BLASTP 2.0.10 [Aug-26-1999]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= PAB0372 (mvk) DE:mevalonate kinase (mvk)
         (335 letters)

Database: ./suso.pep; /banques/blast2/nr.pep
           598,487 sequences; 189,106,746 total letters

Searching..................................................done

                                                                   Score     E
Sequences producing significant alignments:                        (bits)  Value

sp|Q9V187|KIME_PYRAB MEVALONATE KINASE (MK) >gi|7519971|pir||H75...   647  0.0
sp|O59291|KIME_PYRHO MEVALONATE KINASE (MK) >gi|7521211|pir||A71...   596  e-169
gb|AAG19529.1| (AE005044) mevalonate kinase; Mvk [Halobacterium ...   199  4e-50
sp|Q50559|KIME_METTH MEVALONATE KINASE (MK) >gi|1184118|gb|AAA87...   189  3e-47
pir||B69160 mevalonate kinase - Methanobacterium thermoautotroph...   187  1e-46
gb|AAK40711.1| Mevalonate kinase [Sulfolobus solfataricus]            171  7e-42
gi|11499870 mevalonate kinase (mvk) [Archaeoglobus fulgidus] >gi...   168  1e-40
sp|Q58487|KIME_METJA MEVALONATE KINASE (MK) >gi|2129120|pir||F64...   146  3e-34
gi|4557769 mevalonate kinase [Homo sapiens] >gi|417215|sp|Q03426...   133  3e-30
emb|CAA53059.1| (X75311) ORF for viral-cellular fusion transcrip...   133  3e-30
gi|11436567 mevalonate kinase [Homo sapiens]                          133  3e-30
gb|AAG02445.1|AF290095_1 (AF290095) mevalonate kinase [Enterococ...   132  5e-30
sp|P17256|KIME_RAT MEVALONATE KINASE (MK) >gi|111959|pir||A35629...   131  1e-29
sp|Q9Y946|KIME_AERPE MEVALONATE KINASE (MK) >gi|7521212|pir||F72...   131  2e-29
sp|Q9R008|KIME_MOUSE MEVALONATE KINASE (MK) >gi|6006984|gb|AAF00...   127  2e-28
gb|AAG02424.1|AF290087_1 (AF290087) mevalonate kinase [Staphyloc...   126  4e-28
gb|AAG02440.1|AF290093_1 (AF290093) mevalonate kinase [Enterococ...   126  4e-28
sp|Q09780|KIME_SCHPO PUTATIVE MEVALONATE KINASE (MK) >gi|2117774...   126  4e-28
gi|6323864 mevalonate kinase; Erg12p [Saccharomyces cerevisiae] ...   125  7e-28
gb|AAD45421.1|L77688_1 (L77688) mevalonate kinase [Arabidopsis t...   125  9e-28
sp|P46086|KIME_ARATH MEVALONATE KINASE (MK) >gi|541880|pir||S420...   123  3e-27
dbj|BAB07817.1| (AB037907) mevalonate kinase [Streptomyces grise...   123  3e-27
gb|AAF58481.1| (AE003821) CG16804 gene product [Drosophila melan...   121  1e-26
gb|AAG02435.1|AF290091_1 (AF290091) mevalonate kinase [Staphyloc...   115  6e-25
dbj|BAB07790.1| (AB037666) mevalonate kinase [Streptomyces sp. C...   112  5e-24
gb|AAG02450.1|AF290097_1 (AF290097) mevalonate kinase [Streptoco...   110  3e-23
gb|AAG02430.1|AF290089_1 (AF290089) mevalonate kinase [Staphyloc...   108  1e-22
gb|AAG02455.1|AF290099_1 (AF290099) mevalonate kinase [Streptoco...    93  5e-18
gb|AAG28454.1|AF195244_1 (AF195244) galactokinase [Pyrococcus fu...    91  1e-17
sp|Q9RGS1|GAL1_STACA GALACTOKINASE (GALACTOSE KINASE) >gi|670700...    84  2e-15
dbj|BAB07819.1| (AB037907) phosphomevalonate kinase [Streptomyce...    82  7e-15
sp|O58107|GAL1_PYRHO PROBABLE GALACTOKINASE (GALACTOSE KINASE) >...    80  3e-14
sp|O85253|GAL1_THENE GALACTOKINASE (GALACTOSE KINASE) >gi|325290...    75  1e-12
pir||G70185 mevalonate kinase homolog - Lyme disease spirochete ...    74  3e-12
gb|AAK43093.1| (Phospho) mevalonate kinase, putative [Sulfolobus...    73  6e-12
sp|P56838|GAL1_THEMA GALACTOKINASE >gi|7434204|pir||C72283 galac...    72  8e-12
gb|AAG02447.1|AF290095_3 (AF290095) phosphomevalonate kinase [En...    72  8e-12
gb|AAG02426.1|AF290087_3 (AF290087) phosphomevalonate kinase [St...    71  1e-11
gb|AAG02437.1|AF290091_3 (AF290091) phosphomevalonate kinase [St...    70  3e-11
gb|AAG02432.1|AF290089_3 (AF290089) phosphomevalonate kinase [St...    69  5e-11

>sp|Q9V187|KIME_PYRAB MEVALONATE KINASE (MK) >gi|7519971|pir||H75172 mevalonate kinase
           (mvk) PAB0372 - Pyrococcus abyssi (strain Orsay)
           >gi|5457973|emb|CAB49463.1| (AJ248284) mevalonate kinase
           (mvk) [Pyrococcus abyssi]
           Length = 335
           
 Score =  647 bits (1650), Expect = 0.0
 Identities = 335/335 (100%), Positives = 335/335 (100%)

Query: 1   MPRLVLASAPAKIILFGEHSVVYGKPAIASAIDLRTYVRAEFNDSGNIKIEAHDIKTPGL 60
           MPRLVLASAPAKIILFGEHSVVYGKPAIASAIDLRTYVRAEFNDSGNIKIEAHDIKTPGL
Sbjct: 1   MPRLVLASAPAKIILFGEHSVVYGKPAIASAIDLRTYVRAEFNDSGNIKIEAHDIKTPGL 60

Query: 61  IVSFSEDKIYFETDYGKAAEVLSYVRHAIELVLEEADKRTGVSVSITSQIPVGAGLGSSA 120
           IVSFSEDKIYFETDYGKAAEVLSYVRHAIELVLEEADKRTGVSVSITSQIPVGAGLGSSA
Sbjct: 61  IVSFSEDKIYFETDYGKAAEVLSYVRHAIELVLEEADKRTGVSVSITSQIPVGAGLGSSA 120

Query: 121 AVAVATIGAVSKLLDLELSKEEIAKMGHKVELLVQGASSGIDPTVSAIGGFLYYKQGEFE 180
           AVAVATIGAVSKLLDLELSKEEIAKMGHKVELLVQGASSGIDPTVSAIGGFLYYKQGEFE
Sbjct: 121 AVAVATIGAVSKLLDLELSKEEIAKMGHKVELLVQGASSGIDPTVSAIGGFLYYKQGEFE 180

Query: 181 HLPFVELPIVVGYTGSSGSTKELVAMVRRRYEEMPELIEPILESMGKLVDKAKEVIISKL 240
           HLPFVELPIVVGYTGSSGSTKELVAMVRRRYEEMPELIEPILESMGKLVDKAKEVIISKL
Sbjct: 181 HLPFVELPIVVGYTGSSGSTKELVAMVRRRYEEMPELIEPILESMGKLVDKAKEVIISKL 240

Query: 241 DEEEKFLKLGELMNINHGLLDALGVSTKKLSELVYAARTAGAIGAKLTGAGGGGCMYALA 300
           DEEEKFLKLGELMNINHGLLDALGVSTKKLSELVYAARTAGAIGAKLTGAGGGGCMYALA
Sbjct: 241 DEEEKFLKLGELMNINHGLLDALGVSTKKLSELVYAARTAGAIGAKLTGAGGGGCMYALA 300

Query: 301 PGKQREVATAIKIAGGTPMITRISKEGLRIEEVRE 335
           PGKQREVATAIKIAGGTPMITRISKEGLRIEEVRE
Sbjct: 301 PGKQREVATAIKIAGGTPMITRISKEGLRIEEVRE 335


>sp|O59291|KIME_PYRHO MEVALONATE KINASE (MK) >gi|7521211|pir||A71042 probable mevalonate
           kinase - Pyrococcus horikoshii
           >gi|3258054|dbj|BAA30737.1| (AP000006) 335aa long
           hypothetical mevalonate kinase [Pyrococcus horikoshii]
           Length = 335
           
 Score =  596 bits (1520), Expect = e-169
 Identities = 301/333 (90%), Positives = 322/333 (96%)

Query: 1   MPRLVLASAPAKIILFGEHSVVYGKPAIASAIDLRTYVRAEFNDSGNIKIEAHDIKTPGL 60
           M + VLASAPAK+ILFGEHSVVYGKPAIASAI+LRTYVRA+FNDSGNIKIEAHDIKTPGL
Sbjct: 1   MVKYVLASAPAKVILFGEHSVVYGKPAIASAIELRTYVRAQFNDSGNIKIEAHDIKTPGL 60

Query: 61  IVSFSEDKIYFETDYGKAAEVLSYVRHAIELVLEEADKRTGVSVSITSQIPVGAGLGSSA 120
           IVSFSEDKIYFETDYGKAAEVLSYVR+AIEL LEE+DKR G+ VSITSQIPVGAGLGSSA
Sbjct: 61  IVSFSEDKIYFETDYGKAAEVLSYVRYAIELALEESDKRVGIDVSITSQIPVGAGLGSSA 120

Query: 121 AVAVATIGAVSKLLDLELSKEEIAKMGHKVELLVQGASSGIDPTVSAIGGFLYYKQGEFE 180
           AVAVATIGAVS+LL LELSKEEIAK+GHKVELLVQGASSGIDPTVSA+GGFLYYKQG+FE
Sbjct: 121 AVAVATIGAVSRLLGLELSKEEIAKLGHKVELLVQGASSGIDPTVSAVGGFLYYKQGKFE 180

Query: 181 HLPFVELPIVVGYTGSSGSTKELVAMVRRRYEEMPELIEPILESMGKLVDKAKEVIISKL 240
            LPF+ELPIVVGYTGS+GSTKELVAMVR+RYEEMPEL+EPILE+MGKLVDKAKE+I+SKL
Sbjct: 181 PLPFMELPIVVGYTGSTGSTKELVAMVRKRYEEMPELVEPILEAMGKLVDKAKEIILSKL 240

Query: 241 DEEEKFLKLGELMNINHGLLDALGVSTKKLSELVYAARTAGAIGAKLTGAGGGGCMYALA 300
           DEEEK  KLGELMNINHGLLDALGVSTKKL ELVYAARTAGAIGAKLTGAGGGGCMYALA
Sbjct: 241 DEEEKLTKLGELMNINHGLLDALGVSTKKLGELVYAARTAGAIGAKLTGAGGGGCMYALA 300

Query: 301 PGKQREVATAIKIAGGTPMITRISKEGLRIEEV 333
           PG+QREVATAIKIAGG PMITR+S+EGLRIEEV
Sbjct: 301 PGRQREVATAIKIAGGIPMITRVSREGLRIEEV 333


>gb|AAG19529.1| (AE005044) mevalonate kinase; Mvk [Halobacterium sp. NRC-1]
           Length = 330
           
 Score =  199 bits (501), Expect = 4e-50
 Identities = 131/337 (38%), Positives = 185/337 (54%), Gaps = 23/337 (6%)

Query: 7   ASAPAKIILFGEHSVVYGKPAIASAIDLRTYVRAEFNDSGNIKIEAHDIKTPGLIVSFSE 66
           +SAP K+ LFGEH+VVYG+PA+  AI+ R +V     +   +++ + D+   G  V +S 
Sbjct: 5   SSAPGKVYLFGEHAVVYGEPAVPCAIERRAHVTVSEREDSRLRVCSGDLSIDGFTVEYSG 64

Query: 67  DKIYFETDYGKAAEV----------LSYVRHAIELVLEEADKRT-GVSVSITSQIPVGAG 115
           D+     D G   +V          + YV  A+E     AD  T G  V+I S+IP+GAG
Sbjct: 65  DR-----DAGGTPDVDVPAPIVDAAMGYVDAAVEQARAAADAPTAGFDVTIDSEIPLGAG 119

Query: 116 LGSSAAVAVATIGAVSKLLDLELSKEEIAKMGHKVELLVQ-GASSGIDPTVSAIGGFLYY 174
           LGSSAAV VA I A ++ L +EL   E+A   ++VE  VQ G +S  D   SA+GG +  
Sbjct: 120 LGSSAAVVVAGIDAATRELGVELDAREVADRAYQVEHTVQDGEASRADTFCSAMGGVVRV 179

Query: 175 KQGEFEHLPFVELPIVVGYTGSSGSTKELVAMVRRRYEEMPELIEPILESMGKLVDKAKE 234
              +   L    LP V+GY G+S  T ELVA VR   EE   + + +  ++G LV + + 
Sbjct: 180 SGDDCTTLDAPALPFVIGYDGTSHDTGELVAGVRALREEFGFVADTVT-AIGDLVRRGEA 238

Query: 235 VIISKLDEEEKFLKLGELMNINHGLLDALGVSTKKLSELVYAARTAGAIGAKLTGAGGGG 294
            +      +     LG LM+INHGLL  LGVS + L  +V+AAR  GA GAKLTGAGGGG
Sbjct: 239 ALA-----DGDVATLGRLMDINHGLLSGLGVSGRTLDAMVWAARDGGADGAKLTGAGGGG 293

Query: 295 CMYALAPGKQREVATAIKIAGGTPMITRISKEGLRIE 331
            + AL  G   E A ++           +++EG+R+E
Sbjct: 294 SIVALDAGSGAETALSLTPDCEAAFRADLAREGVRVE 330


>sp|Q50559|KIME_METTH MEVALONATE KINASE (MK) >gi|1184118|gb|AAA87051.1| (U47134)
           mevalonate kinase [Methanobacterium thermoautotrophicum]
           Length = 303
           
