BLASTP 2.0.10 [Aug-26-1999]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= PAB0319 (tmk-like) DE:thymidylate kinase related (tmk)
         (205 letters)

Database: ./suso.pep; /banques/blast2/nr.pep
           598,487 sequences; 189,106,746 total letters

Searching..................................................done

                                                                   Score     E
Sequences producing significant alignments:                        (bits)  Value

pir||A75165 thymidylate kinase related (tmk) PAB0319 - Pyrococcu...   406  e-112
sp|O59366|KTHY_PYRHO PROBABLE THYMIDYLATE KINASE (DTMP KINASE) >...   350  6e-96
sp|Q57741|KTHY_METJA PROBABLE THYMIDYLATE KINASE (DTMP KINASE) >...   133  2e-30
sp|O67099|KTHY_AQUAE THYMIDYLATE KINASE (DTMP KINASE) >gi|743464...   132  3e-30
gi|11497681 thymidylate kinase (tmk) [Archaeoglobus fulgidus] >g...   131  5e-30
pir||T36663 protein kinase, transmembrane - Streptomyces coelico...   129  3e-29
pir||F82788 thymidylate kinase XF0580 [imported] - Xylella fasti...   121  7e-27
gb|AAK41077.1| Thymidylate kinase (tmK-1) [Sulfolobus solfataricus]   119  2e-26
sp|Q9UXG7|KTHY_SULSO PROBABLE THYMIDYLATE KINASE (DTMP KINASE) >...   119  2e-26
dbj|BAB03761.1| (AP001507) thymidylate kinase [Bacillus halodurans]   118  6e-26
pir||H71333 probable thymidylate kinase (tmk) - syphilis spiroch...   117  1e-25
sp|Q9X0I3|KTHY_THEMA THYMIDYLATE KINASE (DTMP KINASE) >gi|743464...   115  5e-25
pir||D75560 thymidylate kinase - Deinococcus radiodurans (strain...   115  5e-25
pir||E83275 thymidylate kinase PA2962 [imported] - Pseudomonas a...   113  1e-24
pir||G81700 thymidylate kinase TC0460 [imported] - Chlamydia mur...   110  1e-23
sp|P37537|KTHY_BACSU THYMIDYLATE KINASE (DTMP KINASE) >gi|212702...   109  2e-23
sp|O26009|KTHY_HELPY THYMIDYLATE KINASE (DTMP KINASE) >gi|743464...   109  2e-23
sp|O27793|KTHY_METTH PROBABLE THYMIDYLATE KINASE (DTMP KINASE) >...   108  4e-23
sp|P37345|KTHY_ECOLI THYMIDYLATE KINASE (DTMP KINASE) >gi|214553...   107  9e-23
sp|Q9RQJ9|KTHY_CAUCR THYMIDYLATE KINASE (DTMP KINASE) >gi|631831...   106  2e-22
pdb|4TMK|A Chain A, Complex Of E. Coli Thymidylate Kinase With T...   106  2e-22
gb|AAA93511.1| (L37441) thymidine:thymidylate kinase:zeocin resi...   105  4e-22
gb|AAA93513.1| (L37442) thymidylate:zeocin resistance protein:ND...   105  4e-22
pir||H81932 probable dTMP kinase (EC 2.7.4.9) NMA0869 [imported]...   105  4e-22
pir||B81173 thymidylate kinase NMB0670 [imported] - Neisseria me...   104  8e-22
sp|Q9ZJE5|KTHY_HELPJ THYMIDYLATE KINASE (DTMP KINASE) >gi|743464...   104  1e-21
sp|O69169|KTHY_YERPE THYMIDYLATE KINASE (DTMP KINASE) >gi|317688...   102  2e-21
pir||S76121 hypothetical protein - Synechocystis sp. (strain PCC...   101  5e-21
sp|Q55593|KTHY_SYNY3 THYMIDYLATE KINASE (DTMP KINASE)                 101  5e-21
sp|P47252|KTHY_MYCGE THYMIDYLATE KINASE (DTMP KINASE) >gi|136186...   101  9e-21
sp|O84191|KTHY_CHLTR THYMIDYLATE KINASE (DTMP KINASE) >gi|743465...    99  5e-20
pir||T41553 thymidylate kinase - fission yeast (Schizosaccharomy...    98  6e-20
sp|Q9Z8R5|KTHY_CHLPN THYMIDYLATE KINASE (DTMP KINASE) >gi|743465...    98  8e-20
pir||A64153 dTMP kinase (EC 2.7.4.9) - Haemophilus influenzae (s...    96  2e-19
sp|P44719|KTHY_HAEIN THYMIDYLATE KINASE (DTMP KINASE) >gi|157343...    96  2e-19
sp|Q9YA48|KTHY_AERPE PROBABLE THYMIDYLATE KINASE (DTMP KINASE) >...    96  2e-19
pir||A82128 thymidylate kinase VC2016 [imported] - Vibrio choler...    95  5e-19
sp|Q9ZCN9|KTHY_RICPR THYMIDYLATE KINASE (DTMP KINASE) >gi|743465...    95  7e-19
gb|AAK41441.1| Thymidylate kinase  (tmK-2) [Sulfolobus solfatari...    91  1e-17
pir||H82944 thymidylate kinase UU020 [imported] - Ureaplasma ure...    90  2e-17
sp|P75106|KTHY_MYCPN THYMIDYLATE KINASE (DTMP KINASE) >gi|214666...    87  2e-16
gb|AAA21719.1| (L16991) thymidylate kinase [Homo sapiens]              86  3e-16
gi|6912340 deoxythymidylate kinase (thymidylate kinase) [Homo sa...    83  2e-15
sp|P23919|KTHY_HUMAN THYMIDYLATE KINASE (DTMP KINASE)                  83  2e-15
gb|AAG20116.1| (AE005090) thymidylate kinase; Tmk [Halobacterium...    83  2e-15
sp|P57434|KTHY_BUCAI THYMIDYLATE KINASE (DTMP KINASE) >gi|100390...    82  5e-15
gi|6322517 thymidylate kinase; Cdc8p [Saccharomyces cerevisiae] ...    80  3e-14
gb|AAA35158.1| (K02116) thymidylate kinase [Saccharomyces cerevi...    80  3e-14
gb|AAA34486.1| (K01783) CDC8 gene [Saccharomyces cerevisiae]           78  6e-14
emb|CAB58191.1| (AJ270426) thymidylate kinase [Yersinia enteroco...    78  6e-14
emb|CAB58204.1| (AJ270417) thymidylate kinase [Yersinia pestis]        77  1e-13
emb|CAB58225.1| (AJ270418) thymidylate kinase [Yersinia pseudotu...    77  1e-13
emb|CAB58213.1| (AJ270422) thymidylate kinase [Yersinia pseudotu...    77  1e-13
emb|CAB58188.1| (AJ270423) thymidylate kinase [Yersinia enteroco...    77  1e-13
emb|CAB58192.1| (AJ270427) thymidylate kinase [Yersinia enteroco...    77  2e-13
pir||F81347 probable dTMP kinase (EC 2.7.4.9) Cj0766c [imported]...    76  2e-13
sp|Q22018|KTHY_CAEEL PROBABLE THYMIDYLATE KINASE (DTMP KINASE) >...    76  3e-13
emb|CAC11229.1| (AL445063) conserved hypothetical protein [Therm...    74  1e-12
sp|P36590|KTHY_SCHPO THYMIDYLATE KINASE (DTMP KINASE) >gi|478751...    73  2e-12
sp|P97930|KTHY_MOUSE THYMIDYLATE KINASE (DTMP KINASE) >gi|183604...    71  1e-11
pir||S48605 hypothetical protein - Mycoplasma capricolum (fragme...    69  4e-11
pir||H70198 thymidylate kinase (tmk) homolog - Lyme disease spir...    68  8e-11

>pir||A75165 thymidylate kinase related (tmk) PAB0319 - Pyrococcus abyssi
           (strain Orsay) >gi|5457910|emb|CAB49400.1| (AJ248284)
           thymidylate kinase related (tmk) [Pyrococcus abyssi]
           Length = 205
           
 Score =  406 bits (1032), Expect = e-112
 Identities = 205/205 (100%), Positives = 205/205 (100%)

Query: 1   MRGYFVVLEGIDGSGKTTQAKLLAEWFEEQGWDVLLTKEPTDTEFGRLIRELVLKNSIID 60
           MRGYFVVLEGIDGSGKTTQAKLLAEWFEEQGWDVLLTKEPTDTEFGRLIRELVLKNSIID
Sbjct: 1   MRGYFVVLEGIDGSGKTTQAKLLAEWFEEQGWDVLLTKEPTDTEFGRLIRELVLKNSIID 60

Query: 61  GSRISYEAEALLFAADRAEHVKKVILPALEKGKVVICDRYLYSSLAYQWARGLSLEWLMQ 120
           GSRISYEAEALLFAADRAEHVKKVILPALEKGKVVICDRYLYSSLAYQWARGLSLEWLMQ
Sbjct: 61  GSRISYEAEALLFAADRAEHVKKVILPALEKGKVVICDRYLYSSLAYQWARGLSLEWLMQ 120

Query: 121 INSFAPRPDLAILLDLPVKESIRRTKARGNMSEFDKLLELQRKVRMNYLKLAEMFKEMRI 180
           INSFAPRPDLAILLDLPVKESIRRTKARGNMSEFDKLLELQRKVRMNYLKLAEMFKEMRI
Sbjct: 121 INSFAPRPDLAILLDLPVKESIRRTKARGNMSEFDKLLELQRKVRMNYLKLAEMFKEMRI 180

Query: 181 VNAMASVEEVHEDIVALVKHELLGL 205
           VNAMASVEEVHEDIVALVKHELLGL
Sbjct: 181 VNAMASVEEVHEDIVALVKHELLGL 205


>sp|O59366|KTHY_PYRHO PROBABLE THYMIDYLATE KINASE (DTMP KINASE) >gi|7434646|pir||A71177
           probable thymidylate kinase - Pyrococcus horikoshii
           >gi|3258125|dbj|BAA30808.1| (AP000007) 205aa long
           hypothetical thymidylate kinase [Pyrococcus horikoshii]
           Length = 205
           
 Score =  350 bits (889), Expect = 6e-96
 Identities = 166/205 (80%), Positives = 192/205 (92%)

Query: 1   MRGYFVVLEGIDGSGKTTQAKLLAEWFEEQGWDVLLTKEPTDTEFGRLIRELVLKNSIID 60
           MRGYF+VLEGIDGSGKTTQAKLLAEWFE++G++VLLTKEPTD+E G+LIR ++L+ S+ID
Sbjct: 1   MRGYFIVLEGIDGSGKTTQAKLLAEWFEDKGYEVLLTKEPTDSELGKLIRRIILEESVID 60

Query: 61  GSRISYEAEALLFAADRAEHVKKVILPALEKGKVVICDRYLYSSLAYQWARGLSLEWLMQ 120
           GS+ISYEAEALLFAADRAEHVKK+ILPAL +GKVVICDRY YSSLAYQWARGL L WL+Q
Sbjct: 61  GSKISYEAEALLFAADRAEHVKKIILPALSEGKVVICDRYFYSSLAYQWARGLDLNWLIQ 120

Query: 121 INSFAPRPDLAILLDLPVKESIRRTKARGNMSEFDKLLELQRKVRMNYLKLAEMFKEMRI 180
           +NSFAPRPDLAILLDLPVKES+RR K RG ++EFDK++ELQRKVR NYLKLAEMF EMRI
Sbjct: 121 VNSFAPRPDLAILLDLPVKESLRRIKLRGTLTEFDKIVELQRKVRHNYLKLAEMFPEMRI 180

Query: 181 VNAMASVEEVHEDIVALVKHELLGL 205
           VNA++S+E++H DIVALVKHELLGL
Sbjct: 181 VNALSSIEDIHSDIVALVKHELLGL 205


>sp|Q57741|KTHY_METJA PROBABLE THYMIDYLATE KINASE (DTMP KINASE) >gi|2127876|pir||F64336
           dTMP kinase (EC 2.7.4.9) - Methanococcus jannaschii
           >gi|1591015|gb|AAB98278.1| (U67484) thymidylate kinase
           (tmk) [Methanococcus jannaschii]
           Length = 188
           
 Score =  133 bits (331), Expect = 2e-30
 Identities = 80/196 (40%), Positives = 121/196 (60%), Gaps = 16/196 (8%)

Query: 5   FVVLEGIDGSGKTTQAKLLAEWFEEQGWDVLLTKEPTDTEFGRLIRELVLKNSIIDGSRI 64
           F+V EGIDGSGKTTQ+KLLA+       D   T EP+++  G++IRE++   + +D   +
Sbjct: 6   FIVFEGIDGSGKTTQSKLLAKKM-----DAFWTYEPSNSLVGKIIREILSGKTEVDNKTL 60

Query: 65  SYEAEALLFAADRAEHVKKVILPALEKGKVVICDRYLYSSLAYQWARGLSLEWLMQINSF 124
                ALLFAADR EH K +I   L+K + V+CDRYLYSS+AYQ   G+   ++  IN +
Sbjct: 61  -----ALLFAADRIEHTK-LIKEELKK-RDVVCDRYLYSSIAYQSVAGVDENFIKSINRY 113

Query: 125 APRPDLAILLDLPVKESIRRTKARGNMSEFDKLLELQRKVRMNYLKLAEMFKEMRIVNAM 184
           A +PD+  LL + ++ +++R K +    + D L    +KV+  YL+LAE +  + I    
Sbjct: 114 ALKPDIVFLLIVDIETALKRVKTKDIFEKKDFL----KKVQDKYLELAEEYNFIVIDTTK 169

Query: 185 ASVEEVHEDIVALVKH 200
            SVEEVH +I+  +K+
Sbjct: 170 KSVEEVHNEIIGYLKN 185


>sp|O67099|KTHY_AQUAE THYMIDYLATE KINASE (DTMP KINASE) >gi|7434642|pir||H70383
           thymidylate kinase - Aquifex aeolicus
           >gi|2983484|gb|AAC07063.1| (AE000716) thymidylate kinase
           [Aquifex aeolicus]
           Length = 195
           
 Score =  132 bits (329), Expect = 3e-30
 Identities = 76/194 (39%), Positives = 126/194 (64%), Gaps = 14/194 (7%)

Query: 6   VVLEGIDGSGKTTQAKLLAEWFEEQGWDVLLTKEPTDTEFGRLIRELVLKNSIIDGSRIS 65
           +  EGIDGSGKTTQAK L E+ +++G+ V L +EP  T+ G ++RE++L   + +     
Sbjct: 3   IAFEGIDGSGKTTQAKKLYEYLKQKGYFVSLYREPGGTKVGEVLREILLTEELDE----- 57

Query: 66  YEAEALLFAADRAEHVKKVILPALEKGKVVICDRYLYSSLAYQ-WARGLSLEWLMQINSF 124
              E LLF A R++ +++ I+P L++ KVVI DR++ S++AYQ + +GL +E++  +N F
Sbjct: 58  -RTELLLFEASRSKLIEEKIIPDLKRDKVVILDRFVLSTIAYQGYGKGLDVEFIKNLNEF 116

Query: 125 APR---PDLAILLDLPVKESIRRTKARGNMSEFDKLLELQRKVRMNYLKLAEMFKEMRIV 181
           A R   PD+ +LLD+PV  ++RR K + N  E  + LE   KVR  +L+LA+  + + ++
Sbjct: 117 ATRGVKPDITLLLDIPVDIALRRLKEK-NRFENKEFLE---KVRKGFLELAKEEENVVVI 172

