BLASTP 2.0.10 [Aug-26-1999]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= PAB0286 (leuA-2) DE:2-isopropylmalate synthase (leuA-2)
(361 letters)
Database: ./suso.pep; /banques/blast2/nr.pep
598,487 sequences; 189,106,746 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
pir||G75159 2-isopropylmalate synthase (leua-2) PAB0286 - Pyroco... 725 0.0
pir||B71181 probable 2-isopropylmalate synthase - Pyrococcus hor... 630 e-180
gb|AAK41252.1| 2-isopropylmalate synthase (leuA-2) [Sulfolobus s... 321 6e-87
gi|11497835 2-isopropylmalate synthase (leuA-2) [Archaeoglobus f... 258 8e-68
sp|Q58787|YD92_METJA PUTATIVE 2-ISOPROPYLMALATE/HOMOCITRATE SYNT... 254 1e-66
pir||H69084 2-isopropylmalate synthase - Methanobacterium thermo... 254 2e-66
gi|11498562 2-isopropylmalate synthase (leuA-1) [Archaeoglobus f... 253 2e-66
pir||F69196 2-isopropylmalate synthase - Methanobacterium thermo... 251 8e-66
sp|Q58595|YB95_METJA PUTATIVE 2-ISOPROPYLMALATE/HOMOCITRATE SYNT... 247 2e-64
pir||D69064 isopropylmalate synthase - Methanobacterium thermoau... 247 2e-64
sp|Q57926|Y503_METJA PUTATIVE 2-ISOPROPYLMALATE/HOMOCITRATE SYNT... 244 1e-63
gb|AAK42554.1| 2-isopropylmalate synthase, putative (leuA-3) [S... 231 7e-60
sp|Q9WZ23|LEU1_THEMA 2-ISOPROPYLMALATE SYNTHASE (ALPHA-ISOPROPYL... 209 4e-53
sp|Q12726|HOSM_YARLI HOMOCITRATE SYNTHASE, MITOCHONDRIAL PRECURS... 206 4e-52
emb|CAB91069.1| (AJ239033) homocitrate sythase 1 [Anabaena varia... 203 4e-51
pir||T39279 probable homocitrate synthase (EC 4.1.3.21), mitocho... 202 6e-51
pir||F75391 2-isopropylmalate synthase - Deinococcus radiodurans... 201 8e-51
gi|6320019 homocitrate synthase, highly homologous to YDL131W; L... 201 1e-50
gi|6320071 homocitrate synthase, highly homologous to YDL182W; L... 201 1e-50
pir||A75045 2-isopropylmalate synthase (leua-1) PAB0890 - Pyroco... 200 2e-50
sp|O87198|HOSC_THETH HOMOCITRATE SYNTHASE >gi|11268243|pir||T511... 199 3e-50
pir||D75418 homocitrate synthase - Deinococcus radiodurans (stra... 199 4e-50
gb|AAF13763.1|AF117351_20 (AF117351) homocitrate synthase [Zymom... 199 5e-50
emb|CAB91068.1| (AJ239032) homocitrate synthase 2 [Anabaena vari... 197 2e-49
gb|AAK40481.1| 2-isopropylmalate synthase, putative (leuA-1) [S... 196 3e-49
gi|10954450 isopropylmalate synthase [Buchnera aphidicola] >gi|3... 191 9e-48
pir||C83494 probable 2-isopropylmalate synthase PA1217 [imported... 191 9e-48
sp|O94225|HOSM_PENCH HOMOCITRATE SYNTHASE, MITOCHONDRIAL PRECURS... 190 2e-47
gi|10954458 2-isopropylmalate synthase [Buchnera aphidicola] >gi... 188 1e-46
sp|P48571|LEU1_BUCRP 2-ISOPROPYLMALATE SYNTHASE (ALPHA-ISOPROPYL... 187 2e-46
sp|O67862|LEU1_AQUAE 2-ISOPROPYLMALATE SYNTHASE (ALPHA-ISOPROPYL... 185 7e-46
sp|Q02141|LEU1_LACLA 2-ISOPROPYLMALATE SYNTHASE (ALPHA-ISOPROPYL... 181 1e-44
gb|AAB81913.1| (U92974) LeuA [Lactococcus lactis] 181 1e-44
emb|CAA07305.2| (AJ006878) 2-isoproylmalate synthase [Buchnera a... 180 2e-44
gi|10957107 2-isopropylmalate synthase [Buchnera sp. APS] >gi|11... 180 3e-44
pir||F82070 2-isopropylmalate synthase VC2490 [imported] - Vibri... 179 5e-44
pir||E75045 2-isopropylmalate synthase (leua-3) PAB0894 - Pyroco... 178 9e-44
pir||C81270 2-isopropylmalate synthase (EC 4.1.3.12) Cj1719c [im... 175 6e-43
dbj|BAB06777.1| (AP001517) 2-isopropylmalate synthase [Bacillus ... 175 6e-43
pir||E64106 2-isopropylmalate synthase (EC 4.1.3.12) - Haemophil... 173 2e-42
sp|P43861|LEU1_HAEIN 2-ISOPROPYLMALATE SYNTHASE (ALPHA-ISOPROPYL... 173 2e-42
sp|P94565|LEU1_BACSU 2-ISOPROPYLMALATE SYNTHASE (ALPHA-ISOPROPYL... 172 6e-42
gb|AAG27075.1|AF105225_11 (AF105225) NifV [Acetobacter diazotrop... 171 9e-42
gb|AAG31377.1| (AF197448) 2-isopropylmaltate synthase [Buchnera ... 171 1e-41
gb|AAG31398.1| (AF197455) 2-isopropylmaltate synthase [Buchnera ... 171 1e-41
gb|AAG31383.1| (AF197450) 2-isopropylmaltate synthase [Buchnera ... 170 2e-41
pir||S40588 hypothetical protein - Escherichia coli >gi|216492|d... 170 3e-41
pir||G81125 2-isopropylmalate synthase NMB1070 [imported] - Neis... 170 3e-41
gb|AAG31401.1| (AF197456) 2-isopropylmaltate synthase [Buchnera ... 170 3e-41
gb|AAG31404.1| (AF197457) 2-isopropylmaltate synthase [Buchnera ... 170 3e-41
pir||C81895 probable 2-isopropylmalate synthase (EC 4.1.3.12) NM... 169 3e-41
sp|P94907|LEU1_MICAE 2-ISOPROPYLMALATE SYNTHASE (ALPHA-ISOPROPYL... 169 4e-41
sp|P09151|LEU1_ECOLI 2-ISOPROPYLMALATE SYNTHASE (ALPHA-ISOPROPYL... 169 4e-41
sp|P48576|LEU1_SYNY3 2-ISOPROPYLMALATE SYNTHASE (ALPHA-ISOPROPYL... 169 6e-41
sp|Q52070|NIFV_ENTAG HOMOCITRATE SYNTHASE >gi|1480128|emb|CAA680... 167 2e-40
dbj|BAB09819.1| (AB006708) 2-isopropylmalate synthase-like prote... 167 2e-40
sp|P05342|NIFV_AZOVI HOMOCITRATE SYNTHASE >gi|420863|pir||S29758... 166 5e-40
sp|Q9WZ22|LY41_THEMA PUTATIVE LYASE TM0552 >gi|7447065|pir||F723... 166 5e-40
gb|AAG31927.1|AF200469_1 (AF200469) 2-isopropylmalate synthase [... 166 5e-40
gb|AAF36732.1| (AC016662) putative 2-isopropylmalate synthase; 3... 165 6e-40
gb|AAG31395.1| (AF197454) 2-isopropylmaltate synthase [Buchnera ... 164 1e-39
gb|AAG31389.1| (AF197452) 2-isopropylmaltate synthase [Buchnera ... 163 2e-39
sp|Q07179|NIFV_RHOCA HOMOCITRATE SYNTHASE >gi|486695|pir||S34817... 163 3e-39
pir||S02508 homocitrate synthase (EC 4.1.3.21) - Klebsiella pneu... 163 3e-39
gb|AAA22169.1| (M17349) nifV protein [Azotobacter vinelandii] 163 3e-39
gb|AAG31392.1| (AF197453) 2-isopropylmaltate synthase [Buchnera ... 162 6e-39
sp|Q39891|LEU1_SOYBN PROBABLE 2-ISOPROPYLMALATE SYNTHASE (ALPHA-... 162 7e-39
gb|AAG31926.1|AF200468_1 (AF200468) 2-isopropylmalate synthase [... 161 1e-38
gb|AAG31386.1| (AF197451) 2-isopropylmaltate synthase [Buchnera ... 161 1e-38
dbj|BAB08874.1| (AB026660) 2-isopropylmalate synthase-like; homo... 161 2e-38
pir||A82634 2-isopropylmalate synthase XF1818 [imported] - Xylel... 160 3e-38
sp|O04973|LU1A_LYCPN 2-ISOPROPYLMALATE SYNTHASE A (ALPHA-ISOPROP... 159 4e-38
sp|P48575|LEU1_ANASP 2-ISOPROPYLMALATE SYNTHASE (ALPHA-ISOPROPYL... 159 5e-38
gb|AAF26002.1|AC013354_21 (AC013354) F15H18.3 [Arabidopsis thali... 159 5e-38
sp|P05345|NIFV_KLEPN HOMOCITRATE SYNTHASE >gi|479601|pir||S34848... 159 6e-38
sp|Q01181|NIFV_RHOSH HOMOCITRATE SYNTHASE >gi|282178|pir||D41880... 159 6e-38
pir||S37297 nifV protein - Klebsiella pneumoniae >gi|149345|gb|A... 158 8e-38
sp|O66682|LY41_AQUAE PUTATIVE LYASE AQ_356 >gi|7447064|pir||F703... 158 8e-38
sp|Q47884|NIFV_FRAAL HOMOCITRATE SYNTHASE >gi|1256029|gb|AAA9626... 157 1e-37
sp|P74269|LY41_SYNY3 PUTATIVE LYASE SLL1564 >gi|7447061|pir||S75... 156 4e-37
sp|O86511|LY41_STRCO PUTATIVE LYASE SC1C2.10 >gi|7480336|pir||T2... 155 7e-37
sp|Q44290|NIFV_ANASP HOMOCITRATE SYNTHASE >gi|1487879|emb|CAA681... 154 1e-36
sp|O04974|LU1B_LYCPN 2-ISOPROPYLMALATE SYNTHASE B (ALPHA-ISOPROP... 153 3e-36
sp|P23122|NIFV_AZOCH HOMOCITRATE SYNTHASE >gi|280010|pir||C43706... 152 6e-36
gb|AAG31380.1| (AF197449) 2-isopropylmaltate synthase [Buchnera ... 151 1e-35
sp|P54610|NIFV_FRASP HOMOCITRATE SYNTHASE >gi|1280032|gb|AAB3687... 150 2e-35
sp|P15875|LEU1_SALTY 2-ISOPROPYLMALATE SYNTHASE (ALPHA-ISOPROPYL... 146 5e-34
gb|AAF66618.1|AF142777_1 (AF142777) homocitrate synthase [Neuros... 137 2e-31
sp|Q00853|NIVA_CLOPA HOMOCITRATE SYNTHASE, ALPHA SUBUNIT >gi|986... 135 9e-31
sp|P70728|NIFV_AZOBR HOMOCITRATE SYNTHASE >gi|1597740|gb|AAC4617... 127 2e-28
sp|Q56216|LEU1_THETH 2-ISOPROPYLMALATE SYNTHASE (ALPHA-ISOPROPYL... 115 7e-25
emb|CAA91564.1| (Z67750) putative protein [Saccharomyces cerevis... 115 9e-25
emb|CAA72697.1| (Y11966) 2-isopropylmalate synthase [Buchnera ap... 115 9e-25
emb|CAB60077.1| (Y18874) 2-isopropylmalate synthase [Synechococc... 92 7e-18
pir||B70567 probable mhpE protein - Mycobacterium tuberculosis (... 79 9e-14
dbj|BAA90528.1| (AB029822) 2-phosphinomethylmalic acid synthase ... 77 3e-13
>pir||G75159 2-isopropylmalate synthase (leua-2) PAB0286 - Pyrococcus abyssi
(strain Orsay) >gi|5457868|emb|CAB49358.1| (AJ248284)
2-isopropylmalate synthase (leuA-2) [Pyrococcus abyssi]
Length = 361
Score = 725 bits (1852), Expect = 0.0
Identities = 361/361 (100%), Positives = 361/361 (100%)
Query: 1 MVLDSTLREGEQTPGVNYTPEQRLEIAIALDEVGVDFIEIGHPAVSEDVFRGMKLIAEQG 60
MVLDSTLREGEQTPGVNYTPEQRLEIAIALDEVGVDFIEIGHPAVSEDVFRGMKLIAEQG
Sbjct: 1 MVLDSTLREGEQTPGVNYTPEQRLEIAIALDEVGVDFIEIGHPAVSEDVFRGMKLIAEQG 60
Query: 61 LNVELLAHSRALIEDIDYVLKTGVDWVGIFFCLSEACLRKRFRITLDHALEKISRAIEYA 120
LNVELLAHSRALIEDIDYVLKTGVDWVGIFFCLSEACLRKRFRITLDHALEKISRAIEYA
Sbjct: 61 LNVELLAHSRALIEDIDYVLKTGVDWVGIFFCLSEACLRKRFRITLDHALEKISRAIEYA 120
Query: 121 KDHGLKVRFTPEDTTRTEWANLKRAIRLAKELKVDRISVADTTGSTHPLRFYTLVKKIVN 180
KDHGLKVRFTPEDTTRTEWANLKRAIRLAKELKVDRISVADTTGSTHPLRFYTLVKKIVN
Sbjct: 121 KDHGLKVRFTPEDTTRTEWANLKRAIRLAKELKVDRISVADTTGSTHPLRFYTLVKKIVN 180
Query: 181 FGIPVNVHCHNDLGLALANAIMGIEAGATLVDATVNGLGERAGIVDLAQIITVLYYHYGI 240
FGIPVNVHCHNDLGLALANAIMGIEAGATLVDATVNGLGERAGIVDLAQIITVLYYHYGI
Sbjct: 181 FGIPVNVHCHNDLGLALANAIMGIEAGATLVDATVNGLGERAGIVDLAQIITVLYYHYGI 240
Query: 241 KKYRLDLLYRVSNLVSEITGISPQPNYPIVGENAFTHKAGLHVSAVLKDPRFYEFLPAEV 300
KKYRLDLLYRVSNLVSEITGISPQPNYPIVGENAFTHKAGLHVSAVLKDPRFYEFLPAEV
Sbjct: 241 KKYRLDLLYRVSNLVSEITGISPQPNYPIVGENAFTHKAGLHVSAVLKDPRFYEFLPAEV 300
Query: 301 FGRERTIYVDRYAGKDTIRYYLEKFGIRDHGIVTSLLRKVKSSREPFTWEKLLEEARRVK 360
FGRERTIYVDRYAGKDTIRYYLEKFGIRDHGIVTSLLRKVKSSREPFTWEKLLEEARRVK
Sbjct: 301 FGRERTIYVDRYAGKDTIRYYLEKFGIRDHGIVTSLLRKVKSSREPFTWEKLLEEARRVK 360
Query: 361 E 361
E
Sbjct: 361 E 361
>pir||B71181 probable 2-isopropylmalate synthase - Pyrococcus horikoshii
>gi|3258158|dbj|BAA30841.1| (AP000007) 361aa long
hypothetical 2-isopropylmalate synthase [Pyrococcus
horikoshii]
Length = 361
Score = 630 bits (1608), Expect = e-180
Identities = 302/360 (83%), Positives = 332/360 (91%)
Query: 1 MVLDSTLREGEQTPGVNYTPEQRLEIAIALDEVGVDFIEIGHPAVSEDVFRGMKLIAEQG 60
M+LDSTLREGEQTPGVNY+PEQRL IA+ALDE+GVDFIE+GHPAVS+DVF G+KLIA Q
Sbjct: 1 MILDSTLREGEQTPGVNYSPEQRLRIALALDEIGVDFIEVGHPAVSKDVFIGIKLIASQD 60
Query: 61 LNVELLAHSRALIEDIDYVLKTGVDWVGIFFCLSEACLRKRFRITLDHALEKISRAIEYA 120
LN LLAHSRAL+EDIDYV++ V+WVGIFFCLS ACLRKRFR++L ALE+IS+AIEYA
Sbjct: 61 LNANLLAHSRALLEDIDYVIQADVEWVGIFFCLSNACLRKRFRMSLSQALERISKAIEYA 120
Query: 121 KDHGLKVRFTPEDTTRTEWANLKRAIRLAKELKVDRISVADTTGSTHPLRFYTLVKKIVN 180
KDHGLKVRFTPEDTTRTEW NL+RAI LAKELKVDRISVADTTG THPLRFYTLVKK+VN
Sbjct: 121 KDHGLKVRFTPEDTTRTEWENLRRAIELAKELKVDRISVADTTGGTHPLRFYTLVKKVVN 180
Query: 181 FGIPVNVHCHNDLGLALANAIMGIEAGATLVDATVNGLGERAGIVDLAQIITVLYYHYGI 240
FGIPVNVHCHNDLGLALANAIMGIE GAT+VDATVNGLGERAGIVDLAQI+TVLYYHYG+
Sbjct: 181 FGIPVNVHCHNDLGLALANAIMGIEGGATVVDATVNGLGERAGIVDLAQIVTVLYYHYGV 240
Query: 241 KKYRLDLLYRVSNLVSEITGISPQPNYPIVGENAFTHKAGLHVSAVLKDPRFYEFLPAEV 300
KKYRLD LY +S +VSEITGI+ QPNYPIVGENAFTHKAGLHVSAVLKDPRFYEFLPAEV
Sbjct: 241 KKYRLDKLYEISRMVSEITGIALQPNYPIVGENAFTHKAGLHVSAVLKDPRFYEFLPAEV 300
Query: 301 FGRERTIYVDRYAGKDTIRYYLEKFGIRDHGIVTSLLRKVKSSREPFTWEKLLEEARRVK 360
FGRERTIYVDR+AGKDTIRYYL+K GI D V LL++VKSSREPFTW+K +EE RR+K
Sbjct: 301 FGRERTIYVDRFAGKDTIRYYLQKLGINDEEFVKVLLKRVKSSREPFTWDKFIEEVRRLK 360
>gb|AAK41252.1| 2-isopropylmalate synthase (leuA-2) [Sulfolobus solfataricus]
Length = 461
Score = 321 bits (815), Expect = 6e-87
Identities = 165/351 (47%), Positives = 233/351 (66%), Gaps = 11/351 (3%)
Query: 2 VLDSTLREGEQTPGVNYTPEQRLEIAIALDEVGVDFIEIGHPAVSEDVFRGMKLIA---- 57
+LDSTLREGEQTPGV +T +QR+EIA AL ++GV IE GHPAVS D++ G+K I
Sbjct: 6 ILDSTLREGEQTPGVIFTVDQRVEIAKALSDLGVSMIEAGHPAVSPDIYEGIKRIVKLKK 65
Query: 58 EQGLNVELLAHSRALIEDIDYVLKTGVDWVGIFFCLSEACLRKRFRITLDHALEKISRAI 117
E + E++ HSRA+ DI+ + VD + IF+ +S+ L+ + + T + AL I+ I
Sbjct: 66 EGIITSEIVGHSRAVKRDIEIAAELEVDRIAIFYGVSDIHLKAKHKATREEALRVIAETI 125
Query: 118 EYAKDHGLKVRFTPEDTTRTEWANLKRAIRLAKELKVDRISVADTTGSTHPLR----FYT 173
YA+ HG+KVRFT ED +RT++ L R A++ DR+S+ADT G +P + F
Sbjct: 126 SYARSHGVKVRFTAEDGSRTDFDFLVTVSRTARDAGADRVSIADTVGILYPSKTKELFSA 185
Query: 174 LVKKIVNFGIPVNVHCHNDLGLALANAIMGIEAGATLVDATVNGLGERAGIVDLAQIITV 233
L++++ N + ++H HNDLGLA+ANA+ +E GAT+V ATVNGLGER GIV L QI+
Sbjct: 186 LIREVPN--LEYDIHAHNDLGLAVANALAAVEGGATIVHATVNGLGERVGIVPLQQIVAA 243
Query: 234 LYYHYGIKKYRLDLLYRVSNLVSEITGISPQPNYPIVGENAFTHKAGLHVSAVLKDPRFY 293
+ YH+GI+ +LD L VS+L+ + +GI PNYPI G+ AF HKAG+HV+ VL DPR Y
Sbjct: 244 IKYHFGIEVVKLDKLQYVSSLIEKYSGIPMPPNYPITGDYAFLHKAGVHVAGVLSDPRTY 303
Query: 294 EFLPAEVFGRERTIYVDRYAGKDTIRYYLEKFGIR-DHGIVTSLLRKVKSS 343
EF+P E FGR R +D+Y GK +R EK G++ + +L K+KS+
Sbjct: 304 EFMPPETFGRTRDYTIDKYTGKHALRDKYEKLGVKISEAEMDQILAKIKSN 354
>gi|11497835 2-isopropylmalate synthase (leuA-2) [Archaeoglobus fulgidus]
>gi|7447060|pir||C69277 2-isopropylmalate synthase
(leuA-2) homolog - Archaeoglobus fulgidus
>gi|2650424|gb|AAB91014.1| (AE001091) 2-isopropylmalate
synthase (leuA-2) [Archaeoglobus fulgidus]
Length = 503
Score = 258 bits (652), Expect = 8e-68
Identities = 138/345 (40%), Positives = 206/345 (59%), Gaps = 5/345 (1%)
Query: 2 VLDSTLREGEQTPGVNYTPEQRLEIAIALDEVGVDFIEIGHPAVSEDVFRGMKLIAEQGL 61
V D+TLR+GEQ PGV+ E ++ IA LD++GVD IE G P+ ++ F +K I+ L
Sbjct: 10 VFDTTLRDGEQMPGVSLPLEYKIRIAKQLDKLGVDVIEAGFPSATKGEFESVKEISSLSL 69
Query: 62 NVELLAHSRALIEDIDYVLKTGVDWVGIFFCLSEACLRKRFRITLDHALEKISRAIEYAK 121
N E+ +R + EDID + VD V IF S + +++ + +EK +EY K
Sbjct: 70 NAEICGLARIVKEDIDAAINANVDMVHIFVPTSRIQIEHTVKMSKEEIIEKSVECVEYIK 129
Query: 122 DHGLKVRFTPEDTTRTEWANLKRAIRLAKELKVDRISVADTTGSTHPLRFYTLVKKI-VN 180
HG+K F+ D TRTE LK+ + + KVD ++V DT G P +FY L+K++ +
Sbjct: 130 SHGVKCMFSAMDATRTEVEYLKQIFKAVENAKVDIVNVPDTVGVATPFKFYELIKQLREH 189
Query: 181 FGIPVNVHCHNDLGLALANAIMGIEAGATLVDATVNGLGERAGIVDLAQIITVLYYHYGI 240
+P++VHCHND GLA+AN + AGA V TVNG+GERAG DLAQ++ +L+ GI
Sbjct: 190 LKVPIDVHCHNDFGLAVANTYAAVMAGANEVQVTVNGIGERAGNADLAQVVMILHAIEGI 249
Query: 241 K-KYRLDLLYRVSNLVSEITGISPQPNYPIVGENAFTHKAGLHVSAVLKDPRFYE--FLP 297
K + + L+ S LV +TG+ PN+PIVGENAF+H++G+H VLK+ +E +
Sbjct: 250 KTNIKTEHLFETSKLVERLTGVKMPPNHPIVGENAFSHESGIHAHGVLKEYSTFEPGVVT 309
Query: 298 AEVFGRERTIYVDRYAGKDTIRYYLEKFGIR-DHGIVTSLLRKVK 341
E+ G +R I + ++AG+ I+ LE+ G D + + KVK
Sbjct: 310 PEMVGHKRRIVIGKHAGRYQIKKILEEAGYHLDDEKLNQIFEKVK 354
>sp|Q58787|YD92_METJA PUTATIVE 2-ISOPROPYLMALATE/HOMOCITRATE SYNTHASE MJ1392
>gi|2127716|pir||G64473 2-isopropylmalate synthase (EC
4.1.3.12) - Methanococcus jannaschii
>gi|1592039|gb|AAB99402.1| (U67579) 2-isopropylmalate
synthase (leuA) [Methanococcus jannaschii]
Length = 491
Score = 254 bits (642), Expect = 1e-66
Identities = 136/328 (41%), Positives = 195/328 (58%), Gaps = 2/328 (0%)
Query: 2 VLDSTLREGEQTPGVNYTPEQRLEIAIALDEVGVDFIEIGHPAVSEDVFRGMKLIAEQGL 61
+ D+TLR+GEQTPGV+ TP +LEIA LDE+GVD IE G S+ G+KLI ++GL
Sbjct: 5 IFDTTLRDGEQTPGVSLTPNDKLEIAKKLDELGVDVIEAGSAITSKGEREGIKLITKEGL 64
Query: 62 NVELLAHSRALIEDIDYVLKTGVDWVGIFFCLSEACLRKRFRITLDHALEKISRAIEYAK 121
N E+ + RAL DID L+ VD V + S ++ + R T D LE +A+EYAK
Sbjct: 65 NAEICSFVRALPVDIDAALECDVDSVHLVVPTSPIHMKYKLRKTEDEVLETALKAVEYAK 124
Query: 122 DHGLKVRFTPEDTTRTEWANLKRAIRLAKELKVDRISVADTTGSTHPLRFYTLVKKIV-N 180
+HGL V + ED TR++ L + +++ DR+ V DT G P + L KKI N
Sbjct: 125 EHGLIVELSAEDATRSDVNFLIKLFNEGEKVGADRVCVCDTVGVLTPQKSQELFKKITEN 184
Query: 181 FGIPVNVHCHNDLGLALANAIMGIEAGATLVDATVNGLGERAGIVDLAQIITVLYYHYGI 240
+PV+VHCHND G+A AN + GA TVNG+GERAG L +++ L YG
Sbjct: 185 VNLPVSVHCHNDFGMATANTCSAVLGGAVQCHVTVNGIGERAGNASLEEVVAALKILYGY 244
Query: 241 -KKYRLDLLYRVSNLVSEITGISPQPNYPIVGENAFTHKAGLHVSAVLKDPRFYEFLPAE 299
K +++ LY VS +VS + + PN IVG+NAF H+AG+HV ++K+ YE + E
Sbjct: 245 DTKIKMEKLYEVSRIVSRLMKLPVPPNKAIVGDNAFAHEAGIHVDGLIKNTETYEPIKPE 304
Query: 300 VFGRERTIYVDRYAGKDTIRYYLEKFGI 327
+ G R I + +++G+ ++Y L+ GI
Sbjct: 305 MVGNRRRIILGKHSGRKALKYKLDLMGI 332
>pir||H69084 2-isopropylmalate synthase - Methanobacterium thermoautotrophicum
(strain Delta H) >gi|2622757|gb|AAB86103.1| (AE000922)
2-isopropylmalate synthase [Methanobacterium
thermoautotrophicum]
Length = 391
Score = 254 bits (641), Expect = 2e-66
Identities = 145/350 (41%), Positives = 214/350 (60%), Gaps = 9/350 (2%)
Query: 2 VLDSTLREGEQTPGVNYTPEQRLEIAIALDEVGVDFIEIGHPAVSEDVFRGMKLIAEQGL 61
+ D+TLR+GEQTPGV E++LEIA LDE+G+ IE G P VSE +K IA +GL
Sbjct: 22 IYDTTLRDGEQTPGVCLGTEEKLEIARKLDELGIHQIESGFPVVSEQERVSVKSIANEGL 81
Query: 62 NVELLAHSRALIEDIDYVLKTGVDWVGIFFCLSEACLRKRFRITLDHALEKISRAIEYAK 121
N E+LA R +DID + VD V F S+ L+ + ++T + AL +IEYAK
Sbjct: 82 NAEILALCRTKKDDIDAAIDCDVDGVITFMATSDLHLKHKLKLTREEALNVCMNSIEYAK 141
Query: 122 DHGLKVRFTPEDTTRTEWANLKRAIRLAKELKVDRISVADTTGSTHPLRFYTLVKKI-VN 180
DHGL + F+ ED TRT+ LK+ R A+ DR+ +ADT G+ P LV+++ +
Sbjct: 142 DHGLFLAFSAEDATRTDLDFLKQIYRKAENYGADRVHIADTVGAISPQGMDYLVRELRRD 201
Query: 181 FGIPVNVHCHNDLGLALANAIMGIEAGATLVDATVNGLGERAGIVDLAQIITVLYYHYGI 240
+ + +HCHND G+AL+N+I G+ AG T V TVNG+GERAG L ++I L Y +
Sbjct: 202 IKVDIALHCHNDFGMALSNSIAGLLAGGTAVSTTVNGIGERAGNTSLEELIMALRIIYEV 261
Query: 241 K-KYRLDLLYRVSNLVSEITGISPQPNYPIVGENAFTHKAGLHVSAVLKDPRFYE-FLPA 298
+ + +LY +S LV + T + N PIVG N F H++G+HV AV+++P YE FLP
Sbjct: 262 DLGFNIGVLYELSRLVEKHTRMKVPENKPIVGRNVFRHESGIHVDAVIEEPLTYEPFLP- 320
Query: 299 EVFGRERTIYVDRYAGKDTIRYYLEKFGI---RDHGIVTSLLRKVKSSRE 345
E+ G +R I + +++G ++ LE++GI RD + ++ +VK +RE
Sbjct: 321 EMIGHQRKIVLGKHSGCRAVKAKLEEYGIDVTRDE--LCRIVEEVKKNRE 368
>gi|11498562 2-isopropylmalate synthase (leuA-1) [Archaeoglobus fulgidus]
>gi|7447057|pir||E69369 2-isopropylmalate synthase
