+K +GAEVV T + +E +L + QFEN
Sbjct: 88 YRAILTMPDTMSEERINLLKAYGAEVVLTEGEKKMPGAIEKAHELVREIPNSFMPMQFEN 147
Query: 120 DANFEAHYYGTARELEEQLRSIDKIPEIIIAGIGTSGHIAGISKYFKERYETKIIGVVPA 179
AN +AH + TA E+++ L SI K +A GT G I G + K+ Y I VV
Sbjct: 148 SANPDAHRFTTAVEIKKALDSIGKKLSAFVAASGTGGTITGTGEELKKFYPNVEIHVVEP 207
Query: 180 KGETI-----PGIKRL-ETRPKW---FFKVEVDEVVE-VTAREAFEGILKVARSDGLLIG 229
G + PG +L T P + +V +V++ + +A+E +AR +G+L+G
Sbjct: 208 FGSPVLSGGKPGPHKLVGTSPGFVPPILNQDVYDVIDKIKDEDAYEAARNLARLEGILVG 267
Query: 230 MSSG----AVVKAYEKVRPEGTTVLIFPDDGFKY 259
SSG A +K E++ P+ V I D G +Y
Sbjct: 268 PSSGAACYAAMKVAERLAPDEVVVCIACDTGERY 301
>pir||T43792 cysteine synthase (EC 4.2.99.8) cysK [similarity] - Clostridium
perfringens >gi|5106358|dbj|BAA81640.1| (AB028629)
cysteine synthase [Clostridium perfringens]
Length = 302
Score = 117 bits (290), Expect = 2e-25
Identities = 87/272 (31%), Positives = 142/272 (51%), Gaps = 21/272 (7%)
Query: 3 FAKLEFFNPFSRSIKDRAVYNMLIKALRSGEIDGTNVLYEATSGNVGISIAALSAVFGLK 62
+AK+E +P S KDR M+ KA + G++ + + EAT+GN GI IA + G K
Sbjct: 31 YAKIEGTSP-GGSCKDRVGIYMVEKAEKEGKLKPGSTIIEATAGNTGIGIALAAINKGYK 89
Query: 63 FRAYIPKPTPKTTELLIKVFGAEVVRTNFDTIDKKFVEFV-KLEARRDKALNLNQFENDA 121
+P + ++K GAE++ T + + + L + +L+LNQF+N+A
Sbjct: 90 IIFIVPDKFSIEKQKIMKALGAEIINTPKEEGMEGAINLANSLLSEIPNSLSLNQFKNEA 149
Query: 122 NFEAHYYGTARELEEQLRSIDKIPEIIIAGIGTSGHIAGISKYFKERYETKIIGVVPAKG 181
N AHY T REL + +D + +AG G+ G I+G+ K+ KE +++ G++
Sbjct: 150 NPLAHYETTGRELYD---GLDGEIDYFVAGAGSGGTISGVLKFLKENI-SEVKGILADPV 205
Query: 182 ETIPGIKRLETR----------PKWFFKVEVDEVVEVTAREAFEGILKVARSDGLLIGMS 231
+I G + T P+ VD+V++V EAF+ + +A+ +GL++G S
Sbjct: 206 GSIIGGGQCGTYKIEGIGNNFIPETMDMSLVDDVIKVNDEEAFDAVKLLAKKEGLIVGSS 265
Query: 232 SG----AVVKAYEKVRPEGTTVLIFPDDGFKY 259
SG AV+K EK+ +G V IFPD G +Y
Sbjct: 266 SGAAFAAVLKLAEKIE-KGNIVTIFPDRGDRY 296
>sp|Q43317|CYSK_CITLA CYSTEINE SYNTHASE (O-ACETYLSERINE SULFHYDRYLASE) (O-ACETYLSERINE
(THIOL)-LYASE) (CSASE) (OAS-TL) >gi|1071911|pir||S46438
cysteine synthase (EC 4.2.99.8) - watermelon
>gi|540497|dbj|BAA05965.1| (D28777) cysteine synthase
[Citrullus lanatus]
Length = 325
Score = 116 bits (289), Expect = 2e-25
Identities = 94/290 (32%), Positives = 146/290 (49%), Gaps = 23/290 (7%)
Query: 4 AKLEFFNPFSRSIKDRAVYNMLIKALRSGEID-GTNVLYEATSGNVGISIAALSAVFGLK 62
AKLE P S S+KDR Y+M+ A G I G +VL E TSGN GI +A ++A G +
Sbjct: 37 AKLEMMEPCS-SVKDRIGYSMISDAENKGLITPGESVLIEPTSGNTGIGLAFIAAAKGYR 95
Query: 63 FRAYIPKPTPKTTELLIKVFGAEVVRTNFDTIDKKFVEFV-KLEARRDKALNLNQFENDA 121
+P +++ FGAE+V T+ K V+ +++A+ + L QFEN A
Sbjct: 96 LIICMPASMSLERRTILRAFGAELVLTDPARGMKGAVQKAEEIKAKTPNSYILQQFENPA 155
Query: 122 NFEAHYYGTARELEEQLRSIDKIPEIIIAGIGTSGHIAGISKYFKERY-ETKIIGVVPAK 180
N + HY T E+ R + +++GIGT G + G KY KE+ K+ GV P +
Sbjct: 156 NPKIHYETTGPEI---WRGSGGKIDALVSGIGTGGTVTGAGKYLKEQNPNIKLYGVEPVE 212
Query: 181 GETI----PGIKRLETRPKWFFKVE-----VDEVVEVTAREAFEGILKVARSDGLLIGMS 231
+ PG +++ F +DEV++V++ E+ E +A +GLL+G+S
Sbjct: 213 SAILSGGKPGPHKIQGIGAGFIPGVLDVNLLDEVIQVSSEESIETAKLLALKEGLLVGIS 272
Query: 232 SGAVVKAYEKV--RPEGT---TVLIFPDDGFKY--GEIFEMLLGEAQGKI 274
SGA A ++ RPE V +FP G +Y +FE + E + +
Sbjct: 273 SGAAAAAAIRIAKRPENAGKLIVAVFPSFGERYLSTVLFESVKRETENMV 322
>sp|P38076|CYSK_WHEAT CYSTEINE SYNTHASE (O-ACETYLSERINE SULFHYDRYLASE) (O-ACETYLSERINE
(THIOL)-LYASE) (CSASE A) (OAS-TL A)
>gi|280415|pir||JS0762 cysteine synthase (EC 4.2.99.8)
precursor - wheat >gi|218335|dbj|BAA02438.1| (D13153)
O-acetylserine (thiol) lyase [Triticum aestivum]
Length = 325
Score = 116 bits (288), Expect = 3e-25
Identities = 97/290 (33%), Positives = 148/290 (50%), Gaps = 23/290 (7%)
Query: 4 AKLEFFNPFSRSIKDRAVYNMLIKALRSGEI-DGTNVLYEATSGNVGISIAALSAVFGLK 62
AKLE P S S+KDR Y+M+ A G I G +VL E TSGN GI +A ++A G +
Sbjct: 38 AKLESMEPCS-SVKDRIGYSMITDAEEKGFIVPGKSVLIEPTSGNTGIGLAFMAAAKGYR 96
Query: 63 FRAYIPKPTPKTTELLIKVFGAEVVRTNFDTIDKKFVEFV-KLEARRDKALNLNQFENDA 121
+P +++K FGAE++ T+ K V+ +L A+ + L QFEN A
Sbjct: 97 LVLTMPASMSMERRIILKAFGAELILTDPLLGMKGAVQKAEELAAKTPNSYILQQFENAA 156
Query: 122 NFEAHYYGTARELEEQLRSIDKIPEIIIAGIGTSGHIAGISKYFKERY-ETKIIGVVPAK 180
N + HY T E+ + KI + +++GIGT G I G KY +E+ K+ GV P +
Sbjct: 157 NPKIHYETTGPEIWKGTGG--KI-DGLVSGIGTGGTITGTGKYLQEQNPNIKLYGVEPTE 213
Query: 181 GETI----PGIKRLETRPKWFFKVE-----VDEVVEVTAREAFEGILKVARSDGLLIGMS 231
+ PG +++ F +DE ++V++ E+ E +A +GLL+G+S
Sbjct: 214 SAILNGGKPGPHKIQGIGAGFIPGVLDVDIIDETIQVSSDESIEMAKSLALKEGLLVGIS 273
Query: 232 SGAVVKAYEKV--RPEGT---TVLIFPDDGFKY--GEIFEMLLGEAQGKI 274
SGA A KV RPE V++FP G +Y +F + EA+ +
Sbjct: 274 SGAAAAAAIKVAQRPENAGKLFVVVFPSFGERYLSSVLFHSIKKEAESMV 323
>sp|P47999|CYSL_ARATH CYSTEINE SYNTHASE, CHLOROPLAST PRECURSOR (O-ACETYLSERINE
SULFHYDRYLASE) (O-ACETYLSERINE (THIOL)-LYASE) (CSASE)
Length = 392
Score = 116 bits (288), Expect = 3e-25
Identities = 99/277 (35%), Positives = 142/277 (50%), Gaps = 29/277 (10%)
Query: 4 AKLEFFNPFSRSIKDRAVYNMLIKALRSGEID-GTNVLYEATSGNVGISIAALSAVFGLK 62
AKLE P S+KDR Y+M+ A G I G +VL E+TSGN GI +A ++A G K
Sbjct: 104 AKLEIMEPCC-SVKDRIGYSMITDAEEKGLITPGKSVLVESTSGNTGIGLAFIAASKGYK 162
Query: 63 FRAYIPKPTPKTTELLIKVFGAEVVRT----NFDTIDKKFVEFVKLEARRDKALNLNQFE 118
+P +L++ FGAE+V T +K E +K + + L QF+
Sbjct: 163 LILTMPASMSLERRVLLRAFGAELVLTEPAKGMTGAIQKAEEILK---KLPNSYMLQQFD 219
Query: 119 NDANFEAHYYGTARELEEQLRSIDKIPEIIIAGIGTSGHIAGISKYFKE-RYETKIIGVV 177
N AN + HY T E+ E R KI +I++AGIGT G I G+ K+ + E K+IGV
Sbjct: 220 NPANPKIHYETTGPEIWEDTRG--KI-DILVAGIGTGGTITGVVDSLKKAKPELKVIGVE 276
Query: 178 PAKGETI----PGIKRLE-----TRPKWFFKVEVDEVVEVTAREAFEGILKVARSDGLLI 228
P + PG +++ PK VDE + +++ EA E ++A +GLL+
Sbjct: 277 PTESLYFLVENPGPHKIQGIGAGFVPKNLDLAIVDEYIAISSEEAIETSKQLALQEGLLV 336
Query: 229 GMSSGAVVKA---YEKVRPEGTTVLI---FPDDGFKY 259
G+SSGA A ++K RPE LI FP G +Y
Sbjct: 337 GISSGAAAAAAIQFDK-RPENAGKLIAVVFPSFGERY 372
>dbj|BAA78562.1| (AB024284) cysteine synthase [Arabidopsis thaliana]
>gi|5931627|emb|CAB56637.1| (AJ011603) cysteine synthase
[Arabidopsis thaliana]
Length = 324
Score = 115 bits (286), Expect = 5e-25
Identities = 95/289 (32%), Positives = 148/289 (50%), Gaps = 27/289 (9%)
Query: 4 AKLEFFNPFSRSIKDRAVYNMLIKALRSGEID-GTNVLYEATSGNVGISIAALSAVFGLK 62
AKLE P S S+K+R Y M+ A G I G + L EATSGN GI +A + A G K
Sbjct: 37 AKLEMMEPCS-SVKERIAYGMIKDAEDKGLITPGKSTLIEATSGNTGIGLAFIGAAKGYK 95
Query: 63 FRAYIPKPTPKTTELLIKVFGAEVVRTNFDTIDKKFVEFVK-LEARRDKALNLNQFENDA 121
+P ++++ GAEV T+ + ++ + + ++ ++ L QF+N +
Sbjct: 96 VVLTMPSSMSLERKIILLALGAEVHLTDPSKGVQGIIDKAEEICSKNPDSIMLEQFKNPS 155
Query: 122 NFEAHYYGTAREL-EEQLRSIDKIPEIIIAGIGTSGHIAGISKYFKERYET-KIIGVVPA 179
N + HY T E+ + +D I++AG+GT G ++G ++ KE+ + K+ GV P
Sbjct: 156 NPQTHYRTTGPEIWRDSAGEVD----ILVAGVGTGGTLSGSGRFLKEKNKDFKVYGVEPT 211
Query: 180 KGETI----PGIKRLE------TRPKWFFKVEVDEVVEVTAREAFEGILKVARSDGLLIG 229
+ I PG ++ F V +DEV++VT+ EA E +A +GLL+G
Sbjct: 212 ESAVISGGKPGTHLIQGIGAGLIPDNLDFNV-LDEVIQVTSVEAIETAKLLALKEGLLVG 270
Query: 230 MSSGAVVKAYEKV--RPEGT---TVLIFPDDGFKY--GEIFEMLLGEAQ 271
+SSGA A KV RPE V+IFP G +Y +FE + EA+
Sbjct: 271 ISSGAAAAAAIKVAKRPENAGKLIVVIFPSGGERYLSTSLFESVRHEAE 319
>gb|AAD56995.1|AC009465_9 (AC009465) putative cysteine synthase; 39489-37437 [Arabidopsis
thaliana]
Length = 399
Score = 115 bits (286), Expect = 5e-25
Identities = 95/289 (32%), Positives = 148/289 (50%), Gaps = 27/289 (9%)
Query: 4 AKLEFFNPFSRSIKDRAVYNMLIKALRSGEID-GTNVLYEATSGNVGISIAALSAVFGLK 62
AKLE P S S+K+R Y M+ A G I G + L EATSGN GI +A + A G K
Sbjct: 112 AKLEMMEPCS-SVKERIAYGMIKDAEDKGLITPGKSTLIEATSGNTGIGLAFIGAAKGYK 170
Query: 63 FRAYIPKPTPKTTELLIKVFGAEVVRTNFDTIDKKFVEFVK-LEARRDKALNLNQFENDA 121
+P ++++ GAEV T+ + ++ + + ++ ++ L QF+N +
Sbjct: 171 VVLTMPSSMSLERKIILLALGAEVHLTDPSKGVQGIIDKAEEICSKNPDSIMLEQFKNPS 230
Query: 122 NFEAHYYGTAREL-EEQLRSIDKIPEIIIAGIGTSGHIAGISKYFKERYET-KIIGVVPA 179
N + HY T E+ + +D I++AG+GT G ++G ++ KE+ + K+ GV P
Sbjct: 231 NPQTHYRTTGPEIWRDSAGEVD----ILVAGVGTGGTLSGSGRFLKEKNKDFKVYGVEPT 286
Query: 180 KGETI----PGIKRLE------TRPKWFFKVEVDEVVEVTAREAFEGILKVARSDGLLIG 229
+ I PG ++ F V +DEV++VT+ EA E +A +GLL+G
Sbjct: 287 ESAVISGGKPGTHLIQGIGAGLIPDNLDFNV-LDEVIQVTSVEAIETAKLLALKEGLLVG 345
Query: 230 MSSGAVVKAYEKV--RPEGT---TVLIFPDDGFKY--GEIFEMLLGEAQ 271
+SSGA A KV RPE V+IFP G +Y +FE + EA+
Sbjct: 346 ISSGAAAAAAIKVAKRPENAGKLIVVIFPSGGERYLSTSLFESVRHEAE 394
>pir||T44614 cysteine synthase (EC 4.2.99.8) A [similarity] - Methanosarcina
barkeri >gi|6318842|gb|AAF07039.1|AF174138_1 (AF174138)
O-acetylserine(thiol)-lyase-A related protein
[Methanosarcina barkeri]
Length = 308
Score = 115 bits (286), Expect = 5e-25
Identities = 95/273 (34%), Positives = 131/273 (47%), Gaps = 21/273 (7%)
Query: 4 AKLEFFNPFSRSIKDRAVYNMLIKALRSGEIDGTNVLYEATSGNVGISIAALSAVFGLKF 63
AK+E FNP S+KDR M+ KA G+I + EATSGN GI +A + A G K
Sbjct: 33 AKVESFNPMG-SVKDRIGLAMIEKAELEGKIKKGTTVIEATSGNTGIGLACVCAARGYKL 91
Query: 64 RAYIPKPTPKTTELLIKVFGAEVVRTNFDTIDKKFVEFVKLEARRDKALNL--NQFENDA 121
+P+ L+K GAE+V T K V + A D +L QF+N A
Sbjct: 92 ILVMPETMTVERRKLLKALGAELVLTPGTEGMKGAVNKAEQMAADDPSLYFIAQQFQNPA 151
Query: 122 NFEAHYYGTARELEEQLRSIDKIPEIIIAGIGTSGHIAGISKYFKERYET-KIIGVVPAK 180
N E H TA EE R D ++I+AG+GT G I G++ K+R K I V PA+
Sbjct: 152 NPEIHRRTTA---EEIWRDTDGKADVIVAGVGTGGTITGVASVLKKRKPAFKAIAVEPAE 208
Query: 181 GETI----PGIKRLETRPKWFFKVE-----VDEVVEVTAREAFEGILKVARSDGLLIGMS 231
+ PG +++ F VDEV+ VT A ++A+ +G+L G+S
Sbjct: 209 SPVLSGGSPGPHKIQGIGAGFIPDVLQLDLVDEVIRVTGDNAAAMSRRLAKEEGILAGIS 268
Query: 232 SGAVVKAYEKVRPE-----GTTVLIFPDDGFKY 259
SGA A +V T V+I PD G +Y
Sbjct: 269 SGAATYAALQVAAREEMNGKTIVVILPDTGERY 301
>pir||S48695 cysteine synthase (EC 4.2.99.8) isoform 7-4 precursor, chloroplast
- Arabidopsis thaliana
Length = 392
Score = 115 bits (284), Expect = 8e-25
Identities = 99/277 (35%), Positives = 141/277 (50%), Gaps = 29/277 (10%)
Query: 4 AKLEFFNPFSRSIKDRAVYNMLIKALRSGEID-GTNVLYEATSGNVGISIAALSAVFGLK 62
AKLE P S+KDR Y+M+ A G I G +VL E+TSGN GI +A ++A G K
Sbjct: 104 AKLEIMEPCC-SVKDRIGYSMITDAEEKGLITPGKSVLVESTSGNTGIGLAFIAASKGYK 162
Query: 63 FRAYIPKPTPKTTELLIKVFGAEVVRT----NFDTIDKKFVEFVKLEARRDKALNLNQFE 118
+P +L++ FGAE+V T +K E +K + + L QF+
Sbjct: 163 LILTMPASMSLERRVLLRAFGAELVLTEPAKGMTGAIQKAEEILK---KLPNSYMLQQFD 219
Query: 119 NDANFEAHYYGTARELEEQLRSIDKIPEIIIAGIGTSGHIAGISKYFKE-RYETKIIGVV 177
N AN + HY T E+ E R KI I++AGIGT G I G+ K+ + E K+IGV
Sbjct: 220 NPANPKIHYETTGPEIWEDTRG--KI-VILVAGIGTGGTITGVVDSLKKAKPELKVIGVE 276
Query: 178 PAKGETI----PGIKRLE-----TRPKWFFKVEVDEVVEVTAREAFEGILKVARSDGLLI 228
P + PG +++ PK VDE + +++ EA E ++A +GLL+
Sbjct: 277 PTESLYFLVENPGPHKIQGIGAGFVPKNLDLAIVDEYIAISSEEAIETSKQLALQEGLLV 336
Query: 229 GMSSGAVVKA---YEKVRPEGTTVLI---FPDDGFKY 259
G+SSGA A ++K RPE LI FP G +Y
Sbjct: 337 GISSGAAAAAAIQFDK-RPENAGKLIAVVFPSFGERY 372
>sp|O81154|CYSK_SOLTU CYSTEINE SYNTHASE (O-ACETYLSERINE SULFHYDRYLASE) (O-ACETYLSERINE
(THIOL)-LYASE) (CSASE A) (CS-A) (OAS-TL A)
>gi|7436946|pir||T07001 cysteine synthase (EC 4.2.99.8),
cytosolic - potato >gi|3290020|gb|AAC25635.1| (AF044172)
cysteine synthase; CS-A; O-acetylserine (thiol) lyase;
cytosolic isoform [Solanum tuberosum]
Length = 325
Score = 114 bits (283), Expect = 1e-24
Identities = 98/287 (34%), Positives = 150/287 (52%), Gaps = 23/287 (8%)
Query: 4 AKLEFFNPFSRSIKDRAVYNMLIKALRSGEID-GTNVLYEATSGNVGISIAALSAVFGLK 62
AKLE P S S+KDR Y+M+ A G I G +VL E TSGN G+ +A ++A G K
Sbjct: 37 AKLESMEPCS-SVKDRIGYSMITDAEEKGLIKPGESVLIEPTSGNTGVGLAFMAAAKGYK 95
Query: 63 FRAYIPKPTPKTTELLIKVFGAEVVRTNFDTIDKKFVEFVK-LEARRDKALNLNQFENDA 121
+P ++++ F +E+V T+ K + + ++A+ + L QFEN A
Sbjct: 96 LIITMPSSMSLERRIILRGFRSELVLTDPAKGMKGAISKAEEIKAKTPNSYILQQFENPA 155
Query: 122 NFEAHYYGTARELEEQLRSIDKIPEIIIAGIGTSGHIAGISKYFKERY-ETKIIGVVPAK 180
N + HY T E+ + S K+ + + +GIGT G I G KY +E+ K+ GV P +
Sbjct: 156 NPKIHYETTGPEIWKG--SNGKV-DALASGIGTGGTITGSGKYLREQNPNVKLYGVEPVE 212
Query: 181 GETI----PGIKRLETRPKWFFK--VEV---DEVVEVTAREAFEGILKVARSDGLLIGMS 231
+ PG +++ F +EV D+VV+V++ E+ E +A +GLL+G+S
Sbjct: 213 SAILSGGKPGPHKIQGIGAGFIPGVLEVNLIDDVVQVSSEESIEMAKLLALKEGLLVGIS 272
Query: 232 SGAVVKAYEKV--RPEGT---TVLIFPDDGFKY--GEIFEMLLGEAQ 271
SGA A KV RPE V+IFP G +Y +FE + EA+
Sbjct: 273 SGAAAAAAIKVAKRPENAGKLIVVIFPSFGERYLSSVLFETVRREAE 319
>sp|O32978|CYSK_MYCLE CYSTEINE SYNTHASE A (O-ACETYLSERINE SULFHYDRYLASE A)
(O-ACETYLSERINE (THIOL)-LYASE A) (CSASE A)
>gi|11269115|pir||T44912 cysteine synthase (EC 4.2.99.8)
[similarity] - Mycobacterium leprae
>gi|2342631|emb|CAB11412.1| (Z98741) cysteine synthase
[Mycobacterium leprae]
Length = 310
Score = 114 bits (282), Expect = 1e-24
Identities = 94/273 (34%), Positives = 138/273 (50%), Gaps = 22/273 (8%)
Query: 4 AKLEFFNPFSRSIKDRAVYNMLIKALRSGEIDGTNVLYEATSGNVGISIAALSAVFGLKF 63
AKLE FNP + S+KDR M+ A +G I V+ E TSGN GI++A + A G
Sbjct: 32 AKLESFNP-ANSVKDRIGVAMIDTAEEAGLIKPDTVILEPTSGNTGIALAMVCAARGYHC 90
Query: 64 RAYIPKPTPKTTELLIKVFGAEVVRT-NFDTIDKKFVEFVKLEARRDKALNL-NQFENDA 121
+P+ +L++ +GAE++ T D + + +L A+ DK + QFEN A
Sbjct: 91 VLTMPETMSIERRMLLRAYGAELILTPGADGMSGAIAKAEEL-AKSDKRYFIPQQFENPA 149
Query: 122 NFEAHYYGTARELEEQLRSIDKIPEIIIAGIGTSGHIAGISKYFKERY-ETKIIGVVPAK 180
N H TA EE R D +I ++GIGT G I G+++ KER T+ + V PA
Sbjct: 150 NPAIHAATTA---EEVWRDTDGKVDIFVSGIGTGGTITGVARIIKERRPATQFVAVEPAA 206
Query: 181 GETIPGIKR---------LETRPKWFFKVEVDEVVEVTAREAFEGILKVARSDGLLIGMS 231
+ G ++ P VDE+V V EA + ++A+ +GLL+G+S
Sbjct: 207 SPVLSGGQKGPHPIQGIGAGFVPSVLVLDLVDEIVTVGNEEALDLARRLAKEEGLLVGIS 266
Query: 232 SGAVVKAYEKV--RPEGT---TVLIFPDDGFKY 259
+GA V A V RPE T V++ PD G +Y
Sbjct: 267 AGAAVCAALHVARRPENTGKLIVVVLPDFGERY 299
>dbj|BAA88219.1| (AB028631) cysteine synthase 1 [Entamoeba dispar]
Length = 336
Score = 114 bits (282), Expect = 1e-24
Identities = 84/280 (30%), Positives = 137/280 (48%), Gaps = 38/280 (13%)
Query: 5 KLEFFNPFSRSIKDRAVYNMLIKALRSGEIDGTNVLYEATSGNVGISIAALSAVFGLKFR 64
KLE FNP S S+KDR +N++ +A++ G + + EATSGN GI + AVFG
Sbjct: 47 KLECFNPMS-SVKDRVGFNIVYQAIKDGRLKPGMEIIEATSGNTGIGLCQAGAVFGYPVN 105
Query: 65 AYIPKPTPKTTELLIKVFGAEVVRTN----FDTIDKKFVEFVKLEARRDKALNLNQFEND 120
+P ++++K FGA +V ++ K+ + +K +K NQF N
