BLASTP 2.0.10 [Aug-26-1999]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= PAB0570 (panB) DE:3-METHYL-2-OXOBUTANOATE
HYDROXYMETHYLTRANSFERASE (EC 2.1.2.11)
         (282 letters)

Database: ./suso.pep; /banques/blast2/nr.pep
           598,487 sequences; 189,106,746 total letters

Searching..................................................done

                                                                   Score     E
Sequences producing significant alignments:                        (bits)  Value

pir||B75131 3-methyl-2-oxobutanoate hydroxymethyltransferase (EC...   561  e-159
sp|O58665|PANB_PYRHO 3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSF...   519  e-146
sp|Q9X251|PANB_THEMA 3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSF...   293  2e-78
gb|AAK42546.1| Ketopantoate hydroxymethyltransferase (panB) [Sul...   293  2e-78
sp|Q9YE97|PANB_AERPE 3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSF...   286  3e-76
sp|Q9Y7B6|PANB_EMENI 3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSF...   232  4e-60
sp|O67783|PANB_AQUAE 3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSF...   231  9e-60
dbj|BAB05406.1| (AP001512) ketopantoate hydroxymethyltransferase...   227  1e-58
pir||T47945 3-methyl-2-oxobutanoate hydroxy-methyl-transferase-l...   226  3e-58
sp|P52996|PANB_BACSU 3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSF...   226  3e-58
pir||F81448 3-methyl-2-oxobutanoate hydroxymethyltransferase (EC...   224  7e-58
gb|AAC62893.1| (AC005397) 3-methyl-2-oxobutanoate hydroxy-methyl...   223  2e-57
pir||C83447 conserved hypothetical protein PA1598 [imported] - P...   222  3e-57
sp|Q9X712|PANB_CORGL 3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSF...   219  3e-56
sp|P52997|PANB_SYNY3 3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSF...   218  5e-56
pir||E75253 3-methyl-2-oxobutanoate hydroxymethyltransferase - D...   216  2e-55
pir||T50565 3-methyl-2-oxobutanoate hydroxymethyltransferase (EC...   215  6e-55
pir||F81148 3-methyl-2-oxobutanoate hydroxymethyltransferase NMB...   215  6e-55
pir||E81874 probable 3-methyl-2-oxobutanoate hydroxymethyltransf...   213  2e-54
gb|AAG19781.1| (AE005063) ketopantoate hydroxymethyltransferase-...   212  3e-54
sp|O25698|PANB_HELPY 3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSF...   208  8e-53
sp|Q9ZM56|PANB_HELPJ 3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSF...   205  4e-52
pir||F83055 3-methyl-2-oxobutanoate hydroxymethyltransferase PA4...   204  1e-51
pir||T50554 3-methyl-2-oxobutanoate hydroxymethyltransferase (EC...   203  2e-51
pir||A47152 3-methyl-2-oxobutanoate hydroxymethyltransferase (EC...   203  3e-51
sp|Q10505|PANB_MYCTU 3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSF...   203  3e-51
sp|P31057|PANB_ECOLI 3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSF...   199  4e-50
sp|Q9ZEP8|PANB_PSEFL 3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSF...   199  4e-50
sp|Q09672|PANB_SCHPO PROBABLE 3-METHYL-2-OXOBUTANOATE HYDROXYMET...   196  2e-49
pir||E82832 3-methyl-2-oxobutanoate hydroxymethyltransferase XF0...   196  2e-49
pir||A82304 3-methyl-2-oxobutanoate hydroxymethyltransferase VC0...   194  1e-48
sp|P57293|PANB_BUCAI 3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSF...   192  3e-48
pir||T51696 3-methyl-2-oxobutanoate hydroxymethyltransferase (EC...   189  3e-47
gi|6319653 Probable 3-methyl-2-oxobutanoate hydroxymethyltransfe...   177  1e-43
gb|AAA85381.1| (L47126) orf3 gene product [Synechocystis sp.]         131  1e-29
emb|CAB62149.1| (AJ245666) hypothetical protein [Sinorhizobium m...   118  6e-26

>pir||B75131 3-methyl-2-oxobutanoate hydroxymethyltransferase (EC 2.1.2.11)
           PAB0570 - Pyrococcus abyssi (strain Orsay)
           >gi|5458274|emb|CAB49763.1| (AJ248285)
           3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE (EC
           2.1.2.11) [Pyrococcus abyssi]
           Length = 282
           
 Score =  561 bits (1430), Expect = e-159
 Identities = 282/282 (100%), Positives = 282/282 (100%)

Query: 1   MREITPRKIIEMKGKEKIAMITAYDYPSALLADKAGFDIVFVGDSLGMVVYGEPNTLNVS 60
           MREITPRKIIEMKGKEKIAMITAYDYPSALLADKAGFDIVFVGDSLGMVVYGEPNTLNVS
Sbjct: 1   MREITPRKIIEMKGKEKIAMITAYDYPSALLADKAGFDIVFVGDSLGMVVYGEPNTLNVS 60

Query: 61  MEQMVFHTRAVARAVKRALVLADMPFGSYEVSVEEGIKNAIKLIQAGADAVKIEGGYDHK 120
           MEQMVFHTRAVARAVKRALVLADMPFGSYEVSVEEGIKNAIKLIQAGADAVKIEGGYDHK
Sbjct: 61  MEQMVFHTRAVARAVKRALVLADMPFGSYEVSVEEGIKNAIKLIQAGADAVKIEGGYDHK 120

Query: 121 KLVKRLVRMGIPVMGHTGLTPQRYLRLGGYRIMGSTEEEVEEIIRDAKALEKAGAFAVVL 180
           KLVKRLVRMGIPVMGHTGLTPQRYLRLGGYRIMGSTEEEVEEIIRDAKALEKAGAFAVVL
Sbjct: 121 KLVKRLVRMGIPVMGHTGLTPQRYLRLGGYRIMGSTEEEVEEIIRDAKALEKAGAFAVVL 180

Query: 181 EFVLADVAKLVTEEVSIPTIGIGSGPYVDGQVLVWHDVLGLYEESPPFVKRYANLRDEIL 240
           EFVLADVAKLVTEEVSIPTIGIGSGPYVDGQVLVWHDVLGLYEESPPFVKRYANLRDEIL
Sbjct: 181 EFVLADVAKLVTEEVSIPTIGIGSGPYVDGQVLVWHDVLGLYEESPPFVKRYANLRDEIL 240

Query: 241 GAISEFKKDVKEGKFPGREHYWEFQDKEEFKRIKESVLRKVD 282
           GAISEFKKDVKEGKFPGREHYWEFQDKEEFKRIKESVLRKVD
Sbjct: 241 GAISEFKKDVKEGKFPGREHYWEFQDKEEFKRIKESVLRKVD 282


>sp|O58665|PANB_PYRHO 3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE (KETOPANTOATE
           HYDROXYMETHYLTRANSFERASE) >gi|7433450|pir||B71086
           probable 3-methyl-2-oxobutanoate
           hydroxymethyltransferase - Pyrococcus horikoshii
           >gi|3257365|dbj|BAA30048.1| (AP000004) 283aa long
           hypothetical 3-methyl-2-oxobutanoate
           hydroxymethyltransferase [Pyrococcus horikoshii]
           Length = 283
           
 Score =  519 bits (1322), Expect = e-146
 Identities = 251/282 (89%), Positives = 275/282 (97%)

Query: 1   MREITPRKIIEMKGKEKIAMITAYDYPSALLADKAGFDIVFVGDSLGMVVYGEPNTLNVS 60
           MREITP++I EMKGKEKI MITAYDYPSALLADKAGFDIVF+GDSLGMVVYGEP+TLNV+
Sbjct: 1   MREITPKRIREMKGKEKITMITAYDYPSALLADKAGFDIVFIGDSLGMVVYGEPSTLNVT 60

Query: 61  MEQMVFHTRAVARAVKRALVLADMPFGSYEVSVEEGIKNAIKLIQAGADAVKIEGGYDHK 120
           MEQM+FHTRAVA+AVKRALVLADMPFGSYEVSVEEGIKNAIKL+QAGADAVKIEGGYDH+
Sbjct: 61  MEQMIFHTRAVAKAVKRALVLADMPFGSYEVSVEEGIKNAIKLVQAGADAVKIEGGYDHR 120

Query: 121 KLVKRLVRMGIPVMGHTGLTPQRYLRLGGYRIMGSTEEEVEEIIRDAKALEKAGAFAVVL 180
           KLVK+LVR+GIPVMGHTGLTPQRYLRLGGYRIMG TEEEVEEI+RDAKALEKAGAFA+VL
Sbjct: 121 KLVKKLVRIGIPVMGHTGLTPQRYLRLGGYRIMGGTEEEVEEILRDAKALEKAGAFAIVL 180

Query: 181 EFVLADVAKLVTEEVSIPTIGIGSGPYVDGQVLVWHDVLGLYEESPPFVKRYANLRDEIL 240
           EFVLADVAKLVTEEVSIPTIGIGSGPYVDGQVLVWHDVLGLYE SPPF KRYANL++EIL
Sbjct: 181 EFVLADVAKLVTEEVSIPTIGIGSGPYVDGQVLVWHDVLGLYESSPPFAKRYANLKEEIL 240

Query: 241 GAISEFKKDVKEGKFPGREHYWEFQDKEEFKRIKESVLRKVD 282
            AIS F+++VKEGKFPGREHYWEFQDKEEFKRIK++V++K++
Sbjct: 241 RAISTFREEVKEGKFPGREHYWEFQDKEEFKRIKDNVMKKLN 282


>sp|Q9X251|PANB_THEMA 3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE (KETOPANTOATE
           HYDROXYMETHYLTRANSFERASE) >gi|7433451|pir||G72216
           3-methyl-2-oxobutanoate hydroxymethyltransferase -
           Thermotoga maritima (strain MSB8)
           >gi|4982305|gb|AAD36793.1|AE001812_3 (AE001812)
           3-methyl-2-oxobutanoate hydroxymethyltransferase
           [Thermotoga maritima]
           Length = 270
           
 Score =  293 bits (742), Expect = 2e-78
 Identities = 149/263 (56%), Positives = 193/263 (72%), Gaps = 3/263 (1%)

Query: 8   KIIEMKGKEKIAMITAYDYPSALLADKAGFDIVFVGDSLGMVVYGEPNTLNVSMEQMVFH 67
           K+ +MKGKEKI M+TAYD PSA +A  AG D++ VGDSLG  V G  NT+ V+ME+M+ H
Sbjct: 5   KLKKMKGKEKIVMVTAYDAPSARIARDAGIDVILVGDSLGNNVLGYENTIPVTMEEMLIH 64

Query: 68  TRAVARAVKRALVLADMPFGSYEVSVEEGIKNAIKLIQAGADAVKIEGGYDHKKLVKRLV 127
             AV R    A ++ADMPF SY+ SVE+ ++NA K ++ GA+AVKIEGG +  +LV++LV
Sbjct: 65  VAAVKRGAPDAFIVADMPFLSYQTSVEKAVENAGKFLKVGANAVKIEGGEEFGELVQKLV 124

Query: 128 RMGIPVMGHTGLTPQRYLRLGGYRIMGSTEEEVEEIIRDAKALEKAGAFAVVLEFVLADV 187
             GIPVMGH GLTPQ   R GGYR+ G TE+  E ++R A+ LEK GAFA+VLE V+ +V
Sbjct: 125 ESGIPVMGHIGLTPQFVNRFGGYRVQGKTEKNREYLLRSARELEKRGAFAIVLELVVEEV 184

