BLASTP 2.0.10 [Aug-26-1999]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= PAB0605 (metB) DE:CYSTATHIONINE GAMMA-SYNTHASE (EC 4.2.99.9)
(CGS) (O-SUCCINYLHOMOSERINE (THIOL)-LYASE).
(393 letters)
Database: ./suso.pep; /banques/blast2/nr.pep
598,487 sequences; 189,106,746 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
pir||H75137 probable carbon-sulfur lyase (EC 4.4.1.-) PAB0605 - ... 789 0.0
pir||B71104 probable cystathionine gamma-lyase - Pyrococcus hori... 596 e-169
pir||F72511 probable cystathionine gamma-synthase APE2068 - Aero... 291 7e-78
gb|AAK42519.1| O-succinylhomoserine (thiol)-lyase (cystathionine... 287 1e-76
emb|CAC11671.1| (AL445064) probable cystathionine gamma-synthase... 277 2e-73
pir||T47232 cystathionine beta-lyase (EC 4.4.1.8) metC [validate... 252 4e-66
pir||A69974 cystathionine gamma-synthase homolog yrhB - Bacillus... 245 5e-64
sp|P56069|METB_HELPY CYSTATHIONINE GAMMA-SYNTHASE (CGS) (O-SUCCI... 245 5e-64
pir||A72595 probable cystathionine gamma-lyase APE1226 - Aeropyr... 245 8e-64
gb|AAF14695.1|AF131881_1 (AF131881) cystathionine beta-lyase Met... 245 8e-64
pir||D75458 trans-sulfuration enzyme - Deinococcus radiodurans (... 243 2e-63
gb|AAG19260.1| (AE005022) cystathionine gamma-synthase; Cgs [Hal... 240 2e-62
sp|Q9ZMW7|METB_HELPJ CYSTATHIONINE GAMMA-SYNTHASE (CGS) (O-SUCCI... 234 2e-60
dbj|BAB04518.1| (AP001509) methionine gamma lyase [Bacillus halo... 233 2e-60
dbj|BAB05347.1| (AP001512) cystathionine beta-lyase [Bacillus ha... 233 2e-60
emb|CAA04124.1| (AJ000486) methionine gamma-lyase [Trichomonas v... 233 2e-60
pir||A69847 cystathionine gamma-synthase homolog yjcI - Bacillus... 233 3e-60
emb|CAA04125.1| (AJ000487) methionine gamma-lyase [Trichomonas v... 232 5e-60
pir||E82752 cystathionine gamma-synthase XF0864 [imported] - Xyl... 231 1e-59
pir||B69847 cystathionine beta-lyase homolog yjcJ - Bacillus sub... 231 1e-59
pir||T47234 O-succinylhomoserine (thiol)-lyase (EC 4.2.99.9) [va... 229 5e-59
gi|6319307 cystathionine gamma-lyase; Cys3p [Saccharomyces cerev... 229 5e-59
dbj|BAB04261.1| (AP001508) cystathionine gamma-synthase [Bacillu... 228 7e-59
gb|AAG19548.1| (AE005045) cystathionine alpha synthase; MetB [Ha... 227 2e-58
dbj|BAB05346.1| (AP001512) cystathionine gamma-synthase (O-succi... 226 3e-58
sp|P55218|METZ_PSEAE O-SUCCINYLHOMOSERINE SULFHYDRYLASE (OSH SUL... 226 3e-58
pir||T21246 hypothetical protein F22B8.6 - Caenorhabditis elegan... 226 5e-58
sp|P13254|MEGL_PSEPU METHIONINE GAMMA-LYASE (L-METHIONINASE) >gi... 225 6e-58
dbj|BAB05455.1| (AP001513) cystathionine gamma-lyase [Bacillus h... 224 1e-57
sp|P44502|METB_HAEIN CYSTATHIONINE GAMMA-SYNTHASE (CGS) (O-SUCCI... 223 3e-57
gb|AAF74980.1|AF082890_1 (AF082890) cystathionine beta-lyase [So... 223 3e-57
pir||G64047 cystathionine gamma-lyase homolog - Haemophilus infl... 223 3e-57
pir||F83595 probable cystathionine gamma-lyase PA0400 [imported]... 222 4e-57
sp|O53427|METB_MYCTU CYSTATHIONINE GAMMA-SYNTHASE (CGS) (O-SUCCI... 222 5e-57
pir||T43791 cystathionine beta-synthase [imported] - Clostridium... 222 7e-57
gb|AAF57663.1| (AE003799) Eip55E gene product [Drosophila melano... 221 1e-56
sp|P55216|CGL_CAEEL PUTATIVE CYSTATHIONINE GAMMA-LYASE (GAMMA-CY... 220 3e-56
pir||T45483 cystathionine gamma-lyase homolog [imported] - Steno... 220 3e-56
gb|AAB03240.1| (L43133) L-methionine-alpha-deamino-gamma-mercapt... 218 8e-56
gb|AAD17839.1| (AF095822) ecdysteroid-inducible polypeptide EIP4... 218 8e-56
gb|AAF74982.1|AF082892_1 (AF082892) cystathionine gamma-synthase... 217 1e-55
emb|CAA64383.1| (X94756) cystathionine gamma-synthase [Arabidops... 217 2e-55
gb|AAB41235.1| (U83500) cystathionine gamma-synthase [Arabidopsi... 217 2e-55
pir||T12288 O-succinylhomoserine (thiol)-lyase (EC 4.2.99.9) - c... 217 2e-55
emb|CAA04772.2| (AJ001451) cystathionine gamma synthase [Fragari... 217 2e-55
gi|4503125 cystathionase (cystathionine gamma-lyase); Cystathion... 216 3e-55
gi|11424797 similar to cystathionase (cystathionine gamma-lyase)... 216 3e-55
sp|P53780|METC_ARATH CYSTATHIONINE BETA-LYASE PRECURSOR (CBL) (B... 216 4e-55
sp|P55217|METB_ARATH CYSTATHIONINE GAMMA-SYNTHASE, CHLOROPLAST P... 216 4e-55
dbj|BAA95820.1| (AP002069) EST AU082557(R0845) corresponds to a ... 215 5e-55
dbj|BAA95830.1| (AP002069) EST AU082557(R0845) corresponds to a ... 215 5e-55
pir||T44655 O-acetylhomoserine (thiol)-lyase (EC 4.2.99.10) [imp... 215 5e-55
emb|CAC05298.1| (AJ293860) cystathionine beta-lyase [Lactobacill... 215 7e-55
gb|AAC49574.1| (U43709) similar to the metB gene product of Esch... 214 1e-54
pir||B81949 cystathionine beta-lyase (EC 4.4.1.8) NMA1012 [simil... 214 1e-54
pir||A81158 cystathionine beta-lyase (EC 4.4.1.8) NMB0802 [simil... 213 3e-54
pir||T02940 O-succinylhomoserine (thiol)-lyase (EC 4.2.99.9) 1 -... 212 5e-54
emb|CAA09983.1| (AJ012295) O-succinylhomoserine sulfhydrylase [R... 212 5e-54
pir||S52983 probable cystathionine gamma-lyase (EC 4.4.1.1) - Er... 210 2e-53
pdb|1QGN|A Chain A, Cystathionine Gamma-Synthase From Nicotiana ... 210 2e-53
sp|P00935|METB_ECOLI CYSTATHIONINE GAMMA-SYNTHASE (CGS) (O-SUCCI... 209 4e-53
gb|AAF74981.1|AF082891_1 (AF082891) cystathionine gamma-synthase... 209 4e-53
gb|AAG38873.1|AF076495_1 (AF076495) cystathionine gamma-synthase... 209 4e-53
gb|AAC83351.1| (AF092918) MetZ homolog [Pseudomonas alcaligenes] 209 5e-53
gi|8393215 CTL target antigen [Rattus norvegicus] >gi|1705789|sp... 209 5e-53
pir||E83018 homocysteine synthase PA5025 [imported] - Pseudomona... 208 7e-53
pir||T02942 O-succinylhomoserine (thiol)-lyase (EC 4.2.99.9) 1 -... 208 7e-53
pdb|1CS1|A Chain A, Cystathionine Gamma-Synthase (Cgs) From Esch... 207 2e-52
gb|AAF97598.1|AF286193_1 (AF286193) cystathionine-gamma-lyase [A... 206 3e-52
pir||G81062 trans-sulfuration enzyme family protein NMB1609 [imp... 206 4e-52
pir||A82045 cystathionine gamma-synthase VC2683 [imported] - Vib... 205 6e-52
sp|P46807|METB_MYCLE CYSTATHIONINE GAMMA-SYNTHASE (CGS) (O-SUCCI... 205 8e-52
sp|Q59829|CYSA_STRCO PUTATIVE CYSTATHIONINE GAMMA-LYASE (GAMMA-C... 205 8e-52
pir||E81806 O-succinylhomoserine sulfhydrolase (EC 4.2.99.-) NMA... 205 8e-52
pir||T37173 probable cystathionine/methionine gamma-synthase/lya... 205 1e-51
emb|CAC11228.1| (AL445063) cystathionine gamma-lyase related pro... 204 2e-51
pir||T19213 hypothetical protein C12C8.2 - Caenorhabditis elegan... 203 4e-51
gb|AAD34548.1|AF141602_1 (AF141602) cystathionine-gamma-synthase... 202 7e-51
pir||E72274 cystathionine gamma-synthase - Thermotoga maritima (... 200 2e-50
gb|AAF69585.1|AC019154_4 (AC019154) Cystathionine Gamma Synthase... 199 6e-50
gb|AAB03241.1| (U28383) cystathionine beta-lyase [Aspergillus ni... 198 1e-49
emb|CAA37547.1| (X53460) cystathionine gamma-lyase. [Rattus norv... 196 5e-49
pir||F70632 probable metZ protein - Mycobacterium tuberculosis (... 195 9e-49
pir||C81271 probable O-acetylhomoserine (thiol)-lyase (EC 4.2.99... 192 7e-48
pir||G75463 O-acetylhomoserine (thiol)-lyase - Deinococcus radio... 191 1e-47
dbj|BAB06322.1| (AP001516) O-acetylhomoserine sulfhydrylase [Bac... 191 1e-47
emb|CAA18941.1| (AL023514) O-succinylhomoserine sulfhydrylase [M... 189 6e-47
pir||S71228 O-succinylhomoserine (thiol)-lyase (EC 4.2.99.9) 1 -... 188 8e-47
gb|AAF20155.1|AF211176_1 (AF211176) cystathionine beta-lyase [Bo... 187 2e-46
pir||D72324 O-acetylhomoserine sulfhydrylase - Thermotoga mariti... 186 4e-46
dbj|BAA13427.1| (D87664) QAH/OAS sulfhydrylase [Thermus aquaticus] 185 6e-46
pir||A75306 O-acetylhomoserine (thiol)-lyase/O-acetylserine (th... 184 2e-45
sp|P24601|METB_HERAU PROBABLE CYSTATHIONINE GAMMA-SYNTHASE (CGS)... 182 6e-45
pir||C70846 probable metC protein - Mycobacterium tuberculosis (... 182 8e-45
gb|AAD31520.2|AF144102_1 (AF144102) cystathionine-gamma-synthase... 181 1e-44
gb|AAG21602.1|AC051630_3 (AC051630) cystathionine gamma-synthase... 178 1e-43
gb|AAG27903.1|AC027035_2 (AC027035) cystathionine gamma-synthase... 178 1e-43
gb|AAG20508.1| (AE005123) O-acetyl homoserine; Hal [Halobacteriu... 177 2e-43
pir||T40463 O-acetylhomoserine (thiol)-lyase (EC 4.2.99.10) - fi... 175 6e-43
emb|CAB95232.1| (AL359773) cystathionine beta-lyase [Leishmania ... 161 1e-38
pir||JC1362 cystathionine gamma-lyase (EC 4.4.1.1) - human >gi|2... 161 1e-38
gi|6323333 O-Acetylhomoserine-O-Acetylserine Sulfhydralase; Met1... 161 2e-38
pir||S51579 cystathionine gamma-lyase (EC 4.4.1.1) 1 - Arabidops... 157 2e-37
gb|AAF19680.1|AC009519_14 (AC009519) F1N19.23 [Arabidopsis thali... 155 6e-37
pir||D47293 probable dihydrorhizobitoxine synthase RtxAB - Brady... 155 8e-37
emb|CAA62738.1| (X91393) orf1 [Streptomyces antibioticus] 152 9e-36
sp|Q07703|METC_BORAV CYSTATHIONINE BETA-LYASE (CBL) (BETA-CYSTAT... 150 2e-35
sp|Q92441|MT17_KLULA MET17 PROTEIN [INCLUDES: O-ACETYLHOMOSERINE... 150 3e-35
sp|P06721|METC_ECOLI CYSTATHIONINE BETA-LYASE (CBL) (BETA-CYSTAT... 147 2e-34
pdb|1CL1|A Chain A, Cystathionine Beta-Lyase (Cbl) From Escheric... 145 1e-33
gb|AAA69175.1| (U28377) beta-cystathionase [Escherichia coli] 144 2e-33
pir||C81284 cystathionine beta-lyase truncated homolog Cj1393 [i... 144 2e-33
pir||T40852 cystathionine lyase precursor - fission yeast (Schi... 144 2e-33
pir||D82171 cystathionine beta-lyase VC1671 [imported] - Vibrio ... 142 8e-33
gi|6321254 Cystathionine beta-lyase; Str3p [Saccharomyces cerevi... 141 1e-32
sp|P44527|METC_HAEIN CYSTATHIONINE BETA-LYASE (CBL) (BETA-CYSTAT... 139 4e-32
sp|P18949|METC_SALTY CYSTATHIONINE BETA-LYASE (CBL) (BETA-CYSTAT... 138 9e-32
gb|AAD56929.1|AF180145_21 (AF180145) cystathionine-gamma-lyase [... 135 1e-30
gi|6321904 Cystathionine gamma-synthase; Yhr112cp [Saccharomyces... 132 7e-30
pir||T38233 probable cystathionine gamma-synthase - fission yeas... 115 1e-24
emb|CAB53378.1| (AJ132742) MetY protein [Bordetella bronchiseptica] 104 1e-21
gi|6321170 Yfr055wp [Saccharomyces cerevisiae] >gi|1170931|sp|P4... 104 2e-21
sp|P38675|MET7_NEUCR CYSTATHIONINE GAMMA-SYNTHASE (O-SUCCINYLHOM... 91 2e-17
>pir||H75137 probable carbon-sulfur lyase (EC 4.4.1.-) PAB0605 - Pyrococcus
abyssi (strain Orsay) >gi|5458328|emb|CAB49817.1|
(AJ248285) CYSTATHIONINE GAMMA-SYNTHASE (EC 4.2.99.9)
(CGS) (O-SUCCINYLHOMOSERINE (THIOL)-LYASE). [Pyrococcus
abyssi]
Length = 393
Score = 789 bits (2015), Expect = 0.0
Identities = 393/393 (100%), Positives = 393/393 (100%)
Query: 1 MVIFRIKNYVEKDINLPWDQREGEIKMKPLHDPLYITAVFKQVGDAYPTDRGTELKYSRE 60
MVIFRIKNYVEKDINLPWDQREGEIKMKPLHDPLYITAVFKQVGDAYPTDRGTELKYSRE
Sbjct: 1 MVIFRIKNYVEKDINLPWDQREGEIKMKPLHDPLYITAVFKQVGDAYPTDRGTELKYSRE 60
Query: 61 ENPTVRKLEDKLAELEGSDNALAFNSGMSAISTLYFSLLEGGDKVVLSMEGYGTTIELAK 120
ENPTVRKLEDKLAELEGSDNALAFNSGMSAISTLYFSLLEGGDKVVLSMEGYGTTIELAK
Sbjct: 61 ENPTVRKLEDKLAELEGSDNALAFNSGMSAISTLYFSLLEGGDKVVLSMEGYGTTIELAK 120
Query: 121 LLRKFGVDVKLAYPSADSLIETIDEETKLVLVETMTNPTLKVIDVPEVAKRCREVGAILV 180
LLRKFGVDVKLAYPSADSLIETIDEETKLVLVETMTNPTLKVIDVPEVAKRCREVGAILV
Sbjct: 121 LLRKFGVDVKLAYPSADSLIETIDEETKLVLVETMTNPTLKVIDVPEVAKRCREVGAILV 180
Query: 181 VDNTFVTPLLYKPLEDGASYVVHSLTKYIAGHNDVLGGAVLWNGEFSRDLWEWRRRLGTI 240
VDNTFVTPLLYKPLEDGASYVVHSLTKYIAGHNDVLGGAVLWNGEFSRDLWEWRRRLGTI
Sbjct: 181 VDNTFVTPLLYKPLEDGASYVVHSLTKYIAGHNDVLGGAVLWNGEFSRDLWEWRRRLGTI 240
Query: 241 IQPFDAWMIERGMRTLEVRFERQSENAMAIAEFLKDHPKVREVHYPGLKDDPYYKVARRL 300
IQPFDAWMIERGMRTLEVRFERQSENAMAIAEFLKDHPKVREVHYPGLKDDPYYKVARRL
Sbjct: 241 IQPFDAWMIERGMRTLEVRFERQSENAMAIAEFLKDHPKVREVHYPGLKDDPYYKVARRL 300
Query: 301 FKKDLYGGVVAFDLGSGDNALAFLRGLKRIFPSPSLGGVESIATYPVKSAAKTLDEEIRE 360
FKKDLYGGVVAFDLGSGDNALAFLRGLKRIFPSPSLGGVESIATYPVKSAAKTLDEEIRE
Sbjct: 301 FKKDLYGGVVAFDLGSGDNALAFLRGLKRIFPSPSLGGVESIATYPVKSAAKTLDEEIRE 360
Query: 361 ILGITDGLIRLSVGLEPLDELIEDIDNALGVVR 393
ILGITDGLIRLSVGLEPLDELIEDIDNALGVVR
Sbjct: 361 ILGITDGLIRLSVGLEPLDELIEDIDNALGVVR 393
>pir||B71104 probable cystathionine gamma-lyase - Pyrococcus horikoshii
>gi|3257509|dbj|BAA30192.1| (AP000004) 371aa long
hypothetical cystathionine gamma-lyase [Pyrococcus
horikoshii]
Length = 371
Score = 596 bits (1521), Expect = e-169
Identities = 285/369 (77%), Positives = 336/369 (90%), Gaps = 1/369 (0%)
Query: 26 KMKPLHDPLYITAVFKQVGDAYPTDRGTELKYSREENPTVRKLEDKLAELEGSDNALAFN 85
++KPLH+PLY+TAVF+QVG+AY T R TELKYSREENPTV LE+KLA+LEG+DNALAFN
Sbjct: 3 RLKPLHEPLYLTAVFRQVGEAYLTPRNTELKYSREENPTVLNLENKLAKLEGADNALAFN 62
Query: 86 SGMSAISTLYFSLLEGGDKVVLSMEGYGTTIELAKLL-RKFGVDVKLAYPSADSLIETID 144
SG++AI+TLYFS LE GD+ VLSMEGYGTTIELA+L+ R+FGV ++LAYP A+ ++E I+
Sbjct: 63 SGIAAIATLYFSFLEAGDEAVLSMEGYGTTIELARLIGRRFGVKIRLAYPRAEDIVEEIN 122
Query: 145 EETKLVLVETMTNPTLKVIDVPEVAKRCREVGAILVVDNTFVTPLLYKPLEDGASYVVHS 204
E TKLVL+ETMTNPTLKVIDV EVAKRCREV ILVVDNTFVTPLLYKPL+DGA++VVHS
Sbjct: 123 ERTKLVLIETMTNPTLKVIDVREVAKRCREVETILVVDNTFVTPLLYKPLKDGANFVVHS 182
Query: 205 LTKYIAGHNDVLGGAVLWNGEFSRDLWEWRRRLGTIIQPFDAWMIERGMRTLEVRFERQS 264
LTKYIAGHNDVLGGA+LWNGEF DLW WRRRLG IIQPFDAWMIERGMRTLEVRFERQS
Sbjct: 183 LTKYIAGHNDVLGGAILWNGEFIHDLWNWRRRLGGIIQPFDAWMIERGMRTLEVRFERQS 242
Query: 265 ENAMAIAEFLKDHPKVREVHYPGLKDDPYYKVARRLFKKDLYGGVVAFDLGSGDNALAFL 324
+NA AIAEFL +HPKV+EVHYPGL+DDPY+++A++LF++DLYGGVV+FD+G+ NA+ FL
Sbjct: 243 KNAQAIAEFLSEHPKVKEVHYPGLEDDPYHEIAKKLFERDLYGGVVSFDVGNESNAIVFL 302
Query: 325 RGLKRIFPSPSLGGVESIATYPVKSAAKTLDEEIREILGITDGLIRLSVGLEPLDELIED 384
R +K+IFPSPSLGGVESI TYPVKSAA+ ++EE RE LGIT+GLIRLSVGLEPLDEL+ED
Sbjct: 303 RSIKKIFPSPSLGGVESIVTYPVKSAARYINEEQREALGITEGLIRLSVGLEPLDELLED 362
Query: 385 IDNALGVVR 393
+D AL VV+
Sbjct: 363 LDKALEVVK 371
>pir||F72511 probable cystathionine gamma-synthase APE2068 - Aeropyrum pernix
(strain K1) >gi|5105766|dbj|BAA81078.1| (AP000063) 389aa
long hypothetical cystathionine gamma-synthase
[Aeropyrum pernix]
Length = 389
Score = 291 bits (738), Expect = 7e-78
Identities = 164/373 (43%), Positives = 238/373 (62%), Gaps = 12/373 (3%)
Query: 28 KPLHDPLYITAVFKQVGDAYPTD--RGTELKYSREENPTVRKLEDKLAELEGSDNALAFN 85
+P+ P+ ++A++ ++ + R +LKY RE NPTV LE+ L LE + LAFN
Sbjct: 21 EPVVPPVNVSAIYVHPPGSFEREYPRVGDLKYGRENNPTVLGLEEALTSLEEARWTLAFN 80
Query: 86 SGMSAISTLYF-SLLEGGDKVVLSMEGYGTTIELAKLLRKF-GVDVKLAYPSADSLIETI 143
SGM+A+STL + G KV+L YG+T L ++L G++V+LA P + L++ +
Sbjct: 81 SGMAALSTLVLHEVSRGAKKVLLERLTYGSTRSLLEMLSSITGIEVRLAGPPWEDLLDLV 140
Query: 144 DEETKLVLVETMTNPTLKVIDVPEVAKRCREVGAILVVDNTFVTPLLYKPLEDGASYVVH 203
L++VE+M NPTL+V + + + G +VVDNTF TP+ Y+PLE GA Y +
Sbjct: 141 CW-ADLIIVESMANPTLRVPPLSGIYREAGSCGVRVVVDNTFATPIAYRPLERGAHYSLE 199
Query: 204 SLTKYIAGHNDVLGGAVLWNGEFSRD---LWEWRRRLGTIIQPFDAWMIERGMRTLEVRF 260
SLTKYIAGHNDV+GG++ +G D LW R+ LGTI+QP DA++ RGM+TL+ RF
Sbjct: 200 SLTKYIAGHNDVVGGSL--SGRVEEDLEPLWNMRKILGTIMQPIDAYLAWRGMKTLKARF 257
Query: 261 ERQSENAMAIAEFLKDHPKVREVHYPGLKDDPYYKVARRLFKKDLYGGVVAFDL-GSGDN 319
E QS A+ +AE+L+ H KV++V+YPGL P +++ARR LYG VV+F++ G +
Sbjct: 258 EAQSRAAVEVAEWLESHRKVKKVYYPGLSSHPDHELARREL-NGLYGAVVSFEIEGGREE 316
Query: 320 ALAFLRGLKRIFPSPSLGGVESIATYPVKSAAKTLDEEIREILGITDGLIRLSVGLEPLD 379
L LK + PSPS GGVE+I +YP S+ LD R LG+TDGL+RLSVGLE +
Sbjct: 317 VFKLLSRLKLVTPSPSFGGVETIISYPAISSHSNLDPLERSELGVTDGLLRLSVGLEDVS 376
Query: 380 ELIEDIDNALGVV 392
++I+D+ AL +
Sbjct: 377 DIIDDLSQALSAI 389
>gb|AAK42519.1| O-succinylhomoserine (thiol)-lyase (cystathionine gamma-synthase)
(metB) [Sulfolobus solfataricus]
Length = 376
Score = 287 bits (728), Expect = 1e-76
Identities = 154/363 (42%), Positives = 239/363 (65%), Gaps = 12/363 (3%)
Query: 33 PLYITAVFKQVGDAYPTDRGTELKYSREENPTVRKLEDKLAELEGSDNALAFNSGMSAIS 92
P+Y T+ AY G + +YSRE NPTV +L K+ ELE ++ +AF+SGM AIS
Sbjct: 22 PIYQTS-------AYHYPEGEKYRYSRESNPTVLELAKKIVELENAEMGIAFSSGMGAIS 74
Query: 93 TLYFSLLEGGDKVVLSMEGYGTTIEL-AKLLRKFGVDVKLAYPSADSLIETIDEET-KLV 150
T +LL+ G+ V++ + +G + L+ +GV+V+ +YP +++IE + ++
Sbjct: 75 TTALALLKPGNSVLVHRDMFGRSYRFFTDYLKNWGVNVEASYPGNNNIIEKAKSKRYDVI 134
Query: 151 LVETMTNPTLKVIDVPEVAKRCREVGAILVVDNTFVTPLLYKPLEDGASYVVHSLTKYIA 210
VE +TNP L+VIDV E++K +E G+IL+VD TF TP+ KPLE GA VVHS +K++A
Sbjct: 135 FVENITNPLLRVIDVAELSKVAKEQGSILIVDATFSTPINQKPLELGADIVVHSASKFLA 194
Query: 211 GHNDVLGGAVLWNGEFSRDLWEWRRRLGTIIQPFDAWMIERGMRTLEVRFERQSENAMAI 270
GHNDV+ G ++ + + RR LGT + P A++ RG++TL++R + + NA I
Sbjct: 195 GHNDVIAGLAAGYSKYLNVIDQMRRTLGTSLDPHAAYLTLRGIKTLKIRMDVINRNAEQI 254
Query: 271 AEFLKDHPKVREVHYPGLKDDPYYKVARRLFKKDLYGGVVAFDLGSG-DNALAFLRGLKR 329
AEFL+ HPKV +V+YPGLK Y +AR++ K +GGV++F++ G ++AL ++ LK
Sbjct: 255 AEFLEGHPKVVKVYYPGLKSHVDYDIARKVLKG--FGGVLSFEVNGGQESALKVMKSLKL 312
Query: 330 IFPSPSLGGVESIATYPVKSAAKTLDEEIREILGITDGLIRLSVGLEPLDELIEDIDNAL 389
I P+ +LGGV S+ ++P + +TL E R+I+GITD L+RLSVG+E +++LIED+D AL
Sbjct: 313 IIPAQTLGGVNSVISHPATMSHRTLSLEERKIVGITDSLLRLSVGIEDVNDLIEDLDRAL 372
Query: 390 GVV 392
+
Sbjct: 373 STL 375
>emb|CAC11671.1| (AL445064) probable cystathionine gamma-synthase [Thermoplasma
acidophilum]
Length = 380
Score = 277 bits (700), Expect = 2e-73
Identities = 141/358 (39%), Positives = 230/358 (63%), Gaps = 10/358 (2%)
Query: 33 PLYITAVFKQVGDAYPTDRGTELKYSREENPTVRKLEDKLAELEGSDNALAFNSGMSAIS 92
P+Y T AY + G +YSRE NPTV +L +++ LEGS A F+SGM +IS
Sbjct: 26 PIYATT-------AYRSPEGDHFRYSRENNPTVEELARQISLLEGSQLAACFSSGMGSIS 78
Query: 93 TLYFSLLEGGDKVVLSMEGYGTTIELAK-LLRKFGVDVKLAYPSADSLIETIDEETKLVL 151
T++ SLL+ GD +VL M+ +G T AK L +FG++V + P D +IE I ++T+++
Sbjct: 79 TVFLSLLKPGDGLVLPMDVFGRTYLFAKDFLSRFGINVSITDPGTDKVIEAIGDKTRMIF 138
Query: 152 VETMTNPTLKVIDVPEVAKRCREVGAILVVDNTFVTPLLYKPLEDGASYVVHSLTKYIAG 211
VE+++NP L+V D+ ++ ++ A+LVVD+T +TP+ + ++ GA VV+SL+K+I G
Sbjct: 139 VESLSNPVLRVYDIKRLSDSAKQNNALLVVDDTIITPVGQRAIDHGADIVVNSLSKFIGG 198
Query: 212 HNDVLGGAVLWNGEFSRDLWEWRRRLGTIIQPFDAWMIERGMRTLEVRFERQSENAMAIA 271
HN +GG+ + EF +++ RR LG+ + PF A++ +GM+TL++R ER S +A IA
Sbjct: 199 HNAAIGGSSSGSSEFIKNIDSDRRSLGSSMDPFSAFLFLQGMKTLKIRIERSSRSAQIIA 258
Query: 272 EFLKDHPKVREVHYPGLKDDPYYKVARRLFKKDLYGGVVAFDLGSGDNALAFLRGLKRIF 331
E L V V+YPGL ++ Y+ +A R K YG VV+F L G +A F+ L+RI
Sbjct: 259 EHLSTLDHVERVYYPGLTENDYHDLALRTLKN--YGSVVSFVLDDGVDASKFMSSLERII 316
Query: 332 PSPSLGGVESIATYPVKSAAKTLDEEIREILGITDGLIRLSVGLEPLDELIEDIDNAL 389
P+ ++G VE++ + P + + L ++ R +G+ GL+RLSVG+E + ++++DI+NA+
Sbjct: 317 PANTMGSVETLISNPYSMSHRNLSDKERARIGVVPGLMRLSVGIEEISDIMDDIENAI 374
>pir||T47232 cystathionine beta-lyase (EC 4.4.1.8) metC [validated] -
Lactococcus lactis subsp. cremoris
>gi|6513595|gb|AAF14693.1|AF131880_1 (AF131880)
cystathionine beta-lyase MetC [Lactococcus lactis subsp.
cremoris] >gi|7106219|gb|AAF36088.1|AF170901_1
(AF170901) cystathionine beta/gamma-lyase [Lactococcus
lactis subsp. cremoris]
Length = 380
Score = 252 bits (638), Expect = 4e-66
Identities = 140/360 (38%), Positives = 215/360 (58%), Gaps = 10/360 (2%)
Query: 33 PLYITAVFKQVGDAYPTDRGTELKYSREENPTVRKLEDKLAELEGSDNALAFNSGMSAIS 92
P+Y T+ +KQ G P E +YSR NPT LE+ +A+LEG AF+SG++ I
Sbjct: 25 PIYQTSTYKQNGLGQPK----EYEYSRSGNPTRHALEELIADLEGGVQGFAFSSGLAGIH 80
Query: 93 TLYFSLLEGGDKVVLSMEGYGTTIELA-KLLRKFGVDVKLA-YPSADSLIETIDEETKLV 150
+ SL GD ++L+ + YG T L K+L K G+ L + D L EETK +
Sbjct: 81 AV-LSLFSAGDHIILADDVYGGTFRLMDKVLTKTGIIYDLVDLSNLDDLKAAFKEETKAI 139
Query: 151 LVETMTNPTLKVIDVPEVAKRCREVGAILVVDNTFVTPLLYKPLEDGASYVVHSLTKYIA 210
ET +NP LKV+D+ E++ + A+ +VDNTF TP L +P+ GA V+HS TKY+
Sbjct: 140 YFETPSNPLLKVLDIKEISAIAKAHDALTLVDNTFATPYLQQPIALGADIVLHSATKYLG 199
Query: 211 GHNDVLGGAVLWNG-EFSRDLWEWRRRLGTIIQPFDAWMIERGMRTLEVRFERQSENAMA 269
GH+DV+ G V N E + ++ + +G ++ P D+W+++RG++TL +R E S NA
Sbjct: 200 GHSDVVAGLVTTNSKELASEIGFLQNSIGAVLGPQDSWLVQRGIKTLALRMEAHSANAQK 259
Query: 270 IAEFLKDHPKVREVHYPGLKDDPYYKVARRLFKKDLYGGVVAFDLGSGDNALAFLRGLKR 329
IAEFL+ V +V+YPGL P +++A++ + +GG+++F+L + F+ L
Sbjct: 260 IAEFLETSKAVSKVYYPGLNSHPGHEIAKK--QMSAFGGMISFELTDENAVKDFVENLSY 317
Query: 330 IFPSPSLGGVESIATYPVKSAAKTLDEEIREILGITDGLIRLSVGLEPLDELIEDIDNAL 389
+ SLGGVES+ P ++ +E+RE +GI DGLIRLSVG+E +++L+ DI AL
Sbjct: 318 FTLAESLGGVESLIEVPAVMTHASIPKELREEIGIKDGLIRLSVGVEAIEDLLTDIKEAL 377
>pir||A69974 cystathionine gamma-synthase homolog yrhB - Bacillus subtilis
>gi|1934606|gb|AAB80859.1| (U93874) cystathionine
gamma-lyase [Bacillus subtilis]
>gi|2635171|emb|CAB14667.1| (Z99117) similar to
cystathionine gamma-synthase [Bacillus subtilis]
Length = 379
Score = 245 bits (620), Expect = 5e-64
Identities = 143/370 (38%), Positives = 218/370 (58%), Gaps = 10/370 (2%)
Query: 23 GEIKMKPLHDPLYITAVFKQVGDAYPTDRGTELKYSREENPTVRKLEDKLAELEGSDNAL 82
G+ K + P+Y + +KQ + T +YSR NPT LE + ELE +
Sbjct: 14 GDEKTGAVSVPIYQVSTYKQP----KAGQHTGYEYSRTANPTRTALEALVTELESGEAGY 69
Query: 83 AFNSGMSAISTLYFSLLEGGDKVVLSMEGYGTTIE-LAKLLRKFGVDVKLAYPSADSLIE 141
AF+SGM+AI T L GD VVL+ + YG T + K+L + G++ S+ +E
Sbjct: 70 AFSSGMAAI-TAVMMLFNSGDHVVLTDDVYGGTYRVMTKVLNRLGIESTFVDTSSREEVE 128
Query: 142 -TIDEETKLVLVETMTNPTLKVIDVPEVAKRCREVGAILVVDNTFVTPLLYKPLEDGASY 200
I TK + +ET TNP LK+ D+ +A ++ G +L+VDNTF TP +PL GA
Sbjct: 129 KAIRPNTKAIYIETPTNPLLKITDLTLMADIAKKAGVLLIVDNTFNTPYFQQPLTLGADI 188
Query: 201 VVHSLTKYIAGHNDVLGGAVLW-NGEFSRDLWEWRRRLGTIIQPFDAWMIERGMRTLEVR 259
V+HS TKY+ GH+DV+GG V+ + E +L + G ++ P D+W++ RG++TL +R
Sbjct: 189 VLHSATKYLGGHSDVVGGLVVTASKELGEELHFVQNSTGGVLGPQDSWLLMRGIKTLGLR 248
Query: 260 FERQSENAMAIAEFLKDHPKVREVHYPGLKDDPYYKVARRLFKKDLYGGVVAFDLGSGDN 319
E +NA IA FL++HP V+ ++YPG + P +++A+ + +GG+++FD+GS +
Sbjct: 249 MEAIDQNARKIASFLENHPAVQTLYYPGSSNHPGHELAKT--QGAGFGGMISFDIGSEER 306
Query: 320 ALAFLRGLKRIFPSPSLGGVESIATYPVKSAAKTLDEEIREILGITDGLIRLSVGLEPLD 379
AFL LK + SLG VES+ + P + ++ E R LGITDGLIR+SVG+E +
Sbjct: 307 VDAFLGNLKLFTIAESLGAVESLISVPARMTHASIPRERRLELGITDGLIRISVGIEDAE 366
Query: 380 ELIEDIDNAL 389
+L+EDI AL
Sbjct: 367 DLLEDIGQAL 376
>sp|P56069|METB_HELPY CYSTATHIONINE GAMMA-SYNTHASE (CGS) (O-SUCCINYLHOMOSERINE
(THIOL)-LYASE) >gi|7437084|pir||B64533 cystathionine
gamma-synthase - Helicobacter pylori (strain 26695)
>gi|2313189|gb|AAD07176.1| (AE000532) cystathionine
gamma-synthase (metB) [Helicobacter pylori 26695]
Length = 380
Score = 245 bits (620), Expect = 5e-64
Identities = 141/363 (38%), Positives = 216/363 (58%), Gaps = 10/363 (2%)
Query: 33 PLYITAVFKQVGDAYPTDRGTELKYSREENPTVRKLEDKLAELEGSDNALAFNSGMSAIS 92
P+Y T+ ++Q DA +G E YSR NPT LE+ +A+LEG AF SG++ I
Sbjct: 24 PIYQTSTYRQ--DAIGRHKGYE--YSRSGNPTRFALEELIADLEGGVKGFAFASGLAGIH 79
Query: 93 TLYFSLLEGGDKVVLSMEGYGTTIELA-KLLRKFGVDVKLAYPSADSLIE-TIDEETKLV 150
+ FSLL+ GD V+L + YG T L ++L K G+ + S S I+ I TK +
Sbjct: 80 AV-FSLLQSGDHVLLGDDVYGGTFRLFNQVLVKNGLSCTIIDTSDISQIKKAIKPNTKAL 138
Query: 151 LVETMTNPTLKVIDVPEVAKRCREVGAILVVDNTFVTPLLYKPLEDGASYVVHSLTKYIA 210
+ET +NP LK+ D+ + A ++ G + +VDNTF TP PL GA V HS TKY+
Sbjct: 139 YLETPSNPLLKITDLAQCASVAKDHGLLTIVDNTFATPYYQNPLLLGADIVAHSGTKYLG 198
Query: 211 GHNDVLGGAVLWNGE-FSRDLWEWRRRLGTIIQPFDAWMIERGMRTLEVRFERQSENAMA 269
GH+DV+ G V N E ++++ ++ +G ++ P D+W+++RG++TL +R E +NA+
Sbjct: 199 GHSDVVAGLVTTNNEALAQEIAFFQNAIGGVLGPQDSWLLQRGIKTLGLRMEAHQKNALC 258
Query: 270 IAEFLKDHPKVREVHYPGLKDDPYYKVARRLFKKDLYGGVVAFDLGSGDNALAFLRGLKR 329
+AEFL+ HPKV V+YPGL P Y++A++ + + G+++F L + A+AF+ LK
Sbjct: 259 VAEFLEKHPKVERVYYPGLPTHPNYELAKKQMRG--FSGMLSFTLKNDSEAVAFVESLKL 316
Query: 330 IFPSPSLGGVESIATYPVKSAAKTLDEEIREILGITDGLIRLSVGLEPLDELIEDIDNAL 389
SLGGVES+ P + + RE GI DGL+RLSVG+E +L+ED++ A
Sbjct: 317 FILGESLGGVESLVGIPAFMTHACIPKTQREAAGIRDGLVRLSVGIEHEQDLLEDLEQAF 376
Query: 390 GVV 392
+
Sbjct: 377 AKI 379
>pir||A72595 probable cystathionine gamma-lyase APE1226 - Aeropyrum pernix
(strain K1) >gi|5104901|dbj|BAA80215.1| (AP000061) 384aa
long hypothetical cystathionine gamma-lyase [Aeropyrum
pernix]
Length = 384
Score = 245 bits (618), Expect = 8e-64
Identities = 156/393 (39%), Positives = 232/393 (58%), Gaps = 21/393 (5%)
Query: 6 IKNYVEKDINLPWDQRE---GEIKMKPLHDPLYITAVFKQVGDAYPTDRGTELKYSREEN 62
++ + K ++ D RE G++ + P+H L +T + V +A + G YSR N
Sbjct: 1 MRGFTTKAVHAGEDPRETLHGDV-VHPIH--LSVTYWKRSVAEA---EEG--YVYSRTSN 52
Query: 63 PTVRKLEDKLAELEGSDNALAFNSGMSAISTLYFSLLEGGDKVVLSMEGYGTTIEL-AKL 121
PT LE KLA LE + ALAF+SG++A +T+ +LL GD +V + YG T L ++
Sbjct: 53 PTRDALEKKLAALENARYALAFSSGLAAEATVILALLREGDHIVAFDDLYGGTKRLFQRV 112
Query: 122 LRKFGVDVKLAYPSA---DSLIETIDEETKLVLVETMTNPTLKVIDVPEVAKRCREVGAI 178
+ +FG+ K+ Y A ++ + + T+++ +ET TNP LK+ D+ A+ GA
Sbjct: 113 MARFGI--KVTYVDARDPGNIEKALTPATRMIWLETPTNPLLKLTDIRAAAEIASRAGAY 170
Query: 179 LVVDNTFVTPLLYKPLEDGASYVVHSLTKYIAGHNDVLGGAVLWN-GEFSRDLWEWRRRL 237
LVVDNTF TP +PLE GA VVHS TKY++GH+D+L GAV+ N E L + +
Sbjct: 171 LVVDNTFATPYFQRPLELGADIVVHSATKYLSGHSDLLAGAVMVNSSEVYEKLKYHQNAV 230
Query: 238 GTIIQPFDAWMIERGMRTLEVRFERQSENAMAIAEFLKDHPKVREVHYPGLKDDPYYKVA 297
G + P D++++ R ++TL +R E NAM IAE L+ HPKV V YPGL P + +A
Sbjct: 231 GAVPPPLDSYLLMRSLKTLALRMEWHQHNAMKIAEHLESHPKVDRVIYPGLSTHPQHSLA 290
Query: 298 RRLFKKDLYGGVVAFDL-GSGDNALAFLRGLKRIFPSPSLGGVESIATYPVKSAAKTLDE 356
+R + Y G+++F+L G A+ F+ L+ I + SLGGVES+ P ++
Sbjct: 291 KR--QMTGYSGMLSFELKGGAGAAVRFVESLRIIALAESLGGVESLVEIPSLMTHASIPR 348
Query: 357 EIREILGITDGLIRLSVGLEPLDELIEDIDNAL 389
E R GITDGL+RLSVG+E L++LIEDI+ AL
Sbjct: 349 EERLKKGITDGLVRLSVGIEDLEDLIEDIEQAL 381
>gb|AAF14695.1|AF131881_1 (AF131881) cystathionine beta-lyase MetC [Lactococcus lactis subsp.