Sbjct: 106 IVMPSTMSIERQMIMKAFGANLVLSDGTKGMPGAIAKYEDLIK--QHPNKYFPANQFGNP 163
Query: 121 ANFEAHYYGTARELEEQLRSIDKIPEIIIAGIGTSGHIAGISKYFKERYE-TKIIGVVPA 179
N AH Y TA E+ E +II++ +GT+G + G+ + K++ + K++ V P
Sbjct: 164 DNTAAHIY-TANEIWEDTNG---EVDIIVSAVGTAGTVIGVGENLKKKKQGVKVVAVEPE 219
Query: 180 KGETIPGIKRLETRPKW---------------FFKVEVDEVVEVTAREAFEGILKVARSD 224
+ + G +PK + K VDE++ + ++A++ + D
Sbjct: 220 ESAVLSG------KPKGPHGIQGIGAGFVTDIYKKEVVDEIITIKTQDAWKMARATVKYD 273
Query: 225 GLLIGMSSGAVV----KAYEKVRPEG-TTVLIFPDDGFKY 259
G++ GMSSGA + K K EG T V+I PD G +Y
Sbjct: 274 GIMCGMSSGAAILAGLKEAGKAENEGKTIVIILPDCGERY 313
>gb|AAC37401.1| (L14578) cystathionine beta-synthase [Saccharomyces cerevisiae]
Length = 506
Score = 112 bits (278), Expect = 4e-24
Identities = 91/282 (32%), Positives = 143/282 (50%), Gaps = 33/282 (11%)
Query: 3 FAKLEFFNPFSRSIKDRAVYNMLIKALRSGEIDGT-NVLYEATSGNVGISIAALSAVFGL 61
+AKLE +NP SIKDR +M ++A SG I + + L E TSGN GI +A + A+ G
Sbjct: 40 YAKLELYNP-GGSIKDRIAKSM-VEAEASGRIHPSRSTLIEPTSGNTGIGLALIGAIKGY 97
Query: 62 KFRAYIPKPTPKTTELLIKVFGAEVVRT----NFDTIDKKFVEFVKLEARRDKALNLNQF 117
+ P+ ++K GAE++RT +D+ + KLE A+ L+Q+
Sbjct: 98 RTIITWPEKMSNEKVSVLKALGAEIIRTPTVAAWDSPESHIGVAKKLEKEIPGAVILDQY 157
Query: 118 ENDANFEAHYYGTARELEEQLRSIDKIPEI--IIAGIGTSGHIAGISKYFKERYE-TKII 174
N EAHY+GT RE++ QL ++ + ++AG GT G I+GISKY KE+ + +I+
Sbjct: 158 NNMMTPEAHYFGTGREIQRQLEDLNLFDNLRAVVAGAGTGGTISGISKYLKEQNDKIQIV 217
Query: 175 GVVPAKGETIPGIKRLETRPKWFFKVE---------------VDEVVEVTAREAFEGILK 219
G P G + + L +KVE +D + + +F+ +
Sbjct: 218 GADPF-GSILAQPENLNKTDITDYKVEGIGYDFVPQVLDRKLIDVWYKTDDKPSFKYARQ 276
Query: 220 VARSDGLLIGMSSG----AVVKAYE---KVRPEGTTVLIFPD 254
+ ++G+L+G SSG AVVK E ++ + V IFPD
Sbjct: 277 LISNEGVLVGGSSGSAFTAVVKYCEDHPELTEDDVIVAIFPD 318
>sp|P37887|CYSK_BACSU CYSTEINE SYNTHASE (O-ACETYLSERINE SULFHYDRYLASE) (O-ACETYLSERINE
(THIOL)-LYASE) (CSASE) (SUPEROXIDE-INDUCIBLE PROTEIN 11)
(SOI11) >gi|2126922|pir||S66103 cysteine synthase (EC
4.2.99.8) A - Bacillus subtilis
>gi|467462|dbj|BAA05308.1| (D26185) cysteine synthetase
A [Bacillus subtilis] >gi|2632340|emb|CAB11849.1|
(Z99104) cysteine synthetase A [Bacillus subtilis]
Length = 308
Score = 112 bits (277), Expect = 5e-24
Identities = 91/271 (33%), Positives = 133/271 (48%), Gaps = 17/271 (6%)
Query: 3 FAKLEFFNPFSRSIKDRAVYNMLIKALRSGEIDGTNVLYEATSGNVGISIAALSAVFGLK 62
+ KLE+ NP S S+KDR M+ A + G++ N + E TSGN GI +A ++A GLK
Sbjct: 32 YLKLEYMNPGS-SVKDRIGLAMIEAAEKEGKLKAGNTIIEPTSGNTGIGLAMVAAAKGLK 90
Query: 63 FRAYIPKPTPKTTELLIKVFGAEVVRTNFDTIDKKFVEFVKLEARRDKALNLNQFENDAN 122
+P L++ +GAE+V T K ++ + A + QF N +N
Sbjct: 91 AILVMPDTMSMERRNLLRAYGAELVLTPGAEGMKGAIKKAEELAEKHGYFVPQQFNNPSN 150
Query: 123 FEAHYYGTARELEEQLRSIDKIPEIIIAGIGTSGHIAGISKYFKERYET-KIIGVVPAKG 181
E H T +E+ EQ D + +AGIGT G I G + KE Y + KI V P+
Sbjct: 151 PEIHRQTTGKEIVEQFG--DDQLDAFVAGIGTGGTITGAGEVLKEAYPSIKIYAVEPSDS 208
Query: 182 ETI----PGIKRLETRPKWF----FKVEV-DEVVEVTAREAFEGILKVARSDGLLIGMSS 232
+ PG +++ F EV DE+ V EAFE + AR +G+L G+SS
Sbjct: 209 PVLSGGKPGPHKIQGIGAGFVPDILNTEVYDEIFPVKNEEAFEYARRAAREEGILGGISS 268
Query: 233 GAVVKAYEKVRP---EGTTVL-IFPDDGFKY 259
GA + A +V +G VL I P +G +Y
Sbjct: 269 GAAIYAALQVAKKLGKGKKVLAIIPSNGERY 299
>sp|O23735|CYK2_BRAJU CYSTEINE SYNTHASE (O-ACETYLSERINE SULFHYDRYLASE) (O-ACETYLSERINE
(THIOL)-LYASE) (CSASE) (OAS-TL) (OAS-TL6)
>gi|2243124|emb|CAA71800.1| (Y10847)
O-acetylserine(thiol) lyase [Brassica juncea]
Length = 324
Score = 112 bits (277), Expect = 5e-24
Identities = 92/273 (33%), Positives = 137/273 (49%), Gaps = 21/273 (7%)
Query: 4 AKLEFFNPFSRSIKDRAVYNMLIKALRSGEID-GTNVLYEATSGNVGISIAALSAVFGLK 62
AKLE P S S+KDR ++M+ A + G I G +VL E TSGN G+ +A +A G K
Sbjct: 36 AKLEMMEPCS-SVKDRIGFSMISDAEKKGLIKPGESVLIEPTSGNTGVGLAFTAAAKGYK 94
Query: 63 FRAYIPKPTPKTTELLIKVFGAEVVRTN-FDTIDKKFVEFVKLEARRDKALNLNQFENDA 121
+P +++ FG E+V T+ + + ++ A+ L QFEN A
Sbjct: 95 LIITMPASMSIERRIILLAFGVELVLTDPAKGMKGAIAKAEEILAKTPNGYMLQQFENPA 154
Query: 122 NFEAHYYGTARELEEQLRSIDKIPEIIIAGIGTSGHIAGISKYFKERY-ETKIIGVVPAK 180
N + HY T E+ + KI + I+GIGT G I G KY KE+ K+ GV P +
Sbjct: 155 NPKIHYETTGPEIWKGTEG--KI-DGFISGIGTGGTITGAGKYLKEQNPNVKLYGVEPVE 211
Query: 181 GETI----PGIKRLETRPKWFFKVE-----VDEVVEVTAREAFEGILKVARSDGLLIGMS 231
+ PG +++ F +DEVV+V++ E+ + +AR +GLL+G+S
Sbjct: 212 SAILSGGKPGPHKIQGIGAGFIPNVLETNLIDEVVQVSSDESIDMARLLAREEGLLVGIS 271
Query: 232 SGAVVKAYEKV--RPEGT---TVLIFPDDGFKY 259
SGA A K+ RPE V +FP G +Y
Sbjct: 272 SGAAAAAAIKLAKRPENAGKLFVAVFPSFGERY 304
>sp|Q9ZMW6|CYSM_HELPJ CYSTEINE SYNTHASE (O-ACETYLSERINE SULFHYDRYLASE) (O-ACETYLSERINE
(THIOL)-LYASE) (CSASE) >gi|7436931|pir||E71973 cysteine
synthase (EC 4.2.99.8) cysK [similarity] - Helicobacter
pylori (strain J99) >gi|4154606|gb|AAD05678.1|
(AE001449) CYSTEINE SYNTHASE [Helicobacter pylori J99]
Length = 305
Score = 111 bits (276), Expect = 7e-24
Identities = 93/275 (33%), Positives = 138/275 (49%), Gaps = 26/275 (9%)
Query: 3 FAKLEFFNPFSRSIKDRAVYNMLIKALRSGEIDGTNVLYEATSGNVGISIAALSAVFGLK 62
+AKLE NP S+KDR ++ +A R+ +I T + E T+GN GI++A ++ LK
Sbjct: 32 YAKLEHLNP-GGSVKDRLGQYLIKEAFRTRKITSTTTIIEPTAGNTGIALALVAIKHHLK 90
Query: 63 FRAYIPKPTPKTTELLIKVFGAEVVRT----NFDTIDKKFVEFVKLEARRDKALNLNQFE 118
+PK + +++ GA V+ T KK E E+ D L L QFE
Sbjct: 91 TIFVVPKKFSTEKQQIMRALGALVINTPTSEGISGAIKKSKELA--ESIPDSYLPL-QFE 147
Query: 119 NDANFEAHYYGTARELEEQLRSIDKIPEIIIAGIGTSGHIAGISKYFKERY-ETKIIGVV 177
N N A+Y+ A E+ ++L + +AGIG+ G AG++KY KER ++IGV
Sbjct: 148 NPDNPAAYYHTLAPEIVQELGT---NLTSFVAGIGSGGTFAGMAKYLKERIPNIRLIGVE 204
Query: 178 PAKG---------ETIPGIKRLETRPKWFFKVEVDEVVEVTAREAFEGILKVARSDGLLI 228
P I GI +E P +F +++D ++ E F K+A+ +GLL+
Sbjct: 205 PEGSILNGGEPGPHEIEGI-GVEFIPPFFANLDIDRFETISDEEGFSYTRKLAKKNGLLV 263
Query: 229 GMSSGAVVKAYEKV---RPEGTTVL-IFPDDGFKY 259
G SSGA A K PEG+ VL IFPD +Y
Sbjct: 264 GSSSGAAFAAALKEVQRLPEGSQVLTIFPDMADRY 298
>dbj|BAA78561.1| (AB024283) cysteine synthase [Arabidopsis thaliana]
Length = 323
Score = 111 bits (275), Expect = 9e-24
Identities = 96/289 (33%), Positives = 144/289 (49%), Gaps = 27/289 (9%)
Query: 4 AKLEFFNPFSRSIKDRAVYNMLIKALRSGEID-GTNVLYEATSGNVGISIAALSAVFGLK 62
AKLE P S S+KDR Y+M+ A G I G + L E T+GN GI +A + A G K
Sbjct: 36 AKLEMMEPCS-SVKDRIAYSMIKDAEDKGLITPGKSTLIEPTAGNTGIGLACMGAARGYK 94
Query: 63 FRAYIPKPTPKTTELLIKVFGAEVVRTNFDTIDKKFVEFVKLEARRDKALN---LNQFEN 119
+P ++++ GAE+ ++ K +E K EA K QFEN
Sbjct: 95 VILVMPSTMSLERRIILRALGAELHLSDQRIGLKGMLE--KTEAILSKTPGGYIPQQFEN 152
Query: 120 DANFEAHYYGTARELEEQLRSIDKIPEIIIAGIGTSGHIAGISKYFKERY-ETKIIGVVP 178
AN E HY T E+ S K+ +I++AG+GT G G+ K+ KE+ + K+ V P
Sbjct: 153 PANPEIHYRTTGPEIWRD--SAGKV-DILVAGVGTGGTATGVGKFLKEQNKDIKVCVVEP 209
Query: 179 AKGETI----PGIKRLETRPKWF--FKVE---VDEVVEVTAREAFEGILKVARSDGLLIG 229
+ + PG ++ F ++ VDE+++V EA E +A +GLL+G
Sbjct: 210 VESPVLSGGQPGPHLIQGIGSGIVPFNLDLTIVDEIIQVAGEEAIETAKLLALKEGLLVG 269
Query: 230 MSSGAVVKAYEKV--RPEGT---TVLIFPDDGFKY--GEIFEMLLGEAQ 271
+SSGA A KV RPE V++FP G +Y ++F+ + EA+
Sbjct: 270 ISSGAAAAAALKVAKRPENAGKLIVVVFPSGGERYLSTKLFDSIRYEAE 318
>sp|O23733|CYK1_BRAJU CYSTEINE SYNTHASE (O-ACETYLSERINE SULFHYDRYLASE) (O-ACETYLSERINE
(THIOL)-LYASE) (CSASE) (OAS-TL) (OAS-TL4)
>gi|2243120|emb|CAA71798.1| (Y10845)
O-acetylserine(thiol) lyase [Brassica juncea]
Length = 322
Score = 111 bits (274), Expect = 1e-23
Identities = 90/273 (32%), Positives = 138/273 (49%), Gaps = 21/273 (7%)
Query: 4 AKLEFFNPFSRSIKDRAVYNMLIKALRSGEID-GTNVLYEATSGNVGISIAALSAVFGLK 62
AKLE P S S+KDR ++M+ A + G I G +VL E TSGN G+ +A +A G K
Sbjct: 34 AKLEMMEPCS-SVKDRIGFSMISDAEQKGLIKPGESVLIEPTSGNTGVGLAFTAAAKGYK 92
Query: 63 FRAYIPKPTPKTTELLIKVFGAEVVRTN-FDTIDKKFVEFVKLEARRDKALNLNQFENDA 121
+P +++ FG E+V T+ + + ++ A+ L QFEN A
Sbjct: 93 LIITMPASMSVERRIILLAFGVELVLTDPAKGMKGAIAKAEEILAKTPNGYMLQQFENPA 152
Query: 122 NFEAHYYGTARELEEQLRSIDKIPEIIIAGIGTSGHIAGISKYFKERY-ETKIIGVVPAK 180
N + HY T E+ + D + ++GIGT G I G KY KE+ K+ GV P +
Sbjct: 153 NPKIHYETTGPEI---WKGTDGKIDGFVSGIGTGGTITGAGKYLKEQNPNVKLYGVEPIE 209
Query: 181 GETI----PGIKRLETRPKWF----FKVE-VDEVVEVTAREAFEGILKVARSDGLLIGMS 231
+ PG +++ F +V+ +DEVV+V++ E+ + +A +GLL+G+S
Sbjct: 210 SAILSGGKPGPHKIQGIGAGFIPSVLEVDLIDEVVQVSSDESIDMARLLALKEGLLVGIS 269
Query: 232 SGAVVKAYEKV--RPEGT---TVLIFPDDGFKY 259
SGA A K+ RPE V +FP G +Y
Sbjct: 270 SGAAAAAAIKLAKRPENAGKLFVAVFPSFGERY 302
>pir||A71412 cysteine synthase (EC 4.2.99.8) 3A, cytosolic - Arabidopsis
thaliana >gi|2244845|emb|CAB10267.1| (Z97337) cytosolic
O-acetylserine(thiol)lyase (EC 4.2.99.8) [Arabidopsis
thaliana] >gi|6967145|emb|CAB72932.1| (AJ272027)
O-acetylserine (thiol) lyase A1 [Arabidopsis thaliana]
>gi|6983574|emb|CAA56593.2| (X80376) O-acetylserine
(thiol) lyase [Arabidopsis thaliana]
>gi|7268234|emb|CAB78530.1| (AL161540) cytosolic
O-acetylserine(thiol)lyase (EC 4.2.99.8) [Arabidopsis
thaliana]
Length = 322
Score = 111 bits (274), Expect = 1e-23
Identities = 91/273 (33%), Positives = 137/273 (49%), Gaps = 21/273 (7%)
Query: 4 AKLEFFNPFSRSIKDRAVYNMLIKALRSGEID-GTNVLYEATSGNVGISIAALSAVFGLK 62
AKLE P S S+KDR ++M+ A + G I G +VL E TSGN G+ +A +A G K
Sbjct: 34 AKLEMMEPCS-SVKDRIGFSMISDAEKKGLIKPGESVLIEPTSGNTGVGLAFTAAAKGYK 92
Query: 63 FRAYIPKPTPKTTELLIKVFGAEVVRTN-FDTIDKKFVEFVKLEARRDKALNLNQFENDA 121
+P +++ FG E+V T+ + + ++ A+ L QFEN A
Sbjct: 93 LIITMPASMSTERRIILLAFGVELVLTDPAKGMKGAIAKAEEILAKTPNGYMLQQFENPA 152
Query: 122 NFEAHYYGTARELEEQLRSIDKIPEIIIAGIGTSGHIAGISKYFKER-YETKIIGVVPAK 180
N + HY T E+ + KI + ++GIGT G I G KY KE+ K+ GV P +
Sbjct: 153 NPKIHYETTGPEIWKGTGG--KI-DGFVSGIGTGGTITGAGKYLKEQNANVKLYGVEPVE 209
Query: 181 GETI----PGIKRLETRPKWFFKVE-----VDEVVEVTAREAFEGILKVARSDGLLIGMS 231
+ PG +++ F +DEVV+V++ E+ + ++A +GLL+G+S
Sbjct: 210 SAILSGGKPGPHKIQGIGAGFIPSVLNVDLIDEVVQVSSDESIDMARQLALKEGLLVGIS 269
Query: 232 SGAVVKAYEKV--RPEGT---TVLIFPDDGFKY 259
SGA A K+ RPE V IFP G +Y
Sbjct: 270 SGAAAAAAIKLAQRPENAGKLFVAIFPSFGERY 302
>pir||S65533 cysteine synthase (EC 4.2.99.8) 3A - Arabidopsis thaliana
>gi|804950|emb|CAA58893.1| (X84097) cysteine synthase
[Arabidopsis thaliana] >gi|1096196|prf||2111276A Ser(Ac)
thiol lyase [Arabidopsis thaliana]
Length = 322
Score = 110 bits (272), Expect = 2e-23
Identities = 91/273 (33%), Positives = 137/273 (49%), Gaps = 21/273 (7%)
Query: 4 AKLEFFNPFSRSIKDRAVYNMLIKALRSGEID-GTNVLYEATSGNVGISIAALSAVFGLK 62
AKLE P S S+KDR ++M+ A + G I G +VL E TSGN G+ +A +A G K
Sbjct: 34 AKLEMMEPCS-SVKDRIGFSMISDAEKKGLIKPGESVLIEPTSGNTGVGLAFTAAAKGYK 92
Query: 63 FRAYIPKPTPKTTELLIKVFGAEVVRTN-FDTIDKKFVEFVKLEARRDKALNLNQFENDA 121
+P +++ FG E+V T+ + + ++ A+ L QFEN A
Sbjct: 93 LIITMPASMSTERRIILLAFGVELVLTDPAKGMKGAIAKAEEILAKTPNGYMLQQFENPA 152
Query: 122 NFEAHYYGTARELEEQLRSIDKIPEIIIAGIGTSGHIAGISKYFKER-YETKIIGVVPAK 180
N + HY T E+ + KI + ++GIGT G I G KY KE+ K+ GV P +
Sbjct: 153 NPKIHYETTGPEIWKGTGG--KI-DGFVSGIGTGGTITGAGKYLKEQNANVKLYGVEPVE 209
Query: 181 GETI----PGIKRLETRPKWFFKVE-----VDEVVEVTAREAFEGILKVARSDGLLIGMS 231
+ PG +++ F +DEVV+V++ E+ + ++A +GLL+G+S
Sbjct: 210 SAILSGGKPGPHKIQGIGAGFIPSVLNVDLIDEVVQVSSDESIDMARQLALKEGLLVGIS 269
Query: 232 SGAVVKAYEKV--RPEGT---TVLIFPDDGFKY 259
SGA A K+ RPE V IFP G +Y
Sbjct: 270 SGAEAAAAIKLAQRPENAGKLFVAIFPSFGERY 302
>sp|Q43725|CYSM_ARATH CYSTEINE SYNTHASE, MITOCHONDRIAL PRECURSOR (O-ACETYLSERINE
SULFHYDRYLASE) (O-ACETYLSERINE (THIOL)-LYASE) (CSASE)
>gi|1488519|emb|CAA57498.1| (X81973) cysteine synthase
[Arabidopsis thaliana]
Length = 424
Score = 109 bits (271), Expect = 3e-23
Identities = 90/274 (32%), Positives = 140/274 (50%), Gaps = 29/274 (10%)
Query: 4 AKLEFFNPFSRSIKDRAVYNMLIKALRSGEID-GTNVLYEATSGNVGISIAALSAVFGLK 62
AKLE P S+KDR Y+M+ A + G I G +VL E TSGN GI +A +++ G +
Sbjct: 136 AKLEIMEPCC-SVKDRIGYSMVTDAEQKGFISPGKSVLVEPTSGNTGIGLAFIASR-GYR 193
Query: 63 FRAYIPKPTPKTTELLIKVFGAEVVRTN----FDTIDKKFVEFVKLEARRDKALNLNQFE 118
+P +L+K FGAE+V T+ +K E +K A L QF+
Sbjct: 194 LILTMPASMSMERRVLLKAFGAELVLTDPAKGMTGAVQKAEEILK---NTPDAYMLQQFD 250
Query: 119 NDANFEAHYYGTARELEEQLRSIDKIPEIIIAGIGTSGHIAGISKYFKERY-ETKIIGVV 177
N AN + HY T E+ + + K+ +I +AGIGT G I G+ ++ KE+ +T++IGV
Sbjct: 251 NPANPKIHYETTGPEIWDDTKG--KV-DIFVAGIGTGGTITGVGRFIKEKNPKTQVIGVR 307
Query: 178 PAKGETI----PGIKRLETRPKWFFKVEVDE-------VVEVTAREAFEGILKVARSDGL 226
P + + + PG +++ F +D+ + ++ EA E ++A +GL
Sbjct: 308 PTESDILSGGKPGPHKIQGIGAGFIPKNLDQKIMDEVIAISISKLEAIETAKQLALKEGL 367
Query: 227 LIGMSSGAVVKAYEKV-RPEGTTVLI---FPDDG 256
++G+SSGA A + RPE LI FP G
Sbjct: 368 MVGISSGAAAAAIKVAKRPENAGKLIAVVFPSFG 401
>pir||S49586 cysteine synthase (EC 4.2.99.8) ACS1 - Arabidopsis thaliana
>gi|572519|emb|CAA57343.1| (X81697) cysteine synthase
[Arabidopsis thaliana]
Length = 324
Score = 109 bits (269), Expect = 5e-23
Identities = 92/273 (33%), Positives = 135/273 (48%), Gaps = 20/273 (7%)
Query: 4 AKLEFFNPFSR-SIKDRAVYNMLIKALRSGEI-DGTNVLYEATSGNVG-ISIAALSAVFG 60
AKLE P S S+KDR ++M+ A + G I G +VL E TSGN G + +A +A G
Sbjct: 35 AKLEMMEPCSSVSVKDRIGFSMISDAEKKGLIKQGESVLIEPTSGNTGELLLAFTAACKG 94
Query: 61 LKFRAYIPKPTPKTTELLIKVFGAEVVRTN-FDTIDKKFVEFVKLEARRDKALNLNQFEN 119
K +P +++ FG EVV T+ + + + ++ A+ L QFEN
Sbjct: 95 YKLIITMPASMSTERRIILLAFGVEVVLTDPAKGMKGSYRKAQEILAKTPNGYMLQQFEN 154
Query: 120 DANFEAHYYGTARELEEQLRSIDKIPEIIIAGIGTSGHIAGISKYFKERYET-KIIGVVP 178
AN E HY T E+ + + KI + ++GIGT G I G KY KE+ K+ GV P
Sbjct: 155 PANPEIHYEPTGPEIWKGTGA--KI-DGFVSGIGTGGTITGAGKYLKEQNPNFKLYGVEP 211
Query: 179 AKGETIPGIKRLETR---------PKWFFKVEVDEVVEVTAREAFEGILKVARSDGLLIG 229
+ + G K T+ P +DEVV+V++ E+ + ++A +GLL+G
Sbjct: 212 VESAILSGGKPGPTKIQGIGAGFIPSVLNVDLIDEVVQVSSDESIDMARQLALKEGLLVG 271
Query: 230 MSSGAVVKAYEKVRPEGT---TVLIFPDDGFKY 259
+SSGA RPE V IFP G +Y
Sbjct: 272 ISSGAAAAIKLAQRPENAGKLFVAIFPSFGRRY 304
>sp|O22682|CYSN_ARATH PROBABLE CYSTEINE SYNTHASE, CHLOROPLAST PRECURSOR (O-ACETYLSERINE
SULFHYDRYLASE) (O-ACETYLSERINE (THIOL)-LYASE) (CSASE)
(OAS-TL) (CS26) >gi|2281780|dbj|BAA21628.1| (AB003041)
O-acetylserine (thiol) lyase [Arabidopsis thaliana]
>gi|6091759|gb|AAF03469.1|AC009327_8 (AC009327)
O-acetylserine (thiol) lyase [Arabidopsis thaliana]
Length = 404
Score = 108 bits (268), Expect = 6e-23
Identities = 90/265 (33%), Positives = 133/265 (49%), Gaps = 15/265 (5%)
