BLASTP 2.0.10 [Aug-26-1999]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= PAB0514 (serA-like) DE:phosphoglycerate dehydrogenase (serA),
Nter fragment
(307 letters)
Database: ./suso.pep; /banques/blast2/nr.pep
598,487 sequences; 189,106,746 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
pir||B75120 phosphoglycerate dehydrogenase truncated homolog PAB... 592 e-168
pir||E71011 probable phosphoglycerate dehydrogenase - Pyrococcus... 564 e-160
sp|O27051|SERA_METTH D-3-PHOSPHOGLYCERATE DEHYDROGENASE (PGDH) >... 332 3e-90
sp|Q58424|SERA_METJA D-3-PHOSPHOGLYCERATE DEHYDROGENASE (PGDH) >... 313 2e-84
gi|11498419 phosphoglycerate dehydrogenase (serA) [Archaeoglobus... 309 4e-83
pir||B72257 D-3-phosphoglycerate dehydrogenase - Thermotoga mari... 284 9e-76
gb|AAG20511.1| (AE005123) phosphoglycerate dehydrogenase; SerA1 ... 270 1e-71
pir||A71175 probable dehydrogenase - Pyrococcus horikoshii >gi|3... 270 2e-71
pir||B75057 glycerate dehydrogenase PAB2374 - Pyrococcus abyssi ... 268 6e-71
sp|P73821|SERA_SYNY3 D-3-PHOSPHOGLYCERATE DEHYDROGENASE (PGDH) >... 268 7e-71
pir||E72568 probable D-3-phosphoglycerate dehydrogenase APE1831 ... 257 8e-68
sp|O04130|SERA_ARATH D-3-PHOSPHOGLYCERATE DEHYDROGENASE PRECURSO... 256 2e-67
pir||T35831 probable D-3-phosphoglycerate dehydrogenase - Strept... 255 5e-67
sp|O08651|SERA_RAT D-3-PHOSPHOGLYCERATE DEHYDROGENASE (PGDH) >gi... 253 2e-66
gi|11422415 phosphoglycerate dehydrogenase [Homo sapiens] 252 5e-66
pir||T05416 probable phosphoglycerate dehydrogenase (EC 1.1.1.95... 251 6e-66
gi|5729974 phosphoglycerate dehydrogenase; 3-phosphoglycerate de... 250 1e-65
pir||A70464 D-3-phosphoglycerate dehydrogenase - Aquifex aeolicu... 249 3e-65
sp|O53243|SERA_MYCTU D-3-PHOSPHOGLYCERATE DEHYDROGENASE (PGDH) >... 248 5e-65
sp|O33116|SERA_MYCLE D-3-PHOSPHOGLYCERATE DEHYDROGENASE (PGDH) >... 246 2e-64
dbj|BAA99698.1| (AB025624) phosphoglycerate dehydrogenase [Arabi... 245 5e-64
pir||A72390 hypothetical protein TM0327 - Thermotoga maritima (s... 242 3e-63
dbj|BAB05321.1| (AP001512) D-3-phosphoglycerate dehydrogenase [B... 240 2e-62
pir||H70032 glycerate dehydrogenase homolog yvcT - Bacillus subt... 239 3e-62
emb|CAB08066.1| (Z94043) hypothetical protein [Bacillus subtilis] 234 1e-60
pir||T19602 hypothetical protein C31C9.2 - Caenorhabditis elegan... 232 5e-60
pir||A75414 D-3-phosphoglycerate dehydrogenase - Deinococcus rad... 231 6e-60
gb|AAF19554.1|AC005761_2 (AC005761) D-3-phosphoglycerate dehydro... 228 9e-59
sp|P43885|SERA_HAEIN D-3-PHOSPHOGLYCERATE DEHYDROGENASE (PGDH) >... 228 9e-59
sp|Q61753|SERA_MOUSE D-3-PHOSPHOGLYCERATE DEHYDROGENASE (PGDH) (... 222 4e-57
sp|P35136|SERA_BACSU D-3-PHOSPHOGLYCERATE DEHYDROGENASE (PGDH) >... 221 9e-57
gb|AAF53080.1| (AE003631) CG6287 gene product [Drosophila melano... 220 1e-56
pir||C82072 D-3-phosphoglycerate dehydrogenase VC2481 [imported]... 220 1e-56
gb|AAK41187.1| D-3-phosphoglycerate dehydrogenase (serA-1) [Sulf... 220 2e-56
sp|P87228|SERA_SCHPO PUTATIVE D-3-PHOSPHOGLYCERATE DEHYDROGENASE... 215 4e-55
dbj|BAB12215.1| (AB032549) d-3-phosphoglycerate dehydrogenase [M... 215 5e-55
sp|P08328|SERA_ECOLI D-3-PHOSPHOGLYCERATE DEHYDROGENASE (PGDH) >... 214 9e-55
pdb|1PSD|A Chain A, D-3-Phosphoglycerate Dehydrogenase (Phosphog... 214 9e-55
pir||C83607 D-3-phosphoglycerate dehydrogenase PA0316 [imported]... 211 7e-54
gb|AAF00955.1|AF183408_3 (AF183408) McyI [Microcystis aeruginosa] 210 2e-53
gi|6320925 3-phosphoglycerate dehydrogenase; Ser3p [Saccharomyce... 206 2e-52
pir||D75067 probable dehydrogenase PAB1008 - Pyrococcus abyssi (... 206 2e-52
gi|6322116 3-phosphoglycerate dehydrogenase; Ser33p [Saccharomyc... 205 6e-52
pir||C81362 phosphoglycerate dehydrogenase (EC 1.1.1.95) Cj0891c... 203 2e-51
gi|11499368 2-hydroxyacid dehydrogenase, putative [Archaeoglobus... 202 4e-51
gb|AAC46259.1| (AF006000) D-3-phosphoglycerate dehydrogenase hom... 202 5e-51
emb|CAB61802.1| (AL133236) putative dehydrogenase [Streptomyces ... 200 1e-50
pir||C72483 probable formate dehydrogenase APE2507 - Aeropyrum p... 199 4e-50
pir||C71165 probable dehydrogenase - Pyrococcus horikoshii >gi|3... 196 4e-49
pir||E64569 phosphoglycerate dehydrogenase - Helicobacter pylori... 192 3e-48
pir||C71864 d-3-phosphoglycerate dehydrogenase - Helicobacter py... 192 3e-48
pir||B82587 D-3-phosphoglycerate dehydrogenase XF2206 [imported]... 186 2e-46
dbj|BAB07033.1| (AP001518) glycerate dehydrogenase [Bacillus hal... 186 2e-46
sp|Q59516|DHGY_METEX GLYCERATE DEHYDROGENASE (NADH-DEPENDENT HYD... 185 7e-46
pir||G70363 D-lactate dehydrogenase - Aquifex aeolicus >gi|29833... 184 1e-45
gi|9631622 contains D-isomer specific 2-hydroxyacid dehydrogenas... 180 2e-44
pir||S47774 hypothetical protein o365 - Escherichia coli >gi|466... 179 3e-44
pir||C65154 probable 2-hydroxyacid dehydrogenase in bisC-cspA in... 179 3e-44
sp|P37666|YIAE_ECOLI PROBABLE 2-HYDROXYACID DEHYDROGENASE IN BIS... 179 3e-44
gb|AAD21956.1| (AF101234) unknown [Staphylococcus aureus] 179 3e-44
emb|CAC11910.1| (AL445065) 2-hydroxyacid dehydrogenase related p... 177 2e-43
pir||C83158 probable 2-hydroxyacid dehydrogenase PA3896 [importe... 176 3e-43
pir||D83529 D-lactate dehydrogenase (fermentative) PA0927 [impor... 176 3e-43
sp|P52643|LDHD_ECOLI D-LACTATE DEHYDROGENASE (D-LDH) >gi|7431359... 173 2e-42
sp|O88712|CTB1_MOUSE C-TERMINAL BINDING PROTEIN 1 >gi|3452507|em... 171 1e-41
gi|4557497 C-terminal binding protein 1 [Homo sapiens] >gi|11436... 171 1e-41
gi|7304989 C-terminal binding protein 1 [Mus musculus] >gi|60154... 171 1e-41
sp|P44501|DDH_HAEIN 2-HYDROXYACID DEHYDROGENASE HOMOLOG >gi|1073... 170 2e-41
pir||F69895 phosphoglycerate dehydrogenase homolog yoaD - Bacill... 170 2e-41
gb|AAF51963.1| (AE003602) CG1236 gene product [Drosophila melano... 170 2e-41
gi|9506527 C-terminal binding protein 1 [Rattus norvegicus] >gi|... 169 3e-41
pir||F81053 D-lactate dehydrogenase NMB1685 [imported] - Neisser... 169 3e-41
pir||F83362 probable 2-hydroxyacid dehydrogenase PA2263 [importe... 169 3e-41
pir||S75499 D-isomer specific 2-hydroxyacid dehydrogenase family... 169 3e-41
pir||C81380 probable D-2-hydroxyacid dehydrogenase Cj0373 [impor... 169 4e-41
sp|P45250|YF56_HAEIN PUTATIVE 2-HYDROXYACID DEHYDROGENASE HI1556... 168 6e-41
gb|AAD14596.1| (AF091554) C-terminal binding protein [Xenopus la... 168 1e-40
pir||F81822 D-lactate dehydrogenase (EC 1.1.1.28) NMA1944 [impor... 167 2e-40
gb|AAF53930.1| (AE003668) CG9332 gene product [Drosophila melano... 166 4e-40
emb|CAB92262.1| (AL356595) putative 2-hydroxyacid dehydrogenase ... 165 5e-40
sp|P30799|DDH_ZYMMO 2-HYDROXYACID DEHYDROGENASE HOMOLOG >gi|5387... 165 7e-40
pir||A82490 D-lactate dehydrogenase VCA0192 [imported] - Vibrio ... 165 7e-40
gb|AAC28494.1| (AF079881) D-3-phosphoglycerate dehydrogenase [En... 164 1e-39
gb|AAD41370.1|AF152006_1 (AF152006) Tcf-3 co-repressor CtBP [Xen... 164 1e-39
gi|6753548 C-terminal binding protein 2 [Mus musculus] >gi|35135... 163 2e-39
pir||S48189 hydroxypyruvate reductase (EC 1.1.1.81) - Hyphomicro... 163 3e-39
gi|4557499 C-terminal binding protein 2 [Homo sapiens] >gi|11432... 163 3e-39
pir||S45534 phosphoglycerate dehydrogenase (EC 1.1.1.95) - Bacil... 162 3e-39
pir||F82068 2-hydroxyacid dehydrogenase family protein VC2504 [i... 162 3e-39
gb|AAF16561.1|AC012563_14 (AC012563) hydroxypyruvate reductase (... 162 4e-39
pir||F82022 probable glycerate dehydrogenase (EC 1.1.1.29) NMA02... 162 4e-39
sp|P56546|CTB2_MOUSE C-TERMINAL BINDING PROTEIN 2 >gi|2909779|gb... 162 6e-39
pir||H81245 glycerate dehydrogenase NMB0029 [imported] - Neisser... 161 8e-39
gb|AAF09059.1|AC011717_26 (AC011717) putative D-isomer specific ... 161 1e-38
dbj|BAA19751.1| (D85339) hydroxypyruvate reductase [Arabidopsis ... 160 2e-38
gb|AAG18731.1| (AE004977) phosphoglycerate dehydrogenase; SerA3 ... 160 2e-38
dbj|BAA36181.1| (D88272) formate dehydrogenase [Hordeum vulgare] 159 4e-38
gb|AAD51414.1|AF171236_1 (AF171236) 3-phosphoglycerate dehydroge... 159 4e-38
pir||T42743 hypothetical protein - fission yeast (Schizosaccharo... 159 5e-38
pir||T41705 probable 2-hydroxyacid dehydrogenase - fission yeast... 159 5e-38
dbj|BAA25287.1| (AB011840) CtBP [Drosophila melanogaster] 158 7e-38
pir||C70645 hypothetical protein Rv0728c - Mycobacterium tubercu... 158 7e-38
sp|Q59642|LDHD_PEDAC D-LACTATE DEHYDROGENASE (D-LDH) >gi|897794|... 158 9e-38
pir||T50134 2-hydroxyacid dehydrogenase [imported] - fission yea... 158 9e-38
emb|CAA12074.1| (AJ224690) C-terminal binding protein [Drosophil... 157 1e-37
gb|AAF54891.1| (AE003698) CtBP gene product [alt 2] [Drosophila ... 157 1e-37
pir||T51423 formate dehydrogenase (FDH) - Arabidopsis thaliana >... 157 2e-37
gb|AAF79644.1|AC025416_18 (AC025416) F5O11.29 [Arabidopsis thali... 157 2e-37
sp|Q07511|FDH_SOLTU MITOCHONDRIAL FORMATE DEHYDROGENASE PRECURSO... 156 3e-37
gi|6912396 glyoxylate reductase/hydroxypyruvate reductase [Homo ... 155 6e-37
pir||S76782 D-2-hydroxy-acid dehydrogenase (EC 1.1.99.6) - Synec... 155 7e-37
pir||S68164 glycerate dehydrogenase (EC 1.1.1.29) splice form HP... 154 1e-36
pir||S68165 glycerate dehydrogenase (EC 1.1.1.29) splice form HP... 154 1e-36
sp|P13443|DHGY_CUCSA GLYCERATE DEHYDROGENASE (NADH-DEPENDENT HYD... 153 2e-36
gi|6324055 Ynl274cp [Saccharomyces cerevisiae] >gi|1730640|sp|P5... 153 2e-36
dbj|BAA77337.1| (AB019533) Nad-dependent formate dehydrogenase [... 152 4e-36
sp|P36234|DHGY_HYPME GLYCERATE DEHYDROGENASE (NADH-DEPENDENT HYD... 152 6e-36
pir||T50129 2-hydroxyacid dehydrogenase homolog [imported] - fis... 152 6e-36
pdb|1GDH|A Chain A, D-Glycerate Dehydrogenase (Apo Form) (E.C.1.... 151 1e-35
pir||H64531 phosphoglycerate dehydrogenase - Helicobacter pylori... 151 1e-35
pir||F83066 glycerate dehydrogenase PA4626 [imported] - Pseudomo... 149 3e-35
pir||T00876 hypothetical protein F17K2.16 - Arabidopsis thaliana... 148 6e-35
pir||D71373 probable D-specific D-2-hydroxyacid dehydrogenase - ... 147 1e-34
pir||G71974 probable keto-acid dehydrogenase - Helicobacter pylo... 147 2e-34
emb|CAA73696.1| (Y13245) NAD-dependent formate dehydrogenase [Mo... 146 3e-34
gb|AAG10470.1|AF279106_32 (AF279106) predicted NAD-dependent for... 146 4e-34
sp|P26298|LDHD_LACPE D-LACTATE DEHYDROGENASE (D-LDH) >gi|98677|p... 145 5e-34
gb|AAG34690.1|AF310956_5 (AF310956) D-2-hydroxyacid dehydrogenas... 144 1e-33
pir||DELBC D-2-hydroxyisocaproate dehydrogenase (EC 1.1.1.-) - L... 144 1e-33
sp|P17584|DHD2_LACCA D-2-HYDROXYISOCAPROATE DEHYDROGENASE (D-HIC... 144 1e-33
sp|Q07103|FDH_NEUCR FORMATE DEHYDROGENASE (NAD-DEPENDENT FORMATE... 143 2e-33
gb|AAG37025.1|AF277571_2 (AF277571) alpha keto acid dehydrogenas... 143 2e-33
gb|AAC49766.1| (AF004096) NAD-dependent formate dehydrogenase [C... 142 5e-33
emb|CAA09466.2| (AJ011046) formate dehydrogenase [Candida boidinii] 141 7e-33
gb|AAF36802.1|AF155139_1 (AF155139) putative lactate dehydrogena... 141 9e-33
pir||JC4252 formate dehydrogenase (EC 1.2.1.2) - yeast (Candida ... 141 1e-32
emb|CAA42781.1| (X60220) D-lactate dehydrogenase [Lactobacillus... 140 2e-32
gb|AAC99363.1| (AF071558) D-lactate dehydrogenase [Lactobacillus... 140 2e-32
gi|6324964 similar to formate dehydrogenases; Fdh1p [Saccharomyc... 138 6e-32
sp|Q47748|VANH_ENTFA D-SPECIFIC ALPHA-KETO ACID DEHYDROGENASE (V... 138 8e-32
gb|AAC23583.1| (U82965) D-lactate dehydrogenase [Streptomyces to... 138 8e-32
pir||D82435 D-3-phosphoglycerate dehydrogenase-related protein V... 138 8e-32
gb|AAD19834.1| (AF060799) D-lactate dehydrogenase [Amycolatopsis... 138 1e-31
sp|P30901|LDHD_LACHE D-LACTATE DEHYDROGENASE (D-LDH) >gi|478777|... 137 1e-31
gb|AAF72362.1|AF192329_23 (AF192329) VanHB [Enterococcus faecalis] 137 2e-31
sp|P26297|LDHD_LACDE D-LACTATE DEHYDROGENASE (D-LDH) >gi|538959|... 136 3e-31
prf||2124425A CtBP protein [Rattus norvegicus] 136 4e-31
pir||T35362 probable D-lactate dehydrogenase - Streptomyces coel... 134 2e-30
gb|AAC71709.1| (AF061070) PtxD [Pseudomonas stutzeri] 132 4e-30
pir||C83473 erythronate-4-phosphate dehydrogenase PA1375 [import... 132 4e-30
gb|AAF53929.1| (AE003668) CG9331 gene product [Drosophila melano... 132 5e-30
gb|AAG21503.1|AC067754_18 (AC067754) phosphoglycerate dehydrogen... 132 5e-30
pir||T34290 hypothetical protein F49E10.5 - Caenorhabditis elega... 132 6e-30
emb|CAA21970.1| (AL033497) YNL274C homologue [Candida albicans] 132 6e-30
sp|P51011|LDHD_LEUMC D-LACTATE DEHYDROGENASE (D-LDH) >gi|508506|... 130 2e-29
sp|P05459|PDXB_ECOLI ERYTHRONATE-4-PHOSPHATE DEHYDROGENASE >gi|6... 127 2e-28
emb|CAB55710.1| (AL117387) possible dehydrogenase [Streptomyces ... 126 3e-28
gb|AAB17663.1| (U31175) D-specific D-2-hydroxyacid dehydrogenase... 125 5e-28
pir||JC7190 D-2-hydroxy-acid dehydrogenase (EC 1.1.99.6) - human... 125 8e-28
gb|AAG19748.1| (AE005060) phosphoglycerate dehydrogenase; SerA2 ... 118 1e-25
emb|CAB56144.1| (AL117669) putative dehydrogenase [Streptomyces ... 114 1e-24
pir||D75365 probable 2-hydroxyacid dehydrogenase - Deinococcus r... 101 1e-20
gb|AAD41656.1|AF090993_1 (AF090993) D-2-hydroxyacid dehydrogenas... 82 6e-15
emb|CAA71175.1| (Y10086) putative dehydrogenase [Arabidopsis tha... 77 2e-13
emb|CAA73306.1| (Y12776) dehydrogenase [Arabidopsis thaliana] 77 2e-13
emb|CAA73307.1| (Y12776) gene5; most likely [Arabidopsis thaliana] 77 2e-13
gb|AAF81310.1|AC061957_6 (AC061957) Contains similarity to a deh... 77 2e-13
sp|P75913|YCDW_ECOLI PUTATIVE 2-HYDROXYACID DEHYDROGENASE IN PHO... 73 3e-12
dbj|BAA35814.1| (D90740) Hypothetical 33.0 kd protein in proB-pr... 73 3e-12
gi|6321253 Ygl185cp [Saccharomyces cerevisiae] >gi|1723944|sp|P5... 72 9e-12
>pir||B75120 phosphoglycerate dehydrogenase truncated homolog PAB0514 [imported]
- Pyrococcus abyssi (strain Orsay)
>gi|5458186|emb|CAB49675.1| (AJ248285) phosphoglycerate
dehydrogenase (serA), Nter fragment [Pyrococcus abyssi]
Length = 307
Score = 592 bits (1510), Expect = e-168
Identities = 307/307 (100%), Positives = 307/307 (100%)
Query: 1 MIEVKVLVAAPLHEKAIQILKDAGLEVIYEEYPEEDRLVELVKDVEAIIVRSKPKVTRKV 60
MIEVKVLVAAPLHEKAIQILKDAGLEVIYEEYPEEDRLVELVKDVEAIIVRSKPKVTRKV
Sbjct: 1 MIEVKVLVAAPLHEKAIQILKDAGLEVIYEEYPEEDRLVELVKDVEAIIVRSKPKVTRKV 60
Query: 61 IESAPKLKVIARAGVGLDNIDVEAAKERGIEVVNAPAASSRSVAELAVALMFAVARKIAF 120
IESAPKLKVIARAGVGLDNIDVEAAKERGIEVVNAPAASSRSVAELAVALMFAVARKIAF
Sbjct: 61 IESAPKLKVIARAGVGLDNIDVEAAKERGIEVVNAPAASSRSVAELAVALMFAVARKIAF 120
Query: 121 ADRKMREGVWAKKQAMGIELEGKTLGIIGFGRIGYQVAKIARALGMNLLLYDPYPNEERA 180
ADRKMREGVWAKKQAMGIELEGKTLGIIGFGRIGYQVAKIARALGMNLLLYDPYPNEERA
Sbjct: 121 ADRKMREGVWAKKQAMGIELEGKTLGIIGFGRIGYQVAKIARALGMNLLLYDPYPNEERA 180
Query: 181 KEVGGKFVDLETLLRESDIVTIHVPLLESTYHLINEERLKLMKKSAILINTSRGAVVDTN 240
KEVGGKFVDLETLLRESDIVTIHVPLLESTYHLINEERLKLMKKSAILINTSRGAVVDTN
Sbjct: 181 KEVGGKFVDLETLLRESDIVTIHVPLLESTYHLINEERLKLMKKSAILINTSRGAVVDTN 240
Query: 241 ALVKALEEGWIAGAGLDVYEEEPLPKDHPLTKFDNVVLTPHIGASTVEAQERAGVEVAEK 300
ALVKALEEGWIAGAGLDVYEEEPLPKDHPLTKFDNVVLTPHIGASTVEAQERAGVEVAEK
Sbjct: 241 ALVKALEEGWIAGAGLDVYEEEPLPKDHPLTKFDNVVLTPHIGASTVEAQERAGVEVAEK 300
Query: 301 VVKILKG 307
VVKILKG
Sbjct: 301 VVKILKG 307
>pir||E71011 probable phosphoglycerate dehydrogenase - Pyrococcus horikoshii
>gi|3257810|dbj|BAA30493.1| (AP000006) 307aa long
hypothetical phosphoglycerate dehydrogenase [Pyrococcus
horikoshii]
Length = 307
Score = 564 bits (1437), Expect = e-160
Identities = 286/307 (93%), Positives = 301/307 (97%)
Query: 1 MIEVKVLVAAPLHEKAIQILKDAGLEVIYEEYPEEDRLVELVKDVEAIIVRSKPKVTRKV 60
M +KVLVAAPLHEKAIQ+LKDAGLEVIYEEYP+EDRLVELVKDVEAIIVRSKPKVTR+V
Sbjct: 1 MKRMKVLVAAPLHEKAIQVLKDAGLEVIYEEYPDEDRLVELVKDVEAIIVRSKPKVTRRV 60
Query: 61 IESAPKLKVIARAGVGLDNIDVEAAKERGIEVVNAPAASSRSVAELAVALMFAVARKIAF 120
IESAPKLKVIARAGVGLDNIDVEAAKE+GIEVVNAPAASSRSVAELAV LMF+VARKIAF
Sbjct: 61 IESAPKLKVIARAGVGLDNIDVEAAKEKGIEVVNAPAASSRSVAELAVGLMFSVARKIAF 120
Query: 121 ADRKMREGVWAKKQAMGIELEGKTLGIIGFGRIGYQVAKIARALGMNLLLYDPYPNEERA 180
ADRKMREGVWAKK+AMGIELEGKT+GIIGFGRIGYQVAKIA ALGMN+LLYDPYPNEERA
Sbjct: 121 ADRKMREGVWAKKEAMGIELEGKTIGIIGFGRIGYQVAKIANALGMNILLYDPYPNEERA 180
Query: 181 KEVGGKFVDLETLLRESDIVTIHVPLLESTYHLINEERLKLMKKSAILINTSRGAVVDTN 240
KEV GKFVDLETLL+ESD+VTIHVPL+ESTYHLINEERLKLMKK+AILINTSRG VVDTN
Sbjct: 181 KEVNGKFVDLETLLKESDVVTIHVPLVESTYHLINEERLKLMKKTAILINTSRGPVVDTN 240
Query: 241 ALVKALEEGWIAGAGLDVYEEEPLPKDHPLTKFDNVVLTPHIGASTVEAQERAGVEVAEK 300
ALVKAL+EGWIAGAGLDV+EEEPLPKDHPLTKFDNVVLTPHIGASTVEAQERAGVEVAEK
Sbjct: 241 ALVKALKEGWIAGAGLDVFEEEPLPKDHPLTKFDNVVLTPHIGASTVEAQERAGVEVAEK 300
Query: 301 VVKILKG 307
VVKILKG
Sbjct: 301 VVKILKG 307
>sp|O27051|SERA_METTH D-3-PHOSPHOGLYCERATE DEHYDROGENASE (PGDH) >gi|7431368|pir||H69229
phosphoglycerate dehydrogenase - Methanobacterium
thermoautotrophicum (strain Delta H)
>gi|2622068|gb|AAB85466.1| (AE000870) phosphoglycerate
dehydrogenase [Methanobacterium thermoautotrophicum]
Length = 525
Score = 332 bits (843), Expect = 3e-90
Identities = 169/307 (55%), Positives = 231/307 (75%), Gaps = 2/307 (0%)
Query: 1 MIEVKVLVAAPLHEKAIQILKDAGLEVIYEEYPEEDRLVELVKDVEAIIVRSKPKVTRKV 60
M +KVL+A ++EK I L++ EV+ + L++ +KD +AI+VRS+ KVTR+V
Sbjct: 1 MSRMKVLIADSINEKGISELEEVA-EVVVNTTITPEELLDAIKDFDAIVVRSRTKVTREV 59
Query: 61 IESAPKLKVIARAGVGLDNIDVEAAKERGIEVVNAPAASSRSVAELAVALMFAVARKIAF 120
IE+AP+LK+IARAGVG+DN+DV+AA +RGI V+NAP ++S +VAE ++ LM A+ARKIA
Sbjct: 60 IEAAPRLKIIARAGVGVDNVDVKAATDRGIMVINAPESTSITVAEHSIGLMLALARKIAI 119
Query: 121 ADRKMREGVWAKKQAMGIELEGKTLGIIGFGRIGYQVAKIARALGMNLLLYDPYPNEERA 180
ADR ++EG W K + MGIEL GKTLGIIG GRIG QV +A GM++++YDPY ++E A
Sbjct: 120 ADRSVKEGKWEKNRFMGIELNGKTLGIIGMGRIGSQVVVRTKAFGMDIMVYDPYISKEAA 179
Query: 181 KEVGGKFVDLETLLRESDIVTIHVPLLESTYHLINEERLKLMKKSAILINTSRGAVVDTN 240
+E+G DLETLLRESDIVTIHVPL T HLI+E+ KLMK +A ++N +RG ++D +
Sbjct: 180 EEMGVTVTDLETLLRESDIVTIHVPLTPETRHLISEDEFKLMKDTAFIVNCARGGIIDED 239
Query: 241 ALVKALEEGWIAGAGLDVYEEEPLPKDHPLTKFDNVVLTPHIGASTVEAQERAGVEVAEK 300
AL +AL++G IAGA LDV+EEEP P+ PL + +NVVLTPHIGAST EAQ A + VA +
Sbjct: 240 ALYRALKDGEIAGAALDVFEEEP-PEGSPLLELENVVLTPHIGASTSEAQRDAAIIVANE 298
Query: 301 VVKILKG 307
+ + +G
Sbjct: 299 IKTVFQG 305
>sp|Q58424|SERA_METJA D-3-PHOSPHOGLYCERATE DEHYDROGENASE (PGDH) >gi|2129189|pir||A64427
phosphoglycerate dehydrogenase (EC 1.1.1.95) -
Methanococcus jannaschii >gi|1591676|gb|AAB99020.1|
(U67544) phosphoglycerate dehydrogenase (serA)
[Methanococcus jannaschii]
Length = 524
Score = 313 bits (793), Expect = 2e-84
Identities = 168/305 (55%), Positives = 218/305 (71%), Gaps = 3/305 (0%)
Query: 4 VKVLVAAPLHEKAIQILKDAGLEVIYEEYPEEDRLVELVKDVEAIIVRSKPKVTRKVIES 63
VK+LV PLHE AI+IL++ G EV ++ L+E +KD + ++VRS KVTR VIE
Sbjct: 2 VKILVTDPLHEDAIKILEEVG-EVEVATGLTKEELLEKIKDADVLVVRSGTKVTRDVIEK 60
Query: 64 APKLKVIARAGVGLDNIDVEAAKERGIEVVNAPAASSRSVAELAVALMFAVARKIAFADR 123
A KLKVI RAGVG+DNIDVEAA E+GI VVNAP ASS SVAEL + LM A AR I A
Sbjct: 61 AEKLKVIGRAGVGVDNIDVEAATEKGIIVVNAPDASSISVAELTMGLMLAAARNIPQATA 120
Query: 124 KMREGVWAKKQAMGIELEGKTLGIIGFGRIGYQVAKIARALGMNLLLYDPYPNEERAKEV 183
++ G W +K+ GIEL GKTLG+IG GRIG QV K A+A GMN++ YDPY +E A+ +
Sbjct: 121 SLKRGEWDRKRFKGIELYGKTLGVIGLGRIGQQVVKRAKAFGMNIIGYDPYIPKEVAESM 180
Query: 184 GGKFV-DLETLLRESDIVTIHVPLLESTYHLINEERLKLMKKSAILINTSRGAVVDTNAL 242
G + V D+ L + +D +T+HVPL T H+I E++ LMKK+AI++N +RG ++D AL
Sbjct: 181 GVELVDDINELCKRADFITLHVPLTPKTRHIIGREQIALMKKNAIIVNCARGGLIDEKAL 240
Query: 243 VKALEEGWIAGAGLDVYEEEPLPKDHPLTKFDNVVLTPHIGASTVEAQERAGVEVAEKVV 302
+AL+EG I A LDV+EEEP PKD+PL DNV+ TPH GAST EAQ+ AG VAE++
Sbjct: 241 YEALKEGKIRAAALDVFEEEP-PKDNPLLTLDNVIGTPHQGASTEEAQKAAGTIVAEQIK 299
Query: 303 KILKG 307
K+L+G
Sbjct: 300 KVLRG 304
>gi|11498419 phosphoglycerate dehydrogenase (serA) [Archaeoglobus fulgidus]
>gi|3122861|sp|O29445|SERA_ARCFU D-3-PHOSPHOGLYCERATE
DEHYDROGENASE (PGDH) >gi|7431372|pir||E69351
phosphoglycerate dehydrogenase (serA) homolog -
Archaeoglobus fulgidus >gi|2649798|gb|AAB90429.1|
(AE001048) phosphoglycerate dehydrogenase (serA)
[Archaeoglobus fulgidus]
Length = 527
Score = 309 bits (782), Expect = 4e-83
Identities = 156/304 (51%), Positives = 214/304 (70%)
Query: 4 VKVLVAAPLHEKAIQILKDAGLEVIYEEYPEEDRLVELVKDVEAIIVRSKPKVTRKVIES 63
+KVLVA P+ E+AI ++ GLEV + + L+ V EAI+VRS+ KV +VI++
Sbjct: 1 MKVLVAEPISEEAIDYMRKNGLEVEVKTGMSREELIREVPKYEAIVVRSQTKVDAEVIQA 60
Query: 64 APKLKVIARAGVGLDNIDVEAAKERGIEVVNAPAASSRSVAELAVALMFAVARKIAFADR 123
A LK+I RAGVG+DNID+ AA +RGI VVNAP ++ S AE A+ALM A ARKI ADR
Sbjct: 61 AKNLKIIGRAGVGVDNIDINAATQRGIVVVNAPGGNTISTAEHAIALMLAAARKIPQADR 120
Query: 124 KMREGVWAKKQAMGIELEGKTLGIIGFGRIGYQVAKIARALGMNLLLYDPYPNEERAKEV 183
++EG W +K+ MGIEL GKT G+IG GR+G++VAK +AL MN+L YDP+ ++ERA+++
Sbjct: 121 SVKEGKWERKKFMGIELRGKTAGVIGLGRVGFEVAKRCKALEMNVLAYDPFVSKERAEQI 180
Query: 184 GGKFVDLETLLRESDIVTIHVPLLESTYHLINEERLKLMKKSAILINTSRGAVVDTNALV 243
G K VD +TLL SD++T+HVP + T LI + + + MK I++N +RG +VD AL
Sbjct: 181 GVKLVDFDTLLASSDVITVHVPRTKETIGLIGKGQFEKMKDGVIVVNAARGGIVDEAALY 240
Query: 244 KALEEGWIAGAGLDVYEEEPLPKDHPLTKFDNVVLTPHIGASTVEAQERAGVEVAEKVVK 303
+A++ G +A A LDVYE+EP D+PL K DNVV TPHI AST EAQ G+ +AE +V
Sbjct: 241 EAIKAGKVAAAALDVYEKEPPSPDNPLLKLDNVVTTPHIAASTREAQLNVGMIIAEDIVN 300
Query: 304 ILKG 307
+ KG
Sbjct: 301 MAKG 304
>pir||B72257 D-3-phosphoglycerate dehydrogenase - Thermotoga maritima (strain
MSB8) >gi|4981965|gb|AAD36472.1|AE001793_2 (AE001793)
D-3-phosphoglycerate dehydrogenase [Thermotoga maritima]
Length = 306
Score = 284 bits (719), Expect = 9e-76
Identities = 152/308 (49%), Positives = 206/308 (66%), Gaps = 7/308 (2%)
Query: 1 MIEVKVLVAAPLHEKAIQILKDAGLEVIYEEYPEEDRLVELVKDVEAIIVRSKPKVTRKV 60
M +V V PL ++A Q+L + + E+ E+D L++++ +V+ ++VRS KVT +
Sbjct: 1 MARYRVHVNDPLDKEATQLLMNKEELEVTSEHLEKDELMKIIPEVDVLVVRSATKVTADI 60
Query: 61 IESAPKLKVIARAGVGLDNIDVEAAKERGIEVVNAPAASSRSVAELAVALMFAVARKIAF 120
IE+ LK+IARAG+GLDNIDV+ AKE+GI+V+N P AS+ SVAELA+ LM A AR IA
Sbjct: 61 IEAGKNLKIIARAGIGLDNIDVQKAKEKGIKVLNTPGASAPSVAELAMGLMLACARHIAR 120
Query: 121 ADRKMREGVWAKKQAMGIELEGKTLGIIGFGRIGYQVAKIARALGMNLLLYDPYPNEERA 180
A ++EG W KK G EL GKTLG+IGFG IG +VAK A A GM ++ YDP E
Sbjct: 121 ATVSLKEGKWEKKALKGKELLGKTLGLIGFGNIGQEVAKRALAFGMKIIAYDPAKPE--- 177
Query: 181 KEVGGKFVDLETLLRESDIVTIHVPLLESTYHLINEERLKLMKKSAILINTSRGAVVDTN 240
++ ++VDL+TL +ESD +++HVPL EST H+IN E + MK I++NT+RG +D
Sbjct: 178 TDLPVEYVDLDTLFKESDFISLHVPLTESTRHIINRESIAKMKDGVIIVNTARGGTIDEE 237
Query: 241 ALVKALEEGWIAGAGLDVYEEEPLPKD---HPLTKFDNVVLTPHIGASTVEAQERAGVEV 297
AL + + G + AGLDV+E EP P D L DNVV TPHIGAST EAQ R G+E+
Sbjct: 238 ALYEEVVSGKVYAAGLDVFEVEP-PTDEIRRKLLSLDNVVATPHIGASTAEAQRRVGIEL 296
Query: 298 AEKVVKIL 305
EK+ K L
Sbjct: 297 VEKIFKEL 304
>gb|AAG20511.1| (AE005123) phosphoglycerate dehydrogenase; SerA1 [Halobacterium sp.
NRC-1]
Length = 527
Score = 270 bits (684), Expect = 1e-71
Identities = 142/304 (46%), Positives = 194/304 (63%), Gaps = 1/304 (0%)
Query: 4 VKVLVAAPLHEKAIQILKDAGLEVIYEEYPEEDRLVELVKDVEAIIVRSKPKVTRKVIES 63
++VLV P+ + + L+DAG EV D L++ V D A+IVRS VT V E+
Sbjct: 1 MRVLVTDPIADAGLDRLRDAGHEVTTAYDATGDALLDAVSDAHALIVRSGTAVTDAVFEA 60
Query: 64 APKLKVIARAGVGLDNIDVEAAKERGIEVVNAPAASSRSVAELAVALMFAVARKIAFADR 123
AP L ++ARAG+G+DNID++AA + G+ V NAPA + R+ AE VAL FA AR I A
Sbjct: 61 APDLVIVARAGIGVDNIDIDAATDHGVMVANAPAGNVRAAAEHTVALAFAAARSIPQAHA 120
Query: 124 KMREGVWAKKQAMGIELEGKTLGIIGFGRIGYQVAKIARALGMNLLLYDPYPNEERAKEV 183
++ G WAK +G EL GKTLG++G GR+G +VA +LGM+L+ YDPY E+RA ++
Sbjct: 121 RLDAGSWAKDDYLGTELSGKTLGVVGLGRVGQEVATRLDSLGMDLVAYDPYIGEDRAAQL 180
Query: 184 GGKFVDLETLLRESDIVTIHVPLLESTYHLINEERLKLMKKSAILINTSRGAVVDTNALV 243
G + VD+ET + +D +TIHVPL + T LI E L M +IN +RG VVD +AL
Sbjct: 181 GAELVDIETCVARADFLTIHVPLTDETDGLIGEAELARM-DGGYVINVARGGVVDEDALA 239
Query: 244 KALEEGWIAGAGLDVYEEEPLPKDHPLTKFDNVVLTPHIGASTVEAQERAGVEVAEKVVK 303
A ++G IAGA LDV+ EPLP PL D+++ TPH+GAST AQE + A++VV
Sbjct: 240 DAAQDGVIAGAALDVFRTEPLPAASPLHDADSIITTPHLGASTKAAQENVATDTADQVVA 299
Query: 304 ILKG 307
L G
Sbjct: 300 ALAG 303
>pir||A71175 probable dehydrogenase - Pyrococcus horikoshii
>gi|3257003|dbj|BAA29686.1| (AP000002) 376aa long
hypothetical dehydrogenase [Pyrococcus horikoshii]
Length = 376
Score = 270 bits (682), Expect = 2e-71
Identities = 148/312 (47%), Positives = 202/312 (64%), Gaps = 10/312 (3%)
Query: 5 KVLVAAPLHEKAIQILKDAGLEVIYEEYPEEDR--LVELVKDVEAIIVRSKPKVTRKVIE 62
KV + + E I++L+D ++ + E R L++ VK+V+A++ ++ ++V E
Sbjct: 46 KVFITREIPEVGIKMLEDEFEVEVWGDEKEIPREILLKKVKEVDALVTMLSERIDKEVFE 105
Query: 63 SAPKLKVIARAGVGLDNIDVEAAKERGIEVVNAPAASSRSVAELAVALMFAVARKIAFAD 122
+APKL+++A VG DNID+E A +RGI V N P + + A+LA AL+ A AR + D
Sbjct: 106 NAPKLRIVANYAVGYDNIDIEEATKRGIYVTNTPDVLTDATADLAFALLLATARHVVKGD 165
Query: 123 RKMREGVWAK-------KQAMGIELEGKTLGIIGFGRIGYQVAKIARALGMNLLLYDPYP 175
R +R G W K K +G ++ GKT+GIIG GRIG +AK A+ M +L Y
Sbjct: 166 RFVRSGEWKKRGVAWHPKWFLGYDVYGKTIGIIGLGRIGQAIAKRAKGFNMRILYYSRTR 225
Query: 176 NEERAKEVGGKFVDLETLLRESDIVTIHVPLLESTYHLINEERLKLMKKSAILINTSRGA 235
EE +E+ +F LE LLRESD V + VPL TYHLINEERLKLMKK+AILIN +RG
Sbjct: 226 KEEVERELNAEFKPLEDLLRESDFVVLAVPLTRETYHLINEERLKLMKKTAILINIARGK 285
Query: 236 VVDTNALVKALEEGWIAGAGLDVYEEEPLPKDHPLTKFDNVVLTPHIGASTVEAQERAGV 295
VVDTNALVKAL+EGWIAGAGLDV+EEEP + L K DNVVLTPHIG+++ A+E
Sbjct: 286 VVDTNALVKALKEGWIAGAGLDVFEEEPYYNEE-LFKLDNVVLTPHIGSASFGAREGMAE 344
Query: 296 EVAEKVVKILKG 307
VA+ ++ +G
Sbjct: 345 LVAKNLIAFKRG 356
>pir||B75057 glycerate dehydrogenase PAB2374 - Pyrococcus abyssi (strain Orsay)
>gi|5458864|emb|CAB50351.1| (AJ248287) GLYCERATE
DEHYDROGENASE [Pyrococcus abyssi]
Length = 335
Score = 268 bits (678), Expect = 6e-71
Identities = 147/316 (46%), Positives = 201/316 (63%), Gaps = 10/316 (3%)
Query: 1 MIEVKVLVAAPLHEKAIQILKDAGLEVIYEEYPEEDR--LVELVKDVEAIIVRSKPKVTR 58
M + +V + + E I++L+ ++E+ E R L+E VKDV+A++ ++ R
Sbjct: 1 MSKPRVFITREIPEVGIEMLEKEFEVEVWEDEREIPREILLEKVKDVDALVTMLSERIDR 60
Query: 59 KVIESAPKLKVIARAGVGLDNIDVEAAKERGIEVVNAPAASSRSVAELAVALMFAVARKI 118
+V E AP+L+++A VG DNIDVE A +RGI V N P + + A+LA AL+ A AR +
Sbjct: 61 EVFERAPRLRIVANYAVGYDNIDVEEATKRGIYVTNTPGVLTDATADLAFALLLATARHL 120
Query: 119 AFADRKMREGVWAK-------KQAMGIELEGKTLGIIGFGRIGYQVAKIARALGMNLLLY 171
D+ R G W K K +G ++ GKT+GIIGFGRIG +AK AR M +L Y
Sbjct: 121 VKGDKFTRSGEWKKRGVAWHPKWFLGYDVYGKTIGIIGFGRIGQAIAKRARGFDMRILYY 180
Query: 172 DPYPNEERAKEVGGKFVDLETLLRESDIVTIHVPLLESTYHLINEERLKLMKKSAILINT 231
E KE+ +F L+ LLRESD V + VPL + TYH+INEERLK+MK++AILIN
Sbjct: 181 SRTRKPEVEKELNAEFKPLDELLRESDFVVLAVPLNKETYHMINEERLKMMKRTAILINV 240
Query: 232 SRGAVVDTNALVKALEEGWIAGAGLDVYEEEPLPKDHPLTKFDNVVLTPHIGASTVEAQE 291
+RG V+DT AL+KAL+EGWIAGAGLDVYEEEP + L DNVVLTPHIG++T A+E
Sbjct: 241 ARGKVIDTKALIKALKEGWIAGAGLDVYEEEPYYNEE-LFSLDNVVLTPHIGSATFGARE 299
Query: 292 RAGVEVAEKVVKILKG 307
VAE ++ +G
Sbjct: 300 GMAKLVAENLIAFKRG 315
>sp|P73821|SERA_SYNY3 D-3-PHOSPHOGLYCERATE DEHYDROGENASE (PGDH) >gi|7431369|pir||S75016
phosphoglycerate dehydrogenase - Synechocystis sp.
(strain PCC 6803) >gi|1652961|dbj|BAA17878.1| (D90910)
phosphoglycerate dehydrogenase [Synechocystis sp.]
