BLASTP 2.0.10 [Aug-26-1999]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= PAB0372 (mvk) DE:mevalonate kinase (mvk)
(335 letters)
Database: ./suso.pep; /banques/blast2/nr.pep
598,487 sequences; 189,106,746 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9V187|KIME_PYRAB MEVALONATE KINASE (MK) >gi|7519971|pir||H75... 647 0.0
sp|O59291|KIME_PYRHO MEVALONATE KINASE (MK) >gi|7521211|pir||A71... 596 e-169
gb|AAG19529.1| (AE005044) mevalonate kinase; Mvk [Halobacterium ... 199 4e-50
sp|Q50559|KIME_METTH MEVALONATE KINASE (MK) >gi|1184118|gb|AAA87... 189 3e-47
pir||B69160 mevalonate kinase - Methanobacterium thermoautotroph... 187 1e-46
gb|AAK40711.1| Mevalonate kinase [Sulfolobus solfataricus] 171 7e-42
gi|11499870 mevalonate kinase (mvk) [Archaeoglobus fulgidus] >gi... 168 1e-40
sp|Q58487|KIME_METJA MEVALONATE KINASE (MK) >gi|2129120|pir||F64... 146 3e-34
gi|4557769 mevalonate kinase [Homo sapiens] >gi|417215|sp|Q03426... 133 3e-30
emb|CAA53059.1| (X75311) ORF for viral-cellular fusion transcrip... 133 3e-30
gi|11436567 mevalonate kinase [Homo sapiens] 133 3e-30
gb|AAG02445.1|AF290095_1 (AF290095) mevalonate kinase [Enterococ... 132 5e-30
sp|P17256|KIME_RAT MEVALONATE KINASE (MK) >gi|111959|pir||A35629... 131 1e-29
sp|Q9Y946|KIME_AERPE MEVALONATE KINASE (MK) >gi|7521212|pir||F72... 131 2e-29
sp|Q9R008|KIME_MOUSE MEVALONATE KINASE (MK) >gi|6006984|gb|AAF00... 127 2e-28
gb|AAG02424.1|AF290087_1 (AF290087) mevalonate kinase [Staphyloc... 126 4e-28
gb|AAG02440.1|AF290093_1 (AF290093) mevalonate kinase [Enterococ... 126 4e-28
sp|Q09780|KIME_SCHPO PUTATIVE MEVALONATE KINASE (MK) >gi|2117774... 126 4e-28
gi|6323864 mevalonate kinase; Erg12p [Saccharomyces cerevisiae] ... 125 7e-28
gb|AAD45421.1|L77688_1 (L77688) mevalonate kinase [Arabidopsis t... 125 9e-28
sp|P46086|KIME_ARATH MEVALONATE KINASE (MK) >gi|541880|pir||S420... 123 3e-27
dbj|BAB07817.1| (AB037907) mevalonate kinase [Streptomyces grise... 123 3e-27
gb|AAF58481.1| (AE003821) CG16804 gene product [Drosophila melan... 121 1e-26
gb|AAG02435.1|AF290091_1 (AF290091) mevalonate kinase [Staphyloc... 115 6e-25
dbj|BAB07790.1| (AB037666) mevalonate kinase [Streptomyces sp. C... 112 5e-24
gb|AAG02450.1|AF290097_1 (AF290097) mevalonate kinase [Streptoco... 110 3e-23
gb|AAG02430.1|AF290089_1 (AF290089) mevalonate kinase [Staphyloc... 108 1e-22
gb|AAG02455.1|AF290099_1 (AF290099) mevalonate kinase [Streptoco... 93 5e-18
gb|AAG28454.1|AF195244_1 (AF195244) galactokinase [Pyrococcus fu... 91 1e-17
sp|Q9RGS1|GAL1_STACA GALACTOKINASE (GALACTOSE KINASE) >gi|670700... 84 2e-15
dbj|BAB07819.1| (AB037907) phosphomevalonate kinase [Streptomyce... 82 7e-15
sp|O58107|GAL1_PYRHO PROBABLE GALACTOKINASE (GALACTOSE KINASE) >... 80 3e-14
sp|O85253|GAL1_THENE GALACTOKINASE (GALACTOSE KINASE) >gi|325290... 75 1e-12
pir||G70185 mevalonate kinase homolog - Lyme disease spirochete ... 74 3e-12
gb|AAK43093.1| (Phospho) mevalonate kinase, putative [Sulfolobus... 73 6e-12
sp|P56838|GAL1_THEMA GALACTOKINASE >gi|7434204|pir||C72283 galac... 72 8e-12
gb|AAG02447.1|AF290095_3 (AF290095) phosphomevalonate kinase [En... 72 8e-12
gb|AAG02426.1|AF290087_3 (AF290087) phosphomevalonate kinase [St... 71 1e-11
gb|AAG02437.1|AF290091_3 (AF290091) phosphomevalonate kinase [St... 70 3e-11
gb|AAG02432.1|AF290089_3 (AF290089) phosphomevalonate kinase [St... 69 5e-11
>sp|Q9V187|KIME_PYRAB MEVALONATE KINASE (MK) >gi|7519971|pir||H75172 mevalonate kinase
(mvk) PAB0372 - Pyrococcus abyssi (strain Orsay)
>gi|5457973|emb|CAB49463.1| (AJ248284) mevalonate kinase
(mvk) [Pyrococcus abyssi]
Length = 335
Score = 647 bits (1650), Expect = 0.0
Identities = 335/335 (100%), Positives = 335/335 (100%)
Query: 1 MPRLVLASAPAKIILFGEHSVVYGKPAIASAIDLRTYVRAEFNDSGNIKIEAHDIKTPGL 60
MPRLVLASAPAKIILFGEHSVVYGKPAIASAIDLRTYVRAEFNDSGNIKIEAHDIKTPGL
Sbjct: 1 MPRLVLASAPAKIILFGEHSVVYGKPAIASAIDLRTYVRAEFNDSGNIKIEAHDIKTPGL 60
Query: 61 IVSFSEDKIYFETDYGKAAEVLSYVRHAIELVLEEADKRTGVSVSITSQIPVGAGLGSSA 120
IVSFSEDKIYFETDYGKAAEVLSYVRHAIELVLEEADKRTGVSVSITSQIPVGAGLGSSA
Sbjct: 61 IVSFSEDKIYFETDYGKAAEVLSYVRHAIELVLEEADKRTGVSVSITSQIPVGAGLGSSA 120
Query: 121 AVAVATIGAVSKLLDLELSKEEIAKMGHKVELLVQGASSGIDPTVSAIGGFLYYKQGEFE 180
AVAVATIGAVSKLLDLELSKEEIAKMGHKVELLVQGASSGIDPTVSAIGGFLYYKQGEFE
Sbjct: 121 AVAVATIGAVSKLLDLELSKEEIAKMGHKVELLVQGASSGIDPTVSAIGGFLYYKQGEFE 180
Query: 181 HLPFVELPIVVGYTGSSGSTKELVAMVRRRYEEMPELIEPILESMGKLVDKAKEVIISKL 240
HLPFVELPIVVGYTGSSGSTKELVAMVRRRYEEMPELIEPILESMGKLVDKAKEVIISKL
Sbjct: 181 HLPFVELPIVVGYTGSSGSTKELVAMVRRRYEEMPELIEPILESMGKLVDKAKEVIISKL 240
Query: 241 DEEEKFLKLGELMNINHGLLDALGVSTKKLSELVYAARTAGAIGAKLTGAGGGGCMYALA 300
DEEEKFLKLGELMNINHGLLDALGVSTKKLSELVYAARTAGAIGAKLTGAGGGGCMYALA
Sbjct: 241 DEEEKFLKLGELMNINHGLLDALGVSTKKLSELVYAARTAGAIGAKLTGAGGGGCMYALA 300
Query: 301 PGKQREVATAIKIAGGTPMITRISKEGLRIEEVRE 335
PGKQREVATAIKIAGGTPMITRISKEGLRIEEVRE
Sbjct: 301 PGKQREVATAIKIAGGTPMITRISKEGLRIEEVRE 335
>sp|O59291|KIME_PYRHO MEVALONATE KINASE (MK) >gi|7521211|pir||A71042 probable mevalonate
kinase - Pyrococcus horikoshii
>gi|3258054|dbj|BAA30737.1| (AP000006) 335aa long
hypothetical mevalonate kinase [Pyrococcus horikoshii]
Length = 335
Score = 596 bits (1520), Expect = e-169
Identities = 301/333 (90%), Positives = 322/333 (96%)
Query: 1 MPRLVLASAPAKIILFGEHSVVYGKPAIASAIDLRTYVRAEFNDSGNIKIEAHDIKTPGL 60
M + VLASAPAK+ILFGEHSVVYGKPAIASAI+LRTYVRA+FNDSGNIKIEAHDIKTPGL
Sbjct: 1 MVKYVLASAPAKVILFGEHSVVYGKPAIASAIELRTYVRAQFNDSGNIKIEAHDIKTPGL 60
Query: 61 IVSFSEDKIYFETDYGKAAEVLSYVRHAIELVLEEADKRTGVSVSITSQIPVGAGLGSSA 120
IVSFSEDKIYFETDYGKAAEVLSYVR+AIEL LEE+DKR G+ VSITSQIPVGAGLGSSA
Sbjct: 61 IVSFSEDKIYFETDYGKAAEVLSYVRYAIELALEESDKRVGIDVSITSQIPVGAGLGSSA 120
Query: 121 AVAVATIGAVSKLLDLELSKEEIAKMGHKVELLVQGASSGIDPTVSAIGGFLYYKQGEFE 180
AVAVATIGAVS+LL LELSKEEIAK+GHKVELLVQGASSGIDPTVSA+GGFLYYKQG+FE
Sbjct: 121 AVAVATIGAVSRLLGLELSKEEIAKLGHKVELLVQGASSGIDPTVSAVGGFLYYKQGKFE 180
Query: 181 HLPFVELPIVVGYTGSSGSTKELVAMVRRRYEEMPELIEPILESMGKLVDKAKEVIISKL 240
LPF+ELPIVVGYTGS+GSTKELVAMVR+RYEEMPEL+EPILE+MGKLVDKAKE+I+SKL
Sbjct: 181 PLPFMELPIVVGYTGSTGSTKELVAMVRKRYEEMPELVEPILEAMGKLVDKAKEIILSKL 240
Query: 241 DEEEKFLKLGELMNINHGLLDALGVSTKKLSELVYAARTAGAIGAKLTGAGGGGCMYALA 300
DEEEK KLGELMNINHGLLDALGVSTKKL ELVYAARTAGAIGAKLTGAGGGGCMYALA
Sbjct: 241 DEEEKLTKLGELMNINHGLLDALGVSTKKLGELVYAARTAGAIGAKLTGAGGGGCMYALA 300
Query: 301 PGKQREVATAIKIAGGTPMITRISKEGLRIEEV 333
PG+QREVATAIKIAGG PMITR+S+EGLRIEEV
Sbjct: 301 PGRQREVATAIKIAGGIPMITRVSREGLRIEEV 333
>gb|AAG19529.1| (AE005044) mevalonate kinase; Mvk [Halobacterium sp. NRC-1]
Length = 330
Score = 199 bits (501), Expect = 4e-50
Identities = 131/337 (38%), Positives = 185/337 (54%), Gaps = 23/337 (6%)
Query: 7 ASAPAKIILFGEHSVVYGKPAIASAIDLRTYVRAEFNDSGNIKIEAHDIKTPGLIVSFSE 66
+SAP K+ LFGEH+VVYG+PA+ AI+ R +V + +++ + D+ G V +S
Sbjct: 5 SSAPGKVYLFGEHAVVYGEPAVPCAIERRAHVTVSEREDSRLRVCSGDLSIDGFTVEYSG 64
Query: 67 DKIYFETDYGKAAEV----------LSYVRHAIELVLEEADKRT-GVSVSITSQIPVGAG 115
D+ D G +V + YV A+E AD T G V+I S+IP+GAG
Sbjct: 65 DR-----DAGGTPDVDVPAPIVDAAMGYVDAAVEQARAAADAPTAGFDVTIDSEIPLGAG 119
Query: 116 LGSSAAVAVATIGAVSKLLDLELSKEEIAKMGHKVELLVQ-GASSGIDPTVSAIGGFLYY 174
LGSSAAV VA I A ++ L +EL E+A ++VE VQ G +S D SA+GG +
Sbjct: 120 LGSSAAVVVAGIDAATRELGVELDAREVADRAYQVEHTVQDGEASRADTFCSAMGGVVRV 179
Query: 175 KQGEFEHLPFVELPIVVGYTGSSGSTKELVAMVRRRYEEMPELIEPILESMGKLVDKAKE 234
+ L LP V+GY G+S T ELVA VR EE + + + ++G LV + +
Sbjct: 180 SGDDCTTLDAPALPFVIGYDGTSHDTGELVAGVRALREEFGFVADTVT-AIGDLVRRGEA 238