Query: 188 AKLVTEEVSIPTIGIGSGPYVDGQVLVWHDVLGLYEE-SPPFVKRYANLRDEILGAISEF 246
           AK +TE VSIPTIGIGSG + DGQVLVWHD+LGL  + +P F K+YANL + IL A+ EF
Sbjct: 185 AKEITESVSIPTIGIGSGRFCDGQVLVWHDLLGLNPDFAPRFSKKYANLYEVILKALQEF 244

Query: 247 KKDVKEGKFPGREHYWEFQDKEE 269
           +++VK+G FP  EH   F DK +
Sbjct: 245 RREVKKGLFPTEEH--SFTDKSK 265


>gb|AAK42546.1| Ketopantoate hydroxymethyltransferase (panB) [Sulfolobus
           solfataricus]
           Length = 267
           
 Score =  293 bits (741), Expect = 2e-78
 Identities = 142/264 (53%), Positives = 196/264 (73%), Gaps = 1/264 (0%)

Query: 1   MREITPRKIIEMKG-KEKIAMITAYDYPSALLADKAGFDIVFVGDSLGMVVYGEPNTLNV 59
           M+++T R  I+ K  KEKI M+TAYDYP+A +      D + VGDSLGMVV G  NTLNV
Sbjct: 1   MKKVTIRDFIKKKSMKEKITMLTAYDYPTAKIISNTTLDSILVGDSLGMVVLGYTNTLNV 60

Query: 60  SMEQMVFHTRAVARAVKRALVLADMPFGSYEVSVEEGIKNAIKLIQAGADAVKIEGGYDH 119
           +M  M+ HTRAVARA    L+++DMPF SYE+ V+  +KNA  L++AG+DAVK+EGG + 
Sbjct: 61  TMRDMISHTRAVARANPPQLIVSDMPFLSYEIDVKSAVKNAGLLVKAGSDAVKLEGGEEI 120

Query: 120 KKLVKRLVRMGIPVMGHTGLTPQRYLRLGGYRIMGSTEEEVEEIIRDAKALEKAGAFAVV 179
           K +++ +V+ GIPVMGH GLTPQR+LRLGG+R +G T++E E++I+D+  LE AG F++V
Sbjct: 121 KDIIRAIVKAGIPVMGHIGLTPQRFLRLGGFRTIGKTKQEEEQLIKDSLELEDAGVFSIV 180

Query: 180 LEFVLADVAKLVTEEVSIPTIGIGSGPYVDGQVLVWHDVLGLYEESPPFVKRYANLRDEI 239
           +E    D+AK +TE++++PTI IG+GPY DGQVLV HD+LGL E +P F K Y NL++ I
Sbjct: 181 IENTYVDIAKRITEKLNVPTICIGAGPYCDGQVLVIHDLLGLSEVTPYFAKSYVNLKEII 240

Query: 240 LGAISEFKKDVKEGKFPGREHYWE 263
             AI+++  DVK  KFP ++HY E
Sbjct: 241 SSAINQYIIDVKTNKFPEKQHYKE 264


>sp|Q9YE97|PANB_AERPE 3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE (KETOPANTOATE
           HYDROXYMETHYLTRANSFERASE) >gi|7433449|pir||A72656
           probable 3-methyl-2-oxobutanoate hydroxymethyl
           transferase APE0676 - Aeropyrum pernix (strain K1)
           >gi|5104334|dbj|BAA79649.1| (AP000060) 274aa long
           hypothetical 3-methyl-2-oxobutanoate hydroxymethyl
           transferase [Aeropyrum pernix]
           Length = 274
           
 Score =  286 bits (723), Expect = 3e-76
 Identities = 132/258 (51%), Positives = 189/258 (73%)

Query: 3   EITPRKIIEMKGKEKIAMITAYDYPSALLADKAGFDIVFVGDSLGMVVYGEPNTLNVSME 62
           ++T R+I++MKG   I  +TAYDYP+A +AD+AG D++ VGDSLGMVV G P+TL V+++
Sbjct: 5   KVTARRILKMKGSRPIVAVTAYDYPTAWIADEAGVDVILVGDSLGMVVLGYPSTLQVTLD 64

Query: 63  QMVFHTRAVARAVKRALVLADMPFGSYEVSVEEGIKNAIKLIQAGADAVKIEGGYDHKKL 122
            MV HT AVARA KR L++ADMPFGSYE S    +++A+ L + GA+AVK+EGG ++   
Sbjct: 65  DMVRHTAAVARAAKRPLIVADMPFGSYEPSSSAAVESAVALARVGAEAVKLEGGSEYADR 124

Query: 123 VKRLVRMGIPVMGHTGLTPQRYLRLGGYRIMGSTEEEVEEIIRDAKALEKAGAFAVVLEF 182
           VK +V  GIPVMGH GLTPQR +R+GGYR      +E   ++ DA++L +AG F++VLEF
Sbjct: 125 VKAIVDAGIPVMGHLGLTPQRAMRIGGYRPRARGRDEARRLLLDAESLVEAGVFSIVLEF 184

Query: 183 VLADVAKLVTEEVSIPTIGIGSGPYVDGQVLVWHDVLGLYEESPPFVKRYANLRDEILGA 242
           V  + A++VT  V +PTI IGSG   DGQ++V+HD++GL   +PPF K+Y + R  ++ A
Sbjct: 185 VSEEAAEMVTRRVPVPTICIGSGRRCDGQIIVFHDIVGLSRHTPPFAKKYVDARRIMVEA 244

Query: 243 ISEFKKDVKEGKFPGREH 260
           ++ + +DV+ G+FPG EH
Sbjct: 245 VTRYAEDVRNGRFPGEEH 262


>sp|Q9Y7B6|PANB_EMENI 3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE (KETOPANTOATE
           HYDROXYMETHYLTRANSFERASE) >gi|11359354|pir||T50553
           3-methyl-2-oxobutanoate hydroxymethyltransferase (EC
           2.1.2.11) [imported] - Emericella nidulans
           >gi|5001995|gb|AAD37248.1|AF134703_1 (AF134703)
           ketopantoate hydroxymethyltransferase [Aspergillus
           nidulans]
           Length = 349
           
 Score =  232 bits (585), Expect = 4e-60
 Identities = 119/286 (41%), Positives = 187/286 (64%), Gaps = 12/286 (4%)

Query: 3   EITPRKIIEM-------KGKEKIAMITAYDYPSALLADKAGFDIVFVGDSLGMVVYGEPN 55
           +  PRK + M       K  E I M+TA+D+PSA +AD AG D++ VGDSL MV  G  +
Sbjct: 58  QANPRKKVTMQTLRNLYKKGEPITMLTAHDFPSAHVADAAGMDMILVGDSLAMVALGMQD 117

Query: 56  TLNVSMEQMVFHTRAVARAVKRALVLADMPFGSYEVSVEEGIKNAIKLIQAG-ADAVKIE 114
           T  V+++ M+ H R+VARA + A  ++D+P GSYEVS E+ +++AI++++ G    VK+E
Sbjct: 118 TSEVTLDDMLVHCRSVARAAQSAFTVSDLPMGSYEVSPEQALQSAIRIVKEGRVQGVKLE 177

Query: 115 GGYDHKKLVKRLVRMGIPVMGHTGLTPQRYLRLGGYRIMGSTEEEVEEIIRDAKALEKAG 174
           GG +    +KR+   GIPV+GH GLTPQR   LGG+R+ G +  +  ++++DA A+++AG
Sbjct: 178 GGEEMAPAIKRITTAGIPVVGHIGLTPQRQNALGGFRVQGKSTTDALKLLKDALAVQEAG 237

Query: 175 AFAVVLEFVLADVAKLVTEEVSIPTIGIGSGPYVDGQVLVWHDVLGLYEES---PPFVKR 231
           AF +V+E V  ++A +VT+++S+PTIGIG+G    GQVLV  D+ G +      P FVK+
Sbjct: 238 AFMIVIEAVPPEIASIVTQKLSVPTIGIGAGNGCSGQVLVQIDMTGNFPPGRFLPKFVKQ 297

Query: 232 YANLRDEILGAISEFKKDVKEGKFPGREHYWEFQDKEEFKRIKESV 277
           YAN+ +E L  I +++++VK   +P  +H +    KEE    +++V
Sbjct: 298 YANVWNEALQGIQQYREEVKSRAYPAEQHTYPI-PKEELVEFQKAV 342


>sp|O67783|PANB_AQUAE 3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE (KETOPANTOATE
           HYDROXYMETHYLTRANSFERASE) >gi|7433447|pir||C70469
           3-methyl-2-oxobutanoate hydroxymethyltransferase -
           Aquifex aeolicus >gi|2984220|gb|AAC07749.1| (AE000766)
           3-methyl-2-oxobutanoate hydroxymethyltransferase
           [Aquifex aeolicus]
           Length = 265
           
 Score =  231 bits (582), Expect = 9e-60
 Identities = 119/246 (48%), Positives = 171/246 (69%), Gaps = 2/246 (0%)

Query: 16  EKIAMITAYDYPSALLADKAGFDIVFVGDSLGMVVYGEPNTLNVSMEQMVFHTRAVARAV 75
           +KI M++ YDY SA L D+ G D + VGDSLG VV GE +TL+V++E++++HT+ V R V
Sbjct: 16  KKITMVSTYDYWSAKLCDEVGIDCILVGDSLGTVVKGEGDTLSVTLEEIIYHTKCVMRGV 75

Query: 76  KRALVLADMPFGSYEVSVEEGIKNAIKLI-QAGADAVKIEGGYDHKKLVKRLVRMGIPVM 134
           K A V+ADMPF SY+VS+E+ ++N  ++I +  A AVK+EGG +  +LV +L R+GIPV+
Sbjct: 76  KNAFVIADMPFMSYQVSMEKAVENCGRVIKETKAKAVKLEGGEEIAELVYKLTRIGIPVV 135

Query: 135 GHTGLTPQRYLRLGGYRIMGSTEEEVEEIIRDAKALEKAGAFAVVLEFVLADVAKLVTEE 194
           GH G TPQ     G  +++G  +EE E++ RD +ALE+AGAF +VLE V   +AK + + 
Sbjct: 136 GHVGFTPQHINVFGKPKVVGKKKEEEEKLRRDFRALEEAGAFMIVLESVPTHLAKELWKG 195

Query: 195 VSIPTIGIGSGPYVDGQVLVWHDVLGLYEE-SPPFVKRYANLRDEILGAISEFKKDVKEG 253
            +   IGIG+G YVDGQVLV+HD++GL+E+  P FV+RY      +  A+  FK DV+ G
Sbjct: 196 SNSIVIGIGAGKYVDGQVLVFHDIVGLFEDFKPKFVRRYLEGAKLVKEALKNFKIDVEGG 255

Query: 254 KFPGRE 259
            FP  E
Sbjct: 256 NFPSEE 261


>dbj|BAB05406.1| (AP001512) ketopantoate hydroxymethyltransferase [Bacillus
           halodurans]
           Length = 279
           
 Score =  227 bits (572), Expect = 1e-58
 Identities = 116/254 (45%), Positives = 168/254 (65%), Gaps = 2/254 (0%)

Query: 15  KEKIAMITAYDYPSALLADKAGFDIVFVGDSLGMVVYGEPNTLNVSMEQMVFHTRAVARA 74
           KEKIAM+TAYD PSA L + A  D++ VGDSLGMVV G  +T+ V+++ M+ HT+AV R 
Sbjct: 14  KEKIAMMTAYDAPSARLVEDADVDMILVGDSLGMVVLGYDSTIPVTLDDMIHHTKAVKRG 73

Query: 75  VKRALVLADMPFGSYEVSVEEGIKNAIKLIQ-AGADAVKIEGGYDHKKLVKRLVRMGIPV 133
            K   ++ DMP+ +Y  S  E +  A +L+Q AGADA+K+EG  D    ++RL   G+P+
Sbjct: 74  AKNTFIVTDMPYLTYHGSFNETLVGAKRLMQEAGADALKLEGNGDIIDTIERLTLAGVPI 133

