BLASTP 2.0.10 [Aug-26-1999]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= PAB0391 (gdh) DE:Glutamate dehydrogenase (NAD(P)+)
(420 letters)
Database: ./suso.pep; /banques/blast2/nr.pep
598,487 sequences; 189,106,746 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
sp|Q47950|DHE3_PYRAB GLUTAMATE DEHYDROGENASE (GDH) >gi|7431770|p... 859 0.0
pir||A71038 probable glutamate dehydrogenase - Pyrococcus horiko... 850 0.0
sp|O52310|DHE3_PYRHO GLUTAMATE DEHYDROGENASE (GDH) >gi|2828004|g... 850 0.0
sp|Q47951|DHE3_PYREN GLUTAMATE DEHYDROGENASE (GDH) >gi|464224|gb... 846 0.0
pir||A47410 glutamate dehydrogenase (NAD(P)+) (EC 1.4.1.3) - Pyr... 843 0.0
sp|P80319|DHE3_PYRFU GLUTAMATE DEHYDROGENASE (GDH) >gi|11374956|... 837 0.0
pdb|1GTM|A Chain A, Structure Of Glutamate Dehydrogenase >gi|194... 833 0.0
sp|Q56304|DHE3_THELI GLUTAMATE DEHYDROGENASE (GDH) >gi|310891|gb... 769 0.0
pdb|1BVU|A Chain A, Glutamate Dehydrogenase From Thermococcus Li... 767 0.0
sp|O74024|DHE3_THEPR GLUTAMATE DEHYDROGENASE (GDH) >gi|11252782|... 741 0.0
sp|O59650|DHE3_PYRKO GLUTAMATE DEHYDROGENASE (GDH) >gi|11252762|... 735 0.0
emb|CAC11907.1| (AL445065) probable glutamate dehydrogenase [The... 531 e-150
emb|CAC11774.1| (AL445064) probable glutamate dehydrogenase [The... 515 e-145
gb|AAA64796.1| (L19116) glutamate dehydrogenase [Pyrococcus abyssi] 483 e-135
pdb|2TMG|A Chain A, Thermotoga Maritima Glutamate Dehydrogenase ... 474 e-133
pdb|1B3B|A Chain A, Thermotoga Maritima Glutamate Dehydrogenase ... 471 e-132
sp|P96110|DHE3_THEMA GLUTAMATE DEHYDROGENASE (GDH) >gi|7431776|p... 469 e-131
pir||T45284 glutamate dehydrogenase (NAD(P)+) (EC 1.4.1.3) [vali... 467 e-130
sp|P50735|GUDB_BACSU NAD-SPECIFIC GLUTAMATE DEHYDROGENASE (NAD-G... 436 e-121
dbj|BAB05341.1| (AP001512) glutamate dehydrogenase [Bacillus hal... 432 e-120
sp|P27346|DHE2_CLODI NAD-SPECIFIC GLUTAMATE DEHYDROGENASE (NAD-G... 418 e-116
sp|P39633|YWEB_BACSU HYPOTHETICAL 46.6 KD OXIDOREDUCTASE IN UNG-... 416 e-115
dbj|BAB07661.1| (AP001520) glutamate dehydrogenase [Bacillus hal... 415 e-115
sp|Q9YC65|DHE3_AERPE GLUTAMATE DEHYDROGENASE (GDH) >gi|7431771|p... 411 e-114
pir||S39730 hypothetical protein - Bacillus subtilis >gi|413999|... 410 e-113
pir||B81079 glutamate dehydrogenase, NAD-specific NMB1476 [impor... 404 e-111
sp|P54386|DHE4_SYNY3 NADP-SPECIFIC GLUTAMATE DEHYDROGENASE (NADP... 402 e-111
pir||B81864 probable glutamate dehydrogenase (EC 1.4.1.2) NMA168... 401 e-111
dbj|BAB06437.1| (AP001516) glutamate dehydrogenase [Bacillus hal... 398 e-110
sp|P28997|DHE2_PEPAS NAD-SPECIFIC GLUTAMATE DEHYDROGENASE (NAD-G... 378 e-104
sp|P29051|DHE4_HALSA NADP-SPECIFIC GLUTAMATE DEHYDROGENASE (NADP... 374 e-103
gb|AAG18779.1| (AE004982) glutamate dehydrogenase; GdhB [Halobac... 363 2e-99
pir||T16981 glutamate dehydrogenase (EC 1.4.1.2) - curled-leaved... 362 4e-99
gb|AAG19574.1| (AE005047) glutamate dehydrogenase; GdhA2 [Haloba... 360 2e-98
gb|AAA72385.1| (L19115) glutamate dehydrogenase [hyperthermophil... 357 2e-97
sp|P52596|DHE3_VITVI GLUTAMATE DEHYDROGENASE (GDH) >gi|1085815|p... 353 3e-96
pir||S71217 glutamate dehydrogenase (EC 1.4.1.-) 1 - Arabidopsis... 353 3e-96
gb|AAG19131.1| (AE005011) glutamate dehydrogenase; GdhA1 [Haloba... 350 2e-95
pir||T49883 glutamate dehydrogenase 2 - Arabidopsis thaliana >gi... 349 3e-95
gb|AAK42230.1| NAD specific glutamate dehydrogenase (gdhA-4) [Su... 346 3e-94
pir||T43790 probable glutamate dehydrogenase [imported] - Pyroba... 345 7e-94
gb|AAK42099.1| NAD specific glutamate dehydrogenase (gdhA-2) [Su... 344 1e-93
sp|P80053|DHE3_SULSO GLUTAMATE DEHYDROGENASE (GDH) >gi|478591|pi... 344 1e-93
emb|CAB94837.1| (AJ277950) NADH-glutamate dehydrogenase [Nicotia... 343 2e-93
pir||T16982 glutamate dehydrogenase (EC 1.4.1.-) B - curled-leav... 341 8e-93
gb|AAF00627.1|AC009540_4 (AC009540) putative glutamate dehydroge... 341 8e-93
pir||T04342 glutamate dehydrogenase (EC 1.4.1.2) - maize >gi|193... 341 1e-92
pir||T04341 glutamate dehydrogenase mutant - maize >gi|1931629|g... 338 7e-92
pir||T03294 glutamate dehydrogenase (EC 1.4.1.2) - maize >gi|695... 338 9e-92
emb|CAA09478.1| (AJ011096) glutamate dehydrogenase [Asparagus of... 337 2e-91
gb|AAK42126.1| NAD specific glutamate dehydrogenase (gdhA-3) [Su... 332 4e-90
pir||JC6317 glutamate dehydrogenase (EC 1.4.1.2) precursor - tom... 331 8e-90
gb|AAK41684.1| NAD specific glutamate dehydrogenase (gdhA-1) [Su... 325 5e-88
emb|CAA52168.1| (X73990) glutamate dehydrogenase (NADP+) [Sulfol... 317 1e-85
sp|P39475|DHE4_SULSH NADP-SPECIFIC GLUTAMATE DEHYDROGENASE (NADP... 317 1e-85
pir||G75452 probable glutamate dehydrogenase - Deinococcus radio... 294 9e-79
gi|6912392 Glutamate dehydrogenase-2 [Homo sapiens] >gi|1352260|... 277 1e-73
gi|11422617 Glutamate dehydrogenase-2 [Homo sapiens] >gi|4156204... 277 1e-73
gi|6980956 glutamate dehydrogenase [Rattus norvegicus] >gi|56198... 277 2e-73
sp|P10860|DHE3_RAT GLUTAMATE DEHYDROGENASE PRECURSOR (GDH) >gi|9... 277 2e-73
gi|6680027 glutamate dehydrogenase [Mus musculus] >gi|118542|sp|... 277 2e-73
gi|4885281 glutamate dehydrogenase 1 [Homo sapiens] >gi|118541|s... 276 3e-73
gi|11430406 glutamate dehydrogenase 1 [Homo sapiens] 274 1e-72
pdb|1CH6|A Chain A, Crystal Structure Of Bovine Liver Glutamate ... 270 3e-71
sp|P00366|DHE3_BOVIN GLUTAMATE DEHYDROGENASE (GDH) >gi|66082|pir... 259 5e-68
gb|AAG15493.1| (AF279460) glutamate dehydrogenase [Paramecium te... 258 9e-68
gb|AAF56124.1| (AE003742) CG4434 gene product [Drosophila melano... 257 1e-67
sp|P54385|DHE3_DROME GLUTAMATE DEHYDROGENASE PRECURSOR (GDH) >gi... 256 3e-67
pir||T28022 hypothetical protein ZK829.4 - Caenorhabditis elegan... 256 4e-67
gb|AAC19750.1| (AF000967) putative glutamate dehydrogenase [Haem... 254 2e-66
emb|CAA72173.1| (Y11314) glutamate dehydrogenase (NAD(P)+) [Dros... 253 3e-66
sp|P00368|DHE3_CHICK GLUTAMATE DEHYDROGENASE (GDH) >gi|66083|pir... 248 8e-65
gb|AAF56209.2| (AE003745) Gdh gene product [Drosophila melanogas... 248 1e-64
sp|Q53199|DHE3_RHISN PROBABLE GLUTAMATE DEHYDROGENASE (GDH) >gi|... 215 6e-55
sp|P24295|DHE2_CLOSY NAD-SPECIFIC GLUTAMATE DEHYDROGENASE (NAD-G... 209 4e-53
pdb|1BGV|A Chain A, Glutamate Dehydrogenase >gi|1942184|pdb|1HRD... 209 4e-53
gb|AAF15393.1|AF109176_1 (AF109176) NAD dependent glutamate dehy... 209 6e-53
pdb|1K89| K89l Mutant Of Glutamate Dehydrogenase 207 2e-52
emb|CAA41635.1| (X58831) glutamate dehydrogenase (NADP+) [Chlore... 206 3e-52
sp|P28998|DHE4_CHLSO NADP-SPECIFIC GLUTAMATE DEHYDROGENASE (NADP... 206 4e-52
pir||S32227 glutamate dehydrogenase (NADP+) (EC 1.4.1.4) - Coryn... 206 5e-52
pdb|1AUP| Glutamate Dehydrogenase 204 1e-51
dbj|BAB05820.1| (AP001514) NADP-specific glutamate dehydrogenase... 203 2e-51
sp|P95544|DHE4_PRERU NADP-SPECIFIC GLUTAMATE DEHYDROGENASE (NADP... 203 3e-51
gb|AAC63990.1| (AF056335) NADP-specific glutamate dehydrogenase ... 203 4e-51
sp|Q03578|DHE2_PORGI NAD-SPECIFIC GLUTAMATE DEHYDROGENASE (NAD-G... 202 7e-51
sp|P94316|DHE4_BACFR NADP-SPECIFIC GLUTAMATE DEHYDROGENASE (NADP... 201 9e-51
sp|P28724|DHE4_GIALA NADP-SPECIFIC GLUTAMATE DEHYDROGENASE (NADP... 198 8e-50
sp|P94598|DHE4_BACTN NADP-SPECIFIC GLUTAMATE DEHYDROGENASE (NADP... 195 7e-49
sp|P43793|DHE4_HAEIN NADP-SPECIFIC GLUTAMATE DEHYDROGENASE (NADP... 192 5e-48
gb|AAB40143.1| (U82241) NAD(P)H-dependent glutamate dehydrogenas... 191 1e-47
emb|CAB54142.1| (AJ010746) glutamate dehydrogenase [Antarctic ba... 191 1e-47
gb|AAG01158.1| (AF285427) NADP-specific glutamate dehydrogenase ... 191 1e-47
dbj|BAB04543.1| (AP001509) glutamate dehydrogenase [Bacillus hal... 191 1e-47
gb|AAC06213.1| (AF051892) putative glutamate dehydrogenase [Tryp... 190 2e-47
sp|P00369|DHE4_NEUCR NADP-SPECIFIC GLUTAMATE DEHYDROGENASE (NADP... 190 2e-47
prf||1003201A dehydrogenase,NADP specific Glu [Neurospora crassa] 190 2e-47
pir||S19250 glutamate dehydrogenase (NADP+) (EC 1.4.1.4) - Coryn... 190 2e-47
gb|AAG01159.1| (AF285428) NADP-specific glutamate dehydrogenase ... 189 4e-47
gb|AAC95390.1| (AF109684) NADP-dependent glutamate dehydrogenase... 189 5e-47
pir||H83072 glutamate dehydrogenase PA4588 [imported] - Pseudomo... 185 1e-45
emb|CAA75437.1| (Y15166) NADP-glutamate dehydrogenase [Pseudomon... 184 1e-45
emb|CAB82051.1| (AL161803) NADP-specific glutamate dehydrogenase... 183 2e-45
pir||T42429 probable glutamate dehydrogenase (NADP+) (EC 1.4.1.4... 183 4e-45
pir||T41492 probable glutamate dehydrogenase (NADP+) (EC 1.4.1.4... 183 4e-45
pir||A33504 glutamate dehydrogenase (NADP+) (EC 1.4.1.4) - Salmo... 182 9e-45
sp|P15111|DHE4_SALTY NADP-SPECIFIC GLUTAMATE DEHYDROGENASE (NADP... 182 9e-45
gb|AAC14692.1| (AF009365) glutamate dehydrogenase [Trypanosoma c... 180 3e-44
pir||B81825 glutamate dehydrogenase (NADP+) (EC 1.4.1.4) NMA1964... 179 5e-44
pir||E75362 glutamate dehydrogenase - Deinococcus radiodurans (s... 178 1e-43
pir||H81050 glutamate dehydrogenase, NADP-specific NMB1710 [impo... 178 1e-43
gb|AAG28788.1|AF309087_1 (AF309087) NADP glutamate dehydrogenase... 178 1e-43
gb|AAF98446.1| (AY005438) NADP-dependent glutamate dehydrogenase... 177 2e-43
gi|6319256 NADP-linked glutamate dehydrogenase; Gdh3p [Saccharom... 177 2e-43
sp|P14657|DHE4_UNKP NADP-SPECIFIC GLUTAMATE DEHYDROGENASE (NADP-... 176 3e-43
gb|AAF00006.1|AF056974_1 (AF056974) glutamate dehydrogenase [Pen... 173 3e-42
sp|P00370|DHE4_ECOLI NADP-SPECIFIC GLUTAMATE DEHYDROGENASE (NADP... 173 3e-42
gb|AAC14691.1| (AF009364) glutamate dehydrogenase [Trypanosoma c... 173 4e-42
gb|AAA23868.1| (K02499) glutamate dehydrogenase [Escherichia coli] 172 6e-42
gb|AAA34642.1| (M10590) glutamate dehydrogenase [Saccharomyces c... 171 1e-41
sp|P29507|DHE4_DEBOC NADP-SPECIFIC GLUTAMATE DEHYDROGENASE (NADP... 170 2e-41
gi|6324951 NADP-specific glutamate dehydrogenase; Gdh1p [Sacchar... 170 2e-41
gb|AAD11789.1| (AF098675) glutamate dehydrogenase [Plasmodium fa... 169 5e-41
emb|CAA73390.1| (Y12927) glutamate dehydrogenase (NADP+) [Plasmo... 169 7e-41
gb|AAB03898.1| (M11297) glutamate dehydrogenase [Saccharomyces c... 168 9e-41
sp|P54388|DHE4_LACBI NADP-SPECIFIC GLUTAMATE DEHYDROGENASE (NADP... 168 2e-40
gb|AAG12331.1|AF269241_1 (AF269241) glutamate dehydrogenase [Pla... 168 2e-40
sp|P18819|DHE4_EMENI NADP-SPECIFIC GLUTAMATE DEHYDROGENASE (NADP... 166 4e-40
pir||S04904 glutamate dehydrogenase (NADP+) (EC 1.4.1.4) - Emeri... 166 6e-40
sp|Q9ZKD8|DHE4_HELPJ NADP-SPECIFIC GLUTAMATE DEHYDROGENASE (NADP... 166 6e-40
sp|P54387|DHE4_AGABI NADP-SPECIFIC GLUTAMATE DEHYDROGENASE (NADP... 163 4e-39
sp|P55990|DHE4_HELPY NADP-SPECIFIC GLUTAMATE DEHYDROGENASE (NADP... 162 9e-39
gb|AAG29684.1|AC025294_6 (AC025294) NADP-specific glutatamate de... 150 3e-35
dbj|BAA83910.1| (AB024549) GDHA [Bacillus halodurans] 120 3e-26
sp|P23307|DHPH_BACSH PHENYLALANINE DEHYDROGENASE (PHEDH) >gi|212... 106 7e-22
emb|CAB66900.1| (AJ270942) glutamate deshydrogenase [Klebsiella ... 104 3e-21
gb|AAA25070.1| (M30538) glutamate dehydrogenase (gdhA) (EC 1.4.1... 85 2e-15
gb|AAD21520.1| (AF009232) glutamate dehydrogenase [Klebsiella pn... 80 4e-14
>sp|Q47950|DHE3_PYRAB GLUTAMATE DEHYDROGENASE (GDH) >gi|7431770|pir||D75176 glutamate
dehydrogenase (nad(p)+) PAB0391 - Pyrococcus abyssi
(strain Orsay) >gi|5458001|emb|CAB49491.1| (AJ248284)
Glutamate dehydrogenase (NAD(P)+) [Pyrococcus abyssi]
Length = 420
Score = 859 bits (2195), Expect = 0.0
Identities = 420/420 (100%), Positives = 420/420 (100%)
Query: 1 MVEQDPFEIAVKQLERAAQYMKISEEALEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQ 60
MVEQDPFEIAVKQLERAAQYMKISEEALEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQ
Sbjct: 1 MVEQDPFEIAVKQLERAAQYMKISEEALEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQ 60
Query: 61 YNWARGPTKGGIRWHPEETLSTVKALAAWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREK 120
YNWARGPTKGGIRWHPEETLSTVKALAAWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREK
Sbjct: 61 YNWARGPTKGGIRWHPEETLSTVKALAAWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREK 120
Query: 121 ERLARGYIRAIYDVISPYEDIPAPDVYTNPQIMAWMMDEYETIARRKTPAFGIITGKPLS 180
ERLARGYIRAIYDVISPYEDIPAPDVYTNPQIMAWMMDEYETIARRKTPAFGIITGKPLS
Sbjct: 121 ERLARGYIRAIYDVISPYEDIPAPDVYTNPQIMAWMMDEYETIARRKTPAFGIITGKPLS 180
Query: 181 IGGSLGRNEATARGASYTIREAAKVLGWDDLKGKTIAIQGYGNAGYYLAKIMSEDYGMKV 240
IGGSLGRNEATARGASYTIREAAKVLGWDDLKGKTIAIQGYGNAGYYLAKIMSEDYGMKV
Sbjct: 181 IGGSLGRNEATARGASYTIREAAKVLGWDDLKGKTIAIQGYGNAGYYLAKIMSEDYGMKV 240
Query: 241 VAVSDSKGGIYNPDGLNADEVLKWKREHGSVKDFPGATNITNEELLELEVDVLAPAAIEE 300
VAVSDSKGGIYNPDGLNADEVLKWKREHGSVKDFPGATNITNEELLELEVDVLAPAAIEE
Sbjct: 241 VAVSDSKGGIYNPDGLNADEVLKWKREHGSVKDFPGATNITNEELLELEVDVLAPAAIEE 300
Query: 301 VITKKNADNIKAKIVAEVANGPVTPEADEILFEKGILQIPDFLCNAGGVTVSYFEWVQNI 360
VITKKNADNIKAKIVAEVANGPVTPEADEILFEKGILQIPDFLCNAGGVTVSYFEWVQNI
Sbjct: 301 VITKKNADNIKAKIVAEVANGPVTPEADEILFEKGILQIPDFLCNAGGVTVSYFEWVQNI 360
Query: 361 TGYYWTLEEVREKLDKKMTKAFYDVYNTAKEKNIHMRDAAYVVAVQRVYQAMLDRGWVKH 420
TGYYWTLEEVREKLDKKMTKAFYDVYNTAKEKNIHMRDAAYVVAVQRVYQAMLDRGWVKH
Sbjct: 361 TGYYWTLEEVREKLDKKMTKAFYDVYNTAKEKNIHMRDAAYVVAVQRVYQAMLDRGWVKH 420
>pir||A71038 probable glutamate dehydrogenase - Pyrococcus horikoshii
>gi|3258022|dbj|BAA30705.1| (AP000006) 422aa long
hypothetical glutamate dehydrogenase [Pyrococcus
horikoshii]
Length = 422
Score = 850 bits (2171), Expect = 0.0
Identities = 413/420 (98%), Positives = 419/420 (99%)
Query: 1 MVEQDPFEIAVKQLERAAQYMKISEEALEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQ 60
MVEQDPFEIAVKQLERAAQ+MKISEEALEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQ
Sbjct: 3 MVEQDPFEIAVKQLERAAQHMKISEEALEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQ 62
Query: 61 YNWARGPTKGGIRWHPEETLSTVKALAAWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREK 120
YNWARGPTKGGIRWHPEETLSTVKALAAWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREK
Sbjct: 63 YNWARGPTKGGIRWHPEETLSTVKALAAWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREK 122
Query: 121 ERLARGYIRAIYDVISPYEDIPAPDVYTNPQIMAWMMDEYETIARRKTPAFGIITGKPLS 180
ERLARGYIRA+YD+ISPYEDIPAPDVYTNPQIMAWMMDEYETIARRKTPAFGIITGKPLS
Sbjct: 123 ERLARGYIRAVYDIISPYEDIPAPDVYTNPQIMAWMMDEYETIARRKTPAFGIITGKPLS 182
Query: 181 IGGSLGRNEATARGASYTIREAAKVLGWDDLKGKTIAIQGYGNAGYYLAKIMSEDYGMKV 240
IGGSLGRNEATARGASYTIREAAKVLGWD LKGKTIAIQGYGNAGYYLAKIMSEDYGMKV
Sbjct: 183 IGGSLGRNEATARGASYTIREAAKVLGWDGLKGKTIAIQGYGNAGYYLAKIMSEDYGMKV 242
Query: 241 VAVSDSKGGIYNPDGLNADEVLKWKREHGSVKDFPGATNITNEELLELEVDVLAPAAIEE 300
VAVSDSKGGIYNPDGLNADEVLKWKREHGSVKDFPGATNI+NEELLEL+VDVLAPAAIEE
Sbjct: 243 VAVSDSKGGIYNPDGLNADEVLKWKREHGSVKDFPGATNISNEELLELDVDVLAPAAIEE 302
Query: 301 VITKKNADNIKAKIVAEVANGPVTPEADEILFEKGILQIPDFLCNAGGVTVSYFEWVQNI 360
VITKKNADNIKAKIVAEVANGPVTPEADEILFEKGILQIPDFLCNAGGVTVSYFEWVQNI
Sbjct: 303 VITKKNADNIKAKIVAEVANGPVTPEADEILFEKGILQIPDFLCNAGGVTVSYFEWVQNI 362
Query: 361 TGYYWTLEEVREKLDKKMTKAFYDVYNTAKEKNIHMRDAAYVVAVQRVYQAMLDRGWVKH 420
TGYYWTLEEVRE+LDKKMTKAFYDVYNTAKEKNIHMRDAAYVVAVQRVYQAMLDRGWVKH
Sbjct: 363 TGYYWTLEEVRERLDKKMTKAFYDVYNTAKEKNIHMRDAAYVVAVQRVYQAMLDRGWVKH 422
>sp|O52310|DHE3_PYRHO GLUTAMATE DEHYDROGENASE (GDH) >gi|2828004|gb|AAB99956.1| (AF035935)
glutamate dehydrogenase [Pyrococcus horikoshii]
Length = 420
Score = 850 bits (2171), Expect = 0.0
Identities = 413/420 (98%), Positives = 419/420 (99%)
Query: 1 MVEQDPFEIAVKQLERAAQYMKISEEALEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQ 60
MVEQDPFEIAVKQLERAAQ+MKISEEALEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQ
Sbjct: 1 MVEQDPFEIAVKQLERAAQHMKISEEALEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQ 60
Query: 61 YNWARGPTKGGIRWHPEETLSTVKALAAWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREK 120
YNWARGPTKGGIRWHPEETLSTVKALAAWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREK
Sbjct: 61 YNWARGPTKGGIRWHPEETLSTVKALAAWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREK 120
Query: 121 ERLARGYIRAIYDVISPYEDIPAPDVYTNPQIMAWMMDEYETIARRKTPAFGIITGKPLS 180
ERLARGYIRA+YD+ISPYEDIPAPDVYTNPQIMAWMMDEYETIARRKTPAFGIITGKPLS
Sbjct: 121 ERLARGYIRAVYDIISPYEDIPAPDVYTNPQIMAWMMDEYETIARRKTPAFGIITGKPLS 180
Query: 181 IGGSLGRNEATARGASYTIREAAKVLGWDDLKGKTIAIQGYGNAGYYLAKIMSEDYGMKV 240
IGGSLGRNEATARGASYTIREAAKVLGWD LKGKTIAIQGYGNAGYYLAKIMSEDYGMKV
Sbjct: 181 IGGSLGRNEATARGASYTIREAAKVLGWDGLKGKTIAIQGYGNAGYYLAKIMSEDYGMKV 240
Query: 241 VAVSDSKGGIYNPDGLNADEVLKWKREHGSVKDFPGATNITNEELLELEVDVLAPAAIEE 300
VAVSDSKGGIYNPDGLNADEVLKWKREHGSVKDFPGATNI+NEELLEL+VDVLAPAAIEE
Sbjct: 241 VAVSDSKGGIYNPDGLNADEVLKWKREHGSVKDFPGATNISNEELLELDVDVLAPAAIEE 300
Query: 301 VITKKNADNIKAKIVAEVANGPVTPEADEILFEKGILQIPDFLCNAGGVTVSYFEWVQNI 360
VITKKNADNIKAKIVAEVANGPVTPEADEILFEKGILQIPDFLCNAGGVTVSYFEWVQNI
Sbjct: 301 VITKKNADNIKAKIVAEVANGPVTPEADEILFEKGILQIPDFLCNAGGVTVSYFEWVQNI 360
Query: 361 TGYYWTLEEVREKLDKKMTKAFYDVYNTAKEKNIHMRDAAYVVAVQRVYQAMLDRGWVKH 420
TGYYWTLEEVRE+LDKKMTKAFYDVYNTAKEKNIHMRDAAYVVAVQRVYQAMLDRGWVKH
Sbjct: 361 TGYYWTLEEVRERLDKKMTKAFYDVYNTAKEKNIHMRDAAYVVAVQRVYQAMLDRGWVKH 420
>sp|Q47951|DHE3_PYREN GLUTAMATE DEHYDROGENASE (GDH) >gi|464224|gb|AAA64795.1| (L12408)
glutamate dehydrogenase [Pyrococcus endeavori]
Length = 420
Score = 846 bits (2162), Expect = 0.0
Identities = 413/420 (98%), Positives = 416/420 (98%)
Query: 1 MVEQDPFEIAVKQLERAAQYMKISEEALEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQ 60
MVEQDPFEIAVKQLERAAQYMKISEEALEFLKRPQRIVEVTIPVEMDDG+VKVFTGFRVQ
Sbjct: 1 MVEQDPFEIAVKQLERAAQYMKISEEALEFLKRPQRIVEVTIPVEMDDGTVKVFTGFRVQ 60
Query: 61 YNWARGPTKGGIRWHPEETLSTVKALAAWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREK 120
YNWARGPTKGGIRWHPEETLSTVKALAAWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREK
Sbjct: 61 YNWARGPTKGGIRWHPEETLSTVKALAAWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREK 120
Query: 121 ERLARGYIRAIYDVISPYEDIPAPDVYTNPQIMAWMMDEYETIARRKTPAFGIITGKPLS 180
ERLARGYIRAIYDVISPYEDIPAPDVYTNPQIMAWMMDEYE I+RRKTPAFGIITGKPLS
Sbjct: 121 ERLARGYIRAIYDVISPYEDIPAPDVYTNPQIMAWMMDEYEAISRRKTPAFGIITGKPLS 180
Query: 181 IGGSLGRNEATARGASYTIREAAKVLGWDDLKGKTIAIQGYGNAGYYLAKIMSEDYGMKV 240
IGGSLGRNEATARGASYTIREA KVLGW DLKGKTIAIQGYGNAGYYLAKIMSEDYGMKV
Sbjct: 181 IGGSLGRNEATARGASYTIREARKVLGWGDLKGKTIAIQGYGNAGYYLAKIMSEDYGMKV 240
Query: 241 VAVSDSKGGIYNPDGLNADEVLKWKREHGSVKDFPGATNITNEELLELEVDVLAPAAIEE 300
VAVSDSKGGIYNPDGLNADEVLKWK+EHGSVKDFPGATNITNEELLELEVDVLAPAAIEE
Sbjct: 241 VAVSDSKGGIYNPDGLNADEVLKWKQEHGSVKDFPGATNITNEELLELEVDVLAPAAIEE 300
Query: 301 VITKKNADNIKAKIVAEVANGPVTPEADEILFEKGILQIPDFLCNAGGVTVSYFEWVQNI 360
VITKKNADNIKAKIVAEVANGPVTPEADEILFEKGILQIPDFLCNAGGVTVSYFEWVQNI
Sbjct: 301 VITKKNADNIKAKIVAEVANGPVTPEADEILFEKGILQIPDFLCNAGGVTVSYFEWVQNI 360
Query: 361 TGYYWTLEEVREKLDKKMTKAFYDVYNTAKEKNIHMRDAAYVVAVQRVYQAMLDRGWVKH 420
TGYYWTLEEVREKLDKKMTKAFYDVYNTAKEKNIHMRDA YVVAVQRVYQAMLDRGWVKH
Sbjct: 361 TGYYWTLEEVREKLDKKMTKAFYDVYNTAKEKNIHMRDADYVVAVQRVYQAMLDRGWVKH 420
>pir||A47410 glutamate dehydrogenase (NAD(P)+) (EC 1.4.1.3) - Pyrococcus
endeavori (strain ES4)
Length = 420
Score = 843 bits (2155), Expect = 0.0
Identities = 412/420 (98%), Positives = 415/420 (98%)
Query: 1 MVEQDPFEIAVKQLERAAQYMKISEEALEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQ 60
MVEQDPFEIAVKQLERAAQYMKISEEALEFLKRPQRIVEVTIPVEMDDG+VKVFTGFRVQ
Sbjct: 1 MVEQDPFEIAVKQLERAAQYMKISEEALEFLKRPQRIVEVTIPVEMDDGTVKVFTGFRVQ 60
Query: 61 YNWARGPTKGGIRWHPEETLSTVKALAAWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREK 120
YNWARGPTKGGIRWHPEETLSTVKALAAWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREK
Sbjct: 61 YNWARGPTKGGIRWHPEETLSTVKALAAWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREK 120
Query: 121 ERLARGYIRAIYDVISPYEDIPAPDVYTNPQIMAWMMDEYETIARRKTPAFGIITGKPLS 180
ERLARGYIRAIYDVISPYEDIPAP VYTNPQIMAWMMDEYE I+RRKTPAFGIITGKPLS
Sbjct: 121 ERLARGYIRAIYDVISPYEDIPAPHVYTNPQIMAWMMDEYEAISRRKTPAFGIITGKPLS 180
Query: 181 IGGSLGRNEATARGASYTIREAAKVLGWDDLKGKTIAIQGYGNAGYYLAKIMSEDYGMKV 240
IGGSLGRNEATARGASYTIREA KVLGW DLKGKTIAIQGYGNAGYYLAKIMSEDYGMKV
Sbjct: 181 IGGSLGRNEATARGASYTIREARKVLGWGDLKGKTIAIQGYGNAGYYLAKIMSEDYGMKV 240
Query: 241 VAVSDSKGGIYNPDGLNADEVLKWKREHGSVKDFPGATNITNEELLELEVDVLAPAAIEE 300
VAVSDSKGGIYNPDGLNADEVLKWK+EHGSVKDFPGATNITNEELLELEVDVLAPAAIEE
Sbjct: 241 VAVSDSKGGIYNPDGLNADEVLKWKQEHGSVKDFPGATNITNEELLELEVDVLAPAAIEE 300
Query: 301 VITKKNADNIKAKIVAEVANGPVTPEADEILFEKGILQIPDFLCNAGGVTVSYFEWVQNI 360
VITKKNADNIKAKIVAEVANGPVTPEADEILFEKGILQIPDFLCNAGGVTVSYFEWVQNI
Sbjct: 301 VITKKNADNIKAKIVAEVANGPVTPEADEILFEKGILQIPDFLCNAGGVTVSYFEWVQNI 360
Query: 361 TGYYWTLEEVREKLDKKMTKAFYDVYNTAKEKNIHMRDAAYVVAVQRVYQAMLDRGWVKH 420
TGYYWTLEEVREKLDKKMTKAFYDVYNTAKEKNIHMRDA YVVAVQRVYQAMLDRGWVKH
Sbjct: 361 TGYYWTLEEVREKLDKKMTKAFYDVYNTAKEKNIHMRDADYVVAVQRVYQAMLDRGWVKH 420
>sp|P80319|DHE3_PYRFU GLUTAMATE DEHYDROGENASE (GDH) >gi|11374956|pir||JN0854 glutamate
dehydrogenase (EC 1.4.1.2) - Pyrococcus furiosus
>gi|1122753|gb|AAA83390.1| (M97860) glutamate
dehydrogenase [Pyrococcus furiosus]
Length = 420
Score = 837 bits (2139), Expect = 0.0
Identities = 407/420 (96%), Positives = 415/420 (97%)
Query: 1 MVEQDPFEIAVKQLERAAQYMKISEEALEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQ 60
MVEQDP+EI +KQLERAAQYM+ISEEALEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQ
Sbjct: 1 MVEQDPYEIVIKQLERAAQYMEISEEALEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQ 60
Query: 61 YNWARGPTKGGIRWHPEETLSTVKALAAWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREK 120
+NWARGPTKGGIRWHPEETLSTVKALAAWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREK
Sbjct: 61 HNWARGPTKGGIRWHPEETLSTVKALAAWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREK 120
Query: 121 ERLARGYIRAIYDVISPYEDIPAPDVYTNPQIMAWMMDEYETIARRKTPAFGIITGKPLS 180
ERLARGYIRAIYDVISPYEDIPAPDVYTNPQIMAWMMDEYETI+RRKTPAFGIITGKPLS
Sbjct: 121 ERLARGYIRAIYDVISPYEDIPAPDVYTNPQIMAWMMDEYETISRRKTPAFGIITGKPLS 180
Query: 181 IGGSLGRNEATARGASYTIREAAKVLGWDDLKGKTIAIQGYGNAGYYLAKIMSEDYGMKV 240
IGGSLGR EATARGASYTIREAAKVLGWD LKGKTIAIQGYGNAGYYLAKIMSED+GMKV
Sbjct: 181 IGGSLGRIEATARGASYTIREAAKVLGWDTLKGKTIAIQGYGNAGYYLAKIMSEDFGMKV 240
Query: 241 VAVSDSKGGIYNPDGLNADEVLKWKREHGSVKDFPGATNITNEELLELEVDVLAPAAIEE 300
VAVSDSKGGIYNPDGLNADEVLKWK EHGSVKDFPGATNITNEELLELEVDVLAPAAIEE
Sbjct: 241 VAVSDSKGGIYNPDGLNADEVLKWKNEHGSVKDFPGATNITNEELLELEVDVLAPAAIEE 300
Query: 301 VITKKNADNIKAKIVAEVANGPVTPEADEILFEKGILQIPDFLCNAGGVTVSYFEWVQNI 360
VITKKNADNIKAKIVAEVANGPVTPEADEILFEKGILQIPDFLCNAGGVTVSYFEWVQNI
Sbjct: 301 VITKKNADNIKAKIVAEVANGPVTPEADEILFEKGILQIPDFLCNAGGVTVSYFEWVQNI 360
Query: 361 TGYYWTLEEVREKLDKKMTKAFYDVYNTAKEKNIHMRDAAYVVAVQRVYQAMLDRGWVKH 420
TGYYWT+EEVRE+LDKKMTKAFYDVYN AKEKNIHMRDAAYVVAVQRVYQAMLDRGWVKH
Sbjct: 361 TGYYWTIEEVRERLDKKMTKAFYDVYNIAKEKNIHMRDAAYVVAVQRVYQAMLDRGWVKH 420
>pdb|1GTM|A Chain A, Structure Of Glutamate Dehydrogenase
>gi|1942607|pdb|1GTM|B Chain B, Structure Of Glutamate
Dehydrogenase >gi|1942608|pdb|1GTM|C Chain C, Structure
Of Glutamate Dehydrogenase
Length = 419
Score = 833 bits (2128), Expect = 0.0
Identities = 405/419 (96%), Positives = 413/419 (97%)
Query: 2 VEQDPFEIAVKQLERAAQYMKISEEALEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQY 61
VE DP+EI +KQLERAAQYM+ISEEALEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQ+
Sbjct: 1 VEADPYEIVIKQLERAAQYMEISEEALEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQH 60
Query: 62 NWARGPTKGGIRWHPEETLSTVKALAAWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREKE 121
NWARGPTKGGIRWHPEETLSTVKALAAWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREKE
Sbjct: 61 NWARGPTKGGIRWHPEETLSTVKALAAWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREKE 120
Query: 122 RLARGYIRAIYDVISPYEDIPAPDVYTNPQIMAWMMDEYETIARRKTPAFGIITGKPLSI 181
RLARGYIRAIYDVISPYEDIPAPDVYTNPQIMAWMMDEYETI+RRKTPAFGIITGKPLSI
Sbjct: 121 RLARGYIRAIYDVISPYEDIPAPDVYTNPQIMAWMMDEYETISRRKTPAFGIITGKPLSI 180
Query: 182 GGSLGRNEATARGASYTIREAAKVLGWDDLKGKTIAIQGYGNAGYYLAKIMSEDYGMKVV 241
GGSLGR EATARGASYTIREAAKVLGWD LKGKTIAIQGYGNAGYYLAKIMSED+GMKVV
Sbjct: 181 GGSLGRIEATARGASYTIREAAKVLGWDTLKGKTIAIQGYGNAGYYLAKIMSEDFGMKVV 240
Query: 242 AVSDSKGGIYNPDGLNADEVLKWKREHGSVKDFPGATNITNEELLELEVDVLAPAAIEEV 301
AVSDSKGGIYNPDGLNADEVLKWK EHGSVKDFPGATNITNEELLELEVDVLAPAAIEEV
Sbjct: 241 AVSDSKGGIYNPDGLNADEVLKWKNEHGSVKDFPGATNITNEELLELEVDVLAPAAIEEV 300
Query: 302 ITKKNADNIKAKIVAEVANGPVTPEADEILFEKGILQIPDFLCNAGGVTVSYFEWVQNIT 361
ITKKNADNIKAKIVAEVANGPVTPEADEILFEKGILQIPDFLCNAGGVTVSYFEWVQNIT
Sbjct: 301 ITKKNADNIKAKIVAEVANGPVTPEADEILFEKGILQIPDFLCNAGGVTVSYFEWVQNIT 360
Query: 362 GYYWTLEEVREKLDKKMTKAFYDVYNTAKEKNIHMRDAAYVVAVQRVYQAMLDRGWVKH 420
GYYWT+EEVRE+LDKKMTKAFYDVYN AKEKNIHMRDAAYVVAVQRVYQAMLDRGWVKH
Sbjct: 361 GYYWTIEEVRERLDKKMTKAFYDVYNIAKEKNIHMRDAAYVVAVQRVYQAMLDRGWVKH 419
>sp|Q56304|DHE3_THELI GLUTAMATE DEHYDROGENASE (GDH) >gi|310891|gb|AAA72393.1| (L19995)
glutamate dehydrogenase [Thermococcus litoralis]
Length = 419
Score = 769 bits (1965), Expect = 0.0
Identities = 373/419 (89%), Positives = 398/419 (94%), Gaps = 1/419 (0%)
Query: 1 MVEQDPFEIAVKQLERAAQYMKISEEALEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQ 60
MVEQDPFEIAVKQLERAAQYM ISEEALEFLKRPQRIVEV+IPVEMDDGSVKVFTGFRVQ
Sbjct: 1 MVEQDPFEIAVKQLERAAQYMDISEEALEFLKRPQRIVEVSIPVEMDDGSVKVFTGFRVQ 60
Query: 61 YNWARGPTKGGIRWHPEETLSTVKALAAWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREK 120
YNWARGPTKGGIRWHPEETLSTVKALAAWMTWKTAVMDLPYGGGKGG+I +PK++SDREK
Sbjct: 61 YNWARGPTKGGIRWHPEETLSTVKALAAWMTWKTAVMDLPYGGGKGGVICNPKEMSDREK 120
Query: 121 ERLARGYIRAIYDVISPYEDIPAPDVYTNPQIMAWMMDEYETIARRKTPAFGIITGKPLS 180
ERLARGY+RAIYDVISPY DIPAPDVYTNPQIMAWMMDEYETI+RRK P+FG+ITGKP S
Sbjct: 121 ERLARGYVRAIYDVISPYTDIPAPDVYTNPQIMAWMMDEYETISRRKDPSFGVITGKPPS 180
Query: 181 IGGSLGRNEATARGASYTIREAAKVLGWDDLKGKTIAIQGYGNAGYYLAKIMSEDYGMKV 240
+GG + R +ATARGASYT+REAAK LG DLKGKTIAIQGYGNAGYY+AKIMSE+YGMKV
Sbjct: 181 VGGIVARMDATARGASYTVREAAKALGM-DLKGKTIAIQGYGNAGYYMAKIMSEEYGMKV 239
Query: 241 VAVSDSKGGIYNPDGLNADEVLKWKREHGSVKDFPGATNITNEELLELEVDVLAPAAIEE 300
VAVSD+KGGIYNPDGLNADEVL WK++ GSVKDFPGATNITNEELLELEVDVLAP+AIEE
Sbjct: 240 VAVSDTKGGIYNPDGLNADEVLAWKKKTGSVKDFPGATNITNEELLELEVDVLAPSAIEE 299
Query: 301 VITKKNADNIKAKIVAEVANGPVTPEADEILFEKGILQIPDFLCNAGGVTVSYFEWVQNI 360
VITKKNADNIKAKIVAE+ANGP TPEADEIL+EKGIL IPDFLCNAGGVTVSYFEWVQNI
Sbjct: 300 VITKKNADNIKAKIVAELANGPTTPEADEILYEKGILIIPDFLCNAGGVTVSYFEWVQNI 359
Query: 361 TGYYWTLEEVREKLDKKMTKAFYDVYNTAKEKNIHMRDAAYVVAVQRVYQAMLDRGWVK 419
TG YWT+EE R KLDKKMTKAF+DVYNT KEKNI+MRDAAYVVAV RVYQAM DRGW+K
Sbjct: 360 TGDYWTVEETRAKLDKKMTKAFWDVYNTHKEKNINMRDAAYVVAVSRVYQAMKDRGWIK 418
>pdb|1BVU|A Chain A, Glutamate Dehydrogenase From Thermococcus Litoralis
>gi|6137476|pdb|1BVU|B Chain B, Glutamate Dehydrogenase
From Thermococcus Litoralis >gi|6137477|pdb|1BVU|C Chain
C, Glutamate Dehydrogenase From Thermococcus Litoralis
>gi|6137478|pdb|1BVU|D Chain D, Glutamate Dehydrogenase
From Thermococcus Litoralis >gi|6137479|pdb|1BVU|E Chain
E, Glutamate Dehydrogenase From Thermococcus Litoralis
>gi|6137480|pdb|1BVU|F Chain F, Glutamate Dehydrogenase
From Thermococcus Litoralis
Length = 418
Score = 767 bits (1960), Expect = 0.0
Identities = 372/418 (88%), Positives = 397/418 (93%), Gaps = 1/418 (0%)
Query: 2 VEQDPFEIAVKQLERAAQYMKISEEALEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQY 61
VEQDPFEIAVKQLERAAQYM ISEEALEFLKRPQRIVEV+IPVEMDDGSVKVFTGFRVQY
Sbjct: 1 VEQDPFEIAVKQLERAAQYMDISEEALEFLKRPQRIVEVSIPVEMDDGSVKVFTGFRVQY 60
Query: 62 NWARGPTKGGIRWHPEETLSTVKALAAWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREKE 121
NWARGPTKGGIRWHPEETLSTVKALAAWMTWKTAVMDLPYGGGKGG+I +PK++SDREKE
Sbjct: 61 NWARGPTKGGIRWHPEETLSTVKALAAWMTWKTAVMDLPYGGGKGGVICNPKEMSDREKE 120
Query: 122 RLARGYIRAIYDVISPYEDIPAPDVYTNPQIMAWMMDEYETIARRKTPAFGIITGKPLSI 181
RLARGY+RAIYDVISPY DIPAPDVYTNPQIMAWMMDEYETI+RRK P+FG+ITGKP S+
Sbjct: 121 RLARGYVRAIYDVISPYTDIPAPDVYTNPQIMAWMMDEYETISRRKDPSFGVITGKPPSV 180
Query: 182 GGSLGRNEATARGASYTIREAAKVLGWDDLKGKTIAIQGYGNAGYYLAKIMSEDYGMKVV 241
GG + R +ATARGASYT+REAAK LG DLKGKTIAIQGYGNAGYY+AKIMSE+YGMKVV
Sbjct: 181 GGIVARMDATARGASYTVREAAKALGM-DLKGKTIAIQGYGNAGYYMAKIMSEEYGMKVV 239
Query: 242 AVSDSKGGIYNPDGLNADEVLKWKREHGSVKDFPGATNITNEELLELEVDVLAPAAIEEV 301
AVSD+KGGIYNPDGLNADEVL WK++ GSVKDFPGATNITNEELLELEVDVLAP+AIEEV
Sbjct: 240 AVSDTKGGIYNPDGLNADEVLAWKKKTGSVKDFPGATNITNEELLELEVDVLAPSAIEEV 299
Query: 302 ITKKNADNIKAKIVAEVANGPVTPEADEILFEKGILQIPDFLCNAGGVTVSYFEWVQNIT 361
ITKKNADNIKAKIVAE+ANGP TPEADEIL+EKGIL IPDFLCNAGGVTVSYFEWVQNIT
Sbjct: 300 ITKKNADNIKAKIVAELANGPTTPEADEILYEKGILIIPDFLCNAGGVTVSYFEWVQNIT 359
Query: 362 GYYWTLEEVREKLDKKMTKAFYDVYNTAKEKNIHMRDAAYVVAVQRVYQAMLDRGWVK 419
G YWT+EE R KLDKKMTKAF+DVYNT KEKNI+MRDAAYVVAV RVYQAM DRGW+K
Sbjct: 360 GDYWTVEETRAKLDKKMTKAFWDVYNTHKEKNINMRDAAYVVAVSRVYQAMKDRGWIK 417
>sp|O74024|DHE3_THEPR GLUTAMATE DEHYDROGENASE (GDH) >gi|11252782|pir||T44308 glutamate
dehydrogenase (EC 1.4.1.2) [imported] - Thermococcus
profundus >gi|3242405|dbj|BAA28943.1| (D87814) glutamate
dehydrogenase [Thermococcus profundus]
Length = 419
Score = 741 bits (1891), Expect = 0.0
Identities = 360/419 (85%), Positives = 387/419 (91%), Gaps = 1/419 (0%)
Query: 1 MVEQDPFEIAVKQLERAAQYMKISEEALEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQ 60
MVE DPFE+AVKQLERAAQYM ISEEALE+LK+P RIVEV++P+EMDDGSVKVFTGFRVQ
Sbjct: 1 MVEIDPFEMAVKQLERAAQYMDISEEALEWLKKPMRIVEVSVPIEMDDGSVKVFTGFRVQ 60
Query: 61 YNWARGPTKGGIRWHPEETLSTVKALAAWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREK 120
+NWARGPTKGGIRWHP ETLSTVKALA WMTWK AV+DLPYGGGKGGIIV+PK+LS+RE+
Sbjct: 61 HNWARGPTKGGIRWHPAETLSTVKALATWMTWKVAVVDLPYGGGKGGIIVNPKELSEREQ 120
Query: 121 ERLARGYIRAIYDVISPYEDIPAPDVYTNPQIMAWMMDEYETIARRKTPAFGIITGKPLS 180
ERLAR YIRA+YDVI P+ DIPAPDVYTNP+IM WMMDEYETI RRK PAFG+ITGKPLS
Sbjct: 121 ERLARAYIRAVYDVIGPWTDIPAPDVYTNPKIMGWMMDEYETIMRRKGPAFGVITGKPLS 180
Query: 181 IGGSLGRNEATARGASYTIREAAKVLGWDDLKGKTIAIQGYGNAGYYLAKIMSEDYGMKV 240
IGGSLGR ATA+GA +TIREAAK LG D LKGK IA+QGYGNAGYY AK+ E GM V
Sbjct: 181 IGGSLGRGTATAQGAIFTIREAAKALGID-LKGKKIAVQGYGNAGYYTAKLAKEQLGMTV 239
Query: 241 VAVSDSKGGIYNPDGLNADEVLKWKREHGSVKDFPGATNITNEELLELEVDVLAPAAIEE 300
VAVSDS+GGIYNPDGL+ DEVLKWKREHGSVKDFPGATNITNEELLELEVDVLAPAAIEE
Sbjct: 240 VAVSDSRGGIYNPDGLDPDEVLKWKREHGSVKDFPGATNITNEELLELEVDVLAPAAIEE 299
Query: 301 VITKKNADNIKAKIVAEVANGPVTPEADEILFEKGILQIPDFLCNAGGVTVSYFEWVQNI 360
VIT+KNADNIKAKIVAEVANGPVTPEAD+IL EKGILQIPDFLCNAGGVTVSYFEWVQNI
Sbjct: 300 VITEKNADNIKAKIVAEVANGPVTPEADDILREKGILQIPDFLCNAGGVTVSYFEWVQNI 359
Query: 361 TGYYWTLEEVREKLDKKMTKAFYDVYNTAKEKNIHMRDAAYVVAVQRVYQAMLDRGWVK 419
GYYWT EEVREKLDKKMTKAF++VYNT K+KNIHMRDAAYVVAV RVYQAM DRGWVK
Sbjct: 360 NGYYWTEEEVREKLDKKMTKAFWEVYNTHKDKNIHMRDAAYVVAVSRVYQAMKDRGWVK 418
>sp|O59650|DHE3_PYRKO GLUTAMATE DEHYDROGENASE (GDH) >gi|11252762|pir||T44789 glutamate
dehydrogenase (EC 1.4.1.2) [validated] - Pyrococcus sp
>gi|2982669|dbj|BAA25261.1| (D89911) glutamate
dehydrogenase [Pyrococcus sp.]