Query: 235 VIISKLDEEEKFLKLGELMNINHGLLDALGVSTKKLSELVYAARTAGAIGAKLTGAGGGG 294
+ + LG LM+INHGLL LGVS + L +V+AAR GA GAKLTGAGGGG
Sbjct: 239 ALA-----DGDVATLGRLMDINHGLLSGLGVSGRTLDAMVWAARDGGADGAKLTGAGGGG 293
Query: 295 CMYALAPGKQREVATAIKIAGGTPMITRISKEGLRIE 331
+ AL G E A ++ +++EG+R+E
Sbjct: 294 SIVALDAGSGAETALSLTPDCEAAFRADLAREGVRVE 330
>sp|Q50559|KIME_METTH MEVALONATE KINASE (MK) >gi|1184118|gb|AAA87051.1| (U47134)
mevalonate kinase [Methanobacterium thermoautotrophicum]
Length = 303
Score = 189 bits (476), Expect = 3e-47
Identities = 116/306 (37%), Positives = 173/306 (55%), Gaps = 25/306 (8%)
Query: 7 ASAPAKIILFGEHSVVYGKPAIASAIDLRTYVRAEFNDSGNIKIEAHDIKTPGLIVSFSE 66
ASAPAK ILFGEH+VVY KPAIA+AID R V + S ++ I P L + S
Sbjct: 5 ASAPAKAILFGEHAVVYSKPAIAAAIDRRVTVTVSESSSTHVTI-------PSLGIRHSS 57
Query: 67 DKIYFETDYGKAAEVLSYVRHAIELVLEEADKRTGVSVSITSQIPVGAGLGSSAAVAVAT 126
++ + +L Y+ +EL + + + + + +IP G+GLGSSAA+ VA
Sbjct: 58 ER--------PSGGILDYIGRCLELYHDASP----LDIRVEMEIPAGSGLGSSAALTVAL 105
Query: 127 IGAVSKLLDLELSKEEIAKMGHKVELLVQGASSGIDPTVSAIGGFLYYKQGEFEHLPFVE 186
IGA+ + + E A H+VE+ VQGA+S +D +S GG +Y +
Sbjct: 106 IGALDRYHGRDHGPGETAARAHRVEVDVQGAASPLDTAISTYGGLVYLDSQRRVRQFEAD 165
Query: 187 L-PIVVGYTGSSGSTKELVAMVRRRYEEMPELIEPILESMGKLVDKAKEVIISKLDEEEK 245
L +V+ + SG T +VA V R+ P+++ I++++ + + A ++ E
Sbjct: 166 LGDLVIAHLDYSGETARMVAGVAERFRRFPDIMGRIMDTVESITNTAYRELLRNNTEP-- 223
Query: 246 FLKLGELMNINHGLLDALGVSTKKLSELVYAARTAGAIGAKLTGAGGGGCMYALAPGKQR 305
LGELMN+N GLLD++GVST++LS +VY AR AGA G+K+TGAGGGG + A PG
Sbjct: 224 ---LGELMNLNQGLLDSMGVSTRELSMMVYEARNAGAAGSKITGAGGGGSIIAHCPGCVD 280
Query: 306 EVATAI 311
+V TA+
Sbjct: 281 DVVTAL 286
>pir||B69160 mevalonate kinase - Methanobacterium thermoautotrophicum (strain
Delta H) >gi|2621081|gb|AAB84553.1| (AE000796)
mevalonate kinase [Methanobacterium thermoautotrophicum]
Length = 303
Score = 187 bits (471), Expect = 1e-46
Identities = 115/306 (37%), Positives = 172/306 (55%), Gaps = 25/306 (8%)
Query: 7 ASAPAKIILFGEHSVVYGKPAIASAIDLRTYVRAEFNDSGNIKIEAHDIKTPGLIVSFSE 66
ASAPAK ILFGEH+VVY KPAIA+AID R V + S ++ I P L + S
Sbjct: 5 ASAPAKAILFGEHAVVYSKPAIAAAIDRRVTVTVSESSSTHVTI-------PSLGIRHSS 57
Query: 67 DKIYFETDYGKAAEVLSYVRHAIELVLEEADKRTGVSVSITSQIPVGAGLGSSAAVAVAT 126
++ + +L Y+ +EL + + + + + +IP G+GLGSSAA+ VA
Sbjct: 58 ER--------PSGGILDYIGRCLELYHDASP----LDIRVEMEIPAGSGLGSSAALTVAL 105
Query: 127 IGAVSKLLDLELSKEEIAKMGHKVELLVQGASSGIDPTVSAIGGFLYYKQGEFEHLPFVE 186
IG + + + E A H+VE+ VQGA+S +D +S GG +Y +
Sbjct: 106 IGPLDRYHGRDHGPGETAARAHRVEVDVQGAASPLDTAISTYGGLVYLDSQRRVRQFEAD 165
Query: 187 L-PIVVGYTGSSGSTKELVAMVRRRYEEMPELIEPILESMGKLVDKAKEVIISKLDEEEK 245
L +V+ + SG T +VA V R+ P+++ I++++ + + A ++ E
Sbjct: 166 LGDLVIAHLDYSGETARMVAGVAERFRRFPDIMGRIMDTVESITNTAYRELLRNNTEP-- 223
Query: 246 FLKLGELMNINHGLLDALGVSTKKLSELVYAARTAGAIGAKLTGAGGGGCMYALAPGKQR 305
LGELMN+N GLLD++GVST++LS +VY AR AGA G+K+TGAGGGG + A PG
Sbjct: 224 ---LGELMNLNQGLLDSMGVSTRELSMMVYEARNAGAAGSKITGAGGGGSIIAHCPGCVD 280
Query: 306 EVATAI 311
+V TA+
Sbjct: 281 DVVTAL 286
>gb|AAK40711.1| Mevalonate kinase [Sulfolobus solfataricus]
Length = 314
Score = 171 bits (430), Expect = 7e-42
Identities = 115/327 (35%), Positives = 180/327 (54%), Gaps = 21/327 (6%)
Query: 4 LVLASAPAKIILFGEHSVVYGKPAIASAIDLRTYVRAEFNDSGNIKIEAHDIKTPGLIVS 63
+V A P K+ LFGEH+VVY +PAIA I V+ ND I + +IK G+ +
Sbjct: 2 MVEAKVPLKLTLFGEHAVVYDRPAIAMTISESLKVKVSENDKFLIISPSLNIK--GVKLD 59
Query: 64 FSEDKIYFETDYGKAAEVLSYVRHAIELVLEEADKRTGVSVSITSQIPVGAGLGSSAAVA 123
+E KI E+D +A +VL YV VL + + V + I S + GLG+SAAV
Sbjct: 60 LNEMKI--ESD--EAKKVLRYVFE----VLNYFEMKKPVKIEINSTVEPSVGLGTSAAVI 111
Query: 124 VATIGAVSKLLDLELSKEEIAKMGHKVELLVQGASSGIDPTVSAIGGFLYYKQG--EFEH 181
V T+ A SK L ++LS++EIAK+ H +EL VQG +S +D GG +Y+ G FE
Sbjct: 112 VGTVAAYSKYLGIDLSRDEIAKISHNIELKVQGIASRMDTYTETYGGLIYFPAGGKGFEK 171
Query: 182 LPFVELPIVVGYTGSSGSTKELVAMVRRRYEEMPELIEPILESMGKLVDKAKEVIISKLD 241
+ + GY S ST +++ VR E E+ E IL+ +G++ ++AK +I+
Sbjct: 172 ID-TNFELTAGYIRRSMSTADVLWRVRTLKESNKEVFENILDVIGEITNRAKSLIV---- 226
Query: 242 EEEKFLKLGELMNINHGLLDALGVSTKKLSELVYAARTAGAIGAKLTGAGGGGCMYALAP 301
E+ F +LG LM +NHGLL +LG+++ + E+V A+ G G K++G G GG + +
Sbjct: 227 -EQNFEELGLLMYVNHGLLFSLGITSPEADEIVSRAKQLGIKGCKISGGGAGGSIICI-- 283
Query: 302 GKQREVATAIKIAGGTPMITRISKEGL 328
K E ++ + + ++K+G+
Sbjct: 284 -KSVEAEVLLRSYNARIVNSTLTKDGV 309
>gi|11499870 mevalonate kinase (mvk) [Archaeoglobus fulgidus]
>gi|8928130|sp|O27995|KIME_ARCFU MEVALONATE KINASE (MK)
>gi|7483872|pir||A69536 mevalonate kinase (mvk) homolog
- Archaeoglobus fulgidus >gi|2648230|gb|AAB88965.1|
(AE000946) mevalonate kinase (mvk) [Archaeoglobus
fulgidus]
Length = 284
Score = 168 bits (420), Expect = 1e-40
Identities = 117/332 (35%), Positives = 173/332 (51%), Gaps = 52/332 (15%)
Query: 5 VLASAPAKIILFGEHSVVYGKPAIASAIDLRTYVRAEFNDSGNIKIEAHDIKTPGLIVSF 64
++ASAP KIILFGEH+VVYG+ A+ SAI+LR V
Sbjct: 1 MIASAPGKIILFGEHAVVYGRHAVVSAINLRCRVSVR----------------------- 37
Query: 65 SEDKIYFETDYGKAAEVLSYVRH--AIELVLEEADKRT--GVSVSITSQIPVGAGLGSSA 120
D+ + G++ L Y RH ++ V + R G + I S+IP+G+GLGSSA
Sbjct: 38 KSDRFLIRSSLGESG--LDYQRHPYVVQAVKRFGELRNIPGAEIEIESEIPIGSGLGSSA 95
Query: 121 AVAVATIGAVSKLLDLELSKEEIAKMGHKVELLVQGASSGIDPTVSAIGGFLYYKQGEFE 180
AV VATI A++ D ++ KE I +M +VE+ VQG +SGIDP +S GG + +
Sbjct: 96 AVIVATIAALNAEFDGDMDKEAIFQMAKQVEIDVQGRASGIDPFISTFGGSWLFPERRKV 155
Query: 181 HLPFVELPIVVGYTGSSGSTKELVAMVRRRYEEMPELIEPILESMGKLVDKAKEVIISKL 240
+PF I G S ST E+VA V E PE+++ I +++ + +A +V ++
Sbjct: 156 EMPFKFFVINFG----SRSTAEMVAKVAELRERHPEVVDKIFDAIDAISLEASDVGSAE- 210
Query: 241 DEEEKFLKLGELMNINHGLLDALGVSTKKLSELVYAARTAGAIGAKLTGAGGGGCMYALA 300
+L EL+ IN LL A+GVS ++ + G + AK+TGAGGGGC++ L
Sbjct: 211 -------RLEELIAINQSLLRAIGVSNPEIDRTIAELERMG-LNAKITGAGGGGCIFGLF 262
Query: 301 PGKQREVATAIKIAGGTPMITRISKEGLRIEE 332
G++ + + I KEG+RIEE
Sbjct: 263 KGEKPKGS----------FIVEPEKEGVRIEE 284
>sp|Q58487|KIME_METJA MEVALONATE KINASE (MK) >gi|2129120|pir||F64435 mevalonate kinase
(EC 2.7.1.36) - Methanococcus jannaschii
>gi|1591731|gb|AAB99088.1| (U67551) mevalonate kinase
[Methanococcus jannaschii]
Length = 312
Score = 146 bits (365), Expect = 3e-34
Identities = 103/334 (30%), Positives = 172/334 (50%), Gaps = 29/334 (8%)
Query: 5 VLASAPAKIILFGEHSVVYGKPAIASAIDLRTYVRAEFNDSGNIKIEAHDIKTPGLIVSF 64
++ P+K+ILFGEH+VVYG AI+ AIDL + + + I + +D+ L ++
Sbjct: 1 MIIETPSKVILFGEHAVVYGYRAISMAIDLTSTIEIKETQEDEIILNLNDLNK-SLGLNL 59
Query: 65 SEDKIYFETDYGKAAEVLSYVRHAIELVLEEADKRTGVSVSITSQIPVGAGLGSSAAVAV 124
+E K ++G L +++ ++ + + +TG ++I+S+IP+ GLGSSA++ +
Sbjct: 60 NEIKNINPNNFGDFKYCLCAIKNTLDYL--NIEPKTGFKINISSKIPISCGLGSSASITI 117
Query: 125 ATIGAVSKLLDLELSKEEIAKMGHKVELLVQGASSGIDPTVSAIGGFLYYKQGEFEHLPF 184
TI AVS + EL +EIAK+G+ VE +QG +S D + G L K +F
Sbjct: 118 GTIKAVSGFYNKELKDDEIAKLGYMVEKEIQGKASITDTSTITYKGILEIKNNKFR---- 173
Query: 185 VELPIVVGYTGSSGSTKELVAMVRRRYEEMPELIEPI--LESMGKLVDKAKEVI--ISKL 240
I + + K L+ +R ++ EL+ + +E+ ++ + +VI K+
Sbjct: 174 ---KIKGEFEEFLKNCKFLIVYAEKRKKKTAELVNEVAKIENKDEIFKEIDKVIDEALKI 230
Query: 241 DEEEKFLKLGELMNINHGLLDALGVSTKKLSELVYAARTAGAIGAKLTGAGGGGCMYALA 300
+E F G+LM NH LL L +ST KL +V G GAKLTGAGGGGC+ L
Sbjct: 231 KNKEDF---GKLMTKNHELLKKLNISTPKLDRIVDIGNRFG-FGAKLTGAGGGGCVIILV 286
Query: 301 PGKQREVATAIKIAGGTPMITRISKEGLRIEEVR 334
++ + ++ ++KE +RI R
Sbjct: 287 NEEKEK-----------ELLKELNKEDVRIFNCR 309
>gi|4557769 mevalonate kinase [Homo sapiens] >gi|417215|sp|Q03426|KIME_HUMAN
MEVALONATE KINASE (MK) >gi|284302|pir||A42919 mevalonate
kinase (EC 2.7.1.36) - human >gi|187561|gb|AAB59362.1|