Query: 182 NAMASVEEVHEDIV 195
           +A    EEV ++I+
Sbjct: 173 DASGEEEEVFKEIL 186


>gi|11497681 thymidylate kinase (tmk) [Archaeoglobus fulgidus]
           >gi|6016458|sp|O30175|KTHY_ARCFU PROBABLE THYMIDYLATE
           KINASE (DTMP KINASE) >gi|7434641|pir||E69257 thymidylate
           kinase (tmk) homolog - Archaeoglobus fulgidus
           >gi|2650584|gb|AAB91163.1| (AE001102) thymidylate kinase
           (tmk) [Archaeoglobus fulgidus]
           Length = 196
           
 Score =  131 bits (327), Expect = 5e-30
 Identities = 76/195 (38%), Positives = 121/195 (61%), Gaps = 12/195 (6%)

Query: 6   VVLEGIDGSGKTTQAKLLAEWFEEQGWDVLLTKEPTDTEFGRLIRELVLKNSIIDGSRIS 65
           + +EGIDG+GKTT A  +AE  +E+G+ V + KEP D++FG+ I+            R+S
Sbjct: 3   IAVEGIDGAGKTTIAAYIAELLKEKGYKVKVLKEPGDSKFGKKIKS--------SEERLS 54

Query: 66  YEAEALLFAADRAEHVKKVILPALEKGKVVICDRYLYSSLAYQWARGLSLEWLMQIN-SF 124
            E E  LF  DR    ++ ILPAL+ G  V+ DRY +S++AYQ ARG+    + ++N   
Sbjct: 55  PEEELELFLKDREIDARENILPALQSGYAVVMDRYYFSNIAYQSARGIDARLIREMNEKI 114

Query: 125 APRPDLAILLDLPVKESIRRTKARGNMSEFDKLLELQRKVRMNYLKLAEMFKEMRIVNAM 184
           AP+PDL ILLD+  + ++ R + RG +S F+K L+  RKVR  +L+ A+  +   +V+A 
Sbjct: 115 APKPDLTILLDVEPEIALERVRKRGKLSPFEK-LDYLRKVRKCFLENAD--ETTVVVDAS 171

Query: 185 ASVEEVHEDIVALVK 199
             +EEV E++  +++
Sbjct: 172 KPLEEVKEEVRKVIE 186


>pir||T36663 protein kinase, transmembrane - Streptomyces coelicolor
           >gi|4539560|emb|CAB38479.1| (AL035636) integral membrane
           protein with kinase activity [Streptomyces coelicolor
           A3(2)]
           Length = 1089
           
 Score =  129 bits (321), Expect = 3e-29
 Identities = 83/205 (40%), Positives = 121/205 (58%), Gaps = 13/205 (6%)

Query: 3   GYFVVLEGIDGSGKTTQAKLLAEWFEEQGWDVLLTKEPTDTEFGRLIRELVLKNSIIDGS 62
           G+F+ LEG DG+GK+TQA+ LAEW   +G +V+LT+EP  T  G+ +R ++L    +  +
Sbjct: 509 GFFIALEGGDGAGKSTQAEALAEWIRGKGHEVVLTREPGATPVGKRLRSILLD---VSSA 565

Query: 63  RISYEAEALLFAADRAEHVKKVILPALEKGKVVICDRYLYSSLAYQWA-RGLSLEWLMQI 121
            +S+ AEALL+AADRAEHV  V+ PALE+G VV+ DRY+ SS+AYQ A R LS   + +I
Sbjct: 566 GLSHRAEALLYAADRAEHVDTVVRPALERGAVVVSDRYIDSSVAYQGAGRDLSPTEIARI 625

Query: 122 NSFAPR---PDLAILLDL-PVKESIRRTKARGNMSEFDKLLELQRKVRMNYLKLAEMFKE 177
           N +A     P L +LLD+ P     R T+A   +    +  E   +VR  +L LA     
Sbjct: 626 NRWATNGLVPHLTVLLDVAPEAARERFTEAPDRLE--SEPAEFHARVRSGFLTLAAADPG 683

Query: 178 MRIVNAMASVEEVHEDIVALVKHEL 202
             +V       +  E +  +V+H L
Sbjct: 684 RYLV---VDAGQEPEAVTTVVRHRL 705


>pir||F82788 thymidylate kinase XF0580 [imported] - Xylella fastidiosa  (strain
           9a5c) >gi|9105444|gb|AAF83390.1|AE003904_11 (AE003904)
           thymidylate kinase [Xylella fastidiosa]
           Length = 217
           
 Score =  121 bits (300), Expect = 7e-27
 Identities = 74/200 (37%), Positives = 112/200 (56%), Gaps = 8/200 (4%)

Query: 3   GYFVVLEGIDGSGKTTQAKLLAEWFEEQGWDVLLTKEPTDTEFGRLIRELVLKNSIIDGS 62
           G  V +EGIDG+GKTT A+ LA      G + +++KEPT+  +G L+R+           
Sbjct: 9   GMLVAIEGIDGAGKTTLARSLALKLRGVGLETVVSKEPTNGPWGMLLRQSAATG------ 62

Query: 63  RISYEAEALLFAADRAEHVKKVILPALEKGKVVICDRYLYSSLAYQWARGLSLEWLMQIN 122
           R S E E  +   DR +HV+ +I+P + +G VVI DRY  S +AYQ A GL ++ L++ N
Sbjct: 63  RFSPEEEVDVLLRDRRQHVEDLIVPMIGRGAVVILDRYFPSMVAYQGAAGLPVDALLEAN 122

Query: 123 SFAPRPDLAILLDLPVKESIRRTKARGNMSEFDKLLELQRKVRMNYLKLAEMFKEMRIVN 182
           +FAPRPD+ +LLD+P    ++R   RG+     +  E   + R  +L L       R+++
Sbjct: 123 AFAPRPDVLLLLDVPPAIGLQRIWERGSTPNHFETTENLSRCRDIFLALE--LPSKRVID 180

Query: 183 AMASVEEVHEDIVALVKHEL 202
           A A+ E V    +ALV   L
Sbjct: 181 ATANAETVLSAALALVMEVL 200


>gb|AAK41077.1| Thymidylate kinase (tmK-1) [Sulfolobus solfataricus]
           Length = 189
           
 Score =  119 bits (296), Expect = 2e-26
 Identities = 73/198 (36%), Positives = 115/198 (57%), Gaps = 15/198 (7%)

Query: 6   VVLEGIDGSGKTTQAKLLAEWFEEQ-GWDVLLTKEPTDTEFGRLIRELVLKNSIIDGSRI 64
           + +EGIDGSGKTT A LL E  E +   +V++T+EP   +  +LI ++   + I+     
Sbjct: 5   IAIEGIDGSGKTTLANLLKEHLESKMKLNVIVTREPFSEDIIKLIEKIGWNDPIL----- 59

Query: 65  SYEAEALLFAADRAEHVKKVILPALEKGKVVICDRYLYSSLAYQWARGLSLEWLMQINSF 124
                 LLFAADR  HV    L  ++   ++I DRY +SS+AYQ A G+  +W+  +NS+
Sbjct: 60  ----LVLLFAADREIHVNW--LSKIKDADLIILDRYYFSSIAYQGALGVDEQWIKMVNSY 113

Query: 125 APRPDLAILLDLPVKESIRRTKARGNMSEFDKLLELQRKVRMNYLKLAEMFKEMRIVNAM 184
            P+PD+ ILLDLP++ +I R K   +   F++ ++   KVR  YLKLA+ +    +V+A 
Sbjct: 114 FPKPDMVILLDLPIEVAISRIK--NDKFNFEEKIKSLAKVREKYLKLAKEY-NFYVVDAS 170

Query: 185 ASVEEVHEDIVALVKHEL 202
               EV E  + +++  L
Sbjct: 171 KDKNEVLEQAIKIIQKNL 188


>sp|Q9UXG7|KTHY_SULSO PROBABLE THYMIDYLATE KINASE (DTMP KINASE)
           >gi|6015696|emb|CAB57523.1| (Y18930) thymidylate kinase
           [Sulfolobus solfataricus]
           Length = 189
           
 Score =  119 bits (296), Expect = 2e-26
 Identities = 73/198 (36%), Positives = 115/198 (57%), Gaps = 15/198 (7%)

Query: 6   VVLEGIDGSGKTTQAKLLAEWFEEQ-GWDVLLTKEPTDTEFGRLIRELVLKNSIIDGSRI 64
           + +EGIDGSGKTT A LL E  E +   +V++T+EP   +  +LI ++   + I+     
Sbjct: 5   IAIEGIDGSGKTTLANLLKEHLESKMKLNVIVTREPFSEDIIKLIEKIGWNDPIL----- 59

Query: 65  SYEAEALLFAADRAEHVKKVILPALEKGKVVICDRYLYSSLAYQWARGLSLEWLMQINSF 124
                 LLFAADR  HV    L  ++   ++I DRY +SS+AYQ A G+  +W+  +NS+
Sbjct: 60  ----LVLLFAADREIHVNW--LSKIKDADLIILDRYYFSSIAYQGALGVDEQWIKMVNSY 113

Query: 125 APRPDLAILLDLPVKESIRRTKARGNMSEFDKLLELQRKVRMNYLKLAEMFKEMRIVNAM 184
            P+PD+ ILLDLP++ +I R K   +   F++ ++   KVR  YLKLA+ +    +V+A 
Sbjct: 114 FPKPDMVILLDLPIEVAISRIK--NDKFNFEEKIKSLAKVREKYLKLAKEY-NFYVVDAS 170

Query: 185 ASVEEVHEDIVALVKHEL 202
               EV E  + +++  L
Sbjct: 171 KDKNEVLEQAIKIIQKNL 188


>dbj|BAB03761.1| (AP001507) thymidylate kinase [Bacillus halodurans]
           Length = 210
           
 Score =  118 bits (292), Expect = 6e-26
 Identities = 76/209 (36%), Positives = 119/209 (56%), Gaps = 11/209 (5%)

Query: 2   RGYFVVLEGIDGSGKTTQAKLLAEWFEEQGWDVLLTKEPTDTEFGRLIRELVLKNSIIDG 61
           +G F+ +EG +G+GKT+    + E   E G  V+ T+EP        IR ++L    +D 
Sbjct: 3   KGCFITVEGGEGAGKTSALDAIEEMLRENGLSVVRTREPGGIPIAEQIRSIILD---VDH 59

Query: 62  SRISYEAEALLFAADRAEHVKKVILPALEKGKVVICDRYLYSSLAYQ-WARGLSLEWLMQ 120
           +R+    EALL+AA R +H+ + +LPALE G VV+CDR++ SSLAYQ +ARG+  E ++ 
Sbjct: 60  TRMDPRTEALLYAAARRQHLVEKVLPALEAGHVVLCDRFIDSSLAYQGYARGIGFEDILA 119

Query: 121 INSFAPR---PDLAIL--LDLPVKES-IRRTKARGNMSEFDKLLELQRKVRMNYLKLAEM 174
           IN FA     PDL +L  +D  V  S I R ++R       + L   +KV+  Y ++ E 
Sbjct: 120 INEFAIEGRYPDLTLLFRVDPDVGLSRIHRDQSREQNRLDQEALTFHQKVKEGYERIVET 179

Query: 175 FKEMRI-VNAMASVEEVHEDIVALVKHEL 202
           + E  + ++A  S ++V  D V ++K  L
Sbjct: 180 YPERVVEIDANQSFDQVVADAVRMIKQRL 208


>pir||H71333 probable thymidylate kinase (tmk) - syphilis spirochete
           >gi|3322633|gb|AAC65341.1| (AE001215) thymidylate kinase
           (tmk) [Treponema pallidum]
           Length = 208
           
 Score =  117 bits (290), Expect = 1e-25
 Identities = 73/199 (36%), Positives = 112/199 (55%), Gaps = 15/199 (7%)

Query: 5   FVVLEGIDGSGKTTQAKLLAEWFEEQGWDVLLTKEPTDTEFGRLIRELVLKNSIIDGSRI 64
           FVV EGIDG+G +TQ + L   F+ +  D++ T+EPT  E G LIR+++ K  I+     
Sbjct: 7   FVVFEGIDGTGTSTQLRALERHFQARK-DMVFTQEPTGGEIGTLIRDVLQKRVIM----- 60

Query: 65  SYEAEALLFAADRAEHVKKV--ILPALEKGKVVICDRYLYSSLAYQWARGLSLEWLMQIN 122
           S +A  LLFAADR EH++    I   L +GK+V+CDRY++SSL YQ    +S  +  ++N
Sbjct: 61  SSKALGLLFAADRHEHLEGAGGINDCLAEGKIVLCDRYVFSSLVYQ-GMAVSGSFAYELN 119

Query: 123 SFAPRPDLAILLDLPVKESIRRTKARGNMSEFDKLLELQRKVRMNY----LKLAEMFKEM 178
              P P++    D P++  + R  ARG  +E  +    Q K R  Y     K   ++  M
Sbjct: 120 KEFPLPEVVFYFDAPIEVCVERITARGLQTELYEYTSFQEKARKGYETIFRKCRHLYPAM 179

Query: 179 RI--VNAMASVEEVHEDIV 195
           ++  ++A   +E VHE I+
Sbjct: 180 KVIEIDAREEIEVVHERIL 198


>sp|Q9X0I3|KTHY_THEMA THYMIDYLATE KINASE (DTMP KINASE) >gi|7434647|pir||E72294
           thymidylate kinase - Thermotoga maritima (strain MSB8)
           >gi|4981644|gb|AAD36175.1|AE001769_5 (AE001769)
           thymidylate kinase [Thermotoga maritima]
           Length = 197
           
 Score =  115 bits (284), Expect = 5e-25
 Identities = 77/200 (38%), Positives = 117/200 (58%), Gaps = 16/200 (8%)

Query: 5   FVVLEGIDGSGKTTQAKLLAEWFEEQGWDVLLTKEPTDTEFGRLIRELVLKNSIIDGSRI 64
           F+  EGIDGSGK+TQ +LLA++ E++G  V+L +EP  TE G  IR+++L+        +
Sbjct: 2   FITFEGIDGSGKSTQIQLLAQYLEKRGKKVILKREPGGTETGEKIRKILLE------EEV 55

Query: 65  SYEAEALLFAADRAEHVKKVILPALEKGKVVICDRYLYSSLAYQ-WARGLSLEWLMQINS 123
           + +AE  LF A R   V + I   L +G  V+ DRY  SS+AYQ + R L  E + ++N 
Sbjct: 56  TPKAELFLFLASRNLLVTE-IKQYLSEGYAVLLDRYTDSSVAYQGFGRNLGKEIVEELND 114

Query: 124 FAPR---PDLAILLDLPVKESIRRTKARGNMSEFDKLLELQRKVRMNYLKLAEMFKEMRI 180
           FA     PDL   +D+ V+ +++R   +G ++ F+K  E   +VR  YL LA    E  +
Sbjct: 115 FATDGLIPDLTFYIDVDVETALKR---KGELNRFEK-REFLERVREGYLVLAREHPERIV 170

Query: 181 V-NAMASVEEVHEDIVALVK 199
           V +   S+EE+H D+V  VK
Sbjct: 171 VLDGKRSIEEIHRDVVREVK 190


>pir||D75560 thymidylate kinase - Deinococcus radiodurans (strain R1)
           >gi|6457772|gb|AAF09698.1|AE001873_8 (AE001873)
           thymidylate kinase [Deinococcus radiodurans]
           Length = 206
           
 Score =  115 bits (284), Expect = 5e-25
 Identities = 78/203 (38%), Positives = 112/203 (54%), Gaps = 10/203 (4%)

Query: 2   RGYFVVLEGIDGSGKTTQAKLLAEWFEEQGWDVLLTKEPTDTEFGRLIRELVLKNSIIDG 61
           +G F+ LEG +G+GKTTQ   L       G  V +T+EP  T  G  +RE+VL  ++   
Sbjct: 3   QGLFITLEGPEGAGKTTQLARLEARLRAAGHAVTVTREPGGTPLGTRVREVVLDPAV--- 59