Length = 421
Score = 735 bits (1878), Expect = 0.0
Identities = 354/420 (84%), Positives = 386/420 (91%), Gaps = 1/420 (0%)
Query: 1 MVEQDPFEIAVKQLERAAQYMKISEEALEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQ 60
MVE DPFE+AV+QLERAAQ+M ISEEALE+LKRP RIVEV++PVEMDDGSVKVFTGFRVQ
Sbjct: 1 MVEIDPFEMAVQQLERAAQFMDISEEALEWLKRPMRIVEVSVPVEMDDGSVKVFTGFRVQ 60
Query: 61 YNWARGPTKGGIRWHPEETLSTVKALAAWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREK 120
+NWARGPTKGGIRWHP ETLSTVKALA WMTWK AV+DLPYGGGKGGIIVDPKKLS+RE+
Sbjct: 61 HNWARGPTKGGIRWHPAETLSTVKALATWMTWKVAVVDLPYGGGKGGIIVDPKKLSEREQ 120
Query: 121 ERLARGYIRAIYDVISPYEDIPAPDVYTNPQIMAWMMDEYETIARRKTPAFGIITGKPLS 180
ERLAR YIRA+YDVI P DIPAPDVYTNP+IMAWMMDEYETI RRK PAFG+ITGKP
Sbjct: 121 ERLARSYIRAVYDVIGPCTDIPAPDVYTNPKIMAWMMDEYETIMRRKGPAFGVITGKPPG 180
Query: 181 IGGSLGRNEATARGASYTIREAAKVLGWDDLKGKTIAIQGYGNAGYYLAKIMSEDYGMKV 240
+GG + R +ATARGA++TIREAAK LGWDDLKGKTIAIQGYGNAGYYL KIMSE++GMKV
Sbjct: 181 VGGIVARMDATARGAAFTIREAAKALGWDDLKGKTIAIQGYGNAGYYLHKIMSEEFGMKV 240
Query: 241 VAVSDSKGGIYNPDGL-NADEVLKWKREHGSVKDFPGATNITNEELLELEVDVLAPAAIE 299
VAVSDSKGGIYNPDGL ADEVLKWK+EHGSVKD PG NITNEELLELEVD+LAP+AIE
Sbjct: 241 VAVSDSKGGIYNPDGLPPADEVLKWKKEHGSVKDMPGTQNITNEELLELEVDILAPSAIE 300
Query: 300 EVITKKNADNIKAKIVAEVANGPVTPEADEILFEKGILQIPDFLCNAGGVTVSYFEWVQN 359
VITK+NADN+KAKIVAEVANGPVTPEADEIL EKGILQIPDFLCN GGVTVSYFEWVQN
Sbjct: 301 GVITKENADNVKAKIVAEVANGPVTPEADEILHEKGILQIPDFLCNTGGVTVSYFEWVQN 360
Query: 360 ITGYYWTLEEVREKLDKKMTKAFYDVYNTAKEKNIHMRDAAYVVAVQRVYQAMLDRGWVK 419
I G+YWT+EE R++LD KMTKAF+DV+NT KEKNIHMRDAAYVVAV RVY+AM RGWVK
Sbjct: 361 INGFYWTVEETRKRLDDKMTKAFWDVFNTHKEKNIHMRDAAYVVAVSRVYEAMKHRGWVK 420
>emb|CAC11907.1| (AL445065) probable glutamate dehydrogenase [Thermoplasma
acidophilum]
Length = 419
Score = 531 bits (1353), Expect = e-150
Identities = 258/412 (62%), Positives = 326/412 (78%), Gaps = 3/412 (0%)
Query: 5 DPFEIAVKQLERAAQYMKISEEALEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQYNWA 64
DPFE+A++QLE+AA +K+ E+ALE LK+P++I++V+IPV MD+G +KVFTGFRV+YN A
Sbjct: 9 DPFEMALQQLEKAAAVLKLDEQALEILKQPEKILQVSIPVRMDNGRIKVFTGFRVRYNTA 68
Query: 65 RGPTKGGIRWHPEETLSTVKALAAWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREKERLA 124
RGP KGGIR+H EETLSTVKALAAWMTWK A++D+P+GG KGG+I DPK +S E ERL+
Sbjct: 69 RGPGKGGIRYHTEETLSTVKALAAWMTWKCAIVDIPFGGAKGGVICDPKSMSQGELERLS 128
Query: 125 RGYIRAIYDVISPYEDIPAPDVYTNPQIMAWMMDEYETIARRKTPAFGIITGKPLSIGGS 184
RGYIRAI D I P D+PAPDVYTNPQIMAWMMDEYE + R P +ITGKPL +GGS
Sbjct: 129 RGYIRAIADFIGPEVDVPAPDVYTNPQIMAWMMDEYENVVRHSAP--NVITGKPLEVGGS 186
Query: 185 LGRNEATARGASYTIREAAKVLGWDDLKGKTIAIQGYGNAGYYLAKIMSEDYGMKVVAVS 244
GR +ATA+G Y +RE AK +G D K + +A+QG+GNAG + K + E +G KVVAVS
Sbjct: 187 EGRGDATAKGGMYVLREGAKRIGLDLSKAR-VAVQGFGNAGQFAVKFVHEMFGSKVVAVS 245
Query: 245 DSKGGIYNPDGLNADEVLKWKREHGSVKDFPGATNITNEELLELEVDVLAPAAIEEVITK 304
D+KGGIY DG++ +L+ K++ GSV FPG+ ITNEELLE +VDVL PAAIEE IT
Sbjct: 246 DTKGGIYVKDGIDYAALLEHKKKTGSVVGFPGSEPITNEELLESDVDVLIPAAIEEQITG 305
Query: 305 KNADNIKAKIVAEVANGPVTPEADEILFEKGILQIPDFLCNAGGVTVSYFEWVQNITGYY 364
KNAD I+AKIV E+ANGP TPEADEIL+++GIL +PDFL N+GGVTVSYFEWVQN G Y
Sbjct: 306 KNADRIRAKIVLELANGPTTPEADEILYKRGILDLPDFLSNSGGVTVSYFEWVQNNYGEY 365
Query: 365 WTLEEVREKLDKKMTKAFYDVYNTAKEKNIHMRDAAYVVAVQRVYQAMLDRG 416
WT ++V +KLD+KMTKA +DV++ + ++ R AAYVV+V++V AM RG
Sbjct: 366 WTADDVYKKLDQKMTKAAHDVFDAMDKYKVNPRTAAYVVSVKKVADAMKARG 417
>emb|CAC11774.1| (AL445064) probable glutamate dehydrogenase [Thermoplasma
acidophilum]
Length = 436
Score = 515 bits (1313), Expect = e-145
Identities = 252/416 (60%), Positives = 314/416 (74%), Gaps = 3/416 (0%)
Query: 2 VEQDPFEIAVKQLERAAQYMKISEEALEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQY 61
VE+DPFEIA+KQL +AA+ + + E+ALE L PQ+I++V++PV+MDDG VKVFTGFRV++
Sbjct: 23 VEEDPFEIALKQLRKAAKVLNLDEQALEILSSPQKILQVSLPVKMDDGKVKVFTGFRVRH 82
Query: 62 NWARGPTKGGIRWHPEETLSTVKALAAWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREKE 121
N ARGP KGGIR+HP+ETLSTVKAL+ WMTWK A+ D+PYGG KGGII DP +S E E
Sbjct: 83 NIARGPAKGGIRFHPQETLSTVKALSMWMTWKCAIADIPYGGAKGGIICDPSTMSQGELE 142
Query: 122 RLARGYIRAIYDVISPYEDIPAPDVYTNPQIMAWMMDEYETIARRKTPAFGIITGKPLSI 181
RL+R YIRAI D I P D+PAPDV TNPQIMAWM+DEYE I R P +ITGKPL +
Sbjct: 143 RLSRAYIRAIADFIGPDVDVPAPDVNTNPQIMAWMLDEYENIVRHNAP--NVITGKPLEV 200
Query: 182 GGSLGRNEATARGASYTIREAAKVLGWDDLKGKTIAIQGYGNAGYYLAKIMSEDYGMKVV 241
GGSLGR ++T +G + +RE AK +G D K + +A+QG+GN G + K + E +G KVV
Sbjct: 201 GGSLGRFDSTGKGGMFVLREGAKKIGLDLSKAR-VAVQGFGNVGQFAVKFVEEMFGAKVV 259
Query: 242 AVSDSKGGIYNPDGLNADEVLKWKREHGSVKDFPGATNITNEELLELEVDVLAPAAIEEV 301
AVSD KGGIY+ +G D++L W ++ GSV FPG+ ITNEELLE +VDVL PAAIEE
Sbjct: 260 AVSDIKGGIYSENGFKFDDLLAWSKKIGSVVGFPGSKPITNEELLESDVDVLIPAAIEEQ 319
Query: 302 ITKKNADNIKAKIVAEVANGPVTPEADEILFEKGILQIPDFLCNAGGVTVSYFEWVQNIT 361
IT +NAD IKAKI+ E+ANGP TPEADEIL++KG L +PD L N+GGV VSYFEWVQN
Sbjct: 320 ITARNADKIKAKIILELANGPTTPEADEILYKKGKLVLPDVLSNSGGVIVSYFEWVQNNY 379
Query: 362 GYYWTLEEVREKLDKKMTKAFYDVYNTAKEKNIHMRDAAYVVAVQRVYQAMLDRGW 417
G YW+ EEV KLD K+TKA V T + ++ R AAYV+AV++V AM RGW
Sbjct: 380 GEYWSTEEVTNKLDVKITKAARQVLETMDKYHVDPRTAAYVIAVKKVADAMKVRGW 435
>gb|AAA64796.1| (L19116) glutamate dehydrogenase [Pyrococcus abyssi]
Length = 234
Score = 483 bits (1231), Expect = e-135
Identities = 234/234 (100%), Positives = 234/234 (100%)
Query: 22 KISEEALEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQYNWARGPTKGGIRWHPEETLS 81
KISEEALEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQYNWARGPTKGGIRWHPEETLS
Sbjct: 1 KISEEALEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQYNWARGPTKGGIRWHPEETLS 60
Query: 82 TVKALAAWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREKERLARGYIRAIYDVISPYEDI 141
TVKALAAWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREKERLARGYIRAIYDVISPYEDI
Sbjct: 61 TVKALAAWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREKERLARGYIRAIYDVISPYEDI 120
Query: 142 PAPDVYTNPQIMAWMMDEYETIARRKTPAFGIITGKPLSIGGSLGRNEATARGASYTIRE 201
PAPDVYTNPQIMAWMMDEYETIARRKTPAFGIITGKPLSIGGSLGRNEATARGASYTIRE
Sbjct: 121 PAPDVYTNPQIMAWMMDEYETIARRKTPAFGIITGKPLSIGGSLGRNEATARGASYTIRE 180
Query: 202 AAKVLGWDDLKGKTIAIQGYGNAGYYLAKIMSEDYGMKVVAVSDSKGGIYNPDG 255
AAKVLGWDDLKGKTIAIQGYGNAGYYLAKIMSEDYGMKVVAVSDSKGGIYNPDG
Sbjct: 181 AAKVLGWDDLKGKTIAIQGYGNAGYYLAKIMSEDYGMKVVAVSDSKGGIYNPDG 234
>pdb|2TMG|A Chain A, Thermotoga Maritima Glutamate Dehydrogenase Mutant S128r,
T158e, N117r, S160e >gi|6730588|pdb|2TMG|B Chain B,
Thermotoga Maritima Glutamate Dehydrogenase Mutant
S128r, T158e, N117r, S160e >gi|6730589|pdb|2TMG|C Chain
C, Thermotoga Maritima Glutamate Dehydrogenase Mutant
S128r, T158e, N117r, S160e >gi|6730590|pdb|2TMG|D Chain
D, Thermotoga Maritima Glutamate Dehydrogenase Mutant
S128r, T158e, N117r, S160e >gi|6730591|pdb|2TMG|E Chain
E, Thermotoga Maritima Glutamate Dehydrogenase Mutant
S128r, T158e, N117r, S160e >gi|6730592|pdb|2TMG|F Chain
F, Thermotoga Maritima Glutamate Dehydrogenase Mutant
S128r, T158e, N117r, S160e
Length = 415
Score = 474 bits (1208), Expect = e-133
Identities = 233/414 (56%), Positives = 297/414 (71%), Gaps = 3/414 (0%)
Query: 3 EQDPFEIAVKQLERAAQYMKISEEALEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQYN 62
E+ +E+AV+Q RAA M + + E L+RP+R++ V PV MDDG V+VFTG+RVQ+N
Sbjct: 2 EKSLYEMAVEQFNRAASLMDLESDLAEVLRRPKRVLIVEFPVRMDDGHVEVFTGYRVQHN 61
Query: 63 WARGPTKGGIRWHPEETLSTVKALAAWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREKER 122
ARGP KGGIR+HP+ TL VKALA WMTWKTAVM+LP+GGGKGG+ VDPKKLS RE ER
Sbjct: 62 VARGPAKGGIRYHPDVTLDEVKALAFWMTWKTAVMNLPFGGGKGGVRVDPKKLSRRELER 121
Query: 123 LARGYIRAIYDVISPYEDIPAPDVYTNPQIMAWMMDEYETIARRKTPAFGIITGKPLSIG 182
L+R + R I +I PY DIPAPDV TN ++AW MDEYE GI+TGKP+ +G
Sbjct: 122 LSRRFFREIQVIIGPYNDIPAPDVNTNADVIAWYMDEYEMNVGHTV--LGIVTGKPVELG 179
Query: 183 GSLGRNEATARGASYTIREAAKVLGWDDLKGKTIAIQGYGNAGYYLAKIMSEDYGMKVVA 242
GS GR EAT RG A VLG D K T+A+QG+GN G + A ++S++ G KVVA
Sbjct: 180 GSKGREEATGRGVKVCAGLAMDVLGIDPKKA-TVAVQGFGNVGQFAALLISQELGSKVVA 238
Query: 243 VSDSKGGIYNPDGLNADEVLKWKREHGSVKDFPGATNITNEELLELEVDVLAPAAIEEVI 302
VSDS+GGIYNP+G + +E++++K+EHG+V +P ITNEELLEL+VD+L PAA+E I
Sbjct: 239 VSDSRGGIYNPEGFDVEELIRYKKEHGTVVTYPKGERITNEELLELDVDILVPAALEGAI 298
Query: 303 TKKNADNIKAKIVAEVANGPVTPEADEILFEKGILQIPDFLCNAGGVTVSYFEWVQNITG 362
NA+ IKAK V E ANGP TPEADEIL +GIL +PD L NAGGVTVSYFEWVQ++
Sbjct: 299 HAGNAERIKAKAVVEGANGPTTPEADEILSRRGILVVPDILANAGGVTVSYFEWVQDLQS 358
Query: 363 YYWTLEEVREKLDKKMTKAFYDVYNTAKEKNIHMRDAAYVVAVQRVYQAMLDRG 416
++W L++VR L+K M AF DV ++ N+ MR AAY++A+ RV A RG
Sbjct: 359 FFWDLDQVRNALEKMMKGAFNDVMKVKEKYNVDMRTAAYILAIDRVAYATKKRG 412
>pdb|1B3B|A Chain A, Thermotoga Maritima Glutamate Dehydrogenase Mutant N97d,
G376k >gi|6730086|pdb|1B3B|B Chain B, Thermotoga
Maritima Glutamate Dehydrogenase Mutant N97d, G376k
>gi|6730087|pdb|1B3B|C Chain C, Thermotoga Maritima
Glutamate Dehydrogenase Mutant N97d, G376k
>gi|6730088|pdb|1B3B|D Chain D, Thermotoga Maritima
Glutamate Dehydrogenase Mutant N97d, G376k
>gi|6730089|pdb|1B3B|E Chain E, Thermotoga Maritima
Glutamate Dehydrogenase Mutant N97d, G376k
>gi|6730090|pdb|1B3B|F Chain F, Thermotoga Maritima
Glutamate Dehydrogenase Mutant N97d, G376k
Length = 415
Score = 471 bits (1198), Expect = e-132
Identities = 231/414 (55%), Positives = 294/414 (70%), Gaps = 3/414 (0%)
Query: 3 EQDPFEIAVKQLERAAQYMKISEEALEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQYN 62
E+ +E+AV+Q RAA M + + E L+RP+R++ V PV MDDG V+VFTG+RVQ+N
Sbjct: 2 EKSLYEMAVEQFNRAASLMDLESDLAEVLRRPKRVLIVEFPVRMDDGHVEVFTGYRVQHN 61
Query: 63 WARGPTKGGIRWHPEETLSTVKALAAWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREKER 122
ARGP KGGIR+HP+ TL VKALA WMTWKTAVMDLP+GGGKGG+ VDPKKLS E ER
Sbjct: 62 VARGPAKGGIRYHPDVTLDEVKALAFWMTWKTAVMDLPFGGGKGGVRVDPKKLSRNELER 121
Query: 123 LARGYIRAIYDVISPYEDIPAPDVYTNPQIMAWMMDEYETIARRKTPAFGIITGKPLSIG 182
L+R + I +I PY DIPAPDV TN ++AW MD Y GI+TGKP+ +G
Sbjct: 122 LSRRFFSEIQVIIGPYNDIPAPDVNTNADVIAWYMDTYSMNVGHTV--LGIVTGKPVELG 179
Query: 183 GSLGRNEATARGASYTIREAAKVLGWDDLKGKTIAIQGYGNAGYYLAKIMSEDYGMKVVA 242
GS GR EAT RG A VLG D K T+A+QG+GN G + A ++S++ G KVVA
Sbjct: 180 GSKGREEATGRGVKVCAGLAMDVLGIDPKKA-TVAVQGFGNVGQFAALLISQELGSKVVA 238
Query: 243 VSDSKGGIYNPDGLNADEVLKWKREHGSVKDFPGATNITNEELLELEVDVLAPAAIEEVI 302
VSDS+GGIYNP+G + +E++++K+EHG+V +P ITNEELLEL+VD+L PAA+E I
Sbjct: 239 VSDSRGGIYNPEGFDVEELIRYKKEHGTVVTYPKGERITNEELLELDVDILVPAALEGAI 298
Query: 303 TKKNADNIKAKIVAEVANGPVTPEADEILFEKGILQIPDFLCNAGGVTVSYFEWVQNITG 362
NA+ IKAK V E ANGP TPEADEIL +GIL +PD L NAGGVTVSYFEWVQ++
Sbjct: 299 HAGNAERIKAKAVVEGANGPTTPEADEILSRRGILVVPDILANAGGVTVSYFEWVQDLQS 358
Query: 363 YYWTLEEVREKLDKKMTKAFYDVYNTAKEKNIHMRDAAYVVAVQRVYQAMLDRG 416
++W L++VR L+K M KAF DV ++ N+ MR AAY++A+ RV A RG
Sbjct: 359 FFWDLDQVRNALEKMMKKAFNDVMKVKEKYNVDMRTAAYILAIDRVAYATKKRG 412
>sp|P96110|DHE3_THEMA GLUTAMATE DEHYDROGENASE (GDH) >gi|7431776|pir||G72305 glutamate
dehydrogenase - Thermotoga maritima (strain MSB8)
>gi|4981555|gb|AAD36092.1|AE001763_4 (AE001763)
glutamate dehydrogenase [Thermotoga maritima]
Length = 416
Score = 469 bits (1193), Expect = e-131
Identities = 231/416 (55%), Positives = 294/416 (70%), Gaps = 3/416 (0%)
Query: 1 MVEQDPFEIAVKQLERAAQYMKISEEALEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQ 60
M E+ +E+AV+Q RAA M + + E L+RP+R++ V PV MDDG V+VFTG+RVQ
Sbjct: 1 MPEKSLYEMAVEQFNRAASLMDLESDLAEVLRRPKRVLIVEFPVRMDDGHVEVFTGYRVQ 60
Query: 61 YNWARGPTKGGIRWHPEETLSTVKALAAWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREK 120
+N ARGP KGGIR+HP+ TL VKALA WMTWKTAVM+LP+GGGKGG+ VDPKKLS E
Sbjct: 61 HNVARGPAKGGIRYHPDVTLDEVKALAFWMTWKTAVMNLPFGGGKGGVRVDPKKLSRNEL 120
Query: 121 ERLARGYIRAIYDVISPYEDIPAPDVYTNPQIMAWMMDEYETIARRKTPAFGIITGKPLS 180
ERL+R + I +I PY DIPAPDV TN +MAW MD Y GI+TGKP+
Sbjct: 121 ERLSRRFFSEIQVIIGPYNDIPAPDVNTNADVMAWYMDTYSMNVGHTV--LGIVTGKPVE 178
Query: 181 IGGSLGRNEATARGASYTIREAAKVLGWDDLKGKTIAIQGYGNAGYYLAKIMSEDYGMKV 240
+GGS GR EAT RG A VLG D K T+A+QG+GN G + A ++S++ G KV
Sbjct: 179 LGGSKGREEATGRGVKVCAGLAMDVLGIDPKKA-TVAVQGFGNVGQFAALLISQELGSKV 237
Query: 241 VAVSDSKGGIYNPDGLNADEVLKWKREHGSVKDFPGATNITNEELLELEVDVLAPAAIEE 300
VAVSDS+GGIYNP+G + +E++++K+EHG+V +P ITNEELLEL+VD+L PAA+E
Sbjct: 238 VAVSDSRGGIYNPEGFDVEELIRYKKEHGTVVTYPKGERITNEELLELDVDILVPAALEG 297
Query: 301 VITKKNADNIKAKIVAEVANGPVTPEADEILFEKGILQIPDFLCNAGGVTVSYFEWVQNI 360
I NA+ IKAK V E ANGP TPEADEIL +GIL +PD L NAGGVTVSYFEWVQ++
Sbjct: 298 AIHAGNAERIKAKAVVEGANGPTTPEADEILSRRGILVVPDILANAGGVTVSYFEWVQDL 357
Query: 361 TGYYWTLEEVREKLDKKMTKAFYDVYNTAKEKNIHMRDAAYVVAVQRVYQAMLDRG 416
++W L++VR L+K M AF DV ++ N+ MR AAY++A+ RV A RG
Sbjct: 358 QSFFWDLDQVRNALEKMMKGAFNDVMKVKEKYNVDMRTAAYILAIDRVAYATKKRG 413
>pir||T45284 glutamate dehydrogenase (NAD(P)+) (EC 1.4.1.3) [validated] -
Thermotoga maritima >gi|6730075|pdb|1B26|A Chain A,
Glutamate Dehydrogenase >gi|6730076|pdb|1B26|B Chain B,
Glutamate Dehydrogenase >gi|6730077|pdb|1B26|C Chain C,
Glutamate Dehydrogenase >gi|6730078|pdb|1B26|D Chain D,
Glutamate Dehydrogenase >gi|6730079|pdb|1B26|E Chain E,
Glutamate Dehydrogenase >gi|6730080|pdb|1B26|F Chain F,
Glutamate Dehydrogenase >gi|1743418|emb|CAA71058.1|
(Y09925) glutamate dehydrogenase (NAD(P)+) [Thermotoga
maritima]
Length = 416
Score = 467 bits (1189), Expect = e-130
Identities = 230/416 (55%), Positives = 294/416 (70%), Gaps = 3/416 (0%)
Query: 1 MVEQDPFEIAVKQLERAAQYMKISEEALEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQ 60
M E+ +E+AV+Q RAA M + + E L+RP+R++ V PV MDDG V+VFTG+RVQ
Sbjct: 1 MPEKSLYEMAVEQFNRAASLMDLESDLAEVLRRPKRVLIVEFPVRMDDGHVEVFTGYRVQ 60
Query: 61 YNWARGPTKGGIRWHPEETLSTVKALAAWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREK 120
+N ARGP KGGIR+HP+ TL VKALA WMTWKTAVM+LP+GGGKGG+ VDPKKLS E
Sbjct: 61 HNVARGPAKGGIRYHPDVTLDEVKALAFWMTWKTAVMNLPFGGGKGGVRVDPKKLSRNEL 120
Query: 121 ERLARGYIRAIYDVISPYEDIPAPDVYTNPQIMAWMMDEYETIARRKTPAFGIITGKPLS 180
ERL+R + I +I PY DIPAPDV TN ++AW MD Y GI+TGKP+
Sbjct: 121 ERLSRRFFSEIQVIIGPYNDIPAPDVNTNADVIAWYMDTYSMNVGHTV--LGIVTGKPVE 178
Query: 181 IGGSLGRNEATARGASYTIREAAKVLGWDDLKGKTIAIQGYGNAGYYLAKIMSEDYGMKV 240
+GGS GR EAT RG A VLG D K T+A+QG+GN G + A ++S++ G KV
Sbjct: 179 LGGSKGREEATGRGVKVCAGLAMDVLGIDPKKA-TVAVQGFGNVGQFAALLISQELGSKV 237
Query: 241 VAVSDSKGGIYNPDGLNADEVLKWKREHGSVKDFPGATNITNEELLELEVDVLAPAAIEE 300
VAVSDS+GGIYNP+G + +E++++K+EHG+V +P ITNEELLEL+VD+L PAA+E
Sbjct: 238 VAVSDSRGGIYNPEGFDVEELIRYKKEHGTVVTYPKGERITNEELLELDVDILVPAALEG 297
Query: 301 VITKKNADNIKAKIVAEVANGPVTPEADEILFEKGILQIPDFLCNAGGVTVSYFEWVQNI 360
I NA+ IKAK V E ANGP TPEADEIL +GIL +PD L NAGGVTVSYFEWVQ++
Sbjct: 298 AIHAGNAERIKAKAVVEGANGPTTPEADEILSRRGILVVPDILANAGGVTVSYFEWVQDL 357
Query: 361 TGYYWTLEEVREKLDKKMTKAFYDVYNTAKEKNIHMRDAAYVVAVQRVYQAMLDRG 416
++W L++VR L+K M AF DV ++ N+ MR AAY++A+ RV A RG
Sbjct: 358 QSFFWDLDQVRNALEKMMKGAFNDVMKVKEKYNVDMRTAAYILAIDRVAYATKKRG 413
>sp|P50735|GUDB_BACSU NAD-SPECIFIC GLUTAMATE DEHYDROGENASE (NAD-GDH)
>gi|7431766|pir||G69933 glutamate dehydrogenase homolog
ypcA - Bacillus subtilis >gi|1146206|gb|AAC83953.1|
(L47648) glutamate dehydrogenase [Bacillus subtilis]
>gi|2634714|emb|CAB14212.1| (Z99115) similar to
glutamate dehydrogenase [Bacillus subtilis]
>gi|2634731|emb|CAB14228.1| (Z99116) similar to
glutamate dehydrogenase [Bacillus subtilis]
Length = 426
Score = 436 bits (1109), Expect = e-121
Identities = 222/408 (54%), Positives = 291/408 (70%), Gaps = 9/408 (2%)
Query: 14 LERAAQYMKISEEALEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQYNWARGPTKGGIR 73
+ +A + + EE E LK P R++ V IPV MDDGSVK+FTG+R +N + GPTKGGIR
Sbjct: 25 IHKALEKLGYPEEVYELLKEPMRLLTVKIPVRMDDGSVKIFTGYRA-HNDSVGPTKGGIR 83
Query: 74 WHP---EETLSTVKALAAWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREKERLARGYIRA 130
+HP E+ + VKAL+ WM+ K ++DLPYGGGKGGI+ DP+ +S RE ERL+RGY+RA
Sbjct: 84 FHPNVTEKEVKAVKALSIWMSLKCGIIDLPYGGGKGGIVCDPRDMSFRELERLSRGYVRA 143
Query: 131 IYDVISPYEDIPAPDVYTNPQIMAWMMDEYETIARRKTPAFGIITGKPLSIGGSLGRNEA 190
I ++ P +D+PAPDV+TN QIMAWMMDEY I +P F ITGKPL +GGS GR A
Sbjct: 144 ISQIVGPTKDVPAPDVFTNSQIMAWMMDEYSRIDEFNSPGF--ITGKPLVLGGSHGRESA 201
Query: 191 TARGASYTIREAAKVLGWDDLKGKTIAIQGYGNAGYYLAKIMSEDYGMKVVAVSDSKGGI 250
TA+G + I+EAAK G D +KG + +QG+GNAG YLAK M D G KVV +SD+ GG+
Sbjct: 202 TAKGVTICIKEAAKKRGID-IKGARVVVQGFGNAGSYLAKFM-HDAGAKVVGISDAYGGL 259
Query: 251 YNPDGLNADEVLKWKREHGSVKDFPGATNITNEELLELEVDVLAPAAIEEVITKKNADNI 310
Y+P+GL+ D +L + G+V T ITN+ELLEL+ D+L PAAIE IT++NA NI
Sbjct: 260 YDPEGLDIDYLLDRRDSFGTVTKLFNDT-ITNQELLELDCDILVPAAIENQITEENAHNI 318
Query: 311 KAKIVAEVANGPVTPEADEILFEKGILQIPDFLCNAGGVTVSYFEWVQNITGYYWTLEEV 370
+AKIV E ANGP T E +IL ++ IL +PD L +AGGVTVSYFEWVQN G+YW+ EEV
Sbjct: 319 RAKIVVEAANGPTTLEGTKILSDRDILLVPDVLASAGGVTVSYFEWVQNNQGFYWSEEEV 378
Query: 371 REKLDKKMTKAFYDVYNTAKEKNIHMRDAAYVVAVQRVYQAMLDRGWV 418
EKL+K M K+F ++Y A + I MR AAY+V V+++ +A RGW+
Sbjct: 379 EEKLEKMMVKSFNNIYEMANNRRIDMRLAAYMVGVRKMAEASRFRGWI 426
>dbj|BAB05341.1| (AP001512) glutamate dehydrogenase [Bacillus halodurans]
Length = 421
Score = 432 bits (1099), Expect = e-120
Identities = 221/405 (54%), Positives = 285/405 (69%), Gaps = 5/405 (1%)
Query: 14 LERAAQYMKISEEALEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQYNWARGPTKGGIR 73
+++A + +E E +K P R++ V IPV MDDGS K+FTG+R Q+N A GPTKGG+R
Sbjct: 22 IKKALDKLGYPDEMYELMKEPIRMLTVRIPVRMDDGSTKIFTGYRAQHNDAVGPTKGGVR 81
Query: 74 WHPEETLSTVKALAAWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREKERLARGYIRAIYD 133
+HP T VKAL+ WM+ K ++DLPYGGGKGGI+ DP+ +S RE ERL+RGY+RAI
Sbjct: 82 FHPNVTEKEVKALSIWMSLKAGIVDLPYGGGKGGIVCDPRDMSFRELERLSRGYVRAISQ 141
Query: 134 VISPYEDIPAPDVYTNPQIMAWMMDEYETIARRKTPAFGIITGKPLSIGGSLGRNEATAR 193
++ P +DIPAPDV+TN QIMAWM+DEY I +P G ITGKP+ +GGS GR ATA+
Sbjct: 142 IVGPTKDIPAPDVFTNSQIMAWMLDEYSRIREFDSP--GFITGKPIVLGGSHGRESATAK 199
Query: 194 GASYTIREAAKVLGWDDLKGKTIAIQGYGNAGYYLAKIMSEDYGMKVVAVSDSKGGIYNP 253
G + IREAAK G DL+ + IQG+GNAG +LAK M D G KV+ +SD+ G +++P
Sbjct: 200 GVTICIREAAKKKG-IDLQDARVVIQGFGNAGSFLAKFM-HDAGAKVIGISDAYGALHDP 257
Query: 254 DGLNADEVLKWKREHGSVKDFPGATNITNEELLELEVDVLAPAAIEEVITKKNADNIKAK 313
DGL+ D +L + G+V T I+NEELLEL+ D+L PAAIE IT+KNA NIKA+
Sbjct: 258 DGLDIDYLLDRRDSFGTVTKLFKNT-ISNEELLELDCDILVPAAIENQITEKNAHNIKAQ 316
Query: 314 IVAEVANGPVTPEADEILFEKGILQIPDFLCNAGGVTVSYFEWVQNITGYYWTLEEVREK 373
IV E ANGP T EA EIL + IL +PD L +AGGVTVSYFEWVQN GYYWT EEV K
Sbjct: 317 IVVEAANGPTTIEATEILTNRDILLVPDVLASAGGVTVSYFEWVQNNQGYYWTEEEVEGK 376
Query: 374 LDKKMTKAFYDVYNTAKEKNIHMRDAAYVVAVQRVYQAMLDRGWV 418
L+ M AF ++Y AK + + MR AAY+V V+++ +A RGWV
Sbjct: 377 LEAVMVHAFDNIYKLAKGRKVDMRLAAYMVGVRKMAEASRFRGWV 421
>sp|P27346|DHE2_CLODI NAD-SPECIFIC GLUTAMATE DEHYDROGENASE (NAD-GDH)
>gi|282476|pir||S28829 glutamate dehydrogenase (EC
1.4.1.2) - Clostridium difficile
>gi|144820|gb|AAA62756.1| (M65250) glutamate
dehydrogenase [Clostridium difficile]
Length = 421
Score = 418 bits (1062), Expect = e-116
Identities = 216/416 (51%), Positives = 285/416 (67%), Gaps = 9/416 (2%)
Query: 7 FEIAVKQLERAAQYMKISEEALEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQYNWARG 66
FE+A Q++ A + + E LK P R++EV+IPV+MDDGS+K F GFR Q+N A G
Sbjct: 9 FEMAQSQVKNACDKLGMEPAVYELLKEPMRVIEVSIPVKMDDGSIKTFKGFRSQHNDAVG 68
Query: 67 PTKGGIRWHPEETLSTVKALAAWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREKERLARG 126
PTKGGIR+H + VKAL+ WMT+K +V +PYGGGKGGIIVDP LS E ERL+RG
Sbjct: 69 PTKGGIRFHQNVSRDEVKALSIWMTFKCSVTGIPYGGGKGGIIVDPSTLSQGELERLSRG 128
Query: 127 YIRAIYDVISPYEDIPAPDVYTNPQIMAWMMDEYETIARRKTPAFGIITGKPLSIGGSLG 186
YI IY +I D+PAPDV TN QIM+WM+DEY + + + G+ITGKP+ GGSLG
Sbjct: 129 YIDGIYKLIGEKVDVPAPDVNTNGQIMSWMVDEYNKLTGQSS--IGVITGKPVEFGGSLG 186
Query: 187 RNEATARGASYTIREAAKVLGWDDLKGKTIAIQGYGNAGYYLAKIMSEDYGMKVVAVSD- 245
R AT G + T REAA LG D K K IA+QG GN G Y + E G VVA+++
Sbjct: 187 RTAATGFGVAVTAREAAAKLGIDMKKAK-IAVQGIGNVGSYTV-LNCEKLGGTVVAMAEW 244
Query: 246 --SKGG--IYNPDGLNADEVLKWKREHGSVKDFPGATNITNEELLELEVDVLAPAAIEEV 301
S+G IYN +GL+ +L + +EHG++ +FPGA I+ EE +VD++ PAA+E
Sbjct: 245 CKSEGSYAIYNENGLDGQAMLDYMKEHGNLLNFPGAKRISLEEFWASDVDIVIPAALENS 304
Query: 302 ITKKNADNIKAKIVAEVANGPVTPEADEILFEKGILQIPDFLCNAGGVTVSYFEWVQNIT 361
ITK+ A++IKAK+V E ANGP TPEADE+ E+GI+ PD L NAGGVTVSYFEWVQN+
Sbjct: 305 ITKEVAESIKAKLVCEAANGPTTPEADEVFAERGIVLTPDILTNAGGVTVSYFEWVQNLY 364
Query: 362 GYYWTLEEVREKLDKKMTKAFYDVYNTAKEKNIHMRDAAYVVAVQRVYQAMLDRGW 417
GYYW+ EEV +K + M KAF ++ +E N+ MR+AAY+ ++++V +AM RGW
Sbjct: 365 GYYWSEEEVEQKEEIAMVKAFESIWKIKEEYNVTMREAAYMHSIKKVAEAMKLRGW 420
>sp|P39633|YWEB_BACSU HYPOTHETICAL 46.6 KD OXIDOREDUCTASE IN UNG-ROCA INTERGENIC REGION
>gi|7431765|pir||A70055 glutamate dehydrogenase homolog
yweB - Bacillus subtilis >gi|2636315|emb|CAB15806.1|
(Z99123) alternate gene name: ipa-75d~similar to
glutamate dehydrogenase [Bacillus subtilis]
Length = 424
Score = 416 bits (1059), Expect = e-115
Identities = 217/405 (53%), Positives = 275/405 (67%), Gaps = 5/405 (1%)
Query: 14 LERAAQYMKISEEALEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQYNWARGPTKGGIR 73
++ A + + + E +K PQR++ V IPV+MD+GSVKVFTG+R Q+N A GPTKGG+R
Sbjct: 25 IKEALRKLGYPGDMYELMKEPQRMLTVRIPVKMDNGSVKVFTGYRSQHNDAVGPTKGGVR 84
Query: 74 WHPEETLSTVKALAAWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREKERLARGYIRAIYD 133
+HPE VKAL+ WMT K + +LPYGGGKGGII DP+ +S E ERL+RGY+RAI
Sbjct: 85 FHPEVNEEEVKALSIWMTLKCGIANLPYGGGKGGIICDPRTMSFGELERLSRGYVRAISQ 144
Query: 134 VISPYEDIPAPDVYTNPQIMAWMMDEYETIARRKTPAFGIITGKPLSIGGSLGRNEATAR 193
++ P +DIPAPDVYTN QIMAWMMDEY + +P G ITGKPL +GGS GR ATA+
Sbjct: 145 IVGPTKDIPAPDVYTNSQIMAWMMDEYSRLREFDSP--GFITGKPLVLGGSQGRETATAQ 202
Query: 194 GASYTIREAAKVLGWDDLKGKTIAIQGYGNAGYYLAKIMSEDYGMKVVAVSDSKGGIYNP 253
G + I EA K G L+ I IQG+GNAG +LAK M D G KV+ +SD+ GG+YNP
Sbjct: 203 GVTICIEEAVKKKG-IKLQNARIIIQGFGNAGSFLAKFM-HDAGAKVIGISDANGGLYNP 260
Query: 254 DGLNADEVLKWKREHGSVKDFPGATNITNEELLELEVDVLAPAAIEEVITKKNADNIKAK 313
DGL+ +L + G V + ITNEELLE + D+L PAAI IT KNA NI+A
Sbjct: 261 DGLDIPYLLDKRDSFGMVTNL-FTDVITNEELLEKDCDILVPAAISNQITAKNAHNIQAS 319
Query: 314 IVAEVANGPVTPEADEILFEKGILQIPDFLCNAGGVTVSYFEWVQNITGYYWTLEEVREK 373
IV E ANGP T +A +IL E+G+L +PD L +AGGVTVSYFEWVQN GYYW+ EEV EK
Sbjct: 320 IVVERANGPTTIDATKILNERGVLLVPDILASAGGVTVSYFEWVQNNQGYYWSEEEVAEK 379
Query: 374 LDKKMTKAFYDVYNTAKEKNIHMRDAAYVVAVQRVYQAMLDRGWV 418
L M +F +Y TA + MR AAY+ +++ +A RGWV
Sbjct: 380 LRSVMVSSFETIYQTAATHKVDMRLAAYMTGIRKSAEASRFRGWV 424
>dbj|BAB07661.1| (AP001520) glutamate dehydrogenase [Bacillus halodurans]
Length = 420
Score = 415 bits (1056), Expect = e-115
Identities = 215/405 (53%), Positives = 279/405 (68%), Gaps = 5/405 (1%)
Query: 14 LERAAQYMKISEEALEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQYNWARGPTKGGIR 73
+++A + E E LK P R++ V IPV MDDG+VKVFTG+R Q+N A GPTKGG+R
Sbjct: 21 IQQALGKLGYEEGMFELLKEPVRMLTVRIPVRMDDGTVKVFTGYRAQHNDAVGPTKGGVR 80
Query: 74 WHPEETLSTVKALAAWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREKERLARGYIRAIYD 133
+HPE T VKAL+ WMT K ++++PYGGGKGGI+ DP+ +S E ERL+RGY+RAI
Sbjct: 81 FHPEVTADEVKALSLWMTLKCGIVNIPYGGGKGGIVCDPRTMSFPEIERLSRGYVRAISQ 140
Query: 134 VISPYEDIPAPDVYTNPQIMAWMMDEYETIARRKTPAFGIITGKPLSIGGSLGRNEATAR 193
++ P +DIPAPDV+TN QIMAWM+DEY I +P G ITGKP+ +GGS GR ATA
Sbjct: 141 IVGPSKDIPAPDVFTNSQIMAWMVDEYSRIREFDSP--GFITGKPIVLGGSHGRETATAM 198
Query: 194 GASYTIREAAKVLGWDDLKGKTIAIQGYGNAGYYLAKIMSEDYGMKVVAVSDSKGGIYNP 253
G + I EAAK L DL+ T+ IQG+GNAG YLAKI+S D G K++ +SD+ G +Y+
Sbjct: 199 GVTICIEEAAK-LKQLDLREATVIIQGFGNAGGYLAKILS-DRGAKIIGISDAYGALYDE 256
Query: 254 DGLNADEVLKWKREHGSVKDFPGATNITNEELLELEVDVLAPAAIEEVITKKNADNIKAK 313
GL+ + +L + G+V T ITNEELLE + D+L PAAI IT+ NA IKA
Sbjct: 257 TGLDIEYLLDRRDSFGTVTTLFKNT-ITNEELLEKKCDILVPAAIANQITEANAREIKAS 315
Query: 314 IVAEVANGPVTPEADEILFEKGILQIPDFLCNAGGVTVSYFEWVQNITGYYWTLEEVREK 373
I+ E ANGP T EA IL E+G+L +PD L ++GGVTVSYFEWVQN GYYW+ EEV EK
Sbjct: 316 IIVEAANGPTTTEATNILTERGVLIVPDVLASSGGVTVSYFEWVQNNLGYYWSEEEVSEK 375
Query: 374 LDKKMTKAFYDVYNTAKEKNIHMRDAAYVVAVQRVYQAMLDRGWV 418
L K+ +AF+ V TA N+ R AAY+V V++ +A RGW+
Sbjct: 376 LRSKIVEAFHQVVETATRYNVDPRLAAYMVGVRKTAEASRFRGWI 420
>sp|Q9YC65|DHE3_AERPE GLUTAMATE DEHYDROGENASE (GDH) >gi|7431771|pir||A72616 probable
glutamate dehydrogenase APE1386 - Aeropyrum pernix
(strain K1) >gi|5105069|dbj|BAA80383.1| (AP000061) 423aa
long hypothetical glutamate dehydrogenase [Aeropyrum
pernix]
Length = 423
Score = 411 bits (1045), Expect = e-114
Identities = 211/420 (50%), Positives = 291/420 (69%), Gaps = 12/420 (2%)
Query: 5 DPFEIAVKQLERAAQYMKISEEALEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQYNWA 64
DP E A QL RA + + E L P R+++V + ++MDDG+VK F G+R Q+N A
Sbjct: 10 DPLEEARAQLRRAVDLLGYDDYVYEVLANPDRVLQVRVTIKMDDGTVKTFLGWRSQHNSA 69
Query: 65 RGPTKGGIRWHPEETLSTVKALAAWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREKERLA 124
GP KGG+R+HP T++ V AL+ WMTWK ++ LPYGGGKGG+ V+PK LS RE E L+
Sbjct: 70 LGPYKGGVRYHPNVTMNEVIALSMWMTWKNSLAGLPYGGGKGGVRVNPKILSPRELELLS 129
Query: 125 RGYIRAIYDVISPYEDIPAPDVYTNPQIMAWMMDEYETIARRKTPAFGIITGKPLSIGGS 184
R Y +I D++ +DIPAPDVYT+PQ+M+W +DEY + R + FG++TGKP+ +GG
Sbjct: 130 RKYFESISDIVGVDQDIPAPDVYTDPQVMSWFLDEYNRVKRGQ--FFGVVTGKPVELGGL 187
Query: 185 LGRNEATARGASYTIREAA-KVLGWDDLKGKTIAIQGYGNAGYYLAKIMSEDYGMKVVAV 243
R +T G + + R AA K LG L+G+T+A+QGYGN GYY AK ++E G K+VAV
Sbjct: 188 NARIVSTGYGVAVSTRVAAEKFLG--GLEGRTVAVQGYGNVGYYAAKFLAE-MGAKIVAV 244
Query: 244 SDSKGGIYNPDGLNADEVLKWKREHGSVKDFPGATNITNEELLELEVDVLAPAAIEEVIT 303
SDS+GGIY+P+G++ +E LK KR G+V ++ I+ E+LEL VD+L PAAIEEVIT
Sbjct: 245 SDSRGGIYDPEGIDPEEALKVKRSTGTVANYQRGKKISTMEILELPVDILVPAAIEEVIT 304
Query: 304 KKNADNIKAKIVAEVANGPVTPEADEILFEKGILQIPDFLCNAGGVTVSYFEWVQNITGY 363
+NAD IKAKI++E ANGP T A++IL +KG+L +PD L NAGGV +S+ EWV N G
Sbjct: 305 DENADRIKAKIISEGANGPTTTAAEKILVKKGVLVLPDILANAGGVIMSHIEWVNNRMGG 364
Query: 364 YWTLEEVREKLDKKMTKAFYDVYNTAKEKNI-----HMRDAAYVVAVQRVYQAMLDRGWV 418
+ T EE +KL++KM + V T EKN+ +RDAAY++AV+RV++AM RGW+
Sbjct: 365 WITDEEALKKLEQKMVENTKTVI-TYWEKNLKPEENSLRDAAYMIAVERVFRAMKLRGWI 423
>pir||S39730 hypothetical protein - Bacillus subtilis >gi|413999|emb|CAA51631.1|
(X73124) ipa-75d [Bacillus subtilis]
Length = 425
Score = 410 bits (1042), Expect = e-113
Identities = 214/402 (53%), Positives = 272/402 (67%), Gaps = 5/402 (1%)
Query: 14 LERAAQYMKISEEALEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQYNWARGPTKGGIR 73
++ A + + + E +K PQR++ V IPV+MD+GSVKVFTG+R Q+N A GPTKGG+R
Sbjct: 25 IKEALRKLGYPGDMYELMKEPQRMLTVRIPVKMDNGSVKVFTGYRSQHNDAVGPTKGGVR 84
Query: 74 WHPEETLSTVKALAAWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREKERLARGYIRAIYD 133
+HPE VKAL+ WMT K + +LPYGGGKGGII DP+ +S E ERL+RGY+RAI
Sbjct: 85 FHPEVNEEEVKALSIWMTLKCGIANLPYGGGKGGIICDPRTMSFGELERLSRGYVRAISQ 144
Query: 134 VISPYEDIPAPDVYTNPQIMAWMMDEYETIARRKTPAFGIITGKPLSIGGSLGRNEATAR 193
++ P +DIPAPDVYTN QIMAWMMDEY + +P G ITGKPL +GGS GR ATA+
Sbjct: 145 IVGPTKDIPAPDVYTNSQIMAWMMDEYSRLREFDSP--GFITGKPLVLGGSQGRETATAQ 202
Query: 194 GASYTIREAAKVLGWDDLKGKTIAIQGYGNAGYYLAKIMSEDYGMKVVAVSDSKGGIYNP 253
G + I EA K G L+ I IQG+GNAG +LAK M D G KV+ +SD+ GG+YNP
Sbjct: 203 GVTICIEEAVKKKG-IKLQNARIIIQGFGNAGSFLAKFM-HDAGAKVIGISDANGGLYNP 260
Query: 254 DGLNADEVLKWKREHGSVKDFPGATNITNEELLELEVDVLAPAAIEEVITKKNADNIKAK 313
DGL+ +L + G V + ITNEELLE + D+L PAAI IT KNA NI+A
Sbjct: 261 DGLDIPYLLDKRDSFGMVTNL-FTDVITNEELLEKDCDILVPAAISNQITAKNAHNIQAS 319
Query: 314 IVAEVANGPVTPEADEILFEKGILQIPDFLCNAGGVTVSYFEWVQNITGYYWTLEEVREK 373
IV E ANGP T +A +IL E+G+L +PD L +AGGVTVSYFEWVQN GYYW+ EEV EK
Sbjct: 320 IVVERANGPTTIDATKILNERGVLLVPDILASAGGVTVSYFEWVQNNQGYYWSEEEVAEK 379
Query: 374 LDKKMTKAFYDVYNTAKEKNIHMRDAAYVVAVQRVYQAMLDR 415
L M +F +Y TA + MR AAY+ +++ +A R
Sbjct: 380 LRSVMVSSFETIYQTAATHKVDMRLAAYMTGIRKSAEASFPR 421
>pir||B81079 glutamate dehydrogenase, NAD-specific NMB1476 [imported] -
Neisseria meningitidis (group B strain MD58)
>gi|7226717|gb|AAF41833.1| (AE002497) glutamate
dehydrogenase, NAD-specific [Neisseria meningitidis
MC58]
Length = 421
Score = 404 bits (1026), Expect = e-111
Identities = 206/414 (49%), Positives = 274/414 (65%), Gaps = 5/414 (1%)
Query: 5 DPFEIAVKQLERAAQYMKISEEALEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQYNWA 64
+PFEIA KQ++ A +K E LK P R++EV PV++DD +VK FTG+R Q+N A
Sbjct: 11 NPFEIARKQVKTACDRLKTDPAVYEILKSPTRVLEVNFPVKLDDDTVKTFTGYRSQHNNA 70
Query: 65 RGPTKGGIRWHPEETLSTVKALAAWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREKERLA 124
GP KGG+R+HP L VKAL+ WMT K V +PYGGGKGGI +DP+ S+ E ER+A
Sbjct: 71 VGPYKGGVRFHPSVNLDEVKALSIWMTIKCCVAGIPYGGGKGGITLDPRDYSEAELERIA 130
Query: 125 RGYIRAIYDVISPYEDIPAPDVYTNPQIMAWMMDEYETIARRKTPAFGIITGKPLSIGGS 184
R Y AI +I DIPAPDV TN +IM+WM+D YE + + P G+ TGKP+ GGS
Sbjct: 131 RAYAEAIAPLIGEKIDIPAPDVNTNGKIMSWMVDAYENVVKHSAP--GVFTGKPVEFGGS 188
Query: 185 LGRNEATARGASYTIREAAKVLGWDDLKGKTIAIQGYGNAGYYLAKIMSEDYGMKVVAVS 244
L R EAT G + +A + LG D+KG T AIQG+GN GY+ + G KVVAVS
Sbjct: 189 LARTEATGYGVNLAAVQALEKLG-KDVKGATYAIQGFGNVGYHTG-YYAHQSGAKVVAVS 246
Query: 245 DSKGGIYNPDGLNADEVLKWKREHGSVKDFPG-ATNITNEELLELEVDVLAPAAIEEVIT 303
IYN +GL+ + + K +E G + + G ITN ELL L+VDVLAP A+E +T
Sbjct: 247 TVDVAIYNENGLDMEALFKEFQEKGFITNEAGYGKEITNAELLALDVDVLAPCALENQLT 306
Query: 304 KKNADNIKAKIVAEVANGPVTPEADEILFEKGILQIPDFLCNAGGVTVSYFEWVQNITGY 363
+NA ++AKIV E ANGP TPEAD IL + G+L +PD L N GGV VSYFEWVQN+ GY
Sbjct: 307 SENAGKVRAKIVVEGANGPTTPEADVILRQNGVLVVPDILANCGGVVVSYFEWVQNLQGY 366
Query: 364 YWTLEEVREKLDKKMTKAFYDVYNTAKEKNIHMRDAAYVVAVQRVYQAMLDRGW 417
YW +EV+EK + +AF D++N A+E ++ +R A+Y+++++RV +AM RGW
Sbjct: 367 YWEFDEVQEKETVVLRRAFRDIWNLAQEYDVDLRTASYMMSIRRVEKAMKLRGW 420
>sp|P54386|DHE4_SYNY3 NADP-SPECIFIC GLUTAMATE DEHYDROGENASE (NADP-GDH)
>gi|1361331|pir||S56683 glutamate dehydrogenase (NADP+)
(EC 1.4.1.4) - Synechocystis sp >gi|7431778|pir||S77064
glutamate dehydrogenase (NADP+) (EC 1.4.1.4) -
Synechocystis sp. (strain PCC 6803)
>gi|1006603|dbj|BAA10756.1| (D64005) glutamate
dehydrogenase (NADP+) [Synechocystis sp.]
>gi|1006751|emb|CAA54601.1| (X77454) glutamate
dehydrogenase (NADP+) [Synechocystis sp.]