(M88468) mevalonate kinase [Homo sapiens]
>gi|450347|emb|CAA53060.1| (X75311) ORF for mevalonate
kinase [Homo sapiens] >gi|9049533|gb|AAF82407.1|
(AF217535) mevalonate kinase [Homo sapiens]
Length = 396
Score = 133 bits (331), Expect = 3e-30
Identities = 110/368 (29%), Positives = 177/368 (47%), Gaps = 64/368 (17%)
Query: 1 MPRLVLASAPAKIILFGEHSVVYGKPAIASAIDLRTYVRAEFNDSGNIKIEAHDIKTPGL 60
+ ++L SAP K+IL GEH+VV+GK A+A +++LRT++R + + +G + D+ P +
Sbjct: 2 LSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKV-----DLSLPNI 56
Query: 61 IVSFSEDKIYFE---TDYGKAAEVLSYVRHAIELVLEEADKRTGVSVS------------ 105
+ + D + T + + +V + +E + E A +V+
Sbjct: 57 GIKRAWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLY 116
Query: 106 ----------------ITSQIPVGAGLGSSAAVAVATIGAVSKLL--------------- 134
+ S++P GAGLGSSAA +V A+ +
Sbjct: 117 LSICRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNR 176
Query: 135 ----DLELSKEEIAKMGHKVELLVQGASSGIDPTVSAIGGFLYYKQGEFEHLP-FVELPI 189
DLEL I K + E ++ G SG+D VS GG L Y QG+ L L I
Sbjct: 177 WTKEDLEL----INKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQI 232
Query: 190 VVGYTGSSGSTKELVAMVRRRYEEMPELIEPILESMGKLVDKAKEVI--ISKLDEEEKFL 247
++ T +T+ LVA VR R + PE++ P+L S+ + + + V+ + + E++L
Sbjct: 233 LLTNTKVPRNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYL 292
Query: 248 KLGELMNINHGLLDALGVSTKKLSELVYAARTAGAIGAKLTGAGGGGC-MYALAPGKQRE 306
L EL+++N L+ALGV L +L R G + +KLTGAGGGGC + L PG ++
Sbjct: 293 VLEELIDMNQHHLNALGVGHASLDQLCQVTRARG-LHSKLTGAGGGGCGITLLKPGLEQP 351
Query: 307 VATAIKIA 314
A K A
Sbjct: 352 EVEATKQA 359
>emb|CAA53059.1| (X75311) ORF for viral-cellular fusion transcript [Homo sapiens]
Length = 557
Score = 133 bits (331), Expect = 3e-30
Identities = 110/368 (29%), Positives = 177/368 (47%), Gaps = 64/368 (17%)
Query: 1 MPRLVLASAPAKIILFGEHSVVYGKPAIASAIDLRTYVRAEFNDSGNIKIEAHDIKTPGL 60
+ ++L SAP K+IL GEH+VV+GK A+A +++LRT++R + + +G + D+ P +
Sbjct: 163 LSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKV-----DLSLPNI 217
Query: 61 IVSFSEDKIYFE---TDYGKAAEVLSYVRHAIELVLEEADKRTGVSVS------------ 105
+ + D + T + + +V + +E + E A +V+
Sbjct: 218 GIKRAWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLY 277
Query: 106 ----------------ITSQIPVGAGLGSSAAVAVATIGAVSKLL--------------- 134
+ S++P GAGLGSSAA +V A+ +
Sbjct: 278 LSICRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNR 337
Query: 135 ----DLELSKEEIAKMGHKVELLVQGASSGIDPTVSAIGGFLYYKQGEFEHLP-FVELPI 189
DLEL I K + E ++ G SG+D VS GG L Y QG+ L L I
Sbjct: 338 WTKEDLEL----INKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQI 393
Query: 190 VVGYTGSSGSTKELVAMVRRRYEEMPELIEPILESMGKLVDKAKEVI--ISKLDEEEKFL 247
++ T +T+ LVA VR R + PE++ P+L S+ + + + V+ + + E++L
Sbjct: 394 LLTNTKVPRNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYL 453
Query: 248 KLGELMNINHGLLDALGVSTKKLSELVYAARTAGAIGAKLTGAGGGGC-MYALAPGKQRE 306
L EL+++N L+ALGV L +L R G + +KLTGAGGGGC + L PG ++
Sbjct: 454 VLEELIDMNQHHLNALGVGHASLDQLCQVTRARG-LHSKLTGAGGGGCGITLLKPGLEQP 512
Query: 307 VATAIKIA 314
A K A
Sbjct: 513 EVEATKQA 520
>gi|11436567 mevalonate kinase [Homo sapiens]
Length = 421
Score = 133 bits (331), Expect = 3e-30
Identities = 110/368 (29%), Positives = 177/368 (47%), Gaps = 64/368 (17%)
Query: 1 MPRLVLASAPAKIILFGEHSVVYGKPAIASAIDLRTYVRAEFNDSGNIKIEAHDIKTPGL 60
+ ++L SAP K+IL GEH+VV+GK A+A +++LRT++R + + +G + D+ P +
Sbjct: 27 LSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKV-----DLSLPNI 81
Query: 61 IVSFSEDKIYFE---TDYGKAAEVLSYVRHAIELVLEEADKRTGVSVS------------ 105
+ + D + T + + +V + +E + E A +V+
Sbjct: 82 GIKRAWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLY 141
Query: 106 ----------------ITSQIPVGAGLGSSAAVAVATIGAVSKLL--------------- 134
+ S++P GAGLGSSAA +V A+ +
Sbjct: 142 LSICRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNR 201
Query: 135 ----DLELSKEEIAKMGHKVELLVQGASSGIDPTVSAIGGFLYYKQGEFEHLP-FVELPI 189
DLEL I K + E ++ G SG+D VS GG L Y QG+ L L I
Sbjct: 202 WTKEDLEL----INKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQI 257
Query: 190 VVGYTGSSGSTKELVAMVRRRYEEMPELIEPILESMGKLVDKAKEVI--ISKLDEEEKFL 247
++ T +T+ LVA VR R + PE++ P+L S+ + + + V+ + + E++L
Sbjct: 258 LLTNTKVPRNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYL 317
Query: 248 KLGELMNINHGLLDALGVSTKKLSELVYAARTAGAIGAKLTGAGGGGC-MYALAPGKQRE 306
L EL+++N L+ALGV L +L R G + +KLTGAGGGGC + L PG ++
Sbjct: 318 VLEELIDMNQHHLNALGVGHASLDQLCQVTRARG-LHSKLTGAGGGGCGITLLKPGLEQP 376
Query: 307 VATAIKIA 314
A K A
Sbjct: 377 EVEATKQA 384
>gb|AAG02445.1|AF290095_1 (AF290095) mevalonate kinase [Enterococcus faecium]
Length = 314
Score = 132 bits (329), Expect = 5e-30
Identities = 100/308 (32%), Positives = 154/308 (49%), Gaps = 24/308 (7%)
Query: 12 KIILFGEHSVVYGKPAIASAIDLRTYVRAEFNDSGNIKIEAHDIKTPGLIVSFSEDKIYF 71
KIIL GEH+VVYG+PAIA T V A +E D L+ S Y+
Sbjct: 12 KIILMGEHAVVYGEPAIAFPF-YATKVTAF--------LEELDAMDDQLVSS------YY 56
Query: 72 ETDYGKAAEVLSYVRHAIELVLEEADKRTGVSVSITSQIPVGAGLGSSAAVAVATIGAVS 131
+ +A L ++ + ++ D + + ++I S IP G+GSSAAVA A A
Sbjct: 57 SGNLAEAPHALKNIKKLFIHLKKQHDIQKNLQLTIESTIPAERGMGSSAAVATAVTRAFY 116
Query: 132 KLLDLELSKEEIAKMGHKVELLVQGASSGIDPTVSAIGGFLYYKQGE-FEHLPF-VELPI 189
L LS+E + + E + G SGID ++ +Y+ +G F++ ++ +
Sbjct: 117 DYLAFPLSREILLENVQLSEKIAHGNPSGIDAAATSSLQPIYFTKGHPFDYFSLNIDAFL 176
Query: 190 VVGYTGSSGSTKELVAMVRRRYEEMPELIEPILESMGKLVDKAKEVIISKLDEEEKFLKL 249
+V TG G T+E V V +E P +++ +G L +AK+ II E L
Sbjct: 177 IVADTGIKGQTREAVKDVAHLFETQPHETGQMIQKLGYLTKQAKQAIIENSPET-----L 231
Query: 250 GELMNINHGLLDALGVSTKKLSELVYAARTAGAIGAKLTGAGGGGCMYALAPGKQR--EV 307
+ M+ + LL+ L +S L+ L+ A+ GA+GAKLTG G GGCM ALA K + E+
Sbjct: 232 AQTMDESQSLLEKLTISNDFLNLLIQTAKDTGALGAKLTGGGRGGCMIALAQTKTKAQEI 291
Query: 308 ATAIKIAG 315
+ A++ AG
Sbjct: 292 SQALEDAG 299
>sp|P17256|KIME_RAT MEVALONATE KINASE (MK) >gi|111959|pir||A35629 mevalonate kinase (EC
2.7.1.36) [validated] - rat >gi|205378|gb|AAA41588.1|
(M29472) mevalonate kinase (EC 2.7.1.36) [Rattus
norvegicus]
Length = 395
Score = 131 bits (326), Expect = 1e-29
Identities = 113/359 (31%), Positives = 173/359 (47%), Gaps = 46/359 (12%)
Query: 1 MPRLVLASAPAKIILFGEHSVVYGKPAIASAIDLRTYVRAEFNDSGNIKI---------- 50
+ ++L SAP K+IL GEH+VV+GK A+A A++LRT++ +G + +
Sbjct: 2 LSEVLLVSAPGKVILHGEHAVVHGKVALAVALNLRTFLVLRPQSNGKVSLNLPNVGIKQV 61
Query: 51 --------------EAHDIKTPGLIVSFSEDKIYFETDYGKAAEVLSYVRHAIELVLEEA 96
E D+ P L K+ E LS + +
Sbjct: 62 WDVATLQLLDTGFLEQGDVPAPTLEQLEKLKKVAGLPRDCVGNEGLSLLAFLYLYLAICR 121
Query: 97 DKRT--GVSVSITSQIPVGAGLGSSAAVAVATIGAV--------SKLLDL-------ELS 139
+RT + + + S++P GAGLGSSAA +V A+ + L D E
Sbjct: 122 KQRTLPSLDIMVWSELPPGAGLGSSAAYSVCVAAALLTACEEVTNPLKDRGSIGSWPEED 181
Query: 140 KEEIAKMGHKVELLVQGASSGIDPTVSAIGGFLYYKQGEFEHLPFVE-LPIVVGYTGSSG 198
+ I K ++ E ++ G SG+D +VS GG L Y+QG+ L + L I++ T
Sbjct: 182 LKSINKWAYEGERVIHGNPSGVDNSVSTWGGALRYQQGKMSSLKRLPALQILLTNTKVPR 241
Query: 199 STKELVAMVRRRYEEMPELIEPILESMGKLVDKAKEVI--ISKLDEEEKFLKLGELMNIN 256
STK LVA VR R + PE++ P+L S+ + + + V+ ++ E++L L ELM++N
Sbjct: 242 STKALVAGVRSRLIKFPEIMAPLLTSIDAISLECERVLGEMAAAPVPEQYLVLEELMDMN 301
Query: 257 HGLLDALGVSTKKLSELVYAARTAGAIGAKLTGAGGGGC-MYALAPGKQREVATAIKIA 314
L+ALGV L +L G + +KLTGAGGGGC + L PG +R A K A
Sbjct: 302 QHHLNALGVGHASLDQLCQVTAAHG-LHSKLTGAGGGGCGITLLKPGLERAKVEAAKQA 359
>sp|Q9Y946|KIME_AERPE MEVALONATE KINASE (MK) >gi|7521212|pir||F72474 probable mevalonate
kinase APE2439 - Aeropyrum pernix (strain K1)
>gi|5106143|dbj|BAA81454.1| (AP000064) 324aa long
hypothetical mevalonate kinase [Aeropyrum pernix]
Length = 324
