BLASTP 2.0.10 [Aug-26-1999]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= PAB0570 (panB) DE:3-METHYL-2-OXOBUTANOATE
HYDROXYMETHYLTRANSFERASE (EC 2.1.2.11)
(282 letters)
Database: ./suso.pep; /banques/blast2/nr.pep
598,487 sequences; 189,106,746 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
pir||B75131 3-methyl-2-oxobutanoate hydroxymethyltransferase (EC... 561 e-159
sp|O58665|PANB_PYRHO 3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSF... 519 e-146
sp|Q9X251|PANB_THEMA 3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSF... 293 2e-78
gb|AAK42546.1| Ketopantoate hydroxymethyltransferase (panB) [Sul... 293 2e-78
sp|Q9YE97|PANB_AERPE 3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSF... 286 3e-76
sp|Q9Y7B6|PANB_EMENI 3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSF... 232 4e-60
sp|O67783|PANB_AQUAE 3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSF... 231 9e-60
dbj|BAB05406.1| (AP001512) ketopantoate hydroxymethyltransferase... 227 1e-58
pir||T47945 3-methyl-2-oxobutanoate hydroxy-methyl-transferase-l... 226 3e-58
sp|P52996|PANB_BACSU 3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSF... 226 3e-58
pir||F81448 3-methyl-2-oxobutanoate hydroxymethyltransferase (EC... 224 7e-58
gb|AAC62893.1| (AC005397) 3-methyl-2-oxobutanoate hydroxy-methyl... 223 2e-57
pir||C83447 conserved hypothetical protein PA1598 [imported] - P... 222 3e-57
sp|Q9X712|PANB_CORGL 3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSF... 219 3e-56
sp|P52997|PANB_SYNY3 3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSF... 218 5e-56
pir||E75253 3-methyl-2-oxobutanoate hydroxymethyltransferase - D... 216 2e-55
pir||T50565 3-methyl-2-oxobutanoate hydroxymethyltransferase (EC... 215 6e-55
pir||F81148 3-methyl-2-oxobutanoate hydroxymethyltransferase NMB... 215 6e-55
pir||E81874 probable 3-methyl-2-oxobutanoate hydroxymethyltransf... 213 2e-54
gb|AAG19781.1| (AE005063) ketopantoate hydroxymethyltransferase-... 212 3e-54
sp|O25698|PANB_HELPY 3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSF... 208 8e-53
sp|Q9ZM56|PANB_HELPJ 3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSF... 205 4e-52
pir||F83055 3-methyl-2-oxobutanoate hydroxymethyltransferase PA4... 204 1e-51
pir||T50554 3-methyl-2-oxobutanoate hydroxymethyltransferase (EC... 203 2e-51
pir||A47152 3-methyl-2-oxobutanoate hydroxymethyltransferase (EC... 203 3e-51
sp|Q10505|PANB_MYCTU 3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSF... 203 3e-51
sp|P31057|PANB_ECOLI 3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSF... 199 4e-50
sp|Q9ZEP8|PANB_PSEFL 3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSF... 199 4e-50
sp|Q09672|PANB_SCHPO PROBABLE 3-METHYL-2-OXOBUTANOATE HYDROXYMET... 196 2e-49
pir||E82832 3-methyl-2-oxobutanoate hydroxymethyltransferase XF0... 196 2e-49
pir||A82304 3-methyl-2-oxobutanoate hydroxymethyltransferase VC0... 194 1e-48
sp|P57293|PANB_BUCAI 3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSF... 192 3e-48
pir||T51696 3-methyl-2-oxobutanoate hydroxymethyltransferase (EC... 189 3e-47
gi|6319653 Probable 3-methyl-2-oxobutanoate hydroxymethyltransfe... 177 1e-43
gb|AAA85381.1| (L47126) orf3 gene product [Synechocystis sp.] 131 1e-29
emb|CAB62149.1| (AJ245666) hypothetical protein [Sinorhizobium m... 118 6e-26
>pir||B75131 3-methyl-2-oxobutanoate hydroxymethyltransferase (EC 2.1.2.11)
PAB0570 - Pyrococcus abyssi (strain Orsay)
>gi|5458274|emb|CAB49763.1| (AJ248285)
3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE (EC
2.1.2.11) [Pyrococcus abyssi]
Length = 282
Score = 561 bits (1430), Expect = e-159
Identities = 282/282 (100%), Positives = 282/282 (100%)
Query: 1 MREITPRKIIEMKGKEKIAMITAYDYPSALLADKAGFDIVFVGDSLGMVVYGEPNTLNVS 60
MREITPRKIIEMKGKEKIAMITAYDYPSALLADKAGFDIVFVGDSLGMVVYGEPNTLNVS
Sbjct: 1 MREITPRKIIEMKGKEKIAMITAYDYPSALLADKAGFDIVFVGDSLGMVVYGEPNTLNVS 60
Query: 61 MEQMVFHTRAVARAVKRALVLADMPFGSYEVSVEEGIKNAIKLIQAGADAVKIEGGYDHK 120
MEQMVFHTRAVARAVKRALVLADMPFGSYEVSVEEGIKNAIKLIQAGADAVKIEGGYDHK
Sbjct: 61 MEQMVFHTRAVARAVKRALVLADMPFGSYEVSVEEGIKNAIKLIQAGADAVKIEGGYDHK 120
Query: 121 KLVKRLVRMGIPVMGHTGLTPQRYLRLGGYRIMGSTEEEVEEIIRDAKALEKAGAFAVVL 180
KLVKRLVRMGIPVMGHTGLTPQRYLRLGGYRIMGSTEEEVEEIIRDAKALEKAGAFAVVL
Sbjct: 121 KLVKRLVRMGIPVMGHTGLTPQRYLRLGGYRIMGSTEEEVEEIIRDAKALEKAGAFAVVL 180
Query: 181 EFVLADVAKLVTEEVSIPTIGIGSGPYVDGQVLVWHDVLGLYEESPPFVKRYANLRDEIL 240
EFVLADVAKLVTEEVSIPTIGIGSGPYVDGQVLVWHDVLGLYEESPPFVKRYANLRDEIL
Sbjct: 181 EFVLADVAKLVTEEVSIPTIGIGSGPYVDGQVLVWHDVLGLYEESPPFVKRYANLRDEIL 240
Query: 241 GAISEFKKDVKEGKFPGREHYWEFQDKEEFKRIKESVLRKVD 282
GAISEFKKDVKEGKFPGREHYWEFQDKEEFKRIKESVLRKVD
Sbjct: 241 GAISEFKKDVKEGKFPGREHYWEFQDKEEFKRIKESVLRKVD 282
>sp|O58665|PANB_PYRHO 3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE (KETOPANTOATE
HYDROXYMETHYLTRANSFERASE) >gi|7433450|pir||B71086
probable 3-methyl-2-oxobutanoate
hydroxymethyltransferase - Pyrococcus horikoshii
>gi|3257365|dbj|BAA30048.1| (AP000004) 283aa long
hypothetical 3-methyl-2-oxobutanoate
hydroxymethyltransferase [Pyrococcus horikoshii]
Length = 283
Score = 519 bits (1322), Expect = e-146
Identities = 251/282 (89%), Positives = 275/282 (97%)
Query: 1 MREITPRKIIEMKGKEKIAMITAYDYPSALLADKAGFDIVFVGDSLGMVVYGEPNTLNVS 60
MREITP++I EMKGKEKI MITAYDYPSALLADKAGFDIVF+GDSLGMVVYGEP+TLNV+
Sbjct: 1 MREITPKRIREMKGKEKITMITAYDYPSALLADKAGFDIVFIGDSLGMVVYGEPSTLNVT 60
Query: 61 MEQMVFHTRAVARAVKRALVLADMPFGSYEVSVEEGIKNAIKLIQAGADAVKIEGGYDHK 120
MEQM+FHTRAVA+AVKRALVLADMPFGSYEVSVEEGIKNAIKL+QAGADAVKIEGGYDH+
Sbjct: 61 MEQMIFHTRAVAKAVKRALVLADMPFGSYEVSVEEGIKNAIKLVQAGADAVKIEGGYDHR 120
Query: 121 KLVKRLVRMGIPVMGHTGLTPQRYLRLGGYRIMGSTEEEVEEIIRDAKALEKAGAFAVVL 180
KLVK+LVR+GIPVMGHTGLTPQRYLRLGGYRIMG TEEEVEEI+RDAKALEKAGAFA+VL
Sbjct: 121 KLVKKLVRIGIPVMGHTGLTPQRYLRLGGYRIMGGTEEEVEEILRDAKALEKAGAFAIVL 180
Query: 181 EFVLADVAKLVTEEVSIPTIGIGSGPYVDGQVLVWHDVLGLYEESPPFVKRYANLRDEIL 240
EFVLADVAKLVTEEVSIPTIGIGSGPYVDGQVLVWHDVLGLYE SPPF KRYANL++EIL
Sbjct: 181 EFVLADVAKLVTEEVSIPTIGIGSGPYVDGQVLVWHDVLGLYESSPPFAKRYANLKEEIL 240
Query: 241 GAISEFKKDVKEGKFPGREHYWEFQDKEEFKRIKESVLRKVD 282
AIS F+++VKEGKFPGREHYWEFQDKEEFKRIK++V++K++
Sbjct: 241 RAISTFREEVKEGKFPGREHYWEFQDKEEFKRIKDNVMKKLN 282
>sp|Q9X251|PANB_THEMA 3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE (KETOPANTOATE
HYDROXYMETHYLTRANSFERASE) >gi|7433451|pir||G72216
3-methyl-2-oxobutanoate hydroxymethyltransferase -
Thermotoga maritima (strain MSB8)
>gi|4982305|gb|AAD36793.1|AE001812_3 (AE001812)