Length = 554
Score = 268 bits (677), Expect = 7e-71
Identities = 139/303 (45%), Positives = 205/303 (66%), Gaps = 2/303 (0%)
Query: 5 KVLVAAPLHEKAIQILKDAGLEVIYEEYPEEDRLVELVKDVEAIIVRSKPKVTRKVIESA 64
KVLV+ + + I ILK +V + E ++++V + +AI++RS KVT K+I++
Sbjct: 31 KVLVSDSIDQVGIDILKQVA-QVDVKTGLSEAEIIDIVPEYDAIMLRSATKVTEKIIQAG 89
Query: 65 PKLKVIARAGVGLDNIDVEAAKERGIEVVNAPAASSRSVAELAVALMFAVARKIAFADRK 124
+LK+I RAGVG+DNIDV AA +GI VVN+P ++ + AE A+A+M A+AR I A++
Sbjct: 90 SQLKIIGRAGVGVDNIDVPAATRQGIVVVNSPEGNTIAAAEHALAMMMALARHIPDANKS 149
Query: 125 MREGVWAKKQAMGIELEGKTLGIIGFGRIGYQVAKIARALGMNLLLYDPYPNEERAKEVG 184
++E W +KQ +G E+ KTLG++G G+IG VA +A+A+GM LL YDP+ ++ERA ++G
Sbjct: 150 VKESKWERKQFIGTEVYKKTLGVVGLGKIGSHVAGVAKAMGMKLLAYDPFISQERADQIG 209
Query: 185 GKFVDLETLLRESDIVTIHVPLLESTYHLINEERLKLMKKSAILINTSRGAVVDTNALVK 244
VDL+ L E+D +T+H+P T +LIN E L MK +A +IN SRG ++D ALV
Sbjct: 210 CTLVDLDLLFSEADFITLHIPKTPETANLINAETLAKMKPTARIINCSRGGIIDEEALVT 269
Query: 245 ALEEGWIAGAGLDVYEEEPLPKDHPLTKFDNVVLTPHIGASTVEAQERAGVEVAEKVVKI 304
A+E I GA LDV+ +EPL + L +F NV+LTPH+GAST EAQ V+VAE++ +
Sbjct: 270 AIETAQIGGAALDVFAQEPLGESR-LREFSNVILTPHLGASTEEAQVNVAVDVAEQIRDV 328
Query: 305 LKG 307
L G
Sbjct: 329 LLG 331
>pir||E72568 probable D-3-phosphoglycerate dehydrogenase APE1831 - Aeropyrum
pernix (strain K1) >gi|5105521|dbj|BAA80834.1|
(AP000062) 347aa long hypothetical D-3-phosphoglycerate
dehydrogenase [Aeropyrum pernix]
Length = 347
Score = 257 bits (651), Expect = 8e-68
Identities = 135/312 (43%), Positives = 195/312 (62%), Gaps = 9/312 (2%)
Query: 5 KVLVAAPLHEKAIQILKDAGLEVIYEEY--PEEDRLVELVKDVEAIIVRSKPKVTRKVIE 62
+V V + +A+++L ++++Y P + L+ ++ +A+ ++ ++
Sbjct: 17 RVFVTREVFPEALELLSKYYDVEVWDKYQPPPYETLLSKAREADALYTLLTDRIDCDLLS 76
Query: 63 SAPKLKVIARAGVGLDNIDVEAAKERGIEVVNAPAASSRSVAELAVALMFAVARKIAFAD 122
AP+L+++A+ VG DNIDVE A GI V N P + + AE AL+ A AR++ AD
Sbjct: 77 QAPRLRIVAQMAVGFDNIDVECATRLGIYVTNTPGVLTEATAEFTWALILAAARRVVEAD 136
Query: 123 RKMREGVWAKKQA-------MGIELEGKTLGIIGFGRIGYQVAKIARALGMNLLLYDPYP 175
+R G W + + +G+EL GKTLGI+G GRIG +VA+I +A GM ++ +
Sbjct: 137 HFVRWGEWWRLRTGWHPMMMLGVELRGKTLGILGMGRIGSRVAEIGKAFGMRIIYHSRSR 196
Query: 176 NEERAKEVGGKFVDLETLLRESDIVTIHVPLLESTYHLINEERLKLMKKSAILINTSRGA 235
E KE+G ++ LE LLRESDI++IH+PL + T HLI E LKLMKK+AIL+NT RGA
Sbjct: 197 KREIEKELGAEYRSLEDLLRESDILSIHLPLTDETRHLIGESELKLMKKTAILVNTGRGA 256
Query: 236 VVDTNALVKALEEGWIAGAGLDVYEEEPLPKDHPLTKFDNVVLTPHIGASTVEAQERAGV 295
+VDT ALVKAL EGWIA A LDV+EEEPL +HPLT F NVVL PH ++T E + R +
Sbjct: 257 IVDTGALVKALREGWIAAAALDVFEEEPLNPNHPLTAFKNVVLAPHAASATRETRLRMAM 316
Query: 296 EVAEKVVKILKG 307
AE +V +G
Sbjct: 317 MAAENLVAFAQG 328
>sp|O04130|SERA_ARATH D-3-PHOSPHOGLYCERATE DEHYDROGENASE PRECURSOR (PGDH)
>gi|2189964|dbj|BAA20405.1| (AB003280) Phosphoglycerate
dehydrogenase [Arabidopsis thaliana]
>gi|2804258|dbj|BAA24440.1| (AB010407) phosphoglycerate
dehydrogenase [Arabidopsis thaliana]
>gi|9802747|gb|AAF99816.1|AC034257_8 (AC034257)
D-3-phosphoglycerate dehydrogenase [Arabidopsis
thaliana]
Length = 624
Score = 256 bits (648), Expect = 2e-67
Identities = 133/305 (43%), Positives = 204/305 (66%), Gaps = 4/305 (1%)
Query: 5 KVLVAAPLHEKAIQILKDAG-LEVIYEEYPEEDRLVELVKDVEAIIVRSKPKVTRKVIES 63
++LV L E + +L++ G ++ Y+ PE+ L + V + +A+IVRS KVTR+V E+
Sbjct: 84 RILVTEKLGEAGVNLLREFGDVDCSYDLSPED--LKKKVAESDALIVRSGTKVTREVFEA 141
Query: 64 AP-KLKVIARAGVGLDNIDVEAAKERGIEVVNAPAASSRSVAELAVALMFAVARKIAFAD 122
A +LKV+ RAGVG+DN+D++AA E G VVNAP A++ + AE +AL+ ++AR +A AD
Sbjct: 142 AKGRLKVVGRAGVGIDNVDLQAATEHGCLVVNAPTANTVAAAEHGIALLASMARNVAQAD 201
Query: 123 RKMREGVWAKKQAMGIELEGKTLGIIGFGRIGYQVAKIARALGMNLLLYDPYPNEERAKE 182
++ G W + + +G+ L GKTL ++GFG++G +VA+ A+ LGM ++ +DPY +RA+
Sbjct: 202 ASIKAGKWERSKYVGVSLVGKTLAVMGFGKVGTEVARRAKGLGMTVISHDPYAPADRARA 261
Query: 183 VGGKFVDLETLLRESDIVTIHVPLLESTYHLINEERLKLMKKSAILINTSRGAVVDTNAL 242
+G V + + +D V++H+PL +T + N+E MKK LIN +RG V+D +AL
Sbjct: 262 LGVDLVSFDQAISTADFVSLHMPLTPATKKVFNDETFSKMKKGVRLINVARGGVIDEDAL 321
Query: 243 VKALEEGWIAGAGLDVYEEEPLPKDHPLTKFDNVVLTPHIGASTVEAQERAGVEVAEKVV 302
V+AL+ G +A A LDV+ EEP KD L + +NV +TPH+GAST EAQE +E+AE V
Sbjct: 322 VRALDAGIVAQAALDVFCEEPPSKDSRLIQHENVTVTPHLGASTKEAQEGVAIEIAEAVA 381
Query: 303 KILKG 307
LKG
Sbjct: 382 GALKG 386
>pir||T35831 probable D-3-phosphoglycerate dehydrogenase - Streptomyces
coelicolor >gi|4467266|emb|CAB37591.1| (AL035569)
probable D-3-phosphoglycerate dehydrogenase
[Streptomyces coelicolor A3(2)]
Length = 529
Score = 255 bits (644), Expect = 5e-67
Identities = 138/302 (45%), Positives = 191/302 (62%), Gaps = 2/302 (0%)
Query: 6 VLVAAPLHEKAIQILKDAGLEVIYEEYPEEDRLVELVKDVEAIIVRSKPKVTRKVIESAP 65
VL+A L + L E+ + + L+ + DV+AI+VRS KV + + +A
Sbjct: 7 VLIAEELSPATVDAL-GPDFEIRHCNGADRAELLPAIADVDAILVRSATKVDAEAVAAAK 65
Query: 66 KLKVIARAGVGLDNIDVEAAKERGIEVVNAPAASSRSVAELAVALMFAVARKIAFADRKM 125
KLKV+ARAGVGLDN+DV AA + G+ VVNAP ++ + AELA L+ A AR I A+ +
Sbjct: 66 KLKVVARAGVGLDNVDVSAATKAGVMVVNAPTSNIVTAAELACGLIVATARNIPQANAAL 125
Query: 126 REGVWAKKQAMGIELEGKTLGIIGFGRIGYQVAKIARALGMNLLLYDPYPNEERAKEVGG 185
+ G W + + G+EL KTLG++G GRIG VA+ A GM ++ YDPY RA ++G
Sbjct: 126 KNGEWKRSKYTGVELAEKTLGVVGLGRIGALVAQRMSAFGMKVVAYDPYVQPARAAQMGV 185
Query: 186 KFVDLETLLRESDIVTIHVPLLESTYHLINEERLKLMKKSAILINTSRGAVVDTNALVKA 245
K + L+ LL SD +T+H+P T LI +E L+ +K S ++N +RG +VD AL A
Sbjct: 186 KVLSLDELLEVSDFITVHLPKTPETLGLIGDEALRKVKPSVRIVNAARGGIVDEEALYSA 245
Query: 246 LEEGWIAGAGLDVYEEEPLPKDHPLTKFDNVVLTPHIGASTVEAQERAGVEVAEKVVKIL 305
L+EG +AGAGLDVY +EP D PL +FD VV TPH+GAST EAQE+AG+ VA+ V L
Sbjct: 246 LKEGRVAGAGLDVYAKEPC-TDSPLFEFDQVVATPHLGASTDEAQEKAGIAVAKSVRLAL 304
Query: 306 KG 307
G
Sbjct: 305 AG 306
>sp|O08651|SERA_RAT D-3-PHOSPHOGLYCERATE DEHYDROGENASE (PGDH)
>gi|1944614|emb|CAA66374.1| (X97772)
D-3-phosphoglycerate dehydrogenase [Rattus norvegicus]
>gi|7688285|emb|CAB89828.1| (AJ271975)
3-phosphoglycerate dehydrogenase [Rattus norvegicus]
Length = 533
Score = 253 bits (639), Expect = 2e-66
Identities = 132/303 (43%), Positives = 193/303 (63%), Gaps = 1/303 (0%)
Query: 5 KVLVAAPLHEKAIQILKDAGLEVIYEEYPEEDRLVELVKDVEAIIVRSKPKVTRKVIESA 64
K+L++ L +IL+D GL+V+ ++ ++ L+ ++D E +IVRS KVT VI +A
Sbjct: 8 KILISDSLDPCCRKILQDGGLQVVEKQNLSKEELIAELQDCEGLIVRSATKVTADVINAA 67
Query: 65 PKLKVIARAGVGLDNIDVEAAKERGIEVVNAPAASSRSVAELAVALMFAVARKIAFADRK 124
KL+V+ RAG G+DN+D+EAA +G+ V+N P +S S AEL ++ +AR+I A
Sbjct: 68 EKLQVVGRAGTGVDNVDLEAATRKGVLVMNTPNGNSLSAAELTCGMLMCLARQIPQATAS 127
Query: 125 MREGVWAKKQAMGIELEGKTLGIIGFGRIGYQVAKIARALGMNLLLYDPYPNEERAKEVG 184
M++G W +K+ MG EL GKTLGI+G GRIG +VA +A GM + YDP + E A G
Sbjct: 128 MKDGKWDRKKFMGTELNGKTLGILGLGRIGREVAARMQAFGMKTVGYDPIISPEVAASFG 187
Query: 185 GKFVDLETLLRESDIVTIHVPLLESTYHLINEERLKLMKKSAILINTSRGAVVDTNALVK 244
+ + LE + D +T+H PLL ST L+N+ KK ++N +RG +VD AL++
Sbjct: 188 VQQLPLEEIWPLCDFITVHTPLLPSTTGLLNDSTFAQCKKGVRVVNCARGGIVDEGALLR 247
Query: 245 ALEEGWIAGAGLDVYEEEPLPKDHPLTKFDNVVLTPHIGASTVEAQERAGVEVAEKVVKI 304
AL+ G AGA LDV+ EEP P+D L +NV+ PH+GAST EAQ R G E+A + V +
Sbjct: 248 ALQSGQCAGAALDVFTEEP-PRDRALVDHENVISCPHLGASTKEAQSRCGEEIAVQFVDM 306
Query: 305 LKG 307
+KG
Sbjct: 307 VKG 309
>gi|11422415 phosphoglycerate dehydrogenase [Homo sapiens]
Length = 569
Score = 252 bits (636), Expect = 5e-66
Identities = 132/303 (43%), Positives = 193/303 (63%), Gaps = 1/303 (0%)
Query: 5 KVLVAAPLHEKAIQILKDAGLEVIYEEYPEEDRLVELVKDVEAIIVRSKPKVTRKVIESA 64
KVL++ L +IL+D GL+V+ ++ ++ L+ ++D E +IVRS KVT VI +A
Sbjct: 44 KVLISDSLDPCCRKILQDGGLQVVEKQNLSKEELIAELQDCEGLIVRSATKVTADVINAA 103
Query: 65 PKLKVIARAGVGLDNIDVEAAKERGIEVVNAPAASSRSVAELAVALMFAVARKIAFADRK 124
KL+V+ RAG G+DN+D+EAA +GI V+N P +S S AEL ++ +AR+I A
Sbjct: 104 EKLQVVGRAGTGVDNVDLEAATRKGILVMNTPNGNSLSAAELTCGMIMCLARQIPQATAS 163
Query: 125 MREGVWAKKQAMGIELEGKTLGIIGFGRIGYQVAKIARALGMNLLLYDPYPNEERAKEVG 184
M++G W +K+ MG EL GKTLGI+G GRIG +VA ++ GM + YDP + E + G
Sbjct: 164 MKDGKWERKKFMGTELNGKTLGILGLGRIGREVATRMQSFGMKTIGYDPIISPEVSASFG 223
Query: 185 GKFVDLETLLRESDIVTIHVPLLESTYHLINEERLKLMKKSAILINTSRGAVVDTNALVK 244
+ + LE + D +T+H PLL ST L+N+ KK ++N +RG +VD AL++
Sbjct: 224 VQQLPLEEIWPLCDFITVHTPLLPSTTGLLNDNTFAQCKKGVRVVNCARGGIVDEGALLR 283
Query: 245 ALEEGWIAGAGLDVYEEEPLPKDHPLTKFDNVVLTPHIGASTVEAQERAGVEVAEKVVKI 304
AL+ G AGA LDV+ EEP P+D L +NV+ PH+GAST EAQ R G E+A + V +
Sbjct: 284 ALQSGQCAGAALDVFTEEP-PRDRALVDHENVISCPHLGASTKEAQSRCGEEIAVQFVDM 342
Query: 305 LKG 307
+KG
Sbjct: 343 VKG 345
>pir||T05416 probable phosphoglycerate dehydrogenase (EC 1.1.1.95) - Arabidopsis
thaliana >gi|2911042|emb|CAA17552.1| (AL021961)
Phosphoglycerate dehydrogenase-like protein [Arabidopsis
thaliana] >gi|7270370|emb|CAB80137.1| (AL161585)
Phosphoglycerate dehydrogenase-like protein [Arabidopsis
thaliana]
Length = 603
Score = 251 bits (635), Expect = 6e-66
Identities = 131/304 (43%), Positives = 200/304 (65%), Gaps = 4/304 (1%)
Query: 6 VLVAAPLHEKAIQILKD-AGLEVIYEEYPEEDRLVELVKDVEAIIVRSKPKVTRKVIESA 64
+LVA L + I++L+D A ++ Y PEE + + +A+IVRS KV R+V ES+
Sbjct: 64 ILVAEKLGDAGIKLLEDVANVDCSYNMTPEELNIK--ISLCDALIVRSGTKVGREVFESS 121
Query: 65 P-KLKVIARAGVGLDNIDVEAAKERGIEVVNAPAASSRSVAELAVALMFAVARKIAFADR 123
+LKV+ RAGVG+DN+D+ AA E G VVNAP A++ + AE +ALM A+AR +A AD
Sbjct: 122 HGRLKVVGRAGVGIDNVDLSAATEFGCLVVNAPTANTIAAAEHGIALMAAMARNVAQADA 181
Query: 124 KMREGVWAKKQAMGIELEGKTLGIIGFGRIGYQVAKIARALGMNLLLYDPYPNEERAKEV 183
++ G W + + +G+ L GKTL ++GFG++G +VA+ A+ LGM ++ +DPY +RA +
Sbjct: 182 SVKAGEWKRNKYVGVSLVGKTLAVLGFGKVGTEVARRAKGLGMRVIAHDPYAPADRAHAI 241
Query: 184 GGKFVDLETLLRESDIVTIHVPLLESTYHLINEERLKLMKKSAILINTSRGAVVDTNALV 243
G V + L +D +++H+PL +T ++N+E MKK ++N +RG V+D +ALV
Sbjct: 242 GVDLVSFDEALATADFISLHMPLTPTTSKILNDETFAKMKKGVRIVNVARGGVIDEDALV 301
Query: 244 KALEEGWIAGAGLDVYEEEPLPKDHPLTKFDNVVLTPHIGASTVEAQERAGVEVAEKVVK 303
+AL+ G +A A LDV+ +EP KD L + + V +TPH+GAST+EAQE +E+AE VV
Sbjct: 302 RALDAGIVAQAALDVFTKEPPAKDSKLVQHERVTVTPHLGASTMEAQEGVAIEIAEAVVG 361
Query: 304 ILKG 307
L G
Sbjct: 362 ALNG 365
>gi|5729974 phosphoglycerate dehydrogenase; 3-phosphoglycerate dehydrogenase
[Homo sapiens] >gi|6094272|sp|O43175|SERA_HUMAN
D-3-PHOSPHOGLYCERATE DEHYDROGENASE (PGDH)
>gi|2674062|gb|AAB88664.1| (AF006043) 3-phosphoglycerate
dehydrogenase [Homo sapiens]
>gi|5771523|gb|AAD51415.1|AF171237_1 (AF171237)
3-phosphoglycerate dehydrogenase [Homo sapiens]
Length = 533
Score = 250 bits (632), Expect = 1e-65
Identities = 131/303 (43%), Positives = 193/303 (63%), Gaps = 1/303 (0%)
Query: 5 KVLVAAPLHEKAIQILKDAGLEVIYEEYPEEDRLVELVKDVEAIIVRSKPKVTRKVIESA 64
KVL++ L +IL++ GL+V+ ++ ++ L+ ++D E +IVRS KVT VI +A
Sbjct: 8 KVLISDSLDPCCRKILQEGGLQVVEKQNLSKEELIAELQDCEGLIVRSATKVTADVINAA 67
Query: 65 PKLKVIARAGVGLDNIDVEAAKERGIEVVNAPAASSRSVAELAVALMFAVARKIAFADRK 124
KL+V+ RAG G+DN+D+EAA +GI V+N P +S S AEL ++ +AR+I A
Sbjct: 68 EKLQVVGRAGTGVDNVDLEAATRKGILVMNTPNGNSLSAAELTCGMIMCLARQIPQATAS 127
Query: 125 MREGVWAKKQAMGIELEGKTLGIIGFGRIGYQVAKIARALGMNLLLYDPYPNEERAKEVG 184
M++G W +K+ MG EL GKTLGI+G GRIG +VA ++ GM + YDP + E + G
Sbjct: 128 MKDGKWERKKFMGTELNGKTLGILGLGRIGREVATRMQSFGMKTIGYDPIISPEVSASFG 187
Query: 185 GKFVDLETLLRESDIVTIHVPLLESTYHLINEERLKLMKKSAILINTSRGAVVDTNALVK 244
+ + LE + D +T+H PLL ST L+N+ KK ++N +RG +VD AL++
Sbjct: 188 VQQLPLEEIWPLCDFITVHTPLLPSTTGLLNDNTFAQCKKGVRVVNCARGGIVDEGALLR 247
Query: 245 ALEEGWIAGAGLDVYEEEPLPKDHPLTKFDNVVLTPHIGASTVEAQERAGVEVAEKVVKI 304
AL+ G AGA LDV+ EEP P+D L +NV+ PH+GAST EAQ R G E+A + V +
Sbjct: 248 ALQSGQCAGAALDVFTEEP-PRDRALVDHENVISCPHLGASTKEAQSRCGEEIAVQFVDM 306
Query: 305 LKG 307
+KG
Sbjct: 307 VKG 309
>pir||A70464 D-3-phosphoglycerate dehydrogenase - Aquifex aeolicus
>gi|2984165|gb|AAC07698.1| (AE000762)
D-3-phosphoglycerate dehydrogenase [Aquifex aeolicus]
Length = 533
Score = 249 bits (629), Expect = 3e-65
Identities = 135/310 (43%), Positives = 196/310 (62%), Gaps = 7/310 (2%)
Query: 5 KVLVAAPLHEKAIQIL-KDAGLEVIYEEYPEEDRLVELVKDVEAIIVRSKPKVTRKVIES 63
KVL+ P+ + I++L KD +EV E + L+E++KD +AII RS+ VT++++E
Sbjct: 3 KVLITDPIAPEGIELLQKDPEVEVYNEPDISYEELLEIIKDFDAIITRSRTPVTKELLER 62
Query: 64 APKLKVIARAGVGLDNIDVEAAKERGIEVVNAPAASSRSVAELAVALMFAVARKIAFADR 123
A KLKV+ RAGVG+DN+D+E A +RGI VVN P A++ EL + M + R A
Sbjct: 63 AEKLKVVGRAGVGVDNVDIEEATKRGILVVNTPGANTIGATELTMMHMLTIMRNGHKAHE 122
Query: 124 KMREGVWAKKQAMGIELEGKTLGIIGFGRIGYQVAKIARALGMNLLLYDPYPNEERAKEV 183
M W +K+ MG EL G+ LGIIG G IG QVA A+A GM ++ YDPY E+A+++
Sbjct: 123 SMLNYKWDRKKFMGEELYGRILGIIGLGNIGSQVAIRAKAFGMKVMAYDPYIPREKAEKL 182
Query: 184 GGKFVD-LETLLRESDIVTIHVPLLESTYHLINEERLKLMKKSAILINTSRGAVVDTNAL 242
G K VD L +LRE D++TIH PL T ++I+E+ ++MK ++N +RG +++ AL
Sbjct: 183 GVKLVDNLHDMLREIDVLTIHAPLTHETKNMIDEKEFEIMKDGVYIVNCARGGIINEKAL 242
Query: 243 VKALEEGWIAGAGLDVYEEEPLPKD-----HPLTKFDNVVLTPHIGASTVEAQERAGVEV 297
+K +E G I G LDVY +EP P + L N+ L+PHIGA+T E+Q V V
Sbjct: 243 IKYMESGKIKGVALDVYSKEPPPPEFIDELKRLADKVNISLSPHIGANTYESQRNVAVIV 302
Query: 298 AEKVVKILKG 307
A++V+K LKG
Sbjct: 303 AQQVLKALKG 312
>sp|O53243|SERA_MYCTU D-3-PHOSPHOGLYCERATE DEHYDROGENASE (PGDH) >gi|7431374|pir||G70854
probable serA protein - Mycobacterium tuberculosis
(strain H37RV) >gi|2791593|emb|CAA16081.1| (AL021287)
serA [Mycobacterium tuberculosis]
Length = 528
Score = 248 bits (627), Expect = 5e-65
Identities = 132/302 (43%), Positives = 192/302 (62%), Gaps = 2/302 (0%)
Query: 6 VLVAAPLHEKAIQILKDAGLEVIYEEYPEEDRLVELVKDVEAIIVRSKPKVTRKVIESAP 65
VL+A L + L D +EV + + P+ D+L+ V + +A++VRS V +V+ +AP
Sbjct: 6 VLIADKLAPSTVAALGDQ-VEVRWVDGPDRDKLLAAVPEADALLVRSATTVDAEVLAAAP 64
Query: 66 KLKVIARAGVGLDNIDVEAAKERGIEVVNAPAASSRSVAELAVALMFAVARKIAFADRKM 125
KLK++ARAGVGLDN+DV+AA RG+ VVNAP ++ S AE A+AL+ A +R+I AD +
Sbjct: 65 KLKIVARAGVGLDNVDVDAATARGVLVVNAPTSNIHSAAEHALALLLAASRQIPAADASL 124
Query: 126 REGVWAKKQAMGIELEGKTLGIIGFGRIGYQVAKIARALGMNLLLYDPYPNEERAKEVGG 185
RE W + G E+ GKT+G++G GRIG VA+ A G ++ YDPY + RA ++G
Sbjct: 125 REHTWKRSSFSGTEIFGKTVGVVGLGRIGQLVAQRIAAFGAYVVAYDPYVSPARAAQLGI 184
Query: 186 KFVDLETLLRESDIVTIHVPLLESTYHLINEERLKLMKKSAILINTSRGAVVDTNALVKA 245
+ + L+ LL +D +++H+P T LI++E L K I++N +RG +VD AL A
Sbjct: 185 ELLSLDDLLARADFISVHLPKTPETAGLIDKEALAKTKPGVIIVNAARGGLVDEAALADA 244
Query: 246 LEEGWIAGAGLDVYEEEPLPKDHPLTKFDNVVLTPHIGASTVEAQERAGVEVAEKVVKIL 305
+ G + AGLDV+ EP D PL + VV+TPH+GAST EAQ+RAG +VAE V L
Sbjct: 245 ITGGHVRAAGLDVFATEPC-TDSPLFELAQVVVTPHLGASTAEAQDRAGTDVAESVRLAL 303
Query: 306 KG 307
G
Sbjct: 304 AG 305
>sp|O33116|SERA_MYCLE D-3-PHOSPHOGLYCERATE DEHYDROGENASE (PGDH) >gi|11251649|pir||T45418
phosphoglycerate dehydrogenase [imported] -
Mycobacterium leprae >gi|2414551|emb|CAB16440.1|
(Z99263) phosphoglycerate dehydrogenase [Mycobacterium
leprae]
Length = 528
Score = 246 bits (622), Expect = 2e-64
Identities = 130/302 (43%), Positives = 191/302 (63%), Gaps = 2/302 (0%)
Query: 6 VLVAAPLHEKAIQILKDAGLEVIYEEYPEEDRLVELVKDVEAIIVRSKPKVTRKVIESAP 65
VL+A L + + L D +EV + + P+ +L+ V + +A++VRS V +V+ +AP
Sbjct: 6 VLIADKLAQSTVAALGDQ-VEVRWVDGPDRTKLLAAVPEADALLVRSATTVDAEVLAAAP 64
Query: 66 KLKVIARAGVGLDNIDVEAAKERGIEVVNAPAASSRSVAELAVALMFAVARKIAFADRKM 125
KLK++ARAGVGLDN+DV+AA RG+ VVNAP ++ S AE A+AL+ A +R+IA AD +
Sbjct: 65 KLKIVARAGVGLDNVDVDAATARGVLVVNAPTSNIHSAAEHALALLLAASRQIAEADASL 124
Query: 126 REGVWAKKQAMGIELEGKTLGIIGFGRIGYQVAKIARALGMNLLLYDPYPNEERAKEVGG 185
R +W + G E+ GKT+G++G GRIG VA A G +++ YDPY RA ++G
Sbjct: 125 RAHIWKRSSFSGTEIFGKTVGVVGLGRIGQLVAARIAAFGAHVIAYDPYVAPARAAQLGI 184
Query: 186 KFVDLETLLRESDIVTIHVPLLESTYHLINEERLKLMKKSAILINTSRGAVVDTNALVKA 245
+ + + LL +D +++H+P T LI++E L K I++N +RG +VD AL A
Sbjct: 185 ELMSFDDLLARADFISVHLPKTPETAGLIDKEALAKTKPGVIIVNAARGGLVDEVALADA 244
Query: 246 LEEGWIAGAGLDVYEEEPLPKDHPLTKFDNVVLTPHIGASTVEAQERAGVEVAEKVVKIL 305
+ G + AGLDV+ EP D PL + VV+TPH+GAST EAQ+RAG +VAE V L
Sbjct: 245 VRSGHVRAAGLDVFATEPC-TDSPLFELSQVVVTPHLGASTAEAQDRAGTDVAESVRLAL 303
Query: 306 KG 307
G
Sbjct: 304 AG 305
>dbj|BAA99698.1| (AB025624) phosphoglycerate dehydrogenase [Arabidopsis thaliana]
Length = 588
Score = 245 bits (619), Expect = 5e-64
Identities = 129/304 (42%), Positives = 198/304 (64%), Gaps = 4/304 (1%)
Query: 6 VLVAAPLHEKAIQILKD-AGLEVIYEEYPEEDRLVELVKDVEAIIVRSKPKVTRKVIESA 64
+LV L + I +LK A ++ Y+ EE L + +A+IVRS KV R V ES+
Sbjct: 49 ILVTEKLGQAGIDLLKKYANVDCSYDLSLEE--LCTKISLCDALIVRSGTKVGRDVFESS 106
Query: 65 P-KLKVIARAGVGLDNIDVEAAKERGIEVVNAPAASSRSVAELAVALMFAVARKIAFADR 123
+LKV+ RAGVG+DN+D+ AA E G VVNAP A++ + AE +AL+ A+AR IA AD
Sbjct: 107 RGRLKVVGRAGVGIDNVDLAAATEYGCLVVNAPTANTVAAAEHGIALLTAMARNIAQADA 166
Query: 124 KMREGVWAKKQAMGIELEGKTLGIIGFGRIGYQVAKIARALGMNLLLYDPYPNEERAKEV 183
++ G W + + +G+ L GKTL ++GFG++G +VA+ AR LGM+++ +DPY +RA+ +
Sbjct: 167 SIKAGKWTRNKYVGVSLVGKTLAVLGFGKVGSEVARRARGLGMHVITHDPYAPADRARAI 226
Query: 184 GGKFVDLETLLRESDIVTIHVPLLESTYHLINEERLKLMKKSAILINTSRGAVVDTNALV 243
G + V E + +D +++H+PL +T ++N+ +MKK ++N +RG V+D AL+
Sbjct: 227 GVELVSFEVAISTADFISLHLPLTAATSKMMNDVTFAMMKKGVRIVNVARGGVIDEEALL 286
Query: 244 KALEEGWIAGAGLDVYEEEPLPKDHPLTKFDNVVLTPHIGASTVEAQERAGVEVAEKVVK 303
+AL+ G +A A LDV+ EP KD+ L ++V TPH+GAST+EAQE +EVAE V+
Sbjct: 287 RALDSGIVAQAALDVFTVEPPVKDNKLVLHESVTATPHLGASTMEAQEGVSIEVAEAVIG 346
Query: 304 ILKG 307
L+G
Sbjct: 347 ALRG 350
>pir||A72390 hypothetical protein TM0327 - Thermotoga maritima (strain MSB8)
>gi|4980828|gb|AAD35414.1|AE001714_5 (AE001714)
phosphoglycerate dehydrogenase, putative [Thermotoga
maritima]
Length = 327
Score = 242 bits (612), Expect = 3e-63
Identities = 139/296 (46%), Positives = 200/296 (66%), Gaps = 10/296 (3%)
Query: 14 EKAIQILKDAGLEVIYEEYPEEDRLVELVKDVEAIIVRSKPKVTRKVIESAPKLKVIARA 73
++ ++ L+ G E+I + + D ++K+V+A+IV + P VT +++E++ LK+IA+
Sbjct: 16 QEPVEFLRKEGFEIIRSDTIDPD----ILKEVDALIVGTHP-VTAEMVENS-SLKIIAKH 69
Query: 74 GVGLDNIDVEAAKERGIEVVNAPAASSRSVAELAVALMFAVARKIAFADRKM-REGVWAK 132
GVG+DNID+EAA ++GI V A+S SVAEL +A +FA++R + +A K+ E W
Sbjct: 70 GVGVDNIDLEAATKKGIPVTITAGANSLSVAELTIAFIFALSRGLVWAHNKLFLERRW-- 127
Query: 133 KQAMGIELEGKTLGIIGFGRIGYQVAKIARALGMNLLLYDPYPNEERAKEVGGKFVD-LE 191
+ +G E+ GKTLG++GFG IG +V K A LGMN+L+YDPY +++ + + VD LE
Sbjct: 128 EGTVGQEVSGKTLGVVGFGSIGREVVKKAVCLGMNVLVYDPYVSKDSVRLLEATPVDDLE 187
Query: 192 TLLRESDIVTIHVPLLESTYHLINEERLKLMKKSAILINTSRGAVVDTNALVKALEEGWI 251
LL+ESD V++HVPL EST ++I E L LMKKSA LINTSRG +VD ALVKAL+EG I
Sbjct: 188 QLLKESDFVSLHVPLNESTKNMIGERELSLMKKSAFLINTSRGELVDEEALVKALKEGRI 247
Query: 252 AGAGLDVYEEEPLPKDHPLTKFDNVVLTPHIGASTVEAQERAGVEVAEKVVKILKG 307
AGA LDV+ EEP + PL + N++ T HIGA T EA R + A+ +V KG
Sbjct: 248 AGAALDVFSEEPPDANSPLFECPNLITTAHIGAHTKEAIFRMNMMAAQSIVDFFKG 303
>dbj|BAB05321.1| (AP001512) D-3-phosphoglycerate dehydrogenase [Bacillus halodurans]
Length = 540
Score = 240 bits (606), Expect = 2e-62
Identities = 130/304 (42%), Positives = 193/304 (62%), Gaps = 6/304 (1%)
Query: 5 KVLVAAPLHEKAIQ-ILKDAGLEVIYEEYPEEDRLVELVKDVEAIIVRSKPKVTRKVIES 63
++LV+ + E+ + +L D +E + + + D L E +A++VRS VT +++E
Sbjct: 19 RILVSDAMSEQGLSPLLNDPRVECVQQNVADADDLHEY----DALLVRSATTVTEELMEK 74
Query: 64 APKLKVIARAGVGLDNIDVEAAKERGIEVVNAPAASSRSVAELAVALMFAVARKIAFADR 123
LK+IARAGVG+DNID++AA + GI VVNAP ++ S AE A++ ++ RKI A+
Sbjct: 75 MSSLKIIARAGVGVDNIDIDAATKHGIVVVNAPDGNTISTAEHTFAMICSLLRKIPQANA 134
Query: 124 KMREGVWAKKQAMGIELEGKTLGIIGFGRIGYQVAKIARALGMNLLLYDPYPNEERAKEV 183
++ G W +K G EL GKTLGIIGFGRIG Q+AK A+A M ++DP+ + RA+++
Sbjct: 135 SIKAGEWKRKAFQGTELRGKTLGIIGFGRIGSQIAKRAKAFEMTPYVFDPFLTKARAEKL 194
Query: 184 GGKFVDLETLLRESDIVTIHVPLLESTYHLINEERLKLMKKSAILINTSRGAVVDTNALV 243
G L+ +L+ +DI+T+H PL + T L+ + + KK LIN +RG ++D AL
Sbjct: 195 GVTVASLDDVLQVADIITVHTPLTKETKGLLGMKNIGKTKKGVFLINCARGGIIDEEALK 254
Query: 244 KALEEGWIAGAGLDVYEEEPLPKDHPLTKFDNVVLTPHIGASTVEAQERAGVEVAEKVVK 303
L EG IAGA LDV+EEEP+ D L FDNV+ TPHI AST EAQ +V+++V+
Sbjct: 255 HYLREGHIAGAALDVFEEEPV-ADEELLAFDNVIATPHIAASTKEAQLNVAEQVSQEVLH 313
Query: 304 ILKG 307
L+G
Sbjct: 314 FLEG 317
>pir||H70032 glycerate dehydrogenase homolog yvcT - Bacillus subtilis
>gi|2635981|emb|CAB15473.1| (Z99121) similar to
glycerate dehydrogenase [Bacillus subtilis]
Length = 325
Score = 239 bits (603), Expect = 3e-62
Identities = 126/314 (40%), Positives = 194/314 (61%), Gaps = 7/314 (2%)
Query: 1 MIEVKVLVAAPLHEKAIQILKD-AGLEVIYEEYPEEDRLVELVKDVEAIIVR--SKPKVT 57
M++ V + P+ E+ + + EV E+ D L E +K+ E ++ S P +
Sbjct: 1 MLKPFVFITKPIPEEIEAFIGEHCRYEVWQEDTLPSDVLFEKLKEAEGLLTSGTSGPSIN 60
Query: 58 RKVIESAPKLKVIARAGVGLDNIDVEAAKERGIEVVNAPAASSRSVAELAVALMFAVARK 117
R+++E APKLKV++ VG DN D+EA KERG+ + P +VA+LA +L+ + AR+
Sbjct: 61 RELLEHAPKLKVVSNQSVGYDNFDIEAMKERGVVGTHTPYTLDDTVADLAFSLILSSARR 120
Query: 118 IAFADRKMREGVWA---KKQAMGIELEGKTLGIIGFGRIGYQVAKIAR-ALGMNLLLYDP 173
+A DR +R G W ++ GI++ +TLGIIG GRIG Q A+ A+ M +L ++
Sbjct: 121 VAELDRFVRAGKWGTVEEEALFGIDVHHQTLGIIGMGRIGEQAARRAKFGFDMEVLYHNR 180
Query: 174 YPNEERAKEVGGKFVDLETLLRESDIVTIHVPLLESTYHLINEERLKLMKKSAILINTSR 233
+ +E +G K+ +L+TLL +SD + + PL + TYH+I E KLMK SAI +N SR
Sbjct: 181 HRKQETEDSIGVKYAELDTLLEQSDFILLITPLTDETYHMIGEREFKLMKNSAIFVNISR 240
Query: 234 GAVVDTNALVKALEEGWIAGAGLDVYEEEPLPKDHPLTKFDNVVLTPHIGASTVEAQERA 293
G VD AL++AL+EGWI GAGLDVYE+EP+ +D+PL + DNV L PHIG++T + +
Sbjct: 241 GKTVDEKALIRALQEGWIRGAGLDVYEKEPVTQDNPLLQLDNVTLLPHIGSATAKVRFNM 300
Query: 294 GVEVAEKVVKILKG 307
+ AE ++ ++G
Sbjct: 301 CKQAAENMLAAIQG 314
>emb|CAB08066.1| (Z94043) hypothetical protein [Bacillus subtilis]
Length = 288
Score = 234 bits (590), Expect = 1e-60
Identities = 118/276 (42%), Positives = 178/276 (63%), Gaps = 6/276 (2%)
Query: 38 LVELVKDVEAIIVR--SKPKVTRKVIESAPKLKVIARAGVGLDNIDVEAAKERGIEVVNA 95
L E +K+ E ++ S P + R+++E APKLKV++ VG DN D+EA KERG+ +
Sbjct: 2 LFEKLKEAEGLLTSGTSGPSINRELLEHAPKLKVVSNQSVGYDNFDIEAMKERGVVGTHT 61
Query: 96 PAASSRSVAELAVALMFAVARKIAFADRKMREGVWA---KKQAMGIELEGKTLGIIGFGR 152
P +VA+LA +L+ + AR++A DR +R G W ++ GI++ +TLGIIG GR
Sbjct: 62 PYTLDDTVADLAFSLILSSARRVAELDRFVRAGKWGTVEEEALFGIDVHHQTLGIIGMGR 121
Query: 153 IGYQVAKIAR-ALGMNLLLYDPYPNEERAKEVGGKFVDLETLLRESDIVTIHVPLLESTY 211
IG Q A+ A+ M +L ++ + +E +G K+ +L+TLL +SD + + PL + TY
Sbjct: 122 IGEQAARRAKFGFDMEVLYHNRHRKQETEDSIGVKYAELDTLLEQSDFILLITPLTDETY 181
Query: 212 HLINEERLKLMKKSAILINTSRGAVVDTNALVKALEEGWIAGAGLDVYEEEPLPKDHPLT 271
H+I E KLMK SAI +N SRG VD AL++AL+EGWI GAGLDVYE+EP+ +D+PL
Sbjct: 182 HMIGEREFKLMKNSAIFVNISRGKTVDEKALIRALQEGWIRGAGLDVYEKEPVTQDNPLL 241
Query: 272 KFDNVVLTPHIGASTVEAQERAGVEVAEKVVKILKG 307
+ DNV L PHIG++T + + + AE ++ ++G
Sbjct: 242 QLDNVTLLPHIGSATAKVRFNMCKQAAENMLAAIQG 277
>pir||T19602 hypothetical protein C31C9.2 - Caenorhabditis elegans
>gi|3874647|emb|CAB05694.1| (Z83219) contains similarity
to Pfam domain: PF00389 (D-isomer specific 2-hydroxyacid
dehydrogenases), Score=247.0, E-value=2.5e-101, N=1~cDNA
EST EMBL:T00729 comes from this gene~cDNA EST yk636a9.3
comes from this gene~cDNA EST yk636a9.5 comes from th>
Length = 322
Score = 232 bits (585), Expect = 5e-60
Identities = 124/304 (40%), Positives = 191/304 (62%), Gaps = 2/304 (0%)
Query: 5 KVLVAAPLHEKAIQILKDAGLEVIYEEYPEEDRLVELVKDVEAIIVRSKPKVTRKVIE-S 63
KVL+A + ++ + ILK G+EV + +D L+ + +A+IVRS K+T +++ S
Sbjct: 7 KVLIADDIEQECVDILKQNGIEVTVKTKQTKDELLVTLPQHDAVIVRSATKITAELLAAS 66
Query: 64 APKLKVIARAGVGLDNIDVEAAKERGIEVVNAPAASSRSVAELAVALMFAVARKIAFADR 123
A KLK++ RAG G+DNIDV AA I V+N P A+SRS AEL L+ +++R + A
Sbjct: 67 AGKLKLVGRAGTGVDNIDVPAASANKILVMNTPQANSRSAAELTCTLILSLSRHVPQAAA 126
Query: 124 KMREGVWAKKQAMGIELEGKTLGIIGFGRIGYQVAKIARALGMNLLLYDPYPNEERAKEV 183
M+ G WA+K MG E+ G+TL ++G GRIG +VA +A GM ++ +DP +E+A+
Sbjct: 127 SMKAGKWARKDFMGEEVYGRTLAVLGLGRIGSEVAVRLQAFGMKVIGFDPMVTKEQAEAK 186
Query: 184 GGKFVDLETLLRESDIVTIHVPLLESTYHLINEERLKLMKKSAILINTSRGAVVDTNALV 243
+ + LE + ++D +T+HVPL++ T +LIN+E L KK +IN +RG +V+ LV
Sbjct: 187 NIELLSLEQIWPQADYITVHVPLIKQTENLINKETLAKCKKGVRIINVARGGIVNEVDLV 246
Query: 244 KALEEGWIAGAGLDVYEEEPLPKDHPLTKFDNVVLTPHIGASTVEAQERAGVEVAEKVVK 303
++L G GA DV+E+EP P L V+ TPH+GAST++AQ R E+A+ +V+
Sbjct: 247 ESLNAGHAKGAAFDVFEQEP-PTFRELIDHPLVIATPHLGASTIDAQLRVASEIADNIVQ 305
Query: 304 ILKG 307
KG
Sbjct: 306 YNKG 309
>pir||A75414 D-3-phosphoglycerate dehydrogenase - Deinococcus radiodurans
(strain R1) >gi|6459038|gb|AAF10861.1|AE001976_4
(AE001976) D-3-phosphoglycerate dehydrogenase
[Deinococcus radiodurans]
Length = 544
Score = 231 bits (584), Expect = 6e-60
Identities = 123/290 (42%), Positives = 185/290 (63%), Gaps = 3/290 (1%)
Query: 20 LKDAGLEVIYEEYPEEDRLVELVKDVEAIIVRSKPKVTRKVIESA-PKLKVIARAGVGLD 78
L G ++ Y+ E + + + D +A+I RS+ KV R+++++A P+LKVI R GVG+D
Sbjct: 33 LDHEGFQIDYQGNLEREETLRRLPDYDALITRSRTKVDRELLDAAGPRLKVIGRGGVGVD 92
Query: 79 NIDVEAAKERGIEVVNAPAASSRSVAELAVALMFAVARKIAFADRKMREGVWAKKQAMGI 138
NID+E A RG+ V+NAP +++ S AELAV + A AR + +DRK R G W +K +G+
Sbjct: 93 NIDLEYASRRGLLVLNAPESNNVSAAELAVMHLMAAARGLTRSDRKTRAGEWDRK-FLGL 151
Query: 139 ELEGKTLGIIGFGRIGYQVAKIARALGMNLLLYDPYPNEERAKEVG-GKFVDLETLLRES 197
EL KTLGI+G GRIG VA A+ L MN++ YDPY E + + +G + L+ LL +
Sbjct: 152 ELTDKTLGIVGLGRIGSIVADRAQGLHMNVVAYDPYVPENKFERLGVQRAASLDELLGQV 211
Query: 198 DIVTIHVPLLESTYHLINEERLKLMKKSAILINTSRGAVVDTNALVKALEEGWIAGAGLD 257
D +T+H PL + T +I E L L+K+ AI++N +RG +++ ALV AL G + AG+D
Sbjct: 212 DALTVHTPLTDETRGMIGERELALLKRDAIVVNAARGGIIEEQALVNALHAGHLFAAGVD 271
Query: 258 VYEEEPLPKDHPLTKFDNVVLTPHIGASTVEAQERAGVEVAEKVVKILKG 307
V+ +EP +H N+ +T H+GA+T EAQER G E+ +V+ L G
Sbjct: 272 VFVDEPPTAEHIFLGAPNLGITAHLGANTREAQERVGAEIVSRVLDALHG 321
>gb|AAF19554.1|AC005761_2 (AC005761) D-3-phosphoglycerate dehydrogenase [Leishmania major]
Length = 407
Score = 228 bits (574), Expect = 9e-59
Identities = 129/296 (43%), Positives = 181/296 (60%), Gaps = 9/296 (3%)
Query: 16 AIQILKDAG--LEVIYEEYPEEDRLVELVKDVEAIIVRSKPKVTRKVIESAPKLKVIARA 73
A ++L+ G +E I P D L+E ++DV + +RSK +VT+ ++++APKL I
Sbjct: 21 AKELLESKGCIVEYIPNALPR-DTLLEKIRDVHFLGIRSKTQVTQAILDAAPKLLGIGCF 79
Query: 74 GVGLDNIDVEAAKERGIEVVNAPAASSRSVAELAVALMFAVARKIAFADRKMREGVWAKK 133
+G + +D++ A RG+ V N+P A++RSVAEL + + +++RK+ ++ GVW K
Sbjct: 80 CIGTNQVDLDYATTRGVAVFNSPFANTRSVAELVIGEIISLSRKMTQRSEEVHRGVWNKT 139
Query: 134 QAMGIELEGKTLGIIGFGRIGYQVAKIARALGMNLLLYDPYPNEERAKEVGGKFVDLETL 193
E+ GKT+GI+G+G IG QV +A ALGMN++ YD P A KF + L
Sbjct: 140 HVGCYEVRGKTVGIVGYGHIGSQVGVLAEALGMNVVFYDVLPT--LAIGNATKFTHINDL 197
Query: 194 LRESDIVTIHVPLLESTYHLINEERLKLMKKSAILINTSRGAVVDTNALVKALEEGWIAG 253
L SD VTIHVP + T +I EE+++LMKK + LIN SRG VVD AL KAL EG +AG
Sbjct: 198 LTFSDFVTIHVPETDVTKGMIGEEQIRLMKKGSYLINASRGTVVDLEALAKALREGHLAG 257
Query: 254 AGLDVYEEEPLPKDH----PLTKFDNVVLTPHIGASTVEAQERAGVEVAEKVVKIL 305
A +DVY EEP PL NV+LTPH+G ST EAQE GVEV + K +
Sbjct: 258 AAIDVYPEEPGSNKELHRTPLQGISNVILTPHVGGSTCEAQEAIGVEVGTALAKFV 313
>sp|P43885|SERA_HAEIN D-3-PHOSPHOGLYCERATE DEHYDROGENASE (PGDH) >gi|1075144|pir||C64070
phosphoglycerate dehydrogenase (EC 1.1.1.95) -
Haemophilus influenzae (strain Rd KW20)
>gi|1573443|gb|AAC22124.1| (U32729) D-3-phosphoglycerate
dehydrogenase (serA) [Haemophilus influenzae Rd]
Length = 410
Score = 228 bits (574), Expect = 9e-59
Identities = 131/312 (41%), Positives = 192/312 (60%), Gaps = 18/312 (5%)
Query: 3 EVKVLVAAPLHEKAIQILKDAGLEVI--YEEYPEEDRLVELVKDVEAIIVRSKPKVTRKV 60
++K ++ +H+ A+ L AG I Y++ + D L E +KDV I +RS+ +T ++
Sbjct: 11 KIKFVLFEGVHQSALDTLHAAGYTNIDYYKKALDGDELKEAIKDVHFIGLRSRTHLTAEM 70
Query: 61 IESAPKLKVIARAGVGLDNIDVEAAKERGIEVVNAPAASSRSVAELAVALMFAVARKIAF 120
IE+APKL + +G + +D+ AAK RGI V NAP +++RSVAEL + + + R +
Sbjct: 71 IEAAPKLIAVGCFCIGTNQVDLNAAKARGIPVFNAPFSNTRSVAELVLGEILLLMRNVPQ 130
Query: 121 ADRKMREGVWAKKQAMGIELEGKTLGIIGFGRIGYQVAKIARALGMNLLLYD-----PYP 175
A+ ++ GVW K E+ GK LGIIG+G IG Q++ IA +LGM++ YD P
Sbjct: 131 ANAEVHRGVWNKSATGSHEVRGKKLGIIGYGHIGSQLSIIAESLGMDVYFYDIENKLPLG 190
Query: 176 NEERAKEVGGKFVDLETLLRESDIVTIHVPLLESTYHLINEERLKLMKKSAILINTSRGA 235
N ++ + LE LL D+V++HVP L ST +L+N R+ +K+ AILIN +RG
Sbjct: 191 NAKQVR-------SLEELLSSCDVVSLHVPELPSTKNLMNVARIAQLKQGAILINAARGT 243
Query: 236 VVDTNALVKALEEGWIAGAGLDVYEEEPLPKDH----PLTKFDNVVLTPHIGASTVEAQE 291
VVD +AL +AL++G + GA +DV+ EP + PL +FDNV+LTPHIG ST EAQE
Sbjct: 244 VVDIDALAQALKDGKLQGAAIDVFPVEPASINEEFISPLREFDNVILTPHIGGSTAEAQE 303
Query: 292 RAGVEVAEKVVK 303
G EVA K VK
Sbjct: 304 NIGFEVAGKFVK 315
>sp|Q61753|SERA_MOUSE D-3-PHOSPHOGLYCERATE DEHYDROGENASE (PGDH) (A10)
>gi|986918|gb|AAB67986.1| (L21027) A10 [Mus musculus]
Length = 485
Score = 222 bits (560), Expect = 4e-57
Identities = 117/262 (44%), Positives = 164/262 (61%), Gaps = 1/262 (0%)
Query: 46 EAIIVRSKPKVTRKVIESAPKLKVIARAGVGLDNIDVEAAKERGIEVVNAPAASSRSVAE 105
E +IVRS KVT VI +A KL+V+ RA G+DN+D+E +GI V+N P +S S AE
Sbjct: 1 EGLIVRSATKVTADVINAAEKLQVVGRAVTGVDNVDLEPPTRKGILVMNTPNGNSLSAAE 60
Query: 106 LAVALMFAVARKIAFADRKMREGVWAKKQAMGIELEGKTLGIIGFGRIGYQVAKIARALG 165
L ++ +AR+I M++G W +K+ MG EL GKTLGI+G GRIG +VA ++ G
Sbjct: 61 LTCGMIMCLARQIPQTTASMKDGKWDRKKFMGTELNGKTLGILGLGRIGREVATRMQSFG 120
Query: 166 MNLLLYDPYPNEERAKEVGGKFVDLETLLRESDIVTIHVPLLESTYHLINEERLKLMKKS 225
M + YDP + E A G + + LE + D +T+H PLL ST L+N+ KK
Sbjct: 121 MKTVGYDPIISPEVAASFGVQQLPLEEIWPLCDFITVHTPLLPSTTGLLNDSTFAQCKKG 180
Query: 226 AILINTSRGAVVDTNALVKALEEGWIAGAGLDVYEEEPLPKDHPLTKFDNVVLTPHIGAS 285
++N +RG +VD AL++AL+ G AGA LDV+ EEP P+D L +NV+ PH+GAS
Sbjct: 181 VRVVNCARGGIVDEGALLRALQSGQCAGAALDVFTEEP-PRDRALVDHENVISCPHLGAS 239
Query: 286 TVEAQERAGVEVAEKVVKILKG 307
T EAQ R G E+A + V ++KG
Sbjct: 240 TKEAQSRCGEEIAVQFVDMVKG 261
>sp|P35136|SERA_BACSU D-3-PHOSPHOGLYCERATE DEHYDROGENASE (PGDH) >gi|7427681|pir||C69705
phosphoglycerate dehydrogenase (EC 1.1.1.95) serA -
Bacillus subtilis >gi|1146196|gb|AAC83943.1| (L47648)