 Score =  189 bits (476), Expect = 3e-47
 Identities = 116/306 (37%), Positives = 173/306 (55%), Gaps = 25/306 (8%)

Query: 7   ASAPAKIILFGEHSVVYGKPAIASAIDLRTYVRAEFNDSGNIKIEAHDIKTPGLIVSFSE 66
           ASAPAK ILFGEH+VVY KPAIA+AID R  V    + S ++ I       P L +  S 
Sbjct: 5   ASAPAKAILFGEHAVVYSKPAIAAAIDRRVTVTVSESSSTHVTI-------PSLGIRHSS 57

Query: 67  DKIYFETDYGKAAEVLSYVRHAIELVLEEADKRTGVSVSITSQIPVGAGLGSSAAVAVAT 126
           ++         +  +L Y+   +EL  + +     + + +  +IP G+GLGSSAA+ VA 
Sbjct: 58  ER--------PSGGILDYIGRCLELYHDASP----LDIRVEMEIPAGSGLGSSAALTVAL 105

Query: 127 IGAVSKLLDLELSKEEIAKMGHKVELLVQGASSGIDPTVSAIGGFLYYKQGEFEHLPFVE 186
           IGA+ +    +    E A   H+VE+ VQGA+S +D  +S  GG +Y            +
Sbjct: 106 IGALDRYHGRDHGPGETAARAHRVEVDVQGAASPLDTAISTYGGLVYLDSQRRVRQFEAD 165

Query: 187 L-PIVVGYTGSSGSTKELVAMVRRRYEEMPELIEPILESMGKLVDKAKEVIISKLDEEEK 245
           L  +V+ +   SG T  +VA V  R+   P+++  I++++  + + A   ++    E   
Sbjct: 166 LGDLVIAHLDYSGETARMVAGVAERFRRFPDIMGRIMDTVESITNTAYRELLRNNTEP-- 223

Query: 246 FLKLGELMNINHGLLDALGVSTKKLSELVYAARTAGAIGAKLTGAGGGGCMYALAPGKQR 305
              LGELMN+N GLLD++GVST++LS +VY AR AGA G+K+TGAGGGG + A  PG   
Sbjct: 224 ---LGELMNLNQGLLDSMGVSTRELSMMVYEARNAGAAGSKITGAGGGGSIIAHCPGCVD 280

Query: 306 EVATAI 311
           +V TA+
Sbjct: 281 DVVTAL 286


>pir||B69160 mevalonate kinase - Methanobacterium thermoautotrophicum  (strain
           Delta H) >gi|2621081|gb|AAB84553.1| (AE000796)
           mevalonate kinase [Methanobacterium thermoautotrophicum]
           Length = 303
           
 Score =  187 bits (471), Expect = 1e-46
 Identities = 115/306 (37%), Positives = 172/306 (55%), Gaps = 25/306 (8%)

Query: 7   ASAPAKIILFGEHSVVYGKPAIASAIDLRTYVRAEFNDSGNIKIEAHDIKTPGLIVSFSE 66
           ASAPAK ILFGEH+VVY KPAIA+AID R  V    + S ++ I       P L +  S 
Sbjct: 5   ASAPAKAILFGEHAVVYSKPAIAAAIDRRVTVTVSESSSTHVTI-------PSLGIRHSS 57

Query: 67  DKIYFETDYGKAAEVLSYVRHAIELVLEEADKRTGVSVSITSQIPVGAGLGSSAAVAVAT 126
           ++         +  +L Y+   +EL  + +     + + +  +IP G+GLGSSAA+ VA 
Sbjct: 58  ER--------PSGGILDYIGRCLELYHDASP----LDIRVEMEIPAGSGLGSSAALTVAL 105

Query: 127 IGAVSKLLDLELSKEEIAKMGHKVELLVQGASSGIDPTVSAIGGFLYYKQGEFEHLPFVE 186
           IG + +    +    E A   H+VE+ VQGA+S +D  +S  GG +Y            +
Sbjct: 106 IGPLDRYHGRDHGPGETAARAHRVEVDVQGAASPLDTAISTYGGLVYLDSQRRVRQFEAD 165

Query: 187 L-PIVVGYTGSSGSTKELVAMVRRRYEEMPELIEPILESMGKLVDKAKEVIISKLDEEEK 245
           L  +V+ +   SG T  +VA V  R+   P+++  I++++  + + A   ++    E   
Sbjct: 166 LGDLVIAHLDYSGETARMVAGVAERFRRFPDIMGRIMDTVESITNTAYRELLRNNTEP-- 223

Query: 246 FLKLGELMNINHGLLDALGVSTKKLSELVYAARTAGAIGAKLTGAGGGGCMYALAPGKQR 305
              LGELMN+N GLLD++GVST++LS +VY AR AGA G+K+TGAGGGG + A  PG   
Sbjct: 224 ---LGELMNLNQGLLDSMGVSTRELSMMVYEARNAGAAGSKITGAGGGGSIIAHCPGCVD 280

Query: 306 EVATAI 311
           +V TA+
Sbjct: 281 DVVTAL 286


>gb|AAK40711.1| Mevalonate kinase [Sulfolobus solfataricus]
           Length = 314
           
 Score =  171 bits (430), Expect = 7e-42
 Identities = 115/327 (35%), Positives = 180/327 (54%), Gaps = 21/327 (6%)

Query: 4   LVLASAPAKIILFGEHSVVYGKPAIASAIDLRTYVRAEFNDSGNIKIEAHDIKTPGLIVS 63
           +V A  P K+ LFGEH+VVY +PAIA  I     V+   ND   I   + +IK  G+ + 
Sbjct: 2   MVEAKVPLKLTLFGEHAVVYDRPAIAMTISESLKVKVSENDKFLIISPSLNIK--GVKLD 59

Query: 64  FSEDKIYFETDYGKAAEVLSYVRHAIELVLEEADKRTGVSVSITSQIPVGAGLGSSAAVA 123
            +E KI  E+D  +A +VL YV      VL   + +  V + I S +    GLG+SAAV 
Sbjct: 60  LNEMKI--ESD--EAKKVLRYVFE----VLNYFEMKKPVKIEINSTVEPSVGLGTSAAVI 111

Query: 124 VATIGAVSKLLDLELSKEEIAKMGHKVELLVQGASSGIDPTVSAIGGFLYYKQG--EFEH 181
           V T+ A SK L ++LS++EIAK+ H +EL VQG +S +D      GG +Y+  G   FE 
Sbjct: 112 VGTVAAYSKYLGIDLSRDEIAKISHNIELKVQGIASRMDTYTETYGGLIYFPAGGKGFEK 171

Query: 182 LPFVELPIVVGYTGSSGSTKELVAMVRRRYEEMPELIEPILESMGKLVDKAKEVIISKLD 241
           +      +  GY   S ST +++  VR   E   E+ E IL+ +G++ ++AK +I+    
Sbjct: 172 ID-TNFELTAGYIRRSMSTADVLWRVRTLKESNKEVFENILDVIGEITNRAKSLIV---- 226

Query: 242 EEEKFLKLGELMNINHGLLDALGVSTKKLSELVYAARTAGAIGAKLTGAGGGGCMYALAP 301
            E+ F +LG LM +NHGLL +LG+++ +  E+V  A+  G  G K++G G GG +  +  
Sbjct: 227 -EQNFEELGLLMYVNHGLLFSLGITSPEADEIVSRAKQLGIKGCKISGGGAGGSIICI-- 283

Query: 302 GKQREVATAIKIAGGTPMITRISKEGL 328
            K  E    ++      + + ++K+G+
Sbjct: 284 -KSVEAEVLLRSYNARIVNSTLTKDGV 309


>gi|11499870 mevalonate kinase (mvk) [Archaeoglobus fulgidus]
           >gi|8928130|sp|O27995|KIME_ARCFU MEVALONATE KINASE (MK)
           >gi|7483872|pir||A69536 mevalonate kinase (mvk) homolog
           - Archaeoglobus fulgidus >gi|2648230|gb|AAB88965.1|
           (AE000946) mevalonate kinase (mvk) [Archaeoglobus
           fulgidus]
           Length = 284
           
 Score =  168 bits (420), Expect = 1e-40
 Identities = 117/332 (35%), Positives = 173/332 (51%), Gaps = 52/332 (15%)

Query: 5   VLASAPAKIILFGEHSVVYGKPAIASAIDLRTYVRAEFNDSGNIKIEAHDIKTPGLIVSF 64
           ++ASAP KIILFGEH+VVYG+ A+ SAI+LR  V                          
Sbjct: 1   MIASAPGKIILFGEHAVVYGRHAVVSAINLRCRVSVR----------------------- 37

Query: 65  SEDKIYFETDYGKAAEVLSYVRH--AIELVLEEADKRT--GVSVSITSQIPVGAGLGSSA 120
             D+    +  G++   L Y RH   ++ V    + R   G  + I S+IP+G+GLGSSA
Sbjct: 38  KSDRFLIRSSLGESG--LDYQRHPYVVQAVKRFGELRNIPGAEIEIESEIPIGSGLGSSA 95

Query: 121 AVAVATIGAVSKLLDLELSKEEIAKMGHKVELLVQGASSGIDPTVSAIGGFLYYKQGEFE 180
           AV VATI A++   D ++ KE I +M  +VE+ VQG +SGIDP +S  GG   + +    
Sbjct: 96  AVIVATIAALNAEFDGDMDKEAIFQMAKQVEIDVQGRASGIDPFISTFGGSWLFPERRKV 155

Query: 181 HLPFVELPIVVGYTGSSGSTKELVAMVRRRYEEMPELIEPILESMGKLVDKAKEVIISKL 240
            +PF    I  G    S ST E+VA V    E  PE+++ I +++  +  +A +V  ++ 
Sbjct: 156 EMPFKFFVINFG----SRSTAEMVAKVAELRERHPEVVDKIFDAIDAISLEASDVGSAE- 210

Query: 241 DEEEKFLKLGELMNINHGLLDALGVSTKKLSELVYAARTAGAIGAKLTGAGGGGCMYALA 300
                  +L EL+ IN  LL A+GVS  ++   +      G + AK+TGAGGGGC++ L 
Sbjct: 211 -------RLEELIAINQSLLRAIGVSNPEIDRTIAELERMG-LNAKITGAGGGGCIFGLF 262

Query: 301 PGKQREVATAIKIAGGTPMITRISKEGLRIEE 332
            G++ + +           I    KEG+RIEE
Sbjct: 263 KGEKPKGS----------FIVEPEKEGVRIEE 284


>sp|Q58487|KIME_METJA MEVALONATE KINASE (MK) >gi|2129120|pir||F64435 mevalonate kinase
           (EC 2.7.1.36) - Methanococcus jannaschii
           >gi|1591731|gb|AAB99088.1| (U67551) mevalonate kinase
           [Methanococcus jannaschii]
           Length = 312
           
 Score =  146 bits (365), Expect = 3e-34
 Identities = 103/334 (30%), Positives = 172/334 (50%), Gaps = 29/334 (8%)

Query: 5   VLASAPAKIILFGEHSVVYGKPAIASAIDLRTYVRAEFNDSGNIKIEAHDIKTPGLIVSF 64
           ++   P+K+ILFGEH+VVYG  AI+ AIDL + +  +      I +  +D+    L ++ 
Sbjct: 1   MIIETPSKVILFGEHAVVYGYRAISMAIDLTSTIEIKETQEDEIILNLNDLNK-SLGLNL 59

Query: 65  SEDKIYFETDYGKAAEVLSYVRHAIELVLEEADKRTGVSVSITSQIPVGAGLGSSAAVAV 124
           +E K     ++G     L  +++ ++ +    + +TG  ++I+S+IP+  GLGSSA++ +
Sbjct: 60  NEIKNINPNNFGDFKYCLCAIKNTLDYL--NIEPKTGFKINISSKIPISCGLGSSASITI 117

Query: 125 ATIGAVSKLLDLELSKEEIAKMGHKVELLVQGASSGIDPTVSAIGGFLYYKQGEFEHLPF 184
            TI AVS   + EL  +EIAK+G+ VE  +QG +S  D +     G L  K  +F     
Sbjct: 118 GTIKAVSGFYNKELKDDEIAKLGYMVEKEIQGKASITDTSTITYKGILEIKNNKFR---- 173

Query: 185 VELPIVVGYTGSSGSTKELVAMVRRRYEEMPELIEPI--LESMGKLVDKAKEVI--ISKL 240
               I   +     + K L+    +R ++  EL+  +  +E+  ++  +  +VI    K+
Sbjct: 174 ---KIKGEFEEFLKNCKFLIVYAEKRKKKTAELVNEVAKIENKDEIFKEIDKVIDEALKI 230

Query: 241 DEEEKFLKLGELMNINHGLLDALGVSTKKLSELVYAARTAGAIGAKLTGAGGGGCMYALA 300
             +E F   G+LM  NH LL  L +ST KL  +V      G  GAKLTGAGGGGC+  L 
Sbjct: 231 KNKEDF---GKLMTKNHELLKKLNISTPKLDRIVDIGNRFG-FGAKLTGAGGGGCVIILV 286

Query: 301 PGKQREVATAIKIAGGTPMITRISKEGLRIEEVR 334
             ++ +            ++  ++KE +RI   R
Sbjct: 287 NEEKEK-----------ELLKELNKEDVRIFNCR 309


>gi|4557769 mevalonate kinase [Homo sapiens] >gi|417215|sp|Q03426|KIME_HUMAN
           MEVALONATE KINASE (MK) >gi|284302|pir||A42919 mevalonate
           kinase (EC 2.7.1.36) - human >gi|187561|gb|AAB59362.1|
           (M88468) mevalonate kinase [Homo sapiens]
           >gi|450347|emb|CAA53060.1| (X75311) ORF for mevalonate
           kinase [Homo sapiens] >gi|9049533|gb|AAF82407.1|
           (AF217535) mevalonate kinase [Homo sapiens]
           Length = 396
           