Query: 62  SRISYEAEALLFAADRAEHVKKVILPALEKGKVVICDRYLYSSLAYQWA-RGLSLEWLMQ 120
             I    E LL++A RA+ V++V+ PALE+G+ V+CDRY  SSLAYQ A RGLSL  L Q
Sbjct: 60  -EIEPLGEFLLYSASRAQLVREVLRPALERGETVLCDRYADSSLAYQGAGRGLSLPLLRQ 118

Query: 121 INSFAP---RPDLAILLDLPVKESIRRTKARGNMSEFDKL-LELQRKVRMNYLKLAEMF- 175
           I +       P L +LLDL     ++R   RG     ++  L   R+VR  +L LA    
Sbjct: 119 ITAEVTGGLTPGLTVLLDLDPALGLQRAARRGQPDRLEQADLTFHRRVRQGFLDLAHAEP 178

Query: 176 KEMRIVNAMASVEEVHEDIVALV 198
           +   +++A    +E+  +I A V
Sbjct: 179 QRFLVLDATRPEDELEAEIWAAV 201


>pir||E83275 thymidylate kinase PA2962 [imported] - Pseudomonas aeruginosa
           (strain PAO1) >gi|9949060|gb|AAG06350.1|AE004722_6
           (AE004722) thymidylate kinase [Pseudomonas aeruginosa]
           Length = 210
           
 Score =  113 bits (281), Expect = 1e-24
 Identities = 78/208 (37%), Positives = 113/208 (53%), Gaps = 9/208 (4%)

Query: 1   MRGYFVVLEGIDGSGKTTQAKLLAEWFEEQGWDVLLTKEPTDTEFGRLIRELVLKNSIID 60
           M G FV LEG +G+GK+T    LAE   E+G +V LT+EP  T     IREL+L  S   
Sbjct: 1   MTGLFVTLEGPEGAGKSTNRDYLAERLRERGIEVQLTREPGGTPLAERIRELLLAPS--- 57

Query: 61  GSRISYEAEALLFAADRAEHVKKVILPALEKGKVVICDRYLYSSLAYQ-WARGLSLEWLM 119
              ++ + E LL  A RA+H+  VI PAL +G VV+CDR+  ++ AYQ   RGL    + 
Sbjct: 58  DEPMAADTELLLMFAARAQHLAGVIRPALARGAVVLCDRFTDATYAYQGGGRGLPEARIA 117

Query: 120 QINSFAP---RPDLAILLDLPVKESIRRTKARGNMSEFDKL-LELQRKVRMNYLKLAEMF 175
            + SF     RPDL ++ DLPV+  + R  ARG +  F++        VR  YL+ A   
Sbjct: 118 ALESFVQGDLRPDLTLVFDLPVEIGLARAAARGRLDRFEQEDRRFFEAVRQTYLQRAAQA 177

Query: 176 KE-MRIVNAMASVEEVHEDIVALVKHEL 202
            E  ++++A   + EV   +  L+ + L
Sbjct: 178 PERYQVLDAGLPLAEVQAGLDRLLPNLL 205


>pir||G81700 thymidylate kinase TC0460 [imported] - Chlamydia muridarum  (strain
           Nigg) >gi|7190503|gb|AAF39311.1| (AE002314) thymidylate
           kinase [Chlamydia muridarum]
           Length = 203
           
 Score =  110 bits (272), Expect = 1e-23
 Identities = 72/192 (37%), Positives = 109/192 (56%), Gaps = 12/192 (6%)

Query: 5   FVVLEGIDGSGKTTQAKLLAEWFEEQGWDVLLTKEPTDTEFGRLIRELVLKNSIIDGSRI 64
           F+V+EG +G+GKT   + L++   E+G +V+LT+EP  +  G  +R+LVL  +      I
Sbjct: 2   FIVVEGGEGAGKTQFTQALSKRLMEEGKEVVLTREPGGSALGEQLRDLVLDVT----QEI 57

Query: 65  SYEAEALLFAADRAEHVKKVILPALEKGKVVICDRYLYSSLAYQW-ARGLSLEWLMQ--- 120
           S  AE LLF A RA+H+++ ILPALE GK VICDR+  S++ YQ  A GL   ++     
Sbjct: 58  SSYAELLLFLAARAQHIQEKILPALESGKTVICDRFHDSTIVYQGIAGGLGEAFVTDLCY 117

Query: 121 --INSFAPRPDLAILLDLPVKESIRRTKARGNMSEFD-KLLELQRKVRMNYLKLAEMFKE 177
             +      PD+  LLDLP KE + R   + N+  F+ K     R  R  ++ LAE   +
Sbjct: 118 RVVGDEPFLPDITFLLDLPEKEGLLRKTRQKNLDRFEQKPTSFHRAAREGFISLAERSPD 177

Query: 178 -MRIVNAMASVE 188
             +I++A+   E
Sbjct: 178 RYKILDALLPTE 189


>sp|P37537|KTHY_BACSU THYMIDYLATE KINASE (DTMP KINASE) >gi|2127026|pir||S66058
           thymidylate kinase tmk - Bacillus subtilis
           >gi|467418|dbj|BAA05264.1| (D26185) unknown [Bacillus
           subtilis] >gi|2632295|emb|CAB11804.1| (Z99104)
           thymidylate kinase [Bacillus subtilis]
           Length = 212
           
 Score =  109 bits (271), Expect = 2e-23
 Identities = 71/212 (33%), Positives = 121/212 (56%), Gaps = 15/212 (7%)

Query: 1   MRGYFVVLEGIDGSGKTTQAKLLAEWFEEQGWDVLLTKEPTDTEFGRLIRELVL-KNSII 59
           M G F+  EG +G+GKTT  + +      +G  V+ T+EP   +    IRE++L +N+I+
Sbjct: 1   MSGLFITFEGPEGAGKTTVLQEIKNILTAEGLQVMATREPGGIDIAEQIREVILNENNIL 60

Query: 60  DGSRISYEAEALLFAADRAEHVKKVILPALEKGKVVICDRYLYSSLAYQ-WARGLSLEWL 118
               +  + EALL+AA R +H+ + + PALE+G +V+CDR++ S LAYQ +ARGL ++ +
Sbjct: 61  ----MDPKTEALLYAAARRQHLVEKVKPALEQGFIVLCDRFIDSPLAYQGYARGLGIDEV 116

Query: 119 MQINSFA---PRPDLAILLDLPVKESIRRTKARG----NMSEFDKLLELQRKVRMNYLKL 171
           + IN FA     P + +   +  +E ++R  A G    N  + +K L+   KV+  Y +L
Sbjct: 117 LSINEFAIGDMMPHVTVYFSIDPEEGLKRIYANGSREKNRLDLEK-LDFHTKVQEGYQEL 175

Query: 172 AEMFKE-MRIVNAMASVEEVHEDIVALVKHEL 202
            + F E    V+A  S + V +D++ ++   L
Sbjct: 176 MKRFPERFHSVDAGQSKDLVVQDVLKVIDEAL 207


>sp|O26009|KTHY_HELPY THYMIDYLATE KINASE (DTMP KINASE) >gi|7434648|pir||B64704
           thymidylate kinase - Helicobacter pylori (strain 26695)
           >gi|2314650|gb|AAD08513.1| (AE000647) thymidylate kinase
           (tmk) [Helicobacter pylori 26695]
           Length = 191
           
 Score =  109 bits (271), Expect = 2e-23
 Identities = 73/201 (36%), Positives = 114/201 (56%), Gaps = 20/201 (9%)

Query: 5   FVVLEGIDGSGKTTQAKLLAEWFEEQGWDVLLTKEPTDTEFGRLIRELVLKNSIIDGSRI 64
           +VVLEG+DG+GK+TQ +LL + F+    + L TKEP  T  G  +R + L  +I      
Sbjct: 2   YVVLEGVDGAGKSTQVELLKDRFK----NALFTKEPGGTRMGESLRRIALNENI------ 51

Query: 65  SYEAEALLFAADRAEHVKKVILPALEKGKVVICDRYLYSSLAYQWARGLSLEWLMQINSF 124
           S  A A LF +DRAEH + VI PAL++ K++I DR L S +AY     L L  L+   S 
Sbjct: 52  SELARAFLFLSDRAEHTESVIKPALKEKKLIISDRSLISGMAYSQFSSLELN-LLATQSV 110

Query: 125 APRPDLAILLDLPVKESIRRTKARGNMSE-----FDKLLELQRKVRMNYLKLAEMFK-EM 178
            P   + +L+D   KE +++  +  ++ +      +KLL +Q+K++ +   L E F  E+
Sbjct: 111 LPAKIILLLID---KEGLKQRLSLKSLDKIENQGIEKLLHIQQKLKTHAYALQEKFGCEV 167

Query: 179 RIVNAMASVEEVHEDIVALVK 199
             ++A  SV+ +HE I A +K
Sbjct: 168 LELDAKESVKNLHEKIAAFIK 188


>sp|O27793|KTHY_METTH PROBABLE THYMIDYLATE KINASE (DTMP KINASE) >gi|7434640|pir||F69102
           thymidylate kinase - Methanobacterium
           thermoautotrophicum  (strain Delta H)
           >gi|2622895|gb|AAB86231.1| (AE000932) thymidylate kinase
           [Methanobacterium thermoautotrophicum]
           Length = 194
           
 Score =  108 bits (268), Expect = 4e-23
 Identities = 79/191 (41%), Positives = 101/191 (52%), Gaps = 15/191 (7%)

Query: 5   FVVLEGIDGSGKTTQAKLLAEWFEEQGWDVLLTKEPTDTEFGRLIRELVLKNSIIDGSRI 64
           ++  EGIDGSGKTT A L A W  E G+ V   +EPTD+  G LIR ++   S  D    
Sbjct: 2   YICFEGIDGSGKTTHAALTASWLRENGYMVHEVREPTDSNIGSLIRSML---SSPDARTP 58

Query: 65  SYEAE-ALLFAADRAEHVKKVILPALEKGKVVICDRYLYSSLAYQWARGLSLEWLMQINS 123
             +   ALLFAADR     K+     E   VV+ DR  YSS+ YQ       EW+ +IN 
Sbjct: 59  DVQRMLALLFAADRLTLRSKIEGDWAE--DVVVSDRCYYSSMVYQGPE----EWVCEINR 112

Query: 124 FAPRPDLAILLDLPVKESIRRTKARGNMSEFDKLLELQRKVRMNYLKLAEMFKEMRIVNA 183
           FAPRPD+ ILLD+ V+ ++ R    G   EF+  L L   VR  YL+LA+       VNA
Sbjct: 113 FAPRPDVVILLDIDVEVAMERC---GGTDEFEDPLYL-AGVRERYLELADK-NGFYTVNA 167

Query: 184 MASVEEVHEDI 194
              V  +  DI
Sbjct: 168 ERGVNLIQRDI 178


>sp|P37345|KTHY_ECOLI THYMIDYLATE KINASE (DTMP KINASE) >gi|2145538|pir||JC6006
           thymidylate kinase (EC 2.7.4.9) - Escherichia coli
           >gi|7434653|pir||G64853 dTMP kinase (EC 2.7.4.9)
           [validated] - Escherichia coli
           >gi|1244710|gb|AAB06878.1| (U41456) thymidylate kinase
           [Escherichia coli] >gi|1787340|gb|AAC74182.1| (AE000210)
           thymidylate kinase [Escherichia coli K12]
           >gi|4062665|dbj|BAA35905.1| (D90745) Thymidylate kinase
           (EC 2.7.4.9) [Escherichia coli]
           Length = 213
           
 Score =  107 bits (265), Expect = 9e-23
 Identities = 69/206 (33%), Positives = 110/206 (52%), Gaps = 6/206 (2%)

Query: 1   MRGYFVVLEGIDGSGKTTQAKLLAEWFEEQGW-DVLLTKEPTDTEFGRLIRELVLKNSII 59
           MR  ++V+EG++G+GKTT   ++ E  E+ G  D++ T+EP  T+    +R LVL    +
Sbjct: 1   MRSKYIVIEGLEGAGKTTARNVVVETLEQLGIRDMVFTREPGGTQLAEKLRSLVLDIKSV 60

Query: 60  DGSRISYEAEALLFAADRAEHVKKVILPALEKGKVVICDRYLYSSLAYQ-WARGLSLEWL 118
               I+ +AE L+F A R + V+ VI PAL  G  VI DR+  S+ AYQ   RG+    L
Sbjct: 61  GDEVITDKAEVLMFYAARVQLVETVIKPALANGTWVIGDRHDLSTQAYQGGGRGIDQHML 120

Query: 119 MQINSFAP---RPDLAILLDLPVKESIRRTKARGNMSEFD-KLLELQRKVRMNYLKLAEM 174
             +        RPDL + LD+  +  ++R +ARG +   + +  +   + R  YL+LA  
Sbjct: 121 ATLRDAVLGDFRPDLTLYLDVTPEVGLKRARARGELDRIEQESFDFFNRTRARYLELAAQ 180

Query: 175 FKEMRIVNAMASVEEVHEDIVALVKH 200
            K +  ++A   +E V + I   V H
Sbjct: 181 DKSIHTIDATQPLEAVMDAIRTTVTH 206


>sp|Q9RQJ9|KTHY_CAUCR THYMIDYLATE KINASE (DTMP KINASE)
           >gi|6318310|gb|AAF06831.1|AF099189_1 (AF099189)
           thymydilate kinase [Caulobacter crescentus]
           Length = 208
           
 Score =  106 bits (262), Expect = 2e-22
 Identities = 71/207 (34%), Positives = 117/207 (56%), Gaps = 9/207 (4%)

Query: 2   RGYFVVLEGIDGSGKTTQAKLLAEWFEEQGWDVLLTKEPTDTEFGRLIRELVLKNSIIDG 61
           +G+F+  EG +G+GK+TQ + LA+  +  G DV++T+EP  +     IREL++  +    
Sbjct: 3   QGFFISFEGGEGAGKSTQIRRLADRLKAAGHDVIVTREPGGSPGAEAIRELLVNGA---A 59

Query: 62  SRISYEAEALLFAADRAEHVKKVILPALEKGKVVICDRYLYSSLAYQWARG---LSLEWL 118
            R S   E+LL  A R +H+++VI P L +G VV+CDR+  S+ AYQ A G    SL   
Sbjct: 60  DRWSPVTESLLMYAARRDHIERVIRPGLARGAVVLCDRFADSTRAYQGAGGDAPASLIAA 119

Query: 119 MQINSFAPR-PDLAILLDLPVKESIRRTKARGNMSEFD-KLLELQRKVRMNYLKLAEMFK 176
           ++ +      P L ++LDLP +  ++R +ARG  + F+ K L    ++R  YL++A    
Sbjct: 120 LEEHVLGGTVPVLTLILDLPAEVGLQRAEARGGAARFESKGLAFHERLRAGYLEIARREP 179

Query: 177 EMRIV-NAMASVEEVHEDIVALVKHEL 202
           +  +V +A A ++ V   I  +V   L
Sbjct: 180 DRCVVIDADAELDAVTAAISDVVVQRL 206


>pdb|4TMK|A Chain A, Complex Of E. Coli Thymidylate Kinase With The Bisubstrate
           Inhibitor Tp5a >gi|6729850|pdb|5TMP|A Chain A, Complex
           Of E. Coli Thymidylate Kinase With The Bisubstrate
           Inhibitor Aztp5a
           Length = 213
           
 Score =  106 bits (262), Expect = 2e-22
 Identities = 68/206 (33%), Positives = 110/206 (53%), Gaps = 6/206 (2%)