(leuA-1) homolog - Archaeoglobus fulgidus
>gi|2649641|gb|AAB90286.1| (AE001038) 2-isopropylmalate
synthase (leuA-1) [Archaeoglobus fulgidus]
Length = 489
Score = 253 bits (640), Expect = 2e-66
Identities = 136/330 (41%), Positives = 205/330 (61%), Gaps = 3/330 (0%)
Query: 2 VLDSTLREGEQTPGVNYTPEQRLEIAIALDEVGVDFIEIGHPAVSEDVFRGMKLIAEQGL 61
+LD+TLR+GEQTPGV+ + EQ++ IA ALD +GVD IE G SE F+ +K I+++GL
Sbjct: 5 ILDTTLRDGEQTPGVSLSVEQKVMIAEALDNLGVDIIEAGTAIASEGDFQAIKEISQRGL 64
Query: 62 NVELLAHSRALIEDIDYVLKTGVDWVGIFFCLSEACLRKRF-RITLDHALEKISRAIEYA 120
N E+ + +R EDID G + + + S+ + +F D+ +EK AIEYA
Sbjct: 65 NAEICSFARIKREDIDAAADAGAESIFMVAPSSDIHINAKFPGKDRDYVIEKSVEAIEYA 124
Query: 121 KDHGLKVRFTPEDTTRTEWANLKRAIRLAKELKVDRISVADTTGSTHPLRFYTLVKKI-V 179
K+ GL V F ED +R + + + + A+E K DRI+ ADT G P + +V+KI
Sbjct: 125 KERGLIVEFGAEDASRADLDFVIQLFKRAEEAKADRITFADTVGVLSPEKMEEIVRKIKA 184
Query: 180 NFGIPVNVHCHNDLGLALANAIMGIEAGATLVDATVNGLGERAGIVDLAQIITVLYYHYG 239
+P+ +HCH+D GLA AN I GI+AGA T+NGLGERAG + +++ L Y YG
Sbjct: 185 KVKLPLAIHCHDDFGLATANTIFGIKAGAEEFHGTINGLGERAGNAAIEEVVIALEYLYG 244
Query: 240 IK-KYRLDLLYRVSNLVSEITGISPQPNYPIVGENAFTHKAGLHVSAVLKDPRFYEFLPA 298
IK K + + LY S LV +++ + PN PIVG+NAFTH++G+H SA+ +D + YE +
Sbjct: 245 IKTKIKKERLYNTSKLVEKLSRVVVPPNKPIVGDNAFTHESGIHTSALFRDAKSYEPISP 304
Query: 299 EVFGRERTIYVDRYAGKDTIRYYLEKFGIR 328
EV GR+R I + ++AG+ ++ + + G +
Sbjct: 305 EVVGRKRVIVLGKHAGRASVEAIMNELGYK 334
>pir||F69196 2-isopropylmalate synthase - Methanobacterium thermoautotrophicum
(strain Delta H) >gi|2621811|gb|AAB85228.1| (AE000851)
2-isopropylmalate synthase [Methanobacterium
thermoautotrophicum]
Length = 496
Score = 251 bits (635), Expect = 8e-66
Identities = 130/328 (39%), Positives = 193/328 (58%), Gaps = 1/328 (0%)
Query: 2 VLDSTLREGEQTPGVNYTPEQRLEIAIALDEVGVDFIEIGHPAVSEDVFRGMKLIAEQGL 61
VLD+TLR+GEQTPGV+ TPE++L IA+ +D +G D IE G SE G++ I +GL
Sbjct: 5 VLDTTLRDGEQTPGVSLTPEEKLRIALKIDALGADIIEAGSAITSEGEREGIRKITSEGL 64
Query: 62 NVELLAHSRALIEDIDYVLKTGVDWVGIFFCLSEACLRKRFRITLDHALEKISRAIEYAK 121
E+ + +RA+ EDID + VD V + S+ L + R T + LE+ EYA
Sbjct: 65 RAEICSFARAVREDIDAAISCDVDSVHLVVPTSDLHLEHKLRKTREEVLEQAVDCTEYAV 124
Query: 122 DHGLKVRFTPEDTTRTEWANLKRAIRLAKELKVDRISVADTTGSTHPLRFYTLVKKIVNF 181
DHG+ V + ED+TR++ L+ R E +RI DT G P R Y + +
Sbjct: 125 DHGILVELSAEDSTRSDMDFLRTIFREGIEAGAERICACDTVGILTPERSYEFYRGLSEL 184
Query: 182 GIPVNVHCHNDLGLALANAIMGIEAGATLVDATVNGLGERAGIVDLAQIITVLYYHYGI- 240
G P++VHCHND GLA+AN++ G+ AGA+ V AT+NG+GERAG L +++ L Y +
Sbjct: 185 GAPLSVHCHNDFGLAVANSLAGLRAGASEVHATINGIGERAGNAALEEVVVALKSLYDVD 244
Query: 241 KKYRLDLLYRVSNLVSEITGISPQPNYPIVGENAFTHKAGLHVSAVLKDPRFYEFLPAEV 300
+++LY S +V+ +TG+ QPN IVGENAF H++G+H VLK YE + E+
Sbjct: 245 TSINIEMLYETSRMVARMTGVYLQPNKAIVGENAFAHESGIHADGVLKKAETYEPITPEM 304
Query: 301 FGRERTIYVDRYAGKDTIRYYLEKFGIR 328
G R + ++ G +R L++ G++
Sbjct: 305 VGHGRGFVMGKHIGTHALRKRLDELGMK 332
>sp|Q58595|YB95_METJA PUTATIVE 2-ISOPROPYLMALATE/HOMOCITRATE SYNTHASE MJ1195
>gi|2127714|pir||B64449 2-isopropylmalate synthase (EC
4.1.3.12) - Methanococcus jannaschii
>gi|1591824|gb|AAB99199.1| (U67561) 2-isopropylmalate
synthase (leuA) [Methanococcus jannaschii]
Length = 518
Score = 247 bits (624), Expect = 2e-64
Identities = 132/328 (40%), Positives = 194/328 (58%), Gaps = 2/328 (0%)
Query: 2 VLDSTLREGEQTPGVNYTPEQRLEIAIALDEVGVDFIEIGHPAVSEDVFRGMKLIAEQGL 61
+ D+TLR+GEQTPGV+ TPE++++IAI LD++GVD IE G P S +K I L
Sbjct: 26 IFDTTLRDGEQTPGVSLTPEEKIDIAIKLDDLGVDVIEAGFPVSSLGEQEAIKKICSLNL 85
Query: 62 NVELLAHSRALIEDIDYVLKTGVDWVGIFFCLSEACLRKRFRITLDHALEKISRAIEYAK 121
+ E+ +RA+ +DID + GVD + F S + + + + + ++ AIEY K
Sbjct: 86 DAEICGLARAVKKDIDVAIDCGVDRIHTFIATSPLHRKYKLKKSKEEIIDIAVDAIEYIK 145
Query: 122 DHGLKVRFTPEDTTRTEWANLKRAIRLAKELKVDRISVADTTGSTHPLRFYTLVKKI-VN 180
+HG++V F+ ED TRTE L + A + D I+V DT G P Y L+ ++
Sbjct: 146 EHGIRVEFSAEDATRTEIDYLIEVYKKAVDAGADIINVPDTVGVMIPRAMYYLINELKKE 205
Query: 181 FGIPVNVHCHNDLGLALANAIMGIEAGATLVDATVNGLGERAGIVDLAQIITVLYYHYGI 240
+P++VHCHND GLA+AN++ +EAGA V T+NGLGER G L +++ L YG+
Sbjct: 206 IKVPISVHCHNDFGLAVANSLAAVEAGAEQVHCTINGLGERGGNAALEEVVMSLMSIYGV 265
Query: 241 K-KYRLDLLYRVSNLVSEITGISPQPNYPIVGENAFTHKAGLHVSAVLKDPRFYEFLPAE 299
K + LY +S LVS+ T I QPN IVGENAF H++G+H VL YE +P E
Sbjct: 266 KTNIKTQKLYEISQLVSKYTEIKVQPNKAIVGENAFAHESGIHAHGVLAHALTYEPIPPE 325
Query: 300 VFGRERTIYVDRYAGKDTIRYYLEKFGI 327
+ G++R I + ++ G I L++ GI
Sbjct: 326 LVGQKRKIILGKHTGTHAIEAKLKELGI 353
>pir||D69064 isopropylmalate synthase - Methanobacterium thermoautotrophicum
(strain Delta H) >gi|2622597|gb|AAB85956.1| (AE000909)
isopropylmalate synthase [Methanobacterium
thermoautotrophicum]
Length = 505
Score = 247 bits (624), Expect = 2e-64
Identities = 134/328 (40%), Positives = 193/328 (57%), Gaps = 2/328 (0%)
Query: 2 VLDSTLREGEQTPGVNYTPEQRLEIAIALDEVGVDFIEIGHPAVSEDVFRGMKLIAEQGL 61
+ D+TLR+GEQTPGV T E++ IA LD +GVD IE G PA S ++ I E GL
Sbjct: 18 IFDTTLRDGEQTPGVALTVEEKTGIARKLDALGVDTIEAGFPAASPGEMNSIRRIVELGL 77
Query: 62 NVELLAHSRALIEDIDYVLKTGVDWVGIFFCLSEACLRKRFRITLDHALEKISRAIEYAK 121
+ +R L EDID + GVD++ F S + +++ D +++ +EYA
Sbjct: 78 EANICGLARVLREDIDAAIDCGVDYIHTFIGTSPLHREYKLKMSPDEIIDRAVFGVEYAA 137
Query: 122 DHGLKVRFTPEDTTRTEWANLKRAIRLAKELKVDRISVADTTGSTHPLRFYTLVKKI-VN 180
+HGLKV F+ ED TRTE+ L R A++ + I+V DT G P LV ++
Sbjct: 138 EHGLKVEFSAEDATRTEFDYLVEVYRAAEDAGAEIINVPDTVGVMIPRAMNHLVSRLKEE 197
Query: 181 FGIPVNVHCHNDLGLALANAIMGIEAGATLVDATVNGLGERAGIVDLAQIITVLYYHYGI 240
+P++VHCHND GLA+AN++ +EAGA+ V ATVNGLGERAG L +++ L Y +
Sbjct: 198 LRVPISVHCHNDFGLAVANSLAAVEAGASQVHATVNGLGERAGNAALEEVVMALITRYDL 257
Query: 241 K-KYRLDLLYRVSNLVSEITGISPQPNYPIVGENAFTHKAGLHVSAVLKDPRFYEFLPAE 299
R L +S VS+ITG+ PN IVGENAF H+AG+HV VL+ YE + E
Sbjct: 258 PVDIRTVELVNISEFVSKITGVRMPPNKAIVGENAFAHEAGIHVHGVLEKAETYEPITPE 317
Query: 300 VFGRERTIYVDRYAGKDTIRYYLEKFGI 327
+ G +R I + ++ G + +R L+++GI
Sbjct: 318 MVGHKRRIVLGKHTGANALRSKLQEYGI 345
>sp|Q57926|Y503_METJA PUTATIVE 2-ISOPROPYLMALATE/HOMOCITRATE SYNTHASE MJ0503
>gi|2127715|pir||G64362 2-isopropylmalate synthase (EC
4.1.3.12) - Methanococcus jannaschii
>gi|1591206|gb|AAB98494.1| (U67500) 2-isopropylmalate
synthase (leuA) [Methanococcus jannaschii]
Length = 406
Score = 244 bits (616), Expect = 1e-63
Identities = 148/350 (42%), Positives = 207/350 (58%), Gaps = 7/350 (2%)
Query: 2 VLDSTLREGEQTPGVNYTPEQRLEIAIALDEVGVDFIEIGHPAVSEDVFRGMKLIAEQGL 61
+ D+TLR+GEQTPGV +T EQ+LEIA LDE+G+ IE G P VSE +K IA +GL
Sbjct: 34 IYDTTLRDGEQTPGVCFTKEQKLEIARKLDELGLKQIEAGFPIVSEREADIVKTIANEGL 93
Query: 62 NVELLAHSRALIEDIDYVLKTGVDWVGIFFCLSEACLRKRF-RITLDHALEKISRAIEYA 120
N ++LA RAL +DID ++ VD + F S L+ +F +LD LE A+EYA
Sbjct: 94 NADILALCRALKKDIDKAIECDVDGIITFIATSPLHLKYKFNNKSLDEILEMGVEAVEYA 153
Query: 121 KDHGLKVRFTPEDTTRTEWANLKRAIRLAKELKVDRISVADTTGSTHP--LRFYTLVKKI 178
K+HGL V F+ ED TRT +L + + A+E DR+ +ADTTG P + F K
Sbjct: 154 KEHGLFVAFSAEDATRTPIEDLIKVHKAAEEAGADRVHIADTTGCATPQSMEFICKTLKE 213
Query: 179 VNFGIPVNVHCHNDLGLALANAIMGIEAGATLVDATVNGLGERAGIVDLAQIITVLYYHY 238
+ VHCHND G A+ N+I G+ GA V TVNG+GERAG L ++I L Y
Sbjct: 214 NLKKAHIGVHCHNDFGFAVINSIYGLIGGAKAVSTTVNGIGERAGNAALEELIMALTVLY 273
Query: 239 GIK-KYRLDLLYRVSNLVSEITGISPQPNYPIVGENAFTHKAGLHVSAVLKDPRFYE-FL 296
+ L++L + +V E +GI N PIVGE F H++G+HV AV+++P YE FL
Sbjct: 274 DVDLGLNLEVLPELCRMVEEYSGIKMPKNKPIVGELVFAHESGIHVDAVIENPLTYEPFL 333
Query: 297 PAEVFGRERTIYVDRYAGKDTIRYYLEKFGI-RDHGIVTSLLRKVKSSRE 345
P E G +R I + +++G + Y L+ GI D ++ +++KVK RE
Sbjct: 334 P-EKIGLKRNILLGKHSGCRAVAYKLKLMGIDYDREMLCEIVKKVKEIRE 382
>gb|AAK42554.1| 2-isopropylmalate synthase, putative (leuA-3) [Sulfolobus
solfataricus]
Length = 347
Score = 231 bits (584), Expect = 7e-60
Identities = 132/311 (42%), Positives = 192/311 (61%), Gaps = 13/311 (4%)
Query: 26 IAIALDEVGVDFIEIGHPAVSEDVFRGMKLIAEQ-GLNVELLAHSRALIEDIDYVLKTGV 84
IA L ++GVD IE G PA SE F + I E+ G VE++ SR+ DID + TG+
Sbjct: 2 IARKLADLGVDVIEAGFPASSEGEFIATRKIFEEIGDQVEVIGLSRSNKNDIDKTISTGI 61
Query: 85 DWVGIFFCLSEACLRKRFRITLDHALEKISRAIEYAKDHGLKVRFTPEDTTRTEWANLKR 144
+ +F SE ++ + ++T + L KI +++YAKDHG+ V F+PED TRTE L
Sbjct: 62 SSIHLFIATSELHMKYKLKMTKEEVLNKIYESVKYAKDHGMIVEFSPEDATRTEEDFLFT 121
Query: 145 AIRLAKELKVDRISVADTTGSTHPLRFYTLVKKIVNF---GIPVNVHCHNDLGLALANAI 201
AIR A E DRI++ DT G+ HP ++Y ++KKIVNF I V+VHCHND GLA AN++
Sbjct: 122 AIRTAIEAGADRINIPDTVGTMHPFKYYDMIKKIVNFVGERIIVSVHCHNDFGLATANSL 181
Query: 202 MGIEAGATLVDATVNGLGERAGIVDLAQII----TVLYYHYGIKKYRLDLLYRVSNLVSE 257
G+ AGA TVNG+GERAG L +++ +L Y +K ++ LY VS V+E
Sbjct: 182 AGVYAGARQAHVTVNGIGERAGNASLEEVVMGIKKLLNYETNVKTWK---LYEVSRFVAE 238
Query: 258 ITGISPQPNY-PIVGENAFTHKAGLHVSAVLKDPRFYEFLPAEVFGRERTIYVDRYAGKD 316
+TG+ P P + IVG+NAF H++G+HV V+++P YE + E G R + + +++G
Sbjct: 239 MTGV-PVPYFKAIVGDNAFGHESGIHVHGVIENPFTYEPISPEEVGNFRRLALGKHSGIH 297
Query: 317 TIRYYLEKFGI 327
+R LE+ GI
Sbjct: 298 GLRKLLEEQGI 308
>sp|Q9WZ23|LEU1_THEMA 2-ISOPROPYLMALATE SYNTHASE (ALPHA-ISOPROPYLMALATE SYNTHASE)
(ALPHA-IPM SYNTHETASE) >gi|7447055|pir||G72362
2-isopropylmalate synthase - Thermotoga maritima (strain
MSB8) >gi|4981068|gb|AAD35638.1|AE001730_6 (AE001730)
2-isopropylmalate synthase [Thermotoga maritima]
Length = 513
Score = 209 bits (527), Expect = 4e-53
Identities = 135/382 (35%), Positives = 204/382 (53%), Gaps = 39/382 (10%)
Query: 2 VLDSTLREGEQTPGVNYTPEQRLEIAIALDEVGVDFIEIGHPAVSEDVFRGMKLIAEQGL 61
+ D+TLR+GEQ+PG + + E+++E+A+ L+++GVD IE G P S F +K +A
Sbjct: 6 IFDTTLRDGEQSPGASMSIEEKVEMALMLEDLGVDLIEAGFPVSSPVQFEAVKRVASAVQ 65
Query: 62 NVELLAHSRALIEDIDYVLKTGVD------WVGIFFCLSEACLRKRFRITLDHALEKISR 115
++ +R + +DID + D + +F S + + R+ + LE+I R
Sbjct: 66 KPIVVGLARCVEKDIDAAYEALKDRPKDKRMIHVFIATSPIHRKYKLRMEKEEILERIRR 125
Query: 116 AIEYAKDHGLKVRFTPEDTTRTEWANLKRAIRLAKELKVDRISVADTTGSTHPLRFYTLV 175
+ YAK V F+ ED +RTE L A + A E I+V DT G P F L+
Sbjct: 126 YVGYAKQFFDLVEFSAEDASRTEVPFLIEAYKTAIEAGATTINVPDTVGYALPDEFGELI 185
Query: 176 KKIVNFGIP------VNVHCHNDLGLALANAIMGIEAGATLVDATVNGLGERAGIVDLAQ 229
K + G+P ++VHCHNDLGLA+AN++ ++ GAT V+ T+NG+GERAG L +
Sbjct: 186 KTLRE-GVPGIENVDLSVHCHNDLGLAVANSLAAVQNGATQVEVTLNGIGERAGNCALEE 244
Query: 230 IITVLY-------YHYGIKKYRLDLLYRVSNLVSEITGISPQPNYPIVGENAFTHKAGLH 282
+ +L Y GIK +L+Y S L++ ITG+ P N PIVGEN F H++G+H
Sbjct: 245 FVMILKVRKDKLPYETGIK---TELIYPASRLLTHITGLIPSRNKPIVGENVFLHESGIH 301
Query: 283 VSAVLKDPRFYEFL-PAEVFGRERTIYVDRYAGKDTIRYYLEKFGIRDHGIVTSLLRKVK 341
VLK YE + P+++ T+ + R++GK +R LE +GI K
Sbjct: 302 QDGVLKHRETYEIMKPSDIGRSSETLVLGRHSGKHALRKKLETYGI-------------K 348
Query: 342 SSREPF--TWEKLLEEARRVKE 361
E F +EK E A R KE
Sbjct: 349 LDEETFQKVFEKFTELADRKKE 370
>sp|Q12726|HOSM_YARLI HOMOCITRATE SYNTHASE, MITOCHONDRIAL PRECURSOR
>gi|1246864|emb|CAA88928.1| (Z49114) homocitrate
synthase (acetyl-coenzyme A:2-Ketoglutarate
C-acetyltransferase) [Yarrowia lipolytica]
Length = 446
Score = 206 bits (518), Expect = 4e-52
Identities = 115/331 (34%), Positives = 184/331 (54%), Gaps = 5/331 (1%)
Query: 2 VLDSTLREGEQTPGVNYTPEQRLEIAIALDEVGVDFIEIGHPAVSEDVFRGMKLIAEQGL 61
+++STLREGEQ + E ++EIA ALD+ GVD+IE+ PA SE + I + GL
Sbjct: 50 LIESTLREGEQFASAFFDTETKIEIAKALDDFGVDYIELTSPAASEQSRSDCEAICKLGL 109
Query: 62 NVELLAHSRALIEDIDYVLKTGVDWVGIFFCLSEACLRKRFRITLDHALEKISRAIEYAK 121
++L H R ++D + TGVD V + S+ + +++ + IE+ K
Sbjct: 110 KAKILTHIRCHMDDARLAVSTGVDGVDVVIGTSQFLRQYSHGKDMNYIAQSAVEVIEFVK 169
Query: 122 DHGLKVRFTPEDTTRTEWANLKRAIRLAKELKVDRISVADTTGSTHPLRFYTLVKKIVN- 180
HG+++RF+ ED+ R++ +L R ++ V+R+ +ADT G +P + Y LV+ + +
Sbjct: 170 SHGIEIRFSSEDSFRSDLVDLLNIYRTVDKIGVNRVGIADTVGCANPRQVYELVRTLKSV 229
Query: 181 FGIPVNVHCHNDLGLALANAIMGIEAGATLVDATVNGLGERAGIVDLAQIITVLY---YH 237
+ H HND G A+ANA +EAGA L+D +V G+GER GI L ++ +
Sbjct: 230 VSCDIECHFHNDTGCAIANAYTALEAGANLIDVSVLGIGERNGITSLGGLMARMIAADRD 289
Query: 238 YGIKKYRLDLLYRVSNLVSEITGISPQPNYPIVGENAFTHKAGLHVSAVLKDPRFYEFLP 297
Y + KY+L L + NLV++ ++ N PI G AFTHKAG+H A+L +P YE L
Sbjct: 290 YVLSKYKLHKLRDLENLVADAVQVNIPFNNPITGFCAFTHKAGIHAKAILANPSTYEILN 349
Query: 298 AEVFGRERTI-YVDRYAGKDTIRYYLEKFGI 327
FG R I + +R G + I+ +++ +
Sbjct: 350 PADFGLTRYIHFANRLTGWNAIKSRVDQLNL 380
>emb|CAB91069.1| (AJ239033) homocitrate sythase 1 [Anabaena variabilis]
Length = 381
Score = 203 bits (510), Expect = 4e-51
Identities = 127/367 (34%), Positives = 197/367 (53%), Gaps = 7/367 (1%)
Query: 1 MVLDSTLREGEQTPGVNYTPEQRLEIAIALDEVGVDFIEIGHPAVSEDVFRGMKLIAEQG 60
++ D+TLR+GEQ GV +T E+++ IA LD +GV +E+G PA+ E+ R + I+ G
Sbjct: 5 LINDTTLRDGEQAAGVVFTLEEKVAIAKFLDTIGVPELEVGIPAMGEEEMRAICAISNLG 64
Query: 61 LNVELLAHSRALIEDIDYVLKTGVDWVGIFFCLSEACLRKRFRITLDHALEKISRAIEYA 120
L LLA +RA+I DI + G++ V I +S + +F +L+++ I +A
Sbjct: 65 LKANLLAWNRAVISDIKASVACGMERVHIAIPVSGIQIAAKFHGQWRVSLQRLKDCISFA 124
Query: 121 KDHGLKVRFTPEDTTRTEWANLKRAIRLAKELKVDRISVADTTGSTHPLRFYTLVKKIVN 180
D GL V ED++R + L A+E R DT G P Y VK +V+
Sbjct: 125 VDQGLWVAVGGEDSSRADENFLLDVALYAQEWGASRFRFCDTVGVLDPFTTYGKVKLLVS 184
Query: 181 -FGIPVNVHCHNDLGLALANAIMGIEAGATLVDATVNGLGERAGIVDLAQIITVLYYHYG 239
IPV VH HND G+A ANA+ GI+AGA V+ TV GLGERAG L +++ + YG
Sbjct: 185 ALTIPVEVHTHNDFGMATANALAGIKAGAASVNTTVIGLGERAGNAALEEVVMAIKRIYG 244
Query: 240 IKK-YRLDLLYRVSNLVSEITGISPQPNYPIVGENAFTHKAGLHVSAVLKDPRFYEFLPA 298
+ L +S LV+ +G + P IVGEN F H++G+H VL++P YE
Sbjct: 245 VDMGIDTPRLLELSQLVAAASGANVPPWKAIVGENTFAHESGIHAHGVLQNPDTYEPFAP 304
Query: 299 EVFGRERTIYVDRYAGKDTIRYYLEKFGI-----RDHGIVTSLLRKVKSSREPFTWEKLL 353
E G ER + V +++G+ ++ LE+ GI ++ ++ ++ + T E+LL
Sbjct: 305 EEVGWERRLVVGKHSGRHSVSNLLEQHGIFLNPEETQSVLDAVRQQSVKKKRSLTTEELL 364
Query: 354 EEARRVK 360
+R +
Sbjct: 365 NLGQRTE 371
>pir||T39279 probable homocitrate synthase (EC 4.1.3.21), mitochondrial isozyme
precursor - fission yeast (Schizosaccharomyces pombe)
>gi|5531464|emb|CAB50965.1| (AL096851) probable
homocitrate synthase, mitochondrial isozyme precursor(ec
4.1.3.21) [Schizosaccharomyces pombe]
Length = 418
Score = 202 bits (508), Expect = 6e-51
Identities = 111/331 (33%), Positives = 182/331 (54%), Gaps = 5/331 (1%)
Query: 2 VLDSTLREGEQTPGVNYTPEQRLEIAIALDEVGVDFIEIGHPAVSEDVFRGMKLIAEQGL 61
+++STLREGEQ + E++++IA ALD GVD+IE+ P SE + + I + GL
Sbjct: 37 IIESTLREGEQFANAFFDTEKKIQIAKALDNFGVDYIELTSPVASEQSRQDCEAICKLGL 96
Query: 62 NVELLAHSRALIEDIDYVLKTGVDWVGIFFCLSEACLRKRFRITLDHALEKISRAIEYAK 121
++L H R ++D ++TGVD V + S+ + + + ++ + I + K
Sbjct: 97 KCKILTHIRCHMDDARVAVETGVDGVDVVIGTSQYLRKYSHGKDMTYIIDSATEVINFVK 156
Query: 122 DHGLKVRFTPEDTTRTEWANLKRAIRLAKELKVDRISVADTTGSTHPLRFYTLVKKIVN- 180
G++VRF+ ED+ R++ +L + ++ V+R+ +ADT G P + Y L++ +
Sbjct: 157 SKGIEVRFSSEDSFRSDLVDLLSLYKAVDKIGVNRVGIADTVGCATPRQVYDLIRTLRGV 216
Query: 181 FGIPVNVHCHNDLGLALANAIMGIEAGATLVDATVNGLGERAGIVDLAQIITVLYY---H 237
+ H HND G+A+ANA +EAGAT +D ++ G+GER GI L ++ +Y
Sbjct: 217 VSCDIECHFHNDTGMAIANAYCALEAGATHIDTSILGIGERNGITPLGALLARMYVTDRE 276
Query: 238 YGIKKYRLDLLYRVSNLVSEITGISPQPNYPIVGENAFTHKAGLHVSAVLKDPRFYEFLP 297
Y KY+L+ L + NLV++ + N I G AFTHKAG+H A+L +P YE L
Sbjct: 277 YITHKYKLNQLRELENLVADAVEVQIPFNNYITGMCAFTHKAGIHAKAILANPSTYEILK 336
Query: 298 AEVFGRERTIYV-DRYAGKDTIRYYLEKFGI 327
E FG R ++V R G + I+ E+ +
Sbjct: 337 PEDFGMSRYVHVGSRLTGWNAIKSRAEQLNL 367
>pir||F75391 2-isopropylmalate synthase - Deinococcus radiodurans (strain R1)
>gi|6459240|gb|AAF11047.1|AE001992_7 (AE001992)
2-isopropylmalate synthase [Deinococcus radiodurans]
Length = 522
Score = 201 bits (507), Expect = 8e-51
Identities = 121/341 (35%), Positives = 182/341 (52%), Gaps = 14/341 (4%)
Query: 2 VLDSTLREGEQTPGVNYTPEQRLEIAIALDEVGVDFIEIGHPAVSEDVFRGMKLIAEQGL 61
+ D+TLR+GEQ+PGV Q+LEIA L +GVD IE G P S G+ IA +
Sbjct: 18 IFDTTLRDGEQSPGVALNHAQKLEIAHTLARMGVDVIEAGFPIASPGDLEGVSRIAREVR 77
Query: 62 NVELLAHSRALIEDIDYVLKTGVDW-----VGIFFCLSEACLRKRFRITLDHALEKISRA 116
+ A +RA DI+ K GV+ + F S ++K+ + D +E+ A
Sbjct: 78 GPVITALARANRADIEAAAK-GVEAAEKSRIHTFIATSPIHMQKKLNLEPDAVIERAVEA 136
Query: 117 IEYAKDHGLKVRFTPEDTTRTEWANLKRAIRLAKELKVDRISVADTTGSTHP---LRFYT 173
+ A+ + V F+ ED TR+EW L R + A E I+V DT G T P + +
Sbjct: 137 VRLARQYVDDVEFSAEDATRSEWDFLSRIFKAAVEAGATTINVPDTVGYTTPEEMRKLFA 196
Query: 174 LVKKIVNFGIPVNVHCHNDLGLALANAIMGIEAGATLVDATVNGLGERAGIVDLAQIITV 233
+K + + ++ HCH+DLG+A+AN+I E GA ++ T+NG+GERAG L +I+
Sbjct: 197 YLKAKLPAHVILSSHCHDDLGMAVANSIAAAEGGARQIECTINGIGERAGNASLEEIVMA 256
Query: 234 LYYHYGIKKYRLDL----LYRVSNLVSEITGISPQPNYPIVGENAFTHKAGLHVSAVLKD 289
+ + Y + LYR S LVS ++G+ QPN IVG+NAF H++G+H V+K
Sbjct: 257 FHTRRDVYGYETGIRTRELYRASRLVSRLSGMPVQPNKAIVGDNAFAHESGIHQDGVIKA 316
Query: 290 PRFYEFLPAEVFGRERTIYV-DRYAGKDTIRYYLEKFGIRD 329
YE + AE+ GRE + V +++G+ R L G D
Sbjct: 317 RETYEIMNAELVGREAAVLVMGKHSGRAAFRKALTDLGYGD 357
>gi|6320019 homocitrate synthase, highly homologous to YDL131W; Lys20p
[Saccharomyces cerevisiae]
>gi|1351812|sp|P48570|HOSC_YEAST HOMOCITRATE SYNTHASE,
CYTOSOLIC ISOZYME >gi|2131289|pir||S58735 homocitrate
synthase homolog YDL182w - yeast (Saccharomyces
cerevisiae) >gi|1004312|emb|CAA58264.1| (X83276) D1298
[Saccharomyces cerevisiae] >gi|1431295|emb|CAA98757.1|
(Z74230) ORF YDL182w [Saccharomyces cerevisiae]
Length = 428
Score = 201 bits (506), Expect = 1e-50
Identities = 111/331 (33%), Positives = 184/331 (55%), Gaps = 5/331 (1%)
Query: 2 VLDSTLREGEQTPGVNYTPEQRLEIAIALDEVGVDFIEIGHPAVSEDVFRGMKLIAEQGL 61
++DSTLREGEQ + E+++EIA ALD+ GVD+IE+ P SE + + I + GL
Sbjct: 25 LIDSTLREGEQFANAFFDTEKKIEIARALDDFGVDYIELTSPVASEQSRKDCEAICKLGL 84
Query: 62 NVELLAHSRALIEDIDYVLKTGVDWVGIFFCLSEACLRKRFRITLDHALEKISRAIEYAK 121
++L H R ++D ++TGVD V + S+ + +++ + IE+ K
