BLASTP 2.0.10 [Aug-26-1999]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= PAB0298 (aroB) DE:3-DEHYDROQUINATE SYNTHASE
(338 letters)
Database: ./suso.pep; /banques/blast2/nr.pep
598,487 sequences; 189,106,746 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
pir||C75161 3-dehydroquinate synthase PAB0298 - Pyrococcus abyss... 666 0.0
sp|P73997|AROB_SYNY3 3-DEHYDROQUINATE SYNTHASE >gi|7428410|pir||... 218 7e-56
sp|P43879|AROB_HAEIN 3-DEHYDROQUINATE SYNTHASE >gi|1073786|pir||... 212 7e-54
sp|P77980|AROB_SALTY 3-DEHYDROQUINATE SYNTHASE >gi|1619336|emb|C... 209 4e-53
pir||G83015 3-dehydroquinate synthase PA5038 [imported] - Pseudo... 205 5e-52
sp|P07639|AROB_ECOLI 3-DEHYDROQUINATE SYNTHASE >gi|68385|pir||SY... 204 1e-51
dbj|BAB05376.1| (AP001512) 3-dehydroquinate synthase [Bacillus h... 203 2e-51
gb|AAK40642.1| 3-dehydroquinate synthase (aroB) [Sulfolobus solf... 203 2e-51
pir||B82053 3-dehydroquinate synthase VC2628 [imported] - Vibrio... 202 6e-51
dbj|BAB10417.1| (AB011474) 3-dehydroquinate synthase-like protei... 201 1e-50
sp|P57604|AROB_BUCAI 3-DEHYDROQUINATE SYNTHASE >gi|10039197|dbj|... 198 8e-50
sp|Q9X5D2|AROB_CORGL 3-DEHYDROQUINATE SYNTHASE >gi|4689272|gb|AA... 196 2e-49
emb|CAB93374.1| (AL357523) 3-dehydroquinate synthase [Streptomyc... 195 5e-49
sp|O84374|AROB_CHLTR 3-DEHYDROQUINATE SYNTHASE >gi|7437198|pir||... 193 3e-48
pir||E81376 3-dehydroquinate synthase (EC 4.6.1.3) Cj1008c [impo... 191 8e-48
gb|AAF73582.1| (AE002332) 3-dehydroquinate synthase [Chlamydia m... 190 2e-47
pir||G81984 3-dehydroquinate synthase (EC 4.6.1.3) NMA0647 [impo... 190 2e-47
sp|P31102|AROB_BACSU 3-DEHYDROQUINATE SYNTHASE >gi|7437194|pir||... 188 7e-47
sp|P96749|AROB_CORPS 3-DEHYDROQUINATE SYNTHASE >gi|1857931|gb|AA... 187 1e-46
pir||G81038 3-dehydroquinate synthase NMB1814 [imported] - Neiss... 187 1e-46
pir||S17768 3-dehydroquinate synthase (EC 4.6.1.3) aroB - Mycoba... 187 2e-46
sp|O50468|AROB_NEIGO 3-DEHYDROQUINATE SYNTHASE >gi|2661441|emb|C... 187 2e-46
sp|P36919|AROB_MYCTU 3-DEHYDROQUINATE SYNTHASE >gi|1781064|emb|C... 186 3e-46
pir||C82693 3-dehydroquinate synthase XF1334 [imported] - Xylell... 183 2e-45
gb|AAC01717.1| (AF040570) aminodehydroquinate synthase [Amycolat... 182 5e-45
sp|P56081|AROB_HELPY 3-DEHYDROQUINATE SYNTHASE >gi|7437193|pir||... 178 6e-44
sp|Q9Z6M3|AROB_CHLPN 3-DEHYDROQUINATE SYNTHASE >gi|7437197|pir||... 176 3e-43
emb|CAA72782.1| (Y12061) 3-dehydroquinate synthase [Helicobacter... 175 7e-43
sp|Q9YEJ9|AROB_AERPE 3-DEHYDROQUINATE SYNTHASE >gi|7437196|pir||... 174 1e-42
gb|AAD28456.1|AF127374_11 (AF127374) MitP [Streptomyces lavendulae] 174 2e-42
sp|Q9ZMF2|AROB_HELPJ 3-DEHYDROQUINATE SYNTHASE >gi|7437192|pir||... 173 3e-42
sp|Q9WYI3|ARKB_THEMA BIFUNCTIONAL SHIKIMATE KINASE/3-DEHYDROQUIN... 173 3e-42
emb|CAC11430.1| (AL445063) 3-dehyroquinate synthase related prot... 170 2e-41
gb|AAC14006.1| (U33059) aminodehydroquinate synthase [Actinosynn... 169 4e-41
pir||B75478 3-dehydroquinate synthase - Deinococcus radiodurans ... 168 1e-40
gi|6320332 pentafunctional arom polypeptide (contains: 3-dehydro... 161 1e-38
gb|AAF05326.1| (AF181869) 3-dehydroquinate synthetase homolog [L... 161 1e-38
gb|AAC35272.1| (AF053071) dehydroquinate synthetase [Corynebacte... 160 3e-38
gb|AAD31825.1| (AF131877) aminodehydroquinate synthase [Streptom... 157 2e-37
sp|Q12659|ARO1_PNECA PENTAFUNCTIONAL AROM POLYPEPTIDE [INCLUDES:... 155 5e-37
emb|CAA40251.1| (X56928) ORF2~gtg start codon [Actinoplanes teic... 155 7e-37
pir||T50113 pentafunctional enzyme arom [imported] - fission yea... 155 7e-37
pir||BVASA1 aroM protein - Emericella nidulans 150 3e-35
sp|P07547|ARO1_EMENI PENTAFUNCTIONAL AROM POLYPEPTIDE [INCLUDES:... 150 3e-35
pdb|1DQS|B Chain B, Crystal Structure Of Dehydroquinate Synthase... 150 3e-35
dbj|BAA83344.1| (AB019237) 2-deoxy-scyllo-inosose synthase 41 KD... 133 2e-30
emb|CAC02872.1| (AL390114) probable 3-dehydroquinate synthase [L... 101 1e-20
sp|Q9ZAE9|ACBC_ACTS5 2-EPI-VALIOLONE SYNTHASE >gi|4033329|emb|CA... 84 2e-15
sp|P34002|AROB_PSEAE 3-DEHYDROQUINATE SYNTHASE >gi|309862|gb|AAC... 80 4e-14
gb|AAD31832.1| (AF131879) aminodehydroquinate synthase [Streptom... 80 5e-14
emb|CAC02871.1| (AL390114) probable 3-dehydroquinate synthase [L... 77 2e-13
>pir||C75161 3-dehydroquinate synthase PAB0298 - Pyrococcus abyssi (strain
Orsay) >gi|5457880|emb|CAB49370.1| (AJ248284)
3-DEHYDROQUINATE SYNTHASE [Pyrococcus abyssi]
Length = 338
Score = 666 bits (1701), Expect = 0.0
Identities = 338/338 (100%), Positives = 338/338 (100%)
Query: 1 MEGIAHMENIIFSPLSSLPSIVEELNPYKIAVLTNDMLKSLWLDKIIELLGGDVFPIVIP 60
MEGIAHMENIIFSPLSSLPSIVEELNPYKIAVLTNDMLKSLWLDKIIELLGGDVFPIVIP
Sbjct: 1 MEGIAHMENIIFSPLSSLPSIVEELNPYKIAVLTNDMLKSLWLDKIIELLGGDVFPIVIP 60
Query: 61 DGEEYKTIETAIKIWDELVSFGFTRKSLLIGLGGGVITDIAGFVASTYMRGTLLGFIPTT 120
DGEEYKTIETAIKIWDELVSFGFTRKSLLIGLGGGVITDIAGFVASTYMRGTLLGFIPTT
Sbjct: 61 DGEEYKTIETAIKIWDELVSFGFTRKSLLIGLGGGVITDIAGFVASTYMRGTLLGFIPTT 120
Query: 121 LLAQVDAAIGGKTGVNFHGKNMIGTFYLPNFVLISTETLSTLPRIELLNGMAEVIKYAIL 180
LLAQVDAAIGGKTGVNFHGKNMIGTFYLPNFVLISTETLSTLPRIELLNGMAEVIKYAIL
Sbjct: 121 LLAQVDAAIGGKTGVNFHGKNMIGTFYLPNFVLISTETLSTLPRIELLNGMAEVIKYAIL 180
Query: 181 DKNVYRLLQDVKNVEEIRNREDIIRESVNVKVRVVEEDLKESGKRRILNLGHTVGHAIEK 240
DKNVYRLLQDVKNVEEIRNREDIIRESVNVKVRVVEEDLKESGKRRILNLGHTVGHAIEK
Sbjct: 181 DKNVYRLLQDVKNVEEIRNREDIIRESVNVKVRVVEEDLKESGKRRILNLGHTVGHAIEK 240
Query: 241 LSGYKIKHGFAVSVGLIAAAKLGEKLYNFDSGKVIELVERFNLPTKLPYPPKDIIEAMKL 300
LSGYKIKHGFAVSVGLIAAAKLGEKLYNFDSGKVIELVERFNLPTKLPYPPKDIIEAMKL
Sbjct: 241 LSGYKIKHGFAVSVGLIAAAKLGEKLYNFDSGKVIELVERFNLPTKLPYPPKDIIEAMKL 300
Query: 301 DKKAWYGKIVFVIPVEIGRISIEDVPEELLLQVLGEIR 338
DKKAWYGKIVFVIPVEIGRISIEDVPEELLLQVLGEIR
Sbjct: 301 DKKAWYGKIVFVIPVEIGRISIEDVPEELLLQVLGEIR 338
>sp|P73997|AROB_SYNY3 3-DEHYDROQUINATE SYNTHASE >gi|7428410|pir||S75507 3-dehydroquinate
synthase - Synechocystis sp. (strain PCC 6803)
>gi|1653152|dbj|BAA18068.1| (D90911) 3-dehydroquinate
synthase [Synechocystis sp.]
Length = 361
Score = 218 bits (550), Expect = 7e-56
Identities = 136/339 (40%), Positives = 201/339 (59%), Gaps = 21/339 (6%)
Query: 18 LPSIVEELNPY----KIAVLTNDMLKSLWLDKIIELL---GGDVFPIVIPDGEEYKTIET 70
L +I + L P KI V++N + + + +I+ L G +VF +IP GE +KT+ +
Sbjct: 23 LAAIADHLAPLGLGKKIMVVSNPEIYDYYGEVVIQALQRAGYEVFQHLIPAGETHKTLAS 82
Query: 71 AIKIWDELVSFGFTRKSLLIGLGGGVITDIAGFVASTYMRGTLLGFIPTTLLAQVDAAIG 130
+++D R S L+ LGGGVI D+ GF A+T++RG +PT+LLA VDA+IG
Sbjct: 83 INELYDVAFQANLERNSTLLSLGGGVIGDMTGFGAATWLRGINFVQVPTSLLAMVDASIG 142
Query: 131 GKTGVNF-HGKNMIGTFYLPNFVLISTETLSTLPRIELLNGMAEVIKYAIL-DKNVYRLL 188
GKTGVN GKN+IG FY P V I L TLP E GMAEVIKY ++ D ++ L
Sbjct: 143 GKTGVNHPQGKNLIGAFYQPRLVYIDPVVLKTLPEREFRAGMAEVIKYGVIWDSELFTAL 202
Query: 189 QDVKNVEEIRNRED-----IIRESVNVKVRVVEEDLKESGKRRILNLGHTVGHAIEKLSG 243
++ +++ I D II+ S KV VV +D KE+G R ILN GHTVGH +E L+G
Sbjct: 203 EEAEDLSSIDRLPDELLTKIIQRSCQAKVDVVSQDEKEAGLRAILNYGHTVGHGVESLTG 262
Query: 244 Y-KIKHGFAVSVGLIAAAKLGEKLYNFDSG---KVIELVERFNLPTKLP--YPPKDIIEA 297
Y I HG AV++G+ AAAK+ L D + +L+ + LPT++P ++++ +
Sbjct: 263 YGVINHGEAVAIGMEAAAKIAHYLGLCDQSLGDRQRQLLLKTKLPTEMPPTLAVENLLAS 322
Query: 298 MKLDKKAWYGKIVFVIPVEIGRISIED-VPEELLLQVLG 335
+ DKK GK+ F++P IG+++I D V +E++ LG
Sbjct: 323 LLHDKKVKAGKVRFILPTAIGQVTISDAVTDEVIKATLG 361
>sp|P43879|AROB_HAEIN 3-DEHYDROQUINATE SYNTHASE >gi|1073786|pir||G64054 3-dehydroquinate
synthase (EC 4.6.1.3) - Haemophilus influenzae (strain
Rd KW20) >gi|1573167|gb|AAC21876.1| (U32705)
3-dehydroquinate synthase (aroB) [Haemophilus influenzae
Rd]
Length = 362
Score = 212 bits (533), Expect = 7e-54
Identities = 137/326 (42%), Positives = 193/326 (59%), Gaps = 20/326 (6%)
Query: 29 KIAVLTNDMLKSLWLDKIIELL---GGDVFPIVIPDGEEYKTIETAIKIWDELVSFGFTR 85
++ ++TN + +LD +I L G V +++PDGE+YKT+E+ I+ L+ R
Sbjct: 35 RVMIVTNPTVAQFYLDTVIYALEKRGCVVDHVLLPDGEKYKTLESLNLIFTALLQGNHGR 94
Query: 86 KSLLIGLGGGVITDIAGFVASTYMRGTLLGFIPTTLLAQVDAAIGGKTGVNFH-GKNMIG 144
+ +I LGGGVI D+AGF A++Y RG L IPTTLL+QVD+++GGKT VN GKNMIG
Sbjct: 95 DTTIIALGGGVIGDVAGFAAASYQRGVRLIQIPTTLLSQVDSSVGGKTAVNHELGKNMIG 154
Query: 145 TFYLPNFVLISTETLSTLPRIELLNGMAEVIKY-AILDKNVYRLLQDVKNVEEI-----R 198
FY P+ V+I T TL+TLP+ E+ G+AEVIKY AILD + L+ ++++E+
Sbjct: 155 AFYQPSMVIIDTLTLNTLPKREVNAGLAEVIKYGAILDYEFFEWLE--QHIDELVALHPE 212
Query: 199 NREDIIRESVNVKVRVVEEDLKESGKRRILNLGHTVGHAIEKLSGY-KIKHGFAVSVGLI 257
+ I +K VV D E G R +LNLGHT GHAIE GY HG AVS G++
Sbjct: 213 ALQHCISRCCQIKADVVARDETEKGDRALLNLGHTFGHAIETHLGYGNWLHGEAVSTGMM 272
Query: 258 AAAKLGEKLYNF---DSGKVIELVERFNLPTKLP--YPPKDIIEAMKLDKKAWYGKIVFV 312
AA L E+L + D ++ +L+ R NLPT P P+D + M DKK GK+ V
Sbjct: 273 MAAALSEELGDISIADVSRLEKLLARANLPTVSPDTMQPEDYLPHMMRDKKVLSGKLRLV 332
Query: 313 IPVEIGRISIEDVPEELLLQVLGEIR 338
+ +G+ + + E L VL IR
Sbjct: 333 LLKSLGQAYVANDTEHTL--VLNAIR 356
>sp|P77980|AROB_SALTY 3-DEHYDROQUINATE SYNTHASE >gi|1619336|emb|CAA69932.1| (Y08642)
3-dehydroquinate synthase [Salmonella typhimurium]
Length = 362
Score = 209 bits (526), Expect = 4e-53