Query: 1   MRGYFVVLEGIDGSGKTTQAKLLAEWFEEQGW-DVLLTKEPTDTEFGRLIRELVLKNSII 59
           MR  ++V+EG++G+GKTT   ++ E  E+ G  D++ T+EP  T+    +R L+L    +
Sbjct: 1   MRSKYIVIEGLEGAGKTTARNVVVETLEQLGIRDMVFTREPGGTQLAEKLRSLLLDIKSV 60

Query: 60  DGSRISYEAEALLFAADRAEHVKKVILPALEKGKVVICDRYLYSSLAYQ-WARGLSLEWL 118
               I+ +AE L+F A R + V+ VI PAL  G  VI DR+  S+ AYQ   RG+    L
Sbjct: 61  GDEVITDKAEVLMFYAARVQLVETVIKPALANGTWVIGDRHDLSTQAYQGGGRGIDQHML 120

Query: 119 MQINSFAP---RPDLAILLDLPVKESIRRTKARGNMSEFD-KLLELQRKVRMNYLKLAEM 174
             +        RPDL + LD+  +  ++R +ARG +   + +  +   + R  YL+LA  
Sbjct: 121 ATLRDAVLGDFRPDLTLYLDVTPEVGLKRARARGELDRIEQESFDFFNRTRARYLELAAQ 180

Query: 175 FKEMRIVNAMASVEEVHEDIVALVKH 200
            K +  ++A   +E V + I   V H
Sbjct: 181 DKSIHTIDATQPLEAVMDAIRTTVTH 206


>gb|AAA93511.1| (L37441) thymidine:thymidylate kinase:zeocin resistance fusion
           protein [Cloning vector pZEO-SG3]
           Length = 560
           
 Score =  105 bits (260), Expect = 4e-22
 Identities = 68/205 (33%), Positives = 109/205 (53%), Gaps = 6/205 (2%)

Query: 2   RGYFVVLEGIDGSGKTTQAKLLAEWFEEQGW-DVLLTKEPTDTEFGRLIRELVLKNSIID 60
           R  ++V+EG++G+GKTT   ++ E  E+ G  D++ T+EP  T+    +R LVL    + 
Sbjct: 217 RSKYIVIEGLEGAGKTTARNVVVETLEQLGIRDMVFTREPGGTQLAEKLRSLVLDIKSVG 276

Query: 61  GSRISYEAEALLFAADRAEHVKKVILPALEKGKVVICDRYLYSSLAYQ-WARGLSLEWLM 119
              I+ +AE L+F A R + V+ VI PAL  G  VI DR+  S+ AYQ   RG+    L 
Sbjct: 277 DEVITDKAEVLMFYAARVQLVETVIKPALANGTWVIGDRHDLSTQAYQGGGRGIDQHMLA 336

Query: 120 QINSFAP---RPDLAILLDLPVKESIRRTKARGNMSEFD-KLLELQRKVRMNYLKLAEMF 175
            +        RPDL + LD+  +  ++R +ARG +   + +  +   + R  YL+LA   
Sbjct: 337 TLRDAVLGDFRPDLTLYLDVTPEVGLKRARARGELDRIEQESFDFFNRTRARYLELAAQD 396

Query: 176 KEMRIVNAMASVEEVHEDIVALVKH 200
           K +  ++A   +E V + I   V H
Sbjct: 397 KSIHTIDATQPLEAVMDAIRTTVTH 421


>gb|AAA93513.1| (L37442) thymidylate:zeocin resistance protein:NDP kinase fusion
           protein [Cloning vector pZEO-SG4]
           Length = 494
           
 Score =  105 bits (260), Expect = 4e-22
 Identities = 68/205 (33%), Positives = 109/205 (53%), Gaps = 6/205 (2%)

Query: 2   RGYFVVLEGIDGSGKTTQAKLLAEWFEEQGW-DVLLTKEPTDTEFGRLIRELVLKNSIID 60
           R  ++V+EG++G+GKTT   ++ E  E+ G  D++ T+EP  T+    +R LVL    + 
Sbjct: 3   RSKYIVIEGLEGAGKTTARNVVVETLEQLGIRDMVFTREPGGTQLAEKLRSLVLDIKSVG 62

Query: 61  GSRISYEAEALLFAADRAEHVKKVILPALEKGKVVICDRYLYSSLAYQ-WARGLSLEWLM 119
              I+ +AE L+F A R + V+ VI PAL  G  VI DR+  S+ AYQ   RG+    L 
Sbjct: 63  DEVITDKAEVLMFYAARVQLVETVIKPALANGTWVIGDRHDLSTQAYQGGGRGIDQHMLA 122

Query: 120 QINSFAP---RPDLAILLDLPVKESIRRTKARGNMSEFD-KLLELQRKVRMNYLKLAEMF 175
            +        RPDL + LD+  +  ++R +ARG +   + +  +   + R  YL+LA   
Sbjct: 123 TLRDAVLGDFRPDLTLYLDVTPEVGLKRARARGELDRIEQESFDFFNRTRARYLELAAQD 182

Query: 176 KEMRIVNAMASVEEVHEDIVALVKH 200
           K +  ++A   +E V + I   V H
Sbjct: 183 KSIHTIDATQPLEAVMDAIRTTVTH 207


>pir||H81932 probable dTMP kinase (EC 2.7.4.9) NMA0869 [imported] - Neisseria
           meningitidis (group A strain Z2491)
           >gi|7379584|emb|CAB84149.1| (AL162754) putative
           thymidylate kinase [Neisseria meningitidis Z2491]
           Length = 206
           
 Score =  105 bits (260), Expect = 4e-22
 Identities = 68/200 (34%), Positives = 107/200 (53%), Gaps = 10/200 (5%)

Query: 1   MRGYFVVLEGIDGSGKTTQAKLLAEWFEEQGWDVLLTKEPTDTEFGRLIRELVLKNSIID 60
           M+  F+ L+GIDG+GK+T   ++  WFE +G  VL T+EP  T  G  +RE++L      
Sbjct: 1   MKPQFITLDGIDGAGKSTNLAVIKAWFERRGLPVLFTREPGGTPVGEALREILLNPETKA 60

Query: 61  GSRISYEAEALLFAADRAEHVKKVILPALEKGKVVICDRYLYSSLAYQ-WARGLSLEWLM 119
           G R    AE L+  A R +H++ VILPAL  G  V+ DR+  ++ AYQ   RG+  E + 
Sbjct: 61  GLR----AETLMMFAARMQHIEDVILPALSDGIHVVSDRFTDATFAYQGGGRGMPSEDIE 116

Query: 120 QINSFAP---RPDLAILLDLPVKESIRRTKARGNMSEFD-KLLELQRKVRMNYLKLAEMF 175
            +  +     RPDL +LLD+P++ S+ R         F+ +  +   +VR  YL  A   
Sbjct: 117 ILEHWVQGGLRPDLTLLLDVPLEVSMARIGQTREKDRFEQEQADFFMRVRSVYLNRAAAC 176

Query: 176 KE-MRIVNAMASVEEVHEDI 194
            E   ++++   ++EV   I
Sbjct: 177 PERYAVIDSNLGLDEVRNSI 196


>pir||B81173 thymidylate kinase NMB0670 [imported] - Neisseria meningitidis
           (group B strain MD58) >gi|7225896|gb|AAF41088.1|
           (AE002421) thymidylate kinase [Neisseria meningitidis
           MC58]
           Length = 206
           
 Score =  104 bits (257), Expect = 8e-22
 Identities = 67/200 (33%), Positives = 109/200 (54%), Gaps = 10/200 (5%)

Query: 1   MRGYFVVLEGIDGSGKTTQAKLLAEWFEEQGWDVLLTKEPTDTEFGRLIRELVLKNSIID 60
           M+  F+ L+GIDG+GK+T   ++  WFE +G  VL T+EP  T  G  +RE++L      
Sbjct: 1   MKPQFITLDGIDGAGKSTNLAVIKAWFERRGLPVLFTREPGGTPVGEALREILLNPETKA 60

Query: 61  GSRISYEAEALLFAADRAEHVKKVILPALEKGKVVICDRYLYSSLAYQ-WARGLSLEWLM 119
           G R    AE L+  A R +H+++VILPAL  G  V+ DR+  ++ AYQ   RG+  E + 
Sbjct: 61  GLR----AETLMMFAARMQHIEEVILPALSDGIHVVSDRFTDATFAYQGGGRGMPSEDIE 116

Query: 120 QINSFAP---RPDLAILLDLPVKESIRRTKARGNMSEFD-KLLELQRKVRMNYLKLAEMF 175
            +  +     +PDL +LLD+P++ S+ R         F+ +  +   +VR  YL  A   
Sbjct: 117 ILEHWVQGGLKPDLTLLLDVPLEVSMARIGQTREKDRFEQEQADFFMRVRGVYLDRAAAC 176

Query: 176 KE-MRIVNAMASVEEVHEDI 194
            E   ++++  +++EV   I
Sbjct: 177 PERYAVIDSNRNLDEVRNSI 196


>sp|Q9ZJE5|KTHY_HELPJ THYMIDYLATE KINASE (DTMP KINASE) >gi|7434649|pir||B71814
           thymidylate kinase - Helicobacter pylori (strain J99)
           >gi|4155994|gb|AAD06956.1| (AE001560) THYMIDYLATE KINASE
           [Helicobacter pylori J99]
           Length = 191
           
 Score =  104 bits (256), Expect = 1e-21
 Identities = 69/201 (34%), Positives = 113/201 (55%), Gaps = 20/201 (9%)

Query: 5   FVVLEGIDGSGKTTQAKLLAEWFEEQGWDVLLTKEPTDTEFGRLIRELVLKNSIIDGSRI 64
           +VVLEG+DG+GK+TQ  LL + F+    + L TKEP  T  G  +R + L  +I      
Sbjct: 2   YVVLEGVDGAGKSTQVGLLKDRFK----NALFTKEPGGTRMGESLRRIALNENI------ 51

Query: 65  SYEAEALLFAADRAEHVKKVILPALEKGKVVICDRYLYSSLAYQWARGLSLEWLMQINSF 124
           S  A A LF +DRAEH++ VI PAL++ K++I DR L S +AY     L L  L+   S 
Sbjct: 52  SELARAFLFLSDRAEHIESVIKPALKEKKLIISDRSLISGMAYSQFSSLELN-LLATQSV 110

Query: 125 APRPDLAILLDLPVKESIRRTKARGNMSE-----FDKLLELQRKVRMNYLKLAEMFK-EM 178
            P   + +L++   KE++++  +  ++ +      +KLL +Q+K++ +   L E F  E+
Sbjct: 111 LPEKIILLLIN---KENLKQRLSLKSLDKIENQGIEKLLTIQQKLKTHAYALQEKFGCEV 167

Query: 179 RIVNAMASVEEVHEDIVALVK 199
             ++A  S + +HE I   ++
Sbjct: 168 LELDAQKSAKNLHEKIATFIE 188


>sp|O69169|KTHY_YERPE THYMIDYLATE KINASE (DTMP KINASE) >gi|3176887|gb|AAC18855.1|
           (AF065312) thymidylate kinase [Yersinia pestis]
           Length = 212
           
 Score =  102 bits (253), Expect = 2e-21
 Identities = 66/200 (33%), Positives = 106/200 (53%), Gaps = 8/200 (4%)

Query: 1   MRGYFVVLEGIDGSGKTTQAKLLAEWFEEQGW-DVLLTKEPTDTEFGRLIRELVLKNSII 59
           M   F+V+EG++G+GKTT    +      QG  D++ T+EP  T     +R+L+ +   I
Sbjct: 1   MNSKFIVIEGLEGAGKTTTRDTVVAVLRAQGINDIVFTREPGGTPLAEKLRDLIKQG--I 58

Query: 60  DGSRISYEAEALLFAADRAEHVKKVILPALEKGKVVICDRYLYSSLAYQ-WARGLSLEWL 118
           DG  ++ +AE L+  A R + V+ VI PAL +G  V+ DR+  SS AYQ   RG+  + +
Sbjct: 59  DGEVLTDKAEVLMLYAARVQLVENVIKPALARGSWVVGDRHDLSSQAYQGGGRGIDSQLM 118

Query: 119 MQINSFAP---RPDLAILLDLPVKESIRRTKARGNMSEFD-KLLELQRKVRMNYLKLAEM 174
             +        RPDL + LDLP    + R +ARG +   + + L    + R  YL+LA  
Sbjct: 119 ASLRDTVLGEFRPDLTLYLDLPPAVGLARARARGELDRIEQESLAFFERTRARYLELAAS 178

Query: 175 FKEMRIVNAMASVEEVHEDI 194
              ++ ++A   +E+V   I
Sbjct: 179 DASIKTIDASQPIEQVSASI 198


>pir||S76121 hypothetical protein - Synechocystis sp. (strain PCC 6803)
           >gi|1001473|dbj|BAA10099.1| (D63999) hypothetical
           protein [Synechocystis sp.]
           Length = 236
           
 Score =  101 bits (250), Expect = 5e-21
 Identities = 73/216 (33%), Positives = 113/216 (51%), Gaps = 18/216 (8%)

Query: 1   MRGYFVVLEGIDGSGKTTQAKLLAEWFEEQGWDVLLTKEPTDTEFGRLIRELVLKNSIID 60
           M   F+VLEGIDGSGKTTQ  LL   F+ QG   +L+ EPT+   GRLIR+ +  +    
Sbjct: 25  MAALFIVLEGIDGSGKTTQGDLLLAHFQRQGLAAVLSPEPTNGPVGRLIRQALQGDLFTY 84

Query: 61  GSRISYEAE-ALLFAADRAEHVKKV---ILPALEKGKVVICDRYLYSSLAYQWARGLSLE 116
                +EA+   LFAADR  H+      +   L +   VI  RY +SSLAY        E
Sbjct: 85  NDARQFEAQMGYLFAADRHYHLYHPGDGVEAKLAQQCHVITTRYYFSSLAYNCHTEADWE 144

Query: 117 WLMQINSFAPRPDLAILLDLPVKESIRRTKARGNM---------SEFDKLLELQRKVRMN 167
           ++ ++N   P+PD  I LDLPV  +++R   R  +          + +KL+ + R    N
Sbjct: 145 FVQRLNQSFPQPDWVIYLDLPVDLALQRLGDRQQLEDQAPRECYEQREKLISVHR----N 200

Query: 168 YLKLAEMFK-EMRIVNAMASVEEVHEDIVALVKHEL 202
           Y ++   ++ ++  ++A   VE++H+ I+  V+  L
Sbjct: 201 YDRIFAHYQGQLCRLDASLPVEQLHQAIITKVEEML 236


>sp|Q55593|KTHY_SYNY3 THYMIDYLATE KINASE (DTMP KINASE)
           Length = 212
           
 Score =  101 bits (250), Expect = 5e-21
 Identities = 73/216 (33%), Positives = 113/216 (51%), Gaps = 18/216 (8%)

Query: 1   MRGYFVVLEGIDGSGKTTQAKLLAEWFEEQGWDVLLTKEPTDTEFGRLIRELVLKNSIID 60
           M   F+VLEGIDGSGKTTQ  LL   F+ QG   +L+ EPT+   GRLIR+ +  +    
Sbjct: 1   MAALFIVLEGIDGSGKTTQGDLLLAHFQRQGLAAVLSPEPTNGPVGRLIRQALQGDLFTY 60

Query: 61  GSRISYEAE-ALLFAADRAEHVKKV---ILPALEKGKVVICDRYLYSSLAYQWARGLSLE 116
                +EA+   LFAADR  H+      +   L +   VI  RY +SSLAY        E
Sbjct: 61  NDARQFEAQMGYLFAADRHYHLYHPGDGVEAKLAQQCHVITTRYYFSSLAYNCHTEADWE 120

