BLASTP 2.0.10 [Aug-26-1999]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= PAB0301 (thrB-2) DE:HOMOSERINE KINASE
         (274 letters)

Database: ./suso.pep; /banques/blast2/nr.pep
           598,487 sequences; 189,106,746 total letters

Searching..................................................done

                                                                   Score     E
Sequences producing significant alignments:                        (bits)  Value

pir||F75161 homoserine kinase PAB0301 - Pyrococcus abyssi (strai...   536  e-151
pir||E69207 conserved hypothetical protein MTH805 - Methanobacte...   161  1e-38
pir||G64479 hypothetical protein MJ1440 - Methanococcus jannasch...   152  3e-36
gb|AAG19605.1| (AE005050) Vng1245c [Halobacterium sp. NRC-1]          150  2e-35
pir||D72642 hypothetical protein APE0572 - Aeropyrum pernix (str...   114  1e-24
emb|CAC11428.1| (AL445063) conserved hypothetical protein [Therm...   112  4e-24
gi|11498131 conserved hypothetical protein [Archaeoglobus fulgid...   111  9e-24
gb|AAK40645.1| Conserved hypothetical protein [Sulfolobus solfat...   111  1e-23

>pir||F75161 homoserine kinase PAB0301 - Pyrococcus abyssi (strain Orsay)
           >gi|5457883|emb|CAB49373.1| (AJ248284) HOMOSERINE KINASE
           [Pyrococcus abyssi]
           Length = 274
           
 Score =  536 bits (1366), Expect = e-151
 Identities = 274/274 (100%), Positives = 274/274 (100%)

Query: 1   MRGSGRASSAITIVNAFATGKGAAIGIELWTEARVRVTGDGEVRGKIVVKGEEFKDYRLV 60
           MRGSGRASSAITIVNAFATGKGAAIGIELWTEARVRVTGDGEVRGKIVVKGEEFKDYRLV
Sbjct: 1   MRGSGRASSAITIVNAFATGKGAAIGIELWTEARVRVTGDGEVRGKIVVKGEEFKDYRLV 60

Query: 61  NSVISVLREVTGEPFGVRFEIHSDIPVGKGLKSSSAAANSLTKALVEALRLNIDDLSIVK 120
           NSVISVLREVTGEPFGVRFEIHSDIPVGKGLKSSSAAANSLTKALVEALRLNIDDLSIVK
Sbjct: 61  NSVISVLREVTGEPFGVRFEIHSDIPVGKGLKSSSAAANSLTKALVEALRLNIDDLSIVK 120

Query: 121 LGVEAAKRAGVTITGAFDDACASYFGGLCITDNYEMEILVKREINPETVVLLIPRETVLT 180
           LGVEAAKRAGVTITGAFDDACASYFGGLCITDNYEMEILVKREINPETVVLLIPRETVLT
Sbjct: 121 LGVEAAKRAGVTITGAFDDACASYFGGLCITDNYEMEILVKREINPETVVLLIPRETVLT 180

Query: 181 ESLKGVDFSKISPFIGEALRLAISGEWKKALVINGLLYSTFLGYDLAPMREALKLGAFVG 240
           ESLKGVDFSKISPFIGEALRLAISGEWKKALVINGLLYSTFLGYDLAPMREALKLGAFVG
Sbjct: 181 ESLKGVDFSKISPFIGEALRLAISGEWKKALVINGLLYSTFLGYDLAPMREALKLGAFVG 240

Query: 241 LCGKGPAFFAIADEPEEIIEAWSSFGDVIATSLR 274
           LCGKGPAFFAIADEPEEIIEAWSSFGDVIATSLR
Sbjct: 241 LCGKGPAFFAIADEPEEIIEAWSSFGDVIATSLR 274


>pir||E69207 conserved hypothetical protein MTH805 - Methanobacterium
           thermoautotrophicum (strain Delta H)
           >gi|2621895|gb|AAB85305.1| (AE000858) conserved protein
           (homoserine kinase related) [Methanobacterium
           thermoautotrophicum]
           Length = 289
           
 Score =  161 bits (402), Expect = 1e-38
 Identities = 98/277 (35%), Positives = 151/277 (54%), Gaps = 14/277 (5%)