 Score =  133 bits (331), Expect = 3e-30
 Identities = 110/368 (29%), Positives = 177/368 (47%), Gaps = 64/368 (17%)

Query: 1   MPRLVLASAPAKIILFGEHSVVYGKPAIASAIDLRTYVRAEFNDSGNIKIEAHDIKTPGL 60
           +  ++L SAP K+IL GEH+VV+GK A+A +++LRT++R + + +G +     D+  P +
Sbjct: 2   LSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKV-----DLSLPNI 56

Query: 61  IVSFSEDKIYFE---TDYGKAAEVLSYVRHAIELVLEEADKRTGVSVS------------ 105
            +  + D    +   T + +  +V +     +E + E A      +V+            
Sbjct: 57  GIKRAWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLY 116

Query: 106 ----------------ITSQIPVGAGLGSSAAVAVATIGAVSKLL--------------- 134
                           + S++P GAGLGSSAA +V    A+  +                
Sbjct: 117 LSICRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNR 176

Query: 135 ----DLELSKEEIAKMGHKVELLVQGASSGIDPTVSAIGGFLYYKQGEFEHLP-FVELPI 189
               DLEL    I K   + E ++ G  SG+D  VS  GG L Y QG+   L     L I
Sbjct: 177 WTKEDLEL----INKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQI 232

Query: 190 VVGYTGSSGSTKELVAMVRRRYEEMPELIEPILESMGKLVDKAKEVI--ISKLDEEEKFL 247
           ++  T    +T+ LVA VR R  + PE++ P+L S+  +  + + V+  + +    E++L
Sbjct: 233 LLTNTKVPRNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYL 292

Query: 248 KLGELMNINHGLLDALGVSTKKLSELVYAARTAGAIGAKLTGAGGGGC-MYALAPGKQRE 306
            L EL+++N   L+ALGV    L +L    R  G + +KLTGAGGGGC +  L PG ++ 
Sbjct: 293 VLEELIDMNQHHLNALGVGHASLDQLCQVTRARG-LHSKLTGAGGGGCGITLLKPGLEQP 351

Query: 307 VATAIKIA 314
              A K A
Sbjct: 352 EVEATKQA 359


>emb|CAA53059.1| (X75311) ORF for viral-cellular fusion transcript [Homo sapiens]
           Length = 557
           
 Score =  133 bits (331), Expect = 3e-30
 Identities = 110/368 (29%), Positives = 177/368 (47%), Gaps = 64/368 (17%)

Query: 1   MPRLVLASAPAKIILFGEHSVVYGKPAIASAIDLRTYVRAEFNDSGNIKIEAHDIKTPGL 60
           +  ++L SAP K+IL GEH+VV+GK A+A +++LRT++R + + +G +     D+  P +
Sbjct: 163 LSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKV-----DLSLPNI 217

Query: 61  IVSFSEDKIYFE---TDYGKAAEVLSYVRHAIELVLEEADKRTGVSVS------------ 105
            +  + D    +   T + +  +V +     +E + E A      +V+            
Sbjct: 218 GIKRAWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLY 277

Query: 106 ----------------ITSQIPVGAGLGSSAAVAVATIGAVSKLL--------------- 134
                           + S++P GAGLGSSAA +V    A+  +                
Sbjct: 278 LSICRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNR 337

Query: 135 ----DLELSKEEIAKMGHKVELLVQGASSGIDPTVSAIGGFLYYKQGEFEHLP-FVELPI 189
               DLEL    I K   + E ++ G  SG+D  VS  GG L Y QG+   L     L I
Sbjct: 338 WTKEDLEL----INKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQI 393

Query: 190 VVGYTGSSGSTKELVAMVRRRYEEMPELIEPILESMGKLVDKAKEVI--ISKLDEEEKFL 247
           ++  T    +T+ LVA VR R  + PE++ P+L S+  +  + + V+  + +    E++L
Sbjct: 394 LLTNTKVPRNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYL 453

Query: 248 KLGELMNINHGLLDALGVSTKKLSELVYAARTAGAIGAKLTGAGGGGC-MYALAPGKQRE 306
            L EL+++N   L+ALGV    L +L    R  G + +KLTGAGGGGC +  L PG ++ 
Sbjct: 454 VLEELIDMNQHHLNALGVGHASLDQLCQVTRARG-LHSKLTGAGGGGCGITLLKPGLEQP 512

Query: 307 VATAIKIA 314
              A K A
Sbjct: 513 EVEATKQA 520


>gi|11436567 mevalonate kinase [Homo sapiens]
           Length = 421
           
 Score =  133 bits (331), Expect = 3e-30
 Identities = 110/368 (29%), Positives = 177/368 (47%), Gaps = 64/368 (17%)

Query: 1   MPRLVLASAPAKIILFGEHSVVYGKPAIASAIDLRTYVRAEFNDSGNIKIEAHDIKTPGL 60
           +  ++L SAP K+IL GEH+VV+GK A+A +++LRT++R + + +G +     D+  P +
Sbjct: 27  LSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKV-----DLSLPNI 81

Query: 61  IVSFSEDKIYFE---TDYGKAAEVLSYVRHAIELVLEEADKRTGVSVS------------ 105
            +  + D    +   T + +  +V +     +E + E A      +V+            
Sbjct: 82  GIKRAWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLY 141

Query: 106 ----------------ITSQIPVGAGLGSSAAVAVATIGAVSKLL--------------- 134
                           + S++P GAGLGSSAA +V    A+  +                
Sbjct: 142 LSICRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNR 201

Query: 135 ----DLELSKEEIAKMGHKVELLVQGASSGIDPTVSAIGGFLYYKQGEFEHLP-FVELPI 189
               DLEL    I K   + E ++ G  SG+D  VS  GG L Y QG+   L     L I
Sbjct: 202 WTKEDLEL----INKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQI 257

Query: 190 VVGYTGSSGSTKELVAMVRRRYEEMPELIEPILESMGKLVDKAKEVI--ISKLDEEEKFL 247
           ++  T    +T+ LVA VR R  + PE++ P+L S+  +  + + V+  + +    E++L
Sbjct: 258 LLTNTKVPRNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYL 317

Query: 248 KLGELMNINHGLLDALGVSTKKLSELVYAARTAGAIGAKLTGAGGGGC-MYALAPGKQRE 306
            L EL+++N   L+ALGV    L +L    R  G + +KLTGAGGGGC +  L PG ++ 
Sbjct: 318 VLEELIDMNQHHLNALGVGHASLDQLCQVTRARG-LHSKLTGAGGGGCGITLLKPGLEQP 376

Query: 307 VATAIKIA 314
              A K A
Sbjct: 377 EVEATKQA 384


>gb|AAG02445.1|AF290095_1 (AF290095) mevalonate kinase [Enterococcus faecium]
           Length = 314
           
 Score =  132 bits (329), Expect = 5e-30
 Identities = 100/308 (32%), Positives = 154/308 (49%), Gaps = 24/308 (7%)

Query: 12  KIILFGEHSVVYGKPAIASAIDLRTYVRAEFNDSGNIKIEAHDIKTPGLIVSFSEDKIYF 71
           KIIL GEH+VVYG+PAIA      T V A         +E  D     L+ S      Y+
Sbjct: 12  KIILMGEHAVVYGEPAIAFPF-YATKVTAF--------LEELDAMDDQLVSS------YY 56

Query: 72  ETDYGKAAEVLSYVRHAIELVLEEADKRTGVSVSITSQIPVGAGLGSSAAVAVATIGAVS 131
             +  +A   L  ++     + ++ D +  + ++I S IP   G+GSSAAVA A   A  
Sbjct: 57  SGNLAEAPHALKNIKKLFIHLKKQHDIQKNLQLTIESTIPAERGMGSSAAVATAVTRAFY 116

Query: 132 KLLDLELSKEEIAKMGHKVELLVQGASSGIDPTVSAIGGFLYYKQGE-FEHLPF-VELPI 189
             L   LS+E + +     E +  G  SGID   ++    +Y+ +G  F++    ++  +
Sbjct: 117 DYLAFPLSREILLENVQLSEKIAHGNPSGIDAAATSSLQPIYFTKGHPFDYFSLNIDAFL 176

Query: 190 VVGYTGSSGSTKELVAMVRRRYEEMPELIEPILESMGKLVDKAKEVIISKLDEEEKFLKL 249
           +V  TG  G T+E V  V   +E  P     +++ +G L  +AK+ II    E      L
Sbjct: 177 IVADTGIKGQTREAVKDVAHLFETQPHETGQMIQKLGYLTKQAKQAIIENSPET-----L 231

Query: 250 GELMNINHGLLDALGVSTKKLSELVYAARTAGAIGAKLTGAGGGGCMYALAPGKQR--EV 307
            + M+ +  LL+ L +S   L+ L+  A+  GA+GAKLTG G GGCM ALA  K +  E+
Sbjct: 232 AQTMDESQSLLEKLTISNDFLNLLIQTAKDTGALGAKLTGGGRGGCMIALAQTKTKAQEI 291

Query: 308 ATAIKIAG 315
           + A++ AG
Sbjct: 292 SQALEDAG 299


>sp|P17256|KIME_RAT MEVALONATE KINASE (MK) >gi|111959|pir||A35629 mevalonate kinase (EC
           2.7.1.36) [validated] - rat >gi|205378|gb|AAA41588.1|
           (M29472) mevalonate kinase (EC 2.7.1.36) [Rattus
           norvegicus]
           Length = 395
           
 Score =  131 bits (326), Expect = 1e-29
 Identities = 113/359 (31%), Positives = 173/359 (47%), Gaps = 46/359 (12%)

Query: 1   MPRLVLASAPAKIILFGEHSVVYGKPAIASAIDLRTYVRAEFNDSGNIKI---------- 50
           +  ++L SAP K+IL GEH+VV+GK A+A A++LRT++      +G + +          
Sbjct: 2   LSEVLLVSAPGKVILHGEHAVVHGKVALAVALNLRTFLVLRPQSNGKVSLNLPNVGIKQV 61

Query: 51  --------------EAHDIKTPGLIVSFSEDKIYFETDYGKAAEVLSYVRHAIELVLEEA 96
                         E  D+  P L       K+          E LS +      +    
Sbjct: 62  WDVATLQLLDTGFLEQGDVPAPTLEQLEKLKKVAGLPRDCVGNEGLSLLAFLYLYLAICR 121

Query: 97  DKRT--GVSVSITSQIPVGAGLGSSAAVAVATIGAV--------SKLLDL-------ELS 139
            +RT   + + + S++P GAGLGSSAA +V    A+        + L D        E  
Sbjct: 122 KQRTLPSLDIMVWSELPPGAGLGSSAAYSVCVAAALLTACEEVTNPLKDRGSIGSWPEED 181

Query: 140 KEEIAKMGHKVELLVQGASSGIDPTVSAIGGFLYYKQGEFEHLPFVE-LPIVVGYTGSSG 198
            + I K  ++ E ++ G  SG+D +VS  GG L Y+QG+   L  +  L I++  T    
Sbjct: 182 LKSINKWAYEGERVIHGNPSGVDNSVSTWGGALRYQQGKMSSLKRLPALQILLTNTKVPR 241

Query: 199 STKELVAMVRRRYEEMPELIEPILESMGKLVDKAKEVI--ISKLDEEEKFLKLGELMNIN 256
           STK LVA VR R  + PE++ P+L S+  +  + + V+  ++     E++L L ELM++N
Sbjct: 242 STKALVAGVRSRLIKFPEIMAPLLTSIDAISLECERVLGEMAAAPVPEQYLVLEELMDMN 301

Query: 257 HGLLDALGVSTKKLSELVYAARTAGAIGAKLTGAGGGGC-MYALAPGKQREVATAIKIA 314
              L+ALGV    L +L       G + +KLTGAGGGGC +  L PG +R    A K A
Sbjct: 302 QHHLNALGVGHASLDQLCQVTAAHG-LHSKLTGAGGGGCGITLLKPGLERAKVEAAKQA 359


>sp|Q9Y946|KIME_AERPE MEVALONATE KINASE (MK) >gi|7521212|pir||F72474 probable mevalonate
           kinase APE2439 - Aeropyrum pernix  (strain K1)
           >gi|5106143|dbj|BAA81454.1| (AP000064) 324aa long
           hypothetical mevalonate kinase [Aeropyrum pernix]
           Length = 324
           
 Score =  131 bits (325), Expect = 2e-29
 Identities = 110/343 (32%), Positives = 163/343 (47%), Gaps = 31/343 (9%)

Query: 1   MPRLVLASAPAKIILFGEHSVVYGKPAIASAIDLRTYVRAEFNDSGNI----KIEAHDIK 56
           M R   ASAP K+I+ GEH VV G  AI +AI  R  V       G +     +  H   
Sbjct: 1   MRRAARASAPGKVIIVGEHFVVRGSLAIVAAIGRRLRVTVRSGGKGIVLESSMLGRHSAP 60

Query: 57  TPGLIVSFSEDKIYFETDYGKAAEVLSYVRHAIELVLEEADKRTGV---SVSITSQIPVG 113
            PG                G AA+V   +   I ++   A +   V   ++ + S IP  
Sbjct: 61  LPG---------------QGAAAKVSPVLEPYIAVLRSLAARGYSVVPHTILVESGIPPR 105

Query: 114 AGLGSSAAVAVATIGAVSKLLDLELSKEEIAKMGHKVELLVQGASSGIDPTVSAIGGFLY 173
           AGLGSSAA  VA   + S +    LS E++  +  + E +  G  SG+D T++  GG L 
Sbjct: 106 AGLGSSAASMVAYALSYSAMHGDPLSAEDLYSVAMEGEKIAHGKPSGVDVTIAVRGGVLA 165

Query: 174 YKQGE--FEHLP-FVELPIVVGYTGSSGSTKELVAMVRRRYEEMPELIEPILESMGKLVD 230
           Y++GE   +  P    + ++V  TG    T+++V  V    + + E    I  +   +  
Sbjct: 166 YRRGENPVDIRPGLTGVTLLVADTGVERRTRDVVEHVLSIADALGEASTYIYRAADLIAR 225