Query: 117 WLMQINSFAPRPDLAILLDLPVKESIRRTKARGNM---------SEFDKLLELQRKVRMN 167
           ++ ++N   P+PD  I LDLPV  +++R   R  +          + +KL+ + R    N
Sbjct: 121 FVQRLNQSFPQPDWVIYLDLPVDLALQRLGDRQQLEDQAPRECYEQREKLISVHR----N 176

Query: 168 YLKLAEMFK-EMRIVNAMASVEEVHEDIVALVKHEL 202
           Y ++   ++ ++  ++A   VE++H+ I+  V+  L
Sbjct: 177 YDRIFAHYQGQLCRLDASLPVEQLHQAIITKVEEML 212


>sp|P47252|KTHY_MYCGE THYMIDYLATE KINASE (DTMP KINASE) >gi|1361866|pir||F64200
           thymidylate kinase (CDC8) homolog - Mycoplasma
           genitalium >gi|1045674|gb|AAC71222.1| (U39679)
           thymidylate kinase (tmk) [Mycoplasma genitalium]
           Length = 210
           
 Score =  101 bits (248), Expect = 9e-21
 Identities = 68/207 (32%), Positives = 114/207 (54%), Gaps = 16/207 (7%)

Query: 2   RGYFVVLEGIDGSGKTTQAKLLAEWFEEQ--GWDVLLTKEPTDTEFGRLIRELVLKNSII 59
           +G FVV+EG+DG+GKT   +   + +  +   + +  T+EP  T     IR+L+L  ++ 
Sbjct: 3   KGVFVVIEGVDGAGKTALIEGFKKLYPTKFLNYQLTYTREPGGTLLAEKIRQLLLNETM- 61

Query: 60  DGSRISYEAEALLFAADRAEHVKKVILPALEKGKVVICDRYLYSSLAYQ-WARGLSLEWL 118
                    EA LFAA R EH+ K+I PA+EK ++VI DR+++SS AYQ  ++ + ++ +
Sbjct: 62  -----EPLTEAYLFAAARTEHISKLIKPAIEKEQLVISDRFVFSSFAYQGLSKKIGIDTV 116

Query: 119 MQINSFAPR---PDLAILLDLPVKESIRRTKARGNMSEFDKLLELQR---KVRMNYLKLA 172
            QIN  A R   P+   +LD   KE+++R + RGN +  D+ ++ +     VR  YL L 
Sbjct: 117 KQINHHALRNMMPNFTFILDCNFKEALQRMQKRGNDNLLDEFIKGKNDFDTVRSYYLSLV 176

Query: 173 EMFKEMRIVNAMASVEEVHEDIVALVK 199
           +  K   ++N     E + + I  L +
Sbjct: 177 DK-KNCFLINGDNKQEHLEKFIELLTR 202


>sp|O84191|KTHY_CHLTR THYMIDYLATE KINASE (DTMP KINASE) >gi|7434652|pir||E71546 probable
           thymidylate kinase - Chlamydia trachomatis  (serotype D,
           strain UW3/Cx) >gi|3328593|gb|AAC67780.1| (AE001292)
           Thymidylate Kinase [Chlamydia trachomatis]
           Length = 203
           
 Score = 98.7 bits (242), Expect = 5e-20
 Identities = 68/206 (33%), Positives = 117/206 (56%), Gaps = 16/206 (7%)

Query: 5   FVVLEGIDGSGKTTQAKLLAEWFEEQGWDVLLTKEPTDTEFGRLIRELVLKNSIIDGSRI 64
           F+V+EG +G+GKT   + L++   E+G +++ T+EP     G  +R L+L        +I
Sbjct: 2   FIVVEGGEGAGKTQFIQALSKRLIEEGREIVTTREPGGCSLGDSVRGLLLDPE----QKI 57

Query: 65  SYEAEALLFAADRAEHVKKVILPALEKGKVVICDRYLYSSLAYQW-ARGLSLEWLMQ--- 120
           S  AE LLF A RA+H+++ I+PAL+ GK VI DR+  S++ YQ  A GL   ++     
Sbjct: 58  SPYAELLLFLAARAQHIQEKIIPALKSGKTVISDRFHDSTIVYQGIAGGLGESFVTNLCY 117

Query: 121 --INSFAPRPDLAILLDLPVKESIRRTKARGNMSEFDKLLEL-QRKVRMNYLKLAEMFKE 177
             +      PD+  LLD+P +E + R   + ++ +F++  ++  R VR  +L LAE   +
Sbjct: 118 HVVGDKPFLPDITFLLDIPAREGLLRKARQKHLDKFEQKPQIFHRSVREGFLALAEKAPD 177

Query: 178 -MRIVNAM----ASVEEVHEDIVALV 198
             ++++A+    ASV++    I AL+
Sbjct: 178 RYKVLDALLPTEASVDQALLQIRALI 203


>pir||T41553 thymidylate kinase - fission yeast (Schizosaccharomyces pombe)
           >gi|3192027|emb|CAA19357.1| (AL023794) thymidylate
           kinase [Schizosaccharomyces pombe]
           Length = 210
           
 Score = 98.3 bits (241), Expect = 6e-20
 Identities = 71/204 (34%), Positives = 112/204 (54%), Gaps = 14/204 (6%)

Query: 2   RGYFVVLEGIDGSGKTTQAKLLAEWFEEQGWDVLLTKEPT-DTEFGRLIRELVLKNSIID 60
           RG  +V+EG+D SGK+TQ +LL +    Q     L K P   T  G+ I +  LK S+  
Sbjct: 6   RGRLIVIEGLDRSGKSTQCQLLVDKLISQHEKAELFKFPDRTTAIGKKIDDY-LKESV-- 62

Query: 61  GSRISYEAEALLFAADRAEHVKKVILPALEKGKVVICDRYLYSSLAYQWARGLSLEWLMQ 120
             +++ +   LLF+A+R E ++  I   + KG   I DRY +S +A+  A+GL  EW   
Sbjct: 63  --QLNDQVIHLLFSANRWETIQ-YIYEQINKGVTCILDRYAFSGIAFSAAKGLDWEWCKS 119

Query: 121 INSFAPRPDLAILLDLPVKESIRRTKARGNMSEFDKLLELQRKVRMNYLKLAEMFKEMRI 180
            +   PRPDL I L+  V   I  T+ +     ++K +E+Q KV  N+ +L + F+E  +
Sbjct: 120 PDRGLPRPDLVIFLN--VDPRIAATRGQYGEERYEK-IEMQEKVLKNFQRLQKEFREEGL 176

Query: 181 ----VNAMASVEEVHEDIVALVKH 200
               ++A +S+E+VH  IV LV +
Sbjct: 177 EFITLDASSSLEDVHSQIVDLVSN 200


>sp|Q9Z8R5|KTHY_CHLPN THYMIDYLATE KINASE (DTMP KINASE) >gi|7434651|pir||F72098
           thymidylate kinase CP0486 [imported] - Chlamydophila
           pneumoniae (strains CWL029 and AR39)
           >gi|4376546|gb|AAD18422.1| (AE001612) Thymidylate Kinase
           [Chlamydophila pneumoniae CWL029]
           >gi|7189404|gb|AAF38316.1| (AE002210) thymidylate kinase
           [Chlamydophila pneumoniae AR39]
           >gi|8978647|dbj|BAA98483.1| (AP002546) thymidylate
           kinase [Chlamydophila pneumoniae J138]
           Length = 206
           
 Score = 97.9 bits (240), Expect = 8e-20
 Identities = 68/208 (32%), Positives = 112/208 (53%), Gaps = 12/208 (5%)

Query: 5   FVVLEGIDGSGKTTQAKLLAEWFEEQGWDVLLTKEPTDTEFGRLIRELVLKNSIIDGSRI 64
           F+V+EG +GSGK++ AK L +    Q   VLLT+EP     G  +R+L+L+   ++ SR 
Sbjct: 2   FIVIEGGEGSGKSSLAKALGDQLVAQDRKVLLTREPGGCLIGERLRDLILEPPHLELSRC 61

Query: 65  SYEAEALLFAADRAEHVKKVILPALEKGKVVICDRYLYSSLAYQW-ARGLSLEWLMQINS 123
               E  LF   RA+H+++VI+PAL  G +VIC+R+  S++ YQ  A GL  +++  + S
Sbjct: 62  ---CELFLFLGSRAQHIQEVIIPALRDGYIVICERFHDSTIVYQGIAEGLGADFVADLCS 118

Query: 124 --FAPR---PDLAILLDLPVKESIRRTKARGNMSEFDKL-LELQRKVRMNYLKLAEMFKE 177
               P    P+  +LLD+P    ++R   +    +F+K  L    ++R  +L LA     
Sbjct: 119 KVVGPTPFLPNFVLLLDIPADIGLQRKHRQKVFDKFEKKPLSYHNRIREGFLSLASADPS 178

Query: 178 MRIVNAMASVEEVHEDIVALVKHELLGL 205
             +V  + + E +   I  ++ H  LGL
Sbjct: 179 RYLV--LDARESLASLIDKVMLHTQLGL 204


>pir||A64153 dTMP kinase (EC 2.7.4.9) - Haemophilus influenzae (strain Rd KW20)
           Length = 237
           
 Score = 96.3 bits (236), Expect = 2e-19
 Identities = 65/206 (31%), Positives = 110/206 (52%), Gaps = 9/206 (4%)

Query: 1   MRGYFVVLEGIDGSGKTTQAKLLAEWFEEQG-WDVLLTKEPTDTEFGRLIRELVLKNSII 59
           M+G F+V+EG++G+GK++  + +     E G  DV+ T+EP  T     +R L+   +  
Sbjct: 28  MKGKFIVIEGLEGAGKSSAHQSVVRVLHELGIQDVVFTREPGGTPLAEKLRHLIKHET-- 85

Query: 60  DGSRISYEAEALLFAADRAEHVKKVILPALEKGKVVICDRYLYSSLAYQ-WARGLSLEWL 118
               ++ +AE L+  A R + V+ VI PAL +GK V+ DR+  SS AYQ   R L   ++
Sbjct: 86  -EEPVTDKAELLMLYAARIQLVENVIKPALMQGKWVVGDRHDMSSQAYQGGGRQLDPHFM 144

Query: 119 MQINSFAP---RPDLAILLDLPVKESIRRTKARGNMSEFDKL-LELQRKVRMNYLKLAEM 174
           + +         PDL I LD+     + R + RG +   +++ L+   + R  YL+L + 
Sbjct: 145 LTLKETVLGNFEPDLTIYLDIDPSVGLARARGRGELDRIEQMDLDFFHRTRARYLELVKD 204

Query: 175 FKEMRIVNAMASVEEVHEDIVALVKH 200
             +  ++NA  S+E V  DI + VK+
Sbjct: 205 NPKAVVINAEQSIELVQADIESAVKN 230


>sp|P44719|KTHY_HAEIN THYMIDYLATE KINASE (DTMP KINASE) >gi|1573430|gb|AAC22114.1|
           (U32728) thymidylate kinase [Haemophilus influenzae Rd]
           Length = 210
           
 Score = 96.3 bits (236), Expect = 2e-19
 Identities = 65/206 (31%), Positives = 110/206 (52%), Gaps = 9/206 (4%)

Query: 1   MRGYFVVLEGIDGSGKTTQAKLLAEWFEEQG-WDVLLTKEPTDTEFGRLIRELVLKNSII 59
           M+G F+V+EG++G+GK++  + +     E G  DV+ T+EP  T     +R L+   +  
Sbjct: 1   MKGKFIVIEGLEGAGKSSAHQSVVRVLHELGIQDVVFTREPGGTPLAEKLRHLIKHET-- 58

Query: 60  DGSRISYEAEALLFAADRAEHVKKVILPALEKGKVVICDRYLYSSLAYQ-WARGLSLEWL 118
               ++ +AE L+  A R + V+ VI PAL +GK V+ DR+  SS AYQ   R L   ++
Sbjct: 59  -EEPVTDKAELLMLYAARIQLVENVIKPALMQGKWVVGDRHDMSSQAYQGGGRQLDPHFM 117

Query: 119 MQINSFAP---RPDLAILLDLPVKESIRRTKARGNMSEFDKL-LELQRKVRMNYLKLAEM 174
           + +         PDL I LD+     + R + RG +   +++ L+   + R  YL+L + 
Sbjct: 118 LTLKETVLGNFEPDLTIYLDIDPSVGLARARGRGELDRIEQMDLDFFHRTRARYLELVKD 177

Query: 175 FKEMRIVNAMASVEEVHEDIVALVKH 200
             +  ++NA  S+E V  DI + VK+
Sbjct: 178 NPKAVVINAEQSIELVQADIESAVKN 203


>sp|Q9YA48|KTHY_AERPE PROBABLE THYMIDYLATE KINASE (DTMP KINASE) >gi|7434643|pir||E72514
           hypothetical protein APE2090 - Aeropyrum pernix (strain
           K1) >gi|5105789|dbj|BAA81101.1| (AP000063) 208aa long
           hypothetical protein [Aeropyrum pernix]
           Length = 208
           
 Score = 96.3 bits (236), Expect = 2e-19
 Identities = 74/208 (35%), Positives = 106/208 (50%), Gaps = 14/208 (6%)

Query: 6   VVLEGIDGSGKTTQAKLLAEWFEEQGWDVLLTKEPTDTEFGRLIRELVLKNSIIDGSRIS 65
           V LEGIDGSG +T ++LL       G    L KEPT+   GRLIR  +     +D     
Sbjct: 4   VALEGIDGSGVSTHSRLLHARLAGAGVKSCLWKEPTEGPVGRLIRGFLRSTEGVDS---- 59

Query: 66  YEAEALLFAADRAEHVK-KVILPALEKGKVVICDRYLYSSLAYQWARGLSLEWLMQINSF 124
            +  ALLFAADR   ++  V+       +V++ DRY YSSLAYQ   G  LEW+  +N  
Sbjct: 60  -DLMALLFAADRLWGLRLGVVERCGGSPEVLVVDRYKYSSLAYQGV-GSGLEWVDAVNRK 117

Query: 125 APRPDLAILLDLPVKESIRRTKARGNMSEFD--KLLELQRKVRMNYLKLAEM--FKEMRI 180
           AP  ++ + +D+P + ++RR  AR     F+  + LE  + +    L+LA     K +R+
Sbjct: 118 APEAEILVYIDVPTEVALRRITARERREVFETPEFLERVKSMYEEVLRLARARGVKVIRV 177

Query: 181 VNAMASVEEVHEDI---VALVKHELLGL 205
                 VE   ED+   +A    E LGL
Sbjct: 178 EGVRGGVERGIEDVQGEIAERVFEALGL 205


>pir||A82128 thymidylate kinase VC2016 [imported] - Vibrio cholerae  (group O1
           strain N16961) >gi|9656560|gb|AAF95164.1| (AE004276)
           thymidylate kinase [Vibrio cholerae]
           Length = 212
           
 Score = 95.2 bits (233), Expect = 5e-19
 Identities = 63/200 (31%), Positives = 106/200 (52%), Gaps = 8/200 (4%)

Query: 1   MRGYFVVLEGIDGSGKTTQAKLLAEWFEEQGWD-VLLTKEPTDTEFGRLIRELVLKNSII 59
           M   F+V+EG++G+GK+T  +++ E  ++ G D +  T+EP  T     +R LV +    
Sbjct: 1   MNAKFIVIEGLEGAGKSTAIQVVVETLQQNGIDHITRTREPGGTLLAEKLRALVKEEH-- 58

Query: 60  DGSRISYEAEALLFAADRAEHVKKVILPALEKGKVVICDRYLYSSLAYQ-WARGLSLEWL 118
            G  +    E LL  A R + V+ VI PAL +G+ V+ DR+  SS AYQ   R ++   +
Sbjct: 59  PGEELQDITELLLVYAARVQLVENVIKPALARGEWVVGDRHDMSSQAYQGGGRQIAPSTM 118