Query: 6   RASSAITIVNAFATGKGAAIGIELWTEARVRVTGDGEVRGKIVVKGEEFKDYRLVNSVIS 65
           R+  + T++NA ATG+G+A GI L  EA   +   G     +     E  D  L+     
Sbjct: 9   RSPGSATVINAIATGRGSAFGIGLRVEAEAELIDSG-----VECISREGADTSLMELCTR 63

Query: 66  VLREVTGEPFGVRFEIHSDIPVGKGLKSSSAAANSLTKALVEALRLN-----IDDLSIVK 120
           ++ E  G   GVR    SD+PV  GL SSSAA+N+   A+   L        ++D  ++ 
Sbjct: 64  MVIEHYGVDAGVRVVTSSDLPVASGLSSSSAASNATVMAVSSLLSDEFGLQPMEDFEMLN 123

Query: 121 LGVEAAKRAGVTITGAFDDACASYFGGLCITDNYEMEILVKREINPETVVLLIPRETVLT 180
           + V+A+ +AGV++TGA+DDA AS++GGL +TDN E  I+++  +  + V++ +P    LT
Sbjct: 124 MAVDASLQAGVSVTGAYDDASASFYGGLTVTDNMERRIILREPMENQKVLIYMPDRKSLT 183

Query: 181 ESLKGVDFSKISPFIGEALRLAISGEWKKALVINGLLYSTFLGYDLAPMREALKLGAF-V 239
                     ++P++  A R  + G    AL +NG+LY   LG+D     +AL+ GA   
Sbjct: 184 AQSDVPRMKLLAPWVDMAFREVLDGRVHSALTLNGILYCASLGFDPGIALDALEAGALAA 243

Query: 240 GLCGKGPAFFAIADEPEE--IIEAWSSF-GDVIATSL 273
           GL G GP+F A+  E  E  II+AW +  GDV+ TS+
Sbjct: 244 GLSGTGPSFVALTHEDSEADIIDAWENLEGDVLVTSV 280


>pir||G64479 hypothetical protein MJ1440 - Methanococcus jannaschii
           >gi|1500322|gb|AAB99451.1| (U67585) conserved
           hypothetical protein [Methanococcus jannaschii]
           Length = 282
           
 Score =  152 bits (381), Expect = 3e-36
 Identities = 101/280 (36%), Positives = 162/280 (57%), Gaps = 17/280 (6%)

Query: 1   MRGSGRASSAITIVNAFATGKGAAIGIELWTEARVRVTGDGE--VRGKIVVKGEEFKDYR 58
           M G   A ++ TI+NA ATGKG+A G++L   A+V++  DG+  + GK V+     K   
Sbjct: 1   MEGKAYALASGTIINAIATGKGSAFGLDLKVYAKVKLIDDGKNKIEGK-VLDNPNIKPNL 59

Query: 59  LVNSVISVLREVTGEPFGVRFEIHSDIPVGKGLKSSSAAANSLTKALVEALRLNIDDLSI 118
           +V  V + L +  G  +    E  ++IP+  GL SSSA +N++  A  +AL   IDD  I
Sbjct: 60  IVRCVKNTL-DYFGLNYSAYVETKTEIPIKSGLSSSSATSNAVVLATFDALGEKIDDELI 118

Query: 119 VKLGVEAAKRAGVTITGAFDDACASYFGGLCITDNYEMEILVKREINPE-TVVLLIPRET 177
           + LG++++    +T+TGA+DDA ASY+GG+ ITDN E +IL + ++  +  V++LIP   
Sbjct: 119 LNLGIKSSFDEKLTVTGAYDDATASYYGGITITDNIERKILKRDKMRDDLNVLILIPNLE 178

Query: 178 VLTESLKGVDFSK---ISPFIGEALRLAISGEWKKALVINGLLYSTFLGYDLAPMREALK 234
                 K VD ++   I  ++  A   AI+G + KAL +NG+LY++ L +      +AL 
Sbjct: 179 ------KNVDVNRMKLIKDYVEIAFNEAINGNYFKALFLNGILYASALNFPTNIAIDALD 232