cremoris]
Length = 380
Score = 245 bits (618), Expect = 8e-64
Identities = 138/360 (38%), Positives = 214/360 (59%), Gaps = 10/360 (2%)
Query: 33 PLYITAVFKQVGDAYPTDRGTELKYSREENPTVRKLEDKLAELEGSDNALAFNSGMSAIS 92
P+Y T+ +KQ G P E +YSR NPT LE+ +A+LEG AF+SG++ I
Sbjct: 25 PIYQTSTYKQNGLGQPK----EYEYSRSGNPTRHALEELIADLEGGVQGFAFSSGLAGIH 80
Query: 93 TLYFSLLEGGDKVVLSMEGYGTTIELA-KLLRKFGVDVKLA-YPSADSLIETIDEETKLV 150
+ SL GD ++L+ + YG T L K+L K G+ L + + L ETK V
Sbjct: 81 AV-LSLFSAGDHIILADDVYGGTFRLVDKVLTKTGIIYDLVDLSNLEDLKAAFKAETKAV 139
Query: 151 LVETMTNPTLKVIDVPEVAKRCREVGAILVVDNTFVTPLLYKPLEDGASYVVHSLTKYIA 210
ET +NP LKV+D+ E++ + A+ +VDNTF TP L +P+ GA V+HS TKY+
Sbjct: 140 YFETPSNPLLKVLDIKEISSIAKAHNALTLVDNTFATPYLQQPIALGADIVLHSATKYLG 199
Query: 211 GHNDVLGGAVLWN-GEFSRDLWEWRRRLGTIIQPFDAWMIERGMRTLEVRFERQSENAMA 269
GH+DV+ G V N E + ++ + +G ++ P D+W+++RG++TL R E S NA
Sbjct: 200 GHSDVVAGLVTTNSNELAIEIGFLQNSIGAVLGPQDSWLVQRGIKTLAPRMEAHSANAQK 259
Query: 270 IAEFLKDHPKVREVHYPGLKDDPYYKVARRLFKKDLYGGVVAFDLGSGDNALAFLRGLKR 329
IAEFL+ V +V+YPGL + +++A++ + +GG+++F+L + F+ L+
Sbjct: 260 IAEFLEASQAVSKVYYPGLVNHEGHEIAKK--QMTAFGGMISFELTDENAVKNFVENLRY 317
Query: 330 IFPSPSLGGVESIATYPVKSAAKTLDEEIREILGITDGLIRLSVGLEPLDELIEDIDNAL 389
+ SLGGVES+ P ++ +E+RE +GI DGLIRLSVG+E L++L+ D+ AL
Sbjct: 318 FTLAESLGGVESLIEVPAVMTHASIPKELREEIGIKDGLIRLSVGVEALEDLLTDLKEAL 377
>pir||D75458 trans-sulfuration enzyme - Deinococcus radiodurans (strain R1)
>gi|6458644|gb|AAF10498.1|AE001945_2 (AE001945)
trans-sulfuration enzyme [Deinococcus radiodurans]
Length = 392
Score = 243 bits (615), Expect = 2e-63
Identities = 158/368 (42%), Positives = 214/368 (57%), Gaps = 11/368 (2%)
Query: 33 PLYITAVFKQVGDAYPTDR---GTELK--YSREENPTVRKLEDKLAELEGSDNALAFNSG 87
P+Y T+ F GDA R G E YSR NPTVR E+KLA LEG+++ALAF SG
Sbjct: 28 PIYATSTFGY-GDAARGQRLFAGEEQGHFYSRLSNPTVRAFEEKLASLEGTEDALAFASG 86
Query: 88 MSAISTLYFSLLEGGDKVVLSMEGYGTTIELAK-LLRKFGVDVKLAYPSADSLIETIDEE 146
M A S + +LL GD+V YG T L + +L KFG+ V A AD L + +
Sbjct: 87 MGAASAILLTLLRSGDEVAFLAPLYGGTEGLLQDMLPKFGIRVWEAKDPAD-LRGRLTDR 145
Query: 147 TKLVLVETMTNPTLKVIDVPEVAKRCREVGAILVVDNTFVTPLLYKPLEDGASYVVHSLT 206
T+LV +ET +NPTL++ D+ EVA GA LVVDNTF TP L +P E GA V+HS T
Sbjct: 146 TRLVWLETPSNPTLRLTDLREVADLAHGAGARLVVDNTFSTPYLTRPAEFGADLVMHSAT 205
Query: 207 KYIAGHNDVLGGAVLWNGEFSRDL-WEWRRRLGTIIQPFDAWMIERGMRTLEVRFERQSE 265
KY+ GH DV+GG V + DL R +G + PF+A+++ RGM+TL +R E
Sbjct: 206 KYLGGHGDVIGGVVAGDAATLLDLRLHGLRHVGASLGPFEAYLLLRGMKTLPLRMEAHCA 265
Query: 266 NAMAIAEFLKDHPKVREVHYPGLKDDPYYKVARRLFKKDLYGGVVAFDLGSGDNALAFLR 325
A IAE L ++ V+YPGL + P + +ARR +GG+V+ DLG A FL
Sbjct: 266 GAHLIAERLAARGDLK-VYYPGLPEHPGHDLARRQM-SGRFGGIVSLDLGDFAAAQQFLD 323
Query: 326 GLKRIFPSPSLGGVESIATYPVKSAAKTLDEEIREILGITDGLIRLSVGLEPLDELIEDI 385
L+ + SLG VES++++P + + L EE+ GI GL+RLSVG+E ++L DI
Sbjct: 324 ALQLFTQAVSLGDVESLSSHPASTTHQLLGEEVLNAHGIVPGLVRLSVGIEDPEDLWADI 383
Query: 386 DNALGVVR 393
+ AL R
Sbjct: 384 EQALRQAR 391
>gb|AAG19260.1| (AE005022) cystathionine gamma-synthase; Cgs [Halobacterium sp.
NRC-1]
Length = 405
Score = 240 bits (606), Expect = 2e-62
Identities = 136/343 (39%), Positives = 204/343 (58%), Gaps = 8/343 (2%)
Query: 57 YSREENPTVRKLEDKLAELEGSDNALAFNSGMSAISTLYFSLLEGGDKVVLSMEGYGTTI 116
YSR NPT LE +LA LEG D+ AF SG +AI+T F+ +E GD VV + Y T
Sbjct: 59 YSRLNNPTRHALERRLAALEGGDHGFAFGSGTAAIATAAFAAVEPGDHVVAFDDLYAGTR 118
Query: 117 ELAKLLRKFGVDVKLAYPSA---DSLIETIDEETKLVLVETMTNPTLKVIDVPEVAKRCR 173
+ + L + + V +++ A D++ + I ET V +ET TNP +K+ D+ +A
Sbjct: 119 RMLETLFEGNLGVAVSFVDATDPDAVADAIRPETAFVWMETPTNPRIKLCDIAAIADITD 178
Query: 174 EVGAILVVDNTFVTPLLYKPLEDGASYVVHSLTKYIAGHNDVLGGAVLWNGEFSRDLWEW 233
+ G + VDNTF++P +PL GA V HS TKY+ GH+D +GGA++ N + D E+
Sbjct: 179 DAGVLFGVDNTFLSPYFQQPLALGADVVAHSTTKYLNGHSDAVGGALVTNNDALADSVEF 238
Query: 234 RRR--LGTIIQPFDAWMIERGMRTLEVRFERQSENAMAIAEFLKDHPKVREVHYPGLKDD 291
++ LG ++ PFDA+++ RG++TL R NA+AIAE+L DH +V VHYPGL
Sbjct: 239 LQQVGLGNMLAPFDAYLVLRGIKTLAPRMRDHEANALAIAEYLADHDRVTAVHYPGLDSH 298
Query: 292 PYYKVARRLFKKDLYGGVVAFDL-GSGDNALAFLRGLKRIFPSPSLGGVESIATYPVKSA 350
P + +A ++ YGG+++F+L G +A FL L + S+GGVES+ P
Sbjct: 299 PQHDLADA--QQSGYGGILSFELDGDLADAKRFLDALDEFNLAVSVGGVESLVELPAGMT 356
Query: 351 AKTLDEEIREILGITDGLIRLSVGLEPLDELIEDIDNALGVVR 393
+ + + RE +GITD LIR+SVG+E +++LI D+D VR
Sbjct: 357 HEPIPKPDREAMGITDSLIRVSVGIEAIEDLIADLDRGFEAVR 399
>sp|Q9ZMW7|METB_HELPJ CYSTATHIONINE GAMMA-SYNTHASE (CGS) (O-SUCCINYLHOMOSERINE
(THIOL)-LYASE) >gi|7437091|pir||D71973 probable
cystathionine gamma-synthase - Helicobacter pylori
(strain J99) >gi|4154605|gb|AAD05677.1| (AE001449)
putative CYSTATHIONINE GAMMA-SYNTHASE [Helicobacter
pylori J99]
Length = 380
Score = 234 bits (590), Expect = 2e-60
Identities = 138/363 (38%), Positives = 209/363 (57%), Gaps = 10/363 (2%)
Query: 33 PLYITAVFKQVGDAYPTDRGTELKYSREENPTVRKLEDKLAELEGSDNALAFNSGMSAIS 92
P+Y T+ ++Q DA +G E YSR NPT LE+ +A+LEG AF SG++ I
Sbjct: 24 PIYQTSTYRQ--DAIGRHKGYE--YSRSGNPTRFALEELIADLEGGVKGFAFASGLAGIH 79
Query: 93 TLYFSLLEGGDKVVLSMEGYGTTIELA-KLLRKFGVDVKLAYPSADSLIE-TIDEETKLV 150
+ FSLL+ GD V+L + YG L K+L K G+ + S S I+ I TK +
Sbjct: 80 AV-FSLLQSGDHVLLGDDVYGGNFRLFNKVLVKNGLSCTIIDTSDLSQIKKAIKPNTKAL 138
Query: 151 LVETMTNPTLKVIDVPEVAKRCREVGAILVVDNTFVTPLLYKPLEDGASYVVHSLTKYIA 210
+ET +NP LK+ D+ + A +E + +VDNTF TP PL G V H+ TKY+
Sbjct: 139 YLETPSNPLLKITDLAQCASVAKEHNLLTIVDNTFATPYCQNPLLLGTDIVAHNGTKYLG 198
Query: 211 GHNDVLGGAVLWNGE-FSRDLWEWRRRLGTIIQPFDAWMIERGMRTLEVRFERQSENAMA 269
GH+DV+ G V N E +++ ++ +G ++ D+W+++RG++TL +R E +NA+
Sbjct: 199 GHSDVVAGLVTTNNEALAQEFDFFQNAIGGVLGLQDSWLLQRGIKTLGLRMEAHQKNALC 258
Query: 270 IAEFLKDHPKVREVHYPGLKDDPYYKVARRLFKKDLYGGVVAFDLGSGDNALAFLRGLKR 329
+AEFL+ HPKV V+YPGL P +++A+ + + G+ +F L + A+AF+ LK
Sbjct: 259 VAEFLEKHPKVERVYYPGLPTHPNHELAKAQMRG--FSGMFSFTLKNDSEAVAFVESLKL 316
Query: 330 IFPSPSLGGVESIATYPVKSAAKTLDEEIREILGITDGLIRLSVGLEPLDELIEDIDNAL 389
SLGGVES+ P + + RE GI DGL+RLSVG+E +L+ED+D A
Sbjct: 317 FILGESLGGVESLVGIPALMTHACIPKAQREAAGIRDGLVRLSVGIEHEQDLLEDLDQAF 376
Query: 390 GVV 392
+
Sbjct: 377 AKI 379
>dbj|BAB04518.1| (AP001509) methionine gamma lyase [Bacillus halodurans]
Length = 393
Score = 233 bits (589), Expect = 2e-60
Identities = 135/369 (36%), Positives = 218/369 (58%), Gaps = 12/369 (3%)
Query: 30 LHDPLYITAVF-----KQVGDAYPTDRGTELKYSREENPTVRKLEDKLAELEGSDNALAF 84
L P+Y T+ F +Q G+ + + + YSR NPTV+ LE ++AELEG + ALAF
Sbjct: 25 LTPPIYQTSTFTFASMEQGGNRFAGEEAGYV-YSRLGNPTVQILEQRIAELEGGEAALAF 83
Query: 85 NSGMSAISTLYFSLLEGGDKVVLSMEGYGTTIELAKLLR-KFGVDVKLA-YPSADSLIET 142
SGM+A+S + L + D +++S YG T L +L+ K+ +D + S + ++
Sbjct: 84 GSGMAAVSAILVGLTKANDHILVSNGVYGCTFGLLTMLKEKYNIDATFSPMDSVEEILAN 143
Query: 143 IDEETKLVLVETMTNPTLKVIDVPEVAKRCREVGAILVVDNTFVTPLLYKPLEDGASYVV 202
I + T + VET NPT+++ID+ V + +E G ++VDNTF TP L +P+ G +VV
Sbjct: 144 IQDNTTCIYVETPINPTMQLIDLELVVRVAKEKGIKVIVDNTFATPYLQQPIALGCDFVV 203
Query: 203 HSLTKYIAGHNDVLGGAVLWNGEFSRDLWEWRRR-LGTIIQPFDAWMIERGMRTLEVRFE 261
HS TKYI GH DV+ G ++ + E + + + ++ +G +I PFDAW++ RG++TL VR +
Sbjct: 204 HSATKYIGGHGDVVAGVLIGDKETIQLIRKTTQKDMGGVISPFDAWLLLRGLKTLAVRMD 263
Query: 262 RQSENAMAIAEFLKDHPKVREVHYPGLKDDPYYKVARRLFKKDLYGGVVAFDL-GSGDNA 320
R ENA +AE LK+HPKV V YPG + P + + + KK GG+++F++ G+ +
Sbjct: 264 RHCENAEKLAEKLKEHPKVSTVLYPGDFEHPDHSIVAKQMKKG--GGLLSFEIKGTEADI 321
Query: 321 LAFLRGLKRIFPSPSLGGVESIATYPVKSAAKTLDEEIREILGITDGLIRLSVGLEPLDE 380
+ LK I + SLG E++ +P + E+ R +GI+ L+R+S GLE +
Sbjct: 322 AKVVNQLKLIRIAVSLGDAETLIQHPATMTHAVVPEKRRTQMGISKKLLRMSAGLEAWQD 381
Query: 381 LIEDIDNAL 389
+ D++ AL
Sbjct: 382 VWADLEQAL 390
>dbj|BAB05347.1| (AP001512) cystathionine beta-lyase [Bacillus halodurans]
Length = 390
Score = 233 bits (589), Expect = 2e-60
Identities = 138/340 (40%), Positives = 202/340 (58%), Gaps = 6/340 (1%)
Query: 57 YSREENPTVRKLEDKLAELEGSDNALAFNSGMSAISTLYFSLLEGGDKVVLSMEGYGTTI 116
YSR NPT LE +AELEG ++ AF SGM+AIST F LL GD VVL+ + YG T
Sbjct: 48 YSRSGNPTRDALEAAIAELEGGNHGFAFASGMAAISTA-FMLLSKGDHVVLTKDVYGGTF 106
Query: 117 ELA-KLLRKFGVDVKLA-YPSADSLIETIDEETKLVLVETMTNPTLKVIDVPEVAKRCRE 174
L ++L + G++ + + I T+++ +ET +NPTL + D+ V +E
Sbjct: 107 RLVTEVLTRLGIEHTFVDMTNLAEVAAAIRPNTRVLYMETPSNPTLNITDIRGVVSLAKE 166
Query: 175 VGAILVVDNTFVTPLLYKPLEDGASYVVHSLTKYIAGHNDVLGG-AVLWNGEFSRDLWEW 233
+ +DNTF+TP L +PLE G V+HS TK+I GH+DV+ G AV N E + L
Sbjct: 167 HECLTFLDNTFLTPALQRPLELGVDVVLHSATKFIGGHSDVVAGLAVTKNEELGKKLAFL 226
Query: 234 RRRLGTIIQPFDAWMIERGMRTLEVRFERQSENAMAIAEFLKDHPKVREVHYPGLKDDPY 293
+ G I+ D W++ RG++TL VR E + A IAE+L+ P+V+ V+YPGLKD P
Sbjct: 227 QNSFGAILGVQDVWLVLRGLKTLHVRMEHGEKGAQQIAEWLQGVPEVKRVYYPGLKDHPG 286
Query: 294 YKVARRLFKKDLYGGVVAFDLGSGDNALAFLRGLKRIFPSPSLGGVESIATYPVKSAAKT 353
+++ +R + + +G V++F+L + + F+ +K + SLG VESI +YP K +
Sbjct: 287 HELQKR--QAEGFGAVLSFELENEEAVRRFVEHVKLPVFAVSLGAVESILSYPAKMSHAA 344
Query: 354 LDEEIREILGITDGLIRLSVGLEPLDELIEDIDNALGVVR 393
+ +E RE GI DGL+RLSVGLE +EL+ D A VR
Sbjct: 345 MPKEEREARGIRDGLLRLSVGLEKPEELMADFKAAFAHVR 384
>emb|CAA04124.1| (AJ000486) methionine gamma-lyase [Trichomonas vaginalis]
Length = 396
Score = 233 bits (589), Expect = 2e-60
Identities = 139/368 (37%), Positives = 209/368 (56%), Gaps = 14/368 (3%)
Query: 33 PLYITAVF-----KQVGDAYPTDRGTELKYSREENPTVRKLEDKLAELEGSDNALAFNSG 87
P+Y T+ F +Q G+ + + Y+R NPTV LE K+A LE ++ +A +SG
Sbjct: 28 PIYQTSTFVFDNCQQGGNRFAGQESGYI-YTRLGNPTVSNLEGKIAFLEKTEACVATSSG 86
Query: 88 MSAISTLYFSLLEGGDKVVLSMEGYGTTIELAK-LLRKFGVDVKLAYPSADSLIET-IDE 145
M AI+ ++L+ GD ++ YG T L + L KFG+ V + ++ +
Sbjct: 87 MGAIAATVLTILKAGDHLISDECLYGCTHALFEHALTKFGIQVDFINTAIPGEVKKHMKP 146
Query: 146 ETKLVLVETMTNPTLKVIDVPEVAKRCR-EVGAILVVDNTFVTPLLYKPLEDGASYVVHS 204
TK+V ET NPTLK+ID+ V K + G +++ DNTF +P++ P++ G VVHS
Sbjct: 147 NTKIVYFETPANPTLKIIDMERVCKDAHSQEGVLVIADNTFCSPMITNPVDFGVDVVVHS 206
Query: 205 LTKYIAGHNDVLGGAVLWNGEFSRDLWEWRRR--LGTIIQPFDAWMIERGMRTLEVRFER 262
TKYI GH DV+ G + + + + + G++I P DAW+I RG+ TL +R +
Sbjct: 207 ATKYINGHTDVVAGLICGKADLLQQIRMVGIKDITGSVISPHDAWLITRGLSTLNIRMKA 266
Query: 263 QSENAMAIAEFLKDHPKVREVHYPGLKDDPYYKVARRLFKKDLYGGVVAFDLGSG-DNAL 321
+SENAM +AE+LK HP V +V+YPG +D + +A++ + + G ++ F L SG + A
Sbjct: 267 ESENAMKVAEYLKSHPAVEKVYYPGFEDHEGHDIAKKQMR--MSGSMITFILKSGFEGAK 324
Query: 322 AFLRGLKRIFPSPSLGGVESIATYPVKSAAKTLDEEIREILGITDGLIRLSVGLEPLDEL 381
L LK I + SLGG ES+ +P + +E RE GITDG+IRLSVG+E DEL
Sbjct: 325 KLLDNLKLITLAVSLGGCESLIQHPASMTHAVVPKEEREAAGITDGMIRLSVGIEDADEL 384
Query: 382 IEDIDNAL 389
I D L
Sbjct: 385 IADFKQGL 392
>pir||A69847 cystathionine gamma-synthase homolog yjcI - Bacillus subtilis
>gi|2633541|emb|CAB13044.1| (Z99110) similar to
cystathionine gamma-synthase [Bacillus subtilis]
Length = 373
Score = 233 bits (588), Expect = 3e-60
Identities = 133/364 (36%), Positives = 206/364 (56%), Gaps = 26/364 (7%)
Query: 33 PLYITAVFKQVGDAYPTDRGTELKYSREENPTVRKLEDKLAELEGSDNALAFNSGMSAIS 92
P+Y++ ++ G T Y R +NPT + +ED +A LE LAF+SGM+AI
Sbjct: 26 PIYLSTAYRHRG----IGESTGFDYVRTKNPTRQLVEDAIANLENGARGLAFSSGMAAIQ 81
Query: 93 TLYFSLLEGGDKVVLSMEGYGTTIELAKL-LRKFGVDVKLA-YPSADSLIETIDEETKLV 150
T+ +L + GD++++S + YG T L + +K+G+ + D L I TK V
Sbjct: 82 TI-MALFKSGDELIVSSDLYGGTYRLFENEWKKYGLTFHYDDFSDEDCLRSKITPNTKAV 140
Query: 151 LVETMTNPTLKVIDVPEVAKRCREVGAILVVDNTFVTPLLYKPLEDGASYVVHSLTKYIA 210
VET TNP ++ D+ +A+ +E G +L+VDNTF TP+L +PLE GA V+HS TKY+
Sbjct: 141 FVETPTNPLMQEADIEHIARITKEHGLLLIVDNTFYTPVLQRPLELGADIVIHSATKYLG 200
Query: 211 GHNDVLGGAVLWNGE-FSRDLWEWRRRLGTIIQPFDAWMIERGMRTLEVRFERQSENAMA 269
GHND+L G V+ E ++++ + +G ++ PFD+W++ RGM+TL +R + NA
Sbjct: 201 GHNDLLAGLVVVKDERLGEEMFQHQNAIGAVLPPFDSWLLMRGMKTLSLRMRQHQANAQE 260
Query: 270 IAEFLKDHPKVREVHYPGLKDDPYYKVARRLFKKDLYGGVVAFDLGSGDNALAFLRGLKR 329
+A FL++ ++ +V YPG GG+++F L + FL+ LK
Sbjct: 261 LAAFLEEQEEISDVLYPG------------------KGGMLSFRLQKEEWVNPFLKALKT 302
Query: 330 IFPSPSLGGVESIATYPVKSAAKTLDEEIREILGITDGLIRLSVGLEPLDELIEDIDNAL 389
I + SLGGVES TYP + EEIR G+ + L+R SVG+E ++L ED+ AL
Sbjct: 303 ICFAESLGGVESFITYPATQTHMDIPEEIRIANGVCNRLLRFSVGIEHAEDLKEDLKQAL 362
Query: 390 GVVR 393
V+
Sbjct: 363 CQVK 366
>emb|CAA04125.1| (AJ000487) methionine gamma-lyase [Trichomonas vaginalis]
Length = 398
Score = 232 bits (586), Expect = 5e-60
Identities = 144/369 (39%), Positives = 209/369 (56%), Gaps = 11/369 (2%)
Query: 33 PLYITAVFK----QVGDAYPTDRGTELKYSREENPTVRKLEDKLAELEGSDNALAFNSGM 88
P+Y T+ F G A + Y+R NPT LE K+A+LE ++ A SGM
Sbjct: 31 PIYQTSTFLFDNCDQGGARFGGKEAGYMYTRIGNPTNSALEGKIAKLEHAEACAATASGM 90
Query: 89 SAISTLYFSLLEGGDKVVLSMEGYGTTIELAK-LLRKFGVDVKLAYPSADSLIET-IDEE 146
AI+ ++ L+ GD ++ YG T L + LRKFGV+V + IE +
Sbjct: 91 GAIAASVWTFLKAGDHLISDDCLYGCTHALFEHQLRKFGVEVDFIDMAVPGNIEKHLKPN 150
Query: 147 TKLVLVETMTNPTLKVIDVPEVAKRCREVGAILV-VDNTFVTPLLYKPLEDGASYVVHSL 205
T++V ET NPTLKVID+ + K+ R+ ILV VDNTF +P+L PL+ G VVHS
Sbjct: 151 TRIVYFETPANPTLKVIDIEDAVKQARKQKDILVIVDNTFASPILTNPLDLGVDIVVHSA 210
Query: 206 TKYIAGHNDVLGGAVLWNGEFSRDLWEWRRR--LGTIIQPFDAWMIERGMRTLEVRFERQ 263
TKYI GH DV+ G V + + + G II P DAW+I RG TL++R +R
Sbjct: 211 TKYINGHTDVVAGLVCSRADIIAKVKSQGIKDITGAIISPHDAWLITRGTLTLDMRVKRA 270
Query: 264 SENAMAIAEFLKDHPKVREVHYPGLKDDPYYKVARRLFKKDLYGGVVAFDLGSGDNALAF 323
+ENA +AEFL +H V++V+YPGL D P +++A++ K ++G ++AFD+ + A
Sbjct: 271 AENAQKVAEFLHEHKAVKKVYYPGLPDHPGHEIAKKQMK--MFGSMIAFDVDGLEKAKKV 328
Query: 324 LRGLKRIFPSPSLGGVESIATYPVKSAAKTLDEEIREILGITDGLIRLSVGLEPLDELIE 383
L + + SLGG ES+ +P + +E RE G+TD LIRLSVG E + ++I+
Sbjct: 329 LDNCHVVSLAVSLGGPESLIQHPASMTHAGVPKEEREAAGLTDNLIRLSVGCENVQDIID 388
Query: 384 DIDNALGVV 392
D+ AL +V
Sbjct: 389 DLKQALDLV 397
>pir||E82752 cystathionine gamma-synthase XF0864 [imported] - Xylella fastidiosa
(strain 9a5c) >gi|9105774|gb|AAF83674.1|AE003926_3
(AE003926) cystathionine gamma-synthase [Xylella
fastidiosa]
Length = 405
Score = 231 bits (583), Expect = 1e-59
Identities = 137/341 (40%), Positives = 201/341 (58%), Gaps = 12/341 (3%)
Query: 57 YSREENPTVRKLEDKLAELEGSDNALAFNSGMSAISTLYFSLLEGGDKVVLSMEGYGTTI 116
Y+R NPT L + LAELEG + +G++AI + +LL GD++V+ + YG +
Sbjct: 54 YTRSANPTRDLLGEALAELEGGVGGVVTATGIAAIMLVLHALLRPGDRLVVPHDAYGGSW 113
Query: 117 ELAKLLRKFG----VDVKLAYPSADSLIETIDEETKLVLVETMTNPTLKVIDVPEVAKRC 172
L L + G + V L A S++E + KLVL+ET +NP L++ D+ V +
Sbjct: 114 RLFNALAQKGHFELITVDLT--DARSVVEALALPPKLVLIETPSNPLLRITDLGAVIEAA 171
Query: 173 REVGAILVVDNTFVTPLLYKPLEDGASYVVHSLTKYIAGHNDVLGGAVLWN--GEFSRDL 230
VGA+ VVDNTF++P+L +PLE GA V+HS TKYI GH+DV+GG V+ + + +
Sbjct: 172 HRVGALTVVDNTFMSPVLQRPLEFGADLVLHSTTKYINGHSDVVGGVVVARDVAHYQQLV 231
Query: 231 WEWRRRLGTIIQPFDAWMIERGMRTLEVRFERQSENAMAIAEFLKDHPKVREVHYPGLKD 290
W W LG PFDA++ RG+RTL+ R ENA IA L+ H V+ VHYPGL
Sbjct: 232 W-WANALGLTGSPFDAFLTLRGVRTLDARLRVHQENAQMIAALLEGHGVVKHVHYPGLAS 290
Query: 291 DPYYKVARRLFKKDLYGGVVAFDLGSGDNAL-AFLRGLKRIFPSPSLGGVESIATYPVKS 349
P + +A R K +G +++F+L G+ A+ AF+ GL+ + SLGGVES+ +P
Sbjct: 291 HPGHVLAGRQQKG--FGAMLSFELQGGEAAVRAFVSGLRYFTLAESLGGVESLIAHPASM 348
Query: 350 AAKTLDEEIREILGITDGLIRLSVGLEPLDELIEDIDNALG 390
+ + R GI+DGL+RLSVG+E ++LI D+ LG
Sbjct: 349 THAAMTPQARAKAGISDGLLRLSVGIEASEDLIVDLVAGLG 389
>pir||B69847 cystathionine beta-lyase homolog yjcJ - Bacillus subtilis
>gi|2633542|emb|CAB13045.1| (Z99110) similar to
cystathionine beta-lyase [Bacillus subtilis]
Length = 390
Score = 231 bits (582), Expect = 1e-59
Identities = 128/336 (38%), Positives = 200/336 (59%), Gaps = 6/336 (1%)
Query: 57 YSREENPTVRKLEDKLAELEGSDNALAFNSGMSAISTLYFSLLEGGDKVVLSMEGYGTTI 116
YSR PT LE+ +A LEG AF+SGM+AIST F LL GD V+++ + YG T
Sbjct: 49 YSRSGTPTRTALEETIAALEGGTRGFAFSSGMAAISTA-FLLLSQGDHVLVTEDVYGGTF 107
Query: 117 ELA-KLLRKFGVDVKLA-YPSADSLIETIDEETKLVLVETMTNPTLKVIDVPEVAKRCRE 174
+ ++L +FG++ + + +I TK++ +ET +NPTL + D+ V + +E
Sbjct: 108 RMVTEVLTRFGIEHTFVDMTDRNEVARSIKPNTKVIYMETPSNPTLGITDIKAVVQLAKE 167
Query: 175 VGAILVVDNTFVTPLLYKPLEDGASYVVHSLTKYIAGHNDVLGG-AVLWNGEFSRDLWEW 233
G + +DNTF+TP L +PL+ G V+HS TK+++GH+DVL G A + + E + L++
Sbjct: 168 NGCLTFLDNTFMTPALQRPLDLGVDIVLHSATKFLSGHSDVLSGLAAVKDEELGKQLYKL 227
Query: 234 RRRLGTIIQPFDAWMIERGMRTLEVRFERQSENAMAIAEFLKDHPKVREVHYPGLKDDPY 293
+ G ++ D W++ RG++TL+VR E+ S+ A +AEF + HP V+ V+YPGL D P
Sbjct: 228 QNAFGAVLGVQDCWLVLRGLKTLQVRLEKASQTAQRLAEFFQKHPAVKRVYYPGLADHPG 287
Query: 294 YKVARRLFKKDLYGGVVAFDLGSGDNALAFLRGLKRIFPSPSLGGVESIATYPVKSAAKT 353
+ + + G V++F+L S + + + + SLG VESI +YP +
Sbjct: 288 AETHKS--QSTGAGAVLSFELESKEAVKKLVENVSLPVFAVSLGAVESILSYPATMSHAA 345
Query: 354 LDEEIREILGITDGLIRLSVGLEPLDELIEDIDNAL 389
+ +E RE GITDGL+RLSVG+E D+L D + AL
Sbjct: 346 MPKEEREKRGITDGLLRLSVGVEHADDLEHDFEQAL 381
>pir||T47234 O-succinylhomoserine (thiol)-lyase (EC 4.2.99.9) [validated] -
Corynebacterium glutamicum
>gi|5852462|gb|AAD54070.1|AF126953_1 (AF126953)
cystathionine gamma-synthase [Corynebacterium
glutamicum]
Length = 386
Score = 229 bits (577), Expect = 5e-59
Identities = 139/364 (38%), Positives = 207/364 (56%), Gaps = 12/364 (3%)
Query: 30 LHDPLYITAVFKQVGDAYPTDRGTELKYSREENPTVRKLEDKLAELEGSDNALAFNSGMS 89
++ P+Y + F Q P + +Y+R NPT+ LE +A LEG+ AF+SGM+
Sbjct: 28 INTPIYASTTFAQNA---PNELRKGYEYTRVGNPTIVALEQTVAALEGAKYGRAFSSGMA 84
Query: 90 AISTLYFSLLEGGDKVVLSMEGYGTTIELAK-LLRKFGVDVKLAYPSA-DSLIETIDEET 147
A L+ +L+ GD +VL + YG T L + +GV+ + S + + I + T
Sbjct: 85 ATDILFRIILKPGDHIVLGNDAYGGTYRLIDTVFTAWGVEYTVVDTSVVEEVKAAIKDNT 144
Query: 148 KLVLVETMTNPTLKVIDVPEVAKRCREVGAILVVDNTFVTPLLYKPLEDGASYVVHSLTK 207
KL+ VET TNP L + D+ VAK A LVVDNTF +P L +PL+ GA V+HS TK
Sbjct: 145 KLIWVETPTNPALGITDIEAVAKLTEGTNAKLVVDNTFASPYLQQPLKLGAHAVLHSTTK 204
Query: 208 YIAGHNDVLGGAVLWNG-EFSRDLWEWRRRLGTIIQPFDAWMIERGMRTLEVRFERQSEN 266
YI GH+DV+GG V+ N E +L + +G I FDA++ RG++TL VR +R +N
Sbjct: 205 YIGGHSDVVGGLVVTNDQEMDEELLFMQGGIGPIPSVFDAYLTARGLKTLAVRMDRHCDN 264
Query: 267 AMAIAEFLKDHPKVREVHYPGLKDDPYYKVARRLFKKDLYGGVVAFDLGSGDNAL-AFLR 325
A IAEFL P+V V YPGLK+ P ++VA + K+ +GG+++ G+ A F
Sbjct: 265 AEKIAEFLDSRPEVSTVLYPGLKNHPGHEVAAKQMKR--FGGMISVRFAGGEEAAKKFCT 322
Query: 326 GLKRIFPSPSLGGVESIATYPVKSAAKTLDEEIREILGITDGLIRLSVGLEPLDELIEDI 385
K I + SLGGVES+ +P A T L + L+R+S+G+E +++L+ D+
Sbjct: 323 STKLICLAESLGGVESLLEHP---ATMTHQSAAGSQLEVPRDLVRISIGIEDIEDLLADV 379
Query: 386 DNAL 389
+ AL
Sbjct: 380 EQAL 383
>gi|6319307 cystathionine gamma-lyase; Cys3p [Saccharomyces cerevisiae]
>gi|399331|sp|P31373|CYS3_YEAST CYSTATHIONINE
GAMMA-LYASE (GAMMA-CYSTATHIONASE) >gi|320654|pir||S31228
cystathionine gamma-lyase (EC 4.4.1.1) - yeast
(Saccharomyces cerevisiae) >gi|171863|gb|AAC04945.1|
(L05146) Cys3p: cystathionine gamma-lyase [Saccharomyces
cerevisiae] >gi|416164|dbj|BAA03190.1| (D14135)
cystathionine gammma-lyase [Saccharomyces cerevisiae]
Length = 394
Score = 229 bits (577), Expect = 5e-59
Identities = 143/365 (39%), Positives = 202/365 (55%), Gaps = 10/365 (2%)
Query: 32 DPLYITAVFKQVGDAYPTDRGTELKYSREENPTVRKLEDKLAELEGSDNALAFNSGMSAI 91
+P+ ++ FKQ A P GT +YSR +NP LE +A LE + LAF+SG +
Sbjct: 28 EPISLSTTFKQSSPANPI--GT-YEYSRSQNPNRENLERAVAALENAQYGLAFSSGSATT 84
Query: 92 STLYFSLLEGGDKVVLSMEGYGTTIELAKLLRKFGVDVKLAYPSADSLIETIDEETKLVL 151
+T+ SL +G V + GT K+ GV+ + L + I E TKLV
Sbjct: 85 ATILQSLPQGSHAVSIGDVYGGTHRYFTKVANAHGVETSFTNDLLNDLPQLIKENTKLVW 144
Query: 152 VETMTNPTLKVIDVPEVAKRCREVGA----ILVVDNTFVTPLLYKPLEDGASYVVHSLTK 207
+ET TNPTLKV D+ +VA ++ A ILVVDNTF++P + PL GA VVHS TK
Sbjct: 145 IETPTNPTLKVTDIQKVADLIKKHAAGQDVILVVDNTFLSPYISNPLNFGADIVVHSATK 204
Query: 208 YIAGHNDVLGGAVLWNGE-FSRDLWEWRRRLGTIIQPFDAWMIERGMRTLEVRFERQSEN 266
YI GH+DV+ G + N + L + +G I PFDAW+ RG++TL +R + + +
Sbjct: 205 YINGHSDVVLGVLATNNKPLYERLQFLQNAIGAIPSPFDAWLTHRGLKTLHLRVRQAALS 264
Query: 267 AMAIAEFL-KDHPKVREVHYPGLKDDPYYKVARRLFKKDLYGGVVAFDLGSGDNALAFLR 325
A IAEFL D V V+YPGLK P Y V + + L GG+++F + G A +
Sbjct: 265 ANKIAEFLAADKENVVAVNYPGLKTHPNYDVVLKQHRDALGGGMISFRIKGGAEAASKFA 324
Query: 326 GLKRIFP-SPSLGGVESIATYPVKSAAKTLDEEIREILGITDGLIRLSVGLEPLDELIED 384
R+F + SLGG+ES+ P + +E RE G+ D L+R+SVG+E D+L+ED
Sbjct: 325 SSTRLFTLAESLGGIESLLEVPAVMTHGGIPKEAREASGVFDDLVRISVGIEDTDDLLED 384
Query: 385 IDNAL 389
I AL
Sbjct: 385 IKQAL 389
>dbj|BAB04261.1| (AP001508) cystathionine gamma-synthase [Bacillus halodurans]
Length = 381
Score = 228 bits (576), Expect = 7e-59
Identities = 140/391 (35%), Positives = 215/391 (54%), Gaps = 22/391 (5%)
Query: 5 RIKNYVEKDINLPWDQREGEI-KMKPLHDPLYITA--VFKQVGDAYPTDRGT-ELKYSRE 60
R K + K ++ E EI K + P+Y T+ VF+ + D RG E Y+R
Sbjct: 2 REKKFATKSVHFT----EKEISKNRSKSKPIYQTSAFVFQDLDDMESFYRGEKEYLYTRY 57
Query: 61 ENPTVRKLEDKLAELEGSDNALAFNSGMSAISTLYFSLLEGGDKVVLSMEGYGTTIEL-A 119
NP L +A LE +++ +A ++GMSAI +LLE GD ++ + + YG T +L A
Sbjct: 58 GNPNSDDLGKGVASLEQAEDGVATSAGMSAILVALLALLEKGDHLIAANDLYGGTYQLLA 117
Query: 120 KLLRKFGVDVKLA-YPSADSLIETIDEETKLVLVETMTNPTLKVIDVPEVAKRCREVGAI 178
+ L K G+DV + + + I +ETK++ ET+TNP L+V D+ +V + +E G
Sbjct: 118 EELPKLGIDVSFVPFQEREVVKRAIRKETKVLYSETVTNPLLRVEDIHQVVELGKEHGLS 177
Query: 179 LVVDNTFVTPLLYKPLEDGASYVVHSLTKYIAGHNDVLGGAVLWNGEFSRDLWEWRRRLG 238
V+DNTF TP +PL G VVHS TKYI GH+DV G V+ + E + + + LG
Sbjct: 178 TVIDNTFATPYFVQPLTCGVDVVVHSATKYIGGHSDVTAGVVVGSAEIIQQVRQKVATLG 237
Query: 239 TIIQPFDAWMIERGMRTLEVRFERQSENAMAIAEFLKDHPKVREVHYPGLKDDPYYKVAR 298
+ PF+AW+ RG++TL +R ERQ ENA A+A F DHP V +V YP
Sbjct: 238 CNLSPFEAWLASRGLKTLALRMERQGENAQALATFFADHPGVSQVFYP------------ 285
Query: 299 RLFKKDLYGGVVAFDLGSGDNALAFLRGLKRIFPSPSLGGVESIATYPVKSAAKTLDEEI 358
K G +V L A F L + +P+L GVE+ +YP++++ +T+ E +
Sbjct: 286 TTVSKRGNGAIVTIRLAEKVEAATFFESLDWVKIAPTLAGVETTVSYPIQTSHRTVPESL 345
Query: 359 REILGITDGLIRLSVGLEPLDELIEDIDNAL 389
R+ LGI L+R+SVG+E +++++ D A+
Sbjct: 346 RQELGIDKQLVRISVGIEDIEDIMAAFDKAI 376
>gb|AAG19548.1| (AE005045) cystathionine alpha synthase; MetB [Halobacterium sp.