Query: 134 MGHTGLTPQRYLRLGGYRIMGSTEEEVEEIIRDAKALEKAGAFAVVLEFVLADVAKLVTE 193
           + H GLTPQ     GGYR+     +  ++++ DAKA+E AGAFA+VLE V   VA  ++E
Sbjct: 134 VAHLGLTPQNVAVEGGYRVQAKDAKSAKQLLADAKAVEAAGAFALVLECVPEQVATQISE 193

Query: 194 EVSIPTIGIGSGPYVDGQVLVWHDVLGL-YEESPPFVKRYANLRDEILGAISEFKKDVKE 252
           E++IP IGIG+G   DGQVLV+HDV+G      P FVK+Y N+   I  A+ ++ ++VK 
Sbjct: 194 ELTIPVIGIGAGAGCDGQVLVYHDVIGYGAGHVPSFVKQYVNITKPIEEAMKQYVQEVKA 253

Query: 253 GKFPGREHYWEFQD 266
           G FP ++H +  ++
Sbjct: 254 GTFPDKDHAFSLKE 267


>pir||T47945 3-methyl-2-oxobutanoate hydroxy-methyl-transferase-like protein -
           Arabidopsis thaliana >gi|6850844|emb|CAB71083.1|
           (AL132962) 3-methyl-2-oxobutanoate
           hydroxy-methyl-transferase-like protein [Arabidopsis
           thaliana]
           Length = 354
           
 Score =  226 bits (569), Expect = 3e-58
 Identities = 116/253 (45%), Positives = 163/253 (63%), Gaps = 8/253 (3%)

Query: 16  EKIAMITAYDYPSALLADKAGFDIVFVGDSLGMVVYGEPNTLNVSMEQMVFHTRAVARAV 75
           E I M+TAYDYPSA+  D AG D+  VGDS  MVV+G   TL +S+E+M+ H RAVAR  
Sbjct: 57  EPITMVTAYDYPSAVHIDTAGIDVCLVGDSAAMVVHGYDTTLPISLEEMLVHCRAVARGA 116

Query: 76  KRALVLADMPFGSYEVSVEEGIKNAIKLI-QAGADAVKIEGGYDHK-KLVKRLVRMGIPV 133
           KR L++ D+PFG+YE S  + +  A++++ + G DA+K+EGG   +    K +V  GI V
Sbjct: 117 KRPLLVGDLPFGTYESSTNQAVDTAVRVLKEGGMDAIKLEGGSPSRITAAKSIVEAGIAV 176

Query: 134 MGHTGLTPQRYLRLGGYRIMGSTEEEVEEIIRDAKALEKAGAFAVVLEFVLADVAKLVTE 193
           MGH GLTPQ    LGG+R  G       +++  A AL++AG F+VVLE V   VA   T 
Sbjct: 177 MGHVGLTPQAISVLGGFRPQGKNIASAVKVVETAMALQEAGCFSVVLECVPPPVAAAATS 236

Query: 194 EVSIPTIGIGSGPYVDGQVLVWHDVLGLYEE------SPPFVKRYANLRDEILGAISEFK 247
            ++IPTIGIG+GP+  GQVLV+HD+LG+ +       +P F K+YA + + I  A+ E+K
Sbjct: 237 ALNIPTIGIGAGPFCSGQVLVYHDLLGMMQHPHHAKVTPKFCKQYAQVGEVINKALLEYK 296

Query: 248 KDVKEGKFPGREH 260
           ++V +  FPG  H
Sbjct: 297 EEVSKHLFPGPSH 309


>sp|P52996|PANB_BACSU 3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE (KETOPANTOATE
           HYDROXYMETHYLTRANSFERASE) >gi|7433446|pir||G69671
           ketopantoate hydroxymethyltransferase panB - Bacillus
           subtilis >gi|1146240|gb|AAB38448.1| (L47709)
           ketopantoate hydroxymethyltransferase [Bacillus
           subtilis] >gi|2634661|emb|CAB14159.1| (Z99115)
           ketopantoate hydroxymethyltransferase [Bacillus
           subtilis]
           Length = 277
           
 Score =  226 bits (569), Expect = 3e-58
 Identities = 117/262 (44%), Positives = 174/262 (65%), Gaps = 3/262 (1%)

Query: 5   TPRKIIEMK-GKEKIAMITAYDYPSALLADKAGFDIVFVGDSLGMVVYGEPNTLNVSMEQ 63
           T    ++MK  +E I M+TAYDYP+A LA++AG D++ VGDSLGMVV G  +T+ V++  
Sbjct: 3   TKLDFLKMKESEEPIVMLTAYDYPAAKLAEQAGVDMILVGDSLGMVVLGLDSTVGVTVAD 62

Query: 64  MVFHTRAVARAVKRALVLADMPFGSYEVSVEEGIKNAIKLIQ-AGADAVKIEGGYDHKKL 122
           M+ HT+AV R      ++ DMPF SY +S E+ +KNA  ++Q +GADA+K+EGG    + 
Sbjct: 63  MIHHTKAVKRGAPNTFIVTDMPFMSYHLSKEDTLKNAAAIVQESGADALKLEGGEGVFES 122

Query: 123 VKRLVRMGIPVMGHTGLTPQRYLRLGGYRIMGSTEEEVEEIIRDAKALEKAGAFAVVLEF 182
           ++ L   GIPV+ H GLTPQ    LGGY++ G  E+  +++I D+   E+AGA  +VLE 
Sbjct: 123 IRALTLGGIPVVSHLGLTPQSVGVLGGYKVQGKDEQSAKKLIEDSIKCEEAGAMMLVLEC 182

Query: 183 VLADVAKLVTEEVSIPTIGIGSGPYVDGQVLVWHDVLGL-YEESPPFVKRYANLRDEILG 241
           V A++   + E +SIP IGIG+G   DGQVLV+HD++G   E +P FVK+Y  + + I  
Sbjct: 183 VPAELTAKIAETLSIPVIGIGAGVKADGQVLVYHDIIGHGVERTPKFVKQYTRIDETIET 242

Query: 242 AISEFKKDVKEGKFPGREHYWE 263
           AIS + +DV+   FP ++H ++
Sbjct: 243 AISGYVQDVRHRAFPEQKHSFQ 264


>pir||F81448 3-methyl-2-oxobutanoate hydroxymethyltransferase (EC 2.1.2.11)
           Cj0298c [imported] - Campylobacter jejuni (strain NCTC
           11168) >gi|6967772|emb|CAB72765.1| (AL139074)
           3-methyl-2-oxobutanoate hydroxymethyltransferase
           [Campylobacter jejuni]
           Length = 274
           
 Score =  224 bits (566), Expect = 7e-58
 Identities = 118/262 (45%), Positives = 175/262 (66%), Gaps = 5/262 (1%)

Query: 10  IEMKGK-EKIAMITAYDYPSALLADKAGFDIVFVGDSLGMVVYGEPNTLNVSMEQMVFHT 68
           +E K K EKI M++AYDY SA + D +  DI+ VGDSL M V G  +TL+V+M++M+  T
Sbjct: 9   LEKKAKNEKITMVSAYDYHSARILDNSDIDIILVGDSLAMTVLGMQDTLSVTMDEMLIFT 68

Query: 69  RAVARAVKRALVLADMPFGSYEVSVEEGIKNAIKLI-QAGADAVKIEGGYDHKKLVKRLV 127
           +AV+R  K++ VLADMPF SY+ S  + I NA + I ++ A+ VK+EGG +    +K + 
Sbjct: 69  KAVSRGAKKSFVLADMPFMSYQSSDRDAILNASRFIKESHANGVKVEGGIEIASKIKLIS 128

Query: 128 RMGIPVMGHTGLTPQRYLRLGGYRIMGSTEEEVEEIIRDAKALEKAGAFAVVLEFVLADV 187
           + GIPV+ H GLTPQ    LGGYR+ G   +  ++II DAKA++ AGA  +VLE V   +
Sbjct: 129 QSGIPVVAHLGLTPQAVNMLGGYRVQGKDLQSAQKIIDDAKAVQDAGACMLVLECVPVKL 188

Query: 188 AKLVTEEVSIPTIGIGSGPYVDGQVLVWHDVLGLYEE-SPPFVKRYANLRDEILGAISEF 246
           A+ ++  + IPTIGIGSG Y DGQVLV+HD+LGL ++    FVK +  +  ++   + ++
Sbjct: 189 AQKISSILEIPTIGIGSGKYCDGQVLVYHDLLGLNKDFKAKFVKHFDKIDPQV--GVEKY 246

Query: 247 KKDVKEGKFPGREHYWEFQDKE 268
           + +VK G FP +EH +++ D E
Sbjct: 247 RDEVKSGIFPSQEHSFDYLDDE 268


>gb|AAC62893.1| (AC005397) 3-methyl-2-oxobutanoate hydroxy-methyl-transferase
           [Arabidopsis thaliana]
           Length = 347
           
 Score =  223 bits (562), Expect = 2e-57
 Identities = 114/253 (45%), Positives = 163/253 (64%), Gaps = 8/253 (3%)

Query: 16  EKIAMITAYDYPSALLADKAGFDIVFVGDSLGMVVYGEPNTLNVSMEQMVFHTRAVARAV 75
           E I ++TAYDYPSA+  D AG D+  VGDS  MVV+G   TL +S+++M+ H RAVAR  
Sbjct: 55  EPITVVTAYDYPSAVHLDTAGIDVCLVGDSASMVVHGHDTTLPISLDEMLVHCRAVARGA 114

Query: 76  KRALVLADMPFGSYEVSVEEGIKNAIKLI-QAGADAVKIEGGYDHK-KLVKRLVRMGIPV 133
           KR L++ D+PFG+YE S  + +  A++++ + G DA+K+EGG   +    K +V  GI V
Sbjct: 115 KRPLLVGDLPFGTYESSSSQAVDTAVRVLKEGGMDAIKLEGGSASRITAAKAIVEAGIAV 174

Query: 134 MGHTGLTPQRYLRLGGYRIMGSTEEEVEEIIRDAKALEKAGAFAVVLEFVLADVAKLVTE 193
           +GH GLTPQ    LGG+R  G       +++  A AL++AG F+VVLE V   VA   T 
Sbjct: 175 IGHVGLTPQAISVLGGFRPQGRNIASAVKVVETAMALQEAGCFSVVLECVPPPVAAAATS 234

Query: 194 EVSIPTIGIGSGPYVDGQVLVWHDVLGLYEE------SPPFVKRYANLRDEILGAISEFK 247
            + IPTIGIG+GP+  GQVLV+HD+LG+ +       +P F K+YAN+ + I  A+ E+K
Sbjct: 235 ALKIPTIGIGAGPFCSGQVLVYHDLLGMMQHPHHAKVTPKFCKQYANVGEVINKALMEYK 294

Query: 248 KDVKEGKFPGREH 260
           ++V +  FPG  H
Sbjct: 295 EEVSKKVFPGPSH 307


>pir||C83447 conserved hypothetical protein PA1598 [imported] - Pseudomonas
           aeruginosa (strain PAO1)
           >gi|9947562|gb|AAG04987.1|AE004587_11 (AE004587)
           conserved hypothetical protein [Pseudomonas aeruginosa]
           Length = 273
           
 Score =  222 bits (561), Expect = 3e-57
 Identities = 121/256 (47%), Positives = 167/256 (64%), Gaps = 3/256 (1%)

Query: 13  KGKEKIAMITAYDYPSALLADKAGFDIVFVGDSLGMVVYGEPNTLNVSMEQMVFHTRAVA 72
           KG   +  +TAY  P A L D    D++ VGDSLGMV+YG P+TL VS+E MV HT AV 
Sbjct: 19  KGAGSLVALTAYSTPMARLLDPHA-DLLLVGDSLGMVLYGMPSTLGVSLEMMVAHTLAVM 77