Score = 131 bits (325), Expect = 2e-29
Identities = 110/343 (32%), Positives = 163/343 (47%), Gaps = 31/343 (9%)
Query: 1 MPRLVLASAPAKIILFGEHSVVYGKPAIASAIDLRTYVRAEFNDSGNI----KIEAHDIK 56
M R ASAP K+I+ GEH VV G AI +AI R V G + + H
Sbjct: 1 MRRAARASAPGKVIIVGEHFVVRGSLAIVAAIGRRLRVTVRSGGKGIVLESSMLGRHSAP 60
Query: 57 TPGLIVSFSEDKIYFETDYGKAAEVLSYVRHAIELVLEEADKRTGV---SVSITSQIPVG 113
PG G AA+V + I ++ A + V ++ + S IP
Sbjct: 61 LPG---------------QGAAAKVSPVLEPYIAVLRSLAARGYSVVPHTILVESGIPPR 105
Query: 114 AGLGSSAAVAVATIGAVSKLLDLELSKEEIAKMGHKVELLVQGASSGIDPTVSAIGGFLY 173
AGLGSSAA VA + S + LS E++ + + E + G SG+D T++ GG L
Sbjct: 106 AGLGSSAASMVAYALSYSAMHGDPLSAEDLYSVAMEGEKIAHGKPSGVDVTIAVRGGVLA 165
Query: 174 YKQGE--FEHLP-FVELPIVVGYTGSSGSTKELVAMVRRRYEEMPELIEPILESMGKLVD 230
Y++GE + P + ++V TG T+++V V + + E I + +
Sbjct: 166 YRRGENPVDIRPGLTGVTLLVADTGVERRTRDVVEHVLSIADALGEASTYIYRAADLIAR 225
Query: 231 KAKEVIISKLDEEEKFLKLGELMNINHGLLDALGVSTKKLSELVYAARTAGAIGAKLTGA 290
+A I K D E +LG +MN GLL +LG S+ ++ LVY R+AGA+GAKLTGA
Sbjct: 226 EALHAI-EKGDAE----RLGLIMNAAQGLLSSLGASSLEIETLVYRMRSAGALGAKLTGA 280
Query: 291 GGGGCMYAL-APGKQREVATAIKIAGGTPMITRISKEGLRIEE 332
G GGC+ L G+ ++ + I++EG R+EE
Sbjct: 281 GWGGCVIGLFKEGEVERGLESVVESSSQAFTASIAEEGARLEE 323
>sp|Q9R008|KIME_MOUSE MEVALONATE KINASE (MK) >gi|6006984|gb|AAF00700.1|AF137598_1
(AF137598) mevalonate kinase [Mus musculus]
Length = 395
Score = 127 bits (315), Expect = 2e-28
Identities = 107/355 (30%), Positives = 166/355 (46%), Gaps = 46/355 (12%)
Query: 5 VLASAPAKIILFGEHSVVYGKPAIASAIDLRTYVRAEFNDSGNIKIEAHDI--------- 55
+L SAP K+IL GEH+VV+GK A+A+A++LRT++ +G + + +I
Sbjct: 6 LLVSAPGKVILHGEHAVVHGKVALAAALNLRTFLLLRPQSNGKVSVNLPNIGIKQVWDVG 65
Query: 56 KTPGLIVSFSE------------DKIYFETDY-----GKAAEVLSYVRHAIELVLEEADK 98
L SF E +K+ D G L + + +
Sbjct: 66 MLQRLDTSFLEQGDVSVPTLEQLEKLKKMGDLPRDRAGNEGMALLAFLYLYLAICRKQRT 125
Query: 99 RTGVSVSITSQIPVGAGLGSSAAVAVATIGAVSKLLDL---------------ELSKEEI 143
+ + + S++P GAGLGSSAA +V A+ + E + I
Sbjct: 126 LPSLDMVVWSELPPGAGLGSSAAYSVCLAAALLTACEEVSNPLKDGVSVSRWPEEDLKSI 185
Query: 144 AKMGHKVELLVQGASSGIDPTVSAIGGFLYYKQGEFEHLPFV-ELPIVVGYTGSSGSTKE 202
K + E ++ G SG+D VS GG L ++QG L + L I++ T STK
Sbjct: 186 NKWAFEGERVIHGNPSGVDNAVSTWGGALRFQQGTMSSLKSLPSLQILLTNTKVPRSTKA 245
Query: 203 LVAMVRRRYEEMPELIEPILESMGKLVDKAKEVI--ISKLDEEEKFLKLGELMNINHGLL 260
LVA VR R + PE++ P+L S+ + + + V+ + E++L L EL+++N L
Sbjct: 246 LVAAVRSRLTKFPEIVAPLLTSIDAISLECERVLGEMVAAPVPEQYLVLEELIDMNQHHL 305
Query: 261 DALGVSTKKLSELVYAARTAGAIGAKLTGAGGGGC-MYALAPGKQREVATAIKIA 314
+ALGV L +L G + +KLTGAGGGGC + L PG ++ A K A
Sbjct: 306 NALGVGHNSLDQLCQVTAAHG-LHSKLTGAGGGGCGITLLKPGLEQATVEAAKQA 359
>gb|AAG02424.1|AF290087_1 (AF290087) mevalonate kinase [Staphylococcus aureus]
Length = 306
Score = 126 bits (313), Expect = 4e-28
Identities = 107/319 (33%), Positives = 160/319 (49%), Gaps = 28/319 (8%)
Query: 1 MPRLVLASAPAKIILFGEHSVVYGKPAIASAIDLRTYVRAEFNDSGNIKIEAHDIKTPGL 60
M R + KIIL GEH+V +G+PAIA FN +G IK+ +++ G
Sbjct: 1 MTRKGYGESTGKIILIGEHAVTFGEPAIA----------VPFN-AGKIKVLIEALES-GN 48
Query: 61 IVSFSEDKIYFETDYGKAAEVLSYVRHAIELVLEEADKRTGVSVSITSQIPVGAGLGSSA 120
S D +Y Y + S V +EL + ++V+I + +P GLGSSA
Sbjct: 49 YSSIKSD-VYDGMLYDAPDHLKSLVNRFVEL----NNITEPLAVTIQTNLPPSRGLGSSA 103
Query: 121 AVAVATIGAVSKLLDLELSKEEIAKMGHKVELLVQGASSGIDPTVSAIGGFLYYKQGEFE 180
AVAVA + A L L+KEE+ + + E + G SGID G +++++G+ E
Sbjct: 104 AVAVAFVRASYDFLGKSLTKEELIEKANWAEQIAHGKPSGIDTQTIVSGKPVWFQKGQAE 163
Query: 181 HLPFVELP--IVVGYTGSSGSTKELVAMVRRRYEEMPELIEPILESMGKLVDKAKEVIIS 238
L + L +VV TG GST++ V V + E+ P+ + + + +GKLV +A +VI
Sbjct: 164 TLKTLSLDGYMVVIDTGVKGSTRQAVEDVHKLCED-PQYMSHV-KHIGKLVLRASDVI-- 219
Query: 239 KLDEEEKFLKLGELMNINHGLLDALGVSTKKLSELVYAARTAGAIGAKLTGAGGGGCMYA 298
E F L ++ N H L AL VS K+ +L+ + GAI KLTGAG GG M
Sbjct: 220 ---EHHNFEALADIFNECHADLKALTVSHDKIEQLMKIGKENGAIAGKLTGAGRGGSMLL 276
Query: 299 LAPG--KQREVATAIKIAG 315
LA + + A++ AG
Sbjct: 277 LAKDLPTAKNIVKAVEKAG 295
>gb|AAG02440.1|AF290093_1 (AF290093) mevalonate kinase [Enterococcus faecalis]
Length = 314
Score = 126 bits (313), Expect = 4e-28
Identities = 94/302 (31%), Positives = 147/302 (48%), Gaps = 24/302 (7%)
Query: 6 LASAPAKIILFGEHSVVYGKPAIASAIDLRTYVRAEFNDSGNIKIEAHDIKTPGLIVSFS 65
L A KIIL GEH+VVYG+PAIA T + A F + ++I+ GL+
Sbjct: 8 LGQATGKIILMGEHAVVYGEPAIAFPFQA-TEITAVFTPAKTMQIDCAYFT--GLLEDVP 64
Query: 66 EDKIYFETDYGKAAEVLSYVRHAIELVLEEADKRTGVSVSITSQIPVGAGLGSSAAVAVA 125
++ A + V+ + + E+ K T +++TS IP G+GSSAA AVA
Sbjct: 65 QE----------LANIKEVVQQTLHFLKEDTFKGT---LTLTSTIPAERGMGSSAATAVA 111
Query: 126 TIGAVSKLLDLELSKEEIAKMGHKVELLVQGASSGIDPTVSAIGGFLYYKQG---EFEHL 182
+ ++ D + +E+ ++ E + G SGID ++ L++ +G +
Sbjct: 112 IVRSLFDYFDYAYTYQELFELVSLSEKIAHGNPSGIDAAATSGADPLFFTRGFPPTHFSM 171
Query: 183 PFVELPIVVGYTGSSGSTKELVAMVRRRYEEMPELIEPILESMGKLVDKAKEVIISKLDE 242
+VV TG G T+E V + + + P I ++ +G +AK+ I+ D+
Sbjct: 172 NLSNAYLVVADTGIKGQTREAVKDIAQLAQNNPTAIAETMKQLGSFTKEAKQAILQ--DD 229
Query: 243 EEKFLKLGELMNINHGLLDALGVSTKKLSELVYAARTAGAIGAKLTGAGGGGCMYALAPG 302
++K LG+LM + L L VS L LV + GA+GAKLTG G GGCM AL
Sbjct: 230 KQK---LGQLMTLAQEQLQQLTVSNDMLDRLVALSLEHGALGAKLTGGGRGGCMIALTDN 286
Query: 303 KQ 304
K+
Sbjct: 287 KK 288
>sp|Q09780|KIME_SCHPO PUTATIVE MEVALONATE KINASE (MK) >gi|2117774|pir||S62440 mevalonate
kinase (EC 2.7.1.36) - fission yeast
(Schizosaccharomyces pombe) >gi|1008996|emb|CAA91104.1|
(Z54308) putative mevalonate kinase [Schizosaccharomyces
pombe] >gi|2967444|dbj|BAA25169.1| (AB000541) putative
mevalonate kinase [Schizosaccharomyces pombe]
Length = 404
Score = 126 bits (313), Expect = 4e-28
Identities = 98/346 (28%), Positives = 162/346 (46%), Gaps = 42/346 (12%)
Query: 1 MPRLVLASAPAKIILFGEHSVVYGKPAIASAIDLRTYVRAEFNDSGNIKIEAHDIKTPGL 60
M + ++ S+P K ILFGEH+VVYG A+A+A+ LR+Y + + ++ I I DI T
Sbjct: 1 MSKSLIVSSPGKTILFGEHAVVYGATALAAAVSLRSYCKLQTTNNNEIVIVMSDIGTERR 60
Query: 61 --IVSFSEDKIYFET-DYGKAAEVLSYVRHAIELVLEE-------------------ADK 98
+ S + E + ++ L ++ EL+ E +
Sbjct: 61 WNLQSLPWQHVTVENVQHPASSPNLDLLQGLGELLKNEENGLIHSAMLCTLYLFTSLSSP 120
Query: 99 RTGVSVSITSQIPVGAGLGSSAAVAVATIGAV-----------SKLLDLELSKEEIAKMG 147
G +++I+SQ+P+GAGLGSSA ++V ++ S L + I
Sbjct: 121 SQGCTLTISSQVPLGAGLGSSATISVVVATSLLLAFGNIEPPSSNSLQNNKALALIEAWS 180
Query: 148 HKVELLVQGASSGIDPTVSAIGGFLYYKQGEFEHLPFVE-------LPIVVGYTGSSGST 200
E + G SGID V+ GG + +++ E L +++ T ST
Sbjct: 181 FLGECCIHGTPSGIDNAVATNGGLIAFRKATAHQSAMKEFLKPKDTLSVMITDTKQPKST 240
Query: 201 KELVAMVRRRYEEMPELIEPILESMGKLVDKAKEVIISKLDEEEKFLKLGELMNINHGLL 260
K+LV V E +P +I+ I++++ + A + S+ D+ KLGE + +N LL
Sbjct: 241 KKLVQGVFELKERLPTVIDSIIDAIDGISKSAVLALTSESDKNSSAKKLGEFIVLNQKLL 300
Query: 261 DALGVSTKKLSELVYAARTAGAIGAKLTGAGGGGCMYALAPGKQRE 306
+ LGVS + ++ A ++ G KLTGAGGGGC L + +E
Sbjct: 301 ECLGVSHYSIDRVLQATKSIG--WTKLTGAGGGGCTITLLTPECKE 344
>gi|6323864 mevalonate kinase; Erg12p [Saccharomyces cerevisiae]
>gi|125407|sp|P07277|KIME_YEAST MEVALONATE KINASE (MK)
(MVK) >gi|73086|pir||BVBYR1 mevalonate kinase (EC
2.7.1.36) - yeast (Saccharomyces cerevisiae)
>gi|3684|emb|CAA39359.1| (X55875) mevalonate kinase
[Saccharomyces cerevisiae] >gi|4287|emb|CAA29487.1|
(X06114) ORF1 (put. RAR1 protein) (AA 1-443)
[Saccharomyces cerevisiae] >gi|854460|emb|CAA89923.1|
(Z49809) Rar1p [Saccharomyces cerevisiae]
Length = 443
Score = 125 bits (311), Expect = 7e-28
Identities = 118/358 (32%), Positives = 177/358 (48%), Gaps = 66/358 (18%)
Query: 6 LASAPAKIILFGEHSVVYGKPAIASAID-LRTYVR-AEFNDSGNIKIEAHDIK------- 56
L SAP K+I+FGEHS VY KPA+A+++ LRTY+ +E + I+++ DI