Query: 235 LGAF-VGLCGKGPAFFAIADEP--EEIIEAWSSFGDVIAT 271
            GA   GL G GP++ A+ ++   E++ E  + +G VI T
Sbjct: 233 AGAITAGLSGTGPSYIAMVEDENVEKVKEKLNRYGKVILT 272


>gb|AAG19605.1| (AE005050) Vng1245c [Halobacterium sp. NRC-1]
           Length = 284
           
 Score =  150 bits (374), Expect = 2e-35
 Identities = 98/267 (36%), Positives = 143/267 (52%), Gaps = 8/267 (2%)

Query: 1   MRGSGRASSAITIVNAFATGKGAAIGIELWTEARVRVT-GDGEVRGKIVVKGEEFKDYRL 59
           M G   A +A T++NA ATG GAA  +++ TEA V VT  +  V G+I   G    D  L
Sbjct: 1   MDGRAVAPAAGTVLNALATGVGAAFALDIDTEASVSVTPSESGVSGEIA--GHPEADTAL 58

Query: 60  VNSVISVLREVTGEPFGVRFEIHSDIPVGKGLKSSSAAANSLTKALVEALRL--NIDDLS 117
           V   +S + +  G+  G      S++P+  GLKSSSAAAN+   A ++AL +   +D + 
Sbjct: 59  VERCVSRVIDRYGDGQGGHVRTESEVPLAAGLKSSSAAANATVLATLDALGVADEVDRVD 118

Query: 118 IVKLGVEAAKRAGVTITGAFDDACASYFGGLCITDNYEMEILVKREINPETVVLLIPRET 177
             +LGV+AA+ AGVT+TGAFDDA AS  GG+ +TDN E ++L +  +     V   P E 
Sbjct: 119 AARLGVQAARDAGVTVTGAFDDAAASMLGGVAMTDNREDDLLFRDAVEWHAAV-WTPPER 177

Query: 178 VLTESLKGVDFSKISPFIGEALRLAISGEWKKALVINGLLYSTFLGYDLAPMREALKLGA 237
             +         ++S        LA +G++  A+ +NGL +   L +  AP   AL   A
Sbjct: 178 AYSADADVARCERVSGLAEHVAALAAAGDYGTAMTVNGLAFCAALDFPTAPAVTALPHAA 237

Query: 238 FVGLCGKGPAFFAIADEP--EEIIEAW 262
            V L G GP++ A+ DE   EE+   W
Sbjct: 238 GVSLSGTGPSYVAVGDEDGIEEVSTRW 264


>pir||D72642 hypothetical protein APE0572 - Aeropyrum pernix (strain K1)
           >gi|5104225|dbj|BAA79540.1| (AP000060) 280aa long
           hypothetical protein [Aeropyrum pernix]
           Length = 280
           
 Score =  114 bits (282), Expect = 1e-24
 Identities = 84/269 (31%), Positives = 126/269 (46%), Gaps = 13/269 (4%)

Query: 6   RASSAITIVNAFATGK-GAAIGIELWTEARVRVTGDGEVRG-----KIVVKGEEFKDYRL 59
           RAS  +TIVNA   G+ G A G+ LW E+RVR     E RG      +  +GE     R+
Sbjct: 5   RASGGLTIVNAIGHGRLGGAAGLGLWVESRVR-----EARGLWAGVSLTPRGERRLPPRV 59

Query: 60  VNSVISVLREVTGEPFGVRFEIHSDIPVGKGLKSSSAAANSLTKALVEALRLNIDDLSIV 119
           + +  +    +     G+  E+H+  P G GLK S+A   SL +A++    +        
Sbjct: 60  LEAAATAACSLGACVEGLEAEVHTGFPPGVGLKGSAALLASLVEAVLRLKGVRAPPWRAA 119

Query: 120 KLGVEAAKRAGVTITGAFDDACASYFGGLCITDNYEMEI--LVKREINPETVVLLIPRET 177
                 ++ AG+++TGA DD  AS      ITDN  M I  L+ R+    T V+ +P   
Sbjct: 120 LAAARVSRGAGLSVTGALDDHAASLLEAPVITDNRGMAILRLLPRDGCRLTAVIGVPGVE 179