Identities = 127/325 (39%), Positives = 192/325 (59%), Gaps = 19/325 (5%)
Query: 29 KIAVLTNDMLKSLWLDKI---IELLGGDVFPIVIPDGEEYKTIETAIKIWDELVSFGFTR 85
++ ++TN+ L L+LDK+ +E G +V +++PDGE+YK++ ++ L+ R
Sbjct: 36 QVMLVTNETLAPLYLDKVRGVLERAGVNVDSVILPDGEQYKSLTVLDTVFTALLKKPHGR 95
Query: 86 KSLLIGLGGGVITDIAGFVASTYMRGTLLGFIPTTLLAQVDAAIGGKTGVNFH-GKNMIG 144
+ L+ LGGGVI D+ GF A++Y RG +PTTLL+QVD+++GGKT VN GKNMIG
Sbjct: 96 DTTLVALGGGVIGDLTGFAAASYQRGVRFIQVPTTLLSQVDSSVGGKTAVNHPLGKNMIG 155
Query: 145 TFYLPNFVLISTETLSTLPRIELLNGMAEVIKYA-ILDKNVYRLLQDVKNVEEIRNRED- 202
FY P V++ + L TLP EL +G+AEVIKY ILD + + L+ N++ + +
Sbjct: 156 AFYQPASVVVDLDCLKTLPARELTSGLAEVIKYGIILDADFFTWLEG--NLDALLRLDGP 213
Query: 203 ----IIRESVNVKVRVVEEDLKESGKRRILNLGHTVGHAIEKLSGY-KIKHGFAVSVGLI 257
IR +K VV D +E+G R +LNLGHT GHAIE GY HG AV+ G++
Sbjct: 214 AMAYCIRRCCELKAEVVAADEREAGLRALLNLGHTFGHAIEAEMGYGNWLHGEAVAAGIV 273
Query: 258 AAAKLGEKLYNF---DSGKVIELVERFNLPTKLP--YPPKDIIEAMKLDKKAWYGKIVFV 312
AA+ E+L F D+ ++I L+ER LP P +D + M DKK G++ V
Sbjct: 274 MAARASERLGQFSSADTQRIIALLERAGLPVNGPCEMSAQDYLPHMLRDKKVLAGELRLV 333
Query: 313 IPVEIGRISIE-DVPEELLLQVLGE 336
+P+ IG+ + V E++L + +
Sbjct: 334 LPLAIGKSEVRGGVSHEVVLSAIAD 358
>pir||G83015 3-dehydroquinate synthase PA5038 [imported] - Pseudomonas
aeruginosa (strain PAO1)
>gi|9951328|gb|AAG08423.1|AE004917_2 (AE004917)
3-dehydroquinate synthase [Pseudomonas aeruginosa]
Length = 368
Score = 205 bits (517), Expect = 5e-52
Identities = 133/315 (42%), Positives = 182/315 (57%), Gaps = 13/315 (4%)
Query: 29 KIAVLTNDMLKSLWLDKIIELLGG-DVFPIVIPDGEEYKTIETAIKIWDELVSFGFTRKS 87
++AV++N+ + L+L+ +++ L G +V P+V+PDGE YK ET I+D L+ RK+
Sbjct: 36 RVAVISNETVAPLYLETLLKALQGHEVTPVVLPDGEAYKQWETLQLIFDVLLKERHDRKT 95
Query: 88 LLIGLGGGVITDIAGFVASTYMRGTLLGFIPTTLLAQVDAAIGGKTGVNFH-GKNMIGTF 146
LI LGGGVI D+AGF A+ Y RG +PTTLL+QVD+++GGKTG+N GKNMIG F
Sbjct: 96 TLIALGGGVIGDMAGFAAACYQRGVNFIQVPTTLLSQVDSSVGGKTGINHPLGKNMIGAF 155
Query: 147 YLPNFVLISTETLSTLPRIELLNGMAEVIKYA-ILDKNVYRLLQ---DVKNVEEIRNRED 202
Y P V+I T +L TLP EL G+AEVIKY I D+ L+ D E +
Sbjct: 156 YQPQAVVIDTASLKTLPSRELSAGLAEVIKYGFICDEPFITWLEAHMDALLALEPTVVTE 215
Query: 203 IIRESVNVKVRVVEEDLKESGKRRILNLGHTVGHAIEKLSGYKI-KHGFAVSVGLIAAAK 261
I S K RVV D +ESG R LNLGHT GHAIE GY + HG AV G + A +
Sbjct: 216 AIERSCAAKARVVGADERESGVRATLNLGHTFGHAIETQQGYGVWLHGEAVGAGTVMALE 275
Query: 262 LGEK---LYNFDSGKVIELVERFNLPTKLP--YPPKDIIEAMKLDKKAWYGKIVFVIPVE 316
+ + L + + I L+ R LP P +D +E M +DKK G++ V+
Sbjct: 276 MSHRLGWLSAAERDRGIRLLRRAGLPVVPPAEMTAEDFMEHMAVDKKVLDGRLRLVLLQG 335
Query: 317 IGRISIE-DVPEELL 330
+G + D P E+L
Sbjct: 336 LGNAVVTGDFPREIL 350
>sp|P07639|AROB_ECOLI 3-DEHYDROQUINATE SYNTHASE >gi|68385|pir||SYECQ 3-dehydroquinate
synthase (EC 4.6.1.3) - Escherichia coli
>gi|40968|emb|CAA27495.1| (X03867) 3-dehydroquinate
synthase (aa 1-362) [Escherichia coli]
>gi|41225|emb|CAA79666.1| (Z19601) ORF, aroB. Millar G.,
Coggins J.R.; FEBS Lett. 200:11-17(1986) [Escherichia
coli] >gi|606323|gb|AAA58186.1| (U18997)
3-dehydroquinate synthase [Escherichia coli]
>gi|1789791|gb|AAC76414.1| (AE000414) 3-dehydroquinate
synthase [Escherichia coli K12]
Length = 362
Score = 204 bits (513), Expect = 1e-51
Identities = 124/325 (38%), Positives = 190/325 (58%), Gaps = 19/325 (5%)
Query: 29 KIAVLTNDMLKSLWLDKI---IELLGGDVFPIVIPDGEEYKTIETAIKIWDELVSFGFTR 85
++ ++TN+ L L+LDK+ +E G +V +++PDGE+YK++ ++ L+ R
Sbjct: 36 QVMLVTNETLAPLYLDKVRGVLEQAGVNVDSVILPDGEQYKSLAVLDTVFTALLQKPHGR 95
Query: 86 KSLLIGLGGGVITDIAGFVASTYMRGTLLGFIPTTLLAQVDAAIGGKTGVNFH-GKNMIG 144
+ L+ LGGGV+ D+ GF A++Y RG +PTTLL+QVD+++GGKT VN GKNMIG
Sbjct: 96 DTTLVALGGGVVGDLTGFAAASYQRGVRFIQVPTTLLSQVDSSVGGKTAVNHPLGKNMIG 155
Query: 145 TFYLPNFVLISTETLSTLPRIELLNGMAEVIKYA-ILDKNVYRLLQDVKNVEEIRNRED- 202
FY P V++ + L TLP EL +G+AEVIKY ILD + L++ N++ + +
Sbjct: 156 AFYQPASVVVDLDCLKTLPPRELASGLAEVIKYGIILDGAFFNWLEE--NLDALLRLDGP 213
Query: 203 ----IIRESVNVKVRVVEEDLKESGKRRILNLGHTVGHAIEKLSGY-KIKHGFAVSVGLI 257
IR +K VV D +E+G R +LNLGHT GHAIE GY HG AV+ G++
Sbjct: 214 AMAYCIRRCCELKAEVVAADERETGLRALLNLGHTFGHAIEAEMGYGNWLHGEAVAAGMV 273
Query: 258 AAAKLGEKLYNFDSG---KVIELVERFNLPTKLP--YPPKDIIEAMKLDKKAWYGKIVFV 312
AA+ E+L F S ++I L++R LP P + + M DKK G++ +
Sbjct: 274 MAARTSERLGQFSSAETQRIITLLKRAGLPVNGPREMSAQAYLPHMLRDKKVLAGEMRLI 333
Query: 313 IPVEIGRISIED-VPEELLLQVLGE 336
+P+ IG+ + V EL+L + +
Sbjct: 334 LPLAIGKSEVRSGVSHELVLNAIAD 358
>dbj|BAB05376.1| (AP001512) 3-dehydroquinate synthase [Bacillus halodurans]
Length = 322
Score = 203 bits (512), Expect = 2e-51
Identities = 127/316 (40%), Positives = 188/316 (59%), Gaps = 17/316 (5%)
Query: 33 LTNDMLKSLWLDKIIELLGG--DVFPIVIPDGEEYKTIETAIKIWDELVSFGFTRKSLLI 90
+T+D + L+LD + L + +V+P+GEE K+ + + + +G RKS++I
Sbjct: 1 MTDDQVADLYLDTVKSSLHNLAPLHAVVLPNGEETKSFDNYYALQTAALEYGLDRKSMII 60
Query: 91 GLGGGVITDIAGFVASTYMRGTLLGFIPTTLLAQVDAAIGGKTGVNFH-GKNMIGTFYLP 149
LGGGVI D+AGFVA+TYMRG +PTTLLA D+++GGK +N GKNMIG F+ P
Sbjct: 61 ALGGGVIGDLAGFVAATYMRGIAYVQVPTTLLAH-DSSVGGKVAINHPLGKNMIGAFHQP 119
Query: 150 NFVLISTETLSTLPRIELLNGMAEVIKYAIL-DKNVYRLLQD-VKNVEEIRNR--EDIIR 205
VL + +TLP E +G AEV+K+ ++ D Y LQ + + I+ E+++
Sbjct: 120 EAVLYDPQVFATLPEREWRSGFAEVVKHGLIKDAAFYAWLQKYINDFSRIQGEIAEELLL 179
Query: 206 ESVNVKVRVVEEDLKESGKRRILNLGHTVGHAIEKLSGY-KIKHGFAVSVGLIAAAKLGE 264
S+ VK +V D KE G+R +LNLGHT+GHAIE GY KI HG AV +G+I A KL E
Sbjct: 180 RSIQVKANIVAADEKEKGERALLNLGHTLGHAIEAELGYGKITHGEAVVIGIIFAMKLSE 239
Query: 265 KLYNFDSGKVIELVERF----NLPTKLP--YPPKDIIEAMKLDKKAWYGKIVFVIPVEIG 318
K+Y+ I+ +E++ T++P +I MK DKK G I FV+ E+G
Sbjct: 240 KVYH--QSLPIQDLEKWLKFLGYETRIPKGLDTGALIGTMKKDKKVERGVIRFVLLEEVG 297
Query: 319 RISIEDVPEELLLQVL 334
I++V E+L+ ++L
Sbjct: 298 HAVIKEVDEQLIRELL 313
>gb|AAK40642.1| 3-dehydroquinate synthase (aroB) [Sulfolobus solfataricus]
Length = 354
Score = 203 bits (512), Expect = 2e-51
Identities = 128/299 (42%), Positives = 177/299 (58%), Gaps = 19/299 (6%)
Query: 44 DKIIELLGGDVFPIVIPDGEEYKTIETAIKIWDELVSFGFTRKSLLIGLGGGVITDIAGF 103
DKI + L F I I DGE K + + I + ++L F R +IG+GGG +TD+AGF
Sbjct: 45 DKINKYLPNAYF-IPINDGESTKELSSVISLVEKLFEKNFDRGDYIIGVGGGTVTDVAGF 103
Query: 104 VASTYMRGTLLGFIPTTLLAQVDAAIGGKTGVNFHG-KNMIGTFYLPNFVLISTETLSTL 162
+AS Y+RG L +PTT L VDAAIGGK GVNF+ KN+IGTFY P+ ++ E L TL
Sbjct: 104 LASIYLRGLNLINVPTTFLGMVDAAIGGKNGVNFNNIKNLIGTFYQPSMIISDLEFLETL 163
Query: 163 PRIELLNGMAEVIKYAI-LDKNVYRLLQDVKNVEEIRNR-----EDIIRESVNVKVRVVE 216
P EL G+AEVIKY + LDK +Y L N E+I N+ EDII S K+ +V+
Sbjct: 164 PIEELKKGLAEVIKYGLTLDKELYDYLS--LNKEKILNKDKQALEDIIFRSTLDKLSIVK 221
Query: 217 EDLKES-GKRRILNLGHTVGHAIEKLSGYKIKHGFAVSVGLIAAAKLGEKLYNFDSG--- 272
ED +E+ G R +LN GHT+GHAIE S + + HG+A+SVG++ AK+ E+L + G
Sbjct: 222 EDERETKGIRIVLNFGHTIGHAIEAGSSFNVPHGYAISVGMVCEAKMAEELGYAEEGVVE 281
Query: 273 KVIELVERFNLPTKL-----PYPPKDIIEAMKLDKKAWYGKIVFVIPVEIGRISIEDVP 326
V+ L++ + LP + P K + A+ +DKK I+ P IG +VP
Sbjct: 282 DVLWLLQIYGLPYDISQIDAPVDLKLALNAINMDKKHRKDVILIPFPTRIGSWKKVEVP 340
>pir||B82053 3-dehydroquinate synthase VC2628 [imported] - Vibrio cholerae
(group O1 strain N16961) >gi|9657218|gb|AAF95769.1|
(AE004329) 3-dehydroquinate synthase [Vibrio cholerae]
Length = 366
Score = 202 bits (508), Expect = 6e-51
Identities = 128/331 (38%), Positives = 187/331 (55%), Gaps = 15/331 (4%)
Query: 19 PSIVEELNPYKIAVLTNDMLKSLWLDKIIELL---GGDVFPIVIPDGEEYKTIETAIKIW 75
P+++ K+ ++TN + L+ II LL G + +PDGE+YKT+ET +
Sbjct: 30 PALLSLSAKQKVVIVTNHTVAPLYAPAIISLLDHIGCQHALLELPDGEQYKTLETFNTVM 89
Query: 76 DELVSFGFTRKSLLIGLGGGVITDIAGFVASTYMRGTLLGFIPTTLLAQVDAAIGGKTGV 135
L+ ++R ++I LGGGVI D+ GF A+ Y RG IPTTLL+QVD+++GGKT V
Sbjct: 90 SFLLEHNYSRDVVVIALGGGVIGDLVGFAAACYQRGVDFIQIPTTLLSQVDSSVGGKTAV 149
Query: 136 NFH-GKNMIGTFYLPNFVLISTETLSTLPRIELLNGMAEVIKYAIL-DKNVYRLLQDVKN 193
N GKNMIG FY P V+I T+ L+TLP E GMAEVIKY I+ D + L+
Sbjct: 150 NHPLGKNMIGAFYQPKAVVIDTDCLTTLPAREFAAGMAEVIKYGIIYDSAFFDWLEAQME 209
Query: 194 VEEIRNREDI---IRESVNVKVRVVEEDLKESGKRRILNLGHTVGHAIEKLSGY-KIKHG 249
+ + + I +K VV +D KESG R +LNLGHT GHAIE GY HG
Sbjct: 210 ALYALDEQALTYAIARCCQIKAEVVAQDEKESGIRALLNLGHTFGHAIEAHMGYGNWLHG 269
Query: 250 FAVSVGLIAAAKLGEKLYNFDSG---KVIELVERFNLPTKLP--YPPKDIIEAMKLDKKA 304
AVS G + AAK + D+ +++ ++++ +LP + P D ++ M DKK
Sbjct: 270 EAVSAGTVMAAKTAQLQGLIDASQFERILAILKKAHLPVRTPENMTFADFMQHMMRDKKV 329
Query: 305 WYGKIVFVIPVEIGRIS-IEDVPEELLLQVL 334
G++ V+P IG + ++ VPE ++ Q +
Sbjct: 330 LAGELRLVLPTSIGTSAVVKGVPEAVIAQAI 360
>dbj|BAB10417.1| (AB011474) 3-dehydroquinate synthase-like protein [Arabidopsis
thaliana]
Length = 378
Score = 201 bits (505), Expect = 1e-50
Identities = 118/303 (38%), Positives = 180/303 (58%), Gaps = 20/303 (6%)
Query: 29 KIAVLTNDMLKSLWLDKIIELL-----GGDVFPIVIPDGEEYKTIETAIKIWDELVSFGF 83
++ V+TND + L+LDK I+ L V +++PDGE+YK ++T +K++D+ +
Sbjct: 49 RVLVVTNDRVAPLYLDKTIDALTRGNPNVTVESVILPDGEKYKDMDTLMKVFDKAIESRL 108
Query: 84 TRKSLLIGLGGGVITDIAGFVASTYMRGTLLGFIPTTLLAQVDAAIGGKTGVNFH-GKNM 142
R+ + LGGGVI D+ G+ A++Y+RG IPTT++AQVD+++GGKTG+N GKN+
Sbjct: 109 DRRCTFVALGGGVIGDMCGYAAASYLRGVNFIQIPTTVMAQVDSSVGGKTGINHRLGKNL 168
Query: 143 IGTFYLPNFVLISTETLSTLPRIELLNGMAEVIKYAILDKNVYRLLQDVKNVEEIRNRED 202