Query: 231 KAKEVIISKLDEEEKFLKLGELMNINHGLLDALGVSTKKLSELVYAARTAGAIGAKLTGA 290
           +A   I  K D E    +LG +MN   GLL +LG S+ ++  LVY  R+AGA+GAKLTGA
Sbjct: 226 EALHAI-EKGDAE----RLGLIMNAAQGLLSSLGASSLEIETLVYRMRSAGALGAKLTGA 280

Query: 291 GGGGCMYAL-APGKQREVATAIKIAGGTPMITRISKEGLRIEE 332
           G GGC+  L   G+      ++  +        I++EG R+EE
Sbjct: 281 GWGGCVIGLFKEGEVERGLESVVESSSQAFTASIAEEGARLEE 323


>sp|Q9R008|KIME_MOUSE MEVALONATE KINASE (MK) >gi|6006984|gb|AAF00700.1|AF137598_1
           (AF137598) mevalonate kinase [Mus musculus]
           Length = 395
           
 Score =  127 bits (315), Expect = 2e-28
 Identities = 107/355 (30%), Positives = 166/355 (46%), Gaps = 46/355 (12%)

Query: 5   VLASAPAKIILFGEHSVVYGKPAIASAIDLRTYVRAEFNDSGNIKIEAHDI--------- 55
           +L SAP K+IL GEH+VV+GK A+A+A++LRT++      +G + +   +I         
Sbjct: 6   LLVSAPGKVILHGEHAVVHGKVALAAALNLRTFLLLRPQSNGKVSVNLPNIGIKQVWDVG 65

Query: 56  KTPGLIVSFSE------------DKIYFETDY-----GKAAEVLSYVRHAIELVLEEADK 98
               L  SF E            +K+    D      G     L    +    +  +   
Sbjct: 66  MLQRLDTSFLEQGDVSVPTLEQLEKLKKMGDLPRDRAGNEGMALLAFLYLYLAICRKQRT 125

Query: 99  RTGVSVSITSQIPVGAGLGSSAAVAVATIGAVSKLLDL---------------ELSKEEI 143
              + + + S++P GAGLGSSAA +V    A+    +                E   + I
Sbjct: 126 LPSLDMVVWSELPPGAGLGSSAAYSVCLAAALLTACEEVSNPLKDGVSVSRWPEEDLKSI 185

Query: 144 AKMGHKVELLVQGASSGIDPTVSAIGGFLYYKQGEFEHLPFV-ELPIVVGYTGSSGSTKE 202
            K   + E ++ G  SG+D  VS  GG L ++QG    L  +  L I++  T    STK 
Sbjct: 186 NKWAFEGERVIHGNPSGVDNAVSTWGGALRFQQGTMSSLKSLPSLQILLTNTKVPRSTKA 245

Query: 203 LVAMVRRRYEEMPELIEPILESMGKLVDKAKEVI--ISKLDEEEKFLKLGELMNINHGLL 260
           LVA VR R  + PE++ P+L S+  +  + + V+  +      E++L L EL+++N   L
Sbjct: 246 LVAAVRSRLTKFPEIVAPLLTSIDAISLECERVLGEMVAAPVPEQYLVLEELIDMNQHHL 305

Query: 261 DALGVSTKKLSELVYAARTAGAIGAKLTGAGGGGC-MYALAPGKQREVATAIKIA 314
           +ALGV    L +L       G + +KLTGAGGGGC +  L PG ++    A K A
Sbjct: 306 NALGVGHNSLDQLCQVTAAHG-LHSKLTGAGGGGCGITLLKPGLEQATVEAAKQA 359


>gb|AAG02424.1|AF290087_1 (AF290087) mevalonate kinase [Staphylococcus aureus]
           Length = 306
           
 Score =  126 bits (313), Expect = 4e-28
 Identities = 107/319 (33%), Positives = 160/319 (49%), Gaps = 28/319 (8%)

Query: 1   MPRLVLASAPAKIILFGEHSVVYGKPAIASAIDLRTYVRAEFNDSGNIKIEAHDIKTPGL 60
           M R     +  KIIL GEH+V +G+PAIA            FN +G IK+    +++ G 
Sbjct: 1   MTRKGYGESTGKIILIGEHAVTFGEPAIA----------VPFN-AGKIKVLIEALES-GN 48

Query: 61  IVSFSEDKIYFETDYGKAAEVLSYVRHAIELVLEEADKRTGVSVSITSQIPVGAGLGSSA 120
             S   D +Y    Y     + S V   +EL     +    ++V+I + +P   GLGSSA
Sbjct: 49  YSSIKSD-VYDGMLYDAPDHLKSLVNRFVEL----NNITEPLAVTIQTNLPPSRGLGSSA 103

Query: 121 AVAVATIGAVSKLLDLELSKEEIAKMGHKVELLVQGASSGIDPTVSAIGGFLYYKQGEFE 180
           AVAVA + A    L   L+KEE+ +  +  E +  G  SGID      G  +++++G+ E
Sbjct: 104 AVAVAFVRASYDFLGKSLTKEELIEKANWAEQIAHGKPSGIDTQTIVSGKPVWFQKGQAE 163

Query: 181 HLPFVELP--IVVGYTGSSGSTKELVAMVRRRYEEMPELIEPILESMGKLVDKAKEVIIS 238
            L  + L   +VV  TG  GST++ V  V +  E+ P+ +  + + +GKLV +A +VI  
Sbjct: 164 TLKTLSLDGYMVVIDTGVKGSTRQAVEDVHKLCED-PQYMSHV-KHIGKLVLRASDVI-- 219

Query: 239 KLDEEEKFLKLGELMNINHGLLDALGVSTKKLSELVYAARTAGAIGAKLTGAGGGGCMYA 298
              E   F  L ++ N  H  L AL VS  K+ +L+   +  GAI  KLTGAG GG M  
Sbjct: 220 ---EHHNFEALADIFNECHADLKALTVSHDKIEQLMKIGKENGAIAGKLTGAGRGGSMLL 276

Query: 299 LAPG--KQREVATAIKIAG 315
           LA      + +  A++ AG
Sbjct: 277 LAKDLPTAKNIVKAVEKAG 295


>gb|AAG02440.1|AF290093_1 (AF290093) mevalonate kinase [Enterococcus faecalis]
           Length = 314
           
 Score =  126 bits (313), Expect = 4e-28
 Identities = 94/302 (31%), Positives = 147/302 (48%), Gaps = 24/302 (7%)

Query: 6   LASAPAKIILFGEHSVVYGKPAIASAIDLRTYVRAEFNDSGNIKIEAHDIKTPGLIVSFS 65
           L  A  KIIL GEH+VVYG+PAIA      T + A F  +  ++I+       GL+    
Sbjct: 8   LGQATGKIILMGEHAVVYGEPAIAFPFQA-TEITAVFTPAKTMQIDCAYFT--GLLEDVP 64

Query: 66  EDKIYFETDYGKAAEVLSYVRHAIELVLEEADKRTGVSVSITSQIPVGAGLGSSAAVAVA 125
           ++           A +   V+  +  + E+  K T   +++TS IP   G+GSSAA AVA
Sbjct: 65  QE----------LANIKEVVQQTLHFLKEDTFKGT---LTLTSTIPAERGMGSSAATAVA 111

Query: 126 TIGAVSKLLDLELSKEEIAKMGHKVELLVQGASSGIDPTVSAIGGFLYYKQG---EFEHL 182
            + ++    D   + +E+ ++    E +  G  SGID   ++    L++ +G       +
Sbjct: 112 IVRSLFDYFDYAYTYQELFELVSLSEKIAHGNPSGIDAAATSGADPLFFTRGFPPTHFSM 171

Query: 183 PFVELPIVVGYTGSSGSTKELVAMVRRRYEEMPELIEPILESMGKLVDKAKEVIISKLDE 242
                 +VV  TG  G T+E V  + +  +  P  I   ++ +G    +AK+ I+   D+
Sbjct: 172 NLSNAYLVVADTGIKGQTREAVKDIAQLAQNNPTAIAETMKQLGSFTKEAKQAILQ--DD 229

Query: 243 EEKFLKLGELMNINHGLLDALGVSTKKLSELVYAARTAGAIGAKLTGAGGGGCMYALAPG 302
           ++K   LG+LM +    L  L VS   L  LV  +   GA+GAKLTG G GGCM AL   
Sbjct: 230 KQK---LGQLMTLAQEQLQQLTVSNDMLDRLVALSLEHGALGAKLTGGGRGGCMIALTDN 286

Query: 303 KQ 304
           K+
Sbjct: 287 KK 288


>sp|Q09780|KIME_SCHPO PUTATIVE MEVALONATE KINASE (MK) >gi|2117774|pir||S62440 mevalonate
           kinase (EC 2.7.1.36) - fission yeast
           (Schizosaccharomyces pombe) >gi|1008996|emb|CAA91104.1|
           (Z54308) putative mevalonate kinase [Schizosaccharomyces
           pombe] >gi|2967444|dbj|BAA25169.1| (AB000541) putative
           mevalonate kinase [Schizosaccharomyces pombe]
           Length = 404
           
 Score =  126 bits (313), Expect = 4e-28
 Identities = 98/346 (28%), Positives = 162/346 (46%), Gaps = 42/346 (12%)

Query: 1   MPRLVLASAPAKIILFGEHSVVYGKPAIASAIDLRTYVRAEFNDSGNIKIEAHDIKTPGL 60
           M + ++ S+P K ILFGEH+VVYG  A+A+A+ LR+Y + +  ++  I I   DI T   
Sbjct: 1   MSKSLIVSSPGKTILFGEHAVVYGATALAAAVSLRSYCKLQTTNNNEIVIVMSDIGTERR 60

Query: 61  --IVSFSEDKIYFET-DYGKAAEVLSYVRHAIELVLEE-------------------ADK 98
             + S     +  E   +  ++  L  ++   EL+  E                   +  
Sbjct: 61  WNLQSLPWQHVTVENVQHPASSPNLDLLQGLGELLKNEENGLIHSAMLCTLYLFTSLSSP 120

Query: 99  RTGVSVSITSQIPVGAGLGSSAAVAVATIGAV-----------SKLLDLELSKEEIAKMG 147
             G +++I+SQ+P+GAGLGSSA ++V    ++           S  L    +   I    
Sbjct: 121 SQGCTLTISSQVPLGAGLGSSATISVVVATSLLLAFGNIEPPSSNSLQNNKALALIEAWS 180

Query: 148 HKVELLVQGASSGIDPTVSAIGGFLYYKQGEFEHLPFVE-------LPIVVGYTGSSGST 200
              E  + G  SGID  V+  GG + +++         E       L +++  T    ST
Sbjct: 181 FLGECCIHGTPSGIDNAVATNGGLIAFRKATAHQSAMKEFLKPKDTLSVMITDTKQPKST 240

Query: 201 KELVAMVRRRYEEMPELIEPILESMGKLVDKAKEVIISKLDEEEKFLKLGELMNINHGLL 260
           K+LV  V    E +P +I+ I++++  +   A   + S+ D+     KLGE + +N  LL
Sbjct: 241 KKLVQGVFELKERLPTVIDSIIDAIDGISKSAVLALTSESDKNSSAKKLGEFIVLNQKLL 300

Query: 261 DALGVSTKKLSELVYAARTAGAIGAKLTGAGGGGCMYALAPGKQRE 306
           + LGVS   +  ++ A ++ G    KLTGAGGGGC   L   + +E
Sbjct: 301 ECLGVSHYSIDRVLQATKSIG--WTKLTGAGGGGCTITLLTPECKE 344


>gi|6323864 mevalonate kinase; Erg12p [Saccharomyces cerevisiae]
           >gi|125407|sp|P07277|KIME_YEAST MEVALONATE KINASE (MK)
           (MVK) >gi|73086|pir||BVBYR1 mevalonate kinase (EC
           2.7.1.36) - yeast (Saccharomyces cerevisiae)
           >gi|3684|emb|CAA39359.1| (X55875) mevalonate kinase
           [Saccharomyces cerevisiae] >gi|4287|emb|CAA29487.1|
           (X06114) ORF1 (put. RAR1 protein) (AA 1-443)
           [Saccharomyces cerevisiae] >gi|854460|emb|CAA89923.1|
           (Z49809) Rar1p [Saccharomyces cerevisiae]
           Length = 443
           
 Score =  125 bits (311), Expect = 7e-28
 Identities = 118/358 (32%), Positives = 177/358 (48%), Gaps = 66/358 (18%)

Query: 6   LASAPAKIILFGEHSVVYGKPAIASAID-LRTYVR-AEFNDSGNIKIEAHDIK------- 56
           L SAP K+I+FGEHS VY KPA+A+++  LRTY+  +E +    I+++  DI        
Sbjct: 6   LTSAPGKVIIFGEHSAVYNKPAVAASVSALRTYLLISESSAPDTIELDFPDISFNHKWSI 65

Query: 57  ------TPGLIVSFSEDKIYFETDYGKAAEVLSYVRHAIELVLEE--------------- 95
                 T   + S    K    TD G + E++S +   +  + E                
Sbjct: 66  NDFNAITEDQVNSQKLAKAQQATD-GLSQELVSLLDPLLAQLSESFHYHAAFCFLYMFVC 124

Query: 96  -ADKRTGVSVSITSQIPVGAGLGSSA------AVAVATIGAVSKLLDLELSKEE----IA 144
                  +  S+ S +P+GAGLGSSA      A+A+A +G +    DLE   E     + 
Sbjct: 125 LCPHAKNIKFSLKSTLPIGAGLGSSASISVSLALAMAYLGGLIGSNDLEKLSENDKHIVN 184

Query: 145 KMGHKVELLVQGASSGIDPTVSAIGGFLYYKQ---------GEFEHL-PFVELPIVVGYT 194
           +     E  + G  SGID  V+  G  L +++           F+ L  F  +P+++ YT
Sbjct: 185 QWAFIGEKCIHGTPSGIDNAVATYGNALLFEKDSHNGTINTNNFKFLDDFPAIPMILTYT 244

