BLASTP 2.0.10 [Aug-26-1999]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= PAB0319 (tmk-like) DE:thymidylate kinase related (tmk)
(205 letters)
Database: ./suso.pep; /banques/blast2/nr.pep
598,487 sequences; 189,106,746 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
pir||A75165 thymidylate kinase related (tmk) PAB0319 - Pyrococcu... 406 e-112
sp|O59366|KTHY_PYRHO PROBABLE THYMIDYLATE KINASE (DTMP KINASE) >... 350 6e-96
sp|Q57741|KTHY_METJA PROBABLE THYMIDYLATE KINASE (DTMP KINASE) >... 133 2e-30
sp|O67099|KTHY_AQUAE THYMIDYLATE KINASE (DTMP KINASE) >gi|743464... 132 3e-30
gi|11497681 thymidylate kinase (tmk) [Archaeoglobus fulgidus] >g... 131 5e-30
pir||T36663 protein kinase, transmembrane - Streptomyces coelico... 129 3e-29
pir||F82788 thymidylate kinase XF0580 [imported] - Xylella fasti... 121 7e-27
gb|AAK41077.1| Thymidylate kinase (tmK-1) [Sulfolobus solfataricus] 119 2e-26
sp|Q9UXG7|KTHY_SULSO PROBABLE THYMIDYLATE KINASE (DTMP KINASE) >... 119 2e-26
dbj|BAB03761.1| (AP001507) thymidylate kinase [Bacillus halodurans] 118 6e-26
pir||H71333 probable thymidylate kinase (tmk) - syphilis spiroch... 117 1e-25
sp|Q9X0I3|KTHY_THEMA THYMIDYLATE KINASE (DTMP KINASE) >gi|743464... 115 5e-25
pir||D75560 thymidylate kinase - Deinococcus radiodurans (strain... 115 5e-25
pir||E83275 thymidylate kinase PA2962 [imported] - Pseudomonas a... 113 1e-24
pir||G81700 thymidylate kinase TC0460 [imported] - Chlamydia mur... 110 1e-23
sp|P37537|KTHY_BACSU THYMIDYLATE KINASE (DTMP KINASE) >gi|212702... 109 2e-23
sp|O26009|KTHY_HELPY THYMIDYLATE KINASE (DTMP KINASE) >gi|743464... 109 2e-23
sp|O27793|KTHY_METTH PROBABLE THYMIDYLATE KINASE (DTMP KINASE) >... 108 4e-23
sp|P37345|KTHY_ECOLI THYMIDYLATE KINASE (DTMP KINASE) >gi|214553... 107 9e-23
sp|Q9RQJ9|KTHY_CAUCR THYMIDYLATE KINASE (DTMP KINASE) >gi|631831... 106 2e-22
pdb|4TMK|A Chain A, Complex Of E. Coli Thymidylate Kinase With T... 106 2e-22
gb|AAA93511.1| (L37441) thymidine:thymidylate kinase:zeocin resi... 105 4e-22
gb|AAA93513.1| (L37442) thymidylate:zeocin resistance protein:ND... 105 4e-22
pir||H81932 probable dTMP kinase (EC 2.7.4.9) NMA0869 [imported]... 105 4e-22
pir||B81173 thymidylate kinase NMB0670 [imported] - Neisseria me... 104 8e-22
sp|Q9ZJE5|KTHY_HELPJ THYMIDYLATE KINASE (DTMP KINASE) >gi|743464... 104 1e-21
sp|O69169|KTHY_YERPE THYMIDYLATE KINASE (DTMP KINASE) >gi|317688... 102 2e-21
pir||S76121 hypothetical protein - Synechocystis sp. (strain PCC... 101 5e-21
sp|Q55593|KTHY_SYNY3 THYMIDYLATE KINASE (DTMP KINASE) 101 5e-21
sp|P47252|KTHY_MYCGE THYMIDYLATE KINASE (DTMP KINASE) >gi|136186... 101 9e-21
sp|O84191|KTHY_CHLTR THYMIDYLATE KINASE (DTMP KINASE) >gi|743465... 99 5e-20
pir||T41553 thymidylate kinase - fission yeast (Schizosaccharomy... 98 6e-20
sp|Q9Z8R5|KTHY_CHLPN THYMIDYLATE KINASE (DTMP KINASE) >gi|743465... 98 8e-20
pir||A64153 dTMP kinase (EC 2.7.4.9) - Haemophilus influenzae (s... 96 2e-19
sp|P44719|KTHY_HAEIN THYMIDYLATE KINASE (DTMP KINASE) >gi|157343... 96 2e-19
sp|Q9YA48|KTHY_AERPE PROBABLE THYMIDYLATE KINASE (DTMP KINASE) >... 96 2e-19
pir||A82128 thymidylate kinase VC2016 [imported] - Vibrio choler... 95 5e-19
sp|Q9ZCN9|KTHY_RICPR THYMIDYLATE KINASE (DTMP KINASE) >gi|743465... 95 7e-19
gb|AAK41441.1| Thymidylate kinase (tmK-2) [Sulfolobus solfatari... 91 1e-17
pir||H82944 thymidylate kinase UU020 [imported] - Ureaplasma ure... 90 2e-17
sp|P75106|KTHY_MYCPN THYMIDYLATE KINASE (DTMP KINASE) >gi|214666... 87 2e-16
gb|AAA21719.1| (L16991) thymidylate kinase [Homo sapiens] 86 3e-16
gi|6912340 deoxythymidylate kinase (thymidylate kinase) [Homo sa... 83 2e-15
sp|P23919|KTHY_HUMAN THYMIDYLATE KINASE (DTMP KINASE) 83 2e-15
gb|AAG20116.1| (AE005090) thymidylate kinase; Tmk [Halobacterium... 83 2e-15
sp|P57434|KTHY_BUCAI THYMIDYLATE KINASE (DTMP KINASE) >gi|100390... 82 5e-15
gi|6322517 thymidylate kinase; Cdc8p [Saccharomyces cerevisiae] ... 80 3e-14
gb|AAA35158.1| (K02116) thymidylate kinase [Saccharomyces cerevi... 80 3e-14
gb|AAA34486.1| (K01783) CDC8 gene [Saccharomyces cerevisiae] 78 6e-14
emb|CAB58191.1| (AJ270426) thymidylate kinase [Yersinia enteroco... 78 6e-14
emb|CAB58204.1| (AJ270417) thymidylate kinase [Yersinia pestis] 77 1e-13
emb|CAB58225.1| (AJ270418) thymidylate kinase [Yersinia pseudotu... 77 1e-13
emb|CAB58213.1| (AJ270422) thymidylate kinase [Yersinia pseudotu... 77 1e-13
emb|CAB58188.1| (AJ270423) thymidylate kinase [Yersinia enteroco... 77 1e-13
emb|CAB58192.1| (AJ270427) thymidylate kinase [Yersinia enteroco... 77 2e-13
pir||F81347 probable dTMP kinase (EC 2.7.4.9) Cj0766c [imported]... 76 2e-13
sp|Q22018|KTHY_CAEEL PROBABLE THYMIDYLATE KINASE (DTMP KINASE) >... 76 3e-13
emb|CAC11229.1| (AL445063) conserved hypothetical protein [Therm... 74 1e-12
sp|P36590|KTHY_SCHPO THYMIDYLATE KINASE (DTMP KINASE) >gi|478751... 73 2e-12
sp|P97930|KTHY_MOUSE THYMIDYLATE KINASE (DTMP KINASE) >gi|183604... 71 1e-11
pir||S48605 hypothetical protein - Mycoplasma capricolum (fragme... 69 4e-11
pir||H70198 thymidylate kinase (tmk) homolog - Lyme disease spir... 68 8e-11
>pir||A75165 thymidylate kinase related (tmk) PAB0319 - Pyrococcus abyssi
(strain Orsay) >gi|5457910|emb|CAB49400.1| (AJ248284)
thymidylate kinase related (tmk) [Pyrococcus abyssi]
Length = 205
Score = 406 bits (1032), Expect = e-112
Identities = 205/205 (100%), Positives = 205/205 (100%)
Query: 1 MRGYFVVLEGIDGSGKTTQAKLLAEWFEEQGWDVLLTKEPTDTEFGRLIRELVLKNSIID 60
MRGYFVVLEGIDGSGKTTQAKLLAEWFEEQGWDVLLTKEPTDTEFGRLIRELVLKNSIID
Sbjct: 1 MRGYFVVLEGIDGSGKTTQAKLLAEWFEEQGWDVLLTKEPTDTEFGRLIRELVLKNSIID 60
Query: 61 GSRISYEAEALLFAADRAEHVKKVILPALEKGKVVICDRYLYSSLAYQWARGLSLEWLMQ 120
GSRISYEAEALLFAADRAEHVKKVILPALEKGKVVICDRYLYSSLAYQWARGLSLEWLMQ
Sbjct: 61 GSRISYEAEALLFAADRAEHVKKVILPALEKGKVVICDRYLYSSLAYQWARGLSLEWLMQ 120
Query: 121 INSFAPRPDLAILLDLPVKESIRRTKARGNMSEFDKLLELQRKVRMNYLKLAEMFKEMRI 180
INSFAPRPDLAILLDLPVKESIRRTKARGNMSEFDKLLELQRKVRMNYLKLAEMFKEMRI
Sbjct: 121 INSFAPRPDLAILLDLPVKESIRRTKARGNMSEFDKLLELQRKVRMNYLKLAEMFKEMRI 180
Query: 181 VNAMASVEEVHEDIVALVKHELLGL 205
VNAMASVEEVHEDIVALVKHELLGL
Sbjct: 181 VNAMASVEEVHEDIVALVKHELLGL 205
>sp|O59366|KTHY_PYRHO PROBABLE THYMIDYLATE KINASE (DTMP KINASE) >gi|7434646|pir||A71177
probable thymidylate kinase - Pyrococcus horikoshii
>gi|3258125|dbj|BAA30808.1| (AP000007) 205aa long
hypothetical thymidylate kinase [Pyrococcus horikoshii]
Length = 205
Score = 350 bits (889), Expect = 6e-96
Identities = 166/205 (80%), Positives = 192/205 (92%)
Query: 1 MRGYFVVLEGIDGSGKTTQAKLLAEWFEEQGWDVLLTKEPTDTEFGRLIRELVLKNSIID 60
MRGYF+VLEGIDGSGKTTQAKLLAEWFE++G++VLLTKEPTD+E G+LIR ++L+ S+ID
Sbjct: 1 MRGYFIVLEGIDGSGKTTQAKLLAEWFEDKGYEVLLTKEPTDSELGKLIRRIILEESVID 60
Query: 61 GSRISYEAEALLFAADRAEHVKKVILPALEKGKVVICDRYLYSSLAYQWARGLSLEWLMQ 120
GS+ISYEAEALLFAADRAEHVKK+ILPAL +GKVVICDRY YSSLAYQWARGL L WL+Q
Sbjct: 61 GSKISYEAEALLFAADRAEHVKKIILPALSEGKVVICDRYFYSSLAYQWARGLDLNWLIQ 120
Query: 121 INSFAPRPDLAILLDLPVKESIRRTKARGNMSEFDKLLELQRKVRMNYLKLAEMFKEMRI 180
+NSFAPRPDLAILLDLPVKES+RR K RG ++EFDK++ELQRKVR NYLKLAEMF EMRI
Sbjct: 121 VNSFAPRPDLAILLDLPVKESLRRIKLRGTLTEFDKIVELQRKVRHNYLKLAEMFPEMRI 180
Query: 181 VNAMASVEEVHEDIVALVKHELLGL 205
VNA++S+E++H DIVALVKHELLGL
Sbjct: 181 VNALSSIEDIHSDIVALVKHELLGL 205
>sp|Q57741|KTHY_METJA PROBABLE THYMIDYLATE KINASE (DTMP KINASE) >gi|2127876|pir||F64336
dTMP kinase (EC 2.7.4.9) - Methanococcus jannaschii
>gi|1591015|gb|AAB98278.1| (U67484) thymidylate kinase
(tmk) [Methanococcus jannaschii]
Length = 188
Score = 133 bits (331), Expect = 2e-30
Identities = 80/196 (40%), Positives = 121/196 (60%), Gaps = 16/196 (8%)
Query: 5 FVVLEGIDGSGKTTQAKLLAEWFEEQGWDVLLTKEPTDTEFGRLIRELVLKNSIIDGSRI 64
F+V EGIDGSGKTTQ+KLLA+ D T EP+++ G++IRE++ + +D +
Sbjct: 6 FIVFEGIDGSGKTTQSKLLAKKM-----DAFWTYEPSNSLVGKIIREILSGKTEVDNKTL 60
Query: 65 SYEAEALLFAADRAEHVKKVILPALEKGKVVICDRYLYSSLAYQWARGLSLEWLMQINSF 124
ALLFAADR EH K +I L+K + V+CDRYLYSS+AYQ G+ ++ IN +
Sbjct: 61 -----ALLFAADRIEHTK-LIKEELKK-RDVVCDRYLYSSIAYQSVAGVDENFIKSINRY 113
Query: 125 APRPDLAILLDLPVKESIRRTKARGNMSEFDKLLELQRKVRMNYLKLAEMFKEMRIVNAM 184
A +PD+ LL + ++ +++R K + + D L +KV+ YL+LAE + + I
Sbjct: 114 ALKPDIVFLLIVDIETALKRVKTKDIFEKKDFL----KKVQDKYLELAEEYNFIVIDTTK 169