NRC-1]
Length = 393
Score = 227 bits (572), Expect = 2e-58
Identities = 142/365 (38%), Positives = 210/365 (56%), Gaps = 13/365 (3%)
Query: 30 LHDPLYITAVFKQVGDAYPTD-RGTELKYSREENPTVRKLEDKLAELEGSDNALAFNSGM 88
L P++ + + Q G P D RG E YSR NPT LE LA LEG ++ AF SGM
Sbjct: 32 LMTPIFANSTYVQDG---PGDHRGYE--YSRTGNPTRTDLEANLASLEGGEHGRAFASGM 86
Query: 89 SAISTLYFSLLEGGDKVVLSMEGYGTTIEL-AKLLRKFGVDVKLAYPSA-DSLIETIDEE 146
+AI+T+ +LL GD VV + YG T + ++ + +D + D++ E + E
Sbjct: 87 AAINTV-LNLLAAGDHVVAGDDVYGGTHRIFTQVYEDYDIDFDFVDTTDHDAVREAMGEA 145
Query: 147 TKLVLVETMTNPTLKVIDVPEVAKRCREVGAILVVDNTFVTPLLYKPLEDGASYVVHSLT 206
T+L+ VET TNP L V D+ +A E A+ VDNTF TP L +PLE GA V HSLT
Sbjct: 146 TELLWVETPTNPLLNVNDIGALADIAHEHDALCAVDNTFATPYLQRPLEFGADIVSHSLT 205
Query: 207 KYIAGHNDVLGGAVLW-NGEFSRDLWEWRRRLGTIIQPFDAWMIERGMRTLEVRFERQSE 265
KY+ GH+D++ GA++ + + ++ +G PFD +++ RG +TL VR +R E
Sbjct: 206 KYLGGHSDLVAGALITDDDDLDEQFGFYQNSVGATPSPFDCFLVLRGTKTLGVRMDRHCE 265
Query: 266 NAMAIAEFLKDHPKVREVHYPGLKDDPYYKVARRLFKKDLYGGVVAFDLGSG-DNALAFL 324
AM +A +L DH V +VHYPGL+ P +++A + D +GG+V+F+L + + A AF+
Sbjct: 266 TAMELAAWLADHEHVSQVHYPGLESHPDHELAAA--QMDGFGGMVSFELDATLEAASAFV 323
Query: 325 RGLKRIFPSPSLGGVESIATYPVKSAAKTLDEEIREILGITDGLIRLSVGLEPLDELIED 384
+ SLGGVES+ P + + RE G+TDGLIR S+G+E +D+L D
Sbjct: 324 EETDVFTLAESLGGVESLIEQPAAMTHAAIPKAEREAAGLTDGLIRASIGVEHVDDLKAD 383
Query: 385 IDNAL 389
+ A+
Sbjct: 384 LQQAI 388
>dbj|BAB05346.1| (AP001512) cystathionine gamma-synthase (O-succinylhomoserine
(thiol)-lyase) [Bacillus halodurans]
Length = 378
Score = 226 bits (571), Expect = 3e-58
Identities = 135/377 (35%), Positives = 207/377 (54%), Gaps = 31/377 (8%)
Query: 19 DQREGEIKMKPLHDPLYITAVFKQVGDAYPTDRGTELKYSREENPTVRKLEDKLAELEGS 78
D R G I + P+Y + ++ G T Y+R NPT LE +A LE
Sbjct: 18 DDRTGAI-----NTPVYFSTAYRHSG----IGESTGYDYARTGNPTREVLEKAIATLENG 68
Query: 79 DNALAFNSGMSAISTLYFSLLEGGDKVVLSMEGYGTTIELAKL-LRKFGVDVKLAYP-SA 136
D A +SGM+AI T+ FSL + GD+++ S + YG T L + +K+G+ A P +
Sbjct: 69 DQGFACSSGMAAIQTV-FSLFQSGDEIIASQDLYGGTYRLFEGGWKKWGLSFSYADPRNL 127
Query: 137 DSLIETIDEETKLVLVETMTNPTLKVIDVPEVAKRCREVGAILVVDNTFVTPLLYKPLED 196
+L + I E+T+ + +ET TNP ++ ++ E+A + G +L+VDNTF TPLL +PL +
Sbjct: 128 AALEQQITEKTRALFIETPTNPLMQEANIRELAALANKHGLLLIVDNTFYTPLLQQPLNE 187
Query: 197 GASYVVHSLTKYIAGHNDVLGGAVLWNG-EFSRDLWEWRRRLGTIIQPFDAWMIERGMRT 255
G V+HS +KY+ GHNDV+ G ++ G E + + +G + FD+W++ RGM+T
Sbjct: 188 GTHIVIHSASKYLGGHNDVIAGLIVAKGQELCEQIAYYHNGIGGTLSAFDSWLLIRGMKT 247
Query: 256 LEVRFERQSENAMAIAEFLKDHPKVREVHYPGLKDDPYYKVARRLFKKDLYGGVVAFDLG 315
L +R E+ NA AIA +L+ H V +V YPG GG+++F +
Sbjct: 248 LALRMEQHQNNARAIASYLEKHEGVTDVLYPG------------------RGGMLSFRIQ 289
Query: 316 SGDNALAFLRGLKRIFPSPSLGGVESIATYPVKSAAKTLDEEIREILGITDGLIRLSVGL 375
S FL+ LK I + SLGGVES+ TYP + E++R G+ + L+R SVG+
Sbjct: 290 SESWVNPFLQSLKLISFAESLGGVESLMTYPATQTHADIPEDVRIANGVCNRLLRFSVGI 349
Query: 376 EPLDELIEDIDNALGVV 392
E + +LI D+D A V
Sbjct: 350 EHVGDLIADLDQAFNRV 366
>sp|P55218|METZ_PSEAE O-SUCCINYLHOMOSERINE SULFHYDRYLASE (OSH SULFHYDRYLASE)
>gi|11350687|pir||F83256 o-succinylhomoserine
sulfhydrylase PA3107 [imported] - Pseudomonas aeruginosa
(strain PAO1) >gi|607830|gb|AAA83435.1| (U10904)
O-succinylhomoserine sulfhydrylase [Pseudomonas
aeruginosa] >gi|9949218|gb|AAG06495.1|AE004735_2
(AE004735) o-succinylhomoserine sulfhydrylase
[Pseudomonas aeruginosa]
Length = 403
Score = 226 bits (571), Expect = 3e-58
Identities = 130/341 (38%), Positives = 197/341 (57%), Gaps = 9/341 (2%)
Query: 57 YSREENPTVRKLEDKLAELEGSDNALAFNSGMSAISTLYFSLLEGGDKVVLSMEGYGTTI 116
YSR NPTVR E+++A LEG++ A+A SGMSAI L SL GD V++S +G+TI
Sbjct: 67 YSRYTNPTVRTFEERIAALEGAEQAVATASGMSAILALVMSLCSSGDHVLVSRSVFGSTI 126
Query: 117 ELA-KLLRKFGVDVKLAYPSADSLIE---TIDEETKLVLVETMTNPTLKVIDVPEVAKRC 172
L K ++FG+ V YP L TKL VE+ +NP +++D+ +A+
Sbjct: 127 SLFDKYFKRFGIQVD--YPPLSDLAAWEAACKPNTKLFFVESPSNPLAELVDIAALAEIA 184
Query: 173 REVGAILVVDNTFVTPLLYKPLEDGASYVVHSLTKYIAGHNDVLGGAVLWNGEFSRDLWE 232
GA+L VDN F TP L +PL+ GA V+HS TKYI G +GG V GE +++
Sbjct: 185 HAKGALLAVDNCFCTPALQQPLKLGADVVIHSATKYIDGQGRGMGGVVAGRGEQMKEVVG 244
Query: 233 WRRRLGTIIQPFDAWMIERGMRTLEVRFERQSENAMAIAEFLKDHPKVREVHYPGLKDDP 292
+ R G + PF+AW+ +G+ TL +R + S +A+A+AE+L+ P + V+Y GL P
Sbjct: 245 FLRTAGPTLSPFNAWLFLKGLETLRIRMQAHSASALALAEWLERQPGIERVYYAGLPSHP 304
Query: 293 YYKVARRLFKKDLYGGVVAFDL-GSGDNALAFLRGLKRIFPSPSLGGVESIATYPVKSAA 351
+++ARR ++ +G VV+FD+ G D A F+ + + + +LG ++ +P ++
Sbjct: 305 QHELARR--QQSGFGAVVSFDVKGGRDAAWRFIDATRMVSITTNLGDTKTTIAHPATTSH 362
Query: 352 KTLDEEIREILGITDGLIRLSVGLEPLDELIEDIDNALGVV 392
L E R GI D LIR++VGLE LD+L D+ L +
Sbjct: 363 GRLSPEDRARAGIGDSLIRVAVGLEDLDDLKADMARGLAAL 403
>pir||T21246 hypothetical protein F22B8.6 - Caenorhabditis elegans
>gi|3876285|emb|CAB05492.1| (Z83106) predicted using
Genefinder~contains similarity to Pfam domain: PF01053
(Cys/Met metabolism PLP-dependent enzyme), Score=785.6,
E-value=6.4e-233, N=1 [Caenorhabditis elegans]
Length = 392
Score = 226 bits (569), Expect = 5e-58
Identities = 140/366 (38%), Positives = 209/366 (56%), Gaps = 14/366 (3%)
Query: 33 PLYITAVFKQVGDAYPTDRGTELKYSREENPTVRKLEDKLAELEGSDNALAFNSGMSAIS 92
P+ ++ +KQ P Y+R NPT L+ LA LEG+ + AF+SG++A S
Sbjct: 29 PISMSTTYKQDNPGEPK----RYDYARGGNPTRDVLQKNLAALEGAKHCQAFSSGLAASS 84
Query: 93 TLYFSLLEGGDKVVLSMEGYGTTIELAKLL--RKFGVDV-KLAYPSADSLIETIDEETKL 149
+ +LL GD +V S + YG TI + + +K+G++V + +L + I TK+
Sbjct: 85 AV-INLLNHGDHIVCSDDVYGGTIRYIRQIAVKKYGMEVDSVDLTDVQNLEKAIKPNTKM 143
Query: 150 VLVETMTNPTLKVIDVPEVAKRCREVGA--ILVVDNTFVTPLLYKPLEDGASYVVHSLTK 207
V E+ +NP LKV+D+ V + + ++VVDNTF+TP +PL GA VHS+TK
Sbjct: 144 VWFESPSNPLLKVVDIAAVVQTAKRANPEIVVVVDNTFMTPYFQRPLSLGADIAVHSITK 203
Query: 208 YIAGHNDVLGGAVLWNG-EFSRDLWEWRRRLGTIIQPFDAWMIERGMRTLEVRFERQSEN 266
YI GH+D++ GA + N EF + L +R +G + PFD +++ RG++TL VR + EN
Sbjct: 204 YINGHSDIIMGAAITNNDEFQQHLHFMQRAIGGVPSPFDCFLVNRGLKTLHVRMKAHFEN 263
Query: 267 AMAIAEFLKDHPKVREVHYPGLKDDPYYKVARRLFKKDLYGGVVAFDL-GSGDNALAFLR 325
A+AIA+FL+ H + V YP L P + V + K G+++F L G + AFL
Sbjct: 264 ALAIAKFLEAHDCIESVLYPALPSHPQHTVHVKQTKG--MSGMISFYLKGELCQSRAFLS 321
Query: 326 GLKRIFPSPSLGGVESIATYPVKSAAKTLDEEIREILGITDGLIRLSVGLEPLDELIEDI 385
LK + SLGG ES+A P ++ R LGITD LIR+SVG+E LD+LI D+
Sbjct: 322 ALKVFTLAESLGGCESLAELPSIMTHASVPSATRAELGITDNLIRISVGIEDLDDLIADL 381
Query: 386 DNALGV 391
D AL +
Sbjct: 382 DQALKI 387
>sp|P13254|MEGL_PSEPU METHIONINE GAMMA-LYASE (L-METHIONINASE) >gi|1084040|pir||JC4174
methionine gamma-lyase (EC 4.4.1.11) - Pseudomonas
putida >gi|902932|dbj|BAA13642.1| (D88554) L-methionine
gamma-lyase [Pseudomonas putida]
>gi|2217945|dbj|BAA20553.1| (D89015) L-methionine
gamma-lyase [Pseudomonas putida]
>gi|1096717|prf||2112270A Met gamma-lyase [Pseudomonas
putida]
Length = 398
Score = 225 bits (568), Expect = 6e-58
Identities = 138/366 (37%), Positives = 204/366 (55%), Gaps = 11/366 (3%)
Query: 33 PLYITAVFK----QVGDAYPTDRGTELKYSREENPTVRKLEDKLAELEGSDNALAFNSGM 88
P+Y TA F + G A YSR NPT+ LE ++A LEG + LA SGM
Sbjct: 31 PVYQTATFTFPTVEYGAACFAGEQAGHFYSRISNPTLNLLEARMASLEGGEAGLALASGM 90
Query: 89 SAISTLYFSLLEGGDKVVLSMEGYGTTIE-LAKLLRKFGVDVK-LAYPSADSLIETIDEE 146
AI++ ++LL GD+V+L YG T L + +FGV ++ + +L +
Sbjct: 91 GAITSTLWTLLRPGDEVLLGNTLYGCTFAFLHHGIGEFGVKLRHVDMADLQALEAAMTPA 150
Query: 147 TKLVLVETMTNPTLKVIDVPEVAKRCREVGAILVVDNTFVTPLLYKPLEDGASYVVHSLT 206
T+++ E+ NP + + D+ VAK R+ GA +VVDNT+ TP L +PLE GA VVHS T
Sbjct: 151 TRVIYFESPANPNMHMADIAGVAKIARKHGATVVVDNTYCTPYLQRPLELGADLVVHSAT 210
Query: 207 KYIAGHNDVLGGAVLWNGEF--SRDLWEWRRRLGTIIQPFDAWMIERGMRTLEVRFERQS 264
KY++GH D+ G V+ + L + G ++ P DA ++ RG++TL +R +R
Sbjct: 211 KYLSGHGDITAGIVVGSQALVDRIRLQGLKDMTGAVLSPHDAALLMRGIKTLNLRMDRHC 270
Query: 265 ENAMAIAEFLKDHPKVREVHYPGLKDDPYYKVARRLFKKDLYGGVVAFDLGSGDNA-LAF 323
NA +AEFL P+V +HYPGL P Y +AR+ + GG++AF+L G A F
Sbjct: 271 ANAQVLAEFLARQPQVELIHYPGLASFPQYTLARQQMSQP--GGMIAFELKGGIGAGRRF 328
Query: 324 LRGLKRIFPSPSLGGVESIATYPVKSAAKTLDEEIREILGITDGLIRLSVGLEPLDELIE 383
+ L+ + SLG ES+A +P + E R GI++GL+RLSVGLE +D+L+
Sbjct: 329 MNALQLFSRAVSLGDAESLAQHPASMTHSSYTPEERAHYGISEGLVRLSVGLEDIDDLLA 388
Query: 384 DIDNAL 389
D+ AL
Sbjct: 389 DVQQAL 394
>dbj|BAB05455.1| (AP001513) cystathionine gamma-lyase [Bacillus halodurans]
Length = 398
Score = 224 bits (566), Expect = 1e-57
Identities = 131/337 (38%), Positives = 198/337 (57%), Gaps = 7/337 (2%)
Query: 57 YSREENPTVRKLEDKLAELEGSDNALAFNSGMSAISTLYFSLLEGGDKVVLSMEGYGTTI 116
Y R NPTV+ E+K+ ELE ++ A +F +GM+AIS ++L+ GD+VV + YG T
Sbjct: 61 YGRNTNPTVQAFEEKVRELEFAEAATSFATGMAAISNSLLTVLKPGDRVVSIKDTYGGTN 120
Query: 117 EL-AKLLRKFGVDVKLAYPSADSLIET-IDEETKLVLVETMTNPTLKVIDVPEVAKRCRE 174
++ ++ L + ++V L +E I + LV +ET TNPT+K+ D+ + E
Sbjct: 121 KIFSEFLPRLKIEVTLCETGDHEALEREITKGCTLVYLETPTNPTVKITDLERITSFAHE 180
Query: 175 VGAILVVDNTFVTPLLYKPLEDGASYVVHSLTKYIAGHNDVLGGAVLWNGEFSRDLWEWR 234
A++ VDNTF TP+ PL GA VVHS TK++ GH D LGG N E ++ +R
Sbjct: 181 HNALVFVDNTFATPINQNPLLTGADLVVHSATKFLGGHADALGGVACGNKELVSAIYHYR 240
Query: 235 RRLGTIIQPFDAWMIERGMRTLEVRFERQSENAMAIAEFLKDHPKVREVHYPGLKDDPYY 294
G + P A+++ RGM+TL++R E+Q ENAM +A FL +H KVR V+YPGL+ P++
Sbjct: 241 EINGATLDPMAAYLLLRGMKTLKLRVEKQQENAMKVARFLTEHDKVRAVYYPGLETHPHH 300
Query: 295 KVARRLFKKDLYGGVVAFDL-GSGDNALAFLRGLKRIFPSPSLGGVE-SIATYPVKSAAK 352
+VA+R + +GG+++F L G + FL L + +LG VE ++ S +
Sbjct: 301 EVAKRQMRG--FGGMLSFALKGEMEAVRKFLPALTYANRAANLGAVETTVGPARTTSHVE 358
Query: 353 TLDEEIREILGITDGLIRLSVGLEPLDELIEDIDNAL 389
EE R LGI +GL+R S G+E +LIED+ AL
Sbjct: 359 NTPEE-RAALGIPEGLVRYSAGIEDAVDLIEDLSQAL 394
>sp|P44502|METB_HAEIN CYSTATHIONINE GAMMA-SYNTHASE (CGS) (O-SUCCINYLHOMOSERINE
(THIOL)-LYASE)
Length = 369
Score = 223 bits (562), Expect = 3e-57
Identities = 135/371 (36%), Positives = 200/371 (53%), Gaps = 32/371 (8%)
Query: 19 DQREGEIKMKPLHDPLYITAVFKQVGDAYPTDRGTELKYSREENPTVRKLEDKLAELEGS 78
D+R G + P++++ + G T Y+R +NPT LE+ +A+LE
Sbjct: 19 DERTGAVSA-----PIFLSTAYGHCG----IGESTGFDYTRTKNPTRTVLEETIAKLENG 69
Query: 79 DNALAFNSGMSAISTLYFSLLEGGDKVVLSMEGYGTTIELAKLLRKFGVDVKLAY---PS 135
D AF+SGM+AI L +L D+ ++S + YG T L K VK Y S
Sbjct: 70 DRGFAFSSGMAAIQVL-MTLFTAPDEWIVSSDVYGGTYRLLDFSYKNNNSVKPVYVNTAS 128
Query: 136 ADSLIETIDEETKLVLVETMTNPTLKVIDVPEVAKRCREVGAILVVDNTFVTPLLYKPLE 195
A ++ I+ TK + +ET +NP ++ DV E+AK ++ +L+VDNTF+TP+L +PL+
Sbjct: 129 ASAIEAAINPNTKAIFIETPSNPLMEECDVVEIAKLAKKHNLMLIVDNTFLTPVLSRPLD 188
Query: 196 DGASYVVHSLTKYIAGHNDVLGGAVLWNGEFSRDLWEW-RRRLGTIIQPFDAWMIERGMR 254
GA V+HS TKYIAGHND L G ++ G+ D + + G ++ PFD+W+ RGM+
Sbjct: 189 LGADVVIHSGTKYIAGHNDALVGLIVAKGQELCDRIAYIQNGAGAVLSPFDSWLTIRGMK 248
Query: 255 TLEVRFERQSENAMAIAEFLKDHPKVREVHYPGLKDDPYYKVARRLFKKDLYGGVVAFDL 314
TL +R +R ENA AIAEFLK P+V V YP GG+++F L
Sbjct: 249 TLSLRMKRHQENAQAIAEFLKAQPQVESVLYPN------------------KGGMLSFRL 290
Query: 315 GSGDNALAFLRGLKRIFPSPSLGGVESIATYPVKSAAKTLDEEIREILGITDGLIRLSVG 374
FL+ +K I + SLGG ES TYP + E R GIT+ L+R SVG
Sbjct: 291 QDEAWVNTFLKSIKLITFAESLGGTESFITYPATQTHMDIPESERVARGITNTLLRFSVG 350
Query: 375 LEPLDELIEDI 385
+E ++++ D+
Sbjct: 351 IEDVEDIKADL 361
>gb|AAF74980.1|AF082890_1 (AF082890) cystathionine beta-lyase [Solanum tuberosum]
Length = 471
Score = 223 bits (562), Expect = 3e-57
Identities = 132/363 (36%), Positives = 218/363 (59%), Gaps = 10/363 (2%)
Query: 30 LHDPLYITAVFKQVGDAYPTDRGTELKYSREENPTVRKLEDKLAELEGSDNALAFNSGMS 89
L PLY T+ FKQ T+ G + Y+R NPT LE LAELE +D A F SGM+
Sbjct: 111 LSTPLYQTSTFKQPS---ATENG-QYDYTRSGNPTRDALEKLLAELEKADRAFCFTSGMA 166
Query: 90 AISTLYFSLLEGGDKVVLSMEGYGTTIEL-AKLLRKFGVDVK-LAYPSADSLIETIDEET 147
A++ + L++ G+++V + YG + L ++++ K G+ VK + + D + I T
Sbjct: 167 ALAAVT-RLVKAGEEIVAGDDIYGGSDRLLSQVVPKAGIVVKRVDTTNLDEVASVIKPWT 225
Query: 148 KLVLVETMTNPTLKVIDVPEVAKRCREVGAILVVDNTFVTPLLYKPLEDGASYVVHSLTK 207
KL+ +E+ TNP ++ D+ ++AK GA+++VDN+ ++P+L PLE GA V+HS TK
Sbjct: 226 KLIWLESPTNPRQQICDIRKIAKIAHAHGALVLVDNSIMSPVLSHPLELGADIVMHSATK 285
Query: 208 YIAGHNDVLGGAVLWNGE-FSRDLWEWRRRLGTIIQPFDAWMIERGMRTLEVRFERQSEN 266
+I+GH+D++ G + GE +++++ + G + PFD W+ RG++T+ +R E+Q EN
Sbjct: 286 FISGHSDLMAGVLAVRGESLAKEVYFLQNAEGAGLAPFDCWLCLRGIKTMALRVEKQQEN 345
Query: 267 AMAIAEFLKDHPKVREVHYPGLKDDPYYKVARRLFKKDLYGGVVAFDLGSGDNALAFLRG 326
A IAEFL HP+V++V+YPGL D P + + G V++F GS +
Sbjct: 346 AQKIAEFLSSHPRVKKVNYPGLLDHPGRSL--HFSQATGAGSVLSFLTGSLALSKHVAEA 403
Query: 327 LKRIFPSPSLGGVESIATYPVKSAAKTLDEEIREILGITDGLIRLSVGLEPLDELIEDID 386
K + S G V+S+ + P + ++ E+RE G+T+ L+R+SVG+E +++LI+D+D
Sbjct: 404 TKYFSITVSFGSVKSLISLPCFMSHASIPVEVREARGLTEDLVRISVGIEDVNDLIDDLD 463
Query: 387 NAL 389
AL
Sbjct: 464 YAL 466
>pir||G64047 cystathionine gamma-lyase homolog - Haemophilus influenzae (strain
Rd KW20) >gi|1573037|gb|AAC21764.1| (U32694)
cystathionine gamma-synthase (metB) [Haemophilus
influenzae Rd]
Length = 381
Score = 223 bits (562), Expect = 3e-57
Identities = 135/371 (36%), Positives = 200/371 (53%), Gaps = 32/371 (8%)
Query: 19 DQREGEIKMKPLHDPLYITAVFKQVGDAYPTDRGTELKYSREENPTVRKLEDKLAELEGS 78
D+R G + P++++ + G T Y+R +NPT LE+ +A+LE
Sbjct: 31 DERTGAVSA-----PIFLSTAYGHCG----IGESTGFDYTRTKNPTRTVLEETIAKLENG 81
Query: 79 DNALAFNSGMSAISTLYFSLLEGGDKVVLSMEGYGTTIELAKLLRKFGVDVKLAY---PS 135
D AF+SGM+AI L +L D+ ++S + YG T L K VK Y S
Sbjct: 82 DRGFAFSSGMAAIQVL-MTLFTAPDEWIVSSDVYGGTYRLLDFSYKNNNSVKPVYVNTAS 140
Query: 136 ADSLIETIDEETKLVLVETMTNPTLKVIDVPEVAKRCREVGAILVVDNTFVTPLLYKPLE 195
A ++ I+ TK + +ET +NP ++ DV E+AK ++ +L+VDNTF+TP+L +PL+
Sbjct: 141 ASAIEAAINPNTKAIFIETPSNPLMEECDVVEIAKLAKKHNLMLIVDNTFLTPVLSRPLD 200
Query: 196 DGASYVVHSLTKYIAGHNDVLGGAVLWNGEFSRDLWEW-RRRLGTIIQPFDAWMIERGMR 254
GA V+HS TKYIAGHND L G ++ G+ D + + G ++ PFD+W+ RGM+
Sbjct: 201 LGADVVIHSGTKYIAGHNDALVGLIVAKGQELCDRIAYIQNGAGAVLSPFDSWLTIRGMK 260
Query: 255 TLEVRFERQSENAMAIAEFLKDHPKVREVHYPGLKDDPYYKVARRLFKKDLYGGVVAFDL 314
TL +R +R ENA AIAEFLK P+V V YP GG+++F L
Sbjct: 261 TLSLRMKRHQENAQAIAEFLKAQPQVESVLYPN------------------KGGMLSFRL 302
Query: 315 GSGDNALAFLRGLKRIFPSPSLGGVESIATYPVKSAAKTLDEEIREILGITDGLIRLSVG 374
FL+ +K I + SLGG ES TYP + E R GIT+ L+R SVG
Sbjct: 303 QDEAWVNTFLKSIKLITFAESLGGTESFITYPATQTHMDIPESERVARGITNTLLRFSVG 362
Query: 375 LEPLDELIEDI 385
+E ++++ D+
Sbjct: 363 IEDVEDIKADL 373
>pir||F83595 probable cystathionine gamma-lyase PA0400 [imported] - Pseudomonas
aeruginosa (strain PAO1)
>gi|9946254|gb|AAG03789.1|AE004477_6 (AE004477) probable
cystathionine gamma-lyase [Pseudomonas aeruginosa]
Length = 394
Score = 222 bits (561), Expect = 4e-57
Identities = 132/344 (38%), Positives = 199/344 (57%), Gaps = 9/344 (2%)
Query: 55 LKYSREENPTVRKLEDKLAELEGSDNALAFNSGMSAISTLYFSLLEGGDKVVLSMEGYGT 114
L Y R NPT LE +A+LEG A AF SG++AIS++ LL+ G +V + YG
Sbjct: 54 LDYGRSHNPTRWALERCVADLEGGTQAFAFASGLAAISSV-LELLDAGSHIVSGNDLYGG 112
Query: 115 TIELAKLLRKFGVDVKLAYPSADSLIE---TIDEETKLVLVETMTNPTLKVIDVPEVAKR 171
T L + +R+ + ++ L + ET++V VET +NP L++ D+ +A+
Sbjct: 113 TFRLFERVRRRSAGHRFSFVDPTDLQAFEAALTPETRMVWVETPSNPLLRLTDLRAIAQL 172
Query: 172 CREVGAILVVDNTFVTPLLYKPLEDGASYVVHSLTKYIAGHNDVLGGAVLW--NGEFSRD 229
CR G I V DNTF +P + +PLE G VVHS TKY+ GH+DV+GG + N +
Sbjct: 173 CRARGIISVADNTFASPYIQRPLELGFDVVVHSTTKYLNGHSDVIGGIAIVGDNPDLRER 232
Query: 230 LWEWRRRLGTIIQPFDAWMIERGMRTLEVRFERQSENAMAIAEFLKDHPKVREVHYPGLK 289
L + +G I PFDA++ RG++TL +R ER NA+A+A++L+ P+V V+YPGL
Sbjct: 233 LGFLQNSVGAISGPFDAFLTLRGVKTLALRMERHCSNALALAQWLERQPQVARVYYPGLA 292
Query: 290 DDPYYKVARRLFKKDLYGGVVAFDLGSG-DNALAFLRGLKRIFPSPSLGGVESIATYPVK 348
P +++A+R + +GG+++ DL A FL ++ + SLGGVES+ +P
Sbjct: 293 SHPQHELAKRQMRG--FGGMISLDLRCDLAGARRFLENVRIFSLAESLGGVESLIEHPAI 350
Query: 349 SAAKTLDEEIREILGITDGLIRLSVGLEPLDELIEDIDNALGVV 392
++ E R LGI D LIRLSVG+E L++L D+ AL +
Sbjct: 351 MTHASIPAETRADLGIGDSLIRLSVGVEALEDLQADLAQALAKI 394
>sp|O53427|METB_MYCTU CYSTATHIONINE GAMMA-SYNTHASE (CGS) (O-SUCCINYLHOMOSERINE
(THIOL)-LYASE) >gi|7437081|pir||E70894 probable metB
protein - Mycobacterium tuberculosis (strain H37RV)
>gi|2896716|emb|CAA17195.1| (AL021897) metB
[Mycobacterium tuberculosis]
Length = 388
Score = 222 bits (560), Expect = 5e-57
Identities = 143/364 (39%), Positives = 209/364 (57%), Gaps = 16/364 (4%)
Query: 33 PLYITAVFKQVGDAYPTDRGTELKYSREENPTVRKLEDKLAELEGSDNALAFNSGMSAIS 92
P+Y ++ F Q D RG +Y+R NPT LE LA +E A AF+SGM+A
Sbjct: 35 PIYASSTFAQ--DGVGGLRGG-FEYARTGNPTRAALEASLAAVEEGAFARAFSSGMAATD 91
Query: 93 TLYFSLLEGGDKVVLSMEGYGTTIELA-KLLRKFGVD---VKLAYPSADSLIETIDEETK 148
++L GD VV+ + YG T L K+ ++ V V+LA D++ I T+
Sbjct: 92 CALRAMLRPGDHVVIPDDAYGGTFRLIDKVFTRWDVQYTPVRLA--DLDAVGAAITPRTR 149
Query: 149 LVLVETMTNPTLKVIDVPEVAKRCREVGAILVVDNTFVTPLLYKPLEDGASYVVHSLTKY 208
L+ VET TNP L + D+ +A+ + A ++VDNTF +P L +PL GA V+HS TKY
Sbjct: 150 LIWVETPTNPLLSIADITAIAELGTDRSAKVLVDNTFASPALQQPLRLGADVVLHSTTKY 209
Query: 209 IAGHNDVLGGAVLWNG-EFSRDLWEWRRRLGTIIQPFDAWMIERGMRTLEVRFERQSENA 267
I GH+DV+GGA++ N E + + G + PFDA++ RG++TL +R +R SENA
Sbjct: 210 IGGHSDVVGGALVTNDEELDEEFAFLQNGAGAVPGPFDAYLTMRGLKTLVLRMQRHSENA 269
Query: 268 MAIAEFLKDHPKVREVHYPGLKDDPYYKVARRLFKKDLYGGVVAFDLGSGDNALAFLRGL 327
A+AEFL DHP V V YPGL P +++A R + +GG+V+ + +G A L
Sbjct: 270 CAVAEFLADHPSVSSVLYPGLPSHPGHEIAARQMRG--FGGMVSVRMRAGRRAAQDLCAK 327
Query: 328 KRIF-PSPSLGGVESIATYPVKSAAKTLDEEIREILGITDGLIRLSVGLEPLDELIEDID 386
R+F + SLGGVES+ +P +A T L + D L+RLSVG+E + +L+ D++
Sbjct: 328 TRVFILAESLGGVESLIEHP---SAMTHASTAGSQLEVPDDLVRLSVGIEDIADLLGDLE 384
Query: 387 NALG 390
ALG
Sbjct: 385 QALG 388
>pir||T43791 cystathionine beta-synthase [imported] - Clostridium perfringens
(fragment) >gi|5106357|dbj|BAA81639.1| (AB028629)
cystathionine beta-synthase [Clostridium perfringens]
Length = 351
Score = 222 bits (559), Expect = 7e-57
Identities = 126/336 (37%), Positives = 195/336 (57%), Gaps = 6/336 (1%)
Query: 56 KYSREENPTVRKLEDKLAELEGSDNALAFNSGMSAISTLYFSLLEGGDKVVLSMEGYGTT 115
+YSR NPT LE +A++E AF SG++AI T SL + GDK++++ YG T
Sbjct: 10 EYSRTGNPTRESLEKLIADIEYGKRGFAFASGLAAI-TAVLSLFKSGDKLLITNNLYGGT 68
Query: 116 IELA-KLLRKFGVDVKLAYPSADSLIETIDEETKLVLVETMTNPTLKVIDVPEVAKRCRE 174
+ K+ FG+ ++ ++ E ID+ K + +ET TNP L VID+ + + ++
Sbjct: 69 FRVIDKIFSNFGIGYEII-DDFTNIEEKIDKSVKAIYIETPTNPLLDVIDIKIASDKAKK 127
Query: 175 VGAILVVDNTFVTPLLYKPLEDGASYVVHSLTKYIAGHNDVLGG-AVLWNGEFSRDLWEW 233
+ +VDNTF+TP PL GA V+HS TKY+ GH+D++ G V+ + E +
Sbjct: 128 YNLLTIVDNTFMTPYFQNPLNLGADIVIHSATKYLGGHSDLVAGLVVVKDEELGEKIHFI 187
Query: 234 RRRLGTIIQPFDAWMIERGMRTLEVRFERQSENAMAIAEFLKDHPKVREVHYPGLKDDPY 293
+ G I+QPFD++++ RG++TL VR +R NA IAE L D + V+YPGLK
Sbjct: 188 QNSTGGILQPFDSFLLIRGIKTLSVRMDRHELNANFIAEKLGDLEGIDNVYYPGLKTHIG 247
Query: 294 YKVARRLFKKDLYGGVVAFDLGSGDNALAFLRGLKRIFPSPSLGGVESIATYPVKSAAKT 353
+ + ++ + +GG+++F L N F L+ I SLGGVES+A +P
Sbjct: 248 HDIQKK--QASGFGGIISFTLNKKYNYEKFFNSLELITFGESLGGVESLACHPASMTHAA 305
Query: 354 LDEEIREILGITDGLIRLSVGLEPLDELIEDIDNAL 389
+ E+RE +GITD LIR+SVG+E ++++EDI AL
Sbjct: 306 MPLELRERIGITDRLIRISVGIEDKEDILEDIQKAL 341
>gb|AAF57663.1| (AE003799) Eip55E gene product [Drosophila melanogaster]
Length = 393
Score = 221 bits (557), Expect = 1e-56
Identities = 139/365 (38%), Positives = 211/365 (57%), Gaps = 13/365 (3%)
Query: 33 PLYITAVFKQVGDAYPTDRGTELKYSREENPTVRKLEDKLAELEGSDNALAFNSGMSAIS 92
P+ ++ FKQ DA RG E YSR NPT LE A L+ + L F+SG+ A +