Query: 4 AKLEFFNPFSRSIKDRAVYNMLIKALRSGEIDGTN-VLYEATSGNVGISIAALSAVFGLK 62
AKLE P RS+KDR +M+ +A SG I VL E T+GN G+ IA ++A G K
Sbjct: 128 AKLESMEP-CRSVKDRIGLSMINEAENSGAITPRKTVLVEPTTGNTGLGIAFVAAAKGYK 186
Query: 63 FRAYIPKPTPKTTELLIKVFGAEVVRTNFDTIDKKFVEFVK-LEARRDKALNLNQFENDA 121
+P +L++ GAE+V TN + K V+ K + + A QF+N A
Sbjct: 187 LIVTMPASINIERRMLLRALGAEIVLTNPEKGLKGAVDKAKEIVLKTKNAYMFQQFDNTA 246
Query: 122 NFEAHYYGTAREL-EEQLRSIDKIPEIIIAGIGTSGHIAGISKYFK-ERYETKIIGVVPA 179
N + H+ T E+ E+ + ++D I +AGIGT G + G + K + K++GV P+
Sbjct: 247 NTKIHFETTGPEIWEDTMGNVD----IFVAGIGTGGTVTGTGGFLKMMNKDIKVVGVEPS 302
Query: 180 KGETIPGIKRLETRPKWFFKVEVDEVVEVTAREAFEGILKVARSDGLLIGMSSGAVVKAY 239
+ I G P +DEV +V+ EA E ++A +GLL+G+SSGA A
Sbjct: 303 ERSVISG-DNPGYLPGILDVKLLDEVFKVSNGEAIEMARRLALEEGLLVGISSGAAAVAA 361
Query: 240 EKV--RPEGTTVLI---FPDDGFKY 259
+ R E LI FP G +Y
Sbjct: 362 VSLAKRAENAGKLITVLFPSHGERY 386
>emb|CAC12819.1| (AJ299249) cysteine synthase [Nicotiana tabacum]
Length = 324
Score = 108 bits (268), Expect = 6e-23
Identities = 95/279 (34%), Positives = 136/279 (48%), Gaps = 33/279 (11%)
Query: 4 AKLEFFNPFSRSIKDRAVYNMLIKALRSGEID-GTNVLYEATSGNVGISIAALSAVFGLK 62
AKLE P S S+KDR Y+M+ A G I G VL E TSGN GI +A ++A G K
Sbjct: 36 AKLESMEPCS-SVKDRMAYSMIKDAEDKGLITPGKTVLLEVTSGNTGIGLAFIAAARGYK 94
Query: 63 FRAYIPKPTPKTTELLIKVFGAEVVRTN-FDTIDKKFVEFVKLEARRDKALNLNQFENDA 121
+P +++K G+E+ T+ ID + ++ R QFEN A
Sbjct: 95 LVTVMPASYSLERRIVLKALGSELYITDPAKGIDGVLQKAEEILDRTPNCHFFRQFENPA 154
Query: 122 NFEAHYYGTARELEEQLRSIDKIPEIIIAGIGTSGHIAGISKYFKERY-ETKIIGVVPAK 180
N + HY T E+ + KI +I IAGIGT G + G ++ KE+ E K+ G+ PA+
Sbjct: 155 NPKIHYETTGPEIWKCTGG--KI-DIFIAGIGTGGTVTGAGRFLKEKNPEIKVYGMEPAR 211
Query: 181 GETIPGIKRLETRPKWFFKVE---------------VDEVVEVTAREAFEGILKVARSDG 225
E R K K++ +DEV++V++ EA E +A +G
Sbjct: 212 K------CNSEWRTKGPHKIQGIGAGFVPVVLDLSILDEVLQVSSDEAIEMTKLLALKEG 265
Query: 226 LLIGMSSGAVVKAYEKV--RPEGT---TVLIFPDDGFKY 259
LL+G+SSGA A KV +PE +IFP G +Y
Sbjct: 266 LLVGISSGAAAAAAIKVAKKPENAGKLIAVIFPSFGERY 304
>pir||H69973 cysteine synthase (EC 4.2.99.8) yrhA [similarity] - Bacillus
subtilis >gi|1934605|gb|AAB80858.1| (U93874) cysteine
synthase [Bacillus subtilis] >gi|2635172|emb|CAB14668.1|
(Z99117) similar to cysteine synthase [Bacillus
subtilis]
Length = 307
Score = 107 bits (264), Expect = 2e-22
Identities = 80/271 (29%), Positives = 130/271 (47%), Gaps = 18/271 (6%)
Query: 3 FAKLEFFNPFSRSIKDRAVYNMLIKALRSGEIDGTNVLYEATSGNVGISIAALSAVFGLK 62
+AKLE NP SIKDR ++ AL SG++ V+ EAT+GN GI +A + +GLK
Sbjct: 31 YAKLEMMNP-GGSIKDRLGDMLIRDALDSGKVKPGGVIIEATAGNTGIGLALSARKYGLK 89
Query: 63 FRAYIPKPTPKTTELLIKVFGAEVVRT-NFDTIDKKFVEFVKLEARRDKALNLNQFENDA 121
+P+ + + +++ GA ++ T D + + ++LE + + + QF+N
Sbjct: 90 AIFCVPEHFSREKQQIMQALGASIIHTPRQDGMQGAIQKAIQLETEIENSYCVLQFKNRV 149
Query: 122 NFEAHYYGTARELEEQLRSIDKIPEIIIAGIGTSGHIAGISKYFKERYETKIIGVVPAKG 181
N +Y E+ E ++D +AG G+ G AG + + KE+ +V G
Sbjct: 150 NPSTYYKTLGPEMWE---ALDGNIHTFVAGAGSGGTFAGTASFLKEKNPAVKTVIVEPVG 206
Query: 182 ETIPGIK---------RLETRPKWFFKVEVDEVVEVTAREAFEGILKVARSDGLLIGMSS 232
+ G + +E P + K DE+ VT AF + + A +GLLIG SS
Sbjct: 207 SILNGGEPHAHKTEGIGMEFIPDYMDKSHFDEIYTVTDENAFRLVKEAAEKEGLLIGSSS 266
Query: 233 GAVVKA---YEKVRPEGTTVL-IFPDDGFKY 259
GA + A K GT ++ +FPD +Y
Sbjct: 267 GAALYAALEEAKKASAGTNIVTVFPDSSDRY 297
>gb|AAD56585.2|AF186381_1 (AF186381) cysteine synthase [Bacillus thermoleovorans]
Length = 299
Score = 107 bits (264), Expect = 2e-22
Identities = 91/271 (33%), Positives = 135/271 (49%), Gaps = 20/271 (7%)
Query: 3 FAKLEFFNPFSRSIKDRAVYNMLIKALRSGEIDGTNVLYEATSGNVGISIAALSAVFGLK 62
+ KLEF NP S S+KDR M+ A ++G++ + + E TSGN GI +A ++A G K
Sbjct: 32 YLKLEFMNPGS-SVKDRIALAMIEAAEKAGKLKPGDTIVEPTSGNTGIGLAMVAAAKGYK 90
Query: 63 FRAYIPKPTPKTTELLIKVFGAEVVRTNFDTIDKKFVEFVKLEARRDKALNLNQFENDAN 122
+P L++ +GAE+V T + + + E R+ A + Q AN
Sbjct: 91 AVLVMPDTMSLERRNLLRAYGAELVLTPGAQGMRGAIRKAE-ELVREHAYFIPQHLKRAN 149
Query: 123 FEAHYYGTARELEEQLRSIDKIPEIIIAGIGTSGHIAGISKYFKERY-ETKIIGVVPAKG 181
E H T +E+ EQ+ D++ + +AG+GT G I G K +E Y KI V PA
Sbjct: 150 PEIHRLTTGKEIVEQMG--DQL-DAFVAGVGTGGTITGAGKVLREAYPNIKIYAVEPADS 206
Query: 182 ETI----PGIKRLETRPKWFFKVEVDE-----VVEVTAREAFEGILKVARSDGLLIGMSS 232
+ PG +++ F +D V+ VT EAF G + AR +G+L G+SS
Sbjct: 207 PVLSGGKPGPHKIQGIGAGFVPDILDTSIYDGVITVTTEEAFRG-PRAAREEGILGGISS 265
Query: 233 GAVVKAYEKVRPE---GTTVL-IFPDDGFKY 259
GA + A KV E G VL I P +G +Y
Sbjct: 266 GAAIHAALKVAKELGKGKKVLAIIPSNGERY 296
>pir||A55450 cysteine synthase (EC 4.2.99.8) C precursor, mitochondrial -
spinach >gi|1066153|dbj|BAA07177.1| (D37963) cysteine
synthase [Spinacia oleracea]
Length = 368
Score = 105 bits (260), Expect = 5e-22
Identities = 97/290 (33%), Positives = 148/290 (50%), Gaps = 31/290 (10%)
Query: 5 KLEFFNPFSRSIKDRAVYNMLIKALRSGEID-GTNVLYEATSGNVGISIAALSAVFGLKF 63
K E P + S+KDR M+ A + G I G VL E TSGN+GIS+A ++A+ G K
Sbjct: 79 KQEMMQP-TASVKDRPALAMIEDAEKKGLISPGKTVLIEPTSGNMGISMAFMAAMKGYKM 137
Query: 64 RAYIPKPTPKTTELLIKVFGAEVVRTNFDTIDKKFVEFVK-----LEARRDKALNLNQFE 118
+P T ++++ FGA+++ T+ DK VK L++ D L QF
Sbjct: 138 VLTMPSYTSMERRVVMRAFGADLILTD---PDKGMGGTVKKANQLLDSTPD-GFMLQQFN 193
Query: 119 NDANFEAHYYGTARELEEQLRSIDKIPEIIIAGIGTSGHIAGISKYFK-ERYETKIIGVV 177
N AN + H+ T E+ E + K+ +I + GIG+ G ++G+ +Y K + KI GV
Sbjct: 194 NPANTQVHFETTGPEIWEDTQG--KV-DIFVMGIGSGGTVSGVGRYLKSQNPNVKIYGVE 250
Query: 178 PAKGETIPGIK---RLETRPKWFFKVEV------DEVVEVTAREAFEGILKVARSDGLLI 228
PA+ + G K L T FK E+ D V+EV + +A + ++A +GLL+
Sbjct: 251 PAESNILNGGKPGPHLITGNGVGFKPEILDMDVMDAVLEVKSDDAVKMARQLALQEGLLV 310
Query: 229 GMSSGA-VVKAYEKV-RPEG---TTVLIFPDDGFKY--GEIFEMLLGEAQ 271
G+SSGA + A + RPE V I P G +Y +F+ L EA+
Sbjct: 311 GISSGANTIAALDLAKRPENKGKLIVTIHPSFGERYLSSALFKELREEAE 360
>emb|CAA06819.1| (AJ006024) cysteine synthase, O-acetyl-L-serine (thiol)-lyase
[Cicer arietinum]
Length = 266
Score = 105 bits (260), Expect = 5e-22
Identities = 82/254 (32%), Positives = 130/254 (50%), Gaps = 21/254 (8%)
Query: 36 GTNVLYEATSGNVGISIAALSAVFGLKFRAYIPKPTPKTTELLIKVFGAEVVRTNFDTID 95
G +VL E TSGN GI +A ++A G K +P +++ FGAE+V T+
Sbjct: 10 GQSVLIEPTSGNTGIGLAFMAAAKGYKLIITMPASMSLERRIILLAFGAELVLTDPAKGM 69
Query: 96 KKFVEFV-KLEARRDKALNLNQFENDANFEAHYYGTARELEEQLRSIDKIPEIIIAGIGT 154
K V+ ++ A+ A L QFEN AN + HY T E+ + + + ++GIGT
Sbjct: 70 KGAVQKAEEILAKTPNAYILQQFENPANPKVHYETTGPEI---WKGTEGKVDAFVSGIGT 126
Query: 155 SGHIAGISKYFKERY-ETKIIGVVPAKGETI----PGIKRLETRPKWF----FKVE-VDE 204
G I G KY KE+ K++GV P + + PG +++ F +V +DE
Sbjct: 127 GGTITGAGKYLKEQNPNIKLVGVEPVESPVLSGGKPGPHKIQGIGAGFVPGVLEVNLIDE 186
Query: 205 VVEVTAREAFEGILKVARSDGLLIGMSSGAVVKAYEKV--RPEGT---TVLIFPDDGFKY 259
V+++++ EA E +A +GL +G+SSGA A K+ RPE V++FP G +Y
Sbjct: 187 VIQISSDEAIETAKLLALKEGLFVGISSGAAAAAAIKIAKRPENAGKLIVVVFPSFGERY 246
Query: 260 --GEIFEMLLGEAQ 271
+FE + +A+
Sbjct: 247 LSSVLFESVRRQAE 260
>sp|P47998|CYSK_ARATH CYSTEINE SYNTHASE (O-ACETYLSERINE SULFHYDRYLASE) (O-ACETYLSERINE
(THIOL)-LYASE) (CSASE) >gi|1084346|pir||S48694 cysteine
synthase (EC 4.2.99.8) isoform 5-8, cytosolic -
Arabidopsis thaliana
Length = 315
Score = 104 bits (258), Expect = 9e-22
Identities = 94/287 (32%), Positives = 140/287 (48%), Gaps = 26/287 (9%)
Query: 4 AKLEFFNPFSRSIKDRAVYNMLIKALRSGEID-GTNVLYEATSGNVGISIAALSAVFGLK 62
AKLE P S S+KDR ++M+ A + G I G +VL E TSGN G+ IA +A G K
Sbjct: 34 AKLEMMEPCS-SVKDRIGFSMISDAEKKGLIKPGESVLIEPTSGNTGVGIAFTAAAKGYK 92
Query: 63 FRAYIPKPTPKTTELLIKVFGAEVVRTN-FDTIDKKFVEFVKLEARRDKALNLNQFENDA 121
+P +++ FG E+V T+ + + ++ A+ L QFEN A
Sbjct: 93 LIITMPASMSTERRIILLAFGVELVLTDPAKGMKGAIAKAEEILAKTPNGYMLQQFENPA 152
Query: 122 NFEAHYYGTARELEEQLRSIDKIPEIIIAGIGTSGHIAGISKYFKER-YETKIIGVVPAK 180
N + HY T E+ + + DKI +I ++GIGT I G K R K+ GV P +
Sbjct: 153 NPKIHYETTGPEIWK--GTGDKI-DIFVSGIGTG--ITGAGSILKNRTANVKLYGVEPVE 207
Query: 181 GETI----PGIKRLETRPKWFFKVE-----VDEVVEVTAREAFEGILKVARSDGLLIGMS 231
+ PG +++ F +DEVV+V++ E+ + ++A +G L+G+S
Sbjct: 208 SAILIGGKPGPHKIQGIGAGFIPSVLNVDLIDEVVQVSSDESIDMARQLALKEGFLVGIS 267
Query: 232 SGAVVKAYEKV--RPEGT---TVLIFPDDGFKYGEIFEMLLGEAQGK 273
SGA A K+ RPE V IFP G +Y +L QGK
Sbjct: 268 SGAAAAAAIKLAQRPENAGKLFVAIFPSFGERY---LSTVLSMRQGK 311
>sp|P56067|CYSM_HELPY CYSTEINE SYNTHASE (O-ACETYLSERINE SULFHYDRYLASE) (O-ACETYLSERINE
(THIOL)-LYASE) (CSASE) >gi|7436933|pir||C64533 cysteine
synthase (EC 4.2.99.8) HP0107 [similarity] -
Helicobacter pylori (strain 26695)
>gi|2313190|gb|AAD07177.1| (AE000532) cysteine
synthetase (cysK) [Helicobacter pylori 26695]
Length = 306
Score = 104 bits (258), Expect = 9e-22
Identities = 89/275 (32%), Positives = 136/275 (49%), Gaps = 26/275 (9%)
Query: 3 FAKLEFFNPFSRSIKDRAVYNMLIKALRSGEIDGTNVLYEATSGNVGISIAALSAVFGLK 62
+AKLE NP S+KDR ++ + ++G+I + E T+GN GI++A ++ LK
Sbjct: 33 YAKLEHLNP-GGSVKDRLGQYLIGEGFKTGKITSKTTIIEPTAGNTGIALALVAIKHHLK 91
Query: 63 FRAYIPKPTPKTTELLIKVFGAEVVRT----NFDTIDKKFVEFVKLEARRDKALNLNQFE 118
+P+ + +++ GA V+ T KK E E+ D L L QFE
Sbjct: 92 TIFVVPEKFSTEKQQIMRALGALVINTPTSEGISGAIKKSKELA--ESIPDSYLPL-QFE 148
Query: 119 NDANFEAHYYGTARELEEQLRSIDKIPEIIIAGIGTSGHIAGISKYFKERYET-KIIGVV 177
N N A+Y+ A E+ ++L + +AGIG+ G AG ++Y KER ++IGV
Sbjct: 149 NPDNPAAYYHTLAPEIVQELGT---NLTSFVAGIGSGGTFAGTARYLKERIPAIRLIGVE 205
Query: 178 PAKG---------ETIPGIKRLETRPKWFFKVEVDEVVEVTAREAFEGILKVARSDGLLI 228
P I GI +E P +F +++D ++ E F K+A+ +GLL+
Sbjct: 206 PEGSILNGGEPGPHEIEGI-GVEFIPPFFENLDIDGFETISDEEGFSYTRKLAKKNGLLV 264
Query: 229 GMSSGAVVKAYEKVR---PEGTTVL-IFPDDGFKY 259
G SSGA A K PEG+ VL IFPD +Y
Sbjct: 265 GSSSGAAFVAALKEAQRLPEGSQVLTIFPDVADRY 299
>pir||T09000 cysteine synthase (EC 4.2.99.8) - spinach chloroplast
>gi|464226|gb|AAA16973.1| (L05184)
O-acetylserine-(thiol)-lyase [Spinacia oleracea]
Length = 390
Score = 104 bits (256), Expect = 2e-21
Identities = 92/279 (32%), Positives = 137/279 (48%), Gaps = 27/279 (9%)
Query: 4 AKLEFFNPFSRSIKDRAVYNMLIKALRSGEID-GTNVLYEATSGNVGISIAALSAVFGLK 62
AKLE P S+KDR Y+M+ A + G I G L E TSGN GI +A ++A G K
Sbjct: 96 AKLESMEPCC-SVKDRIGYSMIDDAEQKGVITPGKTTLVEPTSGNTGIGLAFIAAARGYK 154
Query: 63 FRAYIPKPTPKTTE------LLIKVFGAEVVRTNFDTIDKKFVEFVK-LEARRDKALNLN 115
+P E +++K FGAE+V T+ K VE + + + + L
Sbjct: 155 ITLTMPASMSMEKESYLERRVILKAFGAELVLTDPAKGMKGAVEKAEEILKKTPDSYMLQ 214
Query: 116 QFENDANFEAHYYGTARELEEQLRSIDKIPEIIIAGIGTSGHIAGISKYFKERYE-TKII 174
QF+N AN + HY T E+ E + K+ +I +AGIGT G I+G+ K ++I
Sbjct: 215 QFDNPANPKIHYETTGPEIWEDTKG--KV-DIFVAGIGTGGTISGVDGTSKNANPGVQVI 271
Query: 175 GVVPAKGETI----PGIKRLETRPKWFFKVEVD-----EVVEVTAREAFEGILKVARSDG 225
G+ P + G +++ F +D EV+EV++ EA E ++A +G
Sbjct: 272 GIEPTESNYFLVESAGPHKIQGLGAGFVPSNLDLGVMDEVIEVSSEEAVEMAKQLAMKEG 331
Query: 226 LLIGMSSGAVVKAYEKV--RPEGTTVLI---FPDDGFKY 259
LL+G+SSG A ++ RPE LI FP G +Y
Sbjct: 332 LLVGISSGRGAAAAVRIGKRPENAGKLIAVVFPSFGERY 370
>gb|AAD23908.1|AF073696_1 (AF073696) cysteine synthase [Oryza sativa]
Length = 357
Score = 103 bits (255), Expect = 2e-21
Identities = 84/275 (30%), Positives = 139/275 (50%), Gaps = 27/275 (9%)
Query: 5 KLEFFNPFSRSIKDRAVYNMLIKALRSGEID-GTNVLYEATSGNVGISIAALSAVFGLKF 63
K+E + P S+KDR+ M+ A G I G L E TSGN+GI + ++ G +F
Sbjct: 72 KMEAYQPLC-SVKDRSALRMIEDAEEKGLITPGVTTLIEPTSGNLGIGLVLVAVQKGYRF 130
Query: 64 RAYIPKPTPKTTELLIKVFGAEVVRTN----FDTIDKKFVEFVKLEARRDKALNLNQFEN 119
A +P ++L++ GAE++ T+ F+ + K E +K + LNQ N
Sbjct: 131 IAVMPAKYSLDKQMLLRFLGAELILTDPAIGFNGMMDKVEELMK---SIPNSHCLNQVTN 187
Query: 120 DANFEAHYYGTARELEEQLRSIDKIPEIIIAGIGTSGHIAGISKYFKERYET-KIIGVVP 178
AN EAH+ T E+ + + K+ ++ +A +G+ G + G+ +Y K + + I+ V P
Sbjct: 188 PANPEAHFMWTGPEIWKD--TAGKV-DVFVASVGSGGTLTGVGRYLKMKNPSINIVCVEP 244
Query: 179 AKGETI----PGIKRLETR-----PKWFFKVEVDEVVEVTAREAFEGILKVARSDGLLIG 229
++ I PG +++ P+ K +DEVV V E+ ++A+ +GLL+G
Sbjct: 245 SESPVISGGSPGPHKIQGTGAGFIPEILDKSVIDEVVTVNTEESMAMARRLAKEEGLLVG 304
Query: 230 MSSGAVVKAYEKV--RPEG---TTVLIFPDDGFKY 259
+SSGA V A K+ R E V +FP G +Y
Sbjct: 305 ISSGANVAACIKIADREENKGKMIVTMFPSGGERY 339
>pir||F72594 cystathionine beta-synthase (EC 4.2.1.22) APE1223 [similarity] -
Aeropyrum pernix (strain K1) >gi|5104898|dbj|BAA80212.1|
(AP000061) 393aa long hypothetical cystathionine
beta-synthase [Aeropyrum pernix]
Length = 393
Score = 102 bits (253), Expect = 4e-21
Identities = 96/330 (29%), Positives = 139/330 (42%), Gaps = 80/330 (24%)
Query: 3 FAKLEFFNPFSRSIKDRAVYNMLIKALRSGEIDGTNVLYEATSGNVGISIAALSAVFGLK 62
+ KLE FNP S+KDR ML+ A G ++ V+ E T+GN G+ +A + +G +
Sbjct: 44 YGKLEMFNP-GGSVKDRIGLYMLMDARSRGLVEEGAVIIEPTAGNTGVGLALAAIHYGFR 102
Query: 63 FRAYIPKPTPKTTELLIKVFGAEVVRTNFDTID--------------------------- 95
A +P EL+++ +GA V+RT
Sbjct: 103 LVAVMPSKMSVEKELILRAYGAYVIRTPTAVPPESPLSYYRVAEAVRNLLWMIGGRPGGG 162
Query: 96 --KKFVEFVKLEARRDKALNL-----------------NQFENDANFEAHYYGTARELEE 136
+K VE V+ R ++ +L NQ+ N AN AH T RE+
Sbjct: 163 EVRKVVEKVQTLVREERVEDLRSILEASVEPTPYAYIPNQYSNPANPRAHEETTGREIWM 222
Query: 137 QLRSIDKIPEIIIAGIGTSGHIAGISKYFKE-RYETKIIGVVP-------AKGETIPGIK 188
Q +++ AG+GT G I G+++Y K + +I+GV P K P
Sbjct: 223 QTGGR---VDVVYAGMGTRGTITGVARYLKRAKPSVRIVGVDPEGSIYSLVKKGMSPHEA 279
Query: 189 RLETRPKWFFKVE---------------VDEVVEVTAREAFEGILKVARSDGLLIGMSSG 233
RP +KVE VDEVV VT ++AF +AR +G+L G SSG
Sbjct: 280 AKHARP---YKVEGIGEDFIPSTIDLSLVDEVVVVTDQQAFSMARMLARLEGVLAGGSSG 336
Query: 234 ----AVVKAYEKVRPEGTTVLIFPDDGFKY 259
A VK + R G V+I PD G Y
Sbjct: 337 AALYAAVKHIKTRRVRGVAVVILPDTGRNY 366
>sp|P46794|CBS_DICDI CYSTATHIONINE BETA-SYNTHASE (SERINE SULFHYDRASE) (BETA-THIONASE)
>gi|881420|gb|AAA70099.1| (U27536) cystathionine beta
synthase [Dictyostelium discoideum]
Length = 497
Score = 102 bits (253), Expect = 4e-21
Identities = 80/252 (31%), Positives = 122/252 (47%), Gaps = 24/252 (9%)
Query: 4 AKLEFFNPFSRSIKDRAVYNMLIKALRSGEIDGTNVLYEATSGNVGISIAALSAVFGLKF 63
AK EFFN S+KDR + M++ A SG I + L E TSGN GI +A +A+ G K
Sbjct: 61 AKCEFFNA-GGSVKDRIGHRMIVDAEESGRIKKGDTLIEPTSGNTGIGLALTAAIKGYKM 119
Query: 64 RAYIPKPTPKTTELLIKVFGAEVVRT----NFDTIDKKFVEFVKLEARRDKALNLNQFEN 119
+P+ + ++K G E++RT FD + KL + + L+Q+ N
Sbjct: 120 IITLPEKMSQEKVDVLKALGGEIIRTPTEAAFDAPESHIGVAKKLNSEIPNSHILDQYGN 179
Query: 120 DANFEAHYYGTARELEEQLRSIDKIPEIIIAGIGTSGHIAGISKYFKERYETKIIGVVPA 179