Query: 185 ASVEEVHEDIVALVKH 200
SVEEVH +I+ +K+
Sbjct: 170 KSVEEVHNEIIGYLKN 185
>sp|O67099|KTHY_AQUAE THYMIDYLATE KINASE (DTMP KINASE) >gi|7434642|pir||H70383
thymidylate kinase - Aquifex aeolicus
>gi|2983484|gb|AAC07063.1| (AE000716) thymidylate kinase
[Aquifex aeolicus]
Length = 195
Score = 132 bits (329), Expect = 3e-30
Identities = 76/194 (39%), Positives = 126/194 (64%), Gaps = 14/194 (7%)
Query: 6 VVLEGIDGSGKTTQAKLLAEWFEEQGWDVLLTKEPTDTEFGRLIRELVLKNSIIDGSRIS 65
+ EGIDGSGKTTQAK L E+ +++G+ V L +EP T+ G ++RE++L + +
Sbjct: 3 IAFEGIDGSGKTTQAKKLYEYLKQKGYFVSLYREPGGTKVGEVLREILLTEELDE----- 57
Query: 66 YEAEALLFAADRAEHVKKVILPALEKGKVVICDRYLYSSLAYQ-WARGLSLEWLMQINSF 124
E LLF A R++ +++ I+P L++ KVVI DR++ S++AYQ + +GL +E++ +N F
Sbjct: 58 -RTELLLFEASRSKLIEEKIIPDLKRDKVVILDRFVLSTIAYQGYGKGLDVEFIKNLNEF 116
Query: 125 APR---PDLAILLDLPVKESIRRTKARGNMSEFDKLLELQRKVRMNYLKLAEMFKEMRIV 181
A R PD+ +LLD+PV ++RR K + N E + LE KVR +L+LA+ + + ++
Sbjct: 117 ATRGVKPDITLLLDIPVDIALRRLKEK-NRFENKEFLE---KVRKGFLELAKEEENVVVI 172
Query: 182 NAMASVEEVHEDIV 195
+A EEV ++I+
Sbjct: 173 DASGEEEEVFKEIL 186
>gi|11497681 thymidylate kinase (tmk) [Archaeoglobus fulgidus]
>gi|6016458|sp|O30175|KTHY_ARCFU PROBABLE THYMIDYLATE
KINASE (DTMP KINASE) >gi|7434641|pir||E69257 thymidylate
kinase (tmk) homolog - Archaeoglobus fulgidus
>gi|2650584|gb|AAB91163.1| (AE001102) thymidylate kinase
(tmk) [Archaeoglobus fulgidus]
Length = 196
Score = 131 bits (327), Expect = 5e-30
Identities = 76/195 (38%), Positives = 121/195 (61%), Gaps = 12/195 (6%)
Query: 6 VVLEGIDGSGKTTQAKLLAEWFEEQGWDVLLTKEPTDTEFGRLIRELVLKNSIIDGSRIS 65
+ +EGIDG+GKTT A +AE +E+G+ V + KEP D++FG+ I+ R+S
Sbjct: 3 IAVEGIDGAGKTTIAAYIAELLKEKGYKVKVLKEPGDSKFGKKIKS--------SEERLS 54
Query: 66 YEAEALLFAADRAEHVKKVILPALEKGKVVICDRYLYSSLAYQWARGLSLEWLMQIN-SF 124
E E LF DR ++ ILPAL+ G V+ DRY +S++AYQ ARG+ + ++N
Sbjct: 55 PEEELELFLKDREIDARENILPALQSGYAVVMDRYYFSNIAYQSARGIDARLIREMNEKI 114
Query: 125 APRPDLAILLDLPVKESIRRTKARGNMSEFDKLLELQRKVRMNYLKLAEMFKEMRIVNAM 184
AP+PDL ILLD+ + ++ R + RG +S F+K L+ RKVR +L+ A+ + +V+A
Sbjct: 115 APKPDLTILLDVEPEIALERVRKRGKLSPFEK-LDYLRKVRKCFLENAD--ETTVVVDAS 171
Query: 185 ASVEEVHEDIVALVK 199
+EEV E++ +++
Sbjct: 172 KPLEEVKEEVRKVIE 186
>pir||T36663 protein kinase, transmembrane - Streptomyces coelicolor
>gi|4539560|emb|CAB38479.1| (AL035636) integral membrane
protein with kinase activity [Streptomyces coelicolor
A3(2)]
Length = 1089
Score = 129 bits (321), Expect = 3e-29
Identities = 83/205 (40%), Positives = 121/205 (58%), Gaps = 13/205 (6%)
Query: 3 GYFVVLEGIDGSGKTTQAKLLAEWFEEQGWDVLLTKEPTDTEFGRLIRELVLKNSIIDGS 62
G+F+ LEG DG+GK+TQA+ LAEW +G +V+LT+EP T G+ +R ++L + +
Sbjct: 509 GFFIALEGGDGAGKSTQAEALAEWIRGKGHEVVLTREPGATPVGKRLRSILLD---VSSA 565
Query: 63 RISYEAEALLFAADRAEHVKKVILPALEKGKVVICDRYLYSSLAYQWA-RGLSLEWLMQI 121
+S+ AEALL+AADRAEHV V+ PALE+G VV+ DRY+ SS+AYQ A R LS + +I
Sbjct: 566 GLSHRAEALLYAADRAEHVDTVVRPALERGAVVVSDRYIDSSVAYQGAGRDLSPTEIARI 625
Query: 122 NSFAPR---PDLAILLDL-PVKESIRRTKARGNMSEFDKLLELQRKVRMNYLKLAEMFKE 177
N +A P L +LLD+ P R T+A + + E +VR +L LA
Sbjct: 626 NRWATNGLVPHLTVLLDVAPEAARERFTEAPDRLE--SEPAEFHARVRSGFLTLAAADPG 683
Query: 178 MRIVNAMASVEEVHEDIVALVKHEL 202
+V + E + +V+H L
Sbjct: 684 RYLV---VDAGQEPEAVTTVVRHRL 705
>pir||F82788 thymidylate kinase XF0580 [imported] - Xylella fastidiosa (strain
9a5c) >gi|9105444|gb|AAF83390.1|AE003904_11 (AE003904)
thymidylate kinase [Xylella fastidiosa]
Length = 217
Score = 121 bits (300), Expect = 7e-27
Identities = 74/200 (37%), Positives = 112/200 (56%), Gaps = 8/200 (4%)
Query: 3 GYFVVLEGIDGSGKTTQAKLLAEWFEEQGWDVLLTKEPTDTEFGRLIRELVLKNSIIDGS 62
G V +EGIDG+GKTT A+ LA G + +++KEPT+ +G L+R+
Sbjct: 9 GMLVAIEGIDGAGKTTLARSLALKLRGVGLETVVSKEPTNGPWGMLLRQSAATG------ 62
Query: 63 RISYEAEALLFAADRAEHVKKVILPALEKGKVVICDRYLYSSLAYQWARGLSLEWLMQIN 122
R S E E + DR +HV+ +I+P + +G VVI DRY S +AYQ A GL ++ L++ N
Sbjct: 63 RFSPEEEVDVLLRDRRQHVEDLIVPMIGRGAVVILDRYFPSMVAYQGAAGLPVDALLEAN 122
Query: 123 SFAPRPDLAILLDLPVKESIRRTKARGNMSEFDKLLELQRKVRMNYLKLAEMFKEMRIVN 182
+FAPRPD+ +LLD+P ++R RG+ + E + R +L L R+++
Sbjct: 123 AFAPRPDVLLLLDVPPAIGLQRIWERGSTPNHFETTENLSRCRDIFLALE--LPSKRVID 180
Query: 183 AMASVEEVHEDIVALVKHEL 202
A A+ E V +ALV L
Sbjct: 181 ATANAETVLSAALALVMEVL 200
>gb|AAK41077.1| Thymidylate kinase (tmK-1) [Sulfolobus solfataricus]
Length = 189
Score = 119 bits (296), Expect = 2e-26
Identities = 73/198 (36%), Positives = 115/198 (57%), Gaps = 15/198 (7%)
Query: 6 VVLEGIDGSGKTTQAKLLAEWFEEQ-GWDVLLTKEPTDTEFGRLIRELVLKNSIIDGSRI 64
+ +EGIDGSGKTT A LL E E + +V++T+EP + +LI ++ + I+
Sbjct: 5 IAIEGIDGSGKTTLANLLKEHLESKMKLNVIVTREPFSEDIIKLIEKIGWNDPIL----- 59
Query: 65 SYEAEALLFAADRAEHVKKVILPALEKGKVVICDRYLYSSLAYQWARGLSLEWLMQINSF 124
LLFAADR HV L ++ ++I DRY +SS+AYQ A G+ +W+ +NS+
Sbjct: 60 ----LVLLFAADREIHVNW--LSKIKDADLIILDRYYFSSIAYQGALGVDEQWIKMVNSY 113
Query: 125 APRPDLAILLDLPVKESIRRTKARGNMSEFDKLLELQRKVRMNYLKLAEMFKEMRIVNAM 184
P+PD+ ILLDLP++ +I R K + F++ ++ KVR YLKLA+ + +V+A
Sbjct: 114 FPKPDMVILLDLPIEVAISRIK--NDKFNFEEKIKSLAKVREKYLKLAKEY-NFYVVDAS 170
Query: 185 ASVEEVHEDIVALVKHEL 202
EV E + +++ L
Sbjct: 171 KDKNEVLEQAIKIIQKNL 188
>sp|Q9UXG7|KTHY_SULSO PROBABLE THYMIDYLATE KINASE (DTMP KINASE)
>gi|6015696|emb|CAB57523.1| (Y18930) thymidylate kinase
[Sulfolobus solfataricus]
Length = 189
Score = 119 bits (296), Expect = 2e-26
Identities = 73/198 (36%), Positives = 115/198 (57%), Gaps = 15/198 (7%)
Query: 6 VVLEGIDGSGKTTQAKLLAEWFEEQ-GWDVLLTKEPTDTEFGRLIRELVLKNSIIDGSRI 64
+ +EGIDGSGKTT A LL E E + +V++T+EP + +LI ++ + I+
Sbjct: 5 IAIEGIDGSGKTTLANLLKEHLESKMKLNVIVTREPFSEDIIKLIEKIGWNDPIL----- 59
Query: 65 SYEAEALLFAADRAEHVKKVILPALEKGKVVICDRYLYSSLAYQWARGLSLEWLMQINSF 124
LLFAADR HV L ++ ++I DRY +SS+AYQ A G+ +W+ +NS+
Sbjct: 60 ----LVLLFAADREIHVNW--LSKIKDADLIILDRYYFSSIAYQGALGVDEQWIKMVNSY 113
Query: 125 APRPDLAILLDLPVKESIRRTKARGNMSEFDKLLELQRKVRMNYLKLAEMFKEMRIVNAM 184
P+PD+ ILLDLP++ +I R K + F++ ++ KVR YLKLA+ + +V+A
Sbjct: 114 FPKPDMVILLDLPIEVAISRIK--NDKFNFEEKIKSLAKVREKYLKLAKEY-NFYVVDAS 170
Query: 185 ASVEEVHEDIVALVKHEL 202
EV E + +++ L
Sbjct: 171 KDKNEVLEQAIKIIQKNL 188
>dbj|BAB03761.1| (AP001507) thymidylate kinase [Bacillus halodurans]
Length = 210
Score = 118 bits (292), Expect = 6e-26
Identities = 76/209 (36%), Positives = 119/209 (56%), Gaps = 11/209 (5%)
Query: 2 RGYFVVLEGIDGSGKTTQAKLLAEWFEEQGWDVLLTKEPTDTEFGRLIRELVLKNSIIDG 61
+G F+ +EG +G+GKT+ + E E G V+ T+EP IR ++L +D
Sbjct: 3 KGCFITVEGGEGAGKTSALDAIEEMLRENGLSVVRTREPGGIPIAEQIRSIILD---VDH 59
Query: 62 SRISYEAEALLFAADRAEHVKKVILPALEKGKVVICDRYLYSSLAYQ-WARGLSLEWLMQ 120
+R+ EALL+AA R +H+ + +LPALE G VV+CDR++ SSLAYQ +ARG+ E ++
Sbjct: 60 TRMDPRTEALLYAAARRQHLVEKVLPALEAGHVVLCDRFIDSSLAYQGYARGIGFEDILA 119
Query: 121 INSFAPR---PDLAIL--LDLPVKES-IRRTKARGNMSEFDKLLELQRKVRMNYLKLAEM 174
IN FA PDL +L +D V S I R ++R + L +KV+ Y ++ E
Sbjct: 120 INEFAIEGRYPDLTLLFRVDPDVGLSRIHRDQSREQNRLDQEALTFHQKVKEGYERIVET 179
Query: 175 FKEMRI-VNAMASVEEVHEDIVALVKHEL 202
+ E + ++A S ++V D V ++K L
Sbjct: 180 YPERVVEIDANQSFDQVVADAVRMIKQRL 208
>pir||H71333 probable thymidylate kinase (tmk) - syphilis spirochete
>gi|3322633|gb|AAC65341.1| (AE001215) thymidylate kinase
(tmk) [Treponema pallidum]
Length = 208
Score = 117 bits (290), Expect = 1e-25
Identities = 73/199 (36%), Positives = 112/199 (55%), Gaps = 15/199 (7%)
Query: 5 FVVLEGIDGSGKTTQAKLLAEWFEEQGWDVLLTKEPTDTEFGRLIRELVLKNSIIDGSRI 64
FVV EGIDG+G +TQ + L F+ + D++ T+EPT E G LIR+++ K I+
Sbjct: 7 FVVFEGIDGTGTSTQLRALERHFQARK-DMVFTQEPTGGEIGTLIRDVLQKRVIM----- 60
Query: 65 SYEAEALLFAADRAEHVKKV--ILPALEKGKVVICDRYLYSSLAYQWARGLSLEWLMQIN 122
S +A LLFAADR EH++ I L +GK+V+CDRY++SSL YQ +S + ++N
Sbjct: 61 SSKALGLLFAADRHEHLEGAGGINDCLAEGKIVLCDRYVFSSLVYQ-GMAVSGSFAYELN 119
Query: 123 SFAPRPDLAILLDLPVKESIRRTKARGNMSEFDKLLELQRKVRMNY----LKLAEMFKEM 178
P P++ D P++ + R ARG +E + Q K R Y K ++ M
Sbjct: 120 KEFPLPEVVFYFDAPIEVCVERITARGLQTELYEYTSFQEKARKGYETIFRKCRHLYPAM 179
Query: 179 RI--VNAMASVEEVHEDIV 195
++ ++A +E VHE I+
Sbjct: 180 KVIEIDAREEIEVVHERIL 198
>sp|Q9X0I3|KTHY_THEMA THYMIDYLATE KINASE (DTMP KINASE) >gi|7434647|pir||E72294
thymidylate kinase - Thermotoga maritima (strain MSB8)
>gi|4981644|gb|AAD36175.1|AE001769_5 (AE001769)