Length = 428
Score = 402 bits (1022), Expect = e-111
Identities = 207/420 (49%), Positives = 292/420 (69%), Gaps = 15/420 (3%)
Query: 7 FEIAVKQLERAAQYMKISEEALEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQYNWARG 66
F A K+LE+A +Y+ IS++A E LK P+ + V+IPV MDDGS+K+F G+RV+Y+ RG
Sbjct: 6 FADASKRLEKALKYVAISDDAGERLKYPKTSLSVSIPVRMDDGSLKIFPGYRVRYDDTRG 65
Query: 67 PTKGGIRWHPEETLSTVKALAAWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREKERLARG 126
P KGG+R+HP T+ V++LA WMT+K A+++LP+GG KGGI ++PK+LS E ERL+RG
Sbjct: 66 PGKGGVRYHPNVTMDEVQSLAFWMTFKCALLNLPFGGAKGGITLNPKELSRAELERLSRG 125
Query: 127 YIRAIYDVISPYEDIPAPDVYTNPQIMAWMMDEYETIARRKTPAFGIITGKPLSIGGSLG 186
YI AI D I P DI APDVYTN +M WMMD+Y I R+ +PA ++TGKP+++GGS G
Sbjct: 126 YIEAIADFIGPDIDILAPDVYTNEMMMGWMMDQYSIIRRKISPA--VVTGKPVTMGGSQG 183
Query: 187 RNEATARGASYTIREAAKVLGWDDL-KGKTIAIQGYGNAGYYLAKIMSEDYGMKVVAVSD 245
RN AT GA Y ++ + +D + T+A+QG+GNAG +A+ + +D G KVVA+SD
Sbjct: 184 RNTATGTGAFYIMQ--GMLPKFDQYPENTTVAVQGFGNAGMVVAECLYQD-GYKVVAISD 240
Query: 246 SKGGIYNPDGLNADEVLKWKREH---------GSVKDFPGATNITNEELLELEVDVLAPA 296
S+GGIYN G++ V+ +K+ H ++ D I+N ELL L+VDVL PA
Sbjct: 241 SQGGIYNEQGIDIPAVIDYKQRHRTLAGMYCDQAICDLGENQQISNAELLALDVDVLIPA 300
Query: 297 AIEEVITKKNADNIKAKIVAEVANGPVTPEADEILFEKGILQIPDFLCNAGGVTVSYFEW 356
A+E IT+ NAD ++A+ + EVANGP T AD+IL KGI PD L NAGGVTVSYFEW
Sbjct: 301 ALENQITRDNADQVRARYIFEVANGPTTTAADDILASKGIYVFPDILVNAGGVTVSYFEW 360
Query: 357 VQNITGYYWTLEEVREKLDKKMTKAFYDVYNTAKEKNIHMRDAAYVVAVQRVYQAMLDRG 416
VQN +G YW+ +EV ++L +KM + V+N +E ++++R AAY+ A+ R+ +AM +G
Sbjct: 361 VQNRSGLYWSAKEVNDRLKEKMVEEAEHVWNITQELDVNVRTAAYIHALNRLSEAMDAKG 420
>pir||B81864 probable glutamate dehydrogenase (EC 1.4.1.2) NMA1687 [imported] -
Neisseria meningitidis (group A strain Z2491)
>gi|7380328|emb|CAB84915.1| (AL162756) putative
glutamate dehydrogenase [Neisseria meningitidis Z2491]
Length = 421
Score = 401 bits (1019), Expect = e-111
Identities = 205/414 (49%), Positives = 274/414 (65%), Gaps = 5/414 (1%)
Query: 5 DPFEIAVKQLERAAQYMKISEEALEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQYNWA 64
+PFEIA KQ++ A +K E L+ P R++EV PV++DD +VK FTG+R Q+N A
Sbjct: 11 NPFEIARKQVKTACDRLKTDPAVYEILESPTRVLEVNFPVKLDDDTVKTFTGYRSQHNNA 70
Query: 65 RGPTKGGIRWHPEETLSTVKALAAWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREKERLA 124
GP KGG+R+HP L VKAL+ WMT K V +PYGGGKGGI +DP+ S+ E ER+A
Sbjct: 71 VGPYKGGVRFHPGVNLDEVKALSIWMTIKCCVAGIPYGGGKGGITLDPRDYSEAELERIA 130
Query: 125 RGYIRAIYDVISPYEDIPAPDVYTNPQIMAWMMDEYETIARRKTPAFGIITGKPLSIGGS 184
R Y AI +I DIPAPDV TN +IM+WM+D YE + + P G+ TGKP+ GGS
Sbjct: 131 RAYSEAISPLIGEKIDIPAPDVNTNGKIMSWMVDAYENVVKHSAP--GVFTGKPVEFGGS 188
Query: 185 LGRNEATARGASYTIREAAKVLGWDDLKGKTIAIQGYGNAGYYLAKIMSEDYGMKVVAVS 244
L R EAT G + +A + LG D+KG T AIQG+GN GY+ + G KVVAVS
Sbjct: 189 LARTEATGYGVNLAAVQALEKLG-KDVKGATYAIQGFGNVGYHTG-YYAHQSGAKVVAVS 246
Query: 245 DSKGGIYNPDGLNADEVLKWKREHGSVKDFPG-ATNITNEELLELEVDVLAPAAIEEVIT 303
IYN +GL+ + + K +E G + + G ITN ELL L+VDVLAP A+E +T
Sbjct: 247 TVDVAIYNENGLDMEALFKEFQEKGFITNEAGYGKEITNAELLALDVDVLAPCALENQLT 306
Query: 304 KKNADNIKAKIVAEVANGPVTPEADEILFEKGILQIPDFLCNAGGVTVSYFEWVQNITGY 363
+NA ++AKIV E ANGP TPEAD IL + G+L +PD L N GGV VSYFEWVQN+ GY
Sbjct: 307 SENAGKVRAKIVVEGANGPTTPEADVILRQNGVLVVPDILANCGGVVVSYFEWVQNLQGY 366
Query: 364 YWTLEEVREKLDKKMTKAFYDVYNTAKEKNIHMRDAAYVVAVQRVYQAMLDRGW 417
YW +EV+EK + +AF D++N A+E ++ +R A+Y+++++RV +AM RGW
Sbjct: 367 YWEFDEVQEKETVVLRRAFRDIWNLAQEYDVDLRTASYMMSIRRVEKAMKLRGW 420
>dbj|BAB06437.1| (AP001516) glutamate dehydrogenase [Bacillus halodurans]
Length = 430
Score = 398 bits (1012), Expect = e-110
Identities = 206/405 (50%), Positives = 271/405 (66%), Gaps = 5/405 (1%)
Query: 14 LERAAQYMKISEEALEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQYNWARGPTKGGIR 73
++ A + SE E LK P R++ V IPV MDDG+V +FTG+R Q+N A GPTKGG+R
Sbjct: 31 IKEALDLLGYSEATYELLKEPIRMLTVRIPVRMDDGNVNIFTGYRAQHNDAVGPTKGGVR 90
Query: 74 WHPEETLSTVKALAAWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREKERLARGYIRAIYD 133
+HP+ + VKAL+ WM+ K + DLPYGGGKGGII DP+ +S E ERL+RGY+RAI
Sbjct: 91 FHPDVNENEVKALSLWMSLKCGIADLPYGGGKGGIICDPRTMSFGELERLSRGYVRAISQ 150
Query: 134 VISPYEDIPAPDVYTNPQIMAWMMDEYETIARRKTPAFGIITGKPLSIGGSLGRNEATAR 193
++ P +DIPAPDV+TN Q+MAWMMDEY I +P G ITGKP+ +GGSLGR ATA+
Sbjct: 151 IVGPTKDIPAPDVFTNSQVMAWMMDEYSRIREFDSP--GFITGKPIVLGGSLGRESATAK 208
Query: 194 GASYTIREAAKVLGWDDLKGKTIAIQGYGNAGYYLAKIMSEDYGMKVVAVSDSKGGIYNP 253
G I EAAK DLKG + IQG+GNAG +LAK + D G +V +SD+ G +Y+
Sbjct: 209 GVIICIEEAAK-RNQLDLKGARVIIQGFGNAGSFLAKFL-HDAGALIVGISDAYGALYDQ 266
Query: 254 DGLNADEVLKWKREHGSVKDFPGATNITNEELLELEVDVLAPAAIEEVITKKNADNIKAK 313
GL+ + +L + G+V + T I+N+ELL + D+L PAAI ITK+NA +IKAK
Sbjct: 267 AGLDIEYLLDKRDSFGTVTNLFKKT-ISNQELLISDCDILVPAAISNQITKENAHDIKAK 325
Query: 314 IVAEVANGPVTPEADEILFEKGILQIPDFLCNAGGVTVSYFEWVQNITGYYWTLEEVREK 373
+V E ANGP T EA IL E+GI +PD L ++GGVTVSYFEWVQN GYYW EE+ +K
Sbjct: 326 VVVEAANGPTTLEATRILTERGIFLVPDVLASSGGVTVSYFEWVQNNQGYYWNEEEIDQK 385
Query: 374 LDKKMTKAFYDVYNTAKEKNIHMRDAAYVVAVQRVYQAMLDRGWV 418
+ +F V + + + MR AAY V V+R+ +A RGWV
Sbjct: 386 FRNMIVGSFEKVCTFSNQHQVDMRLAAYTVGVKRMAEASHFRGWV 430
>sp|P28997|DHE2_PEPAS NAD-SPECIFIC GLUTAMATE DEHYDROGENASE (NAD-GDH)
>gi|79826|pir||A38168 glutamate dehydrogenase (EC
1.4.1.2) - Peptostreptococcus asaccharolyticus
>gi|150670|gb|AAA25611.1| (M76403) glutamate
dehydrogenase [Peptostreptococcus asaccharolyticus]
Length = 421
Score = 378 bits (960), Expect = e-104
Identities = 193/418 (46%), Positives = 270/418 (64%), Gaps = 8/418 (1%)
Query: 5 DPFEIAVKQLERAAQYMKISEEALEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQYNWA 64
+P A +++ A + + E LK PQR++E++IPV+MDDG+VKVF G+R ++ A
Sbjct: 6 NPLVAAQEKVRIACEKLGCDPAVYELLKEPQRVIEISIPVKMDDGTVKVFKGWRSAHSSA 65
Query: 65 RGPTKGGIRWHPEETLSTVKALAAWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREKERLA 124
GP+KGG+R+HP + VKAL+ WMT+K + LPYGGGKGGI VDP +LS+RE E+L+
Sbjct: 66 VGPSKGGVRFHPNVNMDEVKALSLWMTFKGGALGLPYGGGKGGICVDPAELSERELEQLS 125
Query: 125 RGYIRAIYDVISPYEDIPAPDVYTNPQIMAWMMDEYETIARRKTPAFGIITGKPLSIGGS 184
RG++R +Y + DIPAPDV TN QIM+W +DEY + + G TGKP++ GGS
Sbjct: 126 RGWVRGLYKYLGDRIDIPAPDVNTNGQIMSWFVDEYVKLNGERMD-IGTFTGKPVAFGGS 184
Query: 185 LGRNEATARGASYTIREAAKVLGWDDLKGKTIAIQGYGNAGYYLAKIMSEDYGMKVVAV- 243
GRNEAT G + +RE+AK G ++ IA+QG+GN G + K + E G KV A+
Sbjct: 185 EGRNEATGFGVAVVVRESAKRFG-IKMEDAKIAVQGFGNVGTFTVKNI-ERQGGKVCAIA 242
Query: 244 ----SDSKGGIYNPDGLNADEVLKWKREHGSVKDFPGATNITNEELLELEVDVLAPAAIE 299
++ +YN +G++ E+L +K + ++ FPGA IT+EE E D++ PAA+E
Sbjct: 243 EWDRNEGNYALYNENGIDFKELLAYKEANKTLIGFPGAERITDEEFWTKEYDIIVPAALE 302
Query: 300 EVITKKNADNIKAKIVAEVANGPVTPEADEILFEKGILQIPDFLCNAGGVTVSYFEWVQN 359
VIT + A I AK+V E ANGP TPE D++L E+GI PD L N+GGV VSY+EWVQN
Sbjct: 303 NVITGERAKTINAKLVCEAANGPTTPEGDKVLTERGINLTPDILTNSGGVLVSYYEWVQN 362
Query: 360 ITGYYWTLEEVREKLDKKMTKAFYDVYNTAKEKNIHMRDAAYVVAVQRVYQAMLDRGW 417
GYYWT EV EK + M KA V+ A E N+ +R+A Y+ A++ + AM RGW
Sbjct: 363 QYGYYWTEAEVEEKQEADMMKAIKGVFAVADEYNVTLREAVYMYAIKSIDVAMKLRGW 420
>sp|P29051|DHE4_HALSA NADP-SPECIFIC GLUTAMATE DEHYDROGENASE (NADP-GDH)
>gi|99214|pir||S18609 glutamate dehydrogenase (NADP+)
(EC 1.4.1.4) - Halobacterium salinarum
>gi|49046|emb|CAA45327.1| (X63837) NADP-dependent
glutamate dehydrogenase [Halobacterium salinarum]
Length = 435
Score = 374 bits (951), Expect = e-103
Identities = 194/413 (46%), Positives = 268/413 (63%), Gaps = 5/413 (1%)
Query: 4 QDPFEIAVKQLERAAQYMKISEEALEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQYNW 63
+ E A +QL AA Y+ I + +E LK P+++ EVTIP+E DDG+V+VFTG+R Q++
Sbjct: 25 ESALETARRQLYHAASYLDIDQNIVERLKYPKKVHEVTIPIERDDGTVEVFTGYRAQHDS 84
Query: 64 ARGPTKGGIRWHPEETLSTVKALAAWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREKERL 123
RGP KGG+R+HP+ T L WMTWK AVMDLP+GG KGG+ V+PK+LS EKERL
Sbjct: 85 VRGPYKGGLRYHPDVTRDECVGLGMWMTWKCAVMDLPFGGAKGGVAVNPKELSPEEKERL 144
Query: 124 ARGYIRAIYDVISPYEDIPAPDVYTNPQIMAWMMDEYETIARRKTPAFGIITGKPLSIGG 183
R + + I DVI P +DIPAPD+ T+PQ MAW+MD Y TP G++TGKP +GG
Sbjct: 145 TRRFTQEIRDVIGPNQDIPAPDMGTDPQTMAWLMDAYSMQEGETTP--GVVTGKPPVVGG 202
Query: 184 SLGRNEATARGASYTIREAAKVLGWDDLKGKTIAIQGYGNAGYYLAKIMSEDYGMKVVAV 243
S GR EA R + + + L T+A+QGYG+ G A+++ + +G +VA+
Sbjct: 203 SEGREEAPGRSVAIITQLVCEYYD-QPLDETTVAVQGYGSVGANAARLL-DKWGATIVAI 260
Query: 244 SDSKGGIYNPDGLNADEVLKWKREHGSVKDFPGATNITNEELLELEVDVLAPAAIEEVIT 303
SD G +Y PDG++ V E +V + T I+NEELL L+VDVL PAA+ VIT
Sbjct: 261 SDVNGAMYEPDGIDTASVPSHDEEPEAVTTY-ADTVISNEELLTLDVDVLIPAALGNVIT 319
Query: 304 KKNADNIKAKIVAEVANGPVTPEADEILFEKGILQIPDFLCNAGGVTVSYFEWVQNITGY 363
K+NA+ I A +V E ANGP T AD IL ++ + IPD L NAGGVTVSYFEW+Q+I
Sbjct: 320 KENAEAIAADLVVEGANGPTTSTADSILADRDVAVIPDILANAGGVTVSYFEWLQDINRR 379
Query: 364 YWTLEEVREKLDKKMTKAFYDVYNTAKEKNIHMRDAAYVVAVQRVYQAMLDRG 416
W+LE V ++L+ +M A+ V + + +++ RDAAY+VA+ R+ +A RG
Sbjct: 380 AWSLERVNDELEAEMQAAWRAVKDEYENRDVTWRDAAYIVALSRIAEAHEARG 432
>gb|AAG18779.1| (AE004982) glutamate dehydrogenase; GdhB [Halobacterium sp. NRC-1]
Length = 429
Score = 363 bits (923), Expect = 2e-99
Identities = 190/409 (46%), Positives = 260/409 (63%), Gaps = 4/409 (0%)
Query: 8 EIAVKQLERAAQYMKISEEALEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQYNWARGP 67
E A +QL+ AA+++ I++ +E L P R+V+V++PVE DDG+V V+ G+R Q++ RGP
Sbjct: 22 ETARRQLQAAAEHVDIADGVIERLTHPTRVVQVSVPVERDDGTVTVYDGYRAQHDDVRGP 81
Query: 68 TKGGIRWHPEETLSTVKALAAWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREKERLARGY 127
KGG+R+HP + L+ WMTWK AVMDLP+GG KGG++VDPK LS E ERL R +
Sbjct: 82 YKGGLRYHPGVSAEECVGLSMWMTWKCAVMDLPFGGAKGGVVVDPKTLSADEHERLTRRF 141
Query: 128 IRAIYDVISPYEDIPAPDVYTNPQIMAWMMDEYETIARRKTPAFGIITGKPLSIGGSLGR 187
+ D + P +DIPAPD+ T+ Q MAW MD Y P G++TGKP GGS GR
Sbjct: 142 AAELRDEVGPSQDIPAPDMGTDAQTMAWFMDAYSMQQGETVP--GVVTGKPPVAGGSHGR 199
Query: 188 NEATARGASYTIREAAKVLGWDDLKGKTIAIQGYGNAGYYLAKIMSEDYGMKVVAVSDSK 247
EA R + REA + T+A+QGYG+ G A ++ +D+G +VVAVSD
Sbjct: 200 AEAPGRSVAIATREAINYYDIP-IDDATVAVQGYGSVGANAALLL-DDWGARVVAVSDVN 257
Query: 248 GGIYNPDGLNADEVLKWKREHGSVKDFPGATNITNEELLELEVDVLAPAAIEEVITKKNA 307
GG+ + DGL+ + + +V +TNEELLEL+VDV+ PAA+ VIT NA
Sbjct: 258 GGVLDTDGLDTHAIPSHGNQPAAVMRHDAPNTLTNEELLELDVDVVIPAAVGNVITAANA 317
Query: 308 DNIKAKIVAEVANGPVTPEADEILFEKGILQIPDFLCNAGGVTVSYFEWVQNITGYYWTL 367
D I+A IV E ANGP T AD IL E+ + IPD L NAGGVTVSYFEW+Q+I W+
Sbjct: 318 DRIQADIVVEGANGPTTSAADRILEERAVPVIPDILANAGGVTVSYFEWLQDINRRTWSP 377
Query: 368 EEVREKLDKKMTKAFYDVYNTAKEKNIHMRDAAYVVAVQRVYQAMLDRG 416
E VR++L+ +M A+ V + + ++ RDAAYVVA+QR+ +A RG
Sbjct: 378 ERVRDELESEMLSAWNAVRSEVDDGDLSWRDAAYVVALQRIGRAKEARG 426
>pir||T16981 glutamate dehydrogenase (EC 1.4.1.2) - curled-leaved tobacco
>gi|2196878|emb|CAA69600.1| (Y08292) NADH glutamate
dehydrogenase [Nicotiana plumbaginifolia]
>gi|8648954|emb|CAB94836.1| (AJ277949) NADH glutamate
dehydrogenase [Nicotiana plumbaginifolia]
Length = 411
Score = 362 bits (920), Expect = 4e-99
Identities = 192/406 (47%), Positives = 257/406 (63%), Gaps = 5/406 (1%)
Query: 12 KQLERAAQYMKISEEALEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQYNWARGPTKGG 71
+ +AA+ + + + + L P R ++V + DDG++ + GFRVQ++ ARGP KGG
Sbjct: 9 RNFRQAARILGLDSKLEKSLLIPFREIKVECTIPKDDGTLVSYVGFRVQHDNARGPMKGG 68
Query: 72 IRWHPEETLSTVKALAAWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREKERLARGYIRAI 131
IR+HPE L V ALA MTWKTAV D+PYGG KGGI PK LS E ERL R + + I
Sbjct: 69 IRYHPEVDLDEVNALAQLMTWKTAVADIPYGGAKGGIGCKPKDLSKSELERLTRVFTQKI 128
Query: 132 YDVISPYEDIPAPDVYTNPQIMAWMMDEYETIARRKTPAFGIITGKPLSIGGSLGRNEAT 191
+D+I D+PAPD+ TN Q MAW++DEY +PA I+TGKP+ +GGSLGR AT
Sbjct: 129 HDLIGINTDVPAPDMGTNAQTMAWILDEYSKF-HGHSPA--IVTGKPIDLGGSLGREAAT 185
Query: 192 ARGASYTIREAAKVLGWDDLKGKTIAIQGYGNAGYYLAKIMSEDYGMKVVAVSDSKGGIY 251
RG Y G ++K T AIQG+GN G + AK++ E G KV+AVSD G +
Sbjct: 186 GRGVVYATEALLAEYG-KNIKDLTFAIQGFGNVGAWAAKLIHERGG-KVIAVSDITGAVK 243
Query: 252 NPDGLNADEVLKWKREHGSVKDFPGATNITNEELLELEVDVLAPAAIEEVITKKNADNIK 311
NP+GL+ +L K G + DF G + ++E+L E DVL P A+ V+ ++NADN+K
Sbjct: 244 NPNGLDIPALLNHKEATGKLIDFSGGDVMNSDEVLTHECDVLIPCALGGVLNRENADNVK 303
Query: 312 AKIVAEVANGPVTPEADEILFEKGILQIPDFLCNAGGVTVSYFEWVQNITGYYWTLEEVR 371
AK + E AN P PEADEIL +KGI+ +PD NAGGVTVSYFEWVQNI G+ W E+V
Sbjct: 304 AKFIIEAANHPTDPEADEILCKKGIVILPDIYANAGGVTVSYFEWVQNIQGFMWDEEKVN 363
Query: 372 EKLDKKMTKAFYDVYNTAKEKNIHMRDAAYVVAVQRVYQAMLDRGW 417
+L K MTKAF+++ N + N +R A+ + V RV +A RGW
Sbjct: 364 RELRKYMTKAFHNLKNMCQSHNCSLRMGAFTLGVNRVARATTLRGW 409
>gb|AAG19574.1| (AE005047) glutamate dehydrogenase; GdhA2 [Halobacterium sp. NRC-1]
Length = 416
Score = 360 bits (913), Expect = 2e-98
Identities = 190/417 (45%), Positives = 265/417 (62%), Gaps = 5/417 (1%)
Query: 1 MVEQDPFEIAVKQLERAAQYMKISEEALEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQ 60
M E P E + Q+E+A +Y+ I + E LK P+R + V++PV MDDGSV+VF +R Q
Sbjct: 1 MTESGPLENMLAQMEQAREYVDIDDGIYERLKSPERTLSVSLPVRMDDGSVEVFDAYRCQ 60
Query: 61 YNWARGPTKGGIRWHPEETLSTVKALAAWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREK 120
++ ARGP KGGIR+HP + V ALA WMTWKTA++DLP+GG KGGI+ +PK+LSD E
Sbjct: 61 FDSARGPYKGGIRYHPTVSEEEVSALAGWMTWKTALVDLPFGGAKGGIVCNPKELSDNEI 120
Query: 121 ERLARGYIRAIYDVISPYEDIPAPDVYTNPQIMAWMMDEYETIARRKTPAFGIITGKPLS 180
E+L R Y I +I P DIPAPD+ T+P+ MAW+MD Y P ++TGKP
Sbjct: 121 EQLTRRYTEGIRRMIGPETDIPAPDMNTDPRTMAWVMDTYSVYQGYAVPE--VVTGKPPE 178
Query: 181 IGGSLGRNEATARGASYTIREAAKVLGWDDLKGKTIAIQGYGNAGYYLAKIMSEDYGMKV 240
IGG+ GR EAT RG S E + D++ +AIQG+GN G A ++SE G +
Sbjct: 179 IGGTDGRVEATGRGVSIITEETFEYFD-TDIQDADVAIQGFGNVGSVTADLLSE-RGANI 236
Query: 241 VAVSDSKGGIYNPDGLNADEVLKWKREHGSVKDFPGATNITNEELLELEVDVLAPAAIEE 300
VAVSD G I++P GL+ +V + +G + A I+N++LL L+VD L PAAIE+
Sbjct: 237 VAVSDVTGAIHDPTGLDIADVQAYADANGGRLEGYDAEPISNDDLLTLDVDALIPAAIED 296
Query: 301 VITKKNADNIKAKIVAEVANGPVTPEADEILFEKGILQIPDFLCNAGGVTVSYFEWVQNI 360
VIT A+ + A ++ E ANGP T +A ++L ++G+ +PD L NAGGV VSY EWVQN
Sbjct: 297 VITVDVAERLAADVIVEAANGPTTFDAAQVLSDRGVPVVPDILANAGGVIVSYLEWVQNS 356
Query: 361 TGYYWTLEEVREKLDKKMTKAFYDVYNTAKEKNI-HMRDAAYVVAVQRVYQAMLDRG 416
Y W +EEV L +++T AF ++ +++NI +R AAY +A++R A RG
Sbjct: 357 QQYSWDVEEVNRDLRQRLTGAFDEMLVAYEDRNIPTLRTAAYTIALERSADAHEFRG 413
>gb|AAA72385.1| (L19115) glutamate dehydrogenase [hyperthermophilic archaeon G1-H]
Length = 176
Score = 357 bits (906), Expect = 2e-97
Identities = 171/176 (97%), Positives = 174/176 (98%)
Query: 100 PYGGGKGGIIVDPKKLSDREKERLARGYIRAIYDVISPYEDIPAPDVYTNPQIMAWMMDE 159
PYGGGKGGIIVDPKKLSDREKERLARGYIRAIYDVISPYEDIPAPDVYTNPQIMAWMMDE
Sbjct: 1 PYGGGKGGIIVDPKKLSDREKERLARGYIRAIYDVISPYEDIPAPDVYTNPQIMAWMMDE 60
Query: 160 YETIARRKTPAFGIITGKPLSIGGSLGRNEATARGASYTIREAAKVLGWDDLKGKTIAIQ 219
YE I+RRKTPAFGIITGKPLSIGGSLGRNEATARGASYTIREAAKVLGW DLKGKTIAIQ
Sbjct: 61 YEAISRRKTPAFGIITGKPLSIGGSLGRNEATARGASYTIREAAKVLGWGDLKGKTIAIQ 120
Query: 220 GYGNAGYYLAKIMSEDYGMKVVAVSDSKGGIYNPDGLNADEVLKWKREHGSVKDFP 275
GYGNAGYYLAKIMSEDYGMKVVAVSD+KGGIYNPDGLNADEVLKWK+EHGSVKDFP
Sbjct: 121 GYGNAGYYLAKIMSEDYGMKVVAVSDTKGGIYNPDGLNADEVLKWKQEHGSVKDFP 176
>sp|P52596|DHE3_VITVI GLUTAMATE DEHYDROGENASE (GDH) >gi|1085815|pir||S54797 glutamate
dehydrogenase (NAD(P)+) (EC 1.4.1.3) - grape
>gi|806595|emb|CAA60507.1| (X86924) glutamate
dehydrogenase [Vitis vinifera]
Length = 411
Score = 353 bits (895), Expect = 3e-96
Identities = 186/406 (45%), Positives = 257/406 (62%), Gaps = 5/406 (1%)
Query: 12 KQLERAAQYMKISEEALEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQYNWARGPTKGG 71
+ A++ + + + + L P R ++V + DDGS+ + GFRVQ++ ARGP KGG
Sbjct: 9 RNFRHASRILGLDSKLEKSLLIPFREIKVECTIPKDDGSLATYVGFRVQHDNARGPMKGG 68
Query: 72 IRWHPEETLSTVKALAAWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREKERLARGYIRAI 131
IR+HPE V ALA MTWKTAV+D+PYGG KGGI PK LS E ERL R + + I
Sbjct: 69 IRYHPEVDPDEVNALAQLMTWKTAVVDIPYGGAKGGIGCTPKDLSMSELERLTRVFTQKI 128
Query: 132 YDVISPYEDIPAPDVYTNPQIMAWMMDEYETIARRKTPAFGIITGKPLSIGGSLGRNEAT 191
+D+I + D+PAPD+ TN Q MAW++DEY +PA ++TGKP+++GGSLGR AT
Sbjct: 129 HDLIGTHTDVPAPDMGTNAQTMAWILDEYSKF-HGHSPA--VVTGKPIALGGSLGREAAT 185
Query: 192 ARGASYTIREAAKVLGWDDLKGKTIAIQGYGNAGYYLAKIMSEDYGMKVVAVSDSKGGIY 251
RG + EA +KG T IQG+GN G ++A+++ E G K++AVSD G +
Sbjct: 186 GRGVVFAT-EALLAQHGKSIKGLTFVIQGFGNVGSWVARLIGERGG-KIIAVSDVTGAVK 243
Query: 252 NPDGLNADEVLKWKREHGSVKDFPGATNITNEELLELEVDVLAPAAIEEVITKKNADNIK 311
N +GL+ ++L+ K E G + +F G ++ ELL E DVL P A+ V+ K+NA ++K
Sbjct: 244 NQNGLDIVDLLRHKEETGCLTNFSGGDHMDPNELLTHECDVLIPCALGGVLNKENAADVK 303
Query: 312 AKIVAEVANGPVTPEADEILFEKGILQIPDFLCNAGGVTVSYFEWVQNITGYYWTLEEVR 371
AK + E AN P PEADEIL +KG + +PD NAGGVTVSYFEWVQNI G+ W E+V
Sbjct: 304 AKFIIEAANHPTDPEADEILSKKGGVILPDIYANAGGVTVSYFEWVQNIQGFMWEEEKVN 363
Query: 372 EKLDKKMTKAFYDVYNTAKEKNIHMRDAAYVVAVQRVYQAMLDRGW 417
+L K MTKAF+++ + N +R A+ +AV RV A RGW
Sbjct: 364 NELQKYMTKAFHNIKAMCQSHNCSLRMGAFTLAVNRVACATTLRGW 409
>pir||S71217 glutamate dehydrogenase (EC 1.4.1.-) 1 - Arabidopsis thaliana
>gi|1098960|gb|AAA82615.1| (U37771) glutamate
dehydrogenase 1 [Arabidopsis thaliana]
>gi|1293095|gb|AAB08057.1| (U53527) glutamate
dehydrogenase 1 [Arabidopsis thaliana]
>gi|9758899|dbj|BAB09475.1| (AB012246) glutamate
dehydrogenase (EC 1.4.1.-) 1 [Arabidopsis thaliana]
Length = 411
Score = 353 bits (895), Expect = 3e-96
Identities = 186/406 (45%), Positives = 255/406 (61%), Gaps = 5/406 (1%)
Query: 12 KQLERAAQYMKISEEALEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQYNWARGPTKGG 71
+ + AA+ + + + + L P R ++V + DDG++ F GFRVQ++ ARGP KGG
Sbjct: 9 RNFKLAARLLGLDSKLEKSLLIPFREIKVECTIPKDDGTLASFVGFRVQHDNARGPMKGG 68
Query: 72 IRWHPEETLSTVKALAAWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREKERLARGYIRAI 131
IR+HPE V ALA MTWKTAV +PYGG KGGI DP KLS E ERL R + + I
Sbjct: 69 IRYHPEVDPDEVNALAQLMTWKTAVAKIPYGGAKGGIGCDPSKLSISELERLTRVFTQKI 128
Query: 132 YDVISPYEDIPAPDVYTNPQIMAWMMDEYETIARRKTPAFGIITGKPLSIGGSLGRNEAT 191
+D+I + D+PAPD+ T PQ MAW++DEY +PA ++TGKP+ +GGSLGR+ AT
Sbjct: 129 HDLIGIHTDVPAPDMGTGPQTMAWILDEYSKF-HGYSPA--VVTGKPIDLGGSLGRDAAT 185
Query: 192 ARGASYTIREAAKVLGWDDLKGKTIAIQGYGNAGYYLAKIMSEDYGMKVVAVSDSKGGIY 251
RG + G + G+ IQG+GN G + AK++SE G K+VAVSD G I
Sbjct: 186 GRGVMFGTEALLNEHG-KTISGQRFVIQGFGNVGSWAAKLISEKGG-KIVAVSDITGAIK 243
Query: 252 NPDGLNADEVLKWKREHGSVKDFPGATNITNEELLELEVDVLAPAAIEEVITKKNADNIK 311
N DG++ +LK +EH VK F GA I +L + D+L PAA+ VI ++NA+ IK
Sbjct: 244 NKDGIDIPALLKHTKEHRGVKGFDGADPIDPNSILVEDCDILVPAALGGVINRENANEIK 303
Query: 312 AKIVAEVANGPVTPEADEILFEKGILQIPDFLCNAGGVTVSYFEWVQNITGYYWTLEEVR 371
AK + E AN P P+ADEIL +KG++ +PD N+GGVTVSYFEWVQNI G+ W E+V
Sbjct: 304 AKFIIEAANHPTDPDADEILSKKGVVILPDIYANSGGVTVSYFEWVQNIQGFMWEEEKVN 363
Query: 372 EKLDKKMTKAFYDVYNTAKEKNIHMRDAAYVVAVQRVYQAMLDRGW 417
++L MT++F D+ K + +R A+ + V RV QA + RGW
Sbjct: 364 DELKTYMTRSFKDLKEMCKTHSCDLRMGAFTLGVNRVAQATILRGW 409
>gb|AAG19131.1| (AE005011) glutamate dehydrogenase; GdhA1 [Halobacterium sp. NRC-1]
Length = 372
Score = 350 bits (888), Expect = 2e-95
Identities = 187/369 (50%), Positives = 242/369 (64%), Gaps = 8/369 (2%)
Query: 46 MDDGSVKVFTGFRVQYNWARGPTKGGIRWHPEETLSTVKALAAWMTWKTAVMDLPYGGGK 105
MDDG+++ F FR Q+N RGP KGGIR+HP T VKAL+ WM +KTAV D+PYGGGK
Sbjct: 1 MDDGTIETFKAFRSQFNGDRGPYKGGIRYHPGVTRDEVKALSGWMVYKTAVADIPYGGGK 60
Query: 106 GGIIVDPKKLSDREKERLARGYIRAIYDVISPYEDIPAPDVYTNPQIMAWMMDEYETIAR 165
GGII+DP++ SD E ER+ R + + I +D+PAPDV T + M W+ D YET+
Sbjct: 61 GGIILDPEEYSDSELERITRAFATELRPFIGEDKDVPAPDVNTGQREMNWIKDTYETL-- 118
Query: 166 RKTPAFGIITGKPLSIGGSLGRNEATARGASYTIREAAKVLGWDDLKGKTIAIQGYGNAG 225
T A G+ITGK L GGS GR AT R + RE L DL T+A+QGYGNAG
Sbjct: 119 EDTTAPGVITGKALENGGSEGRVNATGRSTMFAAREVFDYLD-RDLSDATVAVQGYGNAG 177
Query: 226 YYLAKIMSEDYGMKVVAVSDSKGGIYNPDGLNADEVLKWKREHGSVKDFPGAT-NITNEE 284
AK+++ D G VVAVSDS G ++NPDGL+ V +K E GSV + GAT ++NE
Sbjct: 178 SVAAKLIA-DQGADVVAVSDSSGAVHNPDGLDTRAVKAFKTETGSVSGYEGATEELSNEA 236
Query: 285 LLELEVDVLAPAAIEEVITKKNADNIKAKIVAEVANGPVTPEADEILFEKGILQIPDFLC 344
LL ++VD+L PAA+E I + A ++ A +V E ANGP+TP+AD++L E+G+ +PD L
Sbjct: 237 LLTMDVDLLVPAALENAIDEDLAHDVDADVVVEAANGPLTPDADDVLTERGVTVVPDILA 296
Query: 345 NAGGVTVSYFEWVQNITGYYWTLEEVREKLDKKMTKAFYDVYNTAKEK--NIHMRDAAYV 402
NAGGVTVSYFEWVQN + WT + V E+L+ +T AF D A E ++R AAYV
Sbjct: 297 NAGGVTVSYFEWVQNRQRFQWTEDRVNEELEAIITDAF-DAMTDAHEDAGTPNLRTAAYV 355
Query: 403 VAVQRVYQA 411
VAVQRV A
Sbjct: 356 VAVQRVVDA 364
>pir||T49883 glutamate dehydrogenase 2 - Arabidopsis thaliana
>gi|1336084|gb|AAB01222.1| (U56635) glutamate
dehydrogenase 2 [Arabidopsis thaliana]
>gi|7576182|emb|CAB87933.1| (AL163912) glutamate
dehydrogenase 2 [Arabidopsis thaliana]
Length = 411
Score = 349 bits (887), Expect = 3e-95
Identities = 183/406 (45%), Positives = 255/406 (62%), Gaps = 5/406 (1%)
Query: 12 KQLERAAQYMKISEEALEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQYNWARGPTKGG 71
+ A++ + + + L P R ++V + DDG++ + GFRVQ++ ARGP KGG
Sbjct: 9 RNFRHASRILGLDSKIERSLMIPFREIKVECTIPKDDGTLVSYIGFRVQHDNARGPMKGG 68
Query: 72 IRWHPEETLSTVKALAAWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREKERLARGYIRAI 131
IR+HPE V ALA MTWKTAV D+PYGG KGGI P+ LS E ERL R + + I
Sbjct: 69 IRYHPEVDPDEVNALAQLMTWKTAVADIPYGGAKGGIGCSPRDLSLSELERLTRVFTQKI 128
Query: 132 YDVISPYEDIPAPDVYTNPQIMAWMMDEYETIARRKTPAFGIITGKPLSIGGSLGRNEAT 191
+D+I + D+PAPD+ TN Q MAW++DEY +PA ++TGKP+ +GGSLGR AT
Sbjct: 129 HDLIGIHTDVPAPDMGTNAQTMAWILDEYSKF-HGHSPA--VVTGKPIDLGGSLGREAAT 185
Query: 192 ARGASYTIREAAKVLGWDDLKGKTIAIQGYGNAGYYLAKIMSEDYGMKVVAVSDSKGGIY 251
RG + G ++G T IQG+GN G + AK++ E G KVVAVSD G I
Sbjct: 186 GRGVVFATEALLAEYG-KSIQGLTFVIQGFGNVGTWAAKLIHEKGG-KVVAVSDITGAIR 243
Query: 252 NPDGLNADEVLKWKREHGSVKDFPGATNITNEELLELEVDVLAPAAIEEVITKKNADNIK 311
NP+G++ + ++K K GS+ DF G + ++ELL E DVL P A+ V+ K+NA ++K
Sbjct: 244 NPEGIDINALIKHKDATGSLNDFNGGDAMNSDELLIHECDVLIPCALGGVLNKENAGDVK 303
Query: 312 AKIVAEVANGPVTPEADEILFEKGILQIPDFLCNAGGVTVSYFEWVQNITGYYWTLEEVR 371
AK + E AN P P+ADEIL +KG++ +PD NAGGVTVSYFEWVQNI G+ W E+V
Sbjct: 304 AKFIVEAANHPTDPDADEILSKKGVIILPDIYANAGGVTVSYFEWVQNIQGFMWEEEKVN 363
Query: 372 EKLDKKMTKAFYDVYNTAKEKNIHMRDAAYVVAVQRVYQAMLDRGW 417
+L K MT+AF+++ + ++R A+ + V RV +A RGW
Sbjct: 364 LELQKYMTRAFHNIKTMCHTHSCNLRMGAFTLGVNRVARATQLRGW 409
>gb|AAK42230.1| NAD specific glutamate dehydrogenase (gdhA-4) [Sulfolobus
solfataricus]
Length = 420
Score = 346 bits (878), Expect = 3e-94
Identities = 187/410 (45%), Positives = 263/410 (63%), Gaps = 10/410 (2%)
Query: 11 VKQLERAAQYMKISEEALEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQYNWARGPTKG 70
VK+L + + + + E LE L +P+RI++V I + DG +K F G+R Q+N A GP KG
Sbjct: 15 VKKLYKVGELLGLDNETLETLSQPERIIQVKIQIRGSDGKLKTFMGWRSQHNSALGPYKG 74
Query: 71 GIRWHPEETLSTVKALAAWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREKERLARGYIRA 130
GIR+HP T V+AL+ MTWK +++ LPYGGGKGGI VDPKKL+ E E+L+R +I+A
Sbjct: 75 GIRYHPNVTQDEVEALSMIMTWKNSLLLLPYGGGKGGIRVDPKKLTKEELEQLSRKFIQA 134
Query: 131 IYDVISPYEDIPAPDVYTNPQIMAWMMDEYETIARRKTPAFGIITGKPLSIGGSLGRNEA 190
IY + DIPAPDV T+ Q MAW +DEY I F + TGKP+ +GG R +
Sbjct: 135 IYKYLGSELDIPAPDVNTDSQTMAWYLDEYIKITGNVD--FAVFTGKPVELGGIGVRLYS 192
Query: 191 TARGASYTIREAA-KVLGWDDLKGKTIAIQGYGNAGYYLAKIMSEDYGMKVVAVSDSKGG 249
T G + +EAA K +G ++ + IQG+GN GYY AK +S D G K+V +SDSKGG
Sbjct: 193 TGLGVATIAKEAANKFIG--GIEEARVIIQGFGNVGYYAAKFLS-DMGAKIVGISDSKGG 249
Query: 250 IYNPDGLNADEVLKWKREHGSVKDFPGATNITNEELLELEVDVLAPAAIEEVITKKNADN 309
+ N +G++ + ++ K + GSV ++P +TNEELL + ++L PAA+E VI K NA
Sbjct: 250 VINENGIDVGKAMEIKEKTGSVTNYPEGRKVTNEELLISDCNILVPAALENVINKFNAPK 309
Query: 310 IKAKIVAEVANGPVTPEADEILFEKGILQIPDFLCNAGGVTVSYFEWVQNITGYYWTLEE 369
IKAK++ E ANGP+T +ADEI+ ++GI+ +PD L NAGGV SY EW N G + EE
Sbjct: 310 IKAKLIVEGANGPLTADADEIMRQRGIVVVPDILANAGGVVGSYVEWANNKMGQIISDEE 369
Query: 370 VREKLDKKMTKAF---YDVYNTAKEKNIHMRDAAYVVAVQRVYQAMLDRG 416
++ + +M AF YD Y+ K ++ +R AA +AV RV +AM RG
Sbjct: 370 AKKLIVDRMNNAFNTLYD-YHQKKLEDHDLRTAAMALAVDRVVRAMKARG 418
>pir||T43790 probable glutamate dehydrogenase [imported] - Pyrobaculum
islandicum >gi|4850373|dbj|BAA77715.1| (AB027194)
glutamate dehydrogenase [Pyrobaculum islandicum]
Length = 421
Score = 345 bits (875), Expect = 7e-94
Identities = 193/420 (45%), Positives = 256/420 (60%), Gaps = 15/420 (3%)
Query: 8 EIAVKQLERAAQYMKISEEALEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQYNWARGP 67
E + +++ + E+ + L RP+R++ V IPV +D G +VF G+RVQ+ GP
Sbjct: 8 EYVLNYVKKGVELGGFPEDFYKILSRPRRVLIVNIPVRLDGGGFEVFEGYRVQHCDVLGP 67
Query: 68 TKGGIRWHPEETLSTVKALAAWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREKERLARGY 127
KGG+R+HPE TL+ ALA MT K ++ LPYGG KG + VDPKKLS RE E L+RGY
Sbjct: 68 YKGGVRFHPEVTLADDVALAILMTLKNSLAGLPYGGAKGAVRVDPKKLSQRELEELSRGY 127
Query: 128 IRAIYDVISPYEDIPAPDVYTNPQIMAWMMDEYETIARRKTPAFGIITGKPLSIGGSLGR 187
RAI +I DIPAPDV TN QIMAWM+DEY I P G+ T KP + G+ R
Sbjct: 128 ARAIAPLIGDVVDIPAPDVGTNAQIMAWMVDEYSKIKGYNVP--GVFTSKPPELWGNPVR 185
Query: 188 NEATARGASYTIREAAKVLGWDDLKGKTIAIQGYGNAGYYLAKIMSEDYGMKVVAVSDSK 247
AT G + RE AK L W ++GKT+AIQG GN G + A + E G KV+AVSD
Sbjct: 186 EYATGFGVAVATREMAKKL-WGGIEGKTVAIQGMGNVGRWTAYWL-EKMGAKVIAVSDIN 243
Query: 248 GGIYNPDGLNADEVLKWKREHG-------SVKDFPGATNITN-EELLELEVDVLAPAAIE 299
G Y +GLN + + K K G + KD A + N + + +L+VD+ PAAIE
Sbjct: 244 GVAYRKEGLNVELIQKNKGLTGPALVELFTTKD--NAEFVKNPDAIFKLDVDIFVPAAIE 301
Query: 300 EVITKKNADNIKAKIVAEVANGPVTPEADEILFEKGILQIPDFLCNAGGVTVSYFEWVQN 359
VI NA +KA++V E ANGP TPEA+ IL+E+G++ +PD L NAGGV +SY EWV+N
Sbjct: 302 NVIRGDNAGLVKARLVVEGANGPTTPEAERILYERGVVVVPDILANAGGVIMSYLEWVEN 361
Query: 360 ITGYYWTLEEVREKLDKKMTKAFYDVYNT-AKEKNIHMRDAAYVVAVQRVYQAMLDRGWV 418
+ Y W EE R++L+ M VY +EK MRDAA V A++R+Y AM RGW+
Sbjct: 362 LQWYIWDEEETRKRLENIMVNNVERVYKRWQREKGWTMRDAAIVTALERIYNAMKIRGWI 421
>gb|AAK42099.1| NAD specific glutamate dehydrogenase (gdhA-2) [Sulfolobus
solfataricus]
Length = 420
Score = 344 bits (873), Expect = 1e-93
Identities = 186/410 (45%), Positives = 261/410 (63%), Gaps = 10/410 (2%)
Query: 11 VKQLERAAQYMKISEEALEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQYNWARGPTKG 70
VK+L + + + + E LE L +P+RI++V I + DG +K F G+R Q+N A GP KG
Sbjct: 15 VKKLYKVGELLGLDNETLETLSQPERIIQVKIQIRGSDGKLKTFMGWRSQHNSALGPYKG 74
Query: 71 GIRWHPEETLSTVKALAAWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREKERLARGYIRA 130
G+R+HP T V+AL+ MTWK +++ LPYGGGKGG+ VDPKKL+ E E+L+R YI+A
Sbjct: 75 GVRYHPNVTQDEVEALSMIMTWKNSLLLLPYGGGKGGVRVDPKKLTREELEQLSRKYIQA 134
Query: 131 IYDVISPYEDIPAPDVYTNPQIMAWMMDEYETIARRKTPAFGIITGKPLSIGGSLGRNEA 190
IY + DIPAPDV T+ Q MAW +DEY I + F + TGKP+ +GG R +
Sbjct: 135 IYKYLGSELDIPAPDVNTDSQTMAWFLDEYIKITGKVD--FAVFTGKPVELGGIGVRLYS 192
Query: 191 TARGASYTIREAA-KVLGWDDLKGKTIAIQGYGNAGYYLAKIMSEDYGMKVVAVSDSKGG 249
T G + +EAA K +G ++ + IQG+GN GYY K +SE G K+V VSDSKGG
Sbjct: 193 TGLGVATIAKEAANKFIG--GVEEARVIIQGFGNVGYYAGKFLSE-MGAKIVGVSDSKGG 249
Query: 250 IYNPDGLNADEVLKWKREHGSVKDFPGATNITNEELLELEVDVLAPAAIEEVITKKNADN 309
+ N G++ + ++ K + GSV ++P +TNEELL + D+L PAA+E VI K NA
Sbjct: 250 VINEKGIDVGKAIEIKEKTGSVINYPEGRKVTNEELLISDCDILIPAALENVINKFNAPK 309
Query: 310 IKAKIVAEVANGPVTPEADEILFEKGILQIPDFLCNAGGVTVSYFEWVQNITGYYWTLEE 369
+KAK++ E ANGP+T +ADEI+ ++GI +PD L NAGGV SY EW N G + EE
Sbjct: 310 VKAKLIVEGANGPLTADADEIMRQRGIAVVPDILANAGGVVGSYVEWANNKMGEIISDEE 369
Query: 370 VREKLDKKMTKAF---YDVYNTAKEKNIHMRDAAYVVAVQRVYQAMLDRG 416
++ + +M AF YD Y+ K ++ +R AA +AV RV +AM RG
Sbjct: 370 AKKLIVDRMNNAFNTLYD-YHQKKLEDHDLRTAAMALAVDRVVRAMKARG 418
>sp|P80053|DHE3_SULSO GLUTAMATE DEHYDROGENASE (GDH) >gi|478591|pir||S20286 glutamate
dehydrogenase (NAD(P)+) (EC 1.4.1.3) - Sulfolobus
solfataricus >gi|243120|gb|AAB21053.1| glutamate
dehydrogenase, GDH [Sulfolobus solfataricus, strain
MT-4, Peptide, 421 aa] >gi|228559|prf||1806206A Glu
dehydrogenase [Sulfolobus solfataricus]
Length = 421
Score = 344 bits (873), Expect = 1e-93
Identities = 182/409 (44%), Positives = 256/409 (62%), Gaps = 6/409 (1%)
Query: 11 VKQLERAAQYMKISEEALEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQYNWARGPTKG 70
VK+L + + + + E LE L +P+RI++V I + DG +K F G+R Q+N A GP KG
Sbjct: 14 VKKLYKVGELLGLDNETLETLSQPERIIQVKIQIRGSDGKLKTFMGWRSQHNSALGPYKG 73
Query: 71 GIRWHPEETLSTVKALAAWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREKERLARGYIRA 130
G+R+HP T V+AL+ MTWK +++ LPYGGGKGG+ VDPKKL+ E E+L+R YI+A
Sbjct: 74 GVRYHPNVTQDEVEALSMIMTWKNSLLLLPYGGGKGGVRVDPKKLTREELEQLSRKYIQA 133
Query: 131 IYDVISPYEDIPAPDVYTNPQIMAWMMDEYETIARRKTPAFGIITGKPLSIGGSLGRNEA 190
IY + DIPAPDV T+ Q MAW +DEY I + F + TGKP+ +GG R +
Sbjct: 134 IYKYLGSELDIPAPDVNTDSQTMAWFLDEYIKITGKVD--FAVFTGKPVELGGIGVRLYS 191
Query: 191 TARGASYTIREAAKVLGWDDLKGKTIAIQGYGNAGYYLAKIMSEDYGMKVVAVSDSKGGI 250
T G + +E A ++ + IQG+GN GYY K +SE G K+V VSDSKGG+
Sbjct: 192 TGLGVATIAKEEAANKFIGGVEEARVIIQGFGNVGYYAGKFLSE-MGAKIVGVSDSKGGV 250
Query: 251 YNPDGLNADEVLKWKREHGSVKDFPGATNITNEELLELEVDVLAPAAIEEVITKKNADNI 310
N G++ + ++ K + GSV ++P +TNEELL + D+L PAA+E VI K NA +
Sbjct: 251 INEKGIDVGKAIEIKEKTGSVINYPEGRKVTNEELLISDCDILIPAALENVINKFNAPKV 310
Query: 311 KAKIVAEVANGPVTPEADEILFEKGILQIPDFLCNAGGVTVSYFEWVQNITGYYWTLEEV 370
KAK++ E ANGP+T +ADEI+ ++GI +PD L NAGGV SY EW N G + EE
Sbjct: 311 KAKLIVEGANGPLTADADEIMRQRGIAVVPDILANAGGVVGSYVEWANNKMGEIISDEEA 370
Query: 371 REKLDKKMTKAF---YDVYNTAKEKNIHMRDAAYVVAVQRVYQAMLDRG 416
++ + +M AF YD + K ++ +R AA +AV RV +AM RG
Sbjct: 371 KKLIVDRMNNAFNTLYDYHQKKKLEDHDLRTAAMALAVDRVVRAMKARG 419
>emb|CAB94837.1| (AJ277950) NADH-glutamate dehydrogenase [Nicotiana plumbaginifolia]
Length = 411
Score = 343 bits (871), Expect = 2e-93
Identities = 182/406 (44%), Positives = 252/406 (61%), Gaps = 5/406 (1%)
Query: 12 KQLERAAQYMKISEEALEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQYNWARGPTKGG 71
+ + A++ + + + + L P R ++V + DDGS+ F GFRVQ++ ARGP KGG
Sbjct: 9 RNFKLASRLLGLDSKLEQCLLIPFREIKVECTIPKDDGSLATFIGFRVQHDNARGPMKGG 68
Query: 72 IRWHPEETLSTVKALAAWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREKERLARGYIRAI 131
IR+HPE V ALA MTWKTAV ++PYGG KGGI P LS E ERL R + + I
Sbjct: 69 IRYHPEVDPDEVNALAQLMTWKTAVANIPYGGAKGGIGCSPSDLSISELERLTRVFTQKI 128
Query: 132 YDVISPYEDIPAPDVYTNPQIMAWMMDEYETIARRKTPAFGIITGKPLSIGGSLGRNEAT 191
+D+I + D+PAPD+ TNPQ MAW++DEY +PA ++TGKP+ +GGSLGR+ AT
Sbjct: 129 HDLIGVHTDVPAPDMGTNPQTMAWILDEYSKF-HGYSPA--VVTGKPIDLGGSLGRDAAT 185
Query: 192 ARGASYTIREAAKVLGWDDLKGKTIAIQGYGNAGYYLAKIMSEDYGMKVVAVSDSKGGIY 251
RG + + G + G+ +QG+GN G + A++++E G K+VAVSD G I
Sbjct: 186 GRGVLFAAEALLRDHG-KSIAGQRFVVQGFGNVGSWAAQLITEQGG-KIVAVSDITGAIK 243
Query: 252 NPDGLNADEVLKWKREHGSVKDFPGATNITNEELLELEVDVLAPAAIEEVITKKNADNIK 311
N +G++ +LK +E+ VK F GA +I +L + DVL PAA+ VI + NA +IK
Sbjct: 244 NKNGIDIASLLKHVKENRGVKGFHGADSIDPNSILVEDCDVLIPAALGGVINRDNAKDIK 303
Query: 312 AKIVAEVANGPVTPEADEILFEKGILQIPDFLCNAGGVTVSYFEWVQNITGYYWTLEEVR 371
AK + E AN P PEADEIL +KG++ +PD N+GGVTVSYFEWVQNI G+ W E V
Sbjct: 304 AKFIVEAANHPTDPEADEILAKKGVVILPDIYANSGGVTVSYFEWVQNIQGFMWDEERVN 363
Query: 372 EKLDKKMTKAFYDVYNTAKEKNIHMRDAAYVVAVQRVYQAMLDRGW 417
+L M + F DV + K N +R A+ + V RV +A RGW