Query: 195 GSSGSTKELVAMVRRRY-EEMPELIEPILESMGKLVDKAKEVI--ISK---LDEE----- 243
               STK+LVA VR    E+ PE+++PIL++MG+   +  E++  +SK    D+E     
Sbjct: 245 RIPRSTKDLVARVRVLVTEKFPEVMKPILDAMGECALQGLEIMTKLSKCKGTDDEAVETN 304

Query: 244 -EKFLKLGELMNINHGLLDALGVSTKKLSELVYAARTAGAIGA-KLTGAGGGGCMYAL 299
            E + +L EL+ INHGLL ++GVS   L EL+        IG+ KLTGAGGGGC   L
Sbjct: 305 NELYEQLLELIRINHGLLVSIGVSHPGL-ELIKNLSDDLRIGSTKLTGAGGGGCSLTL 361


>gb|AAD45421.1|L77688_1 (L77688) mevalonate kinase [Arabidopsis thaliana]
           Length = 376
           
 Score =  125 bits (310), Expect = 9e-28
 Identities = 110/343 (32%), Positives = 161/343 (46%), Gaps = 48/343 (13%)

Query: 5   VLASAPAKIILFGEHSVVYGKPAIASAIDLRTYVRAEFNDSGNIKIEAHDIKTPGLIVSF 64
           V A AP KIIL GEH+VV+G  A+A+AIDL TYV   F    N       +K   L  S+
Sbjct: 3   VKARAPGKIILAGEHAVVHGSTAVAAAIDLYTYVTLRFPLPSNNDRLTLQLKDISLEFSW 62

Query: 65  SEDKIYFETDYGKAA-----------EVLSYVRHAIE---LVLEEADKRTGVS------- 103
           S  +I     Y  +            E L  +   +E   L  E+    +G+S       
Sbjct: 63  SLARIKEAIPYDSSTLCRSTPASCSEETLKSIAVLVEEQNLPKEKMWLSSGISTFLWLYT 122

Query: 104 ---------VSITSQIPVGAGLGSSAAVAVATIGAVS-------------KLLDLELSKE 141
                    V I S++P G+GLGSSAA+ VA   A+                LD E + E
Sbjct: 123 RIIGFNPATVVINSELPYGSGLGSSAALCVALTAALLASSISEKTRGNGWSSLD-ETNLE 181

Query: 142 EIAKMGHKVELLVQGASSGIDPTVSAIGGFLYYKQGEFEHLPF-VELPIVVGYTGSSGST 200
            + K   + E ++ G  SGID TVSA G  + +  GE   L   + L +++  T    +T
Sbjct: 182 LLNKWAFEGEKIIHGKPSGIDNTVSAYGNMIKFCSGEITRLQSNMPLRMLITNTRVGRNT 241

Query: 201 KELVAMVRRRYEEMPELIEPILESMGKLVDKAKEVIISKLDEE--EKFLKLGELMNINHG 258
           K LV+ V +R    P+ ++ +  ++  +  +   +I SK +    EK  ++ ELM +N G
Sbjct: 242 KALVSGVSQRAVRHPDAMKSVFNAVDSISKELAAIIQSKDETSVTEKEERIKELMEMNQG 301

Query: 259 LLDALGVSTKKLSELVYAARTAGAIGAKLTGAGGGGCMYALAP 301
           LL ++GVS   + E V        + +KLTGAGGGGC+  L P
Sbjct: 302 LLLSMGVSHSSI-EAVILTTVKHKLVSKLTGAGGGGCVLTLLP 343


>sp|P46086|KIME_ARATH MEVALONATE KINASE (MK) >gi|541880|pir||S42088 mevalonate kinase (EC
           2.7.1.36) - Arabidopsis thaliana
           >gi|456614|emb|CAA54820.1| (X77793) mevalonate kinase
           [Arabidopsis thaliana]
           >gi|4883990|gb|AAD31719.1|AF141853_1 (AF141853)
           mevalonate kinase [Arabidopsis thaliana]
           Length = 378
           
 Score =  123 bits (306), Expect = 3e-27
 Identities = 107/345 (31%), Positives = 165/345 (47%), Gaps = 50/345 (14%)

Query: 5   VLASAPAKIILFGEHSVVYGKPAIASAIDLRTYVR-------AEFNDSGNIKIEAHDIKT 57
           V A AP KIIL GEH+VV+G  A+A+AIDL TYV        AE ND   ++++   ++ 
Sbjct: 3   VKARAPGKIILAGEHAVVHGSTAVAAAIDLYTYVTLRFPLPSAENNDRLTLQLKDISLEF 62

Query: 58  PGLI------VSFSEDKIYFETDYGKAAEVLSYVRHAIE---LVLEEADKRTGVS----- 103
              +      + +    +   T    + E L  +   +E   L  E+    +G+S     
Sbjct: 63  SWSLARIKEAIPYDSSTLCRSTPASCSEETLKSIAVLVEEQNLPKEKMWLSSGISTFLWL 122

Query: 104 -----------VSITSQIPVGAGLGSSAAVAVATIGAVS-------------KLLDLELS 139
                      V I S++P G+GLGSSAA+ VA   A+                LD E +
Sbjct: 123 YTRIIGFNPATVVINSELPYGSGLGSSAALCVALTAALLASSISEKTRGNGWSSLD-ETN 181

Query: 140 KEEIAKMGHKVELLVQGASSGIDPTVSAIGGFLYYKQGEFEHLPF-VELPIVVGYTGSSG 198
            E + K   + E ++ G  SGID TVSA G  + +  GE   L   + L +++  T    
Sbjct: 182 LELLNKWAFEGEKIIHGKPSGIDNTVSAYGNMIKFCSGEITRLQSNMPLRMLITNTRVGR 241

Query: 199 STKELVAMVRRRYEEMPELIEPILESMGKLVDKAKEVIISKLDEE--EKFLKLGELMNIN 256
           +TK LV+ V +R    P+ ++ +  ++  +  +   +I SK +    EK  ++ ELM +N
Sbjct: 242 NTKALVSGVSQRAVRHPDAMKSVFNAVDSISKELAAIIQSKDETSVTEKEERIKELMEMN 301

Query: 257 HGLLDALGVSTKKLSELVYAARTAGAIGAKLTGAGGGGCMYALAP 301
            GLL ++GVS   + E V        + +KLTGAGGGGC+  L P
Sbjct: 302 QGLLLSMGVSHSSI-EAVILTTVKHKLVSKLTGAGGGGCVLTLLP 345


>dbj|BAB07817.1| (AB037907) mevalonate kinase [Streptomyces griseolosporeus]
           Length = 334
           
 Score =  123 bits (305), Expect = 3e-27
 Identities = 103/311 (33%), Positives = 148/311 (47%), Gaps = 20/311 (6%)

Query: 9   APAKIILFGEHSVVYGKPAIASAIDLRTYVRAEFNDSGNIKIEAHDIKTPGLIVSFSEDK 68
           A AK IL GEH+VVYG PA+A  I  +  V A    SG     A     P   ++ S  +
Sbjct: 24  AHAKAILLGEHAVVYGTPALAMPIP-QLAVTASAGWSGR---SAESRGGPTFTMTGSASR 79

Query: 69  IYFETDYGKAAEVLSYVRHAIELVLEEADKRTG--VSVSITSQIPVGAGLGSSAAVAVAT 126
                     A+ L  +R     V        G  + VS+   IP G GLGSSAA A A 
Sbjct: 80  AV-------TAQALDGLRRLTASVKAHTGVTDGQHLDVSLDGAIPPGRGLGSSAANARAI 132

Query: 127 IGAVSKLLDLELSKEEIAKMGHKVELLVQGASSGIDPTVSAIGGFLYYKQGEFEHLPF-V 185
           I A++ L   EL++ E+  +  + E L  G +SG+D         L ++ G  + L    
Sbjct: 133 ILALADLFGRELTEGEVFDLVQEAENLTHGRASGVDAVTVGATAPLLFRAGTAQALDIGC 192

Query: 186 ELPIVVGYTGSSGSTKELVAMVRRRYEEMPELIEPILESMGKLVDKAKEVIISKLDEEEK 245
           +   VV  +G++GSTKE + ++R  +       E  +     LVD A+  +     E E 
Sbjct: 193 DALFVVADSGTAGSTKEAIELLRAGFRAGAGKEERFMHRAAHLVDDARASLAE--GEPEA 250

Query: 246 FLKLGELMNINHGLLDALGVSTKKLSELVYAARTAGAIGAKLTGAGGGGCMYALA-PGKQ 304
           F   G  +   HGLL   G+ST ++  LV AA  A ++GAK+TG G GGC+ A++ P + 
Sbjct: 251 F---GSCLTEYHGLLRGAGLSTDRIDALVDAALQADSLGAKITGGGLGGCVLAMSRPERA 307

Query: 305 REVATAIKIAG 315
            EVA  +  AG
Sbjct: 308 EEVARQLHAAG 318


>gb|AAF58481.1| (AE003821) CG16804 gene product [Drosophila melanogaster]
           Length = 390
           
 Score =  121 bits (300), Expect = 1e-26
 Identities = 114/382 (29%), Positives = 174/382 (44%), Gaps = 58/382 (15%)

Query: 9   APAKIILFGEHSVVYGKPAIASAIDLRTYVR---AEFNDSGNIKIEAHDIKTPGLIVSFS 65
           +P K+IL GEH+VVY +PA+A+ + L T +R    E +   + ++EA +      +  F+
Sbjct: 8   SPGKVILHGEHAVVYHRPALAAVVGLGTTLRFRQLEDSQVASFQLEALNCTLEIQLPEFN 67

Query: 66  EDKIYFETDY--GKAAEVLSYVRHAIELVLEEA--------------------------- 96
                F + Y     A +L  VR  +   LE +                           
Sbjct: 68  GFLAEFRSKYPSDSTANLLEAVRAEVSKQLERSGGNAPKQHTQRAFISIYYLLAGAVLSA 127

Query: 97  --DKR----TGVSVSITSQIPVGAGLGSSAAVAVATIGAVSKLLD--------LELSKEE 142
             DK+    TG  V + SQ+ VGAGLGSSA+   A       L           E ++  
Sbjct: 128 PGDKKLTLQTGFQVQVDSQLTVGAGLGSSASFGAALATTFLILAGHFDRDSYLSEANQAL 187

Query: 143 IAKMGHKVELLVQGASSGIDPTVSAIGGFLYYKQGE-FEHLPFVE-LPIVVGYTGSSGST 200
           I+   ++ E +  G  SG+D TV   GG L Y +G+ F+ L   + L I++  +  S ST
Sbjct: 188 ISSWAYESERVNHGTPSGLDNTVCTYGGMLRYVKGQGFQSLKIQKPLNILLVDSRVSRST 247

Query: 201 KELVAMVRRRYEEMPELIEPILESMGKLVDKAKEVIIS---KLDEEEKFLKLGELMNINH 257
            ++VA VR   +  P+LIE I ++  +LV  A  +  S     D+  KF +L  L  IN+
Sbjct: 248 ADIVAKVRHLGDAFPQLIEAIWQACEELVAAAVPLYESFGNAQDDSSKFEQLERLFQINN 307

Query: 258 GLLDALGVSTKKLSELVYAARTAGAIGAKLTGAGGGGCMYALAPGKQR------EVATAI 311
            LL A+GVS  KL ++   A   G   +KLTGAG GG +  L P          ++   +
Sbjct: 308 DLLKAIGVSHPKLEQIFTIAFKRGFF-SKLTGAGAGGYVIVLLPENYECNEVYWKLKEEL 366

Query: 312 KIAGGTPMITRISKEGLRIEEV 333
           + AG    +T    EGLR+  +
Sbjct: 367 ESAGFGVHVTTAGGEGLRVSSL 388


>gb|AAG02435.1|AF290091_1 (AF290091) mevalonate kinase [Staphylococcus epidermidis]
           Length = 306
           
 Score =  115 bits (286), Expect = 6e-25
 Identities = 99/320 (30%), Positives = 146/320 (44%), Gaps = 30/320 (9%)

Query: 1   MPRLVLASAPAKIILFGEHSVVYGKPAIASAIDL-RTYVRAEFNDSGNIKIEAHDIKTPG 59
           M R     +  KIIL GEH+V +G+PAIA   +  +  V  E  D GN      D+    
Sbjct: 1   MTRQGYGESTGKIILMGEHAVTFGQPAIAIPFNAGKIKVLIESLDEGNYSSITSDVYD-- 58

Query: 60  LIVSFSEDKIYFETDYGKAAEVLSYVRHAIELVLEEADKRTGVSVSITSQIPVGAGLGSS 119
                           G   +   +++  I   +E++  +  +SV I + +P   GLGSS
Sbjct: 59  ----------------GMLYDAPEHLKSIINRFVEKSGVKEPLSVKIQTNLPPSRGLGSS 102

Query: 120 AAVAVATIGAVSKLLDLELSKEEIAKMGHKVELLVQGASSGIDPTVSAIGGFLYYKQGEF 179
           AAVAVA + A    +D  L  + + K  +  E +  G  SGID         +++KQG+ 
Sbjct: 103 AAVAVAFVRASYDFMDQPLDDKTLIKEANWAEQIAHGKPSGIDTQTIVSNKPVWFKQGQA 162

Query: 180 EHLPFVELP--IVVGYTGSSGSTKELVAMVRRRYEEMPELIEPILESMGKLVDKAKEVII 237
           E L  ++L   +VV  TG  GSTK+ V  V    E   +     +E +G LV  A E I 
Sbjct: 163 ETLKSLKLNGYMVVIDTGVKGSTKQAVEDVHVLCES--DEYMKYIEHIGTLVHSASESI- 219

Query: 238 SKLDEEEKFLKLGELMNINHGLLDALGVSTKKLSELVYAARTAGAIGAKLTGAGGGGCMY 297
               E+  F  L ++ N     L  L VS  K+ +L+   +  GAI  KLTG G GG M 
Sbjct: 220 ----EQHDFHHLADIFNACQEDLRHLTVSHDKIEKLLQIGKEHGAIAGKLTGGGRGGSML 275