Query: 73  RAVKRALVLADMPFGSYEVSVEEGIKNAIKLI-QAGADAVKIEGGYDHKKLVKRLVRMGI 131
           R  +RA V+AD+PF SY+ S  +  +NA +L+  +GA AVK+EGG + ++ V  LVR GI
Sbjct: 78  RGSRRACVVADLPFASYQESPRQAFRNAARLLADSGAQAVKLEGGEEMEETVDFLVRRGI 137

Query: 132 PVMGHTGLTPQRYLRLGGYRIMGSTEEEVEEIIRDAKALEKAGAFAVVLEFVLADVAKLV 191
           PV+ H GL PQ+   +GG++  G   E  E + RD  A+++ GAFAVV+E V   +A+ +
Sbjct: 138 PVLAHIGLMPQQVNAMGGFKAQGRDPESAERVRRDGLAMQRGGAFAVVIEGVGEPLARRL 197

Query: 192 TEEVSIPTIGIGSGPYVDGQVLVWHDVLGLY-EESPPFVKRYANLRDEILGAISEFKKDV 250
           +EE++IP IGIG+ P  DGQVLV  D+LGL  E+ P FV+RYA L  EI  A   F +DV
Sbjct: 198 SEELAIPCIGIGASPACDGQVLVSEDLLGLSGEQVPRFVERYARLDREIDEAARRFAEDV 257

Query: 251 KEGKFPGREHYWEFQD 266
           +E +FP   H +  ++
Sbjct: 258 RERRFPEARHCFAMRE 273


>sp|Q9X712|PANB_CORGL 3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE (KETOPANTOATE
           HYDROXYMETHYLTRANSFERASE) >gi|11256690|pir||T47119
           3-methyl-2-oxobutanoate hydroxymethyltransferase (EC
           2.1.2.11) [validated] - Corynebacterium glutamicum
           >gi|4803658|emb|CAA65397.1| (X96580)
           3-methyl-2-oxobutanoate hydroxymethyltransferase
           [Corynebacterium glutamicum]
           Length = 271
           
 Score =  219 bits (552), Expect = 3e-56
 Identities = 119/259 (45%), Positives = 172/259 (65%), Gaps = 4/259 (1%)

Query: 2   REITPRKIIEMK-GKEKIAMITAYDYPSALLADKAGFDIVFVGDSLGMVVYGEPNTLNVS 60
           ++I  R   E K   +K++++T+YD  SA + D+AG D++ VGDS   VV G   TL+++
Sbjct: 9   KKIRTRHFREAKVNGQKVSVLTSYDALSARIFDEAGVDMLLVGDSAANVVLGRDTTLSIT 68

Query: 61  MEQMVFHTRAVARAVKRALVLADMPFGSYEVSVEEGIKNAIKLI-QAGADAVKIEGGYDH 119
           +++M+   +AV  A KRALV+ D+PFG+YEVS  + +++AI+++ + GA AVKIEGG + 
Sbjct: 69  LDEMIVLAKAVTIATKRALVVVDLPFGTYEVSPNQAVESAIRVMRETGAAAVKIEGGVEI 128

Query: 120 KKLVKRLVRMGIPVMGHTGLTPQRYLRLGGYRIMGSTEEEVEEIIRDAKALEKAGAFAVV 179
            + ++R+V  GIPV+GH G TPQ    LGG+ + G       ++I DA+ALE+AGAFAVV
Sbjct: 129 AQTIRRIVDAGIPVVGHIGYTPQSEHSLGGHVVQGRGASS-GKLIADARALEQAGAFAVV 187

Query: 180 LEFVLADVAKLVTEEVSIPTIGIGSGPYVDGQVLVWHDVLGLYE-ESPPFVKRYANLRDE 238
           LE V A+ A+ VTE++SI TIGIG+G   DGQVLVW D  GL   + P FV+ YA L D 
Sbjct: 188 LEMVPAEAAREVTEDLSITTIGIGAGNGTDGQVLVWQDAFGLNRGKKPRFVREYATLGDS 247

Query: 239 ILGAISEFKKDVKEGKFPG 257
           +  A   +  D+  G FPG
Sbjct: 248 LHDAAQAYIADIHAGTFPG 266


>sp|P52997|PANB_SYNY3 3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE (KETOPANTOATE
           HYDROXYMETHYLTRANSFERASE) >gi|7433443|pir||S75966
           3-methyl-2-oxobutanoate hydroxymethyltransferase (EC
           2.1.2.11) - Synechocystis sp. (strain PCC 6803)
           >gi|1001326|dbj|BAA10813.1| (D64006) alpha-ketopantoate
           hydroxymethyl transferase [Synechocystis sp.]
           Length = 260
           
 Score =  218 bits (550), Expect = 5e-56
 Identities = 119/258 (46%), Positives = 170/258 (65%), Gaps = 4/258 (1%)

Query: 4   ITPRKIIEMKGKEK-IAMITAYDYPSALLADKAGFDIVFVGDSLGMVVYGEPNTLNVSME 62
           ITP ++++ K +++ I  +TA+D   A + D AG +I+ VGDSLGMV  G   TL VS++
Sbjct: 3   ITPTQLLDWKRQQRPIVALTAWDTAIASVLDAAGVEIILVGDSLGMVALGYETTLPVSLD 62

Query: 63  QMVFHTRAVARAVKRALVLADMPFGSYEVSVEEGIKNAIKLIQ-AGADAVKIEGGYDHK- 120
            M+ HT AV R V+RALV+ D+PF +Y+ S  + + +A +++Q  GA AVK+EGG+    
Sbjct: 63  TMIHHTAAVKRGVQRALVVCDLPFLTYQESPAQAMGSAGRVLQETGAQAVKLEGGHPRMV 122

Query: 121 KLVKRLVRMGIPVMGHTGLTPQRYLRLGGYRIMGSTEEEVEEIIRDAKALEKAGAFAVVL 180
           + V RL  +GIPVMGH GLTPQ   +LG YR  G      E+I+  A AL +AG FA+VL
Sbjct: 123 ETVARLTEVGIPVMGHVGLTPQSVHQLG-YRQQGQDPATAEKILHQAIALAEAGVFAIVL 181

Query: 181 EFVLADVAKLVTEEVSIPTIGIGSGPYVDGQVLVWHDVLGLYEESPPFVKRYANLRDEIL 240
           E + +++A  +TE++ IPTIGIG+GP  DGQVLV  D+LGL  + PPF   Y NLR  I 
Sbjct: 182 EHIPSELAASITEQLPIPTIGIGAGPQCDGQVLVTADLLGLTVKQPPFAPAYLNLRHTIT 241

Query: 241 GAISEFKKDVKEGKFPGR 258
             + +F  +V++ +FP R
Sbjct: 242 ETVHKFSGEVRQRQFPRR 259


>pir||E75253 3-methyl-2-oxobutanoate hydroxymethyltransferase - Deinococcus
           radiodurans (strain R1)
           >gi|6460442|gb|AAF12151.1|AE002090_7 (AE002090)
           3-methyl-2-oxobutanoate hydroxymethyltransferase
           [Deinococcus radiodurans]
           Length = 293
           
 Score =  216 bits (545), Expect = 2e-55
 Identities = 111/253 (43%), Positives = 165/253 (64%), Gaps = 3/253 (1%)

Query: 18  IAMITAYDYPSALLADKAGFDIVFVGDSLGMVVYGEPNTLNVSMEQMVFHTRAVARAVKR 77
           + M+TAYDYP A  A+ AG D++ VGDSLG VV G  +T  V++  M+ H +AV R    
Sbjct: 35  LVMVTAYDYPGARHAEAAGVDLILVGDSLGNVVLGYDSTAPVTLADMIHHGKAVRRGAPN 94

Query: 78  ALVLADMPFGSYEVSVEEGIKNAIKLIQ-AGADAVKIEGGYDHK-KLVKRLVRMGIPVMG 135
             ++ D+PFG+Y   V + +++A+++IQ  GADAVK+EG       +V+ L R G+PVMG
Sbjct: 95  TFLVVDLPFGTYHAGVTDAMRHAVRVIQETGADAVKMEGSTPEVLDVVRVLSRNGVPVMG 154

Query: 136 HTGLTPQRYLRLGGYRIMGSTEEEVEEIIRDAKALEKAGAFAVVLEFVLADVAKLVTEEV 195
           H GL PQ     GG R+ G  ++     +  A AL++AGAFAVVLE + A +A+L++E +
Sbjct: 155 HVGLMPQTAAAQGGLRVQGKDDDSARRTLEGAVALQEAGAFAVVLEAIPARLARLISERL 214

Query: 196 SIPTIGIGSGPYVDGQVLVWHDVLGLYE-ESPPFVKRYANLRDEILGAISEFKKDVKEGK 254
           S+ TIGIG+G + DGQVLV+HD+LGLYE E     KRYA+L  E   AI+ +  +V+  +
Sbjct: 215 SVATIGIGAGVHCDGQVLVYHDLLGLYEGEEKKIAKRYADLGREAREAIAHYAAEVRARE 274

Query: 255 FPGREHYWEFQDK 267
           FP +++ +  +D+
Sbjct: 275 FPSKDNSFVMKDE 287


>pir||T50565 3-methyl-2-oxobutanoate hydroxymethyltransferase (EC 2.1.2.11)
           [imported] - Streptomyces coelicolor
           >gi|6469241|emb|CAB61702.1| (AL133220)
           3-methyl-2-oxobutanoate hydroxymethyltransferase (EC
           2.1.2.11). [Streptomyces coelicolor A3(2)]
           Length = 291
           
 Score =  215 bits (541), Expect = 6e-55
 Identities = 119/262 (45%), Positives = 167/262 (63%), Gaps = 4/262 (1%)

Query: 2   REITPRKIIEMKGK-EKIAMITAYDYPSALLADKAGFDIVFVGDSLGMVVYGEPNTLNVS 60
           R IT R I   K + EK  M+TAYD  +A + D++G  ++ VGDS G    G   T+ V+
Sbjct: 28  RRITVRDITAAKERGEKWPMLTAYDAMTASVFDESGIPVMLVGDSAGNCHLGYETTVPVT 87

Query: 61  MEQMVFHTRAVARAVKRALVLADMPFGSYEVSVEEGIKNAIKLI-QAGADAVKIEGGYDH 119
           +++M   + AV R   RAL++ D+PFGSY+    + +++A +L+ +AG  AVK+EGG   
Sbjct: 88  LDEMTMLSAAVVRGTSRALIVGDLPFGSYQEGPVQALRSATRLVKEAGVGAVKLEGGERS 147

Query: 120 KKLVKRLVRMGIPVMGHTGLTPQRYLRLGGYRIMGSTEEEVEEIIRDAKALEKAGAFAVV 179
            + ++ LV  GIPVM H GLTPQ    +G YR+ G  EE  ++++RDAKA++ AGAFAVV
Sbjct: 148 HRQIELLVESGIPVMAHIGLTPQSVNSMG-YRVQGRGEEAAQQLLRDAKAVQDAGAFAVV 206

Query: 180 LEFVLADVAKLVTEEVSIPTIGIGSGPYVDGQVLVWHDVLGLY-EESPPFVKRYANLRDE 238
           LE V A++A  VT  + IPT+GIG+GP  D QVLVW D+LGL     P FVK+YA+LR  
Sbjct: 207 LELVPAELAAEVTRTLHIPTVGIGAGPDTDAQVLVWTDMLGLTGGRMPKFVKQYADLRKV 266