+N AHY GTA EL EQ KI ++I+ GT G I GI++ KER I+ V
Sbjct: 180 PSNPLAHYDGTAEELLEQCEG--KI-DMIVCTAGTGGTITGIARKIKERLPNCIVVGVDP 236
Query: 180 KGETIPGIKRLETRPKWFFKVE---------------VDEVVEVTAREAFEGILKVARSD 224
G + + L K +K+E VD+ ++ +E+F ++ + +
Sbjct: 237 HGSILAQPESLNNTNK-SYKIEGIGYDFIPNVLERKLVDQWIKTDDKESFIMARRLIKEE 295
Query: 225 GLLIGMSSGAVV 236
GLL SSG+ +
Sbjct: 296 GLLCAGSSGSAM 307
>gb|AAG19647.1| (AE005053) cysteine synthase; CysK [Halobacterium sp. NRC-1]
Length = 327
Score = 102 bits (253), Expect = 4e-21
Identities = 83/249 (33%), Positives = 121/249 (48%), Gaps = 23/249 (9%)
Query: 4 AKLEFFNPFSRSIKDRAVYNMLIKALRSGEIDGTNVLYEATSGNVGISIAALSAVFGLKF 63
AKLE FNP + S KDR M++ A R+GEI + L EATSGN GI +A +A G
Sbjct: 26 AKLEGFNP-AGSAKDRPAREMVLAAERAGEIQPGDQLVEATSGNTGIGLALTAAARGYDL 84
Query: 64 RAYIPKPTPKTTELLIKVFGA--EVVRTNFDTIDKKFVEFVKLEARRDKALNLNQFENDA 121
+P + L++ +GA E+V +T + + A A + QFEN A
Sbjct: 85 TIVMPASMSTERKQLLRAYGADLELVDAGMETAN----QVADRVAADTGAFRVGQFENPA 140
Query: 122 NFEAHYYGTARELEEQL--RSIDKIPEIIIAGIGTSGHIAGISKYFKERY-ETKIIGVVP 178
N AHY TA E+ +Q+ R ID ++AG+GT G I G + +E + E ++ V P
Sbjct: 141 NPRAHYRTTAEEILDQVEGREID----ALVAGVGTGGTITGTATRLREAHPEMSVVAVEP 196
Query: 179 AKGETI----PGIKRLETRPKWFFKVEVD----EVVEVTAREAFEG-ILKVARSDGLLIG 229
+ G + F +D + VE A +A E ++AR +G+L+G
Sbjct: 197 EANAVLSTGESGDDDFQGMGPGFVSDNLDRELIDTVETVAVDAAEAETRRLAREEGVLVG 256
Query: 230 MSSGAVVKA 238
SSGA A
Sbjct: 257 QSSGAAALA 265
>pir||A75477 cysteine synthase (EC 4.2.99.8) DR0789 [similarity] - Deinococcus
radiodurans (strain R1)
>gi|6458500|gb|AAF10366.1|AE001933_10 (AE001933)
O-acetylserine (thiol)-lyase [Deinococcus radiodurans]
Length = 317
Score = 102 bits (251), Expect = 6e-21
Identities = 79/271 (29%), Positives = 128/271 (47%), Gaps = 18/271 (6%)
Query: 3 FAKLEFFNPFSRSIKDRAVYNMLIKALRSGEIDGTNVLYEATSGNVGISIAALSAVFGLK 62
F KLE NP SIKDR ++ A R G + + E TSGN GI +A ++A G K
Sbjct: 26 FIKLEGQNP-GGSIKDRTALGLVQDAERRGVLKPGGTIVEPTSGNTGIGLAQVAAAKGYK 84
Query: 63 FRAYIPKPTPKTTELLIKVFGAEVVRTNFDTIDKKFVEFVKLEARRDKALNLNQFENDAN 122
+P + + ++ +GAE++ T+ + +E + A A+ +NQF N AN
Sbjct: 85 LILCMPAQMSEERKRTLRAYGAELILTDPERRMLAAIEEAEKIAAETGAVMMNQFANPAN 144
Query: 123 FEAHYYGTARELEEQLRSIDKIPEIIIAGIGTSGHIAGISKYFKER-YETKIIGVVPAKG 181
H T EL EQ+ + + + G GT G I G +Y K + ++I PA+
Sbjct: 145 PATHEASTGPELWEQM---EGRVDAFVYGTGTGGTITGTGRYLKRQDPNIQVIACEPARS 201
Query: 182 ETIPGIKRLETR---------PKWFFKVEVDEVVEVTAREAFEGILKVARSDGLLIGMSS 232
+ G +R P + +D+V++V +A+ ++A+ +G+ IGMSS
Sbjct: 202 NVLSGGERGNHGFQGMGPGFIPDNLDRSLLDDVIQVWEEDAYPLARRLAQEEGIFIGMSS 261
Query: 233 GAVV----KAYEKVRPEGTTVLIFPDDGFKY 259
GA+V + ++ P V I D G +Y
Sbjct: 262 GAMVWTALEVARRLGPGKRVVTIACDTGARY 292
>dbj|BAB18760.1| (AB027000) beta-cyanoalanine synthase [Solanum tuberosum]
Length = 351
Score = 101 bits (250), Expect = 8e-21
Identities = 90/290 (31%), Positives = 141/290 (48%), Gaps = 31/290 (10%)
Query: 5 KLEFFNPFSRSIKDRAVYNMLIKALRSGEID-GTNVLYEATSGNVGISIAALSAVFGLKF 63
K E P S SIKDR + M+ A + G I G L E TSGN+GIS+A ++A+ G K
Sbjct: 62 KQEMMQPTS-SIKDRPAFAMINDAEKKGLITPGKTTLIEPTSGNMGISMAFMAAMKGYKM 120
Query: 64 RAYIPKPTPKTTELLIKVFGAEVVRTN-----FDTIDKKFVEFVKLEARRDKALNLNQFE 118
+P T + ++ FGA++V T+ TI K + L A L QF
Sbjct: 121 ILTMPSYTSLERRVTMRAFGADLVTTDPTKGMGGTIKKAY----DLLESTPNAYMLQQFS 176
Query: 119 NDANFEAHYYGTARELEEQLRSIDKIPEIIIAGIGTSGHIAGISKYFKERY-ETKIIGVV 177
N AN +AH+ T E+ E + +I + GIG+ G ++G+ +Y K + KI G+
Sbjct: 177 NPANTQAHFETTGPEIWEDTQG---NVDIFVMGIGSGGTVSGVGQYLKSKNPNVKIYGIE 233
Query: 178 PAKGETI----PGIKRLE-----TRPKWFFKVEVDEVVEVTAREAFEGILKVARSDGLLI 228
P + + PG + +P ++EV+ V++ E+ ++A +GL++
Sbjct: 234 PTESNVLNGGNPGPHEITGNGVGFKPDILDMDVMEEVLMVSSEESVNMARELALKEGLMV 293
Query: 229 GMSSGAVVKAYEKV--RPEG---TTVLIFPDDGFKY--GEIFEMLLGEAQ 271
G+SSGA A ++ RPE V I P G +Y ++E + EAQ
Sbjct: 294 GISSGANTVAALRLANRPENKGKLIVTIHPSFGERYLSSVLYEDIRKEAQ 343
>emb|CAB89449.1| (AL354048) putative cystathionine beta-synthase [Streptomyces
coelicolor A3(2)]
Length = 461
Score = 101 bits (249), Expect = 1e-20
Identities = 82/274 (29%), Positives = 131/274 (46%), Gaps = 22/274 (8%)
Query: 4 AKLEFFNPFSRSIKDRAVYNMLIKALRSGEIDGTNVLYEATSGNVGISIAALSAVFGLKF 63
AK+E+FNP S+KDR M+ A +SGE+ + E TSGN G+ +A ++ G K
Sbjct: 32 AKVEYFNP-GGSVKDRIALRMIEAAEKSGELQPGGTIVEPTSGNTGVGLAIVAQQKGYKC 90
Query: 64 RAYIPKPTPKTTELLIKVFGAEVV----RTNFDTIDKKFVEFVKLEARRDKALNLNQFEN 119
P +++ +GAEVV + + D + +L A +Q+ N
Sbjct: 91 IFVCPDKVSTDKINVLRAYGAEVVVCPTAVDPEHPDSYYNVSDRLVRETPGAWKPDQYSN 150
Query: 120 DANFEAHYYGTARELEEQLRSIDKIPEIIIAGIGTSGHIAGISKYFKERYE--TKIIGVV 177
N +HY+ T EL EQ KI +AG+GT G I+G +Y K+ + +IG
Sbjct: 151 PNNPLSHYHSTGPELWEQTEG--KITH-FVAGVGTGGTISGTGRYLKDASDGAVTVIGAD 207
Query: 178 PAKGETIPGIKR--------LETRPKWFFKVEVDEVVEVTAREAFEGILKVARSDGLLIG 229
P G R + P + + DE+V V+ +++F+ ++A+ +GLL+G
Sbjct: 208 PEGSVYSGGSGRPYLVEGVGEDFWPTAYDREVADEIVAVSDKDSFQMTRRLAKEEGLLVG 267
Query: 230 MSSG-AVVKAYE---KVRPEGTTVLIFPDDGFKY 259
S G AVV A E ++ + V++ PD G Y
Sbjct: 268 GSCGMAVVAALEVAARLGEDDVVVVLLPDSGRGY 301
>pir||S77347 cysteine synthase (EC 4.2.99.8) - Synechocystis sp. (strain PCC
6803) >gi|1652529|dbj|BAA17450.1| (D90906) cysteine
synthase [Synechocystis sp.]
Length = 331
Score = 101 bits (248), Expect = 1e-20
Identities = 84/272 (30%), Positives = 136/272 (49%), Gaps = 21/272 (7%)
Query: 5 KLEFFNPFSRSIKDRAVYNMLIKALRSGEID-GTNVLYEATSGNVGISIAALSAVFGLKF 63
KLE NP + S+KDR NM+ +A + G I+ G +L E TSGN GI++A ++A G +
Sbjct: 54 KLEGMNP-AASVKDRIGINMINRAEQEGLIEPGKTLLIEPTSGNTGIALAMVAAAKGYQL 112
Query: 64 RAYIPKPTPKTTELLIKVFGAEVVRT-NFDTIDKKFVEFVKLEARRDKALNLNQFENDAN 122
+P+ + ++K +GA++ T + + +L A L QF+N AN
Sbjct: 113 ILTMPETMSQERRAMLKAYGAKLELTPGSEGMGGCIRRAQELAESLPNAYMLQQFDNPAN 172
Query: 123 FEAHYYGTARELEEQLRSIDKIPEIIIAGIGTSGHIAGISKYFKERYET-KIIGVVPAKG 181
+ H TA E+ + D + ++AG+GT G I G++ KE+ + + I V P
Sbjct: 173 PQIHQQTTALEI---WQDTDGAIDFLVAGVGTGGTITGVASVLKEKKPSFQAIAVEPQNS 229
Query: 182 ETI----PGIKRLETRPKWFFKVE-----VDEVVEVTAREAFEGILKVARSDGLLIGMSS 232
+ PG +++ F +DEV+ VT EA ++AR +G+L G+S+
Sbjct: 230 PVLSGGKPGPHKIQGIGAGFIPEVLDVNLIDEVIAVTDEEAIAYGRRLAREEGILSGIST 289
Query: 233 GAVVKAYEKV--RP---EGTTVLIFPDDGFKY 259
GA + A KV RP + V+I P G +Y
Sbjct: 290 GAALAAAIKVAKRPANKDKLIVMIQPSFGERY 321
>dbj|BAA85110.1| (AB031003) O-acetylserine (thiol) lyase 1 [Cyanidioschyzon merolae]
Length = 389
Score = 101 bits (248), Expect = 1e-20
Identities = 89/272 (32%), Positives = 135/272 (48%), Gaps = 21/272 (7%)
Query: 5 KLEFFNPFSRSIKDRAVYNMLIKALRSGEID-GTNVLYEATSGNVGISIAALSAVFGLKF 63
KLE P S S+KDR M+++A + G+I G VL E TSGN GI++A L+A G +
Sbjct: 99 KLESMEPCS-SVKDRIGKYMIVEAEKRGDIQPGKTVLIEPTSGNTGIALAYLAAARGYRL 157
Query: 64 RAYIPKPTPKTTELLIKVFGAEVVRTNFDTIDKKFV-EFVKLEARRDKALNLNQFENDAN 122
+P ++++ FGAEVV T K V + +L A L QF N N
Sbjct: 158 ILTMPDSMSIERRMVLRAFGAEVVLTPAAKGMKGAVAKAEQLFHTTPNAYMLQQFNNPDN 217
Query: 123 FEAHYYGTARELEEQLRSIDKIPEIIIAGIGTSGHIAGISKYFKERY-ETKIIGVVPAKG 181
+AHY T E+ + + +AG+GT G + G +Y +E+ I+ V PA+
Sbjct: 218 PKAHYETTGPEI---WAATGGKVDAFVAGVGTGGTVTGAGRYLREQNPHVYIMAVEPAES 274
Query: 182 ETI----PGIKRLETRPKWFFKVEVD-----EVVEVTAREAFEGILKVARSDGLLIGMSS 232
+ PG +++ F +D EV +VT+ ++ E ++A +GLL G+SS
Sbjct: 275 PVLSGGRPGPHKIQGIGAGFVPGILDTKIYNEVKQVTSMDSIEMARRLAVEEGLLCGISS 334
Query: 233 GAVVKAYEKV--RPE---GTTVLIFPDDGFKY 259
GA V A ++ RPE V+I P G +Y
Sbjct: 335 GAAVVAALELGRRPEMKGKNIVVIIPSFGERY 366
>sp|P73410|CYSK_SYNY3 CYSTEINE SYNTHASE (O-ACETYLSERINE SULFHYDRYLASE) (O-ACETYLSERINE
(THIOL)-LYASE) (CSASE)
Length = 312
Score = 101 bits (248), Expect = 1e-20
Identities = 84/272 (30%), Positives = 136/272 (49%), Gaps = 21/272 (7%)
Query: 5 KLEFFNPFSRSIKDRAVYNMLIKALRSGEID-GTNVLYEATSGNVGISIAALSAVFGLKF 63
KLE NP + S+KDR NM+ +A + G I+ G +L E TSGN GI++A ++A G +
Sbjct: 35 KLEGMNP-AASVKDRIGINMINRAEQEGLIEPGKTLLIEPTSGNTGIALAMVAAAKGYQL 93
Query: 64 RAYIPKPTPKTTELLIKVFGAEVVRT-NFDTIDKKFVEFVKLEARRDKALNLNQFENDAN 122
+P+ + ++K +GA++ T + + +L A L QF+N AN
Sbjct: 94 ILTMPETMSQERRAMLKAYGAKLELTPGSEGMGGCIRRAQELAESLPNAYMLQQFDNPAN 153
Query: 123 FEAHYYGTARELEEQLRSIDKIPEIIIAGIGTSGHIAGISKYFKERYET-KIIGVVPAKG 181
+ H TA E+ + D + ++AG+GT G I G++ KE+ + + I V P
Sbjct: 154 PQIHQQTTALEI---WQDTDGAIDFLVAGVGTGGTITGVASVLKEKKPSFQAIAVEPQNS 210
Query: 182 ETI----PGIKRLETRPKWFFKVE-----VDEVVEVTAREAFEGILKVARSDGLLIGMSS 232
+ PG +++ F +DEV+ VT EA ++AR +G+L G+S+
Sbjct: 211 PVLSGGKPGPHKIQGIGAGFIPEVLDVNLIDEVIAVTDEEAIAYGRRLAREEGILSGIST 270
Query: 233 GAVVKAYEKV--RP---EGTTVLIFPDDGFKY 259
GA + A KV RP + V+I P G +Y
Sbjct: 271 GAALAAAIKVAKRPANKDKLIVMIQPSFGERY 302
>gb|AAG01002.1|AF287914_1 (AF287914) O-acetylserine lyase [Selenomonas ruminantium]
Length = 310
Score = 101 bits (248), Expect = 1e-20
Identities = 78/273 (28%), Positives = 134/273 (48%), Gaps = 24/273 (8%)
Query: 5 KLEFFNPFSRSIKDRAVYNMLIKALRSGEIDGTNVLYEATSGNVGISIAALSAVFGLKFR 64
KLE+ NP + S+KDR M+ +A + G+I V+ E TSGN GI +A+ +A G K
Sbjct: 36 KLEYLNP-AGSVKDRIAKAMIEQAEKEGKITKDTVIIEPTSGNTGIGLASFAAARGYKAI 94
Query: 65 AYIPKPTPKTTELLIKVFGAEVVRTN-FDTIDKKFVEFVKLEARRDKALNLNQFENDANF 123
+P+ L+K +GA++V T+ + + +L A +QF N AN
Sbjct: 95 LTMPETMSVERRNLLKAYGAQIVLTDGAKGMKGAIAKAEELAKETPNAFIPSQFTNQANP 154
Query: 124 EAHYYGTARELEEQLRSIDKIPEIIIAGIGTSGHIAGISKYFKERYETKIIGVVPAKGET 183
H T E+ + K+ ++ IAG+GT G + G+ +Y K+ + + +V + E+
Sbjct: 155 AIHEATTGPEIWQDAEG--KV-DVFIAGVGTGGTLTGVGRYLKK--QNAAVHIVAVEPES 209
Query: 184 IPGIKRLETRPKWFFKVEV------------DEVVEVTAREAFEGILKVARSDGLLIGMS 231
P + + P + DEV+ ++ +AF+ + A S+G+L+G+S
Sbjct: 210 SPVLSQGTAGPHKIQGIGAGFVPETLDTKVYDEVLPISNEDAFKYGRQFAHSEGVLVGIS 269
Query: 232 SGAVVKAYEKV--RPE---GTTVLIFPDDGFKY 259
+GA + A ++ RPE V + PD G +Y
Sbjct: 270 AGAALAAAVQLAKRPEFAGKNIVALLPDTGDRY 302
>pir||T23591 cysteine synthase (EC 4.2.99.8) K10H10.2 [similarity] -
Caenorhabditis elegans >gi|3878538|emb|CAB05778.1|
(Z83236) contains similarity to Pfam domain: PF00291
(Pyridoxal-phosphate dependent enzyme), Score=428.1,
E-value=2.6e-125, N=1~cDNA EST yk115e1.5 comes from this
gene; cDNA EST yk115e1.3 comes from this gene~cDNA EST
yk156a12.3 comes from this gene; c>
Length = 337
Score = 100 bits (247), Expect = 2e-20
Identities = 87/264 (32%), Positives = 131/264 (48%), Gaps = 24/264 (9%)
Query: 5 KLEFFNPFSRSIKDRAVYNMLIKALRSGEID-GTNVLYEATSGNVGISIAALSAVFGLKF 63
K+E+ NP + S+KDR +NM+ A ++G I G VL E TSGN+GI++A + G K
Sbjct: 36 KVEYMNP-ACSVKDRIAFNMIDTAEKAGLITPGKTVLIEPTSGNMGIALAYCGKLRGYKV 94
Query: 64 RAYIPKPTPKTTELLIKVFGAEVVRTNFDTIDKKFVEFVKLEARRD---KALNLNQFEND 120
+P L+K +GAEV+ T+ T K V+ + E RD A LNQF N
Sbjct: 95 ILTMPASMSIERRCLLKAYGAEVILTDPATAVKGAVQ--RAEELRDVIPNAYILNQFGNP 152
Query: 121 ANFEAHYYGTARELEEQLRSIDKIPEIIIAGIGTSGHIAGISKYFKER-----------Y 169
AN EAHY T E+ Q + K+ +I+ G+G+ G G+ ++ KE+ +
Sbjct: 153 ANPEAHYKTTGPEIWRQTQG--KV-DIVCFGVGSGGTCTGVGRFLKEKNPSVQVFPVEPF 209
Query: 170 ETKIIGVVPAKGETIPGIKRLETRPKWFFKVEVDEVVEVTAREAFEGILKVARSDGLLIG 229
E+ +I +P I G+ P E + V + +A K+A + +L G
Sbjct: 210 ESSVINGLPHSPHKIQGM-GTGMIPDILDLTLFSEALRVHSDDAIAMAKKLADEESILGG 268
Query: 230 MSSGAVVKAYEKV--RPEGTTVLI 251
+SSGA V A ++ RPE LI
Sbjct: 269 ISSGANVCAAVQLAKRPENKGKLI 292
>sp|P11096|CYSK_ECOLI CYSTEINE SYNTHASE A (O-ACETYLSERINE SULFHYDRYLASE A)
(O-ACETYLSERINE (THIOL)-LYASE A) (CSASE A) (SULFATE
STARVATION-INDUCED PROTEIN 5) (SSI5)
>gi|7428372|pir||SYECAC cysteine synthase (EC 4.2.99.8)
A - Escherichia coli >gi|41201|emb|CAA31137.1| (X12615)
O-acetylserine sulfhydrylase (AA 1 - 323) [Escherichia
coli] >gi|1788754|gb|AAC75467.1| (AE000329) cysteine
synthase A, O-acetylserine sulfhydrolase A [Escherichia
coli K12]
Length = 323
Score = 100 bits (246), Expect = 2e-20
Identities = 85/281 (30%), Positives = 131/281 (46%), Gaps = 29/281 (10%)
Query: 4 AKLEFFNPFSRSIKDRAVYNMLIKALRSGEIDGTNVLYEATSGNVGISIAALSAVFGLKF 63
AK+E NP S S+K R NM+ A + G + L E TSGN GI++A ++A G K
Sbjct: 30 AKVESRNP-SFSVKCRIGANMIWDAEKRGVLKPGVELVEPTSGNTGIALAYVAAARGYKL 88
Query: 64 RAYIPKPTPKTTELLIKVFGAEVVRTNFDTIDKKFVEFVK--LEARRDKALNLNQFENDA 121
+P+ L+K GA +V T K ++ + + + +K L L QF N A
Sbjct: 89 TLTMPETMSIERRKLLKALGANLVLTEGAKGMKGAIQKAEEIVASNPEKYLLLQQFSNPA 148
Query: 122 NFEAHYYGTARELEEQLRSIDKIPEIIIAGIGTSGHIAGISKYFK-------------ER 168
N E H T E+ E D ++ IAG+GT G + G+S+Y K E
Sbjct: 149 NPEIHEKTTGPEIWE---DTDGQVDVFIAGVGTGGTLTGVSRYIKGTKGKTDLISVAVEP 205
Query: 169 YETKIIGVVPAKGETIPGIKRLETRPKWFFKVE-----VDEVVEVTAREAFEGILKVARS 223
++ +I A E PG +++ F VD+V+ +T EA ++
Sbjct: 206 TDSPVIAQALAGEEIKPGPHKIQGIGAGFIPANLDLKLVDKVIGITNEEAISTARRLMEE 265
Query: 224 DGLLIGMSSGAVVKAYEKVRPEGT-----TVLIFPDDGFKY 259
+G+L G+SSGA V A K++ + + V+I P G +Y
Sbjct: 266 EGILAGISSGAAVAAALKLQEDESFTNKNIVVILPSSGERY 306
>dbj|BAA16288.1| (D90871) CYSTEINE SYNTHASE A (EC 4.2.99.8) (O-ACETYLSERINE
SULFHYDRYLASE A) (O-ACETYLSERINE (THIOL)-LYASE A) (CSASE
A). [Escherichia coli]
Length = 322
Score = 100 bits (246), Expect = 2e-20
Identities = 85/281 (30%), Positives = 131/281 (46%), Gaps = 29/281 (10%)
Query: 4 AKLEFFNPFSRSIKDRAVYNMLIKALRSGEIDGTNVLYEATSGNVGISIAALSAVFGLKF 63
AK+E NP S S+K R NM+ A + G + L E TSGN GI++A ++A G K
Sbjct: 29 AKVESRNP-SFSVKCRIGANMIWDAEKRGVLKPGVELVEPTSGNTGIALAYVAAARGYKL 87
Query: 64 RAYIPKPTPKTTELLIKVFGAEVVRTNFDTIDKKFVEFVK--LEARRDKALNLNQFENDA 121
+P+ L+K GA +V T K ++ + + + +K L L QF N A
Sbjct: 88 TLTMPETMSIERRKLLKALGANLVLTEGAKGMKGAIQKAEEIVASNPEKYLLLQQFSNPA 147
Query: 122 NFEAHYYGTARELEEQLRSIDKIPEIIIAGIGTSGHIAGISKYFK-------------ER 168
N E H T E+ E D ++ IAG+GT G + G+S+Y K E
Sbjct: 148 NPEIHEKTTGPEIWE---DTDGQVDVFIAGVGTGGTLTGVSRYIKGTKGKTDLISVAVEP 204
Query: 169 YETKIIGVVPAKGETIPGIKRLETRPKWFFKVE-----VDEVVEVTAREAFEGILKVARS 223
++ +I A E PG +++ F VD+V+ +T EA ++
Sbjct: 205 TDSPVIAQALAGEEIKPGPHKIQGIGAGFIPANLDLKLVDKVIGITNEEAISTARRLMEE 264
Query: 224 DGLLIGMSSGAVVKAYEKVRPEGT-----TVLIFPDDGFKY 259
+G+L G+SSGA V A K++ + + V+I P G +Y
Sbjct: 265 EGILAGISSGAAVAAALKLQEDESFTNKNIVVILPSSGERY 305
>pir||S74512 cystathionine beta-synthase (EC 4.2.1.22) cysM [similarity] -
Synechocystis sp. (strain PCC 6803)
>gi|1651736|dbj|BAA16664.1| (D90899) cysteine synthase
[Synechocystis sp.]