Sbjct: 85 KAKILTHIRCHMDDAKVAVETGVDGVDVVIGTSKFLRQYSHGKDMNYIAKSAVEVIEFVK 144
Query: 122 DHGLKVRFTPEDTTRTEWANLKRAIRLAKELKVDRISVADTTGSTHPLRFYTLVKKIVN- 180
G+++RF+ ED+ R++ +L + ++ V+R+ +ADT G +P + Y L++ + +
Sbjct: 145 SKGIEIRFSSEDSFRSDLVDLLNIYKTVDKIGVNRVGIADTVGCANPRQVYELIRTLKSV 204
Query: 181 FGIPVNVHCHNDLGLALANAIMGIEAGATLVDATVNGLGERAGIVDLAQIIT---VLYYH 237
+ H HND G A+ANA +E GA L+D +V G+GER GI L ++ V
Sbjct: 205 VSCDIECHFHNDTGCAIANAYTALEGGARLIDVSVLGIGERNGITPLGGLMARMIVAAPD 264
Query: 238 YGIKKYRLDLLYRVSNLVSEITGISPQPNYPIVGENAFTHKAGLHVSAVLKDPRFYEFLP 297
Y KY+L + + NLV++ ++ N PI G AFTHKAG+H A+L +P YE L
Sbjct: 265 YVKSKYKLHKIRDIENLVADAVEVNIPFNNPITGFCAFTHKAGIHAKAILANPSTYEILD 324
Query: 298 AEVFGRERTI-YVDRYAGKDTIRYYLEKFGI 327
FG +R I + +R G + I+ +++ +
Sbjct: 325 PHDFGMKRYIHFANRLTGWNAIKARVDQLNL 355
>gi|6320071 homocitrate synthase, highly homologous to YDL182W; Lys21p
[Saccharomyces cerevisiae]
>gi|2492788|sp|Q12122|HOSM_YEAST HOMOCITRATE SYNTHASE,
MITOCHONDRIAL PRECURSOR >gi|2131288|pir||S67674
homocitrate synthase homolog YDL131w - yeast
(Saccharomyces cerevisiae) >gi|1419231|emb|CAA65629.1|
(X96876) putative ORF [Saccharomyces cerevisiae]
>gi|1431199|emb|CAA98700.1| (Z74179) ORF YDL131w
[Saccharomyces cerevisiae]
Length = 440
Score = 201 bits (505), Expect = 1e-50
Identities = 111/331 (33%), Positives = 184/331 (55%), Gaps = 5/331 (1%)
Query: 2 VLDSTLREGEQTPGVNYTPEQRLEIAIALDEVGVDFIEIGHPAVSEDVFRGMKLIAEQGL 61
++DSTLREGEQ + E+++EIA ALD+ GVD+IE+ P SE + + I + GL
Sbjct: 39 LIDSTLREGEQFANAFFDTEKKIEIARALDDFGVDYIELTSPVASEQSRKDCEAICKLGL 98
Query: 62 NVELLAHSRALIEDIDYVLKTGVDWVGIFFCLSEACLRKRFRITLDHALEKISRAIEYAK 121
++L H R ++D ++TGVD V + S+ + +++ + IE+ K
Sbjct: 99 KAKILTHIRCHMDDARVAVETGVDGVDVVIGTSKFLRQYSHGKDMNYIAKSAVEVIEFVK 158
Query: 122 DHGLKVRFTPEDTTRTEWANLKRAIRLAKELKVDRISVADTTGSTHPLRFYTLVKKIVN- 180
G+++RF+ ED+ R++ +L + ++ V+R+ +ADT G +P + Y L++ + +
Sbjct: 159 SKGIEIRFSSEDSFRSDLVDLLNIYKTVDKIGVNRVGIADTVGCANPRQVYELIRTLKSV 218
Query: 181 FGIPVNVHCHNDLGLALANAIMGIEAGATLVDATVNGLGERAGIVDLAQIIT---VLYYH 237
+ H HND G A+ANA +E GA L+D +V G+GER GI L ++ V
Sbjct: 219 VSCDIECHFHNDTGCAIANAYTALEGGARLIDVSVLGIGERNGITPLGGLMARMIVAAPD 278
Query: 238 YGIKKYRLDLLYRVSNLVSEITGISPQPNYPIVGENAFTHKAGLHVSAVLKDPRFYEFLP 297
Y KY+L + + NLV++ ++ N PI G AFTHKAG+H A+L +P YE L
Sbjct: 279 YVRSKYKLHKIRDIENLVADAVEVNIPFNNPITGFCAFTHKAGIHAKAILANPSTYEILD 338
Query: 298 AEVFGRERTI-YVDRYAGKDTIRYYLEKFGI 327
FG +R I + +R G + I+ +++ +
Sbjct: 339 PHDFGMKRYIHFANRLTGWNAIKSRVDQLNL 369
>pir||A75045 2-isopropylmalate synthase (leua-1) PAB0890 - Pyrococcus abyssi
(strain Orsay) >gi|5458767|emb|CAB50254.1| (AJ248287)
2-isopropylmalate synthase (leuA-1) [Pyrococcus abyssi]
Length = 486
Score = 200 bits (504), Expect = 2e-50
Identities = 123/339 (36%), Positives = 186/339 (54%), Gaps = 14/339 (4%)
Query: 2 VLDSTLREGEQTPGVNYTPEQRLEIAIALDEVGVDFIEIGHPAVSEDVFRGMKLIAEQGL 61
+ D+TLR+GEQTPGV+ T E+++EIA L ++ VD IE G P SE F+ +K IA +
Sbjct: 6 IFDTTLRDGEQTPGVSLTVEEKVEIAKQLAKLNVDVIEAGFPIASEGEFKAVKKIATEVE 65
Query: 62 NVELLAHSRALIEDID----YVLKTGVDWVGIFFCLSEACLRKRFRITLDHALEKISRAI 117
+ + A +RA+ +DID + + + F S ++ + R + + +A+
Sbjct: 66 DPTIAALARAVEKDIDRAGEALRNAEKNRIHTFIATSPIHMKYKLRKEPEEVKKLAVKAV 125
Query: 118 EYAKDHGLKVRFTPEDTTRTEWANLKRAIRLAKELKVDRISVADTTGSTHPLRFYTLV-- 175
E+A + V F+ ED TR++W L + I+V DT G P FY LV
Sbjct: 126 EHATKYTEDVEFSAEDATRSDWDFLVEVYEAVIDAGATVINVPDTVGYATPEEFYELVRY 185
Query: 176 --KKIVNF-GIPVNVHCHNDLGLALANAIMGIEAGATLVDATVNGLGERAGIVDLAQIIT 232
+ I N G+ ++VHCH+DLGLA+AN++ I AGA V+ TVNG+GERAG L ++I
Sbjct: 186 LRRNISNIKGVQISVHCHDDLGLAVANSLSAIRAGADQVEVTVNGIGERAGNAALEEVIV 245
Query: 233 VLYYHYGIKKYRLDL----LYRVSNLVSEITGISPQPNYPIVGENAFTHKAGLHVSAVLK 288
L K + D+ + R S LVS +TGI PN IVG NAF H++G+H VLK
Sbjct: 246 ALDVRRDFYKVKTDVNLKEIARTSKLVSHLTGIEVPPNKAIVGGNAFAHESGIHQDGVLK 305
Query: 289 DPRFYEFLPAEVFGRERT-IYVDRYAGKDTIRYYLEKFG 326
+ YE + + G + I + +++G+ R LE+ G
Sbjct: 306 ERTTYEIIDPKKLGFSGSKIVLGKHSGRHAFRKKLEELG 344
>sp|O87198|HOSC_THETH HOMOCITRATE SYNTHASE >gi|11268243|pir||T51170 homocitrate synthase
(EC 4.1.3.21) [validated] - Thermus aquaticus
>gi|3724367|dbj|BAA33785.1| (AB018379) homocitrate
synthase [Thermus thermophilus]
Length = 376
Score = 199 bits (502), Expect = 3e-50
Identities = 118/335 (35%), Positives = 188/335 (55%), Gaps = 11/335 (3%)
Query: 2 VLDSTLREGEQTPGVNYTPEQRLEIAIALDEVGVDFIEIGHPAVSEDVFRGMKLIAEQGL 61
++DSTLREGEQ N++ + ++EIA ALDE G+++IE+ P S + +++A GL
Sbjct: 6 IIDSTLREGEQFEKANFSTQDKVEIAKALDEFGIEYIEVTTPVASPQSRKDAEVLASLGL 65
Query: 62 NVELLAHSRALIEDIDYVLKTGVDWVGIFFCLSEACLRKRFRITLDHALEKISRAIEYAK 121
+++ H + ++ ++TGV + + F S+ LR + +E+ I Y +
Sbjct: 66 KAKVVTHIQCRLDAAKVAVETGVQGIDLLFGTSK-YLRAPHGRDIPRIIEEAKEVIAYIR 124
Query: 122 DHG--LKVRFTPEDTTRTEWANLKRAIRLAKELKVDRISVADTTGSTHPLRFYTL---VK 176
+ ++VRF+ EDT R+E +L A+ A VDR+ +ADT G P + Y L V+
Sbjct: 125 EAAPHVEVRFSAEDTFRSEEQDL-LAVYEAVAPYVDRVGLADTVGVATPRQVYALVREVR 183
Query: 177 KIVNFGIPVNVHCHNDLGLALANAIMGIEAGATLVDATVNGLGERAGIVDLAQIITVLYY 236
++V + + H HND G A+ANA IEAGAT VD T+ G+GER GI L + +Y
Sbjct: 184 RVVGPRVDIEFHGHNDTGCAIANAYEAIEAGATHVDTTILGIGERNGITPLGGFLARMYT 243
Query: 237 ---HYGIKKYRLDLLYRVSNLVSEITGISPQPNYPIVGENAFTHKAGLHVSAVLKDPRFY 293
Y +KY+L++L + +V+ + G+ N I GE AF+HKAG+H+ A+ +P Y
Sbjct: 244 LQPEYVRRKYKLEMLPELDRMVARMVGVEIPFNNYITGETAFSHKAGMHLKAIYINPEAY 303
Query: 294 EFLPAEVFG-RERTIYVDRYAGKDTIRYYLEKFGI 327
E P EVFG + + I R G+ I+ E+ G+
Sbjct: 304 EPYPPEVFGVKRKLIIASRLTGRHAIKARAEELGL 338
>pir||D75418 homocitrate synthase - Deinococcus radiodurans (strain R1)
>gi|6458984|gb|AAF10811.1|AE001972_1 (AE001972)
homocitrate synthase [Deinococcus radiodurans]
Length = 393
Score = 199 bits (501), Expect = 4e-50
Identities = 117/335 (34%), Positives = 180/335 (52%), Gaps = 9/335 (2%)
Query: 2 VLDSTLREGEQTPGVNYTPEQRLEIAIALDEVGVDFIEIGHPAVSEDVFRGMKLIAEQGL 61
++DSTLREGEQ N+ + ++EIA ALD G ++IE+ P VSE + ++ + GL
Sbjct: 21 IIDSTLREGEQFARGNFGTDDKVEIARALDAFGAEYIEVTTPMVSEQTRQDIRKLTGLGL 80
Query: 62 NVELLAHSRALIEDIDYVLKTGVDWVGIFFCLSEACLRKRFRITLDHALEKISRAIEYAK 121
+ L H R +ED+ + TGVD + + F S ++ ++ I + K
Sbjct: 81 RAKFLTHVRCHMEDVQRAVDTGVDGLDLLFGTSSFLREFSHGKSIAQIIDTAGEVIGWIK 140
Query: 122 DH--GLKVRFTPEDTTRTEWANLKRAIRLAKELKVDRISVADTTGSTHPLRFYTL---VK 176
H L++RF+ EDT R+E A+L EL V R+ +ADT G P + YTL V+
Sbjct: 141 THHPELEIRFSAEDTFRSEEADLMAVYSAVSELGVHRVGLADTVGVATPRQVYTLVREVR 200
Query: 177 KIVNFGIPVNVHCHNDLGLALANAIMGIEAGATLVDATVNGLGERAGIVDLAQIITVLYY 236
K+++ G + H HND G A++NA IEAGAT +D T+ G+GER GI L ++ ++
Sbjct: 201 KVIHEGCGIEFHGHNDTGCAVSNAYEAIEAGATHIDTTILGIGERNGITPLGGLLARMFT 260
Query: 237 HYG---IKKYRLDLLYRVSNLVSEITGISPQPNYPIVGENAFTHKAGLHVSAVLKDPRFY 293
I KY L+LL + +++ + + N + GE A+ HKAG+H+ A+ +P Y
Sbjct: 261 FDPQGLIDKYNLELLPELDRMIARMVDLPVPWNNYLTGEFAYNHKAGMHLKAIYLNPGAY 320
Query: 294 EFLPAEVFGRERTIY-VDRYAGKDTIRYYLEKFGI 327
E +P VFG R I + GK I Y + G+
Sbjct: 321 EAIPPGVFGVGRRIQAASKVTGKHAIAYKARELGL 355
>gb|AAF13763.1|AF117351_20 (AF117351) homocitrate synthase [Zymomonas mobilis]
Length = 386
Score = 199 bits (500), Expect = 5e-50
Identities = 120/345 (34%), Positives = 188/345 (53%), Gaps = 4/345 (1%)
Query: 1 MVLDSTLREGEQTPGVNYTPEQRLEIAIALDEVGVDFIEIGHPAVSEDVFRGMKLIAEQG 60
++ D+TLR+GEQ PGV +T ++L IA ALD+ GVD IE G PA+ ++ I +Q
Sbjct: 10 IINDTTLRDGEQAPGVAFTLSEKLHIAKALDKAGVDEIEAGIPAMGASEIEAIRQIVQQS 69
Query: 61 LNVELLAHSRALIEDIDYVLKTGVDWVGIFFCLSEACLRKRF-RITLDHALEKISRAIEY 119
++ R I D+D L+TG V + S + +F ++ L + I Y
Sbjct: 70 QTARVIPWCRMKISDVDKALETGAKTVHLSISSSPFQMAAKFPDLSAADILGLCQKVISY 129
Query: 120 AKDHGLKVRFTPEDTTRTEWANLKRAIRLAKELKVDRISVADTTGSTHPLRFYTLVKKIV 179
AKD GL+V ED +R E + L + + +E RI ADT G P Y ++ ++
Sbjct: 130 AKDRGLEVSVGAEDASRAEISFLTDLLGVIEEAGAFRIRFADTLGILDPFATYEIISQLH 189
Query: 180 NFG-IPVNVHCHNDLGLALANAIMGIEAGATLVDATVNGLGERAGIVDLAQIITVLYYHY 238
+ + H H+DLGLA AN++ I+AGA TV GLGERAG L Q++ +
Sbjct: 190 QISPLDIEFHGHDDLGLATANSLAAIKAGAKGASVTVLGLGERAGNASLEQVVIAASHIA 249
Query: 239 GIK-KYRLDLLYRVSNLVSEITGISPQPNYPIVGENAFTHKAGLHVSAVLKDPRFYEFLP 297
G + + R + LY ++ V++ G + P+ IVGE F H++G+HV+ +L++P YE L
Sbjct: 250 GKETRIRPEKLYNLAQYVAQAAGRTIPPDKAIVGEAVFQHESGIHVAGLLRNPASYEALN 309
Query: 298 AEVFGRERTIYVDRYAGKDTIRYYLEKFGIR-DHGIVTSLLRKVK 341
E GR+R I + +++G+ IR+ L GI+ ++ +LL VK
Sbjct: 310 PEKLGRQREIVLGKHSGRAAIRHALSLLGIKAQEDMIQNLLAAVK 354
>emb|CAB91068.1| (AJ239032) homocitrate synthase 2 [Anabaena variabilis]
Length = 379
Score = 197 bits (495), Expect = 2e-49
Identities = 121/320 (37%), Positives = 179/320 (55%), Gaps = 8/320 (2%)
Query: 1 MVLDSTLREGEQTPGVNYTPEQRLEIAIALDEVGVDFIEIGHPAVSEDVFRGMKLIAEQG 60
++ D+TLR+GEQ GV ++ E+++ IA LD +GVD IE+G PA+ + + I +
Sbjct: 5 LINDTTLRDGEQAAGVAFSVEEKIAIAKFLDAIGVDEIEVGIPAMGKAEQEAIANIVKLN 64
Query: 61 LNVELLAHSRALIEDIDYVLKTGVDWVGIFFCLSEACLRKRFRITLDHALEKISRAIEYA 120
L+ LL +RA+I DI + G+ V I +S + +F L+K+ +I +A
Sbjct: 65 LSANLLGWNRAVISDIQASIACGLQRVHISIPVSAIQIAAKFHGQWQVVLQKLHDSISFA 124
Query: 121 KDHGLKVRFTPEDTTRTEWANLKRAIRLAKELKVDRISVADTTGSTHPLRFYTLVKKIV- 179
D GL V ED++R E + L + A+E R DT G P + +K++V
Sbjct: 125 VDQGLFVSIGGEDSSRAEESFLLDVVLAAQEWGALRFRFCDTVGILDPFTTHAKIKQLVA 184
Query: 180 NFGIPVNVHCHNDLGLALANAIMGIEAGATLVDATVNGLGERAGIVDLAQIITV---LYY 236
+ IPV +H HND GLA ANA+ GI+AGA V+ TVNGLGERAG L +++ LY+
Sbjct: 185 SLTIPVEMHTHNDFGLATANALAGIKAGALSVNTTVNGLGERAGNAALEEVVMALKHLYH 244
Query: 237 H-YGIKKYRLDLLYRVSNLVSEITGISPQPNYPIVGENAFTHKAGLHVSAVLKDPRFYEF 295
H GI R L +S LV +G P IVGEN F H++G+H VL++P+ YE
Sbjct: 245 HDLGIDTRR---LLEISQLVVSASGHPVPPWKAIVGENTFAHESGIHAHGVLQNPQTYEP 301
Query: 296 LPAEVFGRERTIYVDRYAGK 315
E GRER + V +++G+
Sbjct: 302 FAPEEVGRERRLVVGKHSGR 321
>gb|AAK40481.1| 2-isopropylmalate synthase, putative (leuA-1) [Sulfolobus
solfataricus]
Length = 553
Score = 196 bits (493), Expect = 3e-49
Identities = 122/343 (35%), Positives = 182/343 (52%), Gaps = 17/343 (4%)
Query: 2 VLDSTLREGEQTPGVNYTPEQRLEIAIALDEVGVDFIEIGHPAVS---EDVFRGMKLIAE 58
VLD+TLR+G Q +++T +++IA+ LDE+GVD+IE G P + E+ FR +K
Sbjct: 35 VLDTTLRDGSQGANISFTLNDKIKIALLLDELGVDYIEGGWPGSNPKDEEFFREIKKYRL 94
Query: 59 QGLNVELLAHSR----ALIEDIDY--VLKTGVDWVGIFFCLSEACLRKRFRITLDHALEK 112
+ ++ ++ EDI ++K VD IF + ++T L+
Sbjct: 95 SKAKIAAFGSTKRKDVSVKEDISLNSIVKADVDVAVIFGKSWSLHATEVLKVTKQDNLDI 154
Query: 113 ISRAIEYAKDHGLKVRFTPEDTTRTEWANLKRAIRLAKELK---VDRISVADTTGSTHPL 169
+ +I Y K HGLKV F E + + + A+ + K + D I++ADT G T P
Sbjct: 155 VYDSINYLKSHGLKVIFDAEHFYQGFKEDPEYALEVVKTAESAGADVIALADTNGGTPPF 214
Query: 170 RFYTLVKKIVN-FGIPVNVHCHNDLGLALANAIMGIEAGATLVDATVNGLGERAGIVDLA 228
Y + KK+ + + +H HND+G A+AN++M I+AGA V T+NG+GER G DL
Sbjct: 215 EVYEITKKVREVLQVKLGIHAHNDIGCAVANSLMAIKAGARHVQGTINGIGERTGNADLI 274
Query: 229 QIITVLYYHYGIKKYR----LDLLYRVSNLVSEITGISPQPNYPIVGENAFTHKAGLHVS 284
QII L G+ L L VS +V EI G+ P P P VG+NAF HKAG+HV
Sbjct: 275 QIIPTLILKMGLNALNGQESLRKLREVSRIVYEILGLPPNPYQPYVGDNAFAHKAGVHVD 334
Query: 285 AVLKDPRFYEFLPAEVFGRERTIYVDRYAGKDTIRYYLEKFGI 327
AV+K PR YE + + G +R + +G + YL+ GI
Sbjct: 335 AVMKVPRAYEHVDPSLVGNDRKFVISELSGTANLVSYLQGLGI 377
>gi|10954450 isopropylmalate synthase [Buchnera aphidicola]
>gi|3282732|gb|AAD12593.1| (AF041836) isopropylmalate
synthase [Buchnera aphidicola]
Length = 518
Score = 191 bits (481), Expect = 9e-48
Identities = 116/373 (31%), Positives = 201/373 (53%), Gaps = 27/373 (7%)
Query: 1 MVLDSTLREGEQTPGVNYTPEQRLEIAIALDEVGVDFIEIGHPAVSEDVFRGMKLIAEQG 60
++ D+TLR+GEQ + + +Q+L+IA++L+ G+D IE+G P S F+ ++ I++
Sbjct: 6 IIFDTTLRDGEQALQASLSVKQKLQIALSLENAGIDIIEVGFPISSPGDFKSVQTISKNI 65
Query: 61 LNVELLAHSRALIEDIDYVLK----TGVDWVGIFFCLS----EACLRKRFRITLDHALEK 112
N + + +R L +DID + + + IF S E+ L+K F +D A+
Sbjct: 66 KNSRICSLARCLNKDIDTAAEAMSSSNTFRIHIFLATSTLHMESKLKKNFDQIIDMAISS 125
Query: 113 ISRAIEYAKDHGLKVRFTPEDTTRTEWANLKRAIRLAKELKVDRISVADTTGSTHPLRFY 172
+ RA+ Y D V F+ ED +RT NL R + + V I++ DT G T P
Sbjct: 126 VKRALRYTDD----VEFSCEDASRTTMDNLCRIVEQLIKAGVKTINIPDTVGYTVPNELS 181
Query: 173 TLV----KKIVNFGIPV-NVHCHNDLGLALANAIMGIEAGATLVDATVNGLGERAGIVDL 227
T++ K++ N + +VHCHNDLG+A+ N+I I+AGA ++ T+NG+GERAG L
Sbjct: 182 TIIHNLFKRVPNIDQSIISVHCHNDLGMAVGNSISAIQAGARQIEGTINGIGERAGNTAL 241
Query: 228 AQIITVLYYHYGIKKYRLDL----LYRVSNLVSEITGISPQPNYPIVGENAFTHKAGLHV 283
++I + I ++ +YR S ++S+I + PN IVG NAF H +G+H
Sbjct: 242 EEVIMAIKVREDILGVSTNIKHKEIYRTSQIISQICNLPIPPNKAIVGSNAFAHSSGIHQ 301
Query: 284 SAVLKDPRFYEFL-PAEVFGRERTIYVDRYAGKDTIRYYLEKFGIRD-----HGIVTSLL 337
VLK+ + YE + P+ + +E + + +G+ ++YY+ + G ++ + TS L
Sbjct: 302 DGVLKNRKNYEIMEPSSIGLKEVKLNLTSRSGRAAVKYYMTQMGYKECDYNIDELYTSFL 361
Query: 338 RKVKSSREPFTWE 350
+ + F ++
Sbjct: 362 KLADKKGQVFDYD 374
>pir||C83494 probable 2-isopropylmalate synthase PA1217 [imported] - Pseudomonas
aeruginosa (strain PAO1)
>gi|9947145|gb|AAG04606.1|AE004551_10 (AE004551)
probable 2-isopropylmalate synthase [Pseudomonas
aeruginosa]
Length = 455
Score = 191 bits (481), Expect = 9e-48
Identities = 117/328 (35%), Positives = 177/328 (53%), Gaps = 8/328 (2%)
Query: 2 VLDSTLREGEQTPGVNYTPEQRLEIAIALDEVGVDFIEIGHPAVSEDVFRGMKLIAEQGL 61
V+D TLREG Q ++ Q +++A + +GVD IE GHP +S D ++ + +
Sbjct: 4 VIDCTLREGCQARQCSFDSAQSVQLAREIAALGVDMIECGHPRISADERERVRAVVA-AV 62
Query: 62 NVELLAHSRALIEDIDYVLKTGVDWVGIFFCLSEACLRKRFR-ITLDHALEKISRAIEYA 120
+ +LAH+RA EDID VL+TG WVG+F ++ L +F+ + + LE AI YA
Sbjct: 63 STPVLAHARARREDIDAVLETGAQWVGLFASINAISLETKFKGMNREEVLELFHDAIRYA 122
Query: 121 KDHGLKVRFTPEDTTRTEWANLKRAIRLAKELKVDRISVADTTGSTHPLRFYTLVKKIVN 180
++ GL+VR T ED RT ++L I A++ DRI AD+ G P + ++ + +
Sbjct: 123 RERGLRVRATVEDAARTSVSDLVSMIATARDAGADRICFADSVGILLPDETFDVLSLLRH 182
Query: 181 F--GIPVNVHCHNDLGLALANAIMGIEAGATLVDATVNGLGERAGIVDLAQIITVLYYHY 238
+ H HND GLAL N + I+AG A+ NG+GERAGI D Q++T+L+ +
Sbjct: 183 EFPDVVFEYHVHNDRGLALGNTLAAIQAGVQWHSASCNGIGERAGITDTFQLLTLLHTKF 242
Query: 239 GIKKYRLDLLYRVSNLVSEITGISPQPNYPIVGENAFTHKAGLHVSAVLKDPRFYE-FLP 297
++ L + VS LV + I P +P+VGENAF H A LH A+ ++ Y F P
Sbjct: 243 AADRFNLKNVLAVSELVEAHSRIKRSPMHPVVGENAFVHVARLHQLAMQENQDAYSAFDP 302
Query: 298 AEVFGRERTIYVDRYAGKDTIRYYLEKF 325
+ GR + + RY +L F
Sbjct: 303 ELINGR---VSLQRYTPMHRQSLFLTPF 327
>sp|O94225|HOSM_PENCH HOMOCITRATE SYNTHASE, MITOCHONDRIAL PRECURSOR
>gi|4165570|emb|CAA11503.1| (AJ223630) homocitrate
synthase [Penicillium chrysogenum]
Length = 474
Score = 190 bits (478), Expect = 2e-47
Identities = 110/323 (34%), Positives = 171/323 (52%), Gaps = 5/323 (1%)
Query: 2 VLDSTLREGEQTPGVNYTPEQRLEIAIALDEVGVDFIEIGHPAVSEDVFRGMKLIAEQGL 61
+++STLREGEQ + +++EIA ALD+ GVD+IE+ P SE + I + GL
Sbjct: 69 IIESTLREGEQFANAFFDTAKKIEIAKALDDFGVDYIELTSPCASEQSRADCEAICKLGL 128
Query: 62 NVELLAHSRALIEDIDYVLKTGVDWVGIFFCLSEACLRKRFRITLDHALEKISRAIEYAK 121
++L H R ++D ++TGVD V + S + + IE+ K
Sbjct: 129 KAKILTHIRCHMDDARIAVETGVDGVDVVIGTSSYLREHSHGKDMTYIKNAAIEVIEFVK 188
Query: 122 DHGLKVRFTPEDTTRTEWANLKRAIRLAKELKVDRISVADTTGSTHPLRFYTLVKKIVN- 180
G+++RF+ ED+ R++ +L ++ V+R+ +ADT G P + Y LV+ +
Sbjct: 189 SKGIEIRFSSEDSFRSDLVDLLSIYSAVDKVGVNRVGIADTVGCASPRQVYELVRVLRGV 248
Query: 181 FGIPVNVHCHNDLGLALANAIMGIEAGATLVDATVNGLGERAGIVDLAQIIT---VLYYH 237
G + H HND G A+ANA +EAGAT +D +V G+GER GI L ++ V
Sbjct: 249 VGCDIETHFHNDTGCAIANAFCALEAGATHIDTSVLGIGERNGITPLGGLMARMMVADRE 308
Query: 238 YGIKKYRLDLLYRVSNLVSEITGISPQPNYPIVGENAFTHKAGLHVSAVLKDPRFYEFLP 297
Y KY+L+ L + +LV+E ++ N I G AFTHKAG+H A+L +P YE +
Sbjct: 309 YVKSKYKLEKLKEIEDLVAEAVEVNIPFNNYITGFCAFTHKAGIHAKAILNNPSTYEIIN 368
Query: 298 AEVFGRERTI-YVDRYAGKDTIR 319
FG R + + R G + I+
Sbjct: 369 PADFGMSRYVHFASRLTGWNAIK 391
>gi|10954458 2-isopropylmalate synthase [Buchnera aphidicola]
>gi|3282740|gb|AAD12600.1| (AF041837) 2-isopropylmalate
synthase [Buchnera aphidicola]
Length = 516
Score = 188 bits (472), Expect = 1e-46
Identities = 111/348 (31%), Positives = 191/348 (53%), Gaps = 24/348 (6%)
Query: 1 MVLDSTLREGEQTPGVNYTPEQRLEIAIALDEVGVDFIEIGHPAVSEDVFRGMKLIAEQG 60
++ D+TLR+GEQ + + +++L+IA++L++ G+D IE+G P S F+ ++ I+++
Sbjct: 6 IIFDTTLRDGEQALQASLSVKEKLQIALSLEKCGIDIIEVGFPISSPGDFKSVQTISKKI 65
Query: 61 LNVELLAHSRALIEDI----DYVLKTGVDWVGIFFCLS----EACLRKRFRITLDHALEK 112
N + + +R + +DI D + + + IF S E+ LRK F +D A+
Sbjct: 66 KNSRICSLARCVEKDIEVAGDAMSSSDFFRIHIFLATSTLHMESKLRKNFDEIIDMAVSS 125
Query: 113 ISRAIEYAKDHGLKVRFTPEDTTRTEWANLKRAIRLAKELKVDRISVADTTGSTHPLRFY 172
+ +A+ Y D V F+ ED +RT NL R + + V I++ DT G T P
Sbjct: 126 VKKALRYTDD----VEFSCEDASRTTMDNLCRIVEKLIKAGVKTINIPDTVGYTIPNELS 181
Query: 173 TLVKKIVNFGIP------VNVHCHNDLGLALANAIMGIEAGATLVDATVNGLGERAGIVD 226
++K + +P ++VHCHNDLG+A+ N+I I+AGA ++ T+NG+GERAG
Sbjct: 182 NIIKNLFE-RVPNIHKSIISVHCHNDLGMAVGNSISAIQAGARQIEGTINGIGERAGNTA 240
Query: 227 LAQIITVLYYHYGIKKYRLDL----LYRVSNLVSEITGISPQPNYPIVGENAFTHKAGLH 282
L +II + I ++ +YR S ++S+I + N IVG NAF H +G+H
Sbjct: 241 LEEIIMAIKVREDILGVSTNIVHKEIYRTSQIISQICNMPIPANKAIVGSNAFAHSSGIH 300
Query: 283 VSAVLKDPRFYEFLPAEVFG-RERTIYVDRYAGKDTIRYYLEKFGIRD 329
VLK+ + YE + G +E + + +G+ ++YY++K G +D
Sbjct: 301 QDGVLKNRKNYEIMEPNTIGVKEVKLNLTSRSGRAAVKYYMDKMGYKD 348
>sp|P48571|LEU1_BUCRP 2-ISOPROPYLMALATE SYNTHASE (ALPHA-ISOPROPYLMALATE SYNTHASE)
(ALPHA-IPM SYNTHETASE) >gi|899388|emb|CAA50615.1|
(X71612) 2-isopropylmalate synthase [Buchnera
aphidicola]
Length = 518
Score = 187 bits (470), Expect = 2e-46
Identities = 110/348 (31%), Positives = 190/348 (53%), Gaps = 24/348 (6%)
Query: 1 MVLDSTLREGEQTPGVNYTPEQRLEIAIALDEVGVDFIEIGHPAVSEDVFRGMKLIAEQG 60
++ D+TLR+GEQ + + +Q+L+IA++L+ G+D IE+G P S F+ ++ I++