Query: 239 ILGAISEFKKDVKEGKFPGREH 260
           +  A   + +DV  G FP  EH
Sbjct: 267 MGDAAKAYAEDVVGGTFPADEH 288


>pir||F81148 3-methyl-2-oxobutanoate hydroxymethyltransferase NMB0870 [imported]
           - Neisseria meningitidis (group B strain MD58)
           >gi|7226107|gb|AAF41281.1| (AE002439)
           3-methyl-2-oxobutanoate hydroxymethyltransferase
           [Neisseria meningitidis MC58]
           Length = 263
           
 Score =  215 bits (541), Expect = 6e-55
 Identities = 117/259 (45%), Positives = 162/259 (62%), Gaps = 3/259 (1%)

Query: 4   ITPRKIIEMKGK-EKIAMITAYDYPSALLADKAGFDIVFVGDSLGMVVYGEPNTLNVSME 62
           IT   + +MK   EKIAM+TAY+   A L D AG +++ VGDSLGM V G  +TL VS+ 
Sbjct: 2   ITVNTLQKMKAAGEKIAMLTAYESSFAALMDDAGVEMLLVGDSLGMAVQGRKSTLPVSLR 61

Query: 63  QMVFHTRAVARAVKRALVLADMPFGSYEVSVEEGIKNAIKLIQAGADAVKIEGGYDHKKL 122
            M +HT  VAR  K A++++D+PFG+Y+ S E+    A +L+ AGA  VK+EGG    + 
Sbjct: 62  DMCYHTECVARGAKNAMIVSDLPFGAYQQSKEQAFAAAAELMAAGAHMVKLEGGVWMAET 121

Query: 123 VKRLVRMGIPVMGHTGLTPQRYLRLGGYRIMGSTEEEVEEIIRDAKALEKAGAFAVVLEF 182
            + L   GIPV  H GLTPQ     GGY++ G    + + ++ DAKA + AGA  V++E 
Sbjct: 122 TEFLQMRGIPVCAHIGLTPQSVFAFGGYKVQG-RGGKAQALLNDAKAHDDAGAAVVLMEC 180

Query: 183 VLADVAKLVTEEVSIPTIGIGSGPYVDGQVLVWHDVLGLYE-ESPPFVKRYANLRDEILG 241
           VLA++AK VTE VS PTIGIG+G   DGQVLV HD+LG++  ++  FVK +    D +  
Sbjct: 181 VLAELAKKVTETVSCPTIGIGAGADCDGQVLVMHDMLGIFPGKTAKFVKNFMQGHDSVQA 240

Query: 242 AISEFKKDVKEGKFPGREH 260
           A+  +  +VK   FP  EH
Sbjct: 241 AVRAYVAEVKAKTFPAAEH 259


>pir||E81874 probable 3-methyl-2-oxobutanoate hydroxymethyltransferase  (EC
           2.1.2.11) NMA1088 [imported] - Neisseria meningitidis
           (group A strain Z2491) >gi|7379783|emb|CAB84351.1|
           (AL162755) putative 3-methyl-2-oxobutanoate
           hydroxymethyltransferase [Neisseria meningitidis Z2491]
           Length = 263
           
 Score =  213 bits (536), Expect = 2e-54
 Identities = 117/259 (45%), Positives = 161/259 (61%), Gaps = 3/259 (1%)

Query: 4   ITPRKIIEMKGK-EKIAMITAYDYPSALLADKAGFDIVFVGDSLGMVVYGEPNTLNVSME 62
           IT   + +MK   EKIAM+TAY+   A L D AG D++ VGDSLGM V G  +TL VS+ 
Sbjct: 2   ITVNTLQKMKAAGEKIAMLTAYESSFAALMDDAGVDVLLVGDSLGMAVQGRQSTLPVSLR 61

Query: 63  QMVFHTRAVARAVKRALVLADMPFGSYEVSVEEGIKNAIKLIQAGADAVKIEGGYDHKKL 122
            M +HT  VAR  K A++++D+PFG+Y+ S E+    A +L+ AGA  VK+EGG    + 
Sbjct: 62  DMCYHTECVARGAKNAMIVSDLPFGAYQQSKEQAFAAAAELMAAGAHMVKLEGGVWMAET 121

Query: 123 VKRLVRMGIPVMGHTGLTPQRYLRLGGYRIMGSTEEEVEEIIRDAKALEKAGAFAVVLEF 182
            + L   GIPV  H GLTPQ     GGY++ G    + + ++ DAKA + AGA  V++E 
Sbjct: 122 TEFLQMRGIPVCAHIGLTPQSVFAFGGYKVQG-RGGKAQALLNDAKAHDDAGAAVVLMEC 180

Query: 183 VLADVAKLVTEEVSIPTIGIGSGPYVDGQVLVWHDVLGLYE-ESPPFVKRYANLRDEILG 241
           V A++AK VTE VS PTIGIG+G   DGQVLV HD+LG++  ++  FVK +   +  I  
Sbjct: 181 VPAELAKKVTESVSCPTIGIGAGVDCDGQVLVMHDMLGIFPGKTAKFVKNFMQGQSSIQA 240

Query: 242 AISEFKKDVKEGKFPGREH 260
           A+  +  +VK   FP  EH
Sbjct: 241 AVRAYVAEVKAKTFPAAEH 259


>gb|AAG19781.1| (AE005063) ketopantoate hydroxymethyltransferase-like; PanB
           [Halobacterium sp. NRC-1]
           Length = 274
           
 Score =  212 bits (535), Expect = 3e-54
 Identities = 111/246 (45%), Positives = 159/246 (64%), Gaps = 1/246 (0%)

Query: 16  EKIAMITAYDYPSALLADKAGFDIVFVGDSLGMVVYGEPNTLNVSMEQMVFHTRAVARAV 75
           + + M+TAYD P+A + D AG D++ VGDS+G    G   TL VS++++   T AVARA 
Sbjct: 18  DPVTMLTAYDAPTASVVDDAGVDMILVGDSVGNAKLGYDTTLPVSVDEIASATGAVARAT 77

Query: 76  KRALVLADMPFGSYEVSVEEGIKNAIKLI-QAGADAVKIEGGYDHKKLVKRLVRMGIPVM 134
             A+V+ADMPF S+     E ++NA +++ +  ADAVK+E G     L + L  +GIPVM
Sbjct: 78  ADAVVVADMPFLSFGADETESVRNAGRMLKEEDADAVKLESGPHTVSLTETLTSLGIPVM 137

Query: 135 GHTGLTPQRYLRLGGYRIMGSTEEEVEEIIRDAKALEKAGAFAVVLEFVLADVAKLVTEE 194
            H GLTPQ   +LGGY   G+ ++  E ++  A+  E AGAFA+VLE V A+VA  +T+ 
Sbjct: 138 AHLGLTPQHVNQLGGYFRQGTDQDSAERMLDLARDHEAAGAFALVLEHVPANVAADITDA 197

Query: 195 VSIPTIGIGSGPYVDGQVLVWHDVLGLYEESPPFVKRYANLRDEILGAISEFKKDVKEGK 254
           + IPTIGIG+GP  DGQVLV  DV+G+ E SPPF K++ ++  E+  A+ ++   V+ G 
Sbjct: 198 IDIPTIGIGAGPDTDGQVLVISDVIGMSERSPPFSKQFGDVNREMAAAVDDYVDAVESGS 257

Query: 255 FPGREH 260
           FP  EH
Sbjct: 258 FPAAEH 263


>sp|O25698|PANB_HELPY 3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE (KETOPANTOATE
           HYDROXYMETHYLTRANSFERASE) >gi|7433445|pir||B64652
           3-methyl-2-oxobutanoate hydroxymethyltransferase -
           Helicobacter pylori (strain 26695)
           >gi|2314202|gb|AAD08099.1| (AE000613)
           3-methyl-2-oxobutanoate hydroxymethyltransferase (panB)
           [Helicobacter pylori 26695]
           Length = 270
           
 Score =  208 bits (523), Expect = 8e-53
 Identities = 111/259 (42%), Positives = 168/259 (64%), Gaps = 6/259 (2%)

Query: 1   MREITPRKIIEMKGKEKIAMITAYDYPSALLADKAGFDIVFVGDSLGMVVYGEPNTLNVS 60
           +++IT   +   K +EKI  ITAYD   A + D    D++ VGDSL M  + + +TL+ S
Sbjct: 8   IKKITLNHLQAKKNQEKIIAITAYDALFAQIFDPL-VDVILVGDSLNMSFFNQNDTLSAS 66

Query: 61  MEQMVFHTRAVARAVKRALVLADMPFGSYEVSVEEGIKNAIKLI-QAGADAVKIEGGYDH 119
           +E M++HT+AV    K   ++ DMPFGSY+   +  +KNAI++  +  A A+K+EGG + 
Sbjct: 67  VEMMLYHTKAVCAGAKTPFIITDMPFGSYK-DEKTALKNAIRVYKETQASAIKLEGGKEK 125

Query: 120 KKLVKRLVRMGIPVMGHTGLTPQRYLRL-GGYRIMGSTEEEVEEIIRDAKALEKAGAFAV 178
            KLVK L   G+ V+GH GL PQ ++RL GGY+I G  EE+ ++++ DA +LE+AG   +
Sbjct: 126 AKLVKTLTNEGVIVVGHIGLMPQ-FVRLDGGYKIKGKNEEQQKKLLEDALSLEEAGVGLL 184

Query: 179 VLEFVLADVAKLVTEEVSIPTIGIGSGPYVDGQVLVWHDVLGLYEE-SPPFVKRYANLRD 237
           VLE +   +A+ +T+++ IPTIGIGSG   DGQ+LVW D+LG ++   P FV+ Y   ++
Sbjct: 185 VLEGITTPIAQKITQKIKIPTIGIGSGKDCDGQILVWSDMLGFFDSFKPKFVREYLKGKE 244

Query: 238 EILGAISEFKKDVKEGKFP 256
            I  AI ++  DVK+G FP
Sbjct: 245 LIQNAIKQYADDVKKGNFP 263


>sp|Q9ZM56|PANB_HELPJ 3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE (KETOPANTOATE
           HYDROXYMETHYLTRANSFERASE) >gi|7433444|pir||G71942
           3-methyl-2-oxobutanoate hydroxymethyltransferase -
           Helicobacter pylori (strain J99)
           >gi|4154887|gb|AAD05937.1| (AE001471)
           3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE
           [Helicobacter pylori J99]
           Length = 270
           
 Score =  205 bits (517), Expect = 4e-52
 Identities = 110/259 (42%), Positives = 168/259 (64%), Gaps = 6/259 (2%)

Query: 1   MREITPRKIIEMKGKEKIAMITAYDYPSALLADKAGFDIVFVGDSLGMVVYGEPNTLNVS 60
           +++IT   +   K +EKI  ITAYD   A + D    D++ VGDSL M  + + +TL+ S
Sbjct: 8   IKKITLSHLQAKKNQEKIIAITAYDALFAQIFDPL-VDVILVGDSLNMSFFNQNDTLSAS 66

Query: 61  MEQMVFHTRAVARAVKRALVLADMPFGSYEVSVEEGIKNAIKLI-QAGADAVKIEGGYDH 119
           ++ M++HT+AV    K   ++ DMPFGSY+   +  +KNAI++  +  A A+K+EGG + 
Sbjct: 67  VKMMLYHTKAVCAGAKTPFIITDMPFGSYK-DEKTALKNAIRVYKETQASAIKLEGGKEK 125

Query: 120 KKLVKRLVRMGIPVMGHTGLTPQRYLRL-GGYRIMGSTEEEVEEIIRDAKALEKAGAFAV 178
            KLVK L   G+ V+GH GL PQ ++RL GGY+I G  EE+ ++++ DA +LE+AG   +
Sbjct: 126 AKLVKTLTDEGVIVVGHIGLMPQ-FVRLDGGYKIKGKNEEQQKKLLEDALSLEEAGVGLL 184