phosphoglycerate dehydrogenase [Bacillus subtilis]
>gi|2634742|emb|CAB14239.1| (Z99116) phosphoglycerate
dehydrogenase [Bacillus subtilis]
Length = 525
Score = 221 bits (557), Expect = 9e-57
Identities = 121/305 (39%), Positives = 188/305 (60%), Gaps = 7/305 (2%)
Query: 5 KVLVAAPLHEKAIQILKDAG-LEVIYEEYPE-EDRLVELVKDVEAIIVRSKPKVTRKVIE 62
+VLV+ + +Q L ++ +E++ + + ED L +A++VRS KVT +
Sbjct: 3 RVLVSDKMSNDGLQPLIESDFIEIVQKNVADAEDEL----HTFDALLVRSATKVTEDLFN 58
Query: 63 SAPKLKVIARAGVGLDNIDVEAAKERGIEVVNAPAASSRSVAELAVALMFAVARKIAFAD 122
LK++ RAGVG+DNID++ A + G+ V+NAP ++ S AE A++ ++ R I A+
Sbjct: 59 KMTSLKIVGRAGVGVDNIDIDEATKHGVIVINAPNGNTISTAEHTFAMISSLMRHIPQAN 118
Query: 123 RKMREGVWAKKQAMGIELEGKTLGIIGFGRIGYQVAKIARALGMNLLLYDPYPNEERAKE 182
++ W + +G EL GKTLGI+G GRIG ++A+ A GM + ++DP+ EERAK+
Sbjct: 119 ISVKSREWNRTAYVGSELYGKTLGIVGLGRIGSEIAQRRGAFGMTVHVFDPFLTEERAKK 178
Query: 183 VGGKFVDLETLLRESDIVTIHVPLLESTYHLINEERLKLMKKSAILINTSRGAVVDTNAL 242
+G E +L +DI+T+H PL + T L+N+E + KK LIN +RG ++D AL
Sbjct: 179 IGVNSRTFEEVLESADIITVHTPLTKETKGLLNKETIAKTKKGVRLINCARGGIIDEAAL 238
Query: 243 VKALEEGWIAGAGLDVYEEEPLPKDHPLTKFDNVVLTPHIGASTVEAQERAGVEVAEKVV 302
++ALE G +AGA LDV+E EP P D+ L V+ TPH+GAST EAQ +V+E+V+
Sbjct: 239 LEALENGHVAGAALDVFEVEP-PVDNKLVDHPLVIATPHLGASTKEAQLNVAAQVSEEVL 297
Query: 303 KILKG 307
+ KG
Sbjct: 298 QFAKG 302
>gb|AAF53080.1| (AE003631) CG6287 gene product [Drosophila melanogaster]
Length = 332
Score = 220 bits (556), Expect = 1e-56
Identities = 123/304 (40%), Positives = 182/304 (59%), Gaps = 5/304 (1%)
Query: 5 KVLVAAPLHEKAIQILKDAGLEVIYEEYPEEDRLVELVKDVEAIIVRSKPKVTRKVIESA 64
KVLV + + +++L+ G++V Y+ + L + VK+ +A IVRS K+T +V+ +
Sbjct: 7 KVLVCDAVDKSCVELLEQHGIKVTYKLKLPVEELCQEVKNFDAAIVRSDTKITAEVLAAG 66
Query: 65 P-KLKVIARAGVGLDNIDVEAAKERGIEVVNAPAASSRSVAELAVALMFAVARKIAFADR 123
LKV+ RAG G+DNIDV AA + + V+N P +S S EL L+ ++AR + A +
Sbjct: 67 SGSLKVVGRAGAGVDNIDVPAATAQNVVVLNTPGGNSISACELTCILIGSLARPVVPAGQ 126
Query: 124 KMREGVWAKKQAMGIELEGKTLGIIGFGRIGYQVAKIARALGMNLLLYDPYPNEERAKEV 183
M+EG W +K G EL GKTL ++G GRIG +VA + GM ++ YDP E AK
Sbjct: 127 SMKEGRWDRKLYAGTELYGKTLAVLGLGRIGREVAIRMKTWGMRIIGYDPITTEAEAKAA 186
Query: 184 GGKFVDLETLLRESDIVTIHVPLLESTYHLINEERLKLMKKSAILINTSRGAVVDTNALV 243
G + + LE + +D +T+H PL+ +T +LI+ E L K+ ++N +RG ++D A++
Sbjct: 187 GIEKMTLEEIWPLADYITVHTPLIPATRNLISAETLAKCKQGVKVVNVARGGIIDEQAVL 246
Query: 244 KALEEGWIAGAGLDVYEEEPLPKD---HPLTKFDNVVLTPHIGASTVEAQERAGVEVAEK 300
LE G +AGA DVY EEP PK L VV TPH+GAST EAQ R VEVAE+
Sbjct: 247 DGLESGKVAGAAFDVYPEEP-PKSAVTKALISHPKVVATPHLGASTSEAQVRVAVEVAEQ 305
Query: 301 VVKI 304
+ +
Sbjct: 306 FIAL 309
>pir||C82072 D-3-phosphoglycerate dehydrogenase VC2481 [imported] - Vibrio
cholerae (group O1 strain N16961)
>gi|9657060|gb|AAF95623.1| (AE004317)
D-3-phosphoglycerate dehydrogenase [Vibrio cholerae]
Length = 409
Score = 220 bits (555), Expect = 1e-56
Identities = 127/308 (41%), Positives = 180/308 (58%), Gaps = 12/308 (3%)
Query: 4 VKVLVAAPLHEKAIQILKDAGLEVI--YEEYPEEDRLVELVKDVEAIIVRSKPKVTRKVI 61
+K+L+ LH ++++L+ AG I ++ EE L++ +KDV + +RS+ +T KVI
Sbjct: 11 IKILLLEGLHPSSVEVLQAAGYSNIEYHKGSLEEAELIKAIKDVHFVGIRSRSNLTEKVI 70
Query: 62 ESAPKLKVIARAGVGLDNIDVEAAKERGIEVVNAPAASSRSVAELAVALMFAVARKIAFA 121
+A KL I +G + +D+ AA +RGI V NAP +++RSVAEL + + + R I
Sbjct: 71 NAAEKLVAIGCFCIGTNQVDLNAAAKRGIPVFNAPFSNTRSVAELVLGEILLLLRGIPEK 130
Query: 122 DRKMREGVWAKKQAMGIELEGKTLGIIGFGRIGYQVAKIARALGMNLLLYDPYPNEERAK 181
+ G+W K E GK LGIIG+G IG Q+ IA LGM++ YD E
Sbjct: 131 NALAHRGIWKKSADNSYEARGKRLGIIGYGHIGTQLGIIAENLGMHVYFYD----IESKL 186
Query: 182 EVGG--KFVDLETLLRESDIVTIHVPLLESTYHLINEERLKLMKKSAILINTSRGAVVDT 239
+G + L LL + D++++HVP T +++ E MK AI IN +RG VVD
Sbjct: 187 SLGNATQVHTLSELLNKCDVISLHVPETAGTKNMMGAEEFARMKPGAIFINAARGTVVDI 246
Query: 240 NALVKALEEGWIAGAGLDVYEEEPL----PKDHPLTKFDNVVLTPHIGASTVEAQERAGV 295
AL ALE G IAGA +DV+ EEP P + PL KFDNV+LTPH+G ST EAQE G+
Sbjct: 247 PALCNALESGHIAGAAIDVFPEEPASNKEPFESPLMKFDNVILTPHVGGSTQEAQENIGI 306
Query: 296 EVAEKVVK 303
EVA K+ K
Sbjct: 307 EVAGKLAK 314
>gb|AAK41187.1| D-3-phosphoglycerate dehydrogenase (serA-1) [Sulfolobus
solfataricus]
Length = 326
Score = 220 bits (554), Expect = 2e-56
Identities = 122/308 (39%), Positives = 194/308 (62%), Gaps = 6/308 (1%)
Query: 2 IEVKVLVAAPLHEKAIQILKDAGLEVIYEEYPEEDRLVELVKDVEAIIVRSKPKVTRKVI 61
++ KVL+ P+ + I+ L++ GL V Y+ + L++++ + +IVRS+ KV +++I
Sbjct: 16 LDFKVLITDPVDQYMIRTLQNNGLIVDYKPEITREELLKIIDQYQVLIVRSRTKVDKEII 75
Query: 62 ESAPKLKVIARAGVGLDNIDVEAAKERGIEVVNAPAASSRSVAELAVALMFAVARKIAFA 121
LK+IARAG+GLDNID E A +R I++V AP AS+ S AEL + L+ A ARK+ +
Sbjct: 76 RYGVNLKIIARAGIGLDNIDTEEASKRNIKIVYAPGASTDSAAELTIGLLIAAARKLYDS 135
Query: 122 DRKMREGVWAKKQAMGIELEGKTLGIIGFGRIGYQVAKIARALGMNLLLYDPYPNEERAK 181
+ G++ K+ GIEL GKT+GI+GFGRIG +VAK+ +AL MN++ YD +E+A
Sbjct: 136 MNMAKGGIF--KKIEGIELAGKTIGIVGFGRIGTKVAKVCKALDMNVIAYDVINIKEKAN 193
Query: 182 EVGGKFVD-LETLLRESDIVTIHVPLLESTYHLINEERLKLMKKSAILINTSRGAVVDTN 240
VG + + LE LL+ SD++T HV + + ++N++ +K +AI+INTSR V+D
Sbjct: 194 IVGVRVAESLEELLKNSDVITFHVTVGKDAKPILNKDTFNYIKDNAIIINTSRAVVIDGK 253
Query: 241 ALVKALEEGWIAGAGLDVYEEEPLPKDH--PLTKFDNVVLTPHIGASTVEAQERAGVEVA 298
AL++ +++ + A DV EP +D L + + V++T HIGA T EAQ R V
Sbjct: 254 ALLEYIDKKHLTYA-TDVLWNEPPKEDWEIKLLRHERVIVTTHIGAQTKEAQHRVAVVTT 312
Query: 299 EKVVKILK 306
+ ++ LK
Sbjct: 313 DNLITALK 320
>sp|P87228|SERA_SCHPO PUTATIVE D-3-PHOSPHOGLYCERATE DEHYDROGENASE (PGDH)
>gi|7492817|pir||T41375 probable phosphoglycerate
dehydrogenase - fission yeast (Schizosaccharomyces
pombe) >gi|2213544|emb|CAB09778.1| (Z97052) putative
phosphoglycerate dehydrogenase [Schizosaccharomyces
pombe]
Length = 466
Score = 215 bits (543), Expect = 4e-55
Identities = 127/318 (39%), Positives = 191/318 (59%), Gaps = 19/318 (5%)
Query: 3 EVKVLVAAPLHEKAIQILKDAGLEVIY-EEYPEEDRLVELVKDVEAIIVRSKPKVTRKVI 61
++K+L+ +++ A+ LKD G +V + + ED LVE +K V AI +RSK ++TR+V+
Sbjct: 55 DIKILLLENVNQSALSNLKDEGYQVEFLKTSMSEDDLVEKIKGVHAIGIRSKTRLTRRVL 114
Query: 62 ESAPKLKVIARAGVGLDNIDVEAAKERGIEVVNAPAASSRSVAELAVALMFAVARKIAFA 121
E+A L VI +G + +D++ A ERGI V N+P A+SRSVAEL + + ++AR++
Sbjct: 115 EAADSLIVIGCFCIGTNQVDLDFAAERGIAVFNSPYANSRSVAELVIGYIISLARQVGDR 174
Query: 122 DRKMREGVWAKKQAMGIELEGKTLGIIGFGRIGYQVAKIARALGMNLLLYD--PYPNEER 179
++ G W K + E+ GKTLGIIG+G IG Q++ +A A+G++++ YD P
Sbjct: 175 SLELHRGEWNKVSSGCWEIRGKTLGIIGYGHIGSQLSVLAEAMGLHVVYYDILPIMPLGS 234
Query: 180 AKEVGGKFVDLETLLRESDIVTIHVPLLESTYHLINEERLKLMKKSAILINTSRGAVVDT 239
AK++ L LL +D V++HVP T ++I+ + MK+ + LIN SRG VVD
Sbjct: 235 AKQLS----SLPELLHRADFVSLHVPASPETKNMISSKEFAAMKEGSYLINASRGTVVDI 290
Query: 240 NALVKALEEGWIAGAGLDVYEEEPL--PKD----------HPLTKFDNVVLTPHIGASTV 287
ALV A + G IAGA +DVY EP KD LT N++LTPHIG ST
Sbjct: 291 PALVDASKSGKIAGAAIDVYPSEPAGNGKDKFVDSLNSWTSELTHCKNIILTPHIGGSTE 350
Query: 288 EAQERAGVEVAEKVVKIL 305
EAQ G+EV+E + + +
Sbjct: 351 EAQYNIGIEVSEALTRYI 368
>dbj|BAB12215.1| (AB032549) d-3-phosphoglycerate dehydrogenase [Microcystis
aeruginosa]
Length = 337
Score = 215 bits (542), Expect = 5e-55
Identities = 125/306 (40%), Positives = 184/306 (59%), Gaps = 3/306 (0%)
Query: 5 KVLVAAPLHEKAIQILKDAGLEVIYEEYPEEDRLVELVKDVEAIIVRSKPKVTRKVIESA 64
+VL+ ++++A Q L + + P + + E +++V + VR K+ I A
Sbjct: 17 RVLLIGKMYDEAGQKLLEESTNIEILSNPTLEEINEAIQEVSGVFVRYPNKLEASSIRLA 76
Query: 65 PKLKVIARAGVGLDNIDVEAAKERGIEVVNAPAASSRSVAELAVALMFAVARKIAFADRK 124
+LKVI+ +G G D+ID+ AA E+G+ VVN P S+ SVAE ++++ A+A+K+ F D
Sbjct: 77 KQLKVISTSGFGTDSIDIMAATEQGVIVVNNPGMSTTSVAEHTLSMILALAKKLPFLDHC 136
Query: 125 MREGVWA-KKQAMGIELEGKTLGIIGFGRIGYQVA-KIARALGMNLLLYDPYPNEERAKE 182
+++G + + Q I+LE KTLGI+G GRIG VA K ALGM +L YDPY +A+
Sbjct: 137 VKKGNYLIRNQMQPIQLENKTLGIVGLGRIGTLVAHKCNLALGMRVLAYDPYVPASKAET 196
Query: 183 VGGKFV-DLETLLRESDIVTIHVPLLESTYHLINEERLKLMKKSAILINTSRGAVVDTNA 241
VG +V DL+ LL ESD V++H L T + N K MK +A LINTSRG VV
Sbjct: 197 VGATWVKDLDVLLAESDFVSLHTELTSETREMFNISVFKKMKPTAFLINTSRGKVVCEKD 256
Query: 242 LVKALEEGWIAGAGLDVYEEEPLPKDHPLTKFDNVVLTPHIGASTVEAQERAGVEVAEKV 301
L AL + IAG LDV+E EP D+PL F+NV+L+PH+ T EA A V A ++
Sbjct: 257 LGIALNQKLIAGCALDVFEPEPPALDNPLYNFENVILSPHLAGVTPEASLAAAVSAANQI 316
Query: 302 VKILKG 307
+++L+G
Sbjct: 317 LQVLQG 322
>sp|P08328|SERA_ECOLI D-3-PHOSPHOGLYCERATE DEHYDROGENASE (PGDH) >gi|65956|pir||DEECPG
phosphoglycerate dehydrogenase (EC 1.1.1.95) -
Escherichia coli >gi|459755|gb|AAA24625.1| (L29397)
phosphoglycerate dehydrogenase [Escherichia coli]
>gi|882442|gb|AAA69080.1| (U28377) D-3-phosphoglycerate
dehydrogenase [Escherichia coli]
>gi|1789279|gb|AAC75950.1| (AE000374)
D-3-phosphoglycerate dehydrogenase [Escherichia coli
K12]
Length = 410
Score = 214 bits (540), Expect = 9e-55
Identities = 126/312 (40%), Positives = 185/312 (58%), Gaps = 18/312 (5%)
Query: 3 EVKVLVAAPLHEKAIQILKDAGLEVI--YEEYPEEDRLVELVKDVEAIIVRSKPKVTRKV 60
++K L+ +H+KA++ L+ AG I ++ ++++L E ++D I +RS+ +T V
Sbjct: 10 KIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDV 69
Query: 61 IESAPKLKVIARAGVGLDNIDVEAAKERGIEVVNAPAASSRSVAELAVALMFAVARKIAF 120
I +A KL I +G + +D++AA +RGI V NAP +++RSVAEL + + + R +
Sbjct: 70 INAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPE 129
Query: 121 ADRKMREGVWAKKQAMGIELEGKTLGIIGFGRIGYQVAKIARALGMNLLLYD-----PYP 175
A+ K GVW K A E GK LGIIG+G IG Q+ +A +LGM + YD P
Sbjct: 130 ANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLG 189
Query: 176 NEERAKEVGGKFVDLETLLRESDIVTIHVPLLESTYHLINEERLKLMKKSAILINTSRGA 235
N + + L LL SD+V++HVP ST +++ + + LMK ++LIN SRG
Sbjct: 190 NATQVQH-------LSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGT 242
Query: 236 VVDTNALVKALEEGWIAGAGLDVYEEEPL----PKDHPLTKFDNVVLTPHIGASTVEAQE 291
VVD AL AL +AGA +DV+ EP P PL +FDNV+LTPHIG ST EAQE
Sbjct: 243 VVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQE 302
Query: 292 RAGVEVAEKVVK 303
G+EVA K++K
Sbjct: 303 NIGLEVAGKLIK 314
>pdb|1PSD|A Chain A, D-3-Phosphoglycerate Dehydrogenase (Phosphoglycerate
Dehydrogenase) (E.C.1.1.1.95) >gi|1127237|pdb|1PSD|B
Chain B, D-3-Phosphoglycerate Dehydrogenase
(Phosphoglycerate Dehydrogenase) (E.C.1.1.1.95)
Length = 409
Score = 214 bits (540), Expect = 9e-55
Identities = 126/312 (40%), Positives = 185/312 (58%), Gaps = 18/312 (5%)
Query: 3 EVKVLVAAPLHEKAIQILKDAGLEVI--YEEYPEEDRLVELVKDVEAIIVRSKPKVTRKV 60
++K L+ +H+KA++ L+ AG I ++ ++++L E ++D I +RS+ +T V
Sbjct: 9 KIKFLLVEGVHQKALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDV 68
Query: 61 IESAPKLKVIARAGVGLDNIDVEAAKERGIEVVNAPAASSRSVAELAVALMFAVARKIAF 120
I +A KL I +G + +D++AA +RGI V NAP +++RSVAEL + + + R +
Sbjct: 69 INAAEKLVAIGCFCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPE 128
Query: 121 ADRKMREGVWAKKQAMGIELEGKTLGIIGFGRIGYQVAKIARALGMNLLLYD-----PYP 175
A+ K GVW K A E GK LGIIG+G IG Q+ +A +LGM + YD P
Sbjct: 129 ANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLG 188
Query: 176 NEERAKEVGGKFVDLETLLRESDIVTIHVPLLESTYHLINEERLKLMKKSAILINTSRGA 235
N + + L LL SD+V++HVP ST +++ + + LMK ++LIN SRG
Sbjct: 189 NATQVQH-------LSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGT 241
Query: 236 VVDTNALVKALEEGWIAGAGLDVYEEEPL----PKDHPLTKFDNVVLTPHIGASTVEAQE 291
VVD AL AL +AGA +DV+ EP P PL +FDNV+LTPHIG ST EAQE
Sbjct: 242 VVDIPALCDALASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQE 301
Query: 292 RAGVEVAEKVVK 303
G+EVA K++K
Sbjct: 302 NIGLEVAGKLIK 313
>pir||C83607 D-3-phosphoglycerate dehydrogenase PA0316 [imported] - Pseudomonas
aeruginosa (strain PAO1)
>gi|9946162|gb|AAG03705.1|AE004469_10 (AE004469)
D-3-phosphoglycerate dehydrogenase [Pseudomonas
aeruginosa]
Length = 409
Score = 211 bits (532), Expect = 7e-54
Identities = 125/309 (40%), Positives = 177/309 (56%), Gaps = 12/309 (3%)
Query: 3 EVKVLVAAPLHEKAIQILKDAGLEVIYEEYPEE----DRLVELVKDVEAIIVRSKPKVTR 58
++K L+ +H+ A+ LK AG I EY + D L E + D I +RS+ ++T
Sbjct: 10 KIKFLLLEGVHQNAVDTLKAAGYTNI--EYLKTALSGDELKERIADAHFIGIRSRTQLTE 67
Query: 59 KVIESAPKLKVIARAGVGLDNIDVEAAKERGIEVVNAPAASSRSVAELAVALMFAVARKI 118
+V + A KL + +G + +D+ AA+ERGI V NAP +++RSVAEL +A + R I
Sbjct: 68 EVFDCAKKLIAVGCFCIGTNQVDLNAARERGIAVFNAPYSNTRSVAELVLAEAILLLRGI 127
Query: 119 AFADRKMREGVWAKKQAMGIELEGKTLGIIGFGRIGYQVAKIARALGMNLLLYDPYPNEE 178
+ G W K A E+ GK LGI+G+G IG Q++ +A ALGM + YD
Sbjct: 128 PEKNASCHRGGWIKSAANSFEIRGKKLGIVGYGSIGTQLSVLAEALGMQVFFYDTVTKLP 187
Query: 179 RAKEVGGKFVDLETLLRESDIVTIHVPLLESTYHLINEERLKLMKKSAILINTSRGAVVD 238
V + L LL SDIV++HVP L ST +I E+ ++ MKK ILIN +RG VV+
Sbjct: 188 LGNAV--QIGSLHELLGMSDIVSLHVPELPSTQWMIGEKEIRAMKKGGILINAARGTVVE 245
Query: 239 TNALVKALEEGWIAGAGLDVYEEEPLPKDH----PLTKFDNVVLTPHIGASTVEAQERAG 294
+ L A+++ + GA +DV+ EP D PL D V+LTPHIG ST EAQ G
Sbjct: 246 LDHLAAAIKDEHLIGAAIDVFPVEPKSNDEEFASPLRGLDRVILTPHIGGSTAEAQANIG 305
Query: 295 VEVAEKVVK 303
+EVAEK+VK
Sbjct: 306 LEVAEKLVK 314
>gb|AAF00955.1|AF183408_3 (AF183408) McyI [Microcystis aeruginosa]
Length = 337
Score = 210 bits (528), Expect = 2e-53
Identities = 121/306 (39%), Positives = 181/306 (58%), Gaps = 3/306 (0%)
Query: 5 KVLVAAPLHEKAIQILKDAGLEVIYEEYPEEDRLVELVKDVEAIIVRSKPKVTRKVIESA 64
+VL+ ++++A Q L + + P + + E +++V + VR + I A
Sbjct: 17 RVLLIGKMYDEAGQKLLEESTNIEILSNPTPEEINEAIQEVSGVFVRYPNNLEASSIRLA 76
Query: 65 PKLKVIARAGVGLDNIDVEAAKERGIEVVNAPAASSRSVAELAVALMFAVARKIAFADRK 124
LKVI+ +G G D+ID+ AA E+G+ VVN P S+ +VAE ++++ A+A+K+ F D
Sbjct: 77 KHLKVISTSGFGTDSIDIMAATEQGVIVVNNPGMSTTAVAEHTLSMILALAKKLPFLDHC 136
Query: 125 MREGVWA-KKQAMGIELEGKTLGIIGFGRIGYQVA-KIARALGMNLLLYDPYPNEERAKE 182
+++G + + Q I+LE KTLGI+G GRIG VA K ALGM +L YDPY +A+
Sbjct: 137 VKKGNYLIRNQMQPIQLENKTLGIVGLGRIGTLVAHKCNLALGMRVLAYDPYVPASKAET 196
Query: 183 VGGKFV-DLETLLRESDIVTIHVPLLESTYHLINEERLKLMKKSAILINTSRGAVVDTNA 241
VG + DL+ LL ESD V++H L T + N K MK +A LINTSRG VV
Sbjct: 197 VGATLLKDLDVLLAESDFVSLHTELTSETREMFNISVFKKMKPTAFLINTSRGKVVCEKD 256
Query: 242 LVKALEEGWIAGAGLDVYEEEPLPKDHPLTKFDNVVLTPHIGASTVEAQERAGVEVAEKV 301
L AL + I+G LDV+E EP D+PL F+NV+L+PH+ T EA A V A ++
Sbjct: 257 LGIALNQKLISGCALDVFEPEPPALDNPLYNFENVILSPHLAGVTPEASLAAAVSAANQI 316
Query: 302 VKILKG 307
+++L+G
Sbjct: 317 LQVLRG 322
>gi|6320925 3-phosphoglycerate dehydrogenase; Ser3p [Saccharomyces cerevisiae]
>gi|731484|sp|P40054|SERA_YEAST D-3-PHOSPHOGLYCERATE
DEHYDROGENASE 1 (PGDH) >gi|1077676|pir||S50584 probable
phosphoglycerate dehydrogenase (EC 1.1.1.95) YER081w -
yeast (Saccharomyces cerevisiae)
>gi|603319|gb|AAB64636.1| (U18839) Yer081wp
[Saccharomyces cerevisiae]
Length = 469
Score = 206 bits (519), Expect = 2e-52
Identities = 119/316 (37%), Positives = 182/316 (56%), Gaps = 15/316 (4%)
Query: 3 EVKVLVAAPLHEKAIQILKDAGLEV-IYEEYPEEDRLVELVKDVEAIIVRSKPKVTRKVI 61
++K+L+ +++ AI I ++ G +V Y+ E+ L+E +KDV AI +RSK ++T V+
Sbjct: 58 DMKILLLENVNQTAITIFEEQGYQVEFYKSSLPEEELIEKIKDVHAIGIRSKTRLTSNVL 117
Query: 62 ESAPKLKVIARAGVGLDNIDVEAAKERGIEVVNAPAASSRSVAELAVALMFAVARKIAFA 121
+ A L I +G + +D++ A RGI V N+P ++SRSVAEL +A + ++AR++
Sbjct: 118 QHAKNLVCIGCFCIGTNQVDLDYATSRGIAVFNSPFSNSRSVAELVIAEIISLARQLGDR 177
Query: 122 DRKMREGVWAKKQAMGIELEGKTLGIIGFGRIGYQVAKIARALGMNLLLYDPYPNEERAK 181
++ G W K A E+ GKTLGIIG+G IG Q++ +A A+G+++L YD A
Sbjct: 178 SIELHTGTWNKVAARCWEVRGKTLGIIGYGHIGSQLSVLAEAMGLHVLYYDIV--TIMAL 235
Query: 182 EVGGKFVDLETLLRESDIVTIHVPLLESTYHLINEERLKLMKKSAILINTSRGAVVDTNA 241
+ L+ LL +SD VT+HVP T +++ + MK A +IN SRG VVD +
Sbjct: 236 GTARQVSTLDELLNKSDFVTLHVPATPETEKMLSAPQFAAMKDGAYVINASRGTVVDIPS 295
Query: 242 LVKALEEGWIAGAGLDVYEEEPLPKDH------------PLTKFDNVVLTPHIGASTVEA 289
L++A++ IAGA LDVY EP L N++LTPHIG ST EA
Sbjct: 296 LIQAVKANKIAGAALDVYPHEPAKNGEGSFNDELNSWTSELVSLPNIILTPHIGGSTEEA 355
Query: 290 QERAGVEVAEKVVKIL 305
Q G+EVA + K +
Sbjct: 356 QSSIGIEVATALSKYI 371
>pir||D75067 probable dehydrogenase PAB1008 - Pyrococcus abyssi (strain Orsay)
>gi|5458946|emb|CAB50433.1| (AJ248287) hypothetical
DEHYDROGENASE [Pyrococcus abyssi]
Length = 333
Score = 206 bits (519), Expect = 2e-52
Identities = 110/289 (38%), Positives = 173/289 (59%), Gaps = 9/289 (3%)
Query: 26 EVIYEEYPEEDRLVELVKDVEAIIVRSKPKVTRKVIESAPKLKVIARAGVGLDNIDVEAA 85
+V+ + YP E+ L E++ +++ II+ ++T+ ++E A +LKVI+ G D++DVE A
Sbjct: 24 DVVLKPYPSEEELKEIIPELDGIIIAPVTRITKDILERAERLKVISCQSAGYDHVDVEEA 83
Query: 86 KERGIEVVNAPAASSRSVAELAVALMFAVARKIAFADRKMREGVWAKKQAMGIE------ 139
+RGI V S +VAE A+ L+ ++ RKI +AD +REG W + E
Sbjct: 84 TKRGIYVTKVSGLLSEAVAEFALGLLISLMRKIHYADSFIREGKWESHTFVWREFKEVET 143
Query: 140 LEGKTLGIIGFGRIGYQVAKIARALGMNLLLYDPYPNEERAKEVGGKFVDLETLLRESDI 199
L GK +GI+G G IG +A+ + G + + + E+ +EV K++DL+ LL E DI
Sbjct: 144 LYGKEVGIVGMGAIGKAIARRLKPFGCEIYYWSRHRKEDIEREVNAKYLDLDELLEEVDI 203
Query: 200 VTIHVPLLESTYHLINEERLKLMKKSAILINTSRGAVVDTNALVKALEEGWIAGAGLDVY 259
V + +PL + TYH+INEER+K + + L+N RGA++D ALVKA++EG + G DV+
Sbjct: 204 VILALPLTKETYHIINEERVKKL-EGKYLVNIGRGALIDEKALVKAIKEGKLKGFATDVF 262
Query: 260 EEEPLPKDHPLTKFD-NVVLTPHIGASTVEAQERAGVEVAEKVVKILKG 307
EEEP+ K+H L +F VLTPH + E G E ++K+L+G
Sbjct: 263 EEEPV-KEHELFRFKWETVLTPHYAGLGKDVLEDMGFRAVENLLKVLRG 310
>gi|6322116 3-phosphoglycerate dehydrogenase; Ser33p [Saccharomyces cerevisiae]
>gi|731830|sp|P40510|SE33_YEAST D-3-PHOSPHOGLYCERATE
DEHYDROGENASE 2 (PGDH) >gi|626300|pir||S48370 probable
phosphoglycerate dehydrogenase (EC 1.1.1.95) YIL074c -
yeast (Saccharomyces cerevisiae)
>gi|556873|emb|CAA86096.1| (Z37997) orf, len: 469, CAI:
0.23, similar to SERA_ECOLI P08328 D-3-PHOSPHOGLYCERATE
DEHYDROGENASE [Saccharomyces cerevisiae]
Length = 469
Score = 205 bits (516), Expect = 6e-52
Identities = 118/316 (37%), Positives = 181/316 (56%), Gaps = 15/316 (4%)
Query: 3 EVKVLVAAPLHEKAIQILKDAGLEVIYEEYP-EEDRLVELVKDVEAIIVRSKPKVTRKVI 61
++ +L+ ++ AI+I KD G +V + + ED L+E +KDV AI +RSK ++T K++
Sbjct: 58 DMNILLLENVNATAIKIFKDQGYQVEFHKSSLPEDELIEKIKDVHAIGIRSKTRLTEKIL 117
Query: 62 ESAPKLKVIARAGVGLDNIDVEAAKERGIEVVNAPAASSRSVAELAVALMFAVARKIAFA 121
+ A L I +G + +D++ A +GI V N+P ++SRSVAEL + + ++AR++
Sbjct: 118 QHARNLVCIGCFCIGTNQVDLKYAASKGIAVFNSPFSNSRSVAELVIGEIISLARQLGDR 177
Query: 122 DRKMREGVWAKKQAMGIELEGKTLGIIGFGRIGYQVAKIARALGMNLLLYDPYPNEERAK 181
++ G W K A E+ GKTLGIIG+G IG Q++ +A A+G+++L YD A
Sbjct: 178 SIELHTGTWNKVAARCWEVRGKTLGIIGYGHIGSQLSVLAEAMGLHVLYYDIV--TIMAL 235
Query: 182 EVGGKFVDLETLLRESDIVTIHVPLLESTYHLINEERLKLMKKSAILINTSRGAVVDTNA 241
+ L+ LL +SD VT+HVP T +++ + MK A +IN SRG VVD +
Sbjct: 236 GTARQVSTLDELLNKSDFVTLHVPATPETEKMLSAPQFAAMKDGAYVINASRGTVVDIPS 295
Query: 242 LVKALEEGWIAGAGLDVYEEEPLPKDH------------PLTKFDNVVLTPHIGASTVEA 289
L++A++ IAGA LDVY EP L N++LTPHIG ST EA
Sbjct: 296 LIQAVKANKIAGAALDVYPHEPAKNGEGSFNDELNSWTSELVSLPNIILTPHIGGSTEEA 355
Query: 290 QERAGVEVAEKVVKIL 305
Q G+EVA + K +
Sbjct: 356 QSSIGIEVATALSKYI 371
>pir||C81362 phosphoglycerate dehydrogenase (EC 1.1.1.95) Cj0891c [imported] -
Campylobacter jejuni (strain NCTC 11168)
>gi|6968329|emb|CAB73149.1| (AL139076)
D-3-phosphoglycerate dehydrogenase [Campylobacter
jejuni]
Length = 527
Score = 203 bits (511), Expect = 2e-51
Identities = 110/306 (35%), Positives = 181/306 (58%), Gaps = 4/306 (1%)
Query: 5 KVLVAAPLHEKAIQILKDA-GLEVIYEEYPEEDRLVELVKDVEAIIVRSKPKVTRKVIES 63
K++V + +K + IL+ A +E+I +D L++++ D+E I RS V +
Sbjct: 4 KIIVCDAILDKGVDILRKAEDIELIEAAKFPKDELMQMLSDIEVAITRSSTDVDVNFLNH 63
Query: 64 APKLKVIARAGVGLDNIDVEAAKERGIEVVNAPAASSRSVAELAVALMFAVARKIAFADR 123
A KLK + RAGVG+DN+D+ +RG+ V+N P A++ + EL +A + AR A
Sbjct: 64 AKKLKALVRAGVGVDNVDIPECSKRGVIVMNVPTANTIAAVELTMAHLLTSARSFVNAHN 123
Query: 124 KMR-EGVWAKKQAMGIELEGKTLGIIGFGRIGYQVAKIARALGMNLLLYDPYPNEERAKE 182
++ E W +++ GIEL KTLG+IGFG IG +VA A+A GM +L YDPY + + +
Sbjct: 124 FLKIERKWEREKWYGIELMNKTLGVIGFGNIGSRVAIRAKAFGMKILAYDPYISASKITD 183
Query: 183 VG-GKFVDLETLLRESDIVTIHVPLLESTYHLINEERLKLMKKSAILINTSRGAVVDTNA 241
+ + +L+ +L +SD +TIH P + T +I ++ + MK LIN +RG + A
Sbjct: 184 LDMEQAKNLDEILEKSDFITIHTPKTKETNGMIGKQEIAKMKDGIRLINCARGGLYTEEA 243
Query: 242 LVKALEEGWIAGAGLDVYEEEPLPKDHPLTKFDNVVLTPHIGASTVEAQERAGVEVAEKV 301
L + L+ G IA G+DV+++EP +HPL F+N+ +T H+GA+T+E+Q+ E E+
Sbjct: 244 LYEGLKSGKIAWLGIDVFDKEP-ATNHPLLDFENISVTSHLGANTLESQDNIAREACEQA 302
Query: 302 VKILKG 307
+ +G
Sbjct: 303 LSAARG 308
>gi|11499368 2-hydroxyacid dehydrogenase, putative [Archaeoglobus fulgidus]
>gi|7431350|pir||B69472 2-hydroxyacid dehydrogenase
homolog - Archaeoglobus fulgidus
>gi|2648765|gb|AAB89467.1| (AE000979) 2-hydroxyacid
dehydrogenase, putative [Archaeoglobus fulgidus]
Length = 323
Score = 202 bits (509), Expect = 4e-51
Identities = 122/307 (39%), Positives = 181/307 (58%), Gaps = 9/307 (2%)
Query: 8 VAAPLHEKAIQILKDAGLEVIYEEYPEEDRLVELVKDVEAII--VRSKPKVTRKVIESAP 65
+A PL + I + +EV+ +E R++E V+D + +I K +T +++ +
Sbjct: 10 IAEPLLKGLIGSVYSGEVEVVVIGEYDERRILEAVRDADIVIGDYTFKIPITEEMMRAME 69
Query: 66 KLKVIARAGVGLDNIDVEAAKERGIEVVNAPAASSRSVAELAVALMFAVARKIAFADRKM 125
K+K+I + G +NIDVEAAK+ I V N ++ SVAE V A+ R++ +A +
Sbjct: 70 KVKLIQQPSTGYNNIDVEAAKKLSITVANVGGVNALSVAEHTVMFALALLRRLIYAHNSV 129
Query: 126 REGVWAKKQAMGI---ELEGKTLGIIGFGRIGYQVAKIARALGMNLLLYDPYPNEERAKE 182
G W + + + EL GKT GIIG G G +V K + G+ ++ +D E+ +E
Sbjct: 130 LSGRWEQDEMANLGVYELHGKTWGIIGMGAQGREVTKRLQGWGVKIIYHDVRRAED-IEE 188
Query: 183 VGGKFVDLETLLRESDIVTIHVPLLESTYHLINEERLKLMKKSAILINTSRGAVVDTNAL 242
G +F D + LLRE+DIV++HVPL E T +I E LK+MK SAILIN +RG VVD NAL
Sbjct: 189 YGVEFRDFDALLREADIVSLHVPLTEETRGMIGERELKMMKNSAILINVARGEVVDENAL 248
Query: 243 VKALEEGWIAGAGLDVYEEEPLPKDHPL--TKFDNVVLTPHIGASTVEAQERAGVEVAEK 300
V+A++E WIAGA LDV+ +EP P+ L K NV+ TPHI +T EA+ R E E
Sbjct: 249 VRAIKERWIAGAALDVFAKEP-PEGSELLELKSHNVIFTPHIAGATNEARLRIIREAMEN 307
Query: 301 VVKILKG 307
+ + L+G
Sbjct: 308 IGRALRG 314
>gb|AAC46259.1| (AF006000) D-3-phosphoglycerate dehydrogenase homolog [Bordetella
pertussis]
Length = 399
Score = 202 bits (508), Expect = 5e-51
Identities = 119/313 (38%), Positives = 177/313 (56%), Gaps = 18/313 (5%)
Query: 5 KVLVAAPLHEKAIQILKDAGLE--VIYEEYPEEDRLVELVKDVEAIIVRSKPKVTRKVIE 62
++++ +H A + AG V + L E ++ E + +RS+ + ++
Sbjct: 3 QIVLFENIHPSARAVFSAAGYTDIVAHAAALPSGELREALRGAEVVGIRSRTHLDADLLA 62
Query: 63 SAPKLKVIARAGVGLDNIDVEAAKERGIEVVNAPAASSRSVAELAVALMFAVARKIAFAD 122
+ P L+V+ +G + +D++AA RG+ V NAP +++RSVAEL + + R+I +
Sbjct: 63 ANPDLRVVGCFCIGTNQVDLDAAMMRGVPVFNAPFSNTRSVAELVLGETILLLRRIPEKN 122
Query: 123 RKMREGVWAKKQAMGIELEGKTLGIIGFGRIGYQVAKIARALGMNLLLYD-----PYPNE 177
++ G W K A E GKTLGI+G+G IG Q++ +A A+GM ++ +D P N
Sbjct: 123 ARVHLGHWDKSAAGAYEARGKTLGIVGYGNIGSQISTLAEAIGMRVVFFDVEAKLPLGNA 182
Query: 178 ERAKEVGGKFVDLETLLRESDIVTIHVPLLESTYHLINEERLKLMKKSAILINTSRGAVV 237
A L LL ++D+VT+HVP +ST +++N + L MK+ AILIN SRG VV
Sbjct: 183 RAAG-------SLAELLEQADVVTLHVPGGKSTQNIVNADTLARMKRGAILINASRGTVV 235
Query: 238 DTNALVKALEEGWIAGAGLDVYEEEPLPKDHPLTK----FDNVVLTPHIGASTVEAQERA 293
D AL AL G +AGA LDV+ EP D PL NVVLTPHIG ST E+QE
Sbjct: 236 DIQALHDALASGHLAGAALDVFPTEPKSADEPLASPLIGMPNVVLTPHIGGSTQESQENI 295
Query: 294 GVEVAEKVVKILK 306
G EVAEK+V+ L+
Sbjct: 296 GREVAEKLVRFLQ 308
>emb|CAB61802.1| (AL133236) putative dehydrogenase [Streptomyces coelicolor A3(2)]
Length = 344
Score = 200 bits (504), Expect = 1e-50
Identities = 112/290 (38%), Positives = 168/290 (57%), Gaps = 2/290 (0%)
Query: 19 ILKDAGLEVIYEEYPEEDRLVELVKDVEAIIVRSKPKVTRKVIESAPKLKVIARAGVGLD 78
++ AG +++ + + D +V +AI+V+ +T +V++ P+LKVI R GVG+D
Sbjct: 33 VVTSAGGQLLVTQSRDADTMVVNCAGADAIVVQYAA-ITEQVMDRLPRLKVIGRYGVGVD 91
Query: 79 NIDVEAAKERGIEVVNAPAASSRSVAELAVALMFAVARKIAFADRKMREGVWAKKQAMGI 138
++DVEAA RGI V N P + +V++ A+ L +VAR I DR +R G + +
Sbjct: 92 SVDVEAATRRGILVCNVPDYGTEAVSDHAIGLALSVARGIPRLDRGVRAGSFDLPAVRPL 151
Query: 139 ELEG-KTLGIIGFGRIGYQVAKIARALGMNLLLYDPYPNEERAKEVGGKFVDLETLLRES 197
G + G++G G IG A+ A LG +++ YD + + G + V L LL +
Sbjct: 152 YQVGQRVFGVVGMGLIGAATARKAAGLGYDVIAYDSAADPDAQTFRGFRSVGLHELLERA 211
Query: 198 DIVTIHVPLLESTYHLINEERLKLMKKSAILINTSRGAVVDTNALVKALEEGWIAGAGLD 257
+V++H PL E T L+ + M+ AI++NTSRG V+DT ALV AL+ G +AGAG+D
Sbjct: 212 QVVSVHTPLTEQTRGLLGADAFARMRPDAIVVNTSRGGVIDTGALVDALKRGAVAGAGID 271
Query: 258 VYEEEPLPKDHPLTKFDNVVLTPHIGASTVEAQERAGVEVAEKVVKILKG 307
V+E EPLP+DHPLT FDNVVLTPH+ + E+ E VV G
Sbjct: 272 VHEIEPLPRDHPLTSFDNVVLTPHLAWYSEESYAELKRRTVENVVDACAG 321
>pir||C72483 probable formate dehydrogenase APE2507 - Aeropyrum pernix (strain
K1) >gi|5106212|dbj|BAA81523.1| (AP000064) 326aa long
hypothetical formate dehydrogenase [Aeropyrum pernix]
Length = 326
Score = 199 bits (500), Expect = 4e-50
Identities = 106/282 (37%), Positives = 170/282 (59%), Gaps = 10/282 (3%)
Query: 36 DRLVELVKDVEAII--VRSKPKVTRKVIESAPKLKVIARAGVGLDNIDVEAAKERGIEVV 93
+R++E ++D + +I + ++ ++ + +++++ + G D+IDVEA G+ V
Sbjct: 34 ERVLEELRDADVVIGDYTFQMRIDAEMCAAMERVRLVQQPSTGYDHIDVEACARHGVPVA 93
Query: 94 NAPAASSRSVAELAVALMFAVARKIAFADRKMREGVWAKKQAMGI---ELEGKTLGIIGF 150
NA A++ SVAE + A+ +++ +A R+ G W + + M + +L+GKT GIIG
Sbjct: 94 NAGGANAVSVAEYTIMAALALLKRLLYAHRETVAGGWPQWRLMEMGTFDLQGKTWGIIGL 153
Query: 151 GRIGYQVAKIARALGMNLLLYDPYPNEERAKEVGGKFVDLETLLRESDIVTIHVPLLEST 210
GRIG +VAK R + + +D E+ +E+G ++ L LLRESD+V+IHVPL T
Sbjct: 154 GRIGREVAKRLRPFEVRTVYFDKVRMEDAERELGVEYRSLSRLLRESDVVSIHVPLTSET 213
Query: 211 YHLINEERLKLMKKSAILINTSRGAVVDTNALVKALEEGWIAGAGLDVYEEEPLPKDHPL 270
+I E L++MK +A+LIN SRG +VD AL +A+ E WIAGA +DVY EP P DHPL
Sbjct: 214 RGMIGEGELRMMKPTAVLINPSRGEIVDEEALARAVRERWIAGAAVDVYSREPPPPDHPL 273
Query: 271 TKFD-----NVVLTPHIGASTVEAQERAGVEVAEKVVKILKG 307
+ N++LTPHI + +A+ R E +V++LKG
Sbjct: 274 IRAAGEADVNLILTPHIAGANTDARSRIIQFSIENIVRVLKG 315
>pir||C71165 probable dehydrogenase - Pyrococcus horikoshii
>gi|3256925|dbj|BAA29608.1| (AP000002) 333aa long
hypothetical dehydrogenase [Pyrococcus horikoshii]
Length = 333
Score = 196 bits (492), Expect = 4e-49
Identities = 115/311 (36%), Positives = 180/311 (56%), Gaps = 12/311 (3%)
Query: 5 KVLVAAPLHEKAIQILKD-AGLEVIYEEYPEEDRLVELVKDVEAIIVRSKPKVTRKVIES 63
KV V + +A++ LK A +E+I YP + L ++ + IIV K+TR+V+E+
Sbjct: 4 KVGVLLKMKREALEELKKYADVEIIL--YPSGEELKGVIGRFDGIIVSPTTKITREVLEN 61
Query: 64 APKLKVIARAGVGLDNIDVEAAKERGIEVVNAPAASSRSVAELAVALMFAVARKIAFADR 123
A +LKVI+ G DNID+E A +RGI V S +VAE V L+ + RKI +AD+
Sbjct: 62 AERLKVISCHSAGYDNIDLEEATKRGIYVTKVSGLLSEAVAEFTVGLIINLMRKIHYADK 121
Query: 124 KMREGVWAKKQAMGI------ELEGKTLGIIGFGRIGYQVAKIARALGMNLLLYDPYPNE 177
+R G W + L GK +GI+G G IG +A+ G+ L + +
Sbjct: 122 FIRRGEWESHAKIWTGFKRIESLYGKKVGILGMGAIGKAIARRLIPFGVKLYYWSRHRKV 181
Query: 178 ERAKEVGGKFVDLETLLRESDIVTIHVPLLESTYHLINEERLKLMKKSAILINTSRGAVV 237
KE+ +++D++ LL +SDIV + +PL TYH+INEER+K + + L+N RGA+V
Sbjct: 182 NVEKELKARYMDIDELLEKSDIVILALPLTRDTYHIINEERVKKL-EGKYLVNIGRGALV 240
Query: 238 DTNALVKALEEGWIAGAGLDVYEEEPLPKDHPLTKFD-NVVLTPHIGASTVEAQERAGVE 296
D A+ +A+++G + G DV+E+EP+ ++H L K++ VLTPH +EAQE G
Sbjct: 241 DEKAVTEAIKQGKLKGYATDVFEKEPV-REHELFKYEWETVLTPHYAGLALEAQEDVGFR 299
Query: 297 VAEKVVKILKG 307
E ++K+L+G
Sbjct: 300 AVENLLKVLRG 310
>pir||E64569 phosphoglycerate dehydrogenase - Helicobacter pylori (strain 26695)
>gi|2313497|gb|AAD07461.1| (AE000555) phosphoglycerate
dehydrogenase (serA) [Helicobacter pylori 26695]
Length = 524
Score = 192 bits (484), Expect = 3e-48
Identities = 108/306 (35%), Positives = 182/306 (59%), Gaps = 5/306 (1%)
Query: 5 KVLVAAPLHEKAIQILKDAGLEVIYEEYPE--EDRLVELVKDVEAIIVRSKPKVTRKVIE 62
+V + P+H K IQIL +A +++ +Y + + L+E + ++A+I RS +T ++
Sbjct: 3 QVAICDPIHAKGIQIL-EAQKDIVLHDYSKCPKKELLEKLTPMDALITRSMTPITSDFLK 61
Query: 63 SAPKLKVIARAGVGLDNIDVEAAKERGIEVVNAPAASSRSVAELAVALMFAVARKIAFAD 122
LK I RAGVG+DNID+E+ ++GI V+N P A++ + EL +A + R A+
Sbjct: 62 PLTHLKSIVRAGVGVDNIDLESCSQKGIVVMNIPTANTIAAVELTMAHLINAVRSFPCAN 121
Query: 123 RKMR-EGVWAKKQAMGIELEGKTLGIIGFGRIGYQVAKIARALGMNLLLYDPYPNEERAK 181
+++ + +W ++ G EL+ K LGIIGFG IG +V A+A M +L YDPY +A
Sbjct: 122 DQIKHQRLWKREDWYGTELKNKKLGIIGFGNIGSRVGIRAKAFEMEVLAYDPYIPSSKAT 181
Query: 182 EVGGKFVDLETLLRESDIVTIHVPLLESTYHLINEERLKLMKKSAILINTSRGAVVDTNA 241
++G + + + D++TIH P + T ++I + ++ MKK IL+N +RG + + +A
Sbjct: 182 DLGVIYTKNFEDILQCDMITIHTPKNKETINMIGAKEIERMKKGVILLNCARGGLYNEDA 241
Query: 242 LVKALEEGWIAGAGLDVYEEEPLPKDHPLTKFDNVVLTPHIGASTVEAQERAGVEVAEKV 301
L +ALE + G+DV+ +EP + L NV TPHIGA+T+E+QE + A+ V
Sbjct: 242 LYEALETKKVRWLGIDVFSKEP-GIHNKLLDLPNVYATPHIGANTLESQEEISKQAAQGV 300
Query: 302 VKILKG 307
++ L+G
Sbjct: 301 MESLRG 306
>pir||C71864 d-3-phosphoglycerate dehydrogenase - Helicobacter pylori (strain
J99) >gi|4155559|gb|AAD06553.1| (AE001527)
D-3-PHOSPHOGLYCERATE DEHYDROGENASE [Helicobacter pylori
J99]
Length = 524
Score = 192 bits (484), Expect = 3e-48
Identities = 109/306 (35%), Positives = 182/306 (58%), Gaps = 5/306 (1%)
Query: 5 KVLVAAPLHEKAIQILKDAGLEVIYEEYPE--EDRLVELVKDVEAIIVRSKPKVTRKVIE 62
+V + P+H K IQIL +A +++ +Y + + L+E + ++A+I RS +T ++
Sbjct: 3 QVAICDPIHAKGIQIL-EAQKDIVLHDYSKCPKKELLEKLIPMDALITRSMTPITSDFLK 61
Query: 63 SAPKLKVIARAGVGLDNIDVEAAKERGIEVVNAPAASSRSVAELAVALMFAVARKIAFAD 122
LK I RAGVG+DNID+E+ ++GI V+N P A++ + EL +A + R A+
Sbjct: 62 PLTHLKSIVRAGVGVDNIDLESCSQKGIVVMNIPTANTIAAVELTMAHLINAVRSFPCAN 121
Query: 123 RKMR-EGVWAKKQAMGIELEGKTLGIIGFGRIGYQVAKIARALGMNLLLYDPYPNEERAK 181
+++ + +W ++ G EL+ K LGIIGFG IG +V A+A M +L YDPY +A
Sbjct: 122 DQIKHQRLWKREDWYGTELKNKKLGIIGFGNIGSRVGIRAKAFEMEVLAYDPYIPSSKAT 181
Query: 182 EVGGKFVDLETLLRESDIVTIHVPLLESTYHLINEERLKLMKKSAILINTSRGAVVDTNA 241
++G + + + D++TIH P + T ++I + ++ MKK ILIN +RG + + +A
Sbjct: 182 DLGVIYTKNFEDILQCDMITIHTPKNKETINMIGAKEIERMKKGVILINCARGGLYNEDA 241
Query: 242 LVKALEEGWIAGAGLDVYEEEPLPKDHPLTKFDNVVLTPHIGASTVEAQERAGVEVAEKV 301
L +ALE + G+DV+ +EP + L NV TPHIGA+T+E+QE + A+ V
Sbjct: 242 LYEALETKKVRWLGIDVFSKEP-GIHNKLLDLPNVYATPHIGANTLESQEEISKQAAQGV 300