Sbjct: 6 IIFDTTLRDGEQALQASLSVKQKLQIALSLENTGIDIIEVGFPISSPGDFKSVQTISKNI 65
Query: 61 LNVELLAHSRALIEDIDYVLK----TGVDWVGIFFCLS----EACLRKRFRITLDHALEK 112
N + + +R L +DID + + + IF S E+ L+K F +D A+
Sbjct: 66 KNSRICSLARCLDKDIDAAAEAMHSSNAFRIHIFLATSILHMESKLKKNFDQIIDMAITS 125
Query: 113 ISRAIEYAKDHGLKVRFTPEDTTRTEWANLKRAIRLAKELKVDRISVADTTGSTHPLRFY 172
+ RA+ Y D V F+ ED +RT NL R + V I++ DT G T P
Sbjct: 126 VKRALRYTDD----VEFSCEDASRTTMDNLCRIVEKLINAGVKTINIPDTVGYTVPNELS 181
Query: 173 TLVKKIVNFGIP------VNVHCHNDLGLALANAIMGIEAGATLVDATVNGLGERAGIVD 226
+++ + +P ++VHCHNDLG+A+ N+I I+AGA ++ T+NG+GERAG
Sbjct: 182 SIIHNLFQ-RVPNIDKSIISVHCHNDLGMAVGNSISAIQAGARQIEGTINGIGERAGNTA 240
Query: 227 LAQIITVLYYHYGI----KKYRLDLLYRVSNLVSEITGISPQPNYPIVGENAFTHKAGLH 282
L ++I + + K + +YR S ++S+I + PN IVG NAF H +G+H
Sbjct: 241 LEEVIIAIKVREDVLGVSTKIKHKEIYRTSQIISQICNLPIPPNKAIVGSNAFAHSSGIH 300
Query: 283 VSAVLKDPRFYEFL-PAEVFGRERTIYVDRYAGKDTIRYYLEKFGIRD 329
VLK+ + YE + P+ + +E + + +G+ +++Y+ + G R+
Sbjct: 301 QDGVLKNRKNYEIMEPSSIGLKEVKLNLTSRSGRAAVKHYMTEMGYRE 348
>sp|O67862|LEU1_AQUAE 2-ISOPROPYLMALATE SYNTHASE (ALPHA-ISOPROPYLMALATE SYNTHASE)
(ALPHA-IPM SYNTHETASE) >gi|7447051|pir||B70479
2-isopropylmalate synthase (EC 4.1.3.12) - Aquifex
aeolicus >gi|2984301|gb|AAC07824.1| (AE000772)
2-isopropylmalate synthase [Aquifex aeolicus]
Length = 524
Score = 185 bits (465), Expect = 7e-46
Identities = 118/346 (34%), Positives = 187/346 (53%), Gaps = 23/346 (6%)
Query: 2 VLDSTLREGEQTPGVNYTPEQRLEIAIALDEVGVDFIEIGHPAVSEDVFRGMKLIAEQGL 61
+ D+TLR+GEQ PG + T E++L++A L ++ VD IE G A S+ F + IA++
Sbjct: 11 IFDTTLRDGEQAPGFSMTTEEKLQMAHQLAKLNVDIIEAGFAAASKGDFEAVNRIAKEVK 70
Query: 62 NVELLAHSRALIEDIDYVLKT----GVDWVGIFFCLSEACLRKRFRITLDHALEKISRAI 117
+ + +RAL DI+ K + F S + + R+T D LE+I +A+
Sbjct: 71 GPVICSLARALESDIEIAAKALEPAERKRIHTFIATSPIHMEYKLRMTPDQVLERIKKAV 130
Query: 118 EYAKDHGLKVRFTPEDTTRTEWANLKRAIRLAKELKVDRISVADTTGSTHPLRFYTLVKK 177
+A++ V F+ ED TR+E L RAI A + I++ DT G P F L++
Sbjct: 131 SFARNFTDDVEFSCEDATRSEREFLYRAIETAIKHGATVINIPDTVGYAIPEEFGQLIED 190
Query: 178 IVNFGIP------VNVHCHNDLGLALANAIMGIEAGATLVDATVNGLGERAGIVDLAQII 231
I+N +P ++VHCH+DLGLA AN++ ++ GA V+ T+NG+GERAG L +++
Sbjct: 191 IMN-NVPNIDKVILSVHCHDDLGLATANSLTAVKHGARQVECTINGIGERAGNAALEEVV 249
Query: 232 TVLYYHYGIKKYRLDL--------LYRVSNLVSEITGISPQPNYPIVGENAFTHKAGLHV 283
L K + DL +Y+ S L+ ITG QPN IVG+NAF H++G+H
Sbjct: 250 MALKVR---KDFFGDLYTDVNTKEIYKTSRLLCRITGNFVQPNKAIVGDNAFAHESGIHQ 306
Query: 284 SAVLKDPRFYEFL-PAEVFGRERTIYVDRYAGKDTIRYYLEKFGIR 328
VL YE + P +V I + +++G+ ++ LE+ G +
Sbjct: 307 HGVLSHRMTYEIMNPEDVGFPMSRIVLGKHSGRHALKRRLEELGFK 352
>sp|Q02141|LEU1_LACLA 2-ISOPROPYLMALATE SYNTHASE (ALPHA-ISOPROPYLMALATE SYNTHASE)
(ALPHA-IPM SYNTHETASE) >gi|486724|pir||S35132
2-isopropylmalate synthase (EC 4.1.3.12) - Lactococcus
lactis subsp. lactis
Length = 513
Score = 181 bits (455), Expect = 1e-44
Identities = 108/338 (31%), Positives = 186/338 (54%), Gaps = 14/338 (4%)
Query: 4 DSTLREGEQTPGVNYTPEQRLEIAIALDEVGVDFIEIGHPAVSEDVFRGMKLIAEQGLNV 63
D++LR+GEQTPGV+++ +++ IA L++ + IE G A S D F +K IA+ +
Sbjct: 8 DTSLRDGEQTPGVSFSISEKVTIAKQLEKWRISVIEAGFSAASPDSFEAVKQIADSLNDT 67
Query: 64 ELLAHSRALIEDIDYVLKT--GVDW--VGIFFCLSEACLRKRFRITLDHALEKISRAIEY 119
+ A +R +I DID ++ G + + +F S ++ + +I+ + L+ I + + Y
Sbjct: 68 AVTALARCVISDIDKAVEAVKGAKYPQIHVFIATSPIHMKYKLKISPEEVLKNIDKCVRY 127
Query: 120 AKDHGLKVRFTPEDTTRTEWANLKRAIRLAKELKVDRISVADTTGSTHPLRFYTLVKKIV 179
A++ V F+PED TRTE L A++ A + I++ DT G T P + + K ++
Sbjct: 128 ARERVEVVEFSPEDATRTELNFLLEAVQTAVDAGATYINIPDTVGYTTPEEYGKIFKFLI 187
Query: 180 NFG-----IPVNVHCHNDLGLALANAIMGIEAGATLVDATVNGLGERAGIVDLAQIITVL 234
+ I + HCH+DLG+A+AN++ I+AGA V+ TVNG+GERAG L +I L
Sbjct: 188 DNTKSDREIIFSPHCHDDLGMAVANSLAAIKAGAGRVEGTVNGIGERAGNAALEEIAVAL 247
Query: 235 Y----YHYGIKKYRLDLLYRVSNLVSEITGISPQPNYPIVGENAFTHKAGLHVSAVLKDP 290
+ ++ +L + L+S+ +GI+ N IVG NAF H++G+H VLK+
Sbjct: 248 HIRKDFYQAQSPLKLSETAATAELISQFSGIAIPKNKAIVGANAFAHESGIHQDGVLKNA 307
Query: 291 RFYEFLPAEVFG-RERTIYVDRYAGKDTIRYYLEKFGI 327
YE + E+ G + ++ + + +G+ L + I
Sbjct: 308 ETYEIITPELVGIKHNSLPLGKLSGRHAFSEKLTELNI 345
>gb|AAB81913.1| (U92974) LeuA [Lactococcus lactis]
Length = 565
Score = 181 bits (455), Expect = 1e-44
Identities = 108/338 (31%), Positives = 186/338 (54%), Gaps = 14/338 (4%)
Query: 4 DSTLREGEQTPGVNYTPEQRLEIAIALDEVGVDFIEIGHPAVSEDVFRGMKLIAEQGLNV 63
D++LR+GEQTPGV+++ +++ IA L++ + IE G A S D F +K IA+ +
Sbjct: 60 DTSLRDGEQTPGVSFSISEKVTIAKQLEKWRISVIEAGFSAASPDSFEAVKQIADSLNDT 119
Query: 64 ELLAHSRALIEDIDYVLKT--GVDW--VGIFFCLSEACLRKRFRITLDHALEKISRAIEY 119
+ A +R +I DID ++ G + + +F S ++ + +I+ + L+ I + + Y
Sbjct: 120 AVTALARCVISDIDKAVEAVKGAKYPQIHVFIATSPIHMKYKLKISPEEVLKNIDKCVRY 179
Query: 120 AKDHGLKVRFTPEDTTRTEWANLKRAIRLAKELKVDRISVADTTGSTHPLRFYTLVKKIV 179
A++ V F+PED TRTE L A++ A + I++ DT G T P + + K ++
Sbjct: 180 ARERVEVVEFSPEDATRTELNFLLEAVQTAVDAGATYINIPDTVGYTTPEEYGKIFKFLI 239
Query: 180 NFG-----IPVNVHCHNDLGLALANAIMGIEAGATLVDATVNGLGERAGIVDLAQIITVL 234
+ I + HCH+DLG+A+AN++ I+AGA V+ TVNG+GERAG L +I L
Sbjct: 240 DNTKSDREIIFSPHCHDDLGMAVANSLAAIKAGAGRVEGTVNGIGERAGNAALEEIAVAL 299
Query: 235 Y----YHYGIKKYRLDLLYRVSNLVSEITGISPQPNYPIVGENAFTHKAGLHVSAVLKDP 290
+ ++ +L + L+S+ +GI+ N IVG NAF H++G+H VLK+
Sbjct: 300 HIRKDFYQAQSPLKLSETAATAELISQFSGIAIPKNKAIVGANAFAHESGIHQDGVLKNA 359
Query: 291 RFYEFLPAEVFG-RERTIYVDRYAGKDTIRYYLEKFGI 327
YE + E+ G + ++ + + +G+ L + I
Sbjct: 360 ETYEIITPELVGIKHNSLPLGKLSGRHAFSEKLTELNI 397
>emb|CAA07305.2| (AJ006878) 2-isoproylmalate synthase [Buchnera aphidicola]
Length = 519
Score = 180 bits (453), Expect = 2e-44
Identities = 107/345 (31%), Positives = 191/345 (55%), Gaps = 24/345 (6%)
Query: 1 MVLDSTLREGEQTPGVNYTPEQRLEIAIALDEVGVDFIEIGHPAVSEDVFRGMKLIAEQG 60
++ D+TLR+GEQ + + +++L+IA++L++ G+D +EIG P S F+ ++ I++
Sbjct: 6 VIFDTTLRDGEQALQASLSVKEKLQIALSLEKCGIDILEIGFPVSSPGDFKSVQTISKNI 65
Query: 61 LNVELLAHSRALIEDIDY----VLKTGVDWVGIFFCLS----EACLRKRFRITLDHALEK 112
N + + +R + +DID + + + IF S E+ L+K F +D A+
Sbjct: 66 KNSRICSLARCIEKDIDAAGEAMSSSDSFRIHIFLATSTLHMESKLKKNFNEIIDMAVFS 125
Query: 113 ISRAIEYAKDHGLKVRFTPEDTTRTEWANLKRAIRLAKELKVDRISVADTTGSTHPLRFY 172
+ +A+ Y D + F+ ED TRT NL R + + V I++ DT G T P
Sbjct: 126 VKKALRYTDD----IEFSCEDATRTTMDNLCRIVETLIKSGVKTINIPDTVGYTVPNELS 181
Query: 173 TLVKKIVNFGIP------VNVHCHNDLGLALANAIMGIEAGATLVDATVNGLGERAGIVD 226
++K ++ +P ++VHCH+DLG+A+ N+I I+AGA ++ T+NG+GERAG
Sbjct: 182 CIIKNLLE-RVPNIHKSIISVHCHDDLGMAVGNSISAIQAGARQIEGTINGIGERAGNTA 240
Query: 227 LAQIITVLYYHYGIKKYRLDL----LYRVSNLVSEITGISPQPNYPIVGENAFTHKAGLH 282
L +II + I ++ +YR S +VS+I + N IVG NAF H +G+H
Sbjct: 241 LEEIIMAIKVREDILSVSTNINYKEIYRTSKIVSQICNMPIPSNKAIVGSNAFAHSSGIH 300
Query: 283 VSAVLKDPRFYEFL-PAEVFGRERTIYVDRYAGKDTIRYYLEKFG 326
VLK+ + YE + P+ + +E + + +G+ +++Y+++ G
Sbjct: 301 QDGVLKNRKNYEIMEPSSIGLKEVKLNLTSRSGRAAVKHYMDEMG 345
>gi|10957107 2-isopropylmalate synthase [Buchnera sp. APS]
>gi|11182435|sp|Q9ZEY8|LEU1_BUCAI 2-ISOPROPYLMALATE
SYNTHASE (ALPHA-ISOPROPYLMALATE SYNTHASE) (ALPHA-IPM
SYNTHETASE) >gi|7707821|dbj|BAA95423.1| (AP001071)
2-isopropylmalate synthase [Buchnera sp. APS]
Length = 519
Score = 180 bits (451), Expect = 3e-44
Identities = 107/345 (31%), Positives = 190/345 (55%), Gaps = 24/345 (6%)
Query: 1 MVLDSTLREGEQTPGVNYTPEQRLEIAIALDEVGVDFIEIGHPAVSEDVFRGMKLIAEQG 60
++ D+TLR+GEQ + + +++L+IA++L++ G+D +EIG P S F+ ++ I++
Sbjct: 6 VIFDTTLRDGEQALQASLSVKEKLQIALSLEKCGIDILEIGFPVSSPGDFKSVQTISKNI 65
Query: 61 LNVELLAHSRALIEDIDY----VLKTGVDWVGIFFCLS----EACLRKRFRITLDHALEK 112
N + + +R + +DID + + + IF S E+ L+K F +D A+
Sbjct: 66 KNSRICSLARCIEKDIDAAGEAMSSSDSFRIHIFLATSTLHMESKLKKNFNEIIDMAVFS 125
Query: 113 ISRAIEYAKDHGLKVRFTPEDTTRTEWANLKRAIRLAKELKVDRISVADTTGSTHPLRFY 172
+ +A+ Y D + F+ ED TRT NL R + + V I++ DT G T P
Sbjct: 126 VKKALRYTDD----IEFSCEDATRTTMDNLCRIVETLIKSGVKTINIPDTVGYTVPNELS 181
Query: 173 TLVKKIVNFGIP------VNVHCHNDLGLALANAIMGIEAGATLVDATVNGLGERAGIVD 226
++K + +P ++VHCH+DLG+A+ N+I I+AGA ++ T+NG+GERAG
Sbjct: 182 CIIKNLFE-RVPNIHKSIISVHCHDDLGMAVGNSISAIQAGARQIEGTINGIGERAGNTA 240
Query: 227 LAQIITVLYYHYGIKKYRLDL----LYRVSNLVSEITGISPQPNYPIVGENAFTHKAGLH 282
L +II + I ++ +YR S +VS+I + N IVG NAF H +G+H
Sbjct: 241 LEEIIMAIKVREDILSVSTNINYKEIYRTSKIVSQICNMPIPSNKAIVGSNAFAHSSGIH 300
Query: 283 VSAVLKDPRFYEFL-PAEVFGRERTIYVDRYAGKDTIRYYLEKFG 326
VLK+ + YE + P+ + +E + + +G+ +++Y+++ G
Sbjct: 301 QDGVLKNRKNYEIMEPSSIGLKEVKLNLTSRSGRAAVKHYMDEMG 345
>pir||F82070 2-isopropylmalate synthase VC2490 [imported] - Vibrio cholerae
(group O1 strain N16961) >gi|9657070|gb|AAF95632.1|
(AE004318) 2-isopropylmalate synthase [Vibrio cholerae]
Length = 516
Score = 179 bits (449), Expect = 5e-44
Identities = 111/345 (32%), Positives = 189/345 (54%), Gaps = 16/345 (4%)
Query: 1 MVLDSTLREGEQTPGVNYTPEQRLEIAIALDEVGVDFIEIGHPAVSEDVFRGMKLIAEQG 60
++ D+TLR+GEQ + T +++L+IA AL+ +GVD IE G P S F ++ IA+
Sbjct: 6 IIFDTTLRDGEQALSASLTVKEKLQIAYALERLGVDIIEAGFPVSSPGDFESVQTIAKNI 65
Query: 61 LNVELLAHSRALIEDID---YVLKTGVDW-VGIFFCLSEACLRKRFRITLDHALEKISRA 116
N + A SRA+ +DID LK + + F S ++ + R + D + +A
Sbjct: 66 KNSRVCALSRAVAKDIDAAAEALKVAEAFRIHTFISTSTIHVQDKLRRSYDDVVAMAVKA 125
Query: 117 IEYAKDHGLKVRFTPEDTTRTEWANLKRAIRLAKELKVDRISVADTTGSTHPLRFYTLVK 176
+++A+ + V F+ ED RT NL R + A I++ DT G T P F +++
Sbjct: 126 VKHARQYTDDVEFSCEDAGRTPIDNLCRMVEAAINAGARTINIPDTVGYTVPSEFGGIIQ 185
Query: 177 KIVNFGIP------VNVHCHNDLGLALANAIMGIEAGATLVDATVNGLGERAG---IVDL 227
+ N +P ++VHCH+DLG+++AN+I I+AGA V+ T+NG+GERAG + ++
Sbjct: 186 TLFN-RVPNIDKAIISVHCHDDLGMSVANSIAAIQAGARQVEGTINGIGERAGNCALEEI 244
Query: 228 AQIITVLYYHYGIKK-YRLDLLYRVSNLVSEITGISPQPNYPIVGENAFTHKAGLHVSAV 286
A II G+ + D + R S LVS++ + Q N IVG NAF+H +G+H +
Sbjct: 245 AMIIKTRQELLGVTTGIKHDEISRTSKLVSQLCNMPIQSNKAIVGANAFSHSSGIHQDGM 304
Query: 287 LKDPRFYEFLPAEVFG-RERTIYVDRYAGKDTIRYYLEKFGIRDH 330
LK+ YE + E G + + + + +G+ ++ +++ G ++
Sbjct: 305 LKNKNTYEIMTPESIGLKNQALNLTSRSGRAAVKSHMDSMGYNEN 349
>pir||E75045 2-isopropylmalate synthase (leua-3) PAB0894 - Pyrococcus abyssi
(strain Orsay) >gi|5458771|emb|CAB50258.1| (AJ248287)
2-isopropylmalate synthase (leuA-3) [Pyrococcus abyssi]
Length = 526
Score = 178 bits (447), Expect = 9e-44
Identities = 111/340 (32%), Positives = 183/340 (53%), Gaps = 16/340 (4%)
Query: 4 DSTLREGEQTPGVNYTPEQRLEIAIALDEVGVDFIEIGHPAVSEDVFRGMKLIAEQGL-N 62
D+TLR+G Q G++++ E +L+I LDE G+ +IE G P + + K + + L N
Sbjct: 11 DTTLRDGSQMEGISFSLEDKLKITEKLDEFGIHYIEGGWPGSNPKDIQYFKAVRDLPLEN 70
Query: 63 VELLAHS-----RALIED---IDYVLKTGVDWVGIFFCLSEACLRKRFRITLDHALEKIS 114
++ A R E+ ++ ++++ IF + + + R TL++ ++ I
Sbjct: 71 AKIAAFGSTRRPRLRPEEDPNLNALVESEAPIATIFGKSWDLHVTEALRTTLENNIQMII 130
Query: 115 RAIEYAKDHGLKVRFTPE---DTTRTEWANLKRAIRLAKELKVDRISVADTTGSTHPLRF 171
+IEY +DHG+ V + E D R + I+ A+E +RI +ADT G + P
Sbjct: 131 DSIEYLRDHGMVVFYDAEHFFDGYRENPEYAMKTIKAAEEAGAERIVLADTNGGSLPSFI 190
Query: 172 YTLVKKIVN-FGIPVNVHCHNDLGLALANAIMGIEAGATLVDATVNGLGERAGIVDLAQI 230
+V+K+ P+ +H HND LA+AN+++ EAG + T+NG GER G +L I
Sbjct: 191 KEVVEKVKEEVKTPLGIHAHNDSELAVANSLIAFEAGVVQIQGTINGYGERCGNANLISI 250
Query: 231 ITVLYYHYGIK---KYRLDLLYRVSNLVSEITGISPQPNYPIVGENAFTHKAGLHVSAVL 287
I L YG++ K RL L +++ V+E+ + N P VG++AF HK G+HVSAVL
Sbjct: 251 IPALELKYGVEVVGKERLRKLKELAHFVAELANMEIPRNQPYVGDSAFAHKGGVHVSAVL 310
Query: 288 KDPRFYEFLPAEVFGRERTIYVDRYAGKDTIRYYLEKFGI 327
K+PR YE + E+ G R + V +G+ + Y ++ GI
Sbjct: 311 KNPRTYEHIDPELVGNRRKVVVSELSGRSNLIYKAKELGI 350
>pir||C81270 2-isopropylmalate synthase (EC 4.1.3.12) Cj1719c [imported] -
Campylobacter jejuni (strain NCTC 11168)
>gi|6969134|emb|CAB73705.1| (AL139079) 2-isopropylmalate
synthase [Campylobacter jejuni]
Length = 511
Score = 175 bits (440), Expect = 6e-43
Identities = 115/342 (33%), Positives = 178/342 (51%), Gaps = 17/342 (4%)
Query: 1 MVLDSTLREGEQTPGVNYTPEQRLEIAIALDEVGVDFIEIGHPAVSEDVFRGMKLIAEQG 60
++ D+TLR+GEQ G + Q+L+IA+AL+ +GVD IE G P S+ F+ ++ IA +
Sbjct: 7 IIFDTTLRDGEQALGSSLGINQKLQIALALENLGVDVIEAGFPVSSQGDFKAVQKIASKV 66
Query: 61 LNVELLAHSRALIEDIDY---VLKTGVDW-VGIFFCLSEACLRKRFRITLDHALEKISRA 116
N + A SRAL +DID LK + + F S ++ + + D L RA
Sbjct: 67 KNSTICALSRALDKDIDMAYEALKVAKHFRIHTFIATSTLHMQDKLKKDFDEILSMAKRA 126
Query: 117 IEYAKDHGLKVRFTPEDTTRTEWANLKRAIRLAKELKVDRISVADTTGSTHPLRFYTLVK 176
I A+ + V F+ ED RT NL + A + I++ DT G T P F ++K
Sbjct: 127 IIRARSYTDDVEFSCEDAGRTPIDNLCFMVENAIKAGAKTINIPDTVGYTLPSEFANIIK 186
Query: 177 KIVNFGIP------VNVHCHNDLGLALANAIMGIEAGATLVDATVNGLGERAGIVDLAQI 230
+ N +P ++VHCHNDLG+A N++ I GA ++ T+NGLGERAG L ++
Sbjct: 187 ILFN-KVPNIDKAIISVHCHNDLGMATGNSLSAILQGARQIECTINGLGERAGNCALEEV 245
Query: 231 ITVL-----YYHYGIKKYRLDLLYRVSNLVSEITGISPQPNYPIVGENAFTHKAGLHVSA 285
+ + Y + + +++ S LVS IT S + IVG NAF+H +G+H
Sbjct: 246 VMAIKTRKDYLKGFYTDIKCENIFKTSKLVSAITNESIPSHKAIVGSNAFSHSSGIHQDG 305
Query: 286 VLKDPRFYEFLPAEVFG-RERTIYVDRYAGKDTIRYYLEKFG 326
VLK+ + YE + G E + + +G+ I+ LE G
Sbjct: 306 VLKNRQTYEIISPSAIGIHENRMLMTARSGRAMIKTCLENLG 347
>dbj|BAB06777.1| (AP001517) 2-isopropylmalate synthase [Bacillus halodurans]
Length = 515
Score = 175 bits (440), Expect = 6e-43
Identities = 110/339 (32%), Positives = 190/339 (55%), Gaps = 14/339 (4%)
Query: 2 VLDSTLREGEQTPGVNYTPEQRLEIAIALDEVGVDFIEIGHPAVSEDVFRGMKLIAEQGL 61
V D+TLR+GEQ+ GVN E+++EIA L+ +GVD IE G PA S+ F+ +K IAE
Sbjct: 6 VFDTTLRDGEQSAGVNLNFEEKMEIAKQLERLGVDIIEAGFPASSQGDFQSVKAIAETVK 65
Query: 62 NVELLAHSRALIEDID---YVLKTGVD-WVGIFFCLSEACLRKRFRITLDHALEKISRAI 117
+ +R++ +DID LK+ + + +F S + + R+T + +EK ++
Sbjct: 66 GSSVTGLARSVQKDIDAAWEALKSAEEPRIHLFIATSPIHMEHKLRMTPEQVIEKAVESV 125
Query: 118 EYAKDHGLKVRFTPEDTTRTEWANLKRAIRLAKELKVDRISVADTTGSTHP---LRFYTL 174
+YA V+++ ED +R+++ L + I + I++ DT G T P R +
Sbjct: 126 KYAASRFKHVQWSAEDASRSDFPFLAQIIEAVIQAGATVINLPDTVGYTTPQEIKRMFQY 185
Query: 175 VKKIVNF--GIPVNVHCHNDLGLALANAIMGIEAGATLVDATVNGLGERAGIVDLAQIIT 232
+K+ V + ++ H H+DLG+A+AN++ I+ GA V+ T+NG+GERAG L +I
Sbjct: 186 MKQNVPSIDKVSLSTHNHDDLGMAVANSLAAIQGGADQVECTINGIGERAGNASLEEIAV 245
Query: 233 VLYY---HYGIKK-YRLDLLYRVSNLVSEITGISPQPNYPIVGENAFTHKAGLHVSAVLK 288
L HY + L + R S+LVS++TG+ N +VG NAF H++G+H VLK
Sbjct: 246 ALNIRKDHYETETGLILKEIKRTSSLVSKLTGMVVPNNKAVVGANAFAHESGIHQDGVLK 305
Query: 289 DPRFYEFLPAEVFG-RERTIYVDRYAGKDTIRYYLEKFG 326
+ + YE + E+ G ++ + +++G+ + +++ G
Sbjct: 306 NKQTYEIITPEMVGVSSNSMVLGKHSGRHAFKTKVQELG 344
>pir||E64106 2-isopropylmalate synthase (EC 4.1.3.12) - Haemophilus influenzae
(strain Rd KW20) >gi|1574015|gb|AAC22647.1| (U32779)
2-isopropylmalate synthase (leuA) [Haemophilus
influenzae Rd]
Length = 531
Score = 173 bits (435), Expect = 2e-42
Identities = 108/348 (31%), Positives = 185/348 (53%), Gaps = 24/348 (6%)
Query: 1 MVLDSTLREGEQTPGVNYTPEQRLEIAIALDEVGVDFIEIGHPAVSEDVFRGMKLIAEQG 60
++ D+TLR+GEQ + T +++L+IA+AL+ +GVD +E+G P S+ F ++ IA
Sbjct: 22 IIFDTTLRDGEQALKASLTVKEKLQIALALERLGVDVMEVGFPVSSQGDFESVQTIARHI 81
Query: 61 LNVELLAHSRALIEDID---YVLKTGVDW-VGIFFCLS----EACLRKRFRITLDHALEK 112
N + A SRA+ +DID LK + + F S EA L++ F + A+
Sbjct: 82 KNARVAALSRAVDKDIDAAYEALKVAEAFRIHTFIASSALHVEAKLKRSFDDVVGMAVAA 141
Query: 113 ISRAIEYAKDHGLKVRFTPEDTTRTEWANLKRAIRLAKELKVDRISVADTTGSTHPLRFY 172
+ RA Y D V F+ ED RT N+ R + A +++ DT G P +
Sbjct: 142 VKRARNYTDD----VEFSCEDAGRTGIDNICRIVEAAINAGATTVNIPDTVGFCLPNEYG 197
Query: 173 TLVKKIVNFGIP------VNVHCHNDLGLALANAIMGIEAGATLVDATVNGLGERAGIVD 226
++ ++ N +P ++VHCHNDLG+A AN++ ++ GA ++ T+NG+GERAG
Sbjct: 198 NIIAQVRNC-VPNIDKAVISVHCHNDLGMATANSLTAVQNGARQIECTINGIGERAGNTS 256
Query: 227 LAQIITVLYYH---YGIKKY-RLDLLYRVSNLVSEITGISPQPNYPIVGENAFTHKAGLH 282
L +++ + G+ + ++RVS +VS++ + QPN IVG NAF H +G+H
Sbjct: 257 LEEVVMAMKVRQDFMGVDTHINTQEIHRVSQMVSQLCNMPIQPNKAIVGSNAFAHSSGIH 316
Query: 283 VSAVLKDPRFYEFLPAEVFG-RERTIYVDRYAGKDTIRYYLEKFGIRD 329
+LK+ YE L E G ++ + + +G+ ++ ++ G +
Sbjct: 317 QDGMLKNKNTYEILSPETIGLKKEKLNLTARSGRAAVKGHMADMGYNE 364
>sp|P43861|LEU1_HAEIN 2-ISOPROPYLMALATE SYNTHASE (ALPHA-ISOPROPYLMALATE SYNTHASE)
(ALPHA-IPM SYNTHETASE)
Length = 515
Score = 173 bits (435), Expect = 2e-42
Identities = 108/348 (31%), Positives = 185/348 (53%), Gaps = 24/348 (6%)
Query: 1 MVLDSTLREGEQTPGVNYTPEQRLEIAIALDEVGVDFIEIGHPAVSEDVFRGMKLIAEQG 60
++ D+TLR+GEQ + T +++L+IA+AL+ +GVD +E+G P S+ F ++ IA
Sbjct: 6 IIFDTTLRDGEQALKASLTVKEKLQIALALERLGVDVMEVGFPVSSQGDFESVQTIARHI 65
Query: 61 LNVELLAHSRALIEDID---YVLKTGVDW-VGIFFCLS----EACLRKRFRITLDHALEK 112
N + A SRA+ +DID LK + + F S EA L++ F + A+
Sbjct: 66 KNARVAALSRAVDKDIDAAYEALKVAEAFRIHTFIASSALHVEAKLKRSFDDVVGMAVAA 125
Query: 113 ISRAIEYAKDHGLKVRFTPEDTTRTEWANLKRAIRLAKELKVDRISVADTTGSTHPLRFY 172
+ RA Y D V F+ ED RT N+ R + A +++ DT G P +
Sbjct: 126 VKRARNYTDD----VEFSCEDAGRTGIDNICRIVEAAINAGATTVNIPDTVGFCLPNEYG 181
Query: 173 TLVKKIVNFGIP------VNVHCHNDLGLALANAIMGIEAGATLVDATVNGLGERAGIVD 226
++ ++ N +P ++VHCHNDLG+A AN++ ++ GA ++ T+NG+GERAG
Sbjct: 182 NIIAQVRNC-VPNIDKAVISVHCHNDLGMATANSLTAVQNGARQIECTINGIGERAGNTS 240
Query: 227 LAQIITVLYYH---YGIKKY-RLDLLYRVSNLVSEITGISPQPNYPIVGENAFTHKAGLH 282
L +++ + G+ + ++RVS +VS++ + QPN IVG NAF H +G+H
Sbjct: 241 LEEVVMAMKVRQDFMGVDTHINTQEIHRVSQMVSQLCNMPIQPNKAIVGSNAFAHSSGIH 300
Query: 283 VSAVLKDPRFYEFLPAEVFG-RERTIYVDRYAGKDTIRYYLEKFGIRD 329
+LK+ YE L E G ++ + + +G+ ++ ++ G +
Sbjct: 301 QDGMLKNKNTYEILSPETIGLKKEKLNLTARSGRAAVKGHMADMGYNE 348
>sp|P94565|LEU1_BACSU 2-ISOPROPYLMALATE SYNTHASE (ALPHA-ISOPROPYLMALATE SYNTHASE)
(ALPHA-IPM SYNTHETASE) >gi|7447054|pir||H69649
2-isopropylmalate synthase (EC 4.1.3.12) - Bacillus
subtilis >gi|1770069|emb|CAA99531.1| (Z75208)