thymidylate kinase [Thermotoga maritima]
Length = 197
Score = 115 bits (284), Expect = 5e-25
Identities = 77/200 (38%), Positives = 117/200 (58%), Gaps = 16/200 (8%)
Query: 5 FVVLEGIDGSGKTTQAKLLAEWFEEQGWDVLLTKEPTDTEFGRLIRELVLKNSIIDGSRI 64
F+ EGIDGSGK+TQ +LLA++ E++G V+L +EP TE G IR+++L+ +
Sbjct: 2 FITFEGIDGSGKSTQIQLLAQYLEKRGKKVILKREPGGTETGEKIRKILLE------EEV 55
Query: 65 SYEAEALLFAADRAEHVKKVILPALEKGKVVICDRYLYSSLAYQ-WARGLSLEWLMQINS 123
+ +AE LF A R V + I L +G V+ DRY SS+AYQ + R L E + ++N
Sbjct: 56 TPKAELFLFLASRNLLVTE-IKQYLSEGYAVLLDRYTDSSVAYQGFGRNLGKEIVEELND 114
Query: 124 FAPR---PDLAILLDLPVKESIRRTKARGNMSEFDKLLELQRKVRMNYLKLAEMFKEMRI 180
FA PDL +D+ V+ +++R +G ++ F+K E +VR YL LA E +
Sbjct: 115 FATDGLIPDLTFYIDVDVETALKR---KGELNRFEK-REFLERVREGYLVLAREHPERIV 170
Query: 181 V-NAMASVEEVHEDIVALVK 199
V + S+EE+H D+V VK
Sbjct: 171 VLDGKRSIEEIHRDVVREVK 190
>pir||D75560 thymidylate kinase - Deinococcus radiodurans (strain R1)
>gi|6457772|gb|AAF09698.1|AE001873_8 (AE001873)
thymidylate kinase [Deinococcus radiodurans]
Length = 206
Score = 115 bits (284), Expect = 5e-25
Identities = 78/203 (38%), Positives = 112/203 (54%), Gaps = 10/203 (4%)
Query: 2 RGYFVVLEGIDGSGKTTQAKLLAEWFEEQGWDVLLTKEPTDTEFGRLIRELVLKNSIIDG 61
+G F+ LEG +G+GKTTQ L G V +T+EP T G +RE+VL ++
Sbjct: 3 QGLFITLEGPEGAGKTTQLARLEARLRAAGHAVTVTREPGGTPLGTRVREVVLDPAV--- 59
Query: 62 SRISYEAEALLFAADRAEHVKKVILPALEKGKVVICDRYLYSSLAYQWA-RGLSLEWLMQ 120
I E LL++A RA+ V++V+ PALE+G+ V+CDRY SSLAYQ A RGLSL L Q
Sbjct: 60 -EIEPLGEFLLYSASRAQLVREVLRPALERGETVLCDRYADSSLAYQGAGRGLSLPLLRQ 118
Query: 121 INSFAP---RPDLAILLDLPVKESIRRTKARGNMSEFDKL-LELQRKVRMNYLKLAEMF- 175
I + P L +LLDL ++R RG ++ L R+VR +L LA
Sbjct: 119 ITAEVTGGLTPGLTVLLDLDPALGLQRAARRGQPDRLEQADLTFHRRVRQGFLDLAHAEP 178
Query: 176 KEMRIVNAMASVEEVHEDIVALV 198
+ +++A +E+ +I A V
Sbjct: 179 QRFLVLDATRPEDELEAEIWAAV 201
>pir||E83275 thymidylate kinase PA2962 [imported] - Pseudomonas aeruginosa
(strain PAO1) >gi|9949060|gb|AAG06350.1|AE004722_6
(AE004722) thymidylate kinase [Pseudomonas aeruginosa]
Length = 210
Score = 113 bits (281), Expect = 1e-24
Identities = 78/208 (37%), Positives = 113/208 (53%), Gaps = 9/208 (4%)
Query: 1 MRGYFVVLEGIDGSGKTTQAKLLAEWFEEQGWDVLLTKEPTDTEFGRLIRELVLKNSIID 60
M G FV LEG +G+GK+T LAE E+G +V LT+EP T IREL+L S
Sbjct: 1 MTGLFVTLEGPEGAGKSTNRDYLAERLRERGIEVQLTREPGGTPLAERIRELLLAPS--- 57
Query: 61 GSRISYEAEALLFAADRAEHVKKVILPALEKGKVVICDRYLYSSLAYQ-WARGLSLEWLM 119
++ + E LL A RA+H+ VI PAL +G VV+CDR+ ++ AYQ RGL +
Sbjct: 58 DEPMAADTELLLMFAARAQHLAGVIRPALARGAVVLCDRFTDATYAYQGGGRGLPEARIA 117
Query: 120 QINSFAP---RPDLAILLDLPVKESIRRTKARGNMSEFDKL-LELQRKVRMNYLKLAEMF 175
+ SF RPDL ++ DLPV+ + R ARG + F++ VR YL+ A
Sbjct: 118 ALESFVQGDLRPDLTLVFDLPVEIGLARAAARGRLDRFEQEDRRFFEAVRQTYLQRAAQA 177
Query: 176 KE-MRIVNAMASVEEVHEDIVALVKHEL 202
E ++++A + EV + L+ + L
Sbjct: 178 PERYQVLDAGLPLAEVQAGLDRLLPNLL 205
>pir||G81700 thymidylate kinase TC0460 [imported] - Chlamydia muridarum (strain
Nigg) >gi|7190503|gb|AAF39311.1| (AE002314) thymidylate
kinase [Chlamydia muridarum]
Length = 203
Score = 110 bits (272), Expect = 1e-23
Identities = 72/192 (37%), Positives = 109/192 (56%), Gaps = 12/192 (6%)
Query: 5 FVVLEGIDGSGKTTQAKLLAEWFEEQGWDVLLTKEPTDTEFGRLIRELVLKNSIIDGSRI 64
F+V+EG +G+GKT + L++ E+G +V+LT+EP + G +R+LVL + I
Sbjct: 2 FIVVEGGEGAGKTQFTQALSKRLMEEGKEVVLTREPGGSALGEQLRDLVLDVT----QEI 57
Query: 65 SYEAEALLFAADRAEHVKKVILPALEKGKVVICDRYLYSSLAYQW-ARGLSLEWLMQ--- 120
S AE LLF A RA+H+++ ILPALE GK VICDR+ S++ YQ A GL ++
Sbjct: 58 SSYAELLLFLAARAQHIQEKILPALESGKTVICDRFHDSTIVYQGIAGGLGEAFVTDLCY 117
Query: 121 --INSFAPRPDLAILLDLPVKESIRRTKARGNMSEFD-KLLELQRKVRMNYLKLAEMFKE 177
+ PD+ LLDLP KE + R + N+ F+ K R R ++ LAE +
Sbjct: 118 RVVGDEPFLPDITFLLDLPEKEGLLRKTRQKNLDRFEQKPTSFHRAAREGFISLAERSPD 177
Query: 178 -MRIVNAMASVE 188
+I++A+ E
Sbjct: 178 RYKILDALLPTE 189
>sp|P37537|KTHY_BACSU THYMIDYLATE KINASE (DTMP KINASE) >gi|2127026|pir||S66058
thymidylate kinase tmk - Bacillus subtilis
>gi|467418|dbj|BAA05264.1| (D26185) unknown [Bacillus
subtilis] >gi|2632295|emb|CAB11804.1| (Z99104)
thymidylate kinase [Bacillus subtilis]
Length = 212
Score = 109 bits (271), Expect = 2e-23
Identities = 71/212 (33%), Positives = 121/212 (56%), Gaps = 15/212 (7%)
Query: 1 MRGYFVVLEGIDGSGKTTQAKLLAEWFEEQGWDVLLTKEPTDTEFGRLIRELVL-KNSII 59
M G F+ EG +G+GKTT + + +G V+ T+EP + IRE++L +N+I+
Sbjct: 1 MSGLFITFEGPEGAGKTTVLQEIKNILTAEGLQVMATREPGGIDIAEQIREVILNENNIL 60
Query: 60 DGSRISYEAEALLFAADRAEHVKKVILPALEKGKVVICDRYLYSSLAYQ-WARGLSLEWL 118
+ + EALL+AA R +H+ + + PALE+G +V+CDR++ S LAYQ +ARGL ++ +
Sbjct: 61 ----MDPKTEALLYAAARRQHLVEKVKPALEQGFIVLCDRFIDSPLAYQGYARGLGIDEV 116
Query: 119 MQINSFA---PRPDLAILLDLPVKESIRRTKARG----NMSEFDKLLELQRKVRMNYLKL 171
+ IN FA P + + + +E ++R A G N + +K L+ KV+ Y +L
Sbjct: 117 LSINEFAIGDMMPHVTVYFSIDPEEGLKRIYANGSREKNRLDLEK-LDFHTKVQEGYQEL 175
Query: 172 AEMFKE-MRIVNAMASVEEVHEDIVALVKHEL 202
+ F E V+A S + V +D++ ++ L
Sbjct: 176 MKRFPERFHSVDAGQSKDLVVQDVLKVIDEAL 207
>sp|O26009|KTHY_HELPY THYMIDYLATE KINASE (DTMP KINASE) >gi|7434648|pir||B64704
thymidylate kinase - Helicobacter pylori (strain 26695)
>gi|2314650|gb|AAD08513.1| (AE000647) thymidylate kinase
(tmk) [Helicobacter pylori 26695]
Length = 191
Score = 109 bits (271), Expect = 2e-23
Identities = 73/201 (36%), Positives = 114/201 (56%), Gaps = 20/201 (9%)
Query: 5 FVVLEGIDGSGKTTQAKLLAEWFEEQGWDVLLTKEPTDTEFGRLIRELVLKNSIIDGSRI 64
+VVLEG+DG+GK+TQ +LL + F+ + L TKEP T G +R + L +I
Sbjct: 2 YVVLEGVDGAGKSTQVELLKDRFK----NALFTKEPGGTRMGESLRRIALNENI------ 51
Query: 65 SYEAEALLFAADRAEHVKKVILPALEKGKVVICDRYLYSSLAYQWARGLSLEWLMQINSF 124
S A A LF +DRAEH + VI PAL++ K++I DR L S +AY L L L+ S
Sbjct: 52 SELARAFLFLSDRAEHTESVIKPALKEKKLIISDRSLISGMAYSQFSSLELN-LLATQSV 110
Query: 125 APRPDLAILLDLPVKESIRRTKARGNMSE-----FDKLLELQRKVRMNYLKLAEMFK-EM 178
P + +L+D KE +++ + ++ + +KLL +Q+K++ + L E F E+
Sbjct: 111 LPAKIILLLID---KEGLKQRLSLKSLDKIENQGIEKLLHIQQKLKTHAYALQEKFGCEV 167
Query: 179 RIVNAMASVEEVHEDIVALVK 199
++A SV+ +HE I A +K
Sbjct: 168 LELDAKESVKNLHEKIAAFIK 188
>sp|O27793|KTHY_METTH PROBABLE THYMIDYLATE KINASE (DTMP KINASE) >gi|7434640|pir||F69102
thymidylate kinase - Methanobacterium
thermoautotrophicum (strain Delta H)
>gi|2622895|gb|AAB86231.1| (AE000932) thymidylate kinase
[Methanobacterium thermoautotrophicum]
Length = 194
Score = 108 bits (268), Expect = 4e-23
Identities = 79/191 (41%), Positives = 101/191 (52%), Gaps = 15/191 (7%)
Query: 5 FVVLEGIDGSGKTTQAKLLAEWFEEQGWDVLLTKEPTDTEFGRLIRELVLKNSIIDGSRI 64
++ EGIDGSGKTT A L A W E G+ V +EPTD+ G LIR ++ S D
Sbjct: 2 YICFEGIDGSGKTTHAALTASWLRENGYMVHEVREPTDSNIGSLIRSML---SSPDARTP 58
Query: 65 SYEAE-ALLFAADRAEHVKKVILPALEKGKVVICDRYLYSSLAYQWARGLSLEWLMQINS 123
+ ALLFAADR K+ E VV+ DR YSS+ YQ EW+ +IN
Sbjct: 59 DVQRMLALLFAADRLTLRSKIEGDWAE--DVVVSDRCYYSSMVYQGPE----EWVCEINR 112
Query: 124 FAPRPDLAILLDLPVKESIRRTKARGNMSEFDKLLELQRKVRMNYLKLAEMFKEMRIVNA 183
FAPRPD+ ILLD+ V+ ++ R G EF+ L L VR YL+LA+ VNA
Sbjct: 113 FAPRPDVVILLDIDVEVAMERC---GGTDEFEDPLYL-AGVRERYLELADK-NGFYTVNA 167
Query: 184 MASVEEVHEDI 194
V + DI
Sbjct: 168 ERGVNLIQRDI 178
>sp|P37345|KTHY_ECOLI THYMIDYLATE KINASE (DTMP KINASE) >gi|2145538|pir||JC6006
thymidylate kinase (EC 2.7.4.9) - Escherichia coli
>gi|7434653|pir||G64853 dTMP kinase (EC 2.7.4.9)
[validated] - Escherichia coli
>gi|1244710|gb|AAB06878.1| (U41456) thymidylate kinase
[Escherichia coli] >gi|1787340|gb|AAC74182.1| (AE000210)
thymidylate kinase [Escherichia coli K12]
>gi|4062665|dbj|BAA35905.1| (D90745) Thymidylate kinase
(EC 2.7.4.9) [Escherichia coli]
Length = 213
Score = 107 bits (265), Expect = 9e-23
Identities = 69/206 (33%), Positives = 110/206 (52%), Gaps = 6/206 (2%)
Query: 1 MRGYFVVLEGIDGSGKTTQAKLLAEWFEEQGW-DVLLTKEPTDTEFGRLIRELVLKNSII 59
MR ++V+EG++G+GKTT ++ E E+ G D++ T+EP T+ +R LVL +
Sbjct: 1 MRSKYIVIEGLEGAGKTTARNVVVETLEQLGIRDMVFTREPGGTQLAEKLRSLVLDIKSV 60
Query: 60 DGSRISYEAEALLFAADRAEHVKKVILPALEKGKVVICDRYLYSSLAYQ-WARGLSLEWL 118
I+ +AE L+F A R + V+ VI PAL G VI DR+ S+ AYQ RG+ L
Sbjct: 61 GDEVITDKAEVLMFYAARVQLVETVIKPALANGTWVIGDRHDLSTQAYQGGGRGIDQHML 120
Query: 119 MQINSFAP---RPDLAILLDLPVKESIRRTKARGNMSEFD-KLLELQRKVRMNYLKLAEM 174
+ RPDL + LD+ + ++R +ARG + + + + + R YL+LA
Sbjct: 121 ATLRDAVLGDFRPDLTLYLDVTPEVGLKRARARGELDRIEQESFDFFNRTRARYLELAAQ 180