Query: 179 VLEFVLADVAKLVTEEVSIPTIGIGSGPYVDGQVLVWHDVLGLYEE-SPPFVKRYANLRD 237
           VLE +   +A+ +T+++ IPTIGIGSG   DGQ+LVW D+LG ++   P FV+ Y   ++
Sbjct: 185 VLEGITTPIAQTITQKIKIPTIGIGSGKDCDGQILVWSDMLGFFDSFKPKFVREYLKGKE 244

Query: 238 EILGAISEFKKDVKEGKFP 256
            I  AI ++  DVK+G FP
Sbjct: 245 LIQNAIQQYADDVKKGNFP 263


>pir||F83055 3-methyl-2-oxobutanoate hydroxymethyltransferase PA4729 [imported]
           - Pseudomonas aeruginosa (strain PAO1)
           >gi|9950989|gb|AAG08115.1|AE004886_7 (AE004886)
           3-methyl-2-oxobutanoate hydroxymethyltransferase
           [Pseudomonas aeruginosa]
           Length = 266
           
 Score =  204 bits (513), Expect = 1e-51
 Identities = 112/247 (45%), Positives = 158/247 (63%), Gaps = 3/247 (1%)

Query: 16  EKIAMITAYDYPSALLADKAGFDIVFVGDSLGMVVYGEPNTLNVSMEQMVFHTRAVARAV 75
           EKIAM+T YD   A  A +AG D++ VGDSLGMV+ G  +TL VS E+M +HT  V R  
Sbjct: 17  EKIAMLTCYDATFAHTASQAGVDVLLVGDSLGMVLQGHDSTLPVSNEEMAYHTACVKRGN 76

Query: 76  KRALVLADMPFGSYEVSVEEGIKNAIKLIQAGADAVKIEGGYDHKKLVKRLVRMGIPVMG 135
           K +L++ D+ F S   SV + + +A++L+QAGA  VK+EGG    + + RL +MG+PV  
Sbjct: 77  KGSLIVTDLAFESSH-SVAQTLADAVRLMQAGAHMVKLEGGVWLAEPIARLAQMGVPVCA 135

Query: 136 HTGLTPQRYLRLGGYRIMGSTEEEVEEIIRDAKALEKAGAFAVVLEFVLADVAKLVTEEV 195
           H GLTPQ     GG+++ G  E +  ++  DA ALE+AGA  ++LE V + +A+ +T+ V
Sbjct: 136 HLGLTPQAVNLFGGFKVQGRQETQARQLRADAIALEQAGAAMLLLECVPSVLAEEITQAV 195

Query: 196 SIPTIGIGSGPYVDGQVLVWHDVLG--LYEESPPFVKRYANLRDEILGAISEFKKDVKEG 253
            IP IGIG+G   DGQVLV HD+LG  L   SP FVK +   ++ I  AI+ + + VK+ 
Sbjct: 196 KIPVIGIGAGAATDGQVLVMHDMLGLSLTGRSPKFVKDFMQGQESIPAAIAAYVRAVKDV 255

Query: 254 KFPGREH 260
            FP  EH
Sbjct: 256 SFPAAEH 262


>pir||T50554 3-methyl-2-oxobutanoate hydroxymethyltransferase (EC 2.1.2.11)
           [imported] - Mycobacterium sp
           >gi|6980036|gb|AAF34708.1|AF223945_1 (AF223945)
           3-methyl-2-oxobutanoate hydroxymethyltransferase
           [Mycobacterium sp. PYR-1]
           Length = 280
           
 Score =  203 bits (512), Expect = 2e-51
 Identities = 106/246 (43%), Positives = 158/246 (64%), Gaps = 3/246 (1%)

Query: 17  KIAMITAYDYPSALLADKAGFDIVFVGDSLGMVVYGEPNTLNVSMEQMVFHTRAVARAVK 76
           K AM+TAYDY +A + D+A   ++ VGDS   VVYG   T+ V++++++   R V R   
Sbjct: 34  KWAMLTAYDYSTAAVFDEAEIPVLLVGDSAANVVYGYDTTVPVTLDELIPLVRGVVRGAP 93

Query: 77  RALVLADMPFGSYEVSVEEGIKNAIKLI-QAGADAVKIEGGYDHKKLVKRLVRMGIPVMG 135
            ALV+AD+PFGSYE   ++ +  A +++ + GA AVK+EGG      +  +   GIPVM 
Sbjct: 94  HALVVADLPFGSYEAGPQQALATATRMLKETGAHAVKLEGGERVADQIAAVSAAGIPVMA 153

Query: 136 HTGLTPQRYLRLGGYRIMGSTEEEVEEIIRDAKALEKAGAFAVVLEFVLADVAKLVTEEV 195
           H G TPQ    LGG+R+ G   +  E+ I DA A+++AGAFAVV+E V A++A  +T ++
Sbjct: 154 HIGFTPQSVNGLGGFRVQG-RGDAAEQTIHDAIAVQEAGAFAVVMEMVPAELATQITGKL 212

Query: 196 SIPTIGIGSGPYVDGQVLVWHDVLGLYE-ESPPFVKRYANLRDEILGAISEFKKDVKEGK 254
           +IPT+GIG+GP  D QVLVW D+ G+   ++  FVKR+  + DE+  A S++ ++V  G 
Sbjct: 213 TIPTVGIGAGPSCDAQVLVWQDMAGMTNGKTAKFVKRFGAVGDELRRAASDYAREVATGA 272

Query: 255 FPGREH 260
           FP  EH
Sbjct: 273 FPADEH 278


>pir||A47152 3-methyl-2-oxobutanoate hydroxymethyltransferase (EC 2.1.2.11) -
           Escherichia coli >gi|296059|emb|CAA46505.1| (X65538)
           3-methyl-2-oxobutanoate hydroxymethyltransferase
           [Escherichia coli]
           Length = 264
           
 Score =  203 bits (510), Expect = 3e-51
 Identities = 107/247 (43%), Positives = 153/247 (61%), Gaps = 2/247 (0%)

Query: 15  KEKIAMITAYDYPSALLADKAGFDIVFVGDSLGMVVYGEPNTLNVSMEQMVFHTRAVARA 74
           K++ A ITAYDY  A L    G +++ VGDSLGM V G  +TL V++E + +HT AV R 
Sbjct: 16  KKRFATITAYDYSFAKLFADEGLNVMLVGDSLGMTVQGHDSTLPVTVEDIAYHTAAVRRG 75

Query: 75  VKRALVLADMPFGSYEVSVEEGIKNAIKLIQAGADAVKIEGGYDHKKLVKRLVRMGIPVM 134
               L+LAD+PF +Y  + E+  +NA  +++AGA+ VKIEGG    + VK L    +PV 
Sbjct: 76  APNCLLLADLPFMAY-ATPEQAFENAATVMRAGANMVKIEGGEWLVETVKMLTERAVPVC 134

Query: 135 GHTGLTPQRYLRLGGYRIMGSTEEEVEEIIRDAKALEKAGAFAVVLEFVLADVAKLVTEE 194
           GH GLTPQ     GGY++ G  +E  ++++ DA ALE AGA  +VLE V  ++AK +TE 
Sbjct: 135 GHLGLTPQSVNIFGGYKVQGRGDEAGDQLLSDALALEAAGAQLLVLECVPVELAKRITEA 194

Query: 195 VSIPTIGIGSGPYVDGQVLVWHDVLGLY-EESPPFVKRYANLRDEILGAISEFKKDVKEG 253
           ++IP IGIG+G   DGQ+LV HD  G+     P F K +     +I  A+ ++  +V+ G
Sbjct: 195 LAIPVIGIGAGNVTDGQILVMHDAFGITGGHIPKFAKNFLAETGDIRAAVRQYMAEVESG 254

Query: 254 KFPGREH 260
            +PG EH
Sbjct: 255 VYPGEEH 261


>sp|Q10505|PANB_MYCTU 3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE (KETOPANTOATE
           HYDROXYMETHYLTRANSFERASE) >gi|7433452|pir||E70776
           probable panB protein - Mycobacterium tuberculosis
           (strain H37RV) >gi|1261927|emb|CAA94648.1| (Z70692) panB
           [Mycobacterium tuberculosis] >gi|1336206|gb|AAB01232.1|
           (U57435) 3-methyl-2-oxobutanoate
           hydroxymethyltransferase [Mycobacterium bovis]
           Length = 281
           
 Score =  203 bits (510), Expect = 3e-51
 Identities = 109/246 (44%), Positives = 156/246 (63%), Gaps = 3/246 (1%)

Query: 17  KIAMITAYDYPSALLADKAGFDIVFVGDSLGMVVYGEPNTLNVSMEQMVFHTRAVARAVK 76
           K AM+TAYDY +A + D+AG  ++ VGDS   VVYG   T+ +S+++++   R V R   
Sbjct: 35  KWAMLTAYDYSTARIFDEAGIPVLLVGDSAANVVYGYDTTVPISIDELIPLVRGVVRGAP 94

Query: 77  RALVLADMPFGSYEVSVEEGIKNAIKLIQ-AGADAVKIEGGYDHKKLVKRLVRMGIPVMG 135
            ALV+AD+PFGSYE      +  A + ++  GA AVK+EGG    + +  L   GIPVM 
Sbjct: 95  HALVVADLPFGSYEAGPTAALAAATRFLKDGGAHAVKLEGGERVAEQIACLTAAGIPVMA 154

Query: 136 HTGLTPQRYLRLGGYRIMGSTEEEVEEIIRDAKALEKAGAFAVVLEFVLADVAKLVTEEV 195
           H G TPQ    LGG+R+ G   +  E+ I DA A+ +AGAFAVV+E V A++A  +T ++
Sbjct: 155 HIGFTPQSVNTLGGFRVQG-RGDAAEQTIADAIAVAEAGAFAVVMEMVPAELATQITGKL 213

Query: 196 SIPTIGIGSGPYVDGQVLVWHDVLGLY-EESPPFVKRYANLRDEILGAISEFKKDVKEGK 254
           +IPT+GIG+GP  DGQVLVW D+ G    ++  FVKRYA++  E+  A  ++ ++V  G 
Sbjct: 214 TIPTVGIGAGPNCDGQVLVWQDMAGFSGAKTARFVKRYADVGGELRRAAMQYAQEVAGGV 273

Query: 255 FPGREH 260
           FP  EH
Sbjct: 274 FPADEH 279


>sp|P31057|PANB_ECOLI 3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE (KETOPANTOATE
           HYDROXYMETHYLTRANSFERASE) >gi|7433442|pir||F64736
           3-methyl-2-oxobutanoate hydroxymethyltransferase (EC
           2.1.2.11) - Escherichia coli >gi|304927|gb|AAA24271.1|
           (L17086) alpha-ketopantoate hydroxymethyl transferase
           [Escherichia coli] >gi|1786326|gb|AAC73245.1| (AE000122)
           3-methyl-2-oxobutanoate hydroxymethyltransferase
           [Escherichia coli K12]
           Length = 264
           
 Score =  199 bits (500), Expect = 4e-50
 Identities = 105/247 (42%), Positives = 152/247 (61%), Gaps = 2/247 (0%)

Query: 15  KEKIAMITAYDYPSALLADKAGFDIVFVGDSLGMVVYGEPNTLNVSMEQMVFHTRAVARA 74
           K++ A ITAYDY  A L    G +++ VGDSLGM V G  +TL V++  + +HT AV R 
Sbjct: 16  KKRFATITAYDYSFAKLFADEGLNVMLVGDSLGMTVQGHDSTLPVTVADIAYHTAAVRRG 75