Sbjct: 6 LTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFNHKWSI 65
Query: 57 ------TPGLIVSFSEDKIYFETDYGKAAEVLSYVRHAIELVLEE--------------- 95
T + S K TD G + E++S + + + E
Sbjct: 66 NDFNAITEDQVNSQKLAKAQQATD-GLSQELVSLLDPLLAQLSESFHYHAAFCFLYMFVC 124
Query: 96 -ADKRTGVSVSITSQIPVGAGLGSSA------AVAVATIGAVSKLLDLELSKEE----IA 144
+ S+ S +P+GAGLGSSA A+A+A +G + DLE E +
Sbjct: 125 LCPHAKNIKFSLKSTLPIGAGLGSSASISVSLALAMAYLGGLIGSNDLEKLSENDKHIVN 184
Query: 145 KMGHKVELLVQGASSGIDPTVSAIGGFLYYKQ---------GEFEHL-PFVELPIVVGYT 194
+ E + G SGID V+ G L +++ F+ L F +P+++ YT
Sbjct: 185 QWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKFLDDFPAIPMILTYT 244
Query: 195 GSSGSTKELVAMVRRRY-EEMPELIEPILESMGKLVDKAKEVI--ISK---LDEE----- 243
STK+LVA VR E+ PE+++PIL++MG+ + E++ +SK D+E
Sbjct: 245 RIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTKLSKCKGTDDEAVETN 304
Query: 244 -EKFLKLGELMNINHGLLDALGVSTKKLSELVYAARTAGAIGA-KLTGAGGGGCMYAL 299
E + +L EL+ INHGLL ++GVS L EL+ IG+ KLTGAGGGGC L
Sbjct: 305 NELYEQLLELIRINHGLLVSIGVSHPGL-ELIKNLSDDLRIGSTKLTGAGGGGCSLTL 361
>gb|AAD45421.1|L77688_1 (L77688) mevalonate kinase [Arabidopsis thaliana]
Length = 376
Score = 125 bits (310), Expect = 9e-28
Identities = 110/343 (32%), Positives = 161/343 (46%), Gaps = 48/343 (13%)
Query: 5 VLASAPAKIILFGEHSVVYGKPAIASAIDLRTYVRAEFNDSGNIKIEAHDIKTPGLIVSF 64
V A AP KIIL GEH+VV+G A+A+AIDL TYV F N +K L S+
Sbjct: 3 VKARAPGKIILAGEHAVVHGSTAVAAAIDLYTYVTLRFPLPSNNDRLTLQLKDISLEFSW 62
Query: 65 SEDKIYFETDYGKAA-----------EVLSYVRHAIE---LVLEEADKRTGVS------- 103
S +I Y + E L + +E L E+ +G+S
Sbjct: 63 SLARIKEAIPYDSSTLCRSTPASCSEETLKSIAVLVEEQNLPKEKMWLSSGISTFLWLYT 122
Query: 104 ---------VSITSQIPVGAGLGSSAAVAVATIGAVS-------------KLLDLELSKE 141
V I S++P G+GLGSSAA+ VA A+ LD E + E
Sbjct: 123 RIIGFNPATVVINSELPYGSGLGSSAALCVALTAALLASSISEKTRGNGWSSLD-ETNLE 181
Query: 142 EIAKMGHKVELLVQGASSGIDPTVSAIGGFLYYKQGEFEHLPF-VELPIVVGYTGSSGST 200
+ K + E ++ G SGID TVSA G + + GE L + L +++ T +T
Sbjct: 182 LLNKWAFEGEKIIHGKPSGIDNTVSAYGNMIKFCSGEITRLQSNMPLRMLITNTRVGRNT 241
Query: 201 KELVAMVRRRYEEMPELIEPILESMGKLVDKAKEVIISKLDEE--EKFLKLGELMNINHG 258
K LV+ V +R P+ ++ + ++ + + +I SK + EK ++ ELM +N G
Sbjct: 242 KALVSGVSQRAVRHPDAMKSVFNAVDSISKELAAIIQSKDETSVTEKEERIKELMEMNQG 301
Query: 259 LLDALGVSTKKLSELVYAARTAGAIGAKLTGAGGGGCMYALAP 301
LL ++GVS + E V + +KLTGAGGGGC+ L P
Sbjct: 302 LLLSMGVSHSSI-EAVILTTVKHKLVSKLTGAGGGGCVLTLLP 343
>sp|P46086|KIME_ARATH MEVALONATE KINASE (MK) >gi|541880|pir||S42088 mevalonate kinase (EC
2.7.1.36) - Arabidopsis thaliana
>gi|456614|emb|CAA54820.1| (X77793) mevalonate kinase
[Arabidopsis thaliana]
>gi|4883990|gb|AAD31719.1|AF141853_1 (AF141853)
mevalonate kinase [Arabidopsis thaliana]
Length = 378
Score = 123 bits (306), Expect = 3e-27
Identities = 107/345 (31%), Positives = 165/345 (47%), Gaps = 50/345 (14%)
Query: 5 VLASAPAKIILFGEHSVVYGKPAIASAIDLRTYVR-------AEFNDSGNIKIEAHDIKT 57
V A AP KIIL GEH+VV+G A+A+AIDL TYV AE ND ++++ ++
Sbjct: 3 VKARAPGKIILAGEHAVVHGSTAVAAAIDLYTYVTLRFPLPSAENNDRLTLQLKDISLEF 62
Query: 58 PGLI------VSFSEDKIYFETDYGKAAEVLSYVRHAIE---LVLEEADKRTGVS----- 103
+ + + + T + E L + +E L E+ +G+S
Sbjct: 63 SWSLARIKEAIPYDSSTLCRSTPASCSEETLKSIAVLVEEQNLPKEKMWLSSGISTFLWL 122
Query: 104 -----------VSITSQIPVGAGLGSSAAVAVATIGAVS-------------KLLDLELS 139
V I S++P G+GLGSSAA+ VA A+ LD E +
Sbjct: 123 YTRIIGFNPATVVINSELPYGSGLGSSAALCVALTAALLASSISEKTRGNGWSSLD-ETN 181
Query: 140 KEEIAKMGHKVELLVQGASSGIDPTVSAIGGFLYYKQGEFEHLPF-VELPIVVGYTGSSG 198
E + K + E ++ G SGID TVSA G + + GE L + L +++ T
Sbjct: 182 LELLNKWAFEGEKIIHGKPSGIDNTVSAYGNMIKFCSGEITRLQSNMPLRMLITNTRVGR 241
Query: 199 STKELVAMVRRRYEEMPELIEPILESMGKLVDKAKEVIISKLDEE--EKFLKLGELMNIN 256
+TK LV+ V +R P+ ++ + ++ + + +I SK + EK ++ ELM +N
Sbjct: 242 NTKALVSGVSQRAVRHPDAMKSVFNAVDSISKELAAIIQSKDETSVTEKEERIKELMEMN 301
Query: 257 HGLLDALGVSTKKLSELVYAARTAGAIGAKLTGAGGGGCMYALAP 301
GLL ++GVS + E V + +KLTGAGGGGC+ L P
Sbjct: 302 QGLLLSMGVSHSSI-EAVILTTVKHKLVSKLTGAGGGGCVLTLLP 345
>dbj|BAB07817.1| (AB037907) mevalonate kinase [Streptomyces griseolosporeus]
Length = 334
Score = 123 bits (305), Expect = 3e-27
Identities = 103/311 (33%), Positives = 148/311 (47%), Gaps = 20/311 (6%)
Query: 9 APAKIILFGEHSVVYGKPAIASAIDLRTYVRAEFNDSGNIKIEAHDIKTPGLIVSFSEDK 68
A AK IL GEH+VVYG PA+A I + V A SG A P ++ S +
Sbjct: 24 AHAKAILLGEHAVVYGTPALAMPIP-QLAVTASAGWSGR---SAESRGGPTFTMTGSASR 79
Query: 69 IYFETDYGKAAEVLSYVRHAIELVLEEADKRTG--VSVSITSQIPVGAGLGSSAAVAVAT 126
A+ L +R V G + VS+ IP G GLGSSAA A A
Sbjct: 80 AV-------TAQALDGLRRLTASVKAHTGVTDGQHLDVSLDGAIPPGRGLGSSAANARAI 132
Query: 127 IGAVSKLLDLELSKEEIAKMGHKVELLVQGASSGIDPTVSAIGGFLYYKQGEFEHLPF-V 185
I A++ L EL++ E+ + + E L G +SG+D L ++ G + L
Sbjct: 133 ILALADLFGRELTEGEVFDLVQEAENLTHGRASGVDAVTVGATAPLLFRAGTAQALDIGC 192
Query: 186 ELPIVVGYTGSSGSTKELVAMVRRRYEEMPELIEPILESMGKLVDKAKEVIISKLDEEEK 245
+ VV +G++GSTKE + ++R + E + LVD A+ + E E
Sbjct: 193 DALFVVADSGTAGSTKEAIELLRAGFRAGAGKEERFMHRAAHLVDDARASLAE--GEPEA 250
Query: 246 FLKLGELMNINHGLLDALGVSTKKLSELVYAARTAGAIGAKLTGAGGGGCMYALA-PGKQ 304
F G + HGLL G+ST ++ LV AA A ++GAK+TG G GGC+ A++ P +
Sbjct: 251 F---GSCLTEYHGLLRGAGLSTDRIDALVDAALQADSLGAKITGGGLGGCVLAMSRPERA 307
Query: 305 REVATAIKIAG 315
EVA + AG
Sbjct: 308 EEVARQLHAAG 318
>gb|AAF58481.1| (AE003821) CG16804 gene product [Drosophila melanogaster]
Length = 390
Score = 121 bits (300), Expect = 1e-26
Identities = 114/382 (29%), Positives = 174/382 (44%), Gaps = 58/382 (15%)
Query: 9 APAKIILFGEHSVVYGKPAIASAIDLRTYVR---AEFNDSGNIKIEAHDIKTPGLIVSFS 65
+P K+IL GEH+VVY +PA+A+ + L T +R E + + ++EA + + F+
Sbjct: 8 SPGKVILHGEHAVVYHRPALAAVVGLGTTLRFRQLEDSQVASFQLEALNCTLEIQLPEFN 67
Query: 66 EDKIYFETDY--GKAAEVLSYVRHAIELVLEEA--------------------------- 96
F + Y A +L VR + LE +
Sbjct: 68 GFLAEFRSKYPSDSTANLLEAVRAEVSKQLERSGGNAPKQHTQRAFISIYYLLAGAVLSA 127
Query: 97 --DKR----TGVSVSITSQIPVGAGLGSSAAVAVATIGAVSKLLD--------LELSKEE 142
DK+ TG V + SQ+ VGAGLGSSA+ A L E ++
Sbjct: 128 PGDKKLTLQTGFQVQVDSQLTVGAGLGSSASFGAALATTFLILAGHFDRDSYLSEANQAL 187
Query: 143 IAKMGHKVELLVQGASSGIDPTVSAIGGFLYYKQGE-FEHLPFVE-LPIVVGYTGSSGST 200
I+ ++ E + G SG+D TV GG L Y +G+ F+ L + L I++ + S ST
Sbjct: 188 ISSWAYESERVNHGTPSGLDNTVCTYGGMLRYVKGQGFQSLKIQKPLNILLVDSRVSRST 247
Query: 201 KELVAMVRRRYEEMPELIEPILESMGKLVDKAKEVIIS---KLDEEEKFLKLGELMNINH 257
++VA VR + P+LIE I ++ +LV A + S D+ KF +L L IN+
Sbjct: 248 ADIVAKVRHLGDAFPQLIEAIWQACEELVAAAVPLYESFGNAQDDSSKFEQLERLFQINN 307
Query: 258 GLLDALGVSTKKLSELVYAARTAGAIGAKLTGAGGGGCMYALAPGKQR------EVATAI 311
LL A+GVS KL ++ A G +KLTGAG GG + L P ++ +
Sbjct: 308 DLLKAIGVSHPKLEQIFTIAFKRGFF-SKLTGAGAGGYVIVLLPENYECNEVYWKLKEEL 366
Query: 312 KIAGGTPMITRISKEGLRIEEV 333
+ AG +T EGLR+ +
Sbjct: 367 ESAGFGVHVTTAGGEGLRVSSL 388
>gb|AAG02435.1|AF290091_1 (AF290091) mevalonate kinase [Staphylococcus epidermidis]
Length = 306
Score = 115 bits (286), Expect = 6e-25
Identities = 99/320 (30%), Positives = 146/320 (44%), Gaps = 30/320 (9%)
Query: 1 MPRLVLASAPAKIILFGEHSVVYGKPAIASAIDL-RTYVRAEFNDSGNIKIEAHDIKTPG 59
M R + KIIL GEH+V +G+PAIA + + V E D GN D+
Sbjct: 1 MTRQGYGESTGKIILMGEHAVTFGQPAIAIPFNAGKIKVLIESLDEGNYSSITSDVYD-- 58
Query: 60 LIVSFSEDKIYFETDYGKAAEVLSYVRHAIELVLEEADKRTGVSVSITSQIPVGAGLGSS 119
G + +++ I +E++ + +SV I + +P GLGSS
Sbjct: 59 ----------------GMLYDAPEHLKSIINRFVEKSGVKEPLSVKIQTNLPPSRGLGSS 102
Query: 120 AAVAVATIGAVSKLLDLELSKEEIAKMGHKVELLVQGASSGIDPTVSAIGGFLYYKQGEF 179
AAVAVA + A +D L + + K + E + G SGID +++KQG+
Sbjct: 103 AAVAVAFVRASYDFMDQPLDDKTLIKEANWAEQIAHGKPSGIDTQTIVSNKPVWFKQGQA 162