Query: 175 FKEMRIVNAMASVEEVHEDIVALVKH 200
K + ++A +E V + I V H
Sbjct: 181 DKSIHTIDATQPLEAVMDAIRTTVTH 206
>sp|Q9RQJ9|KTHY_CAUCR THYMIDYLATE KINASE (DTMP KINASE)
>gi|6318310|gb|AAF06831.1|AF099189_1 (AF099189)
thymydilate kinase [Caulobacter crescentus]
Length = 208
Score = 106 bits (262), Expect = 2e-22
Identities = 71/207 (34%), Positives = 117/207 (56%), Gaps = 9/207 (4%)
Query: 2 RGYFVVLEGIDGSGKTTQAKLLAEWFEEQGWDVLLTKEPTDTEFGRLIRELVLKNSIIDG 61
+G+F+ EG +G+GK+TQ + LA+ + G DV++T+EP + IREL++ +
Sbjct: 3 QGFFISFEGGEGAGKSTQIRRLADRLKAAGHDVIVTREPGGSPGAEAIRELLVNGA---A 59
Query: 62 SRISYEAEALLFAADRAEHVKKVILPALEKGKVVICDRYLYSSLAYQWARG---LSLEWL 118
R S E+LL A R +H+++VI P L +G VV+CDR+ S+ AYQ A G SL
Sbjct: 60 DRWSPVTESLLMYAARRDHIERVIRPGLARGAVVLCDRFADSTRAYQGAGGDAPASLIAA 119
Query: 119 MQINSFAPR-PDLAILLDLPVKESIRRTKARGNMSEFD-KLLELQRKVRMNYLKLAEMFK 176
++ + P L ++LDLP + ++R +ARG + F+ K L ++R YL++A
Sbjct: 120 LEEHVLGGTVPVLTLILDLPAEVGLQRAEARGGAARFESKGLAFHERLRAGYLEIARREP 179
Query: 177 EMRIV-NAMASVEEVHEDIVALVKHEL 202
+ +V +A A ++ V I +V L
Sbjct: 180 DRCVVIDADAELDAVTAAISDVVVQRL 206
>pdb|4TMK|A Chain A, Complex Of E. Coli Thymidylate Kinase With The Bisubstrate
Inhibitor Tp5a >gi|6729850|pdb|5TMP|A Chain A, Complex
Of E. Coli Thymidylate Kinase With The Bisubstrate
Inhibitor Aztp5a
Length = 213
Score = 106 bits (262), Expect = 2e-22
Identities = 68/206 (33%), Positives = 110/206 (53%), Gaps = 6/206 (2%)
Query: 1 MRGYFVVLEGIDGSGKTTQAKLLAEWFEEQGW-DVLLTKEPTDTEFGRLIRELVLKNSII 59
MR ++V+EG++G+GKTT ++ E E+ G D++ T+EP T+ +R L+L +
Sbjct: 1 MRSKYIVIEGLEGAGKTTARNVVVETLEQLGIRDMVFTREPGGTQLAEKLRSLLLDIKSV 60
Query: 60 DGSRISYEAEALLFAADRAEHVKKVILPALEKGKVVICDRYLYSSLAYQ-WARGLSLEWL 118
I+ +AE L+F A R + V+ VI PAL G VI DR+ S+ AYQ RG+ L
Sbjct: 61 GDEVITDKAEVLMFYAARVQLVETVIKPALANGTWVIGDRHDLSTQAYQGGGRGIDQHML 120
Query: 119 MQINSFAP---RPDLAILLDLPVKESIRRTKARGNMSEFD-KLLELQRKVRMNYLKLAEM 174
+ RPDL + LD+ + ++R +ARG + + + + + R YL+LA
Sbjct: 121 ATLRDAVLGDFRPDLTLYLDVTPEVGLKRARARGELDRIEQESFDFFNRTRARYLELAAQ 180
Query: 175 FKEMRIVNAMASVEEVHEDIVALVKH 200
K + ++A +E V + I V H
Sbjct: 181 DKSIHTIDATQPLEAVMDAIRTTVTH 206
>gb|AAA93511.1| (L37441) thymidine:thymidylate kinase:zeocin resistance fusion
protein [Cloning vector pZEO-SG3]
Length = 560
Score = 105 bits (260), Expect = 4e-22
Identities = 68/205 (33%), Positives = 109/205 (53%), Gaps = 6/205 (2%)
Query: 2 RGYFVVLEGIDGSGKTTQAKLLAEWFEEQGW-DVLLTKEPTDTEFGRLIRELVLKNSIID 60
R ++V+EG++G+GKTT ++ E E+ G D++ T+EP T+ +R LVL +
Sbjct: 217 RSKYIVIEGLEGAGKTTARNVVVETLEQLGIRDMVFTREPGGTQLAEKLRSLVLDIKSVG 276
Query: 61 GSRISYEAEALLFAADRAEHVKKVILPALEKGKVVICDRYLYSSLAYQ-WARGLSLEWLM 119
I+ +AE L+F A R + V+ VI PAL G VI DR+ S+ AYQ RG+ L
Sbjct: 277 DEVITDKAEVLMFYAARVQLVETVIKPALANGTWVIGDRHDLSTQAYQGGGRGIDQHMLA 336
Query: 120 QINSFAP---RPDLAILLDLPVKESIRRTKARGNMSEFD-KLLELQRKVRMNYLKLAEMF 175
+ RPDL + LD+ + ++R +ARG + + + + + R YL+LA
Sbjct: 337 TLRDAVLGDFRPDLTLYLDVTPEVGLKRARARGELDRIEQESFDFFNRTRARYLELAAQD 396
Query: 176 KEMRIVNAMASVEEVHEDIVALVKH 200
K + ++A +E V + I V H
Sbjct: 397 KSIHTIDATQPLEAVMDAIRTTVTH 421
>gb|AAA93513.1| (L37442) thymidylate:zeocin resistance protein:NDP kinase fusion
protein [Cloning vector pZEO-SG4]
Length = 494
Score = 105 bits (260), Expect = 4e-22
Identities = 68/205 (33%), Positives = 109/205 (53%), Gaps = 6/205 (2%)
Query: 2 RGYFVVLEGIDGSGKTTQAKLLAEWFEEQGW-DVLLTKEPTDTEFGRLIRELVLKNSIID 60
R ++V+EG++G+GKTT ++ E E+ G D++ T+EP T+ +R LVL +
Sbjct: 3 RSKYIVIEGLEGAGKTTARNVVVETLEQLGIRDMVFTREPGGTQLAEKLRSLVLDIKSVG 62
Query: 61 GSRISYEAEALLFAADRAEHVKKVILPALEKGKVVICDRYLYSSLAYQ-WARGLSLEWLM 119
I+ +AE L+F A R + V+ VI PAL G VI DR+ S+ AYQ RG+ L
Sbjct: 63 DEVITDKAEVLMFYAARVQLVETVIKPALANGTWVIGDRHDLSTQAYQGGGRGIDQHMLA 122
Query: 120 QINSFAP---RPDLAILLDLPVKESIRRTKARGNMSEFD-KLLELQRKVRMNYLKLAEMF 175
+ RPDL + LD+ + ++R +ARG + + + + + R YL+LA
Sbjct: 123 TLRDAVLGDFRPDLTLYLDVTPEVGLKRARARGELDRIEQESFDFFNRTRARYLELAAQD 182
Query: 176 KEMRIVNAMASVEEVHEDIVALVKH 200
K + ++A +E V + I V H
Sbjct: 183 KSIHTIDATQPLEAVMDAIRTTVTH 207
>pir||H81932 probable dTMP kinase (EC 2.7.4.9) NMA0869 [imported] - Neisseria
meningitidis (group A strain Z2491)
>gi|7379584|emb|CAB84149.1| (AL162754) putative
thymidylate kinase [Neisseria meningitidis Z2491]
Length = 206
Score = 105 bits (260), Expect = 4e-22
Identities = 68/200 (34%), Positives = 107/200 (53%), Gaps = 10/200 (5%)
Query: 1 MRGYFVVLEGIDGSGKTTQAKLLAEWFEEQGWDVLLTKEPTDTEFGRLIRELVLKNSIID 60
M+ F+ L+GIDG+GK+T ++ WFE +G VL T+EP T G +RE++L
Sbjct: 1 MKPQFITLDGIDGAGKSTNLAVIKAWFERRGLPVLFTREPGGTPVGEALREILLNPETKA 60
Query: 61 GSRISYEAEALLFAADRAEHVKKVILPALEKGKVVICDRYLYSSLAYQ-WARGLSLEWLM 119
G R AE L+ A R +H++ VILPAL G V+ DR+ ++ AYQ RG+ E +
Sbjct: 61 GLR----AETLMMFAARMQHIEDVILPALSDGIHVVSDRFTDATFAYQGGGRGMPSEDIE 116
Query: 120 QINSFAP---RPDLAILLDLPVKESIRRTKARGNMSEFD-KLLELQRKVRMNYLKLAEMF 175
+ + RPDL +LLD+P++ S+ R F+ + + +VR YL A
Sbjct: 117 ILEHWVQGGLRPDLTLLLDVPLEVSMARIGQTREKDRFEQEQADFFMRVRSVYLNRAAAC 176
Query: 176 KE-MRIVNAMASVEEVHEDI 194
E ++++ ++EV I
Sbjct: 177 PERYAVIDSNLGLDEVRNSI 196
>pir||B81173 thymidylate kinase NMB0670 [imported] - Neisseria meningitidis
(group B strain MD58) >gi|7225896|gb|AAF41088.1|
(AE002421) thymidylate kinase [Neisseria meningitidis
MC58]
Length = 206
Score = 104 bits (257), Expect = 8e-22
Identities = 67/200 (33%), Positives = 109/200 (54%), Gaps = 10/200 (5%)
Query: 1 MRGYFVVLEGIDGSGKTTQAKLLAEWFEEQGWDVLLTKEPTDTEFGRLIRELVLKNSIID 60
M+ F+ L+GIDG+GK+T ++ WFE +G VL T+EP T G +RE++L
Sbjct: 1 MKPQFITLDGIDGAGKSTNLAVIKAWFERRGLPVLFTREPGGTPVGEALREILLNPETKA 60
Query: 61 GSRISYEAEALLFAADRAEHVKKVILPALEKGKVVICDRYLYSSLAYQ-WARGLSLEWLM 119
G R AE L+ A R +H+++VILPAL G V+ DR+ ++ AYQ RG+ E +
Sbjct: 61 GLR----AETLMMFAARMQHIEEVILPALSDGIHVVSDRFTDATFAYQGGGRGMPSEDIE 116
Query: 120 QINSFAP---RPDLAILLDLPVKESIRRTKARGNMSEFD-KLLELQRKVRMNYLKLAEMF 175
+ + +PDL +LLD+P++ S+ R F+ + + +VR YL A
Sbjct: 117 ILEHWVQGGLKPDLTLLLDVPLEVSMARIGQTREKDRFEQEQADFFMRVRGVYLDRAAAC 176
Query: 176 KE-MRIVNAMASVEEVHEDI 194
E ++++ +++EV I
Sbjct: 177 PERYAVIDSNRNLDEVRNSI 196
>sp|Q9ZJE5|KTHY_HELPJ THYMIDYLATE KINASE (DTMP KINASE) >gi|7434649|pir||B71814
thymidylate kinase - Helicobacter pylori (strain J99)
>gi|4155994|gb|AAD06956.1| (AE001560) THYMIDYLATE KINASE
[Helicobacter pylori J99]
Length = 191
Score = 104 bits (256), Expect = 1e-21
Identities = 69/201 (34%), Positives = 113/201 (55%), Gaps = 20/201 (9%)
Query: 5 FVVLEGIDGSGKTTQAKLLAEWFEEQGWDVLLTKEPTDTEFGRLIRELVLKNSIIDGSRI 64
+VVLEG+DG+GK+TQ LL + F+ + L TKEP T G +R + L +I
Sbjct: 2 YVVLEGVDGAGKSTQVGLLKDRFK----NALFTKEPGGTRMGESLRRIALNENI------ 51
Query: 65 SYEAEALLFAADRAEHVKKVILPALEKGKVVICDRYLYSSLAYQWARGLSLEWLMQINSF 124
S A A LF +DRAEH++ VI PAL++ K++I DR L S +AY L L L+ S
Sbjct: 52 SELARAFLFLSDRAEHIESVIKPALKEKKLIISDRSLISGMAYSQFSSLELN-LLATQSV 110
Query: 125 APRPDLAILLDLPVKESIRRTKARGNMSE-----FDKLLELQRKVRMNYLKLAEMFK-EM 178
P + +L++ KE++++ + ++ + +KLL +Q+K++ + L E F E+
Sbjct: 111 LPEKIILLLIN---KENLKQRLSLKSLDKIENQGIEKLLTIQQKLKTHAYALQEKFGCEV 167
Query: 179 RIVNAMASVEEVHEDIVALVK 199
++A S + +HE I ++
Sbjct: 168 LELDAQKSAKNLHEKIATFIE 188
>sp|O69169|KTHY_YERPE THYMIDYLATE KINASE (DTMP KINASE) >gi|3176887|gb|AAC18855.1|
(AF065312) thymidylate kinase [Yersinia pestis]
Length = 212
Score = 102 bits (253), Expect = 2e-21
Identities = 66/200 (33%), Positives = 106/200 (53%), Gaps = 8/200 (4%)
Query: 1 MRGYFVVLEGIDGSGKTTQAKLLAEWFEEQGW-DVLLTKEPTDTEFGRLIRELVLKNSII 59
M F+V+EG++G+GKTT + QG D++ T+EP T +R+L+ + I
Sbjct: 1 MNSKFIVIEGLEGAGKTTTRDTVVAVLRAQGINDIVFTREPGGTPLAEKLRDLIKQG--I 58
Query: 60 DGSRISYEAEALLFAADRAEHVKKVILPALEKGKVVICDRYLYSSLAYQ-WARGLSLEWL 118
DG ++ +AE L+ A R + V+ VI PAL +G V+ DR+ SS AYQ RG+ + +
Sbjct: 59 DGEVLTDKAEVLMLYAARVQLVENVIKPALARGSWVVGDRHDLSSQAYQGGGRGIDSQLM 118
Query: 119 MQINSFAP---RPDLAILLDLPVKESIRRTKARGNMSEFD-KLLELQRKVRMNYLKLAEM 174
+ RPDL + LDLP + R +ARG + + + L + R YL+LA
Sbjct: 119 ASLRDTVLGEFRPDLTLYLDLPPAVGLARARARGELDRIEQESLAFFERTRARYLELAAS 178
Query: 175 FKEMRIVNAMASVEEVHEDI 194
++ ++A +E+V I
Sbjct: 179 DASIKTIDASQPIEQVSASI 198
>pir||S76121 hypothetical protein - Synechocystis sp. (strain PCC 6803)
>gi|1001473|dbj|BAA10099.1| (D63999) hypothetical
protein [Synechocystis sp.]