2-isopropylmalate synthase [Bacillus subtilis]
>gi|2635293|emb|CAB14788.1| (Z99118) 2-isopropylmalate
synthase [Bacillus subtilis]
Length = 518
Score = 172 bits (431), Expect = 6e-42
Identities = 107/340 (31%), Positives = 180/340 (52%), Gaps = 16/340 (4%)
Query: 4 DSTLREGEQTPGVNYTPEQRLEIAIALDEVGVDFIEIGHPAVSEDVFRGMKLIAEQGLNV 63
D+TLR+GEQ+PGVN +++L IA L+ +G D IE G PA S F ++ IA N
Sbjct: 8 DTTLRDGEQSPGVNLNTQEKLAIAKQLERLGADIIEAGFPASSRGDFLAVQEIARTIKNC 67
Query: 64 ELLAHSRALIEDID---YVLKTGVD-WVGIFFCLSEACLRKRFRITLDHALEKISRAIEY 119
+ +R + DID LK G + +F S+ L+ + ++T + +E+ ++Y
Sbjct: 68 SVTGLARCVKGDIDAAWEALKDGAQPRIHVFIATSDIHLKHKLKMTREQVIERAVGMVKY 127
Query: 120 AKDHGLKVRFTPEDTTRTEWANLKRAIRLAKELKVDRISVADTTGSTHPLRFYTLVKKIV 179
AK+ V+++ ED RTE L + + I++ DT G P Y + K +
Sbjct: 128 AKERFPIVQWSAEDACRTELPFLAEIVEKVIDAGASVINLPDTVGYLAPAE-YGNIFKYM 186
Query: 180 NFGIP------VNVHCHNDLGLALANAIMGIEAGATLVDATVNGLGERAGIVDLAQIITV 233
+P ++ HCH+DLG+A+AN++ IE GA ++ VNG+GERAG L +I
Sbjct: 187 KENVPNIHKAKLSAHCHDDLGMAVANSLAAIENGADQIECAVNGIGERAGNAALEEIAVA 246
Query: 234 LY----YHYGIKKYRLDLLYRVSNLVSEITGISPQPNYPIVGENAFTHKAGLHVSAVLKD 289
L+ ++ L+ + R S+LVS++TG++ N +VG+NAF H++G+H LK+
Sbjct: 247 LHTRKDFYQVETGITLNEIKRTSDLVSKLTGMAVPRNKAVVGDNAFAHESGIHQDGFLKE 306
Query: 290 PRFYEFLPAEVFG-RERTIYVDRYAGKDTIRYYLEKFGIR 328
YE + E+ G + + +++G+ + L G +
Sbjct: 307 KSTYEIISPELVGVTADALVLGKHSGRHAFKDRLTALGFQ 346
>gb|AAG27075.1|AF105225_11 (AF105225) NifV [Acetobacter diazotrophicus]
Length = 378
Score = 171 bits (430), Expect = 9e-42
Identities = 111/345 (32%), Positives = 176/345 (50%), Gaps = 4/345 (1%)
Query: 1 MVLDSTLREGEQTPGVNYTPEQRLEIAIALDEVGVDFIEIGHPAVSEDVFRGMKLIAEQG 60
++ D+TLR+GEQ PGV +T ++L IA ALD GVD IE G PA+ + + I ++
Sbjct: 8 LISDTTLRDGEQAPGVAFTAWEKLAIAGALDAAGVDEIEAGVPAMGDAEIAMIAAIGDEV 67
Query: 61 LNVELLAHSRALIEDIDYVLKTGVDWVGIFFCLSEACLRKRFRITLDHALEKISRAIEYA 120
++ R ED+ +TG+ V + S R+ HA +R + A
Sbjct: 68 ERARVIPWCRMRDEDVHAARRTGLGSVHLSVSTSSGRSRRNTACRASHAGHG-ARVVSRA 126
Query: 121 KDHGLKVRFTPEDTTRTEWANLKRAIRLAKELKVDRISVADTTGSTHPLRFYTLVKKIVN 180
+D+GL V ED +R + A L + + E R ADT G P + +++ +
Sbjct: 127 RDYGLAVSVGGEDASRADPAYLVDLLGVIAEAGAFRFRFADTLGVMDPFGVHEVMRYLCQ 186
Query: 181 FG-IPVNVHCHNDLGLALANAIMGIEAGATLVDATVNGLGERAGIVDLAQIITVLYYHYG 239
+ + H H+DLGLA AN + + AGA TV GLGERAG L +++ +Y G
Sbjct: 187 SSPLQLEFHGHDDLGLATANTLAAVRAGAACASVTVLGLGERAGNAPLEEVVAGVYRLLG 246
Query: 240 IKK-YRLDLLYRVSNLVSEITGISPQPNYPIVGENAFTHKAGLHVSAVLKDPRFYEFLPA 298
+LD L ++ LVS P+ IVG+ F H++G+HVS +L+D YE L
Sbjct: 247 RPAGVKLDSLPGLATLVSRAAVRDIPPDKAIVGDAVFRHESGIHVSGLLRDAATYEALDP 306
Query: 299 EVFGRERTIYVDRYAGKDTIRYYLEKFGI-RDHGIVTSLLRKVKS 342
FGR+R I + +++G+ +R+ L G+ D ++ + L V++
Sbjct: 307 VQFGRQREIVLGKHSGRAAVRHALAALGLDADETVIAATLAAVRA 351
>gb|AAG31377.1| (AF197448) 2-isopropylmaltate synthase [Buchnera aphidicola]
Length = 502
Score = 171 bits (429), Expect = 1e-41
Identities = 105/340 (30%), Positives = 181/340 (52%), Gaps = 24/340 (7%)
Query: 9 EGEQTPGVNYTPEQRLEIAIALDEVGVDFIEIGHPAVSEDVFRGMKLIAEQGLNVELLAH 68
+GEQ + + +++L+IA+ L++ GVD +E+G P S F+ ++ I++ N + +
Sbjct: 1 DGEQALQASLSVKEKLQIALCLEKAGVDIMEVGFPISSPGDFKSVQTISQNIKNSRICSL 60
Query: 69 SRALIEDIDYV--LKTGVDWVGIFFCLS------EACLRKRFRITLDHALEKISRAIEYA 120
+R + +DID + D+ I L+ E+ LRK F +D A+ + RA+ Y
Sbjct: 61 ARCIEKDIDTAGEAMSHCDFFRIHVFLATSTLHMESKLRKNFDEIIDMAIFSVKRALRYT 120
Query: 121 KDHGLKVRFTPEDTTRTEWANLKRAIRLAKELKVDRISVADTTGSTHPLRFYTLVKKIVN 180
D V F+ ED +RT NL R + V I++ DT G T P ++K +
Sbjct: 121 DD----VEFSCEDASRTTMDNLCRIVEKLISCGVKTINIPDTVGYTIPNELSLIIKNLFE 176
Query: 181 FGIP------VNVHCHNDLGLALANAIMGIEAGATLVDATVNGLGERAGIVDLAQIITVL 234
+P ++VHCHNDLG+A+ N+I I+AGA ++ T+NG+GERAG L ++I +
Sbjct: 177 -RVPNIHKSTISVHCHNDLGMAVGNSISAIQAGARQIEGTINGIGERAGNTALEEVIMAI 235
Query: 235 YYHYGIKKYRLDL----LYRVSNLVSEITGISPQPNYPIVGENAFTHKAGLHVSAVLKDP 290
I ++ +YR S ++S I + N IVG NAF+H +G+H VLK+
Sbjct: 236 KVREDILGLSTNINHKEIYRTSQVISRICNMPIPSNKAIVGSNAFSHSSGIHQDGVLKNR 295
Query: 291 RFYEFL-PAEVFGRERTIYVDRYAGKDTIRYYLEKFGIRD 329
YE + P+ + ++ + + +G+ ++YY+ + G +D
Sbjct: 296 ENYEIMDPSSIGLKKVKLNLTSRSGRAAVKYYMNEMGYKD 335
>gb|AAG31398.1| (AF197455) 2-isopropylmaltate synthase [Buchnera aphidicola]
Length = 502
Score = 171 bits (429), Expect = 1e-41
Identities = 105/341 (30%), Positives = 183/341 (52%), Gaps = 24/341 (7%)
Query: 9 EGEQTPGVNYTPEQRLEIAIALDEVGVDFIEIGHPAVSEDVFRGMKLIAEQGLNVELLAH 68
+GEQ + + +++L+IA+ L++ GVD +E+G P S F+ ++ I++ N + +
Sbjct: 1 DGEQALQASLSVKEKLQIALCLEKAGVDIMEVGFPISSPGDFKSVQTISQNIKNSRICSL 60
Query: 69 SRALIEDIDYVLK----TGVDWVGIFFCLS----EACLRKRFRITLDHALEKISRAIEYA 120
+R + +DID + + + IF S E+ LRK F +D A+ + RA+ Y
Sbjct: 61 ARCIEKDIDAAGEAMSISNSFRIHIFLATSTLHMESKLRKNFNEIIDMAIFAVKRALRYT 120
Query: 121 KDHGLKVRFTPEDTTRTEWANLKRAIRLAKELKVDRISVADTTGSTHPLRFYTLVKKIVN 180
D + F+ ED +RT NL R + V I++ DT G T P ++K +
Sbjct: 121 DD----IEFSCEDASRTTIDNLCRIVEKLISSGVKTINIPDTVGYTIPNELSNIIKSLFE 176
Query: 181 FGIP------VNVHCHNDLGLALANAIMGIEAGATLVDATVNGLGERAGIVDLAQIITVL 234
+P ++VHCHNDLG+A+ N+I I+AGA ++ T+NG+GERAG L +II +
Sbjct: 177 -RVPNIHKSIISVHCHNDLGMAVGNSISAIQAGARQIEGTINGIGERAGNTALEEIIMAI 235
Query: 235 YYHYGIKKYRLDL----LYRVSNLVSEITGISPQPNYPIVGENAFTHKAGLHVSAVLKDP 290
I ++ +YR S +VS I + N IVG NAF+H +G+H VLK+
Sbjct: 236 KVREDILGLSTNINHKEIYRTSQIVSRICNVPIPSNKAIVGSNAFSHSSGIHQDGVLKNR 295
Query: 291 RFYEFL-PAEVFGRERTIYVDRYAGKDTIRYYLEKFGIRDH 330
YE + P+ + ++ + + +G+ ++YY+++ G +++
Sbjct: 296 ENYEIMDPSSIGLKKVRLNLTSRSGRAAVKYYMKEMGYKEN 336
>gb|AAG31383.1| (AF197450) 2-isopropylmaltate synthase [Buchnera aphidicola]
Length = 502
Score = 170 bits (427), Expect = 2e-41
Identities = 104/340 (30%), Positives = 180/340 (52%), Gaps = 24/340 (7%)
Query: 9 EGEQTPGVNYTPEQRLEIAIALDEVGVDFIEIGHPAVSEDVFRGMKLIAEQGLNVELLAH 68
+GEQ+ + + +++L+IA+ L++ GVD IE+G P S F+ ++ I+++ N ++ +
Sbjct: 1 DGEQSLQASLSVKEKLQIALCLEKAGVDIIEVGFPISSPGDFKSVQTISQKIKNSKICSL 60
Query: 69 SRALIEDIDYVLKT----GVDWVGIFFCLS----EACLRKRFRITLDHALEKISRAIEYA 120
+R + +DID + + IF S E+ LRK F ++ A+ + RA+ Y
Sbjct: 61 ARCIEKDIDTAAEAMSVCNSFRIHIFLATSTLHIESKLRKNFNEIIEMAIFSVKRALRYT 120
Query: 121 KDHGLKVRFTPEDTTRTEWANLKRAIRLAKELKVDRISVADTTGSTHPLRFYTLVKKIVN 180
D + F+ ED +RT NL R + V I++ DT G T P ++K +
Sbjct: 121 DD----IEFSCEDASRTTMDNLCRIVEKLIYCGVKTINIPDTVGYTVPNELSGVIKNLFE 176
Query: 181 FGIP------VNVHCHNDLGLALANAIMGIEAGATLVDATVNGLGERAGIVDLAQIITVL 234
+P ++VHCHNDLG+A+ N+I I+AGA ++ T+NG+GERAG L ++I +
Sbjct: 177 -RVPNIHKSIISVHCHNDLGMAVGNSISAIQAGARQIEGTINGIGERAGNTALEEVIMAI 235
Query: 235 YYHYGIKKYRLDL----LYRVSNLVSEITGISPQPNYPIVGENAFTHKAGLHVSAVLKDP 290
I ++ +Y+ S ++S I I N IVG NAF+H +G+H VLK+
Sbjct: 236 KVREDILGVSTNINHKEIYQTSQIISRICNIPVPSNKAIVGSNAFSHSSGIHQDGVLKNR 295
Query: 291 RFYEFLPAEVFGRERT-IYVDRYAGKDTIRYYLEKFGIRD 329
YE + G ++ + + +G+ ++YY+ G +D
Sbjct: 296 ENYEIMDPNSIGLKKVKLNLTSRSGRAAVKYYMNYMGYKD 335
>pir||S40588 hypothetical protein - Escherichia coli >gi|216492|dbj|BAA01343.1|
(D10483) 2-Isopropylmalate synthase homolog(PIR:S08431)
[Escherichia coli]
Length = 523
Score = 170 bits (426), Expect = 3e-41
Identities = 104/343 (30%), Positives = 182/343 (52%), Gaps = 14/343 (4%)
Query: 1 MVLDSTLREGEQTPGVNYTPEQRLEIAIALDEVGVDFIEIGHPAVSEDVFRGMKLIAEQG 60
++ D+TLR+GEQ + + +++L+IA+AL+ +GVD +E+G P S F ++ IA Q
Sbjct: 6 IIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQV 65
Query: 61 LNVELLAHSRALIEDIDYV---LKTGVDW-VGIFFCLSEACLRKRFRITLDHALEKISRA 116
N + A +R + +DID LK + + F S + + R TLD +E+
Sbjct: 66 KNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYM 125
Query: 117 IEYAKDHGLKVRFTPEDTTRTEWANLKRAIRLAKELKVDRISVADTTGSTHPLRFYTLV- 175
++ A+++ V F+ ED RT A+L R + A I++ DT G T P F ++
Sbjct: 126 VKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGIIS 185
Query: 176 ---KKIVNFG-IPVNVHCHNDLGLALANAIMGIEAGATLVDATVNGLGERAGIVDLAQII 231
+++ + G ++VH H+DLGLA+ N++ + AGA V+ +NG+GERAG L ++I
Sbjct: 186 GLYERVPSIGKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEVI 245
Query: 232 TVLYYHYGIKKYRLDL----LYRVSNLVSEITGISPQPNYPIVGENAFTHKAGLHVSAVL 287
+ I + ++R S LVS+I + N IVG AF H +G+H VL
Sbjct: 246 MAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGVL 305
Query: 288 KDPRFYEFLPAEVFG-RERTIYVDRYAGKDTIRYYLEKFGIRD 329
K+ YE + E G + + + +G+ +++ +++ G ++
Sbjct: 306 KNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKE 348
>pir||G81125 2-isopropylmalate synthase NMB1070 [imported] - Neisseria
meningitidis (group B strain MD58)
>gi|7226309|gb|AAF41465.1| (AE002457) 2-isopropylmalate
synthase [Neisseria meningitidis MC58]
Length = 517
Score = 170 bits (426), Expect = 3e-41
Identities = 111/341 (32%), Positives = 174/341 (50%), Gaps = 14/341 (4%)
Query: 1 MVLDSTLREGEQTPGVNYTPEQRLEIAIALDEVGVDFIEIGHPAVSEDVFRGMKLIAEQG 60
++ D+TLR+GEQ+PG T E+++ +A L+++GVD IE G A S F + IA+
Sbjct: 8 IIFDTTLRDGEQSPGAAMTKEEKIRVARQLEKLGVDIIEAGFAAASPGDFEAVNAIAKTI 67
Query: 61 LNVELLAHSRALIEDI----DYVLKTGVDWVGIFFCLSEACLRKRFRITLDHALEKISRA 116
+ + SRA+ DI + V + F S + + ++ +E +A
Sbjct: 68 TKSTVCSLSRAIERDIRQAGEAVAPAPKKRIHTFIATSPIHMEYKLKMKPKQVIEAAVKA 127
Query: 117 IEYAKDHGLKVRFTPEDTTRTEWANLKRAIRLAKELKVDRISVADTTGSTHPLR----FY 172
++ A+++ V F+ ED R+E L E I++ DT G + P + F
Sbjct: 128 VKIAREYTDDVEFSCEDALRSEIDFLAEICGAVIEAGATTINIPDTVGYSIPYKTEEFFR 187
Query: 173 TLVKKIVNFGIPV-NVHCHNDLGLALANAIMGIEAGATLVDATVNGLGERAGIVDLAQII 231
L+ K N G V + HCHNDLGLA+AN++ ++ GA V+ TVNGLGERAG + +I+
Sbjct: 188 ELIAKTPNGGKVVWSAHCHNDLGLAVANSLAALKGGARQVECTVNGLGERAGNASVEEIV 247
Query: 232 TVLYYHYGIKKYRLDL----LYRVSNLVSEITGISPQPNYPIVGENAFTHKAGLHVSAVL 287
L + + + + S LVS ITG QPN IVG NAF+H++G+H VL
Sbjct: 248 MALKVRHDLFGLETGIDTTQIVPSSKLVSTITGYPVQPNKAIVGANAFSHESGIHQDGVL 307
Query: 288 KDPRFYEFLPAEVFG-RERTIYVDRYAGKDTIRYYLEKFGI 327
K YE + AE G + + + +G++ + L GI
Sbjct: 308 KHRETYEIMSAESVGWATNRLSLGKLSGRNAFKTKLADLGI 348
>gb|AAG31401.1| (AF197456) 2-isopropylmaltate synthase [Buchnera aphidicola]
Length = 502
Score = 170 bits (426), Expect = 3e-41
Identities = 103/340 (30%), Positives = 184/340 (53%), Gaps = 24/340 (7%)
Query: 9 EGEQTPGVNYTPEQRLEIAIALDEVGVDFIEIGHPAVSEDVFRGMKLIAEQGLNVELLAH 68
+GEQ + + +++L+IA+ L+++GVD +EIG P S F+ +++I++ N + +
Sbjct: 1 DGEQALQASLSVKEKLQIALCLEKIGVDIMEIGFPISSPGDFKSVQIISKNIKNSRICSL 60
Query: 69 SRALIEDIDY----VLKTGVDWVGIFFCLS----EACLRKRFRITLDHALEKISRAIEYA 120
+R + +DID + + + IF S E L+K F +D A+ + RA+ Y
Sbjct: 61 ARCVEKDIDAAGEAMSASNSFRIHIFLATSTLHMEYKLKKNFHEIIDMAIFAVKRALRYT 120
Query: 121 KDHGLKVRFTPEDTTRTEWANLKRAIRLAKELKVDRISVADTTGSTHPLRFYTLVKKIVN 180
D + F+ ED +RT NL R + V I++ DT G T P ++K ++
Sbjct: 121 DD----IEFSCEDASRTTIDNLCRIVEKLIYHGVKTINIPDTVGYTVPNELSYIIKNLLE 176
Query: 181 FGIP------VNVHCHNDLGLALANAIMGIEAGATLVDATVNGLGERAGIVDLAQIITVL 234
+P ++VHCH+DLG+A+ N+I I+AGA ++ T+NG+GERAG L ++I +
Sbjct: 177 -RVPNIHKSIISVHCHDDLGMAVGNSISAIQAGARQIEGTINGIGERAGNTALEEVIMAI 235
Query: 235 YYHYGIKKYRLDL----LYRVSNLVSEITGISPQPNYPIVGENAFTHKAGLHVSAVLKDP 290
I ++ +Y S ++S I + PN IVG NAF+H +G+H VLK+
Sbjct: 236 KVREDILGVSTNINYKEIYHTSKIISRICNMPIPPNKAIVGSNAFSHSSGIHQDGVLKNR 295
Query: 291 RFYEFL-PAEVFGRERTIYVDRYAGKDTIRYYLEKFGIRD 329
+ YE + P+ + ++ + + +G+ ++YY+ + G +D
Sbjct: 296 KNYEIIDPSSIGFKKLKLNLTSRSGRAAVKYYMSEMGYKD 335
>gb|AAG31404.1| (AF197457) 2-isopropylmaltate synthase [Buchnera aphidicola]
Length = 506
Score = 170 bits (426), Expect = 3e-41
Identities = 103/337 (30%), Positives = 183/337 (53%), Gaps = 24/337 (7%)
Query: 9 EGEQTPGVNYTPEQRLEIAIALDEVGVDFIEIGHPAVSEDVFRGMKLIAEQGLNVELLAH 68
+GEQ + + +++L+IA++L++ G+D +EIG P S F+ ++ I++ N + +
Sbjct: 1 DGEQALQASLSVKEKLQIALSLEKCGIDILEIGFPVSSPGDFKSVQTISKNIKNSRICSL 60
Query: 69 SRALIEDIDY----VLKTGVDWVGIFFCLS----EACLRKRFRITLDHALEKISRAIEYA 120
+R + +DID + + + IF S E+ L+K F +D A+ + +A+ Y
Sbjct: 61 ARCIEKDIDAAGEAMSSSDSFRIHIFLATSTLHMESKLKKNFNEIIDMAVFSVKKALRYT 120
Query: 121 KDHGLKVRFTPEDTTRTEWANLKRAIRLAKELKVDRISVADTTGSTHPLRFYTLVKKIVN 180
D + F+ ED TRT NL R + + V I++ DT G T P ++K +
Sbjct: 121 DD----IEFSCEDATRTTMDNLCRIVETLIKSGVKTINIPDTVGYTVPNELSCIIKNLFE 176
Query: 181 FGIP------VNVHCHNDLGLALANAIMGIEAGATLVDATVNGLGERAGIVDLAQIITVL 234
+P ++VHCH+DLG+A+ N+I I+AGA ++ T+NG+GERAG L +II +
Sbjct: 177 -RVPNIHKSIISVHCHDDLGMAVGNSISAIQAGARQIEGTINGIGERAGNTALEEIIMAI 235
Query: 235 YYHYGIKKYRLDL----LYRVSNLVSEITGISPQPNYPIVGENAFTHKAGLHVSAVLKDP 290
I ++ +YR S +VS+I + N IVG NAF H +G+H VLK+
Sbjct: 236 KVREDILSVSTNINYKEIYRTSKIVSQICNMPIPSNKAIVGSNAFAHSSGIHQDGVLKNR 295
Query: 291 RFYEFL-PAEVFGRERTIYVDRYAGKDTIRYYLEKFG 326
+ YE + P+ + +E + + +G+ +++Y+++ G
Sbjct: 296 KNYEIMEPSSIGLKEVKLNLTSRSGRAAVKHYMDEMG 332
>pir||C81895 probable 2-isopropylmalate synthase (EC 4.1.3.12) NMA1270
[imported] - Neisseria meningitidis (group A strain
Z2491) >gi|7379949|emb|CAB84524.1| (AL162755) putative
2-isopropylmalate synthase [Neisseria meningitidis
Z2491]
Length = 517
Score = 169 bits (425), Expect = 3e-41
Identities = 111/341 (32%), Positives = 174/341 (50%), Gaps = 14/341 (4%)
Query: 1 MVLDSTLREGEQTPGVNYTPEQRLEIAIALDEVGVDFIEIGHPAVSEDVFRGMKLIAEQG 60
++ D+TLR+GEQ+PG T E+++ +A L+++GVD IE G A S F + IA+
Sbjct: 8 IIFDTTLRDGEQSPGAAMTKEEKIRVARQLEKLGVDIIEAGFAAASPGDFEAVNAIAKTI 67
Query: 61 LNVELLAHSRALIEDI----DYVLKTGVDWVGIFFCLSEACLRKRFRITLDHALEKISRA 116
+ + SRA+ DI + V + F S + + ++ +E +A
Sbjct: 68 TKSTVCSLSRAIERDIRQAGEAVAPAPKKRIHTFIATSPIHMEYKLKMKPKQVIEAAVKA 127
Query: 117 IEYAKDHGLKVRFTPEDTTRTEWANLKRAIRLAKELKVDRISVADTTGSTHPLR----FY 172
++ A+++ V F+ ED R+E L E I++ DT G + P + F
Sbjct: 128 VKIAREYTDDVEFSCEDALRSEIDFLAEICGAVIEAGATTINIPDTVGYSIPYKTEEFFR 187
Query: 173 TLVKKIVNFGIPV-NVHCHNDLGLALANAIMGIEAGATLVDATVNGLGERAGIVDLAQII 231
L+ K N G V + HCHNDLGLA+AN++ ++ GA V+ TVNGLGERAG + +I+
Sbjct: 188 ELIVKTPNGGKVVWSAHCHNDLGLAVANSLAALKGGARQVECTVNGLGERAGNASVEEIV 247
Query: 232 TVLYYHYGIKKYRLDL----LYRVSNLVSEITGISPQPNYPIVGENAFTHKAGLHVSAVL 287
L + + + + S LVS ITG QPN IVG NAF+H++G+H VL
Sbjct: 248 MALKVRHDLFGLETGIDTTQIVPSSKLVSTITGYPVQPNKAIVGANAFSHESGIHQDGVL 307
Query: 288 KDPRFYEFLPAEVFG-RERTIYVDRYAGKDTIRYYLEKFGI 327
K YE + AE G + + + +G++ + L GI
Sbjct: 308 KHRETYEIMSAESVGWATNRLSLGKLSGRNAFKTKLADLGI 348
>sp|P94907|LEU1_MICAE 2-ISOPROPYLMALATE SYNTHASE (ALPHA-ISOPROPYLMALATE SYNTHASE)
(ALPHA-IPM SYNTHETASE) >gi|1783285|dbj|BAA12849.1|
(D85684) 2-isopropylmalate synthase [Microcystis
aeruginosa]
Length = 533
Score = 169 bits (424), Expect = 4e-41
Identities = 112/356 (31%), Positives = 177/356 (49%), Gaps = 31/356 (8%)
Query: 1 MVLDSTLREGEQTPGVNYTPEQRLEIAIALDEVGVDFIEIGHPAVSEDVFRGMKLIA--- 57
++ D+TLR+GEQ+PG +++L IA AL +GVD IE G P S F ++ IA
Sbjct: 9 IIFDTTLRDGEQSPGAALNVDEKLTIARALARLGVDVIEAGFPHASPGDFEAVQKIAGSV 68
Query: 58 -EQGLNVELLAHSRALIEDI----DYVLKTGVDWVGIFFCLSEACLRKRFRITLDHALEK 112
+ + + +RA +DI D + + F S+ L+ + + T LE
Sbjct: 69 GSEADSPIICGLARATQKDIKSAADALRPAAKPRIHTFLATSDIHLQYKLKKTRQEVLEI 128
Query: 113 ISRAIEYAKDHGLKVRFTPEDTTRTEWANLKRAIRLAKELKVDRISVADTTGSTHPLRFY 172
+ + YAK V F+PED R++ L + + A +++ DT G T P F
Sbjct: 129 VPEMVAYAKSFLNDVEFSPEDAGRSDPEFLYQVLERAIAAGATTVNIPDTVGYTTPSEFG 188
Query: 173 TLVKKIVNFGIP------VNVHCHNDLGLALANAIMGIEAGATLVDATVNGLGERAGIVD 226
L++ I +P ++VH H+DLGLA+AN + ++ GA ++ T+NG+GERAG
Sbjct: 189 ALIRGIKE-NVPNIDQAIISVHGHDDLGLAVANFLEAVKNGARQLECTINGIGERAGNAS 247
Query: 227 LAQIITVLYYHYG---------------IKKYRLDLLYRVSNLVSEITGISPQPNYPIVG 271
L +++ L+ + K +YR S LVS +TG+ QPN IVG
Sbjct: 248 LEELVMALHVRRSYFNPFLGRPAESTEPLTKINTKEIYRTSRLVSNLTGMIVQPNKAIVG 307
Query: 272 ENAFTHKAGLHVSAVLKDPRFYEFLPAEVFG-RERTIYVDRYAGKDTIRYYLEKFG 326
NAF H++G+H VLK YE + AE G I + + +G++ R L++ G
Sbjct: 308 ANAFAHESGIHQDGVLKHKLTYEIMDAESIGLTNNQIVLGKLSGRNAFRSRLQELG 363
>sp|P09151|LEU1_ECOLI 2-ISOPROPYLMALATE SYNTHASE (ALPHA-ISOPROPYLMALATE SYNTHASE)
(ALPHA-IPM SYNTHETASE) >gi|7447053|pir||B64729
2-isopropylmalate synthase (EC 4.1.3.12) - Escherichia
coli >gi|1786261|gb|AAC73185.1| (AE000117)
2-isopropylmalate synthase [Escherichia coli K12]
Length = 523
Score = 169 bits (424), Expect = 4e-41
Identities = 104/343 (30%), Positives = 181/343 (52%), Gaps = 14/343 (4%)
Query: 1 MVLDSTLREGEQTPGVNYTPEQRLEIAIALDEVGVDFIEIGHPAVSEDVFRGMKLIAEQG 60
++ D+TLR+GEQ + + +++L+IA+AL+ +GVD +E+G P S F ++ IA Q
Sbjct: 6 IIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQV 65
Query: 61 LNVELLAHSRALIEDIDYV---LKTGVDW-VGIFFCLSEACLRKRFRITLDHALEKISRA 116
N + A +R + +DID LK + + F S + + R TLD +E+
Sbjct: 66 KNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYM 125
Query: 117 IEYAKDHGLKVRFTPEDTTRTEWANLKRAIRLAKELKVDRISVADTTGSTHPLRFYTLV- 175
++ A+++ V F+ ED RT A+L R + A I++ DT G T P F ++
Sbjct: 126 VKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGIIS 185
Query: 176 ---KKIVNFG-IPVNVHCHNDLGLALANAIMGIEAGATLVDATVNGLGERAGIVDLAQII 231
+++ N ++VH H+DLGLA+ N++ + AGA V+ +NG+GERAG L ++I
Sbjct: 186 GLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEVI 245
Query: 232 TVLYYHYGIKKYRLDL----LYRVSNLVSEITGISPQPNYPIVGENAFTHKAGLHVSAVL 287
+ I + ++R S LVS+I + N IVG AF H +G+H VL
Sbjct: 246 MAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGVL 305
Query: 288 KDPRFYEFLPAEVFG-RERTIYVDRYAGKDTIRYYLEKFGIRD 329
K+ YE + E G + + + +G+ +++ +++ G ++
Sbjct: 306 KNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKE 348
>sp|P48576|LEU1_SYNY3 2-ISOPROPYLMALATE SYNTHASE (ALPHA-ISOPROPYLMALATE SYNTHASE)
(ALPHA-IPM SYNTHETASE) >gi|7447052|pir||S76101
hypothetical protein - Synechocystis sp. (strain PCC
6803) >gi|1001454|dbj|BAA10079.1| (D63999)
2-isopropylmalate synthase [Synechocystis sp.]