Query: 180 EHLPFVELP--IVVGYTGSSGSTKELVAMVRRRYEEMPELIEPILESMGKLVDKAKEVII 237
E L ++L +VV TG GSTK+ V V E + +E +G LV A E I
Sbjct: 163 ETLKSLKLNGYMVVIDTGVKGSTKQAVEDVHVLCES--DEYMKYIEHIGTLVHSASESI- 219
Query: 238 SKLDEEEKFLKLGELMNINHGLLDALGVSTKKLSELVYAARTAGAIGAKLTGAGGGGCMY 297
E+ F L ++ N L L VS K+ +L+ + GAI KLTG G GG M
Sbjct: 220 ----EQHDFHHLADIFNACQEDLRHLTVSHDKIEKLLQIGKEHGAIAGKLTGGGRGGSML 275
Query: 298 ALAPGKQ--REVATAIKIAG 315
LA + + + A++ AG
Sbjct: 276 LLAENLKTAKTIVAAVEKAG 295
>dbj|BAB07790.1| (AB037666) mevalonate kinase [Streptomyces sp. CL190]
Length = 345
Score = 112 bits (278), Expect = 5e-24
Identities = 101/318 (31%), Positives = 148/318 (45%), Gaps = 28/318 (8%)
Query: 6 LASAPAKIILFGEHSVVYGKPAIASAIDLRTYVRAEFNDSGNIKIEAHDIK-----TPG- 59
+ A AK IL GEH+VVYG PA+A I T V A S A + TP
Sbjct: 31 IGRAHAKAILLGEHAVVYGAPALALPIPQLT-VTASVGWSSEASDSAGGLSYTMTGTPSR 89
Query: 60 LIVSFSEDKIYFETDYGKAAEVLSYVRHAIELVLEEADKRTGVSVSITSQIPVGAGLGSS 119
+V+ + D ++ T A ++ H ++++L+ A IP G GLGSS
Sbjct: 90 ALVTQASDGLHRLTAEFMARMGVTNAPH-LDVILDGA-------------IPHGRGLGSS 135
Query: 120 AAVAVATIGAVSKLLDLELSKEEIAKMGHKVELLVQGASSGIDPTVSAIGGFLYYKQGEF 179
AA + A A++ L EL++ ++ E + G +SG+D L ++QG
Sbjct: 136 AAGSRAIALALADLFGHELAEHTAYELVQTAENMAHGRASGVDAMTVGASRPLLFQQGRT 195
Query: 180 EHLPF-VELPIVVGYTGSSGSTKELVAMVRRRYEEMPELIEPILESMGKLVDKAKEVIIS 238
E L + +V +G GSTKE V M+R + E + +L + A++ +
Sbjct: 196 ERLAIGCDSLFIVADSGVPGSTKEAVEMLREGFTRSAGTQERFVGRATELTEAARQALAD 255
Query: 239 KLDEEEKFLKLGELMNINHGLLDALGVSTKKLSELVYAARTAGAIGAKLTGAGGGGCMYA 298
EE LG + H LL +ST + LV AA AG++GAK+TG G GGCM A
Sbjct: 256 GRPEE-----LGSQLTYYHELLHEARLSTDGIDALVEAALKAGSLGAKITGGGLGGCMIA 310
Query: 299 LA-PGKQREVATAIKIAG 315
A P + REV + AG
Sbjct: 311 QARPEQAREVTRQLHEAG 328
>gb|AAG02450.1|AF290097_1 (AF290097) mevalonate kinase [Streptococcus pyogenes]
Length = 292
Score = 110 bits (272), Expect = 3e-23
Identities = 91/298 (30%), Positives = 137/298 (45%), Gaps = 41/298 (13%)
Query: 9 APAKIILFGEHSVVYGKPAIASAIDLRTYVRAEFNDSGNIKIEAHDIKTPGLIVSFSEDK 68
A +KIIL GEH+VVYG PAIA + +I++ H
Sbjct: 10 AHSKIILIGEHAVVYGYPAIALPLT-------------DIEVVCH--------------- 41
Query: 69 IYFETDYGKAAEVLSYVRHAIELVLEEADK-RTGVSVSITSQIPVGAGLGSSAAVAVATI 127
F D + + AI L+ + + ++ I SQ+P G+GSSAAV++A I
Sbjct: 42 -IFPADKPLVFDFYDTLSTAIYAALDYLQRLQEPIAYEIVSQVPQKRGMGSSAAVSIAAI 100
Query: 128 GAVSKLLDLELSKEEIAKMGHKVELLVQGASSGID-PTVSAIGGFLYYKQGEFEHLPF-V 185
AV LS + + + +K E++ SG+D T + + + FE + +
Sbjct: 101 RAVFSYCQEPLSDDLLEILVNKAEIIAHTNPSGLDAKTCLSDHAIKFIRNIGFETIEIAL 160
Query: 186 ELPIVVGYTGSSGSTKELVAMVRRRYEEMPELIEPILESMGKLVDKAKEVIISKLDEEEK 245
+++ TG G T+E V + + E P L +G L + I ++
Sbjct: 161 NGYLIIADTGIHGHTREAV----NKVAQFEETNLPYLAKLGALTQALERAI-----NQKN 211
Query: 246 FLKLGELMNINHGLLDALGVSTKKLSELVYAARTAGAIGAKLTGAGGGGCMYALAPGK 303
+ +G+LM H L A+GVS K +LV AA AGA+GAK+TG G GGCM ALA K
Sbjct: 212 KVAIGQLMTQAHSALKAIGVSISKADQLVEAALRAGALGAKMTGGGLGGCMIALADTK 269
>gb|AAG02430.1|AF290089_1 (AF290089) mevalonate kinase [Staphylococcus haemolyticus]
Length = 307
Score = 108 bits (267), Expect = 1e-22
Identities = 94/308 (30%), Positives = 141/308 (45%), Gaps = 27/308 (8%)
Query: 12 KIILFGEHSVVYGKPAIASAIDLRTYVRAEFNDSGNIKIEAHDIKTPGLIVSFSEDKIYF 71
KIIL GEH+V +G+PAIA SG +K+ ++ S + +Y
Sbjct: 12 KIILIGEHAVTFGEPAIAIPFT-----------SGKVKVLIESLEKGNY--SAIQSDVYD 58
Query: 72 ETDYGKAAEVLSYVRHAIELVLEEADKRTGVSVSITSQIPVGAGLGSSAAVAVATIGAVS 131
Y + S + H +E E + + I + +P GLGSSAAVAVA I A
Sbjct: 59 GPLYDAPEHLKSLIGHFVENKKVEEP----LLIKIQANLPPSRGLGSSAAVAVAFIRASY 114
Query: 132 KLLDLELSKEEIAKMGHKVELLVQGASSGIDPTVSAIGGFLYYKQGEFEHLPFVELP--I 189
L L L+ +E+ + E + G SGID ++Y++GE E L ++L +
Sbjct: 115 DYLGLPLTDKELLENADWAERIAHGKPSGIDTKTIVTNQPVWYQKGEVEILKTLDLDGYM 174
Query: 190 VVGYTGSSGSTKELVAMVRRRYEEMPELIEPILESMGKLVDKAKEVIISKLDEEEKFLKL 249
VV TG GSTK+ V V + + ++ +++ +G LV A E I E F +L
Sbjct: 175 VVIDTGVKGSTKQAVEDVHQLCDNDKNYMQ-VVKHIGSLVYSASEAI-----EHHSFDQL 228
Query: 250 GELMNINHGLLDALGVSTKKLSELVYAARTAGAIGAKLTGAGGGGCMYALAPGKQ--REV 307
+ N L L VS K+ + G++ KLTG G GG M LA Q + +
Sbjct: 229 ATIFNQCQDDLRTLTVSHDKIEMFLRLGEENGSVAGKLTGGGRGGSMLILAKELQTAKNI 288
Query: 308 ATAIKIAG 315
A++ AG
Sbjct: 289 VAAVEKAG 296
>gb|AAG02455.1|AF290099_1 (AF290099) mevalonate kinase [Streptococcus pneumoniae]
Length = 292
Score = 92.8 bits (227), Expect = 5e-18
Identities = 87/297 (29%), Positives = 142/297 (47%), Gaps = 41/297 (13%)
Query: 6 LASAPAKIILFGEHSVVYGKPAIASAIDLRTYVRAEFNDSGNIKIEAHDIKTPGLIVSFS 65
+ A +KIIL GEH+VVYG PAI+ + +++E T ++ + S
Sbjct: 7 VGQAHSKIILIGEHAVVYGYPAISLPL---------------LEVEV----TCKVVSAES 47
Query: 66 EDKIYFETDYGKAAEVLSYVRHAIELVLEEAD-KRTGVSVSITSQIPVGAGLGSSAAVAV 124
++Y E + LS A+ LE D V I S IP G+GSSAA+++
Sbjct: 48 PWRLYEE-------DTLSM---AVYASLEYLDITEACVRCEIDSAIPEKRGMGSSAAISI 97
Query: 125 ATIGAVSKLLDLELSKEEIAKMGHKVELLVQGASSGIDP-TVSAIGGFLYYKQGEFEHLP 183
A I AV +L + + + ++ E++ SG+D T + + K F L
Sbjct: 98 AAIRAVFDYYQADLPHDVLEILVNRAEMIAHMNPSGLDAKTCLSDQPIRFIKNVGFTELE 157
Query: 184 F-VELPIVVGYTGSSGSTKELVAMVRRRYEEMPELIEPILESMGKLVDKAKEVIISKLDE 242
+ +V+ TG G T+E + +V+ + ++ P L ++G+L +A+ I K E
Sbjct: 158 MDLSAYLVIADTGVYGHTREAIQVVQNKGKDAL----PFLHALGELTQQAEVAISQKYAE 213
Query: 243 EEKFLKLGELMNINHGLLDALGVSTKKLSELVYAARTAGAIGAKLTGAGGGGCMYAL 299
LG + + H L +GVS+ + LV A + GA+GAK++G G GGC+ AL
Sbjct: 214 G-----LGLIFSQAHLHLKEIGVSSPEADFLVETALSYGALGAKMSGGGLGGCIIAL 265
>gb|AAG28454.1|AF195244_1 (AF195244) galactokinase [Pyrococcus furiosus]
Length = 352
Score = 91.3 bits (223), Expect = 1e-17
Identities = 91/343 (26%), Positives = 150/343 (43%), Gaps = 55/343 (16%)
Query: 5 VLASAPAKIILFGEHSVVYGKPAIASAIDLRTYVRAEFNDSGNIKIEAHDIKTPGLIVSF 64
+ +P ++ L GEH+ + AIDL T + AE D + E F
Sbjct: 4 ITVKSPGRVNLIGEHTDYTYGYVMPMAIDLYTIITAEKYDKVQLYSE-----------HF 52
Query: 65 SEDKIYFETDYGKAAEVLSYVRHAIELVLEEADKRTGVSVSITSQIPVGAGLGSSAAVAV 124
+E+K + + K + YV+ + ++++E K G+ IT +P+GAGL SSA+ V
Sbjct: 53 NEEKTFTLDNLTKEGSWIDYVKGVLWVLIQEGYKIGGLKGKITGDLPLGAGLSSSASFEV 112
Query: 125 ATIGAVSKLLDLELSKEEIAKMGHKVELLVQGASSGIDPTVSAIGG------FLYYKQGE 178
+ +++L +L + + A + K E G GI + + G FL + +
Sbjct: 113 GILEVLNQLYNLNIDPLKKALLAKKAENEFVGVPCGILDQFAVVFGKKDNVIFLDTQTLQ 172
Query: 179 FEHLPF-VELPIVVGYTGSSGSTKELVAMVRRRYEEMPELIEPILESMGKLVDKAKEVII 237
+E++PF ++ ++V YTG +EL + Y E + E L +GK + +KEV
Sbjct: 173 YEYIPFPKDVSVLVFYTGVK---RELAS---SEYAERKRIAEESLRILGK--ESSKEVTE 224
Query: 238 SKLDE----EEKFL-----------------------KLGELMNINH-GLLDALGVSTKK 269
L + KF K+G+++ H L + VS ++
Sbjct: 225 KDLGKLPPLHRKFFSYIVRENARVLEVRDALKEGDIEKVGKILTTAHWDLAENYRVSCEE 284
Query: 270 LSELVYAARTAGAIGAKLTGAGGGGCMYALA-PGKQREVATAI 311
L V A GA GA+LTGAG GG AL K + + AI
Sbjct: 285 LDFFVKKAMELGAYGARLTGAGFGGSAIALVDKDKAKTIGDAI 327
>sp|Q9RGS1|GAL1_STACA GALACTOKINASE (GALACTOSE KINASE)
>gi|6707009|gb|AAF25548.1|AF109295_3 (AF109295) GalK
[Staphylococcus carnosus]
Length = 388
Score = 84.3 bits (205), Expect = 2e-15
Identities = 84/336 (25%), Positives = 150/336 (44%), Gaps = 48/336 (14%)
Query: 5 VLASAPAKIILFGEHSVVYGKPAIASAIDLRTYVRAEFNDSGNIKIEAHDIKTPGLIVSF 64
V A AP +I L GEH+ G +AI+L TY A + I + +++ ++ G I F
Sbjct: 19 VAAFAPGRINLIGEHTDYNGGYVFPAAIELGTYGLASKRNDNKICLYSNNFESTGTI-EF 77
Query: 65 SEDKIYFETDYGKAAEVLSYVRHAIELVLEEADK-RTGVSVSITSQIPVGAGLGSSAAVA 123
S D++ F+T + A +Y + ++ + E + +G ++ I IP GA L SSA++
Sbjct: 78 SLDELQFDTTHSWA----NYPKGMVKFLKESGYQIDSGFNILIEGNIPNGASLSSSASIE 133
Query: 124 VATIGAVSKLLDLELSKEEIAKMGHKVELLVQGASSGI-DPTVSAIGG-----FLYYKQG 177
+ + L +LE+ + E+ ++G KVE G +SGI D + +G L
Sbjct: 134 ILMGWLLKALFNLEVERLELIELGRKVENQFIGVNSGIMDQFIVGMGRKDQAILLDTATL 193