Query: 298 ALAPGKQ--REVATAIKIAG 315
            LA   +  + +  A++ AG
Sbjct: 276 LLAENLKTAKTIVAAVEKAG 295


>dbj|BAB07790.1| (AB037666) mevalonate kinase [Streptomyces sp. CL190]
           Length = 345
           
 Score =  112 bits (278), Expect = 5e-24
 Identities = 101/318 (31%), Positives = 148/318 (45%), Gaps = 28/318 (8%)

Query: 6   LASAPAKIILFGEHSVVYGKPAIASAIDLRTYVRAEFNDSGNIKIEAHDIK-----TPG- 59
           +  A AK IL GEH+VVYG PA+A  I   T V A    S      A  +      TP  
Sbjct: 31  IGRAHAKAILLGEHAVVYGAPALALPIPQLT-VTASVGWSSEASDSAGGLSYTMTGTPSR 89

Query: 60  LIVSFSEDKIYFETDYGKAAEVLSYVRHAIELVLEEADKRTGVSVSITSQIPVGAGLGSS 119
            +V+ + D ++  T    A   ++   H ++++L+ A             IP G GLGSS
Sbjct: 90  ALVTQASDGLHRLTAEFMARMGVTNAPH-LDVILDGA-------------IPHGRGLGSS 135

Query: 120 AAVAVATIGAVSKLLDLELSKEEIAKMGHKVELLVQGASSGIDPTVSAIGGFLYYKQGEF 179
           AA + A   A++ L   EL++    ++    E +  G +SG+D         L ++QG  
Sbjct: 136 AAGSRAIALALADLFGHELAEHTAYELVQTAENMAHGRASGVDAMTVGASRPLLFQQGRT 195

Query: 180 EHLPF-VELPIVVGYTGSSGSTKELVAMVRRRYEEMPELIEPILESMGKLVDKAKEVIIS 238
           E L    +   +V  +G  GSTKE V M+R  +       E  +    +L + A++ +  
Sbjct: 196 ERLAIGCDSLFIVADSGVPGSTKEAVEMLREGFTRSAGTQERFVGRATELTEAARQALAD 255

Query: 239 KLDEEEKFLKLGELMNINHGLLDALGVSTKKLSELVYAARTAGAIGAKLTGAGGGGCMYA 298
              EE     LG  +   H LL    +ST  +  LV AA  AG++GAK+TG G GGCM A
Sbjct: 256 GRPEE-----LGSQLTYYHELLHEARLSTDGIDALVEAALKAGSLGAKITGGGLGGCMIA 310

Query: 299 LA-PGKQREVATAIKIAG 315
            A P + REV   +  AG
Sbjct: 311 QARPEQAREVTRQLHEAG 328


>gb|AAG02450.1|AF290097_1 (AF290097) mevalonate kinase [Streptococcus pyogenes]
           Length = 292
           
 Score =  110 bits (272), Expect = 3e-23
 Identities = 91/298 (30%), Positives = 137/298 (45%), Gaps = 41/298 (13%)

Query: 9   APAKIILFGEHSVVYGKPAIASAIDLRTYVRAEFNDSGNIKIEAHDIKTPGLIVSFSEDK 68
           A +KIIL GEH+VVYG PAIA  +              +I++  H               
Sbjct: 10  AHSKIILIGEHAVVYGYPAIALPLT-------------DIEVVCH--------------- 41

Query: 69  IYFETDYGKAAEVLSYVRHAIELVLEEADK-RTGVSVSITSQIPVGAGLGSSAAVAVATI 127
             F  D     +    +  AI   L+   + +  ++  I SQ+P   G+GSSAAV++A I
Sbjct: 42  -IFPADKPLVFDFYDTLSTAIYAALDYLQRLQEPIAYEIVSQVPQKRGMGSSAAVSIAAI 100

Query: 128 GAVSKLLDLELSKEEIAKMGHKVELLVQGASSGID-PTVSAIGGFLYYKQGEFEHLPF-V 185
            AV       LS + +  + +K E++     SG+D  T  +     + +   FE +   +
Sbjct: 101 RAVFSYCQEPLSDDLLEILVNKAEIIAHTNPSGLDAKTCLSDHAIKFIRNIGFETIEIAL 160

Query: 186 ELPIVVGYTGSSGSTKELVAMVRRRYEEMPELIEPILESMGKLVDKAKEVIISKLDEEEK 245
              +++  TG  G T+E V     +  +  E   P L  +G L    +  I      ++ 
Sbjct: 161 NGYLIIADTGIHGHTREAV----NKVAQFEETNLPYLAKLGALTQALERAI-----NQKN 211

Query: 246 FLKLGELMNINHGLLDALGVSTKKLSELVYAARTAGAIGAKLTGAGGGGCMYALAPGK 303
            + +G+LM   H  L A+GVS  K  +LV AA  AGA+GAK+TG G GGCM ALA  K
Sbjct: 212 KVAIGQLMTQAHSALKAIGVSISKADQLVEAALRAGALGAKMTGGGLGGCMIALADTK 269


>gb|AAG02430.1|AF290089_1 (AF290089) mevalonate kinase [Staphylococcus haemolyticus]
           Length = 307
           
 Score =  108 bits (267), Expect = 1e-22
 Identities = 94/308 (30%), Positives = 141/308 (45%), Gaps = 27/308 (8%)

Query: 12  KIILFGEHSVVYGKPAIASAIDLRTYVRAEFNDSGNIKIEAHDIKTPGLIVSFSEDKIYF 71
           KIIL GEH+V +G+PAIA               SG +K+    ++      S  +  +Y 
Sbjct: 12  KIILIGEHAVTFGEPAIAIPFT-----------SGKVKVLIESLEKGNY--SAIQSDVYD 58

Query: 72  ETDYGKAAEVLSYVRHAIELVLEEADKRTGVSVSITSQIPVGAGLGSSAAVAVATIGAVS 131
              Y     + S + H +E    E      + + I + +P   GLGSSAAVAVA I A  
Sbjct: 59  GPLYDAPEHLKSLIGHFVENKKVEEP----LLIKIQANLPPSRGLGSSAAVAVAFIRASY 114

Query: 132 KLLDLELSKEEIAKMGHKVELLVQGASSGIDPTVSAIGGFLYYKQGEFEHLPFVELP--I 189
             L L L+ +E+ +     E +  G  SGID         ++Y++GE E L  ++L   +
Sbjct: 115 DYLGLPLTDKELLENADWAERIAHGKPSGIDTKTIVTNQPVWYQKGEVEILKTLDLDGYM 174

Query: 190 VVGYTGSSGSTKELVAMVRRRYEEMPELIEPILESMGKLVDKAKEVIISKLDEEEKFLKL 249
           VV  TG  GSTK+ V  V +  +     ++ +++ +G LV  A E I     E   F +L
Sbjct: 175 VVIDTGVKGSTKQAVEDVHQLCDNDKNYMQ-VVKHIGSLVYSASEAI-----EHHSFDQL 228

Query: 250 GELMNINHGLLDALGVSTKKLSELVYAARTAGAIGAKLTGAGGGGCMYALAPGKQ--REV 307
             + N     L  L VS  K+   +      G++  KLTG G GG M  LA   Q  + +
Sbjct: 229 ATIFNQCQDDLRTLTVSHDKIEMFLRLGEENGSVAGKLTGGGRGGSMLILAKELQTAKNI 288

Query: 308 ATAIKIAG 315
             A++ AG
Sbjct: 289 VAAVEKAG 296


>gb|AAG02455.1|AF290099_1 (AF290099) mevalonate kinase [Streptococcus pneumoniae]
           Length = 292
           
 Score = 92.8 bits (227), Expect = 5e-18
 Identities = 87/297 (29%), Positives = 142/297 (47%), Gaps = 41/297 (13%)

Query: 6   LASAPAKIILFGEHSVVYGKPAIASAIDLRTYVRAEFNDSGNIKIEAHDIKTPGLIVSFS 65
           +  A +KIIL GEH+VVYG PAI+  +               +++E     T  ++ + S
Sbjct: 7   VGQAHSKIILIGEHAVVYGYPAISLPL---------------LEVEV----TCKVVSAES 47

Query: 66  EDKIYFETDYGKAAEVLSYVRHAIELVLEEAD-KRTGVSVSITSQIPVGAGLGSSAAVAV 124
             ++Y E       + LS    A+   LE  D     V   I S IP   G+GSSAA+++
Sbjct: 48  PWRLYEE-------DTLSM---AVYASLEYLDITEACVRCEIDSAIPEKRGMGSSAAISI 97

Query: 125 ATIGAVSKLLDLELSKEEIAKMGHKVELLVQGASSGIDP-TVSAIGGFLYYKQGEFEHLP 183
           A I AV      +L  + +  + ++ E++     SG+D  T  +     + K   F  L 
Sbjct: 98  AAIRAVFDYYQADLPHDVLEILVNRAEMIAHMNPSGLDAKTCLSDQPIRFIKNVGFTELE 157

Query: 184 F-VELPIVVGYTGSSGSTKELVAMVRRRYEEMPELIEPILESMGKLVDKAKEVIISKLDE 242
             +   +V+  TG  G T+E + +V+ + ++      P L ++G+L  +A+  I  K  E
Sbjct: 158 MDLSAYLVIADTGVYGHTREAIQVVQNKGKDAL----PFLHALGELTQQAEVAISQKYAE 213

Query: 243 EEKFLKLGELMNINHGLLDALGVSTKKLSELVYAARTAGAIGAKLTGAGGGGCMYAL 299
                 LG + +  H  L  +GVS+ +   LV  A + GA+GAK++G G GGC+ AL
Sbjct: 214 G-----LGLIFSQAHLHLKEIGVSSPEADFLVETALSYGALGAKMSGGGLGGCIIAL 265


>gb|AAG28454.1|AF195244_1 (AF195244) galactokinase [Pyrococcus furiosus]
           Length = 352
           
 Score = 91.3 bits (223), Expect = 1e-17
 Identities = 91/343 (26%), Positives = 150/343 (43%), Gaps = 55/343 (16%)

Query: 5   VLASAPAKIILFGEHSVVYGKPAIASAIDLRTYVRAEFNDSGNIKIEAHDIKTPGLIVSF 64
           +   +P ++ L GEH+       +  AIDL T + AE  D   +  E            F
Sbjct: 4   ITVKSPGRVNLIGEHTDYTYGYVMPMAIDLYTIITAEKYDKVQLYSE-----------HF 52

Query: 65  SEDKIYFETDYGKAAEVLSYVRHAIELVLEEADKRTGVSVSITSQIPVGAGLGSSAAVAV 124
           +E+K +   +  K    + YV+  + ++++E  K  G+   IT  +P+GAGL SSA+  V
Sbjct: 53  NEEKTFTLDNLTKEGSWIDYVKGVLWVLIQEGYKIGGLKGKITGDLPLGAGLSSSASFEV 112

Query: 125 ATIGAVSKLLDLELSKEEIAKMGHKVELLVQGASSGIDPTVSAIGG------FLYYKQGE 178
             +  +++L +L +   + A +  K E    G   GI    + + G      FL  +  +
Sbjct: 113 GILEVLNQLYNLNIDPLKKALLAKKAENEFVGVPCGILDQFAVVFGKKDNVIFLDTQTLQ 172

Query: 179 FEHLPF-VELPIVVGYTGSSGSTKELVAMVRRRYEEMPELIEPILESMGKLVDKAKEVII 237
           +E++PF  ++ ++V YTG     +EL +     Y E   + E  L  +GK  + +KEV  
Sbjct: 173 YEYIPFPKDVSVLVFYTGVK---RELAS---SEYAERKRIAEESLRILGK--ESSKEVTE 224

Query: 238 SKLDE----EEKFL-----------------------KLGELMNINH-GLLDALGVSTKK 269
             L +      KF                        K+G+++   H  L +   VS ++
Sbjct: 225 KDLGKLPPLHRKFFSYIVRENARVLEVRDALKEGDIEKVGKILTTAHWDLAENYRVSCEE 284

Query: 270 LSELVYAARTAGAIGAKLTGAGGGGCMYALA-PGKQREVATAI 311
           L   V  A   GA GA+LTGAG GG   AL    K + +  AI
Sbjct: 285 LDFFVKKAMELGAYGARLTGAGFGGSAIALVDKDKAKTIGDAI 327


>sp|Q9RGS1|GAL1_STACA GALACTOKINASE (GALACTOSE KINASE)
           >gi|6707009|gb|AAF25548.1|AF109295_3 (AF109295) GalK
           [Staphylococcus carnosus]
           Length = 388
           
 Score = 84.3 bits (205), Expect = 2e-15
 Identities = 84/336 (25%), Positives = 150/336 (44%), Gaps = 48/336 (14%)

Query: 5   VLASAPAKIILFGEHSVVYGKPAIASAIDLRTYVRAEFNDSGNIKIEAHDIKTPGLIVSF 64
           V A AP +I L GEH+   G     +AI+L TY  A   +   I + +++ ++ G I  F
Sbjct: 19  VAAFAPGRINLIGEHTDYNGGYVFPAAIELGTYGLASKRNDNKICLYSNNFESTGTI-EF 77

Query: 65  SEDKIYFETDYGKAAEVLSYVRHAIELVLEEADK-RTGVSVSITSQIPVGAGLGSSAAVA 123
           S D++ F+T +  A    +Y +  ++ + E   +  +G ++ I   IP GA L SSA++ 
Sbjct: 78  SLDELQFDTTHSWA----NYPKGMVKFLKESGYQIDSGFNILIEGNIPNGASLSSSASIE 133

Query: 124 VATIGAVSKLLDLELSKEEIAKMGHKVELLVQGASSGI-DPTVSAIGG-----FLYYKQG 177
           +     +  L +LE+ + E+ ++G KVE    G +SGI D  +  +G       L     
Sbjct: 134 ILMGWLLKALFNLEVERLELIELGRKVENQFIGVNSGIMDQFIVGMGRKDQAILLDTATL 193