Length = 325
Score = 99.1 bits (243), Expect = 5e-20
Identities = 84/279 (30%), Positives = 126/279 (45%), Gaps = 29/279 (10%)
Query: 5 KLEFFNPFSRSIKDRAVYNMLIKALRSGEIDGTNVLYEATSGNVGISIAALSAVFGLKFR 64
K EF NP S+KDRA ++ A + G++ + E T+GN GI +A + G K
Sbjct: 33 KAEFMNP-GGSVKDRAALGIIETAEKEGKLKPGGTVVEGTAGNTGIGLAHICNAKGYKCL 91
Query: 65 AYIPKPTPKTTELLIKVFGAEVVRTNFDTIDKKFVEFVKLEAR----RDKALNLNQFEND 120
IP + L++ GAE VRT + +VKL R D A+ NQF+N
Sbjct: 92 IVIPDTQSQEKIDLLRTLGAE-VRTVPAVPYRDPNNYVKLSGRIAAELDNAIWANQFDNL 150
Query: 121 ANFEAHYYGTARELEEQLRSIDKIPEIIIAGIGTSGHIAGISKYFKERYETKIIGVVPAK 180
AN +AHY+ T E+ +Q D + +A GT G AG++ Y KE+ E V
Sbjct: 151 ANRDAHYHTTGPEIWQQ---TDGKVDAWVAATGTGGTYAGVALYLKEQSEAVQCVVADPM 207
Query: 181 GETIPG-IKRLETRPKW---------------FFKVEVDEVVEVTAREAFEGILKVARSD 224
G + IK E P V +D+ V++ EA + ++ R D
Sbjct: 208 GSGLYSFIKTGEINPSGNSITEGIGNSRITANMENVPIDDAVQIDDPEALRVVYQLLRRD 267
Query: 225 GLL----IGMSSGAVVKAYEKVRPEGTTVLIFPDDGFKY 259
GL +G++ GA + +K+ P T V + D G +Y
Sbjct: 268 GLFMGGSVGINVGAAYQLAKKLGPGHTIVTVLCDGGARY 306
>pir||T36133 cysteine synthase (EC 4.2.99.8) SCE19A.10c [similarity] -
Streptomyces coelicolor >gi|5531359|emb|CAB50991.1|
(AL096852) putative cysteine synthase [Streptomyces
coelicolor A3(2)]
Length = 316
Score = 98.7 bits (242), Expect = 7e-20
Identities = 75/268 (27%), Positives = 129/268 (47%), Gaps = 16/268 (5%)
Query: 3 FAKLEFFNPFSRSIKDRAVYNMLIKALRSGEIDGTNVLYEATSGNVGISIAALSAVFGLK 62
+AKLE NP + SIKDR +M+ +A + G + + E TSGN GIS+A + + G +
Sbjct: 30 WAKLEDRNP-TGSIKDRPALHMIEQAEKDGRLTQGCTILEPTSGNTGISLAMAARLKGYR 88
Query: 63 FRAYIPKPTPKTTELLIKVFGAEVVRTNFDTIDKKFVEFVK-LEARRDKALNLNQFENDA 121
+P+ T + L+ ++GAE++ + V K L A + L Q+ N
Sbjct: 89 IVCVMPENTSQERRDLLTMWGAEIISSPAAGGSNTAVRVAKELSAEHPDWVMLYQYGNPD 148
Query: 122 NFEAHYYGTARELEEQLRSIDKIPEIIIAGIGTSGHIAGISKYFKE-RYETKIIGVVPAK 180
N AHY GT E+ L S+ +AG+GT+G + G+ +Y +E + + KI+ P
Sbjct: 149 NAGAHYAGTGPEILADLPSVTH----FVAGLGTTGTLMGVGRYLREHKPDVKIVAAEPRY 204
Query: 181 GETIPGIKRLETR--PKWFFKVEVDEVVEVTAREAFEGILKVARSDGLLIGMSSGA---- 234
+ + G++ L+ P+ + + V + +A ++ + +G+ G+S+GA
Sbjct: 205 DDLVYGLRNLDEGFVPELYDASVLTTRFSVGSADAVTRTRELLQQEGIFAGVSTGAALHA 264
Query: 235 ---VVKAYEKVRPEGTTVLIFPDDGFKY 259
V K K V + D G+KY
Sbjct: 265 AIGVGKKAVKAGESADIVFVVADGGWKY 292
>pir||T47233 cysteine synthase (EC 4.2.99.8) cysK - Lactococcus lactis subsp.
cremoris >gi|6513596|gb|AAF14694.1|AF131880_2 (AF131880)
O-acetylserine sulfhydrylase CysK [Lactococcus lactis
subsp. cremoris]
Length = 317
Score = 98.7 bits (242), Expect = 7e-20
Identities = 74/242 (30%), Positives = 114/242 (46%), Gaps = 13/242 (5%)
Query: 3 FAKLEFFNPFSRSIKDRAVYNMLIKALRSGEIDGTNVLYEATSGNVGISIAALSAVFGLK 62
+ KLE+FNP S+KDR M+ +A G + + E TSGN GI +A A G
Sbjct: 31 YLKLEYFNP-GGSVKDRIALQMIRQAEADGRLKKGGTIVEPTSGNTGIGLAMAGAALGYN 89
Query: 63 FRAYIPKPTPKTTELLIKVFGAEVVRTNFDTIDKKFVEFVKLEARRDKALNLNQFENDAN 122
+P K LI+ +GAE++ T K ++ + + QFEN AN
Sbjct: 90 VVIIMPDSYSKERRQLIQAYGAELILTPAADGIKAAIDLGQKLVEENGWFMPMQFENPAN 149
Query: 123 FEAHYYGTARELEEQLRSIDKIPEIIIAGIGTSGHIAGISKYFK-ERYETKIIGVVPAKG 181
+AH T E+ E + + +A GT G I+G+S Y K + + K V PA+
Sbjct: 150 LKAHELTTGPEIIEAFG--ENGLDAFVACAGTGGTISGVSHYLKSQNSKIKTFVVEPAES 207
Query: 182 ETIPGIK----RLETRPKWFFKVEV-----DEVVEVTAREAFEGILKVARSDGLLIGMSS 232
+ G + R++ F + D V+ VT+ EA E K+ +++G L+G+SS
Sbjct: 208 PILTGGESGPHRIQGIGIPFMSPNLDTEAYDRVINVTSDEALETARKIGKNEGFLVGISS 267
Query: 233 GA 234
GA
Sbjct: 268 GA 269
>gb|AAB52276.1| (U97004) contains similarity to Pfam domain PF00291
(S_T_dehydratase), Score=281.7, E-value=2.9e-81, N=1
[Caenorhabditis elegans]
Length = 337
Score = 98.3 bits (241), Expect = 9e-20
Identities = 91/302 (30%), Positives = 146/302 (48%), Gaps = 31/302 (10%)
Query: 5 KLEFFNPFSRSIKDRAVYNMLIKALRSGEI-DGTNVLYEATSGNVGISIAALSAVFGLKF 63
K+E+ NP S S+KDR +M+ +A ++G I G VL E TSGN+GI++A + + G K
Sbjct: 36 KVEYLNP-SCSVKDRIAKSMVDEAEKAGTIVPGKTVLVEGTSGNLGIALAHIGKIRGYKV 94
Query: 64 RAYIPKPTPKTTELLIKVFGAEVVRTNFDTIDKKFVEFVKLEARRDKALN---LNQFEND 120
+P +++ +GAEV+ + D + K+E DK N L+QF N
Sbjct: 95 ILVMPATMSVERRAMLRAYGAEVILS--DPAEGHPGVIKKVEMLVDKLPNAHCLDQFSNP 152
Query: 121 ANFEAHYYGTARELEEQLRSIDKIPEIIIAGIGTSGHIAGISKYFKER-----------Y 169
AN AHY T E+ Q K+ +I+ G+G+SG + G+ +Y +E+ Y
Sbjct: 153 ANPAAHYRTTGPEIWRQTEG--KV-DIVCFGVGSSGTVTGVGRYLREQNPNIEIYPVEPY 209
Query: 170 ETKIIGVVPAKGETIPGIKRLETRPKWFFKVEVDEVVEVTAREAFEGILKVARSDGLLIG 229
E+ ++ +P I GI P + E++ + + +A + ++A + +L G
Sbjct: 210 ESSVLSGLPRGPHKIQGI-GAGIVPGNVDRSLFTEILRIKSDDAMQMARRLADEEAILGG 268
Query: 230 MSSGA-VVKAYEKV-RPEG------TTVLIFPDDGFKYGEIFEMLLGEAQGKISSRTSQL 281
+SSGA VV A E RPE TTV F + F E++ +L E S +
Sbjct: 269 ISSGANVVAAVELASRPENKGKLIVTTVNSFAERYFT-TELYSDVLNEVSQLTFSSDDEA 327
Query: 282 QG 283
G
Sbjct: 328 MG 329
>gi|4557415 cystathionine-beta-synthase; human cystathionine-beta-synthase
[Homo sapiens] >gi|11423579|ref|XP_009786.1|
cystathionine-beta-synthase [Homo sapiens]
>gi|543959|sp|P35520|CBS_HUMAN CYSTATHIONINE
BETA-SYNTHASE (SERINE SULFHYDRASE) (BETA-THIONASE)
>gi|11379859|pir||A55760 cystathionine beta-synthase (EC
4.2.1.22) - human >gi|388716|gb|AAA19874.1| (L19501)
cystathionine beta-synthase [Homo sapiens]
>gi|558582|emb|CAA57656.1| (X82166) cystathionine
beta-synthase [Homo sapiens] >gi|1289362|gb|AAA98524.1|
(L14577) cystathionine beta-synthase [Homo sapiens]
>gi|3776242|gb|AAC64683.1| (AF042836) cystathionine
beta-synthase major isoform [Homo sapiens]
Length = 551
Score = 97.9 bits (240), Expect = 1e-19
Identities = 84/280 (30%), Positives = 134/280 (47%), Gaps = 29/280 (10%)
Query: 4 AKLEFFNPFSRSIKDRAVYNMLIKALRSGEIDGTNVLYEATSGNVGISIAALSAVFGLKF 63
AK EFFN S+KDR M+ A R G + + + E TSGN GI +A +AV G +
Sbjct: 107 AKCEFFNA-GGSVKDRISLRMIEDAERDGTLKPGDTIIEPTSGNTGIGLALAAAVRGYRC 165
Query: 64 RAYIPKPTPKTTELLIKVFGAEVVRT----NFDTIDKKFVEFVKLEARRDKALNLNQFEN 119
+P+ +++ GAE+VRT FD+ + +L+ + L+Q+ N
Sbjct: 166 IIVMPEKMSSEKVDVLRALGAEIVRTPTNARFDSPESHVGVAWRLKNEIPNSHILDQYRN 225
Query: 120 DANFEAHYYGTARELEEQLRSIDKIPEIIIAGIGTSGHIAGISKYFKERYE-TKIIGVVP 178
+N AHY TA E+ L+ D ++++A +GT G I GI++ KE+ +IIGV P
Sbjct: 226 ASNPLAHYDTTADEI---LQQCDGKLDMLVASVGTGGTITGIARKLKEKCPGCRIIGVDP 282
Query: 179 AKGETIPGIKRLETRPKWFFKVE---------------VDEVVEVTAREAFEGILKVARS 223
+G + + L + ++VE VD+ + EAF +
Sbjct: 283 -EGSILAEPEELNQTEQTTYEVEGIGYDFIPTVLDRTVVDKWFKSNDEEAFTFARMLIAQ 341
Query: 224 DGLLIGMSSGA----VVKAYEKVRPEGTTVLIFPDDGFKY 259
+GLL G S+G+ VKA ++++ V+I PD Y
Sbjct: 342 EGLLCGGSAGSTVAVAVKAAQELQEGQRCVVILPDSVRNY 381
>gb|AAC64684.1| (AF042836) cystathionine beta-synthase minor isoform [Homo sapiens]
Length = 565
Score = 97.9 bits (240), Expect = 1e-19
Identities = 84/280 (30%), Positives = 134/280 (47%), Gaps = 29/280 (10%)
Query: 4 AKLEFFNPFSRSIKDRAVYNMLIKALRSGEIDGTNVLYEATSGNVGISIAALSAVFGLKF 63
AK EFFN S+KDR M+ A R G + + + E TSGN GI +A +AV G +
Sbjct: 107 AKCEFFNA-GGSVKDRISLRMIEDAERDGTLKPGDTIIEPTSGNTGIGLALAAAVRGYRC 165
Query: 64 RAYIPKPTPKTTELLIKVFGAEVVRT----NFDTIDKKFVEFVKLEARRDKALNLNQFEN 119
+P+ +++ GAE+VRT FD+ + +L+ + L+Q+ N
Sbjct: 166 IIVMPEKMSSEKVDVLRALGAEIVRTPTNARFDSPESHVGVAWRLKNEIPNSHILDQYRN 225
Query: 120 DANFEAHYYGTARELEEQLRSIDKIPEIIIAGIGTSGHIAGISKYFKERYE-TKIIGVVP 178
+N AHY TA E+ L+ D ++++A +GT G I GI++ KE+ +IIGV P
Sbjct: 226 ASNPLAHYDTTADEI---LQQCDGKLDMLVASVGTGGTITGIARKLKEKCPGCRIIGVDP 282
Query: 179 AKGETIPGIKRLETRPKWFFKVE---------------VDEVVEVTAREAFEGILKVARS 223
+G + + L + ++VE VD+ + EAF +
Sbjct: 283 -EGSILAEPEELNQTEQTTYEVEGIGYDFIPTVLDRTVVDKWFKSNDEEAFTFARMLIAQ 341
Query: 224 DGLLIGMSSGA----VVKAYEKVRPEGTTVLIFPDDGFKY 259
+GLL G S+G+ VKA ++++ V+I PD Y
Sbjct: 342 EGLLCGGSAGSTVAVAVKAAQELQEGQRCVVILPDSVRNY 381
>emb|CAA61252.1| (X88562) cystathionine beta-synthase [Homo sapiens]
Length = 551
Score = 97.9 bits (240), Expect = 1e-19
Identities = 84/280 (30%), Positives = 134/280 (47%), Gaps = 29/280 (10%)
Query: 4 AKLEFFNPFSRSIKDRAVYNMLIKALRSGEIDGTNVLYEATSGNVGISIAALSAVFGLKF 63
AK EFFN S+KDR M+ A R G + + + E TSGN GI +A +AV G +
Sbjct: 107 AKCEFFNA-GGSVKDRISLRMIEDAERDGTLKPGDTIIEPTSGNTGIGLALAAAVRGYRC 165
Query: 64 RAYIPKPTPKTTELLIKVFGAEVVRT----NFDTIDKKFVEFVKLEARRDKALNLNQFEN 119
+P+ +++ GAE+VRT FD+ + +L+ + L+Q+ N
Sbjct: 166 IIVMPEKMSSEKVDVLRALGAEIVRTPTNARFDSPESHVGVAWRLKNEIPNSHILDQYRN 225
Query: 120 DANFEAHYYGTARELEEQLRSIDKIPEIIIAGIGTSGHIAGISKYFKERYE-TKIIGVVP 178
+N AHY TA E+ L+ D ++++A +GT G I GI++ KE+ +IIGV P
Sbjct: 226 ASNPLAHYDTTADEI---LQQCDGKLDMLVASVGTGGTITGIARKLKEKCPGCRIIGVDP 282
Query: 179 AKGETIPGIKRLETRPKWFFKVE---------------VDEVVEVTAREAFEGILKVARS 223
+G + + L + ++VE VD+ + EAF +
Sbjct: 283 -EGSILAEPEELNQTEQTTYEVEGIGYDFIPTVLDRTVVDKWFKSNDEEAFTFARMLIAQ 341
Query: 224 DGLLIGMSSGA----VVKAYEKVRPEGTTVLIFPDDGFKY 259
+GLL G S+G+ VKA ++++ V+I PD Y
Sbjct: 342 EGLLCGGSAGSTVAVAVKAAQELQEGQRCVVILPDSVRNY 381
>pir||T47936 cysteine synthase (EC 4.2.99.8) cysC1 [similarity] - Arabidopsis
thaliana >gi|4996616|dbj|BAA78560.1| (AB024282) cysteine
synthase [Arabidopsis thaliana]
>gi|5824334|emb|CAB54830.1| (AJ010505) cysteine synthase
[Arabidopsis thaliana] >gi|6850835|emb|CAB71074.1|
(AL132962) cysteine synthase AtcysC1 [Arabidopsis
thaliana]
Length = 368
Score = 97.5 bits (239), Expect = 2e-19
Identities = 81/248 (32%), Positives = 126/248 (50%), Gaps = 26/248 (10%)
Query: 4 AKLEFFNPFSRSIKDRAVYNMLIKALRSGEI-DGTNVLYEATSGNVGISIAALSAVFGLK 62
AK E F P + SIKDR M+ A + I G L E TSGN+GIS+A ++A+ G +
Sbjct: 78 AKQEHFQP-TCSIKDRPAIAMIADAEKKKLIIPGKTTLIEPTSGNMGISLAFMAAMKGYR 136
Query: 63 FRAYIPKPTPKTTELLIKVFGAEVVRTN-----FDTIDKKFVEFVKLEARRDKALNLNQF 117
+P T + ++ FGAE+V T+ T+ K + L A QF
Sbjct: 137 IIMTMPSYTSLERRVTMRSFGAELVLTDPAKGMGGTVKKAY----DLLDSTPDAFMCQQF 192
Query: 118 ENDANFEAHYYGTAREL-EEQLRSIDKIPEIIIAGIGTSGHIAGISKYFKERY-ETKIIG 175
N AN + H+ T E+ E+ L ++D I + GIG+ G ++G+ +Y K + KI G
Sbjct: 193 ANPANTQIHFDTTGPEIWEDTLGNVD----IFVMGIGSGGTVSGVGRYLKSKNPNVKIYG 248
Query: 176 VVPAKGETIPGIK---RLETRPKWFFKVEV------DEVVEVTAREAFEGILKVARSDGL 226
V PA+ + G K T FK E+ + V+EV++ +A + ++A +GL
Sbjct: 249 VEPAESNILNGGKPGPHAITGNGVGFKPEILDMDVMESVLEVSSEDAIKMARELALKEGL 308
Query: 227 LIGMSSGA 234
++G+SSGA
Sbjct: 309 MVGISSGA 316
>gb|AAF64226.1|AF248039_1 (AF248039) cystathionine beta-synthase [Oryctolagus cuniculus]
Length = 551
Score = 97.5 bits (239), Expect = 2e-19
Identities = 86/280 (30%), Positives = 134/280 (47%), Gaps = 29/280 (10%)
Query: 4 AKLEFFNPFSRSIKDRAVYNMLIKALRSGEIDGTNVLYEATSGNVGISIAALSAVFGLKF 63
AK EFFN S+KDR M+ A R+G + + + E TSGN GI +A +AV G +
Sbjct: 107 AKCEFFNA-GGSVKDRISLRMIEDAERAGTLRPGDTIIEPTSGNTGIGLALAAAVKGYRC 165
Query: 64 RAYIPKPTPKTTELLIKVFGAEVVRT----NFDTIDKKFVEFVKLEARRDKALNLNQFEN 119
+P+ +++ GAE+VRT FD+ + +L+ + L+Q+ N
Sbjct: 166 IIVMPEKMSLEKVDVLRALGAEIVRTPTNARFDSPESHVGVAWRLKQEIPNSHILDQYRN 225
Query: 120 DANFEAHYYGTARELEEQLRSIDKIPEIIIAGIGTSGHIAGISKYFKERYE-TKIIGVVP 178
+N AHY TA EE L+ D ++++A GT G I GI++ KE+ +IIGV P
Sbjct: 226 ASNPLAHYDTTA---EEILQQCDGKLDMLVASAGTGGTITGIARKLKEKCPGCQIIGVDP 282
Query: 179 AKGETIPGIKRLETRPKWFFKVE---------------VDEVVEVTAREAFEGILKVARS 223
+G + + L ++VE VD + T +EAF +
Sbjct: 283 -EGSILAEPEELNQTEVTAYEVEGIGYDFIPTVLDRTVVDRWFKSTDKEAFAFARMLIAQ 341
Query: 224 DGLLIGMSSGA----VVKAYEKVRPEGTTVLIFPDDGFKY 259
+GLL G S+G+ VKA ++++ V+I PD Y
Sbjct: 342 EGLLCGGSAGSAVAVAVKAAQELQEGQRCVVILPDSVRNY 381
>gi|6978611 cystathionine beta synthase [Rattus norvegicus]
>gi|111762|pir||JX0145 hemoprotein H-450 precursor - rat
>gi|220759|dbj|BAA00883.1| (D01098) hemoprotein H-450
[Rattus norvegicus]
Length = 547
Score = 97.1 bits (238), Expect = 2e-19
Identities = 85/280 (30%), Positives = 133/280 (47%), Gaps = 29/280 (10%)
Query: 4 AKLEFFNPFSRSIKDRAVYNMLIKALRSGEIDGTNVLYEATSGNVGISIAALSAVFGLKF 63
AK EFFN S+KDR M+ A R+G + + + E TSGN GI +A +AV G +
Sbjct: 104 AKCEFFNA-GGSVKDRISLRMIEDAERAGTLKPGDTIIEPTSGNTGIGLALAAAVKGYRC 162
Query: 64 RAYIPKPTPKTTELLIKVFGAEVVRT----NFDTIDKKFVEFVKLEARRDKALNLNQFEN 119
+P+ +++ GAE+VRT FD+ + +L+ + L+Q+ N
Sbjct: 163 IIVMPEKMSMEKVDVLRALGAEIVRTPTNARFDSPESHVGVAWRLKNEIPNSHILDQYRN 222
Query: 120 DANFEAHYYGTARELEEQLRSIDKIPEIIIAGIGTSGHIAGISKYFKERYE-TKIIGVVP 178
+N AHY TA EE L+ D ++++A GT G I GI++ KE+ KIIGV P
Sbjct: 223 ASNPLAHYDDTA---EEILQQCDGKVDMLVASAGTGGTITGIARKLKEKCPGCKIIGVDP 279
Query: 179 AKGETIPGIKRLETRPKWFFKVE---------------VDEVVEVTAREAFEGILKVARS 223
+G + + L + ++VE VD + ++F +
Sbjct: 280 -EGSILAEPEELNQTEQTAYEVEGIGYDFIPTVLDRAVVDRWFKSNDDDSFAFARMLISQ 338
Query: 224 DGLLIGMSSGA----VVKAYEKVRPEGTTVLIFPDDGFKY 259
+GLL G SSG+ VKA ++++ V+I PD Y
Sbjct: 339 EGLLCGGSSGSAMAVAVKAAQELKEGQRCVVILPDSVRNY 378
>sp|P32232|CBS_RAT CYSTATHIONINE BETA-SYNTHASE (SERINE SULFHYDRASE) (BETA-THIONASE)
(HEMOPROTEIN H-450) >gi|285250|pir||A42790 cystathionine
beta-synthase (EC 4.2.1.22), splice form I [validated] -
rat >gi|206597|gb|AAB02042.1| (M88344) cystathionine
beta-synthase [Rattus norvegicus]
Length = 561
Score = 97.1 bits (238), Expect = 2e-19
Identities = 85/280 (30%), Positives = 133/280 (47%), Gaps = 29/280 (10%)
Query: 4 AKLEFFNPFSRSIKDRAVYNMLIKALRSGEIDGTNVLYEATSGNVGISIAALSAVFGLKF 63
AK EFFN S+KDR M+ A R+G + + + E TSGN GI +A +AV G +
Sbjct: 104 AKCEFFNA-GGSVKDRISLRMIEDAERAGTLKPGDTIIEPTSGNTGIGLALAAAVKGYRC 162
Query: 64 RAYIPKPTPKTTELLIKVFGAEVVRT----NFDTIDKKFVEFVKLEARRDKALNLNQFEN 119
+P+ +++ GAE+VRT FD+ + +L+ + L+Q+ N
Sbjct: 163 IIVMPEKMSMEKVDVLRALGAEIVRTPTNARFDSPESHVGVAWRLKNEIPNSHILDQYRN 222
Query: 120 DANFEAHYYGTARELEEQLRSIDKIPEIIIAGIGTSGHIAGISKYFKERYE-TKIIGVVP 178
+N AHY TA EE L+ D ++++A GT G I GI++ KE+ KIIGV P
Sbjct: 223 ASNPLAHYDDTA---EEILQQCDGKVDMLVASAGTGGTITGIARKLKEKCPGCKIIGVDP 279
Query: 179 AKGETIPGIKRLETRPKWFFKVE---------------VDEVVEVTAREAFEGILKVARS 223
+G + + L + ++VE VD + ++F +
Sbjct: 280 -EGSILAEPEELNQTEQTAYEVEGIGYDFIPTVLDRAVVDRWFKSNDDDSFAFARMLISQ 338
Query: 224 DGLLIGMSSGA----VVKAYEKVRPEGTTVLIFPDDGFKY 259
+GLL G SSG+ VKA ++++ V+I PD Y
Sbjct: 339 EGLLCGGSSGSAMAVAVKAAQELKEGQRCVVILPDSVRNY 378
>gb|AAA42024.1| (M88346) cystathionine beta-synthase [Rattus norvegicus]
Length = 547
Score = 97.1 bits (238), Expect = 2e-19
Identities = 85/280 (30%), Positives = 133/280 (47%), Gaps = 29/280 (10%)