3-methyl-2-oxobutanoate hydroxymethyltransferase
[Thermotoga maritima]
Length = 270
Score = 293 bits (742), Expect = 2e-78
Identities = 149/263 (56%), Positives = 193/263 (72%), Gaps = 3/263 (1%)
Query: 8 KIIEMKGKEKIAMITAYDYPSALLADKAGFDIVFVGDSLGMVVYGEPNTLNVSMEQMVFH 67
K+ +MKGKEKI M+TAYD PSA +A AG D++ VGDSLG V G NT+ V+ME+M+ H
Sbjct: 5 KLKKMKGKEKIVMVTAYDAPSARIARDAGIDVILVGDSLGNNVLGYENTIPVTMEEMLIH 64
Query: 68 TRAVARAVKRALVLADMPFGSYEVSVEEGIKNAIKLIQAGADAVKIEGGYDHKKLVKRLV 127
AV R A ++ADMPF SY+ SVE+ ++NA K ++ GA+AVKIEGG + +LV++LV
Sbjct: 65 VAAVKRGAPDAFIVADMPFLSYQTSVEKAVENAGKFLKVGANAVKIEGGEEFGELVQKLV 124
Query: 128 RMGIPVMGHTGLTPQRYLRLGGYRIMGSTEEEVEEIIRDAKALEKAGAFAVVLEFVLADV 187
GIPVMGH GLTPQ R GGYR+ G TE+ E ++R A+ LEK GAFA+VLE V+ +V
Sbjct: 125 ESGIPVMGHIGLTPQFVNRFGGYRVQGKTEKNREYLLRSARELEKRGAFAIVLELVVEEV 184
Query: 188 AKLVTEEVSIPTIGIGSGPYVDGQVLVWHDVLGLYEE-SPPFVKRYANLRDEILGAISEF 246
AK +TE VSIPTIGIGSG + DGQVLVWHD+LGL + +P F K+YANL + IL A+ EF
Sbjct: 185 AKEITESVSIPTIGIGSGRFCDGQVLVWHDLLGLNPDFAPRFSKKYANLYEVILKALQEF 244
Query: 247 KKDVKEGKFPGREHYWEFQDKEE 269
+++VK+G FP EH F DK +
Sbjct: 245 RREVKKGLFPTEEH--SFTDKSK 265
>gb|AAK42546.1| Ketopantoate hydroxymethyltransferase (panB) [Sulfolobus
solfataricus]
Length = 267
Score = 293 bits (741), Expect = 2e-78
Identities = 142/264 (53%), Positives = 196/264 (73%), Gaps = 1/264 (0%)
Query: 1 MREITPRKIIEMKG-KEKIAMITAYDYPSALLADKAGFDIVFVGDSLGMVVYGEPNTLNV 59
M+++T R I+ K KEKI M+TAYDYP+A + D + VGDSLGMVV G NTLNV
Sbjct: 1 MKKVTIRDFIKKKSMKEKITMLTAYDYPTAKIISNTTLDSILVGDSLGMVVLGYTNTLNV 60
Query: 60 SMEQMVFHTRAVARAVKRALVLADMPFGSYEVSVEEGIKNAIKLIQAGADAVKIEGGYDH 119
+M M+ HTRAVARA L+++DMPF SYE+ V+ +KNA L++AG+DAVK+EGG +
Sbjct: 61 TMRDMISHTRAVARANPPQLIVSDMPFLSYEIDVKSAVKNAGLLVKAGSDAVKLEGGEEI 120
Query: 120 KKLVKRLVRMGIPVMGHTGLTPQRYLRLGGYRIMGSTEEEVEEIIRDAKALEKAGAFAVV 179
K +++ +V+ GIPVMGH GLTPQR+LRLGG+R +G T++E E++I+D+ LE AG F++V
Sbjct: 121 KDIIRAIVKAGIPVMGHIGLTPQRFLRLGGFRTIGKTKQEEEQLIKDSLELEDAGVFSIV 180
Query: 180 LEFVLADVAKLVTEEVSIPTIGIGSGPYVDGQVLVWHDVLGLYEESPPFVKRYANLRDEI 239
+E D+AK +TE++++PTI IG+GPY DGQVLV HD+LGL E +P F K Y NL++ I
Sbjct: 181 IENTYVDIAKRITEKLNVPTICIGAGPYCDGQVLVIHDLLGLSEVTPYFAKSYVNLKEII 240
Query: 240 LGAISEFKKDVKEGKFPGREHYWE 263
AI+++ DVK KFP ++HY E
Sbjct: 241 SSAINQYIIDVKTNKFPEKQHYKE 264
>sp|Q9YE97|PANB_AERPE 3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE (KETOPANTOATE
HYDROXYMETHYLTRANSFERASE) >gi|7433449|pir||A72656
probable 3-methyl-2-oxobutanoate hydroxymethyl
transferase APE0676 - Aeropyrum pernix (strain K1)
>gi|5104334|dbj|BAA79649.1| (AP000060) 274aa long
hypothetical 3-methyl-2-oxobutanoate hydroxymethyl
transferase [Aeropyrum pernix]
Length = 274
Score = 286 bits (723), Expect = 3e-76
Identities = 132/258 (51%), Positives = 189/258 (73%)
Query: 3 EITPRKIIEMKGKEKIAMITAYDYPSALLADKAGFDIVFVGDSLGMVVYGEPNTLNVSME 62
++T R+I++MKG I +TAYDYP+A +AD+AG D++ VGDSLGMVV G P+TL V+++
Sbjct: 5 KVTARRILKMKGSRPIVAVTAYDYPTAWIADEAGVDVILVGDSLGMVVLGYPSTLQVTLD 64
Query: 63 QMVFHTRAVARAVKRALVLADMPFGSYEVSVEEGIKNAIKLIQAGADAVKIEGGYDHKKL 122
MV HT AVARA KR L++ADMPFGSYE S +++A+ L + GA+AVK+EGG ++
Sbjct: 65 DMVRHTAAVARAAKRPLIVADMPFGSYEPSSSAAVESAVALARVGAEAVKLEGGSEYADR 124
Query: 123 VKRLVRMGIPVMGHTGLTPQRYLRLGGYRIMGSTEEEVEEIIRDAKALEKAGAFAVVLEF 182
VK +V GIPVMGH GLTPQR +R+GGYR +E ++ DA++L +AG F++VLEF
Sbjct: 125 VKAIVDAGIPVMGHLGLTPQRAMRIGGYRPRARGRDEARRLLLDAESLVEAGVFSIVLEF 184
Query: 183 VLADVAKLVTEEVSIPTIGIGSGPYVDGQVLVWHDVLGLYEESPPFVKRYANLRDEILGA 242
V + A++VT V +PTI IGSG DGQ++V+HD++GL +PPF K+Y + R ++ A
Sbjct: 185 VSEEAAEMVTRRVPVPTICIGSGRRCDGQIIVFHDIVGLSRHTPPFAKKYVDARRIMVEA 244
Query: 243 ISEFKKDVKEGKFPGREH 260
++ + +DV+ G+FPG EH
Sbjct: 245 VTRYAEDVRNGRFPGEEH 262
>sp|Q9Y7B6|PANB_EMENI 3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE (KETOPANTOATE
HYDROXYMETHYLTRANSFERASE) >gi|11359354|pir||T50553
3-methyl-2-oxobutanoate hydroxymethyltransferase (EC
2.1.2.11) [imported] - Emericella nidulans
>gi|5001995|gb|AAD37248.1|AF134703_1 (AF134703)
ketopantoate hydroxymethyltransferase [Aspergillus
nidulans]
Length = 349
Score = 232 bits (585), Expect = 4e-60
Identities = 119/286 (41%), Positives = 187/286 (64%), Gaps = 12/286 (4%)
Query: 3 EITPRKIIEM-------KGKEKIAMITAYDYPSALLADKAGFDIVFVGDSLGMVVYGEPN 55
+ PRK + M K E I M+TA+D+PSA +AD AG D++ VGDSL MV G +
Sbjct: 58 QANPRKKVTMQTLRNLYKKGEPITMLTAHDFPSAHVADAAGMDMILVGDSLAMVALGMQD 117
Query: 56 TLNVSMEQMVFHTRAVARAVKRALVLADMPFGSYEVSVEEGIKNAIKLIQAG-ADAVKIE 114
T V+++ M+ H R+VARA + A ++D+P GSYEVS E+ +++AI++++ G VK+E
Sbjct: 118 TSEVTLDDMLVHCRSVARAAQSAFTVSDLPMGSYEVSPEQALQSAIRIVKEGRVQGVKLE 177
Query: 115 GGYDHKKLVKRLVRMGIPVMGHTGLTPQRYLRLGGYRIMGSTEEEVEEIIRDAKALEKAG 174
GG + +KR+ GIPV+GH GLTPQR LGG+R+ G + + ++++DA A+++AG
Sbjct: 178 GGEEMAPAIKRITTAGIPVVGHIGLTPQRQNALGGFRVQGKSTTDALKLLKDALAVQEAG 237
Query: 175 AFAVVLEFVLADVAKLVTEEVSIPTIGIGSGPYVDGQVLVWHDVLGLYEES---PPFVKR 231
AF +V+E V ++A +VT+++S+PTIGIG+G GQVLV D+ G + P FVK+
Sbjct: 238 AFMIVIEAVPPEIASIVTQKLSVPTIGIGAGNGCSGQVLVQIDMTGNFPPGRFLPKFVKQ 297
Query: 232 YANLRDEILGAISEFKKDVKEGKFPGREHYWEFQDKEEFKRIKESV 277
YAN+ +E L I +++++VK +P +H + KEE +++V
Sbjct: 298 YANVWNEALQGIQQYREEVKSRAYPAEQHTYPI-PKEELVEFQKAV 342
>sp|O67783|PANB_AQUAE 3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE (KETOPANTOATE
HYDROXYMETHYLTRANSFERASE) >gi|7433447|pir||C70469
3-methyl-2-oxobutanoate hydroxymethyltransferase -
Aquifex aeolicus >gi|2984220|gb|AAC07749.1| (AE000766)
3-methyl-2-oxobutanoate hydroxymethyltransferase
[Aquifex aeolicus]
Length = 265
Score = 231 bits (582), Expect = 9e-60
Identities = 119/246 (48%), Positives = 171/246 (69%), Gaps = 2/246 (0%)
Query: 16 EKIAMITAYDYPSALLADKAGFDIVFVGDSLGMVVYGEPNTLNVSMEQMVFHTRAVARAV 75
+KI M++ YDY SA L D+ G D + VGDSLG VV GE +TL+V++E++++HT+ V R V
Sbjct: 16 KKITMVSTYDYWSAKLCDEVGIDCILVGDSLGTVVKGEGDTLSVTLEEIIYHTKCVMRGV 75
Query: 76 KRALVLADMPFGSYEVSVEEGIKNAIKLI-QAGADAVKIEGGYDHKKLVKRLVRMGIPVM 134
K A V+ADMPF SY+VS+E+ ++N ++I + A AVK+EGG + +LV +L R+GIPV+
Sbjct: 76 KNAFVIADMPFMSYQVSMEKAVENCGRVIKETKAKAVKLEGGEEIAELVYKLTRIGIPVV 135
Query: 135 GHTGLTPQRYLRLGGYRIMGSTEEEVEEIIRDAKALEKAGAFAVVLEFVLADVAKLVTEE 194
GH G TPQ G +++G +EE E++ RD +ALE+AGAF +VLE V +AK + +
Sbjct: 136 GHVGFTPQHINVFGKPKVVGKKKEEEEKLRRDFRALEEAGAFMIVLESVPTHLAKELWKG 195
Query: 195 VSIPTIGIGSGPYVDGQVLVWHDVLGLYEE-SPPFVKRYANLRDEILGAISEFKKDVKEG 253
+ IGIG+G YVDGQVLV+HD++GL+E+ P FV+RY + A+ FK DV+ G
Sbjct: 196 SNSIVIGIGAGKYVDGQVLVFHDIVGLFEDFKPKFVRRYLEGAKLVKEALKNFKIDVEGG 255
Query: 254 KFPGRE 259
FP E
Sbjct: 256 NFPSEE 261