Sbjct: 364 TELKAYMNRGFKDVKDMCKTHNCDLRMGAFTLGVNRVARATTLRGW 409
>pir||T16982 glutamate dehydrogenase (EC 1.4.1.-) B - curled-leaved tobacco
>gi|4688955|emb|CAA69601.2| (Y08293) NADH glutamate
dehydrogenase [Nicotiana plumbaginifolia]
Length = 411
Score = 341 bits (866), Expect = 8e-93
Identities = 181/406 (44%), Positives = 251/406 (61%), Gaps = 5/406 (1%)
Query: 12 KQLERAAQYMKISEEALEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQYNWARGPTKGG 71
+ + A++ + + + + L P R ++V + DDGS+ F GFRVQ++ ARGP KGG
Sbjct: 9 RNFKLASRLLGLDSKLEQCLLIPFREIKVECTIPKDDGSLATFIGFRVQHDNARGPMKGG 68
Query: 72 IRWHPEETLSTVKALAAWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREKERLARGYIRAI 131
IR+HPE V ALA MTWKT V ++PYGG KGGI P LS E ERL R + + I
Sbjct: 69 IRYHPEVDPDEVNALAQLMTWKTRVANIPYGGAKGGIGCSPSDLSISELERLTRVFTQKI 128
Query: 132 YDVISPYEDIPAPDVYTNPQIMAWMMDEYETIARRKTPAFGIITGKPLSIGGSLGRNEAT 191
+D+I + D+PAPD+ TNPQ MAW++DEY +PA ++TGKP+ +GGSLGR+ AT
Sbjct: 129 HDLIGVHTDVPAPDMGTNPQTMAWILDEYSKF-HGYSPA--VVTGKPIDLGGSLGRDAAT 185
Query: 192 ARGASYTIREAAKVLGWDDLKGKTIAIQGYGNAGYYLAKIMSEDYGMKVVAVSDSKGGIY 251
RG + + G + G+ +QG+GN G + A++++E G K+VAVSD G I
Sbjct: 186 GRGVLFAAEALLRDHG-KSIAGQRFVVQGFGNVGSWAAQLITEQGG-KIVAVSDITGAIK 243
Query: 252 NPDGLNADEVLKWKREHGSVKDFPGATNITNEELLELEVDVLAPAAIEEVITKKNADNIK 311
N +G++ +LK +E+ VK F GA +I +L + DVL PAA+ VI + NA +IK
Sbjct: 244 NKNGIDIASLLKHVKENRGVKGFHGADSIDPNSILVEDCDVLIPAALGGVINRDNAKDIK 303
Query: 312 AKIVAEVANGPVTPEADEILFEKGILQIPDFLCNAGGVTVSYFEWVQNITGYYWTLEEVR 371
AK + E AN P PEADEIL +KG++ +PD N+GGVTVSYFEWVQNI G+ W E V
Sbjct: 304 AKFIVEAANHPTDPEADEILAKKGVVILPDIYANSGGVTVSYFEWVQNIQGFMWDEERVN 363
Query: 372 EKLDKKMTKAFYDVYNTAKEKNIHMRDAAYVVAVQRVYQAMLDRGW 417
+L M + F DV + K N +R A+ + V RV +A RGW
Sbjct: 364 TELKDYMNRGFKDVKDMCKTHNCDLRMGAFTLGVNRVARATTLRGW 409
>gb|AAF00627.1|AC009540_4 (AC009540) putative glutamate dehydrogenase [Arabidopsis thaliana]
>gi|6223637|gb|AAF05851.1|AC011698_2 (AC011698) putative
glutamate dehydrogenase [Arabidopsis thaliana]
Length = 411
Score = 341 bits (866), Expect = 8e-93
Identities = 180/406 (44%), Positives = 254/406 (62%), Gaps = 5/406 (1%)
Query: 12 KQLERAAQYMKISEEALEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQYNWARGPTKGG 71
+ + A++ + + + + L P R ++V + DDG++ F GFRVQ++ ARGP KGG
Sbjct: 9 RNFKLASRLLGLDSKLEKSLLIPFREIKVECTIPKDDGTLASFVGFRVQHDNARGPMKGG 68
Query: 72 IRWHPEETLSTVKALAAWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREKERLARGYIRAI 131
IR+HPE V ALA MTWKTAV +PYGG KGGI DP +LS E ERL R + + I
Sbjct: 69 IRYHPEVEPDEVNALAQLMTWKTAVAKIPYGGAKGGIGCDPSELSLSELERLTRVFTQKI 128
Query: 132 YDVISPYEDIPAPDVYTNPQIMAWMMDEYETIARRKTPAFGIITGKPLSIGGSLGRNEAT 191
+D+I + D+PAPD+ T PQ MAW++DEY +PA ++TGKP+ +GGSLGR+ AT
Sbjct: 129 HDLIGIHTDVPAPDMGTGPQTMAWILDEYSKF-HGHSPA--VVTGKPIDLGGSLGRDAAT 185
Query: 192 ARGASYTIREAAKVLGWDDLKGKTIAIQGYGNAGYYLAKIMSEDYGMKVVAVSDSKGGIY 251
RG + G + G+ AIQG+GN G + AK++S D G K+VAVSD G I
Sbjct: 186 GRGVLFATEALLNEHG-KTISGQRFAIQGFGNVGSWAAKLIS-DKGGKIVAVSDVTGAIK 243
Query: 252 NPDGLNADEVLKWKREHGSVKDFPGATNITNEELLELEVDVLAPAAIEEVITKKNADNIK 311
N +G++ +L+ E+ +K F GA +I + +L + D+L PAA+ VI ++NA+ IK
Sbjct: 244 NNNGIDILSLLEHAEENRGIKGFDGADSIDPDSILVEDCDILVPAALGGVINRENANEIK 303
Query: 312 AKIVAEVANGPVTPEADEILFEKGILQIPDFLCNAGGVTVSYFEWVQNITGYYWTLEEVR 371
AK + E AN P PEADEIL +KG++ +PD N+GGVTVSYFEWVQNI G+ W E+V
Sbjct: 304 AKFIIEGANHPTDPEADEILKKKGVMILPDIYANSGGVTVSYFEWVQNIQGFMWDEEKVN 363
Query: 372 EKLDKKMTKAFYDVYNTAKEKNIHMRDAAYVVAVQRVYQAMLDRGW 417
+L MT+ F D+ + + +R A+ + + RV QA RGW
Sbjct: 364 RELKTYMTRGFKDLKEMCQTHSCDLRMGAFTLGINRVAQATTIRGW 409
>pir||T04342 glutamate dehydrogenase (EC 1.4.1.2) - maize
>gi|1931631|gb|AAB51596.1| (U93561) glutamate
dehydrogenase [Zea mays]
Length = 411
Score = 341 bits (865), Expect = 1e-92
Identities = 184/406 (45%), Positives = 255/406 (62%), Gaps = 5/406 (1%)
Query: 12 KQLERAAQYMKISEEALEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQYNWARGPTKGG 71
+ ++AA+ + + + + L P R ++V + DDG++ + GFRVQ++ ARGP KGG
Sbjct: 9 RNFKQAAKLVGLDSKLEKSLLIPFREIKVECTIPKDDGTLASYVGFRVQHDNARGPMKGG 68
Query: 72 IRWHPEETLSTVKALAAWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREKERLARGYIRAI 131
IR+H E V ALA MTWKTAV ++PYGG KGGI P LS E ERL R + + I
Sbjct: 69 IRYHHEVDPDEVNALAQLMTWKTAVANIPYGGAKGGIGCSPGDLSISELERLTRVFTQKI 128
Query: 132 YDVISPYEDIPAPDVYTNPQIMAWMMDEYETIARRKTPAFGIITGKPLSIGGSLGRNEAT 191
+D+I + D+PAPD+ TN Q MAW++DEY +PA ++TGKP+ +GGSLGR+ AT
Sbjct: 129 HDLIGIHTDVPAPDMGTNSQTMAWILDEYSKF-HGYSPA--VVTGKPVDLGGSLGRDAAT 185
Query: 192 ARGASYTIREAAKVLGWDDLKGKTIAIQGYGNAGYYLAKIMSEDYGMKVVAVSDSKGGIY 251
RG + EA + G+ IQG+GN G + A+++SE G KV+A+SD G +
Sbjct: 186 GRGVLFAT-EALLAEHGKGIAGQRFVIQGFGNVGSWAAQLISEAGG-KVIAISDVTGAVK 243
Query: 252 NPDGLNADEVLKWKREHGSVKDFPGATNITNEELLELEVDVLAPAAIEEVITKKNADNIK 311
N DGL+ +++K E+ +K F G I + LL E DVL PAA+ VI K NA++IK
Sbjct: 244 NVDGLDIAQLVKHSAENKGIKGFKGGDAIAPDSLLTEECDVLIPAALGGVINKDNANDIK 303
Query: 312 AKIVAEVANGPVTPEADEILFEKGILQIPDFLCNAGGVTVSYFEWVQNITGYYWTLEEVR 371
AK + E AN P PEADEIL +KG+L +PD L N+GGVTVSYFEWVQNI G+ W E+V
Sbjct: 304 AKYIIEAANHPTDPEADEILSKKGVLILPDILANSGGVTVSYFEWVQNIQGFMWDEEKVN 363
Query: 372 EKLDKKMTKAFYDVYNTAKEKNIHMRDAAYVVAVQRVYQAMLDRGW 417
+L MT+AF DV + + +R A+ + V RV +A + RGW
Sbjct: 364 AELRTYMTRAFGDVKQMCRSHSCDLRMGAFTLGVNRVARATVLRGW 409
>pir||T04341 glutamate dehydrogenase mutant - maize >gi|1931629|gb|AAB51595.1|
(U93560) glutamate dehydrogenase mutant [Zea mays]
Length = 411
Score = 338 bits (858), Expect = 7e-92
Identities = 184/406 (45%), Positives = 253/406 (61%), Gaps = 5/406 (1%)
Query: 12 KQLERAAQYMKISEEALEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQYNWARGPTKGG 71
+ ++AA+ + + + + L P R ++V + DDG++ + GFRVQ++ ARGP KGG
Sbjct: 9 RNFKQAAKLVGLDSKLEKSLLIPFREIKVECTIPKDDGTLASYVGFRVQHDNARGPMKGG 68
Query: 72 IRWHPEETLSTVKALAAWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREKERLARGYIRAI 131
IR+H E V ALA MTWKTAV ++PYGG KGGI P LS E ERL R + + I
Sbjct: 69 IRYHHEVDPDEVNALAQLMTWKTAVANIPYGGAKGGIGCSPGDLSISELERLTRVFTQKI 128
Query: 132 YDVISPYEDIPAPDVYTNPQIMAWMMDEYETIARRKTPAFGIITGKPLSIGGSLGRNEAT 191
+D+I + D+PAPD+ TN Q MAW++DEY +PA ++TGKP+ +GGSLGR+ AT
Sbjct: 129 HDLIGIHTDVPAPDMGTNSQTMAWILDEYSKF-HGYSPA--VVTGKPVDLGGSLGRDAAT 185
Query: 192 ARGASYTIREAAKVLGWDDLKGKTIAIQGYGNAGYYLAKIMSEDYGMKVVAVSDSKGGIY 251
R + EA + G+ IQG+GN G + A+++SE G KV+A+SD G +
Sbjct: 186 GRRVLFAT-EALLAEHGKGIAGQRFVIQGFGNVGSWAAQLISEAGG-KVIAISDVTGAVK 243
Query: 252 NPDGLNADEVLKWKREHGSVKDFPGATNITNEELLELEVDVLAPAAIEEVITKKNADNIK 311
N GL+ EV+K E+ +K F G I + LL E DVL PAA+ VI K NA++IK
Sbjct: 244 NVGGLDIAEVVKHSAENKGIKGFKGGDAIAPDSLLTEECDVLIPAALGGVINKDNANDIK 303
Query: 312 AKIVAEVANGPVTPEADEILFEKGILQIPDFLCNAGGVTVSYFEWVQNITGYYWTLEEVR 371
AK + E AN P PEADEIL +KG+L +PD L N+GGVTVSYFEWVQNI G+ W E+V
Sbjct: 304 AKYIIEAANHPTDPEADEILSKKGVLILPDILANSGGVTVSYFEWVQNIQGFMWDEEKVN 363
Query: 372 EKLDKKMTKAFYDVYNTAKEKNIHMRDAAYVVAVQRVYQAMLDRGW 417
+L MT+AF DV + + +R A+ + V RV +A + RGW
Sbjct: 364 AELQTYMTRAFGDVKQMCRSHSCDLRMGAFTLGVNRVARATVLRGW 409
>pir||T03294 glutamate dehydrogenase (EC 1.4.1.2) - maize
>gi|695411|dbj|BAA08445.1| (D49475) glutamate
dehydrogenase [Zea mays]
Length = 411
Score = 338 bits (857), Expect = 9e-92
Identities = 182/406 (44%), Positives = 255/406 (61%), Gaps = 5/406 (1%)
Query: 12 KQLERAAQYMKISEEALEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQYNWARGPTKGG 71
+ ++AA+ + + + + L P R ++V + DDG++ + GFRVQ++ ARGP KGG
Sbjct: 9 RNFKQAAKLLGLDSKLEKSLLIPFREIKVECTIPKDDGTLASYVGFRVQHDNARGPMKGG 68
Query: 72 IRWHPEETLSTVKALAAWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREKERLARGYIRAI 131
IR+H E V ALA MTWKTAV ++PYGG KGGI P LS E ERL R + + I
Sbjct: 69 IRYHHEVDPDEVNALAQLMTWKTAVANIPYGGAKGGIGCSPGDLSISELERLTRVFTQKI 128
Query: 132 YDVISPYEDIPAPDVYTNPQIMAWMMDEYETIARRKTPAFGIITGKPLSIGGSLGRNEAT 191
+D+I + D+PAPD+ TN Q MAW++DEY +PA ++TGKP+ +GGSLGR+ AT
Sbjct: 129 HDLIGIHTDVPAPDMGTNSQTMAWILDEYSKF-HGYSPA--VVTGKPVDLGGSLGRDAAT 185
Query: 192 ARGASYTIREAAKVLGWDDLKGKTIAIQGYGNAGYYLAKIMSEDYGMKVVAVSDSKGGIY 251
RG + EA + G+ IQG+GN G + A+++SE G KV+A+SD G +
Sbjct: 186 GRGVLFAT-EALLAEHGKGIAGQRFVIQGFGNVGSWAAQLISEAGG-KVIAISDVTGAVK 243
Query: 252 NPDGLNADEVLKWKREHGSVKDFPGATNITNEELLELEVDVLAPAAIEEVITKKNADNIK 311
N DGL+ +++K E+ +K F G I + LL E DVL PAA+ VI K NA++IK
Sbjct: 244 NVDGLDIAQLVKHSAENKGIKGFKGGDAIAPDSLLTEECDVLIPAALGGVINKDNANDIK 303
Query: 312 AKIVAEVANGPVTPEADEILFEKGILQIPDFLCNAGGVTVSYFEWVQNITGYYWTLEEVR 371
AK + E AN P PEADEIL +KG+L +PD L N+GGVTVSYFEWVQNI G+ W E+V
Sbjct: 304 AKYIIEAANHPTDPEADEILSKKGVLILPDILANSGGVTVSYFEWVQNIQGFMWDEEKVN 363
Query: 372 EKLDKKMTKAFYDVYNTAKEKNIHMRDAAYVVAVQRVYQAMLDRGW 417
+L +T+AF +V + + +R A+ + V RV +A + RGW
Sbjct: 364 AELRTYITRAFGNVKQMCRSHSCDLRMGAFTLGVNRVARATVLRGW 409
>emb|CAA09478.1| (AJ011096) glutamate dehydrogenase [Asparagus officinalis]
Length = 411
Score = 337 bits (854), Expect = 2e-91
Identities = 181/406 (44%), Positives = 253/406 (61%), Gaps = 5/406 (1%)
Query: 12 KQLERAAQYMKISEEALEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQYNWARGPTKGG 71
+ ++AA+ + + + + L P R ++V + DDG++ F GFRVQ++ ARGP KGG
Sbjct: 9 RNFKQAAKLLGLDPKLEKSLLIPFREIKVECTIPKDDGTLASFVGFRVQHDNARGPMKGG 68
Query: 72 IRWHPEETLSTVKALAAWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREKERLARGYIRAI 131
IR+H E V ALA MTWKTAV ++PYGG KGGI P LS E ERL R + + I
Sbjct: 69 IRYHSEVDPDEVNALAQLMTWKTAVANIPYGGAKGGIGCSPGDLSLSELERLTRVFTQKI 128
Query: 132 YDVISPYEDIPAPDVYTNPQIMAWMMDEYETIARRKTPAFGIITGKPLSIGGSLGRNEAT 191
+D+I + D+PAPD+ TN Q MAW++DEY +PA I+TGKP+ +GGSLGR+ AT
Sbjct: 129 HDLIGVHTDVPAPDMGTNAQTMAWILDEYSKF-HGYSPA--IVTGKPVDLGGSLGRDAAT 185
Query: 192 ARGASYTIREAAKVLGWDDLKGKTIAIQGYGNAGYYLAKIMSEDYGMKVVAVSDSKGGIY 251
RG + G + G+ IQG+GN G + A+++++ G KVVAVSD G I
Sbjct: 186 GRGVLFATEALLAEYG-KGISGQRFVIQGFGNVGSWAAQLITKAGG-KVVAVSDVTGAIK 243
Query: 252 NPDGLNADEVLKWKREHGSVKDFPGATNITNEELLELEVDVLAPAAIEEVITKKNADNIK 311
+ +GL+ + +LK+ ++ +K F G I + LL + DVL PAA+ VI ++NA++++
Sbjct: 244 HSNGLDIENLLKYSVKNRGIKGFSGGDAIDSNSLLTEDCDVLIPAALGGVINRENANDVR 303
Query: 312 AKIVAEVANGPVTPEADEILFEKGILQIPDFLCNAGGVTVSYFEWVQNITGYYWTLEEVR 371
AK + E AN P PEADEIL +KG+ +PD L N+GGVTVSYFEWVQNI G+ W E+V
Sbjct: 304 AKFIIEAANHPTDPEADEILSKKGVCILPDILANSGGVTVSYFEWVQNIQGFMWDEEKVN 363
Query: 372 EKLDKKMTKAFYDVYNTAKEKNIHMRDAAYVVAVQRVYQAMLDRGW 417
+L MTK F V K N +R A+ + V RV +A L RGW
Sbjct: 364 SELKTYMTKGFKHVKEMCKTHNCDLRMGAFTLGVNRVARATLLRGW 409
>gb|AAK42126.1| NAD specific glutamate dehydrogenase (gdhA-3) [Sulfolobus
solfataricus]
Length = 434
Score = 332 bits (843), Expect = 4e-90
Identities = 178/409 (43%), Positives = 258/409 (62%), Gaps = 8/409 (1%)
Query: 11 VKQLERAAQYMKISEEALEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQYNWARGPTKG 70
VK+L + + + + + LE L +P+R+++V I + DG ++ F G+R Q+N A GP KG
Sbjct: 29 VKKLYKVGELLGLDIDTLEALSQPERVIQVKIQIRGSDGKLRTFVGWRSQHNSALGPYKG 88
Query: 71 GIRWHPEETLSTVKALAAWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREKERLARGYIRA 130
G+R+ P T V AL+ MTWK +++ LPYGGGKGGI VDPKKL+ +E E L+R YI+
Sbjct: 89 GVRYSPNVTQEEVIALSMIMTWKNSLLLLPYGGGKGGIRVDPKKLTLKELEDLSRKYIQL 148
Query: 131 IYDVISPYEDIPAPDVYTNPQIMAWMMDEYETIARRKTPAFGIITGKPLSIGGSLGRNEA 190
I++ + DIPAPD+ TNPQ MAW +DEY I F + TGKP +GG R +
Sbjct: 149 IHNYLGSNVDIPAPDINTNPQTMAWFLDEYIKITGEVD--FAVFTGKPYELGGIGVRLYS 206
Query: 191 TARGASYTIREAA-KVLGWDDLKGKTIAIQGYGNAGYYLAKIMSEDYGMKVVAVSDSKGG 249
T G + REAA K +G ++G + IQG+GN G + AK +SE G K++ VSD GG
Sbjct: 207 TGLGVATIAREAANKFIG--GIEGSRVIIQGFGNVGSFTAKFLSE-MGAKIIGVSDIGGG 263
Query: 250 IYNPDGLNADEVLKWKREHGSVKDFPGATNITNEELLELEVDVLAPAAIEEVITKKNADN 309
+ N +G++ ++ L+ + GSV ++P +TNEELL + D+L PAA+E VI K NA
Sbjct: 264 VINENGIDVNKALEVVQRTGSVVNYPEGKKVTNEELLISDCDILIPAAVENVINKFNAPK 323
Query: 310 IKAKIVAEVANGPVTPEADEILFEKGILQIPDFLCNAGGVTVSYFEWVQNITGYYWTLEE 369
+KAK++ E ANGP+T +AD+++ + GI+ IPD L NAGGV SY EW N +G + EE
Sbjct: 324 VKAKLIVEGANGPLTADADDVIKQSGIVVIPDILANAGGVVGSYVEWANNKSGGIISDEE 383
Query: 370 VREKLDKKMTKAFYDVYNTAKEK--NIHMRDAAYVVAVQRVYQAMLDRG 416
++ + +MT AF +Y+ K K + +R A +AV RV +AM RG
Sbjct: 384 AKKLIIDRMTNAFNTLYDFHKRKFADQDLRTVAMALAVDRVVKAMKARG 432
>pir||JC6317 glutamate dehydrogenase (EC 1.4.1.2) precursor - tomato
>gi|1762148|gb|AAB39508.1| (U48695) glutamate
dehydrogenase [Lycopersicon esculentum]
Length = 412
Score = 331 bits (840), Expect = 8e-90
Identities = 184/407 (45%), Positives = 247/407 (60%), Gaps = 6/407 (1%)
Query: 12 KQLERAAQYMKISEEALEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQYNWARGPTKGG 71
+ + AA+ + + + L P R ++V + DDG++ F GFRVQ++ ARGP KGG
Sbjct: 9 RNFKLAARLLGLDSKLELSLLIPFREIKVECTIPKDDGTLASFVGFRVQHDNARGPMKGG 68
Query: 72 IRWHPEETLSTVKALAAWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREKERLARGYIRAI 131
IR+HPE V ALA MTWKTAV ++PYGG KGGI P LS E ERL R + + I
Sbjct: 69 IRYHPEVDPDEVNALAQLMTWKTAVANIPYGGAKGGIGCSPSDLSISELERLTRVFTQKI 128
Query: 132 YDVISPYEDIPAPDVYTNPQIMAWMMDEYETIARRKTPAFGIITGKPLSIGGSLGRNEAT 191
+D+I + D+PAPD+ TNPQ MAW++DEY +PA ++TGKP+ +GGSLGR+ AT
Sbjct: 129 HDLIGIHTDVPAPDMGTNPQTMAWILDEYSKF-HGYSPA--VVTGKPVDLGGSLGRDAAT 185
Query: 192 ARGASYTIREAAKVLGWDDLKGKTIAIQGYGNAGYYLAKIMSEDYGMKVVAVSDSKGGIY 251
RGA + G + G+ IQG+GN G + AK++ E G KVVAVSD G I
Sbjct: 186 GRGALFATEALLNEHG-KSVAGQRFVIQGFGNVGSWAAKLIHEQ-GGKVVAVSDITGAIK 243
Query: 252 NPDGLNADEVLKWKREHGSVKDFPGATNITNEELLELEVDVLAPAAIEEVITKKNAD-NI 310
N G++ + + K +E VK F A I +L + DVL PAA+ VI K N I
Sbjct: 244 NEKGIDIESLFKHVKETRGVKGFHDAHPIDANSILVEDCDVLIPAALGGVINKDNHKLKI 303
Query: 311 KAKIVAEVANGPVTPEADEILFEKGILQIPDFLCNAGGVTVSYFEWVQNITGYYWTLEEV 370
KAK + E AN P PEADEIL +KG+ +PD N+GGVTVSYFEWVQNI G+ W ++V
Sbjct: 304 KAKYIIEAANHPTDPEADEILSKKGVTILPDIYANSGGVTVSYFEWVQNIQGFMWDEKKV 363
Query: 371 REKLDKKMTKAFYDVYNTAKEKNIHMRDAAYVVAVQRVYQAMLDRGW 417
++L MT+ F DV + K N +R A+ + V RV +A + RGW
Sbjct: 364 NDELKTYMTRGFKDVKDMCKTHNCDLRMGAFTLGVNRVARATVLRGW 410
>gb|AAK41684.1| NAD specific glutamate dehydrogenase (gdhA-1) [Sulfolobus
solfataricus]
Length = 419
Score = 325 bits (825), Expect = 5e-88
Identities = 173/409 (42%), Positives = 256/409 (62%), Gaps = 8/409 (1%)
Query: 11 VKQLERAAQYMKISEEALEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQYNWARGPTKG 70
VK+L + + + + E ++ L +P+R+++V I + DG ++ F G+R Q+N A GP KG
Sbjct: 14 VKKLYKVGELLGLDSETIDVLSQPERVMQVKIQIRSSDGKLRTFIGWRSQHNSALGPYKG 73
Query: 71 GIRWHPEETLSTVKALAAWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREKERLARGYIRA 130
G+R+ P T V AL+ MTWK +++ LPYGGGKGGI VDPKKL+ +E E L+R Y++
Sbjct: 74 GVRYGPNVTQDEVIALSMIMTWKNSLLLLPYGGGKGGIRVDPKKLTLKELEDLSRKYVQL 133
Query: 131 IYDVISPYEDIPAPDVYTNPQIMAWMMDEYETIARRKTPAFGIITGKPLSIGGSLGRNEA 190
I+ + DIPAPD+ TNPQ MAW +DEY I + F + TGKP +GG R +
Sbjct: 134 IHKYLGSDVDIPAPDINTNPQTMAWFLDEYIKITGKVD--FAVFTGKPSELGGIGVRLYS 191
Query: 191 TARGASYTIREAA-KVLGWDDLKGKTIAIQGYGNAGYYLAKIMSEDYGMKVVAVSDSKGG 249
T G + R+AA K +G ++G + IQG+GN G++ AK +SE G K++ VSD GG
Sbjct: 192 TGLGVATIARDAANKFIG--GIEGSRVIIQGFGNVGFFTAKFLSE-MGAKIIGVSDIGGG 248
Query: 250 IYNPDGLNADEVLKWKREHGSVKDFPGATNITNEELLELEVDVLAPAAIEEVITKKNADN 309
+ N +G++ + L+ + GSV ++ +TNEELL + D+L PAA+E VI K NA
Sbjct: 249 VINENGIDVNRALEVVQSTGSVVNYLEGKKVTNEELLISDCDILIPAAVENVINKFNAPK 308
Query: 310 IKAKIVAEVANGPVTPEADEILFEKGILQIPDFLCNAGGVTVSYFEWVQNITGYYWTLEE 369
++AK++ E ANGP+T +ADEI+ ++G++ IPD L NAGGV SY EW N +G + EE
Sbjct: 309 VRAKLIVEGANGPLTADADEIMKQRGVIVIPDILANAGGVVGSYVEWANNRSGGIISDEE 368
Query: 370 VREKLDKKMTKAFYDVYNTAKEK--NIHMRDAAYVVAVQRVYQAMLDRG 416
++ + +M AF +Y+ K K + +R A +AV RV AM RG
Sbjct: 369 AKKLIVDRMINAFNTLYDFHKRKFADQDLRTVAMALAVDRVVGAMKARG 417
>emb|CAA52168.1| (X73990) glutamate dehydrogenase (NADP+) [Sulfolobus shibatae]
Length = 391
Score = 317 bits (805), Expect = 1e-85
Identities = 170/386 (44%), Positives = 243/386 (62%), Gaps = 8/386 (2%)
Query: 26 EALEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQYNWARGPTKGGIRWHPEETLSTVKA 85
+ LE L +P+R+++V I + DG +K F G+R Q+N A GP KGG+R+ P T V A
Sbjct: 3 DTLEALSQPERVIQVKIQIRGSDGKLKTFMGWRSQHNSALGPYKGGVRYSPNVTQDEVIA 62
Query: 86 LAAWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREKERLARGYIRAIYDVISPYEDIPAPD 145
L+ MTWK +++ LPYGGGKGGI VDPKKL+ +E E L+R Y++ I++ + DIPAPD
Sbjct: 63 LSMIMTWKNSLLLLPYGGGKGGIRVDPKKLTLKELEDLSRKYVQLIHNYLGSDVDIPAPD 122
Query: 146 VYTNPQIMAWMMDEYETIARRKTPAFGIITGKPLSIGGSLGRNEATARGASYTIREAA-K 204
+ TNPQ MAW +DEY I F + TGKP +GG R +T G + REAA K
Sbjct: 123 INTNPQTMAWFLDEYIKITGEVD--FAVFTGKPSELGGIGVRLYSTGLGVATIAREAANK 180
Query: 205 VLGWDDLKGKTIAIQGYGNAGYYLAKIMSEDYGMKVVAVSDSKGGIYNPDGLNADEVLKW 264
+G ++G + IQG+GN G + AK ++E G K++ VSD GG+ + DG++ ++ L+
Sbjct: 181 FIG--GIEGSRVIIQGFGNVGSFTAKFLNE-MGAKIIGVSDIGGGVISDDGIDVNKALEV 237
Query: 265 KREHGSVKDFPGATNITNEELLELEVDVLAPAAIEEVITKKNADNIKAKIVAEVANGPVT 324
+ GSV ++P +TNEELL + D+L PAA+E VI K NA +KAK++ E ANGP+
Sbjct: 238 VQSTGSVVNYPEGKKVTNEELLTSDCDILIPAAVENVINKFNAPKVKAKLIVEGANGPLA 297
Query: 325 PEADEILFEKGILQIPDFLCNAGGVTVSYFEWVQNITGYYWTLEEVREKLDKKMTKAFYD 384
+ADEI+ ++GI+ IPD L NAGGV SY EW N +G + EE ++ + +MT AF
Sbjct: 298 ADADEIIKQRGIVVIPDILANAGGVVGSYVEWANNKSGGIISDEEAKKLIIDRMTNAFNA 357
Query: 385 VYNTAKEK--NIHMRDAAYVVAVQRV 408
+Y K K + +R A + V RV
Sbjct: 358 LYEFHKRKFADQDLRTVAMALRVDRV 383
>sp|P39475|DHE4_SULSH NADP-SPECIFIC GLUTAMATE DEHYDROGENASE (NADP-GDH)
>gi|480821|pir||S37407 glutamate dehydrogenase (NADP+)
(EC 1.4.1.4) - Sulfolobus shibatae (fragment)
Length = 390
Score = 317 bits (805), Expect = 1e-85
Identities = 170/386 (44%), Positives = 243/386 (62%), Gaps = 8/386 (2%)
Query: 26 EALEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQYNWARGPTKGGIRWHPEETLSTVKA 85
+ LE L +P+R+++V I + DG +K F G+R Q+N A GP KGG+R+ P T V A
Sbjct: 2 DTLEALSQPERVIQVKIQIRGSDGKLKTFMGWRSQHNSALGPYKGGVRYSPNVTQDEVIA 61
Query: 86 LAAWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREKERLARGYIRAIYDVISPYEDIPAPD 145
L+ MTWK +++ LPYGGGKGGI VDPKKL+ +E E L+R Y++ I++ + DIPAPD
Sbjct: 62 LSMIMTWKNSLLLLPYGGGKGGIRVDPKKLTLKELEDLSRKYVQLIHNYLGSDVDIPAPD 121
Query: 146 VYTNPQIMAWMMDEYETIARRKTPAFGIITGKPLSIGGSLGRNEATARGASYTIREAA-K 204
+ TNPQ MAW +DEY I F + TGKP +GG R +T G + REAA K
Sbjct: 122 INTNPQTMAWFLDEYIKITGEVD--FAVFTGKPSELGGIGVRLYSTGLGVATIAREAANK 179
Query: 205 VLGWDDLKGKTIAIQGYGNAGYYLAKIMSEDYGMKVVAVSDSKGGIYNPDGLNADEVLKW 264
+G ++G + IQG+GN G + AK ++E G K++ VSD GG+ + DG++ ++ L+
Sbjct: 180 FIG--GIEGSRVIIQGFGNVGSFTAKFLNE-MGAKIIGVSDIGGGVISDDGIDVNKALEV 236
Query: 265 KREHGSVKDFPGATNITNEELLELEVDVLAPAAIEEVITKKNADNIKAKIVAEVANGPVT 324
+ GSV ++P +TNEELL + D+L PAA+E VI K NA +KAK++ E ANGP+
Sbjct: 237 VQSTGSVVNYPEGKKVTNEELLTSDCDILIPAAVENVINKFNAPKVKAKLIVEGANGPLA 296
Query: 325 PEADEILFEKGILQIPDFLCNAGGVTVSYFEWVQNITGYYWTLEEVREKLDKKMTKAFYD 384
+ADEI+ ++GI+ IPD L NAGGV SY EW N +G + EE ++ + +MT AF
Sbjct: 297 ADADEIIKQRGIVVIPDILANAGGVVGSYVEWANNKSGGIISDEEAKKLIIDRMTNAFNA 356
Query: 385 VYNTAKEK--NIHMRDAAYVVAVQRV 408
+Y K K + +R A + V RV
Sbjct: 357 LYEFHKRKFADQDLRTVAMALRVDRV 382
>pir||G75452 probable glutamate dehydrogenase - Deinococcus radiodurans (strain
R1) >gi|6458708|gb|AAF10557.1|AE001950_9 (AE001950)
glutamate dehydrogenase, putative [Deinococcus
radiodurans]
Length = 392
Score = 294 bits (746), Expect = 9e-79
Identities = 148/327 (45%), Positives = 213/327 (64%), Gaps = 4/327 (1%)
Query: 93 KTAVMDLPYGGGKGGIIVDPKKLSDREKERLARGYIRAIYDVISPYEDIPAPDVYTNPQI 152
K A ++LPYGGGKGGI +DP+K S E ER+ R Y I +I P +DIPAPDV T PQ
Sbjct: 13 KNAAVNLPYGGGKGGIRIDPRKYSQGELERVTRRYTTEIGLIIGPEKDIPAPDVNTGPQT 72
Query: 153 MAWMMDEYETIARRKTPAFGIITGKPLSIGGSLGRNEATARGASYTIREAAKVLGWDDLK 212
MAWMMD Y R A G++TGKP+S+GGSLGR +AT RG T EA K LG L+
Sbjct: 73 MAWMMDTYSMNVGRT--ATGVVTGKPVSLGGSLGRADATGRGVFVTGAEAMKKLGMP-LE 129
Query: 213 GKTIAIQGYGNAGYYLAKIMSEDYGMKVVAVSDSKGGIYNPDGLNADEVLKWKREHGSVK 272
G IA+QG+GN G A+I + +G K+VA+ D G I++ G++ + L R+ G +
Sbjct: 130 GARIAVQGFGNVGEAAARIFHQ-HGAKIVAIQDVTGTIHSAAGIDPGKALAHLRQTGKIT 188
Query: 273 DFPGATNITNEELLELEVDVLAPAAIEEVITKKNADNIKAKIVAEVANGPVTPEADEILF 332
G+ + ++ ++ DVL PAA+E+ IT +NAD I+A++V E ANGP P AD++L
Sbjct: 189 GLEGSEEMQKDDFWSVDCDVLIPAALEKQITLQNADKIRARLVVEGANGPTIPAADDLLA 248
Query: 333 EKGILQIPDFLCNAGGVTVSYFEWVQNITGYYWTLEEVREKLDKKMTKAFYDVYNTAKEK 392
+KG+ +PD L NAGGV+VSYFEWVQ+ + ++WT +E+ E+LD+ M +AF +++ ++
Sbjct: 249 QKGVTVVPDVLANAGGVSVSYFEWVQDFSSFFWTEDEINERLDRIMREAFQSLWDVKEQH 308
Query: 393 NIHMRDAAYVVAVQRVYQAMLDRGWVK 419
+ +R A Y+VA RV +A G ++
Sbjct: 309 GVTLRTAVYIVACTRVLEARACAGCIR 335
>gi|6912392 Glutamate dehydrogenase-2 [Homo sapiens]
>gi|1352260|sp|P49448|DHE4_HUMAN GLUTAMATE DEHYDROGENASE
2 PRECURSOR (GDH) >gi|1071813|pir||A53719 glutamate
dehydrogenase (NAD(P)+) (EC 1.4.1.3) 2 precursor - human
>gi|31815|emb|CAA46995.1| (X66310) glutamate
dehydrogenase (NAD(P)+) [Homo sapiens]
>gi|478988|gb|AAA20969.1| (U08997) glutamate
dehydrogenase [Homo sapiens]
Length = 558
Score = 277 bits (702), Expect = 1e-73
Identities = 163/451 (36%), Positives = 241/451 (53%), Gaps = 64/451 (14%)
Query: 28 LEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQYNWARGPTKGGIRWHPEETLSTVKALA 87
L +K ++ ++ P+ DDGS +V G+R Q++ R P KGGIR+ + ++ VKALA
Sbjct: 106 LRIIKPCNHVLSLSFPIRRDDGSWEVIEGYRAQHSQHRTPCKGGIRYSTDVSVDEVKALA 165
Query: 88 AWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREKERLARGYIRAIYD--VISPYEDIPAPD 145
+ MT+K AV+D+P+GG K G+ ++PK ++ E E++ R + + I P D+PAPD
Sbjct: 166 SLMTYKCAVVDVPFGGAKAGVKINPKNYTENELEKITRRFTMELAKKGFIGPGVDVPAPD 225
Query: 146 VYTNPQIMAWMMDEY-ETIARRKTPAFGIITGKPLSIGGSLGRNEATARGASYTIREAAK 204
+ T + M+W+ D Y TI A +TGKP+S GG GR AT RG + I
Sbjct: 226 MNTGEREMSWIADTYASTIGHYDINAHACVTGKPISQGGIHGRISATGRGVFHGIENFIN 285
Query: 205 VLGWDDLKG-------KTIAIQGYGNAGYYLAKIMSEDYGMKVVAVSDSKGGIYNPDGLN 257
+ + G KT +QG+GN G + + + +G K +AV +S G I+NPDG++
Sbjct: 286 QASYMSILGMTPGFRDKTFVVQGFGNVGLHSMRYLHR-FGAKCIAVGESDGSIWNPDGID 344
Query: 258 ADEVLKWKREHGSVKDFPGATNITNEELLELEVDVLAPAAIEEVITKKNADNIKAKIVAE 317
E+ +K +HGS+ FP A +LE++ D+L PAA E+ +TK NA +KAKI+AE
Sbjct: 345 PKELEDFKLQHGSILGFPKAKPYEGS-ILEVDCDILIPAATEKQLTKSNAPRVKAKIIAE 403
Query: 318 VANGPVTPEADEILFEKGILQIPDFLCNAGGVTVSYFEWVQNIT--------------GY 363
ANGP TPEAD+I E+ IL IPD NAGGVTVSYFEW++N+
Sbjct: 404 GANGPTTPEADKIFLERNILVIPDLYLNAGGVTVSYFEWLKNLNHVSYGRLTFKYERDSN 463
Query: 364 YWTLEEVREKLDKKM-----------TKAFYDVYNTAKEKNI------------------ 394
Y L V+E L++K T F D + A EK+I
Sbjct: 464 YHLLLSVQESLERKFGKHGGTIPIVPTAEFQDSISGASEKDIVHSALAYTMERSARQIMH 523
Query: 395 ---------HMRDAAYVVAVQRVYQAMLDRG 416
+R AAYV A+++V++ + G
Sbjct: 524 TAMKYNLGLDLRTAAYVNAIEKVFKVYSEAG 554
>gi|11422617 Glutamate dehydrogenase-2 [Homo sapiens] >gi|4156204|gb|AAD05030.1|
(AC006144) glutamate dehydrogenase 2 precursor [Homo
sapiens]
Length = 558
Score = 277 bits (702), Expect = 1e-73
Identities = 163/451 (36%), Positives = 241/451 (53%), Gaps = 64/451 (14%)
Query: 28 LEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQYNWARGPTKGGIRWHPEETLSTVKALA 87
L +K ++ ++ P+ DDGS +V G+R Q++ R P KGGIR+ + ++ VKALA
Sbjct: 106 LRIIKPCNHVLSLSFPIRRDDGSWEVIEGYRAQHSQHRTPCKGGIRYSTDVSVDEVKALA 165
Query: 88 AWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREKERLARGYIRAIYD--VISPYEDIPAPD 145
+ MT+K AV+D+P+GG K G+ ++PK ++ E E++ R + + I P D+PAPD
Sbjct: 166 SLMTYKCAVVDVPFGGAKAGVKINPKNYTENELEKITRRFTMELAKKGFIGPGVDVPAPD 225
Query: 146 VYTNPQIMAWMMDEY-ETIARRKTPAFGIITGKPLSIGGSLGRNEATARGASYTIREAAK 204
+ T + M+W+ D Y TI A +TGKP+S GG GR AT RG + I
Sbjct: 226 MNTGEREMSWIADTYASTIGHYDINAHACVTGKPISQGGIHGRISATGRGVFHGIENFIN 285
Query: 205 VLGWDDLKG-------KTIAIQGYGNAGYYLAKIMSEDYGMKVVAVSDSKGGIYNPDGLN 257
+ + G KT +QG+GN G + + + +G K +AV +S G I+NPDG++
Sbjct: 286 EASYMSILGMTPGFRDKTFVVQGFGNVGLHSMRYLHR-FGAKCIAVGESDGSIWNPDGID 344
Query: 258 ADEVLKWKREHGSVKDFPGATNITNEELLELEVDVLAPAAIEEVITKKNADNIKAKIVAE 317
E+ +K +HGS+ FP A +LE++ D+L PAA E+ +TK NA +KAKI+AE
Sbjct: 345 PKELEDFKLQHGSILGFPKAKPYEGS-ILEVDCDILIPAATEKQLTKSNAPRVKAKIIAE 403
Query: 318 VANGPVTPEADEILFEKGILQIPDFLCNAGGVTVSYFEWVQNIT--------------GY 363
ANGP TPEAD+I E+ IL IPD NAGGVTVSYFEW++N+
Sbjct: 404 GANGPTTPEADKIFLERNILVIPDLYLNAGGVTVSYFEWLKNLNHVSYGRLTFKYERDSN 463
Query: 364 YWTLEEVREKLDKKM-----------TKAFYDVYNTAKEKNI------------------ 394
Y L V+E L++K T F D + A EK+I
Sbjct: 464 YHLLLSVQESLERKFGKHGGTIPIVPTAEFQDSISGASEKDIVHSALAYTMERSARQIMH 523
Query: 395 ---------HMRDAAYVVAVQRVYQAMLDRG 416
+R AAYV A+++V++ + G
Sbjct: 524 TAMKYNLGLDLRTAAYVNAIEKVFKVYSEAG 554
>gi|6980956 glutamate dehydrogenase [Rattus norvegicus]
>gi|56198|emb|CAA32202.1| (X14044) glutamate
dehydrogenase (AA 1-558) [Rattus norvegicus]
Length = 558
Score = 277 bits (701), Expect = 2e-73
Identities = 167/477 (35%), Positives = 247/477 (51%), Gaps = 64/477 (13%)
Query: 2 VEQDPFEIAVKQLERAAQYMKISEEALEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQY 61
+ +D +K E Q L +K ++ ++ P+ DDGS +V G+R Q+
Sbjct: 80 IVEDKLVEDLKTRENEEQKRNRVRGILRIIKPCNHVLSLSFPIRRDDGSWEVIEGYRAQH 139
Query: 62 NWARGPTKGGIRWHPEETLSTVKALAAWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREKE 121
+ R P KGGIR+ + ++ VKALA+ MT+K AV+D+P+GG K G+ ++PK +D E E
Sbjct: 140 SQHRTPCKGGIRYSTDVSVDEVKALASLMTYKCAVVDVPFGGAKAGVKINPKNYTDNELE 199
Query: 122 RLARGYIRAIYD--VISPYEDIPAPDVYTNPQIMAWMMDEY-ETIARRKTPAFGIITGKP 178
++ R + + I P D+PAPD+ T + M+W+ D Y TI A +TGKP
Sbjct: 200 KITRRFTMELAKKGFIGPGIDVPAPDMSTGEREMSWIADTYASTIGHYDINAHACVTGKP 259
Query: 179 LSIGGSLGRNEATARGASYTIREAAKVLGWDDLKG-------KTIAIQGYGNAGYYLAKI 231
+S GG GR AT RG + I + + G KT +QG+GN G + +
Sbjct: 260 ISQGGIHGRISATGRGVFHGIENFINEASYMSILGMTPGLGDKTFVVQGFGNVGLHSMRY 319
Query: 232 MSEDYGMKVVAVSDSKGGIYNPDGLNADEVLKWKREHGSVKDFPGATNITNEELLELEVD 291
+ +G K V V +S G I+NPDG++ E+ +K +HGS+ FP A + +LE + D
Sbjct: 320 LHR-FGAKCVGVGESDGSIWNPDGIDPKELEDFKLQHGSILGFPKA-KVYEGSILEADCD 377
Query: 292 VLAPAAIEEVITKKNADNIKAKIVAEVANGPVTPEADEILFEKGILQIPDFLCNAGGVTV 351
+L PAA E+ +TK NA +KAKI+AE ANGP TPEAD+I E+ I+ IPD NAGGVTV
Sbjct: 378 ILIPAASEKQLTKSNAPRVKAKIIAEGANGPTTPEADKIFLERNIMVIPDLYLNAGGVTV 437
Query: 352 SYFEWVQNIT--------------GYYWTLEEVREKLDKKM-----------TKAFYDVY 386
SYFEW++N+ Y L V+E L++K T F D
Sbjct: 438 SYFEWLKNLNHVSYGRLTFKYERDSNYHLLMSVQESLERKFGKHGGTIPVVPTAEFQDRI 497
Query: 387 NTAKEKNI---------------------------HMRDAAYVVAVQRVYQAMLDRG 416
+ A EK+I +R AAYV A+++V++ + G
Sbjct: 498 SGASEKDIVHSGLAYTMERSARQIMRTAMKYNLGLDLRTAAYVNAIEKVFKVYNEAG 554
>sp|P10860|DHE3_RAT GLUTAMATE DEHYDROGENASE PRECURSOR (GDH) >gi|92291|pir||S03707
glutamate dehydrogenase (NAD(P)+) (EC 1.4.1.3) precursor
- rat >gi|56200|emb|CAA32441.1| (X14223) glutamate
dehydrogenase (AA -53 to 505) [Rattus norvegicus]
Length = 558
Score = 277 bits (701), Expect = 2e-73
Identities = 167/477 (35%), Positives = 247/477 (51%), Gaps = 64/477 (13%)
Query: 2 VEQDPFEIAVKQLERAAQYMKISEEALEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQY 61
+ +D +K E Q L +K ++ ++ P+ DDGS +V G+R Q+
Sbjct: 80 IVEDKLVEDLKTRENEEQKRNRVRGILRIIKPCNHVLSLSFPIRRDDGSWEVIEGYRAQH 139
Query: 62 NWARGPTKGGIRWHPEETLSTVKALAAWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREKE 121
+ R P KGGIR+ + ++ VKALA+ MT+K AV+D+P+GG K G+ ++PK +D E E
Sbjct: 140 SQHRTPCKGGIRYSTDVSVDEVKALASLMTYKCAVVDVPFGGAKAGVKINPKNYTDNELE 199
Query: 122 RLARGYIRAIYD--VISPYEDIPAPDVYTNPQIMAWMMDEY-ETIARRKTPAFGIITGKP 178
++ R + + I P D+PAPD+ T + M+W+ D Y TI A +TGKP
Sbjct: 200 KITRRFTMELAKKGFIGPGIDVPAPDMSTGEREMSWIADTYASTIGHYDINAHACVTGKP 259
Query: 179 LSIGGSLGRNEATARGASYTIREAAKVLGWDDLKG-------KTIAIQGYGNAGYYLAKI 231
+S GG GR AT RG + I + + G KT +QG+GN G + +
Sbjct: 260 ISQGGIHGRISATGRGVFHGIENFINEASYMSILGMTPGLGDKTFVVQGFGNVGLHSMRY 319
Query: 232 MSEDYGMKVVAVSDSKGGIYNPDGLNADEVLKWKREHGSVKDFPGATNITNEELLELEVD 291
+ +G K V V +S G I+NPDG++ E+ +K +HGS+ FP A + +LE + D
Sbjct: 320 LHR-FGAKCVGVGESDGSIWNPDGIDPKELEDFKLQHGSILGFPKA-KVYEGSILEADCD 377
Query: 292 VLAPAAIEEVITKKNADNIKAKIVAEVANGPVTPEADEILFEKGILQIPDFLCNAGGVTV 351
+L PAA E+ +TK NA +KAKI+AE ANGP TPEAD+I E+ I+ IPD NAGGVTV
Sbjct: 378 ILIPAASEKQLTKSNAPRVKAKIIAEGANGPTTPEADKIFLERNIMVIPDLYLNAGGVTV 437
Query: 352 SYFEWVQNIT--------------GYYWTLEEVREKLDKKM-----------TKAFYDVY 386
SYFEW++N+ Y L V+E L++K T F D
Sbjct: 438 SYFEWLKNLNHVSYGRLTFKYERDSNYHLLMSVQESLERKFGKHGGTIPVVPTAEFQDRI 497
Query: 387 NTAKEKNI---------------------------HMRDAAYVVAVQRVYQAMLDRG 416
+ A EK+I +R AAYV A+++V++ + G
Sbjct: 498 SGASEKDIVHSGLAYTMERSARQIMRTAMKYNLGLDLRTAAYVNAIEKVFKVYNEAG 554
>gi|6680027 glutamate dehydrogenase [Mus musculus]
>gi|118542|sp|P26443|DHE3_MOUSE GLUTAMATE DEHYDROGENASE
PRECURSOR (GDH) >gi|90522|pir||S16239 glutamate
dehydrogenase (NAD(P)+) (EC 1.4.1.3) precursor - mouse
>gi|51082|emb|CAA40341.1| (X57024) glutamate
dehydrogenase (NAD(P)+) [Mus musculus]
Length = 558
Score = 277 bits (700), Expect = 2e-73
Identities = 163/451 (36%), Positives = 240/451 (53%), Gaps = 64/451 (14%)
Query: 28 LEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQYNWARGPTKGGIRWHPEETLSTVKALA 87
L +K ++ ++ P+ DDGS +V G+R Q++ R P KGGIR+ + ++ VKALA
Sbjct: 106 LRIIKPCNHVLSLSFPIRRDDGSWEVIEGYRAQHSQHRTPCKGGIRYSTDVSVDEVKALA 165
Query: 88 AWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREKERLARGYIRAIYD--VISPYEDIPAPD 145
+ MT+K AV+D+P+GG K G+ ++PK +D E E++ R + + I P D+PAPD
Sbjct: 166 SLMTYKCAVVDVPFGGAKAGVKINPKNYTDNELEKITRRFTMELAKKGFIGPGIDVPAPD 225
Query: 146 VYTNPQIMAWMMDEY-ETIARRKTPAFGIITGKPLSIGGSLGRNEATARGASYTIREAAK 204
+ T + M+W+ D Y TI A +TGKP+S GG GR AT RG + I
Sbjct: 226 MSTGEREMSWIADTYASTIGHYDINAHACVTGKPISQGGIHGRISATGRGVFHGIENFIN 285
Query: 205 VLGWDDLKG-------KTIAIQGYGNAGYYLAKIMSEDYGMKVVAVSDSKGGIYNPDGLN 257
+ + G KT +QG+GN G + + + +G K V V +S G I+NPDG++
Sbjct: 286 EASYMSILGMTPGFGDKTFVVQGFGNVGLHSMRYLHR-FGAKCVGVGESDGSIWNPDGID 344
Query: 258 ADEVLKWKREHGSVKDFPGATNITNEELLELEVDVLAPAAIEEVITKKNADNIKAKIVAE 317
E+ +K +HGS+ FP A + +LE + D+L PAA E+ +TK NA +KAKI+AE
Sbjct: 345 PKELEDFKLQHGSILGFPKA-KVYEGSILEADCDILIPAASEKQLTKSNAPRVKAKIIAE 403
Query: 318 VANGPVTPEADEILFEKGILQIPDFLCNAGGVTVSYFEWVQNIT--------------GY 363
ANGP TPEAD+I E+ I+ IPD NAGGVTVSYFEW++N+
Sbjct: 404 GANGPTTPEADKIFLERNIMVIPDLYLNAGGVTVSYFEWLKNLNHVSYGRLTFKYERDSN 463
Query: 364 YWTLEEVREKLDKKM-----------TKAFYDVYNTAKEKNI------------------ 394
Y L V+E L++K T F D + A EK+I
Sbjct: 464 YHLLMSVQESLERKFGKHGGTIPVVPTAEFQDRISGASEKDIVHSGLAYTMERSARQIMR 523
Query: 395 ---------HMRDAAYVVAVQRVYQAMLDRG 416
+R AAYV A+++V++ + G
Sbjct: 524 TAMKYNLGLDLRTAAYVNAIEKVFKVYNEAG 554
>gi|4885281 glutamate dehydrogenase 1 [Homo sapiens]
>gi|118541|sp|P00367|DHE3_HUMAN GLUTAMATE DEHYDROGENASE
1 PRECURSOR (GDH) >gi|66081|pir||DEHUE glutamate
dehydrogenase (NAD(P)+) (EC 1.4.1.3) precursor - human
>gi|31707|emb|CAA30521.1| (X07674) GDH [Homo sapiens]
>gi|31799|emb|CAA30598.1| (X07769) glutamate
dehydrogenase [Homo sapiens] >gi|183054|gb|AAA52523.1|
(J03248) glutamate dehydrogenase precursor [Homo
sapiens] >gi|183058|gb|AAA52525.1| (M37154) glutamate
dehydrogenase [Homo sapiens] >gi|183060|gb|AAA52526.1|
(M20867) glutamate dehydrogenase precursor (EC 1.4.1.3.)