Query: 4 AKLEFFNPFSRSIKDRAVYNMLIKALRSGEIDGTNVLYEATSGNVGISIAALSAVFGLKF 63
AK EFFN S+KDR M+ A R+G + + + E TSGN GI +A +AV G +
Sbjct: 104 AKCEFFNA-GGSVKDRISLRMIEDAERAGTLKPGDTIIEPTSGNTGIGLALAAAVKGYRC 162
Query: 64 RAYIPKPTPKTTELLIKVFGAEVVRT----NFDTIDKKFVEFVKLEARRDKALNLNQFEN 119
+P+ +++ GAE+VRT FD+ + +L+ + L+Q+ N
Sbjct: 163 IIVMPEKMSMEKVDVLRALGAEIVRTPTNARFDSPESHVGVAWRLKNEIPNSHILDQYRN 222
Query: 120 DANFEAHYYGTARELEEQLRSIDKIPEIIIAGIGTSGHIAGISKYFKERYE-TKIIGVVP 178
+N AHY TA EE L+ D ++++A GT G I GI++ KE+ KIIGV P
Sbjct: 223 ASNPLAHYDDTA---EEILQQCDGKVDMLVASAGTGGTITGIARKLKEKCPGCKIIGVDP 279
Query: 179 AKGETIPGIKRLETRPKWFFKVE---------------VDEVVEVTAREAFEGILKVARS 223
+G + + L + ++VE VD + ++F +
Sbjct: 280 -EGSILAEPEELNQTEQTAYEVEGIGYDFIPTVLDRAVVDRWFKSNDDDSFAFARMLISQ 338
Query: 224 DGLLIGMSSGA----VVKAYEKVRPEGTTVLIFPDDGFKY 259
+GLL G SSG+ VKA ++++ V+I PD Y
Sbjct: 339 EGLLCGGSSGSAMAVAVKAAQELKEGQRCVVILPDSVRNY 378
>pir||B42790 cystathionine beta-synthase (EC 4.2.1.22), splice form III - rat
Length = 546
Score = 97.1 bits (238), Expect = 2e-19
Identities = 85/280 (30%), Positives = 133/280 (47%), Gaps = 29/280 (10%)
Query: 4 AKLEFFNPFSRSIKDRAVYNMLIKALRSGEIDGTNVLYEATSGNVGISIAALSAVFGLKF 63
AK EFFN S+KDR M+ A R+G + + + E TSGN GI +A +AV G +
Sbjct: 104 AKCEFFNA-GGSVKDRISLRMIEDAERAGTLKPGDTIIEPTSGNTGIGLALAAAVKGYRC 162
Query: 64 RAYIPKPTPKTTELLIKVFGAEVVRT----NFDTIDKKFVEFVKLEARRDKALNLNQFEN 119
+P+ +++ GAE+VRT FD+ + +L+ + L+Q+ N
Sbjct: 163 IIVMPEKMSMEKVDVLRALGAEIVRTPTNARFDSPESHVGVAWRLKNEIPNSHILDQYRN 222
Query: 120 DANFEAHYYGTARELEEQLRSIDKIPEIIIAGIGTSGHIAGISKYFKERYE-TKIIGVVP 178
+N AHY TA EE L+ D ++++A GT G I GI++ KE+ KIIGV P
Sbjct: 223 ASNPLAHYDDTA---EEILQQCDGKVDMLVASAGTGGTITGIARKLKEKCPGCKIIGVDP 279
Query: 179 AKGETIPGIKRLETRPKWFFKVE---------------VDEVVEVTAREAFEGILKVARS 223
+G + + L + ++VE VD + ++F +
Sbjct: 280 -EGSILAEPEELNQTEQTAYEVEGIGYDFIPTVLDRAVVDRWFKSNDDDSFAFARMLISQ 338
Query: 224 DGLLIGMSSGA----VVKAYEKVRPEGTTVLIFPDDGFKY 259
+GLL G SSG+ VKA ++++ V+I PD Y
Sbjct: 339 EGLLCGGSSGSAMAVAVKAAQELKEGQRCVVILPDSVRNY 378
>pir||C42790 cystathionine beta-synthase (EC 4.2.1.22), splice form IV - rat
Length = 478
Score = 97.1 bits (238), Expect = 2e-19
Identities = 85/280 (30%), Positives = 133/280 (47%), Gaps = 29/280 (10%)
Query: 4 AKLEFFNPFSRSIKDRAVYNMLIKALRSGEIDGTNVLYEATSGNVGISIAALSAVFGLKF 63
AK EFFN S+KDR M+ A R+G + + + E TSGN GI +A +AV G +
Sbjct: 104 AKCEFFNA-GGSVKDRISLRMIEDAERAGTLKPGDTIIEPTSGNTGIGLALAAAVKGYRC 162
Query: 64 RAYIPKPTPKTTELLIKVFGAEVVRT----NFDTIDKKFVEFVKLEARRDKALNLNQFEN 119
+P+ +++ GAE+VRT FD+ + +L+ + L+Q+ N
Sbjct: 163 IIVMPEKMSMEKVDVLRALGAEIVRTPTNARFDSPESHVGVAWRLKNEIPNSHILDQYRN 222
Query: 120 DANFEAHYYGTARELEEQLRSIDKIPEIIIAGIGTSGHIAGISKYFKERYE-TKIIGVVP 178
+N AHY TA EE L+ D ++++A GT G I GI++ KE+ KIIGV P
Sbjct: 223 ASNPLAHYDDTA---EEILQQCDGKVDMLVASAGTGGTITGIARKLKEKCPGCKIIGVDP 279
Query: 179 AKGETIPGIKRLETRPKWFFKVE---------------VDEVVEVTAREAFEGILKVARS 223
+G + + L + ++VE VD + ++F +
Sbjct: 280 -EGSILAEPEELNQTEQTAYEVEGIGYDFIPTVLDRAVVDRWFKSNDDDSFAFARMLISQ 338
Query: 224 DGLLIGMSSGA----VVKAYEKVRPEGTTVLIFPDDGFKY 259
+GLL G SSG+ VKA ++++ V+I PD Y
Sbjct: 339 EGLLCGGSSGSAMAVAVKAAQELKEGQRCVVILPDSVRNY 378
>sp|Q10624|CYSM_MYCTU CYSTEINE SYNTHASE B (O-ACETYLSERINE SULFHYDRYLASE B)
(O-ACETYLSERINE (THIOL)-LYASE B) (CSASE B)
>gi|7436952|pir||D70771 cysteine synthase (EC 4.2.99.8)
cysM [similarity] - Mycobacterium tuberculosis (strain
H37RV) >gi|1340102|emb|CAA98100.1| (Z73902) cysM
[Mycobacterium tuberculosis]
Length = 323
Score = 96.3 bits (236), Expect = 3e-19
Identities = 80/294 (27%), Positives = 138/294 (46%), Gaps = 25/294 (8%)
Query: 3 FAKLEFFNPFSRSIKDRAVYNMLIKALRSGEIDGTNVLYEATSGNVGISIAALSAVFGLK 62
+AKLE NP + SIKDR M+ +A G + + E TSGN GIS+A + + G +
Sbjct: 38 WAKLEDRNP-TGSIKDRPAVRMIEQAEADGLLRPGATILEPTSGNTGISLAMAARLKGYR 96
Query: 63 FRAYIPKPTPKTTELLIKVFGAEVVRTNFDTIDKKFVEFVK-LEARRDKALNLNQFENDA 121
+P+ T L++++GA+++ + + V K L A + L Q+ N A
Sbjct: 97 LICVMPENTSVERRQLLELYGAQIIFSAAEGGSNTAVATAKELAATNPSWVMLYQYGNPA 156
Query: 122 NFEAHYYGTARELEEQLRSIDKIPEI--IIAGIGTSGHIAGISKYFKERY-ETKIIGVVP 178
N ++HY GT EL + +PEI +AG+GT+G + G ++ +E KI+ P
Sbjct: 157 NTDSHYCGTGPEL------LADLPEITHFVAGLGTTGTLMGTGRFLREHVANVKIVAAEP 210
Query: 179 AKGETIPGIKRLETR--PKWFFKVEVDEVVEVTAREAFEGILKVARSDGLLIGMSSGAVV 236
GE + ++ ++ P+ + + V A +A ++ ++G+ G+S+GAV+
Sbjct: 211 RYGEGVYALRNMDEGFVPELYDPEILTARYSVGAVDAVRRTRELVHTEGIFAGISTGAVL 270
Query: 237 KAYEKV-------RPEGTTVLIFPDDGFKYGEIFEMLLGEAQGKISSRTSQLQG 283
A V L+ D G+KY + G G + + L+G
Sbjct: 271 HAALGVGAGALAAGERADIALVVADAGWKY-----LSTGAYAGSLDDAETALEG 319
>gb|AAF50862.1| (AE003569) CG1753 gene product [alt 1] [Drosophila melanogaster]
>gi|7295551|gb|AAF50863.1| (AE003569) CG1753 gene
product [alt 2] [Drosophila melanogaster]
Length = 522
Score = 96.3 bits (236), Expect = 3e-19
Identities = 82/276 (29%), Positives = 130/276 (46%), Gaps = 29/276 (10%)
Query: 3 FAKLEFFNPFSRSIKDRAVYNMLIKALRSGEIDGTNVLYEATSGNVGISIAALSAVFGLK 62
+AK EF NP S+KDR Y M+ A G + + E TSGN GI +A AV G K
Sbjct: 75 YAKCEFLNP-GGSVKDRIGYRMVQDAEEQGLLKPGYTIIEPTSGNTGIGLAMACAVKGYK 133
Query: 63 FRAYIPKPTPKTTELLIKVFGAEVVRT----NFDTIDKKFVEFVKLEARRDKALNLNQFE 118
+P+ ++ GA+++RT +D+ + +L+ ++ L+Q+
Sbjct: 134 CIIVMPEKMSNEKVSALRTLGAKIIRTPTEAAYDSPEGLIYVAQQLQRETPNSIVLDQYR 193
Query: 119 NDANFEAHYYGTARELEEQLRSIDKIPEIIIAGIGTSGHIAGISKYFKERYET-KIIGVV 177
N N AHY GTA E+ L +D ++I+ GT+G I+GI + KE+ + +I+GV
Sbjct: 194 NAGNPLAHYDGTAAEI---LWQLDNKVDMIVVSAGTAGTISGIGRKIKEQVPSCQIVGVD 250
Query: 178 PAKGETIPGIKRLETRPKWFFKVE-----------VDEVVEVTAR----EAFEGILKVAR 222
P G + L F++VE D VV+V + + F ++
Sbjct: 251 P-YGSILARPAELNKTDVQFYEVEGIGYDFPPTVFDDTVVDVWTKIGDSDCFPMSRRLNA 309
Query: 223 SDGLLIGMSSG----AVVKAYEKVRPEGTTVLIFPD 254
+GLL G SSG A ++ K++ V+I PD
Sbjct: 310 EEGLLCGGSSGGAMHAALEHARKLKKGQRCVVILPD 345
>gb|AAA23654.1| (M21451) cysK protein [Escherichia coli]
Length = 323
Score = 96.0 bits (235), Expect = 5e-19
Identities = 84/281 (29%), Positives = 129/281 (45%), Gaps = 29/281 (10%)
Query: 4 AKLEFFNPFSRSIKDRAVYNMLIKALRSGEIDGTNVLYEATSGNVGISIAALSAVFGLKF 63
AK+E NP S S+K R NM+ A + G + L E TSGN GI++A ++A G K
Sbjct: 30 AKVESRNP-SFSVKCRIGANMIWDAEKRGVLKPGVELVEPTSGNTGIALAYVAAARGYKL 88
Query: 64 RAYIPKPTPKTTELLIKVFGAEVVRTNFDTIDKKFVEFVK--LEARRDKALNLNQFENDA 121
+P+ L+K GA +V T K ++ + + + +K L L QF N A
Sbjct: 89 TLTMPETMSIERRKLLKALGANLVLTEGAKGMKGAIQKAEEIVASNPEKYLLLQQFSNPA 148
Query: 122 NFEAHYYGTARELEEQLRSIDKIPEIIIAGIGTSGHIAGISKYFK-------------ER 168
N E H T E+ E D ++ IAG+GT G G++ Y K E
Sbjct: 149 NPEIHEKTTGPEIWE---DTDGQVDVFIAGVGTGGTWTGVTPYIKGTKGKTDLISVAVEP 205
Query: 169 YETKIIGVVPAKGETIPGIKRLETRPKWFFKVE-----VDEVVEVTAREAFEGILKVARS 223
++ +I A E PG +++ F VD+V+ +T EA ++
Sbjct: 206 TDSPVIAQALAGEEIKPGPHKIQGIGAGFIPANLDLKLVDKVIGITNEEAISTARRLMEE 265
Query: 224 DGLLIGMSSGAVVKAYEKVRPEGT-----TVLIFPDDGFKY 259
+G+L G+SSGA V A K++ + + V+I P G +Y
Sbjct: 266 EGILAGISSGAAVAAALKLQEDESFTNKNIVVILPSSGERY 306
>emb|CAB70691.1| (AL137314) hypothetical protein [Homo sapiens]
Length = 475
Score = 95.6 bits (234), Expect = 6e-19
Identities = 83/280 (29%), Positives = 133/280 (46%), Gaps = 29/280 (10%)
Query: 4 AKLEFFNPFSRSIKDRAVYNMLIKALRSGEIDGTNVLYEATSGNVGISIAALSAVFGLKF 63
AK EFFN S+KDR M+ A R G + + + E TSGN GI +A +AV G +
Sbjct: 31 AKCEFFNA-GGSVKDRISLRMIEDAERDGTLKPGDTIIEPTSGNTGIGLALAAAVRGYRC 89
Query: 64 RAYIPKPTPKTTELLIKVFGAEVVRT----NFDTIDKKFVEFVKLEARRDKALNLNQFEN 119
+P+ +++ GAE+VRT FD+ + +L+ + L+Q+ N
Sbjct: 90 IIVMPEKMSSEKVDVLRALGAEIVRTPTNARFDSPESHVGVAWRLKNEIPNSHILDQYRN 149
Query: 120 DANFEAHYYGTARELEEQLRSIDKIPEIIIAGIGTSGHIAGISKYFKERYE-TKIIGVVP 178
+N HY TA E+ L+ D ++++A +GT G I GI++ KE+ +IIGV P
Sbjct: 150 ASNPLPHYDTTADEI---LQQCDGKLDMLVASVGTGGTITGIARKLKEKCPGCRIIGVDP 206
Query: 179 AKGETIPGIKRLETRPKWFFKVE---------------VDEVVEVTAREAFEGILKVARS 223
+G + + L + ++VE VD+ + EAF +
Sbjct: 207 -EGSILAEPEELNQTEQTTYEVEGIGYDFIPTVLDRTVVDKWFKSNDEEAFTLARMLIAQ 265
Query: 224 DGLLIGMSSGA----VVKAYEKVRPEGTTVLIFPDDGFKY 259
+GLL G S+G+ VKA ++++ V+I PD Y
Sbjct: 266 EGLLCGGSAGSTVAVAVKAAQELQEGQRCVVILPDSVRNY 305
>gb|AAD13393.1| (AF090120) cystathionine beta-synthetase; CBS [Takifugu rubripes]
Length = 585
Score = 94.4 bits (231), Expect = 1e-18
Identities = 82/255 (32%), Positives = 125/255 (48%), Gaps = 24/255 (9%)
Query: 5 KLEFFNPFSRSIKDRAVYNMLIKALRSGEIDGTNVLYEATSGNVGISIAALSAVFGLKFR 64
K EFF+ SIKDR M+ A R+G + + + E TSGN GI +A +++V G +R
Sbjct: 112 KCEFFSA-GGSIKDRIALRMVEDAERAGLLKPGDTIIEPTSGNTGIGLALVASVKG--YR 168
Query: 65 AYIPKPTPKTTEL--LIKVFGAEVVRT----NFDTIDKKFVEFVKLEARRDKALNLNQFE 118
I P + E ++K GAEVV T FD+ + + L+ + + L+Q+
Sbjct: 169 CVITMPDRMSMEKVDVLKALGAEVVHTPSSAPFDSPESQVGMAWCLKNKIPNSHILDQYR 228
Query: 119 NDANFEAHYYGTARELEEQLRSIDKIPEIIIAGIGTSGHIAGISKYFKERYETKIIGVVP 178
N +N AHY TA E+ EQ D ++++AGIGT G + G+++ KE+ T I+ V P
Sbjct: 229 NASNPLAHYDATAEEILEQ---CDGKLDMLVAGIGTGGTLTGVARKLKEKCPT-IVAVDP 284
Query: 179 AKGETIPGIKRLETR-----------PKWFFKVEVDEVVEVTAREAFEGILKVARSDGLL 227
I ++ P K VD +V +E F ++ R +GLL
Sbjct: 285 EGSLLIHSDDHCKSSYEVEGIGYDFVPTVLDKSLVDYFYKVNDKETFNMSRRLIRDEGLL 344
Query: 228 IGMSSGAVVKAYEKV 242
G SSG+ + A KV
Sbjct: 345 CGGSSGSAMAAAVKV 359
>pdb|1FCJ|A Chain A, Crystal Structure Of Oass Complexed With Chloride And
Sulfate >gi|11514512|pdb|1FCJ|B Chain B, Crystal
Structure Of Oass Complexed With Chloride And Sulfate
>gi|11514513|pdb|1FCJ|C Chain C, Crystal Structure Of
Oass Complexed With Chloride And Sulfate
>gi|11514514|pdb|1FCJ|D Chain D, Crystal Structure Of
Oass Complexed With Chloride And Sulfate
>gi|6980381|pdb|1OAS|A Chain A, O-Acetylserine
Sulfhydrylase From Salmonella Typhimurium
>gi|6980382|pdb|1OAS|B Chain B, O-Acetylserine
Sulfhydrylase From Salmonella Typhimurium
Length = 322
Score = 94.4 bits (231), Expect = 1e-18
Identities = 83/281 (29%), Positives = 129/281 (45%), Gaps = 29/281 (10%)
Query: 4 AKLEFFNPFSRSIKDRAVYNMLIKALRSGEIDGTNVLYEATSGNVGISIAALSAVFGLKF 63
AK+E NP S S+K R NM+ A + G + L E T+GN GI++A ++A G K
Sbjct: 29 AKVESRNP-SFSVKCRIGANMIWDAEKRGVLKPGVELVEPTNGNTGIALAYVAAARGYKL 87
Query: 64 RAYIPKPTPKTTELLIKVFGAEVVRTNFDTIDKKFVEFVKLEARRD--KALNLNQFENDA 121
+P+ L+K GA +V T K ++ + D K L L QF N A
Sbjct: 88 TLTMPETMSIERRKLLKALGANLVLTEGAKGMKGAIQKAEEIVASDPQKYLLLQQFSNPA 147
Query: 122 NFEAHYYGTARELEEQLRSIDKIPEIIIAGIGTSGHIAGISKYFK-------------ER 168
N E H T E+ E D ++ I+G+GT G + G+++Y K E
Sbjct: 148 NPEIHEKTTGPEIWE---DTDGQVDVFISGVGTGGTLTGVTRYIKGTKGKTDLITVAVEP 204
Query: 169 YETKIIGVVPAKGETIPGIKRLETRPKWFFKVE-----VDEVVEVTAREAFEGILKVARS 223
++ +I A E PG +++ F +D+VV +T EA ++
Sbjct: 205 TDSPVIAQALAGEEIKPGPHKIQGIGAGFIPGNLDLKLIDKVVGITNEEAISTARRLMEE 264
Query: 224 DGLLIGMSSGAVVKAYEKVRPEGT-----TVLIFPDDGFKY 259
+G+L G+SSGA V A K++ + + V+I P G +Y
Sbjct: 265 EGILAGISSGAAVAAALKLQEDESFTNKNIVVILPSSGERY 305
>pir||C82258 cysteine synthase A VC0968 [imported] - Vibrio cholerae (group O1
strain N16961) >gi|9655428|gb|AAF94130.1| (AE004178)
cysteine synthase A [Vibrio cholerae]
Length = 322
Score = 93.6 bits (229), Expect = 2e-18
Identities = 81/280 (28%), Positives = 130/280 (45%), Gaps = 28/280 (10%)
Query: 4 AKLEFFNPFSRSIKDRAVYNMLIKALRSGEIDGTNVLYEATSGNVGISIAALSAVFGLKF 63
AK+E NP S S+K R NM+ +A + G++ L E TSGN G+++A ++A G K
Sbjct: 30 AKIEARNP-SFSVKCRIGANMIWEAEKQGKLKPGVELVEPTSGNTGVALAFVAAARGYKL 88
Query: 64 RAYIPKPTPKTTELLIKVFGAEVVRTNFDTIDKKFVEFVK--LEARRDKALNLNQFENDA 121
+P+ L+K GA + T K + + + + +K L L QF N A
Sbjct: 89 TLTMPESMSLERRKLLKALGANLELTEAAKGMKGAIAKAEEIVASNPEKYLLLQQFNNPA 148
Query: 122 NFEAHYYGTARELEEQLRSIDKIPEIIIAGIGTSGHIAGISKYFK------------ERY 169
N + H T E+ + + D ++ +AG+GT G + G S+Y K E
Sbjct: 149 NPQIHEKTTGPEIWD---ATDGQIDVFVAGVGTGGTLTGTSRYIKGTQGKAILSVAVEPA 205
Query: 170 ETKIIGVVPAKGETIPGIKRLETRPKWFFKVE-----VDEVVEVTAREAFEGILKVARSD 224
E+ +I A E P +++ F +D V VT+ EA E ++ +
Sbjct: 206 ESPVITQALAGEEIKPAPHKIQGIGAGFIPGNLDLSLIDRVERVTSDEAIEMARRLMEEE 265
Query: 225 GLLIGMSSGAVVKAYEKVRP----EGTTVL-IFPDDGFKY 259
G+L G+SSGA V A ++ EG T++ + P G +Y
Sbjct: 266 GILAGISSGAAVVAANRIAQLPEFEGKTIVTVLPSSGERY 305
>pdb|1D6S|A Chain A, Crystal Structure Of The K41a Mutant Of O-Acetylserine
Sulfhydrylase Complexed In External Aldimine Linkage
With Methionine >gi|7767091|pdb|1D6S|B Chain B, Crystal
Structure Of The K41a Mutant Of O-Acetylserine
Sulfhydrylase Complexed In External Aldimine Linkage
With Methionine
Length = 322
Score = 92.1 bits (225), Expect = 7e-18
Identities = 82/281 (29%), Positives = 128/281 (45%), Gaps = 29/281 (10%)
Query: 4 AKLEFFNPFSRSIKDRAVYNMLIKALRSGEIDGTNVLYEATSGNVGISIAALSAVFGLKF 63
AK+E NP S S+ R NM+ A + G + L E T+GN GI++A ++A G K
Sbjct: 29 AKVESRNP-SFSVACRIGANMIWDAEKRGVLKPGVELVEPTNGNTGIALAYVAAARGYKL 87
Query: 64 RAYIPKPTPKTTELLIKVFGAEVVRTNFDTIDKKFVEFVKLEARRD--KALNLNQFENDA 121
+P+ L+K GA +V T K ++ + D K L L QF N A
Sbjct: 88 TLTMPETMSIERRKLLKALGANLVLTEGAKGMKGAIQKAEEIVASDPQKYLLLQQFSNPA 147
Query: 122 NFEAHYYGTARELEEQLRSIDKIPEIIIAGIGTSGHIAGISKYFK-------------ER 168
N E H T E+ E D ++ I+G+GT G + G+++Y K E
Sbjct: 148 NPEIHEKTTGPEIWE---DTDGQVDVFISGVGTGGTLTGVTRYIKGTKGKTDLITVAVEP 204
Query: 169 YETKIIGVVPAKGETIPGIKRLETRPKWFFKVE-----VDEVVEVTAREAFEGILKVARS 223
++ +I A E PG +++ F +D+VV +T EA ++
Sbjct: 205 TDSPVIAQALAGEEIKPGPHKIQGIGAGFIPGNLDLKLIDKVVGITNEEAISTARRLMEE 264
Query: 224 DGLLIGMSSGAVVKAYEKVRPEGT-----TVLIFPDDGFKY 259
+G+L G+SSGA V A K++ + + V+I P G +Y
Sbjct: 265 EGILAGISSGAAVAAALKLQEDESFTNKNIVVILPSSGERY 305
>sp|P55708|Y4XP_RHISN PUTATIVE CYSTEINE SYNTHASE (O-ACETYLSERINE SULFHYDRYLASE)
(O-ACETYLSERINE (THIOL)-LYASE) (CSASE)
>gi|2182724|gb|AAB91939.1| (AE000106) Y4xP [Rhizobium
sp. NGR234]
Length = 336
Score = 91.7 bits (224), Expect = 9e-18
Identities = 92/283 (32%), Positives = 134/283 (46%), Gaps = 28/283 (9%)
Query: 5 KLEFFNPFSRSIKDRAVYNMLIKALRSGEIDGTNVLYEATSGNVGISIAALSAVFGLKFR 64
K+E NP S+KDR +M+I AL+ G + + E++SGN G +A + FGL+F
Sbjct: 30 KIEKNNP-GGSMKDRMARSMVIAALQDGRLPPGGTIVESSSGNTGTGLALAALEFGLRFI 88
Query: 65 AYIPKPTPKTTELLIKVFGAEV--VRTNFDTIDKKFVE----FVKLEARRDKALNLNQFE 118
A + +++ GAE+ V +F + VE +L A+ AL +NQ +
Sbjct: 89 AVVDHHAAPDKIRMMRALGAEIRYVEGDFREDEVAVVERQRLAAQLGAQLPGALFMNQSD 148