Query: 119 MQINSFAP---RPDLAILLDLPVKESIRRTKARGNMSEFDKL-LELQRKVRMNYLKLAEM 174
             +   A    +PDL + LD+  K  + R + RG +   +K+ +    + R  YL+LA  
Sbjct: 119 QSLKQTALGDFKPDLTLYLDIDPKLGLERARGRGELDRIEKMDISFFERARERYLELANS 178

Query: 175 FKEMRIVNAMASVEEVHEDI 194
              + +++A  S+E+V  DI
Sbjct: 179 DDSVVMIDAAQSIEQVTADI 198


>sp|Q9ZCN9|KTHY_RICPR THYMIDYLATE KINASE (DTMP KINASE) >gi|7434650|pir||G71674
           thymidylate kinase (tmk) RP684 - Rickettsia prowazekii
           >gi|3861221|emb|CAA15121.1| (AJ235272) THYMIDYLATE
           KINASE (tmk) [Rickettsia prowazekii]
           Length = 203
           
 Score = 94.8 bits (232), Expect = 7e-19
 Identities = 64/201 (31%), Positives = 108/201 (52%), Gaps = 19/201 (9%)

Query: 2   RGYFVVLEGIDGSGKTTQAKLLAEWFEEQGWDVLLTKEPTDTEFGRLIRELVLKNSIIDG 61
           +G F+  EG+DG GK+TQ+K+L E+ + Q   V+LT+E   T     +RE+++   ++  
Sbjct: 6   QGKFITFEGVDGIGKSTQSKMLYEYLKSQKIPVILTREVGGTTVAEKMREILVNEELLPM 65

Query: 62  SRISYEAEALLFAADRAEHVKKVILPALEKGKVVICDRYLYSSLAYQWARGLSLEWLMQI 121
           S      E L   A R +H+ + I+PAL+ G +VICDR++ S+  YQ   GL LE  + +
Sbjct: 66  S------ELLQAMAARYDHMARKIIPALKDGYIVICDRFIDSTACYQ---GLELENGIDL 116

Query: 122 -----NSFAP--RPDLAILLDLPVKESIRRTKARGNMSEFD-KLLELQRKVRMNYLKLAE 173
                 +  P   PD+   +D+    +I+R  AR   ++FD + ++  +K+   + +L+ 
Sbjct: 117 VYSLHKTLMPSLMPDITFFIDVEPHTAIKRVNARNMSNKFDIRSIDFYKKIYTCFKELSN 176

Query: 174 MFKE--MRIVNAMASVEEVHE 192
            F E    I  +  S  EVHE
Sbjct: 177 RFPERIKTIKASHLSPLEVHE 197


>gb|AAK41441.1| Thymidylate kinase  (tmK-2) [Sulfolobus solfataricus]
           Length = 213
           
 Score = 90.9 bits (222), Expect = 1e-17
 Identities = 62/208 (29%), Positives = 109/208 (51%), Gaps = 21/208 (10%)

Query: 1   MRGYFVVLEGIDGSGKTTQAKLLAEWFEEQGWDVLLTKEPTDTEFGRLIRELVLKNSIID 60
           MRG  +  EGIDGSGK++QA LL +W E +  DV LT+  +      +I+E   KN +  
Sbjct: 1   MRGLLIAFEGIDGSGKSSQAVLLKDWIEMRR-DVYLTEWNSSEWIHDIIKEAKKKNML-- 57

Query: 61  GSRISYEAEALLFAADRAEHVKKVILPALEKGKVVICDRYLYSSLAYQWARGLSLEWLMQ 120
            + I++   +L+ A D ++  ++ ILP L+ G VVICDRY+Y++ A    R +  +W+ +
Sbjct: 58  -TSITF---SLIHATDFSDRYERYILPMLKSGFVVICDRYVYTAYARDVVRNVDFDWVKR 113

Query: 121 INSFAPRPDLAILLDLPVK---ESIRRTKAR-----------GNMSEFDKLLELQRKVRM 166
           + SFA +P+    + +  +   E IR+ K +           G +   +  L+ Q ++  
Sbjct: 114 LYSFAIKPNFTFYIRVTPEIALERIRKAKRKIKPQEAGIDILGEIPLEEGFLKYQSRIVE 173

Query: 167 NYLKLAEMFKEMRIVNAMASVEEVHEDI 194
            Y K+A+       ++    +++V  DI
Sbjct: 174 IYDKIAKEESNFITIDGNRPLKDVQIDI 201


>pir||H82944 thymidylate kinase UU020 [imported] - Ureaplasma urealyticum
           >gi|6898965|gb|AAF30425.1|AE002101_8 (AE002101)
           thymidylate kinase [Ureaplasma urealyticum]
           Length = 233
           
 Score = 89.7 bits (219), Expect = 2e-17
 Identities = 70/213 (32%), Positives = 110/213 (50%), Gaps = 17/213 (7%)

Query: 2   RGYFVVLEGIDGSGKTTQAKLLAEWFEEQGW--DVLLTKEP--TDTEFGRLIRELVLKN- 56
           +G F+V EGIDG+GKT+  K L E  +E      + LT+EP   +     +IRE  LKN 
Sbjct: 18  KGLFIVFEGIDGAGKTSILKQLLEVLKEPKLVNKIFLTREPGGKNNNAAEMIREFFLKNL 77

Query: 57  SIIDGSRISYEAEALLFAADRAEHVKKVILPALEKGKVVICDRYLYSSLAYQW-ARGLSL 115
            + D   ++Y     L+A+ RAEHVKK I P LEK  +VI DR+++SS  YQ   +  SL
Sbjct: 78  EVFDPLTLAY-----LYASSRAEHVKKTINPHLEKDHIVISDRFVHSSYIYQGIVQNQSL 132

Query: 116 EWLMQINSFA---PRPDLAILLDLPVKESIRRTKAR-GNMSEFD-KLLELQRKVRMNYLK 170
           + + QIN  A      D     D+ V  ++ R K R  N + FD +  +   K+   Y  
Sbjct: 133 DVIYQINQQAIGELEIDYVFYFDVNVNNALNRMKNRFDNTNAFDSQNKQFYEKLLKQYPS 192

Query: 171 LAEMFKEMRIVNAMASVEEVHEDIVALVKHELL 203
           + +++ + + +       +   +++  VK +LL
Sbjct: 193 VFKVYNQPKKI-IFIDANKNENEVLCEVKEQLL 224


>sp|P75106|KTHY_MYCPN THYMIDYLATE KINASE (DTMP KINASE) >gi|2146665|pir||S73474
           thymidylate kinase - Mycoplasma pneumoniae (strain ATCC
           29342) >gi|1673808|gb|AAB95796.1| (AE000016) thymidylate
           kinase [Mycoplasma pneumoniae]
           Length = 210
           
 Score = 87.0 bits (212), Expect = 2e-16
 Identities = 54/166 (32%), Positives = 92/166 (54%), Gaps = 12/166 (7%)

Query: 2   RGYFVVLEGIDGSGKTTQAKLLAEWFEEQ--GWDVLLTKEPTDTEFGRLIRELVLKNSII 59
           +G FV +EG+DG+GKT   +   + F +   G+  L ++EP  T     IR L+L  ++ 
Sbjct: 3   QGVFVAIEGVDGAGKTVLLEAFKQRFPQSFLGFKTLFSREPGGTPLAEKIRALLLHEAM- 61

Query: 60  DGSRISYEAEALLFAADRAEHVKKVILPALEKGKVVICDRYLYSSLAYQ-WARGLSLEWL 118
                    EA LFAA R EHV+++I PAL++ ++VI DR+++SS AYQ   + + L+ +
Sbjct: 62  -----EPLTEAYLFAASRTEHVRQLIQPALQQKQLVIVDRFVWSSYAYQGLIKKVGLDVV 116

Query: 119 MQINSFA---PRPDLAILLDLPVKESIRRTKARGNMSEFDKLLELQ 161
            ++N+ A     PD   ++D   + ++ R   RG  +  D  ++ Q
Sbjct: 117 KKLNADAVGDSMPDFTFIVDCDFETALNRMAKRGQDNLLDNTVKKQ 162


>gb|AAA21719.1| (L16991) thymidylate kinase [Homo sapiens]
           Length = 212
           
 Score = 85.8 bits (209), Expect = 3e-16
 Identities = 61/198 (30%), Positives = 106/198 (52%), Gaps = 10/198 (5%)

Query: 2   RGYFVVLEGIDGSGKTTQAKLLAEWFEEQGWDVLLTKEP-TDTEFGRLIRELVLKNSIID 60
           RG  +VLEG+D +GK+TQ++ L E     G    L + P   TE G+L+   + K S ++
Sbjct: 5   RGALIVLEGVDRAGKSTQSRKLVEALCAAGHRAELLRFPERSTEIGKLLSSYLKKKSDVE 64

Query: 61  GSRISYEAEALLFAADRAEHVKKVILPALEKGKVVICDRYLYSSLAYQWAR-GLSLEWLM 119
              +      LLF+A+R E V  +I   L +G  ++ DRY +S +A+  A+   SL+W  
Sbjct: 65  DHSVH-----LLFSANRWEQV-PLIKEKLSQGVTLVVDRYAFSGVAFTGAKENFSLDWCK 118

Query: 120 QINSFAPRPDLAILLDLPVKESIRRTKARGNMSEFDKLLELQRKVRMNYLKLAEMFKEMR 179
           Q +   P+PDL + L L + ++ +R  A G+   ++     +R +R  +  + +     +
Sbjct: 119 QPDVGLPKPDLVLFLQLQLADAAKR-GAFGH-ERYENGAFQERALRCFHQLMKDTTLNWK 176

Query: 180 IVNAMASVEEVHEDIVAL 197
           +V+A  S+E VHE++  L
Sbjct: 177 MVDASKSIEAVHEELRVL 194


>gi|6912340 deoxythymidylate kinase (thymidylate kinase) [Homo sapiens]
           >gi|284071|pir||S26845 dTMP kinase (EC 2.7.4.9) - human
           >gi|37206|emb|CAA38528.1| (X54729) thymidylate kinase
           [Homo sapiens]
           Length = 211
           
 Score = 83.5 bits (203), Expect = 2e-15
 Identities = 59/197 (29%), Positives = 103/197 (51%), Gaps = 9/197 (4%)

Query: 2   RGYFVVLEGIDGSGKTTQAKLLAEWFEEQGWDVLLTKEPTDTEFGRLIRELVLKNSIIDG 61
           RG  +VLEG+D +GK+TQ++ L E         LL      TE G+L+   + K S ++ 
Sbjct: 5   RGALIVLEGVDRAGKSTQSRKLVEALSRGPPPELLRFPERSTEIGKLLSSYLQKKSDVED 64

Query: 62  SRISYEAEALLFAADRAEHVKKVILPALEKGKVVICDRYLYSSLAYQWAR-GLSLEWLMQ 120
             +      LLF+A+R E V  +I   L +G  ++ DRY +S +A+  A+   SL+W  Q
Sbjct: 65  HSVH-----LLFSANRWEQV-PLIKEKLSQGVTLVVDRYAFSGVAFTGAKENFSLDWCKQ 118

Query: 121 INSFAPRPDLAILLDLPVKESIRRTKARGNMSEFDKLLELQRKVRMNYLKLAEMFKEMRI 180
            +   P+PDL + L L + ++ +R  A G+   ++     +R +R  +  + +     ++
Sbjct: 119 PDVGLPKPDLVLFLQLQLADAAKR-GAFGH-ERYENGAFQERALRCFHQLMKDTTLNWKM 176

Query: 181 VNAMASVEEVHEDIVAL 197
           V+A   +E VHE++  L
Sbjct: 177 VDASKRLEAVHEELRVL 193


>sp|P23919|KTHY_HUMAN THYMIDYLATE KINASE (DTMP KINASE)
           Length = 212
           
 Score = 83.1 bits (202), Expect = 2e-15
 Identities = 60/198 (30%), Positives = 105/198 (52%), Gaps = 10/198 (5%)

Query: 2   RGYFVVLEGIDGSGKTTQAKLLAEWFEEQGWDVLLTKEP-TDTEFGRLIRELVLKNSIID 60
           RG  +VLEG+D +GK+TQ++ L E     G    L + P   TE G+L+   + K S ++
Sbjct: 5   RGALIVLEGVDRAGKSTQSRKLVEALCAAGHRAELLRFPERSTEIGKLLSSYLQKKSDVE 64

Query: 61  GSRISYEAEALLFAADRAEHVKKVILPALEKGKVVICDRYLYSSLAYQWAR-GLSLEWLM 119
              +      LLF+A+R E V  +I   L +G  ++ DRY +S +A+  A+   SL+W  
Sbjct: 65  DHSVH-----LLFSANRWEQV-PLIKEKLSQGVTLVVDRYAFSGVAFTGAKENFSLDWCK 118

Query: 120 QINSFAPRPDLAILLDLPVKESIRRTKARGNMSEFDKLLELQRKVRMNYLKLAEMFKEMR 179
           Q +   P+PDL + L L + ++ +R  A G+   ++     +R +R  +  + +     +
Sbjct: 119 QPDVGLPKPDLVLFLQLQLADAAKR-GAFGH-ERYENGAFQERALRCFHQLMKDTTLNWK 176

Query: 180 IVNAMASVEEVHEDIVAL 197
           +V+A   +E VHE++  L
Sbjct: 177 MVDASKRLEAVHEELRVL 194


>gb|AAG20116.1| (AE005090) thymidylate kinase; Tmk [Halobacterium sp. NRC-1]
           Length = 199
           
 Score = 83.1 bits (202), Expect = 2e-15
 Identities = 69/204 (33%), Positives = 103/204 (49%), Gaps = 20/204 (9%)

Query: 6   VVLEGIDGSGKTTQAKLLAEWFEEQGWDVLLTKEPTDTEFGRLIRELVLKNSIIDGSRIS 65
           V LEG+DGSGKTT  + L    ++    V  T EPTD+++G+ +R      S  D   I 
Sbjct: 3   VTLEGLDGSGKTTVWESLRASHDD---GVTFTAEPTDSQYGQAVRR---SESAADADPI- 55

Query: 66  YEAEALLFAADRAEHVKKVILPALEKGKVVICDRYLYSSLAYQWAR-----GLSLEWLMQ 120
             AE  LF AD A+H+ +V+ PAL++G VVI DRY  S  AYQ A        ++E++  
Sbjct: 56  --AELFLFTADHADHLSRVVSPALDRGDVVISDRYSDSRYAYQGATLADTVPRAMEYVRG 113

Query: 121 INS-FAPRPDLAILLDLPVKESIRRTKARGNMSEFDKLLELQRKVRMNYLKLAEMFKEMR 179
           I+  +   PD+ +  D+       R+   G  ++F+    L   VR NY +L +   E  
Sbjct: 114 IHQPWTRPPDVTLYFDVDPDTGAARS---GATNKFETAAFL-ADVRANYEQLIDYTPERF 169

Query: 180 I-VNAMASVEEVHEDIVALVKHEL 202
           + ++A  S E V  D  A +   L
Sbjct: 170 VRIDATQSPEAVIADAEAALADAL 193


>sp|P57434|KTHY_BUCAI THYMIDYLATE KINASE (DTMP KINASE) >gi|10039023|dbj|BAB13057.1|
           (AP001119) thymidylate kinase [Buchnera sp. APS]
           Length = 212
           
 Score = 81.9 bits (199), Expect = 5e-15
 Identities = 62/200 (31%), Positives = 105/200 (52%), Gaps = 8/200 (4%)