Length = 236
Score = 101 bits (250), Expect = 5e-21
Identities = 73/216 (33%), Positives = 113/216 (51%), Gaps = 18/216 (8%)
Query: 1 MRGYFVVLEGIDGSGKTTQAKLLAEWFEEQGWDVLLTKEPTDTEFGRLIRELVLKNSIID 60
M F+VLEGIDGSGKTTQ LL F+ QG +L+ EPT+ GRLIR+ + +
Sbjct: 25 MAALFIVLEGIDGSGKTTQGDLLLAHFQRQGLAAVLSPEPTNGPVGRLIRQALQGDLFTY 84
Query: 61 GSRISYEAE-ALLFAADRAEHVKKV---ILPALEKGKVVICDRYLYSSLAYQWARGLSLE 116
+EA+ LFAADR H+ + L + VI RY +SSLAY E
Sbjct: 85 NDARQFEAQMGYLFAADRHYHLYHPGDGVEAKLAQQCHVITTRYYFSSLAYNCHTEADWE 144
Query: 117 WLMQINSFAPRPDLAILLDLPVKESIRRTKARGNM---------SEFDKLLELQRKVRMN 167
++ ++N P+PD I LDLPV +++R R + + +KL+ + R N
Sbjct: 145 FVQRLNQSFPQPDWVIYLDLPVDLALQRLGDRQQLEDQAPRECYEQREKLISVHR----N 200
Query: 168 YLKLAEMFK-EMRIVNAMASVEEVHEDIVALVKHEL 202
Y ++ ++ ++ ++A VE++H+ I+ V+ L
Sbjct: 201 YDRIFAHYQGQLCRLDASLPVEQLHQAIITKVEEML 236
>sp|Q55593|KTHY_SYNY3 THYMIDYLATE KINASE (DTMP KINASE)
Length = 212
Score = 101 bits (250), Expect = 5e-21
Identities = 73/216 (33%), Positives = 113/216 (51%), Gaps = 18/216 (8%)
Query: 1 MRGYFVVLEGIDGSGKTTQAKLLAEWFEEQGWDVLLTKEPTDTEFGRLIRELVLKNSIID 60
M F+VLEGIDGSGKTTQ LL F+ QG +L+ EPT+ GRLIR+ + +
Sbjct: 1 MAALFIVLEGIDGSGKTTQGDLLLAHFQRQGLAAVLSPEPTNGPVGRLIRQALQGDLFTY 60
Query: 61 GSRISYEAE-ALLFAADRAEHVKKV---ILPALEKGKVVICDRYLYSSLAYQWARGLSLE 116
+EA+ LFAADR H+ + L + VI RY +SSLAY E
Sbjct: 61 NDARQFEAQMGYLFAADRHYHLYHPGDGVEAKLAQQCHVITTRYYFSSLAYNCHTEADWE 120
Query: 117 WLMQINSFAPRPDLAILLDLPVKESIRRTKARGNM---------SEFDKLLELQRKVRMN 167
++ ++N P+PD I LDLPV +++R R + + +KL+ + R N
Sbjct: 121 FVQRLNQSFPQPDWVIYLDLPVDLALQRLGDRQQLEDQAPRECYEQREKLISVHR----N 176
Query: 168 YLKLAEMFK-EMRIVNAMASVEEVHEDIVALVKHEL 202
Y ++ ++ ++ ++A VE++H+ I+ V+ L
Sbjct: 177 YDRIFAHYQGQLCRLDASLPVEQLHQAIITKVEEML 212
>sp|P47252|KTHY_MYCGE THYMIDYLATE KINASE (DTMP KINASE) >gi|1361866|pir||F64200
thymidylate kinase (CDC8) homolog - Mycoplasma
genitalium >gi|1045674|gb|AAC71222.1| (U39679)
thymidylate kinase (tmk) [Mycoplasma genitalium]
Length = 210
Score = 101 bits (248), Expect = 9e-21
Identities = 68/207 (32%), Positives = 114/207 (54%), Gaps = 16/207 (7%)
Query: 2 RGYFVVLEGIDGSGKTTQAKLLAEWFEEQ--GWDVLLTKEPTDTEFGRLIRELVLKNSII 59
+G FVV+EG+DG+GKT + + + + + + T+EP T IR+L+L ++
Sbjct: 3 KGVFVVIEGVDGAGKTALIEGFKKLYPTKFLNYQLTYTREPGGTLLAEKIRQLLLNETM- 61
Query: 60 DGSRISYEAEALLFAADRAEHVKKVILPALEKGKVVICDRYLYSSLAYQ-WARGLSLEWL 118
EA LFAA R EH+ K+I PA+EK ++VI DR+++SS AYQ ++ + ++ +
Sbjct: 62 -----EPLTEAYLFAAARTEHISKLIKPAIEKEQLVISDRFVFSSFAYQGLSKKIGIDTV 116
Query: 119 MQINSFAPR---PDLAILLDLPVKESIRRTKARGNMSEFDKLLELQR---KVRMNYLKLA 172
QIN A R P+ +LD KE+++R + RGN + D+ ++ + VR YL L
Sbjct: 117 KQINHHALRNMMPNFTFILDCNFKEALQRMQKRGNDNLLDEFIKGKNDFDTVRSYYLSLV 176
Query: 173 EMFKEMRIVNAMASVEEVHEDIVALVK 199
+ K ++N E + + I L +
Sbjct: 177 DK-KNCFLINGDNKQEHLEKFIELLTR 202
>sp|O84191|KTHY_CHLTR THYMIDYLATE KINASE (DTMP KINASE) >gi|7434652|pir||E71546 probable
thymidylate kinase - Chlamydia trachomatis (serotype D,
strain UW3/Cx) >gi|3328593|gb|AAC67780.1| (AE001292)
Thymidylate Kinase [Chlamydia trachomatis]
Length = 203
Score = 98.7 bits (242), Expect = 5e-20
Identities = 68/206 (33%), Positives = 117/206 (56%), Gaps = 16/206 (7%)
Query: 5 FVVLEGIDGSGKTTQAKLLAEWFEEQGWDVLLTKEPTDTEFGRLIRELVLKNSIIDGSRI 64
F+V+EG +G+GKT + L++ E+G +++ T+EP G +R L+L +I
Sbjct: 2 FIVVEGGEGAGKTQFIQALSKRLIEEGREIVTTREPGGCSLGDSVRGLLLDPE----QKI 57
Query: 65 SYEAEALLFAADRAEHVKKVILPALEKGKVVICDRYLYSSLAYQW-ARGLSLEWLMQ--- 120
S AE LLF A RA+H+++ I+PAL+ GK VI DR+ S++ YQ A GL ++
Sbjct: 58 SPYAELLLFLAARAQHIQEKIIPALKSGKTVISDRFHDSTIVYQGIAGGLGESFVTNLCY 117
Query: 121 --INSFAPRPDLAILLDLPVKESIRRTKARGNMSEFDKLLEL-QRKVRMNYLKLAEMFKE 177
+ PD+ LLD+P +E + R + ++ +F++ ++ R VR +L LAE +
Sbjct: 118 HVVGDKPFLPDITFLLDIPAREGLLRKARQKHLDKFEQKPQIFHRSVREGFLALAEKAPD 177
Query: 178 -MRIVNAM----ASVEEVHEDIVALV 198
++++A+ ASV++ I AL+
Sbjct: 178 RYKVLDALLPTEASVDQALLQIRALI 203
>pir||T41553 thymidylate kinase - fission yeast (Schizosaccharomyces pombe)
>gi|3192027|emb|CAA19357.1| (AL023794) thymidylate
kinase [Schizosaccharomyces pombe]
Length = 210
Score = 98.3 bits (241), Expect = 6e-20
Identities = 71/204 (34%), Positives = 112/204 (54%), Gaps = 14/204 (6%)
Query: 2 RGYFVVLEGIDGSGKTTQAKLLAEWFEEQGWDVLLTKEPT-DTEFGRLIRELVLKNSIID 60
RG +V+EG+D SGK+TQ +LL + Q L K P T G+ I + LK S+
Sbjct: 6 RGRLIVIEGLDRSGKSTQCQLLVDKLISQHEKAELFKFPDRTTAIGKKIDDY-LKESV-- 62
Query: 61 GSRISYEAEALLFAADRAEHVKKVILPALEKGKVVICDRYLYSSLAYQWARGLSLEWLMQ 120
+++ + LLF+A+R E ++ I + KG I DRY +S +A+ A+GL EW
Sbjct: 63 --QLNDQVIHLLFSANRWETIQ-YIYEQINKGVTCILDRYAFSGIAFSAAKGLDWEWCKS 119
Query: 121 INSFAPRPDLAILLDLPVKESIRRTKARGNMSEFDKLLELQRKVRMNYLKLAEMFKEMRI 180
+ PRPDL I L+ V I T+ + ++K +E+Q KV N+ +L + F+E +
Sbjct: 120 PDRGLPRPDLVIFLN--VDPRIAATRGQYGEERYEK-IEMQEKVLKNFQRLQKEFREEGL 176
Query: 181 ----VNAMASVEEVHEDIVALVKH 200
++A +S+E+VH IV LV +
Sbjct: 177 EFITLDASSSLEDVHSQIVDLVSN 200
>sp|Q9Z8R5|KTHY_CHLPN THYMIDYLATE KINASE (DTMP KINASE) >gi|7434651|pir||F72098
thymidylate kinase CP0486 [imported] - Chlamydophila
pneumoniae (strains CWL029 and AR39)
>gi|4376546|gb|AAD18422.1| (AE001612) Thymidylate Kinase
[Chlamydophila pneumoniae CWL029]
>gi|7189404|gb|AAF38316.1| (AE002210) thymidylate kinase
[Chlamydophila pneumoniae AR39]
>gi|8978647|dbj|BAA98483.1| (AP002546) thymidylate
kinase [Chlamydophila pneumoniae J138]
Length = 206
Score = 97.9 bits (240), Expect = 8e-20
Identities = 68/208 (32%), Positives = 112/208 (53%), Gaps = 12/208 (5%)
Query: 5 FVVLEGIDGSGKTTQAKLLAEWFEEQGWDVLLTKEPTDTEFGRLIRELVLKNSIIDGSRI 64
F+V+EG +GSGK++ AK L + Q VLLT+EP G +R+L+L+ ++ SR
Sbjct: 2 FIVIEGGEGSGKSSLAKALGDQLVAQDRKVLLTREPGGCLIGERLRDLILEPPHLELSRC 61
Query: 65 SYEAEALLFAADRAEHVKKVILPALEKGKVVICDRYLYSSLAYQW-ARGLSLEWLMQINS 123
E LF RA+H+++VI+PAL G +VIC+R+ S++ YQ A GL +++ + S
Sbjct: 62 ---CELFLFLGSRAQHIQEVIIPALRDGYIVICERFHDSTIVYQGIAEGLGADFVADLCS 118
Query: 124 --FAPR---PDLAILLDLPVKESIRRTKARGNMSEFDKL-LELQRKVRMNYLKLAEMFKE 177
P P+ +LLD+P ++R + +F+K L ++R +L LA
Sbjct: 119 KVVGPTPFLPNFVLLLDIPADIGLQRKHRQKVFDKFEKKPLSYHNRIREGFLSLASADPS 178
Query: 178 MRIVNAMASVEEVHEDIVALVKHELLGL 205
+V + + E + I ++ H LGL
Sbjct: 179 RYLV--LDARESLASLIDKVMLHTQLGL 204
>pir||A64153 dTMP kinase (EC 2.7.4.9) - Haemophilus influenzae (strain Rd KW20)
Length = 237
Score = 96.3 bits (236), Expect = 2e-19
Identities = 65/206 (31%), Positives = 110/206 (52%), Gaps = 9/206 (4%)
Query: 1 MRGYFVVLEGIDGSGKTTQAKLLAEWFEEQG-WDVLLTKEPTDTEFGRLIRELVLKNSII 59
M+G F+V+EG++G+GK++ + + E G DV+ T+EP T +R L+ +
Sbjct: 28 MKGKFIVIEGLEGAGKSSAHQSVVRVLHELGIQDVVFTREPGGTPLAEKLRHLIKHET-- 85
Query: 60 DGSRISYEAEALLFAADRAEHVKKVILPALEKGKVVICDRYLYSSLAYQ-WARGLSLEWL 118
++ +AE L+ A R + V+ VI PAL +GK V+ DR+ SS AYQ R L ++
Sbjct: 86 -EEPVTDKAELLMLYAARIQLVENVIKPALMQGKWVVGDRHDMSSQAYQGGGRQLDPHFM 144
Query: 119 MQINSFAP---RPDLAILLDLPVKESIRRTKARGNMSEFDKL-LELQRKVRMNYLKLAEM 174
+ + PDL I LD+ + R + RG + +++ L+ + R YL+L +
Sbjct: 145 LTLKETVLGNFEPDLTIYLDIDPSVGLARARGRGELDRIEQMDLDFFHRTRARYLELVKD 204
Query: 175 FKEMRIVNAMASVEEVHEDIVALVKH 200
+ ++NA S+E V DI + VK+
Sbjct: 205 NPKAVVINAEQSIELVQADIESAVKN 230
>sp|P44719|KTHY_HAEIN THYMIDYLATE KINASE (DTMP KINASE) >gi|1573430|gb|AAC22114.1|
(U32728) thymidylate kinase [Haemophilus influenzae Rd]
Length = 210
Score = 96.3 bits (236), Expect = 2e-19
Identities = 65/206 (31%), Positives = 110/206 (52%), Gaps = 9/206 (4%)
Query: 1 MRGYFVVLEGIDGSGKTTQAKLLAEWFEEQG-WDVLLTKEPTDTEFGRLIRELVLKNSII 59
M+G F+V+EG++G+GK++ + + E G DV+ T+EP T +R L+ +
Sbjct: 1 MKGKFIVIEGLEGAGKSSAHQSVVRVLHELGIQDVVFTREPGGTPLAEKLRHLIKHET-- 58
Query: 60 DGSRISYEAEALLFAADRAEHVKKVILPALEKGKVVICDRYLYSSLAYQ-WARGLSLEWL 118
++ +AE L+ A R + V+ VI PAL +GK V+ DR+ SS AYQ R L ++
Sbjct: 59 -EEPVTDKAELLMLYAARIQLVENVIKPALMQGKWVVGDRHDMSSQAYQGGGRQLDPHFM 117
Query: 119 MQINSFAP---RPDLAILLDLPVKESIRRTKARGNMSEFDKL-LELQRKVRMNYLKLAEM 174
+ + PDL I LD+ + R + RG + +++ L+ + R YL+L +
Sbjct: 118 LTLKETVLGNFEPDLTIYLDIDPSVGLARARGRGELDRIEQMDLDFFHRTRARYLELVKD 177
Query: 175 FKEMRIVNAMASVEEVHEDIVALVKH 200
+ ++NA S+E V DI + VK+
Sbjct: 178 NPKAVVINAEQSIELVQADIESAVKN 203
>sp|Q9YA48|KTHY_AERPE PROBABLE THYMIDYLATE KINASE (DTMP KINASE) >gi|7434643|pir||E72514
hypothetical protein APE2090 - Aeropyrum pernix (strain
K1) >gi|5105789|dbj|BAA81101.1| (AP000063) 208aa long
hypothetical protein [Aeropyrum pernix]
Length = 208
Score = 96.3 bits (236), Expect = 2e-19
Identities = 74/208 (35%), Positives = 106/208 (50%), Gaps = 14/208 (6%)
Query: 6 VVLEGIDGSGKTTQAKLLAEWFEEQGWDVLLTKEPTDTEFGRLIRELVLKNSIIDGSRIS 65
V LEGIDGSG +T ++LL G L KEPT+ GRLIR + +D
Sbjct: 4 VALEGIDGSGVSTHSRLLHARLAGAGVKSCLWKEPTEGPVGRLIRGFLRSTEGVDS---- 59
Query: 66 YEAEALLFAADRAEHVK-KVILPALEKGKVVICDRYLYSSLAYQWARGLSLEWLMQINSF 124
+ ALLFAADR ++ V+ +V++ DRY YSSLAYQ G LEW+ +N
Sbjct: 60 -DLMALLFAADRLWGLRLGVVERCGGSPEVLVVDRYKYSSLAYQGV-GSGLEWVDAVNRK 117
Query: 125 APRPDLAILLDLPVKESIRRTKARGNMSEFD--KLLELQRKVRMNYLKLAEM--FKEMRI 180
AP ++ + +D+P + ++RR AR F+ + LE + + L+LA K +R+