IG FY P VL+ T+TL+TLP E+ +G+AEVIKY ++ + Q+ KN+E + R+
Sbjct: 169 IGAFYQPQCVLVDTDTLNTLPDREMASGLAEVIKYGLIRDAEFFEWQE-KNIEALLARDP 227
Query: 203 -----IIRESVNVKVRVVEEDLKESGKRRILNLGHTVGHAIEKLSGY-KIKHGFAVSVGL 256
I+ S K VV +D KESG R LNLGHT GHAIE GY + HG AV+ G
Sbjct: 228 AALAFAIKRSCENKADVVSQDEKESGLRATLNLGHTFGHAIETGFGYGEWLHGEAVAAGT 287
Query: 257 IAAAKLGEKLYNFDSGKVIELVERFNLPTKLPYPPKDII------EAMKLDKKAWYGKIV 310
+ A + +L D +++ V + + KLP P + + M +DKK G +
Sbjct: 288 VMAVDMSYRLGWIDE-SIVKRVNKILVRAKLPTTPPESMTVSMFKSIMAVDKKVADGLLR 346
Query: 311 FVI 313
++
Sbjct: 347 LIL 349
>sp|P57604|AROB_BUCAI 3-DEHYDROQUINATE SYNTHASE >gi|10039197|dbj|BAB13231.1| (AP001119)
3-dehydroquinate synthase [Buchnera sp. APS]
Length = 363
Score = 198 bits (498), Expect = 8e-50
Identities = 136/345 (39%), Positives = 198/345 (56%), Gaps = 26/345 (7%)
Query: 14 PLSSLPSIVEE------LNPYKIAVL-TNDMLKSLWLDKIIELL---GGDVFPIVIPDGE 63
P+S I++E L P A+L TN L +L DK+ L G + +++ DGE
Sbjct: 17 PISIGAGIIQEDDIFWPLKPGDQAMLVTNKTLANLLKDKVFYHLRKSGIKIDQVILSDGE 76
Query: 64 EYKTIETAIKIWDELVSFGFTRKSLLIGLGGGVITDIAGFVASTYMRGTLLGFIPTTLLA 123
+YKT+ I L+ R + LI LGGGVI D+AGF AS Y RG IPTTLL+
Sbjct: 77 QYKTLNEMELIISALLEKKHARDTTLIALGGGVIGDLAGFAASVYQRGVRFIQIPTTLLS 136
Query: 124 QVDAAIGGKTGVN-FHGKNMIGTFYLPNFVLISTETLSTLPRIELLNGMAEVIKYAIL-D 181
QVDA++GGKT VN GKNMIG+F+ P+ V+I + L TLP EL++GMAEVIKYAI+ D
Sbjct: 137 QVDASVGGKTAVNHLLGKNMIGSFWQPSSVIIDIDCLKTLPYNELVSGMAEVIKYAIVFD 196
Query: 182 KNVYRLLQDVKNVEEIRNRED-----IIRESVNVKVRVVEEDLKESGKRRILNLGHTVGH 236
K + L++ N+E I + I++ +K +++ D +E+ R +LNLGHT GH
Sbjct: 197 KTFFCWLEE--NIESILSLNHTAMSYCIKKCCELKSQLIALDERENNLRALLNLGHTYGH 254
Query: 237 AIEKLSGY-KIKHGFAVSVGLIAAAKLGE---KLYNFDSGKVIELVERFNLPTKLP--YP 290
AIE +GY HG A+SVG++ AA+ E L D +++ L++R LP K P
Sbjct: 255 AIEVHAGYGNWLHGEAISVGMVMAARTSELLGHLKTIDFKRILVLLKRTGLPIKGPKNMS 314
Query: 291 PKDIIEAMKLDKKAWYGKIVFVIPVEIGRISI-EDVPEELLLQVL 334
+ M DKK G++ V+P+ IG+ I ++ + ++L +
Sbjct: 315 AASYLPYMMRDKKVISGEMRLVLPLSIGKAEIYSNIDKNIILTAI 359
>sp|Q9X5D2|AROB_CORGL 3-DEHYDROQUINATE SYNTHASE >gi|4689272|gb|AAD27840.1|AF124600_3
(AF124600) 3-dehydroquinate synthase [Corynebacterium
glutamicum]
Length = 366
Score = 196 bits (494), Expect = 2e-49
Identities = 122/301 (40%), Positives = 172/301 (56%), Gaps = 11/301 (3%)
Query: 43 LDKIIELLGGDVFPIVIPDGEEYKTIETAIKIWDELVSFGFTRKSLLIGLGGGVITDIAG 102
LD + G V + +PD E K++E A + WDEL F R+ ++IGLGGG TD+AG
Sbjct: 56 LDAALVAAGLKVLHLNVPDAENGKSLEVAGQCWDELGGAAFGRRDIVIGLGGGAATDLAG 115
Query: 103 FVASTYMRGTLLGFIPTTLLAQVDAAIGGKTGVN-FHGKNMIGTFYLPNFVLISTETLST 161
FVA+ +MRG + +PTTLLA VDAA+GGKTG+N GKN++G F+ P+ V I T+ L+T
Sbjct: 116 FVAAAWMRGVRVIQVPTTLLAMVDAAVGGKTGINTAAGKNLVGAFHEPDAVFIDTDRLAT 175
Query: 162 LPRIELLNGMAEVIKYA-ILDKNVYRLLQD-----VKNVEEIRNREDIIRESVNVKVRVV 215
LP E++ G AE+IK I D + RL + +K E + ++I SV VK VV
Sbjct: 176 LPDAEIIAGSAEIIKTGFIADPEILRLYETDPAACLKKEVEGSHLPELIWRSVTVKGSVV 235
Query: 216 EEDLKESGKRRILNLGHTVGHAIEKLSGYKIKHGFAVSVGLIAAAKLGEKLYNFDS---G 272
+DLKES R ILN GHT HA+E ++ +HG AV+VG++ A L KL D+
Sbjct: 236 GQDLKESSLREILNYGHTFAHAVELRENFRWRHGNAVAVGMMFIANLSHKLGLIDAPLLE 295
Query: 273 KVIELVERFNLPTKLPYPPKD-IIEAMKLDKKAWYGKIVFVIPVEIGRISIEDVPEELLL 331
+ ++ LPT D + + M DKK G I FV +G ++ + P + L
Sbjct: 296 RHRSILAAIGLPTSYEGGAFDELYDGMTRDKKNRDGNIRFVALTAVGEVTRIEGPSKQDL 355
Query: 332 Q 332
Q
Sbjct: 356 Q 356
>emb|CAB93374.1| (AL357523) 3-dehydroquinate synthase [Streptomyces coelicolor
A3(2)]
Length = 363
Score = 195 bits (491), Expect = 5e-49
Identities = 119/298 (39%), Positives = 177/298 (58%), Gaps = 12/298 (4%)
Query: 51 GGDVFPIVIPDGEEYKTIETAIKIWDELVSFGFTRKSLLIGLGGGVITDIAGFVASTYMR 110
G + I +P+ EE KT E A W L GFTR +++G+GGG TD+AGFVA+T++R
Sbjct: 65 GYEAIAIQVPNAEEAKTAEVAAYCWKALGQSGFTRTDVIVGVGGGASTDLAGFVAATWLR 124
Query: 111 GTLLGFIPTTLLAQVDAAIGGKTGVN-FHGKNMIGTFYLPNFVLISTETLSTLPRIELLN 169
G +PTT+L+ VDAA+GGKTG+N GKN++G+F+ P VL L +LP + ++
Sbjct: 125 GVRWIAVPTTVLSMVDAAVGGKTGINTAEGKNLVGSFHPPAGVLCDLAALDSLPVNDYVS 184
Query: 170 GMAEVIKYA-ILDKNVYRLLQ---DVKNVEEIRNREDIIRESVNVKVRVVEEDLKESGKR 225
G+AEVIK I D + L++ + ++I S+ VK VV DLKE+G R
Sbjct: 185 GLAEVIKAGFIADPAILDLIEADPQAARTPAGPHTAELIVRSIKVKAEVVSSDLKEAGLR 244
Query: 226 RILNLGHTVGHAIEKLSGYKIKHGFAVSVGLIAAAKLGE---KLYNFDSGKVIELVERFN 282
ILN GHT+GHAIEK YK +HG AVSVG+ AA+LG +L + + + ++E
Sbjct: 245 EILNYGHTLGHAIEKNERYKWRHGAAVSVGMHFAAELGRLAGRLDDATADRHRSILEAVG 304
Query: 283 LPTKLPYP--PKDIIEAMKLDKKAWYGKIVFVIPVEIGRISIEDVPE-ELLLQVLGEI 337
LP Y PK ++E MK+DKK+ + F++ + + ++ + P+ +LL GE+
Sbjct: 305 LPLHYRYDQWPK-LVENMKVDKKSRGDLLRFIVLDGLAKPTVLEGPDPAVLLAAYGEV 361
>sp|O84374|AROB_CHLTR 3-DEHYDROQUINATE SYNTHASE >gi|7437198|pir||B71523 probable
dehyroquinate synthase - Chlamydia trachomatis
(serotype D, strain UW3/Cx) >gi|3328793|gb|AAC67965.1|
(AE001310) Dehyroquinate Synthase [Chlamydia
trachomatis]
Length = 373
Score = 193 bits (485), Expect = 3e-48
Identities = 130/335 (38%), Positives = 190/335 (55%), Gaps = 26/335 (7%)
Query: 28 YKIAVLTNDMLKSLWLDKIIEL---LGGDVFPIVIPDGEEYKTIETAIKIWDELVSFGFT 84
+ + +TN L +L L +++L LG V + IP+GEE KT +T + + +L
Sbjct: 31 FPLIFITNTKLNALILPPLLDLARSLGFSVETLTIPEGEETKTGDTFLSLHQQLTDLNVP 90
Query: 85 RKSLLIGLGGGVITDIAGFVASTYMRGTLLGFIPTTLLAQVDAAIGGKTGVNF-HGKNMI 143
R++ LIG+GGGVI DIAGFVA+T+ RG IPTTL+A +DA+IGGK G+N H KN I
Sbjct: 91 RQATLIGVGGGVILDIAGFVAATHCRGMPFIAIPTTLVAMIDASIGGKNGINLNHIKNRI 150
Query: 144 GTFYLPNFVLISTETLSTLPRIELLNGMAEVIKYA-ILDKNVYRLLQDVKNVEEIRNRED 202
G+FYLP V I LS LP+ EL +G+AE IK+A I D + LLQD +++
Sbjct: 151 GSFYLPKAVWICPRKLSFLPQQELHHGIAECIKHAYIADSAILPLLQDPNALKKEDKLSL 210
Query: 203 IIRESVNVKVRVVEEDLKESGKRRILNLGHTVGHAIEKLSGYKIKHGFAVSVGLIAAAKL 262
+I+++ K VV++D+++ KR+ILN GHT+GHA+E L KI H A+SVG++ KL
Sbjct: 211 LIKKNCLCKASVVQQDVRDYAKRQILNFGHTLGHALEMLFIGKIPHSCAISVGMVLETKL 270
Query: 263 GEKLYNFDSGKV----IELVERFNLPTKL----------PYPPKDIIEAMKLDKKAWYGK 308
L S + I+ + R+ LP L P+ I+ A+ DKK
Sbjct: 271 SLSLGVARSPAILHSLIQDLLRYQLPVSLKDLYMRAQIPPHNCDQILSALTYDKKKQNTP 330
Query: 309 I-VFVIPVEIGRISIED------VPEELLLQVLGE 336
+ FV+ EIG + D + + +L +VL E
Sbjct: 331 LPPFVMIEEIGLAASFDGRFCQTISKHILTKVLEE 365
>pir||E81376 3-dehydroquinate synthase (EC 4.6.1.3) Cj1008c [imported] -
Campylobacter jejuni (strain NCTC 11168)
>gi|6968443|emb|CAB73264.1| (AL139076) 3-dehydroquinate
synthase [Campylobacter jejuni]
Length = 351
Score = 191 bits (481), Expect = 8e-48
Identities = 128/327 (39%), Positives = 187/327 (57%), Gaps = 19/327 (5%)
Query: 29 KIAVLTNDMLKSLWLDKII-ELLGGDVFPIVIPDGEEYKTIETAIKIWDELVSFGFTRKS 87
K+ +L+N + L L ++ ++ ++F + DGEEYK + T +I +++ + RKS
Sbjct: 27 KVFILSNPKISGLHLKTLLSKIKAKEIFIATVKDGEEYKNLSTMEEILNQMFNSKLDRKS 86
Query: 88 LLIGLGGGVITDIAGFVASTYMRGTLLGFIPTTLLAQVDAAIGGKTGVNFH-GKNMIGTF 146
+LI GGGVI+D+ GF AS Y RG IPTTLLA VDAA+GGKTGVN + GKN+IGTF
Sbjct: 87 VLISFGGGVISDMGGFAASIYQRGIDFINIPTTLLACVDAAVGGKTGVNNNFGKNLIGTF 146
Query: 147 YLPNFVLISTETLSTLPRIELLNGMAEVIKYAILDKNVYRLLQDVKNVEE-------IRN 199
Y P V + L TL EL GMAE IK A + Y +L ++ ++E N
Sbjct: 147 YQPKAVYCESFFLKTLSSRELAAGMAEFIKMAAMFD--YSILDFIEKIDEKSFLNATCEN 204
Query: 200 R--EDIIRESVNVKVRVVEEDLKESGKRRILNLGHTVGHAIEKLSGYKI-KHGFAVSVGL 256
II +S+ +K RVVE+D KES R +LN GHT H IE + YK+ HG AV++G+
Sbjct: 205 EIFTQIIAKSIELKSRVVEQDEKESRLRMLLNYGHTFAHVIENFTDYKLYLHGEAVAIGM 264
Query: 257 IAAAKLGEKLYNFD---SGKVIELVERFNLPTKLPYPPKD-IIEAMKLDKKAWYGKIVFV 312
+ A +L L D S ++ +++ +F LP D EA +DKK+ KI FV
Sbjct: 265 VMANQLALNLGLLDKMQSQRIKDILLKFGLPISYKINNVDEFYEAFFMDKKSSNKKINFV 324
Query: 313 IPVEIGRISIE-DVPEELLLQVLGEIR 338
+ +G+ I+ D+ +E ++ L E +
Sbjct: 325 LASPLGKGLIKGDISKEDIIATLREFQ 351
>gb|AAF73582.1| (AE002332) 3-dehydroquinate synthase [Chlamydia muridarum]
Length = 373
Score = 190 bits (478), Expect = 2e-47
Identities = 117/306 (38%), Positives = 176/306 (57%), Gaps = 20/306 (6%)
Query: 33 LTNDMLKSLWLDKIIEL---LGGDVFPIVIPDGEEYKTIETAIKIWDELVSFGFTRKSLL 89
+TN L+ L L ++E LG V ++IP+GE+ KT T + + +L + R++ L
Sbjct: 36 ITNSTLEILVLPPLLETARSLGFSVEILIIPEGEQAKTETTFLYLHKQLATLTIPRQATL 95
Query: 90 IGLGGGVITDIAGFVASTYMRGTLLGFIPTTLLAQVDAAIGGKTGVNF-HGKNMIGTFYL 148
IG+GGGV+ DI GFVAST+ RG +PTTL+A +DA+IGGK G+N H KN IG+FYL
Sbjct: 96 IGVGGGVVLDIVGFVASTHCRGMPFIAVPTTLVAMIDASIGGKNGINLDHIKNRIGSFYL 155
Query: 149 PNFVLISTETLSTLPRIELLNGMAEVIKYA-ILDKNVYRLLQDVKNVEEIRNREDIIRES 207
P V I LS+LP E +G+AE IK+A I D ++ +LQ+ ++ + +I+ +
Sbjct: 156 PKDVWICPSVLSSLPEQEFYHGIAECIKHAYIADASILPILQNPASLRSTKQLSLLIKRN 215
Query: 208 VNVKVRVVEEDLKESGKRRILNLGHTVGHAIEKLSGYKIKHGFAVSVGLIAAAKLGEKLY 267
K +V +D+++ G R+ILN GHT+GHA+E L KI HGFA+SVG++ KL +
Sbjct: 216 CLCKASIVGKDIRDHGIRQILNFGHTLGHALEMLFTGKISHGFAISVGMVLETKLSLAMG 275
Query: 268 NFDSGKVIELVE----RFNLPTKLP----------YPPKDIIEAMKLDKKAWYGKI-VFV 312
+ ++ + R+ LPT L + I+ A+ DKK + FV
Sbjct: 276 VARNPNILHFLVQDLLRYQLPTSLKDLYAQAQIPIHSCSQILSALSYDKKKQNASLPPFV 335
Query: 313 IPVEIG 318
+ EIG
Sbjct: 336 MIEEIG 341
>pir||G81984 3-dehydroquinate synthase (EC 4.6.1.3) NMA0647 [imported] -
Neisseria meningitidis (group A strain Z2491)
>gi|7379378|emb|CAB83936.1| (AL162753) 3-dehydroquinate