Query: 75  VKRALVLADMPFGSYEVSVEEGIKNAIKLIQAGADAVKIEGGYDHKKLVKRLVRMGIPVM 134
               L+LAD+PF +Y  + E+  +NA  +++AGA+ VKIEGG    + V+ L    +PV 
Sbjct: 76  APNCLLLADLPFMAY-ATPEQAFENAATVMRAGANMVKIEGGEWLVETVQMLTERAVPVC 134

Query: 135 GHTGLTPQRYLRLGGYRIMGSTEEEVEEIIRDAKALEKAGAFAVVLEFVLADVAKLVTEE 194
           GH GLTPQ     GGY++ G  +E  ++++ DA ALE AGA  +VLE V  ++AK +TE 
Sbjct: 135 GHLGLTPQSVNIFGGYKVQGRGDEAGDQLLSDALALEAAGAQLLVLECVPVELAKRITEA 194

Query: 195 VSIPTIGIGSGPYVDGQVLVWHDVLGLY-EESPPFVKRYANLRDEILGAISEFKKDVKEG 253
           ++IP IGIG+G   DGQ+LV HD  G+     P F K +     +I  A+ ++  +V+ G
Sbjct: 195 LAIPVIGIGAGNVTDGQILVMHDAFGITGGHIPKFAKNFLAETGDIRAAVRQYMAEVESG 254

Query: 254 KFPGREH 260
            +PG EH
Sbjct: 255 VYPGEEH 261


>sp|Q9ZEP8|PANB_PSEFL 3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE (KETOPANTOATE
           HYDROXYMETHYLTRANSFERASE) >gi|3970812|emb|CAA10222.1|
           (AJ130846) 3-methyl-2-oxobutanoate
           hydroxymethyltransferase [Pseudomonas fluorescens]
           Length = 266
           
 Score =  199 bits (500), Expect = 4e-50
 Identities = 108/259 (41%), Positives = 162/259 (61%), Gaps = 4/259 (1%)

Query: 4   ITPRKIIEMKGKEKIAMITAYDYPSALLADKAGFDIVFVGDSLGMVVYGEPNTLNVSMEQ 63
           +T  + +++KG EKI M+T YD   A  + +AG +++ VGDSLGMV+ G  +TL V+ ++
Sbjct: 6   LTTLQSLKLKG-EKITMLTCYDATFAHASCQAGIEVLLVGDSLGMVLQGNDSTLPVTTDE 64

Query: 64  MVFHTRAVARAVKRALVLADMPFGSYEVSVEEGIKNAIKLIQAGADAVKIEGGYDHKKLV 123
           + +HT +V R    A ++AD+PF  Y  ++E+  +NA KL+QAGA  +K+EG     + +
Sbjct: 65  LAYHTASVKRGNDGAFIIADLPFMGY-ATLEQTFQNAGKLMQAGAHMIKVEGAVWLAESI 123

Query: 124 KRLVRMGIPVMGHTGLTPQRYLRLGGYRIMGSTEEEVEEIIRDAKALEKAGAFAVVLEFV 183
           + L   G+PV  H GLTPQ    LGGY++ G  E +  ++  DA ALE+AGA  ++LE V
Sbjct: 124 RLLAERGVPVCAHMGLTPQSVNLLGGYKVQGRNEAQARQMRADAIALEQAGAAMILLECV 183

Query: 184 LADVAKLVTEEVSIPTIGIGSGPYVDGQVLVWHDVLGL--YEESPPFVKRYANLRDEILG 241
            +++A  +T+ V +P IGIG+G   DGQVLV HD+LGL      P FVK +   +  I  
Sbjct: 184 PSELAAEITQAVKVPVIGIGAGSATDGQVLVLHDMLGLSITGRVPKFVKNFMTGQASIHD 243

Query: 242 AISEFKKDVKEGKFPGREH 260
           A+S +  +VK   FPG EH
Sbjct: 244 ALSAYVAEVKGVTFPGAEH 262


>sp|Q09672|PANB_SCHPO PROBABLE 3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE
           (KETOPANTOATE HYDROXYMETHYLTRANSFERASE)
           >gi|1076894|pir||S55487 probable 3-methyl-2-oxobutanoate
           hydroxymethyltransferase  (EC 2.1.2.11) - fission yeast
           (Schizosaccharomyces pombe) >gi|854608|emb|CAA89959.1|
           (Z49811) 3-methyl-2-oxobutanoate
           hydroxymethyltransferase [Schizosaccharomyces pombe]
           Length = 267
           
 Score =  196 bits (494), Expect = 2e-49
 Identities = 108/266 (40%), Positives = 163/266 (60%), Gaps = 4/266 (1%)

Query: 1   MREITPRKIIEMK-GKEKIAMITAYDYPSALLADKAGFDIVFVGDSLGMVVYGEPNTLNV 59
           +++IT   + + K   +K A ITAYD   + L  + G  ++ VGDSLGM   G   TL V
Sbjct: 3   LKQITISTLRQWKLANKKFACITAYDASFSRLFAEQGMPVMLVGDSLGMTAQGHSTTLPV 62

Query: 60  SMEQMVFHTRAVARAVKRALVLADMPFGSYEVSVEEGIKNAIKLIQAGADAVKIEGGYDH 119
           S+E + +HT++V R     L++AD+PF SY  + E+  KNA  +++AGA+ VKIEGG + 
Sbjct: 63  SVEDIAYHTKSVRRGAPNRLLMADLPFMSYS-TWEDACKNAATVMRAGANIVKIEGGGNW 121

Query: 120 K-KLVKRLVRMGIPVMGHTGLTPQRYLRLGGYRIMGSTEEEVEEIIRDAKALEKAGAFAV 178
             ++V+RL    +PV GH GLTPQ     GGY+I G  +     +I +A+ LEK GA  +
Sbjct: 122 IFEIVQRLTERSVPVAGHLGLTPQSVNIFGGYKIQGREQSAAARLIENAQQLEKFGAQLL 181

Query: 179 VLEFVLADVAKLVTEEVSIPTIGIGSGPYVDGQVLVWHDVLGLYEESPP-FVKRYANLRD 237
           VLE +   +A+ +T+ +SIPTIGIG+G + DGQ+LV HD LG+    PP F K + +   
Sbjct: 182 VLECIPESLAEQITKTISIPTIGIGAGKHTDGQILVMHDALGITGGRPPKFAKNFLSGAG 241

Query: 238 EILGAISEFKKDVKEGKFPGREHYWE 263
           +I  AI  +  +V++G +P  EH ++
Sbjct: 242 DIRTAIQRYIYEVEQGLYPAEEHSFQ 267


>pir||E82832 3-methyl-2-oxobutanoate hydroxymethyltransferase XF0229 [imported]
           - Xylella fastidiosa (strain 9a5c)
           >gi|9105038|gb|AAF83042.1|AE003876_7 (AE003876)
           3-methyl-2-oxobutanoate hydroxymethyltransferase
           [Xylella fastidiosa]
           Length = 246
           
 Score =  196 bits (494), Expect = 2e-49
 Identities = 107/243 (44%), Positives = 150/243 (61%), Gaps = 3/243 (1%)

Query: 20  MITAYDYPSALLADKAGFDIVFVGDSLGMVVYGEPNTLNVSMEQMVFHTRAVARAVKRAL 79
           M+TAYD   A + D  G D+V VGDSLGMVV G  +TL VS+  MV+HT  VAR V++A+
Sbjct: 1   MLTAYDAGFARILDANGVDLVLVGDSLGMVVQGHDSTLPVSVHDMVYHTACVARGVRQAM 60

Query: 80  VLADMPFGSYEVSVEEGIKNAIKLIQAGADAVKIEGGYDHKKLVKRLVRMGIPVMGHTGL 139
           ++ D+PF + + S E  ++ A  L++ GA  +KIEG     +++  LV   IPV  H GL
Sbjct: 61  LVVDLPFQA-DASPERALEAATPLLRVGAQMIKIEGAGHKLEVISYLVEREIPVCSHLGL 119

Query: 140 TPQRYLRLGGYRIMGSTEEEVEEIIRDAKALEKAGAFAVVLEFVLADVAKLVTEEVSIPT 199
           TPQ  LR GGY++ G  EE    +  +A+A  +AGA  ++LE V + +A  +T +VS+PT
Sbjct: 120 TPQSVLRFGGYKVQGRGEEAGGRLRAEARAAVEAGATLLLLECVPSQLAAQITTDVSVPT 179

Query: 200 IGIGSGPYVDGQVLVWHDVLGL--YEESPPFVKRYANLRDEILGAISEFKKDVKEGKFPG 257
           IGIG+G   DGQVLV HD+LGL      P FVK +      + GA+  +   V++G FP 
Sbjct: 180 IGIGAGAGCDGQVLVLHDLLGLDSGHPRPKFVKDFLAHGGSVAGAVRAYANAVRDGSFPD 239

Query: 258 REH 260
            EH
Sbjct: 240 VEH 242


>pir||A82304 3-methyl-2-oxobutanoate hydroxymethyltransferase VC0592 [imported]
           - Vibrio cholerae (group O1 strain N16961)
           >gi|9655023|gb|AAF93759.1| (AE004144)
           3-methyl-2-oxobutanoate hydroxymethyltransferase [Vibrio
           cholerae]
           Length = 264
           
 Score =  194 bits (487), Expect = 1e-48
 Identities = 106/262 (40%), Positives = 160/262 (60%), Gaps = 3/262 (1%)

Query: 1   MREITPRKIIEMKGK-EKIAMITAYDYPSALLADKAGFDIVFVGDSLGMVVYGEPNTLNV 59
           M++IT   +++ K +  K A  TAYD   A L +     ++ VGDSLGMV+ GE +TL V
Sbjct: 1   MKKITINDLMKWKQEGRKFATSTAYDASFAQLFESQEMPVLLVGDSLGMVLQGETDTLPV 60

Query: 60  SMEQMVFHTRAVARAVKRALVLADMPFGSYEVSVEEGIKNAIKLIQAGADAVKIEGGYDH 119
           +++ + +HTR V +     L++ADMPF SY  + E+  +NA KL++AGA+ VKIEGG   
Sbjct: 61  TVDDIAYHTRCVRKGSPNCLLMADMPFMSY-ATPEQACENAAKLVRAGANMVKIEGGDWL 119

Query: 120 KKLVKRLVRMGIPVMGHTGLTPQRYLRLGGYRIMGSTEEEVEEIIRDAKALEKAGAFAVV 179
              VK L    +PV  H GLTPQ     GGY++ G  +++ + ++RDA AL++AGA  V+
Sbjct: 120 VDTVKMLTERAVPVCAHLGLTPQSVNIFGGYKVQGREQDKADRMVRDALALQEAGAQIVL 179

Query: 180 LEFVLADVAKLVTEEVSIPTIGIGSGPYVDGQVLVWHDVLGLYEE-SPPFVKRYANLRDE 238
           LE V A++A  +T+ + +P IGIG+G   DGQ+LV HD+ G+     P F K +     +
Sbjct: 180 LECVPAELANRITQILDVPVIGIGAGNGTDGQILVMHDMFGISANYMPKFSKNFLAETGD 239

Query: 239 ILGAISEFKKDVKEGKFPGREH 260
           I  A++++ +DV  G FP   H
Sbjct: 240 IRQAVAKYIEDVASGAFPDLAH 261


>sp|P57293|PANB_BUCAI 3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE (KETOPANTOATE
           HYDROXYMETHYLTRANSFERASE) >gi|10038879|dbj|BAB12914.1|
           (AP001118) 3-methyl-2-oxobutanoate
           hydroxymethyltransferase [Buchnera sp. APS]
           Length = 263
           
 Score =  192 bits (484), Expect = 3e-48
 Identities = 98/262 (37%), Positives = 160/262 (60%), Gaps = 3/262 (1%)