Query: 178 VLTESLKGVDFSKISPFIGEALRLAISGEWKKALVINGLLYSTFLGYDLAPMREALKLGA 237
              E+L    F + S     A RL ++GEW  A+ ++G+  +  LG +    R      A
Sbjct: 180 NPVENLDPSPFRRHSRLYDAAARLGLAGEWLPAMAVSGVAGALALGVEGLASRLYEAGAA 239

Query: 238 FVGLCGKGPAFFAIADEPEEIIEAWSSFG 266
             G+ GKGPA FA+ + P    E   + G
Sbjct: 240 AAGVTGKGPAVFALTERPRGAAEVLETAG 268


>emb|CAC11428.1| (AL445063) conserved hypothetical protein [Thermoplasma
           acidophilum]
           Length = 268
           
 Score =  112 bits (278), Expect = 4e-24
 Identities = 84/269 (31%), Positives = 126/269 (46%), Gaps = 20/269 (7%)

Query: 6   RASSAITIVNAFATGKGAAIGIELWTEARVRVTGDGEVRGKIVVKGEEFKDYRLVNSVIS 65
           R    ++I++AF  G G A  I++     VR        G    + +  +D R   S+ +
Sbjct: 7   RTHGGVSIISAFIDGMGGAFSIDVPMTVTVR-------EGTCSEEKKISEDIRRYLSIAT 59

Query: 66  VLREVTGEPFGVRFEIHSDIPVGKGLKSSSAAANSLTKALVEALRLNIDDLSIVKLGVEA 125
             R          F + S IP G GLKSSSA   +L KA+     ++I D+ I+    + 
Sbjct: 60  CFR----------FTVDSRIPSGYGLKSSSAYILALAKAMAVYSGIDISDMEIMTASADI 109

Query: 126 AKRAGVTITGAFDDACASYFGGLCITDNYEMEILVKREINPETVVLLIPRETVLTESLKG 185
           +K +G+++TGA DD C + +GG C+TDN +M+IL +R   PE  VL+       +     
Sbjct: 110 SKNSGLSMTGALDDLCQAMYGGYCLTDNRKMKIL-RRGRLPEMPVLVCADGDKRSSGKVS 168

Query: 186 VDFSKISPFIGEALRLAISGEWKKALVINGLLYSTFLGYDLAPMREALKLGA-FVGLCGK 244
           ++    +  I     LA  G    A V NGL+Y +  G DL  +   LK GA +    GK
Sbjct: 169 IE-GHFTNAIRRVEDLAFKGRIFDAAVANGLIYGSIFGMDLRLIGSMLKAGALYSSQSGK 227

Query: 245 GPAFFAIADEPEEIIEAWSSFGDVIATSL 273
           GPA F I  +    + A S  G  I T +
Sbjct: 228 GPAIFGIFADRRSAMNARSDIGFGIVTKI 256


>gi|11498131 conserved hypothetical protein [Archaeoglobus fulgidus]
           >gi|7447992|pir||H69314 conserved hypothetical protein
           AF0520 - Archaeoglobus fulgidus
           >gi|2650100|gb|AAB90713.1| (AE001068) conserved
           hypothetical protein [Archaeoglobus fulgidus]
           Length = 280
           
 Score =  111 bits (275), Expect = 9e-24
 Identities = 86/271 (31%), Positives = 137/271 (49%), Gaps = 28/271 (10%)

Query: 6   RASSAITIVNAFATGKGAAIGIELWTEARVRVTGDGEVRGKIVVKGEEFKDY---RLVNS 62
           +A +A T++NA  TG G+A GIE+ T  ++R + +     K+ V G E +     R++NS
Sbjct: 5   KAYAAGTVLNALPTGIGSAFGIEMHTIVKLRPSDEL----KVFVNGVERRSIVAERILNS 60

Query: 63  VISVLREVTGEPFGVRFEIHSDIPVGKGLKSSSAAANSLTKALVEALRLNIDDLSIVKLG 122
           +     +VT E       + S+IP G GL SSSA  N+L  A+ +     ++   I++  
Sbjct: 61  M-----DVTAEVI-----VESEIPGGSGLGSSSAFVNALICAVKKMKGEELNAFEILRSN 110