Sbjct: 32 PISLSTTFKQ--DAPGEHRGYE--YSRSGNPTRNVLETCFAALDNAKYGLTFSSGLGA-T 86
Query: 93 TLYFSLLEGGDKVVLSMEGYGTTIELAK-LLRKFGVDVKLAYPSADSLIET-IDEETKLV 150
T ++L GD +++ + YG T L + + + G+ P+ LI++ I ETKLV
Sbjct: 87 TAVLTMLSSGDHIIMGDDVYGGTNRLIRQVATRLGISATFVDPTKLDLIKSSIKPETKLV 146
Query: 151 LVETMTNPTLKVIDVPEVAKRCREV--GAILVVDNTFVTPLLYKPLEDGASYVVHSLTKY 208
+E+ TNP +KV D+ +A+ V +L VDNTF+T +PLE GA V +SLTKY
Sbjct: 147 WIESPTNPLVKVADIEAIAQLVHGVREDIVLAVDNTFLTSYFQRPLELGADLVCYSLTKY 206
Query: 209 IAGHNDVLGGAVLWNGE-FSRDLWEWRRRLGTIIQPFDAWMIERGMRTLEVRFERQSENA 267
+ GH DV+ G + N E + L + +G + PFD + + R ++TL +R E+ +NA
Sbjct: 207 MNGHTDVVMGGITMNSEKLYKSLKFLQNAVGIVPSPFDCYQVNRSLKTLSLRMEQHQKNA 266
Query: 268 MAIAEFLKDHPKVREVHYPGLKDDPYYKVARRLFKKDLYGGVVAFDL-GSGDNALAFLRG 326
+ +A++L+ +P V +V +P L P +K+A L + Y GV +F + G ++ AFL+
Sbjct: 267 LKVAKYLETNPFVEKVLHPSLPSHPQHKIA--LKQAYGYSGVFSFYIKGELKHSSAFLKA 324
Query: 327 LKRIFPSPSLGGVESIATYPVKSAAKTLDEEIREILGITDGLIRLSVGLEPLDELIEDID 386
LK + SLGG ES+A P ++ E R+ LGITDGL+RLSVGLE D+LI+D++
Sbjct: 325 LKVFTLAESLGGYESLAELPSIMTHASVPAEDRKTLGITDGLVRLSVGLEDADDLIKDLE 384
Query: 387 NALGV 391
AL +
Sbjct: 385 QALEI 389
>sp|P55216|CGL_CAEEL PUTATIVE CYSTATHIONINE GAMMA-LYASE (GAMMA-CYSTATHIONASE)
>gi|1330380|gb|AAB93432.1| (U58758) Contains similarity
to Pfam domain: PF01053 (Cys_Met_Meta_PP), Score=835.3,
E-value=6.8e-248, N=1 [Caenorhabditis elegans]
Length = 392
Score = 220 bits (554), Expect = 3e-56
Identities = 134/372 (36%), Positives = 213/372 (57%), Gaps = 14/372 (3%)
Query: 27 MKPLHDPLYITAVFKQVGDAYPTDRGTELKYSREENPTVRKLEDKLAELEGSDNALAFNS 86
M + P+ +++ +KQ P YSR NPT L+ LA LE + + F+S
Sbjct: 23 MNQVVPPISLSSTYKQDNPGEPKGHD----YSRAGNPTRDVLQKNLAALEDAKHCQVFSS 78
Query: 87 GMSAISTLYFSLLEGGDKVVLSMEGYGTTIELAKLLR--KFGVDV-KLAYPSADSLIETI 143
G++A S + +LL+ GD +V S + YG T + + G++V + +L + I
Sbjct: 79 GLAATSAI-INLLKYGDHIVCSDDVYGGTQRYIRRVAVPNHGLEVDSVDLTDVQNLEKAI 137
Query: 144 DEETKLVLVETMTNPTLKVIDVPEVAKRCREVGA--ILVVDNTFVTPLLYKPLEDGASYV 201
TK+V E+ +NP LKV+D+ V + ++ ++VVDNTF++P +P+ GA V
Sbjct: 138 KPNTKMVWFESPSNPLLKVVDIAAVVQTAKKANPEIVVVVDNTFMSPYFQRPISLGADVV 197
Query: 202 VHSLTKYIAGHNDVLGGAVLW-NGEFSRDLWEWRRRLGTIIQPFDAWMIERGMRTLEVRF 260
VHS+TKYI GH+DV+ GAV+ N EF + L+ + +G + PFD +++ RG++TL +R
Sbjct: 198 VHSITKYINGHSDVVMGAVITDNDEFQQHLFFMQLAVGAVPSPFDCFLVNRGLKTLHIRM 257
Query: 261 ERQSENAMAIAEFLKDHPKVREVHYPGLKDDPYYKVARRLFKKDLYGGVVAFDL-GSGDN 319
ENA+A+A++L+ + ++ V YP L P ++V + K G+++F L G
Sbjct: 258 RAHYENALAVAKYLEANDRIESVLYPALPSHPQHEVHEKQTKG--MSGMISFYLKGELQE 315
Query: 320 ALAFLRGLKRIFPSPSLGGVESIATYPVKSAAKTLDEEIREILGITDGLIRLSVGLEPLD 379
+ AFL LK + SLGG ES+A P ++ E R +LGITD LIR+SVG+E LD
Sbjct: 316 SRAFLSALKVFTLAESLGGYESLAELPSIMTHASVPAETRIVLGITDNLIRISVGIEDLD 375
Query: 380 ELIEDIDNALGV 391
+L+ D+D AL +
Sbjct: 376 DLVADLDQALKI 387
>pir||T45483 cystathionine gamma-lyase homolog [imported] - Stenotrophomonas
maltophilia >gi|2641242|gb|AAB86866.1| (AF031709)
cystathionine gamma-lyase-like protein [Stenotrophomonas
maltophilia]
Length = 391
Score = 220 bits (554), Expect = 3e-56
Identities = 135/364 (37%), Positives = 206/364 (56%), Gaps = 13/364 (3%)
Query: 33 PLYITAVFKQVGDAYPTDRGTELKYSREENPTVRKLEDKLAELEGSDNALAFNSGMSAIS 92
P+Y T+ + Q +G E YSR NPT E +A LEG AF SGM+A S
Sbjct: 34 PIYATSTYAQSSPG--EHQGFE--YSRTHNPTRFAYERCVASLEGGTRGFAFASGMAASS 89
Query: 93 TLYFSLLEGGDKVVLSMEGYGTTIELAKLLRKFGVDVKLAYPSADSLIE---TIDEETKL 149
T+ LL+ G VV + YG + L + +R+ + ++ L I +TK+
Sbjct: 90 TV-IELLDAGSHVVAMDDIYGGSFRLFERVRRRTAGLDFSFVDLTDLAAFEAAITSKTKM 148
Query: 150 VLVETMTNPTLKVIDVPEVAKRCREVGAILVVDNTFVTPLLYKPLEDGASYVVHSLTKYI 209
V +ET TNP LK++D+ V + G I+VVD+TF +P+L +PLE GA V+HS TKY+
Sbjct: 149 VWIETPTNPMLKIVDIAAVTAIAKRHGLIVVVDSTFASPMLQRPLELGADLVLHSATKYL 208
Query: 210 AGHNDVLGGAVLW--NGEFSRDLWEWRRRLGTIIQPFDAWMIERGMRTLEVRFERQSENA 267
GH+D++GG V+ N E + + + +G + PFD+++ RG++TL +R + NA
Sbjct: 209 NGHSDMVGGMVVVGDNAELAEQMAFLQNSVGGVQGPFDSFLALRGLKTLPLRMKAHCANA 268
Query: 268 MAIAEFLKDHPKVREVHYPGLKDDPYYKVARRLFKKDLYGGVVAFDLGSG-DNALAFLRG 326
+A+A++L+ HP V +V YPGL P +++A + YGG+V+ L G + A F
Sbjct: 269 LALAQWLEKHPAVEKVIYPGLASHPQHELAGKQMAG--YGGIVSIVLKGGFEAAKRFCEK 326
Query: 327 LKRIFPSPSLGGVESIATYPVKSAAKTLDEEIREILGITDGLIRLSVGLEPLDELIEDID 386
+ + SLGGVES+ +P ++ RE LGI+D L+RLSVG+E L +L D++
Sbjct: 327 TELFTLAESLGGVESLVNHPAVMTHASISVARREQLGISDALVRLSVGVEELGDLQVDLE 386
Query: 387 NALG 390
ALG
Sbjct: 387 RALG 390
>gb|AAB03240.1| (L43133) L-methionine-alpha-deamino-gamma-mercaptomethane- lyase
[Pseudomonas putida]
Length = 398
Score = 218 bits (550), Expect = 8e-56
Identities = 129/343 (37%), Positives = 199/343 (57%), Gaps = 17/343 (4%)
Query: 57 YSREENPTVRKLEDKLAELEGSDNALAFNSGMSAISTLYFSLLEGGDKVVLSMEGYGTTI 116
YSR NPT+ LE ++A LEG + LA SGM AI++ ++LL GD++++ YG T
Sbjct: 59 YSRISNPTLALLEQRMASLEGGEAGLALASGMGAITSTLWTLLRPGDELIVGRTLYGCTF 118
Query: 117 E-LAKLLRKFGVDVK-LAYPSADSLIETIDEETKLVLVETMTNPTLKVIDVPEVAKRCRE 174
L + +FGV + + A +L I+ +T+++ ET NP ++++D+ V + R
Sbjct: 119 AFLHHGIGEFGVKIHHVDLNDAKALKAAINSKTRMIYFETPANPNMQLVDIAAVVEAVRG 178
Query: 175 VGAILVVDNTFVTPLLYKPLEDGASYVVHSLTKYIAGHNDVLGGAVLWNGEFSRDLWEWR 234
++VVDNT+ TP L +PLE GA VVHS TKY++GH D+ G V+ R R
Sbjct: 179 SDVLVVVDNTYCTPYLQRPLELGADLVVHSATKYLSGHGDITAGLVV-----GRKALVDR 233
Query: 235 RRL-------GTIIQPFDAWMIERGMRTLEVRFERQSENAMAIAEFLKDHPKVREVHYPG 287
RL G + P DA ++ RG++TL +R +R NA+ +A+FL P+V +HYPG
Sbjct: 234 IRLEGLKDMTGAALSPHDAALLMRGIKTLALRMDRHCANALEVAQFLAGQPQVELIHYPG 293
Query: 288 LKDDPYYKVARRLFKKDLYGGVVAFDLGSGDNA-LAFLRGLKRIFPSPSLGGVESIATYP 346
L Y++A+R + L GG++AF+L G A F+ L+ + SLG ES+A +P
Sbjct: 294 LPSFAQYELAQRQMR--LPGGMIAFELKGGIEAGRGFMNALQLFARAVSLGDAESLAQHP 351
Query: 347 VKSAAKTLDEEIREILGITDGLIRLSVGLEPLDELIEDIDNAL 389
+ + R GI++GL+RLSVGLE +++L+ DI+ AL
Sbjct: 352 ASMTHSSYTPQERAHHGISEGLVRLSVGLEDVEDLLADIELAL 394
>gb|AAD17839.1| (AF095822) ecdysteroid-inducible polypeptide EIP40 [Drosophila
melanogaster]
Length = 393
Score = 218 bits (550), Expect = 8e-56
Identities = 138/365 (37%), Positives = 210/365 (56%), Gaps = 13/365 (3%)
Query: 33 PLYITAVFKQVGDAYPTDRGTELKYSREENPTVRKLEDKLAELEGSDNALAFNSGMSAIS 92
P+ ++ FKQ DA RG E YSR NPT LE A L+ + L F+SG+ A +
Sbjct: 32 PISLSTTFKQ--DAPGEHRGYE--YSRSGNPTRNVLETCFAALDNAKYGLTFSSGLGA-T 86
Query: 93 TLYFSLLEGGDKVVLSMEGYGTTIELAK-LLRKFGVDVKLAYPSADSLIET-IDEETKLV 150
T ++L GD +++ + YG T L + + + G+ P+ LI++ I ETKLV
Sbjct: 87 TAVLTMLSSGDHIIMGDDVYGGTNRLIRQVATRLGISATFVDPTKLDLIKSSIKPETKLV 146
Query: 151 LVETMTNPTLKVIDVPEVAKRCREV--GAILVVDNTFVTPLLYKPLEDGASYVVHSLTKY 208
+E+ TNP +KV D+ +A+ V +L VDNTF+T +PLE GA V +SLTKY
Sbjct: 147 WIESPTNPLVKVADIEAIAQLVHGVREDIVLAVDNTFLTSYFQRPLELGADLVCYSLTKY 206
Query: 209 IAGHNDVLGGAVLWNGE-FSRDLWEWRRRLGTIIQPFDAWMIERGMRTLEVRFERQSENA 267
+ GH DV+ G + N E + L + + + PFD + + R ++TL +R E+ +NA
Sbjct: 207 MNGHTDVVMGGITMNSEKLYKSLKFLQNAVDIVPSPFDCYQVNRSLKTLSLRMEQHQKNA 266
Query: 268 MAIAEFLKDHPKVREVHYPGLKDDPYYKVARRLFKKDLYGGVVAFDL-GSGDNALAFLRG 326
+ +A++L+ +P V +V +P L P +K+A L + Y GV +F + G ++ AFL+
Sbjct: 267 LKVAKYLETNPFVEKVLHPSLPSHPQHKIA--LKQAYGYSGVFSFYIKGELKHSSAFLKA 324
Query: 327 LKRIFPSPSLGGVESIATYPVKSAAKTLDEEIREILGITDGLIRLSVGLEPLDELIEDID 386
LK + SLGG ES+A P ++ E R+ LGITDGL+RLSVGLE D+LI+D++
Sbjct: 325 LKVFTLAESLGGYESLAELPSIMTHASVPAEDRKTLGITDGLVRLSVGLEDADDLIKDLE 384
Query: 387 NALGV 391
AL +
Sbjct: 385 QALEI 389
>gb|AAF74982.1|AF082892_1 (AF082892) cystathionine gamma-synthase isoform 2 [Solanum
tuberosum]
Length = 540
Score = 217 bits (548), Expect = 1e-55
Identities = 136/357 (38%), Positives = 196/357 (54%), Gaps = 10/357 (2%)
Query: 40 FKQVGDA--YPTDRGTELKYSREENPTVRKLEDKLAELEGSDNALAFNSGMSAISTLYFS 97
FK+ D + + +Y R NPT E+K++ LEG+D L SGM A + L +
Sbjct: 184 FKKTSDLIDFKEKKRASFEYGRYGNPTSIVAEEKISALEGADATLLMASGMCASTVLLLA 243
Query: 98 LLEGGDKVVLSMEGYGTT-IELAKLLRKFGVDVKLAYPSADSLIETIDEETKLVL--VET 154
L+ G +V + + Y T I + +L K G+ + P+ +E++ + K+ L E+
Sbjct: 244 LVPAGGHIVTTTDCYRKTRIFIETILPKMGITATVIDPADIGALESVLNQKKVTLFFTES 303
Query: 155 MTNPTLKVIDVPEVAKRCREVGAILVVDNTFVTPLLYKPLEDGASYVVHSLTKYIAGHND 214
TNP L+ +D+ V+K C E GA++ +D TF TPL K L GA VVHS TKY+ GHND
Sbjct: 304 PTNPFLRCVDIELVSKLCHEKGALVCIDGTFATPLNQKVLALGADLVVHSATKYLGGHND 363
Query: 215 VLGGAVLWNGEFSRDLWEWRRRLGTIIQPFDAWMIERGMRTLEVRFERQSENAMAIAEFL 274
VLGG + + + LG I P A++I RGM+TL +R ++Q+ A IAE L
Sbjct: 364 VLGGCISGPDKLVSAVRTLHHILGGAINPNAAYLIIRGMKTLHLRVQQQNSTAQRIAEIL 423
Query: 275 KDHPKVREVHYPGLKDDPYYKVARRLFKKDLYGGVVAFDLGSGD--NALAFLRGLKRIFP 332
+ HPKVR V+YPGL P Y +A+R + +GGVV+F++ GD F+ LK +
Sbjct: 424 EAHPKVRCVYYPGLPSHPEYHLAKR--QMTGFGGVVSFEV-DGDLLTTAKFVDALKIPYI 480
Query: 333 SPSLGGVESIATYPVKSAAKTLDEEIREILGITDGLIRLSVGLEPLDELIEDIDNAL 389
+PS GG ESI P + L E R GI D L+R S G+E ++L DI AL
Sbjct: 481 APSFGGCESIVDQPAIMSYWDLKESERAKYGIMDNLVRFSFGVEDFEDLKADILQAL 537
>emb|CAA64383.1| (X94756) cystathionine gamma-synthase [Arabidopsis thaliana]
Length = 563
Score = 217 bits (546), Expect = 2e-55
Identities = 128/346 (36%), Positives = 195/346 (55%), Gaps = 6/346 (1%)
Query: 51 RGTELKYSREENPTVRKLEDKLAELEGSDNALAFNSGMSAISTLYFSLLEGGDKVVLSME 110
R +Y R NPT LEDK++ LEG+++ L SGM A + + +L+ G +V + +
Sbjct: 220 RSVSFEYGRYGNPTTVVLEDKISALEGAESTLVMASGMCASTVMLLALVPAGGHIVTTTD 279
Query: 111 GYGTT-IELAKLLRKFGVDVKLAYPSADSLIETIDEETKLVL--VETMTNPTLKVIDVPE 167
Y T I + L K G+ V + P+ + +E E K+ L E+ TNP L+ +D+
Sbjct: 280 CYRKTRIFMENFLPKLGITVTVIDPADIAGLEAAVNEFKVSLFFTESPTNPFLRCVDIEL 339
Query: 168 VAKRCREVGAILVVDNTFVTPLLYKPLEDGASYVVHSLTKYIAGHNDVLGGAVLWNGEFS 227
V+K C + G ++ +D TF TPL K L GA VVHS TKYI GHNDVL G + + +
Sbjct: 340 VSKICHKRGTLVCIDGTFATPLNQKALALGADLVVHSATKYIGGHNDVLAGCICGSLKLV 399
Query: 228 RDLWEWRRRLGTIIQPFDAWMIERGMRTLEVRFERQSENAMAIAEFLKDHPKVREVHYPG 287
++ LG + P A++I RGM+TL +R ++Q+ A +AE L+ HPKV V+YPG
Sbjct: 400 SEIRNLHHVLGGTLNPNAAYLIIRGMKTLHLRVQQQNSTAFRMAEILEAHPKVSHVYYPG 459
Query: 288 LKDDPYYKVARRLFKKDLYGGVVAFDL-GSGDNALAFLRGLKRIFPSPSLGGVESIATYP 346
L P +++A+R + +GGVV+F++ G + + F+ LK + +PS GG ESI P
Sbjct: 460 LPSHPEHELAKR--QMTGFGGVVSFEIDGDIETTIKFVDSLKIPYIAPSFGGCESIVDQP 517
Query: 347 VKSAAKTLDEEIREILGITDGLIRLSVGLEPLDELIEDIDNALGVV 392
+ L +E R GI D L+R S G+E +++ DI AL +
Sbjct: 518 AIMSYWDLPQEERLKYGIKDNLVRFSFGVEDFEDVKADILQALEAI 563
>gb|AAB41235.1| (U83500) cystathionine gamma-synthase [Arabidopsis thaliana]
>gi|2852454|dbj|BAA24699.1| (AB010888) cystathionine
gamma-synthase [Arabidopsis thaliana]
>gi|6714476|gb|AAF26162.1|AC008261_19 (AC008261)
putative cystathionine gamma-synthase [Arabidopsis
thaliana]
Length = 563
Score = 217 bits (546), Expect = 2e-55
Identities = 128/346 (36%), Positives = 195/346 (55%), Gaps = 6/346 (1%)
Query: 51 RGTELKYSREENPTVRKLEDKLAELEGSDNALAFNSGMSAISTLYFSLLEGGDKVVLSME 110
R +Y R NPT LEDK++ LEG+++ L SGM A + + +L+ G +V + +
Sbjct: 220 RSVSFEYGRYGNPTTVVLEDKISALEGAESTLVMASGMCASTVMLLALVPAGGHIVTTTD 279
Query: 111 GYGTT-IELAKLLRKFGVDVKLAYPSADSLIETIDEETKLVL--VETMTNPTLKVIDVPE 167
Y T I + L K G+ V + P+ + +E E K+ L E+ TNP L+ +D+
Sbjct: 280 CYRKTRIFMENFLPKLGITVTVIDPADIAGLEAAVNEFKVSLFFTESPTNPFLRCVDIEL 339
Query: 168 VAKRCREVGAILVVDNTFVTPLLYKPLEDGASYVVHSLTKYIAGHNDVLGGAVLWNGEFS 227
V+K C + G ++ +D TF TPL K L GA VVHS TKYI GHNDVL G + + +
Sbjct: 340 VSKICHKRGTLVCIDGTFATPLNQKALALGADLVVHSATKYIGGHNDVLAGCICGSLKLV 399
Query: 228 RDLWEWRRRLGTIIQPFDAWMIERGMRTLEVRFERQSENAMAIAEFLKDHPKVREVHYPG 287
++ LG + P A++I RGM+TL +R ++Q+ A +AE L+ HPKV V+YPG
Sbjct: 400 SEIRNLHHVLGGTLNPNAAYLIIRGMKTLHLRVQQQNSTAFRMAEILEAHPKVSHVYYPG 459
Query: 288 LKDDPYYKVARRLFKKDLYGGVVAFDL-GSGDNALAFLRGLKRIFPSPSLGGVESIATYP 346
L P +++A+R + +GGVV+F++ G + + F+ LK + +PS GG ESI P
Sbjct: 460 LPSHPEHELAKR--QMTGFGGVVSFEIDGDIETTIKFVDSLKIPYIAPSFGGCESIVDQP 517
Query: 347 VKSAAKTLDEEIREILGITDGLIRLSVGLEPLDELIEDIDNALGVV 392
+ L +E R GI D L+R S G+E +++ DI AL +
Sbjct: 518 AIMSYWDLPQEERLKYGIKDNLVRFSFGVEDFEDVKADILQALEAI 563
>pir||T12288 O-succinylhomoserine (thiol)-lyase (EC 4.2.99.9) - common ice plant
>gi|3202028|gb|AAC19395.1| (AF069317) cystathionine
gamma-synthase [Mesembryanthemum crystallinum]
Length = 548
Score = 217 bits (546), Expect = 2e-55
Identities = 131/360 (36%), Positives = 200/360 (55%), Gaps = 10/360 (2%)
Query: 40 FKQVGDA--YPTDRGTELKYSREENPTVRKLEDKLAELEGSDNALAFNSGMSAISTLYFS 97
FK+ D + R T +Y R NPT LEDK++ LEG+++ + SGM A L +
Sbjct: 192 FKKTADLIDFKEGRQTSFEYGRYGNPTSVVLEDKISALEGAESTILLASGMCASIVLMLA 251
Query: 98 LLEGGDKVVLSMEGYGTT-IELAKLLRKFGVDVKLAYPS-ADSLIETIDEET-KLVLVET 154
L+ G +V + + Y T I + L K G+ + P+ + L +DE L E+
Sbjct: 252 LVPAGGHIVTTTDCYRKTRIFIETFLPKMGITATVIDPADVEGLKSALDENNVTLFFTES 311
Query: 155 MTNPTLKVIDVPEVAKRCREVGAILVVDNTFVTPLLYKPLEDGASYVVHSLTKYIAGHND 214
TNP L+ +D+ V++ C + GA++ +D TF TPL K L GA +VVHS+TK+I GHND
Sbjct: 312 PTNPFLRCVDIKLVSELCHKKGALVCIDGTFATPLNQKALALGADFVVHSMTKFIGGHND 371
Query: 215 VLGGAVLWNGEFSRDLWEWRRRLGTIIQPFDAWMIERGMRTLEVRFERQSENAMAIAEFL 274
VLGG + + + + LG + P A+++ RGM+TL +R ++Q+ A+ +AE L
Sbjct: 372 VLGGCISGSKNLISTIRTFHHVLGGTLNPNAAYLMIRGMKTLHLRVQQQNTTALRMAEIL 431
Query: 275 KDHPKVREVHYPGLKDDPYYKVARRLFKKDLYGGVVAFDLGSGD--NALAFLRGLKRIFP 332
+ HPKV+ V+YPGL P +K+A+R + +GGVV+F++ GD F+ LK +
Sbjct: 432 EAHPKVKHVYYPGLPSHPEHKLAKR--QMTGFGGVVSFEV-DGDLLTTAKFVDSLKIAYI 488
Query: 333 SPSLGGVESIATYPVKSAAKTLDEEIREILGITDGLIRLSVGLEPLDELIEDIDNALGVV 392
+PS GG ESI P + L R GI D L+R S G+E ++L D+ AL +
Sbjct: 489 APSFGGCESIVDQPAIMSYWDLSPSDRLKYGIKDNLVRFSFGVEDFEDLKADVLQALEAI 548
>emb|CAA04772.2| (AJ001451) cystathionine gamma synthase [Fragaria vesca]
>gi|6012969|emb|CAB57356.1| (Y17185) cystathionine gamma
synthase [Fragaria vesca]
Length = 545
Score = 217 bits (546), Expect = 2e-55
Identities = 129/356 (36%), Positives = 199/356 (55%), Gaps = 8/356 (2%)
Query: 40 FKQVGDA--YPTDRGTELKYSREENPTVRKLEDKLAELEGSDNALAFNSGMSAISTLYFS 97
FK+ D + R T +Y R NPT LE+K++ LEG+++ L SGM A + L +
Sbjct: 189 FKKTADLLDFKEKRATSFEYGRYGNPTTVVLEEKISALEGAESTLLLASGMCASTVLLMA 248
Query: 98 LLEGGDKVVLSMEGYGTT-IELAKLLRKFGVDVKLAYPSADSLIETIDEETKLVL--VET 154
L+ G +V + + Y T I + +L K G+ + P+ +ET E K+ L E+
Sbjct: 249 LVPAGGHIVTTTDCYRKTRIFIETILPKMGITATIIDPADVGALETALNENKVSLFFTES 308
Query: 155 MTNPTLKVIDVPEVAKRCREVGAILVVDNTFVTPLLYKPLEDGASYVVHSLTKYIAGHND 214
TNP L+ +D+ V+ C GA++ ++ TF TP+ K L GA VVHS TKY+AGHND
Sbjct: 309 PTNPFLRCVDINLVSDLCHSKGAVVCINGTFATPINQKALALGADLVVHSATKYLAGHND 368
Query: 215 VLGGAVLWNGEFSRDLWEWRRRLGTIIQPFDAWMIERGMRTLEVRFERQSENAMAIAEFL 274
VL G + + + ++ LG + P A++I RGM+TL +R ++Q+ A+ +A+ L
Sbjct: 369 VLAGCISGSMKLVSEIRILHHILGGALNPNAAYLIIRGMKTLHIRIQQQNSTALRMAKIL 428
Query: 275 KDHPKVREVHYPGLKDDPYYKVARRLFKKDLYGGVVAFDL-GSGDNALAFLRGLKRIFPS 333
+ HPKV V+YPGL P +++A+R + +GGVV+F++ G + F+ LK + +
Sbjct: 429 EAHPKVAHVYYPGLPSHPEHELAKR--QMTGFGGVVSFEIDGDLKRTIKFIDALKIPYIA 486
Query: 334 PSLGGVESIATYPVKSAAKTLDEEIREILGITDGLIRLSVGLEPLDELIEDIDNAL 389
PS GG ESI P + L + R GI D L+R S G+E ++L DI AL
Sbjct: 487 PSFGGCESIVDQPAIMSYWDLSQSDRLKYGIKDNLVRFSFGIEDFNDLKADILQAL 542
>gi|4503125 cystathionase (cystathionine gamma-lyase); Cystathionase [Homo
sapiens] >gi|1705788|sp|P32929|CGL_HUMAN CYSTATHIONINE
GAMMA-LYASE (GAMMA-CYSTATHIONASE)
>gi|262476|gb|AAB24700.1| (S52784) cystathionine
gamma-lyase, cystathionase {possibly alternatively
spliced} {EC 4.4.1.1} [human, liver, Peptide, 405 aa]
[Homo sapiens]
Length = 405
Score = 216 bits (545), Expect = 3e-55
Identities = 139/361 (38%), Positives = 208/361 (57%), Gaps = 10/361 (2%)
Query: 33 PLYITAVFKQVGDAYPTDRGTELKYSREENPTVRKLEDKLAELEGSDNALAFNSGMSAIS 92
P+ ++ FKQ + + +YSR NPT LE +A L+G+ LAF SG++A
Sbjct: 40 PISLSTTFKQGAPG----QHSGFEYSRSGNPTRNCLEKAVAALDGAKYCLAFASGLAATV 95
Query: 93 TLYFSLLEGGDKVVLSMEGYGTTIE-LAKLLRKFGVDVKLAYPSADSLIET-IDEETKLV 150
T+ LL+ GD+++ + YG T ++ +FG+ + S L+E I ETKLV
Sbjct: 96 TITH-LLKAGDQIICMDDVYGGTNRYFRQVASEFGLKISFVDCSKIKLLEAAITPETKLV 154
Query: 151 LVETMTNPTLKVIDVPEVAKRCREVG-AILVVDNTFVTPLLYKPLEDGASYVVHSLTKYI 209
+ET TNPT KVID+ A + G ILVVDNTF++P +PL GA ++S TKY+
Sbjct: 155 WIETPTNPTQKVIDIEGCAHIVHKHGDIILVVDNTFMSPYFQRPLALGADISMYSATKYM 214
Query: 210 AGHNDVLGGAVLWNGEFSRDLWEW-RRRLGTIIQPFDAWMIERGMRTLEVRFERQSENAM 268
GH+DV+ G V N E + + + LG + P D ++ RG++TL VR E+ +N M
Sbjct: 215 NGHSDVVMGLVSVNCESLHNRLRFLQNSLGAVPSPIDCYLCNRGLKTLHVRMEKHFKNGM 274
Query: 269 AIAEFLKDHPKVREVHYPGLKDDPYYKVARRLFKKDLYGGVVAFDLGSGDNALAFLRGLK 328
A+A+FL+ +P V +V YPGL P +++ +R G V + G+ +A FL+ LK
Sbjct: 275 AVAQFLESNPWVEKVIYPGLPSHPQHELVKRQCT-GCTGMVTFYIKGTLQHAEIFLKNLK 333
Query: 329 RIFPSPSLGGVESIATYPVKSAAKTLDEEIREILGITDGLIRLSVGLEPLDELIEDIDNA 388
+ SLGG ES+A P ++ + R++LGI+D LIRLSVGLE ++L+ED+D A
Sbjct: 334 LFTLAESLGGFESLAELPAIMTHASVLKNDRDVLGISDTLIRLSVGLEDEEDLLEDLDQA 393
Query: 389 L 389
L
Sbjct: 394 L 394
>gi|11424797 similar to cystathionase (cystathionine gamma-lyase) (H. sapiens)
[Homo sapiens]
Length = 405
Score = 216 bits (545), Expect = 3e-55
Identities = 139/361 (38%), Positives = 208/361 (57%), Gaps = 10/361 (2%)
Query: 33 PLYITAVFKQVGDAYPTDRGTELKYSREENPTVRKLEDKLAELEGSDNALAFNSGMSAIS 92
P+ ++ FKQ + + +YSR NPT LE +A L+G+ LAF SG++A
Sbjct: 40 PISLSTTFKQGAPG----QHSGFEYSRSGNPTRNCLEKAVAALDGAKYCLAFASGLAATV 95
Query: 93 TLYFSLLEGGDKVVLSMEGYGTTIE-LAKLLRKFGVDVKLAYPSADSLIET-IDEETKLV 150
T+ LL+ GD+++ + YG T ++ +FG+ + S L+E I ETKLV
Sbjct: 96 TITH-LLKAGDQIICMDDVYGGTNRYFRQVASEFGLKISFVDCSKIKLLEAAITPETKLV 154
Query: 151 LVETMTNPTLKVIDVPEVAKRCREVG-AILVVDNTFVTPLLYKPLEDGASYVVHSLTKYI 209
+ET TNPT KVID+ A + G ILVVDNTF++P +PL GA ++S TKY+
Sbjct: 155 WIETPTNPTQKVIDIEGCAHIVHKHGDIILVVDNTFMSPYFQRPLALGADISMYSATKYM 214
Query: 210 AGHNDVLGGAVLWNGEFSRDLWEW-RRRLGTIIQPFDAWMIERGMRTLEVRFERQSENAM 268
GH+DV+ G V N E + + + LG + P D ++ RG++TL VR E+ +N M
Sbjct: 215 NGHSDVVMGLVSVNCESLHNRLRFLQNSLGAVPSPIDCYLCNRGLKTLHVRMEKHFKNGM 274
Query: 269 AIAEFLKDHPKVREVHYPGLKDDPYYKVARRLFKKDLYGGVVAFDLGSGDNALAFLRGLK 328
A+A+FL+ +P V +V YPGL P +++ +R G V + G+ +A FL+ LK
Sbjct: 275 AVAQFLESNPWVEKVIYPGLPSHPQHELVKRQCT-GCTGMVTFYIKGTLQHAEIFLKNLK 333
Query: 329 RIFPSPSLGGVESIATYPVKSAAKTLDEEIREILGITDGLIRLSVGLEPLDELIEDIDNA 388
+ SLGG ES+A P ++ + R++LGI+D LIRLSVGLE ++L+ED+D A
Sbjct: 334 LFTLAESLGGFESLAELPAIMTHASVLKNDRDVLGISDTLIRLSVGLEDEEDLLEDLDQA 393
Query: 389 L 389
L
Sbjct: 394 L 394
>sp|P53780|METC_ARATH CYSTATHIONINE BETA-LYASE PRECURSOR (CBL) (BETA-CYSTATHIONASE)
(CYSTEINE LYASE) >gi|2129567|pir||S61429 cystathionine
beta-lyase (EC 4.4.1.8) precursor - Arabidopsis thaliana
>gi|704397|gb|AAA99176.1| (L40511) cystathionine
beta-lyase [Arabidopsis thaliana]
>gi|6911875|emb|CAB72175.1| (AL138655) CYSTATHIONINE
BETA-LYASE PRECURSOR (CBL) [Arabidopsis thaliana]
Length = 464
Score = 216 bits (544), Expect = 4e-55
Identities = 128/361 (35%), Positives = 214/361 (58%), Gaps = 14/361 (3%)
Query: 33 PLYITAVFKQVG--DAYPTDRGTELKYSREENPTVRKLEDKLAELEGSDNALAFNSGMSA 90
PLY TA FKQ + P D Y+R NPT LE LA+L+ +D A F SGM+A
Sbjct: 107 PLYQTATFKQPSAIENGPYD------YTRSGNPTRDALESLLAKLDKADRAFCFTSGMAA 160
Query: 91 ISTLYFSLLEGGDKVVLSMEGYGTTIEL-AKLLRKFGVDVKLAYPSA-DSLIETIDEETK 148
+S + L++ G+++V + YG + L ++++ + GV VK + D + I +TK
Sbjct: 161 LSAVTH-LIKNGEEIVAGDDVYGGSDRLLSQVVPRSGVVVKRVNTTKLDEVAAAIGPQTK 219
Query: 149 LVLVETMTNPTLKVIDVPEVAKRCREVGAILVVDNTFVTPLLYKPLEDGASYVVHSLTKY 208
LV +E+ TNP ++ D+ ++++ GA+++VDN+ ++P+L +PLE GA V+HS TK+