[Homo sapiens] >gi|5738667|emb|CAA46994.2| (X66300)
glutamate dehydrogenase (NAD(P)+) [Homo sapiens]
Length = 558
Score = 276 bits (699), Expect = 3e-73
Identities = 163/451 (36%), Positives = 240/451 (53%), Gaps = 64/451 (14%)
Query: 28 LEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQYNWARGPTKGGIRWHPEETLSTVKALA 87
L +K ++ ++ P+ DDGS +V G+R Q++ R P KGGIR+ + ++ VKALA
Sbjct: 106 LRIIKPCNHVLSLSFPIRRDDGSWEVIEGYRAQHSQHRTPCKGGIRYSTDVSVDEVKALA 165
Query: 88 AWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREKERLARGYIRAIYD--VISPYEDIPAPD 145
+ MT+K AV+D+P+GG K G+ ++PK +D E E++ R + + I P D+PAPD
Sbjct: 166 SLMTYKCAVVDVPFGGAKAGVKINPKNYTDNELEKITRRFTMELAKKGFIGPGIDVPAPD 225
Query: 146 VYTNPQIMAWMMDEY-ETIARRKTPAFGIITGKPLSIGGSLGRNEATARGASYTIREAAK 204
+ T + M+W+ D Y TI A +TGKP+S GG GR AT RG + I
Sbjct: 226 MSTGEREMSWIADTYASTIGHYDINAHACVTGKPISQGGIHGRISATGRGVFHGIENFIN 285
Query: 205 VLGWDDLKG-------KTIAIQGYGNAGYYLAKIMSEDYGMKVVAVSDSKGGIYNPDGLN 257
+ + G KT +QG+GN G + + + +G K +AV +S G I+NPDG++
Sbjct: 286 EASYMSILGMTPGFGDKTFVVQGFGNVGLHSMRYLHR-FGAKCIAVGESDGSIWNPDGID 344
Query: 258 ADEVLKWKREHGSVKDFPGATNITNEELLELEVDVLAPAAIEEVITKKNADNIKAKIVAE 317
E+ +K +HGS+ FP A +LE + D+L PAA E+ +TK NA +KAKI+AE
Sbjct: 345 PKELEDFKLQHGSILGFPKAKPYEGS-ILEADCDILIPAASEKQLTKSNAPRVKAKIIAE 403
Query: 318 VANGPVTPEADEILFEKGILQIPDFLCNAGGVTVSYFEWVQNIT--------------GY 363
ANGP TPEAD+I E+ I+ IPD NAGGVTVSYFEW++N+
Sbjct: 404 GANGPTTPEADKIFLERNIMVIPDLYLNAGGVTVSYFEWLKNLNHVSYGRLTFKYERDSN 463
Query: 364 YWTLEEVREKLDKKM-----------TKAFYDVYNTAKEKNI------------------ 394
Y L V+E L++K T F D + A EK+I
Sbjct: 464 YHLLMSVQESLERKFGKHGGTIPIVPTAEFQDRISGASEKDIVHSGLAYTMERSARQIMR 523
Query: 395 ---------HMRDAAYVVAVQRVYQAMLDRG 416
+R AAYV A+++V++ + G
Sbjct: 524 TAMKYNLGLDLRTAAYVNAIEKVFKVYNEAG 554
>gi|11430406 glutamate dehydrogenase 1 [Homo sapiens]
Length = 591
Score = 274 bits (693), Expect = 1e-72
Identities = 161/442 (36%), Positives = 237/442 (53%), Gaps = 64/442 (14%)
Query: 37 IVEVTIPVEMDDGSVKVFTGFRVQYNWARGPTKGGIRWHPEETLSTVKALAAWMTWKTAV 96
++ ++ P+ DDGS +V G+R Q++ R P KGGIR+ + ++ VKALA+ MT+K AV
Sbjct: 148 VLSLSFPIRRDDGSWEVIEGYRAQHSQHRTPCKGGIRYSTDVSVDEVKALASLMTYKCAV 207
Query: 97 MDLPYGGGKGGIIVDPKKLSDREKERLARGYIRAIYD--VISPYEDIPAPDVYTNPQIMA 154
+D+P+GG K G+ ++PK +D E E++ R + + I P D+PAPD+ T + M+
Sbjct: 208 VDVPFGGAKAGVKINPKNYTDNELEKITRRFTMELAKKGFIGPGIDVPAPDMSTGEREMS 267
Query: 155 WMMDEY-ETIARRKTPAFGIITGKPLSIGGSLGRNEATARGASYTIREAAKVLGWDDLKG 213
W+ D Y TI A +TGKP+S GG GR AT RG + I + + G
Sbjct: 268 WIADTYASTIGHYDINAHACVTGKPISQGGIHGRISATGRGVFHGIENFINEASYMSILG 327
Query: 214 -------KTIAIQGYGNAGYYLAKIMSEDYGMKVVAVSDSKGGIYNPDGLNADEVLKWKR 266
KT +QG+GN G + + + +G K +AV +S G I+NPDG++ E+ +K
Sbjct: 328 MTPGFGDKTFVVQGFGNVGLHSMRYLHR-FGAKCIAVGESDGSIWNPDGIDPKELEDFKL 386
Query: 267 EHGSVKDFPGATNITNEELLELEVDVLAPAAIEEVITKKNADNIKAKIVAEVANGPVTPE 326
+HGS+ FP A +LE + D+L PAA E+ +TK NA +KAKI+AE ANGP TPE
Sbjct: 387 QHGSILGFPKAKPYEGS-ILEADCDILIPAASEKQLTKSNAPRVKAKIIAEGANGPTTPE 445
Query: 327 ADEILFEKGILQIPDFLCNAGGVTVSYFEWVQNIT--------------GYYWTLEEVRE 372
AD+I E+ I+ IPD NAGGVTVSYFEW++N+ Y L V+E
Sbjct: 446 ADKIFLERNIMVIPDLYLNAGGVTVSYFEWLKNLNHVSYGRLTFKYERDSNYHLLMSVQE 505
Query: 373 KLDKKM-----------TKAFYDVYNTAKEKNI--------------------------- 394
L++K T F D + A EK+I
Sbjct: 506 SLERKFGKHGGTIPIVPTAEFQDRISGASEKDIVHSGLAYTMERSARQIMRTAMKYNLGL 565
Query: 395 HMRDAAYVVAVQRVYQAMLDRG 416
+R AAYV A+++V++ + G
Sbjct: 566 DLRTAAYVNAIEKVFKVYNEAG 587
>pdb|1CH6|A Chain A, Crystal Structure Of Bovine Liver Glutamate Dehydrogenase
Complexed With Gtp, Nadh, And L-Glutamic Acid
>gi|7767223|pdb|1CH6|B Chain B, Crystal Structure Of
Bovine Liver Glutamate Dehydrogenase Complexed With Gtp,
Nadh, And L-Glutamic Acid >gi|7767224|pdb|1CH6|C Chain
C, Crystal Structure Of Bovine Liver Glutamate
Dehydrogenase Complexed With Gtp, Nadh, And L-Glutamic
Acid >gi|7767225|pdb|1CH6|D Chain D, Crystal Structure
Of Bovine Liver Glutamate Dehydrogenase Complexed With
Gtp, Nadh, And L-Glutamic Acid >gi|7767226|pdb|1CH6|E
Chain E, Crystal Structure Of Bovine Liver Glutamate
Dehydrogenase Complexed With Gtp, Nadh, And L-Glutamic
Acid >gi|7767227|pdb|1CH6|F Chain F, Crystal Structure
Of Bovine Liver Glutamate Dehydrogenase Complexed With
Gtp, Nadh, And L-Glutamic Acid
Length = 501
Score = 270 bits (682), Expect = 3e-71
Identities = 160/451 (35%), Positives = 243/451 (53%), Gaps = 64/451 (14%)
Query: 28 LEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQYNWARGPTKGGIRWHPEETLSTVKALA 87
L +K ++ ++ P+ DDGS +V G+R Q++ R P KGGIR+ + ++ VKALA
Sbjct: 49 LRIIKPCNHVLSLSFPIRRDDGSWEVIEGYRAQHSHQRTPCKGGIRYSTDVSVDEVKALA 108
Query: 88 AWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREKERLARGYIRAIYD--VISPYEDIPAPD 145
+ MT+K AV+D+P+GG K G+ ++PK +D + E++ R + + I P D+PAP+
Sbjct: 109 SLMTYKCAVVDVPFGGAKAGVKINPKNYTDEDLEKITRRFTMELAKKGFIGPGVDVPAPN 168
Query: 146 VYTNPQIMAWMMDEY-ETIARRKTPAFGIITGKPLSIGGSLGRNEATARGASYTIREAAK 204
+ T + M+W+ D Y TI A +TGKP+S GG GR AT RG + I +
Sbjct: 169 MSTGEREMSWIADTYASTIGHYDINAHACVTGKPISQGGIHGRISATGRGVFHGIENFIE 228
Query: 205 VLGWDDLKG-------KTIAIQGYGNAGYYLAKIMSEDYGMKVVAVSDSKGGIYNPDGLN 257
+ + G KT A+QG+GN G + + + +G K VAV +S G I+NPDG++
Sbjct: 229 NASYMSILGMTPGFGDKTFAVQGFGNVGLHSMRYLHR-FGAKCVAVGESDGSIWNPDGID 287
Query: 258 ADEVLKWKREHGSVKDFPGATNITNEELLELEVDVLAPAAIEEVITKKNADNIKAKIVAE 317
E+ +K +HG++ FP A I +LE++ D+L PAA E+ +TK NA +KAKI+AE
Sbjct: 288 PKELEDFKLQHGTILGFPKA-KIYEGSILEVDCDILIPAASEKQLTKSNAPRVKAKIIAE 346
Query: 318 VANGPVTPEADEILFEKGILQIPDFLCNAGGVTVSYFEWVQNIT--------------GY 363
ANGP TP+AD+I E+ I+ IPD NAGGVTVSYF+ ++N+
Sbjct: 347 GANGPTTPQADKIFLERNIMVIPDLYLNAGGVTVSYFQILKNLNHVSYGRLTFKYERDSN 406
Query: 364 YWTLEEVREKLDKKM-----------TKAFYDVYNTAKEKNI------------------ 394
Y L V+E L++K T F D + A EK+I
Sbjct: 407 YHLLMSVQESLERKFGKHGGTIPIVPTAEFQDRISGASEKDIVHSGLAYTMERSARQIMR 466
Query: 395 ---------HMRDAAYVVAVQRVYQAMLDRG 416
+R AAYV A+++V++ + G
Sbjct: 467 TAMKYNLGLDLRTAAYVNAIEKVFRVYNEAG 497
>sp|P00366|DHE3_BOVIN GLUTAMATE DEHYDROGENASE (GDH) >gi|66082|pir||DEBOE glutamate
dehydrogenase (NAD(P)+) (EC 1.4.1.3) - bovine
(tentative sequence)
Length = 501
Score = 259 bits (654), Expect = 5e-68
Identities = 157/451 (34%), Positives = 239/451 (52%), Gaps = 64/451 (14%)
Query: 28 LEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQYNWARGPTKGGIRWHPEETLSTVKALA 87
L +K ++ ++ P+ DDGS +V G+R Q++ R P KGGIR+ + ++ VKALA
Sbjct: 49 LRIIKPCNHVLSLSFPIRRDDGSWEVIEGYRAQHSHQRTPCKGGIRYSTDVSVDEVKALA 108
Query: 88 AWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREKERLARGYIRAIYD--VISPYEDIPAPD 145
+ MT+K AV+D+P+GG K G+ ++PK +D + E++ R + + I P D+PAP+
Sbjct: 109 SLMTYKCAVVDVPFGGAKAGVKINPKNYTDEDLEKITRRFTMELAKKGFIGPGVDVPAPN 168
Query: 146 VYTNPQIMAWMMDEY-ETIARRKTPAFGIITGKPLSIGGSLGRNEATARGASYTIREAAK 204
+ T + M+W+ D Y TI A +T +S GG GR AT RG I +
Sbjct: 169 MSTGEREMSWIADTYASTIGHYDINAHACVTKPGISQGGIHGRISATGRGVFGHIENFIE 228
Query: 205 VLGWDDLKG-------KTIAIQGYGNAGYYLAKIMSEDYGMKVVAVSDSKGGIYNPDGLN 257
+ + G KT A+QG+GN G + + + +G K VAV +S G I+NPDG++
Sbjct: 229 NASYMSILGMTPGFGDKTFAVQGFGNVGLHSMRYLHR-FGAKCVAVGESDGSIWNPDGID 287
Query: 258 ADEVLKWKREHGSVKDFPGATNITNEELLELEVDVLAPAAIEEVITKKNADNIKAKIVAE 317
E+ +K +HG++ FP A I +LE++ D+L PAA E+ +TK NA +KAKI+AE
Sbjct: 288 PKELEDFKLQHGTILGFPKA-KIYEGSILEVDCDILIPAASEKQLTKSNAPRVKAKIIAE 346
Query: 318 VANGPVTPEADEILFEKGILQIPDFLCNAGGVTVSYFEWVQNIT--------------GY 363
ANGP TP+AD+I E+ I+ IPD NAGGVTVSYF+ ++N+
Sbjct: 347 GANGPTTPQADKIFLERNIMVIPDLYLNAGGVTVSYFQILKNLNHVSYGRLTFKYERDSN 406
Query: 364 YWTLEEVREKLDKKM-----------TKAFYDVYNTAKEKNI------------------ 394
Y L V+E L++K T F D + A EK+I
Sbjct: 407 YHLLMSVQESLERKFGKHGGTIPIVPTAEFQDRISGASEKDIVHSGLAYTMERSARQIMR 466
Query: 395 ---------HMRDAAYVVAVQRVYQAMLDRG 416
+R AAYV A+++V++ + G
Sbjct: 467 TAMKYNLGLDLRTAAYVNAIEKVFRVYNEAG 497
>gb|AAG15493.1| (AF279460) glutamate dehydrogenase [Paramecium tetraurelia]
Length = 460
Score = 258 bits (652), Expect = 9e-68
Identities = 160/450 (35%), Positives = 230/450 (50%), Gaps = 55/450 (12%)
Query: 15 ERAAQYMKISEEALEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQYNWARGPTKGGIRW 74
++AA I + L + K+ +++ +P+ DDG+V+ FR Q+ + PTKGG R
Sbjct: 4 DKAAALTNIPVDMLNYYKKTDCVIKFHLPLVRDDGTVECIPAFRAQHKTHKLPTKGGTRL 63
Query: 75 HPEETLSTVKALAAWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREKERLARGYI--RAIY 132
V+AL+ MT+K AV++LPYGG KGG+ ++PKK S RE E L R + A
Sbjct: 64 SEHIHTEEVEALSLLMTFKNAVLELPYGGAKGGLKINPKKYSKREIESLMRRFTIELAKR 123
Query: 133 DVISPYEDIPAPDVYTNPQIMAWMMDEYETIARR-KTPAFGIITGKPLSIGGSLGRNEAT 191
+ I D+P PD+ T + M+WM DEY A A G +TGK +S GG GR E+T
Sbjct: 124 NFIGAAIDVPGPDLGTGEREMSWMKDEYTKFAGHLDINAQGCVTGKAISQGGISGRTEST 183
Query: 192 ARGASYTIREAAKVLGW-------DDLKGKTIAIQGYGNAGYYLAKIMSEDYGMKVVAVS 244
G Y RE + + L+GK I IQGYG GYY AK M YG K+V V+
Sbjct: 184 GLGVFYGCREILEDYEFCTQAGIPAGLRGKNIIIQGYGAVGYYAAKYMCA-YGAKLVGVA 242
Query: 245 DSKGGIYNPDGLNADEVLKWKREHGSVKDFPGATNITNEE-LLELEVDVLAPAAIEEVIT 303
+ G IY +G++ DE+ +K + VK FP A+ +E ++ E D+ PAA E+ +
Sbjct: 243 EWDGSIYEENGIDPDELQAFKEQRKGVKGFPKASEYHEDESVIYKECDIFIPAAFEQTVN 302
Query: 304 KKNADNIKAKIVAEVANGPVTPEADEILFEKGILQIPDFLCNAGGVTVSYFEWVQNI--- 360
+ NA K++AE ANGP T A+EIL +KG+ +PD L NAGGVTVSY +W+QN+
Sbjct: 303 RANAPKFNCKVIAEAANGPTTLAAEEILIKKGVKFLPDILLNAGGVTVSYLQWLQNLDHI 362
Query: 361 -----------TGYYWTLEEVR-----------------------------EKLDKKMTK 380
T Y LE ++ L++ M
Sbjct: 363 RPGRMTRRWEETSKYKLLEAIQISTGLRVDVTKNQQAAKLLEGPSAKDLVFTGLEESMAV 422
Query: 381 AFYDVYNTAKEKNIHMRDAAYVVAVQRVYQ 410
A + TA + NI +R A Y A+ ++Q
Sbjct: 423 AVQNTKETASKLNISLRMAGYYNALMTIHQ 452
>gb|AAF56124.1| (AE003742) CG4434 gene product [Drosophila melanogaster]
Length = 520
Score = 257 bits (651), Expect = 1e-67
Identities = 145/360 (40%), Positives = 215/360 (59%), Gaps = 16/360 (4%)
Query: 11 VKQLERAAQYMKISEEALEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQYNWARGPTKG 70
+K ER A+ I L L VEV P+ +G+ ++ +G+R + R P KG
Sbjct: 57 MKPEERQARVTAI----LNLLGSVSTSVEVNFPIVRKNGTYEIISGYRSHHVRHRLPLKG 112
Query: 71 GIRWHPEETLSTVKALAAWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREKERLARGYIRA 130
GIR+ + S VKALAA MT+K A +++PYGG KGGI +DPKK + E + + R Y
Sbjct: 113 GIRYALDVNESEVKALAAIMTFKCACVNVPYGGSKGGICIDPKKYTVDELQTITRRYTME 172
Query: 131 IY--DVISPYEDIPAPDVYTNPQIMAWMMDEYE-TIARRKTPAFGIITGKPLSIGGSLGR 187
+ ++I P D+PAPDV T P+ M+W++D+Y+ T + + I+TGKP+ GG GR
Sbjct: 173 LLKRNMIGPGIDVPAPDVNTGPREMSWIVDQYQKTFGYKDINSSAIVTGKPVHNGGINGR 232
Query: 188 NEATARGASYTIREAAKVLGWDDL-------KGKTIAIQGYGNAGYYLAKIMSEDYGMKV 240
+ AT RG K W DL K KT+ +QG+GN G + AK + E G KV
Sbjct: 233 HSATGRGVWKAGDLFLKDKEWMDLLKWKTGWKDKTVIVQGFGNVGSFAAKYVHEA-GAKV 291
Query: 241 VAVSDSKGGIYNPDGLNADEVLKWKREHGSVKDFPGATNITNEELLELEVDVLAPAAIEE 300
+ + + + N DG++ +++ ++ E ++K +P A + E+LL E D+L P A ++
Sbjct: 292 IGIKEFDVSLVNKDGIDINDLFEYTEEKKTIKGYPKAQE-SKEDLLVAETDILMPCATQK 350
Query: 301 VITKKNADNIKAKIVAEVANGPVTPEADEILFEKGILQIPDFLCNAGGVTVSYFEWVQNI 360
VIT NA +IKAK++ E ANGP TP ++IL +KG+L +PD CNAGGVTVSYFE+++NI
Sbjct: 351 VITTDNAKDIKAKLILEGANGPTTPSGEKILLDKGVLLVPDLYCNAGGVTVSYFEYLKNI 410
>sp|P54385|DHE3_DROME GLUTAMATE DEHYDROGENASE PRECURSOR (GDH) >gi|542577|pir||S42919
glutamate dehydrogenase (NAD(P)+) (EC 1.4.1.3) - fruit
fly (Drosophila melanogaster)
>gi|458803|emb|CAA82304.1| (Z29062) glutamate
dehydrogenase, short peptide [Drosophila melanogaster]
Length = 549
Score = 256 bits (648), Expect = 3e-67
Identities = 149/445 (33%), Positives = 237/445 (52%), Gaps = 69/445 (15%)
Query: 37 IVEVTIPVEMDDGSVKVFTGFRVQYNWARGPTKGGIRWHPEETLSTVKALAAWMTWKTAV 96
I+E+ P+ D G+ ++ TG+R Q++ + PTKGGIR+ + + VKAL+A MT+K A
Sbjct: 106 IIEIAFPLRRDAGNYEMITGYRAQHSTHKTPTKGGIRFSLDVSRDEVKALSALMTFKCAC 165
Query: 97 MDLPYGGGKGGIIVDPKKLSDREKERLARGYIRAIYD--VISPYEDIPAPDVYTNPQIMA 154
+D+P+GG K G+ ++PK+ S+ E E++ R + + I P D+PAPD+ T + M+
Sbjct: 166 VDVPFGGAKAGLKINPKEYSEHELEKITRRFTLELAKKGFIGPGVDVPAPDMGTGEREMS 225
Query: 155 WMMDEY-ETIARRKTPAFGIITGKPLSIGGSLGRNEATARGASYTIR----------EAA 203
W+ D Y +TI A +TGKP++ GG GR AT RG + + +
Sbjct: 226 WIADTYAKTIGHLDINAHACVTGKPINQGGIHGRVSATGRGVFHGLENFINEANYMSQIG 285
Query: 204 KVLGWDDLKGKTIAIQGYGNAGYYLAKIMSEDYGMKVVAVSDSKGGIYNPDGLNADEVLK 263
GW GKT +QG+GN G + + ++ G + V + G +YNP+G++ +
Sbjct: 286 TTPGWG---GKTFIVQGFGNVGLHTTRYLTRA-GATCIGVIEHDGTLYNPEGIDPKLLED 341
Query: 264 WKREHGSVKDFPGATNITNEELLELEVDVLAPAAIEEVITKKNADNIKAKIVAEVANGPV 323
+K EHG++ + A E L+ + D+ PAA+E+VIT +NA+ I+AKI+AE ANGP
Sbjct: 342 YKNEHGTIVGYQNAKPYEGENLMFEKCDIFIPAAVEKVITSENANRIQAKIIAEAANGPT 401
Query: 324 TPEADEILFEKGILQIPDFLCNAGGVTVSYFEWVQNIT--------------GYYWTLEE 369
TP AD+IL ++ IL IPD NAGGVTVS+FEW++N+ Y LE
Sbjct: 402 TPAADKILIDRNILVIPDLYINAGGVTVSFFEWLKNLNHVSYGRLTFKYERESNYHLLES 461
Query: 370 VREKLDKKM-----------TKAFYDVYNTAKEKNI------------------------ 394
V+E L+++ +++F + A EK+I
Sbjct: 462 VQESLERRFGRVGGRIPVTPSESFQKRISGASEKDIVHSGLDYTMERSARAIMKTAMKYN 521
Query: 395 ---HMRDAAYVVAVQRVYQAMLDRG 416
+R AAYV ++++++ D G
Sbjct: 522 LGLDLRTAAYVNSIEKIFTTYRDAG 546
>pir||T28022 hypothetical protein ZK829.4 - Caenorhabditis elegans
>gi|3881823|emb|CAA98074.1| (Z73899) Similarity to
Drosphila Glutamate dehydrogenase (TR:G458803), contains
similarity to Pfam domain: PF00208
(Glutamate/Leucine/Phenylalanine/Valine dehydrogenase),
Score=487.3, E-value=3.8e-143, N=1~cDNA EST EMBL:Z14783
comes from this gene; cDN>
Length = 536
Score = 256 bits (647), Expect = 4e-67
Identities = 143/342 (41%), Positives = 205/342 (59%), Gaps = 13/342 (3%)
Query: 31 LKRPQRIVEVTIPVEMDDGSVKVFTGFRVQYNWARGPTKGGIRWHPEETLSTVKALAAWM 90
+K +++ +T P+ D+G +V +R Q++ R PTKGGIR+ + VKAL+A M
Sbjct: 87 IKPVNKVLYITFPIRRDNGEFEVIEAWRAQHSEHRTPTKGGIRYSLDVCEDEVKALSALM 146
Query: 91 TWKTAVMDLPYGGGKGGIIVDPKKLSDREKERLAR--GYIRAIYDVISPYEDIPAPDVYT 148
T+K AV+D+P+GG KGG+ +DPK+ +D E E++ R A + P D+PAPD+ T
Sbjct: 147 TYKCAVVDVPFGGAKGGVKIDPKQYTDYEIEKITRRIAIEFAKKGFLGPGVDVPAPDMGT 206
Query: 149 NPQIMAWMMDEY-ETIARRKTPAFGIITGKPLSIGGSLGRNEATARGASYTIR------E 201
+ M W+ D Y +TI A ITGKP+ GG GR AT RG + +
Sbjct: 207 GEREMGWIADTYAQTIGHLDRDASACITGKPIVSGGIHGRVSATGRGVWKGLEVFTNDAD 266
Query: 202 AAKVLGWD-DLKGKTIAIQGYGNAGYYLAKIMSEDYGMKVVAVSDSKGGIYNPDGLNADE 260
K++G D L GKT IQG+GN G + + + G KV+ + + +YNPDG++ E
Sbjct: 267 YMKMVGLDTGLAGKTAIIQGFGNVGLHTHRYLHR-AGSKVIGIQEYDCAVYNPDGIHPKE 325
Query: 261 VLKWKREHGSVKDFPGATNITN-EELLELEVDVLAPAAIEEVITKKNADNIKAKIVAEVA 319
+ WK +G++K+FPGA N EL+ + D+ PAA E+ I K+NA I+AKI+AE A
Sbjct: 326 LEDWKDANGTIKNFPGAKNFDPFTELMYEKCDIFVPAACEKSIHKENASRIQAKIIAEAA 385
Query: 320 NGPVTPEADEILFEKG-ILQIPDFLCNAGGVTVSYFEWVQNI 360
NGP TP AD IL +G L IPD N+GGVTVSYFEW++N+
Sbjct: 386 NGPTTPAADRILLARGDCLIIPDMYVNSGGVTVSYFEWLKNL 427
>gb|AAC19750.1| (AF000967) putative glutamate dehydrogenase [Haemonchus contortus]
Length = 538
Score = 254 bits (641), Expect = 2e-66
Identities = 150/388 (38%), Positives = 223/388 (56%), Gaps = 18/388 (4%)
Query: 28 LEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQYNWARGPTKGGIRWHPEETLSTVKALA 87
L+ +K +++ +T P+ D+G +V +R Q++ R PTKGGIR+ + VKAL+
Sbjct: 85 LKAIKPVNKVLYITFPIRRDNGEFEVIEAWRAQHSEHRTPTKGGIRYSMDVCEDEVKALS 144
Query: 88 AWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREKERLAR--GYIRAIYDVISPYEDIPAPD 145
A +T+K A +D+P+GG KGG+ +DPK+ +D E E++ R A + P D+PAPD
Sbjct: 145 ALVTYKCAAVDVPFGGAKGGVKIDPKQYTDYEIEKITRRIAIEFAKKGFLGPGVDVPAPD 204
Query: 146 VYTNPQIMAWMMDEY-ETIARRKTPAFGIITGKPL-SIGGSLGRNEATARGASYTIREAA 203
+ T + M W+ D Y +TI A ITGKP+ S GG GR AT RG +
Sbjct: 205 MGTGEREMGWIADTYAQTIGHLDRDASACITGKPIGSAGGIHGRVSATGRGVWKGLEVFT 264
Query: 204 KVLGWDD-------LKGKTIAIQGYGNAGYYLAKIMSEDYGMKVVAVSDSKGGIYNPDGL 256
K + + L+GKTI IQG+GN G + + + G KV+ V + ++NPDG+
Sbjct: 265 KEPEYSNKVGLSLGLEGKTIIIQGFGNVGLHTMRYLHR-AGAKVIGVQEWDCAVFNPDGI 323
Query: 257 NADEVLKWKREHGSVKDFPGATNITN-EELLELEVDVLAPAAIEEVITKKNADNIKAKIV 315
+ E+ W+ E+G++K+FP A N EL+ D+ PAA E+ I K+NA+ I+AKI+
Sbjct: 324 HPKELEDWRDENGTIKNFPKAKNFEPFAELMYEPCDIFVPAACEKAIHKENANRIQAKII 383
Query: 316 AEVANGPVTPEADEILFEKG-ILQIPDFLCNAGGVTVSYFEWVQNI--TGYYWTLEEVRE 372
AE ANGP TP AD+IL E+G L IPD N+GGVTVSYFEW++N+ Y + E
Sbjct: 384 AEAANGPTTPAADKILLERGNCLIIPDMFINSGGVTVSYFEWLKNLNHVSYGRLSFKYEE 443
Query: 373 KLDKKMTKAFYDVYNTA--KEKNIHMRD 398
++ + ++ D A KE +H D
Sbjct: 444 DSNRMLLQSVQDSLEKALNKEAPVHPND 471
>emb|CAA72173.1| (Y11314) glutamate dehydrogenase (NAD(P)+) [Drosophila
melanogaster]
Length = 562
Score = 253 bits (639), Expect = 3e-66
Identities = 131/337 (38%), Positives = 203/337 (59%), Gaps = 17/337 (5%)
Query: 37 IVEVTIPVEMDDGSVKVFTGFRVQYNWARGPTKGGIRWHPEETLSTVKALAAWMTWKTAV 96
I+E+ P+ D G+ ++ TG+R Q++ + PTKGGIR+ + + VKAL+A MT+K A
Sbjct: 106 IIEIAFPLRRDAGNYEMITGYRAQHSTHKTPTKGGIRFSLDVSRDEVKALSALMTFKCAC 165
Query: 97 MDLPYGGGKGGIIVDPKKLSDREKERLARGYIRAIYD--VISPYEDIPAPDVYTNPQIMA 154
+D+P+GG K G+ ++PK+ S+ E E++ R + + I P D+PAPD+ T + M+
Sbjct: 166 VDVPFGGAKAGLKINPKEYSEHELEKITRRFTLELAKKGFIGPGVDVPAPDMGTGEREMS 225
Query: 155 WMMDEY-ETIARRKTPAFGIITGKPLSIGGSLGRNEATARGASYTIR----------EAA 203
W+ D Y +TI A +TGKP++ GG GR AT RG + + +
Sbjct: 226 WIADTYAKTIGHLDINAHACVTGKPINQGGIHGRVSATGRGVFHGLENFINEANYMSQIG 285
Query: 204 KVLGWDDLKGKTIAIQGYGNAGYYLAKIMSEDYGMKVVAVSDSKGGIYNPDGLNADEVLK 263
GW GKT +QG+GN G + + ++ G + V + G +YNP+G++ +
Sbjct: 286 TTPGWG---GKTFIVQGFGNVGLHTTRYLTRA-GATCIGVIEHDGTLYNPEGIDPKLLED 341
Query: 264 WKREHGSVKDFPGATNITNEELLELEVDVLAPAAIEEVITKKNADNIKAKIVAEVANGPV 323
+K EHG++ + A E L+ + D+ PAA+E+VIT +NA+ I+AKI+AE ANGP
Sbjct: 342 YKNEHGTIVGYQNAKPYEGENLMFEKCDIFIPAAVEKVITSENANRIQAKIIAEAANGPT 401
Query: 324 TPEADEILFEKGILQIPDFLCNAGGVTVSYFEWVQNI 360
TP AD+IL ++ IL IPD NAGGVTVS+FEW++N+
Sbjct: 402 TPAADKILIDRNILVIPDLYINAGGVTVSFFEWLKNL 438
>sp|P00368|DHE3_CHICK GLUTAMATE DEHYDROGENASE (GDH) >gi|66083|pir||DECHE glutamate
dehydrogenase (NAD(P)+) (EC 1.4.1.3) - chicken
(tentative sequence)
Length = 503
Score = 248 bits (627), Expect = 8e-65
Identities = 156/450 (34%), Positives = 234/450 (51%), Gaps = 63/450 (14%)
Query: 28 LEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQYNWARGPTKGGIRWHPEETLSTVKALA 87
L +K ++ V+ P++ DDG +V G+R Q++ R P KGGIR+ + ++ VKALA
Sbjct: 52 LRIIKPCNHVLSVSFPIKRDDGZWEVIEGYRAQHSHQRTPCKGGIRYSLDVSVDEVKALA 111
Query: 88 AWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREKERLARGYIR--AIYDVISPYEDIPAPD 145
+ MT+K AV+D+P+GG K G+ ++PK +D + E++ R + A I P D+PAP+
Sbjct: 112 SLMTYKCAVVDVPFGGAKAGVKINPKNYTDEDLEKITRRFTMELAKKGFIGPGVDVPAPN 171
Query: 146 VYTNPQIMAWMMDEY-ETIARRKTPAFGIITGKPLSIGGSLGRNEATARGASYTIREAAK 204
+ T + M+W+ D Y TI A +T +S GG GR AT RG I +
Sbjct: 172 MSTGEREMSWIADTYASTIGHYDINAHACVTKPGISQGGIHGRISATGRGLFGHIENFIE 231
Query: 205 VLGWDDLKG-------KTIAIQGYGNAGYYLAKIMSEDYGMKVVAVSDSKGGIYNPDGLN 257
+ + G KT A+QG+GN G + + + +G K VAV + G I+NPDG++
Sbjct: 232 NASYMSILGMTPGFGDKTFAVQGFGNVGLHSMRYLHR-FGAKCVAVGEFDGSIWNPDGID 290
Query: 258 ADEVLKWKREHGSVKDFPGATNITNEELLELEVDVLAPAAIEEVITKKNADNIKAKIVAE 317
E+ +K +HG++ FP A + +LE + D+L PAA E+ +TK NA +KAKI+AE
Sbjct: 291 PKELEDYKLQHGTIMGFPKAQKLEG-SILETDCDILIPAASEKQLTKANAHKVKAKIIAE 349
Query: 318 VANGPVTPEADEILFEKGILQIPDFLCNAGGVTVSYFEWVQ-NITGY------------Y 364
ANGP TP+AD+I E+ I+ IPD NAGGVTVS FZ N Y Y
Sbjct: 350 GANGPTTPQADKIFLERNIMVIPDLYLNAGGVTVSAFZZKNLNHVSYGRLTFKYERDSNY 409
Query: 365 WTLEEVREKLDKKM-----------TKAFYDVYNTAKEKNI------------------- 394
L V+E L++K T F D + A EK+I
Sbjct: 410 HLLMSVQESLERKFGKHGGTIPVVPTAEFQDRISGASEKDIVHSGLAYTMERSARQIMRT 469
Query: 395 --------HMRDAAYVVAVQRVYQAMLDRG 416
+R AAYV A+++V++ + G
Sbjct: 470 AMKYNLGLDLRTAAYVNAIEKVFKVYNEAG 499
>gb|AAF56209.2| (AE003745) Gdh gene product [Drosophila melanogaster]
Length = 564
Score = 248 bits (626), Expect = 1e-64
Identities = 131/339 (38%), Positives = 203/339 (59%), Gaps = 19/339 (5%)
Query: 37 IVEVTIPVEMDDGSVKVFTGFRVQYNWARGPTKGG--IRWHPEETLSTVKALAAWMTWKT 94
I+E+ P+ D G+ ++ TG+R Q++ + PTKGG IR+ + + VKAL+A MT+K
Sbjct: 106 IIEIAFPLRRDAGNYEMITGYRAQHSTHKTPTKGGKCIRFSLDVSRDEVKALSALMTFKC 165
Query: 95 AVMDLPYGGGKGGIIVDPKKLSDREKERLARGYIRAIYD--VISPYEDIPAPDVYTNPQI 152
A +D+P+GG K G+ ++PK+ S+ E E++ R + + I P D+PAPD+ T +
Sbjct: 166 ACVDVPFGGAKAGLKINPKEYSEHELEKITRRFTLELAKKGFIGPGVDVPAPDMGTGERE 225
Query: 153 MAWMMDEY-ETIARRKTPAFGIITGKPLSIGGSLGRNEATARGASYTIR----------E 201
M+W+ D Y +TI A +TGKP++ GG GR AT RG + + +
Sbjct: 226 MSWIADTYAKTIGHLDINAHACVTGKPINQGGIHGRVSATGRGVFHGLENFINEANYMSQ 285
Query: 202 AAKVLGWDDLKGKTIAIQGYGNAGYYLAKIMSEDYGMKVVAVSDSKGGIYNPDGLNADEV 261
GW GKT +QG+GN G + + ++ G + V + G +YNP+G++ +
Sbjct: 286 IGTTPGWG---GKTFIVQGFGNVGLHTTRYLTRA-GATCIGVIEHDGTLYNPEGIDPKLL 341
Query: 262 LKWKREHGSVKDFPGATNITNEELLELEVDVLAPAAIEEVITKKNADNIKAKIVAEVANG 321
+K EHG++ + A E L+ + D+ PAA+E+VIT +NA+ I+AKI+AE ANG
Sbjct: 342 EDYKNEHGTIVGYQNAKPYEGENLMFEKCDIFIPAAVEKVITSENANRIQAKIIAEAANG 401
Query: 322 PVTPEADEILFEKGILQIPDFLCNAGGVTVSYFEWVQNI 360
P TP AD+IL ++ IL IPD NAGGVTVS+FEW++N+
Sbjct: 402 PTTPAADKILIDRNILVIPDLYINAGGVTVSFFEWLKNL 440
>sp|Q53199|DHE3_RHISN PROBABLE GLUTAMATE DEHYDROGENASE (GDH) >gi|1486428|emb|CAA92406.1|
(Z68203) glutamate dehydrogenase homologue [Rhizobium
sp.] >gi|2182656|gb|AAB91878.1| (AE000099) Y4uF
[Rhizobium sp. NGR234]
Length = 443
Score = 215 bits (543), Expect = 6e-55
Identities = 139/383 (36%), Positives = 206/383 (53%), Gaps = 23/383 (6%)
Query: 34 PQRIVEVTIPVEMD-----DGSVKVFTGFRVQYNWARGPTKGGIRWHPEETLSTVKALAA 88
P+RI++ P + G + F G+R P KG IR+ V+ALAA
Sbjct: 11 PERIIQCNSPYTVRFGVRLRGRMYSFIGWRSVREHCE-PVKGDIRYASNADAEEVEALAA 69
Query: 89 WMTWKTAVMDLPYGGGKGGIIVDPKKLSDREKERLARGYIRAIYDVIS-PYEDIPAPDVY 147
MT K +++D+P+GG KG + +DP+ + +E E + R + + + D+
Sbjct: 70 LMTLKCSLVDVPFGGSKGALKIDPRGWTPQELEHITRRFTQEMNKRPDRARRQCVGSDIG 129
Query: 148 TNPQIMAWMMDEYETIARRKTPAFGI-----ITGKPLSIGGSLGRNEATARGASYTIREA 202
T + MAWMMDE+ RR P + +TGKPLS GG GR E+T RG + I+ +
Sbjct: 130 TGEREMAWMMDEF----RRANPTDVVTSGACVTGKPLSKGGIAGRAESTGRGVQFAIQSS 185
Query: 203 AK------VLGWDDLKGKTIAIQGYGNAGYYLAKIMSEDYGMKVVAVSDSKGGIYNPDGL 256
+ + G +LKG + IQG+GN GY+ A+ +SE+ +V +++ G + NP+GL
Sbjct: 186 LRDTRTPGLDGRRNLKGASTVIQGFGNVGYHAARFLSEEDDARVTVLAERDGYVANPEGL 245
Query: 257 NADEVLKWKREHGSVKDFPGATNITNEEL-LELEVDVLAPAAIEEVITKKNADNIKAKIV 315
+ + + + + GS+ F GA +I + +E DVL PAA+E I +NA+ +KA +V
Sbjct: 246 SIEALKQHQIRTGSILGFDGAKSIAGDMCGVEQPCDVLIPAAMENAIHAENAERMKAHLV 305
Query: 316 AEVANGPVTPEADEILFEKGILQIPDFLCNAGGVTVSYFEWVQNITGYYWTLEEVREKLD 375
E ANGPVT EADEIL +G+ +PD NAGGV VSYFE V+N+T + L E R +
Sbjct: 306 VEAANGPVTFEADEILRSRGVTILPDLYVNAGGVVVSYFERVKNLTHIPFGLMERRRRER 365
Query: 376 KKMTKAFYDVYNTAKEKNIHMRD 398
T A T KE MRD
Sbjct: 366 GNHTIATALERMTGKESPADMRD 388
>sp|P24295|DHE2_CLOSY NAD-SPECIFIC GLUTAMATE DEHYDROGENASE (NAD-GDH)
>gi|98634|pir||S22403 glutamate dehydrogenase (EC
1.4.1.2) - Clostridium symbiosum
>gi|49280|emb|CAA77805.1| (Z11747) Glutamate
Dehydrogenase [Clostridium symbiosum]
Length = 450
Score = 209 bits (527), Expect = 4e-53
Identities = 146/406 (35%), Positives = 211/406 (51%), Gaps = 24/406 (5%)
Query: 28 LEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQYNWARGPTKGGIRWHPEETLSTVKALA 87
LE + P+R++E +P E D+G V V TG+RVQ+N A GP KGG+R+ P LS +K L
Sbjct: 49 LERMVIPERVIEFRVPWEDDNGKVHVNTGYRVQFNGAIGPYKGGLRFAPSVNLSIMKFLG 108
Query: 88 AWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREKERLARGYIRAIYDVISPYEDIPAPDVY 147
+K ++ LP GG KGG DP SDRE R + ++ +Y I P D+PA D+
Sbjct: 109 FEQAFKDSLTTLPMGGAKGGSDFDPNGKSDREVMRFCQAFMTELYRHIGPDIDVPAGDLG 168
Query: 148 TNPQIMAWMMDEYETIARRKTPAF--GIITGKPLSIGGSLGRNEATARGASYTIREAAKV 205
+ + +M +Y R+ F G++TGK S GGSL R EAT G+ Y + EA
Sbjct: 169 VGAREIGYMYGQY----RKIVGGFYNGVLTGKARSFGGSLVRPEATGYGSVYYV-EAVMK 223
Query: 206 LGWDDLKGKTIAIQGYGNAGYYLAKIMSEDYGMKVVAVSDSKGGIYNPDGLNADEVLKWK 265
D L GKT+A+ G+GN + AK ++E G K V +S G IY+P+G+ +E + +
Sbjct: 224 HENDTLVGKTVALAGFGNVAWGAAKKLAE-LGAKAVTLSGPDGYIYDPEGITTEEKINYM 282
Query: 266 RE-----HGSVKDFP---GATNITNEELLELEVDVLAPAAIEEVITKKNADNIKA---KI 314
E V+D+ G E+ +VD++ P A + + + A I A K
Sbjct: 283 LEMRASGRNKVQDYADKFGVQFFPGEKPWGQKVDIIMPCATQNDVDLEQAKKIVANNVKY 342
Query: 315 VAEVANGPVTPEADEILFEK-GILQIPDFLCNAGGVTVSYFEWVQNITGYYWTLEEVREK 373
EVAN P T EA L ++ ++ P NAGGV VS FE QN WT EEV K
Sbjct: 343 YIEVANMPTTNEALRFLMQQPNMVVAPSKAVNAGGVLVSGFEMSQNSERLSWTAEEVDSK 402
Query: 374 LDKKMTKAFYDVYNTAKEK---NIHMRDAAYVVAVQRVYQAMLDRG 416
L + MT +D A E+ ++ A +V Q++ AM+ +G
Sbjct: 403 LHQVMTD-IHDGSAAAAERYGLGYNLVAGANIVGFQKIADAMMAQG 447
>pdb|1BGV|A Chain A, Glutamate Dehydrogenase >gi|1942184|pdb|1HRD|A Chain A,
Glutamate Dehydrogenase >gi|1942185|pdb|1HRD|B Chain B,
Glutamate Dehydrogenase >gi|1942186|pdb|1HRD|C Chain C,
Glutamate Dehydrogenase
Length = 449
Score = 209 bits (527), Expect = 4e-53
Identities = 146/406 (35%), Positives = 211/406 (51%), Gaps = 24/406 (5%)
Query: 28 LEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQYNWARGPTKGGIRWHPEETLSTVKALA 87
LE + P+R++E +P E D+G V V TG+RVQ+N A GP KGG+R+ P LS +K L
Sbjct: 48 LERMVIPERVIEFRVPWEDDNGKVHVNTGYRVQFNGAIGPYKGGLRFAPSVNLSIMKFLG 107
Query: 88 AWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREKERLARGYIRAIYDVISPYEDIPAPDVY 147
+K ++ LP GG KGG DP SDRE R + ++ +Y I P D+PA D+
Sbjct: 108 FEQAFKDSLTTLPMGGAKGGSDFDPNGKSDREVMRFCQAFMTELYRHIGPDIDVPAGDLG 167
Query: 148 TNPQIMAWMMDEYETIARRKTPAF--GIITGKPLSIGGSLGRNEATARGASYTIREAAKV 205
+ + +M +Y R+ F G++TGK S GGSL R EAT G+ Y + EA
Sbjct: 168 VGAREIGYMYGQY----RKIVGGFYNGVLTGKARSFGGSLVRPEATGYGSVYYV-EAVMK 222
Query: 206 LGWDDLKGKTIAIQGYGNAGYYLAKIMSEDYGMKVVAVSDSKGGIYNPDGLNADEVLKWK 265
D L GKT+A+ G+GN + AK ++E G K V +S G IY+P+G+ +E + +
Sbjct: 223 HENDTLVGKTVALAGFGNVAWGAAKKLAE-LGAKAVTLSGPDGYIYDPEGITTEEKINYM 281
Query: 266 RE-----HGSVKDFP---GATNITNEELLELEVDVLAPAAIEEVITKKNADNIKA---KI 314
E V+D+ G E+ +VD++ P A + + + A I A K
Sbjct: 282 LEMRASGRNKVQDYADKFGVQFFPGEKPWGQKVDIIMPCATQNDVDLEQAKKIVANNVKY 341
Query: 315 VAEVANGPVTPEADEILFEK-GILQIPDFLCNAGGVTVSYFEWVQNITGYYWTLEEVREK 373
EVAN P T EA L ++ ++ P NAGGV VS FE QN WT EEV K
Sbjct: 342 YIEVANMPTTNEALRFLMQQPNMVVAPSKAVNAGGVLVSGFEMSQNSERLSWTAEEVDSK 401
Query: 374 LDKKMTKAFYDVYNTAKEK---NIHMRDAAYVVAVQRVYQAMLDRG 416
L + MT +D A E+ ++ A +V Q++ AM+ +G
Sbjct: 402 LHQVMTD-IHDGSAAAAERYGLGYNLVAGANIVGFQKIADAMMAQG 446
>gb|AAF15393.1|AF109176_1 (AF109176) NAD dependent glutamate dehydrogenase 1 [Entodinium
caudatum] >gi|6531393|gb|AAF15394.1|AF109177_1
(AF109177) NAD dependent glutamate dehydrogenase 2
[Entodinium caudatum]
Length = 438
Score = 209 bits (526), Expect = 6e-53
Identities = 139/408 (34%), Positives = 207/408 (50%), Gaps = 18/408 (4%)
Query: 23 ISEEALEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQYNWARGPTKGGIRWHPEETLST 82
+ + LE + P I E + E D + V G+R+Q+N A GP KGG+R+H TL T
Sbjct: 36 LENKILERITEPNLIHEFKVEWENDKHEIMVNKGYRIQFNNAIGPYKGGLRFHRAVTLGT 95
Query: 83 VKALAAWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREKERLARGYIRAIYDVISPYEDIP 142
+K L +K ++ LP GGGKGG DP+ SD E R R ++ +++ I P D+P
Sbjct: 96 LKFLGFEQIFKNSLTGLPMGGGKGGSDFDPRGKSDAEILRFCRSFMTSLFKYIGPEIDVP 155
Query: 143 APDVYTNPQIMAWMMDEYETIARRKTPAFGIITGKPLSIGGSLGRNEATARGASYTIREA 202
A D+ + + ++ +Y+ + ++ G++TGK L+ GGSL R EAT G Y E
Sbjct: 156 AGDIGVGGREIGYLFGQYKRLTQQHE---GVLTGKGLNWGGSLVRPEATGFGTMYFANEV 212
Query: 203 AKVLGWDDLKGKTIAIQGYGNAGYYLAKIMSEDYGMKVVAVSDSKGGIYNPDGLNADEVL 262
G DD+KGKTIAI G+GN + A + ++ G KVV +S G IY+ +G+N DE +
Sbjct: 213 LHAHG-DDIKGKTIAISGFGNVAFG-AVLKAKQLGAKVVTISGPDGYIYDENGINTDEKI 270
Query: 263 KWKRE-----HGSVKDFP---GATNITNEELLELEVDVLAPAAIEEVITKKNADNIK--- 311
+ E + V F GA I ++ E+ VD+ P AI+ + ++A +
Sbjct: 271 NYMLELRASNNDVVAPFAEKFGAKFIPGKKPWEVPVDMAFPCAIQNELNAEDAATLHKNG 330
Query: 312 AKIVAEVANGPVTPEADEILFEKGILQIPDFLCNAGGVTVSYFEWVQNITGYYWTLEEVR 371
K V E +N T +A + + I+ P NAGGV VS E QN WT EEV
Sbjct: 331 VKYVIETSNMGCTADAVQYFIKNRIVFAPGKAANAGGVAVSGLEMSQNSMKLNWTAEEVD 390
Query: 372 EKLDKKMTKAFYDVYNTAKEKN--IHMRDAAYVVAVQRVYQAMLDRGW 417
KL MT KE + I+ A + ++V AM+D G+
Sbjct: 391 AKLKNIMTNIHASCVKEGKESDGYINYVKGANIAGFKKVADAMVDLGY 438
>pdb|1K89| K89l Mutant Of Glutamate Dehydrogenase
Length = 449
Score = 207 bits (521), Expect = 2e-52
Identities = 145/406 (35%), Positives = 210/406 (51%), Gaps = 24/406 (5%)
Query: 28 LEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQYNWARGPTKGGIRWHPEETLSTVKALA 87
LE + P+R++E +P E D+G V V TG+RVQ+N A GP GG+R+ P LS +K L
Sbjct: 48 LERMVIPERVIEFRVPWEDDNGKVHVNTGYRVQFNGAIGPYLGGLRFAPSVNLSIMKFLG 107
Query: 88 AWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREKERLARGYIRAIYDVISPYEDIPAPDVY 147
+K ++ LP GG KGG DP SDRE R + ++ +Y I P D+PA D+
Sbjct: 108 FEQAFKDSLTTLPMGGAKGGSDFDPNGKSDREVMRFCQAFMTELYRHIGPDIDVPAGDLG 167
Query: 148 TNPQIMAWMMDEYETIARRKTPAF--GIITGKPLSIGGSLGRNEATARGASYTIREAAKV 205
+ + +M +Y R+ F G++TGK S GGSL R EAT G+ Y + EA
Sbjct: 168 VGARELGYMYGQY----RKIVGGFYNGVLTGKARSFGGSLVRPEATGYGSVYYV-EAVMK 222
Query: 206 LGWDDLKGKTIAIQGYGNAGYYLAKIMSEDYGMKVVAVSDSKGGIYNPDGLNADEVLKWK 265
D L GKT+A+ G+GN + AK ++E G K V +S G IY+P+G+ +E + +
Sbjct: 223 HENDTLVGKTVALAGFGNVAWGAAKKLAE-LGAKAVTLSGPDGYIYDPEGITTEEKINYM 281
Query: 266 RE-----HGSVKDFP---GATNITNEELLELEVDVLAPAAIEEVITKKNADNIKA---KI 314
E V+D+ G E+ +VD++ P A + + + A I A K
Sbjct: 282 LEMRASGRNKVQDYADKFGVQFFPGEKPWGQKVDIIMPCATQNDVDLEQAKKIVANNVKY 341
Query: 315 VAEVANGPVTPEADEILFEK-GILQIPDFLCNAGGVTVSYFEWVQNITGYYWTLEEVREK 373
EVAN P T EA L ++ ++ P NAGGV VS FE QN WT EEV K
Sbjct: 342 YIEVANMPTTNEALRFLMQQPNMVVAPSKAVNAGGVLVSGFEMSQNSERLSWTAEEVDSK 401
Query: 374 LDKKMTKAFYDVYNTAKEK---NIHMRDAAYVVAVQRVYQAMLDRG 416
L + MT +D A E+ ++ A +V Q++ AM+ +G
Sbjct: 402 LHQVMTD-IHDGSAAAAERYGLGYNLVAGANIVGFQKIADAMMAQG 446
>emb|CAA41635.1| (X58831) glutamate dehydrogenase (NADP+) [Chlorella sorokiniana]
Length = 523
Score = 206 bits (520), Expect = 3e-52
Identities = 143/433 (33%), Positives = 221/433 (51%), Gaps = 22/433 (5%)
Query: 3 EQDPFEIAVKQLERAAQ-YMKISEEALEFLKR---PQRIVEVTIPVEMDDGSVKVFTGFR 58
EQ F AV+++ + Q + E L K+ P+R++ + D G+++V GFR
Sbjct: 96 EQQEFMQAVREVAVSLQPVFEKRPELLPIFKQIVEPERVITFRVSWLDDAGNLQVNRGFR 155
Query: 59 VQYNWARGPTKGGIRWHPEETLSTVKALAAWMTWKTAVMDLPYGGGKGGIIVDPKKLSDR 118
VQY+ A GP KGG+R+HP LS +K LA +K ++ LP GGGKGG DPK SD
Sbjct: 156 VQYSSAIGPYKGGLRFHPSVNLSIMKFLAFEQIFKNSLTTLPMGGGKGGSDFDPKGKSDA 215
Query: 119 EKERLARGYIRAIYDVISPYEDIPAPDVYTNPQIMAWMMDEYETIARRKTPAFGIITGKP 178
E RL + ++ + IS +D+PA D+ + + ++ +Y+ I + T G++TGK
Sbjct: 216 EVMRLWQSFMTELQRHISYVQDVPAGDIGVGAREIGYLFGQYKRITKNYT---GVLTGKG 272
Query: 179 LSIGGSLGRNEATARGASYTIREAAKVLGWDDLKGKTIAIQGYGNAGYYLAKIMSEDYGM 238
GGS R EAT GA + K G + LKGK + G GN Y A+++ E G
Sbjct: 273 QEYGGSEIRPEATGYGAVLFVENVLKDKG-ESLKGKRCLVSGAGNVAQYCAELLLEK-GA 330
Query: 239 KVVAVSDSKGGIYNPDG-----LNADEVLKWKREHGSVKDFPGATNITNEEL-----LEL 288
V+++SDS+G +Y P+G L A + +K K + ++ T + + L+
Sbjct: 331 IVLSLSDSQGYVYEPNGFTREQLQAVQDMKKKNNSARISEYKSDTAVYVGDRRKPWELDC 390
Query: 289 EVDVLAPAAIEEVITKKNADNI---KAKIVAEVANGPVTPEADEILFEKGILQIPDFLCN 345
+VD+ P A + I + +A+ + + V E AN P T EA + GI+ P N
Sbjct: 391 QVDIAFPCATQNEIDEHDAELLIKHGCQYVVEGANMPSTNEAIHKYNKAGIIYCPGKAAN 450
Query: 346 AGGVTVSYFEWVQNITGYYWTLEEVREKLDKKMTKAFYDVYNTAKEKNIHMRDAAYVVAV 405
AGGV VS E QN WT EEVR+KL++ M + ++E N+ + A +
Sbjct: 451 AGGVAVSGLEMTQNRMSLNWTREEVRDKLERIMKDIYDSAMGPSREYNVDLAAGANIAGF 510
Query: 406 QRVYQAMLDRGWV 418
+V A+ +G V
Sbjct: 511 TKVADAVKAQGAV 523
>sp|P28998|DHE4_CHLSO NADP-SPECIFIC GLUTAMATE DEHYDROGENASE (NADP-GDH)
>gi|81298|pir||S17949 glutamate dehydrogenase (NADP+)
(EC 1.4.1.4) precursor - Chlorella sorokiniana
(fragment) >gi|18273|emb|CAA41636.1| (X58832) glutamate
dehydrogenase (NADP+) [Chlorella sorokiniana]
Length = 523
Score = 206 bits (519), Expect = 4e-52
Identities = 142/433 (32%), Positives = 220/433 (50%), Gaps = 22/433 (5%)
Query: 3 EQDPFEIAVKQLERAAQ-YMKISEEALEFLKR---PQRIVEVTIPVEMDDGSVKVFTGFR 58
EQ F AV+++ + Q + E L K+ P+R++ + D G+++V GFR
Sbjct: 96 EQQEFMQAVREVAVSLQPVFEKRPELLPIFKQIVEPERVITFRVSWLDDAGNLQVNRGFR 155
Query: 59 VQYNWARGPTKGGIRWHPEETLSTVKALAAWMTWKTAVMDLPYGGGKGGIIVDPKKLSDR 118
VQY+ A GP KGG+R+HP LS +K LA +K ++ LP GGGKGG DPK SD
Sbjct: 156 VQYSSAIGPYKGGLRFHPSVNLSIMKFLAFEQIFKNSLTTLPMGGGKGGSDFDPKGKSDA 215