>dbj|BAB05406.1| (AP001512) ketopantoate hydroxymethyltransferase [Bacillus
halodurans]
Length = 279
Score = 227 bits (572), Expect = 1e-58
Identities = 116/254 (45%), Positives = 168/254 (65%), Gaps = 2/254 (0%)
Query: 15 KEKIAMITAYDYPSALLADKAGFDIVFVGDSLGMVVYGEPNTLNVSMEQMVFHTRAVARA 74
KEKIAM+TAYD PSA L + A D++ VGDSLGMVV G +T+ V+++ M+ HT+AV R
Sbjct: 14 KEKIAMMTAYDAPSARLVEDADVDMILVGDSLGMVVLGYDSTIPVTLDDMIHHTKAVKRG 73
Query: 75 VKRALVLADMPFGSYEVSVEEGIKNAIKLIQ-AGADAVKIEGGYDHKKLVKRLVRMGIPV 133
K ++ DMP+ +Y S E + A +L+Q AGADA+K+EG D ++RL G+P+
Sbjct: 74 AKNTFIVTDMPYLTYHGSFNETLVGAKRLMQEAGADALKLEGNGDIIDTIERLTLAGVPI 133
Query: 134 MGHTGLTPQRYLRLGGYRIMGSTEEEVEEIIRDAKALEKAGAFAVVLEFVLADVAKLVTE 193
+ H GLTPQ GGYR+ + ++++ DAKA+E AGAFA+VLE V VA ++E
Sbjct: 134 VAHLGLTPQNVAVEGGYRVQAKDAKSAKQLLADAKAVEAAGAFALVLECVPEQVATQISE 193
Query: 194 EVSIPTIGIGSGPYVDGQVLVWHDVLGL-YEESPPFVKRYANLRDEILGAISEFKKDVKE 252
E++IP IGIG+G DGQVLV+HDV+G P FVK+Y N+ I A+ ++ ++VK
Sbjct: 194 ELTIPVIGIGAGAGCDGQVLVYHDVIGYGAGHVPSFVKQYVNITKPIEEAMKQYVQEVKA 253
Query: 253 GKFPGREHYWEFQD 266
G FP ++H + ++
Sbjct: 254 GTFPDKDHAFSLKE 267
>pir||T47945 3-methyl-2-oxobutanoate hydroxy-methyl-transferase-like protein -
Arabidopsis thaliana >gi|6850844|emb|CAB71083.1|
(AL132962) 3-methyl-2-oxobutanoate
hydroxy-methyl-transferase-like protein [Arabidopsis
thaliana]
Length = 354
Score = 226 bits (569), Expect = 3e-58
Identities = 116/253 (45%), Positives = 163/253 (63%), Gaps = 8/253 (3%)
Query: 16 EKIAMITAYDYPSALLADKAGFDIVFVGDSLGMVVYGEPNTLNVSMEQMVFHTRAVARAV 75
E I M+TAYDYPSA+ D AG D+ VGDS MVV+G TL +S+E+M+ H RAVAR
Sbjct: 57 EPITMVTAYDYPSAVHIDTAGIDVCLVGDSAAMVVHGYDTTLPISLEEMLVHCRAVARGA 116
Query: 76 KRALVLADMPFGSYEVSVEEGIKNAIKLI-QAGADAVKIEGGYDHK-KLVKRLVRMGIPV 133
KR L++ D+PFG+YE S + + A++++ + G DA+K+EGG + K +V GI V
Sbjct: 117 KRPLLVGDLPFGTYESSTNQAVDTAVRVLKEGGMDAIKLEGGSPSRITAAKSIVEAGIAV 176
Query: 134 MGHTGLTPQRYLRLGGYRIMGSTEEEVEEIIRDAKALEKAGAFAVVLEFVLADVAKLVTE 193
MGH GLTPQ LGG+R G +++ A AL++AG F+VVLE V VA T
Sbjct: 177 MGHVGLTPQAISVLGGFRPQGKNIASAVKVVETAMALQEAGCFSVVLECVPPPVAAAATS 236
Query: 194 EVSIPTIGIGSGPYVDGQVLVWHDVLGLYEE------SPPFVKRYANLRDEILGAISEFK 247
++IPTIGIG+GP+ GQVLV+HD+LG+ + +P F K+YA + + I A+ E+K
Sbjct: 237 ALNIPTIGIGAGPFCSGQVLVYHDLLGMMQHPHHAKVTPKFCKQYAQVGEVINKALLEYK 296
Query: 248 KDVKEGKFPGREH 260
++V + FPG H
Sbjct: 297 EEVSKHLFPGPSH 309
>sp|P52996|PANB_BACSU 3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE (KETOPANTOATE
HYDROXYMETHYLTRANSFERASE) >gi|7433446|pir||G69671
ketopantoate hydroxymethyltransferase panB - Bacillus
subtilis >gi|1146240|gb|AAB38448.1| (L47709)
ketopantoate hydroxymethyltransferase [Bacillus
subtilis] >gi|2634661|emb|CAB14159.1| (Z99115)
ketopantoate hydroxymethyltransferase [Bacillus
subtilis]
Length = 277
Score = 226 bits (569), Expect = 3e-58
Identities = 117/262 (44%), Positives = 174/262 (65%), Gaps = 3/262 (1%)
Query: 5 TPRKIIEMK-GKEKIAMITAYDYPSALLADKAGFDIVFVGDSLGMVVYGEPNTLNVSMEQ 63
T ++MK +E I M+TAYDYP+A LA++AG D++ VGDSLGMVV G +T+ V++
Sbjct: 3 TKLDFLKMKESEEPIVMLTAYDYPAAKLAEQAGVDMILVGDSLGMVVLGLDSTVGVTVAD 62
Query: 64 MVFHTRAVARAVKRALVLADMPFGSYEVSVEEGIKNAIKLIQ-AGADAVKIEGGYDHKKL 122
M+ HT+AV R ++ DMPF SY +S E+ +KNA ++Q +GADA+K+EGG +
Sbjct: 63 MIHHTKAVKRGAPNTFIVTDMPFMSYHLSKEDTLKNAAAIVQESGADALKLEGGEGVFES 122
Query: 123 VKRLVRMGIPVMGHTGLTPQRYLRLGGYRIMGSTEEEVEEIIRDAKALEKAGAFAVVLEF 182
++ L GIPV+ H GLTPQ LGGY++ G E+ +++I D+ E+AGA +VLE
Sbjct: 123 IRALTLGGIPVVSHLGLTPQSVGVLGGYKVQGKDEQSAKKLIEDSIKCEEAGAMMLVLEC 182
Query: 183 VLADVAKLVTEEVSIPTIGIGSGPYVDGQVLVWHDVLGL-YEESPPFVKRYANLRDEILG 241
V A++ + E +SIP IGIG+G DGQVLV+HD++G E +P FVK+Y + + I
Sbjct: 183 VPAELTAKIAETLSIPVIGIGAGVKADGQVLVYHDIIGHGVERTPKFVKQYTRIDETIET 242
Query: 242 AISEFKKDVKEGKFPGREHYWE 263
AIS + +DV+ FP ++H ++
Sbjct: 243 AISGYVQDVRHRAFPEQKHSFQ 264
>pir||F81448 3-methyl-2-oxobutanoate hydroxymethyltransferase (EC 2.1.2.11)
Cj0298c [imported] - Campylobacter jejuni (strain NCTC
11168) >gi|6967772|emb|CAB72765.1| (AL139074)
3-methyl-2-oxobutanoate hydroxymethyltransferase
[Campylobacter jejuni]
Length = 274
Score = 224 bits (566), Expect = 7e-58
Identities = 118/262 (45%), Positives = 175/262 (66%), Gaps = 5/262 (1%)
Query: 10 IEMKGK-EKIAMITAYDYPSALLADKAGFDIVFVGDSLGMVVYGEPNTLNVSMEQMVFHT 68
+E K K EKI M++AYDY SA + D + DI+ VGDSL M V G +TL+V+M++M+ T
Sbjct: 9 LEKKAKNEKITMVSAYDYHSARILDNSDIDIILVGDSLAMTVLGMQDTLSVTMDEMLIFT 68
Query: 69 RAVARAVKRALVLADMPFGSYEVSVEEGIKNAIKLI-QAGADAVKIEGGYDHKKLVKRLV 127
+AV+R K++ VLADMPF SY+ S + I NA + I ++ A+ VK+EGG + +K +
Sbjct: 69 KAVSRGAKKSFVLADMPFMSYQSSDRDAILNASRFIKESHANGVKVEGGIEIASKIKLIS 128
Query: 128 RMGIPVMGHTGLTPQRYLRLGGYRIMGSTEEEVEEIIRDAKALEKAGAFAVVLEFVLADV 187
+ GIPV+ H GLTPQ LGGYR+ G + ++II DAKA++ AGA +VLE V +
Sbjct: 129 QSGIPVVAHLGLTPQAVNMLGGYRVQGKDLQSAQKIIDDAKAVQDAGACMLVLECVPVKL 188
Query: 188 AKLVTEEVSIPTIGIGSGPYVDGQVLVWHDVLGLYEE-SPPFVKRYANLRDEILGAISEF 246
A+ ++ + IPTIGIGSG Y DGQVLV+HD+LGL ++ FVK + + ++ + ++
Sbjct: 189 AQKISSILEIPTIGIGSGKYCDGQVLVYHDLLGLNKDFKAKFVKHFDKIDPQV--GVEKY 246
Query: 247 KKDVKEGKFPGREHYWEFQDKE 268
+ +VK G FP +EH +++ D E
Sbjct: 247 RDEVKSGIFPSQEHSFDYLDDE 268
>gb|AAC62893.1| (AC005397) 3-methyl-2-oxobutanoate hydroxy-methyl-transferase
[Arabidopsis thaliana]
Length = 347
Score = 223 bits (562), Expect = 2e-57
Identities = 114/253 (45%), Positives = 163/253 (64%), Gaps = 8/253 (3%)
Query: 16 EKIAMITAYDYPSALLADKAGFDIVFVGDSLGMVVYGEPNTLNVSMEQMVFHTRAVARAV 75
E I ++TAYDYPSA+ D AG D+ VGDS MVV+G TL +S+++M+ H RAVAR
Sbjct: 55 EPITVVTAYDYPSAVHLDTAGIDVCLVGDSASMVVHGHDTTLPISLDEMLVHCRAVARGA 114
Query: 76 KRALVLADMPFGSYEVSVEEGIKNAIKLI-QAGADAVKIEGGYDHK-KLVKRLVRMGIPV 133
KR L++ D+PFG+YE S + + A++++ + G DA+K+EGG + K +V GI V
Sbjct: 115 KRPLLVGDLPFGTYESSSSQAVDTAVRVLKEGGMDAIKLEGGSASRITAAKAIVEAGIAV 174
Query: 134 MGHTGLTPQRYLRLGGYRIMGSTEEEVEEIIRDAKALEKAGAFAVVLEFVLADVAKLVTE 193
+GH GLTPQ LGG+R G +++ A AL++AG F+VVLE V VA T
Sbjct: 175 IGHVGLTPQAISVLGGFRPQGRNIASAVKVVETAMALQEAGCFSVVLECVPPPVAAAATS 234
Query: 194 EVSIPTIGIGSGPYVDGQVLVWHDVLGLYEE------SPPFVKRYANLRDEILGAISEFK 247
+ IPTIGIG+GP+ GQVLV+HD+LG+ + +P F K+YAN+ + I A+ E+K
Sbjct: 235 ALKIPTIGIGAGPFCSGQVLVYHDLLGMMQHPHHAKVTPKFCKQYANVGEVINKALMEYK 294
Query: 248 KDVKEGKFPGREH 260
++V + FPG H
Sbjct: 295 EEVSKKVFPGPSH 307
>pir||C83447 conserved hypothetical protein PA1598 [imported] - Pseudomonas
aeruginosa (strain PAO1)
>gi|9947562|gb|AAG04987.1|AE004587_11 (AE004587)
conserved hypothetical protein [Pseudomonas aeruginosa]
Length = 273
Score = 222 bits (561), Expect = 3e-57