Query: 178 EFEHLPFVELPIVVGYTGSSGSTKELVAMVRRRYEEMPELI-----EPILESMGK----- 227
           E+ ++P      V+    ++   +   +    R +E    +     E  ++++G      
Sbjct: 194 EYHYVPTEFGDYVISIMNTNKRRELAESKYNERLKECQSALALLQQELDVDALGHIDVTT 253

Query: 228 ------------LVDKAKEVIISKLDEEE--------KFLKLGELMNINHGLL----DAL 263
                       L+ +A+  I      +E         F++ G L+N +H  L    +  
Sbjct: 254 FEKHAYLIEEDVLLRRARHAITENARVKEAHAALNRKDFIEFGRLLNASHASLKNDYEVT 313

Query: 264 GVSTKKLSELVYAARTAGAIGAKLTGAGGGGCMYAL 299
           G+    L+E   A +  G +GA++TGAG  GC  AL
Sbjct: 314 GIELDTLAET--AQQVEGVLGARMTGAGFAGCAIAL 347


>dbj|BAB07819.1| (AB037907) phosphomevalonate kinase [Streptomyces griseolosporeus]
           Length = 360
           
 Score = 82.3 bits (200), Expect = 7e-15
 Identities = 104/373 (27%), Positives = 156/373 (40%), Gaps = 64/373 (17%)

Query: 2   PRLVLASAPAKIILFGEHSVVY-GKPAIASAIDLRTYVRAEFNDSGNIKIEAHDIKTPGL 60
           PR V   AP K+ + GE++VV  G  AI  A+D   YV    +D             PG+
Sbjct: 4   PRAVTRRAPGKLFVAGEYAVVEPGNRAILVAVD--RYVTVTVSDGA----------APGV 51

Query: 61  IVS--FSEDKIYFETDYGKAA------EVLSYVRHAIELVLEEADKRTGVSVSITSQIPV 112
           +VS       ++     G+         V++ V     L+ E       +  SI+S +  
Sbjct: 52  VVSSDIGAGPVHHPWQDGRLTGGTGTPHVVAAVETVARLLAERGRSVPPLGWSISSTLHE 111

Query: 113 GA---GLGSSAAVAVATIGAVSKLLDLELSKEEIAKMGHKVELLVQGASSGIDPTVSAIG 169
                GLGSS AV VAT+ AV+    LEL+ EE  +        +    SG D   S  G
Sbjct: 112 DGRKFGLGSSGAVTVATVSAVAAHCGLELTAEERFRTALIASARIDPRGSGGDIATSTWG 171

Query: 170 GFLYY-------------KQGEFEHL------------PFVELPIVVGYTGSSGSTKELV 204
           G++ Y             +QG  E L            P   L + VG+TG+  ST  L+
Sbjct: 172 GWIAYRAPDRDAVLDLTRRQGVDEALRAPWPGFSVRLSPPRNLCLEVGWTGNPVSTTSLL 231

Query: 205 AMVRRRYEEMPELIEPILESMGKLVDKAKEVIISKLDEEEKFLKLGELMNINHGLLD--- 261
             + RR           + + G+LVD A   +I+  D + + L L ++    H ++    
Sbjct: 232 TDLHRRTWRGSPAYRRYVGATGELVDAA---VIALEDGDTEGL-LRQVRRARHEMVRLDD 287

Query: 262 --ALGVSTKKLSELVYAARTAGAIGAKLTGAGGGGCMYALAPGKQREVATAI----KIAG 315
              LG+ T +L+ L   A  AGA  AK +GAGGG C  AL   + R   + +      AG
Sbjct: 288 EVGLGIFTPELTALCAIAERAGA--AKPSGAGGGDCGIALLDAEARYDRSPLHRQWAAAG 345

Query: 316 GTPMITRISKEGL 328
             P++   + EG+
Sbjct: 346 VLPLLVSPATEGV 358


>sp|O58107|GAL1_PYRHO PROBABLE GALACTOKINASE (GALACTOSE KINASE) >gi|7434202|pir||F71144
           probable galactokinase - Pyrococcus horikoshii
           >gi|3256760|dbj|BAA29443.1| (AP000002) 350aa long
           hypothetical galactokinase [Pyrococcus horikoshii]
           Length = 350
           
 Score = 80.4 bits (195), Expect = 3e-14
 Identities = 90/337 (26%), Positives = 144/337 (42%), Gaps = 52/337 (15%)

Query: 4   LVLASAPAKIILFGEHSVVYGKPAIASAIDLRTYVRAEFNDSGNIKIEAHDIKTPGLIVS 63
           ++   +P ++ L GEH+       +  AI+L T + AE +    +  E            
Sbjct: 1   MIKVKSPGRVNLIGEHTDYTYGYVMPMAINLYTKIEAEKHGEVILYSE-----------H 49

Query: 64  FSEDKIYFETDYGKAAEVLSYVRHAIELVLEEADKRTG-VSVSITSQIPVGAGLGSSAAV 122
           F E++ +   D  K    + YV+  I  VL+E+D   G +   ++  +P+GAGL SSA+ 
Sbjct: 50  FGEERKFSLNDLRKENSWIDYVK-GIFWVLKESDYEVGGIKGRVSGNLPLGAGLSSSASF 108

Query: 123 AVATIGAVSKLLDLELSKEEIAKMGHKVELLVQGASSGIDPTVSAIGG------FLYYKQ 176
            V  +  + KL +L+L       +  K E    G   GI    + + G      FL    
Sbjct: 109 EVGILETLDKLYNLKLDSLSKVLLAKKAENEFVGVPCGILDQFAVVFGREGNVIFLDTHT 168

Query: 177 GEFEHLPF-VELPIVVGYTGSSGSTKELVAMVRRRYEEMPELIEPILESMGKLVDK-AKE 234
            ++E++PF  ++ I+V YT   G  +EL +     Y E   + E  L+ +GK   K  +E
Sbjct: 169 LDYEYIPFPKDVSILVFYT---GVRRELAS---SEYAERKHIAEESLKILGKGSSKEVRE 222

Query: 235 VIISKLD------------------------EEEKFLKLGELMNINH-GLLDALGVSTKK 269
             +SKL                         +E    ++G+++   H  L     VS K+
Sbjct: 223 GELSKLPPLHRKFFGYIVRENARVLEVRDALKEGNVEEVGKILTTAHWDLAKNYEVSCKE 282

Query: 270 LSELVYAARTAGAIGAKLTGAGGGGCMYALAPGKQRE 306
           L   V  A   GA GA+LTGAG GG   AL   +  E
Sbjct: 283 LDFFVERALKLGAYGARLTGAGFGGSAIALVDKEDAE 319


>sp|O85253|GAL1_THENE GALACTOKINASE (GALACTOSE KINASE) >gi|3252901|gb|AAC24222.1|
           (AF055482) galactose kinase [Thermotoga neapolitana]
           Length = 350
           
 Score = 74.9 bits (181), Expect = 1e-12
 Identities = 87/321 (27%), Positives = 140/321 (43%), Gaps = 42/321 (13%)

Query: 9   APAKIILFGEHSVVYGKPAIASAIDLRTYVRAEFNDSGNIKIEAHDIKTPGLIVSFSEDK 68
           AP +I + GEH+       +  A++   ++  E  DSG  K   H       +     +K
Sbjct: 5   APGRINIIGEHTDYNDGYVLPFAVNRFVFLTIE--DSG--KFVFHSENMNETVEMEKIEK 60

Query: 69  IYFETDYGKAAEVLSYVRHAIELVLEEADKRTGVSVSITSQIPVGAGLGSSAAVAVATIG 128
           +   TDY      +S V  A E   +   K + V +S++S +P+GAGL SSAA+ +AT  
Sbjct: 61  LNRWTDY------ISGVIKAFE---KRGYKVSPVKISVSSNLPMGAGLSSSAALEMATAY 111

Query: 129 AVSKLLDLELSKEEIAKMGHKVELLVQGASSGI-DPTVSAIGG-----FLYYKQGEFEHL 182
           A+S+     L K E+ K+  + E+   G   GI D   SA G      FL     E+E++
Sbjct: 112 AISEHFGFHLPKLELVKIAREAEVEFVGVRCGIMDQFTSAFGKKDHAIFLDTMTLEYEYV 171

Query: 183 PFVELPIVVGYTGSSGSTKELVAMVRRRYEEMPELI---------EPILESMGKLVDKAK 233
           P       +    S+   +   +   +R +E  E++         E   E + KL D  K
Sbjct: 172 PLKLEGYEINLVDSNVKHELSSSEYNKRRQECEEVLRVLGKRSFREVTKEDLKKLPDVLK 231

Query: 234 EVIISKLDEEEKFLK------------LGELMNINH-GLLDALGVSTKKLSELV-YAART 279
           +     L+E E+ LK            LG L+  +H  L D   VS ++   +V +    
Sbjct: 232 KRAQHVLEENERVLKSVQALKEGDFETLGRLLFSSHESLRDLYEVSCEQTDFIVDFLKGR 291

Query: 280 AGAIGAKLTGAGGGGCMYALA 300
            G +GA++ G G GG +  L+
Sbjct: 292 EGILGARMVGGGFGGGVIVLS 312


>pir||G70185 mevalonate kinase homolog - Lyme disease spirochete
           >gi|2688613|gb|AAC67029.1| (AE001169) mevalonate kinase
           [Borrelia burgdorferi]
           Length = 297
           
 Score = 73.7 bits (178), Expect = 3e-12
 Identities = 72/294 (24%), Positives = 124/294 (41%), Gaps = 41/294 (13%)

Query: 10  PAKIILFGEHSVVYGKPAIASAIDLRTYVRAEFNDSGNIKIEAHDIKTPGLIVSFSEDKI 69
           PAKI+  GEHS VYG P I + + +                         LI S S++  
Sbjct: 7   PAKILFLGEHSAVYGFPVIGATVPIYM----------------------DLIYSVSKNWK 44

Query: 70  YFETDYGKAAEVLSYVRHAIELVLEEADKRTGVSVSITSQIPVGAGLGSSAAVAVATIGA 129
           Y     GK +  L+ +   I  ++    K   +   I S+IP+G GLGSSA++++     
Sbjct: 45  YL----GKPSTRLNSL---ISFIVSNYSKVNPIEFDIISEIPIGVGLGSSASLSLCFAEY 97

Query: 130 VSKLLDLELSKEEIAKMGHKVELLVQGASSGIDPTVSAIGGFLYYKQGE----FEHLPFV 185
           ++   + +   + +  + +++E +  G SSG+D  +  + G  Y ++ E     + +   
Sbjct: 98  ITSHFEYKDCNKIL--LANQIENIFHGKSSGMDIRLIDLNGTFYLEKKENVLHSKKIKDS 155

Query: 186 ELPIVVGYTGSSGSTKELVAMVRRRYEEMPELIEPILESMGKLVDKAKEVIISKLDEEEK 245
               ++G      +TKE+V  +++       L    +E +G  V  +         + + 
Sbjct: 156 GFYFLIGAIKRDLTTKEIVVNLKKDLLSNAYLF-VFIEKLGLAVSNSYASF-----QNKD 209

Query: 246 FLKLGELMNINHGLLDALGVSTKKLSELVYAARTAGAIGAKLTGAGGGGCMYAL 299
              L   MNI    L  LG+S   L  L+      GA+  KL+GAG GG    L
Sbjct: 210 VYSLANEMNIAQCCLKRLGLSNDTLDWLISEGIKLGALSGKLSGAGKGGAFIFL 263


>gb|AAK43093.1| (Phospho) mevalonate kinase, putative [Sulfolobus solfataricus]
           Length = 323
           
 Score = 72.6 bits (175), Expect = 6e-12
 Identities = 90/350 (25%), Positives = 149/350 (41%), Gaps = 51/350 (14%)

Query: 4   LVLASAPAKIILFGEHSVVYGKPAIASAIDLRTYVRAEFNDSGNIKIEAHDIKTPGLIVS 63
           ++  SAP KI+  G +SVV+G  +   A++ R            +     +IK       
Sbjct: 1   MIKVSAPGKILWIGSYSVVFGGISHVIAVNKR------------VSCSLREIK------- 41

Query: 64  FSEDKIYFETDYG----KAAEVLSYVRHAIELVLEEADKRTGVSVSITSQIPVGA---GL 116
             +D + F T YG       E+++ V       L +  +   + +    +  +     GL
Sbjct: 42  -EKDSLIFHTSYGHFKNSGNELINSVLDTFRERLSQLPQGYEIDLYNDKEFIIDGKKTGL 100

Query: 117 GSSAAVAVATIGAVSKLLDLELSKEEIAKMGHKVELLVQ-GASSGIDPTVSAIGGFLYYK 175
           GSS+A  V+    +   +  +L   EI K+        Q G  SG D   SA+ G + YK
Sbjct: 101 GSSSAATVSLTACLYYAIHGKLDLFEIHKLAQIANYKRQKGIGSGFD-IASAVFGSIVYK 159

Query: 176 QGE--------FEHLPFVELPIVVGYTGSSGSTKELVAMVRRRYEEMPELIEPILESMGK 227
           +          FE L      +++G+TG S  T  LV    R++ E   L +   + + +
Sbjct: 160 RFTDLDKMDFYFEKLNLGNYDMMLGFTGKSSETVGLV----RKFVEKSNLDD--FKEIMR 213

Query: 228 LVDKA-----KEVIISKLDEEEKFLKLG-ELMNINHGLLDALGVSTKKLSELVYAARTAG 281
           L+D+      K + ++KLDE  + +KLG + +N     +  + + +K   EL+  A   G
Sbjct: 214 LIDEENYMAIKLIKLNKLDEAVEHIKLGRKYLNYIAERIVGVKLVSKMEEELIKIAEEEG 273

Query: 282 AIGAKLTGAGGGGCMYALAPGKQREVATAIKIAGGTPMITRISKEGLRIE 331
           A+ A   GAGGG  ++AL     R      K   G  +I     EGLR+E
Sbjct: 274 ALVALSPGAGGGDSIFALGNDLNRVREAWSK--RGIFIIDVKEDEGLRLE 321