Length = 533
Score = 169 bits (423), Expect = 6e-41
Identities = 113/356 (31%), Positives = 177/356 (48%), Gaps = 32/356 (8%)
Query: 1 MVLDSTLREGEQTPGVNYTPEQRLEIAIALDEVGVDFIEIGHPAVSEDVFRGMKLIAEQG 60
++ D+TLR+GEQ+PG T E++L IA AL +GVD IE G P S F ++ IA Q
Sbjct: 9 LIFDTTLRDGEQSPGATLTVEEKLSIARALARLGVDIIEAGFPFASPGDFEAVQKIA-QT 67
Query: 61 LNVE----LLAHSRALIEDI----DYVLKTGVDWVGIFFCLSEACLRKRFRITLDHALEK 112
+ E + +RA +DI + + + F S+ L + + T L
Sbjct: 68 VGTENGPVICGLARATQKDIKAAAEALKPAAKHRIHTFLATSDIHLEHKLKKTRAEVLAI 127
Query: 113 ISRAIEYAKDHGLKVRFTPEDTTRTEWANLKRAIRLAKELKVDRISVADTTGSTHPLRFY 172
+ + YAK + F+PED R++ L + + A I++ DT G T P +
Sbjct: 128 VPEMVAYAKSLVNDIEFSPEDAGRSDPEFLYQVLEAAISAGATTINIPDTVGYTTPAEYG 187
Query: 173 TLVKKIVNFGIP------VNVHCHNDLGLALANAIMGIEAGATLVDATVNGLGERAGIVD 226
L+K I + +P ++VH HNDLGLA+AN + ++ GA ++ T+NG+GERAG
Sbjct: 188 ALIKGIAD-NVPNIDQAIISVHGHNDLGLAVANFLEAVKNGARQLECTINGIGERAGNAA 246
Query: 227 LAQIITVLYYHYG---------------IKKYRLDLLYRVSNLVSEITGISPQPNYPIVG 271
L +++ L+ + +Y S LVSE+TG+ QPN IVG
Sbjct: 247 LEELVMALHVRRSYFNPFLGRPADSTAPLTNIDTKHIYATSRLVSELTGMMVQPNKAIVG 306
Query: 272 ENAFTHKAGLHVSAVLKDPRFYEFLPAEVFG-RERTIYVDRYAGKDTIRYYLEKFG 326
NAF H++G+H VLK+ YE + AE G I + + +G++ L++ G
Sbjct: 307 ANAFAHESGIHQDGVLKNKLTYEIMDAESIGLTNNQIVLGKLSGRNAFGTRLKELG 362
>sp|Q52070|NIFV_ENTAG HOMOCITRATE SYNTHASE >gi|1480128|emb|CAA68021.1| (X99694) nifV
[Enterobacter agglomerans]
Length = 400
Score = 167 bits (419), Expect = 2e-40
Identities = 108/353 (30%), Positives = 181/353 (50%), Gaps = 9/353 (2%)
Query: 1 MVLDSTLREGEQTPGVNYTPEQRLEIAIALDEVGVDFIEIGHPAVSEDVFRGMKLIAEQG 60
++ D+TLR+GEQ+PGV + ++LEIA AL GV +E G PA+ E+ + ++ Q
Sbjct: 19 IINDTTLRDGEQSPGVAFRASEKLEIAQALVNAGVRELEAGTPALGEEECVRLAILRRQL 78
Query: 61 LNVELLAHSRALIEDIDYVLKTGVDWVGIFFCLSEACLRKRFRITLDHALEKISRAIEYA 120
+ +++ R +I + G+DWV I S+ ++ + + ++ A
Sbjct: 79 PDTVMMSWCRMNSAEIHDSARVGMDWVDISVPASDLLREQKLHRPWPAVIASLKPLVQLA 138
Query: 121 KDHGLKVRFTPEDTTRTEWANLKRAIRLAKELKVDRISVADTTGSTHPLRFYTLVKKI-V 179
G++V ED +R+ L +A +L ++R+ ADT G P +T + +
Sbjct: 139 HRLGMRVCMGCEDASRSADETLHMLAEVAADLGIERMRFADTLGILDPFSTFTRISALRQ 198
Query: 180 NFGIPVNVHCHNDLGLALANAIMGIEAGATLVDATVNGLGERAGIVDLAQII----TVLY 235
++ + +H HNDLG+A AN + + AGAT V+ TV GLGERAG L + L+
Sbjct: 199 HWHGGLEIHAHNDLGMATANTLAAVRAGATHVNTTVLGLGERAGNAALESVTLSLDRCLH 258
Query: 236 YHYGIKKYRLDLLYRVSNLVSEITGISPQPNYPIVGENAFTHKAGLHVSAVLKDPRFYEF 295
GI L L R LV+ G + +P+VG FTH++GLHV+A+L+DPR Y+
Sbjct: 259 LDCGIDFTELPALCR---LVAAAAGRTIDVQHPLVGGQVFTHESGLHVAALLRDPRSYQG 315
Query: 296 LPAEVFGRERTIYVDRYAGKDTIRYYLEKFG-IRDHGIVTSLLRKVKSSREPF 347
+ + GRE + + +++G+ + + G I +L++VK E F
Sbjct: 316 IDPSLVGREFNLVLGKHSGRQAVSGICARLGYILSETQTLLMLQEVKRFAEHF 368
>dbj|BAB09819.1| (AB006708) 2-isopropylmalate synthase-like protein [Arabidopsis
thaliana]
Length = 503
Score = 167 bits (418), Expect = 2e-40
Identities = 116/354 (32%), Positives = 180/354 (50%), Gaps = 29/354 (8%)
Query: 2 VLDSTLREGEQTPGVNYTPEQRLEIAIALDEVGVDFIEIGHPAVSEDVFRGMKLIA---- 57
VLD+TLR+GEQ+PG TP Q+LEIA L ++ VD +E+G P SE+ F +K IA
Sbjct: 87 VLDTTLRDGEQSPGAALTPPQKLEIARQLAKLRVDIMEVGFPVSSEEEFEAIKTIAKTVG 146
Query: 58 -----EQGLNVELLAHSRALIEDIDYVLK----TGVDWVGIFFCLSEACLRKRFRITLDH 108
E G + +R DI+ + V +F SE ++ + + T +
Sbjct: 147 NEVDEETGYVPVICGIARCKKRDIEATWEALKYAKRPRVMLFTSTSEIHMKYKLKKTKEE 206
Query: 109 ALEKISRAIEYAKDHGLK-VRFTPEDTTRTEWANLKRAIRLAKELKVDRISVADTTGSTH 167
+E +++YAK G K ++F ED RTE + + + + + + ADT G
Sbjct: 207 VIEMAVNSVKYAKSLGFKDIQFGCEDGGRTEKDFICKILGESIKAGATTVGFADTVGINM 266
Query: 168 PLRFYTLVKKIVN-----FGIPVNVHCHNDLGLALANAIMGIEAGATLVDATVNGLGERA 222
P F LV ++ I +HCHNDLG+A AN I GI AGA V+ T+NG+GER+
Sbjct: 267 PQEFGELVAYVIENTPGADDIVFAIHCHNDLGVATANTISGICAGARQVEVTINGIGERS 326
Query: 223 GIVDLAQIITVLYYH-----YGI-KKYRLDLLYRVSNLVSEITGISPQPNYPIVGENAFT 276
G L +++ L G+ K + S +V E TG+ QP+ PIVG+N F
Sbjct: 327 GNAPLEEVVMALKCRGESLMDGVYTKIDSRQIMATSKMVQEHTGMYVQPHKPIVGDNCFV 386
Query: 277 HKAGLHVSAVLKDPRFYEFLPAEVFGRERT----IYVDRYAGKDTIRYYLEKFG 326
H++G+H +LK+ YE L E G ++ I + + +G+ ++ L++ G
Sbjct: 387 HESGIHQDGILKNRSTYEILSPEDVGIVKSENSGIVLGKLSGRHAVKDRLKELG 440
>sp|P05342|NIFV_AZOVI HOMOCITRATE SYNTHASE >gi|420863|pir||S29758 nifV protein -
Azotobacter vinelandii >gi|142362|gb|AAA64727.1|
(M20568) homocitrate synthase (nifV) [Azotobacter
vinelandii]
Length = 385
Score = 166 bits (415), Expect = 5e-40
Identities = 110/330 (33%), Positives = 171/330 (51%), Gaps = 10/330 (3%)
Query: 4 DSTLREGEQTPGVNYTPEQRLEIAIALDEVGVDFIEIGHPAVSEDVFRGMKLIAEQGLNV 63
D+TLR+GEQ+ GV + ++++ IA AL E+GV +EIG P++ E+ M IA GL+
Sbjct: 8 DTTLRDGEQSAGVAFNADEKIAIARALAELGVPELEIGIPSMGEEEREVMHAIAGLGLSS 67
Query: 64 ELLAHSRALIEDIDYVLKTGVDWVGIFFCLSEACLRKRFRITLDHALEKISRAIEYAKDH 123
LLA R D+ TGV V + +S+ L + D AL +++R + A+
Sbjct: 68 RLLAWCRLCDVDLAAARSTGVTMVDLSLPVSDLMLHHKLNRDRDWALREVARLVGEARMA 127
Query: 124 GLKVRFTPEDTTRTEWANLKRAIRLAKELKVDRISVADTTGSTHPL----RFYTLVKKIV 179
GL+V ED +R + + + +A+ R+ ADT G P RF L +++
Sbjct: 128 GLEVCLGCEDASRADLEFVVQVGEVAQAAGARRLRFADTVGVMEPFGMLDRFRFLSRRL- 186
Query: 180 NFGIPVNVHCHNDLGLALANAIMGIEAGATLVDATVNGLGERAGIVDLAQIITVLYYHYG 239
+ + VH H+D GLA AN + + GAT ++ TVNGLGERAG L + + L +G
Sbjct: 187 --DMELEVHAHDDFGLATANTLAAVMGGATHINTTVNGLGERAGNAALEECVLALKNLHG 244
Query: 240 IKKYRLDL--LYRVSNLVSEITGISPQPNYPIVGENAFTHKAGLHVSAVLKDPRFYEFLP 297
I +D + +S LV +G +VG FTH+AG+HV +LK R YE L
Sbjct: 245 IDT-GIDTRGIPAISALVERASGRQVAWQKSVVGAGVFTHEAGIHVDGLLKHRRNYEGLN 303
Query: 298 AEVFGRERTIYVDRYAGKDTIRYYLEKFGI 327
+ GR ++ + +++G +R GI
Sbjct: 304 PDELGRSHSLVLGKHSGAHMVRNTYRDLGI 333
>sp|Q9WZ22|LY41_THEMA PUTATIVE LYASE TM0552 >gi|7447065|pir||F72362 hypothetical protein
TM0552 - Thermotoga maritima (strain MSB8)
>gi|4981067|gb|AAD35637.1|AE001730_5 (AE001730)
2-isopropylmalate synthase, putative [Thermotoga
maritima]
Length = 538
Score = 166 bits (415), Expect = 5e-40
Identities = 114/359 (31%), Positives = 187/359 (51%), Gaps = 19/359 (5%)
Query: 2 VLDSTLREGEQTPGVNYTPEQRLEIAIALDEVGVDFIEIGHPAVS-EDV--FRGMKLIAE 58
V D+TLR+G Q GV+++ E ++ IA ALD++GV ++E G P + +D+ F +K +
Sbjct: 5 VYDTTLRDGAQAFGVSFSLEDKIRIAEALDDLGVHYLEGGWPGSNPKDIAFFEAVKGMNF 64
Query: 59 QGLNVELLAHSRA----LIED--IDYVLKTGVDWVGIFFCLSEACLRKRFRITLDHALEK 112
+ L V + +R + ED I ++K IF + + K R TL+ L+
Sbjct: 65 KNLKVAAFSSTRRPDVKIEEDANIQTLIKAETPVYTIFGKSWDLHVEKALRTTLEENLKM 124
Query: 113 ISRAIEYAKDHGLKVRFTPEDTTRTEWANLKRAIR---LAKELKVDRISVADTTGSTHPL 169
I + Y K +V + E AN + A++ +A+E D + +ADT G T P
Sbjct: 125 IYDTVSYLKRFADEVIYDAEHFFDGYKANREYALKTLKVAEEAGADCLVLADTNGGTLPH 184
Query: 170 RFYTLVKKIV-NFGIPVNVHCHNDLGLALANAIMGIEAGATLVDATVNGLGERAGIVDLA 228
+++ + + P+ +H HND +A+AN + + GA V T+NGLGER G +L
Sbjct: 185 EIEEIIEDVKKHVKAPLGIHAHNDSDVAVANTLAAVRKGAVHVQGTINGLGERCGNANLC 244
Query: 229 QIITVLYYHYGIK---KYRLDLLYRVSNLVSEITGISPQPNYPIVGENAFTHKAGLHVSA 285
+I L G++ K L L+ V++LV+E++G N P VG+ AF HK G+HVSA
Sbjct: 245 SVIPNLVLKMGLEVIPKENLKKLFDVAHLVAELSGRPHIENMPYVGDYAFAHKGGVHVSA 304
Query: 286 VLKDPRFYEFLPAEVFGRERTIYVDRYAGKDTIRYYLEKFGI---RDHGIVTSLLRKVK 341
+ +DPR YE + E+ G R I + +GK + +++ G V +L+K+K
Sbjct: 305 IKRDPRTYEHIDPELVGNRRIISISELSGKSNVLEKIKEMGFEIDESSPKVREILKKIK 363
>gb|AAG31927.1|AF200469_1 (AF200469) 2-isopropylmalate synthase [Buchnera aphidicola]
Length = 502
Score = 166 bits (415), Expect = 5e-40
Identities = 103/341 (30%), Positives = 182/341 (53%), Gaps = 24/341 (7%)
Query: 9 EGEQTPGVNYTPEQRLEIAIALDEVGVDFIEIGHPAVSEDVFRGMKLIAEQGLNVELLAH 68
+GEQ + + +++L+IA+ L++ GVD +E+G P S F+ ++ I+++ + + +
Sbjct: 1 DGEQALQASLSVKEKLQIALCLEKSGVDIMEVGFPISSPGDFKSVQTISQKIKHSRVCSL 60
Query: 69 SRALIEDIDY----VLKTGVDWVGIFFCLS----EACLRKRFRITLDHALEKISRAIEYA 120
+R + +DID + + + IF S E+ L+K F +D A+ + RA+ Y
Sbjct: 61 ARCIEKDIDVAGEAMSASDSFRIHIFLATSTLHMESKLKKNFNEIIDMAIFSVKRALRYT 120
Query: 121 KDHGLKVRFTPEDTTRTEWANLKRAIRLAKELKVDRISVADTTGSTHPLRFYTLVKKIVN 180
D V F+ ED +RT NL R + V I++ DT G T P ++K +
Sbjct: 121 DD----VEFSCEDASRTTIDNLCRIVEKLISCGVKTINIPDTVGYTIPNELSFIIKNLFE 176
Query: 181 FGIP------VNVHCHNDLGLALANAIMGIEAGATLVDATVNGLGERAGIVDLAQIITVL 234
+P ++VHCHNDLG+A+ N+I I+AGA ++ T+NG+GERAG L ++I +
Sbjct: 177 -RVPNIHKSTISVHCHNDLGMAVGNSISAIQAGARQIEGTINGIGERAGNTALEEVIMAI 235
Query: 235 YYHYGIKKYRLDL----LYRVSNLVSEITGISPQPNYPIVGENAFTHKAGLHVSAVLKDP 290
I ++ +YR S +VS I + N IVG NAF+H +G+H VLK+
Sbjct: 236 KVREDILGLSTNINHKEIYRTSQIVSSICNMPIPSNKAIVGSNAFSHSSGIHQDGVLKNR 295
Query: 291 RFYEFL-PAEVFGRERTIYVDRYAGKDTIRYYLEKFGIRDH 330
YE + P + ++ + + +G+ ++YY+ + G +++
Sbjct: 296 ENYEIIDPISIGLKKVKLNLTSRSGRAAVKYYMNEMGYKEN 336
>gb|AAF36732.1| (AC016662) putative 2-isopropylmalate synthase; 30920-27612
[Arabidopsis thaliana]
Length = 631
Score = 165 bits (414), Expect = 6e-40
Identities = 115/373 (30%), Positives = 188/373 (49%), Gaps = 29/373 (7%)
Query: 2 VLDSTLREGEQTPGVNYTPEQRLEIAIALDEVGVDFIEIGHPAVSEDVFRGMKLIA---- 57
+ D+TLR+GEQ+PG T +++L+IA L ++GVD IE G PA S+D F +K IA
Sbjct: 89 IFDTTLRDGEQSPGATLTSKEKLDIARQLAKLGVDIIEAGFPAASKDDFEAVKTIAETVG 148
Query: 58 ----EQGLNVELLAHSRALIEDI----DYVLKTGVDWVGIFFCLSEACLRKRFRITLDHA 109
E G + SR +DI + V + F S+ L+ + + + +
Sbjct: 149 NTVDENGYVPVICGLSRCNKKDIETAWEAVKYAKRPRIHTFIATSDIHLKYKLKKSKEEV 208
Query: 110 LEKISRAIEYAKDHGLK-VRFTPEDTTRTEWANLKRAIRLAKELKVDRISVADTTGSTHP 168
+E + +A+ G + V F+PED R+E L + + +++ DT G T P
Sbjct: 209 IEIARNMVRFARSLGCEDVEFSPEDAGRSEREYLYEILGEVIKAGATTLNIPDTVGITLP 268
Query: 169 LRFYTLVKKIVN-----FGIPVNVHCHNDLGLALANAIMGIEAGATLVDATVNGLGERAG 223
F L+ I + ++ HC NDLGL+ AN + G +GA V+ T+NG+GERAG
Sbjct: 269 SEFGQLIADIKANTPGIQNVIISTHCQNDLGLSTANTLSGAHSGARQVEVTINGIGERAG 328
Query: 224 IVDLAQIITVLY----YHYGIKKYRLDLLYRV--SNLVSEITGISPQPNYPIVGENAFTH 277
L +++ + + G +D + V S +V E TG+ QP+ IVG NAF H
Sbjct: 329 NASLEEVVMAIKCRGDHVLGGLFTGIDTRHIVMTSKMVEEYTGMQTQPHKAIVGANAFAH 388
Query: 278 KAGLHVSAVLKDPRFYEFLPAEVFGRERT----IYVDRYAGKDTIRYYLEKFG-IRDHGI 332
++G+H +LK YE + E G ER+ I + + +G+ ++ L + G + D G
Sbjct: 389 ESGIHQDGMLKHKGTYEIMSPEEIGLERSNDAGIVLGKLSGRHALKDRLNELGYVLDDGQ 448
Query: 333 VTSLLRKVKSSRE 345
+++L + K+ E
Sbjct: 449 LSNLFWRFKAVAE 461
>gb|AAG31395.1| (AF197454) 2-isopropylmaltate synthase [Buchnera aphidicola]
Length = 503
Score = 164 bits (412), Expect = 1e-39
Identities = 102/341 (29%), Positives = 181/341 (52%), Gaps = 24/341 (7%)
Query: 9 EGEQTPGVNYTPEQRLEIAIALDEVGVDFIEIGHPAVSEDVFRGMKLIAEQGLNVELLAH 68
+GEQ + + +++L+IA+ L++ GVD +E+G P S F+ ++ I+++ N + +
Sbjct: 1 DGEQALQASLSVKEKLQIALCLEKSGVDIMEVGFPISSPGDFKSVQTISQKIKNSRVCSL 60
Query: 69 SRALIEDIDY----VLKTGVDWVGIFFCLS----EACLRKRFRITLDHALEKISRAIEYA 120
+R + +DID + + + IF S E+ LRK F +D A+ + RA+ Y
Sbjct: 61 ARCIEKDIDVAGEAMSASNSFRIHIFLATSTLHMESKLRKNFNEIIDMAIFSVKRALRYT 120
Query: 121 KDHGLKVRFTPEDTTRTEWANLKRAIRLAKELKVDRISVADTTGSTHPLRFYTLVKKIVN 180
D + F+ ED +RT NL R + V I++ DT G T P ++K +
Sbjct: 121 DD----IEFSCEDASRTTIDNLCRIVEKLISCGVKTINIPDTVGYTIPNELSFIIKNLFE 176
Query: 181 FGIP------VNVHCHNDLGLALANAIMGIEAGATLVDATVNGLGERAGIVDLAQIITVL 234
+P ++VHCH+DLG+A+ N+I I+AGA ++ T+NG+GERAG L ++I +
Sbjct: 177 -KVPNIHKSTISVHCHDDLGMAVGNSISAIQAGARQIEGTINGIGERAGNTALEEVIMAI 235
Query: 235 YYHYGIKKYRLDL----LYRVSNLVSEITGISPQPNYPIVGENAFTHKAGLHVSAVLKDP 290
I ++ +YR S +VS I + N IVG NAF H +G+H VLK+
Sbjct: 236 KVREDILGVSTNINHKEIYRTSQIVSSICNMPIPSNKAIVGSNAFAHSSGIHQDGVLKNR 295
Query: 291 RFYEFL-PAEVFGRERTIYVDRYAGKDTIRYYLEKFGIRDH 330
YE + P + ++ + + +G+ +++Y+ + G +++
Sbjct: 296 ENYEIIDPISIGLKKVKLNLTSRSGRAAVKHYMNEMGYKEN 336
>gb|AAG31389.1| (AF197452) 2-isopropylmaltate synthase [Buchnera aphidicola]
Length = 503
Score = 163 bits (409), Expect = 2e-39
Identities = 104/345 (30%), Positives = 182/345 (52%), Gaps = 34/345 (9%)
Query: 9 EGEQTPGVNYTPEQRLEIAIALDEVGVDFIEIGHPAVSEDVFRGMKLIAEQGLNVELLAH 68
+GEQ + + E++L IA+ L++ GVD +E+G P S F+ ++ I+++ N ++ +
Sbjct: 1 DGEQALQASLSVEEKLXIALCLEKTGVDIMEVGFPISSPGDFKSVQTISKKIKNSQICSL 60
Query: 69 SRALIEDIDYV--LKTGVDWVGIFFCLS------EACLRKRFRITLDHALEKISRAIEYA 120
+R + +DID + D+ I L+ ++ LRK F +D A+ + RA+ Y
Sbjct: 61 ARCIEKDIDIAGEAMSVCDFFRIHIFLATSRLHMKSKLRKNFDEIIDMAIFSVKRALRYT 120
Query: 121 KDHGLKVRFTPEDTTRTEWANLKRAIRLAKELKVDRISVADTTGSTHPLRFYTLVKKIVN 180
D V+F+ ED +RT NL R + V I++ DT G + P ++K +
Sbjct: 121 DD----VQFSCEDASRTTIDNLCRIVEKLINSGVKTINIPDTVGYSIPNELSFIIKNLFQ 176
Query: 181 FGIP------VNVHCHNDLGLALANAIMGIEAGATLVDATVNGLGERAGIVDLAQIITVL 234
+P ++VHCH+DLG+A+ N+I I+AGA ++ T+NG+GERAG L ++I +
Sbjct: 177 -RVPNIDKAVISVHCHDDLGMAVGNSISAIQAGARQIEGTINGIGERAGNTALEEVIMAI 235
Query: 235 ---------YYHYGIKKYRLDLLYRVSNLVSEITGISPQPNYPIVGENAFTHKAGLHVSA 285
Y + K+ +YR S ++S I + N IVG NAF+H +G+H
Sbjct: 236 KVREKNLGVYTNINHKE-----IYRTSQMISRICNMPIPSNKAIVGSNAFSHSSGIHQDG 290
Query: 286 VLKDPRFYEFL-PAEVFGRERTIYVDRYAGKDTIRYYLEKFGIRD 329
VLK+ YE + P + + + + +G+ ++YY+ + G +D
Sbjct: 291 VLKNRENYEIIDPVSIGLKNVQLNLTSRSGRAAVKYYMNEMGYKD 335
>sp|Q07179|NIFV_RHOCA HOMOCITRATE SYNTHASE >gi|486695|pir||S34817 nifV protein -
Rhodobacter capsulatus >gi|297919|emb|CAA48488.1|
(X68444) nifV [Rhodobacter capsulatus]
Length = 382
Score = 163 bits (408), Expect = 3e-39
Identities = 115/331 (34%), Positives = 171/331 (50%), Gaps = 10/331 (3%)
Query: 4 DSTLREGEQTPGVNYTPEQRLEIAIALDEVGVDFIEIGHPAVSEDVFRGMKLIAEQGLNV 63
D+TLR+GEQT GV ++ ++ IA ALD GV IE+G A+ ++ + + +
Sbjct: 11 DTTLRDGEQTAGVAFSLAEKKAIARALDRAGVAEIEVGIAAMGWAEVAEIRAVVAEIAHA 70
Query: 64 ELLAHSRALIEDIDYVLKTGVDWVGIFFCLSEACLRKRFRITLDHALEKISRAIEYAKDH 123
+ R + D+D KTGV V S A L + R+ D L + + + A D
Sbjct: 71 TPVVWCRLRMHDLDMAQKTGVKRVHFAVPTSTAQLEGKLRVDRDWILRETAALVFCASDR 130
Query: 124 GLKVRFTPEDTTRTEWANLKRAIRLAKELKVDRISVADTTGSTHPLRFYTLVKKI-VNFG 182
GL+V ED +RT+ L R +A R +ADT G PL + LV ++
Sbjct: 131 GLQVSVGAEDASRTDPDFLIRLAEVAAAAGAIRFRIADTLGLLDPLGAFRLVAELSARIS 190
Query: 183 IPVNVHCHNDLGLALANAIMGIEAGATLVDATVNGLGERAGIVDLAQIITVLYYHYGIKK 242
+P+ +H HND G+A AN IM AGAT + TVNGLGERAG ++ L G
Sbjct: 191 LPIEMHAHNDFGMATANTIMAAHAGATHLSVTVNGLGERAGNAACEEVGAAL--EAGGID 248
Query: 243 YRLDL--LYRVSNLVSEITGISPQPNYPIVGEN-AFTHKAGLHVSAVLKDPRFYE---FL 296
LDL L +S +V++ +G + + PI G++ F H++G+HV A+LK YE
Sbjct: 249 TGLDLCALPELSAVVAKASGRAFRAQKPITGDDWLFAHESGIHVDAILKRADTYEDPRCA 308
Query: 297 PAEVFGRERTIYVDRYAGKDTIRYYLEKFGI 327
PA FGRER I + +++G +R L + G+
Sbjct: 309 PAR-FGRERQIVIGKHSGSAGLRAALLEAGL 338
>pir||S02508 homocitrate synthase (EC 4.1.3.21) - Klebsiella pneumoniae
>gi|43832|emb|CAA31676.1| (X13303) nifV protein (AA
1-380) [Klebsiella pneumoniae]
Length = 380
Score = 163 bits (408), Expect = 3e-39
Identities = 98/328 (29%), Positives = 166/328 (49%), Gaps = 2/328 (0%)
Query: 1 MVLDSTLREGEQTPGVNYTPEQRLEIAIALDEVGVDFIEIGHPAVSEDVFRGMKLIAEQG 60
++ D+TLR+GEQ+PGV + +++ IA AL G+ +E+G PA+ ++ ++L+ Q
Sbjct: 5 LINDTTLRDGEQSPGVAFRTSEKVAIAEALYAAGITAMEVGTPAMGDEEIARIQLVRRQL 64
Query: 61 LNVELLAHSRALIEDIDYVLKTGVDWVGIFFCLSEACLRKRFRITLDHALEKISRAIEYA 120
+ L+ R +I G+DWV I S+ + + R L LE+++ I A
Sbjct: 65 PDATLMTWCRMNALEIRQSADLGIDWVDISIPASDKLRQYKLREPLAVLLERLAMFIHLA 124
Query: 121 KDHGLKVRFTPEDTTRTEWANLKRAIRLAKELKVDRISVADTTGSTHPLRFYTLVKKIVN 180
GLKV ED +R L+ +A++ R+ ADT G P + + +
Sbjct: 125 HTLGLKVCIGCEDASRASGQTLRAIAEVAQQCAAARLRYADTVGLLDPFTTAAQISALRD 184
Query: 181 -FGIPVNVHCHNDLGLALANAIMGIEAGATLVDATVNGLGERAGIVDLAQIITVLYYHYG 239
+ + +H HNDLG+A AN + + AGAT V+ TV GLGERAG L + L G
Sbjct: 185 VWSGEIEMHAHNDLGMATANTLAAVSAGATSVNTTVLGLGERAGNAALETVALGLERCLG 244
Query: 240 IKK-YRLDLLYRVSNLVSEITGISPQPNYPIVGENAFTHKAGLHVSAVLKDPRFYEFLPA 298
++ L V+E + P P+VGE FTH++G+HV+A+L+ Y+ +
Sbjct: 245 VETGVHFSALPASCQRVAEAAQRAIDPQQPLVGELVFTHESGVHVAALLRHSESYQSIAP 304
Query: 299 EVFGRERTIYVDRYAGKDTIRYYLEKFG 326
+ GR + + +++G+ + ++ G
Sbjct: 305 SLMGRSYRLVLGKHSGRQAVNGVFDQMG 332
>gb|AAA22169.1| (M17349) nifV protein [Azotobacter vinelandii]
Length = 385
Score = 163 bits (408), Expect = 3e-39
Identities = 109/330 (33%), Positives = 170/330 (51%), Gaps = 10/330 (3%)
Query: 4 DSTLREGEQTPGVNYTPEQRLEIAIALDEVGVDFIEIGHPAVSEDVFRGMKLIAEQGLNV 63
D+TLR+GEQ+ GV + ++++ IA AL E+GV +EIG P++ E+ M IA GL+
Sbjct: 8 DTTLRDGEQSAGVAFNADEKIAIARALAELGVPELEIGIPSMGEEEREVMHAIAGLGLSS 67
Query: 64 ELLAHSRALIEDIDYVLKTGVDWVGIFFCLSEACLRKRFRITLDHALEKISRAIEYAKDH 123
LLA R D+ TGV V + +S+ L + D AL +++R + A+
Sbjct: 68 RLLAWCRLCDVDLAAARSTGVTMVDLSLPVSDLMLHHKLNRDRDWALREVARLVGEARMA 127
Query: 124 GLKVRFTPEDTTRTEWANLKRAIRLAKELKVDRISVADTTGSTHPL----RFYTLVKKIV 179
GL+V ED +R + + + +A+ + ADT G P RF L +++
Sbjct: 128 GLEVCLGCEDASRADLEFVVQVGEVAQAAGARPLRFADTVGVMEPFGMLDRFRFLSRRL- 186
Query: 180 NFGIPVNVHCHNDLGLALANAIMGIEAGATLVDATVNGLGERAGIVDLAQIITVLYYHYG 239
+ + VH H+D GLA AN + + GAT ++ TVNGLGERAG L + + L +G
Sbjct: 187 --DMELEVHAHDDFGLATANTLAAVMGGATHINTTVNGLGERAGNAALEECVLALKNLHG 244
Query: 240 IKKYRLDL--LYRVSNLVSEITGISPQPNYPIVGENAFTHKAGLHVSAVLKDPRFYEFLP 297
I +D + +S LV +G +VG FTH+AG+HV +LK R YE L
Sbjct: 245 IDT-GIDTRGIPAISALVERASGRQVAWQKSVVGAGVFTHEAGIHVDGLLKHRRNYEGLN 303
Query: 298 AEVFGRERTIYVDRYAGKDTIRYYLEKFGI 327
+ GR ++ + +++G +R GI
Sbjct: 304 PDELGRSHSLVLGKHSGAHMVRNTYRDLGI 333
>gb|AAG31392.1| (AF197453) 2-isopropylmaltate synthase [Buchnera aphidicola]
Length = 502
Score = 162 bits (406), Expect = 6e-39
Identities = 101/340 (29%), Positives = 179/340 (51%), Gaps = 24/340 (7%)
Query: 9 EGEQTPGVNYTPEQRLEIAIALDEVGVDFIEIGHPAVSEDVFRGMKLIAEQGLNVELLAH 68
+GEQ + + +++L+IA+ L++ VD +E+G P S F+ ++ I++ N + +
Sbjct: 1 DGEQALQASLSVKEKLQIALCLEKAKVDIMEVGFPISSPGDFKSVQTISKNIKNSRICSL 60
Query: 69 SRALIEDIDYV--LKTGVDWVGIFFCLS------EACLRKRFRITLDHALEKISRAIEYA 120
+R + +DID + D I L+ E+ LRK F +D A+ + +A+ Y
Sbjct: 61 ARCIEKDIDAAGEAMSVCDSFRIHLFLATSILHMESKLRKNFNEIIDMAVFSVKKALRYT 120
Query: 121 KDHGLKVRFTPEDTTRTEWANLKRAIRLAKELKVDRISVADTTGSTHPLRFYTLVKKIVN 180
D + F+ ED +R+ NL R + + V I++ DT G P F ++K +
Sbjct: 121 DD----IEFSCEDASRSTIDNLCRIVEVLINTGVKTINIPDTVGYAVPNEFSFIIKSLFE 176
Query: 181 FGIP------VNVHCHNDLGLALANAIMGIEAGATLVDATVNGLGERAGIVDLAQIITVL 234
+P ++VHCH+DLG+A+ N+I I+AGA ++ T+NG+GERAG L +II +
Sbjct: 177 -RVPNIHKSVISVHCHDDLGMAVGNSISAIQAGARQIEGTINGIGERAGNTALEEIIMAI 235
Query: 235 YYHYGIKKYRLDL----LYRVSNLVSEITGISPQPNYPIVGENAFTHKAGLHVSAVLKDP 290
+ ++ +YR S +VS I + N IVG NAF+H +G+H VLK+
Sbjct: 236 KVRENLLGVSTNINHKEIYRTSQIVSRICNMPIPSNKSIVGSNAFSHSSGIHQDGVLKNR 295
Query: 291 RFYEFL-PAEVFGRERTIYVDRYAGKDTIRYYLEKFGIRD 329
YE + P + ++ + + +G+ ++YY+ + G +D
Sbjct: 296 ENYEIMDPISIGVKKVKLNLTSRSGRAAVKYYMNQMGYKD 335
>sp|Q39891|LEU1_SOYBN PROBABLE 2-ISOPROPYLMALATE SYNTHASE (ALPHA-ISOPROPYLMALATE
SYNTHASE) (ALPHA-IPM SYNTHETASE) (LATE NODULIN 56)
(N-56) >gi|7447056|pir||T08590 2-isopropylmalate
synthase homolog - soybean >gi|532290|dbj|BAA07212.1|
(D38015) soybean late nodulin [Glycine max]
Length = 565
Score = 162 bits (405), Expect = 7e-39
Identities = 109/356 (30%), Positives = 176/356 (48%), Gaps = 34/356 (9%)
Query: 2 VLDSTLREGEQTPGVNYTPEQRLEIAIALDEVGVDFIEIGHPAVSEDVFRGMKLIAEQ-- 59
+LD+TLR+GEQ+PG T +++L+IA L ++GVD I+ G P+ S F +K+IA++
Sbjct: 35 ILDTTLRDGEQSPGATMTAKEKLDIARQLVKLGVDIIQPGFPSASNSDFMAVKMIAQEVG 94
Query: 60 ------GLNVELLAHSRALIEDIDYVLKTGVDWVGIFFCLSEAC----LRKRFRITLDHA 109
G + R + +DI + C S A + + R + D
Sbjct: 95 NAVDDDGYVPVIAGFCRCVEKDISTAWEAVKYAKRPRLCTSIATSPIHMEHKLRKSKDQV 154
Query: 110 LEKISRAIEYAKDHGLK-VRFTPEDTTRTEWANLKRAIRLAKELKVDRISVADTTGSTHP 168
++ +++A+ G ++F ED TR++ L + + E +++ADT G P
Sbjct: 155 IQIARDMVKFARSLGCNDIQFGAEDATRSDREFLYEILGVVIEAGATTVNIADTVGIVMP 214
Query: 169 LRFYTLVKKIVN-----FGIPVNVHCHNDLGLALANAIMGIEAGATLVDATVNGLGERAG 223
L L+ I + + ++ HCHNDLGLA AN I G GA ++ T+NG+GERAG
Sbjct: 215 LELGKLIVDIKDNTPGIANVIISTHCHNDLGLATANTIEGARTGARQLEVTINGIGERAG 274
Query: 224 IVDLAQIITVLYYHYGIKKYRLDLLY---------RVSNLVSEITGISPQPNYPIVGENA 274
L +++ L + L+ LY S +V E +G+ QP+ P+VG NA
Sbjct: 275 NASLEEVVMAL---ASKGDHALNGLYTRINTRHILETSKMVEEYSGMHLQPHKPLVGANA 331
Query: 275 FTHKAGLHVSAVLKDPRFYEFLPAEVFGRERT----IYVDRYAGKDTIRYYLEKFG 326
F H +G+H +LK YE + E G +RT I + + +G +R LE+ G
Sbjct: 332 FVHASGIHQDGMLKHKGTYETISPEEIGHKRTTRIGIVLGKLSGSQALRKRLEELG 387
>gb|AAG31926.1|AF200468_1 (AF200468) 2-isopropylmalate synthase [Buchnera aphidicola]
Length = 437
Score = 161 bits (404), Expect = 1e-38
Identities = 99/327 (30%), Positives = 174/327 (52%), Gaps = 24/327 (7%)
Query: 22 QRLEIAIALDEVGVDFIEIGHPAVSEDVFRGMKLIAEQGLNVELLAHSRALIEDIDYVLK 81
++L+IA++L+++GVD +E+G P S F+ ++ I++ N + + +R L +DID +
Sbjct: 1 EKLQIALSLEKIGVDIMEVGFPISSPGDFKSVQTISKNIKNSRICSLARCLEKDIDAAGE 60
Query: 82 TGVDW----VGIFFCLS----EACLRKRFRITLDHALEKISRAIEYAKDHGLKVRFTPED 133
+ IF S E+ LRK F ++ A+ + +A+ Y D V F+ ED
Sbjct: 61 AMSVCDNFRIHIFLATSTLHIESKLRKNFNEIIEMAIFSVKKALRYTND----VEFSCED 116
Query: 134 TTRTEWANLKRAIRLAKELKVDRISVADTTGSTHPLRFYTLVKKIVNFGIP------VNV 187
+RT NL R + + V I++ DT G + P ++K + +P ++V
Sbjct: 117 ASRTNIDNLCRIVEKLIKSGVKTINIPDTVGYSTPDELTFIIKNLFE-RVPNIHKSIISV 175
Query: 188 HCHNDLGLALANAIMGIEAGATLVDATVNGLGERAGIVDLAQIITVLYYHYGIKKYRLDL 247
HCH+DLG+A+ N+I I+AGA ++ T+NG+GERAG L ++I + I ++
Sbjct: 176 HCHDDLGMAVGNSIAAIQAGARQIEGTINGIGERAGNTALEEVIMAIKVRKNILGVSTNI 235
Query: 248 ----LYRVSNLVSEITGISPQPNYPIVGENAFTHKAGLHVSAVLKDPRFYEFLPAEVFGR 303
+YR S ++S I + N IVG NAF+H +G+H VLK+ YE + G
Sbjct: 236 NHKEIYRTSQMISRICNMPIPSNKAIVGSNAFSHSSGIHQDGVLKNRENYEIMDPRSIGL 295
Query: 304 ERT-IYVDRYAGKDTIRYYLEKFGIRD 329
++ + + +G+ ++YY+ + G +D
Sbjct: 296 KKVKLNLTSRSGRAAVKYYMSEMGYKD 322
>gb|AAG31386.1| (AF197451) 2-isopropylmaltate synthase [Buchnera aphidicola]
Length = 491
Score = 161 bits (403), Expect = 1e-38
Identities = 100/328 (30%), Positives = 175/328 (52%), Gaps = 24/328 (7%)
Query: 21 EQRLEIAIALDEVGVDFIEIGHPAVSEDVFRGMKLIAEQGLNVELLAHSRALIEDIDYVL 80
+++L+IA++L++ GVD +E+G P S F+ ++ I++ N + + +R L +DID
Sbjct: 2 KEKLQIALSLEKAGVDIMEVGFPISSPGDFKSVQTISKNIKNSRICSLARCLEKDIDAAG 61
Query: 81 KT----GVDWVGIFFCLS----EACLRKRFRITLDHALEKISRAIEYAKDHGLKVRFTPE 132
+ + IF S E+ LRK F +D A+ + +A+ Y D V F+ E
Sbjct: 62 EAMSVCDSFRIHIFLATSTLHMESKLRKNFNEIVDMAVFSVKKALRYTDD----VEFSCE 117
Query: 133 DTTRTEWANLKRAIRLAKELKVDRISVADTTGSTHPLRFYTLVKKIVNFGIP------VN 186
D +RT NL R + + V I++ DT G + P +++ + +P ++
Sbjct: 118 DASRTTIDNLCRIVEKLIKSGVKTINIPDTVGYSIPNELTCIIQNLFE-RVPNIHKSIIS 176
Query: 187 VHCHNDLGLALANAIMGIEAGATLVDATVNGLGERAGIVDLAQIITVLYYHYGIKKYRLD 246
VHCH+DLG+A+ N+I I+AGA ++ T+NG+GERAG L ++I + I +
Sbjct: 177 VHCHDDLGMAVGNSISAIQAGARQIEGTINGIGERAGNTALEEVIMAIKVRKDILGVSTN 236
Query: 247 L----LYRVSNLVSEITGISPQPNYPIVGENAFTHKAGLHVSAVLKDPRFYEFLPAEVFG 302
+ +YR S ++S I + N IVG NAF+H +G+H VLK+ YE + + G
Sbjct: 237 INHKEIYRTSQIISRICNMPIPSNKAIVGSNAFSHSSGIHQDGVLKNRENYEIMDPKSIG 296
Query: 303 RERT-IYVDRYAGKDTIRYYLEKFGIRD 329
++ + + +G+ +RYY+ + G +D
Sbjct: 297 LKKVKLNLTSRSGRAAVRYYMNEMGYKD 324
>dbj|BAB08874.1| (AB026660) 2-isopropylmalate synthase-like; homocitrate
synthase-like [Arabidopsis thaliana]
Length = 506
Score = 161 bits (402), Expect = 2e-38
Identities = 121/380 (31%), Positives = 192/380 (49%), Gaps = 33/380 (8%)
Query: 2 VLDSTLREGEQTPGVNYTPEQRLEIAIALDEVGVDFIEIGHPAVSEDVFRGMKLIA---- 57
V D+TLR+GEQ+PG + TP Q+LEIA L ++ VD +E+G P SE+ +K IA
Sbjct: 87 VFDTTLRDGEQSPGGSLTPPQKLEIARQLAKLRVDIMEVGFPGSSEEELETIKTIAKTVG 146
Query: 58 -----EQGLNVELLAHSRALIEDIDYVLKT----GVDWVGIFFCLSEACLRKRFRITLDH 108
E G + A +R DI+ + + +F S+ ++ + + T +
Sbjct: 147 NEVDEETGYVPVICAIARCKHRDIEATWEALKYAKRPRILVFTSTSDIHMKYKLKKTQEE 206
Query: 109 ALEKISRAIEYAKDHGLK-VRFTPEDTTRTEWANLKRAIRLAKELKVDRISVADTTGSTH 167
+E +I +AK G ++F ED R++ L + + A + V +++ DT G
Sbjct: 207 VIEMAVSSIRFAKSLGFNDIQFGCEDGGRSDKDFLCKILGEAIKAGVTVVTIGDTVGINM 266
Query: 168 PLRFYTLVK--KIVNFGIP---VNVHCHNDLGLALANAIMGIEAGATLVDATVNGLGERA 222
P + LV K GI V VHCHNDLGLA AN+I GI AGA V+ T+NG+GER+
Sbjct: 267 PHEYGELVTYLKANTPGIDDVVVAVHCHNDLGLATANSIAGIRAGARQVEVTINGIGERS 326
Query: 223 GIVDLAQIITVL-----YYHYGI-KKYRLDLLYRVSNLVSEITGISPQPNYPIVGENAFT 276
G L +++ L Y G+ K + S +V E TG+ Q + PIVG N F
Sbjct: 327 GNASLEEVVMALKCRGAYVINGVYTKIDTRQIMATSKMVQEYTGLYVQAHKPIVGANCFV 386
Query: 277 HKAGLHVSAVLKDPRFYEFLPAEVFG----RERTIYVDRYAGKDTIRYYLEKFG--IRDH 330
H++G+H +LK+ YE L E G + + + + +G+ ++ L++ G + D
Sbjct: 387 HESGIHQDGILKNRSTYEILSPEDIGIVKSQNSGLVLGKLSGRHAVKDRLKELGYELDDE 446
Query: 331 GI--VTSLLRKVKSSREPFT 348
+ V SL R + +++ T
Sbjct: 447 KLNAVFSLFRDLTKNKKRIT 466
>pir||A82634 2-isopropylmalate synthase XF1818 [imported] - Xylella fastidiosa
(strain 9a5c) >gi|9106897|gb|AAF84624.1|AE004003_3
(AE004003) 2-isopropylmalate synthase [Xylella
fastidiosa]
Length = 519
Score = 160 bits (400), Expect = 3e-38
Identities = 107/341 (31%), Positives = 169/341 (49%), Gaps = 18/341 (5%)
Query: 2 VLDSTLREGEQTPGVNYTPEQRLEIAIALDEVGVDFIEIGHPAVSEDVFRGMKLIAEQGL 61
+ D+TLR+GEQ+PG + +Q+L +A ALD +GVD IE G PA S+ + M LIA +
Sbjct: 14 IFDTTLRDGEQSPGCSMPAQQKLVMARALDALGVDIIETGFPASSQSDYEAMTLIARELR 73
Query: 62 NVELLAHSRALIEDIDYVLK----TGVDWVGIFFCLSEACLRKRFRITLDHALEKISRAI 117
L SR L DI+ + + +F S + R++ + LE + + +
Sbjct: 74 RPTLAVLSRCLQADIETSARALESATKPRLHVFLSTSPLHREHKLRMSKEQVLESVHKHV 133
Query: 118 EYAKDHGLKVRFTPEDTTRTEWANLKRAIRLAKELKVDRISVADTTGSTHPLRFYTLVKK 177
++ V F+ ED TRTE L R+A I++ DT G + P + +
Sbjct: 134 SLSRTLIDDVEFSAEDATRTEEDFLIEVTRVAIAAGATTINLPDTVGFSTPEEIRNMFTR 193
Query: 178 IV-----NFGIPVNVHCHNDLGLALANAIMGIEAGATLVDATVNGLGERAGIVDLAQIIT 232
I+ + + HCH+DLGLA+AN++ IE GA ++ T+NG+GERAG L ++
Sbjct: 194 IIANVEGANKVIFSAHCHDDLGLAVANSLAAIEGGARQIECTINGIGERAGNCALEELTM 253
Query: 233 VLYYHYGIKKYRLDLLYRVSNLVS------EITGISPQPNYPIVGENAFTHKAGLHVSAV 286
VL Y +D S +VS + G+ Q N +VG NAF H++G+H +
Sbjct: 254 VLKVRNAF--YNIDTSIHTSRIVSTSQLLQRLVGMPVQRNKAVVGANAFAHESGIHQHGM 311
Query: 287 LKDPRFYEFL-PAEVFGRERTIYVDRYAGKDTIRYYLEKFG 326
L+ YE + P EV + + R++G+ + L G
Sbjct: 312 LRHRGTYEIMRPQEVGWVCSHMVLGRHSGRAAVEQRLRALG 352
>sp|O04973|LU1A_LYCPN 2-ISOPROPYLMALATE SYNTHASE A (ALPHA-ISOPROPYLMALATE SYNTHASE A)
(ALPHA-IPM SYNTHETASE A) >gi|2213882|gb|AAB61598.1|
(AF004165) 2-isopropylmalate synthase [Lycopersicon
pennellii]
Length = 589
Score = 159 bits (399), Expect = 4e-38
Identities = 112/352 (31%), Positives = 175/352 (48%), Gaps = 36/352 (10%)
Query: 2 VLDSTLREGEQTPGVNYTPEQRLEIAIALDEVGVDFIEIGHPAVSEDVFRGMKLIAEQ-G 60
+ D+TLR+GEQ+PG T +++L++A L ++GVD IE G PA SE F +KLIAE+ G
Sbjct: 50 IFDTTLRDGEQSPGATMTTKEKLDVARQLAKLGVDIIEAGFPASSEADFESVKLIAEEIG 109
Query: 61 LNVE-------LLAHSRALIEDID-------YVLKTGVDWVGIFFCLSEACLRKRFRITL 106
N + + SR DID Y K V F SE ++ + +++
Sbjct: 110 NNTDENGFVPVICGLSRCNKSDIDKAWEAVKYAKKPRVH---TFIATSEIHMKYKLKMSR 166
Query: 107 DHALEKISRAIEYAKDHGLK-VRFTPEDTTRTEWANLKRAIRLAKELKVDRISVADTTGS 165
+ +EK + YA+ G + V F+PED R++ L + + +++ DT G
Sbjct: 167 EQVVEKARSMVAYARSLGCEDVEFSPEDAGRSDREFLYDILGEVIKAGATTLNIPDTVGY 226
Query: 166 THPLRFYTLVKKIVN-----FGIPVNVHCHNDLGLALANAIMGIEAGATLVDATVNGLGE 220
T P F L+ I + ++ HC NDLGL+ AN + G AGA ++ T+NG+GE
Sbjct: 227 TVPSEFGQLITDIKANTPGIENVIISTHCQNDLGLSTANTLAGACAGARQLEVTINGIGE 286
Query: 221 RAGIVDLAQIITVLY---------YHYGIKKYRLDLLYRVSNLVSEITGISPQPNYPIVG 271
RAG L +++ L + GI + S +V E +G+ QP+ IVG
Sbjct: 287 RAGNASLEEVVMALKCRGEQVLGGLYTGINTQH---IVPSSKMVEEYSGLQVQPHKAIVG 343
Query: 272 ENAFTHKAGLHVSAVLKDPRFYEFLPAEVFGRERTIYVDRYAGKDTIRYYLE 323
NAF H++G+H +LK YE + + G R+ GK + R+ L+
Sbjct: 344 ANAFAHESGIHQDGMLKHKDTYEIISPDDVGLSRSNEAGIVLGKLSGRHALK 395
>sp|P48575|LEU1_ANASP 2-ISOPROPYLMALATE SYNTHASE (ALPHA-ISOPROPYLMALATE SYNTHASE)
(ALPHA-IPM SYNTHETASE) >gi|1084180|pir||S52294
2-isopropylmalate synthase (EC 4.1.3.12) - Anabaena sp.