Identities = 121/256 (47%), Positives = 167/256 (64%), Gaps = 3/256 (1%)
Query: 13 KGKEKIAMITAYDYPSALLADKAGFDIVFVGDSLGMVVYGEPNTLNVSMEQMVFHTRAVA 72
KG + +TAY P A L D D++ VGDSLGMV+YG P+TL VS+E MV HT AV
Sbjct: 19 KGAGSLVALTAYSTPMARLLDPHA-DLLLVGDSLGMVLYGMPSTLGVSLEMMVAHTLAVM 77
Query: 73 RAVKRALVLADMPFGSYEVSVEEGIKNAIKLI-QAGADAVKIEGGYDHKKLVKRLVRMGI 131
R +RA V+AD+PF SY+ S + +NA +L+ +GA AVK+EGG + ++ V LVR GI
Sbjct: 78 RGSRRACVVADLPFASYQESPRQAFRNAARLLADSGAQAVKLEGGEEMEETVDFLVRRGI 137
Query: 132 PVMGHTGLTPQRYLRLGGYRIMGSTEEEVEEIIRDAKALEKAGAFAVVLEFVLADVAKLV 191
PV+ H GL PQ+ +GG++ G E E + RD A+++ GAFAVV+E V +A+ +
Sbjct: 138 PVLAHIGLMPQQVNAMGGFKAQGRDPESAERVRRDGLAMQRGGAFAVVIEGVGEPLARRL 197
Query: 192 TEEVSIPTIGIGSGPYVDGQVLVWHDVLGLY-EESPPFVKRYANLRDEILGAISEFKKDV 250
+EE++IP IGIG+ P DGQVLV D+LGL E+ P FV+RYA L EI A F +DV
Sbjct: 198 SEELAIPCIGIGASPACDGQVLVSEDLLGLSGEQVPRFVERYARLDREIDEAARRFAEDV 257
Query: 251 KEGKFPGREHYWEFQD 266
+E +FP H + ++
Sbjct: 258 RERRFPEARHCFAMRE 273
>sp|Q9X712|PANB_CORGL 3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE (KETOPANTOATE
HYDROXYMETHYLTRANSFERASE) >gi|11256690|pir||T47119
3-methyl-2-oxobutanoate hydroxymethyltransferase (EC
2.1.2.11) [validated] - Corynebacterium glutamicum
>gi|4803658|emb|CAA65397.1| (X96580)
3-methyl-2-oxobutanoate hydroxymethyltransferase
[Corynebacterium glutamicum]
Length = 271
Score = 219 bits (552), Expect = 3e-56
Identities = 119/259 (45%), Positives = 172/259 (65%), Gaps = 4/259 (1%)
Query: 2 REITPRKIIEMK-GKEKIAMITAYDYPSALLADKAGFDIVFVGDSLGMVVYGEPNTLNVS 60
++I R E K +K++++T+YD SA + D+AG D++ VGDS VV G TL+++
Sbjct: 9 KKIRTRHFREAKVNGQKVSVLTSYDALSARIFDEAGVDMLLVGDSAANVVLGRDTTLSIT 68
Query: 61 MEQMVFHTRAVARAVKRALVLADMPFGSYEVSVEEGIKNAIKLI-QAGADAVKIEGGYDH 119
+++M+ +AV A KRALV+ D+PFG+YEVS + +++AI+++ + GA AVKIEGG +
Sbjct: 69 LDEMIVLAKAVTIATKRALVVVDLPFGTYEVSPNQAVESAIRVMRETGAAAVKIEGGVEI 128
Query: 120 KKLVKRLVRMGIPVMGHTGLTPQRYLRLGGYRIMGSTEEEVEEIIRDAKALEKAGAFAVV 179
+ ++R+V GIPV+GH G TPQ LGG+ + G ++I DA+ALE+AGAFAVV
Sbjct: 129 AQTIRRIVDAGIPVVGHIGYTPQSEHSLGGHVVQGRGASS-GKLIADARALEQAGAFAVV 187
Query: 180 LEFVLADVAKLVTEEVSIPTIGIGSGPYVDGQVLVWHDVLGLYE-ESPPFVKRYANLRDE 238
LE V A+ A+ VTE++SI TIGIG+G DGQVLVW D GL + P FV+ YA L D
Sbjct: 188 LEMVPAEAAREVTEDLSITTIGIGAGNGTDGQVLVWQDAFGLNRGKKPRFVREYATLGDS 247
Query: 239 ILGAISEFKKDVKEGKFPG 257
+ A + D+ G FPG
Sbjct: 248 LHDAAQAYIADIHAGTFPG 266
>sp|P52997|PANB_SYNY3 3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE (KETOPANTOATE
HYDROXYMETHYLTRANSFERASE) >gi|7433443|pir||S75966
3-methyl-2-oxobutanoate hydroxymethyltransferase (EC
2.1.2.11) - Synechocystis sp. (strain PCC 6803)
>gi|1001326|dbj|BAA10813.1| (D64006) alpha-ketopantoate
hydroxymethyl transferase [Synechocystis sp.]
Length = 260
Score = 218 bits (550), Expect = 5e-56
Identities = 119/258 (46%), Positives = 170/258 (65%), Gaps = 4/258 (1%)
Query: 4 ITPRKIIEMKGKEK-IAMITAYDYPSALLADKAGFDIVFVGDSLGMVVYGEPNTLNVSME 62
ITP ++++ K +++ I +TA+D A + D AG +I+ VGDSLGMV G TL VS++
Sbjct: 3 ITPTQLLDWKRQQRPIVALTAWDTAIASVLDAAGVEIILVGDSLGMVALGYETTLPVSLD 62
Query: 63 QMVFHTRAVARAVKRALVLADMPFGSYEVSVEEGIKNAIKLIQ-AGADAVKIEGGYDHK- 120
M+ HT AV R V+RALV+ D+PF +Y+ S + + +A +++Q GA AVK+EGG+
Sbjct: 63 TMIHHTAAVKRGVQRALVVCDLPFLTYQESPAQAMGSAGRVLQETGAQAVKLEGGHPRMV 122
Query: 121 KLVKRLVRMGIPVMGHTGLTPQRYLRLGGYRIMGSTEEEVEEIIRDAKALEKAGAFAVVL 180
+ V RL +GIPVMGH GLTPQ +LG YR G E+I+ A AL +AG FA+VL
Sbjct: 123 ETVARLTEVGIPVMGHVGLTPQSVHQLG-YRQQGQDPATAEKILHQAIALAEAGVFAIVL 181
Query: 181 EFVLADVAKLVTEEVSIPTIGIGSGPYVDGQVLVWHDVLGLYEESPPFVKRYANLRDEIL 240
E + +++A +TE++ IPTIGIG+GP DGQVLV D+LGL + PPF Y NLR I
Sbjct: 182 EHIPSELAASITEQLPIPTIGIGAGPQCDGQVLVTADLLGLTVKQPPFAPAYLNLRHTIT 241
Query: 241 GAISEFKKDVKEGKFPGR 258
+ +F +V++ +FP R
Sbjct: 242 ETVHKFSGEVRQRQFPRR 259
>pir||E75253 3-methyl-2-oxobutanoate hydroxymethyltransferase - Deinococcus
radiodurans (strain R1)
>gi|6460442|gb|AAF12151.1|AE002090_7 (AE002090)
3-methyl-2-oxobutanoate hydroxymethyltransferase
[Deinococcus radiodurans]
Length = 293
Score = 216 bits (545), Expect = 2e-55
Identities = 111/253 (43%), Positives = 165/253 (64%), Gaps = 3/253 (1%)
Query: 18 IAMITAYDYPSALLADKAGFDIVFVGDSLGMVVYGEPNTLNVSMEQMVFHTRAVARAVKR 77
+ M+TAYDYP A A+ AG D++ VGDSLG VV G +T V++ M+ H +AV R
Sbjct: 35 LVMVTAYDYPGARHAEAAGVDLILVGDSLGNVVLGYDSTAPVTLADMIHHGKAVRRGAPN 94
Query: 78 ALVLADMPFGSYEVSVEEGIKNAIKLIQ-AGADAVKIEGGYDHK-KLVKRLVRMGIPVMG 135
++ D+PFG+Y V + +++A+++IQ GADAVK+EG +V+ L R G+PVMG
Sbjct: 95 TFLVVDLPFGTYHAGVTDAMRHAVRVIQETGADAVKMEGSTPEVLDVVRVLSRNGVPVMG 154
Query: 136 HTGLTPQRYLRLGGYRIMGSTEEEVEEIIRDAKALEKAGAFAVVLEFVLADVAKLVTEEV 195
H GL PQ GG R+ G ++ + A AL++AGAFAVVLE + A +A+L++E +
Sbjct: 155 HVGLMPQTAAAQGGLRVQGKDDDSARRTLEGAVALQEAGAFAVVLEAIPARLARLISERL 214
Query: 196 SIPTIGIGSGPYVDGQVLVWHDVLGLYE-ESPPFVKRYANLRDEILGAISEFKKDVKEGK 254
S+ TIGIG+G + DGQVLV+HD+LGLYE E KRYA+L E AI+ + +V+ +
Sbjct: 215 SVATIGIGAGVHCDGQVLVYHDLLGLYEGEEKKIAKRYADLGREAREAIAHYAAEVRARE 274
Query: 255 FPGREHYWEFQDK 267
FP +++ + +D+
Sbjct: 275 FPSKDNSFVMKDE 287
>pir||T50565 3-methyl-2-oxobutanoate hydroxymethyltransferase (EC 2.1.2.11)
[imported] - Streptomyces coelicolor
>gi|6469241|emb|CAB61702.1| (AL133220)
3-methyl-2-oxobutanoate hydroxymethyltransferase (EC
2.1.2.11). [Streptomyces coelicolor A3(2)]
Length = 291
Score = 215 bits (541), Expect = 6e-55
Identities = 119/262 (45%), Positives = 167/262 (63%), Gaps = 4/262 (1%)
Query: 2 REITPRKIIEMKGK-EKIAMITAYDYPSALLADKAGFDIVFVGDSLGMVVYGEPNTLNVS 60
R IT R I K + EK M+TAYD +A + D++G ++ VGDS G G T+ V+
Sbjct: 28 RRITVRDITAAKERGEKWPMLTAYDAMTASVFDESGIPVMLVGDSAGNCHLGYETTVPVT 87
Query: 61 MEQMVFHTRAVARAVKRALVLADMPFGSYEVSVEEGIKNAIKLI-QAGADAVKIEGGYDH 119
+++M + AV R RAL++ D+PFGSY+ + +++A +L+ +AG AVK+EGG
Sbjct: 88 LDEMTMLSAAVVRGTSRALIVGDLPFGSYQEGPVQALRSATRLVKEAGVGAVKLEGGERS 147
Query: 120 KKLVKRLVRMGIPVMGHTGLTPQRYLRLGGYRIMGSTEEEVEEIIRDAKALEKAGAFAVV 179
+ ++ LV GIPVM H GLTPQ +G YR+ G EE ++++RDAKA++ AGAFAVV
Sbjct: 148 HRQIELLVESGIPVMAHIGLTPQSVNSMG-YRVQGRGEEAAQQLLRDAKAVQDAGAFAVV 206
Query: 180 LEFVLADVAKLVTEEVSIPTIGIGSGPYVDGQVLVWHDVLGLY-EESPPFVKRYANLRDE 238
LE V A++A VT + IPT+GIG+GP D QVLVW D+LGL P FVK+YA+LR
Sbjct: 207 LELVPAELAAEVTRTLHIPTVGIGAGPDTDAQVLVWTDMLGLTGGRMPKFVKQYADLRKV 266
Query: 239 ILGAISEFKKDVKEGKFPGREH 260
+ A + +DV G FP EH
Sbjct: 267 MGDAAKAYAEDVVGGTFPADEH 288
>pir||F81148 3-methyl-2-oxobutanoate hydroxymethyltransferase NMB0870 [imported]
- Neisseria meningitidis (group B strain MD58)
>gi|7226107|gb|AAF41281.1| (AE002439)