Query: 302 VKILKG 307
++ L+G
Sbjct: 301 MESLRG 306
>pir||B82587 D-3-phosphoglycerate dehydrogenase XF2206 [imported] - Xylella
fastidiosa (strain 9a5c)
>gi|9107351|gb|AAF85005.1|AE004033_9 (AE004033)
D-3-phosphoglycerate dehydrogenase [Xylella fastidiosa]
Length = 413
Score = 186 bits (468), Expect = 2e-46
Identities = 111/310 (35%), Positives = 175/310 (55%), Gaps = 14/310 (4%)
Query: 3 EVKVLVAAPLHEKAIQILKDAG---LEVIYEEYPEEDRLVELVKDVEAIIVRSKPKVTRK 59
++++L+ + I+ + AG +++ PEE E+ + I +RS+ ++ +
Sbjct: 12 DIRILLLEGVSHSGIETFRAAGYSQIKIHTTSLPEEALQAEIA-EAHIIGIRSRTQLNAE 70
Query: 60 VIESAPKLKVIARAGVGLDNIDVEAAKERGIEVVNAPAASSRSVAELAVALMFAVARKIA 119
V+ A +L I +G + +D++ A+ GI V NAP +++RSVAEL +A + R I
Sbjct: 71 VLGHAKRLMAIGCFCIGTNQVDLDTAELSGIPVFNAPYSNTRSVAELIIAEAILLLRGIP 130
Query: 120 FADRKMREGVWAKKQAMGIELEGKTLGIIGFGRIGYQVAKIARALGMNLLLYDPYPNEER 179
+ + G W+K E GK LGI+G+G IG QV+ +A A+GM ++ YD E
Sbjct: 131 QKNAECHRGGWSKSAINSHEARGKVLGIVGYGHIGTQVSVLAEAMGMQVIFYD----IES 186
Query: 180 AKEVGG--KFVDLETLLRESDIVTIHVPLLESTYHLINEERLKLMKKSAILINTSRGAVV 237
+G L+ LL +D+VT+HVP +T +++ L MK A LIN SRG VV
Sbjct: 187 KLSLGNARPAASLDELLGIADVVTLHVPETAATKNMLGHAELARMKPGAHLINASRGTVV 246
Query: 238 DTNALVKALEEGWIAGAGLDVYEEEPL----PKDHPLTKFDNVVLTPHIGASTVEAQERA 293
+ +AL AL G + GA +DV+ EP P PL++ DNV+LTPHIG ST+EAQ+
Sbjct: 247 EIDALDAALVSGHLGGAAVDVFPSEPKGNSDPFISPLSRHDNVILTPHIGGSTLEAQDNI 306
Query: 294 GVEVAEKVVK 303
G+EVA K+++
Sbjct: 307 GIEVAAKLIR 316
>dbj|BAB07033.1| (AP001518) glycerate dehydrogenase [Bacillus halodurans]
Length = 324
Score = 186 bits (468), Expect = 2e-46
Identities = 114/311 (36%), Positives = 168/311 (53%), Gaps = 8/311 (2%)
Query: 4 VKVLVAAPLHEKAIQILKDA-GLEVIYEE---YPEEDRLVELVKDVEAIIVRSKPKVTRK 59
+++L L + I+ LKD + + EE P E L EL ++ + + + +
Sbjct: 1 MRLLFTRALDPEWIEPLKDEHDIRMWTEENIPMPRELFLKEL-EEADGVFTNLTDRFDVE 59
Query: 60 VIESAPKLKVIARAGVGLDNIDVEAAKERGIEVVNAPAASSRSVAELAVALMFAVARKIA 119
E A +LKV++ VG DNID++ A +RG+ V + P + + A+L AL+ A R++
Sbjct: 60 AFERAKRLKVVSTMAVGYDNIDIKEATKRGVSVGHTPGVLTEATADLTFALLMATGRRLR 119
Query: 120 FADRKMREGVWAKK---QAMGIELEGKTLGIIGFGRIGYQVAKIARALGMNLLLYDPYPN 176
+ +R W G + G TLGIIG GRIG VAK A+ M LL ++ N
Sbjct: 120 ESIDYVRNDQWKSWGPFMLTGQAIYGTTLGIIGMGRIGQAVAKRAKGFNMTLLYHNRSRN 179
Query: 177 EERAKEVGGKFVDLETLLRESDIVTIHVPLLESTYHLINEERLKLMKKSAILINTSRGAV 236
E+ KE+G + L+ LL SD V + P + T ++ + + MK +A INTSRG
Sbjct: 180 EQAEKELGATYCSLDHLLARSDYVVLLAPSTDETRKMMGPAQFQKMKSTAHFINTSRGTN 239
Query: 237 VDTNALVKALEEGWIAGAGLDVYEEEPLPKDHPLTKFDNVVLTPHIGASTVEAQERAGVE 296
VD AL +AL EGWIAGAGLDVYE+EP+ DHPL + NVV PHIG++ V +
Sbjct: 240 VDEQALYRALTEGWIAGAGLDVYEKEPISADHPLVQLPNVVALPHIGSAEVGTRREMVRL 299
Query: 297 VAEKVVKILKG 307
E ++ +KG
Sbjct: 300 AIENLLLGIKG 310
>sp|Q59516|DHGY_METEX GLYCERATE DEHYDROGENASE (NADH-DEPENDENT HYDROXYPYRUVATE REDUCTASE)
(HPR) (GDH) (HYDROXYPYRUVATE DEHYDROGENASE) (GLYOXYLATE
REDUCTASE) (HPR-A)
Length = 314
Score = 185 bits (464), Expect = 7e-46
Identities = 114/293 (38%), Positives = 168/293 (56%), Gaps = 26/293 (8%)
Query: 29 YEEY-----PEEDRLVELVKDVEAIIVRSKPKVTRKVIESAPKLKVIARAGVGLDNIDVE 83
Y+EY PEE +VE ++ E ++ P + ++ P LK+IA A G D +D
Sbjct: 26 YKEYESTWTPEE--IVERLQGAEIAMINKVP-MRADTLKQLPDLKLIAVAATGTDVVDKA 82
Query: 84 AAKERGIEVVNAPAASSRSVAELAVALMFAVARKIAFADRKMREGVWAKKQAMGI----- 138
AAK +GI VVN + +V E V LMFA+ R I +R G W K +
Sbjct: 83 AAKAQGITVVNIRNYAFNTVPEHVVGLMFALRRAIVPYANSVRRGDWNKSKQFCYFDYPI 142
Query: 139 -ELEGKTLGIIGFGRIGYQVAKIARALGMNLLLYDPYPNEERAKEVGGKFVDLETLLRES 197
++ G TLGIIG+G +G +AK A ALGM +L +D +P + VDLET+L +S
Sbjct: 143 YDIAGSTLGIIGYGALGKSIAKRAEALGMKVLAFDVFPQDG--------LVDLETILTQS 194
Query: 198 DIVTIHVPLLESTYHLINEERLKLMKKSAILINTSRGAVVDTNALVKALEEGWIAGAGLD 257
D++T+HVPL T ++I E+LK MK+SAILINT+RG +VD AL++AL++G I GAG D
Sbjct: 195 DVITLHVPLTPDTKNMIGAEQLKKMKRSAILINTARGGLVDEAALLQALKDGTIGGAGFD 254
Query: 258 VYEEEPLPKDHPL---TKFDNVVLTPHIGASTVEAQERAGVEVAEKVVKILKG 307
V +EP PKD + N+++TPH+ ++ EA + ++ + V + G
Sbjct: 255 VVAQEP-PKDGNILCDADLPNLIVTPHVAWASKEAMQILADQLVDNVEAFVAG 306
>pir||G70363 D-lactate dehydrogenase - Aquifex aeolicus
>gi|2983307|gb|AAC06898.1| (AE000704) D-lactate
dehydrogenase [Aquifex aeolicus]
Length = 334
Score = 184 bits (462), Expect = 1e-45
Identities = 116/316 (36%), Positives = 174/316 (54%), Gaps = 28/316 (8%)
Query: 11 PLHEKAIQILKDAGLEVI---YEEYPEEDRLVELVKDVEAIIVRSKPKVTRKVIESAPKL 67
P +++A LKD L++ + PE + +K E I V K+T +++ P+L
Sbjct: 14 PFYQEA---LKDLSLKIYTTDVSKVPENE-----LKKAELISVFVYDKLTEELLSKMPRL 65
Query: 68 KVIARAGVGLDNIDVEAAKERGIEVVNAPAASSRSVAELAVALMFAVARKIA-FADRKMR 126
K+I VG D+ID++ K++GI V + PA S SVAE A++ + +++ DR +
Sbjct: 66 KLIHTRSVGFDHIDLDYCKKKGILVTHIPAYSPESVAEHTFAMILTLVKRLKRIEDRVKK 125
Query: 127 EGVWAKKQAMGIELEGKTLGIIGFGRIGYQVAKIARALGMNLLLYDPYPNEERAKEVGGK 186
+ + EL TLG+IG GRIG +VA A GM +L YD E+ KE G
Sbjct: 126 LNFSQDSEILARELNRLTLGVIGTGRIGSRVAMYGLAFGMKVLCYDVVKRED-LKEKGCV 184
Query: 187 FVDLETLLRESDIVTIHVPLLESTYHLINEERLKLMKKSAILINTSRGAVVDTNALVKAL 246
+ L+ LL+ESD++++HVP + T+H+INEER+ LMK LINT+RG VVDT+AL +A
Sbjct: 185 YTSLDELLKESDVISLHVPYTKETHHMINEERISLMKDGVYLINTARGKVVDTDALYRAY 244
Query: 247 EEGWIAGAGLDVYEEEPL---------------PKDHPLTKFDNVVLTPHIGASTVEAQE 291
+ G +G GLDV+E+E + K L DNV++TPHI T ++ E
Sbjct: 245 QRGKFSGLGLDVFEDEEILILKKYTEGKATDKNLKILELACKDNVIITPHIAYYTDKSLE 304
Query: 292 RAGVEVAEKVVKILKG 307
R E + V +KG
Sbjct: 305 RIREETVKVVKAFVKG 320
>gi|9631622 contains D-isomer specific 2-hydroxyacid dehydrogenase signature;
similar to E. coli D-lactate dehydrogenase, corresponds
to Swiss-Prot Accession Number P52643 [Paramecium
bursaria Chlorella virus 1] >gi|7461865|pir||T17543
probable D-lactate dehydrogenase (EC 1.1.1.28) -
Chlorella virus PBCV-1 >gi|624075|gb|AAC96421.1|
(U42580) contains D-isomer specific 2-hydroxyacid
dehydrogenase signature; similar to E. coli D-lactate
dehydrogenase, corresponds to Swiss-Prot Accession
Number P52643 [Paramecium bursaria Chlorella virus 1]
Length = 363
Score = 180 bits (451), Expect = 2e-44
Identities = 100/272 (36%), Positives = 154/272 (55%), Gaps = 28/272 (10%)
Query: 63 SAPKLKVIARAGV--------GLDNIDVEAAKERGIEVVNAPAASSRSVAELAVALMFAV 114
SAP L ++ GV G D +D+E AKE G V PA S RSVAELA+ M A+
Sbjct: 84 SAPVLDILKNCGVSSITLRCAGFDRLDIEYAKELGFNVYRVPAYSPRSVAELALTHMMAL 143
Query: 115 ARKIAFADRKMREGVWAKKQAMGIELEGKTLGIIGFGRIGYQVAKIARALGMNLLLYDPY 174
+R I +++ G + + +G E+ KT+GIIG G+I + K+ + + ++ YD Y
Sbjct: 144 SRNIQLVLPRVKTGNYTMEGLVGREITDKTIGIIGTGKIAQEFIKLVKPMAGRIIAYDVY 203
Query: 175 PNEERAKEVGGKFVDLETLLRESDIVTIHVPLLESTYHLINEERLKLMKKSAILINTSRG 234
N+ KE+G +++ L +++ESD++++H PL++ST+H+INE+ LK MKK+A++INT+RG
Sbjct: 204 ENDI-VKEMGVEYMSLPDVIKESDVLSLHCPLMKSTFHMINEDTLKTMKKTAVIINTARG 262
Query: 235 AVVDTNALVKALEEGWIAGAGLDVYEEEP---------LP----------KDHPLTKFDN 275
++DT AL+ ALE G I+G +DVYE E LP K L N
Sbjct: 263 GLIDTEALIDALESGVISGCAMDVYEHESGLFFTDRAVLPIEDRMKFWDKKFARLANLPN 322
Query: 276 VVLTPHIGASTVEAQERAGVEVAEKVVKILKG 307
+++PH+ T EA + E + KG
Sbjct: 323 AIVSPHVAFLTKEALKNIADTTIENLTSAFKG 354
>pir||S47774 hypothetical protein o365 - Escherichia coli
>gi|466691|gb|AAB18530.1| (U00039) No definition line
found [Escherichia coli]
Length = 365
Score = 179 bits (450), Expect = 3e-44
Identities = 100/264 (37%), Positives = 153/264 (57%), Gaps = 6/264 (2%)
Query: 49 IVRSKPKVTRKVIESAPKLKVIARAGVGLDNIDVEAAKERGIEVVNAPAASSRSVAELAV 108
++ S V ++E PKL+ + VG DN DV+A R I +++ P + +VA+ +
Sbjct: 53 LLGSNENVNAALLEKMPKLRATSTISVGYDNFDVDALTARKILLMHTPTVLTETVADTLM 112
Query: 109 ALMFAVARKIAFADRKMREGVWAKKQA---MGIELEGKTLGIIGFGRIGYQVAKIARALG 165
AL+ + AR++ +++ G W G ++ KTLGI+G GRIG +A+ A G
Sbjct: 113 ALVLSTARRVVEVAERVKAGEWTASIGPDWYGTDVHHKTLGIVGMGRIGMALAQRAH-FG 171
Query: 166 MNL-LLYDPYPNEERAKE-VGGKFVDLETLLRESDIVTIHVPLLESTYHLINEERLKLMK 223
N+ +LY+ + + A+E ++ DL+TLL+ESD V + +PL + T+HL E+ MK
Sbjct: 172 FNMPILYNARRHHKEAEERFNARYCDLDTLLQESDFVCLILPLTDETHHLFGAEQFAKMK 231
Query: 224 KSAILINTSRGAVVDTNALVKALEEGWIAGAGLDVYEEEPLPKDHPLTKFDNVVLTPHIG 283
SAI IN RG VVD NAL+ AL++G I AGLDV+E+EPL D PL NVV PHIG
Sbjct: 232 SSAIFINAGRGPVVDENALIAALQKGEIHAAGLDVFEQEPLSVDSPLLSMANVVAVPHIG 291
Query: 284 ASTVEAQERAGVEVAEKVVKILKG 307
++T E + + ++ L+G
Sbjct: 292 SATHETRYGMAACAVDNLIDALQG 315
>pir||C65154 probable 2-hydroxyacid dehydrogenase in bisC-cspA intergenic region
- Escherichia coli (strain K-12)
>gi|2367243|gb|AAC76577.1| (AE000432) putative
dehydrogenase [Escherichia coli K12]
Length = 328
Score = 179 bits (450), Expect = 3e-44
Identities = 100/264 (37%), Positives = 153/264 (57%), Gaps = 6/264 (2%)
Query: 49 IVRSKPKVTRKVIESAPKLKVIARAGVGLDNIDVEAAKERGIEVVNAPAASSRSVAELAV 108
++ S V ++E PKL+ + VG DN DV+A R I +++ P + +VA+ +
Sbjct: 53 LLGSNENVNAALLEKMPKLRATSTISVGYDNFDVDALTARKILLMHTPTVLTETVADTLM 112
Query: 109 ALMFAVARKIAFADRKMREGVWAKKQA---MGIELEGKTLGIIGFGRIGYQVAKIARALG 165
AL+ + AR++ +++ G W G ++ KTLGI+G GRIG +A+ A G
Sbjct: 113 ALVLSTARRVVEVAERVKAGEWTASIGPDWYGTDVHHKTLGIVGMGRIGMALAQRAH-FG 171
Query: 166 MNL-LLYDPYPNEERAKE-VGGKFVDLETLLRESDIVTIHVPLLESTYHLINEERLKLMK 223
N+ +LY+ + + A+E ++ DL+TLL+ESD V + +PL + T+HL E+ MK
Sbjct: 172 FNMPILYNARRHHKEAEERFNARYCDLDTLLQESDFVCLILPLTDETHHLFGAEQFAKMK 231
Query: 224 KSAILINTSRGAVVDTNALVKALEEGWIAGAGLDVYEEEPLPKDHPLTKFDNVVLTPHIG 283
SAI IN RG VVD NAL+ AL++G I AGLDV+E+EPL D PL NVV PHIG
Sbjct: 232 SSAIFINAGRGPVVDENALIAALQKGEIHAAGLDVFEQEPLSVDSPLLSMANVVAVPHIG 291
Query: 284 ASTVEAQERAGVEVAEKVVKILKG 307
++T E + + ++ L+G
Sbjct: 292 SATHETRYGMAACAVDNLIDALQG 315
>sp|P37666|YIAE_ECOLI PROBABLE 2-HYDROXYACID DEHYDROGENASE IN BISC-CSPA INTERGENIC REGION
Length = 324
Score = 179 bits (450), Expect = 3e-44
Identities = 100/264 (37%), Positives = 153/264 (57%), Gaps = 6/264 (2%)
Query: 49 IVRSKPKVTRKVIESAPKLKVIARAGVGLDNIDVEAAKERGIEVVNAPAASSRSVAELAV 108
++ S V ++E PKL+ + VG DN DV+A R I +++ P + +VA+ +
Sbjct: 49 LLGSNENVNAALLEKMPKLRATSTISVGYDNFDVDALTARKILLMHTPTVLTETVADTLM 108
Query: 109 ALMFAVARKIAFADRKMREGVWAKKQA---MGIELEGKTLGIIGFGRIGYQVAKIARALG 165
AL+ + AR++ +++ G W G ++ KTLGI+G GRIG +A+ A G
Sbjct: 109 ALVLSTARRVVEVAERVKAGEWTASIGPDWYGTDVHHKTLGIVGMGRIGMALAQRAH-FG 167
Query: 166 MNL-LLYDPYPNEERAKE-VGGKFVDLETLLRESDIVTIHVPLLESTYHLINEERLKLMK 223
N+ +LY+ + + A+E ++ DL+TLL+ESD V + +PL + T+HL E+ MK
Sbjct: 168 FNMPILYNARRHHKEAEERFNARYCDLDTLLQESDFVCLILPLTDETHHLFGAEQFAKMK 227
Query: 224 KSAILINTSRGAVVDTNALVKALEEGWIAGAGLDVYEEEPLPKDHPLTKFDNVVLTPHIG 283
SAI IN RG VVD NAL+ AL++G I AGLDV+E+EPL D PL NVV PHIG
Sbjct: 228 SSAIFINAGRGPVVDENALIAALQKGEIHAAGLDVFEQEPLSVDSPLLSMANVVAVPHIG 287
Query: 284 ASTVEAQERAGVEVAEKVVKILKG 307
++T E + + ++ L+G
Sbjct: 288 SATHETRYGMAACAVDNLIDALQG 311
>gb|AAD21956.1| (AF101234) unknown [Staphylococcus aureus]
Length = 319
Score = 179 bits (450), Expect = 3e-44
Identities = 99/294 (33%), Positives = 157/294 (52%), Gaps = 6/294 (2%)
Query: 4 VKVLVAAPLHEKAIQILKDAGLEVIYEEY---PEEDRLVELVKDVEAIIVRSKPKVTRKV 60
VK++V+ + +K Q L G V++++ +D+ V ++D +A + ++ ++
Sbjct: 2 VKIVVSRKIPDKFYQQLSKLGDVVMWQKSLVPMPKDQFVTALRDADACFITLSEQIDAEI 61
Query: 61 IESAPKLKVIARAGVGLDNIDVEAAKERGIEVVNAPAASSRSVAELAVALMFAVARKIAF 120
+ +P LKVIA VG DNIDVE+A + V N P + + AEL LM A+AR+I
Sbjct: 62 LAQSPNLKVIANMAVGYDNIDVESATANNVVVTNTPNVLTETTAELGFTLMLAIARRIVE 121
Query: 121 ADRKMREGVWAK---KQAMGIELEGKTLGIIGFGRIGYQVAKIARALGMNLLLYDPYPNE 177
A++ + W G ++ T+GI G G IG A+ + N+L ++ ++
Sbjct: 122 AEKYVEADAWQSWGPYLLSGKDVFNSTIGIYGMGDIGKAFARRLQGFNTNILYHNRSRHK 181
Query: 178 ERAKEVGGKFVDLETLLRESDIVTIHVPLLESTYHLINEERLKLMKKSAILINTSRGAVV 237
+ + +V ETLL ESD + PL + T+H N E + MK AI IN RG +V
Sbjct: 182 DAEADFNATYVSFETLLAESDFIICTAPLTKETHHKFNAEAFEQMKNDAIFINIGRGQIV 241
Query: 238 DTNALVKALEEGWIAGAGLDVYEEEPLPKDHPLTKFDNVVLTPHIGASTVEAQE 291
D AL+ AL+ I GLDV EP+ HPL DNV++TPHIG+++V ++
Sbjct: 242 DETALIDALDNKEILACGLDVLANEPIDHTHPLMGRDNVLITPHIGSASVTTRD 295
>emb|CAC11910.1| (AL445065) 2-hydroxyacid dehydrogenase related protein
[Thermoplasma acidophilum]
Length = 309
Score = 177 bits (444), Expect = 2e-43
Identities = 102/267 (38%), Positives = 158/267 (58%), Gaps = 7/267 (2%)
Query: 44 DVEAIIVRSKPKVTRKVIESAPKLKVIARAGVGLDNIDVEAAKERGIEVVNAPAASSRSV 103
D E +IV + V +++ P+L+ + A +G DN+D+ A K+ GI V N P AS+ SV
Sbjct: 39 DAEILIVTTFTPVNGDLLKKMPRLRFVQVASIGYDNVDMNAMKKNGIMVSNIPTASADSV 98
Query: 104 AELAVALMFAVARKIAFADRKMREGVWAKKQAMGIELEGKTLGIIGFGRIGYQVAKIARA 163
AE A++++ ++ + F D ++R G W + +L GKT GI+G G IG +A AR
Sbjct: 99 AEHALSMVLSLIKDQRFLDAEIRSGRWPRITRSS-DLMGKTFGIVGMGSIGRALA--ARL 155
Query: 164 LGMNL-LLYDPYP--NEERAKEVGGKFVDLETLLRESDIVTIHVPLLESTYHLINEERLK 220
L + ++Y+ +E +E G FV L+ LL +SD++++HVPL E+T H+ N R
Sbjct: 156 LPFKVAIIYNDTKRMSEAEEEEYGATFVSLDRLLSDSDVISVHVPLNETTRHMFNSSRFG 215
Query: 221 LMKKSAILINTSRGAVVDTNALVKALEEGWIAGAGLDVYEEEPLPKDHPLTKFDNVVLTP 280
LMK AI INTSRG VV L++A+++ I AGLDV+E EP + PL + +N + +P
Sbjct: 216 LMKDGAIFINTSRGEVVVEKDLIEAIQKKGIR-AGLDVFEHEPPDPNSPLFRLENTLFSP 274
Query: 281 HIGASTVEAQERAGVEVAEKVVKILKG 307
HI T E+Q R E V++ ++G
Sbjct: 275 HIAGVTAESQMRFFRETIANVMRYMQG 301
>pir||C83158 probable 2-hydroxyacid dehydrogenase PA3896 [imported] -
Pseudomonas aeruginosa (strain PAO1)
>gi|9950078|gb|AAG07283.1|AE004807_2 (AE004807) probable
2-hydroxyacid dehydrogenase [Pseudomonas aeruginosa]
Length = 325
Score = 176 bits (442), Expect = 3e-43
Identities = 106/268 (39%), Positives = 149/268 (55%), Gaps = 6/268 (2%)
Query: 44 DVEAIIVRSKPKVTRKVIESAPKLKVIARAGVGLDNIDVEAAKERGIEVVNAPAASSRSV 103
D +I +P R+ +E A +L+VI+ VG DN D++ RGI + N P + +
Sbjct: 45 DTHGMIGVGRPLGARQ-LEQAKQLEVISSVSVGYDNYDLDYLNRRGIALTNTPDVLTETT 103
Query: 104 AELAVALMFAVARKIAFADRKMREGVWAKK---QAMGIELEGKTLGIIGFGRIGYQVAKI 160
A+L AL+ + AR++A D ++ G W + G ++ GK LGI+G GRIG +A+
Sbjct: 104 ADLGFALLISAARRVAELDAWVKAGNWKRTVDAPQFGTDVHGKKLGILGLGRIGAAIARR 163
Query: 161 AR-ALGMNLLLYDPYPNEERAKEVGGKFVDLETLLRESDIVTIHVPLLESTYHLINEERL 219
R GM +L + E +E+G +F+ + LL E+D V + VPL T LI L
Sbjct: 164 GRFGFGMQVLYHGNNRKPELEQELGARFLGFDELLGEADFVCVVVPLGAQTRQLIGAREL 223
Query: 220 KLMKKSAILINTSRGAVVDTNALVKALEEGWIAGAGLDVYEEEPLPKDHPLTKFDNVVLT 279
LMK SAIL+N +RG VVD ALV AL E I GAGLDVYE+EPL + PL DNVV
Sbjct: 224 GLMKPSAILVNVARGQVVDEAALVAALREKRILGAGLDVYEKEPL-AESPLFALDNVVTL 282
Query: 280 PHIGASTVEAQERAGVEVAEKVVKILKG 307
PHIG++T E + + L+G
Sbjct: 283 PHIGSATHETRRAMAERALQNFEAALRG 310
>pir||D83529 D-lactate dehydrogenase (fermentative) PA0927 [imported] -
Pseudomonas aeruginosa (strain PAO1)
>gi|9946831|gb|AAG04316.1|AE004527_3 (AE004527)
D-lactate dehydrogenase (fermentative) [Pseudomonas
aeruginosa]
Length = 329
Score = 176 bits (441), Expect = 3e-43
Identities = 108/281 (38%), Positives = 160/281 (56%), Gaps = 16/281 (5%)
Query: 24 GLEVIYEEYPEEDRLVELVKDVEAIIVRSKPKVTRKVIE--SAPKLKVIARAGVGLDNID 81
G E+ +++ + L + E + ++R V+E +A +++A G +++D
Sbjct: 24 GFELHFQQAHLQADTAVLAQGFEVVCAFVNDDLSRPVLERLAAGGTRLVALRSAGYNHVD 83
Query: 82 VEAAKERGIEVVNAPAASSRSVAELAVALMFAVARKIAFADRKMREGVWAKKQAMGIELE 141
+ AA+ G+ VV+ PA S +VAE AV L+ + R++ A + REG ++ G +L
Sbjct: 84 LAAAEALGLPVVHVPAYSPHAVAEHAVGLILTLNRRLHRAYNRTREGDFSLHGLTGFDLH 143
Query: 142 GKTLGIIGFGRIGYQVAKIARALGMNLLLYDPYPNEERAKEVGGKFVDLETLLRESDIVT 201
GK +G+IG G+IG A+I G LL YDPYPN R + +GG+++ L+ LL ESDIV+
Sbjct: 144 GKRVGVIGTGQIGETFARIMAGFGCELLAYDPYPNP-RIQALGGRYLALDALLAESDIVS 202
Query: 202 IHVPLLESTYHLINEERLKLMKKSAILINTSRGAVVDTNALVKALEEGWIAGAGLDVYEE 261
+H PL T HLI+ +RL MK A+LINT RGA+V+ AL++AL+ G + GLDVYEE
Sbjct: 203 LHCPLTADTRHLIDAQRLATMKPGAMLINTGRGALVNAAALIEALKSGQLGYLGLDVYEE 262
Query: 262 E-----------PLPKD--HPLTKFDNVVLTPHIGASTVEA 289
E PL D L F NVV+T H T EA
Sbjct: 263 EADIFFEDRSDQPLQDDVLARLLSFPNVVVTAHQAFLTREA 303
>sp|P52643|LDHD_ECOLI D-LACTATE DEHYDROGENASE (D-LDH) >gi|7431359|pir||G64888 D-lactate
dehydrogenase (EC 1.1.1.28) - Escherichia coli
>gi|1049265|gb|AAB51772.1| (U36928) D-lactate
dehydrogenase [Escherichia coli]
>gi|1742259|dbj|BAA14990.1| (D90776) D-lactate
dehydrogenase (EC 1.1.1.28) (D-LDH). [Escherichia coli]
>gi|1787645|gb|AAC74462.1| (AE000235) fermentative
D-lactate dehydrogenase, NAD-dependent [Escherichia coli
K12]
Length = 329
Score = 173 bits (435), Expect = 2e-42
Identities = 90/247 (36%), Positives = 148/247 (59%), Gaps = 3/247 (1%)
Query: 18 QILKDAGLEVIYEEYPEEDRLVELVKDVEAIIVRSKPKVTRKVIESAPK--LKVIARAGV 75
Q+ + G E+ + ++ ++ + EA+ + +R V+E K +K IA
Sbjct: 18 QVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEELKKHGVKYIALRCA 77
Query: 76 GLDNIDVEAAKERGIEVVNAPAASSRSVAELAVALMFAVARKIAFADRKMREGVWAKKQA 135
G +N+D++AAKE G++VV PA +VAE A+ +M + R+I A ++ R+ ++ +
Sbjct: 78 GFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTRDANFSLEGL 137
Query: 136 MGIELEGKTLGIIGFGRIGYQVAKIARALGMNLLLYDPYPNEERAKEVGGKFVDLETLLR 195
G + GKT G+IG G+IG + +I + GM LL +DPYP+ A E+G ++VDL TL
Sbjct: 138 TGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPS-AAALELGVEYVDLPTLFS 196
Query: 196 ESDIVTIHVPLLESTYHLINEERLKLMKKSAILINTSRGAVVDTNALVKALEEGWIAGAG 255
ESD++++H PL YHL+NE + MK +++NTSRGA++D+ A ++AL+ I G
Sbjct: 197 ESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEALKNQKIGSLG 256
Query: 256 LDVYEEE 262
+DVYE E
Sbjct: 257 MDVYENE 263
>sp|O88712|CTB1_MOUSE C-TERMINAL BINDING PROTEIN 1 >gi|3452507|emb|CAA09219.1| (AJ010483)
CtBP1 protein [Mus musculus]
Length = 440
Score = 171 bits (428), Expect = 1e-41
Identities = 104/298 (34%), Positives = 163/298 (53%), Gaps = 9/298 (3%)
Query: 19 ILKDAGLEVIYEEYPEEDRLVELVKDVEAIIVRSKPKVTRKVIESAPKLKVIARAGVGLD 78
ILKD + ++ +++ + ++ +TR+ +E L++I R G G D
Sbjct: 44 ILKDVATVAFCDAQSTQEIHEKVLNEAVGALMYHTITLTREDLEKFKALRIIVRIGSGFD 103
Query: 79 NIDVEAAKERGIEVVNAPAASSRSVAELAVALMFAVARKIAFADRKMREGVWA------K 132
NID+++A + GI V N PAAS A+ + + + R+ + + +REG +
Sbjct: 104 NIDIKSAGDLGIAVCNVPAASVEETADSTLCHILNLYRRTTWLHQALREGTRVQSVEQIR 163
Query: 133 KQAMGI-ELEGKTLGIIGFGRIGYQVAKIARALGMNLLLYDPYPNEERAKEVGGKFVD-L 190
+ A G + G+TLGIIG GR+G VA A+A G N+L YDPY ++ + +G + V L
Sbjct: 164 EVASGAARIRGETLGIIGLGRVGQAVALRAKAFGFNVLFYDPYLSDGIERALGLQRVSTL 223
Query: 191 ETLLRESDIVTIHVPLLESTYHLINEERLKLMKKSAILINTSRGAVVDTNALVKALEEGW 250
+ LL SD VT+H L E +HLIN+ +K M++ A L+NT+RG +VD AL +AL+EG
Sbjct: 224 QDLLFHSDCVTLHCGLNEHNHHLINDFTVKQMRQGAFLVNTARGGLVDEKALAQALKEGR 283
Query: 251 IAGAGLDVYEEEPLP-KDHPLTKFDNVVLTPHIGASTVEAQERAGVEVAEKVVKILKG 307
I GA LDV+E EP PL N++ TPH + +A E A ++ + + G
Sbjct: 284 IRGAALDVHESEPFSFSQGPLKDAPNLICTPHAAWYSEQASIEMREEAAREIRRAITG 341
>gi|4557497 C-terminal binding protein 1 [Homo sapiens]
>gi|11436083|ref|XP_003445.1| C-terminal binding protein
1 [Homo sapiens] >gi|6014741|sp|Q13363|CTB1_HUMAN
C-TERMINAL BINDING PROTEIN 1 (CTBP1)
>gi|3702075|gb|AAC62822.1| (U37408) phosphoprotein CtBP
[Homo sapiens] >gi|4262370|gb|AAD14597.1| (AF091555)
C-terminal binding protein [Homo sapiens]
Length = 440
Score = 171 bits (428), Expect = 1e-41
Identities = 104/298 (34%), Positives = 163/298 (53%), Gaps = 9/298 (3%)
Query: 19 ILKDAGLEVIYEEYPEEDRLVELVKDVEAIIVRSKPKVTRKVIESAPKLKVIARAGVGLD 78
ILKD + ++ +++ + ++ +TR+ +E L++I R G G D
Sbjct: 44 ILKDVATVAFCDAQSTQEIHEKVLNEAVGALMYHTITLTREDLEKFKALRIIVRIGSGFD 103
Query: 79 NIDVEAAKERGIEVVNAPAASSRSVAELAVALMFAVARKIAFADRKMREGVWA------K 132
NID+++A + GI V N PAAS A+ + + + R+ + + +REG +
Sbjct: 104 NIDIKSAGDLGIAVCNVPAASVEETADSTLCHILNLYRRATWLHQALREGTRVQSVEQIR 163
Query: 133 KQAMGI-ELEGKTLGIIGFGRIGYQVAKIARALGMNLLLYDPYPNEERAKEVGGKFVD-L 190
+ A G + G+TLGIIG GR+G VA A+A G N+L YDPY ++ + +G + V L
Sbjct: 164 EVASGAARIRGETLGIIGLGRVGQAVALRAKAFGFNVLFYDPYLSDGVERALGLQRVSTL 223
Query: 191 ETLLRESDIVTIHVPLLESTYHLINEERLKLMKKSAILINTSRGAVVDTNALVKALEEGW 250
+ LL SD VT+H L E +HLIN+ +K M++ A L+NT+RG +VD AL +AL+EG
Sbjct: 224 QDLLFHSDCVTLHCGLNEHNHHLINDFTVKQMRQGAFLVNTARGGLVDEKALAQALKEGR 283
Query: 251 IAGAGLDVYEEEPLP-KDHPLTKFDNVVLTPHIGASTVEAQERAGVEVAEKVVKILKG 307
I GA LDV+E EP PL N++ TPH + +A E A ++ + + G
Sbjct: 284 IRGAALDVHESEPFSFSQGPLKDAPNLICTPHAAWYSEQASIEMREEAAREIRRAITG 341
>gi|7304989 C-terminal binding protein 1 [Mus musculus]
>gi|6015474|dbj|BAA85180.1| (AB033122) C-terminal
binding protein 1 [Mus musculus]
Length = 441
Score = 171 bits (428), Expect = 1e-41
Identities = 104/298 (34%), Positives = 163/298 (53%), Gaps = 9/298 (3%)
Query: 19 ILKDAGLEVIYEEYPEEDRLVELVKDVEAIIVRSKPKVTRKVIESAPKLKVIARAGVGLD 78
ILKD + ++ +++ + ++ +TR+ +E L++I R G G D
Sbjct: 44 ILKDVATVAFCDAQSTQEIHEKVLNEAVGALMYHTITLTREDLEKFKALRIIVRIGSGFD 103
Query: 79 NIDVEAAKERGIEVVNAPAASSRSVAELAVALMFAVARKIAFADRKMREGVWA------K 132
NID+++A + GI V N PAAS A+ + + + R+ + + +REG +
Sbjct: 104 NIDIKSAGDLGIAVCNVPAASVEETADSTLCHILNLYRRTTWLHQALREGTRVQSVEQIR 163
Query: 133 KQAMGI-ELEGKTLGIIGFGRIGYQVAKIARALGMNLLLYDPYPNEERAKEVGGKFVD-L 190
+ A G + G+TLGIIG GR+G VA A+A G N+L YDPY ++ + +G + V L
Sbjct: 164 EVASGAARIRGETLGIIGLGRVGQAVALRAKAFGFNVLFYDPYLSDGIERALGLQRVSTL 223
Query: 191 ETLLRESDIVTIHVPLLESTYHLINEERLKLMKKSAILINTSRGAVVDTNALVKALEEGW 250
+ LL SD VT+H L E +HLIN+ +K M++ A L+NT+RG +VD AL +AL+EG
Sbjct: 224 QDLLFHSDCVTLHCGLNEHNHHLINDFTVKQMRQGAFLVNTARGGLVDEKALAQALKEGR 283
Query: 251 IAGAGLDVYEEEPLP-KDHPLTKFDNVVLTPHIGASTVEAQERAGVEVAEKVVKILKG 307
I GA LDV+E EP PL N++ TPH + +A E A ++ + + G
Sbjct: 284 IRGAALDVHESEPFSFSQGPLKDAPNLICTPHAAWYSEQASIEMREEAAREIRRAITG 341
>sp|P44501|DDH_HAEIN 2-HYDROXYACID DEHYDROGENASE HOMOLOG >gi|1073777|pir||F64047
D-2-hydroxy-acid dehydrogenase (EC 1.1.99.6) -
Haemophilus influenzae (strain Rd KW20)
>gi|1573036|gb|AAC21763.1| (U32694) D-lactate
dehydrogenase, fermentative (ldhA) [Haemophilus
influenzae Rd]
Length = 331
Score = 170 bits (427), Expect = 2e-41
Identities = 98/284 (34%), Positives = 157/284 (54%), Gaps = 16/284 (5%)
Query: 39 VELVKDVEAIIVRSKPKVTRKVIESAPKL--KVIARAGVGLDNIDVEAAKERGIEVVNAP 96
V L + E + + +RKV+E L K++A G +N+D++AA+E GI+VV P
Sbjct: 39 VRLAEHCEVVCIFVNDNGSRKVLEKLAALGVKIVALRCAGFNNVDLKAAQELGIQVVRVP 98
Query: 97 AASSRSVAELAVALMFAVARKIAFADRKMREGVWAKKQAMGIELEGKTLGIIGFGRIGYQ 156
A S +VAE + LM + R+I A ++ RE ++ + +G + G+T+G+IG G+IG
Sbjct: 99 AYSPEAVAEHTIGLMMTLNRRIHRAYQRTREANFSLEGLIGFNMYGRTVGVIGTGKIGIA 158
Query: 157 VAKIARALGMNLLLYDPYPNEERAKEVGGKFVDLETLLRESDIVTIHVPLLESTYHLINE 216
V +I + GMN+L YDP+ N +E+GG++V+L+ L +S ++T+H P YHL+N
Sbjct: 159 VMRILKGFGMNILAYDPFKNPV-VEELGGQYVELDELYAKSHVITLHCPATPENYHLLNC 217
Query: 217 ERLKLMKKSAILINTSRGAVVDTNALVKALEEGWIAGAGLDVYEEE----------PLPK 266
E MK +++NTSRG+++DT A + AL++ I G+DVYE E + +
Sbjct: 218 EAFAKMKDGVMIVNTSRGSLIDTQAAIDALKQRKIGALGMDVYENERDLFFEDKSNEVIQ 277
Query: 267 D---HPLTKFDNVVLTPHIGASTVEAQERAGVEVAEKVVKILKG 307
D L+ NV+LT H T EA + K+ G
Sbjct: 278 DDIFRRLSSCHNVLLTGHQAFLTEEALTNIADVTLSNIYKLKSG 321
>pir||F69895 phosphoglycerate dehydrogenase homolog yoaD - Bacillus subtilis
>gi|2619022|gb|AAB84446.1| (AF027868) YoaD [Bacillus
subtilis] >gi|2634250|emb|CAB13749.1| (Z99114) similar
to phosphoglycerate dehydrogenase [Bacillus subtilis]
Length = 344
Score = 170 bits (427), Expect = 2e-41
Identities = 108/316 (34%), Positives = 173/316 (54%), Gaps = 18/316 (5%)
Query: 6 VLVAAPLHEKAIQILKDAGLEVIYEEYPE------EDRLVELVKDVEAI-IVRSKPKVTR 58
VLV AP +E+ + L++ V Y+ + E ED L++L+K A ++ +VT
Sbjct: 14 VLVTAPYNEEGRKELENLFGSVAYQSWKEQGRAYREDELIQLLKATNATGLITELDQVTD 73
Query: 59 KVIESAPKLKVIARAGVGLDNIDVEAAKERGIEVVNAPAASSRSVAELAVALMFAVARKI 118
V S P+L + N+DV AA +RGI V P ++++VAE+ + + + R
Sbjct: 74 SVFASVPELSFVGVCRGMPSNVDVAAASKRGIPVFYTPGRNAQAVAEMFIGNVISFLRHT 133
Query: 119 AFADRKMREGVW------AKKQAMGIELEGKTLGIIGFGRIGYQVAKIARALGMNLLLYD 172
+ +++ +++G W A + G EL GKT+G+IGFG +G ++AK+ A + YD
Sbjct: 134 SASNQWLKDGEWDSDYLQAYVKFKGNELTGKTVGMIGFGAVGQRIAKLLTAFDCKIKYYD 193
Query: 173 PYPNEERAKEVGGKFVDLETLLRESDIVTIHVPLLESTYHLINEERLKLMKKSAILINTS 232
PY ++ + L+T+ +SDIV++H+P E T LI+ + LMK+SAI +NTS
Sbjct: 194 PYIQDDHPLY---EKASLKTVFSDSDIVSVHLPRTEETLGLIDRQYFDLMKESAIFVNTS 250
Query: 233 RGAVVDTNALVKALEEGWIAGAGLDV-YEEEPLPKDHPLTKFDNVVLTPHIGASTVEAQE 291
R VV+ L+ L+E I+GA LDV Y E P D+ L NV+ TPH+ +T E ++
Sbjct: 251 RAVVVNREDLLFVLKEHKISGAILDVFYHEPPEESDYELISLPNVLATPHLAGATFEVED 310
Query: 292 RAGVEVAEKVVKILKG 307
V + K +K KG
Sbjct: 311 H-HVTILNKALKKWKG 325
>gb|AAF51963.1| (AE003602) CG1236 gene product [Drosophila melanogaster]
Length = 325
Score = 170 bits (427), Expect = 2e-41
Identities = 108/311 (34%), Positives = 167/311 (52%), Gaps = 8/311 (2%)
Query: 5 KVLVAAP-LHEKAIQIL-KDAGLEVIYEEYP-EEDRLVELVKDVEAIIVRSKPKVTRKVI 61
KV V P + + +++L K + +E P L+ +V +A+ KV ++V+
Sbjct: 6 KVYVTRPDVDDSGLELLRKSCQVSTWHETNPVPRSELIRVVAGKDALYCALTDKVDKEVL 65
Query: 62 ESA-PKLKVIARAGVGLDNIDVEAAKERGIEVVNAPAASSRSVAELAVALMFAVARKIAF 120
++A P+LK +A VG D+IDVE ++RGI V P + + AEL +AL+ A R++
Sbjct: 66 DAAGPQLKCVATISVGYDHIDVEECRKRGIRVGFTPDVLTDATAELTLALLLATNRRLFE 125
Query: 121 ADRKMREGVWAKKQAM---GIELEGKTLGIIGFGRIGYQVAKIARALGMNLLLYDPYP-N 176
A++++ G W M G L+G +G++GFGRIG ++A + Y
Sbjct: 126 ANKQVYNGGWKSWAPMWMCGQGLKGSRVGLLGFGRIGQEIAARIVPFKPTEITYTTRSLR 185
Query: 177 EERAKEVGGKFVDLETLLRESDIVTIHVPLLESTYHLINEERLKLMKKSAILINTSRGAV 236
+ A V + VD + +LRESD++ + L T + N + MK + ILINT+RG V
Sbjct: 186 PKEAAAVNARHVDFDEMLRESDLIVVCCALTPETKEIFNATAFQKMKPNCILINTARGGV 245
Query: 237 VDTNALVKALEEGWIAGAGLDVYEEEPLPKDHPLTKFDNVVLTPHIGASTVEAQERAGVE 296
VD AL +AL+ I AGLDV EPLP D PL K DNVV+ PHIG++ +E ++
Sbjct: 246 VDQKALYEALKTKRILAAGLDVTTPEPLPIDDPLLKLDNVVILPHIGSADIETRKEMSRI 305
Query: 297 VAEKVVKILKG 307
A ++ L G
Sbjct: 306 TARNILAALAG 316
>gi|9506527 C-terminal binding protein 1 [Rattus norvegicus]
>gi|3925357|gb|AAC79427.1| (AF067795) BFA-dependent
ADP-ribosylation substrate BARS50 [Rattus norvegicus]
Length = 430
Score = 169 bits (425), Expect = 3e-41
Identities = 103/298 (34%), Positives = 163/298 (54%), Gaps = 9/298 (3%)
Query: 19 ILKDAGLEVIYEEYPEEDRLVELVKDVEAIIVRSKPKVTRKVIESAPKLKVIARAGVGLD 78
ILKD + ++ +++ + ++ +TR+ +E L++I R G G D
Sbjct: 33 ILKDVATVAFCDAQSTQEIHEKVLNEAVGALMYHTITLTREDLEKFKALRIIVRIGSGFD 92
Query: 79 NIDVEAAKERGIEVVNAPAASSRSVAELAVALMFAVARKIAFADRKMREGVWA------K 132
NID+++A + GI V N PAAS A+ + + + R+ + + +REG +
Sbjct: 93 NIDIKSAGDLGIAVCNVPAASVEETADSTLCHILNLYRRTTWLHQALREGTRVQSVEQIR 152
Query: 133 KQAMGI-ELEGKTLGIIGFGRIGYQVAKIARALGMNLLLYDPYPNEERAKEVGGKFVD-L 190
+ A G + G+TLGIIG GR+G VA A+A G N+L YDPY ++ + +G + V L
Sbjct: 153 EVASGAARIRGETLGIIGLGRVGQAVALRAKAFGFNVLFYDPYLSDGIERALGLQRVSTL 212
Query: 191 ETLLRESDIVTIHVPLLESTYHLINEERLKLMKKSAILINTSRGAVVDTNALVKALEEGW 250
+ LL SD VT+H L E +HLIN+ +K M++ A L+NT+RG ++D AL +AL+EG
Sbjct: 213 QDLLFHSDCVTLHCGLNEHNHHLINDFTVKQMRQGAFLVNTARGGLMDEKALAQALKEGR 272
Query: 251 IAGAGLDVYEEEPLP-KDHPLTKFDNVVLTPHIGASTVEAQERAGVEVAEKVVKILKG 307
I GA LDV+E EP PL N++ TPH + +A E A ++ + + G
Sbjct: 273 IRGAALDVHESEPFSFSQGPLKDAPNLICTPHAAWYSEQASIEMREEAAREIRRAITG 330
>pir||F81053 D-lactate dehydrogenase NMB1685 [imported] - Neisseria meningitidis
(group B strain MD58) >gi|7226939|gb|AAF42033.1|
(AE002519) D-lactate dehydrogenase [Neisseria
meningitidis MC58]
Length = 332
Score = 169 bits (425), Expect = 3e-41
Identities = 88/241 (36%), Positives = 145/241 (59%), Gaps = 3/241 (1%)
Query: 24 GLEVIYEEYPEEDRLVELVKDVEAIIVRSKPKVTRKVIESAPKL--KVIARAGVGLDNID 81
G E+ + ++ + + ++ + EA+ + +R V+E ++ K +A G +N+D
Sbjct: 24 GFELEFFDFMLDAKTAKMAEGAEAVCIFVNDDGSRPVLEKLAQIGVKTVALRCAGFNNVD 83
Query: 82 VEAAKERGIEVVNAPAASSRSVAELAVALMFAVARKIAFADRKMREGVWAKKQAMGIELE 141
++AA+E G++VV PA S SVAE V LM + R+I A ++ R+ ++ + G +
Sbjct: 84 LKAAEELGLKVVRVPAYSPESVAEHTVGLMLTLNRRIHKAYQRTRDANFSLEGLTGFNMY 143
Query: 142 GKTLGIIGFGRIGYQVAKIARALGMNLLLYDPYPNEERAKEVGGKFVDLETLLRESDIVT 201
GKT G+IG G+IG +I + GMNLL YDP+ N E A+++GGK+VDL+ L SDI+T
Sbjct: 144 GKTAGVIGTGKIGIATMRILKGFGMNLLAYDPFCNPE-AEKIGGKYVDLDELYARSDIIT 202
Query: 202 IHVPLLESTYHLINEERLKLMKKSAILINTSRGAVVDTNALVKALEEGWIAGAGLDVYEE 261
+H P ++++NE MK ++INTSRG ++D+ A ++AL+ I G+DVYE
Sbjct: 203 LHCPATPENHYMLNEAAFDKMKDGVMIINTSRGGLIDSAAAIEALKRRKIGALGMDVYEN 262
Query: 262 E 262
E
Sbjct: 263 E 263
>pir||F83362 probable 2-hydroxyacid dehydrogenase PA2263 [imported] -
Pseudomonas aeruginosa (strain PAO1)
>gi|9948291|gb|AAG05651.1|AE004652_4 (AE004652) probable
2-hydroxyacid dehydrogenase [Pseudomonas aeruginosa]
Length = 328
Score = 169 bits (425), Expect = 3e-41
Identities = 107/307 (34%), Positives = 162/307 (51%), Gaps = 13/307 (4%)
Query: 8 VAAPLHEKAIQILKDAGLEVIYEEYPEED---RLVELVKDVEAIIVRSKPKVTRKVIESA 64
++APL E+ + +EV+ E P D RL + + + ++ S ++ +++ A
Sbjct: 10 LSAPLMERLRE-----RVEVLLVEEPGRDGLARLRDALPEAHGLLGASL-RLDAGLLDLA 63
Query: 65 PKLKVIARAGVGLDNIDVEAAKERGIEVVNAPAASSRSVAELAVALMFAVARKIAFADRK 124
P+L+ IA VG+DN D++ RGI + N P + + A+ AL+ A AR++
Sbjct: 64 PRLEAIASVSVGVDNYDIDYLDRRGILLSNTPDVLTETTADTGFALILATARRVVELAGW 123
Query: 125 MREGVWAKKQA---MGIELEGKTLGIIGFGRIGYQVAKIAR-ALGMNLLLYDPYPNEERA 180
+R G W K G ++ GKTLGI+G GRIG +A+ GM +L + P
Sbjct: 124 VRAGEWKKSVGAAQFGTDVHGKTLGIVGMGRIGEALARRGHHGFGMRVLYHSHSPKPHVE 183
Query: 181 KEVGGKFVDLETLLRESDIVTIHVPLLESTYHLINEERLKLMKKSAILINTSRGAVVDTN 240
+ + L+ LL ESD V + +PL +T LI + M+ AI IN SRG VVD
Sbjct: 184 ERYAASYRPLDALLEESDFVCLTLPLTAATEGLIGAAQFARMRPQAIFINISRGRVVDEA 243
Query: 241 ALVKALEEGWIAGAGLDVYEEEPLPKDHPLTKFDNVVLTPHIGASTVEAQERAGVEVAEK 300
AL++AL + I AGLDV+E EPL D PL + NVV TPHIG++T E +E +
Sbjct: 244 ALIEALAQRRIRAAGLDVFEREPLSPDSPLLRLPNVVATPHIGSATEETREAMARCAVDN 303
Query: 301 VVKILKG 307
++ L G
Sbjct: 304 LLAALAG 310
>pir||S75499 D-isomer specific 2-hydroxyacid dehydrogenase family -
Synechocystis sp. (strain PCC 6803)
>gi|1653144|dbj|BAA18060.1| (D90911) D-isomer specific
2-hydroxyacid dehydrogenase family [Synechocystis sp.]