Query: 1   MRGYFVVLEGIDGSGKTTQAKLLAEWFEEQGW-DVLLTKEPTDTEFGRLIRELVLKNSII 59
           ++  F+V+EG++G+GKT     +    ++    +VLL ++P  T     IR L+ K    
Sbjct: 2   IKSKFIVIEGLEGAGKTNACICIKNLLKKNSIKNVLLVRQPGSTPIAEDIRRLIKKK--F 59

Query: 60  DGSRISYEAEALLFAADRAEHVKKVILPALEKGKVVICDRYLYSSLAYQ-WARGLSLEWL 118
           +   +  E E LL  A R + V+K I PAL+ G  VI DR+  SSLAYQ    G+  + +
Sbjct: 60  NDDNLIKETELLLMYAARIQLVEKKIKPALKNGIWVISDRHDLSSLAYQGGGLGIPKKII 119

Query: 119 MQINSFAPR---PDLAILLDLPVKESIRRTKARGNMSEFD-KLLELQRKVRMNYLKLAEM 174
            Q+ S       PDL I LD+  +  + R   R  +   + + L   +K R  YL+ +++
Sbjct: 120 YQLQSLFLNNFIPDLTIYLDVSPEIGLARALKRNPLDLIESRSLFFFKKTRRCYLEKSKL 179

Query: 175 FKEMRIVNAMASVEEVHEDI 194
            K+  I+NA  ++++V ++I
Sbjct: 180 DKKTIIINANLNIKKVTQNI 199


>gi|6322517 thymidylate kinase; Cdc8p [Saccharomyces cerevisiae]
           >gi|1170719|sp|P00572|KTHY_YEAST THYMIDYLATE KINASE
           (DTMP KINASE) >gi|2144430|pir||KIBYT8 dTMP kinase (EC
           2.7.4.9) - yeast (Saccharomyces cerevisiae)
           >gi|4558230|pdb|3TMK|A Chain A, Crystal Structure Of
           Yeast Thymidylate Kinase Complexed With The Bisubstrate
           Inhibitor Tp5a At 2.0 A Resolution: Implications For
           Catalysis And Azt Activation >gi|4558231|pdb|3TMK|B
           Chain B, Crystal Structure Of Yeast Thymidylate Kinase
           Complexed With The Bisubstrate Inhibitor Tp5a At 2.0 A
           Resolution: Implications For Catalysis And Azt
           Activation >gi|4558235|pdb|3TMK|F Chain F, Crystal
           Structure Of Yeast Thymidylate Kinase Complexed With The
           Bisubstrate Inhibitor Tp5a At 2.0 A Resolution:
           Implications For Catalysis And Azt Activation
           >gi|4558234|pdb|3TMK|E Chain E, Crystal Structure Of
           Yeast Thymidylate Kinase Complexed With The Bisubstrate
           Inhibitor Tp5a At 2.0 A Resolution: Implications For
           Catalysis And Azt Activation >gi|4558236|pdb|3TMK|G
           Chain G, Crystal Structure Of Yeast Thymidylate Kinase
           Complexed With The Bisubstrate Inhibitor Tp5a At 2.0 A
           Resolution: Implications For Catalysis And Azt
           Activation >gi|4558233|pdb|3TMK|D Chain D, Crystal
           Structure Of Yeast Thymidylate Kinase Complexed With The
           Bisubstrate Inhibitor Tp5a At 2.0 A Resolution:
           Implications For Catalysis And Azt Activation
           >gi|4558237|pdb|3TMK|H Chain H, Crystal Structure Of
           Yeast Thymidylate Kinase Complexed With The Bisubstrate
           Inhibitor Tp5a At 2.0 A Resolution: Implications For
           Catalysis And Azt Activation >gi|4558232|pdb|3TMK|C
           Chain C, Crystal Structure Of Yeast Thymidylate Kinase
           Complexed With The Bisubstrate Inhibitor Tp5a At 2.0 A
           Resolution: Implications For Catalysis And Azt
           Activation >gi|3318847|pdb|1TMK|A Chain A, Yeast
           Thymidylate Kinase Complexed With Thymidine
           Monophosphate (Dtmp) >gi|3318848|pdb|1TMK|B Chain B,
           Yeast Thymidylate Kinase Complexed With Thymidine
           Monophosphate (Dtmp) >gi|3318768|pdb|2TMK|A Chain A,
           Yeast Thymidylate Kinase Complexed With
           3'-Azido-3'-Deoxythymidine Monophosphate (Azt-Mp)
           >gi|3318769|pdb|2TMK|B Chain B, Yeast Thymidylate Kinase
           Complexed With 3'-Azido-3'-Deoxythymidine Monophosphate
           (Azt-Mp) >gi|172971|gb|AAB05644.1| (M15468) thymidylate
           kinase [Saccharomyces cerevisiae]
           >gi|1015725|emb|CAA89585.1| (Z49557) ORF YJR057w
           [Saccharomyces cerevisiae] >gi|1019679|gb|AAB39283.1|
           (L47993) ORF YJR057w [Saccharomyces cerevisiae]
           Length = 216
           
 Score = 79.6 bits (193), Expect = 3e-14
 Identities = 59/181 (32%), Positives = 97/181 (52%), Gaps = 14/181 (7%)

Query: 2   RGYFVVLEGIDGSGKTTQAKLLAEWFEEQGWDVLLTKEPTDTEFGRLIRELVLKNSIIDG 61
           RG  +++EG+D +GKTTQ  +L +  +      LL      T  G LI E +  +S    
Sbjct: 4   RGKLILIEGLDRTGKTTQCNILYKKLQPNC--KLLKFPERSTRIGGLINEYLTDDSF--- 58

Query: 62  SRISYEAEALLFAADRAEHVKKVILPALEKGKVVICDRYLYSSLAYQWAR---GLSLEWL 118
            ++S +A  LLF+A+R E V K+    LE GK ++ DRY+YS +AY  A+   G+ L+W 
Sbjct: 59  -QLSDQAIHLLFSANRWEIVDKIKKDLLE-GKNIVMDRYVYSGVAYSAAKGTNGMDLDWC 116

Query: 119 MQINSFAPRPDLAILLDLPVKESIRRTKARGNMSEFDKLLELQRKVRMNYLKLAEMFKEM 178
           +Q +    +PDL + L    ++     +  G   E  + ++ Q KV+  ++KL +  KE+
Sbjct: 117 LQPDVGLLKPDLTLFLS--TQDVDNNAEKSGFGDERYETVKFQEKVKQTFMKLLD--KEI 172

Query: 179 R 179
           R
Sbjct: 173 R 173


>gb|AAA35158.1| (K02116) thymidylate kinase [Saccharomyces cerevisiae]
           Length = 216
           
 Score = 79.6 bits (193), Expect = 3e-14
 Identities = 59/181 (32%), Positives = 97/181 (52%), Gaps = 14/181 (7%)

Query: 2   RGYFVVLEGIDGSGKTTQAKLLAEWFEEQGWDVLLTKEPTDTEFGRLIRELVLKNSIIDG 61
           RG  +++EG+D +GKTTQ  +L +  +      LL      T  G LI E +  +S    
Sbjct: 4   RGKLILIEGLDRTGKTTQCNILYKKLQPNC--KLLKFPERSTRIGGLINEYLTDDSF--- 58

Query: 62  SRISYEAEALLFAADRAEHVKKVILPALEKGKVVICDRYLYSSLAYQWAR---GLSLEWL 118
            ++S +A  LLF+A+R E V K+    LE GK ++ DRY+YS +AY  A+   G+ L+W 
Sbjct: 59  -QLSDQAIHLLFSANRWEIVDKIKKDLLE-GKNIVMDRYVYSGVAYSAAKGTNGMDLDWC 116

Query: 119 MQINSFAPRPDLAILLDLPVKESIRRTKARGNMSEFDKLLELQRKVRMNYLKLAEMFKEM 178
           +Q +    +PDL + L    ++     +  G   E  + ++ Q KV+  ++KL +  KE+
Sbjct: 117 LQPDVGLLKPDLTLFLS--TQDVDNNAEKSGFGDERYETVKFQEKVKQTFMKLLD--KEI 172

Query: 179 R 179
           R
Sbjct: 173 R 173


>gb|AAA34486.1| (K01783) CDC8 gene [Saccharomyces cerevisiae]
           Length = 216
           
 Score = 78.4 bits (190), Expect = 6e-14
 Identities = 58/181 (32%), Positives = 97/181 (53%), Gaps = 14/181 (7%)

Query: 2   RGYFVVLEGIDGSGKTTQAKLLAEWFEEQGWDVLLTKEPTDTEFGRLIRELVLKNSIIDG 61
           RG  +++EG+D +GKTTQ  +L +  +      LL      T  G LI E +  ++    
Sbjct: 4   RGKLILIEGLDRTGKTTQCNILYKKLQPNC--KLLKFPERSTRIGGLINEYLTDDTF--- 58

Query: 62  SRISYEAEALLFAADRAEHVKKVILPALEKGKVVICDRYLYSSLAYQWAR---GLSLEWL 118
            ++S +A  LLF+A+R E V K+    LE GK ++ DRY+YS +AY  A+   G+ L+W 
Sbjct: 59  -QLSDQAIHLLFSANRWEIVDKIKKDLLE-GKNIVMDRYVYSGVAYSAAKGTNGMDLDWC 116

Query: 119 MQINSFAPRPDLAILLDLPVKESIRRTKARGNMSEFDKLLELQRKVRMNYLKLAEMFKEM 178
           +Q +    +PDL + L    ++     +  G   E  + ++ Q KV+  ++KL +  KE+
Sbjct: 117 LQPDVGLLKPDLTLFLS--TQDVDNNAEKSGFGDERYETVKFQEKVKQTFMKLLD--KEI 172

Query: 179 R 179
           R
Sbjct: 173 R 173


>emb|CAB58191.1| (AJ270426) thymidylate kinase [Yersinia enterocolitica]
           >gi|6066872|emb|CAB58193.1| (AJ270428) thymidylate
           kinase [Yersinia enterocolitica]
           Length = 165
           
 Score = 78.4 bits (190), Expect = 6e-14
 Identities = 51/145 (35%), Positives = 78/145 (53%), Gaps = 7/145 (4%)

Query: 33  DVLLTKEPTDTEFGRLIRELVLKNSIIDGSRISYEAEALLFAADRAEHVKKVILPALEKG 92
           D++ T+EP  T     +R+L+ +   IDG  ++ +AE L+  A R + V+ VI PAL +G
Sbjct: 16  DIVFTREPGGTPLAEKLRDLIKQG--IDGEVLTDKAEVLMLYAARVQLVENVIKPALARG 73

Query: 93  KVVICDRYLYSSLAYQ-WARGLSLEWLMQINSFAP---RPDLAILLDLPVKESIRRTKAR 148
             V+ DR+  SS AYQ   RG+ +  +  +        RPDL + LDLP    + R +AR
Sbjct: 74  SWVVGDRHDLSSQAYQGGGRGIDINLMTSLRDTVLGEFRPDLTLYLDLPPVIGLARARAR 133

Query: 149 GNMSEFD-KLLELQRKVRMNYLKLA 172
           G +   + + L    + R  YLKLA
Sbjct: 134 GELDRIEQESLAFFERTRERYLKLA 158


>emb|CAB58204.1| (AJ270417) thymidylate kinase [Yersinia pestis]
           Length = 165
           
 Score = 77.3 bits (187), Expect = 1e-13
 Identities = 50/145 (34%), Positives = 78/145 (53%), Gaps = 7/145 (4%)

Query: 33  DVLLTKEPTDTEFGRLIRELVLKNSIIDGSRISYEAEALLFAADRAEHVKKVILPALEKG 92
           D++ T+EP  T     +R+L+ +   IDG  ++ +AE L+  A R + V+ VI PAL +G
Sbjct: 16  DIVFTREPGGTPLAEKLRDLIKQG--IDGEVLTDKAEVLMLYAARVQLVENVIKPALARG 73

Query: 93  KVVICDRYLYSSLAYQ-WARGLSLEWLMQINSFAP---RPDLAILLDLPVKESIRRTKAR 148
             V+ DR+  SS AYQ   RG+  + +  +        RPDL + LDLP    + R +AR
Sbjct: 74  SWVVGDRHDLSSQAYQGGGRGIDSQLMASLRDTVLGEFRPDLTLYLDLPPAVGLARARAR 133

Query: 149 GNMSEFD-KLLELQRKVRMNYLKLA 172
           G +   + + L    + R  YL+LA
Sbjct: 134 GELDRIEQESLAFFERTRARYLELA 158


>emb|CAB58225.1| (AJ270418) thymidylate kinase [Yersinia pseudotuberculosis]
           >gi|6066854|emb|CAB58210.1| (AJ270419) thymidylate
           kinase [Yersinia pseudotuberculosis]
           >gi|6066856|emb|CAB58211.1| (AJ270420) thymidylate
           kinase [Yersinia pseudotuberculosis]
           >gi|6066858|emb|CAB58212.1| (AJ270421) thymidylate
           kinase [Yersinia pseudotuberculosis]
           Length = 165
           
 Score = 77.3 bits (187), Expect = 1e-13
 Identities = 50/145 (34%), Positives = 78/145 (53%), Gaps = 7/145 (4%)

Query: 33  DVLLTKEPTDTEFGRLIRELVLKNSIIDGSRISYEAEALLFAADRAEHVKKVILPALEKG 92
           D++ T+EP  T     +R+L+ +   IDG  ++ +AE L+  A R + V+ VI PAL +G
Sbjct: 16  DIVFTREPGGTPLAEKLRDLIKQG--IDGEVLTDKAEVLMLYAARVQLVENVIKPALARG 73

Query: 93  KVVICDRYLYSSLAYQ-WARGLSLEWLMQINSFAP---RPDLAILLDLPVKESIRRTKAR 148
             V+ DR+  SS AYQ   RG+  + +  +        RPDL + LDLP    + R +AR
Sbjct: 74  SWVVGDRHDLSSQAYQGGGRGIDSQLMASLRDTVLGEFRPDLTLYLDLPPAVGLARARAR 133

Query: 149 GNMSEFD-KLLELQRKVRMNYLKLA 172
           G +   + + L    + R  YL+LA
Sbjct: 134 GELDRIEQESLAFFERTRARYLELA 158


>emb|CAB58213.1| (AJ270422) thymidylate kinase [Yersinia pseudotuberculosis]
           Length = 165
           
 Score = 77.3 bits (187), Expect = 1e-13
 Identities = 50/145 (34%), Positives = 78/145 (53%), Gaps = 7/145 (4%)

Query: 33  DVLLTKEPTDTEFGRLIRELVLKNSIIDGSRISYEAEALLFAADRAEHVKKVILPALEKG 92
           D++ T+EP  T     +R+L+ +   IDG  ++ +AE L+  A R + V+ VI PAL +G
Sbjct: 16  DIVFTREPGGTPLAEKLRDLIKQG--IDGEVLTDKAEVLMLYAARVQLVENVIKPALARG 73

Query: 93  KVVICDRYLYSSLAYQ-WARGLSLEWLMQINSFAP---RPDLAILLDLPVKESIRRTKAR 148
             V+ DR+  SS AYQ   RG+  + +  +        RPDL + LDLP    + R +AR
Sbjct: 74  SWVVGDRHDLSSQAYQGGGRGIDSQLMASLRDTVLGEFRPDLTLYLDLPPAVGLARARAR 133

Query: 149 GNMSEFD-KLLELQRKVRMNYLKLA 172
           G +   + + L    + R  YL+LA
Sbjct: 134 GELDRIEQESLAFFERTRARYLELA 158


>emb|CAB58188.1| (AJ270423) thymidylate kinase [Yersinia enterocolitica]
           >gi|6066864|emb|CAB58189.1| (AJ270424) thymidylate
           kinase [Yersinia enterocolitica]
           >gi|6066866|emb|CAB58190.1| (AJ270425) thymidylate
           kinase [Yersinia enterocolitica]
           Length = 165
           