3-methyl-2-oxobutanoate hydroxymethyltransferase
[Neisseria meningitidis MC58]
Length = 263
Score = 215 bits (541), Expect = 6e-55
Identities = 117/259 (45%), Positives = 162/259 (62%), Gaps = 3/259 (1%)
Query: 4 ITPRKIIEMKGK-EKIAMITAYDYPSALLADKAGFDIVFVGDSLGMVVYGEPNTLNVSME 62
IT + +MK EKIAM+TAY+ A L D AG +++ VGDSLGM V G +TL VS+
Sbjct: 2 ITVNTLQKMKAAGEKIAMLTAYESSFAALMDDAGVEMLLVGDSLGMAVQGRKSTLPVSLR 61
Query: 63 QMVFHTRAVARAVKRALVLADMPFGSYEVSVEEGIKNAIKLIQAGADAVKIEGGYDHKKL 122
M +HT VAR K A++++D+PFG+Y+ S E+ A +L+ AGA VK+EGG +
Sbjct: 62 DMCYHTECVARGAKNAMIVSDLPFGAYQQSKEQAFAAAAELMAAGAHMVKLEGGVWMAET 121
Query: 123 VKRLVRMGIPVMGHTGLTPQRYLRLGGYRIMGSTEEEVEEIIRDAKALEKAGAFAVVLEF 182
+ L GIPV H GLTPQ GGY++ G + + ++ DAKA + AGA V++E
Sbjct: 122 TEFLQMRGIPVCAHIGLTPQSVFAFGGYKVQG-RGGKAQALLNDAKAHDDAGAAVVLMEC 180
Query: 183 VLADVAKLVTEEVSIPTIGIGSGPYVDGQVLVWHDVLGLYE-ESPPFVKRYANLRDEILG 241
VLA++AK VTE VS PTIGIG+G DGQVLV HD+LG++ ++ FVK + D +
Sbjct: 181 VLAELAKKVTETVSCPTIGIGAGADCDGQVLVMHDMLGIFPGKTAKFVKNFMQGHDSVQA 240
Query: 242 AISEFKKDVKEGKFPGREH 260
A+ + +VK FP EH
Sbjct: 241 AVRAYVAEVKAKTFPAAEH 259
>pir||E81874 probable 3-methyl-2-oxobutanoate hydroxymethyltransferase (EC
2.1.2.11) NMA1088 [imported] - Neisseria meningitidis
(group A strain Z2491) >gi|7379783|emb|CAB84351.1|
(AL162755) putative 3-methyl-2-oxobutanoate
hydroxymethyltransferase [Neisseria meningitidis Z2491]
Length = 263
Score = 213 bits (536), Expect = 2e-54
Identities = 117/259 (45%), Positives = 161/259 (61%), Gaps = 3/259 (1%)
Query: 4 ITPRKIIEMKGK-EKIAMITAYDYPSALLADKAGFDIVFVGDSLGMVVYGEPNTLNVSME 62
IT + +MK EKIAM+TAY+ A L D AG D++ VGDSLGM V G +TL VS+
Sbjct: 2 ITVNTLQKMKAAGEKIAMLTAYESSFAALMDDAGVDVLLVGDSLGMAVQGRQSTLPVSLR 61
Query: 63 QMVFHTRAVARAVKRALVLADMPFGSYEVSVEEGIKNAIKLIQAGADAVKIEGGYDHKKL 122
M +HT VAR K A++++D+PFG+Y+ S E+ A +L+ AGA VK+EGG +
Sbjct: 62 DMCYHTECVARGAKNAMIVSDLPFGAYQQSKEQAFAAAAELMAAGAHMVKLEGGVWMAET 121
Query: 123 VKRLVRMGIPVMGHTGLTPQRYLRLGGYRIMGSTEEEVEEIIRDAKALEKAGAFAVVLEF 182
+ L GIPV H GLTPQ GGY++ G + + ++ DAKA + AGA V++E
Sbjct: 122 TEFLQMRGIPVCAHIGLTPQSVFAFGGYKVQG-RGGKAQALLNDAKAHDDAGAAVVLMEC 180
Query: 183 VLADVAKLVTEEVSIPTIGIGSGPYVDGQVLVWHDVLGLYE-ESPPFVKRYANLRDEILG 241
V A++AK VTE VS PTIGIG+G DGQVLV HD+LG++ ++ FVK + + I
Sbjct: 181 VPAELAKKVTESVSCPTIGIGAGVDCDGQVLVMHDMLGIFPGKTAKFVKNFMQGQSSIQA 240
Query: 242 AISEFKKDVKEGKFPGREH 260
A+ + +VK FP EH
Sbjct: 241 AVRAYVAEVKAKTFPAAEH 259
>gb|AAG19781.1| (AE005063) ketopantoate hydroxymethyltransferase-like; PanB
[Halobacterium sp. NRC-1]
Length = 274
Score = 212 bits (535), Expect = 3e-54
Identities = 111/246 (45%), Positives = 159/246 (64%), Gaps = 1/246 (0%)
Query: 16 EKIAMITAYDYPSALLADKAGFDIVFVGDSLGMVVYGEPNTLNVSMEQMVFHTRAVARAV 75
+ + M+TAYD P+A + D AG D++ VGDS+G G TL VS++++ T AVARA
Sbjct: 18 DPVTMLTAYDAPTASVVDDAGVDMILVGDSVGNAKLGYDTTLPVSVDEIASATGAVARAT 77
Query: 76 KRALVLADMPFGSYEVSVEEGIKNAIKLI-QAGADAVKIEGGYDHKKLVKRLVRMGIPVM 134
A+V+ADMPF S+ E ++NA +++ + ADAVK+E G L + L +GIPVM
Sbjct: 78 ADAVVVADMPFLSFGADETESVRNAGRMLKEEDADAVKLESGPHTVSLTETLTSLGIPVM 137
Query: 135 GHTGLTPQRYLRLGGYRIMGSTEEEVEEIIRDAKALEKAGAFAVVLEFVLADVAKLVTEE 194
H GLTPQ +LGGY G+ ++ E ++ A+ E AGAFA+VLE V A+VA +T+
Sbjct: 138 AHLGLTPQHVNQLGGYFRQGTDQDSAERMLDLARDHEAAGAFALVLEHVPANVAADITDA 197
Query: 195 VSIPTIGIGSGPYVDGQVLVWHDVLGLYEESPPFVKRYANLRDEILGAISEFKKDVKEGK 254
+ IPTIGIG+GP DGQVLV DV+G+ E SPPF K++ ++ E+ A+ ++ V+ G
Sbjct: 198 IDIPTIGIGAGPDTDGQVLVISDVIGMSERSPPFSKQFGDVNREMAAAVDDYVDAVESGS 257
Query: 255 FPGREH 260
FP EH
Sbjct: 258 FPAAEH 263
>sp|O25698|PANB_HELPY 3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE (KETOPANTOATE
HYDROXYMETHYLTRANSFERASE) >gi|7433445|pir||B64652
3-methyl-2-oxobutanoate hydroxymethyltransferase -
Helicobacter pylori (strain 26695)
>gi|2314202|gb|AAD08099.1| (AE000613)
3-methyl-2-oxobutanoate hydroxymethyltransferase (panB)
[Helicobacter pylori 26695]
Length = 270
Score = 208 bits (523), Expect = 8e-53
Identities = 111/259 (42%), Positives = 168/259 (64%), Gaps = 6/259 (2%)
Query: 1 MREITPRKIIEMKGKEKIAMITAYDYPSALLADKAGFDIVFVGDSLGMVVYGEPNTLNVS 60
+++IT + K +EKI ITAYD A + D D++ VGDSL M + + +TL+ S
Sbjct: 8 IKKITLNHLQAKKNQEKIIAITAYDALFAQIFDPL-VDVILVGDSLNMSFFNQNDTLSAS 66
Query: 61 MEQMVFHTRAVARAVKRALVLADMPFGSYEVSVEEGIKNAIKLI-QAGADAVKIEGGYDH 119
+E M++HT+AV K ++ DMPFGSY+ + +KNAI++ + A A+K+EGG +
Sbjct: 67 VEMMLYHTKAVCAGAKTPFIITDMPFGSYK-DEKTALKNAIRVYKETQASAIKLEGGKEK 125
Query: 120 KKLVKRLVRMGIPVMGHTGLTPQRYLRL-GGYRIMGSTEEEVEEIIRDAKALEKAGAFAV 178
KLVK L G+ V+GH GL PQ ++RL GGY+I G EE+ ++++ DA +LE+AG +
Sbjct: 126 AKLVKTLTNEGVIVVGHIGLMPQ-FVRLDGGYKIKGKNEEQQKKLLEDALSLEEAGVGLL 184
Query: 179 VLEFVLADVAKLVTEEVSIPTIGIGSGPYVDGQVLVWHDVLGLYEE-SPPFVKRYANLRD 237
VLE + +A+ +T+++ IPTIGIGSG DGQ+LVW D+LG ++ P FV+ Y ++
Sbjct: 185 VLEGITTPIAQKITQKIKIPTIGIGSGKDCDGQILVWSDMLGFFDSFKPKFVREYLKGKE 244
Query: 238 EILGAISEFKKDVKEGKFP 256
I AI ++ DVK+G FP
Sbjct: 245 LIQNAIKQYADDVKKGNFP 263
>sp|Q9ZM56|PANB_HELPJ 3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE (KETOPANTOATE
HYDROXYMETHYLTRANSFERASE) >gi|7433444|pir||G71942
3-methyl-2-oxobutanoate hydroxymethyltransferase -
Helicobacter pylori (strain J99)
>gi|4154887|gb|AAD05937.1| (AE001471)
3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE
[Helicobacter pylori J99]
Length = 270
Score = 205 bits (517), Expect = 4e-52
Identities = 110/259 (42%), Positives = 168/259 (64%), Gaps = 6/259 (2%)
Query: 1 MREITPRKIIEMKGKEKIAMITAYDYPSALLADKAGFDIVFVGDSLGMVVYGEPNTLNVS 60
+++IT + K +EKI ITAYD A + D D++ VGDSL M + + +TL+ S
Sbjct: 8 IKKITLSHLQAKKNQEKIIAITAYDALFAQIFDPL-VDVILVGDSLNMSFFNQNDTLSAS 66
Query: 61 MEQMVFHTRAVARAVKRALVLADMPFGSYEVSVEEGIKNAIKLI-QAGADAVKIEGGYDH 119
++ M++HT+AV K ++ DMPFGSY+ + +KNAI++ + A A+K+EGG +
Sbjct: 67 VKMMLYHTKAVCAGAKTPFIITDMPFGSYK-DEKTALKNAIRVYKETQASAIKLEGGKEK 125
Query: 120 KKLVKRLVRMGIPVMGHTGLTPQRYLRL-GGYRIMGSTEEEVEEIIRDAKALEKAGAFAV 178
KLVK L G+ V+GH GL PQ ++RL GGY+I G EE+ ++++ DA +LE+AG +
Sbjct: 126 AKLVKTLTDEGVIVVGHIGLMPQ-FVRLDGGYKIKGKNEEQQKKLLEDALSLEEAGVGLL 184
Query: 179 VLEFVLADVAKLVTEEVSIPTIGIGSGPYVDGQVLVWHDVLGLYEE-SPPFVKRYANLRD 237
VLE + +A+ +T+++ IPTIGIGSG DGQ+LVW D+LG ++ P FV+ Y ++
Sbjct: 185 VLEGITTPIAQTITQKIKIPTIGIGSGKDCDGQILVWSDMLGFFDSFKPKFVREYLKGKE 244
Query: 238 EILGAISEFKKDVKEGKFP 256
I AI ++ DVK+G FP
Sbjct: 245 LIQNAIQQYADDVKKGNFP 263
>pir||F83055 3-methyl-2-oxobutanoate hydroxymethyltransferase PA4729 [imported]
- Pseudomonas aeruginosa (strain PAO1)
>gi|9950989|gb|AAG08115.1|AE004886_7 (AE004886)