Length = 318
Score = 169 bits (424), Expect = 3e-41
Identities = 98/274 (35%), Positives = 156/274 (56%), Gaps = 4/274 (1%)
Query: 35 EDRLVELVKDVEAIIVRSKPKVTRKV-IESAPKLKVIARAGVGLDNIDVEAAKERGIEVV 93
E L E + D + +I P R + I KLK +A+ G+G+D ID+ AAK+ GI
Sbjct: 41 EAELCEQIADFDGVIAGDDPFTARVLTIGKQGKLKALAKWGIGVDAIDLAAAKQLGILTS 100
Query: 94 NAPAASSRSVAELAVALMFAVARKIAFADRKMREGVWAKKQAMGIELEGKTLGIIGFGRI 153
N P VA++A+ + +AR++ D+ +R+G W K + G L GKT GIIG G I
Sbjct: 101 NTPNVFGDEVADVAIGYLILLARELHCIDQAVRQGEWLKIR--GHSLRGKTAGIIGVGSI 158
Query: 154 GYQVAKIARALGMNLLLYDPYP-NEERAKEVGGKFVDLETLLRESDIVTIHVPLLESTYH 212
G +A +++G+ LL YDP+P + + ++ G V L+ +L+++D + + L +H
Sbjct: 159 GQAIAVRLQSMGLKLLGYDPHPISADFCEQTGLHPVPLQDVLQQADCLFLACNLTPDNFH 218
Query: 213 LINEERLKLMKKSAILINTSRGAVVDTNALVKALEEGWIAGAGLDVYEEEPLPKDHPLTK 272
L+N + MK LIN +RG +VD AL++ L+ G +A A LDV+E+EPL D PLT+
Sbjct: 219 LLNADTFDQMKPGVWLINVARGGLVDQAALIETLQTGKVAKAALDVFEQEPLAADSPLTQ 278
Query: 273 FDNVVLTPHIGASTVEAQERAGVEVAEKVVKILK 306
V+L H G++T EA + + +V+ L+
Sbjct: 279 LPQVILGSHNGSNTREAVLKVNQLAIDNLVRDLQ 312
>pir||C81380 probable D-2-hydroxyacid dehydrogenase Cj0373 [imported] -
Campylobacter jejuni (strain NCTC 11168)
>gi|6967847|emb|CAB74209.1| (AL139075) putative
D-2-hydroxyacid dehydrogenase [Campylobacter jejuni]
Length = 311
Score = 169 bits (423), Expect = 4e-41
Identities = 107/297 (36%), Positives = 167/297 (56%), Gaps = 15/297 (5%)
Query: 2 IEVKVLVAAPLHEKAIQILKDAGLEVIYEEYPEEDRLVELVKDVEAIIVRSKPKVTRKVI 61
+++ L AA L + + + + G IY +E + +E +KD + + +K + + VI
Sbjct: 1 MKIVCLDAATLGDYDLSVFEKFGSLQIYTTTNKE-QTIERLKDAN-VAMTNKVVIDKDVI 58
Query: 62 ESAPKLKVIARAGVGLDNIDVEAAKERGIEVVNAPAASSRSVAELAVALMFAVARKIAFA 121
++ LK+I G++NID+E AKE+GI V NA S+ SV + A MFA ++ +
Sbjct: 59 DACKNLKLILETATGVNNIDIEYAKEKGIIVKNAAGYSTMSVVQHTFAFMFAFLNQVLYY 118
Query: 122 DRKMREGVWAKK------QAMGIELEGKTLGIIGFGRIGYQVAKIARALGMNLLLYDPYP 175
D+ +EG W + + L GK GIIG G IG +VAKI++A G + Y
Sbjct: 119 DKWSKEGKWCESPIFTDYSRILNTLSGKKHGIIGLGTIGKEVAKISKAFGAEIYYYSTSG 178
Query: 176 NEERAKEVGGKFVDLETLLRESDIVTIHVPLLESTYHLINEERLKLMKKSAILINTSRGA 235
+ A V ++L+ LL+ DI++IH PL E T +L+ E LKL+K +AILIN RG
Sbjct: 179 ANKNADFV---HLELKDLLKTCDIISIHAPLNEKTKNLLAFEELKLLKDNAILINVGRGG 235
Query: 236 VVDTNALVKALEEGWIAGAGLDVYEEEPLPKDHPLTKF---DNVVLTPHIGASTVEA 289
+V+ N L K ++E I GLDV E EP+ K+HPL +N+++TPH+ ++ EA
Sbjct: 236 IVNENDLAKIIDEKNIR-VGLDVLEIEPMMKNHPLLSIKNKENLIITPHVAWASKEA 291
>sp|P45250|YF56_HAEIN PUTATIVE 2-HYDROXYACID DEHYDROGENASE HI1556 >gi|1075442|pir||F64129
probable phosphoglycerate dehydrogenase homolog -
Haemophilus influenzae (strain Rd KW20)
>gi|1574400|gb|AAC23205.1| (U32830) 2-hydroxyacid
dehydrogenase [Haemophilus influenzae Rd]
Length = 315
Score = 168 bits (422), Expect = 6e-41
Identities = 99/262 (37%), Positives = 149/262 (56%), Gaps = 15/262 (5%)
Query: 31 EYPEEDRLVELVKDVEAIIVRSKPKVTRKVIESAPKLKVIARAGVGLDNIDVEAAKERGI 90
E+ ++ +E VKD + I++ SK R+ ++ PKLK+IA G +N+D+ AA+E GI
Sbjct: 30 EHTSAEQTIERVKDAD-IVITSKVIFDRETLQQLPKLKLIAITATGTNNVDLVAAEEMGI 88
Query: 91 EVVNAPAASSRSVAELAVALMFAVARKIAFADRKMREGVWAKKQAMGI------ELEGKT 144
V N SS +V E + L+F++ +A R E WA+ + ++ G T
Sbjct: 89 AVRNVTGYSSTTVPEHVIGLIFSLKHSLAGWLRDQTEAKWAESKQFCYFDYPITDVRGST 148
Query: 145 LGIIGFGRIGYQVAKIARALGMNLLLYDPYPNEERAKEVGGKFVDLETLLRESDIVTIHV 204
LG+ G G +G +V ++A A+GM +L Y + A + + +L+++DIVT+H
Sbjct: 149 LGVFGKGCLGTEVGRLANAVGMKVL----YAEHKDATVCREGYTPFDEVLKQADIVTLHC 204
Query: 205 PLLESTYHLINEERLKLMKKSAILINTSRGAVVDTNALVKALEEGWIAGAGLDVYEEEPL 264
PL E+T LIN E L MKK A LINT RG ++D ALV AL+ G + GA LDV +EP
Sbjct: 205 PLTETTKDLINAETLSKMKKGAFLINTGRGPLIDELALVDALKTGHLGGAALDVMVKEPP 264
Query: 265 PKDHPL----TKFDNVVLTPHI 282
KD+PL N+++TPHI
Sbjct: 265 EKDNPLILAAKTMPNLIITPHI 286
>gb|AAD14596.1| (AF091554) C-terminal binding protein [Xenopus laevis]
Length = 440
Score = 168 bits (420), Expect = 1e-40
Identities = 102/298 (34%), Positives = 161/298 (53%), Gaps = 9/298 (3%)
Query: 19 ILKDAGLEVIYEEYPEEDRLVELVKDVEAIIVRSKPKVTRKVIESAPKLKVIARAGVGLD 78
ILKD + ++ +++ + ++ +TR+ +E L++I R G G D
Sbjct: 44 ILKDVATVAFCDAQSTQEIHEKVLNEAVGALMYHTITLTREDLEKFKALRIIVRIGSGFD 103
Query: 79 NIDVEAAKERGIEVVNAPAASSRSVAELAVALMFAVARKIAFADRKMREGVWA------K 132
NID+++A + GI V N PAAS A+ + + + R+ + + +REG +
Sbjct: 104 NIDIKSAGDLGIAVCNVPAASVEETADSTMCHILNLYRRTTWLHQALREGTRVQSVEQIR 163
Query: 133 KQAMGI-ELEGKTLGIIGFGRIGYQVAKIARALGMNLLLYDPYPNEERAKEVGGKFVD-L 190
+ A G + G+TLGIIG GR+G VA A+ G N+ YDPY ++ + +G + V L
Sbjct: 164 EVASGAARIRGETLGIIGLGRVGQAVALRAKTFGFNVFFYDPYLSDGIERALGLQRVSTL 223
Query: 191 ETLLRESDIVTIHVPLLESTYHLINEERLKLMKKSAILINTSRGAVVDTNALVKALEEGW 250
+ LL SD VT+H L E +HLIN+ +K M++ A L+NT+RG +VD AL +AL+EG
Sbjct: 224 QDLLFHSDCVTLHCGLNEHNHHLINDFTIKQMRQGAFLVNTARGGLVDEKALAQALKEGR 283
Query: 251 IAGAGLDVYEEEPLP-KDHPLTKFDNVVLTPHIGASTVEAQERAGVEVAEKVVKILKG 307
I GA LDV+E EP PL N++ TPH + +A E A ++ + + G
Sbjct: 284 IRGAALDVHESEPFSFTQGPLKDAPNLICTPHAAWYSEQASIEMREEAAREIRRAITG 341
>pir||F81822 D-lactate dehydrogenase (EC 1.1.1.28) NMA1944 [imported] -
Neisseria meningitidis (group A strain Z2491)
>gi|7380576|emb|CAB85164.1| (AL162757) D-lactate
dehydrogenase [Neisseria meningitidis Z2491]
Length = 332
Score = 167 bits (418), Expect = 2e-40
Identities = 86/241 (35%), Positives = 146/241 (59%), Gaps = 3/241 (1%)
Query: 24 GLEVIYEEYPEEDRLVELVKDVEAIIVRSKPKVTRKVIESAPKL--KVIARAGVGLDNID 81
G E+ + ++ + + ++ + EA+ + +R V+E ++ K +A G +N+D
Sbjct: 24 GFELEFFDFMLDAKTAKMAEGAEAVCIFVNDDGSRPVLEKLAQIGVKTVALRCAGFNNVD 83
Query: 82 VEAAKERGIEVVNAPAASSRSVAELAVALMFAVARKIAFADRKMREGVWAKKQAMGIELE 141
++AA+E G++VV PA S SVAE V LM + R+I A ++ R+ ++ + G +
Sbjct: 84 LKAAEELGLKVVRVPAYSPESVAEHTVGLMLTLNRRIHKAYQRTRDANFSLEGLTGFNMY 143
Query: 142 GKTLGIIGFGRIGYQVAKIARALGMNLLLYDPYPNEERAKEVGGKFVDLETLLRESDIVT 201
GKT G+IG G+IG +I + GMNLL +DP+ N E A+++GG++VDL+ L +SDI+T
Sbjct: 144 GKTAGVIGTGKIGIATMRILKGFGMNLLAHDPFCNPE-AEKIGGRYVDLDELYAQSDIIT 202
Query: 202 IHVPLLESTYHLINEERLKLMKKSAILINTSRGAVVDTNALVKALEEGWIAGAGLDVYEE 261
+H P ++++NE MK ++INTSRG ++D+ A ++AL+ I G+DVYE
Sbjct: 203 LHCPSTPENHYMLNEAAFDKMKDGVMIINTSRGGLIDSAAAIEALKRRKIGALGMDVYEN 262
Query: 262 E 262
E
Sbjct: 263 E 263
>gb|AAF53930.1| (AE003668) CG9332 gene product [Drosophila melanogaster]
Length = 598
Score = 166 bits (415), Expect = 4e-40
Identities = 106/312 (33%), Positives = 168/312 (52%), Gaps = 9/312 (2%)
Query: 5 KVLVA-APLHEKAIQILKDAG--LEVIYEEYPEEDRLVELVKDVEAIIVRSKPKVTRKVI 61
KVL+A + + I+ILK+ L+VI E ++E ++ A+I + + +++
Sbjct: 279 KVLIAHTDVPPEGIEILKEQCEILQVINEPPKNRPEILEKIRGAHAVIWGGRDILNAEIL 338
Query: 62 ESA-PKLKVIARAGVGLDNIDVEAAKERGIEVVNAPAASSRSVAELAVALMFAVARKIAF 120
++A P+LK ++ G++N+DV K+RGI + + PA + +VA+L V L+ A AR+
Sbjct: 339 DAAGPQLKAVSTMSSGINNVDVPELKKRGIPLGSTPAMLTVAVADLTVGLLIAAARRFQE 398
Query: 121 ADRKMREGVWAKKQA---MGIELEGKTLGIIGFGRIGYQVAKIARALGMNLLLYDPYP-- 175
RK+ W K +G ++ T+G GFG IG VAK + +LY
Sbjct: 399 GRRKIDSDKWDKDHLNWMLGQDIRDSTVGFYGFGGIGQAVAKRLMGFDIKRMLYTTRNRV 458
Query: 176 NEERAKEVGGKFVDLETLLRESDIVTIHVPLLESTYHLINEERLKLMKKSAILINTSRGA 235
+++ + K VD ETLL ESD + I PL + T L N MK++A+L+N RG
Sbjct: 459 SQDIEERFNAKKVDFETLLAESDFLIIASPLTKETLGLFNATVFNKMKETAVLVNVGRGK 518
Query: 236 VVDTNALVKALEEGWIAGAGLDVYEEEPLPKDHPLTKFDNVVLTPHIGASTVEAQERAGV 295
+V+ + L +AL+ I AGLDV + EPLP + L DNVV+TPH+G +T + A
Sbjct: 519 IVNQDDLYEALKSNRIFAAGLDVMDPEPLPSNDKLLTLDNVVVTPHVGYATRRTRVDAAN 578
Query: 296 EVAEKVVKILKG 307
+ V+K L G
Sbjct: 579 LASRNVLKGLAG 590
Score = 109 bits (269), Expect = 5e-23
Identities = 65/236 (27%), Positives = 107/236 (44%), Gaps = 23/236 (9%)
Query: 43 KDVEAIIVRSKPKVTRKVIESAPKLKVIARAGVGLDNIDVEAAKERGIEVVNAPAASSRS 102
+ E II +S P ++++ P L+ ++ G+D +D+ ++RGI + + P +
Sbjct: 51 RGAETIICQSVPPSRDEILQKVPGLRCVSTMSSGIDFVDIPEFQKRGIPLGHTPGVVKNA 110
Query: 103 VAELAVALMFAVARKIAFADRKMREGVWAKKQA---MGIELEGKTLGIIGFGRIGYQVAK 159
VA+LA+ LM A R ++ W +Q MG E+ +G GFG I +AK
Sbjct: 111 VADLAIGLMIAAGRHFHAGRTEIERSQWKIEQINWMMGQEIRDSVIGFFGFGGISQAIAK 170
Query: 160 IARALGMNLLLYDPYPNEERAKEVGGKFVDLETLLRESDIVTIHVPLLESTYHLINEERL 219
+ + ++Y +E + + V E LL+ESD + + PL T N +
Sbjct: 171 RLQCWDVAKIIYHTRTRKENDGDFKAEHVSFEQLLQESDFLVVAAPLTNETREKFNGKAF 230
Query: 220 KLMKKSAILINTSRGAVVDTNALVKALEEGWIAGAGLDVYEEEPLPKDHPLTKFDN 275
LMK+S++ +N +RG GLDV EPLP + PL N
Sbjct: 231 NLMKRSSVFVNVARG--------------------GLDVTTPEPLPANSPLLNVPN 266
>emb|CAB92262.1| (AL356595) putative 2-hydroxyacid dehydrogenase [Streptomyces
coelicolor A3(2)]
Length = 330
Score = 165 bits (414), Expect = 5e-40
Identities = 97/255 (38%), Positives = 147/255 (57%), Gaps = 6/255 (2%)
Query: 32 YPEEDRLVELVKDVEAII-VRSKPKVTRKVIESAPKLKVIARAGVGLDNIDVEAAKERGI 90
+P+ED L + D + ++ +R + +I P+LK++ +G+ ID AA G+
Sbjct: 37 FPDEDALAAALADADIVVTLRERVPFPGSLIARLPRLKLLVASGMRNSVIDYAAADAHGV 96
Query: 91 EVVNAPAASSRSVAELAVALMFAVARKIAFADRKMREG-VWAKKQAMGIELEGKTLGIIG 149
V A+SS EL AL+ +AR I +REG W +Q +G +L G+ LG++G
Sbjct: 97 TVCGT-ASSSTPPVELTWALILGLARGIVQEANGLREGGPW--QQTVGADLHGRRLGLLG 153
Query: 150 FGRIGYQVAKIARALGMNLLLYDPYPNEERAKEVGGKFVDL-ETLLRESDIVTIHVPLLE 208
G+IG +VA++ A GM + + +ER EVG + E LLR +D V++H+ L E
Sbjct: 154 LGKIGGRVAQVGLAFGMRVSAWSQNLTQERTDEVGVELASSKEELLRTADFVSVHLALGE 213
Query: 209 STYHLINEERLKLMKKSAILINTSRGAVVDTNALVKALEEGWIAGAGLDVYEEEPLPKDH 268
T L+ L L+K +A L+NTSR A+VD AL+ AL EG IAGAG+DV++ EPLP H
Sbjct: 214 RTRGLLGPAELALLKPTAYLVNTSRAAIVDQEALLAALHEGRIAGAGVDVFDTEPLPAGH 273
Query: 269 PLTKFDNVVLTPHIG 283
P+ ++ TPH+G
Sbjct: 274 PMRTAPRLLATPHLG 288
>sp|P30799|DDH_ZYMMO 2-HYDROXYACID DEHYDROGENASE HOMOLOG >gi|538722|pir||D40649
D-2-hydroxy-acid dehydrogenase (EC 1.1.99.6) - Zymomonas
mobilis >gi|155574|gb|AAA71934.1| (L09650) Shows
homology to D-isomer specific
2-hydroxyaciddehydrogenases, including Lactobacillus
plantarum lactatedehydrogenase [Zymomonas mobilis]
Length = 331
Score = 165 bits (413), Expect = 7e-40
Identities = 99/266 (37%), Positives = 152/266 (56%), Gaps = 16/266 (6%)
Query: 40 ELVKDVEAIIVRSKPKVTRKVIESAPKL--KVIARAGVGLDNIDVEAAKERGIEVVNAPA 97
E KD EA+ + + +V+E L K++A G +N+D++AAK+ I+VV PA
Sbjct: 40 EKAKDAEAVCIFVNDEANAEVLEILAGLGIKLVALRCAGYNNVDLDAAKKLNIKVVRVPA 99
Query: 98 ASSRSVAELAVALMFAVARKIAFADRKMREGVWAKKQAMGIELEGKTLGIIGFGRIGYQV 157
S SVAE AV ++ + R+I+ +++RE ++ + +G+++ KT+GIIG G IG
Sbjct: 100 YSPYSVAEYAVGMLLTLNRQISRGLKRVRENNFSLEGLIGLDVHDKTVGIIGVGHIGSVF 159
Query: 158 AKI-ARALGMNLLLYDPYPNEERAKEVGGKFVDLETLLRESDIVTIHVPLLESTYHLINE 216
A I G N++ Y P+P+ E A++VG +F L+ ++ SDI+++H PL +H+IN
Sbjct: 160 AHIMTHGFGANVIAYKPHPDPELAEKVGFRFTSLDEVIETSDIISLHCPLTPENHHMING 219
Query: 217 ERLKLMKKSAILINTSRGAVVDTNALVKALEEGWIAGAGLDVYEEE-PLPKDH------- 268
E L KK L+NTSRG +VDT A++K+L+ + G DVYEEE PL ++
Sbjct: 220 ETLARAKKGFYLVNTSRGGLVDTKAVIKSLKAKHLGGYAADVYEEEGPLFFENHADDIIE 279
Query: 269 -----PLTKFDNVVLTPHIGASTVEA 289
L F NVV T H T EA
Sbjct: 280 DDILERLIAFPNVVFTGHQAFLTKEA 305
>pir||A82490 D-lactate dehydrogenase VCA0192 [imported] - Vibrio cholerae (group
O1 strain N16961) >gi|9657584|gb|AAF96105.1| (AE004359)
D-lactate dehydrogenase [Vibrio cholerae]
Length = 331
Score = 165 bits (413), Expect = 7e-40
Identities = 84/240 (35%), Positives = 140/240 (58%), Gaps = 3/240 (1%)
Query: 25 LEVIYEEYPEEDRLVELVKDVEAIIVRSKPKVTRKVIESAPK--LKVIARAGVGLDNIDV 82
L + + ++ D+ ++ K E + ++ V+E + ++IA G D +D+
Sbjct: 26 LSLHFHDFRLTDKTAQMAKGCEVVCAFVNDELHASVLEQLYQGGTRLIAMRCAGFDKVDL 85
Query: 83 EAAKERGIEVVNAPAASSRSVAELAVALMFAVARKIAFADRKMREGVWAKKQAMGIELEG 142
EAAK G++VV PA S +VAE V +M + R+ A ++ R+ ++ +G G
Sbjct: 86 EAAKRLGMQVVRVPAYSPEAVAEHTVGMMLCLNRRFHKAYQRTRDANFSLDGLVGFNFHG 145
Query: 143 KTLGIIGFGRIGYQVAKIARALGMNLLLYDPYPNEERAKEVGGKFVDLETLLRESDIVTI 202
KT+G+IG G+IG +I + LGM +L +DPYPN + A +G ++V+L L +SD++T+
Sbjct: 146 KTVGVIGSGKIGVATMRILQGLGMQILCFDPYPNPD-AIALGARYVELSELFAQSDVITL 204
Query: 203 HVPLLESTYHLINEERLKLMKKSAILINTSRGAVVDTNALVKALEEGWIAGAGLDVYEEE 262
H P+ + YHL+NE MK ++INTSRG ++D+ A ++AL+ G I GLDVY+ E
Sbjct: 205 HCPMSKENYHLLNESAFDQMKDGVMIINTSRGELLDSVAAIEALKRGRIGALGLDVYDNE 264
>gb|AAC28494.1| (AF079881) D-3-phosphoglycerate dehydrogenase [Entodinium caudatum]
Length = 318
Score = 164 bits (410), Expect = 1e-39
Identities = 107/285 (37%), Positives = 161/285 (55%), Gaps = 26/285 (9%)
Query: 28 IYEEYPEEDRLVELVKDVEAIIVRSKPKVTRKVIESAPKLKVIARAGVGLDNIDVEAAKE 87
+ E+Y + L++ +KD AIIVRS K+T+++++S+ LKVIARAG G DNID+ A +
Sbjct: 44 LLEKYKTKQELMDSIKDANAIIVRSD-KITKEIMDSSNNLKVIARAGAGFDNIDLGYASK 102
Query: 88 RGIEVVNAPAASSRSVAELAVALMFAVARKIAFADRKMREGVWAKKQAMGIELEGKTLGI 147
+GI V+N P ++ +VAEL L + +A R +G + G EL+GK LG+
Sbjct: 103 KGIVVMNTPGQNANAVAELVFGL-------LVYAKRNFYDG------SSGTELKGKKLGL 149
Query: 148 IGFGRIGYQVAKIARALGMNLLLYDPYPNEERAKEVGGKFVD-LETLLRESDIVTIHVPL 206
+ FG +G VA+IA+ GM + YD + +E ++ G VD E L + DIV++H+P
Sbjct: 150 LAFGNVGRNVARIAKGFGMEIYSYDAFVPKEVLEKEGIHAVDKQEDLFTDCDIVSLHIPA 209
Query: 207 LESTYHLINEERLKLMKKSAILINTSRGAVVDTNALVKALEEGWIAGAGLDV-YEEEPLP 265
+ T + IN + MKK+AILINTSR V++ L+K +EE D+ Y + P
Sbjct: 210 TKETINSINYDLCSKMKKNAILINTSRKEVINEKELIKLMEE------RKDIKYITDLKP 263
Query: 266 KDHP--LTKF-DNVVLTP-HIGASTVEAQERAGVEVAEKVVKILK 306
+H L KF TP +GA T EA AG A +++ K
Sbjct: 264 DNHEEFLNKFKGRYFATPKKMGAQTQEANINAGKAAANQIIDFFK 308
>gb|AAD41370.1|AF152006_1 (AF152006) Tcf-3 co-repressor CtBP [Xenopus laevis]
Length = 437
Score = 164 bits (410), Expect = 1e-39
Identities = 98/296 (33%), Positives = 160/296 (53%), Gaps = 13/296 (4%)
Query: 19 ILKDAGLEVIYEEYPEEDRLVELVKDVEAIIVRSKPKVTRKVIESAPKLKVIARAGVGLD 78
ILKD + ++ +++ + ++ ++R+ +E L++I + G G D
Sbjct: 47 ILKDVATVAFCDAQSTQEIHEKVLSEAVGALMYHTITLSREDLEKFKALRIIIKIGSGYD 106
Query: 79 NIDVEAAKERGIEVVNAPAASSRSVAELAVALMFAVARKIAFADRKMREG-----VWAKK 133
NID+++A E GI V N P+AS A+ + + + R++ + + MREG V +
Sbjct: 107 NIDIKSAAELGIAVCNIPSASVEETADSTLCHILNLYRRVTWLHQAMREGNRPASVEQIR 166
Query: 134 QAMG--IELEGKTLGIIGFGRIGYQVAKIARALGMNLLLYDPYPNEERAKEVG-GKFVDL 190
+ G + G+TLGIIG GRIG VA A+A ++ YDPY + + +G + L
Sbjct: 167 EVAGGAARIRGETLGIIGLGRIGQAVALRAKAFNFTVIFYDPYLADGVERSLGLQRMATL 226
Query: 191 ETLLRESDIVTIHVPLLESTYHLINEERLKLMKKSAILINTSRGAVVDTNALVKALEEGW 250
+ LL SD +T+H L E +HLIN+ +K M++ L+NT+RG +VD AL +AL++G
Sbjct: 227 QELLMHSDCITLHCNLNEHNHHLINDFTIKQMRQGCFLVNTARGGLVDEKALAQALKDGR 286
Query: 251 IAGAGLDVYEEEPLP-KDHPLTKFDNVVLTPHIG----ASTVEAQERAGVEVAEKV 301
I GA LDV+E EP PL N++ TPH +++EA+E A E+ +
Sbjct: 287 IRGAALDVHESEPFSFSQGPLKDAPNLICTPHTAWYSEHASIEAREEAAKEIRRAI 342
>gi|6753548 C-terminal binding protein 2 [Mus musculus]
>gi|3513571|gb|AAC33873.1| (AF059735) C-terminal binding
protein 2 CtBP2 [Mus musculus]
>gi|6015476|dbj|BAA85181.1| (AB033123) C-terminal
binding protein 2 [Mus musculus]
Length = 445
Score = 163 bits (409), Expect = 2e-39
Identities = 101/296 (34%), Positives = 162/296 (54%), Gaps = 13/296 (4%)
Query: 19 ILKDAGLEVIYEEYPEEDRLVELVKDVEAIIVRSKPKVTRKVIESAPKLKVIARAGVGLD 78
ILKD + ++ +++ + ++ +TR+ +E L+VI R G G D
Sbjct: 50 ILKDLATVAFCDAQSTQEIHEKVLNEAVGAMMYHTITLTREDLEKFKALRVIVRIGSGYD 109
Query: 79 NIDVEAAKERGIEVVNAPAASSRSVAELAVALMFAVARKIAFADRKMREGVWA------K 132
N+D++AA E GI V N P+A+ A+ V + + R+ + + +REG +
Sbjct: 110 NVDIKAAGELGIAVCNIPSAAVEETADSTVCHILNLYRRNTWLYQALREGTRVQSVEQIR 169
Query: 133 KQAMGI-ELEGKTLGIIGFGRIGYQVAKIARALGMNLLLYDPYPNEERAKEVGGKFV-DL 190
+ A G + G+TLG+IGFGR G VA A+A G +++ YDPY + + +G + V L
Sbjct: 170 EVASGAARIRGETLGLIGFGRTGQAVAVRAKAFGFSVIFYDPYLQDGIERSLGVQRVYTL 229
Query: 191 ETLLRESDIVTIHVPLLESTYHLINEERLKLMKKSAILINTSRGAVVDTNALVKALEEGW 250
+ LL +SD V++H L E +HLIN+ +K M++ A L+N +RG +VD AL +AL+EG
Sbjct: 230 QDLLYQSDCVSLHCNLNEHNHHLINDFTIKQMRQGAFLVNAARGGLVDEKALAQALKEGR 289
Query: 251 IAGAGLDVYEEEPLP-KDHPLTKFDNVVLTPHIG----ASTVEAQERAGVEVAEKV 301
I GA LDV+E EP PL N++ TPH +++E +E A E+ +
Sbjct: 290 IRGAALDVHESEPFSFAQGPLKDAPNLICTPHTAWYSEQASLEMREAAATEIRRAI 345
>pir||S48189 hydroxypyruvate reductase (EC 1.1.1.81) - Hyphomicrobium
methylovorum >gi|1304133|dbj|BAA06662.1| (D31857)
hydroxypyruvate reductase [Hyphomicrobium methylovorum]
Length = 322
Score = 163 bits (408), Expect = 3e-39
Identities = 103/319 (32%), Positives = 177/319 (55%), Gaps = 17/319 (5%)
Query: 1 MIEVKVLVAAPLHEKAIQILKDAGLEVIYEEYPEE--DRLVELVKDVEAIIVRSKPKVTR 58
M + K+L+ PL E A+ +++ + + + P+ D ++E K V+A+++ K +
Sbjct: 1 MSKKKILITWPLPEAAMARARESYDVIAHGDDPKITIDEMIETAKSVDALLITLNEKCRK 60
Query: 59 KVIESAPK-LKVIARAGVGLDNIDVEAAKERGIEVVNAPAASSRSVAELAVALMFAVARK 117
+VI+ P+ +K I+ +G D+ID++A K RGI+V NAP + + AE+A+ L+ AR+
Sbjct: 61 EVIDRIPENIKCISTYSIGFDHIDLDACKARGIKVGNAPHGVTVATAEIAMLLLLGSARR 120
Query: 118 IAFADRKMREGVWA---KKQAMGIELEGKTLGIIGFGRIGYQVAKIARALGMNLLLYDPY 174
++ +R W Q +G L+ KTLGI GFG+IG +A+ AR MN+ YD Y
Sbjct: 121 AGEGEKMIRTRSWPGWQPLQLVGQRLDNKTLGIYGFGKIGQALAQRARGFDMNVHYYDIY 180
Query: 175 PNEERAK-EVGGKFV-----DLETLLRESDIVTIHVPLLESTYHLINEERLKLMKKSAIL 228
RAK EV K+ L++LL+ S +I+ P T + N+E ++ + + AI+
Sbjct: 181 ----RAKPEVEAKYNATYHDSLDSLLKVSQFFSINAPSTPETRYFFNKETIEKLPQGAIV 236
Query: 229 INTSRGAVVDTNALVKALEEGWIAGAGLDVYEEEPLPKDHPLTKFDNVVLTPHIGASTVE 288
+NT+RG +V + ++ AL+ G +A AG DV+ EP + N L PH+G++ +E
Sbjct: 237 VNTARGDLVKDDDVIAALKSGRLAYAGFDVFAGEP-NINEGYYDLPNTFLFPHLGSAAIE 295
Query: 289 AQERAGVEVAEKVVKILKG 307
A+ + G E + + G
Sbjct: 296 ARNQMGFEALDNIDAFFAG 314
>gi|4557499 C-terminal binding protein 2 [Homo sapiens]
>gi|11432544|ref|XP_005960.1| similar to C-terminal
binding protein 2 (H. sapiens) [Homo sapiens]
>gi|3182976|sp|P56545|CTB2_HUMAN C-TERMINAL BINDING
PROTEIN 2 >gi|2909777|gb|AAC39603.1| (AF016507)
C-terminal binding protein 2 [Homo sapiens]
Length = 445
Score = 163 bits (408), Expect = 3e-39
Identities = 100/296 (33%), Positives = 162/296 (53%), Gaps = 13/296 (4%)
Query: 19 ILKDAGLEVIYEEYPEEDRLVELVKDVEAIIVRSKPKVTRKVIESAPKLKVIARAGVGLD 78
ILKD + ++ +++ + ++ +TR+ +E L+VI R G G D
Sbjct: 50 ILKDLATVAFCDAQSTQEIHEKVLNEAVGAMMYHTITLTREDLEKFKALRVIVRIGSGYD 109
Query: 79 NIDVEAAKERGIEVVNAPAASSRSVAELAVALMFAVARKIAFADRKMREGVWA------K 132
N+D++AA E GI V N P+A+ A+ + + + R+ + + +REG +
Sbjct: 110 NVDIKAAGELGIAVCNIPSAAVEETADSTICHILNLYRRNTWLYQALREGTRVQSVEQIR 169
Query: 133 KQAMGI-ELEGKTLGIIGFGRIGYQVAKIARALGMNLLLYDPYPNEERAKEVGGKFV-DL 190
+ A G + G+TLG+IGFGR G VA A+A G +++ YDPY + + +G + V L
Sbjct: 170 EVASGAARIRGETLGLIGFGRTGQAVAVRAKAFGFSVIFYDPYLQDGIERSLGVQRVYTL 229
Query: 191 ETLLRESDIVTIHVPLLESTYHLINEERLKLMKKSAILINTSRGAVVDTNALVKALEEGW 250
+ LL +SD V++H L E +HLIN+ +K M++ A L+N +RG +VD AL +AL+EG
Sbjct: 230 QDLLYQSDCVSLHCNLNEHNHHLINDFTIKQMRQGAFLVNAARGGLVDEKALAQALKEGR 289
Query: 251 IAGAGLDVYEEEPLP-KDHPLTKFDNVVLTPHIG----ASTVEAQERAGVEVAEKV 301
I GA LDV+E EP PL N++ TPH +++E +E A E+ +
Sbjct: 290 IRGAALDVHESEPFSFAQGPLKDAPNLICTPHTAWYSEQASLEMREAAATEIRRAI 345
>pir||S45534 phosphoglycerate dehydrogenase (EC 1.1.1.95) - Bacillus subtilis
(fragment) >gi|410116|gb|AAA67502.1| (L09228)
phosphoglycerate dehydrogenase [Bacillus subtilis]
Length = 419
Score = 162 bits (407), Expect = 3e-39
Identities = 84/195 (43%), Positives = 124/195 (63%), Gaps = 1/195 (0%)
Query: 113 AVARKIAFADRKMREGVWAKKQAMGIELEGKTLGIIGFGRIGYQVAKIARALGMNLLLYD 172
++ R I A+ ++ W + +G EL GKTLGI+G GRIG ++A+ A GM + ++D
Sbjct: 3 SLMRHIPQANISVKSREWNRTAYVGSELYGKTLGIVGLGRIGSEIAQRRGAFGMTVHVFD 62
Query: 173 PYPNEERAKEVGGKFVDLETLLRESDIVTIHVPLLESTYHLINEERLKLMKKSAILINTS 232
P+ EERAK++G E +L +DI+T+H PL + T L+N+E + KK LIN +
Sbjct: 63 PFLTEERAKKIGVNSRTFEEVLESADIITVHTPLTKETKGLLNKETIAKTKKGVRLINCA 122
Query: 233 RGAVVDTNALVKALEEGWIAGAGLDVYEEEPLPKDHPLTKFDNVVLTPHIGASTVEAQER 292
RG ++D AL++ALE G +AGA LDV+E EP P D+ L V+ TPH+GAST EAQ
Sbjct: 123 RGGIIDEAALLEALENGHVAGAALDVFEVEP-PVDNKLVDHPLVIATPHLGASTKEAQLN 181
Query: 293 AGVEVAEKVVKILKG 307
+V+E+V++ KG
Sbjct: 182 VAAQVSEEVLQFAKG 196
>pir||F82068 2-hydroxyacid dehydrogenase family protein VC2504 [imported] -
Vibrio cholerae (group O1 strain N16961)
>gi|9657086|gb|AAF95646.1| (AE004320) 2-hydroxyacid
dehydrogenase family protein [Vibrio cholerae]
Length = 325
Score = 162 bits (407), Expect = 3e-39
Identities = 91/269 (33%), Positives = 152/269 (55%), Gaps = 13/269 (4%)
Query: 48 IIVRSKPKVTRKVIESAPKLKVIARAGVGLDNIDVEAAKERGIEVVNAPAASSRSVAELA 107
I++ +K +TR+++ PKLK+IA + G +N+D+ A ++ I V N ++RSV E
Sbjct: 54 IVITNKVVLTREMLIQLPKLKLIAISATGTNNVDLPACRDLNIAVCNVQGYATRSVPEHV 113
Query: 108 VALMFAVARKIAFADRKMREGVWAKKQAMGI------ELEGKTLGIIGFGRIGYQVAKIA 161
VA+MFA+ R + + G W + + ++ G T+GIIG G +G A +A
Sbjct: 114 VAMMFALRRNLIGYHNDIAAGEWQRHKQFCFFTHPIGDIAGSTMGIIGSGALGQATANLA 173
Query: 162 RALGMNLLLYDPYPNEERAKEVGGKFVDLETLLRESDIVTIHVPLLESTYHLINEERLKL 221
RALGM++LL + + E + E +L +SD++++H PL + T ++I+E L
Sbjct: 174 RALGMHVLLAE----RKGQVECRDGYTSFEQVLAQSDVLSLHCPLTDETRNIISEAELAQ 229
Query: 222 MKKSAILINTSRGAVVDTNALVKALEEGWIAGAGLDVYEEEPLPKDHPL---TKFDNVVL 278
M +A+LINT RG +VD ALV AL+ IAGAG+DV+ EP D+PL N++L
Sbjct: 230 MNPNALLINTGRGGLVDEQALVDALKRRQIAGAGVDVFSAEPADMDNPLIANRDLPNLLL 289
Query: 279 TPHIGASTVEAQERAGVEVAEKVVKILKG 307
TPH+ + + ++ + + + ++G
Sbjct: 290 TPHVAWGSDSSIQQLATILIDNISAFMRG 318
>gb|AAF16561.1|AC012563_14 (AC012563) hydroxypyruvate reductase (HPR); 50972-48670
[Arabidopsis thaliana]
Length = 386
Score = 162 bits (406), Expect = 4e-39
Identities = 101/260 (38%), Positives = 148/260 (56%), Gaps = 21/260 (8%)
Query: 68 KVIARAGVGLDNIDVEAAKERGIEVVNAPAASSRSVAELAVALMFAVARKIAFADRKMRE 127
K + VG +N+DVEAA + GI V N P + + AELA +L A AR+I AD MR
Sbjct: 88 KAFSNMAVGYNNVDVEAANKYGIAVGNTPGVLTETTAELAASLSLAAARRIVEADEFMRG 147
Query: 128 GV---WAKKQAMGIELEGKTLGIIGFGRIGYQVAKI-ARALGMNLLLYDPYPNEERAKEV 183
G+ W +G L+G+T+G+IG GRIG A++ MNL+ +D Y + K V
Sbjct: 148 GLYEGWLPHLFVGNLLKGQTVGVIGAGRIGSAYARMMVEGFKMNLIYFDLYQSTRLEKFV 207
Query: 184 G--GKFV--------------DLETLLRESDIVTIHVPLLESTYHLINEERLKLMKKSAI 227
G+F+ +E +LRE+D++++H L ++TYHL+N+ERL +MKK AI
Sbjct: 208 TAYGQFLKANGEQPVTWKRASSMEEVLREADLISLHPVLDKTTYHLVNKERLAMMKKEAI 267
Query: 228 LINTSRGAVVDTNALVKALEEGWIAGAGLDVYEEEPLPKDHPLTKFDNVVLTPHIGASTV 287
L+N SRG V+D ALV+ L+E + GLDV+EEEP K L N ++ PHI +++
Sbjct: 268 LVNCSRGPVIDEAALVEHLKENPMFRVGLDVFEEEPFMKP-GLADTKNAIVVPHIASASK 326
Query: 288 EAQERAGVEVAEKVVKILKG 307
+E A V+ +KG
Sbjct: 327 WTREGMATLAALNVLGRVKG 346
>pir||F82022 probable glycerate dehydrogenase (EC 1.1.1.29) NMA0274 [imported] -
Neisseria meningitidis (group A strain Z2491)
>gi|7379036|emb|CAB83582.1| (AL162752) putative
glycerate dehydrogenase [Neisseria meningitidis Z2491]
Length = 322
Score = 162 bits (406), Expect = 4e-39
Identities = 97/280 (34%), Positives = 155/280 (54%), Gaps = 13/280 (4%)
Query: 36 DRLVELVKDVEAIIVRSKPKVTRKVIESAPKLKVIARAGVGLDNIDVEAAKERGIEVVNA 95
D E V+D I++ +K ++ +I + P+L++IA + G++N+D+ AAK G+ V N
Sbjct: 41 DETAERVRDAH-IVITNKVMISADIIAANPQLELIAVSATGVNNVDIGAAKAAGVAVCNV 99
Query: 96 PAASSRSVAELAVALMFAVARKIAFADRKMREGVWAKKQ------AMGIELEGKTLGIIG 149
A + SVAE A LM A+ R + R + G+W K A +L GKTL + G
Sbjct: 100 RAYGNESVAEHAFMLMIALMRNLPAYQRDVAAGLWEKSPFFCHYGAPIRDLNGKTLAVFG 159
Query: 150 FGRIGYQVAKIARALGMNLLLYDPYPNEERAKEVGGKFVDLETLLRESDIVTIHVPLLES 209
G IG +A+ A+A GM ++ + + A V +V E ++ +D++++H PL
Sbjct: 160 RGNIGRTLARYAQAFGMRVV----FAEHKHAHAVREGYVSFEDAVQTADVLSLHCPLNAQ 215
Query: 210 TYHLINEERLKLMKKSAILINTSRGAVVDTNALVKALEEGWIAGAGLDVYEEEPLPKDHP 269
T ++I E L+ MK A+LIN RG +VD NAL+ AL+ G I GAG+DV EEP +P
Sbjct: 216 TENMIGENELRQMKPGAVLINCGRGGLVDENALLAALKYGQIGGAGVDVLTEEPPRGGNP 275
Query: 270 L--TKFDNVVLTPHIGASTVEAQERAGVEVAEKVVKILKG 307
L + N+++TPH ++ EA +R + + +KG
Sbjct: 276 LLNARLPNLIVTPHTAWASREALDRLFDILLANIHSFVKG 315
>sp|P56546|CTB2_MOUSE C-TERMINAL BINDING PROTEIN 2 >gi|2909779|gb|AAC40043.1| (AF016508)
C-terminal binding protein 2 [Mus musculus]
Length = 420
Score = 162 bits (405), Expect = 6e-39
Identities = 100/298 (33%), Positives = 163/298 (54%), Gaps = 13/298 (4%)
Query: 17 IQILKDAGLEVIYEEYPEEDRLVELVKDVEAIIVRSKPKVTRKVIESAPKLKVIARAGVG 76
+ ILKD + ++ +++ + ++ +TR+ +E L+VI R G G
Sbjct: 23 MHILKDLATVAFCDAQSTQEIHEKVLNEAVGAMMYHTITLTREDLEKFKALRVIVRIGSG 82
Query: 77 LDNIDVEAAKERGIEVVNAPAASSRSVAELAVALMFAVARKIAFADRKMREG--VWAKKQ 134
DN+D++AA E GI V N P+A+ A+ V + + R+ + + +REG V + +Q
Sbjct: 83 YDNVDIKAAGELGIAVCNIPSAAVEETADSTVCHILNLYRRNTWLYQALREGTRVQSVEQ 142
Query: 135 AMGI-----ELEGKTLGIIGFGRIGYQVAKIARALGMNLLLYDPYPNEERAKEVGGKFV- 188
+ + G+TLG+IGFGR G VA A+A G +++ YDPY + + +G + V
Sbjct: 143 IRDVASGAARIRGETLGLIGFGRTGQAVAVRAKAFGFSVIFYDPYLQDGIERSLGVQRVY 202
Query: 189 DLETLLRESDIVTIHVPLLESTYHLINEERLKLMKKSAILINTSRGAVVDTNALVKALEE 248
L+ LL +SD V++H L E +HLIN+ +K M++ A L+N +RG +VD AL +AL+E
Sbjct: 203 TLQDLLYQSDCVSLHCNLNEHNHHLINDFTIKQMRQGAFLVNAARGGLVDEKALAQALKE 262
Query: 249 GWIAGAGLDVYEEEPLP-KDHPLTKFDNVVLTPHIG----ASTVEAQERAGVEVAEKV 301
I GA LDV+E EP PL N++ TPH +++E +E A E+ +
Sbjct: 263 ARIRGAALDVHESEPFSFAQGPLKDAPNLICTPHTAWYSEQASLEMREAAATEIRRAI 320
>pir||H81245 glycerate dehydrogenase NMB0029 [imported] - Neisseria meningitidis
(group B strain MD58) >gi|7225248|gb|AAF40500.1|
(AE002361) glycerate dehydrogenase [Neisseria
meningitidis MC58]
Length = 317
Score = 161 bits (404), Expect = 8e-39
Identities = 95/265 (35%), Positives = 148/265 (55%), Gaps = 13/265 (4%)
Query: 36 DRLVELVKDVEAIIVRSKPKVTRKVIESAPKLKVIARAGVGLDNIDVEAAKERGIEVVNA 95
D E V+D I++ +K ++ +I + P+L++IA + G++N+D+ AAK G+ V N
Sbjct: 36 DETAERVRDAH-IVITNKVMISADIIAANPQLELIAVSATGVNNVDIGAAKAAGVAVCNV 94
Query: 96 PAASSRSVAELAVALMFAVARKIAFADRKMREGVWAKKQ------AMGIELEGKTLGIIG 149
A + SVAE A LM A+ R + R + G+W K A +L GKTL + G
Sbjct: 95 RAYGNESVAEHAFMLMIALMRNLPAYQRDVAAGLWEKSPFFCHYGAPIRDLNGKTLAVFG 154
Query: 150 FGRIGYQVAKIARALGMNLLLYDPYPNEERAKEVGGKFVDLETLLRESDIVTIHVPLLES 209
G IG +A A+A GM ++ + + A V +V E +R +D++++H PL
Sbjct: 155 RGNIGRTLAGYAQAFGMGVV----FAEHKHASAVREGYVSFEDAVRAADVLSLHCPLNAQ 210
Query: 210 TYHLINEERLKLMKKSAILINTSRGAVVDTNALVKALEEGWIAGAGLDVYEEEPLPKDHP 269
T ++I E L+ MK A+LIN RG +VD NAL+ AL+ G I GAG+DV EP +P
Sbjct: 211 TENMIGENELRQMKPGAVLINCGRGGLVDENALLAALKYGQIGGAGVDVLTNEPPKNGNP 270
Query: 270 L--TKFDNVVLTPHIGASTVEAQER 292
L + N+++TPH ++ EA +R
Sbjct: 271 LLNARLPNLIVTPHTAWASREALDR 295
>gb|AAF09059.1|AC011717_26 (AC011717) putative D-isomer specific 2-hydroxyacid dehydrogenase;
59386-58329 [Arabidopsis thaliana]
Length = 313
Score = 161 bits (403), Expect = 1e-38
Identities = 93/261 (35%), Positives = 148/261 (56%), Gaps = 8/261 (3%)
Query: 33 PEEDRLVELVKD-VEAIIVRSKPKVTRKVIESAPKLKVIARAGVGLDNIDVEAAKERGIE 91
PE+ L+E ++ + A++ + ++I P L++++ VGLD ID+ KE+GI
Sbjct: 33 PEKSVLLETHRNSIRAVVGNASAGADAQLISDLPNLEIVSSFSVGLDKIDLGKCKEKGIR 92
Query: 92 VVNAPAASSRSVAELAVALMFAVARKIAFADRKMREGVWAKKQ-AMGIELEGKTLGIIGF 150
V N P + VA+LA+ L+ A+ R++ DR +R G W + + + + GK++GIIG
Sbjct: 93 VTNTPDVLTEDVADLAIGLILALLRRLCECDRYVRSGKWKQGEFQLTTKFSGKSVGIIGL 152
Query: 151 GRIGYQVAKIARALGMNLLLYDPYPNEERAKEVGGKFVDLETLLRESDIVTIHVPLLEST 210
GRIG +AK A A + Y + A + VD L + SDI+ + PL E T
Sbjct: 153 GRIGTAIAKRAEAFSCPINYYSRTIKPDVAYKYYPTVVD---LAQNSDILVVACPLTEQT 209
Query: 211 YHLINEERLKLMKKSAILINTSRGAVVDTNALVKALEEGWIAGAGLDVYEEEP-LPKDHP 269
H+++ + + + +LIN RG VD L+KAL EG + GA LDV+E+EP +P++
Sbjct: 210 RHIVDRQVMDALGAKGVLINIGRGPHVDEQELIKALTEGRLGGAALDVFEQEPHVPEE-- 267
Query: 270 LTKFDNVVLTPHIGASTVEAQ 290
L +NVVL PH+G+ TVE +
Sbjct: 268 LFGLENVVLLPHVGSGTVETR 288
>dbj|BAA19751.1| (D85339) hydroxypyruvate reductase [Arabidopsis thaliana]
Length = 386
Score = 160 bits (401), Expect = 2e-38
Identities = 100/260 (38%), Positives = 147/260 (56%), Gaps = 21/260 (8%)
Query: 68 KVIARAGVGLDNIDVEAAKERGIEVVNAPAASSRSVAELAVALMFAVARKIAFADRKMRE 127
K + VG +N+DVEAA + GI V N P + + AELA +L A AR+I AD MR
Sbjct: 88 KAFSNMAVGYNNVDVEAANKYGIAVGNTPGVLTETTAELAASLSLAAARRIVEADEFMRG 147
Query: 128 GV---WAKKQAMGIELEGKTLGIIGFGRIGYQVAKI-ARALGMNLLLYDPYPNEERAKEV 183
G+ W +G L+G+T+G+IG GRIG A++ MNL+ +D Y + K V
Sbjct: 148 GLYEGWLPHLFVGNLLKGQTVGVIGAGRIGSAYARMMVEGFKMNLIYFDLYQSTRLEKFV 207
Query: 184 G--GKFV--------------DLETLLRESDIVTIHVPLLESTYHLINEERLKLMKKSAI 227
G+F+ +E +LRE+D++++H L ++TYHL+N+ERL +MKK AI
Sbjct: 208 TAYGQFLKANGEQPVTWKRASSMEEVLREADLISLHPVLDKTTYHLVNKERLAMMKKEAI 267
Query: 228 LINTSRGAVVDTNALVKALEEGWIAGAGLDVYEEEPLPKDHPLTKFDNVVLTPHIGASTV 287
L+N SRG V+ ALV+ L+E + GLDV+EEEP K L N ++ PHI +++
Sbjct: 268 LVNCSRGPVIHEAALVEHLKENPMFRVGLDVFEEEPFMKP-GLADMKNAIVVPHIASASK 326
Query: 288 EAQERAGVEVAEKVVKILKG 307
+E A V+ +KG
Sbjct: 327 WTREGMATLAALNVLGRVKG 346
>gb|AAG18731.1| (AE004977) phosphoglycerate dehydrogenase; SerA3 [Halobacterium sp.