Query: 119 EKERLARGYIRAIYDVISPYEDIPAPDVYTNPQIMAWMMDEYETIARRKTPAFGIITGKP 178
E R + ++ + IS +D+PA D+ + + ++ +Y+ I + T G++TGK
Sbjct: 216 EVMRFCQSFMTELQRHISYVQDVPAGDIGVGAREIGYLFGQYKRITKNYT---GVLTGKG 272
Query: 179 LSIGGSLGRNEATARGASYTIREAAKVLGWDDLKGKTIAIQGYGNAGYYLAKIMSEDYGM 238
GGS R EAT GA + K G + LKGK + G GN Y A+++ E G
Sbjct: 273 QEYGGSEIRPEATGYGAVLFVENVLKDKG-ESLKGKRCLVSGAGNVAQYCAELLLEK-GA 330
Query: 239 KVVAVSDSKGGIYNPDG-----LNADEVLKWKREHGSVKDFPGATNITNEEL-----LEL 288
V+++SDS+G +Y P+G L A + +K K + ++ T + + L+
Sbjct: 331 IVLSLSDSQGYVYEPNGFTREQLQAVQDMKKKNNSARISEYKSDTAVYVGDRRKPWELDC 390
Query: 289 EVDVLAPAAIEEVITKKNADNI---KAKIVAEVANGPVTPEADEILFEKGILQIPDFLCN 345
+VD+ P A + I + +A+ + + V E AN P T EA + GI+ P N
Sbjct: 391 QVDIAFPCATQNEIDEHDAELLIKHGCQYVVEGANMPSTNEAIHKYNKAGIIYCPGKAAN 450
Query: 346 AGGVTVSYFEWVQNITGYYWTLEEVREKLDKKMTKAFYDVYNTAKEKNIHMRDAAYVVAV 405
AGGV VS E QN WT EEVR+KL++ M + ++E N+ + A +
Sbjct: 451 AGGVAVSGLEMTQNRMSLNWTREEVRDKLERIMKDIYDSAMGPSREYNVDLAAGANIAGF 510
Query: 406 QRVYQAMLDRGWV 418
+V A+ +G V
Sbjct: 511 TKVADAVKAQGAV 523
>pir||S32227 glutamate dehydrogenase (NADP+) (EC 1.4.1.4) - Corynebacterium
glutamicum (ssp. melassecola ATCC 17965)
>gi|288413|emb|CAA51376.1| (X72855) glutamate
dehydrogenase (NADP+) [Corynebacterium glutamicum]
Length = 447
Score = 206 bits (518), Expect = 5e-52
Identities = 137/400 (34%), Positives = 202/400 (50%), Gaps = 16/400 (4%)
Query: 28 LEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQYNWARGPTKGGIRWHPEETLSTVKALA 87
++ L P+R + +P D G V V GFRVQ+N A GP KGG+R+HP L VK L
Sbjct: 51 IQRLCEPERQLIFRVPWVDDQGQVHVNRGFRVQFNSALGPYKGGLRFHPSVNLGIVKFLG 110
Query: 88 AWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREKERLARGYIRAIYDVISPYEDIPAPDVY 147
+K ++ LP GGGKGG DPK SD E R + ++ ++ I Y D+PA D+
Sbjct: 111 FEQIFKNSLTGLPIGGGKGGSDFDPKGKSDLEIMRFCQSFMTELHRHIGEYRDVPAGDIG 170
Query: 148 TNPQIMAWMMDEYETIARRKTPAFGIITGKPLSIGGSLGRNEATARGASYTIREAAKVLG 207
+ + ++ Y +A + G++TGK L+ GGSL R EAT G Y + E K G
Sbjct: 171 VGGREIGYLFGHYRRMANQHES--GVLTGKGLTWGGSLVRTEATGYGCVYFVSEMIKAKG 228
Query: 208 WDDLKGKTIAIQGYGNAGYYLAKIMSEDYGMKVVAVSDSKGGIYNPDGLNA---DEVLKW 264
+ + G+ I + G GN Y + +++ G V+ SDS G ++ P+G++ E+ +
Sbjct: 229 -ESISGQKIIVSGSGNVATYAIE-KAQELGATVIGFSDSSGWVHTPNGVDVAKLREIKEV 286
Query: 265 KREHGSV--KDFPGATNITNEELLELEVDVLAPAAIEEVITKKNADNIK---AKIVAEVA 319
+R SV + GAT T+ + +L+ D+ P A + + +NA + + VAE A
Sbjct: 287 RRARVSVYADEVEGATYHTDGSIWDLKCDIALPCATQNELNGENAKTLADNGCRFVAEGA 346
Query: 320 NGPVTPEADEILFEKGILQIPDFLCNAGGVTVSYFEWVQNITGYYWTLEEVREKLDKKMT 379
N P TPEA E+ E+ I P NAGGV S E QN + W+ E E+L M
Sbjct: 347 NMPSTPEAVEVFRERDIRFGPGKAANAGGVATSALEMQQNASRDSWSFEYTDERLQVIMK 406
Query: 380 KAFYDVYNTAKEKNIHMRD---AAYVVAVQRVYQAMLDRG 416
F TA E H D A + ++V AML +G
Sbjct: 407 NIFKTCAETAAEYG-HENDYVVGANIAGFKKVADAMLAQG 445
>pdb|1AUP| Glutamate Dehydrogenase
Length = 449
Score = 204 bits (514), Expect = 1e-51
Identities = 144/406 (35%), Positives = 209/406 (51%), Gaps = 24/406 (5%)
Query: 28 LEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQYNWARGPTKGGIRWHPEETLSTVKALA 87
LE + P+R++E +P E D+G V V TG+RVQ+N A GP GG+R+ P LS +K L
Sbjct: 48 LERMVIPERVIEFRVPWEDDNGKVHVNTGYRVQFNGAIGPYLGGLRFAPSVNLSIMKFLG 107
Query: 88 AWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREKERLARGYIRAIYDVISPYEDIPAPDVY 147
+K ++ LP GG KGG DP SDRE R + ++ +Y I P D+PA D+
Sbjct: 108 FEQAFKDSLTTLPMGGAKGGSDFDPNGKSDREVMRFCQAFMTELYRHIGPDIDVPAGDLG 167
Query: 148 TNPQIMAWMMDEYETIARRKTPAF--GIITGKPLSIGGSLGRNEATARGASYTIREAAKV 205
+ + +M +Y R+ F G++TGK S GGSL R EAT G+ Y + EA
Sbjct: 168 VGAREIGYMYGQY----RKIVGGFYNGVLTGKARSFGGSLVRPEATGYGSVYYV-EAVMK 222
Query: 206 LGWDDLKGKTIAIQGYGNAGYYLAKIMSEDYGMKVVAVSDSKGGIYNPDGLNADEVLKWK 265
D L GKT+A+ G+GN + AK ++E G K V +S G IY+P+G+ +E + +
Sbjct: 223 HENDTLVGKTVALAGFGNVAWGAAKKLAE-LGAKAVTLSGPDGYIYDPEGITTEEKINYM 281
Query: 266 RE-----HGSVKDFP---GATNITNEELLELEVDVLAPAAIEEVITKKNADNIKA---KI 314
E V+D+ G E+ +VD++ P A + + + A I A K
Sbjct: 282 LEMRASGRNKVQDYADKFGVQFFPGEKPWGQKVDIIMPCATQNDVDLEQAKKIVANNVKY 341
Query: 315 VAEVANGPVTPEADEILFEK-GILQIPDFLCNAGGVTVSYFEWVQNITGYYWTLEEVREK 373
EVAN P T EA L ++ ++ P NAGGV V FE QN WT EEV K
Sbjct: 342 YIEVANMPTTNEALRFLMQQPNMVVAPSKAVNAGGVLVVGFEMSQNSERLSWTAEEVDSK 401
Query: 374 LDKKMTKAFYDVYNTAKEK---NIHMRDAAYVVAVQRVYQAMLDRG 416
L + MT +D A E+ ++ A +V Q++ AM+ +G
Sbjct: 402 LHQVMTD-IHDGSAAAAERYGLGYNLVAGANIVGFQKIADAMMAQG 446
>dbj|BAB05820.1| (AP001514) NADP-specific glutamate dehydrogenase [Bacillus
halodurans]
Length = 458
Score = 203 bits (512), Expect = 2e-51
Identities = 142/426 (33%), Positives = 213/426 (49%), Gaps = 17/426 (3%)
Query: 4 QDPFEIAVKQLERAAQYMKISEEALEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQYNW 63
++ F+ + L + QY+K + LE + P+R++ +P D G+V+V GFRVQ+N
Sbjct: 39 KEVFDSLLPVLVKHPQYVK--QAILERIVEPERVISFRVPWVDDQGNVQVNRGFRVQFNS 96
Query: 64 ARGPTKGGIRWHPEETLSTVKALAAWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREKERL 123
A GP KGG+R+HP S +K L +K A+ P GGGKGG DPK SD E R
Sbjct: 97 ALGPYKGGLRFHPSVNASIIKFLGFEQIFKNALTGQPIGGGKGGSDFDPKGKSDGEIMRF 156
Query: 124 ARGYIRAIYDVISPYEDIPAPDVYTNPQIMAWMMDEYETIARRKTPAFGIITGKPLSIGG 183
++ ++ + + I P D+PA D+ + + +M +Y+ + R G++TGK + GG
Sbjct: 157 SQSFMSELSNYIGPDIDVPAGDIGVGAKEIGYMFGQYKKM--RGGFEAGVLTGKGIGYGG 214
Query: 184 SLGRNEATARGASYTIREAAKVLGWDDLKGKTIAIQGYGNAGYYLAKIMSEDYGMKVVAV 243
SL R EAT G Y + E K G+ G T+ + G GN Y A + G KVVA
Sbjct: 215 SLARKEATGYGTVYFVEEMIKDHGF-SFAGSTVVVSGSGNVSIY-AMEKAMQLGAKVVAC 272
Query: 244 SDSKGGIYNPDGLNADEV-----LKWKREHGSVKDFPGATNITN-EELLELEVDVLAPAA 297
SDS G +Y+ +G++ V ++ KR V + P A + + + D+ P A
Sbjct: 273 SDSGGYVYDKNGIDLQTVKRLKEVERKRISEYVNEHPHAHYVQGCSGIWSVPCDIALPCA 332
Query: 298 IEEVITKKNADNIKA---KIVAEVANGPVTPEADEILFEKGILQIPDFLCNAGGVTVSYF 354
+ + + A + A K V E AN P T +A E G+L P NAGGV+VS
Sbjct: 333 TQNELDEAAATMLIANGVKAVGEGANMPSTLQAVHTFQEHGVLFAPAKAANAGGVSVSAL 392
Query: 355 EWVQNITGYYWTLEEVREKLDKKMTKAFYDVYNTAK--EKNIHMRDAAYVVAVQRVYQAM 412
E QN T WT EEV KL + M + + A+ E + ++ A + +V AM
Sbjct: 393 EMAQNSTRLAWTFEEVDAKLYEIMKNIYRESIKAAELYEASGNLVVGANIAGFVKVADAM 452
Query: 413 LDRGWV 418
+ G V
Sbjct: 453 ISHGVV 458
>sp|P95544|DHE4_PRERU NADP-SPECIFIC GLUTAMATE DEHYDROGENASE (NADP-GDH) (NAD(P)H-DEPENDENT
GLUTAMATE DEHYDROGENASE) >gi|7431777|pir||T10487
glutamate dehydrogenase (NADP+) (EC 1.4.1.4) -
Prevotella ruminicola >gi|1772845|gb|AAB40142.1|
(U82240) NAD(P)H-dependent glutamate dehydrogenase
[Prevotella bryantii]
Length = 444
Score = 203 bits (511), Expect = 3e-51
Identities = 138/402 (34%), Positives = 208/402 (51%), Gaps = 19/402 (4%)
Query: 28 LEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQYNWARGPTKGGIRWHPEETLSTVKALA 87
+E L P RI++ + D+G+V+ G+RVQ+N A GP KGG+R+H S +K LA
Sbjct: 47 IERLCVPDRILQFRVSWVDDNGNVQTNLGYRVQHNNAIGPYKGGLRFHKSVNASILKFLA 106
Query: 88 AWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREKERLARGYIRAIYDVISPYEDIPAPDVY 147
T+K ++ LP GG KGG DP SD E R + ++ +Y +I P ED+PA D+
Sbjct: 107 FEQTFKNSLTTLPMGGAKGGSDFDPHGKSDMEVMRFCQAFMNELYRLIGPDEDVPAGDIG 166
Query: 148 TNPQIMAWMMDEYETIARRKTPAFGIITGKPLSIGGSLGRNEATARGASYTIREAAKVLG 207
+ + +M +Y+ + + GI+TGK L GGSL R EAT G Y + + K G
Sbjct: 167 VGGREVGYMFGQYKKLTHQFQ---GILTGKGLEFGGSLIRPEATGYGNVYFLEDMLKTRG 223
Query: 208 WDDLKGKTIAIQGYGN-AGYYLAKIMSEDYGMKVVAVSDSKGGIYNPDGLNADE---VLK 263
+ L+GKT+ + G GN A Y + K++ G K V SDS G IY+PDG++A++ +++
Sbjct: 224 -ESLEGKTVLVSGSGNVAQYTIEKLL--QLGAKPVTCSDSNGYIYDPDGIDAEKLAFIME 280
Query: 264 WKR-EHGSVKDFP---GATNITNEELLELEVDVLAPAAIEEVITKKNADNIKAK---IVA 316
K + G +K++ G + N + D+ P A ++ I + A + A V+
Sbjct: 281 LKNVKRGRIKEYAEKYGVKYVENARPWGEKADIATPCATQDEINEAEAKTLIANGVFAVS 340
Query: 317 EVANGPVTPEADEILFEKGILQIPDFLCNAGGVTVSYFEWVQNITGYYWTLEEVREKLDK 376
E AN P P A ++ + IL P NAGGV S E QN WT EEV KL
Sbjct: 341 EGANMPTEPAAIKVFQDAKILYCPGKASNAGGVATSGLEMSQNSERLSWTREEVDTKLHN 400
Query: 377 KMTKAFYDV--YNTAKEKNIHMRDAAYVVAVQRVYQAMLDRG 416
M + + Y T + I+ A V +V +AM+ +G
Sbjct: 401 IMDEIHANCVKYGTEPDGYINYVKGANVAGFMKVAKAMMAQG 442
>gb|AAC63990.1| (AF056335) NADP-specific glutamate dehydrogenase [Bacillus
licheniformis] >gi|3822407|gb|AAC69873.1| (AF092086)
NADP-specific glutamate dehydrogenase [Bacillus
licheniformis]
Length = 460
Score = 203 bits (510), Expect = 4e-51
Identities = 143/428 (33%), Positives = 205/428 (47%), Gaps = 27/428 (6%)
Query: 7 FEIAVKQLERAAQYMKISEEALEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQYNWARG 66
F+ V L R +Y I LE + P+R++ +P D+G+++V G+RVQ+N A G
Sbjct: 44 FDSLVPVLARHPKY--IEHRILERIAEPERMITFRVPWVDDEGNIQVNRGYRVQFNSAIG 101
Query: 67 PTKGGIRWHPEETLSTVKALAAWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREKERLARG 126
P KGGIR+HP S +K L +K ++ P GGGKGG DPK SDRE +
Sbjct: 102 PYKGGIRFHPSVNASIIKFLGFEQIFKNSLTGQPIGGGKGGADFDPKGKSDREIMSFTQS 161
Query: 127 YIRAIYDVISPYEDIPAPDVYTNPQIMAWMMDEYETIARRKTPAFGIITGKPLSIGGSLG 186
++ +Y I P DIPA D+ + + +M +Y+ I R G++TGK L GGSL
Sbjct: 162 FMNELYRHIGPDTDIPAGDIGVGAREVGFMFGQYKKIRGRYDA--GVLTGKGLEYGGSLT 219
Query: 187 RNEATARGASYTIREAAKVLGWDDLKGKTIAIQGYGNAGYYLAKIMSEDYGMKVVAVSDS 246
R EAT G Y + E K G + T+ + G GN Y A + +G KVVA SDS
Sbjct: 220 RKEATGYGLVYFVEEMLKDQGL-RFENSTVVVSGSGNVALY-AMEKAAQFGGKVVACSDS 277
Query: 247 KGGIYNPDGLNADEVLKWKR-----------EHGSVKDFPGATNITNEELLELEVDVLAP 295
G +Y+ G++ + V + K EH F G + I + + D+ P
Sbjct: 278 DGYVYDEKGISLETVKRLKESGNGRIREYVSEHPEAHYFEGCSGIWS-----IPCDIALP 332
Query: 296 AAIEEVITKKNADNI---KAKIVAEVANGPVTPEADEILFEKGILQIPDFLCNAGGVTVS 352
A + I ++ A + K V E AN P A + + G+L P NAGGV VS
Sbjct: 333 CATQNEIDEEAAGVLISNGVKAVGEGANMPSEEGAVKRFLDAGVLFGPAKAANAGGVAVS 392
Query: 353 YFEWVQNITGYYWTLEEVREKLDKKMTKAFYDVYNTAKE--KNIHMRDAAYVVAVQRVYQ 410
E QN +WT EE EKL MT + A E + ++ D + +V
Sbjct: 393 ALEMAQNSARLHWTAEETDEKLRMIMTDIYKRSVEAASEYGRPGNLLDGCNIAGFIKVAD 452
Query: 411 AMLDRGWV 418
AM+ +G V
Sbjct: 453 AMIAQGVV 460
>sp|Q03578|DHE2_PORGI NAD-SPECIFIC GLUTAMATE DEHYDROGENASE (NAD-GDH) (SURFACE-ASSOCIATED
PROTEIN PGAG1) >gi|150842|gb|AAA50985.1| (L07290)
NAD-dependent glutamate dehydrogenase [Porphyromonas
gingivalis]
Length = 445
Score = 202 bits (508), Expect = 7e-51
Identities = 139/402 (34%), Positives = 200/402 (49%), Gaps = 18/402 (4%)
Query: 28 LEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQYNWARGPTKGGIRWHPEETLSTVKALA 87
+E + P R+ +P D G V+V G+RVQ+N A GP KGGIR+HP LS +K L
Sbjct: 47 IERIVEPDRVFTFRVPWVDDQGKVQVNIGYRVQFNNAIGPYKGGIRFHPSVNLSILKFLG 106
Query: 88 AWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREKERLARGYIRAIYDVISPYEDIPAPDVY 147
+K A+ LP GGGKGG PK S+ E R + ++ ++ I P DIPA D+
Sbjct: 107 FEQMFKNALTTLPMGGGKGGADFSPKGKSEAEIMRFCQSFMTELWRNIGPDTDIPAGDIG 166
Query: 148 TNPQIMAWMMDEYETIARRKTPAFGIITGKPLSIGGSLGRNEATARGASYTIREAAKVLG 207
+ + +M Y+ +AR T G +TGK GGS R E+T GA Y ++ K G
Sbjct: 167 VGGREVGYMFGMYKKLAREHT---GTLTGKGFEFGGSRLRPESTGFGAVYFVQNMCKQNG 223
Query: 208 WDDLKGKTIAIQGYGNAGYYLAKIMSEDYGMKVVAVSDSKGGIYNPDGLNADEVLKWK-- 265
D KGKT+AI G+GN + +A+ +E G+KVV + G +Y+PDG+N E +
Sbjct: 224 -VDYKGKTLAISGFGNVAWGVAQKATE-LGIKVVTIYGPDGYVYDPDGINTPEKFRCMLD 281
Query: 266 -REHGS------VKDFPGATNITNEELLELEVDVLAPAAIEEVITKKNADNIK---AKIV 315
R+ G+ VK FP A ++ E +VD P A + + ++A + +V
Sbjct: 282 LRDSGNDVVSDYVKRFPNAQFFPGKKPWEQKVDFAMPCATQNEMNLEDAKTLHKNGVTLV 341
Query: 316 AEVANGPVTPEADEILFEKGILQIPDFLCNAGGVTVSYFEWVQNITGYYWTLEEVREKLD 375
AE +N T EA E +L P NAGGV+ S E QN WT EEV + L
Sbjct: 342 AETSNMGCTAEASEYYVANKMLFAPGKAVNAGGVSCSGLEMTQNAMHLVWTNEEVDKWLH 401
Query: 376 KKMTKAFYDVYNTAKEKN-IHMRDAAYVVAVQRVYQAMLDRG 416
+ M K+ N I A + +V +AM+ +G
Sbjct: 402 QIMQDIHEQCVTYGKDGNYIDYVKGANIAGFMKVAKAMVAQG 443
>sp|P94316|DHE4_BACFR NADP-SPECIFIC GLUTAMATE DEHYDROGENASE (NADP-GDH) (NAD(P)H-DEPENDENT
GLUTAMATE DEHYDROGENASE) >gi|1685286|gb|AAC26399.1|
(U78108) NAD(H) glutamate dehydrogenase [Bacteroides
fragilis]
Length = 445
Score = 201 bits (507), Expect = 9e-51
Identities = 135/402 (33%), Positives = 200/402 (49%), Gaps = 18/402 (4%)
Query: 28 LEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQYNWARGPTKGGIRWHPEETLSTVKALA 87
+E L P RI + D G V+ G+RVQ+N A GP KGGIR+H LS +K L
Sbjct: 47 IERLVEPDRIFTFRVTWVDDKGEVQTNLGYRVQFNNAIGPYKGGIRFHASVNLSILKFLG 106
Query: 88 AWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREKERLARGYIRAIYDVISPYEDIPAPDVY 147
T+K A+ LP GGGKGG P+ SD E R + ++ ++ + P D+PA D+
Sbjct: 107 FEQTFKNALTTLPMGGGKGGSDFSPRGKSDAEIMRFCQAFMLELWRHLGPDMDVPAGDIG 166
Query: 148 TNPQIMAWMMDEYETIARRKTPAFGIITGKPLSIGGSLGRNEATARGASYTIREAAKVLG 207
+ + +M Y+ + R T G TGK L GGSL R EAT G Y + + + G
Sbjct: 167 VGGREVGYMFGMYKKLTREFT---GTFTGKGLEFGGSLIRPEATGFGGLYFVNQMLQTKG 223
Query: 208 WDDLKGKTIAIQGYGNAGYYLAKIMSEDYGMKVVAVSDSKGGIYNPDGLNADEV--LKWK 265
D+KGKT+AI G+GN + A +E G KVV +S G IY+P+G++ +++ +
Sbjct: 224 -IDIKGKTVAISGFGNVAWGAATKATE-LGAKVVTISGPDGYIYDPNGISGEKIDYMLEL 281
Query: 266 REHGS------VKDFPGATNITNEELLELEVDVLAPAAIEEVITKKNADNI---KAKIVA 316
R G+ +FPG+T + + E++ D+ P A + + ++A N+ V
Sbjct: 282 RASGNDIVAPYADEFPGSTFVAGKRPWEVKADIALPCATQNELNGEDAKNLIDNNVLCVG 341
Query: 317 EVANGPVTPEADEILFEKGILQIPDFLCNAGGVTVSYFEWVQNITGYYWTLEEVREKLDK 376
E++N TPEA ++ E + P NAGGV S E QN W+ EV EKL
Sbjct: 342 EISNMGCTPEAIDLFIEHKTMYAPGKAVNAGGVATSGLEMSQNAMHLSWSAAEVDEKLHS 401
Query: 377 KM--TKAFYDVYNTAKEKNIHMRDAAYVVAVQRVYQAMLDRG 416
M A Y T + I+ A + +V AM+ +G
Sbjct: 402 IMHGIHAQCVKYGTEPDGYINYVKGANIAGFMKVAHAMMGQG 443
>sp|P28724|DHE4_GIALA NADP-SPECIFIC GLUTAMATE DEHYDROGENASE (NADP-GDH)
>gi|283447|pir||A42489 glutamate dehydrogenase (NADP+)
(EC 1.4.1.4) - Giardia lamblia >gi|159109|gb|AAA29155.1|
(M84604) NADP-dependent glutamate dehydrogenase [Giardia
intestinalis]
Length = 449
Score = 198 bits (499), Expect = 8e-50
Identities = 142/423 (33%), Positives = 209/423 (48%), Gaps = 31/423 (7%)
Query: 15 ERAAQYMKISEEALEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQYNWARGPTKGGIRW 74
ER +Y+ I E LE P+R++ +P D G + V GFRVQYN A GP KGG+R+
Sbjct: 39 EREPKYIPIFERMLE----PERVIIFRVPWMDDAGRINVNRGFRVQYNSALGPYKGGLRF 94
Query: 75 HPEETLSTVKALAAWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREKERLARGYIRAIYDV 134
HP LS +K L K ++ LP GGGKGG DPK SD E R + ++ +
Sbjct: 95 HPSVNLSILKFLGFEQILKNSLTTLPMGGGKGGSDFDPKGKSDNEVMRFCQSFMTELQRH 154
Query: 135 ISPYEDIPAPDVYTNPQIMAWMMDEYETIARRKTPAFGIITGKPLSIGGSLGRNEATARG 194
+ D+PA D+ + + ++ +Y+ + T G++TGK + GGS R EAT G
Sbjct: 155 VGADTDVPAGDIGVGAREIGYLYGQYKRLRNEFT---GVLTGKNVKWGGSFIRPEATGYG 211
Query: 195 ASYTIREAAKVLGWDDLKGKTIAIQGYGNAGYYLAKIMSEDYGMKVVAVSDSKGGIYNPD 254
A Y + E K ++GK + + G GN + + + + G KV+ SDS G I + D
Sbjct: 212 AVYFLEEMCKDNN-TVIRGKNVLLSGSGNVAQFACEKLIQ-LGAKVLTFSDSNGTIVDKD 269
Query: 255 GLNADEV-----LKWKREHGSVKDF----PGATNITNE---ELLELEVDVLAPAAIEEVI 302
G N +++ LK + G V +F P + E E ++D + P A + +
Sbjct: 270 GFNEEKLAHLMYLK-NEKRGRVSEFKDKYPSVAYYEGKKPWECFEGQMDCIMPCATQNEV 328
Query: 303 TKKNADNIKA---KIVAEVANGPVTPEADEILFEKGILQIPDFLCNAGGVTVSYFEWVQN 359
+ +A + K VAE AN P T EA + KG++ P NAGGV+VS E QN
Sbjct: 329 SGDDATRLVGLGLKFVAEGANMPSTAEAVHVYHAKGVMYGPAKASNAGGVSVSGLEMSQN 388
Query: 360 ITGYYWTLEEVREKLDKKMTKAFYDVYNTAKE----KNIHMRDAAYVVAVQRVYQAMLDR 415
WT EEV +KL M F +TAK+ KN M A + +V +M+++
Sbjct: 389 SVRLQWTAEEVDQKLRGIMRGIFVACRDTAKKYGHPKNYQM--GANIAGFLKVADSMIEQ 446
Query: 416 GWV 418
G V
Sbjct: 447 GCV 449
>sp|P94598|DHE4_BACTN NADP-SPECIFIC GLUTAMATE DEHYDROGENASE (NADP-GDH) (NAD(P)H-DEPENDENT
GLUTAMATE DEHYDROGENASE)
Length = 444
Score = 195 bits (491), Expect = 7e-49
Identities = 139/405 (34%), Positives = 208/405 (51%), Gaps = 21/405 (5%)
Query: 28 LEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQYNWARGPTKGGIRWHPEETLSTVKALA 87
+E L P R+ + + D G+++ G+RVQ+N A GP KGGIR+H LS +K LA
Sbjct: 47 IERLCIPDRVFQFRVTWMDDKGNIQTNMGYRVQHNNAIGPYKGGIRFHASVNLSILKFLA 106
Query: 88 AWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREKERLARGYIRAIYDVISPYEDIPAPDVY 147
T+K ++ LP GGGKGG P+ S+ E R + ++ ++ I P D+PA D+
Sbjct: 107 FEQTFKNSLTTLPMGGGKGGSDFSPRGKSNAEVMRFVQAFMLELWRHIGPETDVPAGDIG 166
Query: 148 TNPQIMAWMMDEYETIARRKTPAFGIITGKPLSIGGSLGRNEATARGASYTIREAAKVLG 207
+ + +M Y+ +A T G TGK GGSL R EAT G Y + E K G
Sbjct: 167 VGGREVGFMFGMYKKLAHEFT---GTFTGKGREFGGSLIRPEATGYGNIYFLMEMLKTKG 223
Query: 208 WDDLKGKTIAIQGYGN-AGYYLAKIMSEDYGMKVVAVSDSKGGIYNPDGLN---ADEVLK 263
DLKGK + G GN A Y + K++ + G KVV SDS G IY+PDG++ D +++
Sbjct: 224 -TDLKGKVCLVSGSGNVAQYTIEKVI--ELGGKVVTCSDSDGYIYDPDGIDREKLDYIME 280
Query: 264 WKREH-GSVKDFP---GATNITNEELLELEVDVLAPAAIEEVITKKNADNIKAK---IVA 316
K + G ++++ G + + + D+ P+A + + +A + A V+
Sbjct: 281 LKNLYRGRIREYAEKYGCKYVEGAKPWGEKCDIALPSATQNELNGDHARQLVANGCIAVS 340
Query: 317 EVANGPVTPEADEILFEKGILQIPDFLCNAGGVTVSYFEWVQNITGYYWTLEEVREKLDK 376
E AN P TPEA + + IL P NAGGV+VS E QN W+ EEV EKL K
Sbjct: 341 EGANMPSTPEAVRVFQDAKILYAPGKAANAGGVSVSGLEMTQNSIKLSWSAEEVDEKL-K 399
Query: 377 KMTKAFYDV---YNTAKEKNIHMRDAAYVVAVQRVYQAMLDRGWV 418
+ K ++ Y T + ++ A V +V +AM+ +G V
Sbjct: 400 SIMKNIHEACVQYGTEADGYVNYVKGANVAGFMKVAKAMMAQGIV 444
>sp|P43793|DHE4_HAEIN NADP-SPECIFIC GLUTAMATE DEHYDROGENASE (NADP-GDH)
>gi|1074137|pir||A64053 glutamate dehydrogenase (NADP+)
(EC 1.4.1.4) - Haemophilus influenzae (strain Rd KW20)
>gi|1573147|gb|AAC21858.1| (U32704) glutamate
dehydrogenase (gdhA) [Haemophilus influenzae Rd]
Length = 449
Score = 192 bits (484), Expect = 5e-48
Identities = 138/411 (33%), Positives = 198/411 (47%), Gaps = 28/411 (6%)
Query: 24 SEEALEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQYNWARGPTKGGIRWHPEETLSTV 83
SE LE L P+R + + D G V+V FRVQ+N A GP KGG+R+HP LS +
Sbjct: 47 SEALLERLVEPERAFQFRVAWTDDKGQVQVNRAFRVQFNSAIGPFKGGMRFHPSVNLSIL 106
Query: 84 KALAAWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREKERLARGYIRAIYDVISPYEDIPA 143
K L +K A+ LP GG KGG DPK SD E R + + +Y + D+PA
Sbjct: 107 KFLGFEQIFKNALTTLPMGGAKGGSDFDPKGKSDAEVMRFCQALMAELYRHVGADTDVPA 166
Query: 144 PDVYTNPQIMAWMMDEYETIARRKTPAFGIITGKPLSIGGSLGRNEATARGASYTIREAA 203
D+ + + ++ + ++ + F TG+ LS GGSL R EAT G Y +
Sbjct: 167 GDIGVGGREVGYLAGYMKKLSNQSACVF---TGRGLSFGGSLIRPEATGYGLIYFAQAML 223
Query: 204 KVLGWDDLKGKTIAIQGYGN-AGYYLAKIMSEDYGMKVVAVSDSKGGIYNPDGLNADEVL 262
G D GK +++ G GN A Y + K +S G KVV SDS G +Y+P+G +++
Sbjct: 224 AEKG-DSFAGKVVSVSGSGNVAQYAIEKALS--LGAKVVTCSDSSGYVYDPNGFTTEKLA 280
Query: 263 KW----KREHGSVKDFP---GATNITNEELLELEVDVLAPAAIEEVITKKNADNI---KA 312
+ G VKD+ G + E++VD+ P A + + +A +
Sbjct: 281 ALFDIKNTKRGRVKDYAEQFGLQYFEGKRPWEVQVDIALPCATQNELELSDAQRLIKNGV 340
Query: 313 KIVAEVANGPVTPEADEILFEKGILQIPDFLCNAGGVTVSYFEWVQNITGYYWTLEEVRE 372
K+VAE AN P T EA E L +L P NAGGV S E Q+ YWT EEV
Sbjct: 341 KLVAEGANMPTTIEATEALLAADVLFGPGKAANAGGVATSGLEMAQSSQRLYWTAEEV-- 398
Query: 373 KLDKKMTKAFYDVYNTAK-------EKNIHMRDAAYVVAVQRVYQAMLDRG 416
D ++ + D++ K ++NI+ A V +V AML +G
Sbjct: 399 --DAQLHRIMLDIHANCKKYGTIEGQENINYVVGANVAGFVKVADAMLAQG 447
>gb|AAB40143.1| (U82241) NAD(P)H-dependent glutamate dehydrogenase [Bacteroides
thetaiotaomicron]
Length = 381
Score = 191 bits (481), Expect = 1e-47
Identities = 135/386 (34%), Positives = 200/386 (50%), Gaps = 21/386 (5%)
Query: 47 DDGSVKVFTGFRVQYNWARGPTKGGIRWHPEETLSTVKALAAWMTWKTAVMDLPYGGGKG 106
D G+++ G+RVQ+N A GP KGGIR+H LS +K LA T+K ++ LP GGGKG
Sbjct: 3 DKGNIQTNMGYRVQHNNAIGPYKGGIRFHASVNLSILKFLAFEQTFKNSLTTLPMGGGKG 62
Query: 107 GIIVDPKKLSDREKERLARGYIRAIYDVISPYEDIPAPDVYTNPQIMAWMMDEYETIARR 166
G P+ S+ E R + ++ ++ I P D+PA D+ + + +M Y+ +A
Sbjct: 63 GSDFSPRGKSNAEVMRFVQAFMLELWRHIGPETDVPAGDIGVGGREVGFMFGMYKKLAHE 122
Query: 167 KTPAFGIITGKPLSIGGSLGRNEATARGASYTIREAAKVLGWDDLKGKTIAIQGYGN-AG 225
T G TGK GGSL R EAT G Y + E K G DLKGK + G GN A
Sbjct: 123 FT---GTFTGKGREFGGSLIRPEATGYGNIYFLMEMLKTKG-TDLKGKVCLVSGSGNVAQ 178
Query: 226 YYLAKIMSEDYGMKVVAVSDSKGGIYNPDGLN---ADEVLKWKREH-GSVKDFP---GAT 278
Y + K++ + G KVV SDS G IY+PDG++ D +++ K + G ++++ G
Sbjct: 179 YTIEKVI--ELGGKVVTCSDSDGYIYDPDGIDREKLDYIMELKNLYRGRIREYAEKYGCK 236
Query: 279 NITNEELLELEVDVLAPAAIEEVITKKNADNIKAK---IVAEVANGPVTPEADEILFEKG 335
+ + + D+ P+A + + +A + A V+E AN P TPEA + +
Sbjct: 237 YVEGAKPWGEKCDIALPSATQNELNGDHARQLVANGCIAVSEGANMPSTPEAVRVFQDAK 296
Query: 336 ILQIPDFLCNAGGVTVSYFEWVQNITGYYWTLEEVREKLDKKMTKAFYDV---YNTAKEK 392
IL P NAGGV+VS E QN W+ EEV EKL K + K ++ Y T +
Sbjct: 297 ILYAPGKAANAGGVSVSGLEMTQNSIKLSWSAEEVDEKL-KSIMKNIHEACVQYGTEADG 355
Query: 393 NIHMRDAAYVVAVQRVYQAMLDRGWV 418
++ A V +V +AM+ +G V
Sbjct: 356 YVNYVKGANVAGFMKVAKAMMAQGIV 381
>emb|CAB54142.1| (AJ010746) glutamate dehydrogenase [Antarctic bacterium TAD1]
Length = 448
Score = 191 bits (480), Expect = 1e-47
Identities = 139/427 (32%), Positives = 215/427 (49%), Gaps = 29/427 (6%)
Query: 9 IAVKQLERA-AQYMKISEEALEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQYNWARGP 67
I +K L A +Y K+ + E L P R+ + E D+G +++ G+RVQ++ A GP
Sbjct: 29 ITIKPLYDAHPEYDKL--KVFERLVEPDRVFGFRVNWEDDNGEIQINRGWRVQFSNALGP 86
Query: 68 TKGGIRWHPEETLSTVKALAAWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREKERLARGY 127
KGG+R+HP S +K L +K A+ LP GGGKGG DPK +D E R +
Sbjct: 87 YKGGLRFHPTVNQSVLKFLGFEQIFKNALTGLPIGGGKGGSDFDPKGKTDSEIRRFCYAF 146
Query: 128 IRAIYDVISPYEDIPAPDVYTNPQIMAWMMDEYETIARRKTPAFGIITGKPLSIGGSLGR 187
+R ++ ++ D+PA D+ + +++M Y+ + R T G+ITGK + GGSL R
Sbjct: 147 MRELHHYVNKDMDVPAGDIGVGGREVSYMFAMYKNLTREST---GVITGKGVGFGGSLMR 203
Query: 188 NEATARGASYTIREAAKVLGWDDLKGKTIAIQGYGNAGYYLAKIMSEDYGMKVVAVSDSK 247
EAT GA Y ++ + ++GK + + G GN + A+ + G V+ VSDSK
Sbjct: 204 TEATGYGAVYFLQNMLAAQN-ESIEGKKVLVSGAGNVSLHAAE-KATLIGAIVLTVSDSK 261
Query: 248 GGIYNPDGLNADEVLKW----KREHGSVKDFP---GATNITNEELLELEVDVLAPAAIEE 300
G IY+ GLN E + W K +H + D+ G + +++ ++ D+ P+A +
Sbjct: 262 GTIYDAKGLN-QEKIDWLKVQKDQHKPLADYVEVFGGEWMADQKPWSIKADIAIPSATQN 320
Query: 301 VITKKNA----DNIKAKIVAEVANGPVTPEADEILFEKGILQIPDFLCNAGGVTVSYFEW 356
I +++A DN K + E AN P+T EA + + + P NAGGV VS E
Sbjct: 321 EINEEDAKLLVDN-GVKYIVEGANMPLTAEAIDYIRLHRVHYAPGKAANAGGVAVSALEM 379
Query: 357 VQNITGYYWTLEEVREKLDKKMTKAFYD-------VYNTAKEKNIHMRDAAYVVAVQRVY 409
QN Y T E+V E+L M K +D +Y E I A +V +RV
Sbjct: 380 SQNSVRQYQTFEQVDERLQGIM-KDIHDSSAQASEMYGQTDEGYIDYMSGANMVGFKRVA 438
Query: 410 QAMLDRG 416
A++ G
Sbjct: 439 DALVAFG 445
>gb|AAG01158.1| (AF285427) NADP-specific glutamate dehydrogenase [Neurospora
intermedia]
Length = 454
Score = 191 bits (480), Expect = 1e-47
Identities = 154/453 (33%), Positives = 219/453 (47%), Gaps = 47/453 (10%)
Query: 7 FEIAVKQL----ERAAQYMKISE--EALEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQ 60
FE A K+L E ++ + K E AL P+R+++ + E D+G+V+V G+RVQ
Sbjct: 10 FEQAYKELAYTLENSSLFQKHPEYRTALTVASIPERVIQFRVVWEDDNGNVQVNRGYRVQ 69
Query: 61 YNWARGPTKGGIRWHPEETLSTVKALAAWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREK 120
+N A GP KGG+R HP LS +K L +K A+ L GGGKGG DPK SD E
Sbjct: 70 FNSALGPYKGGLRLHPSVNLSILKFLGFEQIFKNALTGLSMGGGKGGADFDPKGKSDAEI 129
Query: 121 ERLARGYIRAIYDVISPYEDIPAPDVYTNPQIMAWMMDEYETIARRKTPAFGIITGKPLS 180
R ++ ++ I D+PA D+ + + +M Y A R G++TGK LS
Sbjct: 130 RRFCCAFMAELHKHIGADTDVPAGDIGVGGREIGYMFGAYRKAANRFE---GVLTGKGLS 186
Query: 181 IGGSLGRNEATARGASYTIREAAKVLGWDDLKGKTIAIQGYGNAGYYLAKIMSEDYGMKV 240
GGSL R EAT G Y + + G GK +A+ G GN Y A + E G V
Sbjct: 187 WGGSLIRPEATGYGLVYYVGHMLEYSGAGSYAGKRVALSGSGNVAQYAALKLIE-LGATV 245
Query: 241 VAVSDSKGGIY--NPDGLNADE---VLKWKREHGSVKDFPGATNITNEE-----LLELEV 290
V++SDSKG + G+ ++ V+ K S+ F A ++ E L +V
Sbjct: 246 VSLSDSKGALVATGESGITVEDINAVMAIKEARQSLTSFQHAGHLKWIEGARPWLHVGKV 305
Query: 291 DVLAPAAIEEVITKKNADNIKA---KIVAEVANGPVTPEADEILFE--------KGILQI 339
D+ P A + ++K+ A+ + A K VAE +N T EA E+ FE + +
Sbjct: 306 DIALPCATQNEVSKEEAEGLLAAGCKFVAEGSNMGCTLEAIEV-FENHRKEKKGEAVWYA 364
Query: 340 PDFLCNAGGVTVSYFEWVQNITGYYWTLEEVREKLDKKMTKAFYDVYNTAKEKNIHMRDA 399
P N GGV VS E QN WT EV EKL M AF++ NTAK I++ A
Sbjct: 365 PGKAANCGGVAVSGLEMAQNSQRLNWTQAEVDEKLKDIMKNAFFNGLNTAK---IYVEAA 421
Query: 400 ----------AYVVAVQRVYQAMLDRG--WVKH 420
+ + +V QAM D+G W K+
Sbjct: 422 EGELPSLVAGSNIAGFVKVAQAMHDQGDWWSKN 454
>dbj|BAB04543.1| (AP001509) glutamate dehydrogenase [Bacillus halodurans]
Length = 464
Score = 191 bits (480), Expect = 1e-47
Identities = 133/433 (30%), Positives = 213/433 (48%), Gaps = 43/433 (9%)
Query: 22 KISEEALEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQYNWARGPTKGGIRWHPEETLS 81
+I A E L +I++ I V + G +++ +RVQ+N G KGGIR+ +
Sbjct: 34 RIVLSAQEILTTTDKIIKSYIRVSTEHGIMRI-PAYRVQHNNISGFYKGGIRFSEFVSEE 92
Query: 82 TVKALAAWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREKERLARGYIRAIYDVISPYEDI 141
V+ LA MT K A+ LP+GG KGG+ VDP+K S++E +++ Y++ + P DI
Sbjct: 93 EVENLAILMTLKNALHRLPFGGAKGGVHVDPRKYSEKELNLISKKYVQRFARDLGPNHDI 152
Query: 142 PAPDVYTNPQIMAWMMDEYETIARRKTPAFGIITGKPLSIGGSLGRNEATARGA--SY-- 197
PAPD+ TN Q++ WM+ E++TI + G TGK + GG+ GR EAT +G SY
Sbjct: 153 PAPDLGTNEQVIDWMVGEFKTIHPGQA-YLGSFTGKSVENGGARGRREATGKGTFLSYIW 211
Query: 198 ----------TIREAAKVLGWDDLKGK----------TIAIQGYGNAGYY--LAKIMSED 235
+ + W+ + +A+QG+GN G L +
Sbjct: 212 LLSQWYDEHVSGNGINRTKQWETISNLKQQADNSDPIRVAVQGFGNVGSVAALEAYQCSE 271
Query: 236 YGMKVVAVSDSKGGIYNPDGLNADEVLKWKREHGSVKDFP-----------GATNITNEE 284
+VVAVSD +YN GL+ + + KD P A+ + +
Sbjct: 272 IAHRVVAVSDRYTTLYNEKGLDVRALAAYTI---GGKDLPKNSEELAAAGVEASVLPVDA 328
Query: 285 LLELEVDVLAPAAIEEVITKKNADNIKAKIVAEVANGPVTPEADEILFEKGILQIPDFLC 344
+L E DVL AAIE I ++N + A+++ E AN P++ EAD+ G + IPD L
Sbjct: 329 VLTCETDVLILAAIENQIHERNMKQVNARVLVEGANAPISTEADDYFEAAGTVVIPDILA 388
Query: 345 NAGGVTVSYFEWVQNITGYYWTLEEVREKLDKKMTKAFYDVYNTAKEKNIH-MRDAAYVV 403
NAGGV VSY EW Q+ ++ +++ +++ +M + VY H +R + +
Sbjct: 389 NAGGVIVSYLEWKQSRITELYSEDDILDEMGTQMKETLKSVYERYFSSVGHTLRFTCFTL 448
Query: 404 AVQRVYQAMLDRG 416
A++R+ + G
Sbjct: 449 ALERLTSLLYKHG 461
>gb|AAC06213.1| (AF051892) putative glutamate dehydrogenase [Trypanosoma cruzi]
Length = 447
Score = 190 bits (479), Expect = 2e-47
Identities = 139/436 (31%), Positives = 216/436 (48%), Gaps = 30/436 (6%)
Query: 4 QDPFEIAVKQ--------LERAAQYMKISEEALEFLKRPQRIVEVTIPVEMDDGSVKVFT 55
Q FE AV + LE+ +Y + + LE L P+R+V+ + D G V+V
Sbjct: 21 QPEFEQAVHEVMTSLWPFLEKHPEYCQ--DSLLERLVEPERVVQFRVSWVDDKGEVQVNR 78
Query: 56 GFRVQYNWARGPTKGGIRWHPEETLSTVKALAAWMTWKTAVMDLPYGGGKGGIIVDPKKL 115
+RVQ+N + GP KGG+R+HP LS +K L T+K ++ LP GGGKGG DPK
Sbjct: 79 AWRVQFNSSIGPYKGGMRFHPSVNLSILKFLGFEQTFKNSLTTLPMGGGKGGSDFDPKGK 138
Query: 116 SDREKERLARGYIRAIYDVISPYEDIPAPDVYTNPQIMAWMMDEYETIARRKTPAFGIIT 175
SDRE R + + +Y I P D+PA D+ + + +M + + K F T
Sbjct: 139 SDREVMRFCQALVTELYRHIGPDTDVPAGDIGVGGREVGYMAGMTQKLTNNKACRF---T 195
Query: 176 GKPLSIGGSLGRNEATARGASYTIREAAKVLGWDDLKGKTIAIQGYGNAGYYLAKIMSED 235
GK +S GS R EAT G Y + K +LKGKT+ + G GN Y + +
Sbjct: 196 GKGISFQGSQMRPEATGYGVVYFLDALLKKHN-QELKGKTVVVSGSGNVAQYAVEKCLQ- 253
Query: 236 YGMKVVAVSDSKGGIYNPDGLNADE---VLKWKR-EHGSVKDFP---GATNITNEELLEL 288
G KV++VSDS+G +++ +G ++ ++ K +HG+V+++ G + +
Sbjct: 254 LGAKVLSVSDSRGCVHDAEGFTPEKLKVLMDIKNVKHGTVEEYAKGLGLQYYAGKRPWHI 313
Query: 289 EVDVLAPAAIEEVITKKNADNI---KAKIVAEVANGPVTPEADEILFEKGILQIPDFLCN 345
+ D+ P A + + ++A + +VAE AN P T +A G+L P N
Sbjct: 314 KADIALPCATQNELELEDAKALIKNGVTVVAEGANMPTTTDATMEFINAGVLFAPGKAAN 373
Query: 346 AGGVTVSYFEWVQNITGYYWTLEEVREKLDKKMTKAFYDV---YNTAKEKNIHMRDAAYV 402
AGGV +S E QN WT EEV +KL +++ + +D Y T K ++ + A +
Sbjct: 374 AGGVAISGLEMSQNAARLSWTAEEVEQKL-REIMNSIHDACVKYGTVGGKTNYV-NGANI 431
Query: 403 VAVQRVYQAMLDRGWV 418
+V +AM G V
Sbjct: 432 AGFVKVAEAMKGLGVV 447
>sp|P00369|DHE4_NEUCR NADP-SPECIFIC GLUTAMATE DEHYDROGENASE (NADP-GDH)
>gi|66084|pir||DENCEN glutamate dehydrogenase (NADP+)
(EC 1.4.1.4) - Neurospora crassa
>gi|168753|gb|AAA33558.1| (K01409) NADP-specific
glutamate dehydrogenase [Neurospora crassa]
Length = 454
Score = 190 bits (478), Expect = 2e-47
Identities = 152/450 (33%), Positives = 217/450 (47%), Gaps = 41/450 (9%)
Query: 7 FEIAVKQL----ERAAQYMKISE--EALEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQ 60
FE A K+L E ++ + K E AL P+R+++ + E D+G+V+V G+RVQ
Sbjct: 10 FEQAYKELAYTLENSSLFQKHPEYRTALTVASIPERVIQFRVVWEDDNGNVQVNRGYRVQ 69
Query: 61 YNWARGPTKGGIRWHPEETLSTVKALAAWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREK 120
+N A GP KGG+R HP LS +K L +K A+ L GGGKGG DPK SD E
Sbjct: 70 FNSALGPYKGGLRLHPSVNLSILKFLGFEQIFKNALTGLSMGGGKGGADFDPKGKSDAEI 129
Query: 121 ERLARGYIRAIYDVISPYEDIPAPDVYTNPQIMAWMMDEYETIARRKTPAFGIITGKPLS 180
R ++ ++ I D+PA D+ + + +M Y A R G++TGK LS
Sbjct: 130 RRFCCAFMAELHKHIGADTDVPAGDIGVGGREIGYMFGAYRKAANRFE---GVLTGKGLS 186
Query: 181 IGGSLGRNEATARGASYTIREAAKVLGWDDLKGKTIAIQGYGNAGYYLAKIMSEDYGMKV 240
GGSL R EAT G Y + + G GK +A+ G GN Y A + E G V
Sbjct: 187 WGGSLIRPEATGYGLVYYVGHMLEYSGAGSYAGKRVALSGSGNVAQYAALKLIE-LGATV 245
Query: 241 VAVSDSKGGIY--NPDGLNADE---VLKWKREHGSVKDFPGATNITNEE-----LLELEV 290
V++SDSKG + G+ ++ V+ K S+ F A ++ E L +V
Sbjct: 246 VSLSDSKGALVATGESGITVEDINAVMAIKEARQSLTSFQHAGHLKWIEGARPWLHVGKV 305
Query: 291 DVLAPAAIEEVITKKNADNIKA---KIVAEVANGPVTPEADEILFE--------KGILQI 339
D+ P A + ++K+ A+ + A K VAE +N T EA E+ FE + +
Sbjct: 306 DIALPCATQNEVSKEEAEGLLAAGCKFVAEGSNMGCTLEAIEV-FENNRKEKKGEAVWYA 364
Query: 340 PDFLCNAGGVTVSYFEWVQNITGYYWTLEEVREKLDKKMTKAFYDVYNTAKE-------K 392
P N GGV VS E QN WT EV EKL M AF++ NTAK +
Sbjct: 365 PGKAANCGGVAVSGLEMAQNSQRLNWTQAEVDEKLKDIMKNAFFNGLNTAKTYVEAAEGE 424
Query: 393 NIHMRDAAYVVAVQRVYQAMLDRG--WVKH 420
+ + + +V QAM D+G W K+
Sbjct: 425 LPSLVAGSNIAGFVKVAQAMHDQGDWWSKN 454
>prf||1003201A dehydrogenase,NADP specific Glu [Neurospora crassa]
Length = 454
Score = 190 bits (478), Expect = 2e-47
Identities = 152/450 (33%), Positives = 217/450 (47%), Gaps = 41/450 (9%)
Query: 7 FEIAVKQL----ERAAQYMKISE--EALEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQ 60
FE A K+L E ++ + K E AL P+R+++ + E D+G+V+V G+RVQ
Sbjct: 10 FEQAYKELAYTLENSSLFQKHPEYRTALTVASIPERVIQFRVVWEDDNGNVQVNRGYRVQ 69
Query: 61 YNWARGPTKGGIRWHPEETLSTVKALAAWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREK 120
+N A GP KGG+R HP LS +K L +K A+ L GGGKGG DPK SD E
Sbjct: 70 FNSALGPYKGGLRLHPSVNLSILKFLGFEQIFKNALYGLSMGGGKGGADFDPKGKSDAEI 129
Query: 121 ERLARGYIRAIYDVISPYEDIPAPDVYTNPQIMAWMMDEYETIARRKTPAFGIITGKPLS 180
R ++ ++ I D+PA D+ + + +M Y A R G++TGK LS
Sbjct: 130 RRFCCAFMAELHKHIGADTDVPAGDIGVGGREIGYMFGAYRKAANRFE---GVLTGKGLS 186
Query: 181 IGGSLGRNEATARGASYTIREAAKVLGWDDLKGKTIAIQGYGNAGYYLAKIMSEDYGMKV 240
GGSL R EAT G Y + + G GK +A+ G GN Y A + E G V
Sbjct: 187 WGGSLIRPEATGYGLVYYVGHMLEYSGAGSYAGKRVALSGSGNVAQYAALKLIE-LGATV 245
Query: 241 VAVSDSKGGIY--NPDGLNADE---VLKWKREHGSVKDFPGATNITNEE-----LLELEV 290
V++SDSKG + G+ ++ V+ K S+ F A ++ E L +V
Sbjct: 246 VSLSDSKGALVATGESGITVEDINAVMAIKEARQSLTSFQHAGHLKWIEGARPWLHVGKV 305
Query: 291 DVLAPAAIEEVITKKNADNIKA---KIVAEVANGPVTPEADEILFE--------KGILQI 339
D+ P A + ++K+ A+ + A K VAE +N T EA E+ FE + +
Sbjct: 306 DIALPCATQNEVSKEEAEGLLAAGCKFVAEGSNMGCTLEAIEV-FENNRKEKKGEAVWYA 364
Query: 340 PDFLCNAGGVTVSYFEWVQNITGYYWTLEEVREKLDKKMTKAFYDVYNTAKE-------K 392
P N GGV VS E QN WT EV EKL M AF++ NTAK +
Sbjct: 365 PGKAANCGGVAVSGLEMAQNSQRLNWTQAEVDEKLKDIMKNAFFNGLNTAKTYVEAAEGE 424
Query: 393 NIHMRDAAYVVAVQRVYQAMLDRG--WVKH 420
+ + + +V QAM D+G W K+
Sbjct: 425 LPSLVAGSNIAGFVKVAQAMHDQGDWWSKN 454
>pir||S19250 glutamate dehydrogenase (NADP+) (EC 1.4.1.4) - Corynebacterium
glutamicum (ATCC 13032)
Length = 448
Score = 190 bits (478), Expect = 2e-47
Identities = 120/340 (35%), Positives = 177/340 (51%), Gaps = 12/340 (3%)
Query: 28 LEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQYNWARGPTKGGIRWHPEETLSTVKALA 87
++ L P+R V +P D G V V GFRVQ+N A GP KGG+R+HP L VK L
Sbjct: 51 IQRLCEPERPVIFRVPWVDDQGQVHVNRGFRVQFNSALGPYKGGLRFHPSVNLGIVKFLG 110
Query: 88 AWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREKERLARGYIRAIYDVISPYEDIPAPDVY 147
+K ++ LP GGGKGG DPK SD E R + ++ ++ I Y D+PA D+
Sbjct: 111 FGEIFKNSLTGLPIGGGKGGSDFDPKGKSDLEIMRFCKSFMTELHRHIGEYRDVPAGDIG 170
Query: 148 TNPQIMAWMMDEYETIARRKTPAFGIITGKPLSIGGSLGRNEATARGASYTIREAAKVLG 207
+ + ++ Y +A + G++TGK L+ GGSL R EAT G Y + E K G
Sbjct: 171 VGGREIGYLFGHYRRMANQHES--GVLTGKGLTWGGSLVRTEATGYGCVYFVSEMIKAKG 228
Query: 208 WDDLKGKTIAIQGYGNAGYYLAKIMSEDYGMKVVAVSDSKGGIYNPDGLNA---DEVLKW 264
+ + G+ I + G GN Y + +++ G V+ SDS G ++ P+G++ E+ +
Sbjct: 229 -ESISGQKIIVSGSGNVATYAIE-KAQELGATVIGFSDSSGWVHTPNGVDVAKLREIKEV 286