3-methyl-2-oxobutanoate hydroxymethyltransferase
[Pseudomonas aeruginosa]
Length = 266
Score = 204 bits (513), Expect = 1e-51
Identities = 112/247 (45%), Positives = 158/247 (63%), Gaps = 3/247 (1%)
Query: 16 EKIAMITAYDYPSALLADKAGFDIVFVGDSLGMVVYGEPNTLNVSMEQMVFHTRAVARAV 75
EKIAM+T YD A A +AG D++ VGDSLGMV+ G +TL VS E+M +HT V R
Sbjct: 17 EKIAMLTCYDATFAHTASQAGVDVLLVGDSLGMVLQGHDSTLPVSNEEMAYHTACVKRGN 76
Query: 76 KRALVLADMPFGSYEVSVEEGIKNAIKLIQAGADAVKIEGGYDHKKLVKRLVRMGIPVMG 135
K +L++ D+ F S SV + + +A++L+QAGA VK+EGG + + RL +MG+PV
Sbjct: 77 KGSLIVTDLAFESSH-SVAQTLADAVRLMQAGAHMVKLEGGVWLAEPIARLAQMGVPVCA 135
Query: 136 HTGLTPQRYLRLGGYRIMGSTEEEVEEIIRDAKALEKAGAFAVVLEFVLADVAKLVTEEV 195
H GLTPQ GG+++ G E + ++ DA ALE+AGA ++LE V + +A+ +T+ V
Sbjct: 136 HLGLTPQAVNLFGGFKVQGRQETQARQLRADAIALEQAGAAMLLLECVPSVLAEEITQAV 195
Query: 196 SIPTIGIGSGPYVDGQVLVWHDVLG--LYEESPPFVKRYANLRDEILGAISEFKKDVKEG 253
IP IGIG+G DGQVLV HD+LG L SP FVK + ++ I AI+ + + VK+
Sbjct: 196 KIPVIGIGAGAATDGQVLVMHDMLGLSLTGRSPKFVKDFMQGQESIPAAIAAYVRAVKDV 255
Query: 254 KFPGREH 260
FP EH
Sbjct: 256 SFPAAEH 262
>pir||T50554 3-methyl-2-oxobutanoate hydroxymethyltransferase (EC 2.1.2.11)
[imported] - Mycobacterium sp
>gi|6980036|gb|AAF34708.1|AF223945_1 (AF223945)
3-methyl-2-oxobutanoate hydroxymethyltransferase
[Mycobacterium sp. PYR-1]
Length = 280
Score = 203 bits (512), Expect = 2e-51
Identities = 106/246 (43%), Positives = 158/246 (64%), Gaps = 3/246 (1%)
Query: 17 KIAMITAYDYPSALLADKAGFDIVFVGDSLGMVVYGEPNTLNVSMEQMVFHTRAVARAVK 76
K AM+TAYDY +A + D+A ++ VGDS VVYG T+ V++++++ R V R
Sbjct: 34 KWAMLTAYDYSTAAVFDEAEIPVLLVGDSAANVVYGYDTTVPVTLDELIPLVRGVVRGAP 93
Query: 77 RALVLADMPFGSYEVSVEEGIKNAIKLI-QAGADAVKIEGGYDHKKLVKRLVRMGIPVMG 135
ALV+AD+PFGSYE ++ + A +++ + GA AVK+EGG + + GIPVM
Sbjct: 94 HALVVADLPFGSYEAGPQQALATATRMLKETGAHAVKLEGGERVADQIAAVSAAGIPVMA 153
Query: 136 HTGLTPQRYLRLGGYRIMGSTEEEVEEIIRDAKALEKAGAFAVVLEFVLADVAKLVTEEV 195
H G TPQ LGG+R+ G + E+ I DA A+++AGAFAVV+E V A++A +T ++
Sbjct: 154 HIGFTPQSVNGLGGFRVQG-RGDAAEQTIHDAIAVQEAGAFAVVMEMVPAELATQITGKL 212
Query: 196 SIPTIGIGSGPYVDGQVLVWHDVLGLYE-ESPPFVKRYANLRDEILGAISEFKKDVKEGK 254
+IPT+GIG+GP D QVLVW D+ G+ ++ FVKR+ + DE+ A S++ ++V G
Sbjct: 213 TIPTVGIGAGPSCDAQVLVWQDMAGMTNGKTAKFVKRFGAVGDELRRAASDYAREVATGA 272
Query: 255 FPGREH 260
FP EH
Sbjct: 273 FPADEH 278
>pir||A47152 3-methyl-2-oxobutanoate hydroxymethyltransferase (EC 2.1.2.11) -
Escherichia coli >gi|296059|emb|CAA46505.1| (X65538)
3-methyl-2-oxobutanoate hydroxymethyltransferase
[Escherichia coli]
Length = 264
Score = 203 bits (510), Expect = 3e-51
Identities = 107/247 (43%), Positives = 153/247 (61%), Gaps = 2/247 (0%)
Query: 15 KEKIAMITAYDYPSALLADKAGFDIVFVGDSLGMVVYGEPNTLNVSMEQMVFHTRAVARA 74
K++ A ITAYDY A L G +++ VGDSLGM V G +TL V++E + +HT AV R
Sbjct: 16 KKRFATITAYDYSFAKLFADEGLNVMLVGDSLGMTVQGHDSTLPVTVEDIAYHTAAVRRG 75
Query: 75 VKRALVLADMPFGSYEVSVEEGIKNAIKLIQAGADAVKIEGGYDHKKLVKRLVRMGIPVM 134
L+LAD+PF +Y + E+ +NA +++AGA+ VKIEGG + VK L +PV
Sbjct: 76 APNCLLLADLPFMAY-ATPEQAFENAATVMRAGANMVKIEGGEWLVETVKMLTERAVPVC 134
Query: 135 GHTGLTPQRYLRLGGYRIMGSTEEEVEEIIRDAKALEKAGAFAVVLEFVLADVAKLVTEE 194
GH GLTPQ GGY++ G +E ++++ DA ALE AGA +VLE V ++AK +TE
Sbjct: 135 GHLGLTPQSVNIFGGYKVQGRGDEAGDQLLSDALALEAAGAQLLVLECVPVELAKRITEA 194
Query: 195 VSIPTIGIGSGPYVDGQVLVWHDVLGLY-EESPPFVKRYANLRDEILGAISEFKKDVKEG 253
++IP IGIG+G DGQ+LV HD G+ P F K + +I A+ ++ +V+ G
Sbjct: 195 LAIPVIGIGAGNVTDGQILVMHDAFGITGGHIPKFAKNFLAETGDIRAAVRQYMAEVESG 254
Query: 254 KFPGREH 260
+PG EH
Sbjct: 255 VYPGEEH 261
>sp|Q10505|PANB_MYCTU 3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE (KETOPANTOATE
HYDROXYMETHYLTRANSFERASE) >gi|7433452|pir||E70776
probable panB protein - Mycobacterium tuberculosis
(strain H37RV) >gi|1261927|emb|CAA94648.1| (Z70692) panB
[Mycobacterium tuberculosis] >gi|1336206|gb|AAB01232.1|
(U57435) 3-methyl-2-oxobutanoate
hydroxymethyltransferase [Mycobacterium bovis]
Length = 281
Score = 203 bits (510), Expect = 3e-51
Identities = 109/246 (44%), Positives = 156/246 (63%), Gaps = 3/246 (1%)
Query: 17 KIAMITAYDYPSALLADKAGFDIVFVGDSLGMVVYGEPNTLNVSMEQMVFHTRAVARAVK 76
K AM+TAYDY +A + D+AG ++ VGDS VVYG T+ +S+++++ R V R
Sbjct: 35 KWAMLTAYDYSTARIFDEAGIPVLLVGDSAANVVYGYDTTVPISIDELIPLVRGVVRGAP 94
Query: 77 RALVLADMPFGSYEVSVEEGIKNAIKLIQ-AGADAVKIEGGYDHKKLVKRLVRMGIPVMG 135
ALV+AD+PFGSYE + A + ++ GA AVK+EGG + + L GIPVM
Sbjct: 95 HALVVADLPFGSYEAGPTAALAAATRFLKDGGAHAVKLEGGERVAEQIACLTAAGIPVMA 154
Query: 136 HTGLTPQRYLRLGGYRIMGSTEEEVEEIIRDAKALEKAGAFAVVLEFVLADVAKLVTEEV 195
H G TPQ LGG+R+ G + E+ I DA A+ +AGAFAVV+E V A++A +T ++
Sbjct: 155 HIGFTPQSVNTLGGFRVQG-RGDAAEQTIADAIAVAEAGAFAVVMEMVPAELATQITGKL 213
Query: 196 SIPTIGIGSGPYVDGQVLVWHDVLGLY-EESPPFVKRYANLRDEILGAISEFKKDVKEGK 254
+IPT+GIG+GP DGQVLVW D+ G ++ FVKRYA++ E+ A ++ ++V G
Sbjct: 214 TIPTVGIGAGPNCDGQVLVWQDMAGFSGAKTARFVKRYADVGGELRRAAMQYAQEVAGGV 273
Query: 255 FPGREH 260
FP EH
Sbjct: 274 FPADEH 279
>sp|P31057|PANB_ECOLI 3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE (KETOPANTOATE
HYDROXYMETHYLTRANSFERASE) >gi|7433442|pir||F64736
3-methyl-2-oxobutanoate hydroxymethyltransferase (EC
2.1.2.11) - Escherichia coli >gi|304927|gb|AAA24271.1|
(L17086) alpha-ketopantoate hydroxymethyl transferase
[Escherichia coli] >gi|1786326|gb|AAC73245.1| (AE000122)
3-methyl-2-oxobutanoate hydroxymethyltransferase
[Escherichia coli K12]
Length = 264
Score = 199 bits (500), Expect = 4e-50
Identities = 105/247 (42%), Positives = 152/247 (61%), Gaps = 2/247 (0%)
Query: 15 KEKIAMITAYDYPSALLADKAGFDIVFVGDSLGMVVYGEPNTLNVSMEQMVFHTRAVARA 74
K++ A ITAYDY A L G +++ VGDSLGM V G +TL V++ + +HT AV R
Sbjct: 16 KKRFATITAYDYSFAKLFADEGLNVMLVGDSLGMTVQGHDSTLPVTVADIAYHTAAVRRG 75
Query: 75 VKRALVLADMPFGSYEVSVEEGIKNAIKLIQAGADAVKIEGGYDHKKLVKRLVRMGIPVM 134
L+LAD+PF +Y + E+ +NA +++AGA+ VKIEGG + V+ L +PV
Sbjct: 76 APNCLLLADLPFMAY-ATPEQAFENAATVMRAGANMVKIEGGEWLVETVQMLTERAVPVC 134
Query: 135 GHTGLTPQRYLRLGGYRIMGSTEEEVEEIIRDAKALEKAGAFAVVLEFVLADVAKLVTEE 194
GH GLTPQ GGY++ G +E ++++ DA ALE AGA +VLE V ++AK +TE
Sbjct: 135 GHLGLTPQSVNIFGGYKVQGRGDEAGDQLLSDALALEAAGAQLLVLECVPVELAKRITEA 194
Query: 195 VSIPTIGIGSGPYVDGQVLVWHDVLGLY-EESPPFVKRYANLRDEILGAISEFKKDVKEG 253
++IP IGIG+G DGQ+LV HD G+ P F K + +I A+ ++ +V+ G
Sbjct: 195 LAIPVIGIGAGNVTDGQILVMHDAFGITGGHIPKFAKNFLAETGDIRAAVRQYMAEVESG 254
Query: 254 KFPGREH 260
+PG EH
Sbjct: 255 VYPGEEH 261
>sp|Q9ZEP8|PANB_PSEFL 3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE (KETOPANTOATE
HYDROXYMETHYLTRANSFERASE) >gi|3970812|emb|CAA10222.1|
(AJ130846) 3-methyl-2-oxobutanoate