(PCC 7120) >gi|662867|emb|CAA87005.1| (Z46907)
alpha-isopropylmalate synthase [Anabaena PCC7120]
Length = 531
Score = 159 bits (398), Expect = 5e-38
Identities = 107/355 (30%), Positives = 180/355 (50%), Gaps = 30/355 (8%)
Query: 1 MVLDSTLREGEQTPGVNYTPEQRLEIAIALDEVGVDFIEIGHPAVSEDVFRGMKLIAEQ- 59
++ D+TLR+GEQ PG +++L IA L +GVD IE G S F + IA+
Sbjct: 9 IIFDTTLRDGEQCPGATLNIDEKLAIAKQLARLGVDIIEAGFAFASPGDFEAVHKIAQTV 68
Query: 60 --GLNVELLAHSRALIEDI----DYVLKTGVDWVGIFFCLSEACLRKRFRITLDHALEKI 113
+ + +RA +DI + + + F S+ L+ + + T +
Sbjct: 69 GTQSGPVICSLARARHDDIKAAAEAIKPAAKGRIHTFIATSDIHLQYKLKKTRPEVIAIA 128
Query: 114 SRAIEYAKDHGLKVRFTPEDTTRTEWANLKRAIRLAKELKVDRISVADTTGSTHPLRFYT 173
+ YAK V F+PED R++ L + + A I++ DT G T P F
Sbjct: 129 EEMVAYAKSFTDDVEFSPEDAGRSDPEFLYQVLERAIAAGATTINIPDTVGYTTPSEFGA 188
Query: 174 LVKKIVNFGIP------VNVHCHNDLGLALANAIMGIEAGATLVDATVNGLGERAGIVDL 227
++K I +P ++VH HNDLGLA+AN + ++ GA ++ T+NG+GERAG L
Sbjct: 189 IIKGIKE-NVPNIDQAIISVHGHNDLGLAVANFLEAVKNGARQLECTINGIGERAGNAAL 247
Query: 228 AQIITVL-----YYHYGIKKY--------RLDL--LYRVSNLVSEITGISPQPNYPIVGE 272
+++ + Y++ + ++ +D +Y+ S LVS +TG+ QPN IVG
Sbjct: 248 EELVMAMHVRRQYFNPFLGRHPDSEEALTNIDTKQIYKTSRLVSNLTGMLVQPNKAIVGA 307
Query: 273 NAFTHKAGLHVSAVLKDPRFYEFLPAEVFG-RERTIYVDRYAGKDTIRYYLEKFG 326
NAF H++G+H VLK+ YE + A++ G + I + +++G++ R L++ G
Sbjct: 308 NAFAHESGIHQDGVLKNKLTYEIMDAQLIGLTDNQIVLGKHSGRNAFRTRLKELG 362
>gb|AAF26002.1|AC013354_21 (AC013354) F15H18.3 [Arabidopsis thaliana]
Length = 675
Score = 159 bits (398), Expect = 5e-38
Identities = 112/346 (32%), Positives = 171/346 (49%), Gaps = 24/346 (6%)
Query: 2 VLDSTLREGEQTPGVNYTPEQRLEIAIALDEVGVDFIEIGHPAVSEDVFRGMKLIA---- 57
V D+TLR+GEQ+PG T +++L+IA L ++GVD IE G PA S+D F +K IA
Sbjct: 91 VFDTTLRDGEQSPGATLTSKEKLDIARQLAKLGVDIIEAGFPAASKDDFEAVKTIAETVG 150
Query: 58 ----EQGLNVELLAHSRALIEDI----DYVLKTGVDWVGIFFCLSEACLRKRFRITLDHA 109
E G + SR +DI D V + F S+ L + + T
Sbjct: 151 NTVDENGYVPVICGLSRCNKKDIERAWDAVKYAKRPRIHTFIATSDIHLEYKLKKTKAEV 210
Query: 110 LEKISRAIEYAKDHGLK-VRFTPEDTTRTEWANLKRAIRLAKELKVDRISVADTTGSTHP 168
+E + +A+ G + V F+PED R+E L + + +++ DT G T P
Sbjct: 211 IEIARSMVRFARSLGCEDVEFSPEDAGRSEREYLYEILGEVIKAGATTLNIPDTVGITLP 270
Query: 169 LRFYTLVKKIVN-----FGIPVNVHCHNDLGLALANAIMGIEAGATLVDATVNGLGERAG 223
F L+ + + ++ HC NDLGL+ AN + G AGA ++ T+NG+GERAG
Sbjct: 271 SEFGQLITDLKANTPGIENVVISTHCQNDLGLSTANTLSGAHAGARQMEVTINGIGERAG 330
Query: 224 IVDLAQIITVLY----YHYGIKKYRLDLLYRV--SNLVSEITGISPQPNYPIVGENAFTH 277
L +++ + + G +D + V S +V E TG+ QP+ IVG NAF H
Sbjct: 331 NASLEEVVMAIKCRGDHVLGGLFTGIDTRHIVMTSKMVEEYTGMQTQPHKAIVGANAFAH 390
Query: 278 KAGLHVSAVLKDPRFYEFLPAEVFGRERTIYVDRYAGKDTIRYYLE 323
++G+H +LK YE + E G ER+ GK + R+ L+
Sbjct: 391 ESGIHQDGMLKHKGTYEIICPEEIGLERSNDAGIVLGKLSGRHALK 436
>sp|P05345|NIFV_KLEPN HOMOCITRATE SYNTHASE >gi|479601|pir||S34848 homocitrate synthase
(EC 4.1.3.21) - Klebsiella pneumoniae
>gi|43881|emb|CAA31119.1| (X12600) nifV gene product (AA
1 - 381) [Klebsiella pneumoniae]
Length = 381
Score = 159 bits (397), Expect = 6e-38
Identities = 98/329 (29%), Positives = 167/329 (49%), Gaps = 3/329 (0%)
Query: 1 MVLDSTLREGEQTPGVNYTPEQRLEIAIALDEVGVDFIEIGHPAVSEDVFRGMKLIAEQG 60
++ D+TLR+GEQ+PGV + +++ IA AL G+ +E+G PA+ ++ ++L+ Q
Sbjct: 5 LINDTTLRDGEQSPGVAFRTSEKVAIAEALYAAGITAMEVGTPAMGDEEIARIQLVRRQL 64
Query: 61 LNVELLAHSRALIEDIDYVLKTGVDWVGIFFCLSEACLRKRFRITLDHALEKISRAIEYA 120
+ L+ R +I G+DWV I S+ + + R L LE+++ I A
Sbjct: 65 PDATLMTWCRMNALEIRQSADLGIDWVDISIPASDKLRQYKLREPLAVLLERLAMFIHLA 124
Query: 121 KDHGLKVRFTPEDTTRTEWANLKRAIRLAKELKVDRISVADTTGSTHPLRFYTLVKKIVN 180
GLKV ED +R L+ +A+ R+ ADT G P + + +
Sbjct: 125 HTLGLKVCIGCEDASRASGQTLRAIAEVAQNAPAARLRYADTVGLLDPFTTAAQISALRD 184
Query: 181 -FGIPVNVHCHNDLGLALANAIMGIEAGATLVDATVNGLGERAGIVDLAQIITV-LYYHY 238
+ + +H HNDLG+A AN + + AGAT V+ TV GLGERAG + + L
Sbjct: 185 VWSGEIEMHAHNDLGMATANTLAAVSAGATSVNTTVLGLGERAGNAAAWKPSALGLERCL 244
Query: 239 GIKK-YRLDLLYRVSNLVSEITGISPQPNYPIVGENAFTHKAGLHVSAVLKDPRFYEFLP 297
G++ L + V+E + P P+VGE FTH++G+HV+A+L+D Y+ +
Sbjct: 245 GVETGVHFSALPALCQRVAEAAQRAIDPQQPLVGELVFTHESGVHVAALLRDSESYQSIA 304
Query: 298 AEVFGRERTIYVDRYAGKDTIRYYLEKFG 326
+ GR + + +++G+ + ++ G
Sbjct: 305 PSLMGRSYRLVLGKHSGRQAVNGVFDQMG 333
>sp|Q01181|NIFV_RHOSH HOMOCITRATE SYNTHASE >gi|282178|pir||D41880 isopropylmalate
synthetase homolog NIfV - Rhodobacter sphaeroides
>gi|151969|gb|AAA26138.1| (M86823) nifV [Rhodobacter
sphaeroides]
Length = 391
Score = 159 bits (397), Expect = 6e-38
Identities = 107/327 (32%), Positives = 160/327 (48%), Gaps = 3/327 (0%)
Query: 4 DSTLREGEQTPGVNYTPEQRLEIAIALDEVGVDFIEIGHPAVSEDVFRGMKLIAEQGLNV 63
D+TLR+GEQT GV +T ++ IA AL GV +E+G PA+ E+ ++ +A
Sbjct: 23 DTTLRDGEQTAGVAFTRAEKRAIAEALQAAGVAEVEVGVPAMGEEERADIRAVAAVLKTA 82
Query: 64 ELLAHSRALIEDIDYVLKTGVDWVGIFFCLSEACLRKRFRITLDHALEKISRAIEYAKDH 123
+ R ED+ +TGV + I +SE + + +K+ + + A
Sbjct: 83 APVVWCRLRAEDLAAAQRTGVVRLHIGVPVSERQISAKLGKDAAWVRDKVEKLVRAASWA 142
Query: 124 GLKVRFTPEDTTRTEWANLKRAIRLAKELKVDRISVADTTGSTHPLRFYTLVKKIV-NFG 182
G KV ED +R + L +A E R ++DT G P + LV ++V
Sbjct: 143 GHKVSVGAEDASRADPFFLAEIAHVAAEAGAIRFRISDTLGVLDPFAAHELVGRVVTRCP 202
Query: 183 IPVNVHCHNDLGLALANAIMGIEAGATLVDATVNGLGERAGIVDLAQIITVLYYHYGIKK 242
+PV H HNDLG+A AN++ AGA+ + TVNGLGERAG L ++ L
Sbjct: 203 LPVEFHGHNDLGMATANSLAAARAGASHLSVTVNGLGERAGNAALEEVAAALEAAGRATG 262
Query: 243 YRLDLLYRVSNLVSEITGISPQPNYPIVGENAFTHKAGLHVSAVLKDPRFYEF--LPAEV 300
L L +S LV+ +G P PIVGE FTH+ G+HV ++KD YE L E
Sbjct: 263 VALGQLCALSELVARASGRPLSPQKPIVGEGVFTHECGIHVDGLMKDRATYESADLRPER 322
Query: 301 FGRERTIYVDRYAGKDTIRYYLEKFGI 327
FGR I + +++ + L + G+
Sbjct: 323 FGRSHRIAIGKHSSAAGLARALAEAGL 349
>pir||S37297 nifV protein - Klebsiella pneumoniae >gi|149345|gb|AAA25157.1|
(M17350) nifV-encoded protein [Klebsiella pneumoniae]
Length = 381
Score = 158 bits (396), Expect = 8e-38
Identities = 98/329 (29%), Positives = 167/329 (49%), Gaps = 3/329 (0%)
Query: 1 MVLDSTLREGEQTPGVNYTPEQRLEIAIALDEVGVDFIEIGHPAVSEDVFRGMKLIAEQG 60
++ D+TLR+GEQ+PGV + +++ IA AL G+ +E+G PA+ ++ ++L+ Q
Sbjct: 5 LINDTTLRDGEQSPGVAFRTSEKVAIAEALYAAGITAMEVGTPAMGDEEIARIQLVRRQL 64
Query: 61 LNVELLAHSRALIEDIDYVLKTGVDWVGIFFCLSEACLRKRFRITLDHALEKISRAIEYA 120
+ L+ R +I G+DWV I S+ + + R L LE+++ I A
Sbjct: 65 PDATLMTWCRMNALEIRQSADLGIDWVDISIPASDKLPQYKLREPLAVLLERLAMFIHLA 124
Query: 121 KDHGLKVRFTPEDTTRTEWANLKRAIRLAKELKVDRISVADTTGSTHPLRFYTLVKKIVN 180
GLKV ED +R L+ +A+ R+ ADT G P + + +
Sbjct: 125 HTLGLKVCIGCEDASRASGQTLRAIAEVAQNAPAARLRYADTVGLLDPFTTAAQISALRD 184
Query: 181 -FGIPVNVHCHNDLGLALANAIMGIEAGATLVDATVNGLGERAGIVDLAQIITV-LYYHY 238
+ + +H HNDLG+A AN + + AGAT V+ TV GLGERAG + + L
Sbjct: 185 VWSGEIEMHAHNDLGMATANTLAAVSAGATSVNTTVLGLGERAGNAAAWKPSALGLERCL 244
Query: 239 GIKK-YRLDLLYRVSNLVSEITGISPQPNYPIVGENAFTHKAGLHVSAVLKDPRFYEFLP 297
G++ L + V+E + P P+VGE FTH++G+HV+A+L+D Y+ +
Sbjct: 245 GVETGVHFSALPALCQRVAEAAQRAIDPQQPLVGELVFTHESGVHVAALLRDSESYQSIA 304
Query: 298 AEVFGRERTIYVDRYAGKDTIRYYLEKFG 326
+ GR + + +++G+ + ++ G
Sbjct: 305 PSLMGRSYRLVLGKHSGRQAVNGVFDQMG 333
>sp|O66682|LY41_AQUAE PUTATIVE LYASE AQ_356 >gi|7447064|pir||F70331 2-isopropylmalate
synthase - Aquifex aeolicus >gi|2983027|gb|AAC06637.1|
(AE000685) 2-isopropylmalate synthase [Aquifex aeolicus]
Length = 528
Score = 158 bits (396), Expect = 8e-38
Identities = 116/343 (33%), Positives = 175/343 (50%), Gaps = 17/343 (4%)
Query: 2 VLDSTLREGEQTPGVNYTPEQRLEIAIALDEVGVDFIEIGHP-AVSEDVFRGMKLIAEQG 60
+ D+TLR+G Q GV+++ E ++ IA LD+ G+ +IE G P A +D K
Sbjct: 7 IYDTTLRDGSQMEGVSFSLEDKIRIAEKLDDFGIHYIEGGWPYANPKDNLFFQKAKKMNF 66
Query: 61 LNVELLAH------SRALIED--IDYVLKTGVDWVGIFFCLSEACLRKRFRITLDHALEK 112
N +L A ++ + ED ++ ++K V IF + + + TL+ L
Sbjct: 67 KNAKLTAFGSTRRPNKKVSEDPQVESLIKAETPVVTIFGKSWDLHVTDALKTTLEENLNM 126
Query: 113 ISRAIEYAKDHGLKVRFTPEDTTRTEWANLKRAIR-LAKELK--VDRISVADTTGSTHPL 169
I +EY K + +V F E +N + A++ L LK D + + DT G T P
Sbjct: 127 IYETVEYLKRYVDEVIFDAEHFFDGYKSNPEYALQVLEAALKGGADWVVLCDTNGGTLPH 186
Query: 170 RFYTLVKKIVNFGIPVNV--HCHNDLGLALANAIMGIEAGATLVDATVNGLGERAGIVDL 227
Y + KK+ NV H HND A+AN++M + AGA V T+NG+GER G +L
Sbjct: 187 EIYEITKKVKERFKDANVGIHAHNDSETAVANSLMAVLAGARQVHGTINGIGERTGNANL 246
Query: 228 AQIITVLYYHYG---IKKYRLDLLYRVSNLVSEITGISPQPNYPIVGENAFTHKAGLHVS 284
II L G I + L L ++N V+EI + N P VGE+AF HK G+H S
Sbjct: 247 CSIIPNLQLKLGFDVIPQENLKKLTELANFVAEIINMPLPRNMPYVGESAFAHKGGVHAS 306
Query: 285 AVLKDPRFYEFLPAEVFGRERTIYVDRYAGKDTIRYYLEKFGI 327
AVLK+ + YE + E+ G +R I V AG+ + + L++FGI
Sbjct: 307 AVLKNAKTYEHINPELVGNKRKITVSDLAGRSNLVHKLKEFGI 349
>sp|Q47884|NIFV_FRAAL HOMOCITRATE SYNTHASE >gi|1256029|gb|AAA96261.1| (L41344)
homocitrate synthase [Frankia alni]
Length = 351
Score = 157 bits (394), Expect = 1e-37
Identities = 106/329 (32%), Positives = 171/329 (51%), Gaps = 10/329 (3%)
Query: 4 DSTLREGEQTPGVNYTPEQRLEIAIALDEVGVDFIEIGHPAVSEDVFRGMKLIAEQGLNV 63
D+TLR+GEQ PGV +T ++L IA ALD +GV IE G PA+ ++ I +
Sbjct: 27 DTTLRDGEQAPGVAFTAAEKLAIAAALDAIGVHQIEAGIPAMGVTERDVLREILATDPHA 86
Query: 64 ELLAHSRALIEDIDYVLKTGVDWVGIFFCLSEACLRKRFRITLDHALEKISRAIEYAKDH 123
+++ RA D++ G+ + +S+ L+ + A ++ + A D
Sbjct: 87 DIVGWCRADHRDVEAAASCGLVTAHLTIPVSDLHLKSKLGRDRAWARLRVRDCVADATDR 146
Query: 124 GLKVRFTPEDTTRTEWANLKRAIRLAKELKVDRISVADTTGSTHPLRFYTLVKKIVN-FG 182
G++V ED +R + A + +EL V R+ ADT G P+ + + ++V
Sbjct: 147 GMRVSVGFEDASRADDAFVTDLAGELRELGVTRLRWADTVGLLDPVSAHDRLGRLVRAVP 206
Query: 183 IPVNVHCHNDLGLALANAIMGIEAGATLVDATVNGLGERAGIVDLAQIITVLYYHYGIKK 242
P +H H+D GLA AN I ++AG T V TV GLGERAG + ++ L + + K
Sbjct: 207 GPWEIHAHDDFGLATANTIAAVQAGFTWVSTTVLGLGERAGNAPIEEVAMALRH---LLK 263
Query: 243 YRLDL----LYRVSNLVSEITGISPQPNYPIVGENAFTHKAGLHVSAVLKDPRFYE-FLP 297
+DL ++ LVS +VGE+ F H++G+HV +L+ P YE F P
Sbjct: 264 LPVDLDTTSFRSLARLVSRAARRPLPAGKAVVGESVFAHESGIHVHGILRHPATYEPFDP 323
Query: 298 AEVFGRERTIYVDRYAGKDTIRYYLEKFG 326
AEV GR R + + +++G+ ++RY LE++G
Sbjct: 324 AEVGGRRR-LAIGKHSGRASVRYALEQYG 351
>sp|P74269|LY41_SYNY3 PUTATIVE LYASE SLL1564 >gi|7447061|pir||S75904 hypothetical protein
- Synechocystis sp. (strain PCC 6803)
>gi|1653449|dbj|BAA18363.1| (D90913)
alpha-isopropylmalate synthase [Synechocystis sp.]
Length = 547
Score = 156 bits (390), Expect = 4e-37
Identities = 111/348 (31%), Positives = 172/348 (48%), Gaps = 24/348 (6%)
Query: 4 DSTLREGEQTPGVNYTPEQRLEIAIALDEVGVDFIEIGHPAVS-EDVFRGMKLIAEQGLN 62
D+TLR+G Q G++ + +L IA LD++G+ FIE G P + +DV +L E
Sbjct: 12 DTTLRDGAQREGISLSLTDKLTIARRLDQLGIPFIEGGWPGANPKDVQFFWQLQEEPLEQ 71
Query: 63 VELLAHS------RALIED--IDYVLKTGVDWVGIFFCLSEACLRKRFRITLDHALEKIS 114
E++A +A+ D + +L G WV IF + + + + +L L IS
Sbjct: 72 AEIVAFCSTRRPHKAVETDKMLQAILSAGTRWVTIFGKSWDLHVLEGLQTSLAENLAMIS 131
Query: 115 RAIEYAKDHGLKVRFTPE---DTTRTEWANLKRAIRLAKELKVDRISVADTTGSTHPLRF 171
I Y + G +V + E D R + A++ + + + DT G T P +
Sbjct: 132 DTIAYLRSQGRRVIYDAEHWFDGYRANPDYALATLATAQQAGAEWLVMCDTNGGTLPGQI 191
Query: 172 YTLVKKIV-NFGIP--------VNVHCHNDLGLALANAIMGIEAGATLVDATVNGLGERA 222
+ K+ + G+ + +H HND G A+AN+++ +EAGAT+V T+NG GER
Sbjct: 192 SEITTKVRRSLGLDGQSDRQPQLGIHAHNDSGTAVANSLLAVEAGATMVQGTINGYGERC 251
Query: 223 GIVDLAQIITVLYYHYG---IKKYRLDLLYRVSNLVSEITGISPQPNYPIVGENAFTHKA 279
G +L +I L I+ +L L S L+SEI ++P + P VG +AF HK
Sbjct: 252 GNANLCTLIPNLQLKLDYDCIEPEKLAHLTSTSRLISEIVNLAPDDHAPFVGRSAFAHKG 311
Query: 280 GLHVSAVLKDPRFYEFLPAEVFGRERTIYVDRYAGKDTIRYYLEKFGI 327
G+HVSAV ++P YE + + G ER I V AG + E FGI
Sbjct: 312 GIHVSAVQRNPFTYEHIAPNLVGNERRIVVSEQAGLSNVLSKAELFGI 359
>sp|O86511|LY41_STRCO PUTATIVE LYASE SC1C2.10 >gi|7480336|pir||T29059 probable
2-isopropylmalate synthase (EC 4.1.3.12) - Streptomyces
coelicolor >gi|3355677|emb|CAA19977.1| (AL031124)
putative lyase [Streptomyces coelicolor A3(2)]
Length = 534
Score = 155 bits (388), Expect = 7e-37
Identities = 107/362 (29%), Positives = 173/362 (47%), Gaps = 24/362 (6%)
Query: 2 VLDSTLREGEQTPGVNYTPEQRLEIAIALDEVGVDFIEIGHPAVS------------EDV 49
V D+TLR+G Q G+N T +L IA LD+ GV FIE G P + E
Sbjct: 13 VFDTTLRDGAQREGINLTVADKLAIARHLDDFGVGFIEGGWPGANPRDTEFFARARQEID 72
Query: 50 FRGMKLIAEQGLNVELLAHSRALIEDIDYVLKTGVDWVGIFFCLSEACLRKRFRITLDHA 109
F+ +L+A + + A + +L +G + + + + R TLD
Sbjct: 73 FKHAQLVAFG--STRRAGANAAEDHQVKALLDSGAQVITLVAKSHDRHVELALRTTLDEN 130
Query: 110 LEKISRAIEYAKDHGLKVRFTPE---DTTRTEWANLKRAIRLAKELKVDRISVADTTGST 166
L ++ + + K G +V E D R K +R A E D + + DT G
Sbjct: 131 LAMVADTVSHLKAQGRRVFVDCEHFFDGYRANPEYAKSVVRTASEAGADVVVLCDTNGGM 190
Query: 167 HPLRFYTLVKKIV-NFGIPVNVHCHNDLGLALANAIMGIEAGATLVDATVNGLGERAGIV 225
P + +V ++ + G + +H +D G A+AN + ++AGAT V T NG GER G
Sbjct: 191 LPAQIQAVVATVLADTGARLGIHAQDDTGCAVANTLAAVDAGATHVQCTANGYGERVGNA 250
Query: 226 DLAQIITVLYYHYG---IKKYRLDLLYRVSNLVSEITGISPQPNYPIVGENAFTHKAGLH 282
+L ++ L YG + + RL + R+S+ ++E+ ++P + P VG +AF HKAGLH
Sbjct: 251 NLFPVVAALELKYGKQVLPEGRLREMTRISHAIAEVVNLTPSTHQPYVGVSAFAHKAGLH 310
Query: 283 VSAVLKDPRFYEFLPAEVFGRERTIYVDRYAGKDTIRYYLEKFGI---RDHGIVTSLLRK 339
SA+ DP Y+ + E+ G + V AG+ +I ++ GI D +V ++ +
Sbjct: 311 ASAIKVDPDLYQHIDPELVGNTMRMLVSDMAGRASIELKGKELGIDLGGDRELVGRVVER 370
Query: 340 VK 341
VK
Sbjct: 371 VK 372
>sp|Q44290|NIFV_ANASP HOMOCITRATE SYNTHASE >gi|1487879|emb|CAA68174.1| (X99902)
homocitrate synthase [Anabaena sp.]