Query: 265 KREHGSV--KDFPGATNITNEELLELEVDVLAPAAIEEVITKKNADNIK---AKIVAEVA 319
+R SV + GAT T+ + +L+ D+ P A + + +NA + + VAE A
Sbjct: 287 RRARVSVYADEVEGATYHTDGSIWDLKCDIALPCATQNELNGENAKTLADNGCRFVAEGA 346
Query: 320 NGPVTPEADEILFEKGILQIPDFLCNAGGVTVSYFEWVQN 359
N P TPEA E+ E+ I P N GGV S E QN
Sbjct: 347 NMPSTPEAVEVFRERDIRFGPGKAANVGGVATSALEMQQN 386
>gb|AAG01159.1| (AF285428) NADP-specific glutamate dehydrogenase [Neurospora
sitophila]
Length = 454
Score = 189 bits (476), Expect = 4e-47
Identities = 143/411 (34%), Positives = 202/411 (48%), Gaps = 32/411 (7%)
Query: 7 FEIAVKQL----ERAAQYMKISE--EALEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQ 60
FE A K+L E ++ + K E AL P+R+++ + E D+G+V+V G+RVQ
Sbjct: 10 FEQAYKELAYTLENSSLFQKHPEYRTALAVASIPERVIQFRVVWEDDNGNVQVNRGYRVQ 69
Query: 61 YNWARGPTKGGIRWHPEETLSTVKALAAWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREK 120
+N A GP KGG+R HP LS +K L +K A+ L GGGKGG DPK SD E
Sbjct: 70 FNSALGPYKGGLRLHPSVNLSILKFLGFEQIFKNALTGLSMGGGKGGADFDPKGKSDAEI 129
Query: 121 ERLARGYIRAIYDVISPYEDIPAPDVYTNPQIMAWMMDEYETIARRKTPAFGIITGKPLS 180
R ++ ++ I D+PA D+ + + +M Y A R G++TGK LS
Sbjct: 130 RRFCCAFMAELHKHIGADTDVPAGDIGVGGREIGYMFGAYRKAANRFE---GVLTGKGLS 186
Query: 181 IGGSLGRNEATARGASYTIREAAKVLGWDDLKGKTIAIQGYGNAGYYLAKIMSEDYGMKV 240
GGSL R EAT G Y + + G GK +A+ G GN Y A + E G V
Sbjct: 187 WGGSLIRPEATGYGLVYYVGHMLEYSGAGSYAGKRVALSGSGNVAQYAALKLIE-LGATV 245
Query: 241 VAVSDSKGGIY--NPDGLNADE---VLKWKREHGSVKDFPGATNITNEE-----LLELEV 290
V++SDSKG + G+ ++ ++ K S+ F A ++ E L +V
Sbjct: 246 VSLSDSKGALVATGESGITVEDINAIMAIKEARQSLTTFQHAGHVKWIEGARPWLHVGKV 305
Query: 291 DVLAPAAIEEVITKKNADNIKA---KIVAEVANGPVTPEADEILFE--------KGILQI 339
D+ P A + ++K+ A+ + A K VAE +N T EA E+ FE + +
Sbjct: 306 DIALPCATQNEVSKEEAEGLLAAGCKFVAEGSNMGCTLEAIEV-FENNRKEKKGEAVWYA 364
Query: 340 PDFLCNAGGVTVSYFEWVQNITGYYWTLEEVREKLDKKMTKAFYDVYNTAK 390
P N GGV VS E QN WT EV EKL M AF++ NTAK
Sbjct: 365 PGKAANCGGVAVSGLEMAQNSQRLNWTQAEVDEKLKDIMKNAFFNGLNTAK 415
>gb|AAC95390.1| (AF109684) NADP-dependent glutamate dehydrogenase [Botryotinia
fuckeliana]
Length = 450
Score = 189 bits (475), Expect = 5e-47
Identities = 140/414 (33%), Positives = 202/414 (47%), Gaps = 36/414 (8%)
Query: 14 LERAAQYMKISE--EALEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQYNWARGPTKGG 71
LE + + K E AL+ + P+R+++ + E D V+V G+RVQ+N A GP KGG
Sbjct: 21 LENSTLFEKNPEYRTALKVVSIPERVIQFRVVWEDDKNQVQVNRGYRVQFNSALGPYKGG 80
Query: 72 IRWHPEETLSTVKALAAWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREKERLARGYIRAI 131
+R+HP LS +K L +K A+ L GGGKGG DPK SD E R ++R +
Sbjct: 81 LRFHPTVNLSVLKFLGFEQIFKNALTGLNIGGGKGGADFDPKGKSDNEIRRFCVSFMREL 140
Query: 132 YDVISPYEDIPAPDVYTNPQIMAWMMDEYETIARRKTPAFGIITGKPLSIGGSLGRNEAT 191
I D+PA D+ + + ++ Y+ I + G++TGK S GGSL R EAT
Sbjct: 141 SKHIGADTDVPAGDINVGGREIGFLFGAYKAIQNKWE---GVLTGKGGSWGGSLIRPEAT 197
Query: 192 ARGASYTIREAAKVLGWDDLKGKTIAIQGYGNAGYYLAKIMSEDYGMKVVAVSDSKGGI- 250
G Y + + G +GK +AI G GN Y A + + G VV++SDS+G +
Sbjct: 198 GYGLVYYVAHMIQYAGQGSFQGKRVAISGSGNVAQY-AALKCIELGATVVSLSDSQGSLI 256
Query: 251 ------YNPDGLNADEVLKWKR------EH-GSVKDFPGATNITNEELLELEVDVLAPAA 297
+ P+ + LK KR EH G K G+ T+ ++VDV P A
Sbjct: 257 AEGDAYFTPEDVGKIAELKLKRQSLTAFEHGGKYKYIEGSRPWTH-----VKVDVALPCA 311
Query: 298 IEEVITKKNADNI---KAKIVAEVANGPVTPEADEIL-------FEKGILQIPDFLCNAG 347
+ ++K+ A+++ A+ +AE +N T EA ++ +K I P NAG
Sbjct: 312 TQNEVSKEEAESLVASGARYIAEGSNMGCTQEAIDVFEAERKEKKDKAIWYAPGKAANAG 371
Query: 348 GVTVSYFEWVQNITGYYWTLEEVREKLDKKMTKAFYDVYNTAKEKNIHMRDAAY 401
GV VS E QN WT EEV EKL M AF T K K + +D Y
Sbjct: 372 GVAVSGLEMAQNSARISWTQEEVDEKLKDIMKNAFETGLETPK-KYVEAKDGEY 424
>pir||H83072 glutamate dehydrogenase PA4588 [imported] - Pseudomonas aeruginosa
(strain PAO1) >gi|9950836|gb|AAG07976.1|AE004872_7
(AE004872) glutamate dehydrogenase [Pseudomonas
aeruginosa]
Length = 445
Score = 185 bits (464), Expect = 1e-45
Identities = 141/437 (32%), Positives = 215/437 (48%), Gaps = 30/437 (6%)
Query: 3 EQDPFEIAVKQLERA------AQYMKISEEALEFLKRPQRIVEVTIPVEMDDGSVKVFTG 56
+Q F AV+++ R+ A + +E + P+R + +P D G V+V G
Sbjct: 18 DQPEFHQAVEEVLRSLWPFLEANPHYLEAGIIERIVEPERAILFRVPWVDDQGRVRVNRG 77
Query: 57 FRVQYNWARGPTKGGIRWHPEETLSTVKALAAWMTWKTAVMDLPYGGGKGGIIVDPKKLS 116
+RVQ + A GP KGG+R+HP L +K LA +K ++ LP GGGKGG DPK S
Sbjct: 78 YRVQMSSAIGPYKGGLRFHPSVNLGVLKFLAFEQVFKNSLTTLPMGGGKGGSDFDPKGKS 137
Query: 117 DREKERLARGYIRAIYDVISPYEDIPAPDVYTNPQIMAWMMDEYETIARRKTPAFGIITG 176
D E R + ++ +Y + D+PA D+ + + ++ +Y+ ++ + T ++TG
Sbjct: 138 DAEVMRFCQSFMSELYRHVGADLDVPAGDIGVGAREIGYLFGQYKRLSNQFT---SVLTG 194
Query: 177 KPLSIGGSLGRNEATARGASYTIREAAKVLGWDDLKGKTIAIQGYGNAGYYLAKIMSEDY 236
K LS GGSL R EAT G Y +E K G G+ +AI G GN Y A+ + E
Sbjct: 195 KGLSYGGSLIRPEATGFGCVYFAQEMLKDRG-RGFDGQRVAISGSGNVAQYAARKVME-M 252
Query: 237 GMKVVAVSDSKGGIYNPDGLNADEVLKWKRE-----HGSVKDFPGATNITNEELLE---- 287
G KV+++SDS+G +Y GL +DE ++ E G +++ ++ + LE
Sbjct: 253 GGKVISLSDSEGTLYAEAGL-SDEQWEYLMELKNVRRGRIREMAEQFSL---QFLEGRRP 308
Query: 288 --LEVDVLAPAAIEEVITKKNADNIKAK---IVAEVANGPVTPEADEILFEKGILQIPDF 342
L D+ P A + + ++A + A VAE AN P T EA ++ E GIL P
Sbjct: 309 WGLACDIALPCATQNELDAEDARRLLANGCVCVAEGANMPSTLEAVDLFLEAGILYAPGK 368
Query: 343 LCNAGGVTVSYFEWVQNITGYYWTLEEVREKLDKKMTKAFYDVYNTAKEK-NIHMRDAAY 401
NAGGV VS E QN W+ EV KL M + +E+ ++ A
Sbjct: 369 ASNAGGVAVSGLEMSQNAMRLRWSEGEVDTKLHGIMQSIHHACLLYGEEQGRVNYVKGAN 428
Query: 402 VVAVQRVYQAMLDRGWV 418
+ +V AML +G V
Sbjct: 429 IAGFVKVADAMLAQGVV 445
>emb|CAA75437.1| (Y15166) NADP-glutamate dehydrogenase [Pseudomonas aeruginosa]
>gi|4239791|emb|CAA77192.1| (Y18494) NADP-glutamate
dehydrogenase [Pseudomonas aeruginosa]
Length = 445
Score = 184 bits (463), Expect = 1e-45
Identities = 140/434 (32%), Positives = 211/434 (48%), Gaps = 24/434 (5%)
Query: 3 EQDPFEIAVKQLERA------AQYMKISEEALEFLKRPQRIVEVTIPVEMDDGSVKVFTG 56
+Q F AV+++ R+ A + +E + P+R + +P D G V+V G
Sbjct: 18 DQPEFHQAVEEVLRSLWPFLEANPHYLEAGIIERIVEPERAILFRVPWVDDQGRVRVNRG 77
Query: 57 FRVQYNWARGPTKGGIRWHPEETLSTVKALAAWMTWKTAVMDLPYGGGKGGIIVDPKKLS 116
+RVQ + A GP KGG+R+HP L +K LA +K ++ LP GGGKGG DPK S
Sbjct: 78 YRVQMSSAIGPYKGGLRFHPSVNLGVLKFLAFEQVFKNSLTTLPMGGGKGGSDFDPKGKS 137
Query: 117 DREKERLARGYIRAIYDVISPYEDIPAPDVYTNPQIMAWMMDEYETIARRKTPAFGIITG 176
D E R + ++ +Y + D+PA D+ + + ++ +Y+ ++ + T ++TG
Sbjct: 138 DAEVMRFCQSFMSELYRHVGADLDVPAGDIGVGAREIGYLFGQYKRLSNQFT---SVLTG 194
Query: 177 KPLSIGGSLGRNEATARGASYTIREAAKVLGWDDLKGKTIAIQGYGNAGYYLAKIMSEDY 236
K LS GGSL R EAT G Y +E K G G+ +AI G GN Y A+ + E
Sbjct: 195 KGLSYGGSLIRPEATGFGCVYFAQEMLKDRG-RGFDGQRVAISGSGNVAQYAARKVME-M 252
Query: 237 GMKVVAVSDSKGGIYNPDGLNADEVLKWKREHGSVKDFPGATNITNEELLELE------- 289
G KV+++SDS+G +Y GL +DE ++ E + + + L LE
Sbjct: 253 GGKVISLSDSEGTLYAEAGL-SDEQWEYLMELKNARAGHPRDGVEQFSLQFLEGVPPWGL 311
Query: 290 -VDVLAPAAIEEVITKKNADNIKAK---IVAEVANGPVTPEADEILFEKGILQIPDFLCN 345
D+ P A + + ++A + A VAE AN P T EA ++ E GIL P N
Sbjct: 312 ACDIALPCATQNELDAEDARRLLANGCVCVAEGANMPSTLEAVDLFLEAGILYAPGKASN 371
Query: 346 AGGVTVSYFEWVQNITGYYWTLEEVREKLDKKMTKAFYDVYNTAKEK-NIHMRDAAYVVA 404
AGGV VS E QN W+ EV KL M + +E+ ++ A +
Sbjct: 372 AGGVAVSGLEMSQNAMRLRWSEGEVDTKLHGIMQSIHHACLLYGEEQGRVNYVKGANIAG 431
Query: 405 VQRVYQAMLDRGWV 418
+V AML +G V
Sbjct: 432 FVKVADAMLAQGVV 445
>emb|CAB82051.1| (AL161803) NADP-specific glutamate dehydrogenase [Streptomyces
coelicolor A3(2)]
Length = 461
Score = 183 bits (461), Expect = 2e-45
Identities = 131/404 (32%), Positives = 194/404 (47%), Gaps = 23/404 (5%)
Query: 28 LEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQYNWARGPTKGGIRWHPEETLSTVKALA 87
+E L P+R V +P + D G V+V GFRV++N A GP KGG+R+HP L +K L
Sbjct: 64 IERLVEPERQVMFRVPWQDDQGRVRVNRGFRVEFNSALGPYKGGLRFHPSVNLGVIKFLG 123
Query: 88 AWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREKERLARGYIRAIYDVISPYEDIPAPDVY 147
+K A+ L GGGKGG DP SD E R + ++ +Y I + D+PA D+
Sbjct: 124 FEQIFKNALTGLGIGGGKGGSDFDPHGRSDAEVMRFCQSFMTELYRHIGEHTDVPAGDIG 183
Query: 148 TNPQIMAWMMDEYETIARRKTPAFGIITGKPLSIGGSLGRNEATARG----ASYTIREAA 203
+ + ++ +Y I R G++TGK GGSL R EAT G A+ +RE
Sbjct: 184 VGGREIGYLFGQYRRITNRWES--GVLTGKGQGWGGSLIRPEATGYGNVLFAAAMLRERG 241
Query: 204 KVLGWDDLKGKTIAIQGYGNAGYYLAKIMSEDYGMKVVAVSDSKGGIYNPDGLNADEVLK 263
+DL+G+T + G GN Y + ++ G V SDS G + + G++ D + +
Sbjct: 242 -----EDLEGQTAVVSGSGNVAIYTIEKLTA-LGANAVTCSDSSGYVVDEKGIDLDLLKQ 295
Query: 264 WKR-EHGSVKDF-----PGATNITNEELLELEVDVLAPAAIEEVITKKNADNI---KAKI 314
K E G V + A + + ++ D+ P+A + + + A + K
Sbjct: 296 IKEVERGRVDAYAERRGASARFVPGGSVWDVPADLALPSATQNELDENAAATLVRNGVKA 355
Query: 315 VAEVANGPVTPEADEILFEKGILQIPDFLCNAGGVTVSYFEWVQNITGYYWTLEEVREKL 374
V+E AN P TPEA +L + G+ P NAGGV VS E QN WT V E+L
Sbjct: 356 VSEGANMPTTPEAVHLLQKAGVAFGPGKAANAGGVAVSALEMAQNHARTSWTAARVEEEL 415
Query: 375 DKKMTKAFYDVYNTAKEKNI--HMRDAAYVVAVQRVYQAMLDRG 416
MT + TA+ + A + +RV AML +G
Sbjct: 416 ADIMTSIHTTCHETAERYDAPGDYVTGANIAGFERVADAMLAQG 459
>pir||T42429 probable glutamate dehydrogenase (NADP+) (EC 1.4.1.4) - fission
yeast (Schizosaccharomyces pombe) (fragment)
>gi|1749514|dbj|BAA13815.1| (D89153) similar to
Saccharomyces cerevisiae NADP-specific glutamate
dehydrogenase, SWISS-PROT Accession Number P39708
[Schizosaccharomyces pombe]
Length = 447
Score = 183 bits (459), Expect = 4e-45
Identities = 143/409 (34%), Positives = 201/409 (48%), Gaps = 43/409 (10%)
Query: 7 FEIAVKQLERAAQYMKISE------EALEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQ 60
F+ A K++ + + K+ E L + P+R++E + E D G+ +V TG+RVQ
Sbjct: 9 FQQAYKEIVGSIESSKLFEVHPELKRVLPIISIPERVLEFRVTWEDDKGNCRVNTGYRVQ 68
Query: 61 YNWARGPTKGGIRWHPEETLSTVKALAAWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREK 120
+N A GP KGG+R+HP LS +K L +K A+ LP GGGKGG DPK SD E
Sbjct: 69 FNSALGPYKGGLRFHPSVNLSILKFLGFEQIFKNALTGLPMGGGKGGSDFDPKGKSDNEI 128
Query: 121 ERLARGYIRAIYDVISPYEDIPAPDVYTNPQIMAWMMDEYETIARRKTPAFGIITGKPLS 180
R ++ ++R ++ I P D+PA D+ ++ M EY+ R + G++TGK +
Sbjct: 129 RRFSQAFMRQLFRYIGPQTDVPAGDIGVTGFVVMHMFGEYK---RLRNEYSGVVTGKHML 185
Query: 181 IGGSLGRNEATARGASYTIREAA--KVLGWDDLKGKTIAIQGYGNAGYYLA-KIMSEDYG 237
GGS R EAT G Y ++ + G + LKGK +AI G GN Y A K + E G
Sbjct: 186 TGGSNIRPEATGYGVVYYVKHMIEHRTKGAETLKGKRVAISGSGNVAQYAALKCIQE--G 243
Query: 238 MKVVAVSDSKGGIY--NPDGL---NADEVLKWKREHGSVKD----------FPGATNITN 282
V ++SDSKG + +GL E++ K + S+ D GA TN
Sbjct: 244 AIVKSISDSKGVLIAKTAEGLVPEEIHEIMALKEKRASIADSASLCKKHHYIAGARPWTN 303
Query: 283 EELLELEVDVLAPAAIE-EVITKKNADNIK--AKIVAEVANGPVTPEADEILFEK----- 334
E+D+ P A + EV ++ A IK + VAE +N + EA E+ FEK
Sbjct: 304 VG----EIDIALPCATQNEVSGEEAAALIKQGCRYVAEGSNMGSSAEAVEV-FEKSRASG 358
Query: 335 -GILQIPDFLCNAGGVTVSYFEWVQNITGYYWTLEEVREKLDKKMTKAF 382
G P NAGGV VS E QN WT EV KL M F
Sbjct: 359 EGCWLAPGKAANAGGVAVSGLEMAQNAQFSTWTHAEVDAKLAGIMQNIF 407
>pir||T41492 probable glutamate dehydrogenase (NADP+) (EC 1.4.1.4) - fission
yeast (Schizosaccharomyces pombe)
>gi|3821331|emb|CAA21868.1| (AL033127) nadp-specific
glutamate dehydrogenase [Schizosaccharomyces pombe]
Length = 451
Score = 183 bits (459), Expect = 4e-45
Identities = 143/409 (34%), Positives = 201/409 (48%), Gaps = 43/409 (10%)
Query: 7 FEIAVKQLERAAQYMKISE------EALEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQ 60
F+ A K++ + + K+ E L + P+R++E + E D G+ +V TG+RVQ
Sbjct: 9 FQQAYKEIVGSIESSKLFEVHPELKRVLPIISIPERVLEFRVTWEDDKGNCRVNTGYRVQ 68
Query: 61 YNWARGPTKGGIRWHPEETLSTVKALAAWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREK 120
+N A GP KGG+R+HP LS +K L +K A+ LP GGGKGG DPK SD E
Sbjct: 69 FNSALGPYKGGLRFHPSVNLSILKFLGFEQIFKNALTGLPMGGGKGGSDFDPKGKSDNEI 128
Query: 121 ERLARGYIRAIYDVISPYEDIPAPDVYTNPQIMAWMMDEYETIARRKTPAFGIITGKPLS 180
R ++ ++R ++ I P D+PA D+ ++ M EY+ R + G++TGK +
Sbjct: 129 RRFSQAFMRQLFRYIGPQTDVPAGDIGVTGFVVMHMFGEYK---RLRNEYSGVVTGKHML 185
Query: 181 IGGSLGRNEATARGASYTIREAA--KVLGWDDLKGKTIAIQGYGNAGYYLA-KIMSEDYG 237
GGS R EAT G Y ++ + G + LKGK +AI G GN Y A K + E G
Sbjct: 186 TGGSNIRPEATGYGVVYYVKHMIEHRTKGAETLKGKRVAISGSGNVAQYAALKCIQE--G 243
Query: 238 MKVVAVSDSKGGIY--NPDGL---NADEVLKWKREHGSVKD----------FPGATNITN 282
V ++SDSKG + +GL E++ K + S+ D GA TN
Sbjct: 244 AIVKSISDSKGVLIAKTAEGLVPEEIHEIMALKEKRASIADSASLCKKHHYIAGARPWTN 303
Query: 283 EELLELEVDVLAPAAIE-EVITKKNADNIK--AKIVAEVANGPVTPEADEILFEK----- 334
E+D+ P A + EV ++ A IK + VAE +N + EA E+ FEK
Sbjct: 304 VG----EIDIALPCATQNEVSGEEAAALIKQGCRYVAEGSNMGSSAEAVEV-FEKSRASG 358
Query: 335 -GILQIPDFLCNAGGVTVSYFEWVQNITGYYWTLEEVREKLDKKMTKAF 382
G P NAGGV VS E QN WT EV KL M F
Sbjct: 359 EGCWLAPGKAANAGGVAVSGLEMAQNAQFSTWTHAEVDAKLAGIMQNIF 407
>pir||A33504 glutamate dehydrogenase (NADP+) (EC 1.4.1.4) - Salmonella
typhimurium
Length = 447
Score = 182 bits (456), Expect = 9e-45
Identities = 137/420 (32%), Positives = 203/420 (47%), Gaps = 30/420 (7%)
Query: 14 LERAAQYMKISEEALEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQYNWARGPTKGGIR 73
LE+ +Y +S LE L P+R+++ + D V+V +RVQ+N A GP KGG+R
Sbjct: 39 LEQNPRYRHMS--LLERLVEPERVIQFRVVWLDDKNQVQVNRAWRVQFNSAIGPYKGGMR 96
Query: 74 WHPEETLSTVKALAAWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREKERLARGYIRAIYD 133
+HP LS +K L T+K A+ LP GGGKGG DPK S+ E R + + +Y
Sbjct: 97 FHPSVNLSILKFLGFEQTFKNALTTLPMGGGKGGSDFDPKGKSEGEVMRFCQALMTELYR 156
Query: 134 VISPYEDIPAPDVYTNPQIMAWMMDEYETIARRKTPAFGIITGKPLSIGGSLGRNEATAR 193
+ P D+PA D+ + + +M ++ + F TGK LS GGSL R EAT
Sbjct: 157 HLGPDTDVPAGDIGVGGREVGFMAGMMRKLSNNSSCVF---TGKGLSFGGSLIRPEATGY 213
Query: 194 GASYTIREAAKVLGWDDLKGKTIAIQGYGN-AGYYLAKIMSEDYGMKVVAVSDSKGGIYN 252
G Y K G +G +A+ G GN A Y + K M+ +G +VV SDS G + +
Sbjct: 214 GLVYFTEAMLKRHGL-GFEGMRVAVSGSGNVAQYAIEKAMA--FGARVVTASDSSGTVVD 270
Query: 253 PDGLNADEV-----LKWKREHGSVKDFP---GATNITNEELLELEVDVLAPAAIEEVITK 304
G +++ +K R+ G V D+ G T + ++ + VD+ P A + +
Sbjct: 271 ESGFTPEKLARLCEIKASRD-GRVADYAREFGLTYLEGQQPWSVPVDIALPCATQNELDV 329
Query: 305 KNADNIKA---KIVAEVANGPVTPEADEILFEKGILQIPDFLCNAGGVTVSYFEWVQNIT 361
A + A K VAE AN P T EA ++ E G+L P NAGGV S E QN
Sbjct: 330 DAARVLIANGVKAVAEGANMPTTIEATDLFLEAGVLFAPGKAANAGGVATSGLEMAQNAA 389
Query: 362 GYYWTLEEVREKLDKKMTKAFYDVYNTAKE-----KNIHMRDAAYVVAVQRVYQAMLDRG 416
W EK+D ++ D+++ E K+ + A + +V AML +G
Sbjct: 390 RLSWK----AEKVDARLHHIMLDIHHACVEYGGDNKHTNYVQGANIAGFVKVADAMLAQG 445
>sp|P15111|DHE4_SALTY NADP-SPECIFIC GLUTAMATE DEHYDROGENASE (NADP-GDH)
>gi|154085|gb|AAA27131.1| (M24021) glutamate
dehydrogenase (EC 1.4.1.4) [Salmonella typhimurium]
Length = 447
Score = 182 bits (456), Expect = 9e-45
Identities = 137/420 (32%), Positives = 203/420 (47%), Gaps = 30/420 (7%)
Query: 14 LERAAQYMKISEEALEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQYNWARGPTKGGIR 73
LE+ +Y +S LE L P+R+++ + D V+V +RVQ+N A GP KGG+R
Sbjct: 39 LEQNPRYRHMS--LLERLVEPERVIQFRVVWLDDKNQVQVNRAWRVQFNSAIGPYKGGMR 96
Query: 74 WHPEETLSTVKALAAWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREKERLARGYIRAIYD 133
+HP LS +K L T+K A+ LP GGGKGG DPK S+ E R + + +Y
Sbjct: 97 FHPSVNLSILKFLGFEQTFKNALTTLPMGGGKGGSDFDPKGKSEGEVMRFCQALMTELYR 156
Query: 134 VISPYEDIPAPDVYTNPQIMAWMMDEYETIARRKTPAFGIITGKPLSIGGSLGRNEATAR 193
+ P D+PA D+ + + +M ++ + F TGK LS GGSL R EAT
Sbjct: 157 HLGPDTDVPAGDIGVGGREVGFMAGMMRKLSNNSSCVF---TGKGLSFGGSLIRPEATGY 213
Query: 194 GASYTIREAAKVLGWDDLKGKTIAIQGYGN-AGYYLAKIMSEDYGMKVVAVSDSKGGIYN 252
G Y K G +G +A+ G GN A Y + K M+ +G +VV SDS G + +
Sbjct: 214 GLVYFTEAMLKRHGL-GFEGMRVAVSGSGNVAQYAIEKAMA--FGARVVTASDSSGTVVD 270
Query: 253 PDGLNADEV-----LKWKREHGSVKDFP---GATNITNEELLELEVDVLAPAAIEEVITK 304
G +++ +K R+ G V D+ G T + ++ + VD+ P A + +
Sbjct: 271 ESGFTPEKLARLCEIKASRD-GRVADYARDFGLTYLEGQQPWSVPVDIALPCATQNELDV 329
Query: 305 KNADNIKA---KIVAEVANGPVTPEADEILFEKGILQIPDFLCNAGGVTVSYFEWVQNIT 361
A + A K VAE AN P T EA ++ E G+L P NAGGV S E QN
Sbjct: 330 DAARVLIANGVKAVAEGANMPTTIEATDLFLEAGVLFAPGKAANAGGVATSGLEMAQNAA 389
Query: 362 GYYWTLEEVREKLDKKMTKAFYDVYNTAKE-----KNIHMRDAAYVVAVQRVYQAMLDRG 416
W EK+D ++ D+++ E K+ + A + +V AML +G
Sbjct: 390 RLSWK----AEKVDARLHHIMLDIHHACVEYGGDNKHTNYVQGANIAGFVKVADAMLAQG 445
>gb|AAC14692.1| (AF009365) glutamate dehydrogenase [Trypanosoma cruzi]
Length = 446
Score = 180 bits (452), Expect = 3e-44
Identities = 132/418 (31%), Positives = 208/418 (49%), Gaps = 23/418 (5%)
Query: 14 LERAAQYMKISEEALEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQYNWARGPTKGGIR 73
LE+ +Y + + LE L P+R+V+ + D G V+V +RV +N + GP KGG+R
Sbjct: 39 LEKHPEYCQ--DSLLERLVEPERVVQFRVSWVDDKGEVQVNRAWRVHFNSSIGPYKGGMR 96
Query: 74 WHPEETLSTVKALAAWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREKERLARGYIRAIYD 133
+HP LS +K L T+K ++ LP GGGKGG DPK SDRE R + + +Y
Sbjct: 97 FHPSVNLSILKFLGFEQTFKNSLTTLPMGGGKGGSDFDPKGKSDREVMRFCQALVTELYR 156
Query: 134 VISPYEDIPAPDVYTNPQIMAWMMDEYETIARRKTPAFGIITGKPLSIGGSLGRNEATAR 193
I P D+PA D+ + + +M + + K F TGK +S GS R EAT
Sbjct: 157 HIGPDTDVPAGDIGVGGREVGYMAGMTQKLTNNKACRF---TGKGISFQGSQMRPEATGY 213
Query: 194 GASYTIREAAKVLGWDDLKGKTIAIQGYGNAGYYLAKIMSEDYGMKVVAVSDSKGGIYNP 253
G Y + K +LKG T+ + G GN Y + + G KV++VSDS+G +++
Sbjct: 214 GVVYFLDALLKKHN-QELKGMTVVVSGSGNVAQYPVEKCLQ-LGAKVLSVSDSRGCVHDV 271
Query: 254 DGLNADE---VLKWKR-EHGSVKDFP---GATNITNEELLELEVDVLAPAAIEEVITKKN 306
+G ++ ++ K +HG+V+++ G + E ++ D+ P A + + ++
Sbjct: 272 EGFTPEKLKVLMDIKNVKHGTVEEYTKGLGLQYLRGETPWHIKADIALPCATQNELELED 331
Query: 307 ADNI---KAKIVAEVANGPVTPEADEILFEKGILQIPDFLCNAGGVTVSYFEWVQNITGY 363
A + +VAE AN P T +A G+L P NA GV +S E QN
Sbjct: 332 AKALIKNGVTVVAEGANMPTTTDATMEFINAGVLFAPGKAANARGVAISGLEMSQN-AAL 390
Query: 364 YWTLEEVREKLDKKMTKAFYDV---YNTAKEKNIHMRDAAYVVAVQRVYQAMLDRGWV 418
WT EEV +KL +++ + +D Y T K ++ + A + +V +AM G V
Sbjct: 391 SWTAEEVEQKL-REIMNSIHDACVKYGTVGGKTNYV-NGANIAGFVKVAEAMKGLGVV 446
>pir||B81825 glutamate dehydrogenase (NADP+) (EC 1.4.1.4) NMA1964 [imported] -
Neisseria meningitidis (group A strain Z2491)
>gi|7380596|emb|CAB85184.1| (AL162757) glutamate
dehydrogenase [Neisseria meningitidis Z2491]
Length = 444
Score = 179 bits (450), Expect = 5e-44
Identities = 136/432 (31%), Positives = 209/432 (47%), Gaps = 23/432 (5%)
Query: 4 QDPFEIAVKQLERA-----AQYMKISEEAL-EFLKRPQRIVEVTIPVEMDDGSVKVFTGF 57
Q+PF AV+++ + A+ K ++++L E + P+R+V + + D G V+V G+
Sbjct: 18 QEPFHQAVEEVFMSLDPFLAKNPKYTQQSLLERIVEPERVVMFRVTWQDDKGQVQVNRGY 77
Query: 58 RVQYNWARGPTKGGIRWHPEETLSTVKALAAWMTWKTAVMDLPYGGGKGGIIVDPKKLSD 117
RVQ + A GP KGG+R+HP L +K LA +K A+ LP GGGKGG DPK SD
Sbjct: 78 RVQMSSAIGPYKGGLRFHPTVDLGVLKFLAFEQVFKNALTTLPMGGGKGGSDFDPKGKSD 137
Query: 118 REKERLARGYIRAIYDVISPYEDIPAPDVYTNPQIMAWMMDEYETIARRKTPAFGIITGK 177
E R + ++ +Y I D+PA D+ + + ++ +Y+ I + ++TGK
Sbjct: 138 AEVMRFCQAFMTELYRHIGADTDVPAGDIGVGGREIGYLFGQYKKI---RNEFSSVLTGK 194
Query: 178 PLSIGGSLGRNEATARGASYTIREAAKVLGWDDLKGKTIAIQGYGNAGYYLAKIMSEDYG 237
L GGSL R EAT G Y + + D +GK + I G GN Y A+ + G
Sbjct: 195 GLEWGGSLIRPEATGYGCVYFAQAMLQTRN-DSFEGKRVLISGSGNVAQYAAE-KAIQLG 252
Query: 238 MKVVAVSDSKGGIYNPDGLNAD-------EVLKWKREH-GSVKDFPGATNITNEELLELE 289
KV+ VSDS G + PD ++ E+ + +RE + G N++ +
Sbjct: 253 AKVLTVSDSNGFVLFPDSGMSEAQLAALIELKEVRRERVATYAKEQGLQYFENQKPWGVA 312
Query: 290 VDVLAPAAIEEVITKKNADNIKAK---IVAEVANGPVTPEADEILFEKGILQIPDFLCNA 346
++ P A + + ++ A + A +VAE AN P T A E + GIL P NA
Sbjct: 313 AEIALPCATQNELDEEAAKTLLANGCYVVAEGANMPSTLGAVEQFIKAGILYAPGKASNA 372
Query: 347 GGVTVSYFEWVQNITGYYWTLEEVREKLDKKMTKAFYDVYNTAK-EKNIHMRDAAYVVAV 405
GGV S E QN WT EEV ++L M K ++ + A +
Sbjct: 373 GGVATSGLEMSQNAIRLSWTREEVDQRLFGIMQSIHESCLKYGKVGDTVNYVNGANIAGF 432
Query: 406 QRVYQAMLDRGW 417
+V AML +G+
Sbjct: 433 VKVADAMLAQGF 444
>pir||E75362 glutamate dehydrogenase - Deinococcus radiodurans (strain R1)
>gi|6459489|gb|AAF11275.1|AE002013_5 (AE002013)
glutamate dehydrogenase [Deinococcus radiodurans]
Length = 424
Score = 178 bits (447), Expect = 1e-43
Identities = 129/402 (32%), Positives = 199/402 (49%), Gaps = 19/402 (4%)
Query: 28 LEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQYNWARGPTKGGIRWHPEETLSTVKALA 87
LE L P+R++ + D G V+V G+RVQ++ + GP KGG+R+HP LS +K LA
Sbjct: 27 LERLIEPERVISFRVTWVDDAGQVQVNRGYRVQHSSSIGPYKGGMRFHPSVNLSILKFLA 86
Query: 88 AWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREKERLARGYIRAIYDVISPYEDIPAPDVY 147
T+K A+ LP GGGKGG DPK SD E R + + ++ + P D+PA D+
Sbjct: 87 FEQTFKNALTTLPLGGGKGGSDFDPKGKSDGEVMRFCQALMTELWRHLGPDTDVPAGDIG 146
Query: 148 TNPQIMAWMMDEYETIARRKTPAFGIITGKPLSIGGSLGRNEATARGASYTIREAAKVLG 207
+ + ++ + +A A G+ TGK LS GGSL R EAT G Y + +
Sbjct: 147 VGGREVGYLAGMMKKLANH---AGGVFTGKGLSYGGSLLRPEATGYGTVYFVEHMLRDQR 203
Query: 208 WDDLKGKTIAIQGYGNAGYYLAKIMSEDYGMKVVAVSDSKGGIYNPDGLNADE---VLKW 264
+++G +++ G GN Y + + G V+ S+S G + + DG D+ ++
Sbjct: 204 M-EMEGLRVSVSGSGNVAQYAIE-KALHLGAHVLTASNSGGTVVDEDGFTYDKLAVLMDI 261
Query: 265 KRE-HGSVKDFP---GATNITNEELLELEVDVLAPAAIEEVITKKNADNIKA---KIVAE 317
K E G V+D+ GA ++ VDV P A + + +A + A ++VAE
Sbjct: 262 KNERRGRVEDYAREVGAEFRPGVRPWDVPVDVALPCATQNELGADDARTLIAGGVRVVAE 321
Query: 318 VANGPVTPEADEILFEKGILQIPDFLCNAGGVTVSYFEWVQNITGYYWTLEEVREKLDKK 377
AN P A + E G+L P NAGGV S E QN WT EEV ++L +
Sbjct: 322 GANMPCDLAAIQAFEEAGVLYAPGKATNAGGVATSGLEMSQNAQRLSWTREEVDQRL-RS 380
Query: 378 MTKAFYD---VYNTAKEKNIHMRDAAYVVAVQRVYQAMLDRG 416
+ A +D Y ++++ D A + +V AM ++G
Sbjct: 381 IMSAIHDSCLEYGRRPDRHVSYLDGANIAGFVKVATAMREQG 422
>pir||H81050 glutamate dehydrogenase, NADP-specific NMB1710 [imported] -
Neisseria meningitidis (group B strain MD58)
>gi|7226965|gb|AAF42057.1| (AE002521) glutamate
dehydrogenase, NADP-specific [Neisseria meningitidis
MC58]
Length = 444
Score = 178 bits (447), Expect = 1e-43
Identities = 138/432 (31%), Positives = 205/432 (46%), Gaps = 23/432 (5%)
Query: 4 QDPFEIAVKQLERA-----AQYMKISEEAL-EFLKRPQRIVEVTIPVEMDDGSVKVFTGF 57
Q+PF AV+++ + A+ K ++++L E + P+R+V + + D G V+V G+
Sbjct: 18 QEPFHQAVEEVFMSLDPFLAKNPKYTQQSLLERIVEPERVVMFRVTWQDDKGQVQVNRGY 77
Query: 58 RVQYNWARGPTKGGIRWHPEETLSTVKALAAWMTWKTAVMDLPYGGGKGGIIVDPKKLSD 117
RVQ + A GP KGG+R+HP L +K LA +K A+ LP GGGKGG DPK SD
Sbjct: 78 RVQMSSAIGPYKGGLRFHPTVDLGVLKFLAFEQVFKNALTTLPMGGGKGGSDFDPKGKSD 137
Query: 118 REKERLARGYIRAIYDVISPYEDIPAPDVYTNPQIMAWMMDEYETIARRKTPAFGIITGK 177
E R + ++ +Y I D+PA D+ + + ++ +Y+ I + ++TGK
Sbjct: 138 AEVMRFCQAFMTELYRHIGADTDVPAGDIGVGGREIGYLFGQYKKI---RNEFSSVLTGK 194
Query: 178 PLSIGGSLGRNEATARGASYTIREAAKVLGWDDLKGKTIAIQGYGNAGYYLAKIMSEDYG 237
L GGSL R EAT G Y + + D +GK + I G GN Y A+ + G
Sbjct: 195 GLEWGGSLIRPEATGYGCVYFAQAMLQTRN-DSFEGKRVLISGSGNVAQYAAE-KAIQLG 252
Query: 238 MKVVAVSDSKGGIYNPDGLNADEVLKWKREHGSVKDFPGATNITNEELLELE-------- 289
KV+ VSDS G + PD + L E V+ AT + L E
Sbjct: 253 AKVLTVSDSNGFVLFPDSGMTEAQLAALIELKEVRRERVATYAKEQGLQYFEKQKPWGVA 312
Query: 290 VDVLAPAAIEEVITKKNADNIKAK---IVAEVANGPVTPEADEILFEKGILQIPDFLCNA 346
++ P A + + ++ A + A +VAE AN P T A E + GIL P NA
Sbjct: 313 AEIALPCATQNELDEEAAKTLLANGCYVVAEGANMPSTLGAVEQFIKAGILYAPGKASNA 372
Query: 347 GGVTVSYFEWVQNITGYYWTLEEVREKLDKKMTKAFYDVYNTAK-EKNIHMRDAAYVVAV 405
GGV S E QN WT EEV ++L M K ++ + A +
Sbjct: 373 GGVATSGLEMSQNAIRLSWTREEVDQRLFGIMQSIHESCLKYGKVGDTVNYVNGANIAGF 432
Query: 406 QRVYQAMLDRGW 417
+V AML +G+
Sbjct: 433 VKVADAMLAQGF 444
>gb|AAG28788.1|AF309087_1 (AF309087) NADP glutamate dehydrogenase [Tuber borchii]
Length = 457
Score = 178 bits (446), Expect = 1e-43
Identities = 127/386 (32%), Positives = 189/386 (48%), Gaps = 33/386 (8%)
Query: 34 PQRIVEVTIPVEMDDGSVKVFTGFRVQYNWARGPTKGGIRWHPEETLSTVKALAAWMTWK 93
P+R+++ + E D G+ +V G+RVQ+N A GP KGG+R+HP LS +K L T+K
Sbjct: 42 PERVIQFRVTWEDDKGNFQVNRGYRVQFNSALGPYKGGLRFHPTVNLSILKFLGFEQTFK 101
Query: 94 TAVMDLPYGGGKGGIIVDPKKLSDREKERLARGYIRAIYDVISPYEDIPAPDVYTNPQIM 153
A+ L GGGKGG DPK SD E R ++R + I + D+PA D+ + +
Sbjct: 102 NALTGLNMGGGKGGSDFDPKGKSDNEIRRFCYSFMRELSKHIGQFTDVPAGDIGVGGREI 161
Query: 154 AWMMDEYETIARRKTPAFGIITGKPLSIGGSLGRNEATARGASYTIREAAKVL--GWDDL 211
++ YE+ K G++TGK ++ GGSL R EAT G Y + G +
Sbjct: 162 GYLFGAYESY---KNQFEGVLTGKGITWGGSLIRPEATGYGLVYYVAHMISYASGGKETF 218
Query: 212 KGKTIAIQGYGNAGYYLA-KIMSEDYGMKVVAVSDSKGGIY--NPDGLNADE---VLKWK 265
GK +AI G GN Y A K++ + G KV+ +SDSKG + +G N + + K K
Sbjct: 219 AGKRVAISGSGNVAQYAALKVL--ELGGKVITLSDSKGALIATGEEGFNETDIELIAKLK 276
Query: 266 REHGSVKDFPGATNITNEELLEL----------EVDVLAPAAIEEVITKKNADNIKA--- 312
+ G + A + L +VDV P+A + ++++ A + A
Sbjct: 277 LDRGYLTQLHAAEDSFKSRFKYLPGERPWCHVDKVDVALPSATQNEVSEQEAKELIASGC 336
Query: 313 KIVAEVANGPVTPEADEILFE-------KGILQIPDFLCNAGGVTVSYFEWVQNITGYYW 365
K +AE +N T EA + E G+ P N GGV VS E QN W
Sbjct: 337 KFLAEGSNMGSTQEAINVYEEDRKSRKADGLWYGPAKAANCGGVAVSGLEMAQNSQRLTW 396
Query: 366 TLEEVREKLDKKMTKAFYDVYNTAKE 391
T E+V ++L M + F++ N AKE
Sbjct: 397 TSEQVDKELAGIMERCFWNCLNPAKE 422
>gb|AAF98446.1| (AY005438) NADP-dependent glutamate dehydrogenase [Debaryomyces
hansenii]
Length = 418
Score = 177 bits (445), Expect = 2e-43
Identities = 136/411 (33%), Positives = 197/411 (47%), Gaps = 36/411 (8%)
Query: 7 FEIAVKQLERAAQYMKISEEALEFLKR------PQRIVEVTIPVEMDDGSVKVFTGFRVQ 60
F+ A +L A + + E E+ K P+RI++ + E D+G V+V G+RVQ
Sbjct: 9 FQQAYNELVSALEDSTLFTEKPEYKKVIPVVSVPERIIQFRVAWENDNGDVEVNNGYRVQ 68
Query: 61 YNWARGPTKGGIRWHPEETLSTVKALAAWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREK 120
+N A GP KGG+R+HP LS +K L +K A+ L GGGKGG +PK +D E
Sbjct: 69 FNSALGPFKGGLRFHPSVNLSILKFLGFEQIFKNALTGLSMGGGKGGCDFNPKGRTDSEI 128
Query: 121 ERLARGYIRAIYDVISPYEDIPAPDVYTNPQIMAWMMDEYETIARRKTPAFGIITGKPLS 180
R ++R + I D+PA D+ + + +M Y+ + + GI+TGK LS
Sbjct: 129 RRFCVAFMRQLARYIGSDTDVPAGDIGVGSREVGYMFGAYKQMQNNWS---GILTGKGLS 185
Query: 181 IGGSLGRNEATARGASYTIREAAKVL--GWDDLKGKTIAIQGYGNAGYYLAKIMSEDYGM 238
GGSL R EAT G Y + + + G + KGK +AI G GN Y A + E G
Sbjct: 186 WGGSLIRPEATGYGVVYFVEKMIEKATGGKESFKGKRVAISGSGNVAQYAALKVIE-LGS 244
Query: 239 KVVAVSDSKGGIYNPDGLNADEV-------LKWKREHGSVKDFPGATNITNEELLEL--- 288
VV++SDSKG I + G+ D++ + +K K+ + +NE
Sbjct: 245 TVVSLSDSKGCIISQTGITPDQIKAIAAAKIHFKTLEEITKESASLFSGSNEVQYIAGVR 304
Query: 289 ------EVDVLAPAAIEEVITKKNADNI---KAKIVAEVANGPVTPEADEILFE----KG 335
+VDV P+A + ++ + A + K VAE +N T EA ++ FE K
Sbjct: 305 PWTHCGQVDVALPSATQNEVSGEEAKALVEAGCKYVAEGSNMGSTKEAIDV-FEANRSKA 363
Query: 336 ILQIPDFLCNAGGVTVSYFEWVQNITGYYWTLEEVREKLDKKMTKAFYDVY 386
+ P N GGV VS E QN W EEV EKL M F + Y
Sbjct: 364 VWYAPGKAANCGGVAVSGLEMAQNSQRVTWAAEEVDEKLKNIMYTCFDNCY 414
>gi|6319256 NADP-linked glutamate dehydrogenase; Gdh3p [Saccharomyces
cerevisiae] >gi|729323|sp|P39708|DHE5_YEAST
NADP-SPECIFIC GLUTAMATE DEHYDROGENASE 2 (NADP-GDH 2)
>gi|1077491|pir||S51960 glutamate dehydrogenase (NADP+)
(EC 1.4.1.4) GDH3 - yeast (Saccharomyces cerevisiae)
>gi|595524|gb|AAC04972.1| (U12980) Gdh3p: NADP-glutamate
dehydrogenase homolog [Saccharomyces cerevisiae]
Length = 457
Score = 177 bits (444), Expect = 2e-43
Identities = 139/441 (31%), Positives = 207/441 (46%), Gaps = 44/441 (9%)
Query: 12 KQLERAAQYMKISEEALEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQYNWARGPTKGG 71
K E+ QY K+ L + P+RI++ + E D+G +V G+RVQ+N A+GP KGG
Sbjct: 22 KIFEKFPQYKKV----LPIVSVPERIIQFRVTWENDNGEQEVAQGYRVQFNSAKGPYKGG 77
Query: 72 IRWHPEETLSTVKALAAWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREKERLARGYIRAI 131
+R+HP LS +K L +K A+ L GGGKGG+ VD K SD E R+ ++R +
Sbjct: 78 LRFHPSVNLSILKFLGFEQIFKNALTGLDMGGGKGGLCVDLKGKSDNEIRRICYAFMREL 137
Query: 132 YDVISPYEDIPAPDVYTNPQIMAWMMDEYETIARRKTPAFGIITGKPLSIGGSLGRNEAT 191
I D+PA D+ + + ++ Y + K G++TGK L+ GGSL R EAT
Sbjct: 138 SRHIGKDTDVPAGDIGVGGREIGYLFGAYRSY---KNSWEGVLTGKGLNWGGSLIRPEAT 194
Query: 192 ARGASYTIREAAKVL--GWDDLKGKTIAIQGYGNAGYYLAKIMSEDYGMKVVAVSDSKGG 249
G Y + G + +GK + I G GN Y A + E G+ VV++SDSKG
Sbjct: 195 GFGLVYYTQAMIDYATNGKESFEGKRVTISGSGNVAQYAALKVIELGGI-VVSLSDSKGC 253
Query: 250 IYNPDGLNAD---EVLKWKREHGSVKDFPGATNITNEELLEL-----------EVDVLAP 295
I + G+ ++ ++ K S+++ + +E ++ VD+ P
Sbjct: 254 IISETGITSEQIHDIASAKIRFKSLEEIVDEYSTFSESKMKYVAGARPWTHVSNVDIALP 313
Query: 296 AAIEEVITKKNADNIKA---KIVAEVANGPVTPEADEIL---------FEKGILQIPDFL 343
A + ++ A + A K VAE AN TPEA + + + P
Sbjct: 314 CATQNEVSGDEAKALVASGVKFVAEGANMGSTPEAISVFETARSTATNAKDAVWFGPPKA 373
Query: 344 CNAGGVTVSYFEWVQNITGYYWTLEEVREKLDKKMTKAFYDV------YNTAKEKNI--H 395
N GGV VS E QN WT E V ++L K M F D Y+T K N
Sbjct: 374 ANLGGVAVSGLEMAQNSQKVTWTAERVDQELKKIMINCFNDCIQAAQEYSTEKNTNTLPS 433
Query: 396 MRDAAYVVAVQRVYQAMLDRG 416
+ A + + V AMLD+G
Sbjct: 434 LVKGANIASFVMVADAMLDQG 454
>sp|P14657|DHE4_UNKP NADP-SPECIFIC GLUTAMATE DEHYDROGENASE (NADP-GDH)
>gi|77469|pir||S06938 glutamate dehydrogenase (NADP+)
(EC 1.4.1.4) - unidentified bacterium
>gi|48559|emb|CAA34434.1| (X16399) glutamate
dehydrogenase (AA 1-446) [unidentified bacterium]
Length = 446
Score = 176 bits (443), Expect = 3e-43
Identities = 132/418 (31%), Positives = 198/418 (46%), Gaps = 27/418 (6%)
Query: 14 LERAAQYMKISEEALEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQYNWARGPTKGGIR 73
+ER Y + + LE L P+RI++ + D G V+V FRVQ+N A GP KGG+R
Sbjct: 39 IERNPAYRE--QALLERLVEPERIIQFRVSWVDDRGQVQVNRAFRVQFNSAIGPYKGGMR 96
Query: 74 WHPEETLSTVKALAAWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREKERLARGYIRAIYD 133
+HP LS +K L T+K A+ LP GGGKGG DPK S R + + +Y
Sbjct: 97 FHPSVNLSILKFLGFEQTFKNALTTLPMGGGKGGSDFDPKGKSQGRIMRFCQALMTELYR 156
Query: 134 VISPYEDIPAPDVYTNPQIMAWMMDEYETIARRKTPAFGIITGKPLSIGGSLGRNEATAR 193
+ P D+PA D+ + + +M + ++ F TGK LS GGSL R EAT
Sbjct: 157 HLGPDTDVPAGDIGDGGREVGFMAGMMKKLSNNTACVF---TGKGLSFGGSLIRPEATGY 213
Query: 194 GASYTIREAAKVLGWDDLKGKTIAIQGYGN-AGYYLAKIMSEDYGMKVVAVSDSKGGIYN 252
G Y + G +G +A+ G GN A Y + K + D +V+ VSDS G + +
Sbjct: 214 GLVYFTDAMLQRHGL-GFEGMRVAVSGSGNVAQYTIEKALELD--ARVITVSDSGGTLVD 270
Query: 253 PDGLNADEVLKW----KREHGSVKDFP---GATNITNEELLELEVDVLAPAAIEEVITKK 305
DG +++ + +G V D+ G T + ++ + VD+ P A + + +
Sbjct: 271 EDGFTTEKLAHLAEIKNQRYGRVADYAAERGLTYLAGQQPWNVPVDIALPCATQNELDLE 330
Query: 306 NADNIK--AKIVAEVANGPVTPEADEILFEKGILQIPDFLCNAGGVTVSYFEWVQNITGY 363
A I+ K VAE AN P T +A + + G+L P NA G+ S E QN
Sbjct: 331 AARVIRNGVKAVAEGANMPTTIQATDAFLDAGVLFAPGKAANAAGLATSGLEMAQNAARI 390
Query: 364 YWTLEEVREKLDKKMTKAFYDVYNTAKE-----KNIHMRDAAYVVAVQRVYQAMLDRG 416
W EK+D ++ D+++ E K H A + +V +AML +G
Sbjct: 391 GWR----AEKVDVRLQHIMADIHHACVEYGGEGKQTHYVHGANIAGFVKVAEAMLAQG 444
>gb|AAF00006.1|AF056974_1 (AF056974) glutamate dehydrogenase [Penicillium chrysogenum]
Length = 461
Score = 173 bits (435), Expect = 3e-42
Identities = 139/434 (32%), Positives = 205/434 (47%), Gaps = 51/434 (11%)
Query: 1 MVEQDPFEIAVKQ--------LERAAQYMKISE--EALEFLKRPQRIVEVTIPVEMDDGS 50
M++ PFE +Q LE + + K E +AL+ + P+R+++ + E D G
Sbjct: 1 MMQNLPFEPEFEQAYKELASTLENSTLFQKKPEYRKALQVVSVPERVIQFRVVWEDDKGQ 60
Query: 51 VKVFTGFRVQYNWARGPTKGGIRWHPEETLSTVKALAAWMTWKTAVMDLPYGGGKGGIIV 110
V++ G+RVQ+N A GP KGG+R+HP LS +K L +K A+ L GGGKGG
Sbjct: 61 VQINRGYRVQFNSALGPYKGGLRFHPTVNLSILKFLGFEQIFKNALTGLNMGGGKGGSDF 120
Query: 111 DPKKLSDREKERLARGYIRAIYDVISPYEDIPAPDVYTNPQIMAWMMDEYETIARRKTPA 170
DPK +D E R ++ + I D+PA D+ + + +M +Y+ I +
Sbjct: 121 DPKGKTDNEIRRFCVSFMTELCKHIGADTDVPAGDIGVTGREVGFMFGQYKKIRNQWE-- 178
Query: 171 FGIITGKPLSIGGSLGRNEATARGASYTIREAAKVL--GWDDLKGKTIAIQGYGNAGYYL 228
G++TGK S GGSL R EAT G Y + + G + GK +AI G GN Y
Sbjct: 179 -GVLTGKGGSWGGSLIRPEATGYGVVYYVEHMIQHASGGKESFAGKRVAISGSGNVAQYA 237
Query: 229 AKIMSEDYGMKVVAVSDSKG--------GIYNPDGLNADEVLKWKREH-----------G 269
A + E G V+++SDS+G G + + +N +K +R+
Sbjct: 238 ALKVIE-LGGSVISLSDSQGALVLNGEEGSFTAEEINTIAEIKVQRKQIAELATQDAFSS 296
Query: 270 SVKDFPGATNITNEELLELEVDVLAPAAIEEVITKKNADNIKA---KIVAEVANGPVTPE 326
K PGA TN + +DV P+A + ++ A + A K +AE +N T E
Sbjct: 297 KFKYIPGARPWTN---IAGRIDVALPSATQNEVSGDEAKALIAAGCKFIAEGSNMGSTQE 353
Query: 327 ADEILFE---------KGILQIPDFLCNAGGVTVSYFEWVQNITGYYWTLEEVREKLDKK 377
A ++ FE I P NAGGV VS E QN W+ EEV +L K
Sbjct: 354 AIDV-FEAHRDANPGAAAIWYAPGKAANAGGVAVSGLEMAQNSARVNWSREEVDSRLKKI 412
Query: 378 MTKAFYDVYNTAKE 391
M F + +TAKE
Sbjct: 413 MEDCFNNGLSTAKE 426
>sp|P00370|DHE4_ECOLI NADP-SPECIFIC GLUTAMATE DEHYDROGENASE (NADP-GDH)
>gi|66085|pir||DEECEN glutamate dehydrogenase (NADP+)
(EC 1.4.1.4) - Escherichia coli
>gi|41544|emb|CAA25495.1| (X00988) glutamate
dehydrogenase [Escherichia coli]
>gi|146124|gb|AAA87979.1| (J01615) glutamate
dehydrogenase [Escherichia coli]
>gi|1742869|dbj|BAA15550.1| (D90819) NADP-specific
glutamate dehydrogenase (EC 1.4.1.4) (NADP-GDH).