hydroxymethyltransferase [Pseudomonas fluorescens]
Length = 266
Score = 199 bits (500), Expect = 4e-50
Identities = 108/259 (41%), Positives = 162/259 (61%), Gaps = 4/259 (1%)
Query: 4 ITPRKIIEMKGKEKIAMITAYDYPSALLADKAGFDIVFVGDSLGMVVYGEPNTLNVSMEQ 63
+T + +++KG EKI M+T YD A + +AG +++ VGDSLGMV+ G +TL V+ ++
Sbjct: 6 LTTLQSLKLKG-EKITMLTCYDATFAHASCQAGIEVLLVGDSLGMVLQGNDSTLPVTTDE 64
Query: 64 MVFHTRAVARAVKRALVLADMPFGSYEVSVEEGIKNAIKLIQAGADAVKIEGGYDHKKLV 123
+ +HT +V R A ++AD+PF Y ++E+ +NA KL+QAGA +K+EG + +
Sbjct: 65 LAYHTASVKRGNDGAFIIADLPFMGY-ATLEQTFQNAGKLMQAGAHMIKVEGAVWLAESI 123
Query: 124 KRLVRMGIPVMGHTGLTPQRYLRLGGYRIMGSTEEEVEEIIRDAKALEKAGAFAVVLEFV 183
+ L G+PV H GLTPQ LGGY++ G E + ++ DA ALE+AGA ++LE V
Sbjct: 124 RLLAERGVPVCAHMGLTPQSVNLLGGYKVQGRNEAQARQMRADAIALEQAGAAMILLECV 183
Query: 184 LADVAKLVTEEVSIPTIGIGSGPYVDGQVLVWHDVLGL--YEESPPFVKRYANLRDEILG 241
+++A +T+ V +P IGIG+G DGQVLV HD+LGL P FVK + + I
Sbjct: 184 PSELAAEITQAVKVPVIGIGAGSATDGQVLVLHDMLGLSITGRVPKFVKNFMTGQASIHD 243
Query: 242 AISEFKKDVKEGKFPGREH 260
A+S + +VK FPG EH
Sbjct: 244 ALSAYVAEVKGVTFPGAEH 262
>sp|Q09672|PANB_SCHPO PROBABLE 3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE
(KETOPANTOATE HYDROXYMETHYLTRANSFERASE)
>gi|1076894|pir||S55487 probable 3-methyl-2-oxobutanoate
hydroxymethyltransferase (EC 2.1.2.11) - fission yeast
(Schizosaccharomyces pombe) >gi|854608|emb|CAA89959.1|
(Z49811) 3-methyl-2-oxobutanoate
hydroxymethyltransferase [Schizosaccharomyces pombe]
Length = 267
Score = 196 bits (494), Expect = 2e-49
Identities = 108/266 (40%), Positives = 163/266 (60%), Gaps = 4/266 (1%)
Query: 1 MREITPRKIIEMK-GKEKIAMITAYDYPSALLADKAGFDIVFVGDSLGMVVYGEPNTLNV 59
+++IT + + K +K A ITAYD + L + G ++ VGDSLGM G TL V
Sbjct: 3 LKQITISTLRQWKLANKKFACITAYDASFSRLFAEQGMPVMLVGDSLGMTAQGHSTTLPV 62
Query: 60 SMEQMVFHTRAVARAVKRALVLADMPFGSYEVSVEEGIKNAIKLIQAGADAVKIEGGYDH 119
S+E + +HT++V R L++AD+PF SY + E+ KNA +++AGA+ VKIEGG +
Sbjct: 63 SVEDIAYHTKSVRRGAPNRLLMADLPFMSYS-TWEDACKNAATVMRAGANIVKIEGGGNW 121
Query: 120 K-KLVKRLVRMGIPVMGHTGLTPQRYLRLGGYRIMGSTEEEVEEIIRDAKALEKAGAFAV 178
++V+RL +PV GH GLTPQ GGY+I G + +I +A+ LEK GA +
Sbjct: 122 IFEIVQRLTERSVPVAGHLGLTPQSVNIFGGYKIQGREQSAAARLIENAQQLEKFGAQLL 181
Query: 179 VLEFVLADVAKLVTEEVSIPTIGIGSGPYVDGQVLVWHDVLGLYEESPP-FVKRYANLRD 237
VLE + +A+ +T+ +SIPTIGIG+G + DGQ+LV HD LG+ PP F K + +
Sbjct: 182 VLECIPESLAEQITKTISIPTIGIGAGKHTDGQILVMHDALGITGGRPPKFAKNFLSGAG 241
Query: 238 EILGAISEFKKDVKEGKFPGREHYWE 263
+I AI + +V++G +P EH ++
Sbjct: 242 DIRTAIQRYIYEVEQGLYPAEEHSFQ 267
>pir||E82832 3-methyl-2-oxobutanoate hydroxymethyltransferase XF0229 [imported]
- Xylella fastidiosa (strain 9a5c)
>gi|9105038|gb|AAF83042.1|AE003876_7 (AE003876)
3-methyl-2-oxobutanoate hydroxymethyltransferase
[Xylella fastidiosa]
Length = 246
Score = 196 bits (494), Expect = 2e-49
Identities = 107/243 (44%), Positives = 150/243 (61%), Gaps = 3/243 (1%)
Query: 20 MITAYDYPSALLADKAGFDIVFVGDSLGMVVYGEPNTLNVSMEQMVFHTRAVARAVKRAL 79
M+TAYD A + D G D+V VGDSLGMVV G +TL VS+ MV+HT VAR V++A+
Sbjct: 1 MLTAYDAGFARILDANGVDLVLVGDSLGMVVQGHDSTLPVSVHDMVYHTACVARGVRQAM 60
Query: 80 VLADMPFGSYEVSVEEGIKNAIKLIQAGADAVKIEGGYDHKKLVKRLVRMGIPVMGHTGL 139
++ D+PF + + S E ++ A L++ GA +KIEG +++ LV IPV H GL
Sbjct: 61 LVVDLPFQA-DASPERALEAATPLLRVGAQMIKIEGAGHKLEVISYLVEREIPVCSHLGL 119
Query: 140 TPQRYLRLGGYRIMGSTEEEVEEIIRDAKALEKAGAFAVVLEFVLADVAKLVTEEVSIPT 199
TPQ LR GGY++ G EE + +A+A +AGA ++LE V + +A +T +VS+PT
Sbjct: 120 TPQSVLRFGGYKVQGRGEEAGGRLRAEARAAVEAGATLLLLECVPSQLAAQITTDVSVPT 179
Query: 200 IGIGSGPYVDGQVLVWHDVLGL--YEESPPFVKRYANLRDEILGAISEFKKDVKEGKFPG 257
IGIG+G DGQVLV HD+LGL P FVK + + GA+ + V++G FP
Sbjct: 180 IGIGAGAGCDGQVLVLHDLLGLDSGHPRPKFVKDFLAHGGSVAGAVRAYANAVRDGSFPD 239
Query: 258 REH 260
EH
Sbjct: 240 VEH 242
>pir||A82304 3-methyl-2-oxobutanoate hydroxymethyltransferase VC0592 [imported]
- Vibrio cholerae (group O1 strain N16961)
>gi|9655023|gb|AAF93759.1| (AE004144)
3-methyl-2-oxobutanoate hydroxymethyltransferase [Vibrio
cholerae]
Length = 264
Score = 194 bits (487), Expect = 1e-48
Identities = 106/262 (40%), Positives = 160/262 (60%), Gaps = 3/262 (1%)
Query: 1 MREITPRKIIEMKGK-EKIAMITAYDYPSALLADKAGFDIVFVGDSLGMVVYGEPNTLNV 59
M++IT +++ K + K A TAYD A L + ++ VGDSLGMV+ GE +TL V
Sbjct: 1 MKKITINDLMKWKQEGRKFATSTAYDASFAQLFESQEMPVLLVGDSLGMVLQGETDTLPV 60
Query: 60 SMEQMVFHTRAVARAVKRALVLADMPFGSYEVSVEEGIKNAIKLIQAGADAVKIEGGYDH 119
+++ + +HTR V + L++ADMPF SY + E+ +NA KL++AGA+ VKIEGG
Sbjct: 61 TVDDIAYHTRCVRKGSPNCLLMADMPFMSY-ATPEQACENAAKLVRAGANMVKIEGGDWL 119
Query: 120 KKLVKRLVRMGIPVMGHTGLTPQRYLRLGGYRIMGSTEEEVEEIIRDAKALEKAGAFAVV 179
VK L +PV H GLTPQ GGY++ G +++ + ++RDA AL++AGA V+
Sbjct: 120 VDTVKMLTERAVPVCAHLGLTPQSVNIFGGYKVQGREQDKADRMVRDALALQEAGAQIVL 179
Query: 180 LEFVLADVAKLVTEEVSIPTIGIGSGPYVDGQVLVWHDVLGLYEE-SPPFVKRYANLRDE 238
LE V A++A +T+ + +P IGIG+G DGQ+LV HD+ G+ P F K + +
Sbjct: 180 LECVPAELANRITQILDVPVIGIGAGNGTDGQILVMHDMFGISANYMPKFSKNFLAETGD 239
Query: 239 ILGAISEFKKDVKEGKFPGREH 260
I A++++ +DV G FP H
Sbjct: 240 IRQAVAKYIEDVASGAFPDLAH 261
>sp|P57293|PANB_BUCAI 3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE (KETOPANTOATE
HYDROXYMETHYLTRANSFERASE) >gi|10038879|dbj|BAB12914.1|
(AP001118) 3-methyl-2-oxobutanoate
hydroxymethyltransferase [Buchnera sp. APS]
Length = 263
Score = 192 bits (484), Expect = 3e-48
Identities = 98/262 (37%), Positives = 160/262 (60%), Gaps = 3/262 (1%)
Query: 1 MREITPRKIIEMK-GKEKIAMITAYDYPSALLADKAGFDIVFVGDSLGMVVYGEPNTLNV 59
M IT ++ K K+K A ITAYD+ + L G ++ +GDSLGM + G +TL V
Sbjct: 1 MESITISQLKNWKINKKKFAAITAYDFSFSRLFSNCGIPVILIGDSLGMTIQGHTSTLPV 60
Query: 60 SMEQMVFHTRAVARAVKRALVLADMPFGSYEVSVEEGIKNAIKLIQAGADAVKIEGGYDH 119
+E + +HT+AV + +++D+PF SY ++ +KN K+I++GA+ +K+EGG
Sbjct: 61 KIEDIAYHTKAVRKGAPNTFLISDLPFMSY-YDTKQALKNTAKIIRSGANMIKMEGGKWL 119
Query: 120 KKLVKRLVRMGIPVMGHTGLTPQRYLRLGGYRIMGSTEEEVEEIIRDAKALEKAGAFAVV 179
++++ L I + GH GL PQ + LGGY++ G E + ++I +A LE++G ++
Sbjct: 120 IEIIRELSNRLILICGHIGLIPQSFHYLGGYKVQGRKENDANKLIDEALLLEESGINMLI 179
Query: 180 LEFVLADVAKLVTEEVSIPTIGIGSGPYVDGQVLVWHDVLGLYE-ESPPFVKRYANLRDE 238
LE + +AK +TE +SIP IGIGSG DGQ+LV HD+LG+ E ++P F K + + D
Sbjct: 180 LECIPEKLAKKITESLSIPVIGIGSGKNTDGQILVMHDLLGITEGKTPSFTKNFLSESDS 239
Query: 239 ILGAISEFKKDVKEGKFPGREH 260
I AI ++ +V+ +P ++H
Sbjct: 240 IQKAIQKYIYEVEHSIYPSKKH 261
>pir||T51696 3-methyl-2-oxobutanoate hydroxymethyltransferase (EC 2.1.2.11)
[imported] - Prochlorococcus sp
>gi|5912565|emb|CAB56202.1| (AJ011025)
3-methyl-2-oxobutanoate hydroxymethyltransferase
[Prochlorococcus sp.]