Query: 178 EFEHLPFVELPIVVGYTGSSGSTKELVAMVRRRYEEMPELI-----EPILESMGK----- 227
E+ ++P V+ ++ + + R +E + E ++++G
Sbjct: 194 EYHYVPTEFGDYVISIMNTNKRRELAESKYNERLKECQSALALLQQELDVDALGHIDVTT 253
Query: 228 ------------LVDKAKEVIISKLDEEE--------KFLKLGELMNINHGLL----DAL 263
L+ +A+ I +E F++ G L+N +H L +
Sbjct: 254 FEKHAYLIEEDVLLRRARHAITENARVKEAHAALNRKDFIEFGRLLNASHASLKNDYEVT 313
Query: 264 GVSTKKLSELVYAARTAGAIGAKLTGAGGGGCMYAL 299
G+ L+E A + G +GA++TGAG GC AL
Sbjct: 314 GIELDTLAET--AQQVEGVLGARMTGAGFAGCAIAL 347
>dbj|BAB07819.1| (AB037907) phosphomevalonate kinase [Streptomyces griseolosporeus]
Length = 360
Score = 82.3 bits (200), Expect = 7e-15
Identities = 104/373 (27%), Positives = 156/373 (40%), Gaps = 64/373 (17%)
Query: 2 PRLVLASAPAKIILFGEHSVVY-GKPAIASAIDLRTYVRAEFNDSGNIKIEAHDIKTPGL 60
PR V AP K+ + GE++VV G AI A+D YV +D PG+
Sbjct: 4 PRAVTRRAPGKLFVAGEYAVVEPGNRAILVAVD--RYVTVTVSDGA----------APGV 51
Query: 61 IVS--FSEDKIYFETDYGKAA------EVLSYVRHAIELVLEEADKRTGVSVSITSQIPV 112
+VS ++ G+ V++ V L+ E + SI+S +
Sbjct: 52 VVSSDIGAGPVHHPWQDGRLTGGTGTPHVVAAVETVARLLAERGRSVPPLGWSISSTLHE 111
Query: 113 GA---GLGSSAAVAVATIGAVSKLLDLELSKEEIAKMGHKVELLVQGASSGIDPTVSAIG 169
GLGSS AV VAT+ AV+ LEL+ EE + + SG D S G
Sbjct: 112 DGRKFGLGSSGAVTVATVSAVAAHCGLELTAEERFRTALIASARIDPRGSGGDIATSTWG 171
Query: 170 GFLYY-------------KQGEFEHL------------PFVELPIVVGYTGSSGSTKELV 204
G++ Y +QG E L P L + VG+TG+ ST L+
Sbjct: 172 GWIAYRAPDRDAVLDLTRRQGVDEALRAPWPGFSVRLSPPRNLCLEVGWTGNPVSTTSLL 231
Query: 205 AMVRRRYEEMPELIEPILESMGKLVDKAKEVIISKLDEEEKFLKLGELMNINHGLLD--- 261
+ RR + + G+LVD A +I+ D + + L L ++ H ++
Sbjct: 232 TDLHRRTWRGSPAYRRYVGATGELVDAA---VIALEDGDTEGL-LRQVRRARHEMVRLDD 287
Query: 262 --ALGVSTKKLSELVYAARTAGAIGAKLTGAGGGGCMYALAPGKQREVATAI----KIAG 315
LG+ T +L+ L A AGA AK +GAGGG C AL + R + + AG
Sbjct: 288 EVGLGIFTPELTALCAIAERAGA--AKPSGAGGGDCGIALLDAEARYDRSPLHRQWAAAG 345
Query: 316 GTPMITRISKEGL 328
P++ + EG+
Sbjct: 346 VLPLLVSPATEGV 358
>sp|O58107|GAL1_PYRHO PROBABLE GALACTOKINASE (GALACTOSE KINASE) >gi|7434202|pir||F71144
probable galactokinase - Pyrococcus horikoshii
>gi|3256760|dbj|BAA29443.1| (AP000002) 350aa long
hypothetical galactokinase [Pyrococcus horikoshii]
Length = 350
Score = 80.4 bits (195), Expect = 3e-14
Identities = 90/337 (26%), Positives = 144/337 (42%), Gaps = 52/337 (15%)
Query: 4 LVLASAPAKIILFGEHSVVYGKPAIASAIDLRTYVRAEFNDSGNIKIEAHDIKTPGLIVS 63
++ +P ++ L GEH+ + AI+L T + AE + + E
Sbjct: 1 MIKVKSPGRVNLIGEHTDYTYGYVMPMAINLYTKIEAEKHGEVILYSE-----------H 49
Query: 64 FSEDKIYFETDYGKAAEVLSYVRHAIELVLEEADKRTG-VSVSITSQIPVGAGLGSSAAV 122
F E++ + D K + YV+ I VL+E+D G + ++ +P+GAGL SSA+
Sbjct: 50 FGEERKFSLNDLRKENSWIDYVK-GIFWVLKESDYEVGGIKGRVSGNLPLGAGLSSSASF 108
Query: 123 AVATIGAVSKLLDLELSKEEIAKMGHKVELLVQGASSGIDPTVSAIGG------FLYYKQ 176
V + + KL +L+L + K E G GI + + G FL
Sbjct: 109 EVGILETLDKLYNLKLDSLSKVLLAKKAENEFVGVPCGILDQFAVVFGREGNVIFLDTHT 168
Query: 177 GEFEHLPF-VELPIVVGYTGSSGSTKELVAMVRRRYEEMPELIEPILESMGKLVDK-AKE 234
++E++PF ++ I+V YT G +EL + Y E + E L+ +GK K +E
Sbjct: 169 LDYEYIPFPKDVSILVFYT---GVRRELAS---SEYAERKHIAEESLKILGKGSSKEVRE 222
Query: 235 VIISKLD------------------------EEEKFLKLGELMNINH-GLLDALGVSTKK 269
+SKL +E ++G+++ H L VS K+
Sbjct: 223 GELSKLPPLHRKFFGYIVRENARVLEVRDALKEGNVEEVGKILTTAHWDLAKNYEVSCKE 282
Query: 270 LSELVYAARTAGAIGAKLTGAGGGGCMYALAPGKQRE 306
L V A GA GA+LTGAG GG AL + E
Sbjct: 283 LDFFVERALKLGAYGARLTGAGFGGSAIALVDKEDAE 319
>sp|O85253|GAL1_THENE GALACTOKINASE (GALACTOSE KINASE) >gi|3252901|gb|AAC24222.1|
(AF055482) galactose kinase [Thermotoga neapolitana]
Length = 350
Score = 74.9 bits (181), Expect = 1e-12
Identities = 87/321 (27%), Positives = 140/321 (43%), Gaps = 42/321 (13%)
Query: 9 APAKIILFGEHSVVYGKPAIASAIDLRTYVRAEFNDSGNIKIEAHDIKTPGLIVSFSEDK 68
AP +I + GEH+ + A++ ++ E DSG K H + +K
Sbjct: 5 APGRINIIGEHTDYNDGYVLPFAVNRFVFLTIE--DSG--KFVFHSENMNETVEMEKIEK 60
Query: 69 IYFETDYGKAAEVLSYVRHAIELVLEEADKRTGVSVSITSQIPVGAGLGSSAAVAVATIG 128
+ TDY +S V A E + K + V +S++S +P+GAGL SSAA+ +AT
Sbjct: 61 LNRWTDY------ISGVIKAFE---KRGYKVSPVKISVSSNLPMGAGLSSSAALEMATAY 111
Query: 129 AVSKLLDLELSKEEIAKMGHKVELLVQGASSGI-DPTVSAIGG-----FLYYKQGEFEHL 182
A+S+ L K E+ K+ + E+ G GI D SA G FL E+E++
Sbjct: 112 AISEHFGFHLPKLELVKIAREAEVEFVGVRCGIMDQFTSAFGKKDHAIFLDTMTLEYEYV 171
Query: 183 PFVELPIVVGYTGSSGSTKELVAMVRRRYEEMPELI---------EPILESMGKLVDKAK 233
P + S+ + + +R +E E++ E E + KL D K
Sbjct: 172 PLKLEGYEINLVDSNVKHELSSSEYNKRRQECEEVLRVLGKRSFREVTKEDLKKLPDVLK 231
Query: 234 EVIISKLDEEEKFLK------------LGELMNINH-GLLDALGVSTKKLSELV-YAART 279
+ L+E E+ LK LG L+ +H L D VS ++ +V +
Sbjct: 232 KRAQHVLEENERVLKSVQALKEGDFETLGRLLFSSHESLRDLYEVSCEQTDFIVDFLKGR 291
Query: 280 AGAIGAKLTGAGGGGCMYALA 300
G +GA++ G G GG + L+
Sbjct: 292 EGILGARMVGGGFGGGVIVLS 312
>pir||G70185 mevalonate kinase homolog - Lyme disease spirochete
>gi|2688613|gb|AAC67029.1| (AE001169) mevalonate kinase
[Borrelia burgdorferi]
Length = 297
Score = 73.7 bits (178), Expect = 3e-12
Identities = 72/294 (24%), Positives = 124/294 (41%), Gaps = 41/294 (13%)
Query: 10 PAKIILFGEHSVVYGKPAIASAIDLRTYVRAEFNDSGNIKIEAHDIKTPGLIVSFSEDKI 69
PAKI+ GEHS VYG P I + + + LI S S++
Sbjct: 7 PAKILFLGEHSAVYGFPVIGATVPIYM----------------------DLIYSVSKNWK 44
Query: 70 YFETDYGKAAEVLSYVRHAIELVLEEADKRTGVSVSITSQIPVGAGLGSSAAVAVATIGA 129
Y GK + L+ + I ++ K + I S+IP+G GLGSSA++++
Sbjct: 45 YL----GKPSTRLNSL---ISFIVSNYSKVNPIEFDIISEIPIGVGLGSSASLSLCFAEY 97
Query: 130 VSKLLDLELSKEEIAKMGHKVELLVQGASSGIDPTVSAIGGFLYYKQGE----FEHLPFV 185
++ + + + + + +++E + G SSG+D + + G Y ++ E + +
Sbjct: 98 ITSHFEYKDCNKIL--LANQIENIFHGKSSGMDIRLIDLNGTFYLEKKENVLHSKKIKDS 155
Query: 186 ELPIVVGYTGSSGSTKELVAMVRRRYEEMPELIEPILESMGKLVDKAKEVIISKLDEEEK 245
++G +TKE+V +++ L +E +G V + + +
Sbjct: 156 GFYFLIGAIKRDLTTKEIVVNLKKDLLSNAYLF-VFIEKLGLAVSNSYASF-----QNKD 209
Query: 246 FLKLGELMNINHGLLDALGVSTKKLSELVYAARTAGAIGAKLTGAGGGGCMYAL 299
L MNI L LG+S L L+ GA+ KL+GAG GG L
Sbjct: 210 VYSLANEMNIAQCCLKRLGLSNDTLDWLISEGIKLGALSGKLSGAGKGGAFIFL 263
>gb|AAK43093.1| (Phospho) mevalonate kinase, putative [Sulfolobus solfataricus]
Length = 323
Score = 72.6 bits (175), Expect = 6e-12
Identities = 90/350 (25%), Positives = 149/350 (41%), Gaps = 51/350 (14%)
Query: 4 LVLASAPAKIILFGEHSVVYGKPAIASAIDLRTYVRAEFNDSGNIKIEAHDIKTPGLIVS 63
++ SAP KI+ G +SVV+G + A++ R + +IK
Sbjct: 1 MIKVSAPGKILWIGSYSVVFGGISHVIAVNKR------------VSCSLREIK------- 41
Query: 64 FSEDKIYFETDYG----KAAEVLSYVRHAIELVLEEADKRTGVSVSITSQIPVGA---GL 116
+D + F T YG E+++ V L + + + + + + GL
Sbjct: 42 -EKDSLIFHTSYGHFKNSGNELINSVLDTFRERLSQLPQGYEIDLYNDKEFIIDGKKTGL 100
Query: 117 GSSAAVAVATIGAVSKLLDLELSKEEIAKMGHKVELLVQ-GASSGIDPTVSAIGGFLYYK 175
GSS+A V+ + + +L EI K+ Q G SG D SA+ G + YK
Sbjct: 101 GSSSAATVSLTACLYYAIHGKLDLFEIHKLAQIANYKRQKGIGSGFD-IASAVFGSIVYK 159
Query: 176 QGE--------FEHLPFVELPIVVGYTGSSGSTKELVAMVRRRYEEMPELIEPILESMGK 227
+ FE L +++G+TG S T LV R++ E L + + + +
Sbjct: 160 RFTDLDKMDFYFEKLNLGNYDMMLGFTGKSSETVGLV----RKFVEKSNLDD--FKEIMR 213
Query: 228 LVDKA-----KEVIISKLDEEEKFLKLG-ELMNINHGLLDALGVSTKKLSELVYAARTAG 281
L+D+ K + ++KLDE + +KLG + +N + + + +K EL+ A G
Sbjct: 214 LIDEENYMAIKLIKLNKLDEAVEHIKLGRKYLNYIAERIVGVKLVSKMEEELIKIAEEEG 273
Query: 282 AIGAKLTGAGGGGCMYALAPGKQREVATAIKIAGGTPMITRISKEGLRIE 331
A+ A GAGGG ++AL R K G +I EGLR+E
Sbjct: 274 ALVALSPGAGGGDSIFALGNDLNRVREAWSK--RGIFIIDVKEDEGLRLE 321
>sp|P56838|GAL1_THEMA GALACTOKINASE >gi|7434204|pir||C72283 galactokinase - Thermotoga
maritima (strain MSB8)
>gi|4981741|gb|AAD36265.1|AE001776_1 (AE001776)
galactokinase [Thermotoga maritima]