>sp|P56838|GAL1_THEMA GALACTOKINASE >gi|7434204|pir||C72283 galactokinase - Thermotoga
           maritima (strain MSB8)
           >gi|4981741|gb|AAD36265.1|AE001776_1 (AE001776)
           galactokinase [Thermotoga maritima]
           Length = 350
           
 Score = 72.2 bits (174), Expect = 8e-12
 Identities = 80/325 (24%), Positives = 138/325 (41%), Gaps = 50/325 (15%)

Query: 9   APAKIILFGEHSVVYGKPAIASAIDLRTYVRAEFNDSGNIKIEAHDIKTPGLIVSFSEDK 68
           AP +I + GEH+       +  A++   ++  E    G+ +   H       +     +K
Sbjct: 5   APGRINIIGEHTDYNDGYVLPFAVNRYVFLSIE----GSERFIFHSENVNETVEMEKIEK 60

Query: 69  IYFETDYGKAAEVLSYVRHAIELVLEEADKR----TGVSVSITSQIPVGAGLGSSAAVAV 124
           +   TDY             I  V+   +KR    + V +S++S +P+GAGL SSAA+ V
Sbjct: 61  LNKWTDY-------------ISGVIASFEKRGYRVSPVKISVSSNLPIGAGLSSSAALEV 107

Query: 125 ATIGAVSKLLDLELSKEEIAKMGHKVELLVQGASSGIDPTVSAIGG------FLYYKQGE 178
           AT  A+S+     + K E+ K+  + E+   G   GI    +A+ G      FL     E
Sbjct: 108 ATAYAISEYFGFNVPKLELVKIAREAEVEFVGVRCGIMDQFTAVFGKKDHAIFLDTMTLE 167

Query: 179 FEHLPFVELPIVVGYTGSSGSTKELVAMVRRRYEEMPELI---------EPILESMGKLV 229
           +E++P       +    S+   +   +   RR +E  E++         E   E + +L 
Sbjct: 168 YEYVPLKLEGYEINLVDSNVKHELSSSEYNRRRQECEEVLKTLEKKSFREVTKEDLERLS 227

Query: 230 DKAKEVIISKLDEEEKFLK------------LGELMNINH-GLLDALGVSTKKLSELV-Y 275
              ++     L+E E+ LK            LG+L+  +H  L D   VS ++   +V Y
Sbjct: 228 GTLRKRAQHVLEENERVLKSVQALKEGDFETLGKLLFSSHESLRDLYEVSCEETDFIVDY 287

Query: 276 AARTAGAIGAKLTGAGGGGCMYALA 300
                G +GA++ G G GG +  L+
Sbjct: 288 LRGKEGILGARMVGGGFGGGVIVLS 312


>gb|AAG02447.1|AF290095_3 (AF290095) phosphomevalonate kinase [Enterococcus faecium]
           Length = 361
           
 Score = 72.2 bits (174), Expect = 8e-12
 Identities = 89/335 (26%), Positives = 150/335 (44%), Gaps = 56/335 (16%)

Query: 4   LVLASAPAKIILFGEHSVVY-GKPAIASAIDLRTYVRAEF-NDSGNIKIEAHDIKTPGLI 61
           ++  SAP K+ + GE++VV  G PA+ +A+D    V  E     G+I+   +     G+ 
Sbjct: 1   MIEVSAPGKLYIAGEYAVVETGHPAVIAAVDQFVTVTVESARKVGSIQSAQYS----GMP 56

Query: 62  VSFSEDKIYFETDYGKAAEVLSYVRHAIELVLEEADKRTGV----SVSITSQIPVGAG-- 115
           V ++        D  +      Y+  AI L  + A ++  +     + +TS++    G  
Sbjct: 57  VRWTRRNGELVLDIRE--NPFHYILAAIRLTEKYAQEKNILLSFYDLKVTSELDSSNGRK 114

Query: 116 --LGSSAAVAVATIGAVSKLLDLELSKEEIAKMGHKVELLVQGASSGIDPTVSAIGGFLY 173
             LGSS AV VAT+ A++    L LS+ EI K+     L VQ   S  D   S  GG++ 
Sbjct: 115 YGLGSSGAVTVATVKALNVFYALNLSQLEIFKIAALANLAVQDNGSCGDIAASCYGGWIA 174

Query: 174 Y--------KQGEFEHL---------------PFV---ELPIVVGYTGSSGSTKELVAMV 207
           +        ++ E +H                P +   +L +++G+TGS  ST +LV  V
Sbjct: 175 FSTFDHPWLQEQETQHSISELLALDWPGLSIEPLIAPEDLRLLIGWTGSPASTSDLVDQV 234

Query: 208 RRRYEEMPELIEPILESMGKLVDKAKEVIISKLDEEEKFLKLGELMNINHGLLDALG--- 264
            R  E+     +  L++  + V++     + K  +E     + +++  N  LL  L    
Sbjct: 235 HRSREDKMVAYQLFLKNSTECVNE-----MIKGFKENNVTLIQQMIRKNRQLLHDLSAIT 289

Query: 265 ---VSTKKLSELV-YAARTAGAIGAKLTGAGGGGC 295
              + T  L++L   A +  GA  AK +GAGGG C
Sbjct: 290 GVVIETPALNKLCNLAEQYEGA--AKSSGAGGGDC 322


>gb|AAG02426.1|AF290087_3 (AF290087) phosphomevalonate kinase [Staphylococcus aureus]
           Length = 358
           
 Score = 71.4 bits (172), Expect = 1e-11
 Identities = 84/330 (25%), Positives = 143/330 (42%), Gaps = 44/330 (13%)

Query: 4   LVLASAPAKIILFGEHSVVY-GKPAIASAIDLRTYVRAEFNDSGNIKIEAHDIKTPGLIV 62
           ++   AP K+ + GE++V   G  ++  A+D   +V A   ++   K   H        V
Sbjct: 1   MIQVKAPGKLYIAGEYAVTEPGYKSVLIALD--RFVTATIEEATQYKGTIHSKALHHNPV 58

Query: 63  SFSEDKIYFETDYGKAAEVLSYVRHAIELVLEEADKRTGVSV-----SITSQIPVGAG-- 115
           +FS D+         AA+ L+YV  AIE + E+  K   +++     +I S +    G  
Sbjct: 59  TFSRDEDSIVISDPHAAKQLNYVVTAIE-IFEQYAKSCDIAMKHFHLTIDSNLDDSNGHK 117

Query: 116 --LGSSAAVAVATIGAVSKLLDLELSKEEIAKMGHKVELLVQGASSGIDPTVSAIGGFLY 173
             LGSSAAV V+ I  +++  D++LS   I K+     + +Q  SS  D  VS   G+L 
Sbjct: 118 YGLGSSAAVLVSVIKVLNEFYDMKLSNLYIYKLAVIANMKLQSLSSCGDIAVSVYSGWLA 177

Query: 174 YKQGEFE----------------------HLPFVELP----IVVGYTGSSGSTKELVAMV 207
           Y   + E                      H+  ++ P    +++G+TGS  S+   V+ V
Sbjct: 178 YSTFDHEWVKHQIEDTTVEEVLIKNWPGLHIEPLQAPENMEVLIGWTGSPASSPHFVSEV 237

Query: 208 RRRYEEMPELIEPILESMGKLVDKAKEVI-ISKLDEEEKFLKLGELMNINHGLLDALGVS 266
           +R   + P      LE   + V+K       + +   +K ++    +         + + 
Sbjct: 238 KRLKSD-PSFYGDFLEDSHRCVEKLIHAFKTNNIKGVQKMVRQNRTIIQRMDKEATVDIE 296

Query: 267 TKKLSELV-YAARTAGAIGAKLTGAGGGGC 295
           T+KL  L   A +  GA  +K +GAGGG C
Sbjct: 297 TEKLKYLCDIAEKYHGA--SKTSGAGGGDC 324


>gb|AAG02437.1|AF290091_3 (AF290091) phosphomevalonate kinase [Staphylococcus epidermidis]
           Length = 358
           
 Score = 70.2 bits (169), Expect = 3e-11
 Identities = 80/329 (24%), Positives = 142/329 (42%), Gaps = 42/329 (12%)

Query: 4   LVLASAPAKIILFGEHSVVYGKPAIASA-IDLRTYVRAEFNDSGNIKIEAHDIKTPGLIV 62
           ++   AP K+ + GE++V   +P   S  I +  +V A    S  ++   H        V
Sbjct: 1   MIQVKAPGKLYIAGEYAVT--EPGYKSILIAVNRFVTATIEASNKVEGSIHSKTLHYEPV 58

Query: 63  SFSEDKIYFETDYGKAAEVLSYVRHAIELVLEEADKRTGVSV-----SITSQIPVGAG-- 115
            F  ++   E    +AA+ L YV  AIE V E+  +   +++     +I S +   +G  
Sbjct: 59  KFDRNEDRIEISDVQAAKQLKYVVTAIE-VFEQYVRSCNMNLKHFHLTIDSNLADNSGQK 117

Query: 116 --LGSSAAVAVATIGAVSKLLDLELSKEEIAKMGHKVELLVQGASSGIDPTVSAIGGFLY 173
             LGSSAAV V+ + A+++   LELS   I K+     + +Q  SS  D  VS   G+L 
Sbjct: 118 YGLGSSAAVLVSVVKALNEFYGLELSNLYIYKLAVIANMKLQSLSSCGDIAVSVYSGWLA 177

Query: 174 YKQGEFE----------------------HLPFVELP----IVVGYTGSSGSTKELVAMV 207
           Y   + +                      H+  ++ P    +++G+TGS  S+  LV+ V
Sbjct: 178 YSTFDHDWVKQQMEETSVNDVLEKNWPGLHIEPLQAPENMEVLIGWTGSPASSPHLVSEV 237

Query: 208 RRRYEEMPELIEPILESMGKLVDKAKEVI-ISKLDEEEKFLKLGELMNINHGLLDALGVS 266
           +R   + P      L+     V+   +    + +   +K +++   +  +     ++ + 
Sbjct: 238 KRLKSD-PSFYGDFLDQSHACVESLIQAFKTNNIKGVQKMIRINRRIIQSMDNEASVEIE 296

Query: 267 TKKLSELVYAARTAGAIGAKLTGAGGGGC 295
           T KL +L       G   +K +GAGGG C
Sbjct: 297 TDKLKKLCDVGEKHGG-ASKTSGAGGGDC 324


>gb|AAG02432.1|AF290089_3 (AF290089) phosphomevalonate kinase [Staphylococcus haemolyticus]
           Length = 358
           
 Score = 69.5 bits (167), Expect = 5e-11
 Identities = 83/335 (24%), Positives = 143/335 (41%), Gaps = 46/335 (13%)

Query: 4   LVLASAPAKIILFGEHSVVY-GKPAIASAIDLRTYVRAEFNDSGNIKIEAHDIKTPGLIV 62
           ++   AP K+ + GE++V   G  ++  A+D       E +++    I +  +    +  
Sbjct: 1   MIQVKAPGKLYVAGEYAVTEPGYKSVLIAVDRFVTASIEASNAVTSTIHSKTLHYEPVTF 60

Query: 63  SFSEDKIYFETDYGKAAEVLSYVRHAIELVLEEADKRTGVSVS-----ITSQIPVGAG-- 115
           + +EDKI  +     AA  L YV  AIE V E+  +   V +      I S +   +G  
Sbjct: 61  NRNEDKI--DISDANAASQLKYVVTAIE-VFEQYARSCNVKLKHFHLEIDSNLDDASGNK 117

Query: 116 --LGSSAAVAVATIGAVSKLLDLELSKEEIAKMGHKVELLVQGASSGIDPTVSAIGGFLY 173
             LGSSAAV V+ + A+++  D++LS   I K+     + +Q  SS  D  VS   G+L 
Sbjct: 118 YGLGSSAAVLVSVVKALNEFYDMQLSNLYIYKLAVISNMRLQSLSSCGDIAVSVYSGWLA 177

Query: 174 YKQGEFE----------------------HLPFVELP----IVVGYTGSSGSTKELVAMV 207
           Y   + +                      H+  ++ P    +++G+TGS  S+  LV+ V
Sbjct: 178 YSTFDHDWVKQQMEETSVNEVLEKNWPGLHIEPLQAPENMEVLIGWTGSPASSPHLVSEV 237

Query: 208 RRRYEEMPELIEPILESMGKLVDKAKEVIISKLDE---EEKFLKLGELMNINHGLLDALG 264
           +R   + P      L+     V+    +   K D     +K ++   ++         + 
Sbjct: 238 KRLKSD-PSFYGRFLDQSHTCVENL--IYAFKTDNIKGVQKMIRQNRMIIQQMDNEATVD 294

Query: 265 VSTKKLSELVYAARTAGAIGAKLTGAGGGGCMYAL 299
           + T+ L  L       GA  AK +GAGGG C  A+
Sbjct: 295 IETENLKMLCDIGERYGA-AAKTSGAGGGDCGIAI 328


  Database: ./suso.pep
    Posted date:  Jul 6, 2001  5:57 PM
  Number of letters in database: 840,471
  Number of sequences in database:  2977
  
  Database: /banques/blast2/nr.pep
    Posted date:  Dec 14, 2000 12:46 PM
  Number of letters in database: 188,266,275
  Number of sequences in database:  595,510
  
Lambda     K      H
   0.315    0.135    0.365 

Gapped
Lambda     K      H
   0.270   0.0470    0.230 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 114854776
Number of Sequences: 2977
Number of extensions: 4726031
Number of successful extensions: 14356
Number of sequences better than 1.0e-10: 40
Number of HSP's better than  0.0 without gapping: 8
Number of HSP's successfully gapped in prelim test: 32
Number of HSP's that attempted gapping in prelim test: 14247
Number of HSP's gapped (non-prelim): 57
length of query: 335
length of database: 189,106,746
effective HSP length: 61
effective length of query: 274
effective length of database: 152,599,039
effective search space: 41812136686
effective search space used: 41812136686
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 42 (22.0 bits)
S2: 165 (68.7 bits)