Length = 379
Score = 154 bits (386), Expect = 1e-36
Identities = 116/374 (31%), Positives = 187/374 (49%), Gaps = 23/374 (6%)
Query: 1 MVLDSTLREGEQTPGVNYTPEQRLEIAIALDEVGVDFIEIGHPAVSEDVFRGMKLIAEQG 60
++ D+TLR+GEQ GV +T E+++ IA LD +GV +E+G PA+ E+ R + I+ G
Sbjct: 5 LINDTTLRDGEQAAGVVFTLEEKVAIAKFLDTIGVPELEVGIPAMGEEEMRAICAISNLG 64
Query: 61 LNVELLAHSRALIEDIDYVLKTGVDWVGIFFCLSEACLRKRFRITLDHALEKISRAIEYA 120
L LLA +RA+I DI + G++ V I +S+ ++ +F +L K R +A
Sbjct: 65 LKANLLAWNRAVISDIKASVACGMERVHIAIPVSD--VKAKFHGQWRVSLPKTQRLYHFA 122
Query: 121 KDHGLKVRFTPEDTTRTEWANLKRAIRLAKELKVDRISVADTTGSTHPLRFYTLVKKIVN 180
D GL V ED++R + L A+E R DT G P Y VK +V+
Sbjct: 123 VDQGLWVAVGGEDSSRADENFLLDVALYAQEWGASRFRFCDTVGVLDPFTTYGKVKLLVS 182
Query: 181 -FGIPVNVHCHNDLGLALANAIMGIEAGATLVDATVNGLGERAGIVDLAQIITVLYYHYG 239
IPV VH HND G+A NA+ GI+AGA+ V+ TV GLGERAG L +++ + YG
Sbjct: 183 ALTIPVEVHTHNDFGMATLNALAGIKAGASSVNTTVIGLGERAGNAALEEVVMAIKRIYG 242
Query: 240 I-------KKYRLDLLYRVSNLVSEITGISPQPNYPIVGENAFTHKAGLHVSAVLKDPRF 292
+ + L L + ++ G P++ F H V + P
Sbjct: 243 VDMGIDTPRLLELSQLVAAAPVLMSHLGRRSLVKIPLLTNQVFMHM----VYCKILIPMN 298
Query: 293 YEFLPAEVFGRERTIYVDRYAGKDTIRYYLEKFGI-----RDHGIVTSL-LRKVKSSREP 346
+ L V G R + V +++G+ ++ LE+ GI ++ ++ L+ +K R+
Sbjct: 299 HSHLKRSV-GNARLV-VGKHSGRHSVSNLLEQHGIFLNPEETQSVLDAVRLQSIKKKRQ- 355
Query: 347 FTWEKLLEEARRVK 360
F + + +E +R +
Sbjct: 356 FDYRRTVELGQRTE 369
>sp|O04974|LU1B_LYCPN 2-ISOPROPYLMALATE SYNTHASE B (ALPHA-ISOPROPYLMALATE SYNTHASE B)
(ALPHA-IPM SYNTHETASE B) >gi|2213884|gb|AAB61599.1|
(AF004166) 2-isopropylmalate synthase [Lycopersicon
pennellii]
Length = 612
Score = 153 bits (383), Expect = 3e-36
Identities = 106/334 (31%), Positives = 166/334 (48%), Gaps = 36/334 (10%)
Query: 2 VLDSTLREGEQTPGVNYTPEQRLEIAIALDEVGVDFIEIGHPAVSEDVFRGMKLIAEQ-- 59
+ D+TLR+GEQ+PG T +++L++A ++GVD IE G PA SE +KLIA++
Sbjct: 73 IFDTTLRDGEQSPGATMTTKEKLDVARQSAKLGVDIIEAGFPASSEADLEAVKLIAKEVG 132
Query: 60 -GLNVE-----LLAHSRALIEDID-------YVLKTGVDWVGIFFCLSEACLRKRFRITL 106
G+ E + +R +DID Y K + F SE + + +++
Sbjct: 133 NGVYEEEYVPVICGLARCNKKDIDKAWEAVKYAKKPRIH---TFIATSEVHMNYKLKMSR 189
Query: 107 DHALEKISRAIEYAKDHGLK-VRFTPEDTTRTEWANLKRAIRLAKELKVDRISVADTTGS 165
D +EK + YA+ G + V F+PED R++ L + + +++ DT G
Sbjct: 190 DQVVEKARSMVAYARSIGCEDVEFSPEDAGRSDPEFLYHILGEVIKAGATTLNIPDTVGY 249
Query: 166 THPLRFYTLVKKIVN-----FGIPVNVHCHNDLGLALANAIMGIEAGATLVDATVNGLGE 220
T P F L+ KI + ++ HC NDLGL+ AN + G AGA ++ T+NG+GE
Sbjct: 250 TVPEEFGQLIAKIKANTPGVEDVIISTHCQNDLGLSTANTLAGACAGARQLEVTINGIGE 309
Query: 221 RAGIVDLAQIITVLY---------YHYGIKKYRLDLLYRVSNLVSEITGISPQPNYPIVG 271
RAG L +++ L + GI + S +V I+G+ QP+ IVG
Sbjct: 310 RAGNASLEEVVMALKCRGEQVLGGLYTGINTQH---ILMSSKMVEGISGLHVQPHKAIVG 366
Query: 272 ENAFTHKAGLHVSAVLKDPRFYEFLPAEVFGRER 305
NAF H++G+H +LK YE + E G R
Sbjct: 367 ANAFVHESGIHQDGMLKHKDTYEIISPEDIGLNR 400
>sp|P23122|NIFV_AZOCH HOMOCITRATE SYNTHASE >gi|280010|pir||C43706 nifV protein -
Azotobacter chroococcum >gi|142389|gb|AAA22161.1|
(M60090) homocitrate synthase [Azotobacter chroococcum]
Length = 382
Score = 152 bits (380), Expect = 6e-36
Identities = 108/330 (32%), Positives = 170/330 (50%), Gaps = 12/330 (3%)
Query: 4 DSTLREGEQTPGVNYTPEQRLEIAIALDEVGVDFIEIGHPAVSEDVFRGMKLIAEQGLNV 63
D+TLR+GEQ+ GV + ++++ I AL E+GV +EIG P++ E+ M+ IA GL+
Sbjct: 8 DTTLRDGEQSAGVAFNADEKIAIRRALAELGVPELEIGIPSMGEEEREVMRAIAGLGLSS 67
Query: 64 ELLAHSRALIEDIDYVLKTGVDWVGIFFCLSEACLRKRFRITLDHALEKISRAIEYAKDH 123
LLA R D+ TGV V + +S+ LR + D AL +++R + A+
Sbjct: 68 RLLAWCRLCDFDLSAARSTGVTMVDLSLPISDLMLRHKLNRDRDWALGEVARLVSEARMA 127
Query: 124 GLKVRFTPEDTTRTEWANLKRAIRLAKELKVDRISVADTTGSTHPL----RFYTLVKKIV 179
GL+V ED +R + + R +A+ + + ADT G P RF L +++
Sbjct: 128 GLEVCLGCEDASRADQDFIVRVGAVAQAARPPP-AFADTVGVMEPFGMLDRFRFLRQRL- 185
Query: 180 NFGIPVNVHCHNDLGLALANAIMGIEAGATLVDATVNGLGERAGIVDLAQIITVLYYHYG 239
+ + VH H+D GLA AN + + GAT ++ TVNGLGERA L + + L +G
Sbjct: 186 --DVELEVHAHDDFGLATANTLAAVMGGATHINTTVNGLGERAANAALEECVLALKNLHG 243
Query: 240 IKKYRLDL--LYRVSNLVSEITGISPQPNYPIVGENAFTHKAGLHVSAVLKDPRFYEFLP 297
I +D + +S LV +G P FTH+AG+HV +LK R YE L
Sbjct: 244 IDT-GIDTRGIPAISALVERASG-RQWPGRRAWLAPVFTHEAGIHVDGLLKHRRNYEGLN 301
Query: 298 AEVFGRERTIYVDRYAGKDTIRYYLEKFGI 327
+ GR ++ + +++G +R + GI
Sbjct: 302 PDELGRSHSLVLGKHSGAHMVRNSYRELGI 331
>gb|AAG31380.1| (AF197449) 2-isopropylmaltate synthase [Buchnera aphidicola]
Length = 486
Score = 151 bits (378), Expect = 1e-35
Identities = 97/323 (30%), Positives = 161/323 (49%), Gaps = 22/323 (6%)
Query: 25 EIAIALDEVGVDFIEIGHPAVSEDVFRGMKLIAEQGLNVELLAHSRALIEDIDYVLK--- 81
+IA+ L++ GVD +E+G P S F+ +++I++ N + + +R + +DID +
Sbjct: 1 QIALCLEKAGVDIMEVGFPISSPGDFKSVQIISQHIKNSRICSLARCIEKDIDAAGEAMS 60
Query: 82 -TGVDWVGIFFCLS----EACLRKRFRITLDHALEKISRAIEYAKDHGLKVRFTPEDTTR 136
+ + IF S E+ LRK F +D A+ + RA+ Y D + F+ ED +R
Sbjct: 61 VSDAFRIHIFLATSTLHMESKLRKNFDEIIDMAIFSVKRALRYTDD----IEFSCEDASR 116
Query: 137 TEWANLKRAIRLAKELKVDRISVADTTGSTHPLRF-----YTLVKKIVNFGIPVNVHCHN 191
T NL R + V I++ DT G T P HCH+
Sbjct: 117 TTIDNLCRIVEKLISFGVKTINIPDTVGYTVPNELSXXXXXXXXXXXXXXXXXXXXHCHD 176
Query: 192 DLGLALANAIMGIEAGATLVDATVNGLGERAGIVDLAQIITVLYYHYGIKKYRLDL---- 247
DLG+A+ N+I I+AGA ++ T+NG+GERAG L ++I + I ++
Sbjct: 177 DLGMAVGNSISAIQAGARQIEGTINGIGERAGNTALEEVIMAIKVREDILGLSTNINYKE 236
Query: 248 LYRVSNLVSEITGISPQPNYPIVGENAFTHKAGLHVSAVLKDPRFYEFLPAEVFGRERT- 306
+YR S +VS I + N IVG NAF+H +G+H VLK+ YE + G +R
Sbjct: 237 IYRTSQIVSRICNMPIPSNKAIVGSNAFSHSSGIHQDGVLKNRENYEIMDPSSIGLKRVK 296
Query: 307 IYVDRYAGKDTIRYYLEKFGIRD 329
+ + +G+ ++YY+ + G ++
Sbjct: 297 LNLTSRSGRAAVKYYMSEMGYKE 319
>sp|P54610|NIFV_FRASP HOMOCITRATE SYNTHASE >gi|1280032|gb|AAB36875.1| (U53363)
homocitrate synthase [Frankia sp.]
Length = 401
Score = 150 bits (375), Expect = 2e-35
Identities = 101/327 (30%), Positives = 166/327 (49%), Gaps = 7/327 (2%)
Query: 4 DSTLREGEQTPGVNYTPEQRLEIAIALDEVGVDFIEIGHPAVSEDVFRGMKLIAEQGLNV 63
D+TLR+GEQ PGV +T ++L IA ALD +GV IE G P + ++ I
Sbjct: 26 DTTLRDGEQAPGVAFTAAEKLAIAGALDAIGVHQIEAGIPGMGVTERDVLREILATDPKA 85
Query: 64 ELLAHSRALIEDIDYVLKTGVDWVGIFFCLSEACLRKRFRITLDHALEKISRAIEYAKDH 123
E++ RA D++ G+ + +S+ L+ + A ++ + D
Sbjct: 86 EIVGWCRADHRDVEAAASCGLVTAHLTIPVSDLHLKSKLERDRAWARRRVRDCVVDGTDR 145
Query: 124 GLKVRFTPEDTTRTEWANLKRAIRLAKELKVDRISVADTTGSTHPLRFYTLVKKIVN-FG 182
G++V ED +R + A + +++ V R+ ADT G P+ Y + ++V
Sbjct: 146 GMRVSVGFEDASRADDAFVTDLAGELRDVGVTRLRWADTVGLLDPVSAYDRLGRLVRAVP 205
Query: 183 IPVNVHCHNDLGLALANAIMGIEAGATLVDATVNGLGERAGIVDLAQIITVLYYHYGIKK 242
P +H H+D GLA AN I ++AG T V TV GLGERAG + ++ L + + K
Sbjct: 206 GPWEIHAHDDFGLATANTIAAVQAGFTWVSTTVLGLGERAGNAPIEEVAMALRH---LLK 262
Query: 243 YRLDLLYRVSNLVSEITGISPQP--NYPIVGENAFTHKAGLHVSAVLKDPRFYEFLPAEV 300
+DL ++++ P P +VGE+ F H++G+HV +L+ P YE EV
Sbjct: 263 LPIDLDTTSFRTLAQLVVGWPLPAGKKAVVGESVFAHESGIHVHGILRHPATYEPFDPEV 322
Query: 301 FGRERTIYVDRYAGKDTIRYYLEKFGI 327
GR R + V +++G+ ++R+ LE+ GI
Sbjct: 323 GGRRR-LTVGKHSGRASLRHALEQCGI 348
>sp|P15875|LEU1_SALTY 2-ISOPROPYLMALATE SYNTHASE (ALPHA-ISOPROPYLMALATE SYNTHASE)
(ALPHA-IPM SYNTHETASE) >gi|79038|pir||S08431
2-isopropylmalate synthase (EC 4.1.3.12) - Salmonella
typhimurium >gi|47968|emb|CAA35931.1| (X51583)
isopropylmalate synthase (AA 1-522) [Salmonella
typhimurium]
Length = 522
Score = 146 bits (364), Expect = 5e-34
Identities = 96/324 (29%), Positives = 163/324 (49%), Gaps = 27/324 (8%)
Query: 1 MVLDSTLREGEQTPGVNYTPEQRLEIAIALDEVGVDFIEIGHPAVSEDVFRGMKLIAEQG 60
++ D+TLR+GEQ + + +++L+IA+AL+ +GVD +E+G P S F ++ IA
Sbjct: 6 IIFDTTLRDGEQALQASLSAKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARTI 65
Query: 61 LNVELLAHSRALIEDID---YVLKTGVDW-VGIFFCLSEACLRKRFRITLDHALEKISRA 116
N + A +R + +DID LK + + F S + + R TLD +E+
Sbjct: 66 KNSRVCALARCVEKDIDVAAQALKVADAFRIHTFIATSPMHIATKLRRTLDEVIERAVYM 125
Query: 117 IEYAKDHGLKVRFTPEDTTRTEWANLKRAIRLAKELKVDRISVADTTGSTHPLRFYTLV- 175
++ A+++ V F+ ED RT +L R + A I++ DT G T P F ++
Sbjct: 126 VKRARNYTDDVEFSCEDAGRTPVDDLARVVEAAINAGARTINIPDTVGYTMPFEFAGIIS 185
Query: 176 ---KKIVNFG-IPVNVHCHNDLGLALANAIMGIEAGATLVDATVNGLGERAGIVDLAQII 231
+++ N ++VH H+DLG+A+ N++ + AGA V+ +NG+GERAG L ++I
Sbjct: 186 GLYERVPNIDKAIISVHTHDDLGIAVGNSLAAVHAGARQVEGAMNGIGERAGNCALEEVI 245
Query: 232 TVLYYHYGIKKYRLDLLYRVSNLVSEITGISPQPNYPIVG-----------ENAFTHKAG 280
+ K R D++ +N+ TG +P+ I + F H +G
Sbjct: 246 MAI-------KVRKDIMNVHTNINHHETGAPARPSVQICNIADPSQQSDCRQRRFRHSSG 298
Query: 281 LHVSAVLKDPRFYEFLPAEVFGRE 304
+H VLK+ YE + E G E
Sbjct: 299 IHQDGVLKNRENYEIMTPESIGSE 322
>gb|AAF66618.1|AF142777_1 (AF142777) homocitrate synthase [Neurospora crassa]
Length = 270
Score = 137 bits (342), Expect = 2e-31
Identities = 80/216 (37%), Positives = 118/216 (54%), Gaps = 5/216 (2%)
Query: 117 IEYAKDHGLKVRFTPEDTTRTEWANLKRAIRLAKELKVDRISVADTTGSTHPLRFYTLVK 176
IEY K GL+VRF+ ED+ R++ +L R ++ V R+ +ADT G P + Y LV+
Sbjct: 2 IEYVKSKGLEVRFSSEDSFRSDLVDLLSLYRAVDKVGVHRVGIADTVGCASPRQVYDLVR 61
Query: 177 KIVNF-GIPVNVHCHNDLGLALANAIMGIEAGATLVDATVNGLGERAGIVDLAQIIT--- 232
+ + H H+D G A+ANA +EAGAT +D +V G+GER GI L ++
Sbjct: 62 TLRGVVSCDIETHFHDDTGCAIANAYCALEAGATHIDTSVLGIGERNGITPLGGLMARMI 121
Query: 233 VLYYHYGIKKYRLDLLYRVSNLVSEITGISPQPNYPIVGENAFTHKAGLHVSAVLKDPRF 292
V Y KY+L L + +LV+E I+ N PI G AFTHKAG+H A+L +P
Sbjct: 122 VTSPDYVKSKYKLHKLKELEDLVAEAVEINTPFNNPITGFCAFTHKAGIHAKAILNNPST 181
Query: 293 YEFLPAEVFGRERTI-YVDRYAGKDTIRYYLEKFGI 327
YE L FG R + + R G + ++ + + G+
Sbjct: 182 YEILNPADFGLTRYVHFASRLTGWNAVKTRVGQLGL 217
>sp|Q00853|NIVA_CLOPA HOMOCITRATE SYNTHASE, ALPHA SUBUNIT >gi|98609|pir||B39403 probable
homocitrate synthase (EC 4.1.3.21) NifV omega chain -
Clostridium pasteurianum >gi|144879|gb|AAA23268.1|
(M68878) nitrogen fixation protein [Clostridium
pasteurianum]
Length = 269
Score = 135 bits (336), Expect = 9e-31
Identities = 81/246 (32%), Positives = 130/246 (51%), Gaps = 1/246 (0%)
Query: 2 VLDSTLREGEQTPGVNYTPEQRLEIAIALDEVGVDFIEIGHPAVSEDVFRGMKLIAEQGL 61
++D+TLR+GEQ G+ + + ++EIA + E+GV IE G PA+ D + IA GL
Sbjct: 5 IVDTTLRDGEQKAGIALSVQDKVEIAKIISEMGVHQIEAGIPAMGGDEKISVSKIAALGL 64
Query: 62 NVELLAHSRALIEDIDYVLKTGVDWVGIFFCLSEACLRKRFRITLDHALEKISRAIEYAK 121
++ A +R +DID ++ GVD V I +S+ ++ + E + R + YA
Sbjct: 65 PSKIAAWNRMSTKDIDTSIECGVDIVHISSPVSDLQIKTKLEKDRKWVAENLKRTVIYAL 124
Query: 122 DHGLKVRFTPEDTTRTEWANLKRAIRLAKELKVDRISVADTTGSTHPLRFYTLVKKIVN- 180
+ +V ED++R + L + + L V R+ ADT G P Y+ +KKI +
Sbjct: 125 EKDCEVTVGLEDSSRADLNFLIQLCEMIFALGVKRVRYADTVGIMEPKELYSQIKKIRDK 184
Query: 181 FGIPVNVHCHNDLGLALANAIMGIEAGATLVDATVNGLGERAGIVDLAQIITVLYYHYGI 240
I + +H HND G+A++N+ +AGA D T+ G+GERAG D + + V+ G
Sbjct: 185 VPIDIEIHVHNDFGMAISNSFAAFKAGAKFADCTITGMGERAGNCDFLKFVKVIQELTGE 244
Query: 241 KKYRLD 246
K Y D
Sbjct: 245 KIYTGD 250
>sp|P70728|NIFV_AZOBR HOMOCITRATE SYNTHASE >gi|1597740|gb|AAC46178.1| (U26427) nifV
[Azospirillum brasilense]
Length = 376
Score = 127 bits (316), Expect = 2e-28
Identities = 95/296 (32%), Positives = 147/296 (49%), Gaps = 16/296 (5%)
Query: 1 MVLDSTLREGEQTPGVNYTPEQRLEIAIALDEVGVDFIEIGHPAVSEDVFRGMKLIAEQG 60
++ D+ R+GEQT GV +T ++++ IA ALDE GV +EIG PA+ + ++ +A G
Sbjct: 6 IINDTHARDGEQTAGVAFTLDEKIAIAQALDEAGVAELEIGIPAMGREERERIRAVASLG 65
Query: 61 LNVELLAHSRALIEDIDYVLKTGVDWVGIFFCLSEACLRKRFRITLDHALEKISRAIEYA 120
L L+ R + D D ++ + +S+ + K+ + AL +I R ++ A
Sbjct: 66 LKARLMVWCR--MHDTDLKARSTAVAPSLSVPVSDIHITKKLNGSRAWALREIERKVKTA 123
Query: 121 KDHGLKVRFTPEDTTRTEWANLKRAIRLAKELKVDRISVADTTGSTHPLRFYTLVKKIVN 180
+DHGL+V ED++R + L A +A+ R ADT G P + L
Sbjct: 124 RDHGLEVSLGGEDSSRADMDFLIAAATVAQR---PRFRFADTLGVLDPFQHARLHLTAAA 180
Query: 181 FGIPVNVHCHNDLGLALANA-----IMGIEAGATLVDATVNGLGERAGIVDLAQIITVLY 235
+ H H LANA + + GAT V+ TVNGLGERAG L +++ L
Sbjct: 181 TDPEIGYHAHTP---RLANATAWVTLAAVLGGATHVNTTVNGLGERAGNAPLEEVVVSLK 237
Query: 236 YHYGIKKYRLD--LLYRVSNLVSEITGISPQPNYPIVGENAFTHKAGLHVSAVLKD 289
YG + +D L +S+LV + N IV + FTH+AG+HV +L D
Sbjct: 238 VLYG-QDCGVDTRALGAISDLVERASNRPVAVNKSIVRDAVFTHEAGIHVDGLLTD 292
>sp|Q56216|LEU1_THETH 2-ISOPROPYLMALATE SYNTHASE (ALPHA-ISOPROPYLMALATE SYNTHASE)
(ALPHA-IPM SYNTHETASE) >gi|1293674|gb|AAB01162.1|
(U52907) isopropylmalate synthase [Thermus thermophilus]
Length = 331
Score = 115 bits (286), Expect = 7e-25
Identities = 57/152 (37%), Positives = 90/152 (58%), Gaps = 5/152 (3%)
Query: 183 IPVNVHCHNDLGLALANAIMGIEAGATLVDATVNGLGERAGIVDLAQIITVLY----YHY 238
+ ++ H H+DLG+A ANA+ G+E GA ++ T+NG+GERAG L +++ LY ++
Sbjct: 10 VVISTHTHDDLGMATANALAGVENGAGQIECTINGIGERAGNCALEEVVMALYVRRDWYK 69
Query: 239 GIKKYRLDLLYRVSNLVSEITGISPQPNYPIVGENAFTHKAGLHVSAVLKDPRFYEFLPA 298
+ +YRVS LV TG+ PN IVG+NAF H++G+H V+K YE + A
Sbjct: 70 AYTRINTREIYRVSRLVERYTGMPVPPNKAIVGDNAFAHESGIHQDGVIKHRATYEIMDA 129
Query: 299 EVFGRERTIYV-DRYAGKDTIRYYLEKFGIRD 329
E+ GR + V +++G+ + LE G +D
Sbjct: 130 ELIGRRPAVLVLGKHSGRAAFKKALEDLGYKD 161
>emb|CAA91564.1| (Z67750) putative protein [Saccharomyces cerevisiae]
>gi|1903292|emb|CAA98756.1| (Z74229) ORF YDL182w
[Saccharomyces cerevisiae]
Length = 254
Score = 115 bits (285), Expect = 9e-25
Identities = 64/179 (35%), Positives = 100/179 (55%), Gaps = 5/179 (2%)
Query: 154 VDRISVADTTGSTHPLRFYTLVKKIVNF-GIPVNVHCHNDLGLALANAIMGIEAGATLVD 212
V+R+ +ADT G +P + Y L++ + + + H HND G A+ANA +E GA L+D
Sbjct: 3 VNRVGIADTVGCANPRQVYELIRTLKSVVSCDIECHFHNDTGCAIANAYTALEGGARLID 62
Query: 213 ATVNGLGERAGIVDLAQIIT---VLYYHYGIKKYRLDLLYRVSNLVSEITGISPQPNYPI 269
+V G+GER GI L ++ V Y KY+L + + NLV++ ++ N PI
Sbjct: 63 VSVLGIGERNGITPLGGLMARMIVAAPDYVKSKYKLHKIRDIENLVADAVEVNIPFNNPI 122
Query: 270 VGENAFTHKAGLHVSAVLKDPRFYEFLPAEVFGRERTI-YVDRYAGKDTIRYYLEKFGI 327
G AFTHKAG+H A+L +P YE L FG +R I + +R G + I+ +++ +
Sbjct: 123 TGFCAFTHKAGIHAKAILANPSTYEILDPHDFGMKRYIHFANRLTGWNAIKARVDQLNL 181
>emb|CAA72697.1| (Y11966) 2-isopropylmalate synthase [Buchnera aphidicola]
Length = 375
Score = 115 bits (285), Expect = 9e-25
Identities = 64/205 (31%), Positives = 110/205 (53%), Gaps = 12/205 (5%)
Query: 136 RTEWANLKRAIRLAKELKVDRISVADTTGSTHPLRFYTLVKKIVNFGIP------VNVHC 189
RT NL R + A + I++ DT G T P +F T++K + N +P ++ HC
Sbjct: 2 RTSIDNLCRIVESAIKAGATTINIPDTVGYTIPSQFKTIIKNLFN-KVPNINNAIISAHC 60
Query: 190 HNDLGLALANAIMGIEAGATLVDATVNGLGERAGIVDLAQIITVLYYHYGIKKYRLDL-- 247
H+DLGLA+ NAI IEAG ++ T++G+GERAG L ++I + + ++
Sbjct: 61 HDDLGLAVGNAIASIEAGVRQIEGTISGIGERAGNTALEEVILTIKLKEELLNVFTNIKH 120
Query: 248 --LYRVSNLVSEITGISPQPNYPIVGENAFTHKAGLHVSAVLKDPRFYEFLPAEVFG-RE 304
LYR S L+S++ N I+G NAF H +G+H +LK+ YE + + G +
Sbjct: 121 NELYRTSQLISQLCNTPIPANKSIIGSNAFAHSSGIHQDGILKNRANYEIIDPKTIGVKA 180
Query: 305 RTIYVDRYAGKDTIRYYLEKFGIRD 329
+ + +G+ +++++ + G +D
Sbjct: 181 VQLNLTSRSGRAAVKHHMHEMGYQD 205
>emb|CAB60077.1| (Y18874) 2-isopropylmalate synthase [Synechococcus PCC6301]
Length = 268
Score = 92.4 bits (226), Expect = 7e-18
Identities = 78/251 (31%), Positives = 118/251 (46%), Gaps = 21/251 (8%)
Query: 2 VLDSTLREGEQTPGVNYTPEQRLEIAIALDEVGVDFIEIGHPAVS-EDVFRGMKLIAEQG 60
V D+TLR+G Q G++ + E +L IA LD +GV FIE G P + +DV +L
Sbjct: 11 VYDTTLRDGAQREGLSLSLEDKLRIAHCLDRLGVKFIEGGWPGANPKDVQFFWELQQRPL 70
Query: 61 LNVELLAHSRAL----IEDIDYVLKT----GVDWVGIFFCLSEACLRKRFRITLDHALEK 112
E++A I D +LK G WV IF + + + + +LD L
Sbjct: 71 QQAEVVAFCSTRRPGQIAGEDELLKALLAAGTTWVTIFGKSWDLHVVEGLKTSLDENLVM 130
Query: 113 ISRAIEYAKDHGLKVRFTPEDTTRTEWANLKRAIRL---AKELKVDRISVADTTGSTHPL 169
IS +I Y + +V + E AN A++ A E + I + DT G P
Sbjct: 131 ISDSIAYLRTCDRRVIYDAEHWFDGYLANPDYALQTLAAAIEAGAEWIVLCDTNGGCLPH 190
Query: 170 RFYTLVKKIVN---------FGIPVNVHCHNDLGLALANAIMGIEAGATLVDATVNGLGE 220
+ +V +++ G + +H HND A+ANAI ++AGA +V T+NG GE
Sbjct: 191 QISEIVAAVLDRFPSLAPDQTGPQLGIHTHNDSETAVANAIAAVQAGARMVHGTINGYGE 250
Query: 221 RAGIVDLAQII 231
R G +L +I
Sbjct: 251 RCGNANLCSVI 261
>pir||B70567 probable mhpE protein - Mycobacterium tuberculosis (strain H37RV)
>gi|2104392|emb|CAB08693.1| (Z95390) mhpE [Mycobacterium
tuberculosis]
Length = 336
Score = 78.8 bits (191), Expect = 9e-14
Identities = 71/278 (25%), Positives = 118/278 (41%), Gaps = 31/278 (11%)
Query: 1 MVLDSTLREGEQTPGVNYTPEQRLEIAIALDEVGVDFIEIGH-----------PAV--SE 47
+VLD+T+R+G YT + I LD G+ +IEIGH PA E
Sbjct: 11 IVLDTTVRDGSYAVNFQYTDDDVRRIVGDLDAAGIPYIEIGHGVTIGAAAAQGPAAHTDE 70
Query: 48 DVFRGMKLIAEQGLNVELLAHSRALIEDIDYVLKTGVDWVGIFFCLSEACLRKRFRITLD 107
+ FR + + ++ + A IE +D G + C+ +
Sbjct: 71 EYFRAARSVVRNARLGAVIVPALARIETVDLA--------GDYLDFLRICV-------IA 115
Query: 108 HALEKISRAIEYAKDHGLKVRFTPEDTTRTEWANLKRAIRLAKELKVDRISVADTTGSTH 167
E + +E A+ GL+V + E L A + A+++ V + V DTTG+
Sbjct: 116 TEFELVMPFVERAQSKGLEVSIQLVKSHLFEPDVLAAAGKRARDVGVRIVYVVDTTGTFL 175
Query: 168 PLRFYTLVKKIVNFG-IPVNVHCHNDLGLALANAIMGIEAGATLVDATVNGLGERAGIVD 226
P V+ + + V H HN+L +A+AN + +AGA +D T+ G G AG
Sbjct: 176 PEDARRYVEALRGASDVSVGFHGHNNLAMAVANTLEAFDAGADFLDGTLMGFGRGAGNCQ 235
Query: 227 LAQIITVLYYHYGIKKYRLDLLYRVSNLVSEITGISPQ 264
+ ++ L + LD ++ + S++ G SPQ
Sbjct: 236 IECLVAALQRRGHLAAVDLDRIFDAAR--SDMLGRSPQ 271
>dbj|BAA90528.1| (AB029822) 2-phosphinomethylmalic acid synthase [Streptomyces
hygroscopicus]
Length = 440
Score = 77.3 bits (187), Expect = 3e-13
Identities = 77/287 (26%), Positives = 120/287 (40%), Gaps = 24/287 (8%)
Query: 60 GLNVELLAHSRALIEDIDYVLKTGVDWVGIFFCLSEACLRKRFRIT-LDHALEKISRAIE 118
G +E RA ED++ + + GV G+ S+ +F A A+
Sbjct: 104 GAPIEPTTWIRARREDVELIKRIGVIETGLLSSSSDYHTFHKFGSGGRTQAASMYLDAVT 163
Query: 119 YAKDHGLKVRFTPEDTTRTE--------WANLKRAIRLAKELKVDRISVADTTGSTHPLR 170
A DHG++ R EDTTR+ LK A R EL+ R V DT G P
Sbjct: 164 MALDHGIRPRVHLEDTTRSSPDFVRALVEEVLKTAERYPAELQ-PRFRVCDTLGIGLPYD 222
Query: 171 FYTLVKKIVN-------FGIP---VNVHCHNDLGLALANAIMGIEAGATLVDATVNGLGE 220
+L + I FG+ + +H HND L +AN + I G ++ T G GE
Sbjct: 223 DVSLPRSIPRWIRLLRGFGLSPSQIELHPHNDTWLVVANCLAAIREGCGVISGTTLGTGE 282
Query: 221 RAGIVDLAQIITVL--YYHYGIKKYRLDLLYRVSNLVSEITGISPQPNYPIVGENAFTHK 278
R G L ++ L ++ + L + ++ L I G P YP G +A+ +
Sbjct: 283 RTGNAPLEAVMVHLLGMGYWSGARVNLPAVNKLVELYEGI-GAGPSQKYPFFGRDAYVTR 341
Query: 279 AGLHVSAVLKDPRFYEFLPAEVF-GRERTIYVDRYAGKDTIRYYLEK 324
AG+H + K Y A + GRE + + + +G+ + + L K
Sbjct: 342 AGIHADGLNKFWWMYAPFNAPLLTGRELDVALTKDSGQAGLLFVLNK 388
Database: ./suso.pep
Posted date: Jul 6, 2001 5:57 PM
Number of letters in database: 840,471
Number of sequences in database: 2977
Database: /banques/blast2/nr.pep
Posted date: Dec 14, 2000 12:46 PM
Number of letters in database: 188,266,275
Number of sequences in database: 595,510
Lambda K H
0.322 0.140 0.407
Gapped
Lambda K H
0.270 0.0470 0.230
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 129731729
Number of Sequences: 2977
Number of extensions: 5366164
Number of successful extensions: 12107
Number of sequences better than 1.0e-10: 96
Number of HSP's better than 0.0 without gapping: 39
Number of HSP's successfully gapped in prelim test: 57
Number of HSP's that attempted gapping in prelim test: 11810
Number of HSP's gapped (non-prelim): 97
length of query: 361
length of database: 189,106,746
effective HSP length: 55
effective length of query: 306
effective length of database: 156,189,961
effective search space: 47794128066
effective search space used: 47794128066
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 41 (21.9 bits)
S2: 166 (69.1 bits)