synthase [Neisseria meningitidis Z2491]
Length = 359
Score = 190 bits (477), Expect = 2e-47
Identities = 131/340 (38%), Positives = 188/340 (54%), Gaps = 20/340 (5%)
Query: 11 IFSPLSSLPSIVEELNPY---KIAVLTNDMLKSLWLDKI---IELLGGDVFPIVIPDGEE 64
IF LP L P+ + A++TN+ + L+L + ++ G F I++PDGE
Sbjct: 15 IFIGNGLLPQAGSLLKPHLGKRAAIITNETVAPLYLGTLQTALDAAGVSHFSIILPDGEA 74
Query: 65 YKTIETAIKIWDELVSFGFTRKSLLIGLGGGVITDIAGFVASTYMRGTLLGFIPTTLLAQ 124
+K +T I+D L+ RK+ LI LGGGVI D+ GF A+TY RG IPTTLL+Q
Sbjct: 75 HKNWQTLNLIFDGLMQNRAERKTTLIALGGGVIGDMTGFAAATYQRGAPFVQIPTTLLSQ 134
Query: 125 VDAAIGGKTGVNFH-GKNMIGTFYLPNFVLISTETLSTLPRIELLNGMAEVIKYAIL-DK 182
VD+++GGKT +N GKNMIG FY P VL +TL TLP EL GMAEVIKY L D
Sbjct: 135 VDSSVGGKTAINHPLGKNMIGAFYQPQAVLADLDTLHTLPARELSAGMAEVIKYGTLGDI 194
Query: 183 NVYRLLQDVKNVEEIRNRE-----DIIRESVNVKVRVVEEDLKESGKRRILNLGHTVGHA 237
+ + L+ +++ E+ E + +K +V +D E G R LNLGHT GHA
Sbjct: 195 SFFEWLE--QHMPELMALERAPLIQAVYRCCQMKADIVAQDETEQGIRAWLNLGHTFGHA 252
Query: 238 IEKLSGYKI-KHGFAVSVGLIAAAKLGEKLYNF---DSGKVIELVERFNLPTKLP-YPPK 292
IE GY HG AV+ G + AA+L E+L D+ ++ L+E LP+ P + +
Sbjct: 253 IETEMGYGTWLHGEAVAAGCVLAARLSEQLGKISAADTARLAALLEAAGLPSAPPVFAFE 312
Query: 293 DIIEAMKLDKKAWYGKIVFVIPVEIGRISIEDVPEELLLQ 332
+E M DKK G + F+ +G +I ++ + +L+
Sbjct: 313 KWLEHMSHDKKVSGGIMRFIGLNRLGEANITEITDTDILR 352
>sp|P31102|AROB_BACSU 3-DEHYDROQUINATE SYNTHASE >gi|7437194|pir||G69589 3-dehydroquinate
synthase aroB - Bacillus subtilis
>gi|143807|gb|AAA20860.1| (M80245) AroB [Bacillus
subtilis] >gi|2634688|emb|CAB14186.1| (Z99115)
3-dehydroquinate synthase [Bacillus subtilis]
Length = 362
Score = 188 bits (473), Expect = 7e-47
Identities = 115/304 (37%), Positives = 183/304 (59%), Gaps = 12/304 (3%)
Query: 29 KIAVLTNDMLKSLWLDKIIELLGGD--VFPIVIPDGEEYKTIETAIKIWDELVSFGFTRK 86
+I +T++ + L+ D+++ LL V + +P GE+ K+++ K+ E + F R
Sbjct: 38 RIMFVTDEEVDRLYGDEMLHLLQEKWPVKKVTVPSGEQAKSMDMYTKLQSEAIRFHMDRS 97
Query: 87 SLLIGLGGGVITDIAGFVASTYMRGTLLGFIPTTLLAQVDAAIGGKTGVNFH-GKNMIGT 145
S +I GGGV+ D+AGFVA+T+MRG +PTTLLA D+A+GGK VN GKN+IG
Sbjct: 98 SCIIAFGGGVVGDLAGFVAATFMRGIDFIQMPTTLLAH-DSAVGGKVAVNHPLGKNLIGA 156
Query: 146 FYLPNFVLISTETLSTLPRIELLNGMAEVIKYA-ILDKNVYRLLQDVKNVEEIRNRE--D 202
FY P VL T+ L +LP EL +GMAEVIK+A I D+ L ++ ++ +I N + D
Sbjct: 157 FYQPKAVLYDTDFLRSLPEKELRSGMAEVIKHAFIYDRAFLEELLNIHSLRDITNDQLND 216
Query: 203 IIRESVNVKVRVVEEDLKESGKRRILNLGHTVGHAIEKLSGY-KIKHGFAVSVGLIAAAK 261
+I + +++K VV++D KE G R LN GHT+GHA+E GY +I HG AV++G+ A
Sbjct: 217 MIFKGISIKASVVQQDEKEEGIRAYLNFGHTLGHAVEAEYGYGQITHGDAVALGMQFALY 276
Query: 262 LGEKLY--NFDSGKVIELVERFNLPTKLPYPPKD--IIEAMKLDKKAWYGKIVFVIPVEI 317
+ EK D +++ ++ P+++ + ++ M DKK GKI F++ E+
Sbjct: 277 ISEKTVGCEMDRKRLVSWLKSLGYPSQIRKETETSVLLNRMMNDKKTRGGKIQFIVLNEL 336
Query: 318 GRIS 321
G+++
Sbjct: 337 GKVA 340
>sp|P96749|AROB_CORPS 3-DEHYDROQUINATE SYNTHASE >gi|1857931|gb|AAB71614.1| (U88628)
dehydroquinate synthase [Corynebacterium
pseudotuberculosis]
Length = 358
Score = 187 bits (471), Expect = 1e-46
Identities = 120/297 (40%), Positives = 170/297 (56%), Gaps = 16/297 (5%)
Query: 47 IELLGGDVFPIVIPDGEEYKTIETAIKIWDELVSFGFTRKSLLIGLGGGVITDIAGFVAS 106
IE LG + I +PD E+ K + A WD L F RK ++I LGGG +TD+AGFVA+
Sbjct: 55 IEALGKEATIITVPDAEDGKNLNVAGDCWDVLGRKAFGRKDVIISLGGGAVTDLAGFVAA 114
Query: 107 TYMRGTLLGFIPTTLLAQVDAAIGGKTGVNFH-GKNMIGTFYLPNFVLISTETLSTLPRI 165
+MRG + +PTTLL+ VDAA+GGKTG+N GKN++G F+ P+ V I + ++TLP
Sbjct: 115 CWMRGIAVIHVPTTLLSMVDAAVGGKTGINTSAGKNLVGAFHEPSGVFIDLDMIATLPDR 174
Query: 166 ELLNGMAEVIKYA-ILDKNVYRLL-QDVKNVEEIRNREDIIRESVNVKVRVVEEDLKESG 223
E ++G AE+IK I D + L +D + R ++I SV K RVV DL+E+G
Sbjct: 175 EKISGSAEIIKTGFIADTKILSLYEEDPEACFNGRILAELIGRSVAAKARVVASDLREAG 234
Query: 224 KRRILNLGHTVGHAIEKLSGYKIKHGFAVSVGLIAAAKLG-------EKLYNFDSGKVIE 276
+R ILN GHT GHA+E Y+ +HG AVSVG++ A L ++LY +
Sbjct: 235 QREILNYGHTFGHAVELKEKYEWRHGNAVSVGMMFVAALARNRGLITDELYL----RHKN 290
Query: 277 LVERFNLPTKLPYPP-KDIIEAMKLDKKAWYGKIVFVIPVEIGR-ISIEDVPEELLL 331
++ LPT P ++ +AM DKK +I FV + G+ I IED L+
Sbjct: 291 ILSSVGLPTTYPEGHFAELYQAMLRDKKNRDDRIRFVALIGAGKTIRIEDADRAELI 347
>pir||G81038 3-dehydroquinate synthase NMB1814 [imported] - Neisseria
meningitidis (group B strain MD58)
>gi|7227067|gb|AAF42149.1| (AE002531) 3-dehydroquinate
synthase [Neisseria meningitidis MC58]
Length = 359
Score = 187 bits (471), Expect = 1e-46
Identities = 129/338 (38%), Positives = 184/338 (54%), Gaps = 16/338 (4%)
Query: 11 IFSPLSSLPSIVEELNPY---KIAVLTNDMLKSLWLDKI---IELLGGDVFPIVIPDGEE 64
IF LP L P+ + A++ N+ + L+L + ++ G F I++PDGE
Sbjct: 15 IFIGNGLLPQAGSLLKPHLGKRAAIIANETVAPLYLGTLQTALDAAGVSHFSIILPDGEA 74
Query: 65 YKTIETAIKIWDELVSFGFTRKSLLIGLGGGVITDIAGFVASTYMRGTLLGFIPTTLLAQ 124
+K +T I+D L+ RK+ LI LGGGVI D+ GF A+TY RG IPTTLL+Q
Sbjct: 75 HKNWQTLNLIFDGLMQNRAERKTTLIALGGGVIGDMVGFAAATYQRGAPFVQIPTTLLSQ 134
Query: 125 VDAAIGGKTGVNFH-GKNMIGTFYLPNFVLISTETLSTLPRIELLNGMAEVIKYAIL-DK 182
VD+++GGKT +N GKNMIG FY P VL +TL TLP EL GMAEVIKY L D
Sbjct: 135 VDSSVGGKTAINHPLGKNMIGAFYQPQAVLADLDTLHTLPARELSAGMAEVIKYGALGDI 194
Query: 183 NVYRLLQDVKNVEEIRNREDI---IRESVNVKVRVVEEDLKESGKRRILNLGHTVGHAIE 239
+ L+ +RE + + +K +V +D E G R LNLGHT GHAIE
Sbjct: 195 GFFEWLEQHMPELMTLDREKLAQAVYRCCQMKADIVAQDETEQGIRAWLNLGHTFGHAIE 254
Query: 240 KLSGYKI-KHGFAVSVGLIAAAKLGEKLYN---FDSGKVIELVERFNLPTKLP-YPPKDI 294
GY HG A++ G + AA+L E+L D+ ++ L+E LP+ P + +
Sbjct: 255 TEMGYGTWLHGEAIAAGCVLAARLSEQLGKTSAADTARLAALLEAAGLPSAPPVFAFEKW 314
Query: 295 IEAMKLDKKAWYGKIVFVIPVEIGRISIEDVPEELLLQ 332
+E M DKK G + F+ +G +I ++ + +L+
Sbjct: 315 LEHMSHDKKVSGGIMRFIGLNRLGEANITEITDTDILR 352
>pir||S17768 3-dehydroquinate synthase (EC 4.6.1.3) aroB - Mycobacterium
tuberculosis (strain H37RV) >gi|48906|emb|CAA42095.1|
(X59509) ORF 1 [Mycobacterium tuberculosis]
Length = 362
Score = 187 bits (469), Expect = 2e-46
Identities = 113/272 (41%), Positives = 150/272 (54%), Gaps = 9/272 (3%)
Query: 51 GGDVFPIVIPDGEEYKTIETAIKIWDELVSFGFTRKSLLIGLGGGVITDIAGFVASTYMR 110
G D I IPD E K + IW+ L G RK+ L+ LGGG TD+AGF A+T++R
Sbjct: 63 GVDAHRIEIPDAEAGKDLPVVGFIWEVLGRIGIGRKNALVSLGGGAATDVAGFAAATWLR 122
Query: 111 GTLLGFIPTTLLAQVDAAIGGKTGVNFH-GKNMIGTFYLPNFVLISTETLSTLPRIELLN 169
G + +PTTLL VDAA+GGKTG+N GKN++G F+ P VL+ TL TLPR E++
Sbjct: 123 GVSIVHLPTTLLGMVDAAVGGKTGINTDAGKNLVGAFHQPLAVLVDLATLQTLPRDEMIC 182
Query: 170 GMAEVIKYAILDKNVYRLLQDVKNVEEIRNREDI----IRESVNVKVRVVEEDLKESGKR 225
GMAEV+K + V L + + D+ IR ++ VK VV D KES R
Sbjct: 183 GMAEVVKAGFIADPVILDLIEADPQAALDPAGDVLPELIRRAITVKAEVVAADEKESELR 242
Query: 226 RILNLGHTVGHAIEKLSGYKIKHGFAVSVGLIAAAKLGEKLYNFDSGKVIE---LVERFN 282
ILN GHT+GHAIE+ Y+ +HG AVSVGL+ AA+L D ++
Sbjct: 243 EILNYGHTLGHAIERRERYRWRHGAAVSVGLVFAAELARLAGRLDDATAQRHRTILSSLG 302
Query: 283 LPTKL-PYPPKDIIEAMKLDKKAWYGKIVFVI 313
LP P ++E M DKK G + FV+
Sbjct: 303 LPVSYDPDALPQLLEIMAGDKKTRAGVLRFVV 334
>sp|O50468|AROB_NEIGO 3-DEHYDROQUINATE SYNTHASE >gi|2661441|emb|CAA05722.1| (AJ002783)
3-dehydroquinate synthetase [Neisseria gonorrhoeae]
Length = 359
Score = 187 bits (469), Expect = 2e-46
Identities = 129/340 (37%), Positives = 186/340 (53%), Gaps = 20/340 (5%)
Query: 11 IFSPLSSLPSIVEELNPY---KIAVLTNDMLKSLWLDKI---IELLGGDVFPIVIPDGEE 64
IF LP L P+ + A++TN+ + L+L + ++ G F I++PDGE
Sbjct: 15 IFIGNGLLPQAGSLLKPHLGKRAAIITNETVAPLYLGTLQTALDAAGVSHFSIILPDGEA 74
Query: 65 YKTIETAIKIWDELVSFGFTRKSLLIGLGGGVITDIAGFVASTYMRGTLLGFIPTTLLAQ 124
+K +T I+D L+ RK+ LI LGGGVI D+ GF A+TY RG IPTTLL+Q
Sbjct: 75 HKNWQTLNLIFDGLMQNRAERKTTLIALGGGVIGDMVGFAAATYQRGAPFIQIPTTLLSQ 134
Query: 125 VDAAIGGKTGVNFH-GKNMIGTFYLPNFVLISTETLSTLPRIELLNGMAEVIKYAIL-DK 182
VD+++GGKT +N GKNMIG FY P VL +TL TLP EL GMAEVIKY L D
Sbjct: 135 VDSSVGGKTAINHPLGKNMIGAFYQPQAVLADLDTLHTLPARELSAGMAEVIKYGALGDI 194
Query: 183 NVYRLLQDVKNVEEIRNRE-----DIIRESVNVKVRVVEEDLKESGKRRILNLGHTVGHA 237
+ L+ +++ E+ E + +K +V +D E G R LNLGHT GHA
Sbjct: 195 GFFEWLE--QHMPELMTLERAPLTQAVYRCCQMKADIVAQDETEQGIRAWLNLGHTFGHA 252
Query: 238 IEKLSGYKI-KHGFAVSVGLIAAAKLGEKLYN---FDSGKVIELVERFNLPTKLP-YPPK 292
+E GY + HG AV+ G + AA+L E+L D+ ++ L+E LP+ P + +
Sbjct: 253 VEAEMGYGVWLHGEAVAAGCVLAARLSEQLGKTSAADTARLAALLEAAGLPSAPPVFAFE 312
Query: 293 DIIEAMKLDKKAWYGKIVFVIPVEIGRISIEDVPEELLLQ 332
+ M DKK G + F+ +G I ++ + +L+
Sbjct: 313 KWLAHMSHDKKVSGGIMRFIGLNRLGEAVITEITDTDILR 352
>sp|P36919|AROB_MYCTU 3-DEHYDROQUINATE SYNTHASE >gi|1781064|emb|CAB06200.1| (Z83863) aroB
[Mycobacterium tuberculosis]
Length = 362
Score = 186 bits (468), Expect = 3e-46
Identities = 113/272 (41%), Positives = 149/272 (54%), Gaps = 9/272 (3%)
Query: 51 GGDVFPIVIPDGEEYKTIETAIKIWDELVSFGFTRKSLLIGLGGGVITDIAGFVASTYMR 110
G D I IPD E K + IW+ L G RK L+ LGGG TD+AGF A+T++R
Sbjct: 63 GVDAHRIEIPDAEAGKDLPVVGFIWEVLGRIGIGRKDALVSLGGGAATDVAGFAAATWLR 122
Query: 111 GTLLGFIPTTLLAQVDAAIGGKTGVNFH-GKNMIGTFYLPNFVLISTETLSTLPRIELLN 169
G + +PTTLL VDAA+GGKTG+N GKN++G F+ P VL+ TL TLPR E++
Sbjct: 123 GVSIVHLPTTLLGMVDAAVGGKTGINTDAGKNLVGAFHQPLAVLVDLATLQTLPRDEMIC 182
Query: 170 GMAEVIKYAILDKNVYRLLQDVKNVEEIRNREDI----IRESVNVKVRVVEEDLKESGKR 225
GMAEV+K + V L + + D+ IR ++ VK VV D KES R
Sbjct: 183 GMAEVVKAGFIADPVILDLIEADPQAALDPAGDVLPELIRRAITVKAEVVAADEKESELR 242