Sbjct: 118 APEAEILVYIDVPTEVALRRITARERREVFETPEFLERVKSMYEEVLRLARARGVKVIRV 177
Query: 181 VNAMASVEEVHEDI---VALVKHELLGL 205
VE ED+ +A E LGL
Sbjct: 178 EGVRGGVERGIEDVQGEIAERVFEALGL 205
>pir||A82128 thymidylate kinase VC2016 [imported] - Vibrio cholerae (group O1
strain N16961) >gi|9656560|gb|AAF95164.1| (AE004276)
thymidylate kinase [Vibrio cholerae]
Length = 212
Score = 95.2 bits (233), Expect = 5e-19
Identities = 63/200 (31%), Positives = 106/200 (52%), Gaps = 8/200 (4%)
Query: 1 MRGYFVVLEGIDGSGKTTQAKLLAEWFEEQGWD-VLLTKEPTDTEFGRLIRELVLKNSII 59
M F+V+EG++G+GK+T +++ E ++ G D + T+EP T +R LV +
Sbjct: 1 MNAKFIVIEGLEGAGKSTAIQVVVETLQQNGIDHITRTREPGGTLLAEKLRALVKEEH-- 58
Query: 60 DGSRISYEAEALLFAADRAEHVKKVILPALEKGKVVICDRYLYSSLAYQ-WARGLSLEWL 118
G + E LL A R + V+ VI PAL +G+ V+ DR+ SS AYQ R ++ +
Sbjct: 59 PGEELQDITELLLVYAARVQLVENVIKPALARGEWVVGDRHDMSSQAYQGGGRQIAPSTM 118
Query: 119 MQINSFAP---RPDLAILLDLPVKESIRRTKARGNMSEFDKL-LELQRKVRMNYLKLAEM 174
+ A +PDL + LD+ K + R + RG + +K+ + + R YL+LA
Sbjct: 119 QSLKQTALGDFKPDLTLYLDIDPKLGLERARGRGELDRIEKMDISFFERARERYLELANS 178
Query: 175 FKEMRIVNAMASVEEVHEDI 194
+ +++A S+E+V DI
Sbjct: 179 DDSVVMIDAAQSIEQVTADI 198
>sp|Q9ZCN9|KTHY_RICPR THYMIDYLATE KINASE (DTMP KINASE) >gi|7434650|pir||G71674
thymidylate kinase (tmk) RP684 - Rickettsia prowazekii
>gi|3861221|emb|CAA15121.1| (AJ235272) THYMIDYLATE
KINASE (tmk) [Rickettsia prowazekii]
Length = 203
Score = 94.8 bits (232), Expect = 7e-19
Identities = 64/201 (31%), Positives = 108/201 (52%), Gaps = 19/201 (9%)
Query: 2 RGYFVVLEGIDGSGKTTQAKLLAEWFEEQGWDVLLTKEPTDTEFGRLIRELVLKNSIIDG 61
+G F+ EG+DG GK+TQ+K+L E+ + Q V+LT+E T +RE+++ ++
Sbjct: 6 QGKFITFEGVDGIGKSTQSKMLYEYLKSQKIPVILTREVGGTTVAEKMREILVNEELLPM 65
Query: 62 SRISYEAEALLFAADRAEHVKKVILPALEKGKVVICDRYLYSSLAYQWARGLSLEWLMQI 121
S E L A R +H+ + I+PAL+ G +VICDR++ S+ YQ GL LE + +
Sbjct: 66 S------ELLQAMAARYDHMARKIIPALKDGYIVICDRFIDSTACYQ---GLELENGIDL 116
Query: 122 -----NSFAP--RPDLAILLDLPVKESIRRTKARGNMSEFD-KLLELQRKVRMNYLKLAE 173
+ P PD+ +D+ +I+R AR ++FD + ++ +K+ + +L+
Sbjct: 117 VYSLHKTLMPSLMPDITFFIDVEPHTAIKRVNARNMSNKFDIRSIDFYKKIYTCFKELSN 176
Query: 174 MFKE--MRIVNAMASVEEVHE 192
F E I + S EVHE
Sbjct: 177 RFPERIKTIKASHLSPLEVHE 197
>gb|AAK41441.1| Thymidylate kinase (tmK-2) [Sulfolobus solfataricus]
Length = 213
Score = 90.9 bits (222), Expect = 1e-17
Identities = 62/208 (29%), Positives = 109/208 (51%), Gaps = 21/208 (10%)
Query: 1 MRGYFVVLEGIDGSGKTTQAKLLAEWFEEQGWDVLLTKEPTDTEFGRLIRELVLKNSIID 60
MRG + EGIDGSGK++QA LL +W E + DV LT+ + +I+E KN +
Sbjct: 1 MRGLLIAFEGIDGSGKSSQAVLLKDWIEMRR-DVYLTEWNSSEWIHDIIKEAKKKNML-- 57
Query: 61 GSRISYEAEALLFAADRAEHVKKVILPALEKGKVVICDRYLYSSLAYQWARGLSLEWLMQ 120
+ I++ +L+ A D ++ ++ ILP L+ G VVICDRY+Y++ A R + +W+ +
Sbjct: 58 -TSITF---SLIHATDFSDRYERYILPMLKSGFVVICDRYVYTAYARDVVRNVDFDWVKR 113
Query: 121 INSFAPRPDLAILLDLPVK---ESIRRTKAR-----------GNMSEFDKLLELQRKVRM 166
+ SFA +P+ + + + E IR+ K + G + + L+ Q ++
Sbjct: 114 LYSFAIKPNFTFYIRVTPEIALERIRKAKRKIKPQEAGIDILGEIPLEEGFLKYQSRIVE 173
Query: 167 NYLKLAEMFKEMRIVNAMASVEEVHEDI 194
Y K+A+ ++ +++V DI
Sbjct: 174 IYDKIAKEESNFITIDGNRPLKDVQIDI 201
>pir||H82944 thymidylate kinase UU020 [imported] - Ureaplasma urealyticum
>gi|6898965|gb|AAF30425.1|AE002101_8 (AE002101)
thymidylate kinase [Ureaplasma urealyticum]
Length = 233
Score = 89.7 bits (219), Expect = 2e-17
Identities = 70/213 (32%), Positives = 110/213 (50%), Gaps = 17/213 (7%)
Query: 2 RGYFVVLEGIDGSGKTTQAKLLAEWFEEQGW--DVLLTKEP--TDTEFGRLIRELVLKN- 56
+G F+V EGIDG+GKT+ K L E +E + LT+EP + +IRE LKN
Sbjct: 18 KGLFIVFEGIDGAGKTSILKQLLEVLKEPKLVNKIFLTREPGGKNNNAAEMIREFFLKNL 77
Query: 57 SIIDGSRISYEAEALLFAADRAEHVKKVILPALEKGKVVICDRYLYSSLAYQW-ARGLSL 115
+ D ++Y L+A+ RAEHVKK I P LEK +VI DR+++SS YQ + SL
Sbjct: 78 EVFDPLTLAY-----LYASSRAEHVKKTINPHLEKDHIVISDRFVHSSYIYQGIVQNQSL 132
Query: 116 EWLMQINSFA---PRPDLAILLDLPVKESIRRTKAR-GNMSEFD-KLLELQRKVRMNYLK 170
+ + QIN A D D+ V ++ R K R N + FD + + K+ Y
Sbjct: 133 DVIYQINQQAIGELEIDYVFYFDVNVNNALNRMKNRFDNTNAFDSQNKQFYEKLLKQYPS 192
Query: 171 LAEMFKEMRIVNAMASVEEVHEDIVALVKHELL 203
+ +++ + + + + +++ VK +LL
Sbjct: 193 VFKVYNQPKKI-IFIDANKNENEVLCEVKEQLL 224
>sp|P75106|KTHY_MYCPN THYMIDYLATE KINASE (DTMP KINASE) >gi|2146665|pir||S73474
thymidylate kinase - Mycoplasma pneumoniae (strain ATCC
29342) >gi|1673808|gb|AAB95796.1| (AE000016) thymidylate
kinase [Mycoplasma pneumoniae]
Length = 210
Score = 87.0 bits (212), Expect = 2e-16
Identities = 54/166 (32%), Positives = 92/166 (54%), Gaps = 12/166 (7%)
Query: 2 RGYFVVLEGIDGSGKTTQAKLLAEWFEEQ--GWDVLLTKEPTDTEFGRLIRELVLKNSII 59
+G FV +EG+DG+GKT + + F + G+ L ++EP T IR L+L ++
Sbjct: 3 QGVFVAIEGVDGAGKTVLLEAFKQRFPQSFLGFKTLFSREPGGTPLAEKIRALLLHEAM- 61
Query: 60 DGSRISYEAEALLFAADRAEHVKKVILPALEKGKVVICDRYLYSSLAYQ-WARGLSLEWL 118
EA LFAA R EHV+++I PAL++ ++VI DR+++SS AYQ + + L+ +
Sbjct: 62 -----EPLTEAYLFAASRTEHVRQLIQPALQQKQLVIVDRFVWSSYAYQGLIKKVGLDVV 116
Query: 119 MQINSFA---PRPDLAILLDLPVKESIRRTKARGNMSEFDKLLELQ 161
++N+ A PD ++D + ++ R RG + D ++ Q
Sbjct: 117 KKLNADAVGDSMPDFTFIVDCDFETALNRMAKRGQDNLLDNTVKKQ 162
>gb|AAA21719.1| (L16991) thymidylate kinase [Homo sapiens]
Length = 212
Score = 85.8 bits (209), Expect = 3e-16
Identities = 61/198 (30%), Positives = 106/198 (52%), Gaps = 10/198 (5%)
Query: 2 RGYFVVLEGIDGSGKTTQAKLLAEWFEEQGWDVLLTKEP-TDTEFGRLIRELVLKNSIID 60
RG +VLEG+D +GK+TQ++ L E G L + P TE G+L+ + K S ++
Sbjct: 5 RGALIVLEGVDRAGKSTQSRKLVEALCAAGHRAELLRFPERSTEIGKLLSSYLKKKSDVE 64
Query: 61 GSRISYEAEALLFAADRAEHVKKVILPALEKGKVVICDRYLYSSLAYQWAR-GLSLEWLM 119
+ LLF+A+R E V +I L +G ++ DRY +S +A+ A+ SL+W
Sbjct: 65 DHSVH-----LLFSANRWEQV-PLIKEKLSQGVTLVVDRYAFSGVAFTGAKENFSLDWCK 118
Query: 120 QINSFAPRPDLAILLDLPVKESIRRTKARGNMSEFDKLLELQRKVRMNYLKLAEMFKEMR 179
Q + P+PDL + L L + ++ +R A G+ ++ +R +R + + + +
Sbjct: 119 QPDVGLPKPDLVLFLQLQLADAAKR-GAFGH-ERYENGAFQERALRCFHQLMKDTTLNWK 176
Query: 180 IVNAMASVEEVHEDIVAL 197
+V+A S+E VHE++ L
Sbjct: 177 MVDASKSIEAVHEELRVL 194
>gi|6912340 deoxythymidylate kinase (thymidylate kinase) [Homo sapiens]
>gi|284071|pir||S26845 dTMP kinase (EC 2.7.4.9) - human
>gi|37206|emb|CAA38528.1| (X54729) thymidylate kinase
[Homo sapiens]
Length = 211
Score = 83.5 bits (203), Expect = 2e-15
Identities = 59/197 (29%), Positives = 103/197 (51%), Gaps = 9/197 (4%)
Query: 2 RGYFVVLEGIDGSGKTTQAKLLAEWFEEQGWDVLLTKEPTDTEFGRLIRELVLKNSIIDG 61
RG +VLEG+D +GK+TQ++ L E LL TE G+L+ + K S ++
Sbjct: 5 RGALIVLEGVDRAGKSTQSRKLVEALSRGPPPELLRFPERSTEIGKLLSSYLQKKSDVED 64
Query: 62 SRISYEAEALLFAADRAEHVKKVILPALEKGKVVICDRYLYSSLAYQWAR-GLSLEWLMQ 120
+ LLF+A+R E V +I L +G ++ DRY +S +A+ A+ SL+W Q
Sbjct: 65 HSVH-----LLFSANRWEQV-PLIKEKLSQGVTLVVDRYAFSGVAFTGAKENFSLDWCKQ 118
Query: 121 INSFAPRPDLAILLDLPVKESIRRTKARGNMSEFDKLLELQRKVRMNYLKLAEMFKEMRI 180
+ P+PDL + L L + ++ +R A G+ ++ +R +R + + + ++
Sbjct: 119 PDVGLPKPDLVLFLQLQLADAAKR-GAFGH-ERYENGAFQERALRCFHQLMKDTTLNWKM 176
Query: 181 VNAMASVEEVHEDIVAL 197
V+A +E VHE++ L
Sbjct: 177 VDASKRLEAVHEELRVL 193
>sp|P23919|KTHY_HUMAN THYMIDYLATE KINASE (DTMP KINASE)
Length = 212
Score = 83.1 bits (202), Expect = 2e-15
Identities = 60/198 (30%), Positives = 105/198 (52%), Gaps = 10/198 (5%)
Query: 2 RGYFVVLEGIDGSGKTTQAKLLAEWFEEQGWDVLLTKEP-TDTEFGRLIRELVLKNSIID 60
RG +VLEG+D +GK+TQ++ L E G L + P TE G+L+ + K S ++
Sbjct: 5 RGALIVLEGVDRAGKSTQSRKLVEALCAAGHRAELLRFPERSTEIGKLLSSYLQKKSDVE 64
Query: 61 GSRISYEAEALLFAADRAEHVKKVILPALEKGKVVICDRYLYSSLAYQWAR-GLSLEWLM 119
+ LLF+A+R E V +I L +G ++ DRY +S +A+ A+ SL+W
Sbjct: 65 DHSVH-----LLFSANRWEQV-PLIKEKLSQGVTLVVDRYAFSGVAFTGAKENFSLDWCK 118
Query: 120 QINSFAPRPDLAILLDLPVKESIRRTKARGNMSEFDKLLELQRKVRMNYLKLAEMFKEMR 179
Q + P+PDL + L L + ++ +R A G+ ++ +R +R + + + +
Sbjct: 119 QPDVGLPKPDLVLFLQLQLADAAKR-GAFGH-ERYENGAFQERALRCFHQLMKDTTLNWK 176
Query: 180 IVNAMASVEEVHEDIVAL 197
+V+A +E VHE++ L
Sbjct: 177 MVDASKRLEAVHEELRVL 194
>gb|AAG20116.1| (AE005090) thymidylate kinase; Tmk [Halobacterium sp. NRC-1]
Length = 199
Score = 83.1 bits (202), Expect = 2e-15
Identities = 69/204 (33%), Positives = 103/204 (49%), Gaps = 20/204 (9%)
Query: 6 VVLEGIDGSGKTTQAKLLAEWFEEQGWDVLLTKEPTDTEFGRLIRELVLKNSIIDGSRIS 65
V LEG+DGSGKTT + L ++ V T EPTD+++G+ +R S D I
Sbjct: 3 VTLEGLDGSGKTTVWESLRASHDD---GVTFTAEPTDSQYGQAVRR---SESAADADPI- 55
Query: 66 YEAEALLFAADRAEHVKKVILPALEKGKVVICDRYLYSSLAYQWAR-----GLSLEWLMQ 120
AE LF AD A+H+ +V+ PAL++G VVI DRY S AYQ A ++E++
Sbjct: 56 --AELFLFTADHADHLSRVVSPALDRGDVVISDRYSDSRYAYQGATLADTVPRAMEYVRG 113
Query: 121 INS-FAPRPDLAILLDLPVKESIRRTKARGNMSEFDKLLELQRKVRMNYLKLAEMFKEMR 179
I+ + PD+ + D+ R+ G ++F+ L VR NY +L + E
Sbjct: 114 IHQPWTRPPDVTLYFDVDPDTGAARS---GATNKFETAAFL-ADVRANYEQLIDYTPERF 169
Query: 180 I-VNAMASVEEVHEDIVALVKHEL 202
+ ++A S E V D A + L
Sbjct: 170 VRIDATQSPEAVIADAEAALADAL 193
>sp|P57434|KTHY_BUCAI THYMIDYLATE KINASE (DTMP KINASE) >gi|10039023|dbj|BAB13057.1|
(AP001119) thymidylate kinase [Buchnera sp. APS]
Length = 212
Score = 81.9 bits (199), Expect = 5e-15
Identities = 62/200 (31%), Positives = 105/200 (52%), Gaps = 8/200 (4%)
Query: 1 MRGYFVVLEGIDGSGKTTQAKLLAEWFEEQGW-DVLLTKEPTDTEFGRLIRELVLKNSII 59