 Score = 77.3 bits (187), Expect = 1e-13
 Identities = 50/145 (34%), Positives = 78/145 (53%), Gaps = 7/145 (4%)

Query: 33  DVLLTKEPTDTEFGRLIRELVLKNSIIDGSRISYEAEALLFAADRAEHVKKVILPALEKG 92
           D++ T+EP  T     +R+L+ +   IDG  ++ +AE L+  A R + V+ VI PAL +G
Sbjct: 16  DIVFTREPGGTPLAEKLRDLIKQG--IDGEVLTDKAEVLMLYAARVQLVENVIKPALARG 73

Query: 93  KVVICDRYLYSSLAYQ-WARGLSLEWLMQINSFAP---RPDLAILLDLPVKESIRRTKAR 148
             V+ DR+  SS AYQ   RG+ +  +  +        RPDL + LDLP    + R +AR
Sbjct: 74  SWVVGDRHDLSSQAYQGGGRGIDINLMTSLRDTVLGEFRPDLTLYLDLPPAIGLARARAR 133

Query: 149 GNMSEFD-KLLELQRKVRMNYLKLA 172
           G +   + + L    + R  YL+LA
Sbjct: 134 GELDRIEQESLAFFERTRERYLELA 158


>emb|CAB58192.1| (AJ270427) thymidylate kinase [Yersinia enterocolitica]
           >gi|6066874|emb|CAB58194.1| (AJ270429) thymidylate
           kinase [Yersinia enterocolitica]
           Length = 165
           
 Score = 76.9 bits (186), Expect = 2e-13
 Identities = 50/145 (34%), Positives = 78/145 (53%), Gaps = 7/145 (4%)

Query: 33  DVLLTKEPTDTEFGRLIRELVLKNSIIDGSRISYEAEALLFAADRAEHVKKVILPALEKG 92
           D++ T+EP  T     +R+L+ +   IDG  ++ +AE L+  A R + V+ VI PAL +G
Sbjct: 16  DIVFTREPGGTPLAEKLRDLIKQG--IDGEVLTDKAEVLMLYAARVQLVENVIKPALARG 73

Query: 93  KVVICDRYLYSSLAYQ-WARGLSLEWLMQINSFAP---RPDLAILLDLPVKESIRRTKAR 148
             V+ DR+  SS AYQ   RG+ +  +  +        RPDL + LDLP    + R +AR
Sbjct: 74  SWVVGDRHDLSSQAYQGGGRGIDINLMTSLRDTVLGEFRPDLTLYLDLPPVIGLARARAR 133

Query: 149 GNMSEFD-KLLELQRKVRMNYLKLA 172
           G +   + + L    + R  YL+LA
Sbjct: 134 GELDRIEQESLAFFERTRERYLELA 158


>pir||F81347 probable dTMP kinase (EC 2.7.4.9) Cj0766c [imported] -
           Campylobacter jejuni (strain NCTC 11168)
           >gi|6968212|emb|CAB73031.1| (AL139076) putative
           thymidylate kinase [Campylobacter jejuni]
           Length = 192
           
 Score = 76.5 bits (185), Expect = 2e-13
 Identities = 65/203 (32%), Positives = 104/203 (51%), Gaps = 30/203 (14%)

Query: 5   FVVLEGIDGSGKTTQAKLLAEWFEEQGWDVLLTKEPTDTEFGRLIRELVLKNSIIDGSRI 64
           +VV EGID  GK+TQ  LL E ++    D + T EP  TE G+ +RE++L  +      I
Sbjct: 2   YVVFEGIDCVGKSTQISLLKEIYK----DAIFTLEPGGTELGKHLREILLNKT----HPI 53

Query: 65  SYEAEALLFAADRAEHVKKVILPALEKGKVVICDRYLYSSLAYQWARGLSLEWLMQINSF 124
           +  AE LLF ADRA+H ++++     + K++I DR   S +AY  A+    + L  +NSF
Sbjct: 54  NKRAELLLFLADRAQHFEEIL--KTNQNKLIISDRSFISGMAY--AKDFENDLLFALNSF 109

Query: 125 APR---PDLAILLDLPVKESIRRTKARGNMSEFDKL--------LELQRKVR--MNYLKL 171
           A     P   I L    K      + R +  E D +        L +Q K+   +++LK 
Sbjct: 110 ALENFFPQKIIFL----KGDANLIQERLSQKELDSIEKRGIEYFLSVQDKLEKVLHFLK- 164

Query: 172 AEMFKEMRIVNAMASVEEVHEDI 194
            ++  E+  ++A  S E++H+ I
Sbjct: 165 EKISVEILTLDAKESKEKLHQQI 187


>sp|Q22018|KTHY_CAEEL PROBABLE THYMIDYLATE KINASE (DTMP KINASE) >gi|7506780|pir||T24244
           hypothetical protein R53.2 - Caenorhabditis elegans
           >gi|3879168|emb|CAA91347.1| (Z66515) contains similarity
           to Pfam domain: PF02223 (Thymidylate kinase),
           Score=250.1, E-value=1e-71, N=1~cDNA EST EMBL:T00891
           comes from this gene~cDNA EST yk115f8.3 comes from this
           gene~cDNA EST EMBL:D73052 comes from this gene~cDNA EST
           yk115f8.5 co>
           Length = 218
           
 Score = 76.1 bits (184), Expect = 3e-13
 Identities = 50/153 (32%), Positives = 77/153 (49%), Gaps = 16/153 (10%)

Query: 2   RGYFVVLEGIDGSGKTTQAKLLAEWFEEQGWD----------VLLTKEPTDTEFGRLIRE 51
           RG  +V EG+D SGK+TQAK L E   ++  +          VL       +  G+LI +
Sbjct: 7   RGLLIVFEGLDRSGKSTQAKRLVESINKKSTESGDASSSPSAVLQAFPDRSSSIGKLIDQ 66

Query: 52  LVLKNSIIDGSRISYEAEALLFAADRAEHVKKVILPALEKGKVVICDRYLYSSLAYQWAR 111
            + K   +D   +      LLF+ADR     ++I   + KG  VICDRY YS +AY  A+
Sbjct: 67  YLRKEIDMDEHALH-----LLFSADRFSK-NQMIRDNIAKGIDVICDRYCYSGVAYSLAK 120

Query: 112 GLSLEWLMQINSFAPRPDLAILLDLPVKESIRR 144
           GL  +W+   +   P+PD  +  D+  + + +R
Sbjct: 121 GLPEQWVRSSDVGLPKPDAVLFFDVSPEVAAQR 153


>emb|CAC11229.1| (AL445063) conserved hypothetical protein [Thermoplasma
           acidophilum]
           Length = 193
           
 Score = 74.1 bits (179), Expect = 1e-12
 Identities = 63/211 (29%), Positives = 104/211 (48%), Gaps = 35/211 (16%)

Query: 5   FVVLEGIDGSGKTTQAKLLAEWFEEQGWDVLLTKEPTDTEFGRLIRELVLKNSIIDGSRI 64
           F+ +EGIDG+GKTT A+ +      +G+ V +TKEPTD           ++N   DG  +
Sbjct: 2   FIAIEGIDGAGKTTLARGIGNMLLGEGYRVYMTKEPTDG----------MENYAGDGVEL 51

Query: 65  SYEAEALLFAADRAEHVKKVILPALEKGKVVICDRYLYSSLAYQWARGL---------SL 115
                 L F  +R  H ++ I   ++ G++VICDRY+ SS AYQ+  G+         + 
Sbjct: 52  -----FLKFTINRYAH-QREIDRHIKNGEIVICDRYIRSSYAYQF-EGIAEFFGNSEKAW 104

Query: 116 EWLMQINSFAP-RPDLAILLDLPVKESIRRTKARGNMSEFDKLLELQRKVRMNYLKLAEM 174
           EW+  ++     RPD+ I +D+  + ++ R   RG  +   +  +  R VR  Y    + 
Sbjct: 105 EWMDSVSEIIKIRPDVQIYVDVDEETAMERISRRGLRNPHFENEQKLRSVRQIY----KG 160

Query: 175 FKEMRIVNA----MASVEEVHEDIVALVKHE 201
           F+   IV+      A + E  E I+A ++ E
Sbjct: 161 FQWDLIVDGGRDKEAIISETFEKIIARLRQE 191


>sp|P36590|KTHY_SCHPO THYMIDYLATE KINASE (DTMP KINASE) >gi|478751|pir||S28955 dTMP kinase
           (EC 2.7.4.9) - fission yeast  (Schizosaccharomyces
           pombe) >gi|4974|emb|CAA46698.1| (X65868) thymidylate
           kinase [Schizosaccharomyces pombe]
           Length = 210
           
 Score = 73.4 bits (177), Expect = 2e-12
 Identities = 64/205 (31%), Positives = 103/205 (50%), Gaps = 16/205 (7%)

Query: 2   RGYFVVLEGIDGSGKTTQAKLLAEWFEEQGWDVLLTKEPT-DTEFGRLIRELVLKNSIID 60
           RG  +V+EG+D SGK+TQ +LL +        + L K P   T  G+ I + + ++  ++
Sbjct: 6   RGRLIVIEGLDRSGKSTQCQLLVDKLILNMKRLKLFKFPDRTTAIGKKIDDYLTESVQLN 65

Query: 61  GSRISYEAEALLFAADRAEHVKKVILPALEKGKVVICDRYLYSSLAYQWARGLSLEWLMQ 120
              I      LLF+A+R E    +   A ++    I DRY +S +A+  A+GL  EW   
Sbjct: 66  DQVIH-----LLFSANRWE--PSIYYRANQQRCNCILDRYAFSGIAFSAAKGLDWEWCKS 118

Query: 121 INSFAPRPDLAILLDLPVKESIRRTKARGNMSEFDKLLELQRKVRMNYLKLAEMFKE--M 178
            +    RPDL I L+  V   I  T+ +     ++K +E+Q KV  N  +L + F+E  +
Sbjct: 119 PDRGLTRPDLVIFLN--VDPRIAATRGQYGEERYEK-IEMQEKVLKNLQRLQKEFREEGL 175

Query: 179 RIVNAMAS---VEEVHEDIVALVKH 200
             +   AS   +E+V   IV LV +
Sbjct: 176 EFITLDASSYALEDVDSQIVDLVSN 200


>sp|P97930|KTHY_MOUSE THYMIDYLATE KINASE (DTMP KINASE) >gi|1836042|gb|AAB46838.1|
           (S82853) thymidylate kinase, TMK=catalyzes theconvertion
           of dTMP to dTDP [mice, BALB/c, 3T3 cells, Peptide, 227
           aa] [Mus sp.]
           Length = 227
           
 Score = 71.0 bits (171), Expect = 1e-11
 Identities = 48/145 (33%), Positives = 76/145 (52%), Gaps = 8/145 (5%)

Query: 2   RGYFVVLEGIDGSGKTTQAKLLAEWFEEQGWDVLLTKEP-TDTEFGRLIRELVLKNSIID 60
           RG  +VLEG+D +GKTTQ   L       G    L + P   TE G+L+   + K + ++
Sbjct: 5   RGALIVLEGVDRAGKTTQGLKLVTALCASGHRAELLRFPERSTEIGKLLNSYLEKKTELE 64

Query: 61  GSRISYEAEALLFAADRAEHVKKVILPALEKGKVVICDRYLYSSLAYQWAR-GLSLEWLM 119
              +      LLF+A+R E V  +I   L +G  ++ DRY +S +A+  A+   SL+W  
Sbjct: 65  DHSVH-----LLFSANRWEQV-PLIKAKLNQGVTLVLDRYAFSGVAFTGAKENFSLDWCK 118

Query: 120 QINSFAPRPDLAILLDLPVKESIRR 144
           Q +   P+PDL + L L + ++  R
Sbjct: 119 QPDVGLPKPDLILFLQLQLLDAAAR 143


>pir||S48605 hypothetical protein - Mycoplasma capricolum (fragment)
          >gi|950071|emb|CAA83746.1| (Z33079) ATP-bind.
          pyrimidine kinase [Mycoplasma capricolum]
          Length = 98
          
 Score = 69.1 bits (166), Expect = 4e-11
 Identities = 40/93 (43%), Positives = 54/93 (58%), Gaps = 5/93 (5%)

Query: 5  FVVLEGIDGSGKTTQAKLLAEWFEEQGWDVLLTKEPTDTEFGRLIRELVLKNSIIDGSRI 64
          F+  EG+DGSGKTT    + E  E   + VL+T+EP        IR+++L N   D   +
Sbjct: 2  FITFEGMDGSGKTTALLKVKEELERLNYKVLITREPGGEVIAEQIRQIILDNKNKD---M 58

Query: 65 SYEAEALLFAADRAEHVKKVILPALEKGKVVIC 97
              EALLF A R +H++KVI PALEK   +IC
Sbjct: 59 DAWTEALLFIASRNQHLQKVIKPALEKN--IIC 89


>pir||H70198 thymidylate kinase (tmk) homolog - Lyme disease spirochete
           >gi|2688733|gb|AAC67140.1| (AE001178) thymidylate kinase
           (tmk) [Borrelia burgdorferi]
           Length = 257
           
 Score = 67.9 bits (163), Expect = 8e-11
 Identities = 54/193 (27%), Positives = 100/193 (50%), Gaps = 21/193 (10%)

Query: 5   FVVLEGIDGSGKTTQAKLLAEWFEEQGWDVLLTKEPTDTEFGRLIRELVLK-NSIIDGSR 63
           F  +EGIDGSGKT+    L     ++      TKEP+    G +IR+ ++   + ++ S 
Sbjct: 63  FYCIEGIDGSGKTSITNKLKALCNDES-RYYFTKEPSSGIIGEMIRKQLMNFENPLEEST 121

Query: 64  ISYEAEALLFAADRAEHVKKV--ILPALE-KGKVVICDRYLYSSLAYQWARGLSLEWLMQ 120
            +Y     L+AADR +H+ K   IL  L  K + +I DRYL+SS+AYQ   G       +
Sbjct: 122 FAY-----LYAADRHDHLYKKGGILEILNTKSRKIITDRYLFSSIAYQGKLG------YE 170

Query: 121 INSFAPRPDLAILLDLP---VKESIRRTKARGNMSEFDKLLELQRKVRMNYLKL-AEMFK 176
           +N   P P+    ++       E I++ + + ++ E +K    + ++ + YLK+  ++ K
Sbjct: 171 LNKNFPLPEKVFFIETDPNIAYERIQKNRTQSDLFELEKYKTFE-QIALKYLKIFKKLEK 229

Query: 177 EMRIVNAMASVEE 189
           ++ ++    S+++
Sbjct: 230 KINVIYINNSIKD 242


  Database: ./suso.pep
    Posted date:  Jul 6, 2001  5:57 PM
  Number of letters in database: 840,471
  Number of sequences in database:  2977
  
  Database: /banques/blast2/nr.pep
    Posted date:  Dec 14, 2000 12:46 PM
  Number of letters in database: 188,266,275
  Number of sequences in database:  595,510
  
Lambda     K      H
   0.321    0.138    0.392 

Gapped
Lambda     K      H
   0.270   0.0470    0.230 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 69917478
Number of Sequences: 2977
Number of extensions: 2622098
Number of successful extensions: 10655
Number of sequences better than 1.0e-10: 62
Number of HSP's better than  0.0 without gapping: 3
Number of HSP's successfully gapped in prelim test: 59
Number of HSP's that attempted gapping in prelim test: 10527
Number of HSP's gapped (non-prelim): 62
length of query: 205
length of database: 189,106,746
effective HSP length: 55
effective length of query: 150
effective length of database: 156,189,961
effective search space: 23428494150
effective search space used: 23428494150
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 41 (21.8 bits)
S2: 163 (67.9 bits)