Query: 226 RILNLGHTVGHAIEKLSGYKIKHGFAVSVGLIAAAKLGEKLYNFDSGKVIE---LVERFN 282
ILN GHT+GHAIE+ Y+ +HG AVSVGL+ AA+L D ++
Sbjct: 243 EILNYGHTLGHAIERRERYRWRHGAAVSVGLVFAAELARLAGRLDDATAQRHRTILSSLG 302
Query: 283 LPTKL-PYPPKDIIEAMKLDKKAWYGKIVFVI 313
LP P ++E M DKK G + FV+
Sbjct: 303 LPVSYDPDALPQLLEIMAGDKKTRAGVLRFVV 334
>pir||C82693 3-dehydroquinate synthase XF1334 [imported] - Xylella fastidiosa
(strain 9a5c) >gi|9106331|gb|AAF84143.1|AE003966_4
(AE003966) 3-dehydroquinate synthase [Xylella
fastidiosa]
Length = 394
Score = 183 bits (461), Expect = 2e-45
Identities = 119/293 (40%), Positives = 168/293 (56%), Gaps = 17/293 (5%)
Query: 59 IPDGEEYKTIETAIKIWDELVSFGFTRKSLLIGLGGGVITDIAGFVASTYMRGTLLGFIP 118
+P GE K++E +L + G TR + L LGGGVI D+AGF A+ +MRG +P
Sbjct: 76 LPAGETSKSLENFSAAIAQLATLGATRDACLFALGGGVIGDLAGFTAACWMRGIDYVQVP 135
Query: 119 TTLLAQVDAAIGGKTGVNF-HGKNMIGTFYLPNFVLISTETLSTLPRIELLNGMAEVIKY 177
TTLLA VD+++GGKT V+ GKNM+G F+ P V+ T+TL+TLP EL G++EVIKY
Sbjct: 136 TTLLAMVDSSVGGKTAVDIPQGKNMVGAFHPPRAVIADTDTLATLPLRELRAGLSEVIKY 195
Query: 178 -AILDKNVYRLLQDVKNVEEIRNREDI---IRESVNVKVRVVEEDLKESGKRRILNLGHT 233
AI D + LQ + R+ + I S K +V D E G+R +LNLGHT
Sbjct: 196 GAIRDPVFFHWLQTTREALLARDPAALAQAIARSCEHKADIVGRDPLEKGERVLLNLGHT 255
Query: 234 VGHAIEKLSGY------KIKHGFAVSVGLIAAAKLGEKLY---NFDSGKVIELVERFNLP 284
GHAIE GY + HG AV+VG++ AA+L L D+ + L++ + LP
Sbjct: 256 FGHAIETAQGYSTPGSNNLNHGEAVAVGMVLAARLSNALSLAPAQDTETLKNLLDAYGLP 315
Query: 285 TKLP--YPPKDIIEAMKLDKKAWYGKIVFVIPVEIGRI-SIEDVPEELLLQVL 334
T LP P+ ++E M+LDKK G++ V+ IG ++ DV E + Q+L
Sbjct: 316 TVLPSGLTPEMLLERMRLDKKNIAGRLRLVLWRGIGHAEAVSDVDEATVRQIL 368
>gb|AAC01717.1| (AF040570) aminodehydroquinate synthase [Amycolatopsis
mediterranei]
Length = 351
Score = 182 bits (457), Expect = 5e-45
Identities = 104/280 (37%), Positives = 160/280 (57%), Gaps = 17/280 (6%)
Query: 61 DGEEYKTIETAIKIWDELVSFGFTRKSLLIGLGGGVITDIAGFVASTYMRGTLLGFIPTT 120
DGE K + T ++ E FG TR +++ GGG TD+ G A+ Y RG + +PT+
Sbjct: 63 DGEPTKRLSTVEELCGEFARFGLTRSDVVVSCGGGTTTDVVGLAAALYHRGVAVVHLPTS 122
Query: 121 LLAQVDAAIGGKTGVNF-HGKNMIGTFYLPNFVLISTETLSTLPRIELLNGMAEVIKYAI 179
LLAQVDA++GGKT VN G+N++G ++ P+ VL T+ L+TLPR E+LNG+ E+ +
Sbjct: 123 LLAQVDASVGGKTAVNLPAGENLVGAYWQPSAVLCDTDYLTTLPRREVLNGLGEIARCHF 182
Query: 180 LDKNVYRLLQDVKNVEEIRNREDIIRESVNVKVRVVEEDLKESGKRRILNLGHTVGHAIE 239
+ D++ R+R + I SV +K +V +D +++G R +LN GHT+GHA+E
Sbjct: 183 IG------APDLRG----RSRPEQIAASVTLKAGIVAQDERDTGPRHLLNYGHTLGHALE 232
Query: 240 KLSGYKIKHGFAVSVGLIAAAKLGEKLYNFDSGKVIE---LVERFNLPTKLP--YPPKDI 294
+G+ ++HG AV++G + A +L L D V E +V + LP LP P +
Sbjct: 233 IATGFALRHGEAVAIGTVFAGRLAGALGRLDQSGVDEHLAVVRHYGLPAALPADVDPAVL 292
Query: 295 IEAMKLDKKAWYGKIVFVIPVEIGRISIEDVPEELLLQVL 334
+ M DKKA G + FV+ G + DVP ++ VL
Sbjct: 293 VRQMYRDKKAITG-LAFVLAGPRGAELVSDVPAPVVTDVL 331
>sp|P56081|AROB_HELPY 3-DEHYDROQUINATE SYNTHASE >gi|7437193|pir||C64555 3-dehydroquinate
synthase - Helicobacter pylori (strain 26695)
>gi|2313379|gb|AAD07351.1| (AE000547) 3-dehydroquinate
synthase (aroB) [Helicobacter pylori 26695]
Length = 343
Score = 178 bits (448), Expect = 6e-44
Identities = 119/317 (37%), Positives = 185/317 (57%), Gaps = 16/317 (5%)
Query: 29 KIAVLTNDMLKSLWLDKIIELLGG-DVFPIVIPDGEEYKTIETAIKIWDELVSFGFTRKS 87
K ++++ ++ L L ++E L +V VI GE+YK + +I + R S
Sbjct: 28 KALIISDSIVAGLHLPYLLERLKALEVRVCVIESGEKYKNFHSLERILNNAFEMQLNRHS 87
Query: 88 LLIGLGGGVITDIAGFVASTYMRGTLLGFIPTTLLAQVDAAIGGKTGVNF-HGKNMIGTF 146
L+I LGGGVI+D+ GF +S Y RG IPTTLLAQVDA++GGKTG+N +GKN+IG+F
Sbjct: 88 LMIALGGGVISDMVGFASSIYFRGIDFINIPTTLLAQVDASVGGKTGINTPYGKNLIGSF 147
Query: 147 YLPNFVLISTETLSTLPRIELLNGMAEVIKYAI-LDKNVYRLLQDVKNVEEIRNREDIIR 205
+ P V + L TL + E G+AE+IK A+ DKN+ L + K++++ E++I
Sbjct: 148 HQPKAVYMDLAFLKTLEKREFQAGVAEIIKMAVCFDKNLVERL-ETKDLKDC--LEEVIF 204
Query: 206 ESVNVKVRVVEEDLKESGKRRILNLGHTVGHAIEKLSGY-KIKHGFAVSVGLIAAAKLGE 264
+SVN+K +VV +D KE R LN GHT GHAIEK + Y + HG A+++G+ A L
Sbjct: 205 QSVNIKAQVVVQDEKEQNIRAGLNYGHTFGHAIEKETDYERFLHGEAIAIGMRMANDLAL 264
Query: 265 KLYNF---DSGKVIELVERFNLPTKLPYPPKDI---IEAMKLDKKAWYGKIVFVIPVEIG 318
L + ++ L+++F+L Y D+ E + LDKK+ I F++P +G
Sbjct: 265 SLGMLTLKEYERIENLLKKFDL--IFHYKILDLQKFYERLFLDKKSENKTIKFILPKGVG 322
Query: 319 RISI-EDVPEELLLQVL 334
+ +P+E +++VL
Sbjct: 323 AFEVASHIPKETIIKVL 339
>sp|Q9Z6M3|AROB_CHLPN 3-DEHYDROQUINATE SYNTHASE >gi|7437197|pir||H72003 dehyroquinate
synthase - Chlamydophila pneumoniae (strain CWL029)
>gi|4377369|gb|AAD19173.1| (AE001684) Dehyroquinate
Synthase [Chlamydophila pneumoniae CWL029]
>gi|8163505|gb|AAF73707.1| (AE002240) 3-dehydroquinate
synthase [Chlamydophila pneumoniae AR39]
>gi|8979409|dbj|BAA99243.1| (AP002548) dehyroquinate
synthase [Chlamydophila pneumoniae J138]
Length = 384
Score = 176 bits (442), Expect = 3e-43
Identities = 110/301 (36%), Positives = 166/301 (54%), Gaps = 25/301 (8%)
Query: 28 YKIAVLTNDMLKSLWLDKI---IELLGGDVFPIVIPDGEEYKTIETAIKIWDELVSFGFT 84
Y + ++T+ ++ L I I++LG V + P GE KT ET I + +LV +
Sbjct: 36 YPLVIITDVSVQQHLLGPILDHIKMLGYQVIVLTFPPGEPNKTWETFISLQYQLVDQNIS 95
Query: 85 RKSLLIGLGGGVITDIAGFVASTYMRGTLLGFIPTTLLAQVDAAIGGKTGVNFHG-KNMI 143
KS +IG+GGG + D+ GF+A+TY RG L IPTT+ A VD +IGGK G+N G KN +
Sbjct: 96 PKSSIIGIGGGTVLDMTGFLAATYCRGLPLYLIPTTITAMVDTSIGGKNGINLRGIKNRL 155
Query: 144 GTFYLPNFVLISTETLSTLPRIELLNGMAEVIKYA-ILDKNVYRLLQDVKNV--EEIRNR 200
GTFYLP V + + LSTLPR E +G+AE IK+ I D ++ L + +
Sbjct: 156 GTFYLPKEVWMCPQFLSTLPREEWYHGIAEAIKHGFIADAYLWEFLNSHSKMLFSSSQIL 215
Query: 201 EDIIRESVNVKVRVVEEDLKESGKRRILNLGHTVGHAIEKLSGYKIKHGFAVSVGLIAAA 260
+ I+ + +K +V ED + R+ILN GH++ HAIE L+ + HG AVSVG++
Sbjct: 216 HEFIKRNCQIKAAIVAEDPYDRSLRKILNFGHSIAHAIETLAKGTVNHGQAVSVGMMIET 275
Query: 261 KLGEKLYNFDSGKVIE----LVERFNLPTKLP--------------YPPKDIIEAMKLDK 302
++ + ++I+ L++RFNLP+ L Y P++II + DK
Sbjct: 276 RISLAEGVMKTPQLIDQLERLLKRFNLPSTLKDLQSIVPEHLHNSLYSPENIIYTLGYDK 335
Query: 303 K 303
K
Sbjct: 336 K 336
>emb|CAA72782.1| (Y12061) 3-dehydroquinate synthase [Helicobacter pylori]
Length = 343
Score = 175 bits (439), Expect = 7e-43
Identities = 121/317 (38%), Positives = 182/317 (57%), Gaps = 16/317 (5%)
Query: 29 KIAVLTNDMLKSLWLDKIIELLGG-DVFPIVIPDGEEYKTIETAIKIWDELVSFGFTRKS 87
K ++++ ++ L L ++E L +V VI GE+YK + + R S
Sbjct: 28 KALIISDSIVAGLHLSYLLERLKALEVRVCVIESGEKYKEFSFIRAHFKQRFEMQLNRHS 87
Query: 88 LLIGLGGGVITDIAGFVASTYMRGTLLGFIPTTLLAQVDAAIGGKTGVNF-HGKNMIGTF 146
L+I LGGGVI+D+ GF +S Y RG IPTTLLAQVDA++GGKTG+N +GKN+IG+F
Sbjct: 88 LMIALGGGVISDMVGFASSIYFRGIDFINIPTTLLAQVDASVGGKTGINTPYGKNLIGSF 147
Query: 147 YLPNFVLISTETLSTLPRIELLNGMAEVIKYAI-LDKNVYRLLQDVKNVEEIRNREDIIR 205
+ P V I L TL + E G+AE+IK A+ DKN+ L + K++E+ E++I
Sbjct: 148 HQPKAVYIDLAFLKTLEKREFQAGVAEIIKMAVCFDKNLVERL-ETKDLEDC--LEEVIF 204
Query: 206 ESVNVKVRVVEEDLKESGKRRILNLGHTVGHAIEKLSGY-KIKHGFAVSVGLIAAAKLGE 264
+SV +K +VV +D K+ R LN GHT GHAIEK + Y + HG A+++G+ A L
Sbjct: 205 QSVYIKAQVVVQDEKDQNIRAGLNYGHTFGHAIEKETDYERFLHGEAIAIGMRMANDLAL 264
Query: 265 KLYNF---DSGKVIELVERFNLPTKLPYPPKDI---IEAMKLDKKAWYGKIVFVIPVEIG 318
L + ++ L+++F+L Y DI E + LDKK+ I F++P IG
Sbjct: 265 SLGMLTLKEYERIENLLKKFDL--IFHYKITDIQKFYERLFLDKKSENKTIKFILPKGIG 322
Query: 319 RIS-IEDVPEELLLQVL 334
+ +P+E +L+VL
Sbjct: 323 AFEVVSHIPKETILKVL 339
>sp|Q9YEJ9|AROB_AERPE 3-DEHYDROQUINATE SYNTHASE >gi|7437196|pir||C72643 probable
3-dehydroquinate synthase APE0579 - Aeropyrum pernix
(strain K1) >gi|5104232|dbj|BAA79547.1| (AP000060) 358aa
long hypothetical 3-dehydroquinate synthase [Aeropyrum
pernix]
Length = 358
Score = 174 bits (437), Expect = 1e-42
Identities = 111/303 (36%), Positives = 162/303 (52%), Gaps = 10/303 (3%)
Query: 43 LDKIIELLGGDVFPIVIPDGEEYKTIETAIKIWDELVSFGFTRKSLLIGLGGGVITDIAG 102
L +I+E G +V V GE K+++ ++WD ++ G R + + +GGG + D AG
Sbjct: 54 LARILEARGVEVLGAVAGGGERVKSLDWVTRLWDLMLQAGVERSTTVYIIGGGALLDAAG 113
Query: 103 FVASTYMRGTLLGFIPTTLLAQVDAAIGGKTGVNFHGKNMIGTFYLPNFVLISTETLSTL 162
F AST MRG IP+T LA DAA GGKTGVN GKNM+GTF+ P VL+ ++
Sbjct: 114 FAASTLMRGLSTVNIPSTTLAAFDAAAGGKTGVNLRGKNMVGTFHNPRMVLVEPGIVAGQ 173
Query: 163 PRIELLNGMAEVIKYAIL--DKNVYRLLQDVKNVEEIRNREDIIRESVNVKVRVVEEDLK 220
P +G AE++K+ L D+ L + S+ K++VV D +
Sbjct: 174 PDEGYRDGFAELVKHVALSGDREPAASLLPQALARRPAPLARLAFWSLGYKMQVVAGDPR 233
Query: 221 ESGKRRILNLGHTVGHAIEKLSGYKIKHGFAVSVGLIAAAKLGEKLYNFDSGK---VIEL 277
E G RRILNLGHT+GHA+E S Y + HG +VS+GL +L +L G+ V+++
Sbjct: 234 ERGLRRILNLGHTIGHALEAASSYTLSHGRSVSIGLAGELELSRRLAGLPRGEAEDVLDM 293
Query: 278 VERFNLPTKLPYPPKDIIEA---MKLDKKAWYGKIVFVIPVEIGRISIEDVPEELLLQVL 334
+ LP L PP EA + LDKK G IV + +GR + VP E + +++
Sbjct: 294 LSTAGLP--LEPPPGLAGEAAGLVGLDKKREGGSIVMPLLERLGRPRLSRVPVETVSRLM 351
Query: 335 GEI 337
E+
Sbjct: 352 VEL 354
>gb|AAD28456.1|AF127374_11 (AF127374) MitP [Streptomyces lavendulae]
Length = 343
Score = 174 bits (436), Expect = 2e-42
Identities = 109/326 (33%), Positives = 171/326 (52%), Gaps = 29/326 (8%)
Query: 18 LPSIVEELNPYKIAVLTN---DMLKSLWLDKIIELLGGDVFPIVIPDGEEYKTIETAIKI 74
LP IV L ++ AV+T D++ + +I + DGE +KT+ T +
Sbjct: 30 LPGIVASLGAHRAAVVTARPPDLVPDPGVPALI---------VRARDGERHKTLATVEDL 80