Length = 350
Score = 72.2 bits (174), Expect = 8e-12
Identities = 80/325 (24%), Positives = 138/325 (41%), Gaps = 50/325 (15%)
Query: 9 APAKIILFGEHSVVYGKPAIASAIDLRTYVRAEFNDSGNIKIEAHDIKTPGLIVSFSEDK 68
AP +I + GEH+ + A++ ++ E G+ + H + +K
Sbjct: 5 APGRINIIGEHTDYNDGYVLPFAVNRYVFLSIE----GSERFIFHSENVNETVEMEKIEK 60
Query: 69 IYFETDYGKAAEVLSYVRHAIELVLEEADKR----TGVSVSITSQIPVGAGLGSSAAVAV 124
+ TDY I V+ +KR + V +S++S +P+GAGL SSAA+ V
Sbjct: 61 LNKWTDY-------------ISGVIASFEKRGYRVSPVKISVSSNLPIGAGLSSSAALEV 107
Query: 125 ATIGAVSKLLDLELSKEEIAKMGHKVELLVQGASSGIDPTVSAIGG------FLYYKQGE 178
AT A+S+ + K E+ K+ + E+ G GI +A+ G FL E
Sbjct: 108 ATAYAISEYFGFNVPKLELVKIAREAEVEFVGVRCGIMDQFTAVFGKKDHAIFLDTMTLE 167
Query: 179 FEHLPFVELPIVVGYTGSSGSTKELVAMVRRRYEEMPELI---------EPILESMGKLV 229
+E++P + S+ + + RR +E E++ E E + +L
Sbjct: 168 YEYVPLKLEGYEINLVDSNVKHELSSSEYNRRRQECEEVLKTLEKKSFREVTKEDLERLS 227
Query: 230 DKAKEVIISKLDEEEKFLK------------LGELMNINH-GLLDALGVSTKKLSELV-Y 275
++ L+E E+ LK LG+L+ +H L D VS ++ +V Y
Sbjct: 228 GTLRKRAQHVLEENERVLKSVQALKEGDFETLGKLLFSSHESLRDLYEVSCEETDFIVDY 287
Query: 276 AARTAGAIGAKLTGAGGGGCMYALA 300
G +GA++ G G GG + L+
Sbjct: 288 LRGKEGILGARMVGGGFGGGVIVLS 312
>gb|AAG02447.1|AF290095_3 (AF290095) phosphomevalonate kinase [Enterococcus faecium]
Length = 361
Score = 72.2 bits (174), Expect = 8e-12
Identities = 89/335 (26%), Positives = 150/335 (44%), Gaps = 56/335 (16%)
Query: 4 LVLASAPAKIILFGEHSVVY-GKPAIASAIDLRTYVRAEF-NDSGNIKIEAHDIKTPGLI 61
++ SAP K+ + GE++VV G PA+ +A+D V E G+I+ + G+
Sbjct: 1 MIEVSAPGKLYIAGEYAVVETGHPAVIAAVDQFVTVTVESARKVGSIQSAQYS----GMP 56
Query: 62 VSFSEDKIYFETDYGKAAEVLSYVRHAIELVLEEADKRTGV----SVSITSQIPVGAG-- 115
V ++ D + Y+ AI L + A ++ + + +TS++ G
Sbjct: 57 VRWTRRNGELVLDIRE--NPFHYILAAIRLTEKYAQEKNILLSFYDLKVTSELDSSNGRK 114
Query: 116 --LGSSAAVAVATIGAVSKLLDLELSKEEIAKMGHKVELLVQGASSGIDPTVSAIGGFLY 173
LGSS AV VAT+ A++ L LS+ EI K+ L VQ S D S GG++
Sbjct: 115 YGLGSSGAVTVATVKALNVFYALNLSQLEIFKIAALANLAVQDNGSCGDIAASCYGGWIA 174
Query: 174 Y--------KQGEFEHL---------------PFV---ELPIVVGYTGSSGSTKELVAMV 207
+ ++ E +H P + +L +++G+TGS ST +LV V
Sbjct: 175 FSTFDHPWLQEQETQHSISELLALDWPGLSIEPLIAPEDLRLLIGWTGSPASTSDLVDQV 234
Query: 208 RRRYEEMPELIEPILESMGKLVDKAKEVIISKLDEEEKFLKLGELMNINHGLLDALG--- 264
R E+ + L++ + V++ + K +E + +++ N LL L
Sbjct: 235 HRSREDKMVAYQLFLKNSTECVNE-----MIKGFKENNVTLIQQMIRKNRQLLHDLSAIT 289
Query: 265 ---VSTKKLSELV-YAARTAGAIGAKLTGAGGGGC 295
+ T L++L A + GA AK +GAGGG C
Sbjct: 290 GVVIETPALNKLCNLAEQYEGA--AKSSGAGGGDC 322
>gb|AAG02426.1|AF290087_3 (AF290087) phosphomevalonate kinase [Staphylococcus aureus]
Length = 358
Score = 71.4 bits (172), Expect = 1e-11
Identities = 84/330 (25%), Positives = 143/330 (42%), Gaps = 44/330 (13%)
Query: 4 LVLASAPAKIILFGEHSVVY-GKPAIASAIDLRTYVRAEFNDSGNIKIEAHDIKTPGLIV 62
++ AP K+ + GE++V G ++ A+D +V A ++ K H V
Sbjct: 1 MIQVKAPGKLYIAGEYAVTEPGYKSVLIALD--RFVTATIEEATQYKGTIHSKALHHNPV 58
Query: 63 SFSEDKIYFETDYGKAAEVLSYVRHAIELVLEEADKRTGVSV-----SITSQIPVGAG-- 115
+FS D+ AA+ L+YV AIE + E+ K +++ +I S + G
Sbjct: 59 TFSRDEDSIVISDPHAAKQLNYVVTAIE-IFEQYAKSCDIAMKHFHLTIDSNLDDSNGHK 117
Query: 116 --LGSSAAVAVATIGAVSKLLDLELSKEEIAKMGHKVELLVQGASSGIDPTVSAIGGFLY 173
LGSSAAV V+ I +++ D++LS I K+ + +Q SS D VS G+L
Sbjct: 118 YGLGSSAAVLVSVIKVLNEFYDMKLSNLYIYKLAVIANMKLQSLSSCGDIAVSVYSGWLA 177
Query: 174 YKQGEFE----------------------HLPFVELP----IVVGYTGSSGSTKELVAMV 207
Y + E H+ ++ P +++G+TGS S+ V+ V
Sbjct: 178 YSTFDHEWVKHQIEDTTVEEVLIKNWPGLHIEPLQAPENMEVLIGWTGSPASSPHFVSEV 237
Query: 208 RRRYEEMPELIEPILESMGKLVDKAKEVI-ISKLDEEEKFLKLGELMNINHGLLDALGVS 266
+R + P LE + V+K + + +K ++ + + +
Sbjct: 238 KRLKSD-PSFYGDFLEDSHRCVEKLIHAFKTNNIKGVQKMVRQNRTIIQRMDKEATVDIE 296
Query: 267 TKKLSELV-YAARTAGAIGAKLTGAGGGGC 295
T+KL L A + GA +K +GAGGG C
Sbjct: 297 TEKLKYLCDIAEKYHGA--SKTSGAGGGDC 324
>gb|AAG02437.1|AF290091_3 (AF290091) phosphomevalonate kinase [Staphylococcus epidermidis]
Length = 358
Score = 70.2 bits (169), Expect = 3e-11
Identities = 80/329 (24%), Positives = 142/329 (42%), Gaps = 42/329 (12%)
Query: 4 LVLASAPAKIILFGEHSVVYGKPAIASA-IDLRTYVRAEFNDSGNIKIEAHDIKTPGLIV 62
++ AP K+ + GE++V +P S I + +V A S ++ H V
Sbjct: 1 MIQVKAPGKLYIAGEYAVT--EPGYKSILIAVNRFVTATIEASNKVEGSIHSKTLHYEPV 58
Query: 63 SFSEDKIYFETDYGKAAEVLSYVRHAIELVLEEADKRTGVSV-----SITSQIPVGAG-- 115
F ++ E +AA+ L YV AIE V E+ + +++ +I S + +G
Sbjct: 59 KFDRNEDRIEISDVQAAKQLKYVVTAIE-VFEQYVRSCNMNLKHFHLTIDSNLADNSGQK 117
Query: 116 --LGSSAAVAVATIGAVSKLLDLELSKEEIAKMGHKVELLVQGASSGIDPTVSAIGGFLY 173
LGSSAAV V+ + A+++ LELS I K+ + +Q SS D VS G+L
Sbjct: 118 YGLGSSAAVLVSVVKALNEFYGLELSNLYIYKLAVIANMKLQSLSSCGDIAVSVYSGWLA 177
Query: 174 YKQGEFE----------------------HLPFVELP----IVVGYTGSSGSTKELVAMV 207
Y + + H+ ++ P +++G+TGS S+ LV+ V
Sbjct: 178 YSTFDHDWVKQQMEETSVNDVLEKNWPGLHIEPLQAPENMEVLIGWTGSPASSPHLVSEV 237
Query: 208 RRRYEEMPELIEPILESMGKLVDKAKEVI-ISKLDEEEKFLKLGELMNINHGLLDALGVS 266
+R + P L+ V+ + + + +K +++ + + ++ +
Sbjct: 238 KRLKSD-PSFYGDFLDQSHACVESLIQAFKTNNIKGVQKMIRINRRIIQSMDNEASVEIE 296
Query: 267 TKKLSELVYAARTAGAIGAKLTGAGGGGC 295
T KL +L G +K +GAGGG C
Sbjct: 297 TDKLKKLCDVGEKHGG-ASKTSGAGGGDC 324
>gb|AAG02432.1|AF290089_3 (AF290089) phosphomevalonate kinase [Staphylococcus haemolyticus]
Length = 358
Score = 69.5 bits (167), Expect = 5e-11
Identities = 83/335 (24%), Positives = 143/335 (41%), Gaps = 46/335 (13%)
Query: 4 LVLASAPAKIILFGEHSVVY-GKPAIASAIDLRTYVRAEFNDSGNIKIEAHDIKTPGLIV 62
++ AP K+ + GE++V G ++ A+D E +++ I + + +
Sbjct: 1 MIQVKAPGKLYVAGEYAVTEPGYKSVLIAVDRFVTASIEASNAVTSTIHSKTLHYEPVTF 60
Query: 63 SFSEDKIYFETDYGKAAEVLSYVRHAIELVLEEADKRTGVSVS-----ITSQIPVGAG-- 115
+ +EDKI + AA L YV AIE V E+ + V + I S + +G
Sbjct: 61 NRNEDKI--DISDANAASQLKYVVTAIE-VFEQYARSCNVKLKHFHLEIDSNLDDASGNK 117
Query: 116 --LGSSAAVAVATIGAVSKLLDLELSKEEIAKMGHKVELLVQGASSGIDPTVSAIGGFLY 173
LGSSAAV V+ + A+++ D++LS I K+ + +Q SS D VS G+L
Sbjct: 118 YGLGSSAAVLVSVVKALNEFYDMQLSNLYIYKLAVISNMRLQSLSSCGDIAVSVYSGWLA 177
Query: 174 YKQGEFE----------------------HLPFVELP----IVVGYTGSSGSTKELVAMV 207
Y + + H+ ++ P +++G+TGS S+ LV+ V
Sbjct: 178 YSTFDHDWVKQQMEETSVNEVLEKNWPGLHIEPLQAPENMEVLIGWTGSPASSPHLVSEV 237
Query: 208 RRRYEEMPELIEPILESMGKLVDKAKEVIISKLDE---EEKFLKLGELMNINHGLLDALG 264
+R + P L+ V+ + K D +K ++ ++ +
Sbjct: 238 KRLKSD-PSFYGRFLDQSHTCVENL--IYAFKTDNIKGVQKMIRQNRMIIQQMDNEATVD 294
Query: 265 VSTKKLSELVYAARTAGAIGAKLTGAGGGGCMYAL 299
+ T+ L L GA AK +GAGGG C A+
Sbjct: 295 IETENLKMLCDIGERYGA-AAKTSGAGGGDCGIAI 328
Database: ./suso.pep
Posted date: Jul 6, 2001 5:57 PM
Number of letters in database: 840,471
Number of sequences in database: 2977
Database: /banques/blast2/nr.pep
Posted date: Dec 14, 2000 12:46 PM
Number of letters in database: 188,266,275
Number of sequences in database: 595,510
Lambda K H
0.315 0.135 0.365
Gapped
Lambda K H
0.270 0.0470 0.230
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 114854776
Number of Sequences: 2977
Number of extensions: 4726031
Number of successful extensions: 14356
Number of sequences better than 1.0e-10: 40
Number of HSP's better than 0.0 without gapping: 8
Number of HSP's successfully gapped in prelim test: 32
Number of HSP's that attempted gapping in prelim test: 14247
Number of HSP's gapped (non-prelim): 57
length of query: 335
length of database: 189,106,746
effective HSP length: 61
effective length of query: 274
effective length of database: 152,599,039
effective search space: 41812136686
effective search space used: 41812136686
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 42 (22.0 bits)
S2: 165 (68.7 bits)