Sbjct: 220 LVWLESPTNPRQQISDIRKISEMAHAQGALVLVDNSIMSPVLSRPLELGADIVMHSATKF 279
Query: 209 IAGHNDVLGGAVLWNGE-FSRDLWEWRRRLGTIIQPFDAWMIERGMRTLEVRFERQSENA 267
IAGH+DV+ G + GE +++++ + G+ + PFD W+ RG++T+ +R E+Q ENA
Sbjct: 280 IAGHSDVMAGVLAVKGEKLAKEVYFLQNSEGSGLAPFDCWLCLRGIKTMALRIEKQQENA 339
Query: 268 MAIAEFLKDHPKVREVHYPGLKDDPYYKVARRLFKKDLYGGVVAFDLGSGDNALAFLRGL 327
IA +L HP+V++V+Y GL D P + + + G V +F GS + +
Sbjct: 340 RKIAMYLSSHPRVKKVYYAGLPDHPGHHL--HFSQAKGAGSVFSFITGSVALSKHLVETT 397
Query: 328 KRIFPSPSLGGVESIATYPVKSAAKTLDEEIREILGITDGLIRLSVGLEPLDELIEDIDN 387
K + S G V+S+ + P + ++ E+RE G+T+ L+R+S G+E +D+LI D+D
Sbjct: 398 KYFSIAVSFGSVKSLISMPCFMSHASIPAEVREARGLTEDLVRISAGIEDVDDLISDLDI 457
Query: 388 A 388
A
Sbjct: 458 A 458
>sp|P55217|METB_ARATH CYSTATHIONINE GAMMA-SYNTHASE, CHLOROPLAST PRECURSOR (CGS)
(O-SUCCINYLHOMOSERINE (THIOL)-LYASE)
>gi|3293261|gb|AAC25687.1| (AF039206) cystathionine
gamma-synthase precursor [Arabidopsis thaliana]
Length = 563
Score = 216 bits (544), Expect = 4e-55
Identities = 128/346 (36%), Positives = 195/346 (55%), Gaps = 6/346 (1%)
Query: 51 RGTELKYSREENPTVRKLEDKLAELEGSDNALAFNSGMSAISTLYFSLLEGGDKVVLSME 110
R +Y R NPT LEDK++ LEG+++ L SGM A + + +L+ G +V + +
Sbjct: 220 RSVSFEYGRYGNPTTVVLEDKISALEGAESTLVMASGMCASTVMLLALVPAGGHIVTTTD 279
Query: 111 GYGTT-IELAKLLRKFGVDVKLAYPSADSLIETIDEETKLVL--VETMTNPTLKVIDVPE 167
Y T I + L K G+ V + P+ + +E E K+ L E+ TNP L+ +D+
Sbjct: 280 CYRKTRIFMENFLPKLGITVTVIDPADIAGLEAAVNEFKVSLFFTESPTNPFLRCVDIEL 339
Query: 168 VAKRCREVGAILVVDNTFVTPLLYKPLEDGASYVVHSLTKYIAGHNDVLGGAVLWNGEFS 227
V+K C + G ++ +D TF TPL K L GA VVHS TKYI GHNDVL G + + +
Sbjct: 340 VSKICHKRGTLVCIDGTFATPLNQKALALGADLVVHSATKYIGGHNDVLAGCICGSLKLV 399
Query: 228 RDLWEWRRRLGTIIQPFDAWMIERGMRTLEVRFERQSENAMAIAEFLKDHPKVREVHYPG 287
++ LG + P A++I RGM+TL +R ++Q+ A +AE L+ HPKV V+YPG
Sbjct: 400 SEIRNLHHVLGGPLNPNAAYLIIRGMKTLHLRVQQQNSTAFRMAEILEAHPKVSHVYYPG 459
Query: 288 LKDDPYYKVARRLFKKDLYGGVVAFDL-GSGDNALAFLRGLKRIFPSPSLGGVESIATYP 346
L P +++A+R + +GGVV+F++ G + + F+ LK + +PS GG ESI P
Sbjct: 460 LPSHPEHELAKR--QMTGFGGVVSFEIDGDIETTIKFVDSLKIPYIAPSFGGCESIVDQP 517
Query: 347 VKSAAKTLDEEIREILGITDGLIRLSVGLEPLDELIEDIDNALGVV 392
+ L +E R GI D L+R S G+E +++ DI AL +
Sbjct: 518 AIMSYWDLPQEERLKYGIKDNLVRFSFGVEDFEDVKADILQALEAI 563
>dbj|BAA95820.1| (AP002069) EST AU082557(R0845) corresponds to a region of the
predicted gene.~Similar to Arabidopsis thaliana
cystathionine beta-lyase precursor (P53780) [Oryza
sativa]
Length = 475
Score = 215 bits (543), Expect = 5e-55
Identities = 132/364 (36%), Positives = 213/364 (58%), Gaps = 18/364 (4%)
Query: 33 PLYITAVFKQVGDAYPTDRGTELKYSREENPTVRKLEDKLAELEGSDNALAFNSGMSAIS 92
PLY TA FKQ TD G Y+R NPT L+ +A+LE +D A F SGM+A++
Sbjct: 118 PLYQTATFKQPS---ATDNGP-YDYTRSGNPTRDVLQSLMAKLEKADQAFCFTSGMAALA 173
Query: 93 TLYFSLLEGGDKVVLSMEGYGTTIEL-AKLLRKFGVDVK-LAYPSADSLIETIDEETKLV 150
+ LL+ G ++V + YG + L +++ + G+ VK + + I TKLV
Sbjct: 174 AVTH-LLKSGQEIVAGEDIYGGSDRLLSQVAPRHGIVVKRIDTTKISEVTSAIGPLTKLV 232
Query: 151 LVETMTNPTLKVIDVPEVAKRCREVGAILVVDNTFVTPLLYKPLEDGASYVVHSLTKYIA 210
+E+ TNP L++ D+ ++A+ GA+++VDN+ ++P+L +PLE GA V+HS TK+IA
Sbjct: 233 WLESPTNPRLQITDIKKIAEIAHYHGALVLVDNSIMSPVLSRPLELGADIVMHSATKFIA 292
Query: 211 GHNDVLGGAVLWNGE-FSRDLWEWRRRLGTIIQPFDAWMIERGMRTLEVRFERQSENAMA 269
GH+D++ G + GE ++++ + G+ + PFD W+ RG++T+ +R E+Q NA
Sbjct: 293 GHSDLMAGILAVKGESLAKEIAFLQNAEGSGLAPFDCWLCLRGIKTMALRVEKQQANAQK 352
Query: 270 IAEFLKDHPKVREVHYPGLKDDP----YYKVARRLFKKDLYGGVVAFDLGSGDNALAFLR 325
IAEFL HP+V++V+Y GL D P +Y A+ G V++F GS + +
Sbjct: 353 IAEFLASHPRVKKVNYAGLPDHPGRSLHYSQAKGA------GSVLSFLTGSLALSKHVVE 406
Query: 326 GLKRIFPSPSLGGVESIATYPVKSAAKTLDEEIREILGITDGLIRLSVGLEPLDELIEDI 385
K + S G V+S+ + P + ++ +RE G+TD L+R+SVG+E D+LI D+
Sbjct: 407 TTKYFNVTVSFGSVKSLISLPCFMSHASIPSAVREERGLTDDLVRISVGIEDADDLIADL 466
Query: 386 DNAL 389
D+AL
Sbjct: 467 DHAL 470
>dbj|BAA95830.1| (AP002069) EST AU082557(R0845) corresponds to a region of the
predicted gene.~Similar to Arabidopsis thaliana
cystathionine beta-lyase precursor (P53780) [Oryza
sativa]
Length = 383
Score = 215 bits (543), Expect = 5e-55
Identities = 132/364 (36%), Positives = 213/364 (58%), Gaps = 18/364 (4%)
Query: 33 PLYITAVFKQVGDAYPTDRGTELKYSREENPTVRKLEDKLAELEGSDNALAFNSGMSAIS 92
PLY TA FKQ TD G Y+R NPT L+ +A+LE +D A F SGM+A++
Sbjct: 26 PLYQTATFKQPS---ATDNGP-YDYTRSGNPTRDVLQSLMAKLEKADQAFCFTSGMAALA 81
Query: 93 TLYFSLLEGGDKVVLSMEGYGTTIEL-AKLLRKFGVDVK-LAYPSADSLIETIDEETKLV 150
+ LL+ G ++V + YG + L +++ + G+ VK + + I TKLV
Sbjct: 82 AVTH-LLKSGQEIVAGEDIYGGSDRLLSQVAPRHGIVVKRIDTTKISEVTSAIGPLTKLV 140
Query: 151 LVETMTNPTLKVIDVPEVAKRCREVGAILVVDNTFVTPLLYKPLEDGASYVVHSLTKYIA 210
+E+ TNP L++ D+ ++A+ GA+++VDN+ ++P+L +PLE GA V+HS TK+IA
Sbjct: 141 WLESPTNPRLQITDIKKIAEIAHYHGALVLVDNSIMSPVLSRPLELGADIVMHSATKFIA 200
Query: 211 GHNDVLGGAVLWNGE-FSRDLWEWRRRLGTIIQPFDAWMIERGMRTLEVRFERQSENAMA 269
GH+D++ G + GE ++++ + G+ + PFD W+ RG++T+ +R E+Q NA
Sbjct: 201 GHSDLMAGILAVKGESLAKEIAFLQNAEGSGLAPFDCWLCLRGIKTMALRVEKQQANAQK 260
Query: 270 IAEFLKDHPKVREVHYPGLKDDP----YYKVARRLFKKDLYGGVVAFDLGSGDNALAFLR 325
IAEFL HP+V++V+Y GL D P +Y A+ G V++F GS + +
Sbjct: 261 IAEFLASHPRVKKVNYAGLPDHPGRSLHYSQAKGA------GSVLSFLTGSLALSKHVVE 314
Query: 326 GLKRIFPSPSLGGVESIATYPVKSAAKTLDEEIREILGITDGLIRLSVGLEPLDELIEDI 385
K + S G V+S+ + P + ++ +RE G+TD L+R+SVG+E D+LI D+
Sbjct: 315 TTKYFNVTVSFGSVKSLISLPCFMSHASIPSAVREERGLTDDLVRISVGIEDADDLIADL 374
Query: 386 DNAL 389
D+AL
Sbjct: 375 DHAL 378
>pir||T44655 O-acetylhomoserine (thiol)-lyase (EC 4.2.99.10) [imported] -
Leptospira meyeri >gi|1835113|emb|CAA71732.1| (Y10744)
O-acetylhomoserine sulfhydrylase [Leptospira meyeri]
Length = 442
Score = 215 bits (543), Expect = 5e-55
Identities = 131/376 (34%), Positives = 197/376 (51%), Gaps = 43/376 (11%)
Query: 57 YSREENPTVRKLEDKLAELEGSDNALAFNSGMSAISTLYFSLLEGGDKVVLSMEGYGTTI 116
Y+R NPT LE ++A LEG ALA SG SA +++E G ++V S YG T
Sbjct: 64 YTRLMNPTTDVLEKRVAALEGGVAALATASGQSAEMLALLNIVEAGQEIVASSSLYGGTY 123
Query: 117 ELAKL-LRKFGVDVKLAYPS-ADSLIETIDEETKLVLVETMTNPTLKVIDVPEVAKRCRE 174
L K G+ V S ++ + +++T+ ET+ NP L +D+ V+K +E
Sbjct: 124 NLLHYTFPKLGIKVHFVDQSDPENFRKASNDKTRAFYAETLGNPKLDTLDIAAVSKVAKE 183
Query: 175 VGAILVVDNTFVTPLLYKPLEDGASYVVHSLTKYIAGHNDVLGGAVL------W-NGEFS 227
VG LV+DNT +P L PL+ GA VVHSLTK++ GH +GG ++ W NG+F
Sbjct: 184 VGVPLVIDNTMPSPYLVNPLKHGADIVVHSLTKFLGGHGTSIGGIIIDGGSFNWGNGKFK 243
Query: 228 R-----------DLWE----------------------WRRRLGTIIQPFDAWMIERGMR 254
WE R LG I PF+AW I +G+
Sbjct: 244 NFTEPDPSYHGLKFWEVFGKFEPFGGVNIAFILKARVQGLRDLGPAISPFNAWQILQGVE 303
Query: 255 TLEVRFERQSENAMAIAEFLKDHPKVREVHYPGLKDDPYYKVARRLFKKDLYGGVVAFDL 314
TL +R ER S NA+ +AEFL+ HPK+ V+YPGL D Y A++ ++ L+G +V F++
Sbjct: 304 TLPLRMERHSGNALKVAEFLQKHPKIEWVNYPGLSTDKNYATAKKYHERGLFGAIVGFEI 363
Query: 315 GSG-DNALAFLRGLKRIFPSPSLGGVESIATYPVKSAAKTLDEEIREILGITDGLIRLSV 373
G + A F+ GL+ ++G +S+A +P + + L + G+T G +RLSV
Sbjct: 364 KGGVEKAKKFIDGLELFSLLANIGDAKSLAIHPASTTHQQLTGPEQISAGVTPGFVRLSV 423
Query: 374 GLEPLDELIEDIDNAL 389
GLE +D+++ D++ AL
Sbjct: 424 GLENIDDILVDLEEAL 439
>emb|CAC05298.1| (AJ293860) cystathionine beta-lyase [Lactobacillus reuteri]
Length = 380
Score = 215 bits (542), Expect = 7e-55
Identities = 131/360 (36%), Positives = 201/360 (55%), Gaps = 10/360 (2%)
Query: 33 PLYITAVFKQVGDAYPTDRGTELKYSREENPTVRKLEDKLAELEGSDNALAFNSGMSAIS 92
P+Y ++ F Q + + +YSR NPT LE +AELE AF SG +AI
Sbjct: 24 PIYRSSTFHQ----HVLGGEPKWEYSRTGNPTRVSLEKLIAELEHGTVGFAFASGSAAIH 79
Query: 93 TLYFSLLEGGDKVVLSMEGYGTTIELA-KLLRKFGVDVKLA-YPSADSLIETIDEETKLV 150
FSL GD V+ + YG T L K+L++FG + + +++ I + T V
Sbjct: 80 AT-FSLFSQGDHFVVGSDVYGGTFRLINKVLKRFGFEFTVVDMQDLEAVENAIQDNTVAV 138
Query: 151 LVETMTNPTLKVIDVPEVAKRCREVGAILVVDNTFVTPLLYKPLEDGASYVVHSLTKYIA 210
ET TNP L++ D+ +A ++ G +VDNTF TP +PL GA VVHS TKY+
Sbjct: 139 YFETPTNPLLQIADIKAIADIAKKHGVKTIVDNTFATPYNQQPLTLGADIVVHSATKYLG 198
Query: 211 GHNDVLGG-AVLWNGEFSRDLWEWRRRLGTIIQPFDAWMIERGMRTLEVRFERQSENAMA 269
GH+DV+ G AV + E + L + +G+ + P D+W+++RGM+TL R ENA
Sbjct: 199 GHSDVVAGLAVTNDDEIAEQLAFLQNSIGSTLGPDDSWLLQRGMKTLGARMRVHQENANE 258
Query: 270 IAEFLKDHPKVREVHYPGLKDDPYYKVARRLFKKDLYGGVVAFDLGSGDNALAFLRGLKR 329
+ FL++ + +++YPGLKD P ++VA + + +G +++F+L +A F+ L+
Sbjct: 259 VINFLQNDDHIGKIYYPGLKDFPGHEVAAKQMRN--FGAMISFELKDSLDAKKFVESLQL 316
Query: 330 IFPSPSLGGVESIATYPVKSAAKTLDEEIREILGITDGLIRLSVGLEPLDELIEDIDNAL 389
I + SLGG+ES+ P ++ EIR GI D LIRLSVG+E +++I D+ AL
Sbjct: 317 IDLAESLGGIESLIEVPAVMTHGSIPREIRLENGIKDELIRLSVGIEDPEDIIADLQQAL 376
>gb|AAC49574.1| (U43709) similar to the metB gene product of Escherichia coli;
cloned by functional complementation of a metB mutant
strain of Escherichia coli LE392 [Arabidopsis thaliana]
Length = 563
Score = 214 bits (540), Expect = 1e-54
Identities = 127/346 (36%), Positives = 194/346 (55%), Gaps = 6/346 (1%)
Query: 51 RGTELKYSREENPTVRKLEDKLAELEGSDNALAFNSGMSAISTLYFSLLEGGDKVVLSME 110
R +Y R NPT LEDK++ LEG+++ L SGM A + + +L+ G +V + +
Sbjct: 220 RSVSFEYGRYGNPTTVVLEDKISALEGAESTLVMASGMCASTVMLLALVPAGGHIVTTTD 279
Query: 111 GYGTT-IELAKLLRKFGVDVKLAYPSADSLIETIDEETKLVL--VETMTNPTLKVIDVPE 167
Y T I + L K G+ V + P+ + +E E K+ L E+ TNP L+ +D+
Sbjct: 280 CYRKTRIFMENFLPKLGITVTVIDPADIAGLEAAVNEFKVSLFFTESPTNPFLRCVDIEL 339
Query: 168 VAKRCREVGAILVVDNTFVTPLLYKPLEDGASYVVHSLTKYIAGHNDVLGGAVLWNGEFS 227
V+K C + G ++ +D TF TPL K L GA VVHS TKYI GHNDVL G + + +
Sbjct: 340 VSKICHKRGTLVCIDGTFATPLNQKALALGADLVVHSATKYIGGHNDVLAGCICGSLKLV 399
Query: 228 RDLWEWRRRLGTIIQPFDAWMIERGMRTLEVRFERQSENAMAIAEFLKDHPKVREVHYPG 287
++ LG + P A++I RGM+TL +R ++Q+ A +AE L+ HPKV V+YP
Sbjct: 400 SEIRNLHHVLGGTLNPNAAYLIIRGMKTLHLRVQQQNSTAFRMAEILEAHPKVSHVYYPA 459
Query: 288 LKDDPYYKVARRLFKKDLYGGVVAFDL-GSGDNALAFLRGLKRIFPSPSLGGVESIATYP 346
L P +++A+R + +GGVV+F++ G + + F+ LK + +PS GG ESI P
Sbjct: 460 LPSHPEHELAKR--QMTGFGGVVSFEIDGDIETTIKFVDSLKIPYIAPSFGGCESIVDQP 517
Query: 347 VKSAAKTLDEEIREILGITDGLIRLSVGLEPLDELIEDIDNALGVV 392
+ L +E R GI D L+R S G+E +++ DI AL +
Sbjct: 518 AIMSYWDLPQEERLKYGIKDNLVRFSFGVEDFEDVKADILQALEAI 563
>pir||B81949 cystathionine beta-lyase (EC 4.4.1.8) NMA1012 [similarity] -
Neisseria meningitidis (group A strain Z2491)
>gi|7379714|emb|CAB84281.1| (AL162754) putative
carbon-sulphur lyase [Neisseria meningitidis Z2491]
Length = 385
Score = 214 bits (540), Expect = 1e-54
Identities = 131/389 (33%), Positives = 220/389 (55%), Gaps = 18/389 (4%)
Query: 9 YVEKDINLPWDQREGEIKMKPLHDPLYITAVFK--QVGDAYPTDRGTELKYSREENPTVR 66
+ K I+ +D E + P P+Y ++F ++G+ P +YSR NPT +
Sbjct: 3 FATKAIHSSYDCDEHNRALMP---PIYQNSMFALHEIGENVP------YRYSRLSNPTRQ 53
Query: 67 KLEDKLAELEGSDNALAFNSGMSAISTLYFSLLEGGDKVVLSMEGYGTTIEL-AKLLRKF 125
LED +A+LE AF+SGM+ I ++ + L+ GD +V + YG +L + +K+
Sbjct: 54 ILEDTVADLEHGAAGFAFSSGMAGIDAVWRTFLQPGDTIVAVADIYGGAYDLLVDVYQKW 113
Query: 126 GVDVKLA-YPSADSLIETID-EETKLVLVETMTNPTLKVIDVPEVAKRCREVGAILVVDN 183
GV+V A + D+L E + + KLV +ET +NP L+++D+ +A + + GA++ +DN
Sbjct: 114 GVNVVFADLGNPDNLDELLKAHKVKLVWLETPSNPLLRLVDIKALAAKAKAAGALVGIDN 173
Query: 184 TFVTPLLYKPLEDGASYVVHSLTKYIAGHNDVLGGAVL-WNGEFSRDLWEWRRRLGTIIQ 242
TF TP L +PL+ G +V HS TKY+ GH+DVL G V+ E ++ L + G +
Sbjct: 174 TFATPYLQQPLDMGCDFVFHSATKYLCGHSDVLMGIVVAKTKELAQPLHDMMVHTGAVAG 233
Query: 243 PFDAWMIERGMRTLEVRFERQSENAMAIAEFLKDHPKVREVHYPGLKDDPYYKVARRLFK 302
P D W++ RG++TL +R +NA+ IA L+ HP + +V +PGL +Y++A+
Sbjct: 234 PMDCWLVLRGIKTLALRMNAHYQNALEIARRLEAHPAIEKVFHPGLPSHEHYELAKTQMP 293
Query: 303 KDLYGGVVAFDL--GSGDNALAFLRGLKRIFPSPSLGGVESIATYPVKSAAKTLDEEIRE 360
K + GGVV L + + A + ++ +K + + SLGGVES+ + + + ++
Sbjct: 294 KGI-GGVVTVYLKNDTREAANSVIKNMKLVKMASSLGGVESLVNHCYSQSHSGVPHNVKM 352
Query: 361 ILGITDGLIRLSVGLEPLDELIEDIDNAL 389
+GI GL+R SVG+E +D++ DI AL
Sbjct: 353 EMGIRVGLLRFSVGIEDVDDIWNDISAAL 381
>pir||A81158 cystathionine beta-lyase (EC 4.4.1.8) NMB0802 [similarity] -
Neisseria meningitidis (group B strain MD58)
>gi|7226035|gb|AAF41215.1| (AE002433) cystathionine
gamma-synthase [Neisseria meningitidis MC58]
Length = 385
Score = 213 bits (537), Expect = 3e-54
Identities = 130/389 (33%), Positives = 219/389 (55%), Gaps = 18/389 (4%)
Query: 9 YVEKDINLPWDQREGEIKMKPLHDPLYITAVFK--QVGDAYPTDRGTELKYSREENPTVR 66
+ K I+ +D E + P P+Y ++F ++G+ P +YSR NPT +
Sbjct: 3 FATKAIHSSYDCDEHNRALMP---PIYQNSMFALHEIGENVP------YRYSRLSNPTRQ 53
Query: 67 KLEDKLAELEGSDNALAFNSGMSAISTLYFSLLEGGDKVVLSMEGYGTTIEL-AKLLRKF 125
LED +A+LE AF+SGM+ I ++ + L GD +V + YG +L + +K+
Sbjct: 54 ILEDTVADLEHGAAGFAFSSGMAGIDAVWRTFLRPGDTIVAVADIYGGAYDLLVDVYQKW 113
Query: 126 GVDVKLA-YPSADSLIETID-EETKLVLVETMTNPTLKVIDVPEVAKRCREVGAILVVDN 183
GV+V A + D+L E + + KLV +ET +NP L+++D+ +A + + GA++ +DN
Sbjct: 114 GVNVVFADLGNPDNLDELLKAHKVKLVWLETPSNPLLRLVDIKVLAAKAKAAGALVGIDN 173
Query: 184 TFVTPLLYKPLEDGASYVVHSLTKYIAGHNDVLGGAVL-WNGEFSRDLWEWRRRLGTIIQ 242
TF TP L +PL+ G +V HS TKY+ GH+DVL G V+ E ++ L + G +
Sbjct: 174 TFATPYLQQPLDMGCDFVFHSATKYLCGHSDVLMGIVVAKTKELAQPLHDMMVHTGAVAG 233
Query: 243 PFDAWMIERGMRTLEVRFERQSENAMAIAEFLKDHPKVREVHYPGLKDDPYYKVARRLFK 302
P D W++ RG++TL +R +NA+ IA L+ HP + +V +PGL +Y++A+
Sbjct: 234 PLDCWLVLRGIKTLALRMNAHCQNALEIARRLEAHPAIEKVFHPGLPSHEHYELAKTQMP 293
Query: 303 KDLYGGVVAFDL--GSGDNALAFLRGLKRIFPSPSLGGVESIATYPVKSAAKTLDEEIRE 360
K + GGVV L + + A + ++ +K + + SLGGVES+ + + + +++
Sbjct: 294 KGI-GGVVTVYLKNDTREAANSVIKNMKLVKMASSLGGVESLVNHCYSQSHSGVPHDVKM 352
Query: 361 ILGITDGLIRLSVGLEPLDELIEDIDNAL 389
+GI GL+R S+G+E D++ DI AL
Sbjct: 353 EMGIKVGLLRFSIGIEDADDIWNDISAAL 381
>pir||T02940 O-succinylhomoserine (thiol)-lyase (EC 4.2.99.9) 1 - maize
>gi|2198851|gb|AAB61347.1| (AF007785) cystathionine
gamma-synthase [Zea mays]
Length = 509
Score = 212 bits (535), Expect = 5e-54
Identities = 125/343 (36%), Positives = 194/343 (56%), Gaps = 7/343 (2%)
Query: 51 RGTELKYSREENPTVRKLEDKLAELEGSDNALAFNSGMSAISTLYFSLLEGGDKVVLSME 110
R +Y R NPT LE K++ LE +++ + SGM A + +L+ G +V + +
Sbjct: 167 RHASFEYGRYGNPTTEALEKKMSALEKAESTVFVASGMYAAVAMLSALVPAGGHIVTTTD 226
Query: 111 GYGTT-IELAKLLRKFGVDVKLAYPS-ADSLIETIDEET-KLVLVETMTNPTLKVIDVPE 167
Y T I + L K G+ + + P+ D+L +D L ET TNP L+ ID+
Sbjct: 227 CYRKTRIYMENELPKRGISMTVIRPADMDALQNALDNNNVSLFFTETPTNPFLRCIDIEH 286
Query: 168 VAKRCREVGAILVVDNTFVTPLLYKPLEDGASYVVHSLTKYIAGHNDVLGGAVLWNGEFS 227
V+ C GA+L +D+TF +P+ K L GA V+HS TKYIAGHNDV+GG V E
Sbjct: 287 VSNMCHSKGALLCIDSTFASPINQKALTLGADLVIHSATKYIAGHNDVIGGCVSGRDELV 346
Query: 228 RDLWEWRRRLGTIIQPFDAWMIERGMRTLEVRFERQSENAMAIAEFLKDHPKVREVHYPG 287
+ + +G ++ P A++I RGM+TL +R + Q++ A+ +A+FL++HPK+ V+YPG
Sbjct: 347 SKVRIYHHVVGGVLNPNAAYLILRGMKTLHLRVQCQNDTALRMAQFLEEHPKIARVYYPG 406
Query: 288 LKDDPYYKVARRLFKKDLYGGVVAFDL-GSGDNALAFLRGLKRIFPSPSLGGVESIATYP 346
L P + +A+ + +GGVV+F++ G D F+ +K + +PS GG ESI P
Sbjct: 407 LPSHPEHHIAKS--QMTGFGGVVSFEVAGDFDATRKFIDSVKIPYHAPSFGGCESIIDQP 464
Query: 347 VKSAAKTLDEEIREILGITDGLIRLSVGLEPLDELIEDIDNAL 389
+ E+ R+I GI D LIR S+G+E ++L D+ AL
Sbjct: 465 AIMSYWDSKEQ-RDIYGIKDNLIRFSIGVEDFEDLKNDLVQAL 506
>emb|CAA09983.1| (AJ012295) O-succinylhomoserine sulfhydrylase [Rhizobium etli]
Length = 394
Score = 212 bits (535), Expect = 5e-54
Identities = 136/367 (37%), Positives = 203/367 (55%), Gaps = 19/367 (5%)
Query: 38 AVFKQVGDAYPTDRGTELK---------YSREENPTVRKLEDKLAELEGSDNALAFNSGM 88
A++ G Y T E + Y+R +PT E ++ LEG+++A A SGM
Sbjct: 27 AIYLTQGFVYDTSEPAEARFKGETDGFIYARYGSPTNDMFEKRMCALEGAEDARATASGM 86
Query: 89 SAISTLYFSLLEGGDKVVLSMEGYGTTIELAKLLR-KFGVDVKLAYP-SADSLIETIDEE 146
+A++ ++ GD +V + +G+ + + L K+GV+ L + + I
Sbjct: 87 AAVAAAVLCQVKAGDHIVAARALFGSCRWVVETLAPKYGVECTLVDGRDLANWEKAIRPN 146
Query: 147 TKLVLVETMTNPTLKVIDVPEVAKRCREVGAILVVDNTFVTPLLYKPLEDGASYVVHSLT 206
TK+ +E+ TNPTL+V+D+ VAK +VGA L+VDN F TPL KPLE GA VV+S T
Sbjct: 147 TKVFFLESPTNPTLEVVDISGVAKLANQVGAKLIVDNVFATPLFQKPLELGAHIVVYSAT 206
Query: 207 KYIAGHNDVLGGAVLWNGEF-SRDLWEWRRRLGTIIQPFDAWMIERGMRTLEVRFERQSE 265
K+I G LGG VL + + +L ++ R G + PF+AW + +G+ TL +R +Q+E
Sbjct: 207 KHIDGQGACLGGVVLADKAWIDENLHDYFRHTGPAMSPFNAWTLLKGIETLPLRVRQQTE 266
Query: 266 NAMAIAEFLKDHPKVREVHYPGLKDDPYYKVARRLFKKDLYGG--VVAFDL-GSGDNALA 322
NA IA+FL + KV +V YPG KD P ++ K + GG +V F+L G + A A
Sbjct: 267 NAAKIADFLAEQGKVAKVIYPGRKDHPQAEI----IAKQMTGGSTLVCFELKGGKEAAFA 322
Query: 323 FLRGLKRIFPSPSLGGVESIATYPVKSAAKTLDEEIREILGITDGLIRLSVGLEPLDELI 382
L+ I S +LG +S+ T+P + K L EE R LGI+ G +RLS G+E D+LI
Sbjct: 323 LQNALEIIKISNNLGDTKSLITHPATTTHKNLTEEARAELGISPGTVRLSAGIEDTDDLI 382
Query: 383 EDIDNAL 389
ED L
Sbjct: 383 EDFARGL 389
>pir||S52983 probable cystathionine gamma-lyase (EC 4.4.1.1) - Erwinia herbicola
(fragment) >gi|765097|gb|AAA64984.1| (M87280)
transcription must start in the vector; putative ORF12
[Erwinia herbicola]
Length = 611
Score = 210 bits (530), Expect = 2e-53
Identities = 130/363 (35%), Positives = 199/363 (54%), Gaps = 13/363 (3%)
Query: 33 PLYITAVFKQVGDAYPTDRGTELKYSREENPTVRKLEDKLAELEGSDNALAFNSGMSAIS 92
P+Y T+ F Q + T +YSR NPT LE +AELEG AF SG++AIS
Sbjct: 255 PIYATSTFAQPAPG----QHTGYEYSRSGNPTRHALESAIAELEGGTRGYAFASGLAAIS 310
Query: 93 TLYFSLLEGGDKVVLSMEGYGTTIELAKLLRKFGVDVKLAYPSADSLI---ETIDEETKL 149
T+ LL+ +V + YG T L + +R+ +++++ D L I +T++
Sbjct: 311 TV-LELLDKDSHIVAIDDVYGGTYRLIENVRRRSTGLQVSWVKPDDLAGLEAAIRPDTRM 369
Query: 150 VLVETMTNPTLKVIDVPEVAKRCREVGAILVVDNTFVTPLLYKPLEDGASYVVHSLTKYI 209
+ VET TNP LK+ D+ +A+ R I V DNTF +PL+++PL G VVHS TKY+
Sbjct: 370 IWVETPTNPLLKLADLAAIAEIARRHNVISVADNTFASPLIHRPLTLGFDIVVHSATKYL 429
Query: 210 AGHNDVLGGAVLWNGE--FSRDLWEWRRRLGTIIQPFDAWMIERGMRTLEVRFERQSENA 267
GH+DV+ G + + L + +G ++ PF +++ RG+RTL +R ER S NA
Sbjct: 430 NGHSDVVAGLAVVGDRPALAEKLGYLQNAVGGVLDPFSSFLTLRGIRTLALRIERHSSNA 489
Query: 268 MAIAEFLKDHPKVREVHYPGLKDDPYYKVARRLFKKDLYGGVVAFDL-GSGDNALAFLRG 326
+A+A +L+ P+V +V +P L P Y +AR+ + GG+++ + G A +
Sbjct: 490 LALARWLEQQPQVEKVWFPWLTSHPQYALARQQMAQP--GGMISIVIKGDDQRAAEVISK 547
Query: 327 LKRIFPSPSLGGVESIATYPVKSAAKTLDEEIREILGITDGLIRLSVGLEPLDELIEDID 386
LK + SLGGVES+ + P ++ R GIT LIRLSVG+E +L+ D+
Sbjct: 548 LKLFTLAESLGGVESLVSQPFSMTHASIPLAQRLANGITPQLIRLSVGIEDEKDLLADLQ 607
Query: 387 NAL 389
AL
Sbjct: 608 QAL 610
>pdb|1QGN|A Chain A, Cystathionine Gamma-Synthase From Nicotiana Tabacum
>gi|5822271|pdb|1QGN|B Chain B, Cystathionine
Gamma-Synthase From Nicotiana Tabacum
>gi|5822272|pdb|1QGN|C Chain C, Cystathionine
Gamma-Synthase From Nicotiana Tabacum
>gi|5822273|pdb|1QGN|D Chain D, Cystathionine
Gamma-Synthase From Nicotiana Tabacum
>gi|5822274|pdb|1QGN|E Chain E, Cystathionine
Gamma-Synthase From Nicotiana Tabacum
>gi|5822275|pdb|1QGN|F Chain F, Cystathionine
Gamma-Synthase From Nicotiana Tabacum
>gi|5822276|pdb|1QGN|G Chain G, Cystathionine
Gamma-Synthase From Nicotiana Tabacum
>gi|5822277|pdb|1QGN|H Chain H, Cystathionine
Gamma-Synthase From Nicotiana Tabacum
>gi|4322948|gb|AAD16143.1| (AF097180) cystathionine
gamma-synthase precursor [Nicotiana tabacum]
Length = 445
Score = 210 bits (529), Expect = 2e-53
Identities = 125/344 (36%), Positives = 191/344 (55%), Gaps = 8/344 (2%)
Query: 51 RGTELKYSREENPTVRKLEDKLAELEGSDNALAFNSGMSAISTLYFSLLEGGDKVVLSME 110
R +Y R NPT LE+K++ LEG+++ L SGM A + + +L+ G +V + +
Sbjct: 102 RRASFEYGRYGNPTTVVLEEKISALEGAESTLLMASGMCASTVMLLALVPAGGHIVTTTD 161
Query: 111 GYGTT-IELAKLLRKFGVDVKLAYPSADSLIETIDEETK--LVLVETMTNPTLKVIDVPE 167