Query: 75 WDELVSFGFTRKSLLIGLGGGVITDIAGFVASTYMRGTLLGFIPTTLLAQVDAAIGGKTG 134
+ +FG TR +++ GGG TD G A+ + RG + +PTTLLAQVDA++GGKT
Sbjct: 81 CRKFTTFGITRHDVVVSCGGGSTTDTVGLAAALHHRGVPVVHLPTTLLAQVDASVGGKTA 140
Query: 135 VNF-HGKNMIGTFYLPNFVLISTETLSTLPRIELLNGMAEVIKYAILDKNVYRLLQDVKN 193
VN GKN++G ++ P VL T L TLP E +NG E+ + + R L
Sbjct: 141 VNLPEGKNLVGAYWQPKAVLCDTTYLQTLPAEEWVNGYGEIARCHFIGAGDLRGLA---- 196
Query: 194 VEEIRNREDIIRESVNVKVRVVEEDLKESGKRRILNLGHTVGHAIEKLSGYKIKHGFAVS 253
D + S+ +K VV D +++G R ILN GHT+GHA+E +G+ ++HG V+
Sbjct: 197 ------VHDQVTASLRLKASVVAADERDTGLRHILNYGHTLGHALETATGFGLRHGLGVA 250
Query: 254 VGLIAAAKLGEKLYNFDSGKV---IELVERFNLPTKLP--YPPKDIIEAMKLDKKAWYGK 308
+G + A +L E L + + E+V + LP LP +++ M+ DKKA G
Sbjct: 251 IGTVFAGRLAEALGRIGADRAREHTEVVRHYGLPDSLPGNTDITELVALMRHDKKATSG- 309
Query: 309 IVFVIPVEIGRISIEDVPEELLLQVL 334
+ FV+ G + +PE+++L+ L
Sbjct: 310 LTFVLDGPSGVELVSGIPEDVVLRTL 335
>sp|Q9ZMF2|AROB_HELPJ 3-DEHYDROQUINATE SYNTHASE >gi|7437192|pir||E71952 3-dehydroquinate
synthase - Helicobacter pylori (strain J99)
>gi|4154792|gb|AAD05849.1| (AE001464) 3-DEHYDROQUINATE
SYNTHASE [Helicobacter pylori J99]
Length = 343
Score = 173 bits (434), Expect = 3e-42
Identities = 118/317 (37%), Positives = 182/317 (57%), Gaps = 16/317 (5%)
Query: 29 KIAVLTNDMLKSLWLDKIIELLGG-DVFPIVIPDGEEYKTIETAIKIWDELVSFGFTRKS 87
K ++++ ++ L L ++E L +V VI GE+YK + +I + R S
Sbjct: 28 KALIISDSIVAGLHLPYLLERLNALEVRVCVIESGEKYKNFHSLERILNNAFEMQLNRHS 87
Query: 88 LLIGLGGGVITDIAGFVASTYMRGTLLGFIPTTLLAQVDAAIGGKTGVNF-HGKNMIGTF 146
L+I LGGGVI+D+ GF +S Y RG IPTTLLAQVDA++GGKTG+N +GKN+IG+F
Sbjct: 88 LMIALGGGVISDMVGFASSIYFRGIDFINIPTTLLAQVDASVGGKTGINTPYGKNLIGSF 147
Query: 147 YLPNFVLISTETLSTLPRIELLNGMAEVIKYAI-LDKNVYRLLQDVKNVEEIRNREDIIR 205
+ P V + L TL + E G+AE+IK A+ DKN+ L + K++++ E++I
Sbjct: 148 HQPKAVYMDLAFLKTLEKREFQAGVAEIIKMAVCFDKNLVERL-ETKDLKDC--LEEVIF 204
Query: 206 ESVNVKVRVVEEDLKESGKRRILNLGHTVGHAIEKLSGY-KIKHGFAVSVGLIAAAKLGE 264
+SVN+K +VV +D KE R LN GHT G IE + Y + HG A+++G+ A L
Sbjct: 205 QSVNIKAQVVVQDEKERNIRAGLNYGHTFGMLIENETNYERFLHGEAIAIGMRMANDLAL 264
Query: 265 KLYNF---DSGKVIELVERFNLPTKLPYPPKDI---IEAMKLDKKAWYGKIVFVIPVEIG 318
L + ++ L+++F+L Y DI E + LDKK+ + F++P +G
Sbjct: 265 SLGMLTLKEYERIENLLKKFDL--IFNYQITDIQKFYERLFLDKKSENQTLKFILPKGVG 322
Query: 319 RISI-EDVPEELLLQVL 334
I +P+E +L+VL
Sbjct: 323 AFEIASHIPKETILKVL 339
>sp|Q9WYI3|ARKB_THEMA BIFUNCTIONAL SHIKIMATE KINASE/3-DEHYDROQUINATE SYNTHASE [INCLUDES:
SHIKIMATE KINASE (SK); 3-DEHYDROQUINATE SYNTHASE ]
>gi|7462950|pir||B72389 shikimate
kinase/3-dehydroquinate synthase - Thermotoga maritima
(strain MSB8) >gi|4980849|gb|AAD35434.1|AE001715_10
(AE001715) shikimate kinase/3-dehydroquinate synthase
[Thermotoga maritima]
Length = 492
Score = 173 bits (433), Expect = 3e-42
Identities = 112/303 (36%), Positives = 165/303 (53%), Gaps = 22/303 (7%)
Query: 47 IELLGGDVFP---IVIPDGEEYKTIETAIKIWDELVSFGFTRKSLLIGLGGGVITDIAGF 103
+E + G P ++ PDGEE KT+E + + EL+ F R + G+GGG +TD GF
Sbjct: 196 VEKIYGRYLPENRLLFPDGEEVKTLEHVSRAYYELIRMDFPRGKTIAGVGGGALTDFTGF 255
Query: 104 VASTYMRGTLLGFIPTTLLAQVDAAIGGKTGVNFHG-KNMIGTFYLPNFVLISTETLSTL 162
VAST+ RG L F PTTLLAQVDA++GGK ++F G KN++GTF +P++V+I ++
Sbjct: 256 VASTFKRGVGLSFYPTTLLAQVDASVGGKNAIDFAGVKNVVGTFRMPDYVIIDPTVTLSM 315
Query: 163 PRIELLNGMAEVIKYAILDKNVYRLLQDVKNVEE--IRNREDIIRESVNVKVRVVEEDLK 220
G+ E K IL L + + +E+ +R ++++ SV K R+V ED
Sbjct: 316 DEGRFEEGVVEAFKMTILSGRGVELFDEPEKIEKRNLRVLSEMVKISVEEKARIVMEDPY 375
Query: 221 ESGKRRILNLGHTVGHAIEKLSGYKIKHGFAVSVGLIAAAKLGEKLYNFDSGKVIE---- 276
+ G R LNLGHT+GH E L G + HG AV+ G+ E +Y + G V +
Sbjct: 376 DMGLRHALNLGHTLGHVYEMLEG--VPHGIAVAWGIEK-----ETMYLYRKGIVPKETMR 428
Query: 277 -LVERFNLPTKLPYPPKDIIEAMKL---DKKAWYGKIVFVIPV-EIGRISIEDVPEELLL 331
+VE+ +P P D+ +A L DKK G V + V EIG+I +V LL
Sbjct: 429 WIVEKVKQIVPIPVPSVDVEKARNLILNDKKILKGSRVRLPYVKEIGKIEFLEVDPLELL 488
Query: 332 QVL 334
+V+
Sbjct: 489 EVV 491
>emb|CAC11430.1| (AL445063) 3-dehyroquinate synthase related protein [Thermoplasma
acidophilum]
Length = 360
Score = 170 bits (427), Expect = 2e-41
Identities = 115/337 (34%), Positives = 177/337 (52%), Gaps = 27/337 (8%)
Query: 2 EGIAHMENIIFSPLSSLPSIVEELNPYKIAVLTNDMLKSLWLDKIIELLGGDVFPIVIPD 61
E + H ++++F + VEE+ KI L N G I + D
Sbjct: 29 EEVGHYDSLVFM----ISRNVEEMFGSKIPPLEN--------------YGSSTIKITLND 70
Query: 62 GEEYKTIETAIKIWDELVSFGFTRKSLLIGLGGGVITDIAGFVASTYMRGTLLGFIPTTL 121
GE KT+ +I LV +R SLL+ +GGG + D+AGFVA+TY RG + +PTTL
Sbjct: 71 GESLKTLRNYQRIIKVLVEKKVSRNSLLVYVGGGTVGDLAGFVAATYKRGLRMIAVPTTL 130
Query: 122 LAQVDAAIGGKTGVNFHG-KNMIGTFYLPNFVLISTETLSTLPRIELLNGMAEVIKYAIL 180
LAQVD++IGGK G++F KN+IGTFY P ++ + L + P + + GM EVIKY+I+
Sbjct: 131 LAQVDSSIGGKNGLDFSDVKNVIGTFYNPYLIIDDLQFLKSTPDL-IREGMGEVIKYSII 189
Query: 181 -DKNVYRLLQDVKNVEEIRNREDIIRESVNVKVRVVEEDLKE-SGKRRILNLGHTVGHAI 238
+++R + + + DI++ S+ +K +V D + +G R ILNLGHT+ H I
Sbjct: 190 AGGDMFRKVSECSLSNFHDHSADIVKMSIKIKADIVNRDYYDRNGVRSILNLGHTIAHGI 249
Query: 239 EKLSGYKIKHGFAVSVGLIAAAKLGEKLYNFDS---GKVIELVERFNLPTK--LPYPPKD 293
E S +I HG AV+ GL+ A +GEK N ++++L + + +
Sbjct: 250 EGASKGQISHGRAVATGLMVEAHIGEKYGNTRPEVIDEIMKLADNYGIERVRISDIGVNS 309
Query: 294 IIEAMKLDKKAWYGKIVFVIPVEIGRISIEDVPEELL 330
I+ + DKK G I +P +IG I V E ++
Sbjct: 310 ILRYISNDKKMSEGYINMPVPADIGNIITMKVTERMI 346
>gb|AAC14006.1| (U33059) aminodehydroquinate synthase [Actinosynnema pretiosum
subsp. auranticum]
Length = 342
Score = 169 bits (424), Expect = 4e-41
Identities = 102/286 (35%), Positives = 154/286 (53%), Gaps = 19/286 (6%)
Query: 57 IVIP--DGEEYKTIETAIKIWDELVSFGFTRKSLLIGLGGGVITDIAGFVASTYMRGTLL 114
+V+P DGE KT+ T + FG TR +++ GGG TD G AS Y RGT +
Sbjct: 62 LVLPARDGEHDKTLATVAHLCSRFAEFGLTRADVVVSCGGGTTTDAVGLAASLYHRGTPV 121
Query: 115 GFIPTTLLAQVDAAIGGKTGVNF-HGKNMIGTFYLPNFVLISTETLSTLPRIELLNGMAE 173
+PT+LLAQVDA++GGKT VN GKN++G+++ P VL + L+TLP EL NG+ E
Sbjct: 122 VHVPTSLLAQVDASVGGKTAVNLPEGKNLVGSYWQPAAVLCDLDLLATLPERELRNGLGE 181
Query: 174 VIKYAILDKNVYRLLQDVKNVEEIRNREDIIRESVNVKVRVVEEDLKESGKRRILNLGHT 233
+ + + L + D + SV +K RVV D ++ G R LN GHT
Sbjct: 182 IARCHFIGAPGLDRLPLL----------DQVAASVALKARVVAADERDRGLRHTLNYGHT 231
Query: 234 VGHAIEKLSGYKIKHGFAVSVGLIAAAKLGEKLYNFDSGKVIE---LVERFNLPTKLP-- 288
+GHA+E +G+ ++HG V++G + A +L L +V E +V + LP LP
Sbjct: 232 LGHALELATGFAVRHGEGVAIGTVFAGRLAGALGRIGPDRVAEHHAVVAGYGLPVALPPG 291
Query: 289 YPPKDIIEAMKLDKKAWYGKIVFVIPVEIGRISIEDVPEELLLQVL 334
P +++ ++ DKK+ G + FV+ G + DV E ++ L
Sbjct: 292 VPDDELLRFVRRDKKS-TGGLAFVLDGPRGAELVRDVDEHVVAATL 336
>pir||B75478 3-dehydroquinate synthase - Deinococcus radiodurans (strain R1)
>gi|6458486|gb|AAF10353.1|AE001932_5 (AE001932)
3-dehydroquinate synthase [Deinococcus radiodurans]
Length = 350
Score = 168 bits (420), Expect = 1e-40
Identities = 101/277 (36%), Positives = 149/277 (53%), Gaps = 3/277 (1%)
Query: 57 IVIPDGEEYKTIETAIKIWDELVSFGFTRKSLLIGLGGGVITDIAGFVASTYMRGTLLGF 116
+ +P +E KT+E + +L G R ++GLGGG TD+AGFVA++Y+RG
Sbjct: 57 VTVPARDECKTLEVFADVLSQLAQAGLPRSGAVVGLGGGAATDLAGFVAASYLRGVAFYT 116
Query: 117 IPTTLLAQVDAAIGGKTGVNF-HGKNMIGTFYLPNFVLISTETLSTLPRIELLNGMAEVI 175
PTTLL VDAA+GGKTGVN GKN++G F+ P V T TL+TLP G AE
Sbjct: 117 APTTLLGMVDAAVGGKTGVNLPEGKNLVGAFWPPRAVWCDTATLTTLPDAVFREGAAEAF 176
Query: 176 KYAIL-DKNVYRLLQDVKNVEEIRNREDIIRESVNVKVRVVEEDLKESGKRRILNLGHTV 234
K+ ++ D ++ + ED + +++ VK VV DL E G+R LN GHT+
Sbjct: 177 KHGLMADPSLLDRVVSPDFRPGGALLEDTLADAIAVKAGVVTRDLTEQGERAFLNFGHTL 236
Query: 235 GHAIEKLSGYKIKHGFAVSVGLIAAAKLGEKLYNFDSGKVIELVERFNLPTKLPYPPKDI 294
HA+E ++ I HG AV+ G+ AA+L L D R+ P +LP D
Sbjct: 237 AHALEAVTHQAIPHGEAVAYGMHYAARLSHALGGADLTAHTRAFLRWQRPRRLPPLTFDA 296
Query: 295 IEA-MKLDKKAWYGKIVFVIPVEIGRISIEDVPEELL 330
+ + DKKA + FV+ ++ + + VP+++L
Sbjct: 297 LAPFIARDKKADSAGVRFVLLRDLAQPYLARVPDDVL 333
>gi|6320332 pentafunctional arom polypeptide (contains: 3-dehydroquinate
synthase, 3-dehydroquinate dehydratase
(3-dehydroquinase), shikimate 5-dehydrogenase, shikimate
kinase, and epsp synthase); Aro1p [Saccharomyces
cerevisiae] >gi|114166|sp|P08566|ARO1_YEAST
PENTAFUNCTIONAL AROM POLYPEPTIDE [INCLUDES:
3-DEHYDROQUINATE SYNTHASE ; 3-DEHYDROQUINATE DEHYDRATASE
(3-DEHYDROQUINASE); SHIKIMATE 5-DEHYDROGENASE ;
SHIKIMATE KINASE ; 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSFERASE
(5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYN>
>gi|66631|pir||BVBYA1 ARO1 protein - yeast
(Saccharomyces cerevisiae) >gi|3381|emb|CAA29458.1|
(X06077) arom multifunctional enzyme (AA 1-1588)
[Saccharomyces cerevisiae] >gi|665659|emb|CAA88208.1|
(Z48179) Aro1p [Saccharomyces cerevisiae]
Length = 1588
Score = 161 bits (403), Expect = 1e-38
Identities = 107/317 (33%), Positives = 161/317 (50%), Gaps = 49/317 (15%)
Query: 51 GGDVFPIVIPDGEEYKTIETAIKIWDELVSFGFTRKSLLIGLGGGVITDIAGFVASTYMR 110
G + V+ GE K+ ET ++ D L+ G TR ++++ +GGGVI D+ GFVAST+MR
Sbjct: 66 GSRLLTYVVKPGETSKSRETKAQLEDYLLVEGCTRDTVMVAIGGGVIGDMIGFVASTFMR 125
Query: 111 GTLLGFIPTTLLAQVDAAIGGKTGVNFH-GKNMIGTFYLPNFVLISTETLSTLPRIELLN 169
G + +PT+LLA VD++IGGKT ++ GKN IG F+ P FVL+ + L TL + E +N