Query: 119 NDANFEAHYYGTARELEEQLRSIDKIPEIIIAGIGTSGHIAGISKYFKERY-ETKIIGVV 177
N AN E Y G EL QL D I + + +GT G + GIS+ K + I V
Sbjct: 149 NPANPEG-YTGLVDELVAQLP--DGI-DAFVGCVGTGGSMTGISQRLKRNNPAVRTIAVE 204
Query: 178 PAKG-----------ETIPGIKRLETRPKWFFKVEVDEVVEVTAREAFEGILKVARSDGL 226
PA ++ G + K +DE V+VT +AFE +AR GL
Sbjct: 205 PAGSIVFGKPGHPYYQSGTGTPAGDEVGKVLDYGCIDEGVQVTDTQAFETARYIARRKGL 264
Query: 227 LIGMSS-GAVVKAYEKV---RPEGTTVLIFPDDGFKY-GEIFE 264
L+G S+ GA+ KA E + + GT V D G KY G IF+
Sbjct: 265 LVGGSTGGAIYKALEFIGAGKLTGTVVTTVADGGEKYLGTIFD 307
>gb|AAD53158.1|AF176824_1 (AF176824) O-acetylserine(thiol)-lyase SrpD [Synechococcus PCC7942]
Length = 329
Score = 91.3 bits (223), Expect = 1e-17
Identities = 81/271 (29%), Positives = 125/271 (45%), Gaps = 20/271 (7%)
Query: 5 KLEFFNPFSRSIKDRAVYNMLIKALRSGEIDGTNVLYEATSGNVGISIAALSAVFGLKFR 64
KLE+ NP S+KDR +++ A G I L E T+GN GI +A +A L+
Sbjct: 36 KLEYLNPLG-SVKDRTALSLIQSARSQGLITAGTTLIEPTTGNTGIGLAFAAAAEQLRLI 94
Query: 65 AYIPKPTPKTTELLIKVFGAEVVRT-NFDTIDKKFVEFVKLEARRDKALNLNQFENDANF 123
+P L K+ GA+VV T + + + L+ + ++ L QF+N AN
Sbjct: 95 LVMPDRVSAERIRLAKLLGAKVVLTPAAEAMLGCIAKAQALQQQIPDSVILQQFQNPANP 154
Query: 124 EAHYYGTARELEEQLRSIDKIPEIIIAGIGTSGHIAGISKYFKE-RYETKIIGVVPAKGE 182
H T E+ R D +I++AG+GT G + GIS+Y K R + I V PA+
Sbjct: 155 SIHQATTGPEI---WRDTDGEVDIVVAGVGTGGTLMGISRYLKPLRPRLQSIAVQPARSP 211
Query: 183 TI----PGIKRLETRPKWFF-----KVEVDEVVEVTAREAFEGILKVARSDGLLIGMSSG 233
+ G +L F + +DE++ +A I A +G+ +G+SSG
Sbjct: 212 VLSGGAAGSHQLTGMGPNFVSPLVDRSLIDEILSAYEEDAIAVIRTCAAREGIPLGVSSG 271
Query: 234 AVVKAYEKV--RPEGT---TVLIFPDDGFKY 259
A+V A +V RPE V + P +Y
Sbjct: 272 AIVWAALQVAKRPENAGKRIVAVCPSGSERY 302
>sp|P87131|CYSK_SCHPO PUTATIVE CYSTEINE SYNTHASE (O-ACETYLSERINE SULFHYDRYLASE)
(O-ACETYLSERINE (THIOL)-LYASE) (CSASE)
>gi|7492501|pir||T38685 probable cysteine synthase (EC
4.2.99.8) SPAC3A12.17c [similarity] - fission yeast
(Schizosaccharomyces pombe) >gi|2104433|emb|CAB08745.1|
(Z95395) putative cysteine synthase [Schizosaccharomyces
pombe]
Length = 395
Score = 90.5 bits (221), Expect = 2e-17
Identities = 90/302 (29%), Positives = 128/302 (41%), Gaps = 51/302 (16%)
Query: 4 AKLEFFNPFSRSIKDRAVYNMLIKALRSGEIDG--TNVLYEATSGNVGISIAALSAVFGL 61
AK EF NP S KDR M+ A +G++ +N +YE T+G+ GISIA L G
Sbjct: 71 AKAEFLNP-GNSPKDRVALQMIRTAEENGDLVPYQSNAVYEGTAGSTGISIAMLCCSLGY 129
Query: 62 KFRAYIPKPTPKTTELLIKVFGAEVVRTN----------FDTIDKKFVEFVKLEARRDKA 111
R Y+P K ++++ GA V R +T + E+ K
Sbjct: 130 DSRIYMPSDQSKEKSDILELLGAHVQRVTPAPIVDPNHFVNTARRNAANHTVDESIPGKG 189
Query: 112 LNLNQFENDANFEAHYYGTARELEEQLRSIDKIPEIIIAGIGTSGHIAGISKYFKER--- 168
NQFEN AN++AH+ T E+ Q K+ + IAG GT G IAGIS+Y K +
Sbjct: 190 YFANQFENPANWQAHFNSTGPEIWRQCAG--KL-DAFIAGSGTGGTIAGISRYLKSKDPS 246
Query: 169 -------------YETKIIGVVPAKGE-----------TI---PGIKRLETRPKWFFKVE 201
Y + GV+ E TI GI R+ TR +
Sbjct: 247 ITVCLADPPGSGLYHKVLHGVMFDLAEREGTRRRHQVDTIVEGVGINRM-TRNFSIAEPL 305
Query: 202 VDEVVEVTAREAFEGILKVARSDGLLIGMSSG----AVVKAYEKVRPEGTTVLIFPDDGF 257
+D VT +A + DGL +G SS A V+ +K+ P V + D G
Sbjct: 306 IDMAYRVTDEQAVAMSRYLVTHDGLFVGSSSAVNCVAAVRLAKKLGPGHRIVTLLCDPGS 365
Query: 258 KY 259
++
Sbjct: 366 RH 367
>gb|AAF35961.1| (AC024136) contains similarity to SW:CBS_RAT [Caenorhabditis
elegans]
Length = 755
Score = 90.5 bits (221), Expect = 2e-17
Identities = 85/285 (29%), Positives = 132/285 (45%), Gaps = 35/285 (12%)
Query: 3 FAKLEFFNPFSRSIKDRAVYNMLIKALRSGE----IDGTNVLYEATSGNVGISIAALSAV 58
+ K EF N S KDR M+ A ++G+ G L E TSGN GI ++ ++AV
Sbjct: 366 YVKCEFLNA-GGSTKDRIAKKMVEIAEKTGKPGALTPGATTLIEPTSGNTGIGLSLVAAV 424
Query: 59 FGLKFRAYIPKPTPKTTELLIKVFGAEVVRT----NFDTIDKKFVEFVKLEARRDKALNL 114
G K +P+ K + V G+ +VRT F++ ++L+ A+ L
Sbjct: 425 RGYKCLITMPEKMSKEKSTTLSVLGSTIVRTPNEAAFNSPSSHIGVALRLKHEIPGAVIL 484
Query: 115 NQFENDANFEAHYYGTARELEEQLRSIDKIPEIIIAGIGTSGHIAGISKYFKERYETKII 174
+Q+ N N AHY TA E+ + D+ ++++ G GT G I GIS+ ER I+
Sbjct: 485 DQYCNPGNPLAHYEETAEEILWDMG--DRKIDLVVLGAGTGGTITGISRKIHERRPNAIV 542
Query: 175 GVVPAKGETIPGIKRLETRP-KWFFKVE---------------VDEVVEVTAREAFEGIL 218
V G + G T P F++VE VD ++ +E+F
Sbjct: 543 VGVDPNGSILTG---PTTGPAPDFYEVEGIGYDFIPGTLDEKSVDSWLKSDDKESFLMAR 599
Query: 219 KVARSDGLLIGMSSG-AVVKAYEKVR----PEGTTVLIFPDDGFK 258
++ R++G+L G SSG AV A E+ R PE V++ DG +
Sbjct: 600 EIIRTEGILCGGSSGCAVHYALEQCRKLDLPEDANVVVLLPDGIR 644
>sp|P12674|CYSK_SALTY CYSTEINE SYNTHASE A (O-ACETYLSERINE SULFHYDRYLASE A)
(O-ACETYLSERINE (THIOL)-LYASE A) (CSASE A)
>gi|68323|pir||SYEBAC cysteine synthase (EC 4.2.99.8) A
- Salmonella typhimurium >gi|153935|gb|AAA27051.1|
(M21450) cysK protein [Salmonella typhimurium]
Length = 323
Score = 90.1 bits (220), Expect = 3e-17
Identities = 82/281 (29%), Positives = 127/281 (45%), Gaps = 29/281 (10%)
Query: 4 AKLEFFNPFSRSIKDRAVYNMLIKALRSGEIDGTNVLYEATSGNVGISIAALSAVFGLKF 63
AK+E NP S S+K R NM+ A + G + L E T+GN GI++A ++A G K
Sbjct: 30 AKVESRNP-SFSVKCRIGANMIWDAEKRGVLKPGVELVEPTNGNTGIALAYVAAARGYKL 88
Query: 64 RAYIPKPTPKTTELLIKVFGAEVVRTNFDTIDKKFVEFVKLEARRD--KALNLNQFENDA 121
+P+ L+K GA +V T K ++ + D K L L QF N A
Sbjct: 89 TLTMPETMSIERRKLLKALGANLVLTEGAKGMKGAIQKAEEIVASDPQKYLLLQQFSNPA 148
Query: 122 NFEAHYYGTARELEEQLRSIDKIPEIIIAGIGTSGHIAGISKYFK-------------ER 168
N E H T E+ E D ++ I+G+GT G + G+++Y K E
Sbjct: 149 NPEIHEKTTGPEIWE---DTDGQVDVFISGVGTGGTLTGVTRYIKGTKGKTDLITVAVEP 205
Query: 169 YETKIIGVVPAKGETIPGIKRLETRPKWFFKVE-----VDEVVEVTAREAFEGILKVARS 223
++ +I A E PG +++ F +D+VV +T EA ++
Sbjct: 206 TDSPVIAQALAGEEIKPGPHKIQGIGAGFIPGNLDLKLIDKVVGITNEEAISTARRLMEE 265
Query: 224 DGLLIGMSSGAVVKAYEKVRPEGT-----TVLIFPDDGFKY 259
+ L G+SSGA V A K++ + + V+I P G +Y
Sbjct: 266 EVFLAGISSGAAVAAALKLQEDESFTNKNIVVILPSSGERY 306
>pir||T19367 cysteine synthase (EC 4.2.99.8) C17G1.7 [similarity] -
Caenorhabditis elegans >gi|3874359|emb|CAB01676.1|
(Z78415) Similarity to Wheat cysteine synthase
(SW:CYSK_WHEAT), contains similarity to Pfam domain:
PF00291 (Pyridoxal-phosphate dependent enzyme),
Score=444.4, E-value=3.2e-130, N=1~cDNA EST yk157a8.3
comes from this gene~cDNA EST yk184d7.3 comes from>
Length = 344
Score = 90.1 bits (220), Expect = 3e-17
Identities = 80/278 (28%), Positives = 131/278 (46%), Gaps = 33/278 (11%)
Query: 5 KLEFFNPFSRSIKDRAVYNMLIKALRSGE-IDGTNVLYEATSGNVGISIAALSAVFGLKF 63
K+E+ NP + S+KDR ML A + G I G L E TSGN GI++A ++A G +
Sbjct: 40 KIEYMNP-AGSVKDRIGAAMLAAAEKDGTVIPGVTTLIEPTSGNTGIALAFVAAAKGYRC 98
Query: 64 RAYIPKPTPKTTELLIKVFGAEVVRTNFDTIDKKFVEFV-KLEARRDKALNLNQFENDAN 122
+P L+K +G+EVV T+ K ++ +L+ ++ L QF+N N
Sbjct: 99 IVTMPASMSGERRTLLKAYGSEVVLTDPAKGMKGAIDMANQLKENIPGSIILAQFDNPNN 158
Query: 123 FEAHYYGTARELEEQLRSIDKIPEIIIAGIGTSGHIAGISKYFKERYE-TKIIGVVPAKG 181
HY T E+ Q + + ++ G+GT G I G+ +Y +E+ ++ V P +
Sbjct: 159 PLVHYQTTGPEIWRQTKG---TVDAVVFGVGTGGTITGVGRYLQEQNPGVRVFAVEPEES 215
Query: 182 ETIPGIKRLETRPKWFFKVE---------------VDEVVEVTAREAFEGILKVARSDGL 226
+ G RP K++ ++V+ + + EA +++ +GL
Sbjct: 216 AILSG------RPAGPHKIQGIGAGFAPAVLDTKIYEDVIRIHSDEAIVMAQRLSYEEGL 269
Query: 227 LIGMSSGAVVKAYEKV--RPEGTTVLI---FPDDGFKY 259
L G+SSGA V A ++ RPE LI P G +Y
Sbjct: 270 LGGISSGANVAAALQLAARPEMAGKLIVTCLPSCGERY 307
>dbj|BAA88310.1| (AB028865) O-acetylserine lyase [Streptococcus suis]
Length = 308
Score = 90.1 bits (220), Expect = 3e-17
Identities = 77/271 (28%), Positives = 122/271 (44%), Gaps = 17/271 (6%)
Query: 3 FAKLEFFNPFSRSIKDRAVYNMLIKALRSGEIDGTNVLYEATSGNVGISIAALSAVFGLK 62
+ KLE FNP S S+KDR M+ A ++G I + + E TSGN GI +A + A G
Sbjct: 31 YVKLEAFNPGS-SVKDRIALAMIEDAEKAGTIKPGDTIVEPTSGNTGIGLAWVGAAKGYN 89
Query: 63 FRAYIPKPTPKTTELLIKVFGAEVVRTNFDTIDKKFVEFVKLEARRDKALNLNQFENDAN 122
+P+ +I+ +GAE+V T K + K A QF N +N
Sbjct: 90 VIIVMPETMSVERRKIIQAYGAELVLTPGSEGMKGAIAKAKEIAEEKNGWVPFQFANPSN 149
Query: 123 FEAHYYGTARELEEQLRSIDKIPEIIIAGIGTSGHIAGISKYFKERYETKIIGVVPAKGE 182
+ H T +E+ E + + ++G+GT G ++G+S K I V A
Sbjct: 150 PKVHEDTTGQEILEDFGTTGL--DAFVSGVGTGGTVSGVSHVLKTANPDIAIYAVEADES 207
Query: 183 TI-----PGIKRLETRPKWFFKVEVDE-----VVEVTAREAFEGILKVARSDGLLIGMSS 232
+ PG +++ F +D ++ V + +A + +G L+G+SS
Sbjct: 208 AVLSGEAPGPHKIQGISAGFIPDTLDTSAYDGIIRVKSDDALATGRAIGGKEGFLVGISS 267
Query: 233 GAVVKAYEKVRPE---GTTVL-IFPDDGFKY 259
GA + A +V E G VL I PD+G +Y
Sbjct: 268 GAAIHAAIEVAKELGTGKKVLAILPDNGERY 298
>pir||E83306 cysteine synthase A PA2709 [imported] - Pseudomonas aeruginosa
(strain PAO1) >gi|9948784|gb|AAG06097.1|AE004699_2
(AE004699) cysteine synthase A [Pseudomonas aeruginosa]
Length = 324
Score = 89.7 bits (219), Expect = 3e-17
Identities = 84/294 (28%), Positives = 131/294 (43%), Gaps = 30/294 (10%)
Query: 4 AKLEFFNPFSRSIKDRAVYNMLIKALRSGEIDGTNVLYEATSGNVGISIAALSAVFGLKF 63
AK+E NP S+K R NM+ A SG + L E TSGN GI +A ++A G K
Sbjct: 32 AKIEGRNP-GYSVKCRIGANMIWDAEASGRLKSGMTLVEPTSGNTGIGLAFVAAARGYKL 90
Query: 64 RAYIPKPTPKTTELLIKVFGAEVVRTNFDTIDKKFVEFVKLEARRD--KALNLNQFENDA 121
+P ++K GAE+V T K ++ + D K QF+N A
Sbjct: 91 ILTMPASMSLERRKVLKALGAELVLTEPAKGMKGAIQKAEELVAGDPGKYFMPQQFDNPA 150
Query: 122 NFEAHYYGTARELEEQLRSIDKIPEIIIAGIGTSGHIAGISKYFKERYETKIIGVV---- 177
N H T E+ + +++++G+GT G + G+S+Y K I+ V
Sbjct: 151 NPAIHEKTTGPEI---WNDTEGAVDVLVSGVGTGGTLTGVSRYIKNTRGKPILAVAVEPV 207
Query: 178 --PAKGETIPG--IKRLETR---------PKWFFKVEVDEVVEVTAREAFEGILKVARSD 224
P +T+ G +K + PK VD V ++ EA L++ + +
Sbjct: 208 TSPVISQTLAGEEVKPAPHKIQGIGAGFVPKNLDLSLVDRVEKIGDDEAKNMALRLMQEE 267
Query: 225 GLLIGMSSGAVVKAYEKVRPE-----GTTVLIFPDDGFKY--GEIFEMLLGEAQ 271
G+L G+SSGA + A ++ E T V+I PD G +Y +F+ L E +
Sbjct: 268 GILCGISSGAAMAAAVRLAEEPNMQGKTIVVILPDSGERYLSSMLFDGLFSEQE 321
>gb|AAB65342.1| (AF016425) Contains similarity to Pfam domain: PF00291
(S_T_dehydratase), Score=239.5, E-value=1.5e-68, N=1
[Caenorhabditis elegans]
Length = 337
Score = 88.9 bits (217), Expect = 6e-17
Identities = 84/286 (29%), Positives = 140/286 (48%), Gaps = 27/286 (9%)
Query: 5 KLEFFNPFSRSIKDRAVYNMLIKALRSGEI-DGTNVLYEATSGNVGISIAALSAVFGLKF 63
K+E+ NP S S+KDR M+ A ++G+I G VL E TSGN+GI++A + + G K
Sbjct: 36 KIEYLNP-SCSVKDRIAKTMVDDAEKAGKIVPGKTVLVEGTSGNLGIALAHIGRIRGYKV 94
Query: 64 RAYIPKPTPKTTELLIKVFGAEVVRTNFDTIDKKFVEFVK-LEARRDKALNLNQFENDAN 122
+ +++ +GAEV+ ++ V+ ++ L ++ A L+QF N +N
Sbjct: 95 ILVMTTAMSIERRAMLRAYGAEVILSDPAEGHPGIVKKIEMLVSKLPDAYCLDQFSNPSN 154
Query: 123 FEAHYYGTARELEEQLRSIDKIPEIIIAGIGTSGHIAGISKYFK-----------ERYET 171
AHY T E+ +Q + K+ +++ G+G+ G + G+ +Y + E +E+
Sbjct: 155 PAAHYRTTGPEIWKQTQG--KV-DMVCFGVGSGGTVTGVGRYLRAQKQNIGVYPVEPFES 211
Query: 172 KIIGVVPAKGETIPGIKRLETRPKWFFKVEVDEVVEVTAREAFEGILKVARSDGLLIGMS 231
++ P I GI P + EV V + +A + ++A + +L G+S
Sbjct: 212 SVLSGFPRGPHKIHGI-GAGLIPGNVDRSLFTEVFRVKSEDAMKMARRLADEEAILGGIS 270
Query: 232 SGA-VVKAYEKV-RPEG------TTVLIFPDDGFKYGEIFEMLLGE 269
SGA VV A E RPE TTV F + F E++ LL E
Sbjct: 271 SGANVVAAVELARRPENIGKLIVTTVNSFAERYFS-TELYSTLLSE 315
>gb|AAF37822.1|AF192489_1 (AF192489) cysteine sulfhydrylase [Salmonella ohio]
Length = 323
Score = 87.0 bits (212), Expect = 2e-16
Identities = 80/281 (28%), Positives = 127/281 (44%), Gaps = 29/281 (10%)
Query: 4 AKLEFFNPFSRSIKDRAVYNMLIKALRSGEIDGTNVLYEATSGNVGISIAALSAVFGLKF 63
AK+E NP S S+K R NM+ A + G + L E TSGN GI++A ++A G K
Sbjct: 30 AKVESRNP-SFSVKCRIGANMIWDAEKRGVLKPGVELVEPTSGNTGIALAYVAAGRGYKL 88
Query: 64 RAYIPKPTPKTTELLIKVFGAEVVRTNFDTIDKKFVEFVK--LEARRDKALNLNQFENDA 121
+P+ L+K GA +V T K ++ + + + R+K L L QF N A
Sbjct: 89 TLTMPETMSIERRKLLKALGANLVLTEGAKGMKGAIQKAEEIVASNREKFLLLQQFNNPA 148
Query: 122 NFEAHYYGTARELEEQLRSIDKIPEIIIAGIGTSGHIAGISKYFK-------------ER 168
N E H T E+ + D + I+G+G G + G+ ++ K E
Sbjct: 149 NPEIHEKNTGPEIWGE---TDGQVGLFISGVGAGGTLNGVGRFLKSPRGKKNLITVAGEP 205
Query: 169 YETKIIGVVPAKGETIPGIKRLETRPKWFFKVE-----VDEVVEVTAREAFEGILKVARS 223
++ +I A E PG +++ F VD+V+ +T EA ++
Sbjct: 206 TDSPVIPQALAGEELKPGPHKIQGIGAGFIPGNLDLKLVDKVIGITNEEAISTARRLMEE 265
Query: 224 DGLLIGMSSGAVVKAYEKVRPE-----GTTVLIFPDDGFKY 259
+G+L G+SSGA V A K++ + V+ P G +Y
Sbjct: 266 EGILAGISSGAAVAAALKLQEDEAFTNKNIVVTLPSPGERY 306
>emb|CAA88980.2| (Z49131) contains similarity to Pfam domain: PF00291
(Pyridoxal-phosphate dependent enzyme), Score=546.2,
E-value=7.3e-161, N=2~cDNA EST yk62d8.5 comes from this
gene~cDNA EST yk62d8.3 comes from this gene~cDNA EST
yk82a7.3 comes from this gene~cDNA ES>
>gi|6580347|emb|CAB63415.1| (Z72518) contains similarity
to Pfam domain: PF00291 (Pyridoxal-phosphate dependent
enzyme), Score=546.2, E-value=7.3e-161, N=2~cDNA EST
yk62d8.5 comes from this gene~cDNA EST yk62d8.3 comes
from this gene~cDNA EST yk82a7.3 comes from this
gene~cDNA ES>
Length = 700
Score = 86.2 bits (210), Expect = 4e-16
Identities = 82/282 (29%), Positives = 133/282 (47%), Gaps = 38/282 (13%)
Query: 3 FAKLEFFNPFSRSIKDRAVYNMLIKALRSGE----IDGTNVLYEATSGNVGISIAALSAV 58
+ K E+ N S KDR M+ A ++G+ + G ++ E TSGN GI ++ SAV
Sbjct: 404 YVKCEYMNA-GGSTKDRIAKRMVEIAEKTGKPGKLVPGVTLI-EPTSGNTGIGLSLASAV 461
Query: 59 FGLKFRAYIPKPTPKTTELLIKVFGAEVVRT----NFDTIDKKFVEFVKLEARRDKALNL 114
G K +PK K + + G+ ++RT FD+ ++L++ A+ L
Sbjct: 462 RGYKCIITMPKKMSKEKSIAMASLGSTIIRTPNEAGFDSPHSHIGVALRLKSEIQDAVVL 521
Query: 115 NQFENDANFEAHYYGTARELEEQLRSIDKIPEIIIAGIGTSGHIAGISKYFKERYET-KI 173
+Q+ N N AHY TA E+ + DK ++++ GT G + GIS+ ER T K+
Sbjct: 522 DQYCNPGNPLAHYEETAEEIIYDMG--DKHIDLVVLTAGTGGTVTGISRKIHERIPTAKV 579
Query: 174 IGVVPAKGETIPGIKRLETRPKWFFKVE---------------VDEVVEVTAREAFEGIL 218
+GV P G + G + F++VE +D + +E+F
Sbjct: 580 VGVDP-HGSILAGPAETDID---FYEVEGIGYDFLPGTLDTSAIDYWAKSHDKESFLMAR 635
Query: 219 KVARSDGLLIGMSSG-AVVKAYEKVR-----PEGTTVLIFPD 254
++ RS+G+L G SSG AV A E+ + E V++ PD
Sbjct: 636 ELIRSEGILCGGSSGCAVHYALEECKSLNLPAEANVVVLLPD 677
Score = 83.1 bits (202), Expect = 3e-15
Identities = 75/263 (28%), Positives = 128/263 (48%), Gaps = 14/263 (5%)
Query: 3 FAKLEFFNPFSRSIKDRAVYNMLIKALRSGEIDGTNVLYEATSGNVGISIAALSAVFGLK 62
+ KLE+ N + S++DR A G + G V A G+ IS A ++AV G+K
Sbjct: 45 YVKLEYLN-IAGSLEDRTADKAFQFAEEIGVVRGDEVFVTA-GGSAAISYATVAAVKGIK 102
Query: 63 FRAYIPKPTPKTTELLIKVFGAEVVRTNFDTIDKKFVEFVKLEARRDKALNLNQFENDAN 122
Y PK + ++ G + V F T + V+ A++ +LN+F +A
Sbjct: 103 LTIYAPKGEFDLVDTVLHTLGVKTVELPFGTFAEARVQ-TDEAAQQKGVFSLNKFTTNAA 161
Query: 123 FEAHYYGTARELEEQL--RSIDKIPEIIIAGIGTSGHIAGISKYFK--ERYETKIIGVVP 178