++ F+V+EG++G+GKT + ++ +VLL ++P T IR L+ K
Sbjct: 2 IKSKFIVIEGLEGAGKTNACICIKNLLKKNSIKNVLLVRQPGSTPIAEDIRRLIKKK--F 59
Query: 60 DGSRISYEAEALLFAADRAEHVKKVILPALEKGKVVICDRYLYSSLAYQ-WARGLSLEWL 118
+ + E E LL A R + V+K I PAL+ G VI DR+ SSLAYQ G+ + +
Sbjct: 60 NDDNLIKETELLLMYAARIQLVEKKIKPALKNGIWVISDRHDLSSLAYQGGGLGIPKKII 119
Query: 119 MQINSFAPR---PDLAILLDLPVKESIRRTKARGNMSEFD-KLLELQRKVRMNYLKLAEM 174
Q+ S PDL I LD+ + + R R + + + L +K R YL+ +++
Sbjct: 120 YQLQSLFLNNFIPDLTIYLDVSPEIGLARALKRNPLDLIESRSLFFFKKTRRCYLEKSKL 179
Query: 175 FKEMRIVNAMASVEEVHEDI 194
K+ I+NA ++++V ++I
Sbjct: 180 DKKTIIINANLNIKKVTQNI 199
>gi|6322517 thymidylate kinase; Cdc8p [Saccharomyces cerevisiae]
>gi|1170719|sp|P00572|KTHY_YEAST THYMIDYLATE KINASE
(DTMP KINASE) >gi|2144430|pir||KIBYT8 dTMP kinase (EC
2.7.4.9) - yeast (Saccharomyces cerevisiae)
>gi|4558230|pdb|3TMK|A Chain A, Crystal Structure Of
Yeast Thymidylate Kinase Complexed With The Bisubstrate
Inhibitor Tp5a At 2.0 A Resolution: Implications For
Catalysis And Azt Activation >gi|4558231|pdb|3TMK|B
Chain B, Crystal Structure Of Yeast Thymidylate Kinase
Complexed With The Bisubstrate Inhibitor Tp5a At 2.0 A
Resolution: Implications For Catalysis And Azt
Activation >gi|4558235|pdb|3TMK|F Chain F, Crystal
Structure Of Yeast Thymidylate Kinase Complexed With The
Bisubstrate Inhibitor Tp5a At 2.0 A Resolution:
Implications For Catalysis And Azt Activation
>gi|4558234|pdb|3TMK|E Chain E, Crystal Structure Of
Yeast Thymidylate Kinase Complexed With The Bisubstrate
Inhibitor Tp5a At 2.0 A Resolution: Implications For
Catalysis And Azt Activation >gi|4558236|pdb|3TMK|G
Chain G, Crystal Structure Of Yeast Thymidylate Kinase
Complexed With The Bisubstrate Inhibitor Tp5a At 2.0 A
Resolution: Implications For Catalysis And Azt
Activation >gi|4558233|pdb|3TMK|D Chain D, Crystal
Structure Of Yeast Thymidylate Kinase Complexed With The
Bisubstrate Inhibitor Tp5a At 2.0 A Resolution:
Implications For Catalysis And Azt Activation
>gi|4558237|pdb|3TMK|H Chain H, Crystal Structure Of
Yeast Thymidylate Kinase Complexed With The Bisubstrate
Inhibitor Tp5a At 2.0 A Resolution: Implications For
Catalysis And Azt Activation >gi|4558232|pdb|3TMK|C
Chain C, Crystal Structure Of Yeast Thymidylate Kinase
Complexed With The Bisubstrate Inhibitor Tp5a At 2.0 A
Resolution: Implications For Catalysis And Azt
Activation >gi|3318847|pdb|1TMK|A Chain A, Yeast
Thymidylate Kinase Complexed With Thymidine
Monophosphate (Dtmp) >gi|3318848|pdb|1TMK|B Chain B,
Yeast Thymidylate Kinase Complexed With Thymidine
Monophosphate (Dtmp) >gi|3318768|pdb|2TMK|A Chain A,
Yeast Thymidylate Kinase Complexed With
3'-Azido-3'-Deoxythymidine Monophosphate (Azt-Mp)
>gi|3318769|pdb|2TMK|B Chain B, Yeast Thymidylate Kinase
Complexed With 3'-Azido-3'-Deoxythymidine Monophosphate
(Azt-Mp) >gi|172971|gb|AAB05644.1| (M15468) thymidylate
kinase [Saccharomyces cerevisiae]
>gi|1015725|emb|CAA89585.1| (Z49557) ORF YJR057w
[Saccharomyces cerevisiae] >gi|1019679|gb|AAB39283.1|
(L47993) ORF YJR057w [Saccharomyces cerevisiae]
Length = 216
Score = 79.6 bits (193), Expect = 3e-14
Identities = 59/181 (32%), Positives = 97/181 (52%), Gaps = 14/181 (7%)
Query: 2 RGYFVVLEGIDGSGKTTQAKLLAEWFEEQGWDVLLTKEPTDTEFGRLIRELVLKNSIIDG 61
RG +++EG+D +GKTTQ +L + + LL T G LI E + +S
Sbjct: 4 RGKLILIEGLDRTGKTTQCNILYKKLQPNC--KLLKFPERSTRIGGLINEYLTDDSF--- 58
Query: 62 SRISYEAEALLFAADRAEHVKKVILPALEKGKVVICDRYLYSSLAYQWAR---GLSLEWL 118
++S +A LLF+A+R E V K+ LE GK ++ DRY+YS +AY A+ G+ L+W
Sbjct: 59 -QLSDQAIHLLFSANRWEIVDKIKKDLLE-GKNIVMDRYVYSGVAYSAAKGTNGMDLDWC 116
Query: 119 MQINSFAPRPDLAILLDLPVKESIRRTKARGNMSEFDKLLELQRKVRMNYLKLAEMFKEM 178
+Q + +PDL + L ++ + G E + ++ Q KV+ ++KL + KE+
Sbjct: 117 LQPDVGLLKPDLTLFLS--TQDVDNNAEKSGFGDERYETVKFQEKVKQTFMKLLD--KEI 172
Query: 179 R 179
R
Sbjct: 173 R 173
>gb|AAA35158.1| (K02116) thymidylate kinase [Saccharomyces cerevisiae]
Length = 216
Score = 79.6 bits (193), Expect = 3e-14
Identities = 59/181 (32%), Positives = 97/181 (52%), Gaps = 14/181 (7%)
Query: 2 RGYFVVLEGIDGSGKTTQAKLLAEWFEEQGWDVLLTKEPTDTEFGRLIRELVLKNSIIDG 61
RG +++EG+D +GKTTQ +L + + LL T G LI E + +S
Sbjct: 4 RGKLILIEGLDRTGKTTQCNILYKKLQPNC--KLLKFPERSTRIGGLINEYLTDDSF--- 58
Query: 62 SRISYEAEALLFAADRAEHVKKVILPALEKGKVVICDRYLYSSLAYQWAR---GLSLEWL 118
++S +A LLF+A+R E V K+ LE GK ++ DRY+YS +AY A+ G+ L+W
Sbjct: 59 -QLSDQAIHLLFSANRWEIVDKIKKDLLE-GKNIVMDRYVYSGVAYSAAKGTNGMDLDWC 116
Query: 119 MQINSFAPRPDLAILLDLPVKESIRRTKARGNMSEFDKLLELQRKVRMNYLKLAEMFKEM 178
+Q + +PDL + L ++ + G E + ++ Q KV+ ++KL + KE+
Sbjct: 117 LQPDVGLLKPDLTLFLS--TQDVDNNAEKSGFGDERYETVKFQEKVKQTFMKLLD--KEI 172
Query: 179 R 179
R
Sbjct: 173 R 173
>gb|AAA34486.1| (K01783) CDC8 gene [Saccharomyces cerevisiae]
Length = 216
Score = 78.4 bits (190), Expect = 6e-14
Identities = 58/181 (32%), Positives = 97/181 (53%), Gaps = 14/181 (7%)
Query: 2 RGYFVVLEGIDGSGKTTQAKLLAEWFEEQGWDVLLTKEPTDTEFGRLIRELVLKNSIIDG 61
RG +++EG+D +GKTTQ +L + + LL T G LI E + ++
Sbjct: 4 RGKLILIEGLDRTGKTTQCNILYKKLQPNC--KLLKFPERSTRIGGLINEYLTDDTF--- 58
Query: 62 SRISYEAEALLFAADRAEHVKKVILPALEKGKVVICDRYLYSSLAYQWAR---GLSLEWL 118
++S +A LLF+A+R E V K+ LE GK ++ DRY+YS +AY A+ G+ L+W
Sbjct: 59 -QLSDQAIHLLFSANRWEIVDKIKKDLLE-GKNIVMDRYVYSGVAYSAAKGTNGMDLDWC 116
Query: 119 MQINSFAPRPDLAILLDLPVKESIRRTKARGNMSEFDKLLELQRKVRMNYLKLAEMFKEM 178
+Q + +PDL + L ++ + G E + ++ Q KV+ ++KL + KE+
Sbjct: 117 LQPDVGLLKPDLTLFLS--TQDVDNNAEKSGFGDERYETVKFQEKVKQTFMKLLD--KEI 172
Query: 179 R 179
R
Sbjct: 173 R 173
>emb|CAB58191.1| (AJ270426) thymidylate kinase [Yersinia enterocolitica]
>gi|6066872|emb|CAB58193.1| (AJ270428) thymidylate
kinase [Yersinia enterocolitica]
Length = 165
Score = 78.4 bits (190), Expect = 6e-14
Identities = 51/145 (35%), Positives = 78/145 (53%), Gaps = 7/145 (4%)
Query: 33 DVLLTKEPTDTEFGRLIRELVLKNSIIDGSRISYEAEALLFAADRAEHVKKVILPALEKG 92
D++ T+EP T +R+L+ + IDG ++ +AE L+ A R + V+ VI PAL +G
Sbjct: 16 DIVFTREPGGTPLAEKLRDLIKQG--IDGEVLTDKAEVLMLYAARVQLVENVIKPALARG 73
Query: 93 KVVICDRYLYSSLAYQ-WARGLSLEWLMQINSFAP---RPDLAILLDLPVKESIRRTKAR 148
V+ DR+ SS AYQ RG+ + + + RPDL + LDLP + R +AR
Sbjct: 74 SWVVGDRHDLSSQAYQGGGRGIDINLMTSLRDTVLGEFRPDLTLYLDLPPVIGLARARAR 133
Query: 149 GNMSEFD-KLLELQRKVRMNYLKLA 172
G + + + L + R YLKLA
Sbjct: 134 GELDRIEQESLAFFERTRERYLKLA 158
>emb|CAB58204.1| (AJ270417) thymidylate kinase [Yersinia pestis]
Length = 165
Score = 77.3 bits (187), Expect = 1e-13
Identities = 50/145 (34%), Positives = 78/145 (53%), Gaps = 7/145 (4%)
Query: 33 DVLLTKEPTDTEFGRLIRELVLKNSIIDGSRISYEAEALLFAADRAEHVKKVILPALEKG 92
D++ T+EP T +R+L+ + IDG ++ +AE L+ A R + V+ VI PAL +G
Sbjct: 16 DIVFTREPGGTPLAEKLRDLIKQG--IDGEVLTDKAEVLMLYAARVQLVENVIKPALARG 73
Query: 93 KVVICDRYLYSSLAYQ-WARGLSLEWLMQINSFAP---RPDLAILLDLPVKESIRRTKAR 148
V+ DR+ SS AYQ RG+ + + + RPDL + LDLP + R +AR
Sbjct: 74 SWVVGDRHDLSSQAYQGGGRGIDSQLMASLRDTVLGEFRPDLTLYLDLPPAVGLARARAR 133
Query: 149 GNMSEFD-KLLELQRKVRMNYLKLA 172
G + + + L + R YL+LA
Sbjct: 134 GELDRIEQESLAFFERTRARYLELA 158
>emb|CAB58225.1| (AJ270418) thymidylate kinase [Yersinia pseudotuberculosis]
>gi|6066854|emb|CAB58210.1| (AJ270419) thymidylate
kinase [Yersinia pseudotuberculosis]
>gi|6066856|emb|CAB58211.1| (AJ270420) thymidylate
kinase [Yersinia pseudotuberculosis]
>gi|6066858|emb|CAB58212.1| (AJ270421) thymidylate
kinase [Yersinia pseudotuberculosis]
Length = 165
Score = 77.3 bits (187), Expect = 1e-13
Identities = 50/145 (34%), Positives = 78/145 (53%), Gaps = 7/145 (4%)
Query: 33 DVLLTKEPTDTEFGRLIRELVLKNSIIDGSRISYEAEALLFAADRAEHVKKVILPALEKG 92
D++ T+EP T +R+L+ + IDG ++ +AE L+ A R + V+ VI PAL +G
Sbjct: 16 DIVFTREPGGTPLAEKLRDLIKQG--IDGEVLTDKAEVLMLYAARVQLVENVIKPALARG 73
Query: 93 KVVICDRYLYSSLAYQ-WARGLSLEWLMQINSFAP---RPDLAILLDLPVKESIRRTKAR 148
V+ DR+ SS AYQ RG+ + + + RPDL + LDLP + R +AR
Sbjct: 74 SWVVGDRHDLSSQAYQGGGRGIDSQLMASLRDTVLGEFRPDLTLYLDLPPAVGLARARAR 133
Query: 149 GNMSEFD-KLLELQRKVRMNYLKLA 172
G + + + L + R YL+LA
Sbjct: 134 GELDRIEQESLAFFERTRARYLELA 158
>emb|CAB58213.1| (AJ270422) thymidylate kinase [Yersinia pseudotuberculosis]
Length = 165
Score = 77.3 bits (187), Expect = 1e-13
Identities = 50/145 (34%), Positives = 78/145 (53%), Gaps = 7/145 (4%)
Query: 33 DVLLTKEPTDTEFGRLIRELVLKNSIIDGSRISYEAEALLFAADRAEHVKKVILPALEKG 92
D++ T+EP T +R+L+ + IDG ++ +AE L+ A R + V+ VI PAL +G
Sbjct: 16 DIVFTREPGGTPLAEKLRDLIKQG--IDGEVLTDKAEVLMLYAARVQLVENVIKPALARG 73
Query: 93 KVVICDRYLYSSLAYQ-WARGLSLEWLMQINSFAP---RPDLAILLDLPVKESIRRTKAR 148
V+ DR+ SS AYQ RG+ + + + RPDL + LDLP + R +AR
Sbjct: 74 SWVVGDRHDLSSQAYQGGGRGIDSQLMASLRDTVLGEFRPDLTLYLDLPPAVGLARARAR 133
Query: 149 GNMSEFD-KLLELQRKVRMNYLKLA 172
G + + + L + R YL+LA
Sbjct: 134 GELDRIEQESLAFFERTRARYLELA 158
>emb|CAB58188.1| (AJ270423) thymidylate kinase [Yersinia enterocolitica]
>gi|6066864|emb|CAB58189.1| (AJ270424) thymidylate
kinase [Yersinia enterocolitica]
>gi|6066866|emb|CAB58190.1| (AJ270425) thymidylate
kinase [Yersinia enterocolitica]
Length = 165