[Escherichia coli] >gi|1788059|gb|AAC74831.1| (AE000271)
NADP-specific glutamate dehydrogenase [Escherichia coli
K12]
Length = 447
Score = 173 bits (434), Expect = 3e-42
Identities = 131/420 (31%), Positives = 201/420 (47%), Gaps = 30/420 (7%)
Query: 14 LERAAQYMKISEEALEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQYNWARGPTKGGIR 73
LE+ +Y ++S LE L P+R+++ + D ++V +RVQ++ A GP KGG+R
Sbjct: 39 LEQNPKYRQMS--LLERLVEPERVIQFRVVWVDDRNQIQVNRAWRVQFSSAIGPYKGGMR 96
Query: 74 WHPEETLSTVKALAAWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREKERLARGYIRAIYD 133
+HP LS +K L T+K A+ LP GGGKGG DPK S+ E R + + +Y
Sbjct: 97 FHPSVNLSILKFLGFEQTFKNALTTLPMGGGKGGSDFDPKGKSEGEVMRFCQALMTELYR 156
Query: 134 VISPYEDIPAPDVYTNPQIMAWMMDEYETIARRKTPAFGIITGKPLSIGGSLGRNEATAR 193
+ D+PA D+ + + +M + ++ F TGK LS GGSL R EAT
Sbjct: 157 HLGADTDVPAGDIGVGGREVGFMAGMMKKLSNNTACVF---TGKGLSFGGSLIRPEATGY 213
Query: 194 GASYTIREAAKVLGWDDLKGKTIAIQGYGN-AGYYLAKIMSEDYGMKVVAVSDSKGGIYN 252
G Y K G +G +++ G GN A Y + K M ++G +V+ SDS G + +
Sbjct: 214 GLVYFTEAMLKRHGM-GFEGMRVSVSGSGNVAQYAIEKAM--EFGARVITASDSSGTVVD 270
Query: 253 PDGLNADEV-----LKWKREHGSVKDFP---GATNITNEELLELEVDVLAPAAIEEVITK 304
G +++ +K R+ G V D+ G + ++ L VD+ P A + +
Sbjct: 271 ESGFTKEKLARLIEIKASRD-GRVADYAKEFGLVYLEGQQPWSLPVDIALPCATQNELDV 329
Query: 305 KNADNIKA---KIVAEVANGPVTPEADEILFEKGILQIPDFLCNAGGVTVSYFEWVQNIT 361
A + A K VAE AN P T EA E+ + G+L P NAGGV S E QN
Sbjct: 330 DAAHQLIANGVKAVAEGANMPTTIEATELFQQAGVLFAPGKAANAGGVATSGLEMAQNAA 389
Query: 362 GYYWTLEEVREKLDKKMTKAFYDVYNTAKE-----KNIHMRDAAYVVAVQRVYQAMLDRG 416
W EK+D ++ D+++ E + + A + +V AML +G
Sbjct: 390 RLGWK----AEKVDARLHHIMLDIHHACVEHGGEGEQTNYVQGANIAGFVKVADAMLAQG 445
>gb|AAC14691.1| (AF009364) glutamate dehydrogenase [Trypanosoma cruzi]
Length = 446
Score = 173 bits (433), Expect = 4e-42
Identities = 135/436 (30%), Positives = 209/436 (46%), Gaps = 31/436 (7%)
Query: 4 QDPFEIAVKQ--------LERAAQYMKISEEALEFLKRPQRIVEVTIPVEMDDGSVKVFT 55
Q FE AV + LE+ +Y + + LE L P+R+V+ + D G V+V
Sbjct: 21 QPEFEQAVHEVMTSLWPFLEKHPEYCQ--DSLLERLVEPERVVQFRVSWVDDKGEVQVNR 78
Query: 56 GFRVQYNWARGPTKGGIRWHPEETLSTVKALAAWMTWKTAVMDLPYGGGKGGIIVDPKKL 115
+RV +N + GP KGG+R+HP LS +K L T+K ++ LP GGGKGG DPK
Sbjct: 79 AWRVHFNSSIGPYKGGMRFHPSVNLSILKFLGFEQTFKNSLTTLPMGGGKGGSDFDPKGK 138
Query: 116 SDREKERLARGYIRAIYDVISPYEDIPAPDVYTNPQIMAWMMDEYETIARRKTPAFGIIT 175
SD E R + + +Y + D+PA D+ + + +M + + K F T
Sbjct: 139 SDGEVMRFFQALMTELYRHLGADTDVPAGDIGVGGREVGYMAGMTQKLTNNKACRF---T 195
Query: 176 GKPLSIGGSLGRNEATARGASYTIREAAKVLGWDDLKGKTIAIQGYGNAGYYLAKIMSED 235
GK +S GS R EAT G Y + K +LKG T+ + G GN Y K +
Sbjct: 196 GKGISFQGSQMRPEATGYGVVYFLDALLKKHN-QELKGMTVVVSGSGNVAQYAVKKCLQ- 253
Query: 236 YGMKVVAVSDSKGGIYNPDGLNADE---VLKWKR-EHGSVKDFP---GATNITNEELLEL 288
G KV++VSDS G + + G ++ ++ K +HG+V+++ G + E +
Sbjct: 254 LGEKVLSVSDSSGTVVDESGFTKEKLKVLMDIKNVKHGTVEEYAKGLGLQYLRGETPWHI 313
Query: 289 EVDVLAPAAIEEVITKKNADNI---KAKIVAEVANGPVTPEADEILFEKGILQIPDFLCN 345
+ D+ P A + + ++A + +VAE AN P T +A G+L P N
Sbjct: 314 KADIALPCATQNELELEDAKALIKNGVTVVAEGANMPTTTDATMEFINAGVLFAPGKAAN 373
Query: 346 AGGVTVSYFEWVQNITGYYWTLEEVREKLDKKMTKAFYDV---YNTAKEKNIHMRDAAYV 402
A GV +S E QN WT EEV +KL +++ + +D Y T K ++ + A +
Sbjct: 374 AXGVAISGLEMSQN-AALSWTAEEVEQKL-REIMNSIHDACVKYGTVGGKTNYV-NGANI 430
Query: 403 VAVQRVYQAMLDRGWV 418
+V +AM G V
Sbjct: 431 AGFVKVAEAMKGLGVV 446
>gb|AAA23868.1| (K02499) glutamate dehydrogenase [Escherichia coli]
Length = 447
Score = 172 bits (432), Expect = 6e-42
Identities = 131/420 (31%), Positives = 201/420 (47%), Gaps = 30/420 (7%)
Query: 14 LERAAQYMKISEEALEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQYNWARGPTKGGIR 73
LE+ +Y ++S LE L P+R+++ + D ++V +RVQ++ A GP KGG+R
Sbjct: 39 LEQNPKYRQMS--LLERLVEPERVIQFRVVWVDDRNQIQVNRAWRVQFSSAIGPYKGGMR 96
Query: 74 WHPEETLSTVKALAAWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREKERLARGYIRAIYD 133
+HP LS +K L T+K A+ LP GGGKGG DPK S+ E R + + +Y
Sbjct: 97 FHPSVNLSILKFLGFEQTFKNALTTLPMGGGKGGSDFDPKGKSEGEVMRFCQALMTELYR 156
Query: 134 VISPYEDIPAPDVYTNPQIMAWMMDEYETIARRKTPAFGIITGKPLSIGGSLGRNEATAR 193
+ D+PA D+ + + +M + ++ F TGK LS GGSL R EAT
Sbjct: 157 HLGADTDVPAGDIGVGGREVGFMAGMMKKLSNNTACVF---TGKGLSFGGSLIRPEATGY 213
Query: 194 GASYTIREAAKVLGWDDLKGKTIAIQGYGN-AGYYLAKIMSEDYGMKVVAVSDSKGGIYN 252
G Y K G +G +++ G GN A Y + K M ++G +V+ SDS G + +
Sbjct: 214 GLVYFTEAMLKRHGM-GFEGMRVSVSGSGNVAQYAIEKAM--EFGARVITASDSSGTVVD 270
Query: 253 PDGLNADEV-----LKWKREHGSVKDFP---GATNITNEELLELEVDVLAPAAIEEVITK 304
G +++ +K R+ G V D+ G + ++ L VD+ P A + +
Sbjct: 271 ESGFTKEKLARLIEIKASRD-GRVADYAKEFGLVYLEGQQPWSLPVDIALPCATQNELDV 329
Query: 305 KNADNIKA---KIVAEVANGPVTPEADEILFEKGILQIPDFLCNAGGVTVSYFEWVQNIT 361
A + A K VAE AN P T EA E+ + G+L P NAGGV S E QN
Sbjct: 330 DAAHQLIANGVKAVAEGANMPTTIEATELFQQAGVLFAPGKAANAGGVATSGLEMPQNAA 389
Query: 362 GYYWTLEEVREKLDKKMTKAFYDVYNTAKE-----KNIHMRDAAYVVAVQRVYQAMLDRG 416
W EK+D ++ D+++ E + + A + +V AML +G
Sbjct: 390 RLGWK----AEKVDARLHHIMLDIHHACVEHGGEGEQTNYVQGANIAGFVKVADAMLAQG 445
>gb|AAA34642.1| (M10590) glutamate dehydrogenase [Saccharomyces cerevisiae]
>gi|224706|prf||1111238A dehydrogenase,NADP specific Glu
[Saccharomyces cerevisiae]
Length = 453
Score = 171 bits (429), Expect = 1e-41
Identities = 138/452 (30%), Positives = 209/452 (45%), Gaps = 47/452 (10%)
Query: 4 QDPFEIAVKQLERAAQYMKISE--EALEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQY 61
Q +E V LE + + + E + L + P+RI++ + E D G +V G+RVQY
Sbjct: 7 QQAYEEVVSSLEDSTLFEQHPEYRKVLPIVSVPERIIQFRVTWENDKGEQEVAQGYRVQY 66
Query: 62 NWARGPTKGGIRWHPEETLSTVKALAAWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREKE 121
N A+GP KGG+R+HP LS +K L +K ++ L GGGKGG+ VD K S+ E
Sbjct: 67 NSAKGPYKGGLRFHPSVNLSILKFLGFEQIFKNSLTGLDMGGGKGGLCVDLKGRSNNEIR 126
Query: 122 RLARGYIRAIYDVISPYEDIPAPDVYTNPQIMAWMMDEYETIARRKTPAFGIITGKPLSI 181
R+ ++R + I D+PA D+ + + ++ Y + K G++TGK L+
Sbjct: 127 RICYAFMRELSRHIGQDTDVPAGDIGVGGREIGYLFGAYRSY---KNSWEGVLTGKGLNW 183
Query: 182 GGSLGRNEATARGASYTIREAAKVL--GWDDLKGKTIAIQGYGNAGYYLAKIMSEDYGMK 239
GGSL R EAT G Y + G + +GK + I G GN Y A + E G
Sbjct: 184 GGSLIRPEATGYGLVYYTQAMIDYATNGKESFEGKRVTISGSGNVAQYAALKVIE-LGGT 242
Query: 240 VVAVSDSKGGIYNPDGLNADEVLKWKREHGSVK-DFPGATNITNEELLELE--------- 289
VV++SDSKG I + G+ +++V + S K +F I NE E
Sbjct: 243 VVSLSDSKGCIISETGITSEQV----ADISSAKVNFKSLEQIVNEYSTFSENKVQYIAGA 298
Query: 290 --------VDVLAPAAIEEVITKKNADNIKA---KIVAEVANGPVTPEADEI-------- 330
VD+ P A + ++ + A + A K +AE +N TPEA +
Sbjct: 299 RPWTHVQKVDIALPCATQNEVSGEEAKALVAQGVKFIAEGSNMGSTPEAIAVFETARSTP 358
Query: 331 LFEKGILQIPDFLCNAGGVTVSYFEWVQNITGYYWTLEEVREKLDKKMTKAFYDVYNTAK 390
L + + P N GGV VS E QN WT E V ++L + M F + + AK
Sbjct: 359 LDQATVWYGPPKAANLGGVAVSGLEMAQNSQRITWTSERVDQELKRIMINCFNECIDYAK 418
Query: 391 EKN------IHMRDAAYVVAVQRVYQAMLDRG 416
+ + A + + +V AM D+G
Sbjct: 419 KYTKDGKVLPSLVKGANIASFIKVSDAMFDQG 450
>sp|P29507|DHE4_DEBOC NADP-SPECIFIC GLUTAMATE DEHYDROGENASE (NADP-GDH)
>gi|101730|pir||S17907 glutamate dehydrogenase (NADP+)
(EC 1.4.1.4) - yeast (Schwanniomyces occidentalis var.
occidentalis) >gi|238590|gb|AAB20267.1| (S64476)
NADP-dependent glutamate dehydrogenase, GDH
[Schwanniomyces occidentalis, Peptide, 459 aa]
[Debaryomyces occidentalis]
Length = 459
Score = 170 bits (427), Expect = 2e-41
Identities = 141/451 (31%), Positives = 217/451 (47%), Gaps = 45/451 (9%)
Query: 4 QDPFEIAVKQLERAAQYMKISE--EALEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQY 61
Q + V LE + + + E + + + P+RI++ + E D+G V+V GFRVQ+
Sbjct: 13 QQAYNELVSALEESTLFTEKPEYKKVIPVVSIPERIIQFRVAWENDNGDVEVNNGFRVQF 72
Query: 62 NWARGPTKGGIRWHPEETLSTVKALAAWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREKE 121
N + GP KGG+R+HP LS +K L +K A+ L GGGKGG +PK SD E
Sbjct: 73 NSSLGPYKGGLRFHPSVNLSILKFLGFEQIFKNALTGLSMGGGKGGCDFNPKGRSDGEIR 132
Query: 122 RLARGYIRAIYDVISPYEDIPAPDVYTNPQIMAWMMDEYETIARRKTPAFGIITGKPLSI 181
R ++R + I D+PA D+ + + ++ Y+ + + +G++TGK L+
Sbjct: 133 RFCVAFMRQLARYIGADTDVPAGDIGVGGREIGYLFGAYK---QMQNNWYGVLTGKGLTW 189
Query: 182 GGSLGRNEATARGASYTIREAAK--VLGWDDLKGKTIAIQGYGNAGYYLAKIMSEDYGMK 239
GGSL R EAT + T+++ + G + KGK + + G GN Y A + E G+
Sbjct: 190 GGSLIRPEATGYVSFTTLKKMIEKATNGKESFKGKRVELSGSGNVAQYAALKVIELGGI- 248
Query: 240 VVAVSDSKGGIYNPDGLNADEV-------LKWKR----EHGSVKDFPGATNITNEELLEL 288
VV++SDSKG I + +G+ ++V LK+K SVK F G ++ E L +
Sbjct: 249 VVSLSDSKGSIVSKNGIVPEQVLEIAAAKLKFKSLEEITKESVKLFSGENSV--EYLAGV 306
Query: 289 -------EVDVLAPAAIEEVIT----KKNADNIKAKIVAEVANGPVTPEADEILFE---- 333
DV P+A ++ ++ K K +AE +N T EA ++ FE
Sbjct: 307 RPWAKVGHFDVALPSATQKEVSGEEEAKALVEAGCKYIAEGSNMGSTKEAIDV-FEANRS 365
Query: 334 KGILQIPDFLCNAGGVTVSYFEWVQNITGYYWTLEEVREKLDKKMTKAFYDVYNTA---- 389
+ P N GGV VS E QN W+ EEV KL M F + Y+ A
Sbjct: 366 NNVWYAPGKAANCGGVAVSGLEMAQNSQRVQWSAEEVDAKLKNIMYTCFDNCYDPAIKYS 425
Query: 390 KEKNI----HMRDAAYVVAVQRVYQAMLDRG 416
EKN + A + + +V AM D+G
Sbjct: 426 AEKNADGLPSLLKGANIASFIKVADAMFDQG 456
>gi|6324951 NADP-specific glutamate dehydrogenase; Gdh1p [Saccharomyces
cerevisiae] >gi|2506355|sp|P07262|DHE4_YEAST
NADP-SPECIFIC GLUTAMATE DEHYDROGENASE 1 (NADP-GDH 1)
>gi|2144341|pir||A25275 glutamate dehydrogenase (NADP+)
(EC 1.4.1.4) - yeast (Saccharomyces cerevisiae)
>gi|1420810|emb|CAA99706.1| (Z75283) ORF YOR375c
[Saccharomyces cerevisiae]
Length = 454
Score = 170 bits (427), Expect = 2e-41
Identities = 139/454 (30%), Positives = 210/454 (45%), Gaps = 50/454 (11%)
Query: 4 QDPFEIAVKQLERAAQYMKISE--EALEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQY 61
Q +E V LE + + + E + L + P+RI++ + E D G +V G+RVQY
Sbjct: 7 QQAYEEVVSSLEDSTLFEQHPEYRKVLPIVSVPERIIQFRVTWENDKGEQEVAQGYRVQY 66
Query: 62 NWARGPTKGGIRWHPEETLSTVKALAAWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREKE 121
N A+GP KGG+R+HP LS +K L +K ++ L GGGKGG+ VD K S+ E
Sbjct: 67 NSAKGPYKGGLRFHPSVNLSILKFLGFEQIFKNSLTGLDMGGGKGGLCVDLKGRSNNEIR 126
Query: 122 RLARGYIRAIYDVISPYEDIPAPDVYTNPQIMAWMMDEYETIARRKTPAFGIITGKPLSI 181
R+ ++R + I D+PA D+ + + ++ Y + K G++TGK L+
Sbjct: 127 RICYAFMRELSRHIGQDTDVPAGDIGVGGREIGYLFGAYRSY---KNSWEGVLTGKGLNW 183
Query: 182 GGSLGRNEATARGASYTIREAAKVL--GWDDLKGKTIAIQGYGNAGYYLAKIMSEDYGMK 239
GGSL R EAT G Y + G + +GK + I G GN Y A + E G
Sbjct: 184 GGSLIRPEATGYGLVYYTQAMIDYATNGKESFEGKRVTISGSGNVAQYAALKVIE-LGGT 242
Query: 240 VVAVSDSKGGIYNPDGLNADEVLKWKREHGSVK-DFPGATNITNEELLELE--------- 289
VV++SDSKG I + G+ +++V + S K +F I NE E
Sbjct: 243 VVSLSDSKGCIISETGITSEQV----ADISSAKVNFKSLEQIVNEYSTFSENKVQYIAGA 298
Query: 290 --------VDVLAPAAIEEVITKKNADNIKA---KIVAEVANGPVTPEADEILFE----- 333
VD+ P A + ++ + A + A K +AE +N TPEA + FE
Sbjct: 299 RPWTHVQKVDIALPCATQNEVSGEEAKALVAQGVKFIAEGSNMGSTPEAIAV-FETARST 357
Query: 334 -----KGILQIPDFLCNAGGVTVSYFEWVQNITGYYWTLEEVREKLDKKMTKAFYDVYNT 388
+ + P N GGV VS E QN WT E V ++L + M F + +
Sbjct: 358 ATGPSEAVWYGPPKAANLGGVAVSGLEMAQNSQRITWTSERVDQELKRIMINCFNECIDY 417
Query: 389 AKEKN------IHMRDAAYVVAVQRVYQAMLDRG 416
AK+ + A + + +V AM D+G
Sbjct: 418 AKKYTKDGKVLPSLVKGANIASFIKVSDAMFDQG 451
>gb|AAD11789.1| (AF098675) glutamate dehydrogenase [Plasmodium falciparum]
Length = 442
Score = 169 bits (424), Expect = 5e-41
Identities = 122/403 (30%), Positives = 192/403 (47%), Gaps = 19/403 (4%)
Query: 28 LEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQYNWARGPTKGGIRWHPEETLSTVKALA 87
+E L P+R ++ + D+G + FRVQYN A GP KGG+R+HP LS VK L
Sbjct: 43 IETLSEPERAIQFRVCWLDDNGVQRKNRCFRVQYNSALGPYKGGLRFHPSVNLSIVKFLG 102
Query: 88 AWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREKERLARGYIRAIYDVISPYEDIPAPDVY 147
+K ++ L GGGKGG DPK SD E + + ++ +Y I P D+PA D+
Sbjct: 103 FEQIFKNSLTGLSMGGGKGGSDFDPKGKSDNEILKFCQAFMNELYRHIGPCTDVPAGDIG 162
Query: 148 TNPQIMAWMMDEYETIARRKTPAFGIITGKPLSIGGSLGRNEATARGASYTIREAAKVLG 207
+ + ++ +Y+ I G +TGK + GGS R EAT G Y + E K L
Sbjct: 163 VGGRQIGYLYGQYKKIVNSFN---GTLTGKNVKWGGSNLRVEATGYGLVYFVLEVLKSLN 219
Query: 208 WDDLKGKTIAIQGYGNAGYYLAKIMSEDYGMKVVAVSDSKGGIYNPDGL---NADEVLKW 264
++ +T + G GN Y + + +KV+ +SDS G +Y P+G N + ++
Sbjct: 220 -IPVEKQTAVVSGSGNVALYCVQKLLH-LNVKVLTLSDSNGYVYEPNGFTHENLEFLIDL 277
Query: 265 KRE-HGSVKDF----PGATNITNEELLELEVDVLAPAAIEEVITKKNADNIKAK---IVA 316
K E G +K++ A NE+ + + P A + I ++A ++ +V
Sbjct: 278 KEEKKGRIKEYLNHSSTAKYFPNEKPWGVPCTLAFPCATQNEINLEDAKLLRKNGCILVG 337
Query: 317 EVANGPVTPEADEILFEKGILQIPDFLCNAGGVTVSYFEWVQNITGYYWTLEEVREKLDK 376
E AN P T +A + I+ P NAGGV +S E QN +WT E V EKL +
Sbjct: 338 EGANMPSTVDAINLFKSNNIIYCPSKAANAGGVAISGLEMSQNFQFSHWTRETVDEKLKE 397
Query: 377 KMTKAFYDVYNTA---KEKNIHMRDAAYVVAVQRVYQAMLDRG 416
M F A + ++ A + +V ++ +++G
Sbjct: 398 IMRNIFIACSENALKYTKNKYDLQAGANIAGFLKVAESYIEQG 440
>emb|CAA73390.1| (Y12927) glutamate dehydrogenase (NADP+) [Plasmodium falciparum]
Length = 470
Score = 169 bits (423), Expect = 7e-41
Identities = 122/403 (30%), Positives = 192/403 (47%), Gaps = 19/403 (4%)
Query: 28 LEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQYNWARGPTKGGIRWHPEETLSTVKALA 87
+E L P+R ++ + D+G + FRVQYN A GP KGG+R+HP LS VK L
Sbjct: 71 IETLSEPERAIQFRVCWLDDNGVQRKNRCFRVQYNSALGPYKGGLRFHPSVNLSIVKFLG 130
Query: 88 AWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREKERLARGYIRAIYDVISPYEDIPAPDVY 147
+K ++ L GGGKGG DPK SD E + + ++ +Y I P D+PA D+
Sbjct: 131 FEQIFKNSLTGLSMGGGKGGSDFDPKGKSDNEILKFCQAFMNELYRHIGPCTDVPAGDIG 190
Query: 148 TNPQIMAWMMDEYETIARRKTPAFGIITGKPLSIGGSLGRNEATARGASYTIREAAKVLG 207
+ + ++ +Y+ I G +TGK + GGS R EAT G Y + E K L
Sbjct: 191 VGGREIGYLYGQYKKIVNSFN---GTLTGKNVKWGGSNLRVEATGYGLVYFVLEVLKSLN 247
Query: 208 WDDLKGKTIAIQGYGNAGYYLAKIMSEDYGMKVVAVSDSKGGIYNPDGL---NADEVLKW 264
++ +T + G GN Y + + +KV+ +SDS G +Y P+G N + ++
Sbjct: 248 -IPVEKQTAVVSGSGNVALYCVQKLLH-LNVKVLTLSDSNGYVYEPNGFTHENLEFLIDL 305
Query: 265 KRE-HGSVKDF----PGATNITNEELLELEVDVLAPAAIEEVITKKNADNIKAK---IVA 316
K E G +K++ A NE+ + + P A + I ++A ++ +V
Sbjct: 306 KEEKKGRIKEYLNHSSTAKYFPNEKPWGVPCTLAFPCATQNEINLEDAKLLQKNGCILVG 365
Query: 317 EVANGPVTPEADEILFEKGILQIPDFLCNAGGVTVSYFEWVQNITGYYWTLEEVREKLDK 376
E AN P T +A + I+ P NAGGV +S E QN +WT E V EKL +
Sbjct: 366 EGANMPSTVDAINLFKSNNIIYCPSKAANAGGVAISGLEMSQNFQFSHWTRETVDEKLKE 425
Query: 377 KMTKAFYDVYNTA---KEKNIHMRDAAYVVAVQRVYQAMLDRG 416
M F A + ++ A + +V ++ +++G
Sbjct: 426 IMRNIFIACSENALKYTKNKYDLQAGANIAGFLKVAESYIEQG 468
>gb|AAB03898.1| (M11297) glutamate dehydrogenase [Saccharomyces cerevisiae]
Length = 454
Score = 168 bits (422), Expect = 9e-41
Identities = 135/450 (30%), Positives = 210/450 (46%), Gaps = 42/450 (9%)
Query: 4 QDPFEIAVKQLERAAQYMKISE--EALEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQY 61
Q +E V LE + + + E + L + P+RI++ + E D G +V G+RVQY
Sbjct: 7 QQAYEEVVSSLEDSTLFEQHPEYRKVLPIVSVPERIIQFRVTWENDKGEQEVAQGYRVQY 66
Query: 62 NWARGPTKGGIRWHPEETLSTVKALAAWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREKE 121
N A+GP KGG+R+HP LS +K L +K ++ L GGGKGG+ VD K S+ E
Sbjct: 67 NSAKGPYKGGLRFHPSGNLSILKFLGFEQIFKNSLTGLDMGGGKGGLCVDLKGRSNNEIR 126
Query: 122 RLARGYIRAIYDVISPYEDIPAPDVYTNPQIMAWMMDEYETIARRKTPAFGIITGKPLSI 181
R+ ++R + I D+PA D+ + + ++ Y + K G++TGK L+
Sbjct: 127 RICYAFMRELSRHIGQDTDVPAGDIGVGGREIGYLFGAYRSY---KNSWEGVLTGKGLNW 183
Query: 182 GGSLGRNEATARGASYTIREAAKVL--GWDDLKGKTIAIQGYGNAGYYLAKIMSEDYGMK 239
GGSL R EAT G Y + G + +GK + I G GN Y A + E G
Sbjct: 184 GGSLIRPEATGYGLLYYTQAMIDYATNGKESFEGKRVTISGSGNVAQYAALKVIE-LGGT 242
Query: 240 VVAVSDSKGGIYNPDGLNADEVL---KWKREHGSVKDFPGATNITNEELLEL-------- 288
VV++SDSKG I G+ +++V K S++ + +E ++
Sbjct: 243 VVSLSDSKGCIILETGITSEQVAVISSAKVNFKSLEQIVNEYSTFSENKVQYIAGARPWT 302
Query: 289 ---EVDVLAPAAIEEVITKKNADNIKA---KIVAEVANGPVTPEADEILFE--------- 333
+VD+ P A + ++ + A + A K +AE +N TPEA + FE
Sbjct: 303 HVQKVDIALPCATQNEVSGEEAKALVAQGVKFIAEGSNMGSTPEAIAV-FETARSTATGP 361
Query: 334 -KGILQIPDFLCNAGGVTVSYFEWVQNITGYYWTLEEVREKLDKKMTKAFYDVYNTAKEK 392
+ + P N GGV VS E QN WT E V ++L + M F + + AK+
Sbjct: 362 SEAVWYGPPKAANLGGVAVSGLEMAQNSQRITWTSERVDQELKRIMINCFNECIDYAKKY 421
Query: 393 N------IHMRDAAYVVAVQRVYQAMLDRG 416
+ A + + +V AM D+G
Sbjct: 422 TKDGKVLPSLVKGANIASFIKVSDAMFDQG 451
>sp|P54388|DHE4_LACBI NADP-SPECIFIC GLUTAMATE DEHYDROGENASE (NADP-GDH)
>gi|1101027|gb|AAA82936.1| (U31369) NADP-glutamate
dehydrogenase [Laccaria bicolor]
Length = 450
Score = 168 bits (420), Expect = 2e-40
Identities = 128/378 (33%), Positives = 187/378 (48%), Gaps = 26/378 (6%)
Query: 26 EALEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQYNWARGPTKGGIRWHPEETLSTVKA 85
+ALE + P+R+++ + E D G +V GFRVQYN A GP KGG+R HP LS +K
Sbjct: 32 KALEIVPIPERVLQFRVIWEDDQGKAQVNRGFRVQYNSALGPYKGGLRLHPSVNLSILKF 91
Query: 86 LAAWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREKERLARGYIRAIYDVISPYEDIPAPD 145
L T+K A+ L GGGKGG DPK SD E R ++ ++ I D+PA D
Sbjct: 92 LGFEQTFKNALTGLSMGGGKGGSDFDPKGKSDGEIRRFCTSFMSELFRHIGQDTDVPAGD 151
Query: 146 VYTNPQIMAWMMDEYETIARRKTPAFGIITGKPLSIGGSLGRNEATARGASYTIRE--AA 203
+ T + + ++ Y+ + + G++TGK L+ GGS R EAT G Y + A
Sbjct: 152 IGTGAREIGYLFGAYKKL---QNEFVGMLTGKGLAWGGSFIRPEATGYGLIYYVEHMIAK 208
Query: 204 KVLGWDDLKGKT-IAIQGYGNAGYYLAKIMSEDYGMKVVAVSDSKGGIYNPDGLNAD--- 259
+ K +T +AI G GN G + A + E G V+++SDSKG + G +
Sbjct: 209 AAPEYSLSKPETLVAISGSGNVGQFTALKVIE-LGATVLSLSDSKGSLIAEKGYTKEFIK 267
Query: 260 EVLKWKREHGSVKDFPGATNITNE------ELLELEVDVLAPAAIEEVITKKNA-DNIKA 312
E+ + K + G+++ T LL + V V P A + ++K A D IKA
Sbjct: 268 EIGQLKLKGGALESLAQREGYTYHAGKRPWSLLPV-VHVALPGATQNEVSKTEAEDLIKA 326
Query: 313 --KIVAEVANGPVTPEADEILFEK------GILQIPDFLCNAGGVTVSYFEWVQNITGYY 364
+IVAE +N T +A + E G+ P N GGV VS E QN
Sbjct: 327 GVRIVAEGSNMGCTEDAIAVFEESRKAGAGGVWYAPGKASNCGGVAVSGLEMAQNSQRLA 386
Query: 365 WTLEEVREKLDKKMTKAF 382
WT ++V +KL K M + +
Sbjct: 387 WTTDQVDQKLKKIMAECY 404
>gb|AAG12331.1|AF269241_1 (AF269241) glutamate dehydrogenase [Plasmodium falciparum]
Length = 442
Score = 168 bits (420), Expect = 2e-40
Identities = 122/403 (30%), Positives = 192/403 (47%), Gaps = 19/403 (4%)
Query: 28 LEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQYNWARGPTKGGIRWHPEETLSTVKALA 87
+E L P+R ++ + D+G + FRVQYN A GP KGG+R+HP LS VK L
Sbjct: 43 IETLSEPERGIQFRVCWLDDNGVQRKNRCFRVQYNSALGPYKGGLRFHPSVNLSIVKFLG 102
Query: 88 AWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREKERLARGYIRAIYDVISPYEDIPAPDVY 147
+K ++ L GGGKGG DPK SD E + + ++ +Y I P D+PA D+
Sbjct: 103 FEQIFKNSLTGLSMGGGKGGSDFDPKGKSDNEILKFCQAFMNELYRHIGPCTDVPAGDIG 162
Query: 148 TNPQIMAWMMDEYETIARRKTPAFGIITGKPLSIGGSLGRNEATARGASYTIREAAKVLG 207
+ + ++ +Y+ I G +TGK + GGS R EAT G Y + E K L
Sbjct: 163 VGGREVGYLYGQYKKIVNSFN---GTLTGKNVKWGGSNLRVEATGYGLVYFVLEVLKSLN 219
Query: 208 WDDLKGKTIAIQGYGNAGYYLAKIMSEDYGMKVVAVSDSKGGIYNPDGL---NADEVLKW 264
++ +T + G GN Y + + +KV+ +SDS G +Y P+G N + ++
Sbjct: 220 -IPVEKQTAVVSGSGNVALYCVQKLLH-LNVKVLTLSDSNGYVYEPNGFTHENLEFLIDL 277
Query: 265 KRE-HGSVKDF----PGATNITNEELLELEVDVLAPAAIEEVITKKNADNIKAK---IVA 316
K E G +K++ A NE+ + + P A + I ++A ++ +V
Sbjct: 278 KEEKKGRIKEYLNHSSTAKYFPNEKPWGVPCTLAFPCATQNEINLEDAKLLQKNGCILVG 337
Query: 317 EVANGPVTPEADEILFEKGILQIPDFLCNAGGVTVSYFEWVQNITGYYWTLEEVREKLDK 376
E AN P T +A + I+ P NAGGV +S E QN +WT E V EKL +
Sbjct: 338 EGANMPSTVDAINLFKSNNIIYCPSKAANAGGVAISGLEMSQNFQFSHWTRETVDEKLKE 397
Query: 377 KMTKAFYDVYNTA---KEKNIHMRDAAYVVAVQRVYQAMLDRG 416
M F A + ++ A + +V ++ +++G
Sbjct: 398 IMRNIFIACSENALKYTKNKYDLQAGANIAGFLKVAESYIEQG 440
>sp|P18819|DHE4_EMENI NADP-SPECIFIC GLUTAMATE DEHYDROGENASE (NADP-GDH)
Length = 459
Score = 166 bits (416), Expect = 4e-40
Identities = 139/455 (30%), Positives = 211/455 (45%), Gaps = 53/455 (11%)
Query: 7 FEIAVKQLERAAQYMKISEE------ALEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQ 60
FE A K+L + + E+ AL+ + P+R+++ + E D G V++ G+RVQ
Sbjct: 10 FEQAYKELASTLENSTLFEQHPEYRRALQVVSVPERVIQFRVVWENDKGEVQINRGYRVQ 69
Query: 61 YNWARGPTKGGIRWHPEETLSTVKALAAWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREK 120
+N A GP KGG+R+HP LS +K L +K A+ L GGGKGG DPK SD E
Sbjct: 70 FNSALGPYKGGLRFHPSVNLSILKFLGFEQIFKNALTGLNMGGGKGGSDFDPKGKSDSEI 129
Query: 121 ERLARGYIRAIYDVISPYEDIPAPDVYTNPQIMAWMMDEYETIARRKTPAFGIITGKPLS 180
R ++ + I D+PA D+ + + ++ +Y I + G++TGK S
Sbjct: 130 RRFCTAFMTELCKHIGADTDVPAGDIGVTGREVGFLFGQYRRIRNQWE---GVLTGKGGS 186
Query: 181 IGGSLGRNEATARGASYTIREAAKVL--GWDDLKGKTIAIQGYGNAGYYLAKIMSEDYGM 238
GGSL R EAT G Y ++ K + G + GK +AI G GN Y A + E G
Sbjct: 187 WGGSLIRPEATGYGVVYYVQHMIKHVTGGKESFAGKRVAISGSGNVAQYAALKVIE-LGG 245
Query: 239 KVVAVSDSKGGI--------YNPDGLNADEVLKWKREH-----------GSVKDFPGATN 279
VV++SDSKG + + P+ + LK R+ G P A
Sbjct: 246 SVVSLSDSKGSLIVKDESASFTPEEIALIADLKVARKQLSELATSSAFAGKFTYIPDARP 305
Query: 280 ITNEELLELEVDVLAPAAIEEVITKKNADNI---KAKIVAEVANGPVTPEADEILFE--- 333
TN + + +V P+A + ++ + A+++ + +AE +N T A +I FE
Sbjct: 306 WTN---IPGKFEVALPSATQNEVSGEEAEHLIKSGVRYIAEGSNMGCTQAAIDI-FEAHR 361
Query: 334 -----KGILQIPDFLCNAGGVTVSYFEWVQNITGYYWTLEEVREKLDKKMTKAFYDVYNT 388
I P NAGGV VS E QN WT EEV +L M F + T
Sbjct: 362 NANPGDAIWYAPGKAANAGGVAVSGLEMAQNSARLSWTSEEVDARLKGIMEDCFKNGLET 421
Query: 389 AKE-----KNI--HMRDAAYVVAVQRVYQAMLDRG 416
A++ K + + + + +V +AM D+G
Sbjct: 422 AQKFATPAKGVLPSLVTGSNIAGFTKVAEAMKDQG 456
>pir||S04904 glutamate dehydrogenase (NADP+) (EC 1.4.1.4) - Emericella nidulans
>gi|2348|emb|CAA34252.1| (X16121) NADP linked glutamate
dehydrogenase [Emericella nidulans]
Length = 459
Score = 166 bits (415), Expect = 6e-40
Identities = 139/455 (30%), Positives = 211/455 (45%), Gaps = 53/455 (11%)
Query: 7 FEIAVKQLERAAQYMKISEE------ALEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQ 60
FE A K+L + + E+ AL+ + P+R+++ + E D G V++ G+RVQ
Sbjct: 10 FEQAYKELASTLENSTLFEQHPEYRRALQVVSVPERVIQFRVVWENDKGEVQINRGYRVQ 69
Query: 61 YNWARGPTKGGIRWHPEETLSTVKALAAWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREK 120
+N A GP KGG+R+HP LS +K L +K A+ L GGGKGG DPK SD E
Sbjct: 70 FNSALGPYKGGLRFHPSVNLSILKFLGFEQIFKNALTGLNMGGGKGGSDFDPKGKSDSEI 129
Query: 121 ERLARGYIRAIYDVISPYEDIPAPDVYTNPQIMAWMMDEYETIARRKTPAFGIITGKPLS 180
R ++ + I D+PA D+ + + ++ +Y I + G++TGK S
Sbjct: 130 RRFCTAFMTELCKHIGADTDLPAGDIGVTGREVGFLFGQYRRIRNQWE---GVLTGKGGS 186
Query: 181 IGGSLGRNEATARGASYTIREAAKVL--GWDDLKGKTIAIQGYGNAGYYLAKIMSEDYGM 238
GGSL R EAT G Y ++ K + G + GK +AI G GN Y A + E G
Sbjct: 187 WGGSLIRPEATGYGVVYYVQHMIKHVTGGKESFAGKRVAISGSGNVAQYAALKVIE-LGG 245
Query: 239 KVVAVSDSKGGI--------YNPDGLNADEVLKWKREH-----------GSVKDFPGATN 279
VV++SDSKG + + P+ + LK R+ G P A
Sbjct: 246 SVVSLSDSKGSLIVKDESASFTPEEIALIADLKVARKQLSELATSSAFAGKFTYIPDARP 305
Query: 280 ITNEELLELEVDVLAPAAIEEVITKKNADNI---KAKIVAEVANGPVTPEADEILFE--- 333
TN + + +V P+A + ++ + A+++ + +AE +N T A +I FE
Sbjct: 306 WTN---IPGKFEVALPSATQNEVSGEEAEHLIKSGVRYIAEGSNMGCTQAAIDI-FEAHR 361
Query: 334 -----KGILQIPDFLCNAGGVTVSYFEWVQNITGYYWTLEEVREKLDKKMTKAFYDVYNT 388
I P NAGGV VS E QN WT EEV +L M F + T
Sbjct: 362 NANPGDAIWYAPGKAANAGGVAVSGLEMAQNSARLSWTSEEVDARLKGIMEDCFKNGLET 421
Query: 389 AKE-----KNI--HMRDAAYVVAVQRVYQAMLDRG 416
A++ K + + + + +V +AM D+G
Sbjct: 422 AQKFATPAKGVLPSLVTGSNIAGFTKVAEAMKDQG 456
>sp|Q9ZKD8|DHE4_HELPJ NADP-SPECIFIC GLUTAMATE DEHYDROGENASE (NADP-GDH)
>gi|7431761|pir||F71862 glutamate dehydrogenase -
Helicobacter pylori (strain J99)
>gi|4155581|gb|AAD06574.1| (AE001528) GLUTAMATE
DEHYDROGENASE [Helicobacter pylori J99]
Length = 448
Score = 166 bits (415), Expect = 6e-40
Identities = 130/409 (31%), Positives = 200/409 (48%), Gaps = 28/409 (6%)
Query: 28 LEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQYNWARGPTKGGIRWHPEETLSTVKALA 87
LE L P+R + + D+ ++V G RV++N A GP KGG+R+HP S +K L
Sbjct: 47 LERLIEPEREIFFRVCWLDDNHQIQVNRGCRVEFNSAIGPYKGGLRFHPSVNESVIKFLG 106
Query: 88 AWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREKERLARGYIRAIYDVISPYEDIPAPDVY 147
K ++ L GG KGG DPK+ S+ E R + ++ +Y I D+PA D+
Sbjct: 107 FEQVLKNSLTTLAMGGAKGGSDFDPKEKSEHEIMRFCQAFMNELYRHIGATTDVPAGDIG 166
Query: 148 TNPQIMAWMMDEYETIARRKTPAFGIITGKPLSIGGSLGRNEATARGASYTIREAAKVLG 207
+ + ++ +Y+ + R G++TGK L+ GGSL R EAT G Y E +
Sbjct: 167 VGEREIGYLFGQYKKLVNRFE---GVLTGKGLTYGGSLCRKEATGYGCVYFAEEMLQERN 223
Query: 208 WDDLKGKTIAIQGYGNAGYYLAKIMSEDYGMKVVAVSDSKGGIYNPDGLNADEVLKWKRE 267
L+GK ++ G GN Y + + + G K V SDS G IY+ DG++ E+LK +E
Sbjct: 224 -SSLEGKVCSVSGSGNVAIYTIEKLLQ-IGAKPVTASDSNGMIYDKDGIDL-ELLKEIKE 280
Query: 268 --HGSVKDFPGATNITNEELLELE-----------VDVLA--PAAIEEVITKKNADNIKA 312
G +K++ A T+ + E V A P+A E ++ +A + +
Sbjct: 281 ARRGRIKEY--ALEKTSAKYTPTENYPKGGNAIWHVPCFAAFPSATENELSVLDAKTLLS 338
Query: 313 ---KIVAEVANGPVTPEADEILFEKGILQIPDFLCNAGGVTVSYFEWVQNITGYYWTLEE 369
K VAE AN P + EA E+ + I NAGGV+VS E QN + + W+ E
Sbjct: 339 NGCKCVAEGANMPSSNEAIELFLQAKISYGIGKAANAGGVSVSGLEMAQNASMHPWSFEV 398
Query: 370 VREKLDKKMTKAFYDVYNTAKE--KNIHMRDAAYVVAVQRVYQAMLDRG 416
V KL M + + +V TAKE + A + ++V AM+ +G
Sbjct: 399 VDAKLHHIMKEIYKNVSQTAKEFKDPTNFVLGANIAGFRKVASAMIAQG 447
>sp|P54387|DHE4_AGABI NADP-SPECIFIC GLUTAMATE DEHYDROGENASE (NADP-GDH)
>gi|2133369|pir||S63608 glutamate dehydrogenase (NADP+)
(EC 1.4.1.4) - cultivated mushroom
>gi|1051292|emb|CAA58312.1| (X83393) NADP-dependent
glutamate dehydrogenase (NADP+) [Agaricus bisporus]
Length = 457
Score = 163 bits (408), Expect = 4e-39
Identities = 130/407 (31%), Positives = 197/407 (47%), Gaps = 32/407 (7%)
Query: 7 FEIAVKQLERAAQYMKIS----EEALEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQYN 62
FE A+ +LE + Q + ++ALE ++ P+R+++ + E D G +V GFRVQYN
Sbjct: 9 FEQALHELETSLQPFLTTNPQYKKALEIIQVPERVLQFRVTWEDDQGKPQVNRGFRVQYN 68
Query: 63 WARGPTKGGIRWHPEETLSTVKALAAWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREKER 122
A GP KGG+R HP LS +K L T+K A+ L GGGKGG DPK SD E R
Sbjct: 69 SALGPYKGGLRLHPTVNLSILKFLGFEQTFKNALTGLSMGGGKGGSDFDPKGKSDNEIRR 128
Query: 123 LARGYIRAIYDVISPYEDIPAPDVYTNPQIMAWMMDEYETIARRKTPAFGIITGKPLSIG 182
++ ++ I D+PA D+ T + + ++ Y R K G++TGK ++ G
Sbjct: 129 FCVAFMSELFRHIGQDTDVPAGDIGTGAREIGFLFGAYR---RLKNEFTGMLTGKGINWG 185
Query: 183 GSLGRNEATARGASYTIREAAKVLGWD---DLKGKTIAIQGYGNAGYYLAKIMSEDYGMK 239
GS R EAT G Y + + D +AI G GN + A + E G
Sbjct: 186 GSFIRPEATGYGLIYYVEHMIAHACPEYSLDRPSTLVAISGSGNVSQFTALKVIE-LGAT 244
Query: 240 VVAVSDSKGGIYNPDGLN---ADEVLKWKREHGSVKDF-----PGATNITNEELLEL--E 289
V+++SDSKG + + G +++ + K + G+++ G T + L +
Sbjct: 245 VLSLSDSKGSLISEKGYTKEAIEKIAELKLKGGALEAIVDDLGAGYTYHAGKRPWTLLPQ 304
Query: 290 VDVLAPAAIEEVITKKNADN-IKA--KIVAEVANGPVTPEADEILFEK-------GILQI 339
V + P A + ++++ A+ +KA +IVAE +N T EA I FE G+
Sbjct: 305 VHIALPGATQNEVSQEEAEALVKAGTRIVAEGSNMGCTEEAIAI-FENSRRASRAGVWYA 363
Query: 340 PDFLCNAGGVTVSYFEWVQNITGYYWTLEEVREKLDKKMTKAFYDVY 386
P N GGV VS E QN W+ +EV KL M + + Y
Sbjct: 364 PGKASNCGGVAVSGLEMAQNSQRLAWSTQEVDAKLKSIMAECYQICY 410
>sp|P55990|DHE4_HELPY NADP-SPECIFIC GLUTAMATE DEHYDROGENASE (NADP-GDH)
>gi|7431763|pir||D64567 glutamate dehydrogenase -
Helicobacter pylori (strain 26695)
>gi|2313483|gb|AAD07448.1| (AE000554) glutamate
dehydrogenase (gdhA) [Helicobacter pylori 26695]
Length = 448
Score = 162 bits (405), Expect = 9e-39
Identities = 126/407 (30%), Positives = 196/407 (47%), Gaps = 24/407 (5%)
Query: 28 LEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQYNWARGPTKGGIRWHPEETLSTVKALA 87
LE L P+R + + D+ ++V G RV++N A GP KGG+R+HP S +K L
Sbjct: 47 LERLIEPEREIFFRVCWLDDNNQIQVNRGCRVEFNSAIGPYKGGLRFHPSVNESVIKFLG 106
Query: 88 AWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREKERLARGYIRAIYDVISPYEDIPAPDVY 147
K ++ L GG KGG DPK S+ E R + ++ +Y I D+PA D+
Sbjct: 107 FEQVLKNSLTTLAMGGAKGGSDFDPKGKSEHEIMRFCQAFMNELYRHIGATTDVPAGDIG 166
Query: 148 TNPQIMAWMMDEYETIARRKTPAFGIITGKPLSIGGSLGRNEATARGASYTIREAAKVLG 207
+ + ++ +Y+ + R G++TGK L+ GGSL R EAT G Y E +
Sbjct: 167 VGEREIGYLFGQYKKLVNRFE---GVLTGKGLTYGGSLCRKEATGYGCVYFAEEMLQERN 223
Query: 208 WDDLKGKTIAIQGYGNAGYYLAKIMSEDYGMKVVAVSDSKGGIYNPDGLNADEVLKWKRE 267
L+GK ++ G GN Y + + + G K V SDS G IY+ DG++ E+LK +E
Sbjct: 224 -SSLEGKVCSVSGSGNVAIYTIEKLLQ-IGAKPVTASDSNGMIYDKDGIDL-ELLKEIKE 280
Query: 268 --HGSVKDF---PGATNITNEE--------LLELEVDVLAPAAIEEVITKKNADNIKA-- 312
G +K++ + T E + + P+A E ++ +A + +
Sbjct: 281 VRRGRIKEYALEKKSAEYTPTENYPKGGNAVWHVPCFAAFPSATENELSVLDAKTLLSNG 340
Query: 313 -KIVAEVANGPVTPEADEILFEKGILQIPDFLCNAGGVTVSYFEWVQNITGYYWTLEEVR 371
K VAE AN P + EA + + I NAGGV+VS E QN + + W+ E V
Sbjct: 341 CKCVAEGANMPSSNEAIGLFLQAKISYGIGKAANAGGVSVSGLEMAQNASMHPWSFEVVD 400
Query: 372 EKLDKKMTKAFYDVYNTAKE--KNIHMRDAAYVVAVQRVYQAMLDRG 416
KL M + + +V TAKE + A + ++V AM+ +G
Sbjct: 401 AKLHHIMKEIYKNVSQTAKEFKDPTNFVLGANIAGFRKVASAMIAQG 447
>gb|AAG29684.1|AC025294_6 (AC025294) NADP-specific glutatamate dehydrogenase, putative
[Arabidopsis thaliana]
Length = 624
Score = 150 bits (375), Expect = 3e-35
Identities = 125/447 (27%), Positives = 203/447 (44%), Gaps = 41/447 (9%)
Query: 2 VEQDPFEI--------AVKQLERA----AQYMKISEEALEFLKRPQRIVEVTIPVEMDDG 49
+++DP EI +V LER + Y+ I E LE P+R++ +P D G
Sbjct: 189 LKRDPNEIEFVQSVQESVHALERVIAKNSHYVNIMERLLE----PERMIVFRVPWIDDRG 244
Query: 50 SVKVFTGFRVQYNWARGPTKGGIRWHPEETLSTVKALAAWMTWKTAVMDLPYGGGKGGII 109
V GFRVQ+N A GP +GGIR+HP LS K L T K A+ GG GG
Sbjct: 245 ETHVNRGFRVQFNQALGPCRGGIRFHPSMNLSIAKFLGFQQTLKNALSPYKLGGASGGSD 304
Query: 110 VDPKKLSDREKERLARGYIRAIYDVISPYEDIPAPDVYTNPQIMAWMMDEYETIARRKTP 169
DPK SD E R + ++ +Y + P +D+P+ +V + M ++ +Y +A +
Sbjct: 305 FDPKGKSDNEIMRFCQSFMNEMYRYMGPDKDLPSEEVGVGTREMGYLFGQYRRLAGQFQG 364
Query: 170 AFGIITGKPLSIGGSLGRNEATARGASYTIREAAKVLGWDDLKGKTIAIQGYGN-AGYYL 228
+F TG + S R EA+ G Y R + ++KG + G G A + +
Sbjct: 365 SF---TGPRIYWAASSLRTEASGYGVVYFARLILADMN-KEIKGLRCVVSGCGKIAMHVV 420
Query: 229 AKIMSEDYGMKVVAVSDSKGGIYNPDGLNADEVL---KWKREHGSVKDFPGATNITNEEL 285
K+++ G V VSDSKG + + DG + ++ K + S++D+ T +
Sbjct: 421 EKLIA--CGAHPVTVSDSKGYLVDDDGFDYMKLAFLRDIKSQQRSLRDY-SKTYARAKYF 477
Query: 286 LELE-----VDVLAPAAIEEVITKKNADNI---KAKIVAEVANGPVTPEADEILFEKGIL 337
EL+ DV P A + + + +A N+ +++ E +N P T EA ++ + +L
Sbjct: 478 DELKPWNERCDVAFPCASQNEVDQADAINLVNAGCRLLVEGSNMPCTAEAVDVFRKANVL 537
Query: 338 QIPDFLCNAGGVTVSYFEWVQNITGYYWTLEEVREKLDKKMTKAFYDVYNTA------KE 391
P AGGV E ++ W+ E+ +L + + + + A KE
Sbjct: 538 IAPAIAAGAGGVAAGEIEVLRESNSMQWSAEDFESRLQEALKQTYEKALKAANDFGYQKE 597
Query: 392 KNIHMRDAAYVVAVQRVYQAMLDRGWV 418
+ A + A + QAM D+G V
Sbjct: 598 SPEALLHGATIAAFLNIAQAMTDQGCV 624
>dbj|BAA83910.1| (AB024549) GDHA [Bacillus halodurans]
Length = 300
Score = 120 bits (298), Expect = 3e-26
Identities = 94/303 (31%), Positives = 143/303 (47%), Gaps = 15/303 (4%)
Query: 127 YIRAIYDVISPYEDIPAPDVYTNPQIMAWMMDEYETIARRKTPAFGIITGKPLSIGGSLG 186
++ + + I P D+PA D+ + + +M +Y+ + R G++TGK + GGSL
Sbjct: 2 FMSELSNYIGPDIDVPAGDIGVGAKEIGYMFGQYKKM--RGGFEAGVLTGKGIGYGGSLA 59
Query: 187 RNEATARGASYTIREAAKVLGWDDLKGKTIAIQGYGNAGYYLAKIMSEDYGMKVVAVSDS 246
R EAT G Y + E K G+ G T+ + G GN Y A + G KVVA SDS
Sbjct: 60 RKEATGYGTVYFVEEMIKDHGFS-FAGSTVVVSGSGNVSIY-AMEKAMQLGAKVVACSDS 117
Query: 247 KGGIYNPDGLNADEV-----LKWKREHGSVKDFPGATNITN-EELLELEVDVLAPAAIEE 300
G +Y+ +G++ V ++ KR V + P A + + + D+ P A +
Sbjct: 118 GGYVYDKNGIDLQTVKRLKEVERKRISEYVNEHPHAHYVQGCSGIWSVPCDIALPCATQN 177
Query: 301 VITKKNADNIKA---KIVAEVANGPVTPEADEILFEKGILQIPDFLCNAGGVTVSYFEWV 357
+ + A + A K V E AN P T +A E G+L P NAGGV+VS E
Sbjct: 178 ELDEAAATMLIANGVKAVGEGANMPSTLQAVHTFQEHGVLFAPAKAANAGGVSVSALEMA 237
Query: 358 QNITGYYWTLEEVREKLDKKMTKAFYDVYNTAK--EKNIHMRDAAYVVAVQRVYQAMLDR 415
QN T WT EEV KL + M + + A+ E + ++ A + +V AM+
Sbjct: 238 QNSTRLAWTFEEVDAKLYEIMKNIYRESIKAAELYEASGNLVVGANIAGFVKVADAMISH 297
Query: 416 GWV 418
G V
Sbjct: 298 GVV 300
>sp|P23307|DHPH_BACSH PHENYLALANINE DEHYDROGENASE (PHEDH) >gi|2126840|pir||I39939
phenylalanine dehydrogenase (EC 1.4.1.-) - Bacillus
sphaericus >gi|529017|gb|AAA22646.1| (M26661)
phenylalanine dehydrogenase [Bacillus sphaericus]
Length = 381
Score = 106 bits (261), Expect = 7e-22
Identities = 97/344 (28%), Positives = 159/344 (46%), Gaps = 45/344 (13%)
Query: 12 KQLERAAQYMKISEEALEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQYNWARGPTKGG 71
KQLE++++ +E+ + + ++IV PV + + ++ GP GG
Sbjct: 3 KQLEKSSKIG--NEDVFQKIANHEQIVFCNDPVSGLQAIIAI-------HDTTLGPALGG 53
Query: 72 IRWHP----EETLSTVKALAAWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREKERLARGY 127
R +P +E L V L+ MT+K A D+ +GGGK II DP+K D+
Sbjct: 54 TRMYPYKNVDEALEDVLRLSEGMTYKCAAADIDFGGGKAVIIGDPEK--DKSP------- 104
Query: 128 IRAIYDVISPYEDIPAPDVYTNPQIMAWMMDEYETIARRKTPAFGIITGKPLSIGGSLGR 187
A++ + + YT M MD++ A+++T I G P GGS
Sbjct: 105 --ALFRAFGQFVESLNGRFYTGTD-MGTTMDDF-VHAQKET---NFINGIPEQYGGSGDS 157
Query: 188 NEATARGASYTIREAAKVL-GWDDLKGKTIAIQGYGNAGYYLAKIMSEDYGMKVVAVSDS 246
+ TA+G Y ++ + L G D L GKT AIQG G GY +A+ + + + V+D
Sbjct: 158 SIPTAQGVIYALKATNQYLFGSDSLSGKTYAIQGLGKVGYKVAEQLLK--AGADLFVTDI 215
Query: 247 KGGIYNPDGLNADEVLKWKREHGSVKDFPGATNITNEELLELEVDVLAPAAIEEVITKKN 306
+ N ++E+ GSV T + ++++ ++ D+ P A+ +I K
Sbjct: 216 HENVLNSIKQKSEEL------GGSV------TIVKSDDIYSVQADIFVPCAMGGIINDKT 263
Query: 307 ADNIKAKIVAEVANGPVTP-EADEILFEKGILQIPDFLCNAGGV 349
+K K V AN + +L EKGIL PD++ NAGG+
Sbjct: 264 IPKLKVKAVVGSANNQLKDLRHANVLNEKGILYAPDYIVNAGGL 307
>emb|CAB66900.1| (AJ270942) glutamate deshydrogenase [Klebsiella pneumoniae]
Length = 304
Score = 104 bits (256), Expect = 3e-21
Identities = 87/311 (27%), Positives = 137/311 (43%), Gaps = 26/311 (8%)
Query: 122 RLARGYIRAIYDVISPYEDIPAPDVYTNPQIMAWMMDEYETIARRKTPAFGIITGKPLSI 181
R + + +Y + D+PA D+ + + +M + ++ F TGK LS
Sbjct: 2 RFCQALMTELYRHLGADTDVPAGDIGVGGREVGFMAGMMKKLSNNTACVF---TGKGLSF 58
Query: 182 GGSLGRNEATARGASYTIREAAKVLGWDDLKGKTIAIQGYGN-AGYYLAKIMSEDYGMKV 240
GGSL R EAT G Y K G +G +A+ G GN A Y + K M+ G +V
Sbjct: 59 GGSLIRPEATGYGLVYFTDAMLKRHGLG-FEGMRVAVSGSGNVAQYAIEKAMA--LGARV 115
Query: 241 VAVSDSKGGIYNPDGLNADEVLKW----KREHGSVKDFP---GATNITNEELLELEVDVL 293
+ SDS G + + G +++ + ++ G + D+ G T + ++ + VD+
Sbjct: 116 ITASDSNGTVVDEAGFTTEKLARLCQIKSQQDGRIADYAKEFGLTYLEGQQPWGVSVDIA 175
Query: 294 APAAIEEVITKKNADNIKA---KIVAEVANGPVTPEADEILFEKGILQIPDFLCNAGGVT 350
P A + + A + A K VAE AN P T EA ++ E G+L P NAGGV
Sbjct: 176 LPCATQNELDAPAARILIANGVKAVAEGANMPTTIEATDLFLEAGVLFAPGKAANAGGVA 235
Query: 351 VSYFEWVQNITGYYWTLEEVREKLDKKMTKAFYDVYNT-----AKEKNIHMRDAAYVVAV 405
S E QN W EK+D ++ D++ ++K H A +
Sbjct: 236 TSGLEMAQNAARMGWK----AEKVDLRLHHIMLDIHQACVEYGGEDKQTHYVRGANIAGF 291
Query: 406 QRVYQAMLDRG 416
+V AML +G
Sbjct: 292 VKVADAMLAQG 302
>gb|AAA25070.1| (M30538) glutamate dehydrogenase (gdhA) (EC 1.4.1.4) [Klebsiella
aerogenes]
Length = 160
Score = 84.7 bits (206), Expect = 2e-15
Identities = 48/124 (38%), Positives = 69/124 (54%), Gaps = 2/124 (1%)
Query: 14 LERAAQYMKISEEALEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQYNWARGPTKGGIR 73
LE +Y +++ LE L P+R+++ + D V+V +RVQ+N A GP KGG+R
Sbjct: 39 LEENPRYRQLA--LLERLVEPERVIQFRVVWVDDRNQVQVNRAWRVQFNSAIGPYKGGMR 96
Query: 74 WHPEETLSTVKALAAWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREKERLARGYIRAIYD 133
+HP LS +K L T+K A+ LP GGGKGG DPK SD E R + + +Y
Sbjct: 97 FHPSVNLSILKFLGFEQTFKNALTTLPMGGGKGGSDFDPKGKSDGEVMRFCQALMTELYR 156
Query: 134 VISP 137
+ P
Sbjct: 157 HLGP 160
>gb|AAD21520.1| (AF009232) glutamate dehydrogenase [Klebsiella pneumoniae]
>gi|4511869|gb|AAD21521.1| (AF009233) glutamate
dehydrogenase [Klebsiella pneumoniae subsp. ozaenae]
>gi|4511871|gb|AAD21522.1| (AF009234) glutamate
dehydrogenase [Klebsiella pneumoniae subsp.
rhinoscleromatis] >gi|4511873|gb|AAD21523.1| (AF009235)
glutamate dehydrogenase [Calymmatobacterium
granulomatis]
Length = 125
Score = 80.4 bits (195), Expect = 4e-14
Identities = 46/112 (41%), Positives = 64/112 (57%), Gaps = 2/112 (1%)
Query: 14 LERAAQYMKISEEALEFLKRPQRIVEVTIPVEMDDGSVKVFTGFRVQYNWARGPTKGGIR 73
LE +Y +++ LE L P+R+++ + D V+V +RVQ+N A GP KGG+R
Sbjct: 11 LEENPRYRQLA--LLERLVEPERVIQFRVVWVDDRNQVQVNRAWRVQFNSAIGPYKGGMR 68
Query: 74 WHPEETLSTVKALAAWMTWKTAVMDLPYGGGKGGIIVDPKKLSDREKERLAR 125
+HP LS +K L T+K A+ LP GGGKGG DPK SD E R +
Sbjct: 69 FHPSVNLSILKFLGFEQTFKNALTTLPMGGGKGGSDFDPKGKSDGEVMRFCQ 120
Database: ./suso.pep
Posted date: Jul 6, 2001 5:57 PM
Number of letters in database: 840,471
Number of sequences in database: 2977
Database: /banques/blast2/nr.pep
Posted date: Dec 14, 2000 12:46 PM
Number of letters in database: 188,266,275
Number of sequences in database: 595,510
Lambda K H
0.317 0.135 0.402
Gapped
Lambda K H
0.270 0.0470 0.230
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 166999563
Number of Sequences: 2977
Number of extensions: 7435522
Number of successful extensions: 19608
Number of sequences better than 1.0e-10: 184
Number of HSP's better than 0.0 without gapping: 149
Number of HSP's successfully gapped in prelim test: 35
Number of HSP's that attempted gapping in prelim test: 18856
Number of HSP's gapped (non-prelim): 202
length of query: 420
length of database: 189,106,746
effective HSP length: 56
effective length of query: 364
effective length of database: 155,591,474
effective search space: 56635296536
effective search space used: 56635296536
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 41 (21.6 bits)
S2: 166 (69.1 bits)