Sbjct: 126 GVRVVQVPTSLLAMVDSSIGGKTAIDTPLGKNFIGAFWQPKFVLVDIKWLETLAKREFIN 185
Query: 170 GMAEVIKYAIL----------------------DKNVYRLLQDVKNVEEIRNRE------ 201
GMAEVIK A + KNV Q ++EI N +
Sbjct: 186 GMAEVIKTACIWNADEFTRLESNASLFLNVVNGAKNVKVTNQLTNEIDEISNTDIEAMLD 245
Query: 202 ---DIIRESVNVKVRVVEEDLKESGKRRILNLGHTVGHAIEKLSGYKIKHGFAVSVGLIA 258
++ ES+ VK VV D +ES R +LN GH++GHA E + + HG VS+G++
Sbjct: 246 HTYKLVLESIKVKAEVVSSDERESSLRNLLNFGHSIGHAYEAILTPQALHGECVSIGMVK 305
Query: 259 AAKLGEKLYNFDSGKVIELVERFNLPTKLPYPPKD----------------IIEAMKLDK 302
A+L + + S + + + + LP P + +++ M +DK
Sbjct: 306 EAEL-SRYFGILSPTQVARLSKILVAYGLPVSPDEKWFKELTLHKKTPLDILLKKMSIDK 364
Query: 303 KAWYGKIVFVIPVEIGR 319
K K VI IG+
Sbjct: 365 KNEGSKKKVVILESIGK 381
>gb|AAF05326.1| (AF181869) 3-dehydroquinate synthetase homolog [Legionella
pneumophila]
Length = 192
Score = 161 bits (403), Expect = 1e-38
Identities = 93/183 (50%), Positives = 119/183 (64%), Gaps = 6/183 (3%)
Query: 89 LIGLGGGVITDIAGFVASTYMRGTLLGFIPTTLLAQVDAAIGGKTGVNF-HGKNMIGTFY 147
+I LGGGVI D+AGF ASTY RG +PTTLLAQVDA++GGKT +N GKNMIG+FY
Sbjct: 2 IIALGGGVIGDMAGFAASTYQRGVRFIQLPTTLLAQVDASVGGKTAINHPAGKNMIGSFY 61
Query: 148 LPNFVLISTETLSTLPRIELLNGMAEVIKYAIL-DKNVYRLLQDVKNVEEIRNRED---I 203
P V+I TL TLP E G+AE+IKYA+L + + +QDV + + +
Sbjct: 62 QPQAVIIDLNTLKTLPEREFRAGIAEMIKYALLVGGSFFERIQDVLQQGLTVHSPELPLL 121
Query: 204 IRESVNVKVRVVEEDLKESGKRRILNLGHTVGHAIEKLSGY-KIKHGFAVSVGLIAAAKL 262
I E VK ++VE+D +ESG R +LNLGHT HA+E + Y K HG AV++GL AA L
Sbjct: 122 IAECCQVKAKIVEQDERESGLRALLNLGHTFAHALETYTDYKKWLHGEAVAIGLYCAAVL 181
Query: 263 GEK 265
EK
Sbjct: 182 SEK 184
>gb|AAC35272.1| (AF053071) dehydroquinate synthetase [Corynebacterium glutamicum]
Length = 360
Score = 160 bits (400), Expect = 3e-38
Identities = 113/301 (37%), Positives = 165/301 (54%), Gaps = 17/301 (5%)
Query: 43 LDKIIELLGGDVFPIVIPDGEEYKTIETAIKIWDELVSFGFTRKSLLIGLGGGVITDIAG 102
LD+ + G V + +PD E K++E A ++ L F R+ ++IGLGGG TD+AG
Sbjct: 56 LDRALVAAGLKVLHLNVPDAENGKSLEVAGQV---LGGAAFGRRDIVIGLGGGAATDLAG 112
Query: 103 FVASTYMRGTLLGFIPTTLLAQVDAAIGGKTGVNFH-GKNMIGTFYLPNFVLISTETLST 161
FVA+ +MRG + +PTTLLA VDAA+GGKTG+N GKN++G F+ P+ V I T+ L+T
Sbjct: 113 FVAAAWMRGVGVIQVPTTLLAMVDAAVGGKTGINTRAGKNLVGAFHEPDAVFIDTDRLAT 172
Query: 162 LPRIELLNGMAEVIKYA-ILDKNVYRLLQD-----VKNVEEIRNREDIIRESVNVKVRVV 215
LP E++ G AE+IK I D + RL + +K E + ++I SV VK VV
Sbjct: 173 LPDAEIIAGSAEIIKTGFIADPEILRLYETDPAACLKKEVEGSHLPELIWRSVTVKGSVV 232
Query: 216 EEDLKESGKRRILNLGHTVGHAIEKLSGYKIKHGFAVSVGLIAAAKLGEKLYNFDS---G 272
+D K ILN GHT HA+E ++ +HG S G++ A L KL D+
Sbjct: 233 GQDSKNLA-CEILNYGHTFAHAVELRENFRWRHGNVCS-GMMFIANLSHKLGLIDAPLLE 290
Query: 273 KVIELVERFNLPTKLPYPPKD-IIEAMKLDKKAWYGKIVFVIPVEIGRISIEDVPEELLL 331
+ ++ LPT D + + M DKK G I FV + +G ++ + P + L
Sbjct: 291 RHRSILAAIGLPTSYEGGAFDELYDGMTRDKKNRDGNIRFV-ALTVGEVTRIEGPSKQDL 349
Query: 332 Q 332
Q
Sbjct: 350 Q 350
>gb|AAD31825.1| (AF131877) aminodehydroquinate synthase [Streptomyces collinus]
Length = 358
Score = 157 bits (392), Expect = 2e-37
Identities = 102/298 (34%), Positives = 155/298 (51%), Gaps = 22/298 (7%)
Query: 16 SSLPSIVEELNPYKIAVLTNDMLKSLWLDKIIELLGGDVFPIVIPDGEEYKTIETAIKIW 75
S+LP I+ L ++AV++ + W+ G + + DGE +
Sbjct: 24 SALPGIIGRLGARRVAVVSARPPE--WVPDT----GAETLLLPARDGEPDTDARHGGVLC 77
Query: 76 DELVSFGFTRKSLLIGLGGGVITDIAGFVASTYMRGTLLGFIPTTLLAQVDAAIGGKTGV 135
V FG TR ++ +GGG TD+ G A+ Y RG + +PTTLLAQVDA++GGKT V
Sbjct: 78 AAFVRFGLTRSDAVVSVGGGTTTDVVGLAAALYHRGIPVVHLPTTLLAQVDASVGGKTAV 137
Query: 136 NF-HGKNMIGTFYLPNFVLISTETLSTLPRIELLNGMAEVIKYAILDKNVYRLLQDVKNV 194
N GKN++G ++ P VL T+ L+TLP EL NG+ E+ + + L +
Sbjct: 138 NLPEGKNLVGAYWQPAAVLCDTDYLTTLPPRELRNGLGEIARCHFIGAPG---LHGLPLA 194
Query: 195 EEIRNREDIIRESVNVKVRVVEEDLKESGKRRILNLGHTVGHAIEKLSGYKIKHGFAVSV 254
E+ I SV +K +V D +++G R +LN GHT+GHA+E +G+ ++HG V++
Sbjct: 195 EQ-------IAASVTLKAGIVSADERDTGLRHLLNYGHTLGHALEAATGFALRHGEGVAI 247
Query: 255 GLIAAAKLGEKLYNFDSGKVIE---LVERFNLPTKLP--YPPKDIIEAMKLDKKAWYG 307
G + A L L +V E V + +PT LP P +IE M+ D+KA G
Sbjct: 248 GTVFAGLLAGLLGRIGPDRVSEHRAHVASYGVPTALPDDADPGTLIEVMRRDEKARSG 305
>sp|Q12659|ARO1_PNECA PENTAFUNCTIONAL AROM POLYPEPTIDE [INCLUDES: 3-DEHYDROQUINATE
SYNTHASE ; 3-DEHYDROQUINATE DEHYDRATASE
(3-DEHYDROQUINASE); SHIKIMATE 5-DEHYDROGENASE ;
SHIKIMATE KINASE ; 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSFERASE
(5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYN>
>gi|7489936|pir||T30832 pentafunctional enzyme -
Pneumocystis carinii >gi|475972|gb|AAA17839.1| (L18918)
pentafunctional enzyme [Pneumocystis carinii]
Length = 1581
Score = 155 bits (389), Expect = 5e-37
Identities = 101/281 (35%), Positives = 153/281 (53%), Gaps = 36/281 (12%)
Query: 59 IPDGEEYKTIETAIKIWDELVSFGFTRKSLLIGLGGGVITDIAGFVASTYMRGTLLGFIP 118
IP GE+ K+ +T I D L+S TR +++I +GGGVI D+ G+V++T+MRG IP
Sbjct: 76 IPPGEKSKSRKTKALIEDWLLSEKCTRDTVIIAIGGGVIGDLVGYVSATFMRGVRFIQIP 135
Query: 119 TTLLAQVDAAIGGKTGVN-FHGKNMIGTFYLPNFVLISTETLSTLPRIELLNGMAEVIKY 177
TTLLA VD++IGGK +N +GKN IGT + P + I L TL E +NG+AE+IK
Sbjct: 136 TTLLAMVDSSIGGKNSINTSYGKNAIGTIWQPERIFIDFTFLETLTEKEFINGIAELIKT 195
Query: 178 AIL-DKNVYRLLQDV-------------------KNVEEIRNREDIIRESVNVKVRVVEE 217
I+ D++ + L+++ K E I++ + I S+ +K +V
Sbjct: 196 IIIWDESEFASLENISEKIAKTVRSMSLTSNKHSKFNEIIKDLKRYIISSIKIKAHIVSI 255
Query: 218 DLKESGKRRILNLGHTVGHAIEKLSGYKIKHGFAVSVGLIAAAKLGEKLYNFDSGKVIEL 277
D KE R +LN GH++GHAIE + I HG ++S+G++ A+L L + V L
Sbjct: 256 DEKEKDLRTLLNFGHSIGHAIETVLAPYILHGESISIGMVKEAELSRHLGILNPNVVSRL 315
Query: 278 VERFN---LPTKL------------PYPPKDIIEAMKLDKK 303
++ N LPT + +DI+E M +DKK
Sbjct: 316 IKCLNTWGLPTSFKDRRFKEVILGKKHLIEDILEIMSIDKK 356
>emb|CAA40251.1| (X56928) ORF2~gtg start codon [Actinoplanes teichomyceticus]
Length = 329
Score = 155 bits (388), Expect = 7e-37
Identities = 95/260 (36%), Positives = 144/260 (54%), Gaps = 18/260 (6%)
Query: 61 DGEEYKTIETAIKIWDELVSFGFTRKSLLIGLGGGVITDIAGFVASTYMRGTLLGFIPTT 120
DGE KT+ + FG +R +++ +GGG TD AG A+ Y RG + +PTT
Sbjct: 48 DGEAGKTLSVVERYCRRFAQFGLSRTDVVVAVGGGSTTDTAGLAAALYHRGVPVIHLPTT 107
Query: 121 LLAQVDAAIGGKTGVNF-HGKNMIGTFYLPNFVLISTETLSTLPRIELLNGMAEVIKYAI 179
LLAQVDA++GGKTG N GKN++G ++ P VL T+ L+TL EL +G E+ +
Sbjct: 108 LLAQVDASVGGKTGANLPEGKNLVGAYWQPRAVLCDTDYLATLSAAELRSGYGEIARCHF 167
Query: 180 LDKNVYRLLQDVKNVEEIRNREDIIRESVNVKVRVVEEDLKE-SGKRRILNLGHTVGHAI 238
+ D++ R+ + I SV K +V D +E SG+R +LN GHT+GHA+
Sbjct: 168 IGAG------DLRG----RSHTEQIAASVRRKAELVSADERESSGRRHLLNYGHTLGHAL 217
Query: 239 EKLSGYKIKHGFAVSVGLIAAAKLGEKLYNFDSGKV---IELVERFNLPTKLP--YPPKD 293
E +G+ ++HG AV++G + A +L L +V E+V + L +LP P
Sbjct: 218 EVGTGFTLRHGEAVAIGTVFAGRLAGHLGRITPERVAEHAEVVAHYGLSGRLPSGVDPAA 277
Query: 294 IIEAMKLDKKAWYGKIVFVI 313
++ M+ DKKA G + FV+
Sbjct: 278 LLALMRRDKKATTG-LTFVL 296
>pir||T50113 pentafunctional enzyme arom [imported] - fission yeast
(Schizosaccharomyces pombe) >gi|7019762|emb|CAB75770.1|
(AL157734) pentafunctional arom polypeptide [includes
3-dehydroquinate synthase](ec 4.6.1.3); 3-dehydroquinate
dehydratase [Schizosaccharomyces pombe]
Length = 1573
Score = 155 bits (388), Expect = 7e-37
Identities = 111/341 (32%), Positives = 172/341 (49%), Gaps = 43/341 (12%)
Query: 21 IVEELNPYKIAVLTNDMLKSLWLDKIIELLGGDV---------FPIVIPDGEEYKTIETA 71
I+E V+T+ + L+L+KI + VIP GE K
Sbjct: 32 ILENFKSSTYVVITDSNIAPLYLEKIESTFNKSIKDAKAEARLLTYVIPPGESSKCRAMK 91
Query: 72 IKIWDELVSFGFTRKSLLIGLGGGVITDIAGFVASTYMRGTLLGFIPTTLLAQVDAAIGG 131
+I D L++ TR ++LI +GGGVI D+ G+VA+++MRG +PTTLLA VD++IGG
Sbjct: 92 AEIEDWLLTQSCTRDTILIAMGGGVIGDLVGYVAASFMRGIRFIQMPTTLLAMVDSSIGG 151
Query: 132 KTGVNFH-GKNMIGTFYLPNFVLISTETLSTLPRIELLNGMAEVIKYAIL-DKNVYRLLQ 189
KTG++ GKN++G F+ P V + L TLP +++NG++E+IK A + ++N ++LL+
Sbjct: 152 KTGIDTPLGKNLVGAFWQPLRVYVDMVFLHTLPPRQVINGLSEIIKTAAMWNENDFQLLE 211
Query: 190 -------DVKNVEEIRNR----------EDIIRESVNVKVRVVEEDLKESGKRRILNLGH 232
D N + + II S+ K VV D E G R +LN GH
Sbjct: 212 NNSAVLLDALNKPSVPGEYKFDSIKPLLQKIILSSIRTKCEVVTLDEHEGGLRNLLNFGH 271
Query: 233 TVGHAIEKLSGYKIKHGFAVSVGLIAAAKLGEKLYNFDS---GKVIELVERFNLPTKL-- 287
++GHA E + +I HG V++G++ A+L L G++ + + +NLP +
Sbjct: 272 SIGHAYEAILYPQILHGECVAIGMVKEAELARYLGILKPNAVGRLTKCLVSYNLPISVND 331
Query: 288 ----------PYPPKDIIEAMKLDKKAWYGKIVFVIPVEIG 318
P + +IE M +DKK K VI IG
Sbjct: 332 PKVKKYASFKHCPVEKLIEYMAVDKKNQGSKKRIVILKAIG 372
>pir||BVASA1 aroM protein - Emericella nidulans
Length = 1603
Score = 150 bits (374), Expect = 3e-35
Identities = 96/252 (38%), Positives = 139/252 (55%), Gaps = 24/252 (9%)
Query: 60 PDGEEYKTIETAIKIWDELVSFG--FTRKSLLIGLGGGVITDIAGFVASTYMRGTLLGFI 117
P GE K+ +T I D ++S R +++I LGGGVI D+ GFVASTYMRG +
Sbjct: 78 PPGEVSKSRQTKADIEDWMLSQNPPCGRDTVVIALGGGVIGDLTGFVASTYMRGVRYVQV 137
Query: 118 PTTLLAQVDAAIGGKTGVNFH-GKNMIGTFYLPNFVLISTETLSTLPRIELLNGMAEVIK 176
PTTLLA VD++IGGKT ++ GKN+IG + P + I E L TLP E +NGMAEVIK
Sbjct: 138 PTTLLAMVDSSIGGKTAIDTPLGKNLIGAIWQPTKIYIDLEFLETLPVREFINGMAEVIK 197
Query: 177 ---------YAILDKNVYRLLQDVK-----NVEEIRNREDIIR----ESVNVKVRVVEED 218
+ L++N +L+ V+ E+I++ S K VV D
Sbjct: 198 TAAISSEEEFTALEENAETILKAVRREVTPGEHRFEGTEEILKARILASARHKAYVVSAD 257