Length = 257
Score = 189 bits (475), Expect = 3e-47
Identities = 106/233 (45%), Positives = 154/233 (65%), Gaps = 9/233 (3%)
Query: 6 PRKIIEMKGK-EKIAMITAYDYPSALLADKAGFDIVFVGDSLGMVVYGEPNTLNVSMEQM 64
P ++++ K K +KI +TA+D S LA+ +G DIV VGDSL MV G +TL V++E M
Sbjct: 3 PSELVKYKKKSQKIIALTAWDSISGSLAEHSGADIVLVGDSLAMVCLGYKSTLPVTLENM 62
Query: 65 VFHTRAVARAVKR-----ALVLADMPFGSYEVSVEEGIKNAIKLIQ-AGADAVKIEGGYD 118
++HT AV+R + +L++ DMPF +Y+ + ++ A K+I+ A AVK+EG
Sbjct: 63 IYHTNAVSRGFSKEIEEQSLLVCDMPFLTYQCGENKAVEYAGKIIKNTYAKAVKVEGADP 122
Query: 119 H-KKLVKRLVRMGIPVMGHTGLTPQRYLRLGGYRIMGSTEEEVEEIIRDAKALEKAGAFA 177
+ ++ RL+RMGIPVMGH GLTPQ YL LG ++ G+ E E+I RDA +LEK G F+
Sbjct: 123 EVQNVISRLIRMGIPVMGHLGLTPQSYLNLG-FKQQGNNSESHEKIKRDALSLEKLGCFS 181
Query: 178 VVLEFVLADVAKLVTEEVSIPTIGIGSGPYVDGQVLVWHDVLGLYEESPPFVK 230
+VLE + +AK + E+ IPTIGIG+G + DGQV V D+LGL ++ PPF +
Sbjct: 182 IVLEHIPELLAKEIQTELEIPTIGIGAGKFCDGQVRVTADLLGLNDKQPPFCR 234
>gi|6319653 Probable 3-methyl-2-oxobutanoate hydroxymethyltransferase (EC
2.1.2.11); Ecm31p [Saccharomyces cerevisiae]
>gi|585643|sp|P38122|PANB_YEAST 3-METHYL-2-OXOBUTANOATE
HYDROXYMETHYLTRANSFERASE (KETOPANTOATE
HYDROXYMETHYLTRANSFERASE) >gi|626788|pir||S46047
probable 3-methyl-2-oxobutanoate
hydroxymethyltransferase (EC 2.1.2.11) - yeast
(Saccharomyces cerevisiae) >gi|536525|emb|CAA85137.1|
(Z36045) ORF YBR176w [Saccharomyces cerevisiae]
Length = 312
Score = 177 bits (444), Expect = 1e-43
Identities = 98/261 (37%), Positives = 159/261 (60%), Gaps = 10/261 (3%)
Query: 18 IAMITAYDYPSALLADKAGFDIVFVGDSLGMVVYGEPNTLNVSMEQMVFHTRAVARAVKR 77
++M TAYD+ +A +KA D++ VGDSL M G +T+ +S+ + +H +V RA
Sbjct: 41 LSMCTAYDFITATWVNKANCDLLLVGDSLAMTSLGYDSTITLSLNEFKYHVASVCRAEGS 100
Query: 78 ALVLADMPFGSYEVSVEEGIKNAIKL--IQAGADAVKIEGGYDHK-----KLVKRLVRMG 130
++V+ DMPFG++E + +G+KNAI + + + +VK+E G K K ++ L G
Sbjct: 101 SMVVVDMPFGTFESGISDGLKNAIDIMKLDSKVTSVKVEVGSYTKDKYAMKFIEELCSRG 160
Query: 131 IPVMGHTGLTPQRYLRLGGYRIMGSTE-EEVEEIIRDAKALEKAGAFAVVLEFVLADVAK 189
IPVM H GLTPQ+ LGGY++ GS +++E+ A L+K G +++++E V +A+
Sbjct: 161 IPVMAHIGLTPQKVHSLGGYKVQGSKSLLQMQELYETAMQLQKIGCWSILIECVPHKMAQ 220
Query: 190 LVTEEVSIPTIGIGSGPYVDGQVLVWHDVLGLYEES-PPFVKRYANLRDEILGAISEFKK 248
+T ++S+PTIGIG+G GQVLV D+LG+ +S P FVK+ N+ D + E+
Sbjct: 221 FITSKLSVPTIGIGAGNGTSGQVLVISDLLGMQGDSVPKFVKQAVNMTDIATQGLKEYIA 280
Query: 249 DVKEGKFPGREHYWEFQDKEE 269
V++ FP R + F+ KE+
Sbjct: 281 SVEDRTFPERGTH-TFKVKED 300
>gb|AAA85381.1| (L47126) orf3 gene product [Synechocystis sp.]
Length = 167
Score = 131 bits (325), Expect = 1e-29
Identities = 74/164 (45%), Positives = 107/164 (65%), Gaps = 4/164 (2%)
Query: 4 ITPRKIIEMKGKEK-IAMITAYDYPSALLADKAGFDIVFVGDSLGMVVYGEPNTLNVSME 62
ITP ++++ K +++ I +TA+D A + D AG +I+ VGDSLGMV G TL VS++
Sbjct: 3 ITPTQLLDWKRQQRPIVALTAWDTAIASVLDAAGVEIILVGDSLGMVALGYETTLPVSLD 62
Query: 63 QMVFHTRAVARAVKRALVLADMPFGSYEVSVEEGIKNAIKLIQ-AGADAVKIEGGYDHK- 120
M+ HT AV R V+RALV+ D+PF +Y+ S + + +A +++Q GA AVK+EGG+
Sbjct: 63 TMIHHTAAVKRGVQRALVVCDLPFLTYQESPAQAMGSAGRVLQETGAQAVKLEGGHPRMV 122
Query: 121 KLVKRLVRMGIPVMGHTGLTPQRYLRLGGYRIMGSTEEEVEEII 164
+ V RL +GIPVMGH GLTPQ +L GYR G E+I+
Sbjct: 123 ETVARLTEVGIPVMGHVGLTPQSVHQL-GYRQQGQDPATAEKIL 165
>emb|CAB62149.1| (AJ245666) hypothetical protein [Sinorhizobium meliloti]
Length = 266
Score = 118 bits (294), Expect = 6e-26
Identities = 85/275 (30%), Positives = 124/275 (44%), Gaps = 32/275 (11%)
Query: 2 REITPRKIIEMKGKEKIAMITAYDYPSALLADKAGFDIVFVGDSLGMVVYGEPNTLNVSM 61
R T ++ MKGK ++ M+ A A+KA D+V V +L + E
Sbjct: 4 RRPTVADLLSMKGKRQLTMLRVMTLEEAEAAEKARIDLVSVPPALLGPEFRE-------- 55
Query: 62 EQMVFHTRAVARAVKRALVLADMPFGSYEVSVEEGIKNAIKLIQAGADAVKIEGGYDHKK 121
A + +G + V+ E+ I+ A + ++AG DAV
Sbjct: 56 ------------AAPSVFAFPGLEYGDH-VTAEDYIRAAFQALKAGGDAVYCAASLS--- 99
Query: 122 LVKRLVRMGIPVMGHTGLTPQRYLRLGGYRIMGSTEEEVEEIIRDAKALEKAGAFAVVLE 181
V+R+ GIPV GH GL P + GG+R +G T EI R KALE+AGAFA +E
Sbjct: 100 TVRRMRDEGIPVCGHVGLIPSKVTWTGGFRAVGKTAASALEIWRQTKALEEAGAFAAEIE 159
Query: 182 FVLADVAKLVTEEVSIPTIGIGSGPYVDGQVLVWHDVLGLYEESPP--------FVKRYA 233
V +VA ++ S+ + +G+G D Q L DVLG P F Y
Sbjct: 160 VVPGEVAAAISARTSMLMLSMGAGTGCDAQYLFAEDVLGANRGHYPRHAKTYRNFAAEYD 219
Query: 234 NLRDEILGAISEFKKDVKEGKFPGREHYWEFQDKE 268
L+ E + A SEF DV+ G +P + H ++KE
Sbjct: 220 RLQQERIAAFSEFAFDVRSGAYPEKGHLVGIEEKE 254
Database: ./suso.pep
Posted date: Jul 6, 2001 5:57 PM
Number of letters in database: 840,471
Number of sequences in database: 2977
Database: /banques/blast2/nr.pep
Posted date: Dec 14, 2000 12:46 PM
Number of letters in database: 188,266,275
Number of sequences in database: 595,510
Lambda K H
0.319 0.139 0.393
Gapped
Lambda K H
0.270 0.0470 0.230
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 100059955
Number of Sequences: 2977
Number of extensions: 4083951
Number of successful extensions: 11199
Number of sequences better than 1.0e-10: 36
Number of HSP's better than 0.0 without gapping: 36
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 11083
Number of HSP's gapped (non-prelim): 36
length of query: 282
length of database: 189,106,746
effective HSP length: 56
effective length of query: 226
effective length of database: 155,591,474
effective search space: 35163673124
effective search space used: 35163673124
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 41 (21.7 bits)
S2: 164 (68.3 bits)