F A+ TA E+E+ + +SI K+ ++I + T AGI+ Y+K + +++GV
Sbjct: 162 FVANLQKTALEIEKAVNNKSIGKVGAVVIP-LNTGAAAAGIAAYYKGIGEHGVRVVGVT- 219
Query: 179 AKGETIPGIKRLETRPKWFFKVEVDEVVEVTAREAFEGILKVARSDGLLIGMSSGAVVKA 238
K +TIP + L+ + + V E EV EA+ + ++G++ G SSGA V
Sbjct: 220 CKKDTIPEM-GLDLKNDLLQEYNV-EKREVEEDEAYSFTRHLIGTEGIMAGPSSGAAVLE 277
Query: 239 YEKVR---PEGTTVLIFPDDGFK 258
K+ P G+T+++ DG +
Sbjct: 278 AIKLAKELPAGSTIVVVLMDGIR 300
>pir||T27526 hypothetical protein ZC373.1 - Caenorhabditis elegans (fragment)
Length = 696
Score = 86.2 bits (210), Expect = 4e-16
Identities = 82/282 (29%), Positives = 133/282 (47%), Gaps = 38/282 (13%)
Query: 3 FAKLEFFNPFSRSIKDRAVYNMLIKALRSGE----IDGTNVLYEATSGNVGISIAALSAV 58
+ K E+ N S KDR M+ A ++G+ + G ++ E TSGN GI ++ SAV
Sbjct: 400 YVKCEYMNA-GGSTKDRIAKRMVEIAEKTGKPGKLVPGVTLI-EPTSGNTGIGLSLASAV 457
Query: 59 FGLKFRAYIPKPTPKTTELLIKVFGAEVVRT----NFDTIDKKFVEFVKLEARRDKALNL 114
G K +PK K + + G+ ++RT FD+ ++L++ A+ L
Sbjct: 458 RGYKCIITMPKKMSKEKSIAMASLGSTIIRTPNEAGFDSPHSHIGVALRLKSEIQDAVVL 517
Query: 115 NQFENDANFEAHYYGTARELEEQLRSIDKIPEIIIAGIGTSGHIAGISKYFKERYET-KI 173
+Q+ N N AHY TA E+ + DK ++++ GT G + GIS+ ER T K+
Sbjct: 518 DQYCNPGNPLAHYEETAEEIIYDMG--DKHIDLVVLTAGTGGTVTGISRKIHERIPTAKV 575
Query: 174 IGVVPAKGETIPGIKRLETRPKWFFKVE---------------VDEVVEVTAREAFEGIL 218
+GV P G + G + F++VE +D + +E+F
Sbjct: 576 VGVDP-HGSILAGPAETDID---FYEVEGIGYDFLPGTLDTSAIDYWAKSHDKESFLMAR 631
Query: 219 KVARSDGLLIGMSSG-AVVKAYEKVR-----PEGTTVLIFPD 254
++ RS+G+L G SSG AV A E+ + E V++ PD
Sbjct: 632 ELIRSEGILCGGSSGCAVHYALEECKSLNLPAEANVVVLLPD 673
Score = 83.1 bits (202), Expect = 3e-15
Identities = 75/263 (28%), Positives = 128/263 (48%), Gaps = 14/263 (5%)
Query: 3 FAKLEFFNPFSRSIKDRAVYNMLIKALRSGEIDGTNVLYEATSGNVGISIAALSAVFGLK 62
+ KLE+ N + S++DR A G + G V A G+ IS A ++AV G+K
Sbjct: 41 YVKLEYLN-IAGSLEDRTADKAFQFAEEIGVVRGDEVFVTA-GGSAAISYATVAAVKGIK 98
Query: 63 FRAYIPKPTPKTTELLIKVFGAEVVRTNFDTIDKKFVEFVKLEARRDKALNLNQFENDAN 122
Y PK + ++ G + V F T + V+ A++ +LN+F +A
Sbjct: 99 LTIYAPKGEFDLVDTVLHTLGVKTVELPFGTFAEARVQ-TDEAAQQKGVFSLNKFTTNAA 157
Query: 123 FEAHYYGTARELEEQL--RSIDKIPEIIIAGIGTSGHIAGISKYFK--ERYETKIIGVVP 178
F A+ TA E+E+ + +SI K+ ++I + T AGI+ Y+K + +++GV
Sbjct: 158 FVANLQKTALEIEKAVNNKSIGKVGAVVIP-LNTGAAAAGIAAYYKGIGEHGVRVVGVT- 215
Query: 179 AKGETIPGIKRLETRPKWFFKVEVDEVVEVTAREAFEGILKVARSDGLLIGMSSGAVVKA 238
K +TIP + L+ + + V E EV EA+ + ++G++ G SSGA V
Sbjct: 216 CKKDTIPEM-GLDLKNDLLQEYNV-EKREVEEDEAYSFTRHLIGTEGIMAGPSSGAAVLE 273
Query: 239 YEKVR---PEGTTVLIFPDDGFK 258
K+ P G+T+++ DG +
Sbjct: 274 AIKLAKELPAGSTIVVVLMDGIR 296
>sp|Q59966|SRPG_SYNP7 CYSTEINE SYNTHASE, PLASMID (O-ACETYLSERINE SULFHYDRYLASE)
(O-ACETYLSERINE (THIOL)-LYASE) (CSASE)
>gi|1084168|pir||S55321 cysteine synthase (EC 4.2.99.8)
- Synechococcus sp. (strain PCC 7942) plasmid pANL
>gi|790254|gb|AAA86725.1| (U23436)
O-acetyl-L-serine(thiol)-lyase A [Synechococcus PCC7942]
Length = 329
Score = 85.8 bits (209), Expect = 5e-16
Identities = 82/288 (28%), Positives = 132/288 (45%), Gaps = 44/288 (15%)
Query: 4 AKLEFFNPFSRSIKDRAVYNMLIKALRSGEIDGTNVLYEATSGNVGISIAALSAVFGLKF 63
AK+E NP + S+K R M+ A + G + L E TSGN GI++A ++A G+
Sbjct: 36 AKIEGRNP-AYSVKCRIGAAMIWDAEQRGLLGPGKELIEPTSGNTGIALAFVAAARGIPL 94
Query: 64 RAYIPKPTPKTTELLIKVFGAEVVRTNFDTIDKKFVEFVKLEARR---------DKALNL 114
+P+ L+ +GA++V T + V+ + RR D+ + L
Sbjct: 95 TLTMPETMSLERRKLLAAYGAKLVLT-------EGVKGMTGAVRRAEDIAASDPDRYVLL 147
Query: 115 NQFENDANFEAHYYGTAREL-EEQLRSIDKIPEIIIAGIGTSGHIAGISKYFKERYETKI 173
QF N AN H T E+ E+ +ID I+++G+GT G I G+S+Y K+ I
Sbjct: 148 QQFRNPANPAIHEQTTGPEIWEDTGGAID----ILVSGVGTGGTITGVSRYIKQTQGKPI 203
Query: 174 IGVV--PAKGETI----------PGIKRLETRPKWFFKVE-----VDEVVEVTAREAFEG 216
+ V P I PG +++ F VD+V V+ EA
Sbjct: 204 LSVAVEPEASPVISQQRSGLPLKPGPHKIQGIGAGFIPENLDLSLVDQVERVSNEEAIAY 263
Query: 217 ILKVARSDGLLIGMSSGAVVKAYEKVRPEG-----TTVLIFPDDGFKY 259
++A+ +GL+ G+S GA V A ++ + T V++ PD G +Y
Sbjct: 264 ARRLAQEEGLISGISCGAAVAAAVRLAQQSEHAGKTIVVVLPDSGERY 311
>pir||C70894 probable cystathionine beta-synthase (EC 4.2.1.22) cysM2 Rv1077
[similarity] - Mycobacterium tuberculosis (strain H37RV)
>gi|2896714|emb|CAA17193.1| (AL021897) cysM2
[Mycobacterium tuberculosis]
Length = 464
Score = 85.4 bits (208), Expect = 7e-16
Identities = 79/299 (26%), Positives = 129/299 (42%), Gaps = 35/299 (11%)
Query: 4 AKLEFFNPFSRSIKDRAVYNMLIKALRSGEIDGTNVLYEATSGNVGISIAALSAVFGLKF 63
AK+E+ NP S KDR M+ A SG++ + E TSGN G+ +A ++ G K
Sbjct: 32 AKVEYLNPGGSS-KDRIAVKMIEAAEASGQLKPGGTIVEPTSGNTGVGLALVAQRRGYKC 90
Query: 64 RAYIPKPTPKTTELLIKVFGAEVV----------RTNFDTIDKKFVEFVKLEARRDKALN 113
P + ++ +GAEVV ++ ++ + V + D A
Sbjct: 91 VFVCPDKVSEDKRNVLIAYGAEVVVCPTAVPPHDPASYYSVSDRLVRDI------DGAWK 144
Query: 114 LNQFENDANFEAHYYGTARELEEQLRSIDKIPEIIIAGIGTSGHIAGISKYFKE--RYET 171
+Q+ N +HY T E+ K+ +AGIGT G I G +Y KE
Sbjct: 145 PDQYANPEGPASHYVTTGPEIWADTEG--KVTH-FVAGIGTGGTITGAGRYLKEVSGGRV 201
Query: 172 KIIGVVPAKGETIPGIKR--------LETRPKWFFKVEVDEVVEVTAREAFEGILKVARS 223
+I+G P G R + P + DE++ V+ ++F+ ++AR
Sbjct: 202 RIVGADPEGSVYSGGAGRPYLVEGVGEDFWPAAYDPSVPDEIIAVSDSDSFDMTRRLARE 261
Query: 224 DGLLIGMSSG----AVVKAYEKVRPEGTTVLIFPDDGFKY-GEIFEMLLGEAQGKISSR 277
+ +L+G S G A +K E+ P+ V++ PD G Y +IF + G + SR
Sbjct: 262 EAMLVGGSCGMAVVAALKVAEEAGPDALIVVLLPDGGRGYMSKIFNDAWMSSYGFLRSR 320
>sp|Q44004|CYSM_ALCEU CYSTEINE SYNTHASE (O-ACETYLSERINE SULFHYDRYLASE) (O-ACETYLSERINE
(THIOL)-LYASE) (CSASE) >gi|1296433|emb|CAA66130.1|
(X97499) O-acetylserine sulfhydrylase B [Ralstonia sp.
CH34]
Length = 339
Score = 85.0 bits (207), Expect = 9e-16
Identities = 53/181 (29%), Positives = 100/181 (54%), Gaps = 12/181 (6%)
Query: 3 FAKLEFFNPFSRSIKDRAVYNMLIKALRSGEIDGTNVLYEATSGNVGISIAALSAVFGLK 62
FAKLE NP + S+KDR ++ K L G I + + E++SGN+ I++A + + GL+
Sbjct: 30 FAKLELLNP-AGSVKDRPARYIVEKGLTEGAIGPHSHVIESSSGNLAIALAMICGLKGLR 88
Query: 63 FRAYIPKPTPKTTELLIKVFGAEVVRTNFDTIDKKFVEF------VKLEARRDKALNLNQ 116
F A + T +++ +GA + + ++E L +RD A+ +NQ
Sbjct: 89 FTAVVDPKISPTNLKILRCYGAGIEQVTAKDSQGGYLETRIERVRQMLREQRD-AIWINQ 147
Query: 117 FENDANFEAHYYGTARELEEQLRSIDKIPEIIIAGIGTSGHIAGISKYFKERYET-KIIG 175
+ N N+E+HYYG A E+ L + + ++++ G+ TSG + GI++ ++ + + +++G
Sbjct: 148 YANPLNWESHYYGEAAEI---LAHVAQPADVLVLGVTTSGTVHGIARRLRKAWPSMRVVG 204
Query: 176 V 176
V
Sbjct: 205 V 205
>dbj|BAA85111.1| (AB031004) O-acetylserine (thiol) lyase 2 [Cyanidioschyzon merolae]
Length = 390
Score = 83.5 bits (203), Expect = 3e-15
Identities = 76/283 (26%), Positives = 121/283 (41%), Gaps = 34/283 (12%)
Query: 3 FAKLEFFNPFSRSIKDRAVYNMLIKALRSGEIDGTNVLYEATSGNVGISIAALSAVFGLK 62
+ K EF P S+KDRA +L A + G + +++ E T+GN GI + L G +
Sbjct: 77 YGKAEFMEP-GGSVKDRAALYLLTDAEKRGTLKLGSIVVEGTAGNTGIGLTLLGNSRGYR 135
Query: 63 FRAYIPKPTPKTTELLIKVFGAEVVRTNFDTIDKKFVEFVKLEARRDKALN---LNQFEN 119
IP+ + + ++ GAE+V+ + +V+L R K L NQF+N
Sbjct: 136 TVIVIPETQSEEKKEFLRSCGAELVQVPAAPY-RNPNNYVRLSERLAKELGAFWANQFDN 194
Query: 120 DANFEAHYYGTARELEEQLRSIDKIPEIIIAGIGTSGHIAGISKYFKERYETKIIGVVPA 179
AN AH T E+ +QL D + +GT G +AG+S + + + I +
Sbjct: 195 PANRRAHEETTGPEIWDQL---DGHIDAFNCAVGTGGTLAGVSAFLRAKNPGIKIALTDP 251
Query: 180 KGETIP-------------------GIKRLETRPKWFFKVEVDEVVEVTAREAFEGILKV 220
+G + G R+ + F D E++ EA + V
Sbjct: 252 QGAALVRYYQCGELVSVGDSITEGIGQSRITGNLEGFVP---DMSFEISDAEALQAAYDV 308
Query: 221 ARSDGLLIGMSSG----AVVKAYEKVRPEGTTVLIFPDDGFKY 259
R +GL IG+SSG ++ E + P T V I D G +Y
Sbjct: 309 VRHEGLHIGLSSGINIAGAIRVAESLGPGHTIVTILCDGGSRY 351
>gi|6321449 Ygr012wp [Saccharomyces cerevisiae]
>gi|1706273|sp|P53206|CYSK_YEAST PUTATIVE CYSTEINE
SYNTHASE (O-ACETYLSERINE SULFHYDRYLASE) (O-ACETYLSERINE
(THIOL)-LYASE) (CSASE) >gi|2131641|pir||S64303 cysteine
synthase (EC 4.2.99.8) YGR012w [similarity] - yeast
(Saccharomyces cerevisiae) >gi|1322974|emb|CAA96995.1|
(Z72797) ORF YGR012w [Saccharomyces cerevisiae]
Length = 393
Score = 81.1 bits (197), Expect = 1e-14
Identities = 64/180 (35%), Positives = 91/180 (50%), Gaps = 21/180 (11%)
Query: 3 FAKLEFFNPFSRSIKDRAVYNMLIKALRSGEI--DGTNVLYEATSGNVGISIAALSAVFG 60
+AKLE NP + S KDR N++ A GE+ ++E TSG+ GISIA + G
Sbjct: 73 YAKLELCNP-AGSAKDRVALNIIKTAEELGELVRGEPGWVFEGTSGSTGISIAVVCNALG 131
Query: 61 LKFRAYIPKPTPKTTELLI----------KVFGAEVVRTN-FDTIDKKFVEFVKLEARRD 109
+RA+I P + E L KV A +V N + KK +K
Sbjct: 132 --YRAHISLPDDTSLEKLALLESLGATVNKVKPASIVDPNQYVNAAKKACNELKKSGNGI 189
Query: 110 KALNLNQFENDANFEAHYYGTARELEEQLR-SIDKIPEIIIAGIGTSGHIAGISKYFKER 168
+A+ +QFEN+AN++ HY T E+ Q + +ID IAG GT G I G++K+ KER
Sbjct: 190 RAVFADQFENEANWKVHYQTTGPEIAHQTKGNID----AFIAGCGTGGTITGVAKFLKER 245
>pir||D82758 cysteine synthase XF0831 [imported] - Xylella fastidiosa (strain
9a5c) >gi|9105733|gb|AAF83641.1|AE003922_11 (AE003922)
cysteine synthase [Xylella fastidiosa]
Length = 332
Score = 81.1 bits (197), Expect = 1e-14
Identities = 70/273 (25%), Positives = 122/273 (44%), Gaps = 21/273 (7%)
Query: 3 FAKLEFFNPFSRSIKDRAVYNMLIKALRSGEIDGTNVLYEATSGNVGISIAALSAVFGLK 62
+ K+E FNP S S+KDR +++ A + G + + + EATSGN G+++A ++A G
Sbjct: 43 YIKVESFNP-SGSVKDRLALAIILDAEQQGLLKPGDTIVEATSGNTGVALAMIAAARGYT 101
Query: 63 FRAYIPKPTPKTTELLIKVFGAEVVRTNFDTIDKKFVEFVKLEARRDKALNLNQFENDAN 122
F A + + L++ +GA+V+ T V K A + +QF N AN
Sbjct: 102 FVATMVETFSIERRKLMRAYGAKVILTPAAERGSGMVRKAKELAEQHGWFLASQFSNPAN 161
Query: 123 FEAHYYGTARELEEQL--RSIDKIPEIIIAGIGTSGHIAGISKYFK-ERYETKIIGVVPA 179
H TA E+ R +D ++G GT G + G+ + K R + I PA
Sbjct: 162 PAYHRNTTAAEILRDFAGRRLDH----FVSGWGTGGTLTGVGEVLKIARPDITITASEPA 217
Query: 180 KGETIPGIKRLETR---------PKWFFKVEVDEVVEVTAREAFEGILKVARSDGLLIGM 230
+ G + + P+ + ++ VT +A ++A +G+ G+
Sbjct: 218 SAALLQGKEWQPHKIQGWTPDFVPEVLNRSVPHHILSVTDDDAITVARRLAAEEGVFSGI 277
Query: 231 SSGAVV----KAYEKVRPEGTTVLIFPDDGFKY 259
S GA V + ++ +P + + PD G +Y
Sbjct: 278 SGGATVATALQIAQQAQPGAVILAMLPDTGERY 310
>pir||G83381 probable cysteine synthase PA2104 [imported] - Pseudomonas
aeruginosa (strain PAO1)
>gi|9948118|gb|AAG05492.1|AE004638_2 (AE004638) probable
cysteine synthase [Pseudomonas aeruginosa]
Length = 305
Score = 76.9 bits (186), Expect = 3e-13
Identities = 76/271 (28%), Positives = 117/271 (43%), Gaps = 21/271 (7%)
Query: 3 FAKLEFFNPFSRSIKDRAVYNMLIKALRSGEI---DGTNVLYEATSGNVGISIAALSAVF 59
FAKLE FNP S K R M++ A R G + G +L E + GN GI +A +
Sbjct: 30 FAKLESFNP-GGSHKARIALWMILDAERKGILVRGKGQTIL-EPSGGNTGIGLAMAGNIL 87
Query: 60 GLKFRAYIPKPTPKTTELLIKVFGAEVVRTNFDTIDKKFVEF-VKLEARRDKALNLNQFE 118
G + +P L++++GA VV ++ + E +++ + + LNQ
Sbjct: 88 GYRVSLVVPDNYSPDKRQLLELYGAHVVLSDSRKGNNSHGELAIQILLEHPEFVMLNQQR 147
Query: 119 NDANFEAHYYGTARELEEQLRSIDKIPEIIIAGIGTSGHIAGISKYFKERY-ETKIIGVV 177
N AN +AH TA E+ P+ AGIGT GHI G+ + + + + I GV
Sbjct: 148 NPANPQAHREATALEILRDFAG-QPPPDFFFAGIGTGGHITGVGEVLRNHWPDMAIYGVQ 206
Query: 178 PAK---------GETIPGIKRLETRPKWFFKVEVDEVVEVTAREAFEGILKVARSDGLLI 228
P + I G+ + P+ V +V V+ I +V ++D + +
Sbjct: 207 PEQCDLLDDRHASHEIQGLS-IGIVPEVCNLGIVTGMVGVSKSACLSMIREVLQNDSVSM 265
Query: 229 GMSSGA---VVKAYEKVRPEGTTVLIFPDDG 256
G+SS A V P G VL DG
Sbjct: 266 GLSSAANLVAVLNMASAMPSGARVLTMIYDG 296
>emb|CAB55622.1| (AJ011044) cysteine synthase [Arabidopsis thaliana]
Length = 176
Score = 75.7 bits (183), Expect = 6e-13
Identities = 59/173 (34%), Positives = 91/173 (52%), Gaps = 20/173 (11%)
Query: 116 QFENDANFEAHYYGTARELEEQLRSIDKIPEIIIAGIGTSGHIAGISKYFKERY-ETKII 174
QFEN AN E HY T E+ S K+ +I++AG+GT G G+ K+ KE+ + K+
Sbjct: 2 QFENPANPEIHYRTTGPEIWRD--SAGKV-DILVAGVGTGGTATGVGKFLKEQNKDIKVC 58
Query: 175 GVVPAKGETI----PGIKRLETRPKWF--FKVE---VDEVVEVTAREAFEGILKVARSDG 225
V P + + PG ++ F ++ VDE+++V EA E +A +G
Sbjct: 59 VVEPVESPVLSGGQPGPHLIQGIGSGIVPFNLDLTIVDEIIQVAGEEAIETAKLLALKEG 118
Query: 226 LLIGMSSGAVVKAYEKV--RPEGT---TVLIFPDDGFKY--GEIFEMLLGEAQ 271
LL+G+SSGA A KV RPE V++FP G +Y ++F+ + EA+
Sbjct: 119 LLVGISSGAAAAAALKVAKRPENAGKLIVVVFPSGGERYLSTKLFDSIRYEAE 171
>pir||E83595 cystathionine beta-synthase PA0399 [imported] - Pseudomonas
aeruginosa (strain PAO1)
>gi|9946253|gb|AAG03788.1|AE004477_5 (AE004477)
cystathionine beta-synthase [Pseudomonas aeruginosa]
Length = 457
Score = 70.2 bits (169), Expect = 3e-11
Identities = 69/258 (26%), Positives = 111/258 (42%), Gaps = 28/258 (10%)
Query: 3 FAKLEFFNPFSRSIKDRAVYNMLIKALRSGEIDGTNVLYEATSGNVGISIAALSAVFGLK 62
+ KLE NP SIKDR M+ A R G + + EAT+GN G+ +A + G +
Sbjct: 32 YLKLESQNP-GGSIKDRIGVAMIEAAERDGRLRPGGTIVEATAGNTGLGLALVGRAKGYR 90
Query: 63 FRAYIPKPTPKTTELLIKVFGAEVVRTNFDTIDKKFVEFVKLEARR-----DKALNLNQF 117
+P L ++ GAEV T D + K E+ + A R A +QF
Sbjct: 91 VVLVVPDKMSTEKVLHLRAMGAEVHITRSD-VGKGHPEYYQDVAARLAQDIPGAFFADQF 149
Query: 118 ENDANFEAHYYGTARELEEQL-RSIDKIPEIIIAGIGTSGHIAGISKYFKERYETKIIGV 176
N AN AH GT EL Q +D I+ G+G+SG + G++++F++ + +
Sbjct: 150 NNPANPLAHECGTGPELWAQTGHDLD----AIVVGVGSSGTLTGLTRFFQKVQPELEMVL 205
Query: 177 VPAKGETIPGIKR---LETRPKWFFK-------------VEVDEVVEVTAREAFEGILKV 220
+G + R L T W + V ++ E+F ++
Sbjct: 206 ADPEGSIMAEYSRSGTLGTPGSWAVEGIGEDFVPAIADLSSVRHAYSISDEESFAMAREL 265
Query: 221 ARSDGLLIGMSSGAVVKA 238
R +G+ G S+G ++ A
Sbjct: 266 LRVEGIPGGSSTGTLLAA 283
Database: ./suso.pep
Posted date: Jul 6, 2001 5:57 PM
Number of letters in database: 840,471
Number of sequences in database: 2977
Database: /banques/blast2/nr.pep
Posted date: Dec 14, 2000 12:46 PM
Number of letters in database: 188,266,275
Number of sequences in database: 595,510
Lambda K H
0.319 0.138 0.383
Gapped
Lambda K H
0.270 0.0470 0.230
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 98144365
Number of Sequences: 2977
Number of extensions: 3983330
Number of successful extensions: 11570
Number of sequences better than 1.0e-10: 137
Number of HSP's better than 0.0 without gapping: 2
Number of HSP's successfully gapped in prelim test: 135
Number of HSP's that attempted gapping in prelim test: 11187
Number of HSP's gapped (non-prelim): 143
length of query: 284
length of database: 189,106,746
effective HSP length: 58
effective length of query: 226
effective length of database: 154,394,500
effective search space: 34893157000
effective search space used: 34893157000
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 41 (21.7 bits)
S2: 164 (68.3 bits)