Query: 1   MREITPRKIIEMK-GKEKIAMITAYDYPSALLADKAGFDIVFVGDSLGMVVYGEPNTLNV 59
           M  IT  ++   K  K+K A ITAYD+  + L    G  ++ +GDSLGM + G  +TL V
Sbjct: 1   MESITISQLKNWKINKKKFAAITAYDFSFSRLFSNCGIPVILIGDSLGMTIQGHTSTLPV 60

Query: 60  SMEQMVFHTRAVARAVKRALVLADMPFGSYEVSVEEGIKNAIKLIQAGADAVKIEGGYDH 119
            +E + +HT+AV +      +++D+PF SY    ++ +KN  K+I++GA+ +K+EGG   
Sbjct: 61  KIEDIAYHTKAVRKGAPNTFLISDLPFMSY-YDTKQALKNTAKIIRSGANMIKMEGGKWL 119

Query: 120 KKLVKRLVRMGIPVMGHTGLTPQRYLRLGGYRIMGSTEEEVEEIIRDAKALEKAGAFAVV 179
            ++++ L    I + GH GL PQ +  LGGY++ G  E +  ++I +A  LE++G   ++
Sbjct: 120 IEIIRELSNRLILICGHIGLIPQSFHYLGGYKVQGRKENDANKLIDEALLLEESGINMLI 179

Query: 180 LEFVLADVAKLVTEEVSIPTIGIGSGPYVDGQVLVWHDVLGLYE-ESPPFVKRYANLRDE 238
           LE +   +AK +TE +SIP IGIGSG   DGQ+LV HD+LG+ E ++P F K + +  D 
Sbjct: 180 LECIPEKLAKKITESLSIPVIGIGSGKNTDGQILVMHDLLGITEGKTPSFTKNFLSESDS 239

Query: 239 ILGAISEFKKDVKEGKFPGREH 260
           I  AI ++  +V+   +P ++H
Sbjct: 240 IQKAIQKYIYEVEHSIYPSKKH 261


>pir||T51696 3-methyl-2-oxobutanoate hydroxymethyltransferase (EC 2.1.2.11)
           [imported] - Prochlorococcus sp
           >gi|5912565|emb|CAB56202.1| (AJ011025)
           3-methyl-2-oxobutanoate hydroxymethyltransferase
           [Prochlorococcus sp.]
           Length = 257
           
 Score =  189 bits (475), Expect = 3e-47
 Identities = 106/233 (45%), Positives = 154/233 (65%), Gaps = 9/233 (3%)

Query: 6   PRKIIEMKGK-EKIAMITAYDYPSALLADKAGFDIVFVGDSLGMVVYGEPNTLNVSMEQM 64
           P ++++ K K +KI  +TA+D  S  LA+ +G DIV VGDSL MV  G  +TL V++E M
Sbjct: 3   PSELVKYKKKSQKIIALTAWDSISGSLAEHSGADIVLVGDSLAMVCLGYKSTLPVTLENM 62

Query: 65  VFHTRAVARAVKR-----ALVLADMPFGSYEVSVEEGIKNAIKLIQ-AGADAVKIEGGYD 118
           ++HT AV+R   +     +L++ DMPF +Y+    + ++ A K+I+   A AVK+EG   
Sbjct: 63  IYHTNAVSRGFSKEIEEQSLLVCDMPFLTYQCGENKAVEYAGKIIKNTYAKAVKVEGADP 122

Query: 119 H-KKLVKRLVRMGIPVMGHTGLTPQRYLRLGGYRIMGSTEEEVEEIIRDAKALEKAGAFA 177
             + ++ RL+RMGIPVMGH GLTPQ YL LG ++  G+  E  E+I RDA +LEK G F+
Sbjct: 123 EVQNVISRLIRMGIPVMGHLGLTPQSYLNLG-FKQQGNNSESHEKIKRDALSLEKLGCFS 181

Query: 178 VVLEFVLADVAKLVTEEVSIPTIGIGSGPYVDGQVLVWHDVLGLYEESPPFVK 230
           +VLE +   +AK +  E+ IPTIGIG+G + DGQV V  D+LGL ++ PPF +
Sbjct: 182 IVLEHIPELLAKEIQTELEIPTIGIGAGKFCDGQVRVTADLLGLNDKQPPFCR 234


>gi|6319653 Probable 3-methyl-2-oxobutanoate hydroxymethyltransferase (EC
           2.1.2.11); Ecm31p [Saccharomyces cerevisiae]
           >gi|585643|sp|P38122|PANB_YEAST 3-METHYL-2-OXOBUTANOATE
           HYDROXYMETHYLTRANSFERASE (KETOPANTOATE
           HYDROXYMETHYLTRANSFERASE) >gi|626788|pir||S46047
           probable 3-methyl-2-oxobutanoate
           hydroxymethyltransferase  (EC 2.1.2.11) - yeast
           (Saccharomyces cerevisiae) >gi|536525|emb|CAA85137.1|
           (Z36045) ORF YBR176w [Saccharomyces cerevisiae]
           Length = 312
           
 Score =  177 bits (444), Expect = 1e-43
 Identities = 98/261 (37%), Positives = 159/261 (60%), Gaps = 10/261 (3%)

Query: 18  IAMITAYDYPSALLADKAGFDIVFVGDSLGMVVYGEPNTLNVSMEQMVFHTRAVARAVKR 77
           ++M TAYD+ +A   +KA  D++ VGDSL M   G  +T+ +S+ +  +H  +V RA   
Sbjct: 41  LSMCTAYDFITATWVNKANCDLLLVGDSLAMTSLGYDSTITLSLNEFKYHVASVCRAEGS 100

Query: 78  ALVLADMPFGSYEVSVEEGIKNAIKL--IQAGADAVKIEGGYDHK-----KLVKRLVRMG 130
           ++V+ DMPFG++E  + +G+KNAI +  + +   +VK+E G   K     K ++ L   G
Sbjct: 101 SMVVVDMPFGTFESGISDGLKNAIDIMKLDSKVTSVKVEVGSYTKDKYAMKFIEELCSRG 160

Query: 131 IPVMGHTGLTPQRYLRLGGYRIMGSTE-EEVEEIIRDAKALEKAGAFAVVLEFVLADVAK 189
           IPVM H GLTPQ+   LGGY++ GS    +++E+   A  L+K G +++++E V   +A+
Sbjct: 161 IPVMAHIGLTPQKVHSLGGYKVQGSKSLLQMQELYETAMQLQKIGCWSILIECVPHKMAQ 220

Query: 190 LVTEEVSIPTIGIGSGPYVDGQVLVWHDVLGLYEES-PPFVKRYANLRDEILGAISEFKK 248
            +T ++S+PTIGIG+G    GQVLV  D+LG+  +S P FVK+  N+ D     + E+  
Sbjct: 221 FITSKLSVPTIGIGAGNGTSGQVLVISDLLGMQGDSVPKFVKQAVNMTDIATQGLKEYIA 280

Query: 249 DVKEGKFPGREHYWEFQDKEE 269
            V++  FP R  +  F+ KE+
Sbjct: 281 SVEDRTFPERGTH-TFKVKED 300


>gb|AAA85381.1| (L47126) orf3 gene product [Synechocystis sp.]
           Length = 167
           
 Score =  131 bits (325), Expect = 1e-29
 Identities = 74/164 (45%), Positives = 107/164 (65%), Gaps = 4/164 (2%)

Query: 4   ITPRKIIEMKGKEK-IAMITAYDYPSALLADKAGFDIVFVGDSLGMVVYGEPNTLNVSME 62
           ITP ++++ K +++ I  +TA+D   A + D AG +I+ VGDSLGMV  G   TL VS++
Sbjct: 3   ITPTQLLDWKRQQRPIVALTAWDTAIASVLDAAGVEIILVGDSLGMVALGYETTLPVSLD 62

Query: 63  QMVFHTRAVARAVKRALVLADMPFGSYEVSVEEGIKNAIKLIQ-AGADAVKIEGGYDHK- 120
            M+ HT AV R V+RALV+ D+PF +Y+ S  + + +A +++Q  GA AVK+EGG+    
Sbjct: 63  TMIHHTAAVKRGVQRALVVCDLPFLTYQESPAQAMGSAGRVLQETGAQAVKLEGGHPRMV 122

Query: 121 KLVKRLVRMGIPVMGHTGLTPQRYLRLGGYRIMGSTEEEVEEII 164
           + V RL  +GIPVMGH GLTPQ   +L GYR  G      E+I+
Sbjct: 123 ETVARLTEVGIPVMGHVGLTPQSVHQL-GYRQQGQDPATAEKIL 165


>emb|CAB62149.1| (AJ245666) hypothetical protein [Sinorhizobium meliloti]
           Length = 266
           
 Score =  118 bits (294), Expect = 6e-26
 Identities = 85/275 (30%), Positives = 124/275 (44%), Gaps = 32/275 (11%)

Query: 2   REITPRKIIEMKGKEKIAMITAYDYPSALLADKAGFDIVFVGDSLGMVVYGEPNTLNVSM 61
           R  T   ++ MKGK ++ M+       A  A+KA  D+V V  +L    + E        
Sbjct: 4   RRPTVADLLSMKGKRQLTMLRVMTLEEAEAAEKARIDLVSVPPALLGPEFRE-------- 55

Query: 62  EQMVFHTRAVARAVKRALVLADMPFGSYEVSVEEGIKNAIKLIQAGADAVKIEGGYDHKK 121
                       A         + +G + V+ E+ I+ A + ++AG DAV          
Sbjct: 56  ------------AAPSVFAFPGLEYGDH-VTAEDYIRAAFQALKAGGDAVYCAASLS--- 99

Query: 122 LVKRLVRMGIPVMGHTGLTPQRYLRLGGYRIMGSTEEEVEEIIRDAKALEKAGAFAVVLE 181
            V+R+   GIPV GH GL P +    GG+R +G T     EI R  KALE+AGAFA  +E
Sbjct: 100 TVRRMRDEGIPVCGHVGLIPSKVTWTGGFRAVGKTAASALEIWRQTKALEEAGAFAAEIE 159

Query: 182 FVLADVAKLVTEEVSIPTIGIGSGPYVDGQVLVWHDVLGLYEESPP--------FVKRYA 233
            V  +VA  ++   S+  + +G+G   D Q L   DVLG      P        F   Y 
Sbjct: 160 VVPGEVAAAISARTSMLMLSMGAGTGCDAQYLFAEDVLGANRGHYPRHAKTYRNFAAEYD 219

Query: 234 NLRDEILGAISEFKKDVKEGKFPGREHYWEFQDKE 268
            L+ E + A SEF  DV+ G +P + H    ++KE
Sbjct: 220 RLQQERIAAFSEFAFDVRSGAYPEKGHLVGIEEKE 254


  Database: ./suso.pep
    Posted date:  Jul 6, 2001  5:57 PM
  Number of letters in database: 840,471
  Number of sequences in database:  2977
  
  Database: /banques/blast2/nr.pep
    Posted date:  Dec 14, 2000 12:46 PM
  Number of letters in database: 188,266,275
  Number of sequences in database:  595,510
  
Lambda     K      H
   0.319    0.139    0.393 

Gapped
Lambda     K      H
   0.270   0.0470    0.230 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 100059955
Number of Sequences: 2977
Number of extensions: 4083951
Number of successful extensions: 11199
Number of sequences better than 1.0e-10: 36
Number of HSP's better than  0.0 without gapping: 36
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 11083
Number of HSP's gapped (non-prelim): 36
length of query: 282
length of database: 189,106,746
effective HSP length: 56
effective length of query: 226
effective length of database: 155,591,474
effective search space: 35163673124
effective search space used: 35163673124
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 41 (21.7 bits)
S2: 164 (68.3 bits)