Y T I + +L K G+ + P+ +E + K L E+ TNP L+ +D+
Sbjct: 162 CYRKTRIFIETILPKMGITATVIDPADVGALELALNQKKVNLFFTESPTNPFLRCVDIEL 221
Query: 168 VAKRCREVGAILVVDNTFVTPLLYKPLEDGASYVVHSLTKYIAGHNDVLGGAVLWNGEFS 227
V+K C E GA++ +D TF TPL K L GA V+HS TK++ GHNDVL G + +
Sbjct: 222 VSKLCHEKGALVCIDGTFATPLNQKALALGADLVLHSATKFLGGHNDVLAGCISGPLKLV 281
Query: 228 RDLWEWRRRLGTIIQPFDAWMIERGMRTLEVRFERQSENAMAIAEFLKDHPKVREVHYPG 287
++ LG + P A++I RGM+TL +R ++Q+ A+ +AE L+ HPKVR V+YPG
Sbjct: 282 SEIRNLHHILGGALNPNAAYLIIRGMKTLHLRVQQQNSTALRMAEILEAHPKVRHVYYPG 341
Query: 288 LKDDPYYKVARRLFKKDLYGGVVAFDLGSGD--NALAFLRGLKRIFPSPSLGGVESIATY 345
L+ P + +A++ + +GG V+F++ GD F+ LK + +PS GG ESI
Sbjct: 342 LQSHPEHHIAKK--QMTGFGGAVSFEV-DGDLLTTAKFVDALKIPYIAPSFGGCESIVDQ 398
Query: 346 PVKSAAKTLDEEIREILGITDGLIRLSVGLEPLDELIEDIDNAL 389
P + L + R GI D L+R S G+E D+L DI AL
Sbjct: 399 PAIMSYWDLSQSDRAKYGIMDNLVRFSFGVEDFDDLKADILQAL 442
>sp|P00935|METB_ECOLI CYSTATHIONINE GAMMA-SYNTHASE (CGS) (O-SUCCINYLHOMOSERINE
(THIOL)-LYASE) >gi|68356|pir||SYECCG
O-succinylhomoserine (thiol)-lyase (EC 4.2.99.9) -
Escherichia coli >gi|146846|gb|AAA24167.1| (K01547)
cystathione gamma-synthase [Escherichia coli]
>gi|305042|gb|AAB03071.1| (L19201) cystathionine
gamma-synthase [Escherichia coli]
>gi|1790375|gb|AAC76921.1| (AE000468) cystathionine
gamma-synthase [Escherichia coli K12]
Length = 386
Score = 209 bits (527), Expect = 4e-53
Identities = 128/359 (35%), Positives = 203/359 (55%), Gaps = 10/359 (2%)
Query: 33 PLYITAVFKQVGDAYPTDRGTELKYSREENPTVRKLEDKLAELEGSDNALAFNSGMSAIS 92
P+++++ + G P YSR NPT ++ LAELEG A+ N+GMSAI
Sbjct: 26 PIHLSSTYNFTGFNEPRAHD----YSRRGNPTRDVVQRALAELEGGAGAVLTNTGMSAIH 81
Query: 93 TLYFSLLEGGDKVVLSMEGYGTTIELAKLLRKFGVDVKLAYPSAD--SLIETIDEETKLV 150
+ L+ GD +V + YG + L L K G L D +L + E+ KLV
Sbjct: 82 LVTTVFLKPGDLLVAPHDCYGGSYRLFDSLAKRGCYRVLFVDQGDEQALRAALAEKPKLV 141
Query: 151 LVETMTNPTLKVIDVPEVAKRCREVGAILVVDNTFVTPLLYKPLEDGASYVVHSLTKYIA 210
LVE+ +NP L+V+D+ ++ REVGA+ VVDNTF++P L PL GA V+HS TKY+
Sbjct: 142 LVESPSNPLLRVVDIAKICHLAREVGAVSVVDNTFLSPALQNPLALGADLVLHSCTKYLN 201
Query: 211 GHNDVLGGAVL-WNGEFSRDLWEWRRRLGTIIQPFDAWMIERGMRTLEVRFERQSENAMA 269
GH+DV+ G V+ + + +L W +G FD++++ RG+RTL R E NA A
Sbjct: 202 GHSDVVAGVVIAKDPDVVTELAWWANNIGVTGGAFDSYLLLRGLRTLVPRMELAQRNAQA 261
Query: 270 IAEFLKDHPKVREVHYPGLKDDPYYKVARRLFKKDLYGGVVAFDLGSGDNAL-AFLRGLK 328
I ++L+ P V+++++P L ++ +++A R K +G +++F+L + L FL GL
Sbjct: 262 IVKYLQTQPLVKKLYHPSLPENQGHEIAARQQKG--FGAMLSFELDGDEQTLRRFLGGLS 319
Query: 329 RIFPSPSLGGVESIATYPVKSAAKTLDEEIREILGITDGLIRLSVGLEPLDELIEDIDN 387
+ SLGGVES+ ++ + E R GI++ L+R+S G+E ++LI D++N
Sbjct: 320 LFTLAESLGGVESLISHAATMTHAGMAPEARAAAGISETLLRISTGIEDGEDLIADLEN 378
>gb|AAF74981.1|AF082891_1 (AF082891) cystathionine gamma-synthase isoform 1 [Solanum
tuberosum]
Length = 539
Score = 209 bits (527), Expect = 4e-53
Identities = 123/344 (35%), Positives = 192/344 (55%), Gaps = 8/344 (2%)
Query: 51 RGTELKYSREENPTVRKLEDKLAELEGSDNALAFNSGMSAISTLYFSLLEGGDKVVLSME 110
R +Y R NPT LE+K++ LEG+++ L SGM A + ++ +L+ G +V + +
Sbjct: 196 RRASFEYGRYGNPTTVVLEEKISALEGAESTLIVASGMCASTVMFLALVPAGGHIVTTTD 255
Query: 111 GYGTT-IELAKLLRKFGVDVKLAYPSADSLIETIDEETK--LVLVETMTNPTLKVIDVPE 167
Y T + + +L K G+ + P+ +E + K L E+ TNP L+ +D+
Sbjct: 256 CYRKTRVFIETILPKMGITATVIDPADMGALELTLNQKKVDLFFTESPTNPFLRCVDIEL 315
Query: 168 VAKRCREVGAILVVDNTFVTPLLYKPLEDGASYVVHSLTKYIAGHNDVLGGAVLWNGEFS 227
V+K CRE GA++ +D TF TPL K L GA VVHS TK++ GHNDVL G + +
Sbjct: 316 VSKLCREKGALVCIDGTFATPLNQKALALGADLVVHSATKFLGGHNDVLAGCISGPEKLV 375
Query: 228 RDLWEWRRRLGTIIQPFDAWMIERGMRTLEVRFERQSENAMAIAEFLKDHPKVREVHYPG 287
+ LG + P A++I RGM+TL +R ++Q+ A+ +AE L+ HPKV+ V+YPG
Sbjct: 376 SVIRNLHHILGGALNPNAAYLIIRGMKTLHLRVQQQNSTALRMAEILEAHPKVKHVYYPG 435
Query: 288 LKDDPYYKVARRLFKKDLYGGVVAFDLGSGD--NALAFLRGLKRIFPSPSLGGVESIATY 345
L P Y +A++ + +GGVV+F++ GD F+ L+ + +PS GG ESI
Sbjct: 436 LPSHPEYHLAKK--QMTGFGGVVSFEV-DGDLLTTAKFVDALRIPYIAPSFGGCESIVDQ 492
Query: 346 PVKSAAKTLDEEIREILGITDGLIRLSVGLEPLDELIEDIDNAL 389
P + L + R GI D L+R S G+E +++ D+ AL
Sbjct: 493 PAIMSYWDLSQSDRAKYGILDNLVRFSFGVEDFEDVKADVLQAL 536
>gb|AAG38873.1|AF076495_1 (AF076495) cystathionine gamma-synthase [Oryza sativa]
Length = 360
Score = 209 bits (527), Expect = 4e-53
Identities = 126/343 (36%), Positives = 192/343 (55%), Gaps = 7/343 (2%)
Query: 51 RGTELKYSREENPTVRKLEDKLAELEGSDNALAFNSGMSAISTLYFSLLEGGDKVVLSME 110
R +Y R NPT LE K++ LE +++ + SGM A + +L+ G VV + +
Sbjct: 18 RHASFEYGRYGNPTTEALEKKMSALEKAESTVFVASGMYASVAMLSALVPAGGHVVTTTD 77
Query: 111 GYGTT-IELAKLLRKFGVDVKLAYPS-ADSLIETIDEET-KLVLVETMTNPTLKVIDVPE 167
Y T I + L K + + P+ D+L +D L ET TNP L+ ID+
Sbjct: 78 CYRKTRIYMETELPKTKSQMTVIRPADMDALQNALDNNNVSLFFTETPTNPFLRCIDIDL 137
Query: 168 VAKRCREVGAILVVDNTFVTPLLYKPLEDGASYVVHSLTKYIAGHNDVLGGAVLWNGEFS 227
V+K C GA+L +D+TF +P+ K L GA V+HS TKYIAGHNDV+GG + E
Sbjct: 138 VSKMCHSKGALLCIDSTFASPINQKALTLGADLVIHSATKYIAGHNDVIGGCISGRDELV 197
Query: 228 RDLWEWRRRLGTIIQPFDAWMIERGMRTLEVRFERQSENAMAIAEFLKDHPKVREVHYPG 287
+ + +G ++ P A++I RGM+TL +R + Q+ AM +A+FL++HPK+ V+YPG
Sbjct: 198 SKVRIYHHVVGGVLNPNAAYLILRGMKTLHLRVQCQNNTAMRMAQFLEEHPKIARVYYPG 257
Query: 288 LKDDPYYKVARRLFKKDLYGGVVAFDL-GSGDNALAFLRGLKRIFPSPSLGGVESIATYP 346
L P + +A+ + +GGV++F++ G D F+ +K + +PS GG ESI P
Sbjct: 258 LPSHPEHHIAKS--QMTGFGGVISFEVAGDFDATRRFIDSVKIPYHAPSFGGCESIIDQP 315
Query: 347 VKSAAKTLDEEIREILGITDGLIRLSVGLEPLDELIEDIDNAL 389
+ E+ REI GI D LIR S+G+E ++L D+ AL
Sbjct: 316 AIMSYWDSKEQ-REIYGIKDNLIRFSIGVEDFEDLKNDVVQAL 357
>gb|AAC83351.1| (AF092918) MetZ homolog [Pseudomonas alcaligenes]
Length = 391
Score = 209 bits (526), Expect = 5e-53
Identities = 126/370 (34%), Positives = 207/370 (55%), Gaps = 13/370 (3%)
Query: 32 DPLYITA--VFKQVGDAYPTDRGTELK--YSREENPTVRKLEDKLAELEGSDNALAFNSG 87
+ +++T+ VF+ DA G + YSR NPTVR E+++A LEG++ A+A SG
Sbjct: 26 EAMFLTSSYVFRSAADAAARFAGEQPGNVYSRYTNPTVRAFEERIAALEGAEQAVATASG 85
Query: 88 MSAISTLYFSLLEGGDKVVLSMEGYGTTIEL-AKLLRKFGVDVKLAYP---SADSLIETI 143
M+AI + SL GD V++S +G+TI L K L++FG++V YP D+
Sbjct: 86 MAAILAIVMSLCSAGDHVLVSRSVFGSTISLFEKYLKRFGIEVD--YPPLADLDAWQAAF 143
Query: 144 DEETKLVLVETMTNPTLKVIDVPEVAKRCREVGAILVVDNTFVTPLLYKPLEDGASYVVH 203
TKL+ VE+ +NP +++D+ +A+ GA+L VDN F TP L +PL GA V+H
Sbjct: 144 KPNTKLLFVESPSNPLAELVDIGALAEIAHARGALLAVDNCFCTPALQQPLALGADMVMH 203
Query: 204 SLTKYIAGHNDVLGGAVLWNGEFSRDLWEWRRRLGTIIQPFDAWMIERGMRTLEVRFERQ 263
S TK+I G LGG V + + R G + PF+AWM +G+ TL +R + Q
Sbjct: 204 SATKFIDGQGRGLGGVVAGRRAQMEQVVGFLRTAGPTLSPFNAWMFLKGLETLRIRMQAQ 263
Query: 264 SENAMAIAEFLKDHPKVREVHYPGLKDDPYYKVARRLFKKDLYGGVVAFDL-GSGDNALA 322
S +A+ +A +L+ P + V+Y GL P +++A+R ++ +G V++F++ G + A
Sbjct: 264 SASALELARWLETQPGIDRVYYAGLPSHPQHELAKR--QQSAFGAVLSFEVKGGKEAAWR 321
Query: 323 FLRGLKRIFPSPSLGGVESIATYPVKSAAKTLDEEIREILGITDGLIRLSVGLEPLDELI 382
F+ + I + +LG ++ +P ++ L + R GI D L+R++VGLE + +L
Sbjct: 322 FIDATRVISITTNLGDTKTTIAHPATTSHGRLSPQERASAGIRDNLVRVAVGLEDVVDLK 381
Query: 383 EDIDNALGVV 392
D+ L +
Sbjct: 382 ADLARGLAAL 391
>gi|8393215 CTL target antigen [Rattus norvegicus]
>gi|1705789|sp|P18757|CGL_RAT CYSTATHIONINE GAMMA-LYASE
(GAMMA-CYSTATHIONASE) (PROBASIN-RELATED ANTIGEN)
(PRB-RA) >gi|1083636|pir||A49864 cystathionine
gamma-lyase (EC 4.4.1.1) - rat
>gi|443705|dbj|BAA04189.1| (D17370) cystathionine
gamma-lyase [Rattus norvegicus]
Length = 398
Score = 209 bits (526), Expect = 5e-53
Identities = 135/362 (37%), Positives = 208/362 (57%), Gaps = 12/362 (3%)
Query: 33 PLYITAVFKQVGDAYPTDRGTELKYSREENPTVRKLEDKLAELEGSDNALAFNSGMSAIS 92
P+ + FKQ + + YSR NPT LE +A L+G+ + L F G++A +
Sbjct: 39 PISLATTFKQDSPG----QSSGFVYSRSGNPTRNCLEKAVAALDGAKHCLTFARGLAATT 94
Query: 93 TLYFSLLEGGDKVVLSMEGYGTTIE-LAKLLRKFGVDVKLAYPSADSLIET-IDEETKLV 150
T+ LL+ GD+V+ E YG T ++ +FG+ + S L+E I +TKLV
Sbjct: 95 TITH-LLKAGDEVICMDEVYGGTNRYFRRVASEFGLKISFVDCSKTKLLEAAITPQTKLV 153
Query: 151 LVETMTNPTLKVIDVPEVAKRC-REVGAILVVDNTFVTPLLYKPLEDGASYVVHSLTKYI 209
+ET TNPTLK+ D+ A+ + ILVVDNTF++ +PL GA + S TKY+
Sbjct: 154 WIETPTNPTLKLADIKACAQIVHKHKDIILVVDNTFMSAYFQRPLALGADICMCSATKYM 213
Query: 210 AGHNDVLGGAV-LWNGEFSRDLWEWRRRLGTIIQPFDAWMIERGMRTLEVRFERQSENAM 268
GH+DV+ G V + + + + L + LG + PFD ++ RG++TL++R E+ N M
Sbjct: 214 NGHSDVVMGLVSVTSDDLNERLRFLQNSLGAVPSPFDCYLCCRGLKTLQIRMEKHFRNGM 273
Query: 269 AIAEFLKDHPKVREVHYPGLKDDPYYKVARRLFKKDLYGGVVAFDL-GSGDNALAFLRGL 327
A+A FL+ +P+V +V YPGL P +++A+R + G+V+F + G+ +A FL+ +
Sbjct: 274 AVARFLESNPRVEKVIYPGLPSHPQHELAKR--QCTGCPGMVSFYIKGTLQHAQVFLKNI 331
Query: 328 KRIFPSPSLGGVESIATYPVKSAAKTLDEEIREILGITDGLIRLSVGLEPLDELIEDIDN 387
K + SLGG ES+A P ++ E+ R LGI+D LIRLSVGLE +L+ED+
Sbjct: 332 KLFALAESLGGYESLAELPAIMTHASVPEKDRATLGISDTLIRLSVGLEDEKDLLEDLGQ 391
Query: 388 AL 389
AL
Sbjct: 392 AL 393
>pir||E83018 homocysteine synthase PA5025 [imported] - Pseudomonas aeruginosa
(strain PAO1) >gi|9951313|gb|AAG08410.1|AE004915_5
(AE004915) homocysteine synthase [Pseudomonas
aeruginosa]
Length = 425
Score = 208 bits (525), Expect = 7e-53
Identities = 128/370 (34%), Positives = 198/370 (52%), Gaps = 38/370 (10%)
Query: 57 YSREENPTVRKLEDKLAELEGSDNALAFNSGMSAISTLYFSLLEGGDKVVLSMEGYGTTI 116
Y+R NPT LE ++A LEG ALA SGM+AI+ ++ E GD +V + YG T
Sbjct: 52 YTRIMNPTNDVLEQRVAALEGGVGALAVASGMAAITYAIQTVAEAGDNIVSVAKLYGGTY 111
Query: 117 EL-AKLLRKFGVDVKLA-YPSADSLIETIDEETKLVLVETMTNPTLKVIDVPEVAKRCRE 174
L A L + G+ + A + +L IDE TK V ET+ NP +ID+ +A
Sbjct: 112 NLLAHTLPRIGIQARFAAHDDVAALEALIDERTKAVFCETIGNPAGNIIDLQALADAAHR 171
Query: 175 VGAILVVDNTFVTPLLYKPLEDGASYVVHSLTKYIAGHNDVLGGAVLWNGEFSRDLWEWR 234
G L+VDNT TP+L +P E GA VVHSLTKY+ GH +GG V+ +G+F + R
Sbjct: 172 HGVPLIVDNTVATPVLCRPFEHGADIVVHSLTKYMGGHGTSIGGIVVDSGKFDWAANKSR 231
Query: 235 ----------------------------------RRLGTIIQPFDAWMIERGMRTLEVRF 260
R +G + PF+A++I +G+ TL +R
Sbjct: 232 FPLLNTPDPSYHGVTYTEAFGPAAFIGRCRVVPLRNMGAALSPFNAFLILQGLETLALRM 291
Query: 261 ERQSENAMAIAEFLKDHPKVREVHYPGLKDDPYYKVARRLFKKDLYGGVVAFDLGSGDNA 320
ER +NA+A+A +L+ HP+V V Y GL D+P + +ARR + +++F + G A
Sbjct: 292 ERHCDNALAVARYLQQHPQVAWVKYAGLADNPEHALARR-YLGGRPAAILSFGIQGGSAA 350
Query: 321 LA-FLRGLKRIFPSPSLGGVESIATYPVKSAAKTLDEEIREILGITDGLIRLSVGLEPLD 379
A F+ LK + ++G +S+A +P + + L+ E G++D ++RLS+G+E +D
Sbjct: 351 GARFIDALKLVVRLVNIGDAKSLACHPASTTHRQLNAEELARAGVSDDMVRLSIGIEHID 410
Query: 380 ELIEDIDNAL 389
+++ D+D AL
Sbjct: 411 DILADLDQAL 420
>pir||T02942 O-succinylhomoserine (thiol)-lyase (EC 4.2.99.9) 1 - maize
>gi|2198853|gb|AAB61348.1| (AF007786) cystathionine
gamma-synthase [Zea mays]
Length = 509
Score = 208 bits (525), Expect = 7e-53
Identities = 124/343 (36%), Positives = 193/343 (56%), Gaps = 7/343 (2%)
Query: 51 RGTELKYSREENPTVRKLEDKLAELEGSDNALAFNSGMSAISTLYFSLLEGGDKVVLSME 110
R +Y R NPT LE K++ LE +++ + SGM A + + +L+ G +V + +
Sbjct: 167 RHASFEYGRYGNPTTEALEKKMSALEKAESTVFVASGMYAAAAMLSALVPAGGHIVTTTD 226
Query: 111 GYGTT-IELAKLLRKFGVDVKLAYPS-ADSLIETIDEET-KLVLVETMTNPTLKVIDVPE 167
Y T I + L K G+ + + P+ D+L +D L ET TNP L+ ID+
Sbjct: 227 CYRKTRIYMETELPKRGISMTVIRPADMDALQNALDNNNVSLFFTETPTNPFLRCIDIEH 286
Query: 168 VAKRCREVGAILVVDNTFVTPLLYKPLEDGASYVVHSLTKYIAGHNDVLGGAVLWNGEFS 227
V+ C GA+L +D+TF +P+ K L GA V+HS TKYIAGHNDV+GG V E
Sbjct: 287 VSNMCHSKGALLCIDSTFASPINQKALTLGADLVIHSATKYIAGHNDVIGGCVSGRDELV 346
Query: 228 RDLWEWRRRLGTIIQPFDAWMIERGMRTLEVRFERQSENAMAIAEFLKDHPKVREVHYPG 287
+ + +G ++ P A++I RGM+TL +R + Q+ A+ +A+FL++H K+ V+YPG
Sbjct: 347 SKVRIYHHVVGGVLNPNAAYLILRGMKTLHLRVQCQNNTALRMAQFLEEHLKIARVYYPG 406
Query: 288 LKDDPYYKVARRLFKKDLYGGVVAFDL-GSGDNALAFLRGLKRIFPSPSLGGVESIATYP 346
L P + +A+ + +GGVV+F++ G D F+ +K + +PS GG ESI P
Sbjct: 407 LPSHPEHHIAKS--QMTGFGGVVSFEVAGDFDATRKFIDSVKIPYHAPSFGGCESIIDQP 464
Query: 347 VKSAAKTLDEEIREILGITDGLIRLSVGLEPLDELIEDIDNAL 389
+ E+ R+I GI D LIR S+G+E ++L D+ AL
Sbjct: 465 AIMSYWDSKEQ-RDIYGIKDNLIRFSIGVEDFEDLKNDLVQAL 506
>pdb|1CS1|A Chain A, Cystathionine Gamma-Synthase (Cgs) From Escherichia Coli
>gi|6137429|pdb|1CS1|B Chain B, Cystathionine
Gamma-Synthase (Cgs) From Escherichia Coli
>gi|6137430|pdb|1CS1|C Chain C, Cystathionine
Gamma-Synthase (Cgs) From Escherichia Coli
>gi|6137431|pdb|1CS1|D Chain D, Cystathionine
Gamma-Synthase (Cgs) From Escherichia Coli
Length = 386
Score = 207 bits (521), Expect = 2e-52
Identities = 127/359 (35%), Positives = 202/359 (55%), Gaps = 10/359 (2%)
Query: 33 PLYITAVFKQVGDAYPTDRGTELKYSREENPTVRKLEDKLAELEGSDNALAFNSGMSAIS 92
P+++++ + G P YSR NPT ++ LAELEG A+ N+GMSAI
Sbjct: 26 PIHLSSTYNFTGFNEPRAHD----YSRRGNPTRDVVQRALAELEGGAGAVLTNTGMSAIH 81
Query: 93 TLYFSLLEGGDKVVLSMEGYGTTIELAKLLRKFGVDVKLAYPSAD--SLIETIDEETKLV 150
+ L+ GD +V + YG + L L K G L D +L + E+ KLV
Sbjct: 82 LVTTVFLKPGDLLVAPHDCYGGSYRLFDSLAKRGCYRVLFVDQGDEQALRAALAEKPKLV 141
Query: 151 LVETMTNPTLKVIDVPEVAKRCREVGAILVVDNTFVTPLLYKPLEDGASYVVHSLTKYIA 210
LVE+ +NP L+V+D+ ++ REVGA+ VVDNTF++P L PL GA V+HS T Y+
Sbjct: 142 LVESPSNPLLRVVDIAKICHLAREVGAVSVVDNTFLSPALQNPLALGADLVLHSCTXYLN 201
Query: 211 GHNDVLGGAVL-WNGEFSRDLWEWRRRLGTIIQPFDAWMIERGMRTLEVRFERQSENAMA 269
GH+DV+ G V+ + + +L W +G FD++++ RG+RTL R E NA A
Sbjct: 202 GHSDVVAGVVIAKDPDVVTELAWWANNIGVTGGAFDSYLLLRGLRTLVPRMELAQRNAQA 261
Query: 270 IAEFLKDHPKVREVHYPGLKDDPYYKVARRLFKKDLYGGVVAFDLGSGDNAL-AFLRGLK 328
I ++L+ P V+++++P L ++ +++A R K +G +++F+L + L FL GL
Sbjct: 262 IVKYLQTQPLVKKLYHPSLPENQGHEIAARQQKG--FGAMLSFELDGDEQTLRRFLGGLS 319
Query: 329 RIFPSPSLGGVESIATYPVKSAAKTLDEEIREILGITDGLIRLSVGLEPLDELIEDIDN 387
+ SLGGVES+ ++ + E R GI++ L+R+S G+E ++LI D++N
Sbjct: 320 LFTLAESLGGVESLISHAATMTHAGMAPEARAAAGISETLLRISTGIEDGEDLIADLEN 378
>gb|AAF97598.1|AF286193_1 (AF286193) cystathionine-gamma-lyase [Acremonium chrysogenum]
Length = 423
Score = 206 bits (519), Expect = 3e-52
Identities = 123/351 (35%), Positives = 191/351 (54%), Gaps = 11/351 (3%)
Query: 37 TAVFKQVGDAYPTDRGTELKYSREENPTVRKLEDKLAELEGSDNALAFNSGMSAISTLYF 96
TAV K VG E +YSR NP E +A LE + ALAF+SG + +T+
Sbjct: 58 TAVGKPVG---------EYEYSRSANPNRTNFETAVAALEHARYALAFSSGSATTATILQ 108
Query: 97 SLLEGGDKVVLSMEGYGTTIELAKLLRKFGVDVKLAYPSADSLIETIDEETKLVLVETMT 156
SL G + +S GT ++ + GV V + E I ++T+L+ +ET +
Sbjct: 109 SLAAGSHVISVSDVYGGTHRYFTQVAKAHGVKVTFTPEIEVDVSEHITDQTRLIWIETPS 168
Query: 157 NPTLKVIDVPEVAKRCREVGAILVVDNTFVTPLLYKPLEDGASYVVHSLTKYIAGHNDVL 216
NPTL+++D+ V + G ++VVDNTF++P + PL+ GA VVHS+TKYI GH+DV+
Sbjct: 169 NPTLRLVDIRAVVSVAHKHGVLVVVDNTFLSPYVQNPLDLGADIVVHSVTKYINGHSDVV 228
Query: 217 GGAVLWNGEFSRD-LWEWRRRLGTIIQPFDAWMIERGMRTLEVRFERQSENAMAIAEFLK 275
G +N +D L + +G + FD+W+ RG++TL +R S NA A+A L+
Sbjct: 229 MGVAAFNSPELKDRLGFLQNAIGAVPSAFDSWLAHRGLKTLHLRAREASRNAAAVAAALE 288
Query: 276 DHPKVREVHYPGLKDDPYYKVARRLFKKDLYGGVVAFDLGSGDNALAFLRGLKRIFP-SP 334
P V V+YPGL P+ +A + + + GG+++F + G +A RIF +
Sbjct: 289 ASPNVISVNYPGLDSHPHRHIALKQHRDGMGGGMLSFRIRGGHDAAERFCQQTRIFTLAE 348
Query: 335 SLGGVESIATYPVKSAAKTLDEEIREILGITDGLIRLSVGLEPLDELIEDI 385
SLGGVES+ P + + RE +G+ D L+R+S G+E ++L D+
Sbjct: 349 SLGGVESLVELPSSMTHAGIPRDQREAVGVFDDLVRVSCGVEDAEDLKNDV 399
>pir||G81062 trans-sulfuration enzyme family protein NMB1609 [imported] -
Neisseria meningitidis (group B strain MD58)
>gi|7226859|gb|AAF41961.1| (AE002511) trans-sulfuration
enzyme family protein [Neisseria meningitidis MC58]
Length = 389
Score = 206 bits (518), Expect = 4e-52
Identities = 116/335 (34%), Positives = 195/335 (57%), Gaps = 4/335 (1%)
Query: 57 YSREENPTVRKLEDKLAELEGSDNALAFNSGMSAISTLYFSLLEGGDKVVLSMEGYGTTI 116
Y+R NPT E ++A LEG++ A+A ++GMSAI +F+ L+ GD V+ S +GTT+
Sbjct: 55 YTRTANPTTAAFEKRIAALEGAERAVATSAGMSAIQAAFFTFLQAGDHVISSRSLFGTTV 114
Query: 117 E-LAKLLRKFGVDVKLAYPS-ADSLIETIDEETKLVLVETMTNPTLKVIDVPEVAKRCRE 174
+ ++ KFG++V P+ + + TKL+ +ET +NP +V D+ +A+
Sbjct: 115 GFINNIVAKFGIEVSHVSPTDINEWKAAVKANTKLLFLETPSNPLGEVADLEALAELAHG 174
Query: 175 VGAILVVDNTFVTPLLYKPLEDGASYVVHSLTKYIAGHNDVLGGAVLWNGEFSRDLWEWR 234
+GA+LVVDN+ ++P+ +PL+ GA V S TK I GH V+GG + + E + +
Sbjct: 175 IGALLVVDNSLLSPVGSQPLKHGADISVSSATKAIDGHGRVMGGVLAGSEELLAQVAMYC 234
Query: 235 RRLGTIIQPFDAWMIERGMRTLEVRFERQSENAMAIAEFLKDHPKVREVHYPGLKDDPYY 294
G + PF+AW + G+ TL +R E+Q +NA+ IA++L+ P+V+ V+Y GL D P
Sbjct: 235 NSCGLAMSPFNAWQLLSGVETLSLRMEKQFDNALKIAQWLQAQPQVQAVYYTGLSDHPQA 294
Query: 295 KVARRLFKKDLYGGVVAFDLGSGDNALAFLRGLKRIFPSPSLGGVESIATYPVKSAAKTL 354
+ R+ +++ G V+ F++ + A + G++ + +LG V S T+P + +
Sbjct: 295 ALIRK--QQNGGGIVIGFEVADQEAAWKVVDGVELFSRTANLGDVRSTITHPWTTTHGRM 352
Query: 355 DEEIREILGITDGLIRLSVGLEPLDELIEDIDNAL 389
E + I GL+RLSVGLE + +LI+D+ AL
Sbjct: 353 QPEEKLAANIRPGLVRLSVGLEYVGDLIDDLKQAL 387
>pir||A82045 cystathionine gamma-synthase VC2683 [imported] - Vibrio cholerae
(group O1 strain N16961) >gi|9657278|gb|AAF95824.1|
(AE004334) cystathionine gamma-synthase [Vibrio
cholerae]
Length = 388
Score = 205 bits (517), Expect = 6e-52
Identities = 120/337 (35%), Positives = 191/337 (56%), Gaps = 8/337 (2%)
Query: 57 YSREENPTVRKLEDKLAELEGSDNALAFNSGMSAISTLYFSLLEGGDKVVLSMEGYGTTI 116
Y+R NP LE L ELE + A+ N G SAI+ +LL D +V + YG T
Sbjct: 47 YTRSGNPNRGLLEQTLYELECGEGAVVTNCGTSAINLWVTALLGPDDLIVAPHDCYGGTY 106
Query: 117 ELAKLLRKFGVDVKLAY---PSADSLIETIDEETKLVLVETMTNPTLKVIDVPEVAKRCR 173
L K G D K+ + +A +L + + + KL+L+ET +NP ++V+D+ + + +
Sbjct: 107 RLLNTRAKKG-DFKVQFVDQSNAAALTQALARKPKLLLIETPSNPLVRVVDIAHLCQLAK 165
Query: 174 EVGAILVVDNTFVTPLLYKPLEDGASYVVHSLTKYIAGHNDVLGGAVLW-NGEFSRDLWE 232
G ++ VDNTF+TP+ KPL GA +V+HS TKYI GH+DV+GG ++ + + + +L
Sbjct: 166 AQGTLVAVDNTFLTPVFQKPLTLGADFVLHSTTKYINGHSDVIGGVLICKHKQHAEELAW 225
Query: 233 WRRRLGTIIQPFDAWMIERGMRTLEVRFERQSENAMAIAEFLKDHPKVREVHYPGLKDDP 292
W LG+ PFD++M RG+RTL R E+A I +L+ V ++++P L D P
Sbjct: 226 WGNCLGSTGTPFDSYMTLRGIRTLGARMRVHEESAQQILAYLQTQSLVSKIYHPSLPDHP 285
Query: 293 YYKVARRLFKKDLYGGVVAFDLGSGDNALAFLRGLKRIFP-SPSLGGVESIATYPVKSAA 351
+++A++ ++ +G +++F+ L F G +F + SLGGVES+ +P
Sbjct: 286 GHEIAKK--QQSGFGAMLSFEFAGSFEQLKFFVGKLALFSLAESLGGVESLICHPASMTH 343
Query: 352 KTLDEEIREILGITDGLIRLSVGLEPLDELIEDIDNA 388
+ + EE GI+ L+RLSVGLE +LI D+D A
Sbjct: 344 RAMGEEALAEAGISQQLLRLSVGLEDASDLIADLDQA 380
>sp|P46807|METB_MYCLE CYSTATHIONINE GAMMA-SYNTHASE (CGS) (O-SUCCINYLHOMOSERINE
(THIOL)-LYASE) >gi|699273|gb|AAA63036.1| (U15183)
cystathionine gamma-synthase [Mycobacterium leprae]
Length = 388
Score = 205 bits (516), Expect = 8e-52
Identities = 133/361 (36%), Positives = 200/361 (54%), Gaps = 12/361 (3%)
Query: 33 PLYITAVFKQVGDAYPTDRGTELKYSREENPTVRKLEDKLAELEGSDNALAFNSGMSAIS 92
P+Y ++ F Q D RG +Y+R NP LE LA +E A AF+SGM+A
Sbjct: 35 PIYASSTFAQ--DGVGELRGG-FEYARTGNPMRAALEASLATVEEGVFARAFSSGMAASD 91
Query: 93 TLYFSLLEGGDKVVLSMEGYGTTIELA-KLLRKFGVD-VKLAYPSADSLIETIDEETKLV 150
+L GD V++ + YG T L K+ ++ VD + D++ I T+L+
Sbjct: 92 CALRVMLRPGDHVIIPDDVYGGTFRLIDKVFTQWNVDYTPVPLSDLDAVRAAITSRTRLI 151
Query: 151 LVETMTNPTLKVIDVPEVAKRCREVGAILVVDNTFVTPLLYKPLEDGASYVVHSLTKYIA 210
VET TNP L + D+ + + ++ ++VDNTF +P L +PL GA V+HS TKYI
Sbjct: 152 WVETPTNPLLSIADITSIGELGKKHSVKVLVDNTFASPALQQPLMLGADVVLHSTTKYIG 211
Query: 211 GHNDVLGGAVLWNG-EFSRDLWEWRRRLGTIIQPFDAWMIERGMRTLEVRFERQSENAMA 269
GH+DV+GGA++ N E + + G + PFDA++ RG++TL +R +R +ENA+
Sbjct: 212 GHSDVVGGALVTNDEELDQAFGFLQNGAGAVPSPFDAYLTMRGLKTLVLRMQRHNENAIT 271
Query: 270 IAEFLKDHPKVREVHYPGLKDDPYYKVARRLFKKDLYGGVVAFDLGSGDNALAFLRGLKR 329
+AEFL HP V V YPGL P ++VA R + +GG+V+ + +G A L +