NRC-1]
Length = 323
Score = 160 bits (400), Expect = 2e-38
Identities = 97/274 (35%), Positives = 143/274 (51%), Gaps = 5/274 (1%)
Query: 38 LVELVKDVEAIIVRSKPKV---TRKVIESAPKLKVIARAGVGLDNIDVEAAKERGIEVVN 94
LV V D A V P+ + E + I RAGVG+D ID AA + G+ V N
Sbjct: 41 LVAAVDDTGADAVVGGPETPVPAETIAEIDGDVAAIVRAGVGVDAIDCAAAADHGVAVAN 100
Query: 95 APAASSRSVAELAVALMFAVARKIAFADRKMREGVWAKKQAMG-IELEGKTLGIIGFGRI 153
AP+ +R V E A++L+F AR++ DR+ R G WA A + L T+G +GFG I
Sbjct: 101 APSYCTREVGEHALSLVFGAARRLHEYDRQTRRGGWAWNDAPAPLRLADATVGFVGFGEI 160
Query: 154 GYQVAKIARALGMNLLLYDPYPNEERAKEVGGKFVDLETLLRESDIVTIHVPLLESTYHL 213
VA A + +++ YDPY + A+ G + E + +SD++ + PL E T L
Sbjct: 161 ARGVADTATTVAESVIAYDPYVDAATAERHGVAMAEFEAVCAQSDVLVVFAPLTEETRGL 220
Query: 214 INEERLKLMKKSAILINTSRGAVVDTNALVKALEEGWIAGAGLDVYEEEPLPKDHPLTKF 273
++E + + A+++N RGAVVD AL ALE+G ++ A LDV EP P + PL
Sbjct: 221 VDEAACNRLPEGAVVVNVGRGAVVDDAALAGALEDGPVSAAALDVLPTEP-PVESPLVGR 279
Query: 274 DNVVLTPHIGASTVEAQERAGVEVAEKVVKILKG 307
+V++TPH G + A E +A V + G
Sbjct: 280 SDVLVTPHCGWYSEAAAESLVASLAGTVAAVADG 313
>dbj|BAA36181.1| (D88272) formate dehydrogenase [Hordeum vulgare]
Length = 377
Score = 159 bits (398), Expect = 4e-38
Identities = 92/256 (35%), Positives = 143/256 (54%), Gaps = 4/256 (1%)
Query: 56 VTRKVIESAPKLKVIARAGVGLDNIDVEAAKERGIEVVNAPAASSRSVAELAVALMFAVA 115
VT + I+ A +++ AG+G D+ID+ AA G+ V +++ SVAE + + +
Sbjct: 102 VTAEKIKKAKTPELLLTAGIGSDHIDLPAAAAAGLTVARVTGSNTVSVAEDELMRILILL 161
Query: 116 RKIAFADRKMREGVW--AKKQAMGIELEGKTLGIIGFGRIGYQVAKIARALGMNLLLYDP 173
R +++ +G W A +LEGKT+G +G GR G + + + NLL +D
Sbjct: 162 RNFLPGYQQVVKGEWNVAGIAHRAYDLEGKTVGTVGAGRYGRLLLQRLKPFNCNLLYHDR 221
Query: 174 YP-NEERAKEVGGKFV-DLETLLRESDIVTIHVPLLESTYHLINEERLKLMKKSAILINT 231
N E KE+G KF DL+ +L + D+V I+ PL E T + N+E++ MKK I++N
Sbjct: 222 LQINPELEKEIGAKFEEDLDAMLPKCDVVVINTPLTEKTRGMFNKEKIAKMKKGVIIVNN 281
Query: 232 SRGAVVDTNALVKALEEGWIAGAGLDVYEEEPLPKDHPLTKFDNVVLTPHIGASTVEAQE 291
+RGA++DT A+ A G IAG G DV+ +P PKDHP N +TPHI +T++AQ
Sbjct: 282 ARGAIMDTQAVADACSSGHIAGYGGDVWFPQPAPKDHPWRYMPNHAMTPHISGTTIDAQL 341
Query: 292 RAGVEVAEKVVKILKG 307
R V + + + KG
Sbjct: 342 RYAAGVKDMLDRYFKG 357
>gb|AAD51414.1|AF171236_1 (AF171236) 3-phosphoglycerate dehydrogenase [Homo sapiens]
Length = 405
Score = 159 bits (398), Expect = 4e-38
Identities = 81/182 (44%), Positives = 115/182 (62%), Gaps = 1/182 (0%)
Query: 126 REGVWAKKQAMGIELEGKTLGIIGFGRIGYQVAKIARALGMNLLLYDPYPNEERAKEVGG 185
++G W +K+ MG EL GKTLGI+G GRIG +VA ++ GM + YDP + E + G
Sbjct: 1 KDGKWERKKFMGTELNGKTLGILGLGRIGREVATRMQSFGMKTIGYDPIISPEVSASFGV 60
Query: 186 KFVDLETLLRESDIVTIHVPLLESTYHLINEERLKLMKKSAILINTSRGAVVDTNALVKA 245
+ + LE + D +T+H PLL ST L+N+ KK ++N +RG +VD AL++A
Sbjct: 61 QQLPLEEIWPLCDFITVHTPLLPSTTGLLNDNTFAQCKKGVRVVNCARGGIVDEGALLRA 120
Query: 246 LEEGWIAGAGLDVYEEEPLPKDHPLTKFDNVVLTPHIGASTVEAQERAGVEVAEKVVKIL 305
L+ G AGA LDV+ EEP P+D L +NV+ PH+GAST EAQ R G E+A + V ++
Sbjct: 121 LQSGQCAGAALDVFTEEP-PRDRALVDHENVISCPHLGASTKEAQSRCGEEIAVQFVDMV 179
Query: 306 KG 307
KG
Sbjct: 180 KG 181
>pir||T42743 hypothetical protein - fission yeast (Schizosaccharomyces pombe)
>gi|1749578|dbj|BAA13847.1| (D89185) similar to
Saccharomyces cerevisiae ORF YNL274C, EMBL Accession
Number Z71550 [Schizosaccharomyces pombe]
Length = 334
Score = 159 bits (397), Expect = 5e-38
Identities = 87/227 (38%), Positives = 135/227 (59%), Gaps = 4/227 (1%)
Query: 65 PKLKVIARAGVGLDNIDVEAAKERGIEVVNAPAASSRSVAELAVALMFAVARKIAFADRK 124
P +K I G G + +DV A RGI+V + P A + A++ + LM R +
Sbjct: 79 PSVKFICHLGAGYETVDVAACTARGIQVSHVPKAVDDATADVGIFLMLGALRGFNQGIFE 138
Query: 125 MREGVWAKKQAMGIELEGKTLGIIGFGRIGYQVAKIARALGMNLLLYDPYPNEERAKEVG 184
+ + W + EGKTLGI+G G IG +AK ARA M ++ ++ P E E G
Sbjct: 139 LHKNNWNANCKPSHDPEGKTLGILGLGGIGKTMAKRARAFDMKIVYHNRTPLPEEEAE-G 197
Query: 185 GKFVDLETLLRESDIVTIHVPLLESTYHLINEERLKLMKKSAILINTSRGAVVDTNALVK 244
+FV + LL +SD++++++PL T H+I + + MK+ +++NT+RGAV+D ALV+
Sbjct: 198 AEFVSFDDLLAKSDVLSLNLPLNAHTRHIIGKPEFQKMKRGIVIVNTARGAVMDEAALVE 257
Query: 245 ALEEGWIAGAGLDVYEEEPLPKDHP-LTKFDNVVLTPHIGASTVEAQ 290
AL+EG + AGLDV+EEE PK HP L + + V+L PH+G +++E Q
Sbjct: 258 ALDEGIVYSAGLDVFEEE--PKIHPGLLENEKVILLPHLGTNSLETQ 302
>pir||T41705 probable 2-hydroxyacid dehydrogenase - fission yeast
(Schizosaccharomyces pombe) >gi|3395556|emb|CAA20140.1|
(AL031180) putative 2-hydroxyacid dehydrogenase
[Schizosaccharomyces pombe]
Length = 334
Score = 159 bits (397), Expect = 5e-38
Identities = 87/227 (38%), Positives = 135/227 (59%), Gaps = 4/227 (1%)
Query: 65 PKLKVIARAGVGLDNIDVEAAKERGIEVVNAPAASSRSVAELAVALMFAVARKIAFADRK 124
P +K I G G + +DV A RGI+V + P A + A++ + LM R +
Sbjct: 79 PSVKFICHLGAGYETVDVAACTARGIQVSHVPKAVDDATADVGIFLMLGALRGFNQGIFE 138
Query: 125 MREGVWAKKQAMGIELEGKTLGIIGFGRIGYQVAKIARALGMNLLLYDPYPNEERAKEVG 184
+ + W + EGKTLGI+G G IG +AK ARA M ++ ++ P E E G
Sbjct: 139 LHKNNWNANCKPSHDPEGKTLGILGLGGIGKTMAKRARAFDMKIVYHNRTPLPEEEAE-G 197
Query: 185 GKFVDLETLLRESDIVTIHVPLLESTYHLINEERLKLMKKSAILINTSRGAVVDTNALVK 244
+FV + LL +SD++++++PL T H+I + + MK+ +++NT+RGAV+D ALV+
Sbjct: 198 AEFVSFDDLLAKSDVLSLNLPLNAHTRHIIGKPEFQKMKRGIVIVNTARGAVMDEAALVE 257
Query: 245 ALEEGWIAGAGLDVYEEEPLPKDHP-LTKFDNVVLTPHIGASTVEAQ 290
AL+EG + AGLDV+EEE PK HP L + + V+L PH+G +++E Q
Sbjct: 258 ALDEGIVYSAGLDVFEEE--PKIHPGLLENEKVILLPHLGTNSLETQ 302
>dbj|BAA25287.1| (AB011840) CtBP [Drosophila melanogaster]
Length = 383
Score = 158 bits (396), Expect = 7e-38
Identities = 98/259 (37%), Positives = 142/259 (53%), Gaps = 14/259 (5%)
Query: 56 VTRKVIESAPKLKVIARAGVGLDNIDVEAAKERGIEVVNAPAASSRSVAELAVALMFAVA 115
+T++ +E L++I R G G DNIDV+AA E GI V N P VA+ + L+ +
Sbjct: 81 LTKEDLEKFKALRIIVRIGSGTDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLY 140
Query: 116 RKIAFADRKMREGV------WAKKQAMGI-ELEGKTLGIIGFGRIGYQVAKIARALGMNL 168
R+ + +REG ++ A G + G TLG++G GRIG VA A+A G N+
Sbjct: 141 RRTYWLANMVREGKKFTGPEQVREAAHGCARIRGDTLGLVGLGRIGSAVALRAKAFGFNV 200
Query: 169 LLYDPYPNEERAKEVG-GKFVDLETLLRESDIVTIHVPLLESTYHLINEERLKLMKKSAI 227
+ YDPY + K +G + L+ LL +SD V++H L E +HLINE +K M+ A
Sbjct: 201 IFYDPYLPDGIDKSLGLTRVYTLQDLLFQSDCVSLHCTLNEHNHHLINEFTIKQMRPGAF 260
Query: 228 LINTSRGAVVDTNALVKALEEGWIAGAGLDVYEEEPLPKDHPLTKFDNVVLTPHIG---- 283
L+NT+RG +VD L AL++G I A LDV+E EP + L N++ TPH
Sbjct: 261 LVNTARGGLVDDETLALALKQGRIRAAALDVHENEPY--NGALKDAPNLICTPHAAFFSD 318
Query: 284 ASTVEAQERAGVEVAEKVV 302
AS E +E A E+ +V
Sbjct: 319 ASATELREMAATEIRRAIV 337
>pir||C70645 hypothetical protein Rv0728c - Mycobacterium tuberculosis (strain
H37RV) >gi|3261700|emb|CAB06474.1| (Z84395) hypothetical
protein Rv0728c [Mycobacterium tuberculosis]
Length = 326
Score = 158 bits (396), Expect = 7e-38
Identities = 104/318 (32%), Positives = 166/318 (51%), Gaps = 26/318 (8%)
Query: 5 KVLVAAPLHEKAIQILKDAGLEVIYEEYPEE--------DRLVELVKDVEA-IIVRSKPK 55
+ LV APL L+ +V+Y+ + ++ ++L + + V A ++V
Sbjct: 6 RALVTAPLRGPGFAQLRRLA-DVVYDPWIDQRPLRIYSAEQLADRITAVAADVLVVESDS 64
Query: 56 VTRKVIESAPKLKVIARAGVGLDNIDVEAAKERGIEVVNAPAASSRSVAELAVALMFAVA 115
V V E L+V+A N+D+ A GI V++ PA ++ +VAE+ VAL+ AVA
Sbjct: 65 VGGPVFERG--LRVVAATRGDPSNVDIPGATAAGIPVLHTPARNADAVAEMTVALLLAVA 122
Query: 116 RKIAFADRKMR------EGVWAKKQAMGIELEGKTLGIIGFGRIGYQVAKIARALGMNLL 169
R + AD +R +G ++ G E+ G T G++G G +G V LG+ ++
Sbjct: 123 RHLIPADADVRSGNIFRDGTIPYQRFRGAEIAGLTAGLVGLGAVGRAVRWRLSGLGLRVI 182
Query: 170 LYDPYPNEERAKEVGGKFVDLETLLRESDIVTIHVPLLESTYHLINEERLKLMKKSAILI 229
+DPY ++ L+ LL E+DIV++H + + T +I ++ M+ A+ +
Sbjct: 183 AHDPYRDDAGHS--------LDELLAEADIVSMHAAVTDDTIGMIGAQQFAAMRDGAVFL 234
Query: 230 NTSRGAVVDTNALVKALEEGWIAGAGLDVYEEEPLPKDHPLTKFDNVVLTPHIGASTVEA 289
NT+R + DT+ALV AL G +A AGLD + E LP DHPL NVVLTPHIG +T
Sbjct: 235 NTARSQLRDTDALVDALRGGKLAAAGLDHFTGEWLPTDHPLVSMPNVVLTPHIGGATWNT 294
Query: 290 QERAGVEVAEKVVKILKG 307
+ R VA+ + +L G
Sbjct: 295 EARQARMVADDLGALLSG 312
>sp|Q59642|LDHD_PEDAC D-LACTATE DEHYDROGENASE (D-LDH) >gi|897794|emb|CAA50275.1| (X70925)
D-lactate dehydrogenase [Pediococcus acidilactici]
Length = 331
Score = 158 bits (395), Expect = 9e-38
Identities = 91/259 (35%), Positives = 146/259 (56%), Gaps = 18/259 (6%)
Query: 39 VELVKDVEAIIVRSKPKVTRKVIESAPKLKVIARA--GVGLDNIDVEAAKERGIEVVNAP 96
++L KD + ++ + T + + + + A + VGLDN+ +A K+ I++ N P
Sbjct: 39 IDLAKDYDGVVAYQQKPYTADLFDKMHEFGIHAFSLRNVGLDNVPADALKKNDIKISNVP 98
Query: 97 AASSRSVAELAVALMFAVARKIAFADRKMREGVWAKKQAMGIELEGKTLGIIGFGRIGYQ 156
A S R++AEL+V + A+ RKI + KM G + + +G+EL T+G+IG GRIG
Sbjct: 99 AYSPRAIAELSVTQLLALLRKIPEFEYKMAHGDYRWEPDIGLELNQMTVGVIGTGRIGRA 158
Query: 157 VAKIARALGMNLLLYDPYPNEERAKEVGGKFVD-LETLLRESDIVTIHVPLLESTYHLIN 215
I + G ++ YD + N KE G +VD LE L ++++++T+HVP L+ YH+++
Sbjct: 159 AIDIFKPFGAKVIAYDVFRNPALEKE--GMYVDTLEELYQQANVITLHVPALKDNYHMLD 216
Query: 216 EERLKLMKKSAILINTSRGAVVDTNALVKALEEGWIAGAGLDVYEEE---------PLPK 266
E+ M+ ++N +RG +VDT AL+KAL+ G +AGA LD YE E P
Sbjct: 217 EKAFGQMQDGTFILNFARGTLVDTPALLKALDSGKVAGAALDTYENEVGIFDVDHGDQPI 276
Query: 267 DHP----LTKFDNVVLTPH 281
D P L NV++TPH
Sbjct: 277 DDPVFNDLMSRRNVMITPH 295
>pir||T50134 2-hydroxyacid dehydrogenase [imported] - fission yeast
(Schizosaccharomyces pombe) >gi|7024424|emb|CAB75871.1|
(AL157811) 2-hydroxyacid dehydrogenase
[Schizosaccharomyces pombe]
Length = 332
Score = 158 bits (395), Expect = 9e-38
Identities = 105/289 (36%), Positives = 155/289 (53%), Gaps = 26/289 (8%)
Query: 26 EVIYEEYPEEDRLVELVKDVEAIIVRSKPKVTRKVIES---APKLKVIARAGV------- 75
E + E Y E E + + + ++ K V + A LKV+A+ G
Sbjct: 17 EKVNENYKHEIDYHESILNKKTAVLAEKAPVVCVFVNDKVDADTLKVLAKNGTKLIALRC 76
Query: 76 -GLDNIDVEAAKERGIEVVNAPAASSRSVAELAVALMFAVARKIAFADRKMREGVWAKKQ 134
G +N+D++AA + GI VV PA S +VAE + L+ ++ RKI A ++RE +
Sbjct: 77 AGFNNVDLKAAADNGITVVRVPAYSPYAVAEYTIGLLLSLNRKIHRAYVRVREDDFNLNG 136
Query: 135 AMGIELEGKTLGIIGFGRIGYQVAKIAR-ALGMNLLLYDPYPNEERAKEVGGKFVDLETL 193
+G +L GKT+G++G GRIG VAK + G +L +D PN+E K G +FV+ + +
Sbjct: 137 LLGHDLHGKTIGLLGTGRIGGLVAKCLKLGFGCEVLAHDIKPNKELEK-FGIQFVEQQEV 195
Query: 194 LRESDIVTIHVPLLESTYHLINEERLKLMKKSAILINTSRGAVVDTNALVKALEEGWIAG 253
L ++D + +H PL T HL++E+ L MKK +INTSRG +VDT ALVKA+E G + G
Sbjct: 196 LAKADFLCLHCPLTPDTEHLVDEKLLASMKKGVKIINTSRGGLVDTKALVKAIESGQVGG 255
Query: 254 AGLDVYEEE----------PLPKD---HPLTKFDNVVLTPHIGASTVEA 289
+DVYE E + KD L F NV++T H T EA
Sbjct: 256 CAMDVYEGERRLFYRDLSNEVIKDTTFQQLANFPNVLVTSHQAFFTAEA 304
>emb|CAA12074.1| (AJ224690) C-terminal binding protein [Drosophila melanogaster]
Length = 386
Score = 157 bits (393), Expect = 1e-37
Identities = 100/265 (37%), Positives = 143/265 (53%), Gaps = 23/265 (8%)
Query: 56 VTRKVIESAPKLKVIARAGVGLDNIDVEAAKERGIEVVNAPAASSRSVAELAVALMFAVA 115
+T++ +E L++I R G G DNIDV+AA E GI V N P VA+ + L+ +
Sbjct: 81 LTKEDLEKFKALRIIVRIGSGTDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLY 140
Query: 116 RKIAFADRKMREGV------WAKKQAMGI-ELEGKTLGIIGFGRIGYQVAKIARALGMNL 168
R+ + +REG ++ A G + G TLG++G GRIG VA A+A G N+
Sbjct: 141 RRTYWLANMVREGKKFTGPEQVREAAHGCARIRGDTLGLVGLGRIGSAVALRAKAFGFNV 200
Query: 169 LLYDPYPNEERAKEVG-GKFVDLETLLRESDIVTIHVPLLESTYHLINEERLKLMKKSAI 227
+ YDPY + K +G + L+ LL +SD V++H L E +HLINE +K M+ A
Sbjct: 201 IFYDPYLPDGIDKSLGLTRVYTLQDLLFQSDCVSLHCTLNEHNHHLINEFTIKQMRPGAF 260
Query: 228 LINTSRGAVVDTNALVKALEEGWIAGAGLDVYEEEPLP------KDHPLTKFDNVVLTPH 281
L+NT+RG +VD L AL++G I A LDV+E EP KD P N++ TPH
Sbjct: 261 LVNTARGGLVDDETLALALKQGRIRAAALDVHENEPYNVFQGALKDAP-----NLICTPH 315
Query: 282 IG----ASTVEAQERAGVEVAEKVV 302
AS E +E A E+ +V
Sbjct: 316 AAFFSDASATELREMAATEIRRAIV 340
>gb|AAF54891.1| (AE003698) CtBP gene product [alt 2] [Drosophila melanogaster]
>gi|7299710|gb|AAF54892.1| (AE003698) CtBP gene product
[alt 1] [Drosophila melanogaster]
Length = 386
Score = 157 bits (393), Expect = 1e-37
Identities = 100/265 (37%), Positives = 143/265 (53%), Gaps = 23/265 (8%)
Query: 56 VTRKVIESAPKLKVIARAGVGLDNIDVEAAKERGIEVVNAPAASSRSVAELAVALMFAVA 115
+T++ +E L++I R G G DNIDV+AA E GI V N P VA+ + L+ +
Sbjct: 81 LTKEDLEKFKALRIIVRIGSGTDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLY 140
Query: 116 RKIAFADRKMREGV------WAKKQAMGI-ELEGKTLGIIGFGRIGYQVAKIARALGMNL 168
R+ + +REG ++ A G + G TLG++G GRIG VA A+A G N+
Sbjct: 141 RRTYWLANMVREGKKFTGPEQVREAAHGCARIRGDTLGLVGLGRIGSAVALRAKAFGFNV 200
Query: 169 LLYDPYPNEERAKEVG-GKFVDLETLLRESDIVTIHVPLLESTYHLINEERLKLMKKSAI 227
+ YDPY + K +G + L+ LL +SD V++H L E +HLINE +K M+ A
Sbjct: 201 IFYDPYLPDGIDKSLGLTRVYTLQDLLFQSDCVSLHCTLNEHNHHLINEFTIKQMRPGAF 260
Query: 228 LINTSRGAVVDTNALVKALEEGWIAGAGLDVYEEEPLP------KDHPLTKFDNVVLTPH 281
L+NT+RG +VD L AL++G I A LDV+E EP KD P N++ TPH
Sbjct: 261 LVNTARGGLVDDETLALALKQGRIRAAALDVHENEPYNVFQGALKDAP-----NLICTPH 315
Query: 282 IG----ASTVEAQERAGVEVAEKVV 302
AS E +E A E+ +V
Sbjct: 316 AAFFSDASATELREMAATEIRRAIV 340
>pir||T51423 formate dehydrogenase (FDH) - Arabidopsis thaliana
>gi|6625953|gb|AAF19435.1|AF208028_1 (AF208028)
NAD-dependent formate dehydrogenase 1A [Arabidopsis
thaliana] >gi|6625955|gb|AAF19436.1|AF208029_1
(AF208029) NAD-dependent formate dehydrogenase 1B
[Arabidopsis thaliana] >gi|6681408|dbj|BAA88683.1|
(AB023897) formate dehydrogenase [Arabidopsis thaliana]
>gi|7677266|gb|AAF67100.1|AF217195_1 (AF217195) formate
dehydrogenase [Arabidopsis thaliana]
>gi|9755746|emb|CAC01877.1| (AL391149) formate
dehydrogenase (FDH) [Arabidopsis thaliana]
Length = 384
Score = 157 bits (392), Expect = 2e-37
Identities = 89/256 (34%), Positives = 142/256 (54%), Gaps = 4/256 (1%)
Query: 56 VTRKVIESAPKLKVIARAGVGLDNIDVEAAKERGIEVVNAPAASSRSVAELAVALMFAVA 115
VT + I+ A LK++ AG+G D+ID++AA G+ V ++ SVAE + + +
Sbjct: 109 VTAERIKKAKNLKLLLTAGIGSDHIDLQAAAAAGLTVAEVTGSNVVSVAEDELMRILILM 168
Query: 116 RKIAFADRKMREGVW--AKKQAMGIELEGKTLGIIGFGRIGYQVAKIARALGMNLLLYDP 173
R ++ +G W A +LEGKT+G +G GRIG + + + G NLL +D
Sbjct: 169 RNFVPGYNQVVKGEWNVAGIAYRAYDLEGKTIGTVGAGRIGKLLLQRLKPFGCNLLYHDR 228
Query: 174 YPNE-ERAKEVGGKFV-DLETLLRESDIVTIHVPLLESTYHLINEERLKLMKKSAILINT 231
E KE G KFV DL +L + D++ I++PL E T + N+E + +KK +++N
Sbjct: 229 LQMAPELEKETGAKFVEDLNEMLPKCDVIVINMPLTEKTRGMFNKELIGKLKKGVLIVNN 288
Query: 232 SRGAVVDTNALVKALEEGWIAGAGLDVYEEEPLPKDHPLTKFDNVVLTPHIGASTVEAQE 291
+RGA+++ A+V A+E G I G DV++ +P PKDHP N +TPH +T++AQ
Sbjct: 289 ARGAIMERQAVVDAVESGHIGGYSGDVWDPQPAPKDHPWRYMPNQAMTPHTSGTTIDAQL 348
Query: 292 RAGVEVAEKVVKILKG 307
R + + + KG
Sbjct: 349 RYAAGTKDMLERYFKG 364
>gb|AAF79644.1|AC025416_18 (AC025416) F5O11.29 [Arabidopsis thaliana]
>gi|9502370|gb|AAF88077.1|AC025417_5 (AC025417) T12C24.9
[Arabidopsis thaliana]
Length = 323
Score = 157 bits (392), Expect = 2e-37
Identities = 88/243 (36%), Positives = 143/243 (58%), Gaps = 8/243 (3%)
Query: 47 AIIVRSKPKVTRKVIESAPKLKVIARAGVGLDNIDVEAAKERGIEVVNAPAASSRSVAEL 106
A ++ + VT +++ P L+++ VG+D+ID+ A K RGI + NA A S VA+
Sbjct: 55 AFVISGRLPVTDELLSHLPSLQILVCTSVGIDHIDLAACKRRGIVITNAGNAFSDDVADC 114
Query: 107 AVALMFAVARKIAFADRKMREGVWAK--KQAMGIELEGKTLGIIGFGRIGYQVAKIARAL 164
AV L+ +V R+I ADR +R G WAK +G ++ GK +GI+G G IG VAK +
Sbjct: 115 AVGLLISVLRRIPAADRYVRSGNWAKFGDFQLGSKVSGKRVGIVGLGSIGSFVAKRLESF 174
Query: 165 GMNLLLYDPYPNEERAKEVGGKFVDLETLLRESDIVTIHVPLLESTYHLINEERLKLMKK 224
G ++ Y+ ++ + D+ +L +D++ + L + T+H++N E ++L+ K
Sbjct: 175 GC-VISYN--SRSQKQSSPYRYYSDILSLAENNDVLVLCCSLTDETHHIVNREVMELLGK 231
Query: 225 SAILINTSRGAVVDTNALVKALEEGWIAGAGLDVYEEEP-LPKDHPLTKFDNVVLTPHIG 283
++IN RG ++D +VK L +G I GAGLDV+E EP +P++ L DNVVL+PH
Sbjct: 232 DGVVINVGRGKLIDEKEMVKCLVDGVIGGAGLDVFENEPAVPQE--LFGLDNVVLSPHFA 289
Query: 284 AST 286
+T
Sbjct: 290 VAT 292
>sp|Q07511|FDH_SOLTU MITOCHONDRIAL FORMATE DEHYDROGENASE PRECURSOR (NAD-DEPENDENT
FORMATE DEHYDROGENASE) (FDH) >gi|542089|pir||JQ2272
formate dehydrogenase (EC 1.2.1.2) precursor,
mitochondrial - potato >gi|297798|emb|CAA79702.1|
(Z21493) mitochondrial formate dehydrogenase precursor
[Solanum tuberosum]
Length = 379
Score = 156 bits (391), Expect = 3e-37
Identities = 88/256 (34%), Positives = 142/256 (55%), Gaps = 4/256 (1%)
Query: 56 VTRKVIESAPKLKVIARAGVGLDNIDVEAAKERGIEVVNAPAASSRSVAELAVALMFAVA 115
VT + I+ A L+++ AG+G D++D++AA G+ V +++ SVAE + + +
Sbjct: 104 VTAERIKKAKNLQLLLTAGIGSDHVDLKAAAAAGLTVAEVTGSNTVSVAEDELMRILILV 163
Query: 116 RKIAFADRKMREGVW--AKKQAMGIELEGKTLGIIGFGRIGYQVAKIARALGMNLLLYDP 173
R ++ G W A +LEGKT+G +G GRIG + + + NLL +D
Sbjct: 164 RNFLPGHHQVINGEWNVAAIAHRAYDLEGKTVGTVGAGRIGRLLLQRLKPFNCNLLYHDR 223
Query: 174 YP-NEERAKEVGGKFV-DLETLLRESDIVTIHVPLLESTYHLINEERLKLMKKSAILINT 231
+ E ++G KF DL+ +L + DIV I+ PL E T + ++ER+ +KK +++N
Sbjct: 224 LKMDSELENQIGAKFEEDLDKMLSKCDIVVINTPLTEKTKGMFDKERIAKLKKGVLIVNN 283
Query: 232 SRGAVVDTNALVKALEEGWIAGAGLDVYEEEPLPKDHPLTKFDNVVLTPHIGASTVEAQE 291
+RGA++DT A+V A G IAG DV+ +P PKDHP N +TPHI +T++AQ
Sbjct: 284 ARGAIMDTQAVVDACNSGHIAGYSGDVWYPQPAPKDHPWRYMPNQAMTPHISGTTIDAQL 343
Query: 292 RAGVEVAEKVVKILKG 307
R + + + KG
Sbjct: 344 RYAAGTKDMLDRYFKG 359
>gi|6912396 glyoxylate reductase/hydroxypyruvate reductase [Homo sapiens]
>gi|11428924|ref|XP_005487.1| glyoxylate
reductase/hydroxypyruvate reductase [Homo sapiens]
>gi|5639830|gb|AAD45886.1|AF146018_1 (AF146018)
hydroxypyruvate reductase [Homo sapiens]
>gi|5669919|gb|AAD46517.1|AF146689_1 (AF146689)
hydroxypyruvate reductase [Homo sapiens]
>gi|6002730|gb|AAF00111.1|AF134895_1 (AF134895)
glyoxylate reductase [Homo sapiens]
Length = 328
Score = 155 bits (388), Expect = 6e-37
Identities = 91/257 (35%), Positives = 143/257 (55%), Gaps = 5/257 (1%)
Query: 56 VTRKVIESA-PKLKVIARAGVGLDNIDVEAAKERGIEVVNAPAASSRSVAELAVALMFAV 114
V ++++++A LKVI+ VG+D++ ++ K+RGI V P + + AELAV+L+
Sbjct: 63 VDKRILDAAGANLKVISTMSVGIDHLALDEIKKRGIRVGYTPDVLTDTTAELAVSLLLTT 122
Query: 115 ARKIAFADRKMREGVWAKKQAM---GIELEGKTLGIIGFGRIGYQVAKIARALGMNLLLY 171
R++ A +++ G W + + G L T+GIIG GRIG +A+ + G+ LY
Sbjct: 123 CRRLPEAIEEVKNGGWTSWKPLWLCGYGLTQSTVGIIGLGRIGQAIARRLKPFGVQRFLY 182
Query: 172 DP-YPNEERAKEVGGKFVDLETLLRESDIVTIHVPLLESTYHLINEERLKLMKKSAILIN 230
P E A E +FV L +SD + + L +T L N++ + MK++A+ IN
Sbjct: 183 TGRQPRPEEAAEFQAEFVSTPELAAQSDFIVVACSLTPATEGLCNKDFFQKMKETAVFIN 242
Query: 231 TSRGAVVDTNALVKALEEGWIAGAGLDVYEEEPLPKDHPLTKFDNVVLTPHIGASTVEAQ 290
SRG VV+ + L +AL G IA AGLDV EPLP +HPL N V+ PHIG++T +
Sbjct: 243 ISRGDVVNQDDLYQALASGKIAAAGLDVTSPEPLPTNHPLLTLKNCVILPHIGSATHRTR 302
Query: 291 ERAGVEVAEKVVKILKG 307
+ A ++ L+G
Sbjct: 303 NTMSLLAANNLLAGLRG 319
>pir||S76782 D-2-hydroxy-acid dehydrogenase (EC 1.1.99.6) - Synechocystis sp.
(strain PCC 6803) >gi|1653783|dbj|BAA18694.1| (D90916)
2-hydroxyaciddehydrogenase [Synechocystis sp.]
Length = 333
Score = 155 bits (387), Expect = 7e-37
Identities = 93/264 (35%), Positives = 146/264 (55%), Gaps = 15/264 (5%)
Query: 41 LVKDVEAIIVRSKPKVTRKVIE--SAPKLKVIARAGVGLDNIDVEAAKERGIEVVNAPAA 98
L +D I + + V+E +A K+IA G +N+D++ A + G++VV+ P+
Sbjct: 41 LAEDCPVICLFVNDQAPAPVLEKLAAQGTKLIALRSAGYNNVDLKTAADLGLKVVHVPSY 100
Query: 99 SSRSVAELAVALMFAVARKIAFADRKMREGVWAKKQAMGIELEGKTLGIIGFGRIGYQVA 158
S +VAE V L+ A+ RK+ A ++R+ ++ + +G +L G T+G+IG G+IG A
Sbjct: 101 SPHAVAEHTVGLILALNRKLYRAYNRVRDDNFSLEGLLGFDLHGTTVGVIGTGKIGLAFA 160
Query: 159 KIARALGMNLLLYDPYPNEERAKEVGGKFVDLETLLRESDIVTIHVPLLESTYHLINEER 218
+I G +LL YD +PN++ +V L LL SDI+++H PLL T++LIN
Sbjct: 161 QIMNGFGCHLLGYDAFPNDKFTAIGQALYVSLNELLAHSDIISLHCPLLPETHYLINTNT 220
Query: 219 LKLMKKSAILINTSRGAVVDTNALVKALEEGWIAGAGLDVYEEEP--LPKDHP------- 269
+ MK +LINTSRG ++DT A+++ ++ I G+DVYEEE DH
Sbjct: 221 IAQMKPGVMLINTSRGHLIDTQAVIQGIKSHKIGFLGIDVYEEEEELFFTDHSDTIIQDD 280
Query: 270 ----LTKFDNVVLTPHIGASTVEA 289
L F NV++T H G T A
Sbjct: 281 TFQLLQSFPNVMITAHQGFFTHNA 304
>pir||S68164 glycerate dehydrogenase (EC 1.1.1.29) splice form HPR1, microbody -
cucurbit >gi|1304042|dbj|BAA08410.1| (D49432)
hydroxypyruvate reductase [Cucurbita sp.]
Length = 386
Score = 154 bits (385), Expect = 1e-36
Identities = 97/259 (37%), Positives = 144/259 (55%), Gaps = 21/259 (8%)
Query: 68 KVIARAGVGLDNIDVEAAKERGIEVVNAPAASSRSVAELAVALMFAVARKIAFADRKMRE 127
K + VG +N+DV AA + GI V N P + + AELA +L A AR+I AD MR
Sbjct: 88 KAFSNMAVGYNNVDVNAANKYGIAVGNTPGVLTETTAELAASLSLAAARRIVEADEFMRA 147
Query: 128 GV---WAKKQAMGIELEGKTLGIIGFGRIGYQVAKI-ARALGMNLLLYDPYPNEERAKEV 183
G W +G L+G+T+G+IG GRIG A++ MNL+ +D Y + K V
Sbjct: 148 GHYDGWLPNLFVGNLLKGQTVGVIGAGRIGSAYARMMVEGFKMNLIYFDLYQSTRLEKFV 207
Query: 184 G--GKFV--------------DLETLLRESDIVTIHVPLLESTYHLINEERLKLMKKSAI 227
G+F+ ++ +LRE+D++++H L ++T+HL+N+E LK MKK AI
Sbjct: 208 TAYGEFLKANGEVPVTWRRASSMDEVLREADVISLHPVLDKTTFHLVNKESLKAMKKDAI 267
Query: 228 LINTSRGAVVDTNALVKALEEGWIAGAGLDVYEEEPLPKDHPLTKFDNVVLTPHIGASTV 287
LIN SRG V+D ALV+ L+E + GLDV+E+EP K L N ++ PHI +++
Sbjct: 268 LINCSRGPVIDEAALVEHLKENPMFRVGLDVFEDEPYMKP-GLADMKNAIIVPHIASASK 326
Query: 288 EAQERAGVEVAEKVVKILK 306
+E A V+ +K
Sbjct: 327 WTREGMATLAALNVLGKIK 345
>pir||S68165 glycerate dehydrogenase (EC 1.1.1.29) splice form HPR2 - cucurbit
>gi|1304044|dbj|BAA08411.1| (D49433) hydroxypyruvate
reductase [Cucurbita sp.]
Length = 381
Score = 154 bits (385), Expect = 1e-36
Identities = 97/259 (37%), Positives = 144/259 (55%), Gaps = 21/259 (8%)
Query: 68 KVIARAGVGLDNIDVEAAKERGIEVVNAPAASSRSVAELAVALMFAVARKIAFADRKMRE 127
K + VG +N+DV AA + GI V N P + + AELA +L A AR+I AD MR
Sbjct: 88 KAFSNMAVGYNNVDVNAANKYGIAVGNTPGVLTETTAELAASLSLAAARRIVEADEFMRA 147
Query: 128 GV---WAKKQAMGIELEGKTLGIIGFGRIGYQVAKI-ARALGMNLLLYDPYPNEERAKEV 183
G W +G L+G+T+G+IG GRIG A++ MNL+ +D Y + K V
Sbjct: 148 GHYDGWLPNLFVGNLLKGQTVGVIGAGRIGSAYARMMVEGFKMNLIYFDLYQSTRLEKFV 207
Query: 184 G--GKFV--------------DLETLLRESDIVTIHVPLLESTYHLINEERLKLMKKSAI 227
G+F+ ++ +LRE+D++++H L ++T+HL+N+E LK MKK AI
Sbjct: 208 TAYGEFLKANGEVPVTWRRASSMDEVLREADVISLHPVLDKTTFHLVNKESLKAMKKDAI 267
Query: 228 LINTSRGAVVDTNALVKALEEGWIAGAGLDVYEEEPLPKDHPLTKFDNVVLTPHIGASTV 287
LIN SRG V+D ALV+ L+E + GLDV+E+EP K L N ++ PHI +++
Sbjct: 268 LINCSRGPVIDEAALVEHLKENPMFRVGLDVFEDEPYMKP-GLADMKNAIIVPHIASASK 326
Query: 288 EAQERAGVEVAEKVVKILK 306
+E A V+ +K
Sbjct: 327 WTREGMATLAALNVLGKIK 345
>sp|P13443|DHGY_CUCSA GLYCERATE DEHYDROGENASE (NADH-DEPENDENT HYDROXYPYRUVATE REDUCTASE)
(HPR) (GDH) >gi|65955|pir||DEKVG glycerate dehydrogenase
(EC 1.1.1.29) - cucumber >gi|18264|emb|CAA41434.1|
(X58542) NADH-dependent hydroxypyruvate reductase
[Cucumis sativus] >gi|18275|emb|CAA32764.1| (X14609)
NAPH-dependent hydroxypyruvate reductase (AA 1 - 382)
[Cucumis sativus]
Length = 382
Score = 153 bits (384), Expect = 2e-36
Identities = 96/260 (36%), Positives = 143/260 (54%), Gaps = 21/260 (8%)
Query: 68 KVIARAGVGLDNIDVEAAKERGIEVVNAPAASSRSVAELAVALMFAVARKIAFADRKMRE 127
K + VG +N+DV AA + G+ V N P + + AELA +L A AR+I AD MR
Sbjct: 88 KAFSNMAVGYNNVDVNAANKYGVAVGNTPGVLTETTAELAASLSLAAARRIVEADEFMRA 147
Query: 128 GV---WAKKQAMGIELEGKTLGIIGFGRIGYQVAKI-ARALGMNLLLYDPYPNEERAKEV 183
G W +G L+G+T+G+IG GRIG A++ MNL+ +D Y + K V
Sbjct: 148 GRYDGWLPNLFVGNLLKGQTVGVIGAGRIGSAYARMMVEGFKMNLIYFDLYQSTRLEKFV 207
Query: 184 G--GKFV--------------DLETLLRESDIVTIHVPLLESTYHLINEERLKLMKKSAI 227
G+F+ ++ +LRE+D++++H L ++T+HL+N+E LK MKK AI
Sbjct: 208 TAYGEFLKANGEAPVTWRRASSMDEVLREADVISLHPVLDKTTFHLVNKESLKAMKKDAI 267
Query: 228 LINTSRGAVVDTNALVKALEEGWIAGAGLDVYEEEPLPKDHPLTKFDNVVLTPHIGASTV 287
LIN SRG V+D ALV L + + GLDV+E+EP K L N ++ PHI +++
Sbjct: 268 LINCSRGPVIDEAALVDHLRDNPMFRVGLDVFEDEPYMKP-GLADMKNAIIVPHIASASK 326
Query: 288 EAQERAGVEVAEKVVKILKG 307
+E A V+ +KG
Sbjct: 327 WTREGMATLAALNVLGKIKG 346
>gi|6324055 Ynl274cp [Saccharomyces cerevisiae]
>gi|1730640|sp|P53839|YN14_YEAST HYPOTHETICAL 38.8 KD
PROTEIN IN MET2-SEC2 INTERGENIC REGION
>gi|2131951|pir||S63248 hypothetical protein YNL274c -
yeast (Saccharomyces cerevisiae)
>gi|1302340|emb|CAA96182.1| (Z71550) ORF YNL274c
[Saccharomyces cerevisiae]
Length = 350
Score = 153 bits (384), Expect = 2e-36
Identities = 86/242 (35%), Positives = 131/242 (53%), Gaps = 8/242 (3%)
Query: 70 IARAGVGLDNIDVEAAKERGIEVVNAPAASSRSVAELAVALMFAVARKIAFADRKMREGV 129
+ G G D IDVE K+R I+V N P S + A+ V L+ R +R++ EG
Sbjct: 86 VCHTGAGYDQIDVEPFKKRHIQVANVPDLVSNATADTHVFLLLGALRNFGIGNRRLIEGN 145
Query: 130 WAKK-----QAMGIELEGKTLGIIGFGRIGYQVAKIARALGMNLLLYDPYPNEERAKEVG 184
W + G + EGKT+GI+G GRIG + + + G +Y +E G
Sbjct: 146 WPEAGPACGSPFGYDPEGKTVGILGLGRIGRCILERLKPFGFENFIYHNRHQLPSEEEHG 205
Query: 185 GKFVDLETLLRESDIVTIHVPLLESTYHLINEERLKLMKKSAILINTSRGAVVDTNALVK 244
++V E L+ SDIV+++VPL +T+HLIN E ++ MK +++NT+RGAV+D A+
Sbjct: 206 CEYVGFEEFLKRSDIVSVNVPLNHNTHHLINAETIEKMKDGVVIVNTARGAVIDEQAMTD 265
Query: 245 ALEEGWIAGAGLDVYEEEP-LPKDHPLTKFDNVVLTPHIGASTVEAQERAGVEVAEKVVK 303
AL G I AGLDV+E EP + K+ L V+ PH+G +VE +++ V E
Sbjct: 266 ALRSGKIRSAGLDVFEYEPKISKE--LLSMSQVLGLPHMGTHSVETRKKMEELVVENAKN 323
Query: 304 IL 305
++
Sbjct: 324 VI 325
>dbj|BAA77337.1| (AB019533) Nad-dependent formate dehydrogenase [Oryza sativa]
Length = 376
Score = 152 bits (381), Expect = 4e-36
Identities = 88/256 (34%), Positives = 142/256 (55%), Gaps = 4/256 (1%)
Query: 56 VTRKVIESAPKLKVIARAGVGLDNIDVEAAKERGIEVVNAPAASSRSVAELAVALMFAVA 115
V+ + I+ A L+++ AG+G D+ID+ AA G+ V +++ SVAE + + +
Sbjct: 101 VSAERIKKAKNLELLLTAGIGSDHIDLPAAAAAGLTVAEVTGSNTVSVAEDELMRILILL 160
Query: 116 RKIAFADRKMREGVW--AKKQAMGIELEGKTLGIIGFGRIGYQVAKIARALGMNLLLYDP 173
R +++ G W A +LEGKT+G +G GRIG + + + NLL +D
Sbjct: 161 RNFLPGYQQVVHGEWNVAGIAYRAYDLEGKTVGTVGAGRIGRLLLQRLKPFNCNLLYHDR 220
Query: 174 YP-NEERAKEVGGKFV-DLETLLRESDIVTIHVPLLESTYHLINEERLKLMKKSAILINT 231
+ E KE+G K+ DL+ +L + D++ I+ PL E T + N+ER+ MKK I++N
Sbjct: 221 LKIDPELEKEIGAKYEEDLDAMLPKCDVIVINTPLTEKTRGMFNKERIAKMKKGVIIVNN 280
Query: 232 SRGAVVDTNALVKALEEGWIAGAGLDVYEEEPLPKDHPLTKFDNVVLTPHIGASTVEAQE 291
+RGA++DT A+ A G +AG G DV+ +P PK P N +TPHI +T++AQ
Sbjct: 281 ARGAIMDTQAVADACSSGQVAGYGGDVWFPQPAPKGPPWRYMPNHAMTPHISGTTIDAQL 340
Query: 292 RAGVEVAEKVVKILKG 307
R V + + + KG
Sbjct: 341 RYAAGVKDMLDRYFKG 356
>sp|P36234|DHGY_HYPME GLYCERATE DEHYDROGENASE (NADH-DEPENDENT HYDROXYPYRUVATE REDUCTASE)
(HPR) (GDH) (HYDROXYPYRUVATE DEHYDROGENASE) (GLYOXYLATE
REDUCTASE)
Length = 322
Score = 152 bits (379), Expect = 6e-36
Identities = 94/299 (31%), Positives = 165/299 (54%), Gaps = 9/299 (3%)
Query: 1 MIEVKVLVAAPLHEKAIQILKDAGLEVIYEEYPEE--DRLVELVKDVEAIIVRSKPKVTR 58
M + K+L+ PL E A+ +++ + + + P+ D ++E K V+A+++ K +
Sbjct: 1 MSKKKILITWPLPEAAMARARESYDVIAHGDDPKITIDEMIETAKSVDALLITLNEKCRK 60
Query: 59 KVIESAPK-LKVIARAGVGLDNIDVEAAKERGIEVVNAPAASSRSVAELAVALMFAVARK 117
+VI+ P+ +K I+ +G D+ID++A K RGI+V NAP + + AE+A+ L+ AR+
Sbjct: 61 EVIDRIPENIKCISTYSIGFDHIDLDACKARGIKVGNAPHGVTVATAEIAMLLLLGSARR 120
Query: 118 IAFADRKMREGVWA---KKQAMGIELEGKTLGIIGFGRIGYQVAKIARALGMNLLLYDPY 174
++ +R W + +G +L+ KTLGI GFG IG +AK A+ M++ +D +
Sbjct: 121 AGEGEKMIRTRSWPGWEPLELVGEKLDNKTLGIYGFGSIGQALAKRAQGFDMDIDYFDTH 180
Query: 175 --PNEERAKEVGGKFVDLETLLRESDIVTIHVPLLESTYHLINEERLKLMKKSAILINTS 232
+ + A L++LL S +++ P T + N+ +K + + AI++NT+
Sbjct: 181 RASSSDEASYQATFHDSLDSLLSVSQFFSLNAPSTPETRYFFNKATIKSLPQGAIVVNTA 240
Query: 233 RGAVVDTNALVKALEEGWIAGAGLDVYEEEPLPKDHPLTKFDNVVLTPHIGASTVEAQE 291
RG +VD +V ALE G +A AG DV+ EP + N L PHIG++ +A+E
Sbjct: 241 RGDLVDNELVVAALEAGRLAYAGFDVFAGEP-NINEGYYDLPNTFLFPHIGSAATQARE 298
>pir||T50129 2-hydroxyacid dehydrogenase homolog [imported] - fission yeast
(Schizosaccharomyces pombe) >gi|7024419|emb|CAB75866.1|
(AL157811) 2-hydroxyacid dehydrogenase homolog
[Schizosaccharomyces pombe]
Length = 332
Score = 152 bits (379), Expect = 6e-36
Identities = 93/280 (33%), Positives = 155/280 (55%), Gaps = 17/280 (6%)
Query: 26 EVIYEEYPEEDRLVELVKDVEAIIVRSKPKVTRKVIESAPK--LKVIARAGVGLDNIDVE 83
E+IY + V L + + V +V +++ + +K++A G +N++++
Sbjct: 26 EIIYHNFSLNKDTVSLAGKAQVVCVFVNDQVDADTLKALAENGVKLVALRCGGYNNVNLK 85
Query: 84 AAKERGIEVVNAPAASSRSVAELAVALMFAVARKIAFADRKMREGVWAKKQAMGIELEGK 143
AA E I VV+ P+ S +V+E V L+ ++ RKI A ++RE + +G ++ GK
Sbjct: 86 AASEYKITVVHVPSYSPFAVSEFTVGLLLSLNRKIHRAYVRVREDDFNIVGLLGCDIHGK 145
Query: 144 TLGIIGFGRIGYQVAKIAR-ALGMNLLLYDPYPNEERAKEVGGKFVDLETLLRESDIVTI 202
T+G+IG G+IG VAK + G ++L YD P +++ + G +FV+ +L+++D + +
Sbjct: 146 TVGVIGTGKIGSNVAKCFKMGFGCDVLAYDINP-DKKLENYGVQFVEQNEVLKKADFLCL 204
Query: 203 HVPLLESTYHLINEERLKLMKKSAILINTSRGAVVDTNALVKALEEGWIAGAGLDVYEEE 262
H PL ST H++N + L LMKK ++NTSRG ++DT ALV A++ G + G +DVYE E
Sbjct: 205 HCPLTPSTTHIVNSDSLALMKKGVTIVNTSRGGLIDTKALVDAIDSGQVGGCAIDVYEGE 264
Query: 263 ----------PLPKD---HPLTKFDNVVLTPHIGASTVEA 289
+ KD L F NV++T H T EA
Sbjct: 265 RNLFYKDLSNEVIKDSTFQRLVNFPNVLVTSHQAFFTTEA 304
>pdb|1GDH|A Chain A, D-Glycerate Dehydrogenase (Apo Form) (E.C.1.1.1.29)
>gi|494036|pdb|1GDH|B Chain B, D-Glycerate Dehydrogenase
(Apo Form) (E.C.1.1.1.29)
Length = 320
Score = 151 bits (377), Expect = 1e-35
Identities = 93/295 (31%), Positives = 163/295 (54%), Gaps = 9/295 (3%)
Query: 5 KVLVAAPLHEKAIQILKDAGLEVIYEEYPEE--DRLVELVKDVEAIIVRSKPKVTRKVIE 62
K+L+ PL E A+ +++ + + + P+ D ++E K V+A+++ K ++VI+
Sbjct: 3 KILITWPLPEAAMARARESYDVIAHGDDPKITIDEMIETAKSVDALLITLNEKCRKEVID 62
Query: 63 SAPK-LKVIARAGVGLDNIDVEAAKERGIEVVNAPAASSRSVAELAVALMFAVARKIAFA 121
P+ +K I+ +G D+ID++A K RGI+V NAP + + AE+A+ L+ AR+
Sbjct: 63 RIPENIKCISTYSIGFDHIDLDACKARGIKVGNAPHGVTVATAEIAMLLLLGSARRAGEG 122
Query: 122 DRKMREGVWA---KKQAMGIELEGKTLGIIGFGRIGYQVAKIARALGMNLLLYDPY--PN 176
++ +R W + +G +L+ KTLGI GFG IG +AK A+ M++ +D + +
Sbjct: 123 EKMIRTRSWPGWEPLELVGEKLDNKTLGIYGFGSIGQALAKRAQGFDMDIDYFDTHRASS 182
Query: 177 EERAKEVGGKFVDLETLLRESDIVTIHVPLLESTYHLINEERLKLMKKSAILINTSRGAV 236
+ A L++LL S +++ P T + N+ +K + + AI++NT+RG +
Sbjct: 183 SDEASYQATFHDSLDSLLSVSQFFSLNAPSTPETRYFFNKATIKSLPQGAIVVNTARGDL 242
Query: 237 VDTNALVKALEEGWIAGAGLDVYEEEPLPKDHPLTKFDNVVLTPHIGASTVEAQE 291
VD +V ALE G +A AG DV+ EP + N L PHIG++ +A+E
Sbjct: 243 VDNELVVAALEAGRLAYAGFDVFAGEP-NINEGYYDLPNTFLFPHIGSAATQARE 296
>pir||H64531 phosphoglycerate dehydrogenase - Helicobacter pylori (strain 26695)
>gi|2313177|gb|AAD07165.1| (AE000531) phosphoglycerate
dehydrogenase [Helicobacter pylori 26695]
Length = 314
Score = 151 bits (377), Expect = 1e-35
Identities = 105/289 (36%), Positives = 162/289 (55%), Gaps = 22/289 (7%)
Query: 6 VLVAAPLHEKAIQILKDAGLEVIYEEYPEEDRLVELVKDVEA-IIVRSKPKVTRKVIESA 64
+L A + KA+++LK+ YE P ++VE + +EA I+V +K +T++V+
Sbjct: 9 ILDAKSVGLKALEVLKEVADFDFYEVTPPS-QIVE--RSIEAEIMVLNKVVITQEVLSQL 65
Query: 65 PKLKVIARAGVGLDNIDVEAAKERGIEVVNAPAASSRSVAELAVALMFAVARKIAFADRK 124
PKLK+I G DN+D+++AK GIEV N A S+ SVA+ +A ++ +I DR
Sbjct: 66 PKLKLICITATGTDNVDIKSAKALGIEVKNVSAYSTESVAQHTLACALSLLGRINDYDRY 125
Query: 125 MREGVWAKKQ--------AMGIELEGKTLGIIGFGRIGYQVAKIARALGMNLLLYDPYPN 176
+ G +++ MG+ ++G G+IG G IG +VAK+A+A G ++ Y P
Sbjct: 126 CKSGEYSQSDLFTHISDIKMGL-IKGSQWGVIGLGTIGKRVAKLAQAFGAKVVYYSPKDK 184
Query: 177 EERAKEVGGKFVDLETLLRESDIVTIHVPLLESTYHLINEERLKLMKKSAILINTSRGAV 236
+E + + L+ LL SDI++IH PL EST LI + L+ +K AILIN RG +
Sbjct: 185 KEEYER-----LSLKDLLATSDIISIHAPLNESTRDLIALKELQSLKDGAILINVGRGGI 239
Query: 237 VDTNALVKALEEGWIAGAGLDVYEEEPLPKDHPL--TKFDN-VVLTPHI 282
V+ L + LE + A DV+ +EP KDH K N ++LTPHI
Sbjct: 240 VNEKDLAEILETKDLYYAS-DVFVKEPFEKDHAFLNPKIQNKLLLTPHI 287
>pir||F83066 glycerate dehydrogenase PA4626 [imported] - Pseudomonas aeruginosa
(strain PAO1) >gi|9950879|gb|AAG08014.1|AE004877_1
(AE004877) glycerate dehydrogenase [Pseudomonas
aeruginosa]
Length = 323
Score = 149 bits (373), Expect = 3e-35
Identities = 92/260 (35%), Positives = 140/260 (53%), Gaps = 13/260 (5%)
Query: 48 IIVRSKPKVTRKVIESAPKLKVIARAGVGLDNIDVEAAKERGIEVVNAPAASSRSVAELA 107
+ + +K + + I + P+L++I + G +NID+ AA+ERGI V N + SVA+
Sbjct: 52 VAISNKVPIDAQCIAACPELELILISATGTNNIDLAAARERGIVVANCHGYGTPSVAQHT 111
Query: 108 VALMFAVARKIAFADRKMREGVWAKKQAMG------IELEGKTLGIIGFGRIGYQVAKIA 161
+AL+ A+A ++ + +R G W + +ELEGKTLG++G G +G VA++A
Sbjct: 112 LALLLALATRLPDYQQAVRSGRWQQSSQFCLLDFPIVELEGKTLGLLGHGELGGAVARLA 171
Query: 162 RALGMNLLLYDPYPNEERAKEVGGKFVDLETLLRESDIVTIHVPLLESTYHLINEERLKL 221
A GM +LL RA + L LL D +T+H PL E T ++ L L
Sbjct: 172 EAFGMRVLLGQLPGRPARADRL-----PLGELLPRVDALTLHCPLTEDTRGMLGSAELAL 226
Query: 222 MKKSAILINTSRGAVVDTNALVKALEEGWIAGAGLDVYEEEPLPKDHPLTKFD--NVVLT 279
MK A L+NT+RG +VD AL AL G + GA DV EP +PL D +++T
Sbjct: 227 MKPGAFLVNTARGGLVDEQALADALRGGHLGGAATDVLSVEPPRNGNPLLAPDIPRLIVT 286
Query: 280 PHIGASTVEAQERAGVEVAE 299
PH + EA++R ++AE
Sbjct: 287 PHNAWGSREARQRIVGQLAE 306
>pir||T00876 hypothetical protein F17K2.16 - Arabidopsis thaliana
>gi|2979553|gb|AAC06162.1| (AC003680) putative glycerate
dehydrogenase [Arabidopsis thaliana]
Length = 327
Score = 148 bits (371), Expect = 6e-35
Identities = 90/260 (34%), Positives = 141/260 (53%), Gaps = 7/260 (2%)
Query: 45 VEAIIVRSKPKVTRKVIESAPKLKVIARAGVGLDNIDVEAAKERGIEVVNAPAASSRSVA 104
+ AII VT +I P L+++ G+D++D+ + RGI V NA ++ S VA
Sbjct: 58 ISAIIAPVAAPVTADLIRILPNLRLVVTTSAGVDHVDLVECRRRGISVANAGSSFSEDVA 117
Query: 105 ELAVALMFAVARKIAFADRKMREGVWAKK--QAMGIELEGKTLGIIGFGRIGYQVAKIAR 162
+ AV L+ V R+I+ A+R +++ W K +G +L K +GI+G G IG +VA
Sbjct: 118 DTAVGLLIDVFRRISAANRFVKQRFWPLKGDYPLGSKLGRKRIGIVGLGSIGSKVATRLD 177
Query: 163 ALGMNLLLYDPYPNEERAKEVGGKFVDLETLLRESDIVTIHVPLLESTYHLINEERLKLM 222
A G + N + ++D+E + SD + I L E T LIN++ L +
Sbjct: 178 AFGCQISYSSR--NRKPYDVPYHYYMDIEEMAANSDALIICCELNEKTLRLINKDVLSAL 235
Query: 223 KKSAILINTSRGAVVDTNALVKALEEGWIAGAGLDVYEEEP-LPKDHPLTKFDNVVLTPH 281
K +++N +RGA++D +V+ L EG I GAGLDV+E+EP +PK+ L + DNVV +PH
Sbjct: 236 GKRGVIVNVARGAIIDEEEMVRCLREGEIGGAGLDVFEDEPNVPKE--LFELDNVVFSPH 293
Query: 282 IGASTVEAQERAGVEVAEKV 301
T+E E G V +
Sbjct: 294 SAFMTLEGLEELGKVVVGNI 313
>pir||D71373 probable D-specific D-2-hydroxyacid dehydrogenase - syphilis
spirochete >gi|3322294|gb|AAC65033.1| (AE001189)
D-specific D-2-hydroxyacid dehydrogenase [Treponema
pallidum]
Length = 331
Score = 147 bits (368), Expect = 1e-34
Identities = 103/316 (32%), Positives = 167/316 (52%), Gaps = 24/316 (7%)
Query: 10 APLHEKAIQILKDAGLEVIYEEYPEEDRLVELVKDVEAIIVRSKPKVTRKVIE--SAPKL 67
AP EK Q G+ V E P + EL+K E ++V + +V + A KL
Sbjct: 13 APYVEKWKQ--SHPGVVVDTYEEPLTAKNKELLKGYEGLVVMQFLAMEDEVYDYMGACKL 70
Query: 68 KVIARAGVGLDNIDVEAAKERGIEVVNAPAASSRSVAELAVALMFAV---ARKIAFADRK 124
KV++ G D + K+ GI + N P+ S ++ E A+A + AR+I RK
Sbjct: 71 KVLSTRTAGFDMYNATLLKKHGIRLTNVPSYSPNAIGEYALAAALQLTRHAREIETFVRK 130
Query: 125 MREGVWAKKQAMGIELEGKTLGIIGFGRIGYQVAKIARALGMNLLLYDPYPNEERAKEVG 184
R+ W +K + EL +GI+G GRIG A++ + +G ++ +DPYPN+ + +
Sbjct: 131 -RDFRW-QKPILSKELRCSRVGILGTGRIGQAAARLFKGVGAQVVGFDPYPNDAAKEWL- 187
Query: 185 GKFVDLETLLRESDIVTIHVPLLESTYHLINEERLKLMKKSAILINTSRGAVVDTNALVK 244
+V ++ LL SD++++H+P + ++HLIN + + MK L+NT+RGAV+D+ AL+
Sbjct: 188 -TYVSMDELLSTSDVISLHMPATKDSHHLINAKTIAQMKDGVYLVNTARGAVIDSQALLD 246
Query: 245 ALEEGWIAGAGLDVYEEEP--LPKD---HPLT--------KFDNVVLTPHIGASTVEAQE 291
+L++G IAGA LD YE E +PKD +P+T + ++ TPHI T A E
Sbjct: 247 SLDKGKIAGAALDAYEFEGPYIPKDNGNNPITDTVYARLVAHERIIYTPHIAFYTETAIE 306
Query: 292 RAGVEVAEKVVKILKG 307
+ +L+G
Sbjct: 307 NMVFNSLDACTTVLRG 322
>pir||G71974 probable keto-acid dehydrogenase - Helicobacter pylori (strain
J99) >gi|4154596|gb|AAD05669.1| (AE001448) putative
keto-acid dehydrogenase [Helicobacter pylori J99]
Length = 314
Score = 147 bits (367), Expect = 2e-34
Identities = 102/289 (35%), Positives = 162/289 (55%), Gaps = 22/289 (7%)
Query: 6 VLVAAPLHEKAIQILKDAGLEVIYEEYPEEDRLVELVKDVEA-IIVRSKPKVTRKVIESA 64
+L A + KA+++LK+ + + E +++VE + +EA I+V +K +T++V+
Sbjct: 9 ILDAKSVGLKALEVLKEVA-DFDFYEVTSPNQIVE--RSIEAEIMVLNKVVITQEVLSQL 65
Query: 65 PKLKVIARAGVGLDNIDVEAAKERGIEVVNAPAASSRSVAELAVALMFAVARKIAFADRK 124
PKLK+I G DN+D+++AK GIEV N A S+ SVA+ +A ++ +I DR
Sbjct: 66 PKLKLICITATGTDNVDIKSAKALGIEVKNVSAYSTESVAQHTLACALSLLGRINDYDRY 125
Query: 125 MREGVWAKKQ--------AMGIELEGKTLGIIGFGRIGYQVAKIARALGMNLLLYDPYPN 176
+ G +++ MG+ ++G G+IG G IG +VAK+A+A G ++ + P
Sbjct: 126 CKSGEYSQSDIFTHISDIKMGL-IKGGQWGVIGLGNIGKRVAKLAQAFGAKVVYFSPKDK 184
Query: 177 EERAKEVGGKFVDLETLLRESDIVTIHVPLLESTYHLINEERLKLMKKSAILINTSRGAV 236
+E + + LE LL+ S I++IH PL EST LI + L+ +K AILIN RG +
Sbjct: 185 KEEYER-----LSLEELLKTSGIISIHAPLNESTRDLIALKELQSLKDGAILINVGRGGI 239
Query: 237 VDTNALVKALEEGWIAGAGLDVYEEEPLPKDHPL--TKFDN-VVLTPHI 282
V+ L LE + A DV+ +EP KDH K N ++LTPHI
Sbjct: 240 VNEKDLALILETKDLYYAS-DVFVKEPFEKDHAFLNPKIQNKLLLTPHI 287
>emb|CAA73696.1| (Y13245) NAD-dependent formate dehydrogenase [Moraxella sp.]