Query: 123 VEAAKRAGVTITGAFDDACASYFGGLCITDNYEMEILVKREINPETVVLLIPRETVLTES 182
              +  AG++ TGAFDDA AS  GG  ++DN +M ++   E    + V LIP+      S
Sbjct: 111 ARFSLEAGISYTGAFDDASASMLGGFVVSDNRKMRLIRTDEFEGYSAV-LIPK-----FS 164

Query: 183 LKGVDFSKISPFIGE---ALRLAISGEWKKALVINGLLYSTFLGYDLAPMREALKLGAFV 239
              VD+ ++     E   A+  A+ GE+ KA+ +N       LGY L    +  + G   
Sbjct: 165 RGKVDWRRLRERASEVEGAVEAAMRGEYCKAMKLNTEYICKMLGYPLEIAEKGWEKGICC 224

Query: 240 GLCGKGPAF--FAIADEPEEIIEAWSSFGDV 268
           G+ G GP++  F   +E E + E W  +G V
Sbjct: 225 GISGNGPSYVAFGSKNEMEALAETWGEYGRV 255


>gb|AAK40645.1| Conserved hypothetical protein [Sulfolobus solfataricus]
           Length = 275
           
 Score =  111 bits (274), Expect = 1e-23
 Identities = 84/267 (31%), Positives = 141/267 (52%), Gaps = 19/267 (7%)

Query: 6   RASSAITIVNAFATGKGAAIGIELWTEARVRVTGDGEVRGKIVVKGEEFKDYRLVNSVIS 65
           +A   ++IVNA  +  G+++ I L  +  +R        GK V   E      L+ ++++
Sbjct: 9   QAYGGVSIVNALPSWYGSSMAINLKVKVEIR-------EGKRVYSQES----ELIKTILN 57

Query: 66  VLREVTGEPFGVRFEIHSDIPVGKGLKSSSAAANSLTKALVEALRLNIDDLSIVKLGVEA 125
             +E    P  +  +I S++P   GLKSSSA + +L   +  A + ++ +++   L    
Sbjct: 58  YFKEKYSIP-DIEVDIESELPQKSGLKSSSAVSVALIAEI--AKQYDLRNINPPILSAIL 114

Query: 126 AKRAGVTITGAFDDACASYFGGLCITDNYEMEILVKREINPETVVLLIPRETVLTESLKG 185
           + +AGV+ TGA DDA ASY GG+  T N +M  +VK E   + + +LI  +    + +  
Sbjct: 115 SLKAGVSYTGALDDAVASYCGGIAFTYN-KMFRIVKLENLEDNLSILILAKGGRQKPVNL 173

Query: 186 VDFSKISPFIGEALRLAISGEWKKALVINGLLYSTFLGYDLAPMREALKLGAF-VGLCGK 244
            +  K S    E  ++A+  ++  A+ +NG+L +  LGY L P+  ALK GA   G+ G 
Sbjct: 174 NELRKYSHVFEEIFKIALK-DYLTAMKMNGILIANILGYSLEPIEIALKKGALAAGISGN 232

Query: 245 GPAFFAIADEPEE--IIEAWSSFGDVI 269
           GP++FA++   EE  I E+   FGDVI
Sbjct: 233 GPSYFAVSKNGEEGPIYESLKKFGDVI 259


  Database: ./suso.pep
    Posted date:  Jul 6, 2001  5:57 PM
  Number of letters in database: 840,471
  Number of sequences in database:  2977
  
  Database: /banques/blast2/nr.pep
    Posted date:  Dec 14, 2000 12:46 PM
  Number of letters in database: 188,266,275
  Number of sequences in database:  595,510
  
Lambda     K      H
   0.319    0.138    0.390 

Gapped
Lambda     K      H
   0.270   0.0470    0.230 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 95430102
Number of Sequences: 2977
Number of extensions: 3818264
Number of successful extensions: 8405
Number of sequences better than 1.0e-10: 8
Number of HSP's better than  0.0 without gapping: 4
Number of HSP's successfully gapped in prelim test: 4
Number of HSP's that attempted gapping in prelim test: 8382
Number of HSP's gapped (non-prelim): 8
length of query: 274
length of database: 189,106,746
effective HSP length: 57
effective length of query: 217
effective length of database: 154,992,987
effective search space: 33633478179
effective search space used: 33633478179
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 41 (21.7 bits)
S2: 164 (68.3 bits)