Sbjct: 272 VAEFLAGHPSVSAVLYPGLPSHPGHEVAARQMRG--FGGMVSLRMRAGRLAAQDLCARTK 329
Query: 330 IFP-SPSLGGVESIATYPVKSAAKTLDEEIREILGITDGLIRLSVGLEPLDELIEDIDNA 388
+F + SLGGVES+ P +A T L + D L+RLSVG+E + +L+ D+ A
Sbjct: 330 VFTLAESLGGVESLIEQP---SAMTHASTTGSQLEVPDDLVRLSVGIEDVGDLLCDLKQA 386
Query: 389 L 389
L
Sbjct: 387 L 387
>sp|Q59829|CYSA_STRCO PUTATIVE CYSTATHIONINE GAMMA-LYASE (GAMMA-CYSTATHIONASE)
>gi|1017819|gb|AAC43615.1| (U37580) putative
cystathionine gamma-lyase [Streptomyces coelicolor]
Length = 392
Score = 205 bits (516), Expect = 8e-52
Identities = 131/347 (37%), Positives = 185/347 (52%), Gaps = 18/347 (5%)
Query: 48 PTDRGTELKYSREENPTVRKLEDKLAELEGSDNA----LAFNSGMSAISTLYFSLLEGGD 103
P D Y R+ENPT +LE + ELE A L F SGM+AIS++ FS L GD
Sbjct: 54 PGDPTGPYTYGRDENPTWTRLESAIGELEAPGEAGVETLVFASGMAAISSVLFSQLRAGD 113
Query: 104 KVVLSMEGYGTTIELAKLLRKFGVDVKLAYPSADSLIETIDEETKLVLVETMTNPTLKVI 163
VL +GY + L +G++V+ A D+ ++ +D KL+ +ET +NP L V
Sbjct: 114 TAVLRDDGYQALPLVRAQLEAYGIEVRTAPTGRDAQLDVLDG-AKLLWIETPSNPGLDVC 172
Query: 164 DVPEVAKRCREVGAILVVDNTFVTPLLYKPLEDGASYVVHSLTKYIAGHNDVLGGAVLWN 223
DV + + GA++ VDNT TPL +PLE GA + V S TK + GH DVL G V
Sbjct: 173 DVRRLVEAAHAGGALVAVDNTLATPLGQRPLELGADFSVASGTKQLTGHGDVLLGYVAGR 232
Query: 224 GEFSRD-LWEWRRRLGTIIQPFDAWMIERGMRTLEVRFERQSENAMAIAEFLKDHPKVRE 282
+ + WR+ +G I P +AW+ R + TL++R +RQ A+ +AE L+ P++
Sbjct: 233 DAGAMAAVRRWRKIVGAIPGPMEAWLAHRSIATLQLRVDRQDSTALKVAEALRTRPEITG 292
Query: 283 VHYPGLKDDPYYKVARRLFKKDLYGGVVAFDLGSGDNALAFLRGLKRIFPSPSLGGVESI 342
+ YPGL DDP +KVA + + YG VV+F L S A FL L+ + + S GGV S
Sbjct: 293 LRYPGLPDDPSHKVASQQMLR--YGCVVSFTLPSRARADRFLDALRLVEGATSFGGVRST 350
Query: 343 ATYPVKSAAKTLDEEIREILGITDGLIRLSVGLEPLDELIEDIDNAL 389
A + + E G IRLSVG E D+L+ D+ AL
Sbjct: 351 AERRGRWGGDAVPE----------GFIRLSVGAEDPDDLVADLVRAL 387
>pir||E81806 O-succinylhomoserine sulfhydrolase (EC 4.2.99.-) NMA1808 [imported]
- Neisseria meningitidis (group A strain Z2491)
>gi|7380447|emb|CAB85033.1| (AL162757)
O-succinylhomoserine sulfhydrolase [Neisseria
meningitidis Z2491]
Length = 389
Score = 205 bits (516), Expect = 8e-52
Identities = 116/335 (34%), Positives = 195/335 (57%), Gaps = 4/335 (1%)
Query: 57 YSREENPTVRKLEDKLAELEGSDNALAFNSGMSAISTLYFSLLEGGDKVVLSMEGYGTTI 116
Y+R NPT E ++A LEG++ A+A ++GMSAI +F+ L+ GD V+ S +GTT+
Sbjct: 55 YTRTANPTTAAFEKRIAALEGAERAVATSTGMSAIQAAFFTFLQAGDHVISSRSLFGTTV 114
Query: 117 E-LAKLLRKFGVDVKLAYPS-ADSLIETIDEETKLVLVETMTNPTLKVIDVPEVAKRCRE 174
+ ++ KFG++V P+ + + TKL+ +ET +NP +V D+ +A+
Sbjct: 115 GFINNIVTKFGIEVSHVSPTDINEWKAAVKANTKLLFLETPSNPLGEVADLEALAELAHG 174
Query: 175 VGAILVVDNTFVTPLLYKPLEDGASYVVHSLTKYIAGHNDVLGGAVLWNGEFSRDLWEWR 234
+GA+LVVDN+ ++P+ +PL+ GA V S TK I GH V+GG + + E + +
Sbjct: 175 IGALLVVDNSLLSPVGSQPLKHGADISVSSATKAIDGHGRVMGGVLAGSEELMAQVAVYC 234
Query: 235 RRLGTIIQPFDAWMIERGMRTLEVRFERQSENAMAIAEFLKDHPKVREVHYPGLKDDPYY 294
G + PF+AW + G+ TL +R E+Q +NA+ IA++L+ P+V+ V+Y GL D P
Sbjct: 235 NSCGLAMSPFNAWQLLSGVETLSLRMEKQFDNALKIAQWLQAQPQVQAVYYTGLPDHPQA 294
Query: 295 KVARRLFKKDLYGGVVAFDLGSGDNALAFLRGLKRIFPSPSLGGVESIATYPVKSAAKTL 354
++ R+ +++ G V+ F++ A + G++ + +LG V S T+P + +
Sbjct: 295 ELIRK--QQNGGGIVIGFEVADQAAAWKVVDGVELFSRTANLGDVRSTITHPWTTTHGRM 352
Query: 355 DEEIREILGITDGLIRLSVGLEPLDELIEDIDNAL 389
E + I GL+RLSVGLE + +LI+D+ AL
Sbjct: 353 QPEEKLAANIRPGLVRLSVGLEYVGDLIDDLKQAL 387
>pir||T37173 probable cystathionine/methionine gamma-synthase/lyase -
Streptomyces coelicolor >gi|5457270|emb|CAB46958.1|
(AL096823) putative cystathionine/methionine
gamma-synthase/lyase [Streptomyces coelicolor A3(2)]
Length = 392
Score = 205 bits (515), Expect = 1e-51
Identities = 131/347 (37%), Positives = 185/347 (52%), Gaps = 18/347 (5%)
Query: 48 PTDRGTELKYSREENPTVRKLEDKLAELEGSDNA----LAFNSGMSAISTLYFSLLEGGD 103
P D Y R+ENPT +LE + ELE A L F SGM+AIS++ FS L GD
Sbjct: 54 PGDPTGPYTYGRDENPTWTRLESAIGELEAPGEAGVETLVFASGMAAISSVLFSQLRAGD 113
Query: 104 KVVLSMEGYGTTIELAKLLRKFGVDVKLAYPSADSLIETIDEETKLVLVETMTNPTLKVI 163
VL +GY + L +G++V+ A D+ ++ +D KL+ +ET +NP L V
Sbjct: 114 TAVLPDDGYQALPLVRAQLEAYGIEVRTAPTGRDAQLDVLDG-AKLLWIETPSNPGLDVC 172
Query: 164 DVPEVAKRCREVGAILVVDNTFVTPLLYKPLEDGASYVVHSLTKYIAGHNDVLGGAVLWN 223
DV + + GA++ VDNT TPL +PLE GA + V S TK + GH DVL G V
Sbjct: 173 DVRRLVEAAHAGGALVAVDNTLATPLGQRPLELGADFSVASGTKQLTGHGDVLLGYVAGR 232
Query: 224 GEFSRD-LWEWRRRLGTIIQPFDAWMIERGMRTLEVRFERQSENAMAIAEFLKDHPKVRE 282
+ + WR+ +G I P +AW+ R + TL++R +RQ A+ +AE L+ P++
Sbjct: 233 DAGAMAAVRRWRKIVGAIPGPMEAWLAHRSIATLQLRVDRQDSTALKVAEALRTRPEITG 292
Query: 283 VHYPGLKDDPYYKVARRLFKKDLYGGVVAFDLGSGDNALAFLRGLKRIFPSPSLGGVESI 342
+ YPGL DDP +KVA + + YG VV+F L S A FL L+ + + S GGV S
Sbjct: 293 LRYPGLPDDPSHKVASQQMLR--YGCVVSFTLPSRARADRFLDALRLVEGATSFGGVRST 350
Query: 343 ATYPVKSAAKTLDEEIREILGITDGLIRLSVGLEPLDELIEDIDNAL 389
A + + E G IRLSVG E D+L+ D+ AL
Sbjct: 351 AERRGRWGGDAVPE----------GFIRLSVGAEDPDDLVADLLRAL 387
>emb|CAC11228.1| (AL445063) cystathionine gamma-lyase related protein [Thermoplasma
acidophilum]
Length = 384
Score = 204 bits (513), Expect = 2e-51
Identities = 132/377 (35%), Positives = 208/377 (55%), Gaps = 28/377 (7%)
Query: 30 LHDPLY---ITAVFKQVGDAYP-------TD--RGTELKYSREENPTVRKLEDKLAELEG 77
L DP + T +F+ YP TD R Y+R NPTV+ E+K A +EG
Sbjct: 19 LRDPRFGNVTTPIFETSTFVYPNPEKEAYTDHTRDQPYIYTRWGNPTVQAFEEKYAAVEG 78
Query: 78 SDNALAFNSGMSAISTLYFSLLEGGDKVVLSMEGYGTTIELA-KLLRKFGVDVKLAYPSA 136
++ AL+F+SGM AI++ LL G +++ + YG T K+L G+ V
Sbjct: 79 AEYALSFSSGMGAITSAITGLLHPGSRMLSLSDLYGQTFYFFNKVLGDLGIKVDYIDTER 138
Query: 137 DSLIETIDEETKLVLVETMTNPTLKVIDVPEVAKRCREVGAILVVDNTFVTPLLYKPLED 196
+ ++ + + +E++TNPTLKV D+ V+ ++ ++++VD TF +P PL+
Sbjct: 139 INSLDFDPSKYDAIYMESITNPTLKVPDIRSVSDYAKK--SLVIVDATFASPYNQHPLDL 196
Query: 197 GASYVVHSLTKYIAGHNDVLGGAVLWNG-EFSRDLWEWRRRLGTIIQPFDAWMIERGMRT 255
GA V+HS TKYI GH+D++ G V N E L R+ G+ P A++ RG++T
Sbjct: 197 GADVVIHSATKYIGGHSDIVMGVVGTNSKEIFNSLVIRRKTYGSNPDPIQAYLALRGLKT 256
Query: 256 LEVRFERQSENAMAIAEFLKDHPKVREVHYPGLKDDPYYKVARRLFKKDL--YGGVVAFD 313
L +R E+ + N M IA FL+ + + V+YP + + KK L +GG+V+F+
Sbjct: 257 LGLRMEKHNRNGMEIATFLRKNDSISRVYYPDTE----------MGKKVLSGFGGMVSFE 306
Query: 314 LGSGDNALAFLRGLKRIFPSPSLGGVESIATYPVKSAAKTLDEEIREILGITDGLIRLSV 373
+ + +FLR L + SLGGVES+ T P +++ +L E RE +GI+D L+R S+
Sbjct: 307 IRRDRDVHSFLRKLSIPMVAASLGGVESLITLPAETSHSSLSREERERMGISDNLVRFSI 366
Query: 374 GLEPLDELIEDIDNALG 390
G+E ++LI DI NALG
Sbjct: 367 GIEDAEDLIADIQNALG 383
>pir||T19213 hypothetical protein C12C8.2 - Caenorhabditis elegans
>gi|3874270|emb|CAB03873.1| (Z81467) predicted using
Genefinder~Similaritry to Pseudomonas
l-methionine-alpha-deamino-gamma-mercaptomethane lyase
(TR:Q52103), contains similarity to Pfam domain: PF01053
(Cys/Met metabolism PLP-dependent enzyme), Score=673.4,
E-value=3.6e-199, N=1>
Length = 444
Score = 203 bits (510), Expect = 4e-51
Identities = 133/400 (33%), Positives = 219/400 (54%), Gaps = 36/400 (9%)
Query: 11 EKDINLPWDQREGEIKMKPLHD------PLYITAV--FKQVGDAYPTDRGTELKYSREEN 62
EK +L D R KPL + P+Y ++ FK V + G Y R N
Sbjct: 57 EKFESLHLDSRISTSHAKPLSNADPVVVPIYHSSTYRFKTVDQFNEDNHGANFVYRRCGN 116
Query: 63 PTVRKLEDKLAELEGSDNALAFNSGMSAISTLYFSLLEGGDKVVLSMEGY-GTTIELAKL 121
PT +E + E+EG +L +NSG++AIS ++ L G +++ Y GT+ + +
Sbjct: 117 PTTENVEVVINEIEGGAGSLLYNSGLAAISAVFLEFLSSGAHMIVMNPIYSGTSSFINET 176
Query: 122 LRKFGV-----DVKLAYPSADSLIETIDEETKLVLVETMTNPTLKVIDVPEVAKRCREVG 176
L +FGV DV+ A ++ + I TK++ E++ NPT+ V D+ + ++
Sbjct: 177 LARFGVEITSVDVEKEKDFAGAVEKAIRPNTKMIYFESIANPTMAVPDILGTIEVAKKYK 236
Query: 177 AILVVDNTFVTPLLYKPLEDGASYVVHSLTKYIAGHNDVLGGAVLWNGEFSRDLWEWRR- 235
+ +D TF +P +PL+ GA +HS +KYI GH DV+ G V + S D W+ +
Sbjct: 237 ILTCLDATFSSPYNIQPLKLGADISLHSCSKYIGGHTDVIAGVVTVS---SYDNWKKLKL 293
Query: 236 ---RLGTIIQPFDAWMIERGMRTLEVRFERQSENAMAIAEFLKDHPKVREVHYPGLKDDP 292
G+ + P+DA ++ RG++TL +R +R SENA AEFL+ HPKV V YPGL P
Sbjct: 294 QQLTTGSSLSPYDAALLTRGLKTLGLRVDRISENAQKTAEFLESHPKVERVFYPGLPSHP 353
Query: 293 YYKVARRLFKKDLYGGVVAFDLGSGDNALAFLRGLKRIFPSPSLGGVESIATYPVK-SAA 351
++ A+++ K+ + G++AFD+G+ +NA+ + + SLGG ES+ +P+ S
Sbjct: 354 QHQYAKQVMKQ--FAGMIAFDVGTAENAIKLVEAI-------SLGGTESLIEHPLSMSHG 404
Query: 352 KTLDEEIREILG--ITDGLIRLSVGLEPLDELIEDIDNAL 389
K L +R + G + GL+R SVG+E ++++I D+++AL
Sbjct: 405 KHL---LRYLDGPTVAPGLLRFSVGIENVEDIIGDLNDAL 441
>gb|AAD34548.1|AF141602_1 (AF141602) cystathionine-gamma-synthase precursor [Glycine max]
Length = 536
Score = 202 bits (508), Expect = 7e-51
Identities = 121/359 (33%), Positives = 196/359 (53%), Gaps = 8/359 (2%)
Query: 40 FKQVGDA--YPTDRGTELKYSREENPTVRKLEDKLAELEGSDNALAFNSGMSAISTLYFS 97
FK+ D + +R +Y R NPT LE+K++ LEG+++ + SGM A L+ +
Sbjct: 180 FKKTADLIDFKENRQVSYEYGRYGNPTTVVLEEKISALEGAESTVIMASGMCASVVLFMA 239
Query: 98 LLEGGDKVVLSMEGYGTT-IELAKLLRKFGVDVKLAYPSADSLIETIDEE--TKLVLVET 154
L+ G +V + + Y T I + L K G+ + P+ +E+ E+ L E+
Sbjct: 240 LVPAGGHLVTTTDCYRKTRIFIETFLPKMGITTTVIDPADVGALESALEQHNVSLFFTES 299
Query: 155 MTNPTLKVIDVPEVAKRCREVGAILVVDNTFVTPLLYKPLEDGASYVVHSLTKYIAGHND 214
TNP L+ +D+ V++ C + G +L +D TF TPL K L GA ++HSLTKY+ GH+D
Sbjct: 300 PTNPFLRCVDIKLVSELCHKKGTLLCIDGTFATPLNQKALALGADLILHSLTKYMGGHHD 359
Query: 215 VLGGAVLWNGEFSRDLWEWRRRLGTIIQPFDAWMIERGMRTLEVRFERQSENAMAIAEFL 274
VLGG + + + + LG + P A++ RGM+TL +R ++Q+ M +A+ L
Sbjct: 360 VLGGCISGSIKVVSQIRTLHHVLGGTLNPNAAYLFIRGMKTLHLRVQQQNSTGMRMAKLL 419
Query: 275 KDHPKVREVHYPGLKDDPYYKVARRLFKKDLYGGVVAFDL-GSGDNALAFLRGLKRIFPS 333
+ HPKV+ V+YPGL P +++A+R + +GGVV+F++ G + F+ LK + +
Sbjct: 420 EAHPKVKRVYYPGLPSHPEHELAKR--QMTGFGGVVSFEIDGDLHTTIKFIDSLKIPYIA 477
Query: 334 PSLGGVESIATYPVKSAAKTLDEEIREILGITDGLIRLSVGLEPLDELIEDIDNALGVV 392
S GG ESI P + L + R I D L+R S G+E ++L D+ AL +
Sbjct: 478 ASFGGCESIVDQPAILSYWDLPQSERAKYKIYDNLVRFSFGVEDFEDLKADVLQALEAI 536
>pir||E72274 cystathionine gamma-synthase - Thermotoga maritima (strain MSB8)
>gi|4981827|gb|AAD36345.1|AE001782_6 (AE001782)
cystathionine gamma-synthase [Thermotoga maritima]
Length = 379
Score = 200 bits (504), Expect = 2e-50
Identities = 128/377 (33%), Positives = 204/377 (53%), Gaps = 21/377 (5%)
Query: 22 EGEIKMKPLHDPLYITA-----VFKQVGDAYPTDRGTELKYSREENPTVRKLEDKLAELE 76
E +I +K L P++ T F ++ A + E Y R NPT R +E KLA LE
Sbjct: 12 EEDIPLKALSFPIFETTNFYFDSFDEMSKAL-RNGDYEFVYKRGSNPTTRLVEKKLAALE 70
Query: 77 GSDNALAFNSGMSAISTLYFSLLEGGDKVVLSMEGYGTTIELAKLL-RKFGVDVKLAYPS 135
++A SGMSAIS L GD VV E Y + L +KF ++V P
Sbjct: 71 ECEDARLVASGMSAISLSILHFLSSGDHVVCVDEAYSWAKKFFNYLSKKFDIEVSYVPPD 130
Query: 136 ADSLIETIDEETKLVLVETMTNPTLKVIDVPEVAKRCREVGAILVVDNTFVTPLLYKPLE 195
A+ ++E I ++TKL+ +E+ T+ +KVID+ +V + E+ V+DNT+ +P+ KP
Sbjct: 131 AERIVEAITKKTKLIYLESPTSMRMKVIDIRKVTEAAGELKIKTVIDNTWASPIFQKPKL 190
Query: 196 DGASYVVHSLTKYIAGHNDVLGGAVLWNGEFSRDLW-EWRRRLGTIIQPFDAWMIERGMR 254
G VVHS TKYI+GH DV+ G + + E ++++ + + +G ++ P +AW+I RG+R
Sbjct: 191 LGVDVVVHSATKYISGHGDVMAGVIAGDVEDMKNIFVDEYKNIGPVLSPIEAWLILRGLR 250
Query: 255 TLEVRFERQSENAMAIAEFLKDHPKVREVHYPGLKDDPYYKVARRLFKKDLYGGVVAFDL 314
TLE+R ++ ENA+ +++FL DHPKV EV+YP P Y++A G+++F L
Sbjct: 251 TLELRMKKHYENALVVSDFLMDHPKVLEVNYPMNPRSPQYELASSQMSGG--SGLMSFRL 308
Query: 315 --GSGDNALAFLRGLKRIFPSPSLGGVESIATYPVKSAAKTLDEEIREILGITDGLIRLS 372
S + F+ L+ + S G E++ P + +++ LIR+
Sbjct: 309 KTDSAEKVKEFVESLRVFRMAVSWGSHENLVV-PRVAYGDCPKKDV--------NLIRIH 359
Query: 373 VGLEPLDELIEDIDNAL 389
VGL ++L+ED+D AL
Sbjct: 360 VGLGDPEKLVEDLDQAL 376
>gb|AAF69585.1|AC019154_4 (AC019154) Cystathionine Gamma Synthase [Leishmania major]
Length = 409
Score = 199 bits (500), Expect = 6e-50
Identities = 126/365 (34%), Positives = 196/365 (53%), Gaps = 13/365 (3%)
Query: 33 PLYITAVFKQVGDAYPTDRGTELKYSREENPTVRKLEDKLAELEGSDNALAFNSGMSAIS 92
P+Y + F Q ++ + + Y+R NPTV LE KL LE +N+GM+A +
Sbjct: 46 PIYQSTTFVQ--ESINSYQAKGYSYTRSANPTVAVLEQKLCALENGSYCTVYNTGMAATT 103
Query: 93 TLYFSLLEGGDKVVLSMEGYGTTIELAKLL-RKFGVDVKLA-YPSADSLIETIDEETKLV 150
T S + GD +L+ YG T ++ + G++ ++I++I TKLV
Sbjct: 104 TAISSFMNAGDHAILTNCCYGGTNRACRVFFSRLGMEFTFVDMRDPQNVIDSIKPNTKLV 163
Query: 151 LVETMTNPTLKVIDVPEVAKRCREVGAILVVDNTFVTPLLYKPLEDGASYVVHSLTKYIA 210
+ ET NPTL +IDV V+K C+E G + + DNTF T + +PL+ GA + S TKY+
Sbjct: 164 ISETPANPTLILIDVAAVSKICKERGIVHMCDNTFATAYIMRPLDHGADVTLISTTKYVD 223
Query: 211 GHNDVLGGAVLWNG-EFSRDLWEWRRRLGTIIQPFDAWMIERGMRTLEVRFERQSENAMA 269
GH+ +GGA++ N E + + LG ++ P A++ + ++T+ +R +QS NA
Sbjct: 224 GHDMTVGGALVTNSKELDAKVRLTQNILGNVMSPQVAFLQLQTVKTMSLRVTKQSHNAQK 283
Query: 270 IAEFLKDHPKVREVHYPGLKDDPYYKVARRLFKKDLYGGVVAFDLGSGDNALAFLRGLKR 329
IAEFL+ H V V YPGL P ++A R + +L+GG++ F++ G A R L
Sbjct: 284 IAEFLETHRAVDRVVYPGLASHPQKELADRQHRNNLHGGMLWFEVKGG---TAAGRRLMD 340
Query: 330 IFPSP-----SLGGVESIATYPVKSAAKTLDEEIREILGITDGLIRLSVGLEPLDELIED 384
P P +LG ESI T P + E R +GITDG +R+S G+E +D+LI
Sbjct: 341 TVPRPWSLCENLGASESIITCPSVMTHANMTSEDRMKVGITDGFVRVSCGIEDVDDLIAA 400
Query: 385 IDNAL 389
+ A+
Sbjct: 401 LKVAM 405
>gb|AAB03241.1| (U28383) cystathionine beta-lyase [Aspergillus nidulans]
Length = 439
Score = 198 bits (498), Expect = 1e-49
Identities = 126/362 (34%), Positives = 201/362 (54%), Gaps = 23/362 (6%)
Query: 33 PLYITAVFKQVGDAYPTDRGTELKYSREENPTVRKLEDKLAELEGSDNALAFNSGMSAIS 92
P+Y +A FKQ + G E Y+R NPT LE LA++ + AL +SGM+A+
Sbjct: 57 PIYQSATFKQSSH----EGGGEYDYTRSGNPTRTHLERHLAKIMSTQRALVVSSGMAALD 112
Query: 93 TLYFSLLEGGDKVVLSMEGYGTTIELAKLLRKFGVDV--KLAYPSADSLIETIDEETKLV 150
+ LL GD+VV + YG T L K L G + + + D + E + ++T +V
Sbjct: 113 VIT-RLLRPGDEVVTGDDLYGGTNRLLKYLSTNGGIIVHHVDTTNPDKVKEVLTDKTAMV 171
Query: 151 LVETMTNPTLKVIDVPEVAKRCREVG--AILVVDNTFVTPLLYKPLEDGASYVVHSLTKY 208
L+ET TNP +K++D+P +A E +++VDNT ++PLL PLE GA V S TKY
Sbjct: 172 LLETPTNPLIKIVDIPTIAAASHEANPNCLVIVDNTMMSPLLLSPLELGADVVYESGTKY 231
Query: 209 IAGHNDVLGGAVLWNG-EFSRDLWEWRRRLGTIIQPFDAWMIERGMRTLEVRFERQSENA 267
++GH+DV+ G + N L+ G + PFD+W++ RG++TL+VR ++Q NA
Sbjct: 232 LSGHHDVMAGVIAVNDPALGERLYFPINASGCGLSPFDSWLLMRGVKTLKVRMDQQQANA 291
Query: 268 MAIAEFLKDHPKVREVHYPGLKDDPYYKVARRLFKKDLYGGVVAFDLGSGDNALAFLR-- 325
IAEFL+ H +V YPGL+ P Y++ + + G V++F+ G + +
Sbjct: 292 QRIAEFLESHG--FKVRYPGLRSHPQYELHHSMARG--AGAVLSFETGDVSVSERIVANA 347
Query: 326 --GLKRIFPSPSLGGVESIATYPVKSAAKTLDEEIREILGITDGLIRLSVGLEPLDELIE 383
G +R F G V ++ + P + + ++D E R+ + + LIRL VG+E +D+LI+
Sbjct: 348 SVGYQRYF-----GCVNTLISLPCRMSHASIDAETRKERAMPEDLIRLCVGIEDVDDLID 402
Query: 384 DI 385
D+
Sbjct: 403 DL 404
>emb|CAA37547.1| (X53460) cystathionine gamma-lyase. [Rattus norvegicus]
Length = 364
Score = 196 bits (492), Expect = 5e-49
Identities = 127/338 (37%), Positives = 194/338 (56%), Gaps = 8/338 (2%)
Query: 57 YSREENPTVRKLEDKLAELEGSDNALAFNSGMSAISTLYFSLLEGGDKVVLSMEGYGTTI 116
YSR NPT LE +A L+G+ + L F G++A +T+ LL+ GD+V+ E YG T
Sbjct: 25 YSRSGNPTRNCLEKAVAALDGAKHCLTFARGLAATTTITH-LLKAGDEVICMDEVYGGTN 83
Query: 117 E-LAKLLRKFGVDVKLAYPSADSLIET-IDEETKLVLVETMTNPTLKVIDVPEVAKRC-R 173
++ +FG+ + S L+E I +TKLV +ET TNPTLK+ D+ A+ +
Sbjct: 84 RYFRRVASEFGLKISFVDCSKTKLLEAAITPQTKLVWIETPTNPTLKLADIKACAQIVHK 143
Query: 174 EVGAILVVDNTFVTPLLYKPLEDGASYVVHSLTKYIAGHNDVLGGAVLWNGE-FSRDLWE 232
ILVVDNTF++ +PL GA + S TKY+ GH+DV+ G V N + + L
Sbjct: 144 HKDIILVVDNTFMSAYFQRPLALGADICMCSATKYMNGHSDVVMGLVSVNSDDLNERLRF 203
Query: 233 WRRRLGTIIQPFDAWMIERGMRTLEVRFERQSENAMAIAEFLKDHPKVREVHYPGLKDDP 292
+ LG + PFD ++ RG++ + ++ MA+A FL+ +P+V +V YPGL P
Sbjct: 204 LQNSLGAVPSPFDCYLCCRGLKHCRSGWRNTFQDGMAVARFLESNPRVEKVIYPGLPSHP 263
Query: 293 YYKVARRLFKKDLYGGVVAFDL-GSGDNALAFLRGLKRIFPSPSLGGVESIATYPVKSAA 351
+++A+R + G+V+F + G+ +A FL+ +K + SLGG ES+A P
Sbjct: 264 QHELAKRSARA--CPGMVSFYIKGTLQHAQVFLKNIKLFALAESLGGYESLAELPAIMTH 321
Query: 352 KTLDEEIREILGITDGLIRLSVGLEPLDELIEDIDNAL 389
++ E+ R LGI+D LIRLSVGLE +L+ED+ AL
Sbjct: 322 ASVPEKDRATLGISDTLIRLSVGLEDEKDLLEDLGQAL 359
>pir||F70632 probable metZ protein - Mycobacterium tuberculosis (strain H37RV)
>gi|1817706|emb|CAB06597.1| (Z84725) metZ [Mycobacterium
tuberculosis]
Length = 406
Score = 195 bits (490), Expect = 9e-49
Identities = 122/343 (35%), Positives = 188/343 (54%), Gaps = 14/343 (4%)
Query: 57 YSREENPTVRKLEDKLAELEGSDNALAFNSGMSAISTLYFSLLEGGDKVVLSMEGYGTT- 115
YSR NPTV E++L +EG+ A A SGM+A+ T +LL GD++V + +G+
Sbjct: 67 YSRYGNPTVSVFEERLRLIEGAPAAFATASGMAAVFTSLGALLGAGDRLVAARSLFGSCF 126
Query: 116 IELAKLLRKFGVDVKLAYPSADSLIE---TIDEETKLVLVETMTNPTLKVIDVPEVAKRC 172
+ +++L ++GV + D L + + T+ V ET +NP ++D+ V +
Sbjct: 127 VVCSEILPRWGVQT--VFVDGDDLSQWERALSVPTQAVFFETPSNPMQSLVDIAAVTELA 184
Query: 173 REVGAILVVDNTFVTPLLYKPLEDGASYVVHSLTKYIAGHNDVLGGAVLWNGEF-SRDLW 231
GA +V+DN F TPLL + G VV+S TK+I G VLGGA+L + E+ +
Sbjct: 185 HAAGAKVVLDNVFATPLLQQGFPLGVDVVVYSGTKHIDGQGRVLGGAILGDREYIDGPVQ 244
Query: 232 EWRRRLGTIIQPFDAWMIERGMRTLEVRFERQSENAMAIAEFLKDHPKVREVHYPGLKDD 291
+ R G + F+AW++ +G+ TL +R + + +A IAEFL HP VR V YP L
Sbjct: 245 KLMRHTGPAMSAFNAWVLLKGLETLAIRVQHSNASAQRIAEFLNGHPSVRWVRYPYLPSH 304
Query: 292 PYYKVARRLFKKDLYGGVVAFDLGSGDN-----ALAFLRGLKRIFPSPSLGGVESIATYP 346
P Y +A+R G VV F L ++ A L ++ I S +LG +S+ T+P
Sbjct: 305 PQYDLAKRQMSGG--GTVVTFALDCPEDVAKQRAFEVLDKMRLIDISNNLGDAKSLVTHP 362
Query: 347 VKSAAKTLDEEIREILGITDGLIRLSVGLEPLDELIEDIDNAL 389
+ + + E R +G+ DG++R+SVGLE D+LI DID AL
Sbjct: 363 ATTTHRAMGPEGRAAIGLGDGVVRISVGLEDTDDLIADIDRAL 405
>pir||C81271 probable O-acetylhomoserine (thiol)-lyase (EC 4.2.99.10) Cj1727c
[imported] - Campylobacter jejuni (strain NCTC 11168)
>gi|6969142|emb|CAB73713.1| (AL139079) putative
O-acetylhomoserine (thiol)-lyase [Campylobacter jejuni]
Length = 423
Score = 192 bits (482), Expect = 7e-48
Identities = 111/369 (30%), Positives = 185/369 (50%), Gaps = 36/369 (9%)
Query: 57 YSREENPTVRKLEDKLAELEGSDNALAFNSGMSAISTLYFSLLEGGDKVVLSMEGYGTTI 116
YSR NPT L +LA +EG + SGM+A +L GD V S + YG T
Sbjct: 53 YSRLSNPTSDVLGQRLANVEGGAFGIPVASGMAACFYALINLASSGDNVAYSNKIYGGTQ 112
Query: 117 EL-AKLLRKFGVDVK-LAYPSADSLIETIDEETKLVLVETMTNPTLKVIDVPEVAKRCRE 174
L + L+ FG++ + DSL + ID+ TK + E+++NP + + D+ ++ + ++
Sbjct: 113 TLISHTLKNFGIEAREFDIDDLDSLEKVIDQNTKAIFFESLSNPQIAIADIEKINQIAKK 172
Query: 175 VGAILVVDNTFVTPLLYKPLEDGASYVVHSLTKYIAGHNDVLGGAVLWNGEFS------- 227
+ + DNT TP L +P + G +VHSL+KY++G LGGA++ + +
Sbjct: 173 HKIVSICDNTVATPFLLQPFKHGVDVIVHSLSKYVSGQGTALGGALIERKDLNDLLKNND 232
Query: 228 ---------------------------RDLWEWRRRLGTIIQPFDAWMIERGMRTLEVRF 260
R + W R LG + P +AW++ +G+ TL VR
Sbjct: 233 RYKAFNTPDPSYHGLNLNTLDLPIFSIRVIITWLRDLGASLAPQNAWLLLQGLETLAVRI 292
Query: 261 ERQSENAMAIAEFLKDHPKVREVHYPGLKDDPYYKVARRLFKKDLYGGVVAFDLGSGDNA 320
E+ S+NA +A FL HP ++ V+YP L + Y+ + ++ F K+ G+++F+ ++A
Sbjct: 293 EKHSQNAEKVANFLNSHPDIKGVNYPTLASNAYHNLFKKYFDKNFASGLLSFEAKDYEHA 352
Query: 321 LAFLRGLKRIFPSPSLGGVESIATYPVKSAAKTLDEEIREILGITDGLIRLSVGLEPLDE 380
+ + +LG +S+ +P + L EE + GIT IRLS+GLE D+
Sbjct: 353 RRICDKTQLFLLAANLGDSKSLIIHPASTTHSQLSEEELQKAGITKATIRLSIGLENSDD 412
Query: 381 LIEDIDNAL 389
LI D+ A+
Sbjct: 413 LIADLKQAI 421
>pir||G75463 O-acetylhomoserine (thiol)-lyase - Deinococcus radiodurans (strain
R1) >gi|6458592|gb|AAF10450.1|AE001941_3 (AE001941)
O-acetylhomoserine (thiol)-lyase [Deinococcus
radiodurans]
Length = 573
Score = 191 bits (481), Expect = 1e-47
Identities = 125/378 (33%), Positives = 188/378 (49%), Gaps = 46/378 (12%)
Query: 57 YSREENPTVRKLEDKLAELEGSDNALAFNSGMSAISTLYFSLLEGGDKVVLSMEGYGTTI 116