Length = 402
Score = 146 bits (365), Expect = 3e-34
Identities = 94/270 (34%), Positives = 144/270 (52%), Gaps = 18/270 (6%)
Query: 35 EDRLVELVKDVEAIIVRSKP----KVTRKVIESAPKLKVIARAGVGLDNIDVEAAKERGI 90
+ L + + D E II S+P +T + I APKLK+ AG+G D++D++AA + I
Sbjct: 81 DSELEKHLHDAEVII--SQPFWPAYLTAERIAKAPKLKLALTAGIGSDHVDLQAAIDNNI 138
Query: 91 EVVNAPAASSRSVAELAVALMFAVARKIAFADRKMREGVW--AKKQAMGIELEGKTLGII 148
V +S SVAE V ++ + R + R G W A A ++EG +G +
Sbjct: 139 TVAEVTYCNSNSVAEHVVMMVLGLVRNYIPSHDWARNGGWNIADCVARSYDVEGMHVGTV 198
Query: 149 GFGRIGYQVAKIARALGMNLLLYDPYPNEERAKEVGGKFVDL------ETLLRESDIVTI 202
GRIG +V ++ M+L Y + R E K ++L E + D+VT+
Sbjct: 199 AAGRIGLRVLRLLAPFDMHL----HYTDRHRLPEAVEKELNLTWHATREDMYGACDVVTL 254
Query: 203 HVPLLESTYHLINEERLKLMKKSAILINTSRGAVVDTNALVKALEEGWIAGAGLDVYEEE 262
+ PL T H+IN+E LKL K+ A L+NT+RG + D +A+V+ALE G +AG DV+ +
Sbjct: 255 NCPLHPETEHMINDETLKLFKRGAYLVNTARGKLCDRDAIVRALESGRLAGYAGDVWFPQ 314
Query: 263 PLPKDHPLTKFDNVVLTPHIGASTVEAQER 292
P P DHP + +TPHI +++ AQ R
Sbjct: 315 PAPNDHPWRTMPHNGMTPHISGTSLSAQTR 344
>gb|AAG10470.1|AF279106_32 (AF279106) predicted NAD-dependent formate dehydrogenase
[uncultured proteobacterium EBAC31A08]
Length = 398
Score = 146 bits (364), Expect = 4e-34
Identities = 91/290 (31%), Positives = 157/290 (53%), Gaps = 8/290 (2%)
Query: 18 QILKDAGLEVIYEEYPEEDRLVELVKDVEAIIVRSKP----KVTRKVIESAPKLKVIARA 73
+ L+DAG ++ + D + V+A IV S+P +TR +++AP LK+ A
Sbjct: 61 KFLEDAGHTLVVTSDKDGDGCEADKELVDADIVISQPFFPYYLTRDKMKTAPNLKMAITA 120
Query: 74 GVGLDNIDVEAAKERGIEVVNAPAASSRSVAELAVALMFAVARKIAFADRKMREGVWAKK 133
G+G D++D++AA + ++VV +SRSVAE V ++ ++ R R ++EG W
Sbjct: 121 GIGSDHVDLQAAMDNSVDVVEVTYCNSRSVAEHIVMMILSMVRDYHTQHRIVKEGGWNIA 180
Query: 134 QAM--GIELEGKTLGIIGFGRIGYQVAKIARALGMNLLLYDPYP-NEERAKEVGGKFVD- 189
A+ ++EG +G + GRIG + + + ++L +D + ++E E+ + D
Sbjct: 181 DAVQRSYDVEGMHVGTVAAGRIGIDMLRKMKPFDVHLHYFDIHKLSDEIEAELNLTYHDS 240
Query: 190 LETLLRESDIVTIHVPLLESTYHLINEERLKLMKKSAILINTSRGAVVDTNALVKALEEG 249
+E+L+ D+V I PL T HL ++E + MK+ A +INT+RG + D +A+ + LE G
Sbjct: 241 VESLVAVCDVVNISCPLHPKTEHLFDDEMISKMKRGAYIINTARGKICDKDAIARGLESG 300
Query: 250 WIAGAGLDVYEEEPLPKDHPLTKFDNVVLTPHIGASTVEAQERAGVEVAE 299
++G DV+ +P P DH N +TPH +++ AQ R V E
Sbjct: 301 QLSGYAGDVWFPQPAPNDHVWRTMPNHGMTPHTSGTSLSAQTRYAAGVRE 350
>sp|P26298|LDHD_LACPE D-LACTATE DEHYDROGENASE (D-LDH) >gi|98677|pir||A40885 D-lactate
dehydrogenase (EC 1.1.1.28) - Lactobacillus pentosus
(ATCC 8041) >gi|216746|dbj|BAA14352.1| (D90339)
D-lactate dehydrogenase [Lactobacillus plantarum]
Length = 332
Score = 145 bits (363), Expect = 5e-34
Identities = 93/284 (32%), Positives = 149/284 (51%), Gaps = 20/284 (7%)
Query: 22 DAGLEVIYEEYPEEDRLVELVKDVEAIIVRSKPKVTRKVIESAPK--LKVIARAGVGLDN 79
D ++++ E E++ V+L K + V + T +V+ +K I+ VG+DN
Sbjct: 25 DVEVKLVPELLTEDN--VDLAKGFDGADVYQQKDYTAEVLNKLADEGVKNISLRNVGVDN 82
Query: 80 IDVEAAKERGIEVVNAPAASSRSVAELAVALMFAVARKIAFADRKMREGVWAKKQAMGIE 139
+DV K RG+ + N PA S ++AEL+V + + R+ ++K+ + + + E
Sbjct: 83 LDVPTVKARGLNISNVPAYSPNAIAELSVTQLMQLLRQTPMFNKKLAKQDFRWAPDIAKE 142
Query: 140 LEGKTLGIIGFGRIGYQVAKIARALGMNLLLYDPYPNEERAKEVGGKFVD-LETLLRESD 198
L T+G+IG GRIG I + G ++ YD Y N E KE G +VD L+ L ++D
Sbjct: 143 LNTMTVGVIGTGRIGRAAIDIFKGFGAKVIGYDVYRNAELEKE--GMYVDTLDELYAQAD 200
Query: 199 IVTIHVPLLESTYHLINEERLKLMKKSAILINTSRGAVVDTNALVKALEEGWIAGAGLDV 258
++T+HVP L+ YH++N + MK A ++N +RG ++D+ L+KAL+ G +AGA L
Sbjct: 201 VITLHVPALKDNYHMLNADAFSKMKDGAYILNFARGTLIDSEDLIKALDSGKVAGAALVT 260
Query: 259 YEEEP--LPKD-----------HPLTKFDNVVLTPHIGASTVEA 289
YE E KD L DNV++TPH T A
Sbjct: 261 YEYETKIFNKDLEGQTIDDKVFMNLFNRDNVLITPHTAFYTETA 304
>gb|AAG34690.1|AF310956_5 (AF310956) D-2-hydroxyacid dehydrogenase VanHB2 [Enterococcus
faecium]
Length = 323
Score = 144 bits (360), Expect = 1e-33
Identities = 100/273 (36%), Positives = 142/273 (51%), Gaps = 26/273 (9%)
Query: 46 EAIIVRSKPKVTRKVIESAPKL--KVIARAGVGLDNIDVEAAKERGIEVVNAPAASSRSV 103
+ + V K +V+ I + K+ K I+ +G D+ID AA+ GI V A S SV
Sbjct: 50 QCVSVGHKSEVSEATILALRKVGVKYISTRSIGCDHIDTTAAERMGISV-GTVAYSPDSV 108
Query: 104 AELAVALMFAVARKIAFADRKMREGVWAKKQAMGIELEGKTLGIIGFGRIGYQVAKIARA 163
A+ A+ LM R + + + + G EL T+G+IG G IG V K R
Sbjct: 109 ADYALMLMLMAIRGAKPTMHAVAQQDFRLDRIRGKELGDMTVGVIGTGHIGQAVVKRLRG 168
Query: 164 LGMNLLLYDPYPNEERAKEVGGKFVDLETLLRESDIVTIHVPLLESTYHLINEERLKLMK 223
G ++L YD ++++ +V L+ LL+ SDIVT+HVPL T HLI ++++ MK
Sbjct: 169 FGCHVLAYD------NSRKMDADYVQLDELLKNSDIVTLHVPLCADTRHLIGQKQIGEMK 222
Query: 224 KSAILINTSRGAVVDTNALVKALEEGWIAGAGLDVYEEE---------PLPKDHP----L 270
+ A LINT RGA+VDT ALV+ALE G + GA LDV E E DHP L
Sbjct: 223 QGAFLINTGRGALVDTGALVEALESGKLGGAALDVLEGEDQFVYTDCSQKVLDHPFLSQL 282
Query: 271 TKFDNVVLTPHIGASTVEAQERAGVEVAEKVVK 303
+ NV++TPH T ER + EK ++
Sbjct: 283 LRMPNVIITPH----TAYYTERVLQDTTEKTIR 311
>pir||DELBC D-2-hydroxyisocaproate dehydrogenase (EC 1.1.1.-) - Lactobacillus
casei >gi|149538|gb|AAA25236.1| (M26929)
D-2-hydroxyisocaproate dehydrogenase [Lactobacillus
casei]
Length = 335
Score = 144 bits (359), Expect = 1e-33
Identities = 95/288 (32%), Positives = 142/288 (48%), Gaps = 18/288 (6%)
Query: 18 QILKDAGLEVIYEEYPEEDRLVELVKDVEAIIVRSKPKVTRKVIES--APKLKVIARAGV 75
Q KD G + Y ++ VE K + I V E A +K + V
Sbjct: 18 QWAKDTGNTLEYHTEFLDENTVEWAKGFDGINSLQTTPYAAGVFEKMHAYGIKFLTIRNV 77
Query: 76 GLDNIDVEAAKERGIEVVNAPAASSRSVAELAVALMFAVARKIAFADRKMREGVWAKKQA 135
G DNID+ A K+ GI + N PA S ++AE A+ + R + +++ G + K
Sbjct: 78 GTDNIDMTAMKQYGIRLSNVPAYSPAAIAEFALTDTLYLLRNMGKVQAQLQAGDYEKAGT 137
Query: 136 -MGIELEGKTLGIIGFGRIGYQVAKIARALGMNLLLYDPYPNEERAKEVGGKFVDLETLL 194
+G EL +T+G++G G IG K+ + G ++ YDPYP + + +V LE L
Sbjct: 138 FIGKELGQQTVGVMGTGHIGQVAIKLFKGFGAKVIAYDPYPMKGDHPDFD--YVSLEDLF 195
Query: 195 RESDIVTIHVPLLESTYHLINEERLKLMKKSAILINTSRGAVVDTNALVKALEEGWIAGA 254
++SD++ +HVP +E H+INE LMK AI+INT+R ++DT A++ L+ G +AG
Sbjct: 196 KQSDVIDLHVPGIEQNTHIINEAAFNLMKPGAIVINTARPNLIDTQAMLSNLKSGKLAGV 255
Query: 255 GLDVYEEEPL-------------PKDHPLTKFDNVVLTPHIGASTVEA 289
G+D YE E P L NVVL+PHI T A
Sbjct: 256 GIDTYEYETEDLLNLAKHGSFKDPLWDELLGMPNVVLSPHIAYYTETA 303
>sp|P17584|DHD2_LACCA D-2-HYDROXYISOCAPROATE DEHYDROGENASE (D-HICDH)
>gi|2392297|pdb|1DXY| Structure Of
D-2-Hydroxyisocaproate Dehydrogenase
Length = 333
Score = 144 bits (359), Expect = 1e-33
Identities = 95/288 (32%), Positives = 142/288 (48%), Gaps = 18/288 (6%)
Query: 18 QILKDAGLEVIYEEYPEEDRLVELVKDVEAIIVRSKPKVTRKVIES--APKLKVIARAGV 75
Q KD G + Y ++ VE K + I V E A +K + V
Sbjct: 18 QWAKDTGNTLEYHTEFLDENTVEWAKGFDGINSLQTTPYAAGVFEKMHAYGIKFLTIRNV 77
Query: 76 GLDNIDVEAAKERGIEVVNAPAASSRSVAELAVALMFAVARKIAFADRKMREGVWAKKQA 135
G DNID+ A K+ GI + N PA S ++AE A+ + R + +++ G + K
Sbjct: 78 GTDNIDMTAMKQYGIRLSNVPAYSPAAIAEFALTDTLYLLRNMGKVQAQLQAGDYEKAGT 137
Query: 136 -MGIELEGKTLGIIGFGRIGYQVAKIARALGMNLLLYDPYPNEERAKEVGGKFVDLETLL 194
+G EL +T+G++G G IG K+ + G ++ YDPYP + + +V LE L
Sbjct: 138 FIGKELGQQTVGVMGTGHIGQVAIKLFKGFGAKVIAYDPYPMKGDHPDFD--YVSLEDLF 195
Query: 195 RESDIVTIHVPLLESTYHLINEERLKLMKKSAILINTSRGAVVDTNALVKALEEGWIAGA 254
++SD++ +HVP +E H+INE LMK AI+INT+R ++DT A++ L+ G +AG
Sbjct: 196 KQSDVIDLHVPGIEQNTHIINEAAFNLMKPGAIVINTARPNLIDTQAMLSNLKSGKLAGV 255
Query: 255 GLDVYEEEPL-------------PKDHPLTKFDNVVLTPHIGASTVEA 289
G+D YE E P L NVVL+PHI T A
Sbjct: 256 GIDTYEYETEDLLNLAKHGSFKDPLWDELLGMPNVVLSPHIAYYTETA 303
>sp|Q07103|FDH_NEUCR FORMATE DEHYDROGENASE (NAD-DEPENDENT FORMATE DEHYDROGENASE) (FDH)
>gi|539386|pir||A47117 formate dehydrogenase (EC
1.2.1.2) - Neurospora crassa >gi|1321604|gb|AAA99900.1|
(L13964) formate dehydrogenase [Neurospora crassa]
>gi|11595632|emb|CAC18252.1| (AL451018) formate
dehydrogenase [Neurospora crassa]
Length = 375
Score = 143 bits (358), Expect = 2e-33
Identities = 91/264 (34%), Positives = 143/264 (53%), Gaps = 12/264 (4%)
Query: 56 VTRKVIESAPKLKVIARAGVGLDNIDVEAAKER--GIEVVNAPAASSRSVAELAVALMFA 113
+T + + A KLK+ AG+G D++D+ AA + GI V ++ SVAE + +
Sbjct: 75 LTAERLARAKKLKLAVTAGIGSDHVDLNAANKTNGGITVAEVTGSNVVSVAEHVLMTILV 134
Query: 114 VARKIAFADRKMREGVWAKKQAMGIE--LEGKTLGIIGFGRIGYQVAKIARALGMNLLLY 171
+ R A +++EG W +A E LEGK +G +G GRIG +V + + LLY
Sbjct: 135 LVRNFVPAHEQIQEGRWDVAEAAKNEFDLEGKVVGTVGVGRIGERVLRRLKPFDCKELLY 194
Query: 172 DPYP--NEERAKEVGGKFV-DLETLLRESDIVTIHVPLLESTYHLINEERLKLMKKSAIL 228
Y + E+ E+G + V DLE +L + D+VTI+ PL E T L N+E + MKK + L
Sbjct: 195 YDYQPLSAEKEAEIGCRRVADLEEMLAQCDVVTINCPLHEKTQGLFNKELISKMKKGSWL 254
Query: 229 INTSRGAVVDTNALVKALEEGWIAGAGLDVYEEEPLPKDHPLTKFDNV-----VLTPHIG 283
+NT+RGA+V + +AL+ G + G G DV+ +P P+DHPL N + PH+
Sbjct: 255 VNTARGAIVVKEDVAEALKSGHLRGYGGDVWFPQPAPQDHPLRYAKNPFGGGNAMVPHMS 314
Query: 284 ASTVEAQERAGVEVAEKVVKILKG 307
++++AQ+R + L G
Sbjct: 315 GTSLDAQKRYAAGTKAIIESYLSG 338
>gb|AAG37025.1|AF277571_2 (AF277571) alpha keto acid dehydrogenase [Enterococcus faecium]
Length = 323
Score = 143 bits (358), Expect = 2e-33
Identities = 97/284 (34%), Positives = 148/284 (51%), Gaps = 22/284 (7%)
Query: 18 QILKDAGLEVIYEEYPEEDRLVELVKDVEAIIVRSKPKVTRKVIESAPK--LKVIARAGV 75
++ + G+ V E + +L + + V K +++ +++ + +K I+ +
Sbjct: 22 KLSSEYGVTVSLIEDVVSEHNAKLADGCQCVSVSHKAELSEQLLLALKHAGVKYISTRSI 81
Query: 76 GLDNIDVEAAKERGIEVVNAPAASSRSVAELAVALMFAVARKIAFADRKMREGVWAKKQA 135
G ++ID++AA + G+ V A S SVA+ V LM + R R ++ +
Sbjct: 82 GFNHIDIQAAGQLGM-AVGTVAYSPGSVADYTVMLMLMLLRGTKSVLRGTQKQNYCLNDC 140
Query: 136 MGIELEGKTLGIIGFGRIGYQVAKIARALGMNLLLYDPYPNEERAKEVGGKFVDLETLLR 195
G EL+ T+G++G GRIG V + +G +L YD R + G +V LL+
Sbjct: 141 RGKELQDLTVGVLGTGRIGQAVMERLEGIGCKVLAYD------RTHKAGANYVSFCELLK 194
Query: 196 ESDIVTIHVPLLESTYHLINEERLKLMKKSAILINTSRGAVVDTNALVKALEEGWIAGAG 255
SDIVT+HVPL E T H+I E+L++MK+ A+LINT+RGA+VDT ALV AL+E I GA
Sbjct: 195 SSDIVTLHVPLAEDTRHMIGREQLEMMKREALLINTARGALVDTAALVAALKEQKIGGAA 254
Query: 256 LDVYEEE---------PLPKDHP----LTKFDNVVLTPHIGAST 286
LDV E E HP L K NV++TPH T
Sbjct: 255 LDVLEGEEGIFYHECTQKTIGHPYLSVLQKMPNVIVTPHTAYHT 298
>gb|AAC49766.1| (AF004096) NAD-dependent formate dehydrogenase [Candida boidinii]
>gi|5824352|emb|CAB54834.1| (AJ245934) formate
dehydrogenase [Candida boidinii]
Length = 364
Score = 142 bits (354), Expect = 5e-33
Identities = 99/289 (34%), Positives = 147/289 (50%), Gaps = 16/289 (5%)
Query: 20 LKDAGLEVIY--EEYPEEDRLVELVKDVEAIIVRS--KPKVTRKVIESAPKLKVIARAGV 75
LKD G E+I ++ E L + + D + II +T++ ++ A LK++ AGV
Sbjct: 34 LKDQGHELITTSDKEGETSELDKHIPDADIIITTPFHPAYITKERLDKAKNLKLVVVAGV 93
Query: 76 GLDNIDVEAAKERG--IEVVNAPAASSRSVAELAVALMFAVARKIAFADRKMREGVW--A 131
G D+ID++ + G I V+ ++ SVAE V M + R A ++ W A
Sbjct: 94 GSDHIDLDYINQTGKKISVLEVTGSNVVSVAEHVVMTMLVLVRNFVPAHEQIINHDWEVA 153
Query: 132 KKQAMGIELEGKTLGIIGFGRIGYQVAKIARALGMNLLLYDPY---PNEERAKEVGGKFV 188
++EGKT+ IG GRIGY+V + LLY Y P E K +
Sbjct: 154 AIAKDAYDIEGKTIATIGAGRIGYRVLERLLPFNPKELLYYDYQALPKEAEEKVGARRVE 213
Query: 189 DLETLLRESDIVTIHVPLLESTYHLINEERLKLMKKSAILINTSRGAVVDTNALVKALEE 248
++E L+ ++DIVT++ PL T LIN+E L KK A L+NT+RGA+ + ALE
Sbjct: 214 NIEELVAQADIVTVNAPLHAGTKGLINKELLSKFKKGAWLVNTARGAICVAEDVAAALES 273
Query: 249 GWIAGAGLDVYEEEPLPKDHPLTKFDNV-----VLTPHIGASTVEAQER 292
G + G G DV+ +P PKDHP N +TPH +T++AQ R
Sbjct: 274 GQLRGYGGDVWFPQPAPKDHPWRDMRNKYGAGNAMTPHYSGTTLDAQTR 322
>emb|CAA09466.2| (AJ011046) formate dehydrogenase [Candida boidinii]
Length = 364
Score = 141 bits (353), Expect = 7e-33
Identities = 100/289 (34%), Positives = 146/289 (49%), Gaps = 16/289 (5%)
Query: 20 LKDAGLEVIYEEYPEEDRLV--ELVKDVEAIIVRS--KPKVTRKVIESAPKLKVIARAGV 75
LKD G E+I E V + + D + II +T++ I+ A KLK++ AGV
Sbjct: 34 LKDQGHELITTSDKEGGNSVLDQHIPDADIIITTPFHPAYITKERIDKAKKLKLVVVAGV 93
Query: 76 GLDNIDVEAAKERG--IEVVNAPAASSRSVAELAVALMFAVARKIAFADRKMREGVW--A 131
G D+ID++ + G I V+ ++ SVAE V M + R A ++ W A
Sbjct: 94 GSDHIDLDYINQTGKKISVLEVTGSNVVSVAEHVVMTMLVLVRNFVPAHEQIINHDWEVA 153
Query: 132 KKQAMGIELEGKTLGIIGFGRIGYQVAKIARALGMNLLLYDPY---PNEERAKEVGGKFV 188
++EGKT+ IG GRIGY+V + LLY Y P + K +
Sbjct: 154 AIAKDAYDIEGKTIATIGAGRIGYRVLERLVPFNPKELLYYDYQALPKDAEEKVGARRVE 213
Query: 189 DLETLLRESDIVTIHVPLLESTYHLINEERLKLMKKSAILINTSRGAVVDTNALVKALEE 248
++E L+ ++DIVT++ PL T LIN+E L KK A L+NT+RGA+ + ALE
Sbjct: 214 NIEELVAQADIVTVNAPLHAGTKGLINKELLSKFKKGAWLVNTARGAICVAEDVAAALES 273
Query: 249 GWIAGAGLDVYEEEPLPKDHPLTKFDNV-----VLTPHIGASTVEAQER 292
G + G G DV+ +P PKDHP N +TPH +T++AQ R
Sbjct: 274 GQLRGYGGDVWFPQPAPKDHPWRDMRNKYGAGNAMTPHYSGTTLDAQTR 322
>gb|AAF36802.1|AF155139_1 (AF155139) putative lactate dehydrogenase VanHE [Paenibacillus
popilliae]
Length = 322
Score = 141 bits (352), Expect = 9e-33
Identities = 98/272 (36%), Positives = 145/272 (53%), Gaps = 26/272 (9%)
Query: 46 EAIIVRSKPKVTRKVIESAPK--LKVIARAGVGLDNIDVEAAKERGIEVVNAPAASSRSV 103
+ I V K +++ ++ + + +K I+ +G ++IDV+AA+ GI V N A S SV
Sbjct: 49 QCISVGHKSEISESILLALKESGVKYISTRSIGCNHIDVKAAESMGIAVGNV-AYSPDSV 107
Query: 104 AELAVALMFAVARKIAFADRKMREGVWAKKQAMGIELEGKTLGIIGFGRIGYQVAKIARA 163
A+ + LM R + + + G EL T+G++G G+IG V + R
Sbjct: 108 ADYTLMLMLMAIRNAKSIVSRAEKYDFRLDTVPGKELREMTVGVLGTGQIGKAVIERLRG 167
Query: 164 LGMNLLLYDPYPNEERAKEVGGKFVDLETLLRESDIVTIHVPLLESTYHLINEERLKLMK 223
G ++L Y +KE +V L LL++SDI+TIHVPL TYH+I E+++ +K
Sbjct: 168 FGCHVLAYG------HSKEAAANYVSLNELLQKSDILTIHVPLGTDTYHMIGHEQIEAVK 221
Query: 224 KSAILINTSRGAVVDTNALVKALEEGWIAGAGLDVYE-EEPL--------PKDHPLT--- 271
+ A LINT+RG +VDT AL+KALE G + GA LDV E EE L P D+ L
Sbjct: 222 QGAFLINTARGGLVDTGALIKALENGRLGGAALDVLEGEEGLFYFDCTQKPIDNQLLLKL 281
Query: 272 -KFDNVVLTPHIGASTVEAQERAGVEVAEKVV 302
K NV++TPH T RA + EK +
Sbjct: 282 HKMPNVIITPH----TAYYTGRALYDTVEKTI 309
>pir||JC4252 formate dehydrogenase (EC 1.2.1.2) - yeast (Candida methylica)
>gi|1181204|emb|CAA57036.1| (X81129) NAD-dependent
formate dehydrogenase [Candida methylica]
Length = 364
Score = 141 bits (351), Expect = 1e-32
Identities = 99/289 (34%), Positives = 146/289 (50%), Gaps = 16/289 (5%)
Query: 20 LKDAGLEVIY--EEYPEEDRLVELVKDVEAIIVRS--KPKVTRKVIESAPKLKVIARAGV 75
LKD G E+I ++ E L + + D + II +T++ ++ A LK + AGV
Sbjct: 34 LKDQGHELITTSDKEGETSELDKHIPDADIIITTPFHPAYITKERLDKAKNLKSVVVAGV 93
Query: 76 GLDNIDVEAAKERG--IEVVNAPAASSRSVAELAVALMFAVARKIAFADRKMREGVW--A 131
G D+ID++ + G I V+ ++ SVAE V M + R A ++ W A
Sbjct: 94 GSDHIDLDYINQTGKKISVLEVTGSNVVSVAEHVVMTMLVLVRNFVPAHEQIINHDWEVA 153
Query: 132 KKQAMGIELEGKTLGIIGFGRIGYQVAKIARALGMNLLLYDPY---PNEERAKEVGGKFV 188
++EGKT+ IG GRIGY+V + LLY Y P E K +
Sbjct: 154 AIAKDAYDIEGKTIATIGAGRIGYRVLERLLPFNPKELLYYDYQALPKEAEEKVGARRVE 213
Query: 189 DLETLLRESDIVTIHVPLLESTYHLINEERLKLMKKSAILINTSRGAVVDTNALVKALEE 248
++E L+ ++DIVT++ PL T LIN+E L KK A L+NT+RGA+ + ALE
Sbjct: 214 NIEELVAQADIVTVNAPLHAGTKGLINKELLSKFKKGAWLVNTARGAICVAEDVAAALES 273
Query: 249 GWIAGAGLDVYEEEPLPKDHPLTKFDNV-----VLTPHIGASTVEAQER 292
G + G G DV+ +P PKDHP N +TPH +T++AQ R
Sbjct: 274 GQLRGYGGDVWFPQPAPKDHPWRDMRNKYGAGNAMTPHYSGTTLDAQTR 322
>emb|CAA42781.1| (X60220) D-lactate dehydrogenase [Lactobacillus delbrueckii]
>gi|228094|prf||1717214A lactate dehydrogenase
[Lactobacillus delbrueckii]
Length = 333
Score = 140 bits (350), Expect = 2e-32
Identities = 86/299 (28%), Positives = 153/299 (50%), Gaps = 18/299 (6%)
Query: 25 LEVIYEEYPEEDRLVELVKDVEAIIVRSKPKVTRKVIESAPK--LKVIARAGVGLDNIDV 82
+EV Y + V L K + ++V + T + +++ + ++ VG+DNID+
Sbjct: 27 VEVEYTDKLLTPETVALAKGADGVVVYQQLDYTAETLQALADNGITKMSLRNVGVDNIDM 86
Query: 83 EAAKERGIEVVNAPAASSRSVAELAVALMFAVARKIAFADRKMREGVWAKKQAMGIELEG 142
AKE G ++ N P S ++AE A A+ R+ D K+ +G E+
Sbjct: 87 AKAKELGFQITNVPVYSPNAIAEHAAIQAAAILRQDKAMDEKVARHDLRWAPTIGREVRD 146
Query: 143 KTLGIIGFGRIGYQVAKIARALGMNLLLYDPYPNEERAKEVGGKFVD-LETLLRESDIVT 201
+ +G+IG G IG +I G ++ YD + N E K+ G +VD L+ L +++D+++
Sbjct: 147 QVVGVIGTGHIGQVFMQIMEGFGAKVITYDIFRNPELEKK--GYYVDSLDDLYKQADVIS 204
Query: 202 IHVPLLESTYHLINEERLKLMKKSAILINTSRGAVVDTNALVKALEEGWIAGAGLDVYEE 261
+HVP + + H+IN+E + MK+ +++N SRG +VDT+A+++ L+ G I G +DVYE
Sbjct: 205 LHVPDVPANVHMINDESIAKMKQDVVIVNVSRGPLVDTDAVIRGLDSGKIFGYAMDVYEG 264
Query: 262 E-------------PLPKDHPLTKFDNVVLTPHIGASTVEAQERAGVEVAEKVVKILKG 307
E P + L NV++TPH T A V+ + +++++G
Sbjct: 265 EVGIFNEDWEGKEFPDARLADLIARPNVLVTPHTAFYTTHAVRNMVVKAFDNNLELVEG 323
>gb|AAC99363.1| (AF071558) D-lactate dehydrogenase [Lactobacillus johnsonii]
Length = 337
Score = 140 bits (349), Expect = 2e-32
Identities = 93/307 (30%), Positives = 156/307 (50%), Gaps = 24/307 (7%)
Query: 21 KDA--GLEVIYEEYPEEDRLVELVKDVEAIIVRSKPKVTRKVIESAPKLKV--IARAGVG 76
KDA +EV Y + +L K + ++V + T + +++ V ++ VG
Sbjct: 21 KDAHKDIEVEYTDKLLAPETAKLAKGADGVVVYQQLDYTPETLQALADAGVTKMSLRNVG 80
Query: 77 LDNIDVEAAKERGIEVVNAPAASSRSVAELAVALMFAVARKIAFADRKM--REGVWAKKQ 134
+DNID++ AKE G E+ N P S ++AE A V R+ D KM R+ WA
Sbjct: 81 VDNIDMDKAKELGFEITNVPVYSPDAIAEHAAIQAARVLRQDKRMDEKMAKRDLRWAP-- 138
Query: 135 AMGIELEGKTLGIIGFGRIGYQVAKIARALGMNLLLYDPYPNEERAKEVGGKFVD-LETL 193
+G E+ + +G++G G IG KI G ++ YD + N E K+ G +VD L+ L
Sbjct: 139 TIGREVRDQVVGVVGTGHIGQVFMKIMEGFGAKVIAYDIFKNPELEKK--GYYVDSLDDL 196
Query: 194 LRESDIVTIHVPLLESTYHLINEERLKLMKKSAILINTSRGAVVDTNALVKALEEGWIAG 253
+++D++++HVP + + H+IN+E + MK +++N SRG +VDT+A+++ L+ G I G
Sbjct: 197 YKQADVISLHVPDVPANVHMINDESIAKMKDGVVIVNCSRGPLVDTDAVIRGLDSGKIFG 256
Query: 254 AGLDVYEEE-------------PLPKDHPLTKFDNVVLTPHIGASTVEAQERAGVEVAEK 300
+D YE E P + L NV++TPH T A + +
Sbjct: 257 FVMDTYEGEVGVFNEDWEGKEFPDARLADLIDRPNVLVTPHTAFYTTHAVRNMVTKAFDN 316
Query: 301 VVKILKG 307
+K++ G
Sbjct: 317 NLKMING 323
>gi|6324964 similar to formate dehydrogenases; Fdh1p [Saccharomyces cerevisiae]
>gi|2117510|pir||S67300 probable membrane protein
YOR388c - yeast (Saccharomyces cerevisiae)
>gi|1420835|emb|CAA99720.1| (Z75296) ORF YOR388c
[Saccharomyces cerevisiae]
Length = 376
Score = 138 bits (345), Expect = 6e-32
Identities = 97/303 (32%), Positives = 156/303 (51%), Gaps = 33/303 (10%)
Query: 20 LKDAGLEVI--YEEYPEEDRLVEL-VKDVEAIIVRS--KPKVTRKVIESAPKLKVIARAG 74
+++ G E++ ++ PE V+ +KD E +I ++R I AP LK+ AG
Sbjct: 37 IEEQGYELVTTIDKDPEPTSTVDRELKDAEIVITTPFFPAYISRNRIAEAPNLKLCVTAG 96
Query: 75 VGLDNIDVEAAKERGIEVVNAPAASSRSVAELAVALMFAVARKIAFADRKMREGVW---- 130
VG D++D+EAA ER I V ++ SVAE +A + + R ++ G W
Sbjct: 97 VGSDHVDLEAANERKITVTEVTGSNVVSVAEHVMATILVLIRNYNGGHQQAINGEWDIAG 156
Query: 131 -AKKQAMGIELEGKTLGIIGFGRIGYQVAKIARALGMNLLLYDPYPN---------EERA 180
AK + +LE K + +G GRIGY+V + A LLY Y E +
Sbjct: 157 VAKNE---YDLEDKIISTVGAGRIGYRVLERLVAFNPKKLLYYDYQELPAEAINRLNEAS 213
Query: 181 KEVGGK------FVDLETLLRESDIVTIHVPLLESTYHLINEERLKLMKKSAILINTSRG 234
K G+ LE ++ +SD+VTI+ PL + + L N++ + MK A L+NT+RG
Sbjct: 214 KLFNGRGDIVQRVEKLEDMVAQSDVVTINCPLHKDSRGLFNKKLISHMKDGAYLVNTARG 273
Query: 235 AVVDTNALVKALEEGWIAGAGLDVYEEEPLPKDHPLTKFDNV-----VLTPHIGASTVEA 289
A+ + +A++ G +AG G DV++++P PKDHP DN +T HI ++++A
Sbjct: 274 AICVAEDVAEAVKSGKLAGYGGDVWDKQPAPKDHPWRTMDNKDHVGNAMTVHISGTSLDA 333
Query: 290 QER 292
Q+R
Sbjct: 334 QKR 336
>sp|Q47748|VANH_ENTFA D-SPECIFIC ALPHA-KETO ACID DEHYDROGENASE (VANCOMYCIN B-TYPE
RESISTANCE PROTEIN VANHB) >gi|1209530|gb|AAB05626.1|
(U35369) D-2-hydroxyacid dehydrogenase [Enterococcus
faecalis]
Length = 323
Score = 138 bits (344), Expect = 8e-32
Identities = 98/273 (35%), Positives = 137/273 (49%), Gaps = 26/273 (9%)
Query: 46 EAIIVRSKPKVTRKVIESAPKL--KVIARAGVGLDNIDVEAAKERGIEVVNAPAASSRSV 103
+ I V K +V+ I + K+ K I+ +G ++ID AA+ GI V A S SV
Sbjct: 50 QCISVGHKSEVSEATILALRKVGVKYISTRSIGCNHIDTTAAERMGISV-GTVAYSPDSV 108
Query: 104 AELAVALMFAVARKIAFADRKMREGVWAKKQAMGIELEGKTLGIIGFGRIGYQVAKIARA 163
A+ A+ LM R + + + G EL T+G+IG G IG V K R
Sbjct: 109 ADYALMLMLMAIRGAKSTIHAVAQQNFRLDCVRGKELRDMTVGVIGTGHIGQAVVKRLRG 168
Query: 164 LGMNLLLYDPYPNEERAKEVGGKFVDLETLLRESDIVTIHVPLLESTYHLINEERLKLMK 223
G +L YD ++++ +V L+ LL+ SDIVT+HVPL T HLI + + MK
Sbjct: 169 FGCRVLAYD------NSRKIEADYVQLDELLKNSDIVTLHVPLCADTRHLIGQSEIGEMK 222
Query: 224 KSAILINTSRGAVVDTNALVKALEEGWIAGAGLDVYEEE---------PLPKDHP----L 270
+ A LINT RGA+VDT +LV+AL G + GA LDV E E DHP L
Sbjct: 223 QGAFLINTGRGALVDTGSLVEALGSGKLGGAALDVLEGEDQFVYTDCSQKVLDHPFLSQL 282
Query: 271 TKFDNVVLTPHIGASTVEAQERAGVEVAEKVVK 303
+ NV++TPH T ER + EK ++
Sbjct: 283 LRMPNVIITPH----TAYYTERVLRDTTEKTIR 311
>gb|AAC23583.1| (U82965) D-lactate dehydrogenase [Streptomyces toyocaensis]
Length = 330
Score = 138 bits (344), Expect = 8e-32
Identities = 94/281 (33%), Positives = 143/281 (50%), Gaps = 19/281 (6%)
Query: 24 GLEVIYEEYPEEDRLVELVKDVEAIIVRSKPKVTRKVIESAPKLKV--IARAGVGLDNID 81
G++ + + P + EL + + K VT + + ++ V I+ +G ++ID
Sbjct: 30 GVQPVITDAPVSEANSELALGSRCVSISHKTPVTHATLRALGRVGVGYISTRSIGYNHID 89
Query: 82 VEAAKERGIEVVNAPAASSRSVAELAVALMFAVARKIAFADRKMREGVWAKKQAMGIELE 141
VE A GI V N + S SVA+ + LM V R R+ + + G EL
Sbjct: 90 VEYADSIGIVVENV-SYSPDSVADYTLMLMLMVLRDAKAIVRRTDMHDYRLSEVRGKELR 148
Query: 142 GKTLGIIGFGRIGYQVAKIARALGMNLLLYDPYPNEERAKEVGGKFVDLETLLRESDIVT 201
T+G++G GRIG V R G +L +D +P + ++V L+ LLR SD+VT
Sbjct: 149 DLTVGVVGTGRIGTAVLDRLRGFGCRVLAHDNHPADRPGV---AEYVPLDELLRRSDVVT 205
Query: 202 IHVPLLESTYHLINEERLKLMKKSAILINTSRGAVVDTNALVKALEEGWIAGAGLDVYE- 260
+H PL +T+HL++++RL MK A++INT RG ++DT ALV LE G + GA LDV E
Sbjct: 206 LHAPLTTATHHLLDQQRLARMKDGALVINTGRGGLIDTEALVHELESGRLGGAALDVVEG 265
Query: 261 EEPL----PKDHP--------LTKFDNVVLTPHIGASTVEA 289
EE + +D P L + N ++TPH T A
Sbjct: 266 EEGIFYADCRDRPMESKALLRLQELPNALITPHTAYYTDHA 306
>pir||D82435 D-3-phosphoglycerate dehydrogenase-related protein VCA0630
[imported] - Vibrio cholerae (group O1 strain N16961)
>gi|9658044|gb|AAF96531.1| (AE004393)
D-3-phosphoglycerate dehydrogenase-related protein
[Vibrio cholerae]
Length = 323
Score = 138 bits (344), Expect = 8e-32
Identities = 85/293 (29%), Positives = 153/293 (52%), Gaps = 6/293 (2%)
Query: 16 AIQILKDAGLEVIYEEYPEEDRLVELVKDVEAII-VRSKPKVTRKVIESAPKLKVIARAG 74
A Q L+ + V + +E L+E +K EA++ +R + +T ++ P LK+I++ G
Sbjct: 18 AFQCLQGHDVTVFNDSLSDETVLIERLKPFEALVLIRERTPITENLLAHLPNLKLISQTG 77
Query: 75 VGLDNIDVEAAKERGIEVVNAPAASSRSVAELAVALMFAVARKIAFADRKMREGVWAKKQ 134
++IDV + G+ V+ S + AEL L+ A +R + ++ G W +
Sbjct: 78 KVSNHIDVALCERYGVTVLEG-IGSPVAPAELCWGLILAASRHLPSYIEQLHAGHWQQNG 136
Query: 135 AMGI--ELEGKTLGIIGFGRIGYQVAKIARALGMNLLLYDPYPNEERAKEVGGKFV-DLE 191
+G+ L G TLGI G G+IG ++A+ GM +L++ + ++A E+G + D
Sbjct: 137 GLGLGRTLSGHTLGIWGLGKIGQRIAQFGHVFGMPILVWGSEASRQKALELGYQAAADKA 196
Query: 192 TLLRESDIVTIHVPLLESTYHLINEERLKLMKKSAILINTSRGAVVDTNALVKALEEGWI 251
++D++++H+ L ++T ++ ++ L MK ++ +NTSR +V++ AL ++
Sbjct: 197 EFFAKADVLSLHLRLNDATRGIVTKQDLLAMKPDSLFVNTSRAELVESGALYSVMQTNPT 256
Query: 252 AGAGLDVYEEEP-LPKDHPLTKFDNVVLTPHIGASTVEAQERAGVEVAEKVVK 303
A +DVYE EP LP + PL NV+ PH+G + E E VVK
Sbjct: 257 RQAAVDVYENEPALPNNEPLLSLPNVLCAPHLGYVEKNSYEIYFQAAFENVVK 309
>gb|AAD19834.1| (AF060799) D-lactate dehydrogenase [Amycolatopsis orientalis]
Length = 348
Score = 138 bits (343), Expect = 1e-31
Identities = 94/272 (34%), Positives = 135/272 (49%), Gaps = 22/272 (8%)
Query: 33 PEEDRLVELVKDVEAIIVRSKPKVTRKVIESAPKLKV--IARAGVGLDNIDVEAAKERGI 90
P + + LV I + K KVT ++ + + V I+ +G ++IDVE A GI
Sbjct: 60 PVSEANIGLVSGNRCISIGHKTKVTNSILLALAEAGVEYISTRSIGFNHIDVEYAASVGI 119
Query: 91 EVVNAPAASSRSVAELAVALMFAVARKIAFADRKMREGVWAKKQAMGIELEGKTLGIIGF 150
V N A S SVA+ + LM R R+ + + G EL T+G++G
Sbjct: 120 TVGNV-AYSPDSVADFTLMLMLMAVRDAKSIIRRTEVHDYRLNEVRGKELRDLTVGVVGT 178
Query: 151 GRIGYQVAKIARALGMNLLLYDPYPNEERAKEVGGKFVDLETLLRESDIVTIHVPLLEST 210
GRIG V R G +L YD +V L+ LL++SDIVT+HVPL T
Sbjct: 179 GRIGVAVLDRLRGFGCRVLAYDTLLT------ASADYVPLDELLQQSDIVTLHVPLNNDT 232
Query: 211 YHLINEERLKLMKKSAILINTSRGAVVDTNALVKALEEGWIAGAGLDVYEEE-------- 262
YHL++ + ++ MK A +INT RG +++T AL+ ALE+G + GA LDV E E
Sbjct: 233 YHLLDRKNIERMKDGAYIINTGRGPLIETEALISALEDGKLGGAALDVVEGEEGIFYADC 292
Query: 263 ---PLPKDH--PLTKFDNVVLTPHIGASTVEA 289
PL + L K NV+++PH T A
Sbjct: 293 RNKPLESETLLRLEKLPNVLISPHTAYYTDHA 324
>sp|P30901|LDHD_LACHE D-LACTATE DEHYDROGENASE (D-LDH) >gi|478777|pir||S29296 D-lactate
dehydrogenase (EC 1.1.1.28) - Lactobacillus helveticus
>gi|1431687|pdb|2DLD|A Chain A, D-Lactate Dehydrogenase
Complexed With Nadh And Oxamate >gi|1431688|pdb|2DLD|B
Chain B, D-Lactate Dehydrogenase Complexed With Nadh And
Oxamate >gi|43997|emb|CAA47255.1| (X66723) D-lactate
dehydrogenase [Lactobacillus helveticus]
>gi|520453|gb|AAA20464.1| (U07604) D-lactate
dehydrogenase [Lactobacillus helveticus]
>gi|1095459|prf||2109198A D-lactate dehydrogenase
[Lactobacillus helveticus]
Length = 337
Score = 137 bits (342), Expect = 1e-31
Identities = 87/301 (28%), Positives = 153/301 (49%), Gaps = 22/301 (7%)
Query: 25 LEVIYEEYPEEDRLVELVKDVEAIIVRSKPKVTRKVIESAPKLKV--IARAGVGLDNIDV 82
++V Y + +L K + ++V + T +++ V ++ VG+DNID+
Sbjct: 27 IDVDYTDKLLTPETAKLAKGADGVVVYQQLDYTADTLQALADAGVTKMSLRNVGVDNIDM 86
Query: 83 EAAKERGIEVVNAPAASSRSVAELAVALMFAVARKIAFADRKM--REGVWAKKQAMGIEL 140
+ AKE G ++ N P S ++AE A V R+ D KM R+ WA +G E+
Sbjct: 87 DKAKELGFQITNVPVYSPNAIAEHAAIQAARVLRQDKRMDEKMAKRDLRWAP--TIGREV 144
Query: 141 EGKTLGIIGFGRIGYQVAKIARALGMNLLLYDPYPNEERAKEVGGKFVD-LETLLRESDI 199
+ +G++G G IG +I G ++ YD + N E K+ G +VD L+ L +++D+
Sbjct: 145 RDQVVGVVGTGHIGQVFMRIMEGFGAKVIAYDIFKNPELEKK--GYYVDSLDDLYKQADV 202
Query: 200 VTIHVPLLESTYHLINEERLKLMKKSAILINTSRGAVVDTNALVKALEEGWIAGAGLDVY 259
+++HVP + + H+IN++ + MK +++N SRG +VDT+A+++ L+ G I G +D Y
Sbjct: 203 ISLHVPDVPANVHMINDKSIAEMKDGVVIVNCSRGRLVDTDAVIRGLDSGKIFGFVMDTY 262
Query: 260 EEE-------------PLPKDHPLTKFDNVVLTPHIGASTVEAQERAGVEVAEKVVKILK 306
E+E P + L NV++TPH T A V+ +K++
Sbjct: 263 EDEVGVFNKDWEGKEFPDKRLADLIDRPNVLVTPHTAFYTTHAVRNMVVKAFNNNLKLIN 322
Query: 307 G 307
G
Sbjct: 323 G 323
>gb|AAF72362.1|AF192329_23 (AF192329) VanHB [Enterococcus faecalis]
Length = 323
Score = 137 bits (341), Expect = 2e-31
Identities = 93/250 (37%), Positives = 130/250 (51%), Gaps = 24/250 (9%)
Query: 67 LKVIARAGVGLDNIDVEAAKERGIEVVNAPAASSRSVAELAVALMFAVARKIAFADRKMR 126
+K I+ +G D+ID AA+ GI V A S SVA+ A+ LM R +
Sbjct: 73 VKYISTRSIGCDHIDTTAAERMGISV-GTVAYSPDSVADYALMLMLMAIRGAKPTMHAVA 131
Query: 127 EGVWAKKQAMGIELEGKTLGIIGFGRIGYQVAKIARALGMNLLLYDPYPNEERAKEVGGK 186
+ + + G EL T+ +IG G IG V K R G ++L YD ++++
Sbjct: 132 QQDFRLDRIRGKELGDMTVRVIGTGHIGQAVVKRLRGFGCHVLAYD------NSRKMDAD 185
Query: 187 FVDLETLLRESDIVTIHVPLLESTYHLINEERLKLMKKSAILINTSRGAVVDTNALVKAL 246
+V L+ LL+ S IVT+HVPL T HLI ++++ MK+ A LINT RGA+VDT ALV+AL
Sbjct: 186 YVQLDELLKNSGIVTLHVPLCADTRHLIGQKQIGEMKQGAFLINTGRGALVDTGALVEAL 245
Query: 247 EEGWIAGAGLDVYEEE---------PLPKDHP----LTKFDNVVLTPHIGASTVEAQERA 293
E G + GA LDV E E DHP L + NV++TPH T ER
Sbjct: 246 ESGKLGGAALDVLEGEDQFVYTDCSQKVLDHPFLSQLLRMPNVIITPH----TAYYTERV 301
Query: 294 GVEVAEKVVK 303
+ EK ++
Sbjct: 302 LQDTTEKTIR 311
>sp|P26297|LDHD_LACDE D-LACTATE DEHYDROGENASE (D-LDH) >gi|538959|pir||A38094 D-lactate
dehydrogenase (EC 1.1.1.28) - Lactobacillus delbrueckii
subsp. bulgaricus >gi|149577|gb|AAA25246.1| (M85224)
D-lactate dehydrogenase [Lactobacillus delbrueckii]
Length = 333
Score = 136 bits (339), Expect = 3e-31
Identities = 82/299 (27%), Positives = 153/299 (50%), Gaps = 18/299 (6%)
Query: 25 LEVIYEEYPEEDRLVELVKDVEAIIVRSKPKVTRKVIESAPK--LKVIARAGVGLDNIDV 82
+EV Y + L K + ++V + T + +++ + ++ VG+DNID+
Sbjct: 27 VEVEYTDKLLTPETAALAKGADGVVVYQQLDYTAETLQALADNGITKMSLRNVGVDNIDM 86
Query: 83 EAAKERGIEVVNAPAASSRSVAELAVALMFAVARKIAFADRKMREGVWAKKQAMGIELEG 142
AKE G ++ N P S ++AE A + R+ D K+ +G E+
Sbjct: 87 AKAKELGFQITNVPVYSPNAIAEHAAIQAARILRQAKAMDEKVARHDLRWAPTIGREVRD 146
Query: 143 KTLGIIGFGRIGYQVAKIARALGMNLLLYDPYPNEERAKEVGGKFVD-LETLLRESDIVT 201
+ +G++G G IG +I G ++ YD + N E K+ G +VD L+ L +++D+++
Sbjct: 147 QVVGVVGTGHIGQVFMQIMEGFGAKVIAYDIFRNPELEKK--GYYVDSLDDLYKQADVIS 204
Query: 202 IHVPLLESTYHLINEERLKLMKKSAILINTSRGAVVDTNALVKALEEGWIAGAGLDVYE- 260
+HVP + + H+IN++ + MK+ +++N SRG +VDT+A+++ L+ G + G +DVYE
Sbjct: 205 LHVPDVPANVHMINDKSIAKMKQDVVIVNVSRGPLVDTDAVIRGLDSGKVFGYAMDVYEG 264
Query: 261 ------EEPLPKDHP------LTKFDNVVLTPHIGASTVEAQERAGVEVAEKVVKILKG 307
E+ K+ P L NV++TPH T A V+ + +++++G
Sbjct: 265 EVGVFNEDREGKEFPDARLADLIARPNVLVTPHTAFYTTHAVRNMVVKAFDNNLELVEG 323
>prf||2124425A CtBP protein [Rattus norvegicus]
Length = 439
Score = 136 bits (338), Expect = 4e-31
Identities = 90/297 (30%), Positives = 148/297 (49%), Gaps = 8/297 (2%)
Query: 19 ILKDAGLEVIYEEYPEEDRLVELVKDVEAIIVRSKPKVTRKVIESAPKLKVIARAGVGLD 78
ILKD + ++ +++ + ++ +TR+ +E L++I R G G D
Sbjct: 44 ILKDVATVAFCDAQSTQEIHEKVLNEAVGALMYHTITLTREDLEKFKALRIIVRIGSGFD 103
Query: 79 NIDVEAAKERGIEVVNAPAASSRSVAELAVALMFAVARKIAFADRKMREGVWAKKQAMGI 138
NID+++A + GI V N PAAS A+ + + + R+ R+ ++ +
Sbjct: 104 NIDIKSAGDLGIAVCNVPAASVEETADSTLCHILNLYRRATGCTRRCGRAHESRASSRSA 163
Query: 139 ELEGKTL---GIIGFGRI---GYQVAKIARALGMNLLLYDPYPNEERAKEVGGKFVD-LE 191
+ G +G R G + +G N+L YDPY ++ + +G + V L+
Sbjct: 164 RWRPRCQDPRGDLGHHRTWSRGAGSGAAGQRVGFNVLFYDPYLSDGVERALGLQRVSTLQ 223
Query: 192 TLLRESDIVTIHVPLLESTYHLINEERLKLMKKSAILINTSRGAVVDTNALVKALEEGWI 251
LL SD VT+H L E +HLIN+ +K M++ A L+NT+RG +VD AL +AL+EG I