Query: 219 LKESGKRRILNLGHTVGHAIEKLSGYKIKHGFAVSVGLIAAAKLGEK---LYNFDSGKVI 275
+E G R +LN GH++GHAIE + +I HG V++G++ A+L L +++
Sbjct: 258 EREGGLRNLLNWGHSIGHAIEAILTPQILHGECVAIGMVKEAELARHLGILKGVAVSRIV 317
Query: 276 ELVERFNLPTKL 287
+ + + LPT L
Sbjct: 318 KCLAAYGLPTSL 329
>sp|P07547|ARO1_EMENI PENTAFUNCTIONAL AROM POLYPEPTIDE [INCLUDES: 3-DEHYDROQUINATE
SYNTHASE ; 3-DEHYDROQUINATE DEHYDRATASE
(3-DEHYDROQUINASE); SHIKIMATE 5-DEHYDROGENASE ;
SHIKIMATE KINASE ; 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSFERASE
(5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYN>
>gi|3834343|emb|CAA28836.1| (X05204) arom polypeptide
[Emericella nidulans]
Length = 1586
Score = 150 bits (374), Expect = 3e-35
Identities = 96/252 (38%), Positives = 139/252 (55%), Gaps = 24/252 (9%)
Query: 60 PDGEEYKTIETAIKIWDELVSFG--FTRKSLLIGLGGGVITDIAGFVASTYMRGTLLGFI 117
P GE K+ +T I D ++S R +++I LGGGVI D+ GFVASTYMRG +
Sbjct: 78 PPGEVSKSRQTKADIEDWMLSQNPPCGRDTVVIALGGGVIGDLTGFVASTYMRGVRYVQV 137
Query: 118 PTTLLAQVDAAIGGKTGVNFH-GKNMIGTFYLPNFVLISTETLSTLPRIELLNGMAEVIK 176
PTTLLA VD++IGGKT ++ GKN+IG + P + I E L TLP E +NGMAEVIK
Sbjct: 138 PTTLLAMVDSSIGGKTAIDTPLGKNLIGAIWQPTKIYIDLEFLETLPVREFINGMAEVIK 197
Query: 177 ---------YAILDKNVYRLLQDVK-----NVEEIRNREDIIR----ESVNVKVRVVEED 218
+ L++N +L+ V+ E+I++ S K VV D
Sbjct: 198 TAAISSEEEFTALEENAETILKAVRREVTPGEHRFEGTEEILKARILASARHKAYVVSAD 257
Query: 219 LKESGKRRILNLGHTVGHAIEKLSGYKIKHGFAVSVGLIAAAKLGEK---LYNFDSGKVI 275
+E G R +LN GH++GHAIE + +I HG V++G++ A+L L +++
Sbjct: 258 EREGGLRNLLNWGHSIGHAIEAILTPQILHGECVAIGMVKEAELARHLGILKGVAVSRIV 317
Query: 276 ELVERFNLPTKL 287
+ + + LPT L
Sbjct: 318 KCLAAYGLPTSL 329
>pdb|1DQS|B Chain B, Crystal Structure Of Dehydroquinate Synthase (Dhqs)
Complexed With Carbaphosphonate, Nad+ And Zn2+
>gi|5822048|pdb|1DQS|A Chain A, Crystal Structure Of
Dehydroquinate Synthase (Dhqs) Complexed With
Carbaphosphonate, Nad+ And Zn2+
Length = 393
Score = 150 bits (374), Expect = 3e-35
Identities = 96/252 (38%), Positives = 139/252 (55%), Gaps = 24/252 (9%)
Query: 60 PDGEEYKTIETAIKIWDELVSFG--FTRKSLLIGLGGGVITDIAGFVASTYMRGTLLGFI 117
P GE K+ +T I D ++S R +++I LGGGVI D+ GFVASTYMRG +
Sbjct: 78 PPGEVSKSRQTKADIEDWMLSQNPPCGRDTVVIALGGGVIGDLTGFVASTYMRGVRYVQV 137
Query: 118 PTTLLAQVDAAIGGKTGVNFH-GKNMIGTFYLPNFVLISTETLSTLPRIELLNGMAEVIK 176
PTTLLA VD++IGGKT ++ GKN+IG + P + I E L TLP E +NGMAEVIK
Sbjct: 138 PTTLLAMVDSSIGGKTAIDTPLGKNLIGAIWQPTKIYIDLEFLETLPVREFINGMAEVIK 197
Query: 177 ---------YAILDKNVYRLLQDVK-----NVEEIRNREDIIR----ESVNVKVRVVEED 218
+ L++N +L+ V+ E+I++ S K VV D
Sbjct: 198 TAAISSEEEFTALEENAETILKAVRREVTPGEHRFEGTEEILKARILASARHKAYVVSAD 257
Query: 219 LKESGKRRILNLGHTVGHAIEKLSGYKIKHGFAVSVGLIAAAKLGEK---LYNFDSGKVI 275
+E G R +LN GH++GHAIE + +I HG V++G++ A+L L +++
Sbjct: 258 EREGGLRNLLNWGHSIGHAIEAILTPQILHGECVAIGMVKEAELARHLGILKGVAVSRIV 317
Query: 276 ELVERFNLPTKL 287
+ + + LPT L
Sbjct: 318 KCLAAYGLPTSL 329
>dbj|BAA83344.1| (AB019237) 2-deoxy-scyllo-inosose synthase 41 KDa subunit [Bacillus
circulans] >gi|11191970|dbj|BAB18042.1| (AB033991) BtrC
[Bacillus circulans]
Length = 368
Score = 133 bits (332), Expect = 2e-30
Identities = 75/210 (35%), Positives = 114/210 (53%), Gaps = 5/210 (2%)
Query: 62 GEEYKTIETAIKIWDELVSFGFTRKSLLIGLGGGVITDIAGFVASTYMRGTLLGFIPTTL 121
GEEYKT+ T + + ++ G R++ ++ +GGG+ ++AG A RG L +PTT
Sbjct: 71 GEEYKTLSTVTNLQERAIALGANRRTAIVAVGGGLTGNVAGVAAGMMFRGIALIHVPTTF 130
Query: 122 LAQVDAAIGGKTGVNF-HGKNMIGTFYLPNFVLISTETLSTLPRIELLNGMAEVIK-YAI 179
LA D+ + K VN GKN++G +Y P FV T LS P ++ GM E++K I
Sbjct: 131 LAASDSVLSIKQAVNLTSGKNLVGFYYPPRFVFADTRILSESPPRQVKAGMCELVKNMLI 190
Query: 180 LDKNVYRLLQD---VKNVEEIRNREDIIRESVNVKVRVVEEDLKESGKRRILNLGHTVGH 236
L+ + +D NV + E I ++ K+ V+ ED+ E K I GHT+GH
Sbjct: 191 LENDNKEFTEDDLNSANVYSPKQLETFINFCISAKMSVLSEDIYEKKKGLIFEYGHTIGH 250
Query: 237 AIEKLSGYKIKHGFAVSVGLIAAAKLGEKL 266
AIE I HG A++VG+I AAK+ ++
Sbjct: 251 AIELAEQGGITHGEAIAVGMIYAAKIANRM 280
>emb|CAC02872.1| (AL390114) probable 3-dehydroquinate synthase [Leishmania major]
Length = 203
Score = 101 bits (250), Expect = 1e-20
Identities = 55/126 (43%), Positives = 79/126 (62%), Gaps = 4/126 (3%)
Query: 32 VLTNDMLKSLWLDKIIELLGG---DVFPIVIPDGEEYKTIETAIKIWDELVSFGFTRKSL 88
++TN+ + L+ ++ L G V + +PDGE +K +T I+D L+ G RK+
Sbjct: 67 IVTNETVGPLYAARVEATLAGLGKIVRTVTLPDGESFKHWQTLXLIFDALLGAGADRKTT 126
Query: 89 LIGLGGGVITDIAGFVASTYMRGTLLGFIPTTLLAQVDAAIGGKTGVNFH-GKNMIGTFY 147
LI LGGGV+ + GF A+ YMRG +PTTLLAQVD+++GGKTG+N GK MIG F+
Sbjct: 127 LIALGGGVVGXMTGFAAACYMRGVPFVQMPTTLLAQVDSSVGGKTGINHXLGKXMIGAFH 186
Query: 148 LPNFVL 153
P V+
Sbjct: 187 QPXAVI 192
>sp|Q9ZAE9|ACBC_ACTS5 2-EPI-VALIOLONE SYNTHASE >gi|4033329|emb|CAA77208.1| (Y18523)
2-epi-valiolone synthase [Actinoplanes sp. 50/110]
Length = 382
Score = 84.3 bits (205), Expect = 2e-15
Identities = 90/320 (28%), Positives = 143/320 (44%), Gaps = 34/320 (10%)
Query: 32 VLTNDMLKSLWLDKIIELL---GGDVFPIVIPDGEEYKTIETAIKIWDELVSFGFTRK-S 87
V+ + + +L+ +I E G D +V+ GE K +TA +I + +FG R+
Sbjct: 59 VVVDSAVDALYGSRIREYFTHHGIDHSILVMRVGETVKDFDTAGRIVAAMDAFGLARRRE 118
Query: 88 LLIGLGGGVITDIAGFVASTYMRGTLLGFIPTTLLAQVDAAIGGKTGVNFHG-KNMIGTF 146
+I +GGGV+ D+AG VAS Y + +PTTL+ +D A+ + VNF+G K G
Sbjct: 119 PMIVVGGGVLMDVAGLVASLYRARHAVLRVPTTLVGLID-AVSREDRVNFNGHKEPAGYV 177
Query: 147 YLPNFVLISTETLSTLPRIELLNGMAEVIKYAIL-DKNVYRLLQDVKNVEEIRNREDIIR 205
+ L+ L+TL R L NG+AE++K A++ D +++LL+ V I R +
Sbjct: 178 RPADLTLLDRRFLATLDRRHLSNGLAEMLKIALIKDAELFQLLERHGRV-LIEERFQGVP 236
Query: 206 ESVN-----------VKVRVVEEDLKESGKRRILNLGHTVGHAIEKLSGYKIKHGFAVSV 254
E V +L ES R ++ GHT IE + + HG AV V
Sbjct: 237 EPVTGPPSGPCARHPWHAGGTRPNLWESRLERSVDYGHTFSPTIEMRALPALLHGEAVCV 296
Query: 255 GLIAAAKLGEKLYNFD---SGKVIELVERFNLPTKLPYPPKDIIEAMKLD----KKAW-- 305
+ L + D ++ ++ LPT P +++EA D + W
Sbjct: 297 DMALTTVLAYRRGLLDVAQRDRIFAVMTALGLPTWHPLLTPEVLEAALQDTVRHRDGWQR 356
Query: 306 ------YGKIVFVIPVEIGR 319
G + FV V GR
Sbjct: 357 LPLPVGIGGVTFVNDVTAGR 376
>sp|P34002|AROB_PSEAE 3-DEHYDROQUINATE SYNTHASE >gi|309862|gb|AAC36825.1| (L13866)
dehydroquinate synthase [Pseudomonas aeruginosa]
Length = 104
Score = 80.0 bits (194), Expect = 4e-14
Identities = 41/72 (56%), Positives = 51/72 (69%), Gaps = 1/72 (1%)
Query: 110 RGTLLGFIPTTLLAQVDAAIGGKTGVNFH-GKNMIGTFYLPNFVLISTETLSTLPRIELL 168
RG +PTTLL+QVD+++GGKTG+N GKNMIG FY P V+I T +L TLP EL
Sbjct: 1 RGVNFIQVPTTLLSQVDSSVGGKTGINHPLGKNMIGAFYQPQAVVIDTASLKTLPSRELS 60
Query: 169 NGMAEVIKYAIL 180
G+AEVIKY +
Sbjct: 61 AGLAEVIKYGFI 72
>gb|AAD31832.1| (AF131879) aminodehydroquinate synthase [Streptomyces collinus]
Length = 248
Score = 79.6 bits (193), Expect = 5e-14
Identities = 54/157 (34%), Positives = 77/157 (48%), Gaps = 11/157 (7%)
Query: 75 WDELVSFGFTRKSLLIGLGGGVITDIAGFVASTYMRGTLLGFIPTTLLAQVDAAIGGKTG 134
W S TR ++ +GGG TD+ G A+ + RG + +PTTLLAQV +GG+T
Sbjct: 79 WARSPSSTRTRAYGVVSVGGGTTTDVVGLAAALFHRGVPVVQLPTTLLAQVYTGVGGRTA 138
Query: 135 VN-FHGKNMIGTFYLPNFVLISTETLSTLPRIELLNGMAEVIKYAILDKNVYRLLQDVKN 193
VN GKN+IG P+ VL T+ TLP E+LNG E+ + + R L
Sbjct: 139 VNPPEGKNLIGAHGQPSAVLCDTDDRETLPGREMLNGHGEIARCDFIGAGDLRELTPPVQ 198
Query: 194 VEEIRNREDIIRESVNVKVRVVEEDLKESGKRRILNL 230
I SV K + V D +++G R + +L
Sbjct: 199 ----------IAASVARKAQTVSADERDTGLRDLPSL 225
>emb|CAC02871.1| (AL390114) probable 3-dehydroquinate synthase [Leishmania major]
Length = 160
Score = 77.3 bits (187), Expect = 2e-13
Identities = 60/156 (38%), Positives = 78/156 (49%), Gaps = 11/156 (7%)
Query: 158 TLSTLPRIELLNGMAEVIKY-AILDKNVYRLLQD---VKNVEEIRNREDIIRESVNVKVR 213
TL TLP EL G+AEVIK+ AI D + + ++ N + +R S +K
Sbjct: 6 TLKTLPPRELAAGLAEVIKHGAIADADYFGWIEQHIGALNACDADMLALAVRRSCEIKAA 65
Query: 214 VVEEDLKESGKRRILNLGHTVGHAIEKLSGY-KIKHGFAVSVGLIAAAKLGEKLYNFDSG 272
VV D +E G R LN GHT GHAIE GY + HG AV G++ AA L +L F
Sbjct: 66 VVAADEREGGIRATLNFGHTFGHAIEAGMGYGEWLHGEAVGCGMVMAADLSLRL-GFIDI 124
Query: 273 KVIELVERFNLPTKLPYPPKDI-----IEAMKLDKK 303
+ +ER LP D+ IE MK+DKK
Sbjct: 125 ETRSRIERLVAAAMLPVVAPDLGVDRYIELMKVDKK 160
Database: ./suso.pep
Posted date: Jul 6, 2001 5:57 PM
Number of letters in database: 840,471
Number of sequences in database: 2977
Database: /banques/blast2/nr.pep
Posted date: Dec 14, 2000 12:46 PM
Number of letters in database: 188,266,275
Number of sequences in database: 595,510
Lambda K H
0.320 0.142 0.402
Gapped
Lambda K H
0.270 0.0470 0.230
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 125322323
Number of Sequences: 2977
Number of extensions: 5412984
Number of successful extensions: 14721
Number of sequences better than 1.0e-10: 51
Number of HSP's better than 0.0 without gapping: 41
Number of HSP's successfully gapped in prelim test: 10
Number of HSP's that attempted gapping in prelim test: 14548
Number of HSP's gapped (non-prelim): 53
length of query: 338
length of database: 189,106,746
effective HSP length: 56
effective length of query: 282
effective length of database: 155,591,474
effective search space: 43876795668
effective search space used: 43876795668
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 41 (21.8 bits)
S2: 165 (68.7 bits)