Score = 77.3 bits (187), Expect = 1e-13
Identities = 50/145 (34%), Positives = 78/145 (53%), Gaps = 7/145 (4%)
Query: 33 DVLLTKEPTDTEFGRLIRELVLKNSIIDGSRISYEAEALLFAADRAEHVKKVILPALEKG 92
D++ T+EP T +R+L+ + IDG ++ +AE L+ A R + V+ VI PAL +G
Sbjct: 16 DIVFTREPGGTPLAEKLRDLIKQG--IDGEVLTDKAEVLMLYAARVQLVENVIKPALARG 73
Query: 93 KVVICDRYLYSSLAYQ-WARGLSLEWLMQINSFAP---RPDLAILLDLPVKESIRRTKAR 148
V+ DR+ SS AYQ RG+ + + + RPDL + LDLP + R +AR
Sbjct: 74 SWVVGDRHDLSSQAYQGGGRGIDINLMTSLRDTVLGEFRPDLTLYLDLPPAIGLARARAR 133
Query: 149 GNMSEFD-KLLELQRKVRMNYLKLA 172
G + + + L + R YL+LA
Sbjct: 134 GELDRIEQESLAFFERTRERYLELA 158
>emb|CAB58192.1| (AJ270427) thymidylate kinase [Yersinia enterocolitica]
>gi|6066874|emb|CAB58194.1| (AJ270429) thymidylate
kinase [Yersinia enterocolitica]
Length = 165
Score = 76.9 bits (186), Expect = 2e-13
Identities = 50/145 (34%), Positives = 78/145 (53%), Gaps = 7/145 (4%)
Query: 33 DVLLTKEPTDTEFGRLIRELVLKNSIIDGSRISYEAEALLFAADRAEHVKKVILPALEKG 92
D++ T+EP T +R+L+ + IDG ++ +AE L+ A R + V+ VI PAL +G
Sbjct: 16 DIVFTREPGGTPLAEKLRDLIKQG--IDGEVLTDKAEVLMLYAARVQLVENVIKPALARG 73
Query: 93 KVVICDRYLYSSLAYQ-WARGLSLEWLMQINSFAP---RPDLAILLDLPVKESIRRTKAR 148
V+ DR+ SS AYQ RG+ + + + RPDL + LDLP + R +AR
Sbjct: 74 SWVVGDRHDLSSQAYQGGGRGIDINLMTSLRDTVLGEFRPDLTLYLDLPPVIGLARARAR 133
Query: 149 GNMSEFD-KLLELQRKVRMNYLKLA 172
G + + + L + R YL+LA
Sbjct: 134 GELDRIEQESLAFFERTRERYLELA 158
>pir||F81347 probable dTMP kinase (EC 2.7.4.9) Cj0766c [imported] -
Campylobacter jejuni (strain NCTC 11168)
>gi|6968212|emb|CAB73031.1| (AL139076) putative
thymidylate kinase [Campylobacter jejuni]
Length = 192
Score = 76.5 bits (185), Expect = 2e-13
Identities = 65/203 (32%), Positives = 104/203 (51%), Gaps = 30/203 (14%)
Query: 5 FVVLEGIDGSGKTTQAKLLAEWFEEQGWDVLLTKEPTDTEFGRLIRELVLKNSIIDGSRI 64
+VV EGID GK+TQ LL E ++ D + T EP TE G+ +RE++L + I
Sbjct: 2 YVVFEGIDCVGKSTQISLLKEIYK----DAIFTLEPGGTELGKHLREILLNKT----HPI 53
Query: 65 SYEAEALLFAADRAEHVKKVILPALEKGKVVICDRYLYSSLAYQWARGLSLEWLMQINSF 124
+ AE LLF ADRA+H ++++ + K++I DR S +AY A+ + L +NSF
Sbjct: 54 NKRAELLLFLADRAQHFEEIL--KTNQNKLIISDRSFISGMAY--AKDFENDLLFALNSF 109
Query: 125 APR---PDLAILLDLPVKESIRRTKARGNMSEFDKL--------LELQRKVR--MNYLKL 171
A P I L K + R + E D + L +Q K+ +++LK
Sbjct: 110 ALENFFPQKIIFL----KGDANLIQERLSQKELDSIEKRGIEYFLSVQDKLEKVLHFLK- 164
Query: 172 AEMFKEMRIVNAMASVEEVHEDI 194
++ E+ ++A S E++H+ I
Sbjct: 165 EKISVEILTLDAKESKEKLHQQI 187
>sp|Q22018|KTHY_CAEEL PROBABLE THYMIDYLATE KINASE (DTMP KINASE) >gi|7506780|pir||T24244
hypothetical protein R53.2 - Caenorhabditis elegans
>gi|3879168|emb|CAA91347.1| (Z66515) contains similarity
to Pfam domain: PF02223 (Thymidylate kinase),
Score=250.1, E-value=1e-71, N=1~cDNA EST EMBL:T00891
comes from this gene~cDNA EST yk115f8.3 comes from this
gene~cDNA EST EMBL:D73052 comes from this gene~cDNA EST
yk115f8.5 co>
Length = 218
Score = 76.1 bits (184), Expect = 3e-13
Identities = 50/153 (32%), Positives = 77/153 (49%), Gaps = 16/153 (10%)
Query: 2 RGYFVVLEGIDGSGKTTQAKLLAEWFEEQGWD----------VLLTKEPTDTEFGRLIRE 51
RG +V EG+D SGK+TQAK L E ++ + VL + G+LI +
Sbjct: 7 RGLLIVFEGLDRSGKSTQAKRLVESINKKSTESGDASSSPSAVLQAFPDRSSSIGKLIDQ 66
Query: 52 LVLKNSIIDGSRISYEAEALLFAADRAEHVKKVILPALEKGKVVICDRYLYSSLAYQWAR 111
+ K +D + LLF+ADR ++I + KG VICDRY YS +AY A+
Sbjct: 67 YLRKEIDMDEHALH-----LLFSADRFSK-NQMIRDNIAKGIDVICDRYCYSGVAYSLAK 120
Query: 112 GLSLEWLMQINSFAPRPDLAILLDLPVKESIRR 144
GL +W+ + P+PD + D+ + + +R
Sbjct: 121 GLPEQWVRSSDVGLPKPDAVLFFDVSPEVAAQR 153
>emb|CAC11229.1| (AL445063) conserved hypothetical protein [Thermoplasma
acidophilum]
Length = 193
Score = 74.1 bits (179), Expect = 1e-12
Identities = 63/211 (29%), Positives = 104/211 (48%), Gaps = 35/211 (16%)
Query: 5 FVVLEGIDGSGKTTQAKLLAEWFEEQGWDVLLTKEPTDTEFGRLIRELVLKNSIIDGSRI 64
F+ +EGIDG+GKTT A+ + +G+ V +TKEPTD ++N DG +
Sbjct: 2 FIAIEGIDGAGKTTLARGIGNMLLGEGYRVYMTKEPTDG----------MENYAGDGVEL 51
Query: 65 SYEAEALLFAADRAEHVKKVILPALEKGKVVICDRYLYSSLAYQWARGL---------SL 115
L F +R H ++ I ++ G++VICDRY+ SS AYQ+ G+ +
Sbjct: 52 -----FLKFTINRYAH-QREIDRHIKNGEIVICDRYIRSSYAYQF-EGIAEFFGNSEKAW 104
Query: 116 EWLMQINSFAP-RPDLAILLDLPVKESIRRTKARGNMSEFDKLLELQRKVRMNYLKLAEM 174
EW+ ++ RPD+ I +D+ + ++ R RG + + + R VR Y +
Sbjct: 105 EWMDSVSEIIKIRPDVQIYVDVDEETAMERISRRGLRNPHFENEQKLRSVRQIY----KG 160
Query: 175 FKEMRIVNA----MASVEEVHEDIVALVKHE 201
F+ IV+ A + E E I+A ++ E
Sbjct: 161 FQWDLIVDGGRDKEAIISETFEKIIARLRQE 191
>sp|P36590|KTHY_SCHPO THYMIDYLATE KINASE (DTMP KINASE) >gi|478751|pir||S28955 dTMP kinase
(EC 2.7.4.9) - fission yeast (Schizosaccharomyces
pombe) >gi|4974|emb|CAA46698.1| (X65868) thymidylate
kinase [Schizosaccharomyces pombe]
Length = 210
Score = 73.4 bits (177), Expect = 2e-12
Identities = 64/205 (31%), Positives = 103/205 (50%), Gaps = 16/205 (7%)
Query: 2 RGYFVVLEGIDGSGKTTQAKLLAEWFEEQGWDVLLTKEPT-DTEFGRLIRELVLKNSIID 60
RG +V+EG+D SGK+TQ +LL + + L K P T G+ I + + ++ ++
Sbjct: 6 RGRLIVIEGLDRSGKSTQCQLLVDKLILNMKRLKLFKFPDRTTAIGKKIDDYLTESVQLN 65
Query: 61 GSRISYEAEALLFAADRAEHVKKVILPALEKGKVVICDRYLYSSLAYQWARGLSLEWLMQ 120
I LLF+A+R E + A ++ I DRY +S +A+ A+GL EW
Sbjct: 66 DQVIH-----LLFSANRWE--PSIYYRANQQRCNCILDRYAFSGIAFSAAKGLDWEWCKS 118
Query: 121 INSFAPRPDLAILLDLPVKESIRRTKARGNMSEFDKLLELQRKVRMNYLKLAEMFKE--M 178
+ RPDL I L+ V I T+ + ++K +E+Q KV N +L + F+E +
Sbjct: 119 PDRGLTRPDLVIFLN--VDPRIAATRGQYGEERYEK-IEMQEKVLKNLQRLQKEFREEGL 175
Query: 179 RIVNAMAS---VEEVHEDIVALVKH 200
+ AS +E+V IV LV +
Sbjct: 176 EFITLDASSYALEDVDSQIVDLVSN 200
>sp|P97930|KTHY_MOUSE THYMIDYLATE KINASE (DTMP KINASE) >gi|1836042|gb|AAB46838.1|
(S82853) thymidylate kinase, TMK=catalyzes theconvertion
of dTMP to dTDP [mice, BALB/c, 3T3 cells, Peptide, 227
aa] [Mus sp.]
Length = 227
Score = 71.0 bits (171), Expect = 1e-11
Identities = 48/145 (33%), Positives = 76/145 (52%), Gaps = 8/145 (5%)
Query: 2 RGYFVVLEGIDGSGKTTQAKLLAEWFEEQGWDVLLTKEP-TDTEFGRLIRELVLKNSIID 60
RG +VLEG+D +GKTTQ L G L + P TE G+L+ + K + ++
Sbjct: 5 RGALIVLEGVDRAGKTTQGLKLVTALCASGHRAELLRFPERSTEIGKLLNSYLEKKTELE 64
Query: 61 GSRISYEAEALLFAADRAEHVKKVILPALEKGKVVICDRYLYSSLAYQWAR-GLSLEWLM 119
+ LLF+A+R E V +I L +G ++ DRY +S +A+ A+ SL+W
Sbjct: 65 DHSVH-----LLFSANRWEQV-PLIKAKLNQGVTLVLDRYAFSGVAFTGAKENFSLDWCK 118
Query: 120 QINSFAPRPDLAILLDLPVKESIRR 144
Q + P+PDL + L L + ++ R
Sbjct: 119 QPDVGLPKPDLILFLQLQLLDAAAR 143
>pir||S48605 hypothetical protein - Mycoplasma capricolum (fragment)
>gi|950071|emb|CAA83746.1| (Z33079) ATP-bind.
pyrimidine kinase [Mycoplasma capricolum]
Length = 98
Score = 69.1 bits (166), Expect = 4e-11
Identities = 40/93 (43%), Positives = 54/93 (58%), Gaps = 5/93 (5%)
Query: 5 FVVLEGIDGSGKTTQAKLLAEWFEEQGWDVLLTKEPTDTEFGRLIRELVLKNSIIDGSRI 64
F+ EG+DGSGKTT + E E + VL+T+EP IR+++L N D +
Sbjct: 2 FITFEGMDGSGKTTALLKVKEELERLNYKVLITREPGGEVIAEQIRQIILDNKNKD---M 58
Query: 65 SYEAEALLFAADRAEHVKKVILPALEKGKVVIC 97
EALLF A R +H++KVI PALEK +IC
Sbjct: 59 DAWTEALLFIASRNQHLQKVIKPALEKN--IIC 89
>pir||H70198 thymidylate kinase (tmk) homolog - Lyme disease spirochete
>gi|2688733|gb|AAC67140.1| (AE001178) thymidylate kinase
(tmk) [Borrelia burgdorferi]
Length = 257
Score = 67.9 bits (163), Expect = 8e-11
Identities = 54/193 (27%), Positives = 100/193 (50%), Gaps = 21/193 (10%)
Query: 5 FVVLEGIDGSGKTTQAKLLAEWFEEQGWDVLLTKEPTDTEFGRLIRELVLK-NSIIDGSR 63
F +EGIDGSGKT+ L ++ TKEP+ G +IR+ ++ + ++ S
Sbjct: 63 FYCIEGIDGSGKTSITNKLKALCNDES-RYYFTKEPSSGIIGEMIRKQLMNFENPLEEST 121
Query: 64 ISYEAEALLFAADRAEHVKKV--ILPALE-KGKVVICDRYLYSSLAYQWARGLSLEWLMQ 120
+Y L+AADR +H+ K IL L K + +I DRYL+SS+AYQ G +
Sbjct: 122 FAY-----LYAADRHDHLYKKGGILEILNTKSRKIITDRYLFSSIAYQGKLG------YE 170
Query: 121 INSFAPRPDLAILLDLP---VKESIRRTKARGNMSEFDKLLELQRKVRMNYLKL-AEMFK 176
+N P P+ ++ E I++ + + ++ E +K + ++ + YLK+ ++ K
Sbjct: 171 LNKNFPLPEKVFFIETDPNIAYERIQKNRTQSDLFELEKYKTFE-QIALKYLKIFKKLEK 229
Query: 177 EMRIVNAMASVEE 189
++ ++ S+++
Sbjct: 230 KINVIYINNSIKD 242
Database: ./suso.pep
Posted date: Jul 6, 2001 5:57 PM
Number of letters in database: 840,471
Number of sequences in database: 2977
Database: /banques/blast2/nr.pep
Posted date: Dec 14, 2000 12:46 PM
Number of letters in database: 188,266,275
Number of sequences in database: 595,510
Lambda K H
0.321 0.138 0.392
Gapped
Lambda K H
0.270 0.0470 0.230
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 69917478
Number of Sequences: 2977
Number of extensions: 2622098
Number of successful extensions: 10655
Number of sequences better than 1.0e-10: 62
Number of HSP's better than 0.0 without gapping: 3
Number of HSP's successfully gapped in prelim test: 59
Number of HSP's that attempted gapping in prelim test: 10527
Number of HSP's gapped (non-prelim): 62
length of query: 205
length of database: 189,106,746
effective HSP length: 55
effective length of query: 150
effective length of database: 156,189,961
effective search space: 23428494150
effective search space used: 23428494150
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 41 (21.8 bits)
S2: 163 (67.9 bits)