Sbjct: 224 DLLFHSDCVTLHCGLNEHNHHLINDFTVKQMRQGAFLVNTARGGLVDEKALAQALKEGRI 283
Query: 252 AGAGLDVYEEEPLP-KDHPLTKFDNVVLTPHIGASTVEAQERAGVEVAEKVVKILKG 307
GA LDV+E EP PL N++ TPH + +A E A ++ + + G
Sbjct: 284 RGAALDVHESEPFSFSQGPLKDAPNLICTPHAAWYSEQASIEMREEAAREIRRAITG 340
>pir||T35362 probable D-lactate dehydrogenase - Streptomyces coelicolor
>gi|5123869|emb|CAB45461.1| (AL079348) putative
D-lactate dehydrogenase [Streptomyces coelicolor A3(2)]
Length = 337
Score = 134 bits (333), Expect = 2e-30
Identities = 94/284 (33%), Positives = 134/284 (47%), Gaps = 28/284 (9%)
Query: 24 GLEVIYEEYPEEDRLVELVKDVEAIIVRSKPKVTRKVIESAPKLKV--IARAGVGLDNID 81
G+E E + E+ + I + K VT + + + V I+ +G ++ID
Sbjct: 42 GVEATLTEAAVSEENAEMAAGNQCISIDHKTPVTPATLRALHRAGVTYISTRSIGYNHID 101
Query: 82 VEAAKERGIEVVNAPAASSRSVAELAVALMFAVARKIAFADRKMREGVWAKKQAMGIELE 141
V A GI V N S VA+ + LM R R+ + + G EL
Sbjct: 102 VTYAAGVGISVENV-TYSPAGVADYTLMLMLMAVRNAKSTVRRAELHDYRLNEIRGKELR 160
Query: 142 GKTLGIIGFGRIGYQVAKIARALGMNLLLYDPYPNEERAKEVGGKFVDLETLLRESDIVT 201
T+G+IG GRIG V R G +L Y P + +V L+ LLR SDIV+
Sbjct: 161 DLTVGVIGTGRIGAAVVDRLRGFGSRVLAYGKRPT------IAADYVSLDELLRSSDIVS 214
Query: 202 IHVPLLESTYHLINEERLKLMKKSAILINTSRGAVVDTNALVKALEEGWIAGAGLDVYEE 261
+HVPL T+HL+++ R++ MK A +INT RG ++DT ALV ALE G ++GA LDV E
Sbjct: 215 LHVPLTPDTHHLLDQSRIRRMKSGAFVINTGRGPLIDTEALVPALESGRLSGAALDVIEG 274
Query: 262 EP----------------LPKDHPLTKFDNVVLTPHIGASTVEA 289
E LP+ L K NV+++PH T A
Sbjct: 275 EEGIFYADCRNRTIESTWLPR---LQKMPNVLISPHTAYYTDHA 315
>gb|AAC71709.1| (AF061070) PtxD [Pseudomonas stutzeri]
Length = 336
Score = 132 bits (330), Expect = 4e-30
Identities = 88/316 (27%), Positives = 158/316 (49%), Gaps = 14/316 (4%)
Query: 5 KVLVAAPLHEKAIQILKDAGLEVIYEEYPE---EDRLVELVKDVEAIIVRSKPKVTRKVI 61
K+++ +H++ +Q+L E++ + + ++ +D +A++ +V +
Sbjct: 4 KLVITHRVHDEILQLLAPH-CELMTNQTDSTLTREEILRRCRDAQAMMAFMPDRVDADFL 62
Query: 62 ESAPKLKVIARAGVGLDNIDVEAAKERGIEVVNAPAASSRSVAELAVALMFAVARKIAFA 121
++ P+L+V+ A G DN DV+A RG+ + P + AELA+ L + R + A
Sbjct: 63 QACPELRVVGCALKGFDNFDVDACTARGVWLTFVPDLLTVPTAELAIGLAVGLGRHLRAA 122
Query: 122 DRKMREGVWA--KKQAMGIELEGKTLGIIGFGRIGYQVAKIARALGMNLLLYDPYPNEER 179
D +R G + + Q G L+ T+GI+G G IG +A + G L ++ + +
Sbjct: 123 DAFVRSGEFQGWQPQFYGTGLDNATVGILGMGAIGLAMADRLQGWGATLQYHEAKALDTQ 182
Query: 180 AKE-VGGKFVDLETLLRESDIVTIHVPLLESTYHLINEERLKLMKKSAILINTSRGAVVD 238
++ +G + V L SD + + +PL T HL+N E L L++ A+L+N RG+VVD
Sbjct: 183 TEQRLGLRQVACSELFASSDFILLALPLNADTQHLVNAELLALVRPGALLVNPCRGSVVD 242
Query: 239 TNALVKALEEGWIAGAGLDVYEEE-------PLPKDHPLTKFDNVVLTPHIGASTVEAQE 291
A++ ALE G + G DV+E E P D L N + TPHIG++ +
Sbjct: 243 EAAVLAALERGQLGGYAADVFEMEDWARADRPRLIDPALLAHPNTLFTPHIGSAVRAVRL 302
Query: 292 RAGVEVAEKVVKILKG 307
A+ ++++L G
Sbjct: 303 EIERCAAQNIIQVLAG 318
>pir||C83473 erythronate-4-phosphate dehydrogenase PA1375 [imported] -
Pseudomonas aeruginosa (strain PAO1)
>gi|9947319|gb|AAG04764.1|AE004567_3 (AE004567)
erythronate-4-phosphate dehydrogenase [Pseudomonas
aeruginosa]
Length = 380
Score = 132 bits (330), Expect = 4e-30
Identities = 84/294 (28%), Positives = 152/294 (51%), Gaps = 37/294 (12%)
Query: 17 IQILKDAGLEVIYEEYPEEDRLVEL---------VKDVEAIIVRSKPKVTRKVIESAPKL 67
++IL D + V+ + ++ + L + +V+ ++VRS +V+R + +P +
Sbjct: 1 MRILADENIPVVDAFFADQGSIRRLPGRAIDRAALAEVDVLLVRSVTEVSRAALAGSP-V 59
Query: 68 KVIARAGVGLDNIDVEAAKERGIEVVNAPAASSRSVAELAVALMFAVARKIAFADRKMRE 127
+ + +G D++D++ E GI +AP ++R V + + + A+A
Sbjct: 60 RFVGTCTIGTDHLDLDYFAEAGIAWSSAPGCNARGVVDYVLGCLLAMA------------ 107
Query: 128 GVWAKKQAMGIELEGKTLGIIGFGRIGYQVAKIARALGMNLLLYDPYPNEERAKEVGGKF 187
+ G +L +T G++G G++G ++ ++ R LG +L+ DP +A+E G+F
Sbjct: 108 ------EVRGADLAERTYGVVGAGQVGGRLVEVLRGLGWKVLVCDP---PRQAREPDGEF 158
Query: 188 VDLETLLRESDIVTIHVPLLES----TYHLINEERLKLMKKSAILINTSRGAVVDTNALV 243
V LE LL E+D++++H PL T HL++E RL ++ L+N SRGAVVD AL
Sbjct: 159 VSLERLLAEADVISLHTPLNRDGEHPTRHLLDEPRLAALRPGTWLVNASRGAVVDNQALR 218
Query: 244 KALEEGWIAGAGLDVYEEEPLPKDHPLTKFDNVVLTPHIGASTVEAQERAGVEV 297
+ LE G LDV+E E P+ P ++ TPHI ++E + R ++
Sbjct: 219 RLLEGGADLEVALDVWEGE--PQADPELAARCLIATPHIAGYSLEGKLRGTAQI 270
>gb|AAF53929.1| (AE003668) CG9331 gene product [Drosophila melanogaster]
Length = 248
Score = 132 bits (329), Expect = 5e-30
Identities = 84/238 (35%), Positives = 127/238 (53%), Gaps = 7/238 (2%)
Query: 76 GLDNIDVEAAKERGIEVVNAPAASSRSVAELAVALMFAVARKIAFADRKMREGVWAKKQA 135
G+D +DV K R I + + P + +VA+LAV L+ A +R+ + + W
Sbjct: 4 GIDYVDVPEVKRRKIPLGHTPTVLNTAVADLAVGLLIAASRRFHEGRKTIDNDKWENYHL 63
Query: 136 ---MGIELEGKTLGIIGFGRIGYQVAKIARALGMNLLLYDPYP--NEERAKEVGGKFVDL 190
+G ++ T+G GFG IG +AK ++ +LY ++E +E K VD
Sbjct: 64 NWLLGQDIRDSTVGFYGFGGIGQAIAKRLSGFDIDKVLYTTRRRVHKEIEEEFNAKKVDF 123
Query: 191 ETLLRESDIVTIHVPLLESTYHLINEERLKLMKKSAILINTSRGAVVDTNALVKALEEGW 250
+TLL ESD V I PL + T + N MK++A+L+N +RG +V+ + L +AL+
Sbjct: 124 DTLLAESDFVVIASPLTKDTQGVFNATAFNKMKQTAVLVNIARGKIVNQDDLYEALKANR 183
Query: 251 IAGAGLDVYEEEPL-PKDHPLTKFDNVVLTPHIGASTVEAQERAGVEVAEKVVKILKG 307
I AGLDV + EPL PKD LT DNVV+ PHIG++T + A V++ L G
Sbjct: 184 IFSAGLDVTDPEPLSPKDKLLT-LDNVVVLPHIGSATKRTRADMSTIAAHNVLRGLAG 240
>gb|AAG21503.1|AC067754_18 (AC067754) phosphoglycerate dehydrogenase, putative; 33424-31403
[Arabidopsis thaliana]
Length = 344
Score = 132 bits (329), Expect = 5e-30
Identities = 80/277 (28%), Positives = 147/277 (52%), Gaps = 12/277 (4%)
Query: 40 ELVKDVEAIIVRSKPKVTRKVIESAPKLKVIARAGVGLDNIDVEAAKERGIEVVNAPA-- 97
E++K+ I V ++ VI A +K+I + GVGLD +D++AA + GI+V P+
Sbjct: 61 EVIKNYH-ICVAMTMQMDSNVISRASNIKLIMQYGVGLDGVDIDAATKHGIKVARIPSEG 119
Query: 98 -ASSRSVAELAVALMFAVARKIAFADRKMREGVWAKKQAMGIELEGKTLGIIGFGRIGYQ 156
++ S +E+A+ LM + +K +R + + G L GKT+ I+G+G IG +
Sbjct: 120 TGNAASCSEMAIYLMLGLLKKQNEMQISLRNRLLG--EPTGDTLLGKTVFILGYGNIGIE 177
Query: 157 VAKIARALGMNLLLYDPY------PNEERAKEVGGKFVDLETLLRESDIVTIHVPLLEST 210
+AK + G ++ + ++ R + G D+ T ++DIV + + L + T
Sbjct: 178 LAKRLKPFGSRVIATKRFWPASIVDSDSRLVDEKGSHEDIYTFAGKADIVVVCLRLNKET 237
Query: 211 YHLINEERLKLMKKSAILINTSRGAVVDTNALVKALEEGWIAGAGLDVYEEEPLPKDHPL 270
++N+E + MKK A+L+N +RG +++ + + LE G + G G+DV EP + P+
Sbjct: 238 AEIVNKEFICSMKKGALLVNIARGGLINYESAFQNLESGHLGGLGIDVAWSEPFDPNDPI 297
Query: 271 TKFDNVVLTPHIGASTVEAQERAGVEVAEKVVKILKG 307
KF NV++TPH+ T + V + +++ +G
Sbjct: 298 LKFKNVIITPHVAGVTEYSYRSMAKIVGDLALQLHEG 334
>pir||T34290 hypothetical protein F49E10.5 - Caenorhabditis elegans
>gi|1255868|gb|AAC69109.1| (U53341) similar to the
D-isomer specific 2-hdroxyacid dehydrogenases family
[Caenorhabditis elegans]
Length = 612
Score = 132 bits (328), Expect = 6e-30
Identities = 89/312 (28%), Positives = 150/312 (47%), Gaps = 32/312 (10%)
Query: 19 ILKDAGLEVIYEEYPEEDRLVELVKDVEAIIVRSKPKVTRKVIESAPKLKVIARAGVGLD 78
ILKD + ++ +++ + A ++ K+ ++ +E LKV+ R G G+D
Sbjct: 76 ILKDVATVAFCDAQSTQEIHEKVLNEAVAALMYHSIKLEKEDLEKFKVLKVVFRIGYGID 135
Query: 79 NIDVEAAKERGIEVVNAPAASSRSVAELAVALM-------------FAVARKIAFADRKM 125
NIDV+AA E GI V +AP VA+ ++L+ ++ RK AD+
Sbjct: 136 NIDVKAATELGIAVCHAPGDYVEDVADSTLSLILDLFRRTYWHAKSYSETRKTIGADQVR 195
Query: 126 REGVWAKKQAMGIELEGKTLGIIGFGRIGYQVAKIARALGMNLLLYDPYPNEERAKEVGG 185
V +KK + G LGI+G GR+G V ARA G++++ YDP+ E K
Sbjct: 196 ENAVGSKK------VRGSVLGILGCGRVGTAVGLRARAFGLHIIFYDPFVREGHDK---A 246
Query: 186 KFVDLE--------TLLRESDIVTIHVPLLESTYHLINEERLKLMKKSAILINTSRGAVV 237
DLE + SD +++H L + T +IN + L+ K ++NTS ++
Sbjct: 247 SVTDLELFRVYTMDEFMSRSDCISLHCNLGDETRGIINADSLRQCKSGVYIVNTSHAGLI 306
Query: 238 DTNALVKALEEGWIAGAGLDVYEEEPLPKD--HPLTKFDNVVLTPHIGASTVEAQERAGV 295
+ N L AL+ G + GA LDV++ + +PL N++ TPH T + + +
Sbjct: 307 NENDLAAALKNGHVKGAALDVHDSVRFDPNCLNPLVGCPNIINTPHSAWMTEASCKDLRI 366
Query: 296 EVAEKVVKILKG 307
A+++ K + G
Sbjct: 367 NAAKEIRKAING 378
>emb|CAA21970.1| (AL033497) YNL274C homologue [Candida albicans]
Length = 342
Score = 132 bits (328), Expect = 6e-30
Identities = 85/281 (30%), Positives = 137/281 (48%), Gaps = 18/281 (6%)
Query: 26 EVIYEEYPEEDRLVELVK----DVEAII-----VRSKPKVTRKVIESAPK-LKVIARAGV 75
EVI E ++ ++ +K D+ I + + + + PK LK ++ G
Sbjct: 31 EVIQSESTTREQFIQDLKTKYNDITCIARTFYSINETGRFDADLAQHMPKTLKSVSHCGA 90
Query: 76 GLDNIDVEAAKERGIEVVNAPAASSRSVAELAVALMFAVARKIAFADRKMREGVWAK--- 132
G D +DVE G++V N R A++AV L+ A R + + G W
Sbjct: 91 GYDQVDVEPFTRLGVQVSNVTEPVERPTADVAVFLVLACMRNFLQGRQILMNGEWPSNGD 150
Query: 133 KQAMGIEL----EGKTLGIIGFGRIGYQVAKIARALGMNLLLYDPYPNEERAKEVGGKFV 188
K+A G L +GK +GI+G G IG + + G + ++Y E G ++V
Sbjct: 151 KEAAGAPLGHTPQGKVVGILGMGGIGRAIRDRLKPFGFDRIVYYNRKQLSSELEKGAEYV 210
Query: 189 DLETLLRESDIVTIHVPLLESTYHLINEERLKLMKKSAILINTSRGAVVDTNALVKALEE 248
++ L ++SD++ I VPL T HLI++E ++ MK +L+N +RGA++D L + ++
Sbjct: 211 TMDELFKQSDVIIIGVPLNAKTRHLIDKEAIQKMKDGVVLVNIARGAIIDEKHLPELIKS 270
Query: 249 GWIAGAGLDVYEEEPLPKDHPLTKFDNVVLTPHIGASTVEA 289
G I G DV+E EP L NVV PH+G +VEA
Sbjct: 271 GKIGAFGADVFEHEP-EVSPELVNLPNVVALPHMGTHSVEA 310
>sp|P51011|LDHD_LEUMC D-LACTATE DEHYDROGENASE (D-LDH) >gi|508506|gb|AAA99506.1| (L29327)
D-lactate dehydrogenase [Leuconostoc mesenteroides]
Length = 331
Score = 130 bits (324), Expect = 2e-29
Identities = 85/283 (30%), Positives = 146/283 (51%), Gaps = 22/283 (7%)
Query: 25 LEVIYEEYPEEDRLVELVKDVEAIIVRSKPKVTRKVIESAPKLKV--IARAGVGLDNIDV 82
+EV Y + +L + ++ +V + TR+ + + + V ++ VG DNID
Sbjct: 26 IEVDYTQELLTPETAKLAEGSDSAVVYQQLDYTRETLTALANVGVTNLSLRNVGTDNIDF 85
Query: 83 EAAKERGIEVVNAPAASSRSVAELAVALMFAVARKIAFADRKM--REGVWAKKQAMGIEL 140
+AA+E + N P S ++AE ++ + + R+ D K+ R+ WA G E+
Sbjct: 86 DAAREFNFNISNVPVYSPNAIAEHSMLQLSRLLRRTKALDAKIAKRDLRWA--PTTGREM 143
Query: 141 EGKTLGIIGFGRIGYQVAKIARALGMNLLLYDPYPNEERAKEVGGKFVD-LETLLRESDI 199
+T+G+IG G IG I + G ++ YD YPN E E G +VD L+ L ++D
Sbjct: 144 RMQTVGVIGTGHIGRVAINILKGFGAKVIAYDKYPNAELQAE--GLYVDTLDELYAQADA 201
Query: 200 VTIHVPLLESTYHLINEERLKLMKKSAILINTSRGAVVDTNALVKALEEGWIAGAGLDVY 259
++++VP + +HLIN + + MK +++N +RG ++D +A++ L G I+ G+DVY
Sbjct: 202 ISLYVPGVPENHHLINADAIAKMKDGVVIMNAARGNLMDIDAIIDGLNSGKISDFGMDVY 261
Query: 260 EEE-------PLPKDHPLTKF------DNVVLTPHIGASTVEA 289
E E L K+ P K +NV++TPH T +A
Sbjct: 262 ENEVACSMKIGLVKNSPDAKIADLIARENVMITPHTAFYTTKA 304
>sp|P05459|PDXB_ECOLI ERYTHRONATE-4-PHOSPHATE DEHYDROGENASE >gi|65958|pir||DEECPP
probable erythronate-4-phosphate dehydrogenase (EC
1.1.1.-) - Escherichia coli >gi|147124|gb|AAA24308.1|
(M29962) erythronate-4-phosphate dehydrogenase
[Escherichia coli] >gi|1684788|gb|AAB36530.1| (U76961)
4-phosphoerythronate dehydrogenase [Escherichia coli]
>gi|1788660|gb|AAC75380.1| (AE000321)
erythronate-4-phosphate dehyrogenase [Escherichia coli
K12] >gi|1799713|dbj|BAA16177.1| (D90863) probable
erythronate-4-phosphate dehydrogenase (EC 1.1.1.-)
[Escherichia coli]
Length = 378
Score = 127 bits (316), Expect = 2e-28
Identities = 89/271 (32%), Positives = 134/271 (48%), Gaps = 28/271 (10%)
Query: 39 VELVKDVEAIIVRSKPKVTRKVIESAPKLKVIARAGVGLDNIDVEAAKERGIEVVNAPAA 98
V + D +A++VRS KV ++ P +K + A G D++D K+ GI AP
Sbjct: 32 VAQLADADALMVRSVTKVNESLLAGKP-IKFVGTATAGTDHVDEAWLKQAGIGFSAAPGC 90
Query: 99 SSRSVAELAVALMFAVARKIAFADRKMREGVWAKKQAMGIELEGKTLGIIGFGRIGYQVA 158
++ +V E + + +A + F+ L +T+GI+G G +G ++
Sbjct: 91 NAIAVVEYVFSSLLMLAERDGFS------------------LYDRTVGIVGVGNVGRRLQ 132
Query: 159 KIARALGMNLLLYDPYPNEERAKEVGGKFVDLETLLRESDIVTIHVPLLES----TYHLI 214
ALG+ LL DP P +R E G F L+ L++ +DI+T H PL + T HL
Sbjct: 133 ARLEALGIKTLLCDP-PRADRGDE--GDFRSLDELVQRADILTFHTPLFKDGPYKTLHLA 189
Query: 215 NEERLKLMKKSAILINTSRGAVVDTNALVKALEEGWIAGAGLDVYEEEPLPKDHPLTKFD 274
+E+ ++ +K AILIN RGAVVD AL+ L EG LDV+E EP L K D
Sbjct: 190 DEKLIRSLKPGAILINACRGAVVDNTALLTCLNEGQKLSVVLDVWEGEPELNVELLKKVD 249
Query: 275 NVVLTPHIGASTVEAQERAGVEVAEKVVKIL 305
+ T HI T+E + R +V E K +
Sbjct: 250 --IGTSHIAGYTLEGKARGTTQVFEAYSKFI 278
>emb|CAB55710.1| (AL117387) possible dehydrogenase [Streptomyces coelicolor A3(2)]
Length = 339
Score = 126 bits (314), Expect = 3e-28
Identities = 88/259 (33%), Positives = 132/259 (49%), Gaps = 6/259 (2%)
Query: 54 PKVTRKVIESAPKLKVIARAG-VGLDNIDVEAA-KERGIEVVNAPAASSRSVAELAVALM 111
P V + + +L+ + AG V ++ AA RG+ NA AA+S VAE +A++
Sbjct: 64 PVVRAEHLPGTERLRAVVYAGGVAATCLEDPAAFAARGVVAANARAANSGPVAEYTLAMI 123
Query: 112 FAVARKIAFADRKMREGVWAKKQAMGIELEG---KTLGIIGFGRIGYQVAKIARALGMNL 168
+++ +R+ R G +T+GI+G +G V + R +++
Sbjct: 124 LLANKRVLAEERRYRASRTLPDHFGAYAGRGNYRQTVGIVGASTVGRAVLGLLRPFDLDV 183
Query: 169 LLYDPYPNEERAKEVGGKFVDLETLLRESDIVTIHVPLLESTYHLINEERLKLMKKSAIL 228
LLYDP E+A +G + V L+ L+ S +V++H PL +T I+ RL LM A L
Sbjct: 184 LLYDPTLTAEQAAALGARLVPLDELMAHSRVVSLHQPLTPATRGQIDAGRLALMPDGATL 243
Query: 229 INTSRGAVVDTNALVKALEEGWIAGAGLDVYEEEPLPKDHPLTKFDNVVLTPHIGASTVE 288
+NT+RGAVVD +AL+ + G I A LDV E EP L DNVVLTPH+ S
Sbjct: 244 VNTARGAVVDQDALLAEVRTGRI-DAVLDVTEPEPPDPGSELWALDNVVLTPHLAGSLGG 302
Query: 289 AQERAGVEVAEKVVKILKG 307
R G VA++V + G
Sbjct: 303 ELHRIGDAVADEVERFATG 321
>gb|AAB17663.1| (U31175) D-specific D-2-hydroxyacid dehydrogenase [Staphylococcus
aureus]
Length = 330
Score = 125 bits (312), Expect = 5e-28
Identities = 87/309 (28%), Positives = 153/309 (49%), Gaps = 23/309 (7%)
Query: 14 EKAIQILKDAGLEVIYEEYPEEDRLVELVKDVEAIIVRSKPKVTRKVIESAPK--LKVIA 71
E A+ K +EV + V+ +KD + + K+ V +K IA
Sbjct: 15 EMALNWGKKNNVEVTTSKELLSSATVDQLKDYDGVTTMQFGKLENDVYPKLESYGIKQIA 74
Query: 72 RAGVGLDNIDVEAAKERGIEVVNAPAASSRSVAELAVALMFAVARKIAFADRKMR--EGV 129
+ G D D++ AK+ I + N P+ S ++AE +V++ + R+ +R+++ +
Sbjct: 75 QRTAGFDMYDLDLAKKHNIVISNVPSYSPETIAEYSVSIALQLVRRFPDIERRVQAHDFT 134
Query: 130 WAKKQAMGIELEGKTLGIIGFGRIGYQVAKIARALGMNLLLYDPYPNEERAKEVGGKFVD 189
W + + M ++ T+ IIG GRIG AKI G + YD YPN++ V
Sbjct: 135 W-QAEIMSKPVKNMTVAIIGTGRIGAATAKIYAGFGATITAYDAYPNKDLDFLTYKDSV- 192
Query: 190 LETLLRESDIVTIHVPLLESTYHLINEERLKLMKKSAILINTSRGAVVDTNALVKALEEG 249
+ ++++DI+++HVP + +YHL ++ +KK AIL+N +RGAV++T L+ A+ +G
Sbjct: 193 -KEAIKDADIISLHVPANKESYHLFDKAMFDHVKKGAILVNAARGAVINTPDLIAAVNDG 251
Query: 250 WIAGAGLDVYEEEP-------LPKD------HPLTKFDNVVLTPHIGASTVEAQE---RA 293
+ GA +D YE E KD L + + +++TPHI + EA +
Sbjct: 252 TLLGAAIDTYENEAAYFTNDWTNKDIDDKTLLELIEHERILVTPHIAFFSDEAVQNLVEG 311
Query: 294 GVEVAEKVV 302
G+ A V+
Sbjct: 312 GLNAALSVI 320
>pir||JC7190 D-2-hydroxy-acid dehydrogenase (EC 1.1.99.6) - human
>gi|5852418|gb|AAD54066.1|AF113251_1 (AF113251) putative
2-hydroxyacid dehydrogenase [Homo sapiens]
Length = 248
Score = 125 bits (310), Expect = 8e-28
Identities = 80/237 (33%), Positives = 118/237 (49%), Gaps = 4/237 (1%)
Query: 75 VGLDNIDVEAAKERGIEVVNAPAASSRSVAELAVALMFAVARKIAFADRKMREGVWAKKQ 134
VG+D++ ++ K+RGI V P +R +A R E W +
Sbjct: 3 VGIDHLALDEIKKRGIRVGYTPDVLTRYHRRTRSLPATYHLPPVAGGHRGSEEWWWTSWK 62
Query: 135 AM---GIELEGKTLGIIGFGRIGYQVAKIARALGMNLLLYDP-YPNEERAKEVGGKFVDL 190
+ G L T+GIIG GRIG +A+ + G+ LY P E A E +FV
Sbjct: 63 PLWLCGYGLTQSTVGIIGLGRIGQAIARRLKPFGVQRFLYTGRQPRPEEAAEFQAEFVST 122
Query: 191 ETLLRESDIVTIHVPLLESTYHLINEERLKLMKKSAILINTSRGAVVDTNALVKALEEGW 250
L +SD + + L +T L N++ + MK++A+ IN SRG VV+ + L +AL G
Sbjct: 123 PELAAQSDFIVVACSLTPATEGLCNKDFFQKMKETAVFINISRGDVVNQDDLYQALASGK 182
Query: 251 IAGAGLDVYEEEPLPKDHPLTKFDNVVLTPHIGASTVEAQERAGVEVAEKVVKILKG 307
IA AGLDV EPLP +HPL N V+ PHIG++T + + A ++ L+G
Sbjct: 183 IAAAGLDVTSPEPLPTNHPLLTLKNCVILPHIGSATHRTRNTMSLLAANNLLAGLRG 239
>gb|AAG19748.1| (AE005060) phosphoglycerate dehydrogenase; SerA2 [Halobacterium sp.
NRC-1]
Length = 234
Score = 118 bits (292), Expect = 1e-25
Identities = 72/228 (31%), Positives = 116/228 (50%), Gaps = 4/228 (1%)
Query: 82 VEAAKERGIEVVNAPAASSRSVAELAVALMFAVARKIAFADRKMREGVWAKKQAMGIELE 141
++ +ERG+ V NA + S+AE + + AR + R+ + + QA EL
Sbjct: 1 MDRLRERGVAVTNAAGIHAPSIAEQVLGSVLTFARNLHEGWRRQQRREYRHYQAH--ELG 58
Query: 142 GKTLGIIGFGRIGYQVAKIARALGMNLL--LYDPYPNEERAKEVGGKFVDLETLLRESDI 199
G T+ ++G G IG+ V + ++ + Y P + +G + L +D
Sbjct: 59 GSTVTVVGLGAIGHAVVDRLQGFDVDTIGVRYTPSKGGPTDEVIGFDDAAVHDALARTDY 118
Query: 200 VTIHVPLLESTYHLINEERLKLMKKSAILINTSRGAVVDTNALVKALEEGWIAGAGLDVY 259
+ + PL ++T LI+ + ++L+N +RG VVDT+ALV A+ I GA LDV
Sbjct: 119 LVLATPLTDTTRGLIDAAAFDTLPPESVLVNVARGGVVDTDALVTAIRRQSIRGAALDVT 178
Query: 260 EEEPLPKDHPLTKFDNVVLTPHIGASTVEAQERAGVEVAEKVVKILKG 307
+ EPLP+DHPL F+NV+LTPH T + R VAE + ++ G
Sbjct: 179 DPEPLPEDHPLWNFENVLLTPHNAGHTPDYWPRLADIVAENLSRLDAG 226
>emb|CAB56144.1| (AL117669) putative dehydrogenase [Streptomyces coelicolor A3(2)]
Length = 189
Score = 114 bits (283), Expect = 1e-24
Identities = 62/168 (36%), Positives = 96/168 (56%), Gaps = 5/168 (2%)
Query: 145 LGIIGFGRIGYQVAKIARALGMNLLLYDPYPNEERAKEVGGKFVDLETLLRESDIVTIHV 204
LG++ FG I VA+ ARA G+ + +DP+ +E + + V + L+ +D + +
Sbjct: 2 LGLLSFGAIARLVAERARAFGVEVWAHDPFVDESEIRAARVRPVSFDDLVEGADHLVVQA 61
Query: 205 PLLESTYHLINEERLKLMKKSAILINTSRGAVVDTNALVKALEEGWIAGAGLDVYEEEPL 264
PL T+H + L+ MK +A+L+NT+RG +V+ AL +AL GWIAGA LD EEEP
Sbjct: 62 PLTPQTHHTFDRATLRRMKPTAVLVNTARGPIVEDAALYEALTGGWIAGAALDDIEEEPA 121
Query: 265 PK-----DHPLTKFDNVVLTPHIGASTVEAQERAGVEVAEKVVKILKG 307
+ ++PL + NVV+TPH + EA AE+ V++L G
Sbjct: 122 KQRDWRPNNPLFELPNVVVTPHAAYYSEEAIGTVRTIAAEEAVRVLTG 169
>pir||D75365 probable 2-hydroxyacid dehydrogenase - Deinococcus radiodurans
(strain R1) >gi|6459468|gb|AAF11256.1|AE002011_7
(AE002011) 2-hydroxyacid dehydrogenase, putative
[Deinococcus radiodurans]
Length = 311
Score = 101 bits (249), Expect = 1e-20
Identities = 77/268 (28%), Positives = 126/268 (46%), Gaps = 17/268 (6%)
Query: 44 DVEAIIVRSKPKVTRKVIESAPKLKVIARAGVGLDNIDVEAAKERGIEVVNAPAASSRSV 103
+ + +++ TR + S P L+ + G+++ V+ +G + NA R+V
Sbjct: 44 EAQGVVLWLANGATRDALLSVPGLQWVLTLTAGIEH--VQGKLPQGAALYNAHRLHDRAV 101
Query: 104 AELAVALMFAVARKI-AFADRKMREGVWAKKQAMGI---ELEGKTLGIIGFGRIGYQVAK 159
A VA M A +R + F D + R G W + L+G+ + + G+G IG V +
Sbjct: 102 AVHVVAGMLAASRGLHRFRDAQQR-GEWVRTSLADTGLSTLDGQKVVLWGYGHIGKIVEE 160
Query: 160 IARALGMNLLLYDPYPNEERAKEVGGKFVDLETLLRESDIVTIHVPLLESTYHLINEERL 219
+ G + + VD L E+D V + +P E T ++N ERL
Sbjct: 161 LLAPFGAQVY--------GLTSKTEPDLVDYR--LAEADWVVLLLPSTERTRGIVNAERL 210
Query: 220 KLMKKSAILINTSRGAVVDTNALVKALEEGWIAGAGLDVYEEEPLPKDHPLTKFDNVVLT 279
+K L N RG ++ T+ L+ AL+ G + GA LDV + EPL HPL +NVV+T
Sbjct: 211 TALKPGVWLSNQGRGDLIVTDDLLAALDSGHLGGAVLDVTDPEPLLAGHPLWDRENVVIT 270
Query: 280 PHIGASTVEAQERAGVEVAEKVVKILKG 307
PHI + T + ER ++ +L+G
Sbjct: 271 PHIASITSDLLERGAAYARSFILDVLQG 298
>gb|AAD41656.1|AF090993_1 (AF090993) D-2-hydroxyacid dehydrogenase [Lactobacillus fermentum]
Length = 167
Score = 82.3 bits (200), Expect = 6e-15
Identities = 60/160 (37%), Positives = 82/160 (50%), Gaps = 16/160 (10%)
Query: 162 RALGMNLLLYDPYPNEERAKEVGGKFVDLETLLRESDIVTIHVPLLESTYHLINEERLKL 221
RAL +L YD P EE V ++V E LLR+SD+V++HV L ++ L+ +
Sbjct: 1 RALNARVLGYDLKPREEMEGIV--EYVSKEELLRQSDVVSLHVDLNPTSEGLLTKAEFDQ 58
Query: 222 MKKSAILINTSRGAVVDTNALVKALEEGWIAGAGLDVYE-EEPL-------------PKD 267
MK A L+N SRG VV+T L+ AL++G +A A LD E E P+ P
Sbjct: 59 MKPGASLVNASRGPVVNTADLINALKDGPLAFAALDTVEGEGPIFNADHRQDGLKGEPLV 118
Query: 268 HPLTKFDNVVLTPHIGASTVEAQERAGVEVAEKVVKILKG 307
L DNV+LTPHI T A + + V+ IL G
Sbjct: 119 EELHAMDNVILTPHIAFFTNIAVQNMVDISLDDVITILNG 158
>emb|CAA71175.1| (Y10086) putative dehydrogenase [Arabidopsis thaliana]
Length = 641
Score = 77.3 bits (187), Expect = 2e-13
Identities = 74/311 (23%), Positives = 136/311 (42%), Gaps = 23/311 (7%)
Query: 13 HEKAIQILKDAGLE------VIYEEYPEEDRLVE-LVKDVEAIIVRSKPKVTRKVIESAP 65
H + ++D LE V EY R+ + ++ A+++ S + R
Sbjct: 27 HVVTLNCIEDCALEQDSLAGVAGVEYVPLSRIADGKIESATAVLLHSLAYLPRAAQRRLR 86
Query: 66 KLKVIARAGVGLDNIDVEAAKERGIEVVNAPAASSRSVAELAVALMFAVARKIAFADRK- 124
++I G +D A + G+ +V+ + + +A+ +AL+ + R+ R
Sbjct: 87 PHQLILCLGSADRAVDSTLAADLGLRLVHVDTSRAEEIADTVMALILGLLRRTHLLSRHA 146
Query: 125 MREGVWA---KKQAMGIE-LEGKTLGIIGFGRIGYQVAKIARALGMNLLLYD-PYPNEER 179
+ W + G+ G LGI+G +A + A M++L +D P +EER
Sbjct: 147 LSASGWLGSLQPLCRGMRRCRGMVLGIVGRSVSARYLASRSLAFKMSVLYFDVPEGDEER 206
Query: 180 AK-----EVGGKFVDLETLLRESDIVTIHVPLLESTYHLINEERLKLMKKSAILINTSRG 234
+ + L LL SD++++H L T ++N E L+ +K A L+NT
Sbjct: 207 IRPSRFPRAARRMDTLNDLLAASDVISLHCALTNDTVQILNAECLQHIKPGAFLVNTGSC 266
Query: 235 AVVDTNALVKALEEGWIAGAGLDVYEEEPLPKDHPLTKFDNVVLTPHIGASTVEAQERAG 294
++D A+ + L +G IAG LD E P + + + NV++ P + + E
Sbjct: 267 QLLDDCAVKQLLIDGTIAGCALD-GAEGPQWMEAWVKEIPNVLILPR----SADYSEEVW 321
Query: 295 VEVAEKVVKIL 305
+E+ EK + IL
Sbjct: 322 MEIREKAISIL 332
>emb|CAA73306.1| (Y12776) dehydrogenase [Arabidopsis thaliana]
Length = 636
Score = 77.3 bits (187), Expect = 2e-13
Identities = 74/311 (23%), Positives = 136/311 (42%), Gaps = 23/311 (7%)
Query: 13 HEKAIQILKDAGLE------VIYEEYPEEDRLVE-LVKDVEAIIVRSKPKVTRKVIESAP 65
H + ++D LE V EY R+ + ++ A+++ S + R
Sbjct: 22 HVVTLNCIEDCALEQDSLAGVAGVEYVPLSRIADGKIESATAVLLHSLAYLPRAAQRRLR 81
Query: 66 KLKVIARAGVGLDNIDVEAAKERGIEVVNAPAASSRSVAELAVALMFAVARKIAFADRK- 124
++I G +D A + G+ +V+ + + +A+ +AL+ + R+ R
Sbjct: 82 PHQLILCLGSADRAVDSTLAADLGLRLVHVDTSRAEEIADTVMALILGLLRRTHLLSRHA 141
Query: 125 MREGVWA---KKQAMGIE-LEGKTLGIIGFGRIGYQVAKIARALGMNLLLYD-PYPNEER 179
+ W + G+ G LGI+G +A + A M++L +D P +EER
Sbjct: 142 LSASGWLGSLQPLCRGMRRCRGMVLGIVGRSVSARYLASRSLAFKMSVLYFDVPEGDEER 201
Query: 180 AK-----EVGGKFVDLETLLRESDIVTIHVPLLESTYHLINEERLKLMKKSAILINTSRG 234
+ + L LL SD++++H L T ++N E L+ +K A L+NT
Sbjct: 202 IRPSRFPRAARRMDTLNDLLAASDVISLHCALTNDTVQILNAECLQHIKPGAFLVNTGSC 261
Query: 235 AVVDTNALVKALEEGWIAGAGLDVYEEEPLPKDHPLTKFDNVVLTPHIGASTVEAQERAG 294
++D A+ + L +G IAG LD E P + + + NV++ P + + E
Sbjct: 262 QLLDDCAVKQLLIDGTIAGCALD-GAEGPQWMEAWVKEMPNVLILPR----SADYSEEVW 316
Query: 295 VEVAEKVVKIL 305
+E+ EK + IL
Sbjct: 317 MEIREKAISIL 327
>emb|CAA73307.1| (Y12776) gene5; most likely [Arabidopsis thaliana]
Length = 627
Score = 77.3 bits (187), Expect = 2e-13
Identities = 74/311 (23%), Positives = 136/311 (42%), Gaps = 23/311 (7%)
Query: 13 HEKAIQILKDAGLE------VIYEEYPEEDRLVE-LVKDVEAIIVRSKPKVTRKVIESAP 65
H + ++D LE V EY R+ + ++ A+++ S + R
Sbjct: 13 HVVTLNCIEDCALEQDSLAGVAGVEYVPLSRIADGKIESATAVLLHSLAYLPRAAQRRLR 72
Query: 66 KLKVIARAGVGLDNIDVEAAKERGIEVVNAPAASSRSVAELAVALMFAVARKIAFADRK- 124
++I G +D A + G+ +V+ + + +A+ +AL+ + R+ R
Sbjct: 73 PHQLILCLGSADRAVDSTLAADLGLRLVHVDTSRAEEIADTVMALILGLLRRTHLLSRHA 132
Query: 125 MREGVWA---KKQAMGIE-LEGKTLGIIGFGRIGYQVAKIARALGMNLLLYD-PYPNEER 179
+ W + G+ G LGI+G +A + A M++L +D P +EER
Sbjct: 133 LSASGWLGSLQPLCRGMRRCRGMVLGIVGRSVSARYLASRSLAFKMSVLYFDVPEGDEER 192
Query: 180 AK-----EVGGKFVDLETLLRESDIVTIHVPLLESTYHLINEERLKLMKKSAILINTSRG 234
+ + L LL SD++++H L T ++N E L+ +K A L+NT
Sbjct: 193 IRPSRFPRAARRMDTLNDLLAASDVISLHCALTNDTVQILNAECLQHIKPGAFLVNTGSC 252
Query: 235 AVVDTNALVKALEEGWIAGAGLDVYEEEPLPKDHPLTKFDNVVLTPHIGASTVEAQERAG 294
++D A+ + L +G IAG LD E P + + + NV++ P + + E
Sbjct: 253 QLLDDCAVKQLLIDGTIAGCALD-GAEGPQWMEAWVKEMPNVLILPR----SADYSEEVW 307
Query: 295 VEVAEKVVKIL 305
+E+ EK + IL
Sbjct: 308 MEIREKAISIL 318
>gb|AAF81310.1|AC061957_6 (AC061957) Contains similarity to a dehydrogenase from Arabidopsis
thaliana gb|Y12776 and contains a D-isomer specific
2-hydroxyacid dehydrogenases PF|00389 and Myb-like DNA
binding PF|00249 domains. ESTs gb|Z48385, gb|Z48386
come from this gene
Length = 1284
Score = 77.3 bits (187), Expect = 2e-13
Identities = 74/311 (23%), Positives = 136/311 (42%), Gaps = 23/311 (7%)
Query: 13 HEKAIQILKDAGLE------VIYEEYPEEDRLVE-LVKDVEAIIVRSKPKVTRKVIESAP 65
H + ++D LE V EY R+ + ++ A+++ S + R
Sbjct: 352 HVVTLNCIEDCALEQDSLAGVAGVEYVPLSRIADGKIESATAVLLHSLAYLPRAAQRRLR 411
Query: 66 KLKVIARAGVGLDNIDVEAAKERGIEVVNAPAASSRSVAELAVALMFAVARKIAFADRK- 124
++I G +D A + G+ +V+ + + +A+ +AL+ + R+ R
Sbjct: 412 PHQLILCLGSADRAVDSTLAADLGLRLVHVDTSRAEEIADTVMALILGLLRRTHLLSRHA 471
Query: 125 MREGVWA---KKQAMGIE-LEGKTLGIIGFGRIGYQVAKIARALGMNLLLYD-PYPNEER 179
+ W + G+ G LGI+G +A + A M++L +D P +EER
Sbjct: 472 LSASGWLGSLQPLCRGMRRCRGMVLGIVGRSVSARYLASRSLAFKMSVLYFDVPEGDEER 531
Query: 180 AK-----EVGGKFVDLETLLRESDIVTIHVPLLESTYHLINEERLKLMKKSAILINTSRG 234
+ + L LL SD++++H L T ++N E L+ +K A L+NT
Sbjct: 532 IRPSRFPRAARRMDTLNDLLAASDVISLHCALTNDTVQILNAECLQHIKPGAFLVNTGSC 591
Query: 235 AVVDTNALVKALEEGWIAGAGLDVYEEEPLPKDHPLTKFDNVVLTPHIGASTVEAQERAG 294
++D A+ + L +G IAG LD E P + + + NV++ P + + E
Sbjct: 592 QLLDDCAVKQLLIDGTIAGCALD-GAEGPQWMEAWVKEMPNVLILPR----SADYSEEVW 646
Query: 295 VEVAEKVVKIL 305
+E+ EK + IL
Sbjct: 647 MEIREKAISIL 657
>sp|P75913|YCDW_ECOLI PUTATIVE 2-HYDROXYACID DEHYDROGENASE IN PHOH-CSGG INTERGENIC REGION
>gi|7466696|pir||F64845 probable 2-hydroxyacid
dehydrogenase ycdW - Escherichia coli
>gi|1787270|gb|AAC74117.1| (AE000205) putative
dehydrogenase [Escherichia coli K12]
Length = 325
Score = 73.4 bits (177), Expect = 3e-12
Identities = 48/167 (28%), Positives = 83/167 (48%), Gaps = 2/167 (1%)
Query: 141 EGKTLGIIGFGRIGYQVAKIARALGMNLLLYDPYPNEERAKEVGGKFVDLETLLRESDIV 200
E T+GI+G G +G +VA+ + L + + +L L + ++
Sbjct: 148 EDFTIGILGAGVLGSKVAQSLQTWRFPLRCWSRTRKSWPGVQSFAGREELSAFLSQCRVL 207
Query: 201 TIHVPLLESTYHLINEERLKLMKKSAILINTSRGAVVDTNALVKALEEGWIAGAGLDVYE 260
+P T +IN++ L+ + A L+N +RG V + L+ AL+ G + GA LDV+
Sbjct: 208 INLLPNTPETVGIINQQLLEKLPDGAYLLNLARGVHVVEDDLLAALDSGKVKGAMLDVFN 267
Query: 261 EEPLPKDHPLTKFDNVVLTPHIGASTVEAQERAGVEVAEKVVKILKG 307
EPLP + PL + V +TPH+ A T A+ A ++ + ++ KG
Sbjct: 268 REPLPPESPLWQHPRVTITPHVAAITRPAE--AVEYISRTIAQLEKG 312
>dbj|BAA35814.1| (D90740) Hypothetical 33.0 kd protein in proB-proA intergenic
region. [Escherichia coli] >gi|4062606|dbj|BAA35823.1|
(D90741) Hypothetical 33.0 kd protein in proB-proA
intergenic region. [Escherichia coli]
Length = 312
Score = 73.4 bits (177), Expect = 3e-12
Identities = 48/167 (28%), Positives = 83/167 (48%), Gaps = 2/167 (1%)
Query: 141 EGKTLGIIGFGRIGYQVAKIARALGMNLLLYDPYPNEERAKEVGGKFVDLETLLRESDIV 200
E T+GI+G G +G +VA+ + L + + +L L + ++
Sbjct: 135 EDFTIGILGAGVLGSKVAQSLQTWRFPLRCWSRTRKSWPGVQSFAGREELSAFLSQCRVL 194
Query: 201 TIHVPLLESTYHLINEERLKLMKKSAILINTSRGAVVDTNALVKALEEGWIAGAGLDVYE 260
+P T +IN++ L+ + A L+N +RG V + L+ AL+ G + GA LDV+
Sbjct: 195 INLLPNTPETVGIINQQLLEKLPDGAYLLNLARGVHVVEDDLLAALDSGKVKGAMLDVFN 254
Query: 261 EEPLPKDHPLTKFDNVVLTPHIGASTVEAQERAGVEVAEKVVKILKG 307
EPLP + PL + V +TPH+ A T A+ A ++ + ++ KG
Sbjct: 255 REPLPPESPLWQHPRVTITPHVAAITRPAE--AVEYISRTIAQLEKG 299
>gi|6321253 Ygl185cp [Saccharomyces cerevisiae]
>gi|1723944|sp|P53100|YGT5_YEAST HYPOTHETICAL 43.0 KD
PROTEIN IN COX4-GTS1 INTERGENIC REGION
>gi|2131615|pir||S61132 hypothetical protein YGL185c -
yeast (Saccharomyces cerevisiae)
>gi|1143562|emb|CAA62789.1| (X91489) putative
D-2-hydroxiacid dehydrogenase [Saccharomyces cerevisiae]
>gi|1322801|emb|CAA96897.1| (Z72707) ORF YGL185c
[Saccharomyces cerevisiae]
Length = 379
Score = 71.8 bits (173), Expect = 9e-12
Identities = 80/293 (27%), Positives = 130/293 (44%), Gaps = 42/293 (14%)
Query: 56 VTRKVIE--SAPK--LKVIARAGVGLDNIDVEAAKERGIEVVNAPAASSRS--------- 102
+TR +IE S P+ LK I G D D++ ++ I + N +
Sbjct: 76 MTRSIIEHKSFPRKNLKCIVLCSRGYDGWDLDTLRKHEIRLYNYQDDENEKLIDDLKLHQ 135
Query: 103 ----VAELAVALMFAVARKIAFADRKMRE--------GVWAKKQ--AMGIEL-------- 140
VA+ A+ + RK ++ + RE A+K A G EL
Sbjct: 136 VGNDVADCALWHILEGFRKFSYYQKLSRETGNTLTARAKAAEKSGFAFGHELGNMFAESP 195
Query: 141 EGKTLGIIGFGRIGYQVA-KIARALGMNLLLYDPYPNEERAKEVGGKFVDL-ETL---LR 195
GK I+G G IG QVA K+ LGM + + ++ KF L ET+ L
Sbjct: 196 RGKKCLILGLGSIGKQVAYKLQYGLGMEIHYCKRSEDCTMSQNESWKFHLLDETIYAKLY 255
Query: 196 ESDIVTIHVPLLESTYHLINEERLKLMKKSAILINTSRGAVVDTNALVKALEEGWIAGAG 255
+ + + +P T HLIN + L+ IL+N RG ++D A+ AL G I G
Sbjct: 256 QFHAIVVTLPGTPQTEHLINRKFLEHCNPGLILVNLGRGKILDLRAVSDALVTGRINHLG 315
Query: 256 LDVYEEEPLPKDHPLTKFDNVV-LTPHIGASTVEAQERAGVEVAEKVVKILKG 307
LDV+ +EP D + D + +TPH+G++T + E++ ++++++ G
Sbjct: 316 LDVFNKEP-EIDEKIRSSDRLTSITPHLGSATKDVFEQSCELALTRILRVVSG 367
Database: ./suso.pep
Posted date: Jul 6, 2001 5:57 PM
Number of letters in database: 840,471
Number of sequences in database: 2977
Database: /banques/blast2/nr.pep
Posted date: Dec 14, 2000 12:46 PM
Number of letters in database: 188,266,275
Number of sequences in database: 595,510
Lambda K H
0.316 0.136 0.367
Gapped
Lambda K H
0.270 0.0470 0.230
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 100816531
Number of Sequences: 2977
Number of extensions: 4043299
Number of successful extensions: 13503
Number of sequences better than 1.0e-10: 208
Number of HSP's better than 0.0 without gapping: 170
Number of HSP's successfully gapped in prelim test: 38
Number of HSP's that attempted gapping in prelim test: 12921
Number of HSP's gapped (non-prelim): 212
length of query: 307
length of database: 189,106,746
effective HSP length: 60
effective length of query: 247
effective length of database: 153,197,526
effective search space: 37839788922
effective search space used: 37839788922
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 41 (21.6 bits)
S2: 165 (68.7 bits)