YSR NPT E ++A LEG AL+ +SG + +L + GD +V S YG T+
Sbjct: 190 YSRIMNPTNDVFEQRVAALEGGVGALSVSSGHAGQLVTLLTLAQAGDNIVSSPNLYGGTV 249
Query: 117 ELAKL-LRKFGVDVKLAYPSA--DSLIETIDEETKLVLVETMTNPTLKVIDVPEVAKRCR 173
++ L++ G++V+ + IDE T+ V +ET+ NP L + D VAK
Sbjct: 250 NQFRVTLKRLGIEVRFTSKDERPEEFAALIDERTRAVYLETIGNPALNIPDFEGVAKVAH 309
Query: 174 EVGAILVVDNTFVTPLLY-KPLEDGASYVVHSLTKYIAGHNDVLGGAVLWNGEF------ 226
E G +VVDNTF Y +PL GA+ V+HS +K+I GH + +GG ++ G F
Sbjct: 310 EHGVAVVVDNTFGAGGYYCQPLRHGANIVLHSASKWIGGHGNGIGGVIVDGGNFDWGSGR 369
Query: 227 ----------------------------------SRDLWEWRRRLGTIIQPFDAWMIERG 252
+R E R LGT + P AW +G
Sbjct: 370 YPLMTEPSPSYHGLKFWETFGEGNGLGLPNIAFITRARTEGLRDLGTTLAPQQAWQFLQG 429
Query: 253 MRTLEVRFERQSENAMAIAEFLKDHPKVREVHYPGLKDDPYYKVARRLFKKDLYGGVVAF 312
+ TL +R ER +EN +A+A +L HP V++V YPGL + P+Y A+ + G V+ F
Sbjct: 430 LETLSLRAERHAENTLALAHWLISHPDVKQVTYPGLSNHPHYDRAQTYLPRGA-GAVLTF 488
Query: 313 DLGSGDNA-LAFLRGLKRIFPSPSLGGVESIATYPVKSAAKTLDEEIREILGITDGLIRL 371
+L G A AF+R +K ++G ++ +P + LDE + G+T GLIR+
Sbjct: 489 ELRGGRAAGEAFIRSVKLAQHVANVGDTRTLVIHPASTTHSQLDEVTQTNAGVTPGLIRV 548
Query: 372 SVGLEPLDELIEDIDNAL 389
SVG+E +D++ ED AL
Sbjct: 549 SVGIEHVDDIREDFAQAL 566
>dbj|BAB06322.1| (AP001516) O-acetylhomoserine sulfhydrylase [Bacillus halodurans]
Length = 430
Score = 191 bits (480), Expect = 1e-47
Identities = 121/369 (32%), Positives = 189/369 (50%), Gaps = 37/369 (10%)
Query: 57 YSREENPTVRKLEDKLAELEGSDNALAFNSGMSAISTLYFSLLEGGDKVVLSMEGYGTTI 116
Y+R NPT E ++A LEG ALA SG +AI+ ++ E GD++V + YG T
Sbjct: 58 YTRLMNPTTDVFEKRVAALEGGAAALATASGQAAITYSILNIAEAGDEIVSASSLYGGTY 117
Query: 117 ELAKL-LRKFGVDVKLAYPS-ADSLIETIDEETKLVLVETMTNPTLKVIDVPEVAKRCRE 174
L + L K GV+V+ PS ++ I E+TK + E++ NP V+D+ VAK +
Sbjct: 118 NLFSITLPKLGVNVRFVDPSDPENFKAAITEKTKAIFAESIGNPKGDVLDIEAVAKVAHD 177
Query: 175 VGAILVVDNTFVTPLLYKPLEDGASYVVHSLTKYIAGHNDVLGGAVLWNGEFS------- 227
L+VDNTF +P L +P++ GA VVHS TK+I GH +GG ++ G F
Sbjct: 178 HHLPLIVDNTFPSPYLLQPIKHGADIVVHSATKFIGGHGTSIGGIIVDGGTFDWAKTDRY 237
Query: 228 --------------------------RDLWEWRRRLGTIIQPFDAWMIERGMRTLEVRFE 261
+ + R +G I PF+++++ +G+ TL +R E
Sbjct: 238 PGLTTPDPSYHGVVYTDAVGPIAYIIKARVQLLRDMGAAISPFNSFLLLQGLETLHLRME 297
Query: 262 RQSENAMAIAEFLKDHPKVREVHYPGLKDDPYYKVARRLFKKDLYGGVVAFDLGSGDNAL 321
R SENA +AEFL+ H V V Y GL P Y +A++ K G ++ F++ G A
Sbjct: 298 RHSENAYKVAEFLEQHQAVESVSYSGLPSHPSYPLAKKYLPKG-QGAILTFEVKGGVEAG 356
Query: 322 AFLRGLKRIFPS-PSLGGVESIATYPVKSAAKTLDEEIREILGITDGLIRLSVGLEPLDE 380
L ++F ++G +S+ +P + + L E + G+T G+IRLSVG E + +
Sbjct: 357 KKLIHSVQLFSHLANVGDSKSLIIHPASTTHQQLSEAEQRDAGVTPGMIRLSVGTESIHD 416
Query: 381 LIEDIDNAL 389
+I D+ A+
Sbjct: 417 IITDLKQAI 425
>emb|CAA18941.1| (AL023514) O-succinylhomoserine sulfhydrylase [Mycobacterium
leprae]
Length = 426
Score = 189 bits (474), Expect = 6e-47
Identities = 118/343 (34%), Positives = 188/343 (54%), Gaps = 14/343 (4%)
Query: 57 YSREENPTVRKLEDKLAELEGSDNALAFNSGMSAISTLYFSLLEGGDKVVLSMEGYGTTI 116
YSR NPTV E++L +EG+ A SGM+A+ T +LL GD++V + +G+
Sbjct: 87 YSRYGNPTVTMFEERLRLIEGAPAAFVTASGMAAVFTSLGALLASGDRLVAARSLFGSCF 146
Query: 117 ELA-KLLRKFGVDVKLAYPSADSLIE---TIDEETKLVLVETMTNPTLKVIDVPEVAKRC 172
+ ++L ++GV+ + + L++ + T+ V ET +NP ++D+ V +
Sbjct: 147 VVCNEILPRWGVET--VFVDGEDLVQWEQALSVPTQAVFFETPSNPMQSLVDIAAVTELA 204
Query: 173 REVGAILVVDNTFVTPLLYKPLEDGASYVVHSLTKYIAGHNDVLGGAVLWNGEF-SRDLW 231
GA +V+DN F TPLL L G V++S TK+I G VLGGA+L + ++ +
Sbjct: 205 HAAGAKVVLDNAFATPLLQHGLPLGVDVVIYSGTKHIDGQGRVLGGAILGDRDYIDGPVQ 264
Query: 232 EWRRRLGTIIQPFDAWMIERGMRTLEVRFERQSENAMAIAEFLKDHPKVREVHYPGLKDD 291
+ R G + F+AW++ +G+ TL +R + + +A IAEFL+ HP V V YP L
Sbjct: 265 KLMRHTGPAMSAFNAWILLKGLETLAIRVDHCNSSAHRIAEFLEKHPAVSWVRYPFLVSH 324
Query: 292 PYYKVARRLFKKDLYGGVVAFDLGSGDN-----ALAFLRGLKRIFPSPSLGGVESIATYP 346
P Y +A+R G VV F L S ++ A L L+ I S + G V+S+ T+P
Sbjct: 325 PQYDLAKRQMSGG--GTVVTFALNSPEDAAKQRAFEVLDRLRLIDISNNFGDVKSLITHP 382
Query: 347 VKSAAKTLDEEIREILGITDGLIRLSVGLEPLDELIEDIDNAL 389
+ + + E R +G+ DG++R+S+GLE +LI DID AL
Sbjct: 383 ATTTHRAMGPEGRAAIGLGDGVVRISIGLEDAADLIADIDQAL 425
>pir||S71228 O-succinylhomoserine (thiol)-lyase (EC 4.2.99.9) 1 - Arabidopsis
thaliana
Length = 311
Score = 188 bits (473), Expect = 8e-47
Identities = 113/311 (36%), Positives = 175/311 (55%), Gaps = 6/311 (1%)
Query: 86 SGMSAISTLYFSLLEGGDKVVLSMEGYGTT-IELAKLLRKFGVDVKLAYPSADSLIETID 144
SGM A + + +L+ G +V + + Y T I + L K G+ V + P+ + +E
Sbjct: 3 SGMCASTVMLLALVPAGGHIVTTTDCYRKTRIFMENFLPKLGITVTVIDPADIAGLEAAV 62
Query: 145 EETK--LVLVETMTNPTLKVIDVPEVAKRCREVGAILVVDNTFVTPLLYKPLEDGASYVV 202
E K L+ +E+ TNP L+ +D+ V+K C + G ++ +D TF TPL K L GA VV
Sbjct: 63 NEFKVSLLFIESPTNPFLRCVDIELVSKICHKRGTLVCIDGTFATPLNQKALALGADLVV 122
Query: 203 HSLTKYIAGHNDVLGGAVLWNGEFSRDLWEWRRRLGTIIQPFDAWMIERGMRTLEVRFER 262
HS TKYI GHNDVL G + + + ++ LG + P A++I RGM+T +R ++
Sbjct: 123 HSATKYIGGHNDVLAGCICGSLKLVSEIRNLHHVLGGTLNPNAAYLIIRGMKTGHLRVQQ 182
Query: 263 QSENAMAIAEFLKDHPKVREVHYPGLKDDPYYKVARRLFKKDLYGGVVAFDL-GSGDNAL 321
Q+ A +AE L+ HPKV V+YPGL P +++A+R + +GGVV+F++ G + +
Sbjct: 183 QNSTAFRMAEILEAHPKVSHVYYPGLPSHPEHELAKR--QMTGFGGVVSFEIDGDIETTI 240
Query: 322 AFLRGLKRIFPSPSLGGVESIATYPVKSAAKTLDEEIREILGITDGLIRLSVGLEPLDEL 381
F+ LK + +PS GG ESI P + L +E R GI D L+R S G+E +++
Sbjct: 241 KFVDSLKIPYIAPSFGGCESIVDQPAIMSYWDLPQEERLKYGIKDNLVRFSFGVEDFEDV 300
Query: 382 IEDIDNALGVV 392
DI AL +
Sbjct: 301 KADILQALEAI 311
>gb|AAF20155.1|AF211176_1 (AF211176) cystathionine beta-lyase [Botryotinia fuckeliana]
Length = 459
Score = 187 bits (470), Expect = 2e-46
Identities = 122/362 (33%), Positives = 200/362 (54%), Gaps = 14/362 (3%)
Query: 33 PLYITAVFKQVGDAYPTDRGTELKYSREENPTVRKLEDKLAELEGSDNALAFNSGMSAIS 92
P+Y +A FKQ G+E Y+R NPT LE LA++ ++ AL SGM A+
Sbjct: 70 PIYQSATFKQ----NLAGGGSEYDYTRSGNPTRTHLERHLAKIMNANRALVVGSGMGALD 125
Query: 93 TLYFSLLEGGDKVVLSMEGYGTTIELAKLLR-KFGVDVK-LAYPSADSLIETIDEETKLV 150
+ +L GD+V+ + YG T L L G+ V + + D + + +T +V
Sbjct: 126 VIT-RVLRPGDEVITGDDLYGGTNRLLTYLAANTGIIVHHVDTTTPDKVKAVLGPKTAMV 184
Query: 151 LVETMTNPTLKVIDVPEVAKRCREVG--AILVVDNTFVTPLLYKPLEDGASYVVHSLTKY 208
L+ET TNP +K++D+ +A+ E+ A++VVDNT ++P+L PL+ GA V S TKY
Sbjct: 185 LLETPTNPLIKIVDIATIARTAHELNEKALVVVDNTMLSPMLCNPLDLGADIVYESGTKY 244
Query: 209 IAGHNDVLGGAVLWNGEFSRD-LWEWRRRLGTIIQPFDAWMIERGMRTLEVRFERQSENA 267
++GH+D++ G + +N D ++ G + P D++++ RG++TL +R ERQ NA
Sbjct: 245 LSGHHDIMAGVLAFNDPAIGDKMYFTINSTGCGLSPNDSFLLMRGIKTLAIRMERQQTNA 304
Query: 268 MAIAEFLKDHPKVREVHYPGLKDDPYYKVARRLFKKDLYGGVVAFDLGSGDNALAFLRGL 327
AIAEFL+ H V YPGLK P Y + + + G V++F+ G + +
Sbjct: 305 QAIAEFLETHG--FRVRYPGLKSHPQYDLHWSMARG--AGAVLSFETGDVALSERIVEAA 360
Query: 328 KRIFPSPSLGGVESIATYPVKSAAKTLDEEIREILGITDGLIRLSVGLEPLDELIEDIDN 387
K S S G V S+ + P + + ++D + R+ + + +IRL VG+E +++LI+D+
Sbjct: 361 KLWGISVSFGCVNSLISMPCQMSHASIDAKTRKERQMPEDIIRLCVGIEDVNDLIDDLSR 420
Query: 388 AL 389
AL
Sbjct: 421 AL 422
>pir||D72324 O-acetylhomoserine sulfhydrylase - Thermotoga maritima (strain
MSB8) >gi|4981416|gb|AAD35963.1|AE001753_19 (AE001753)
O-acetylhomoserine sulfhydrylase [Thermotoga maritima]
Length = 430
Score = 186 bits (467), Expect = 4e-46
Identities = 124/369 (33%), Positives = 193/369 (51%), Gaps = 38/369 (10%)
Query: 57 YSREENPTVRKLEDKLAELEGSDNALAFNSGMSAISTLYFSLLEGGDKVVLSMEGYGTTI 116
Y+R NPTV LE+++A LE ALA SG +AI+ ++ GD++V YG T
Sbjct: 58 YTRIGNPTVSVLEERIAALEEGVGALAVASGQAAITYAILNIAGPGDEIVSGSALYGGTY 117
Query: 117 ELAK--LLRKFGVDVKLAYPSADSLIE-TIDEETKLVLVETMTNPTLKVIDVPEVAKRCR 173
L + L +K G+ VK + IE I E+TK V +ET+ NP L V D +A+
Sbjct: 118 NLFRHTLYKKSGIIVKFVDETDPKNIEEAITEKTKAVYLETIGNPGLTVPDFEAIAEIAH 177
Query: 174 EVGAILVVDNTFVTPLLYKPLEDGASYVVHSLTKYIAGHNDVLGGAVLWNGEF------- 226
G L+VDNT V P +++P E GA VV+S TK+I GH +GG ++ +G+F
Sbjct: 178 RHGVPLIVDNT-VAPYIFRPFEHGADIVVYSATKFIGGHGTSIGGLIVDSGKFDWTNGKF 236
Query: 227 -------------------------SRDLWEWRRRLGTIIQPFDAWMIERGMRTLEVRFE 261
++ + R LG+ + PF+A++ G+ TL +R +
Sbjct: 237 PELVEPDPSYHGVSYVETFKEAAYIAKCRTQLLRDLGSCMSPFNAFLFILGLETLSLRMK 296
Query: 262 RQSENAMAIAEFLKDHPKVREVHYPGLKDDPYYKVARRLFKKDLYGGVVAFDLGSGDNA- 320
+ ENA+ I EFLK HP V V+YP + + + A + + K+ YG +V F + G A
Sbjct: 297 KHCENALKIVEFLKSHPAVSWVNYPIAEGNKTRENALK-YLKEGYGAIVTFGVKGGKEAG 355
Query: 321 LAFLRGLKRIFPSPSLGGVESIATYPVKSAAKTLDEEIREILGITDGLIRLSVGLEPLDE 380
F+ L I ++G ++A +P + + L EE + G+T +IRLSVG+E +++
Sbjct: 356 KKFIDSLTLISHLANIGDARTLAIHPASTTHQQLTEEEQLKTGVTPDMIRLSVGIEDVED 415
Query: 381 LIEDIDNAL 389
+I D+D AL
Sbjct: 416 IIADLDQAL 424
>dbj|BAA13427.1| (D87664) QAH/OAS sulfhydrylase [Thermus aquaticus]
Length = 422
Score = 185 bits (466), Expect = 6e-46
Identities = 135/406 (33%), Positives = 202/406 (49%), Gaps = 56/406 (13%)
Query: 33 PLYITAVF-----KQVGDAYPTDRGTELKYSREENPTVRKLEDKLAELEGSDNALAFNSG 87
P+Y A + ++ + + T G Y+R+++PT R LE++L LEG+D A+A SG
Sbjct: 27 PIYAVAAYGFKTLEEGAERFATGEG--YVYARQKDPTARALEERLKALEGADYAVALASG 84
Query: 88 MSAISTLYFSLLEGGDKVVLS------MEGYGTTIELAKLLRKFG-VDVKLAYPSADSLI 140
+A +LL GD+VV + E + A++L G V V+ P D +
Sbjct: 85 QAATFAALLALLRQGDEVVAARGLFRGQEPPKSGGFSARVLGPHGGVRVRYVDPEPDRVR 144
Query: 141 ETIDEETKLVLVETMTNPTLKVIDVPEVAKRCREVGAILVVDNTF-VTPLLYKPLEDGAS 199
E + T+ + VET+ NP L + D+ +A E G L+VDNTF L +PL GA
Sbjct: 145 EALSPSTRAIFVETLANPALYIPDLEGLASLAEEKGVALIVDNTFGAAGALCRPLRWGAH 204
Query: 200 YVVHSLTKYIAGHNDVLGGAVLWNGEFSRDLWEWRR------------------------ 235
VV SLTK+ +G VLGGAVL SRD W R
Sbjct: 205 VVVQSLTKWASGTGSVLGGAVL-----SRDTALWARYPQFLEKDPRGQVPWEALGGRCYP 259
Query: 236 ---------RLGTIIQPFDAWMIERGMRTLEVRFERQSENAMAIAEFLKDHPKVREVHYP 286
LG + PF A+++ +G+ T+ +R R SE A +AE L+ HPKV+ + YP
Sbjct: 260 ERVRTLGLSLLGMALSPFHAYLLFQGLETVALRVARMSETAHFLAERLQGHPKVKALRYP 319
Query: 287 GLKDDPYYKVARRLFKKDLYGGVVAFDLGSGDNALAFLRGLKRIFPSPSLGGVESIATYP 346
GL+ DP + R+ +G ++ DLGS + A FLR + + + +LG ++ +P
Sbjct: 320 GLEGDPAHGRPRKYL--SAFGPMLTLDLGSQEAASRFLRAIP-LPKAANLGDARTLLVHP 376
Query: 347 VKSAAKTLDEEIREILGITDGLIRLSVGLEPLDELIEDIDNALGVV 392
+ L EE R G+T GL+R+SVGLE ++L+ AL VV
Sbjct: 377 WTTTHSRLPEEGRLQAGVTPGLVRVSVGLEAPEDLLGMFREALEVV 422
>pir||A75306 O-acetylhomoserine (thiol)-lyase/O-acetylserine (thiol)-lyase -
Deinococcus radiodurans (strain R1)
>gi|6459982|gb|AAF11730.1|AE002051_6 (AE002051)
O-acetylhomoserine (thiol)-lyase/O-acetylserine
(thiol)-lyase [Deinococcus radiodurans]
Length = 418
Score = 184 bits (462), Expect = 2e-45
Identities = 128/389 (32%), Positives = 199/389 (50%), Gaps = 38/389 (9%)
Query: 33 PLYITAVFK-----QVGDAYPTDRGTELKYSREENPTVRKLEDKLAELEGSDNALAFNSG 87
P++ A F+ Q D + + G L Y+R +NPTVR LE++L LEG +A SG
Sbjct: 35 PIHAAAAFQFDTLEQAQDEFQYNGG--LSYARIQNPTVRALEERLTVLEGGAATVALASG 92
Query: 88 MSAISTLYFSLLEGGDKVVLSMEGYG-TTIELAKLLRKFGVDVKLAYPSADSLIETIDEE 146
+A T S+ GD VV S +G +T L +L G+ L + + + +
Sbjct: 93 QAASLTAILSVCRAGDHVVSSASLFGGSTGMLTNILPLMGITATLVEGHPEQIRAAMQDN 152
Query: 147 TKLVLVETMTNPTLKVIDVPEVAKRCREVGAILVVDNTFV-TPLLYKPLEDGASYVVHSL 205
T+LV E ++NP+ V DV +A E GA+L +DNT L +PL+ GA V SL
Sbjct: 153 TRLVWAEMISNPSGAVADVEALAGVAHERGALLAIDNTCGGVGYLCRPLDHGADIVSQSL 212
Query: 206 TKYIAGHNDVLGGAVLWN-------------GEFS------RDLWEWRRR------LGTI 240
TK+ GH V+GG+V GE S D WR+R LG
Sbjct: 213 TKWAGGHGSVMGGSVTVGTQHDLSRNPIYAGGENSLLEQRGADALAWRQRWFGAHQLGMT 272
Query: 241 IQPFDAWMIERGMRTLEVRFERQSENAMAIAEFLKDHPKVREVHYPGLKDDPYYKVARRL 300
+ P A++I +G+ TL +R +R+S++A+A+A +L HP+V V Y GL P + + ++
Sbjct: 273 LAPHSAFLIAQGLETLGLRLQRESDSALALARWLGQHPRVGGVSYAGLPGHPSFPLVQKY 332
Query: 301 FKKDLYGGVVAFDLGSGDNALAFLRGLKRIFPSPSLGGVESIATYPVKSAAKTLDEEIRE 360
+ G V+ F++ D+ FL L+ + +P+LG V ++ +P + + E R
Sbjct: 333 LPRGA-GAVLTFEV---DDPSRFLSRLRVLRMAPNLGDVRTLVVHPWTTTHGRVPEAARH 388
Query: 361 ILGITDGLIRLSVGLEPLDELIEDIDNAL 389
G+T G IR+SVG+E + +L DI+ AL
Sbjct: 389 AAGVTPGTIRMSVGVEDVMDLQADIEQAL 417
>sp|P24601|METB_HERAU PROBABLE CYSTATHIONINE GAMMA-SYNTHASE (CGS) (O-SUCCINYLHOMOSERINE
(THIOL)-LYASE) >gi|94539|pir||S14030 probable
O-succinylhomoserine (thiol)-lyase (EC 4.2.99.9) -
Herpetosiphon aurantiacus (fragment)
>gi|581261|emb|CAA38939.1| (X55140) ORF homologous to
E.coli metB [Herpetosiphon aurantiacus]
Length = 319
Score = 182 bits (457), Expect = 6e-45
Identities = 111/295 (37%), Positives = 167/295 (55%), Gaps = 18/295 (6%)
Query: 33 PLYITAVFKQ--VGDAYPTDRGTELKYSREENPTVRKLEDKLAELEGSDNALAFNSGMSA 90
P+Y T+ + Q VGD T +YSR +NPT L+ LA LE + +AL F SG+ A
Sbjct: 26 PIYQTSTYAQRGVGDH------TGYEYSRTDNPTRTALQTCLAALEEAKHALVFASGLGA 79
Query: 91 ISTLYFSLLEGGDKVVLSMEGYGTTIEL-AKLLRKFGVD---VKLAYPSADSLIETIDEE 146
+TL +L+ GD V+ + YG T L +++ + G+ + +A P A + I
Sbjct: 80 STTLML-MLKAGDHVICGDDVYGGTYRLFQRVMTEHGLSFDFIDMADPEA--VRAAIKPN 136
Query: 147 TKLVLVETMTNPTLKVIDVPEVAKRCREVGAILVVDNTFVTPLLYKPLEDGASYVVHSLT 206
T+L+ +ET TNP LK+ + + + RE G +VDNTF +P +P+ GA V+HS T
Sbjct: 137 TRLIWLETPTNPLLKLAPIAAITRVAREHGIWTIVDNTFASPYNQRPITLGADMVLHSTT 196
Query: 207 KYIAGHNDVLGGAVLW-NGEFSRDLWEWRRRLGTIIQPFDAWMIERGMRTLEVRFERQSE 265
KYI GH+DV+GGA++ N E L + G + PFD W++ RG++TL +R
Sbjct: 197 KYIGGHSDVVGGAIMTSNDELYEKLKFLQNAAGAVPGPFDCWLVLRGVKTLSIRMRDDER 256
Query: 266 NAMAIAEFLKDHPKVREVHYPGLKDDPYYKVARRLFKKDLYGGVVAFDLGSGDNA 320
NA+AIA+FL +HP V +V YPGL P + +AR + +GG+++ L G A
Sbjct: 257 NALAIAQFLTEHPGVEKVIYPGLPSHPQHNLAREQMRG--FGGMISILLKGGAEA 309
>pir||C70846 probable metC protein - Mycobacterium tuberculosis (strain H37RV)
>gi|2894250|emb|CAA17112.1| (AL021841) metC
[Mycobacterium tuberculosis]
Length = 449
Score = 182 bits (456), Expect = 8e-45
Identities = 116/372 (31%), Positives = 179/372 (47%), Gaps = 36/372 (9%)
Query: 57 YSREENPTVRKLEDKLAELEGSDNALAFNSGMSAISTLYFSLLEGGDKVVLSMEGYGTTI 116
Y+R NPT +E ++A LEG AL +SG +A + +L GD +V S YG T
Sbjct: 67 YTRIGNPTTDVVEQRIAALEGGVAALFLSSGQAAETFAILNLAGAGDHIVSSPRLYGGTY 126
Query: 117 ELAKL-LRKFGVDVKLAYP--SADSLIETIDEETKLVLVETMTNPTLKVIDVPEVAKRCR 173
L L K G++V D+ + TK ET++NP + ++D P V++
Sbjct: 127 NLFHYSLAKLGIEVSFVDDPDDLDTWQAAVRPNTKAFFAETISNPQIDLLDTPAVSEVAH 186
Query: 174 EVGAILVVDNTFVTPLLYKPLEDGASYVVHSLTKYIAGHNDVLGGAVLWNGEFS------ 227
G L+VDNT TP L +PL GA VVHS TKY+ GH + G ++ G F
Sbjct: 187 RNGVPLIVDNTIATPYLIQPLAQGADIVVHSATKYLGGHGAAIAGVIVDGGNFDWTQGRF 246
Query: 228 -------------------------RDLWEWRRRLGTIIQPFDAWMIERGMRTLEVRFER 262
+ + R G+ PF+A+++ +G+ TL +R ER
Sbjct: 247 PGFTTPDPSYHGVVFAELGPPAFALKARVQLLRDYGSAASPFNAFLVAQGLETLSLRIER 306
Query: 263 QSENAMAIAEFLKDHPKVREVHYPGLKDDPYYKVARRLFKKDLYGGVVAFDLGSGDNA-L 321
NA +AEFL V V+Y GL P+++ A+RL K G V++F+L G A
Sbjct: 307 HVANAQRVAEFLAARDDVLSVNYAGLPSSPWHERAKRLAPKGT-GAVLSFELAGGIEAGK 365
Query: 322 AFLRGLKRIFPSPSLGGVESIATYPVKSAAKTLDEEIREILGITDGLIRLSVGLEPLDEL 381
AF+ LK ++G V S+ +P + L + G++ GL+RL+VG+E +D++
Sbjct: 366 AFVNALKLHSHVANIGDVRSLVIHPASTTHAQLSPAEQLATGVSPGLVRLAVGIEGIDDI 425
Query: 382 IEDIDNALGVVR 393
+ D++ R
Sbjct: 426 LADLELGFAAAR 437
>gb|AAD31520.2|AF144102_1 (AF144102) cystathionine-gamma-synthase [Solanum tuberosum]
Length = 583
Score = 181 bits (454), Expect = 1e-44
Identities = 115/344 (33%), Positives = 182/344 (52%), Gaps = 8/344 (2%)
Query: 55 LKYSREENPTVRKLEDKLAELEGSDNALAFNSGMSAISTLYFSLLEGGDKVVLSMEGYGT 114
L +R NPT LE+K++ LEG+++ L SGM A + ++ +L G +V + + Y
Sbjct: 201 LNMARYGNPTTVVLEEKISALEGAESTLIVASGMCASTVMFLALDAAGGHIVTTTDCYRK 260
Query: 115 T-IELAKLLRKFGVDVKLAYPSADSLIETIDEETK--LVLVETMTNPTLKVIDVPEVAKR 171
T + + +L K G+ + P+ +E + K L E+ TNP L+ +D+ V+K
Sbjct: 261 TRVFIETILPKMGITATVIDPADMGALELTLNQKKVDLFFTESPTNPFLRCVDIELVSKL 320
Query: 172 CREVGAILVVDNTFVTPLLYKPLEDGASYVVHSLTKYIAGHNDVLGGAVLWNGEFSRDLW 231
CRE GA++ +D TF TPL K L GA VVHS TK++ GHNDVL G + + +
Sbjct: 321 CREKGALVCIDGTFATPLNQKALALGADLVVHSATKFLGGHNDVLAGCISGPEKLVSVIR 380
Query: 232 EWRRRLGTIIQPFDAWMIERGMRTLEVRFERQSENAMAIAEFLKDHPKVREVHYPGLKDD 291
LG + P A++ RG +R + + + +AE L+ HPKV+ V+YPGL
Sbjct: 381 NLHHILGGALNPNAAYLAIRGRGLNHLRDSTKIQLHLRMAEILEAHPKVKHVYYPGLPSH 440
Query: 292 PYYKVARRLFKKDLYGGVVAFDLGSGD--NALAFLRGLKRIFPSPSLGGVESIATYPVKS 349
P Y +A++ + +GGVV+F++ GD F+ L+ +PS G +SI P
Sbjct: 441 PEYHLAKK--QMTGFGGVVSFEV-DGDLLTTAKFVDALRIPKIAPSFEGCKSIVDQPAIM 497
Query: 350 AAKTLDEEIREILGITDGLIRLSVGLEPLDELIEDIDNALGVVR 393
+ L + R GI D L+R S G+E +++ D+ AL +R
Sbjct: 498 SYWDLSQSDRAKYGILDNLVRFSFGVEDFEDVKADVLQALDSIR 541
>gb|AAG21602.1|AC051630_3 (AC051630) cystathionine gamma-synthase, putative; 4884-7220
[Arabidopsis thaliana]
Length = 373
Score = 178 bits (446), Expect = 1e-43
Identities = 108/341 (31%), Positives = 181/341 (52%), Gaps = 7/341 (2%)
Query: 56 KYSREENPTVRKLEDKLAELEGSDNALAFNSGMSAISTLYFSLLEGGDKVVLSMEGYGTT 115
+Y+R NPT LE+K++ LEG+++ L SGM A + + +L+ +V + + Y T
Sbjct: 36 EYARYGNPTTMALEEKISVLEGAESTLVMASGMYASNVMLLALVPTNGHIVATKDCYKET 95
Query: 116 -IELAKLLRKFGVDVKLAYPSADSLIETI--DEETKLVLVETMTNPTLKVIDVPEVAKRC 172
I + L K G+ V + ++T+ + E L E+ TNP L+ +D+ V+K C
Sbjct: 96 RIFMENFLTKLGITVTFIDSDDIAGLQTLVNNHEVSLFFTESPTNPFLRCVDIKLVSKIC 155
Query: 173 REVGAILVVDNTFVTPLLYKPLEDGASYVVHSLTKYIAGHNDVLGGAVLWNGEFSRDLWE 232
G ++ +D T TP+ K L GA V HS TKYI GHND L G++ + E +
Sbjct: 156 HRRGTLVCIDATIATPINQKTLALGADLVHHSATKYIGGHNDFLAGSISGSMELVSKIRN 215
Query: 233 WRRRLGTIIQPFDAWMIERGMRTLEVRFERQSENAMAIAEFLKDHPKVREVHYPGLKDDP 292
+ LG + P A+++ RGM+T+ +R +Q+ M +A+ L+ HPKV V+Y GL P
Sbjct: 216 LHKLLGGTLNPNAAYLLIRGMKTMHLRVRQQNSTGMKMAQVLEAHPKVSRVYYLGLPSHP 275
Query: 293 YYKVARRLFKKDLYGGVVAFDL-GSGDNALAFLRGLKRIFPSPSLGGVESIATYPVKSAA 351
+ +A+R + GG+++F++ G + F+ LK + + S GG ES+ + +
Sbjct: 276 EHLIAKR--QMTGIGGLISFEIDGDLKTTIKFIDALKIPYLAASFGGCESLVD-QLATGI 332
Query: 352 KTLDEEIREILGITDGLIRLSVGLEPLDELIEDIDNALGVV 392
+ E R G D L+R S G+E +++ D+ AL +
Sbjct: 333 WDIPREERLKDGFQDNLVRFSFGIEDFEDIKADVLQALETI 373
>gb|AAG27903.1|AC027035_2 (AC027035) cystathionine gamma-synthase, putative [Arabidopsis
thaliana]
Length = 412
Score = 178 bits (446), Expect = 1e-43
Identities = 108/341 (31%), Positives = 181/341 (52%), Gaps = 7/341 (2%)
Query: 56 KYSREENPTVRKLEDKLAELEGSDNALAFNSGMSAISTLYFSLLEGGDKVVLSMEGYGTT 115
+Y+R NPT LE+K++ LEG+++ L SGM A + + +L+ +V + + Y T
Sbjct: 75 EYARYGNPTTMALEEKISVLEGAESTLVMASGMYASNVMLLALVPTNGHIVATKDCYKET 134
Query: 116 -IELAKLLRKFGVDVKLAYPSADSLIETI--DEETKLVLVETMTNPTLKVIDVPEVAKRC 172
I + L K G+ V + ++T+ + E L E+ TNP L+ +D+ V+K C
Sbjct: 135 RIFMENFLTKLGITVTFIDSDDIAGLQTLVNNHEVSLFFTESPTNPFLRCVDIKLVSKIC 194
Query: 173 REVGAILVVDNTFVTPLLYKPLEDGASYVVHSLTKYIAGHNDVLGGAVLWNGEFSRDLWE 232
G ++ +D T TP+ K L GA V HS TKYI GHND L G++ + E +
Sbjct: 195 HRRGTLVCIDATIATPINQKTLALGADLVHHSATKYIGGHNDFLAGSISGSMELVSKIRN 254
Query: 233 WRRRLGTIIQPFDAWMIERGMRTLEVRFERQSENAMAIAEFLKDHPKVREVHYPGLKDDP 292
+ LG + P A+++ RGM+T+ +R +Q+ M +A+ L+ HPKV V+Y GL P
Sbjct: 255 LHKLLGGTLNPNAAYLLIRGMKTMHLRVRQQNSTGMKMAQVLEAHPKVSRVYYLGLPSHP 314
Query: 293 YYKVARRLFKKDLYGGVVAFDL-GSGDNALAFLRGLKRIFPSPSLGGVESIATYPVKSAA 351
+ +A+R + GG+++F++ G + F+ LK + + S GG ES+ + +
Sbjct: 315 EHLIAKR--QMTGIGGLISFEIDGDLKTTIKFIDALKIPYLAASFGGCESLVD-QLATGI 371
Query: 352 KTLDEEIREILGITDGLIRLSVGLEPLDELIEDIDNALGVV 392
+ E R G D L+R S G+E +++ D+ AL +
Sbjct: 372 WDIPREERLKDGFQDNLVRFSFGIEDFEDIKADVLQALETI 412
>gb|AAG20508.1| (AE005123) O-acetyl homoserine; Hal [Halobacterium sp. NRC-1]
Length = 431
Score = 177 bits (445), Expect = 2e-43
Identities = 126/399 (31%), Positives = 190/399 (47%), Gaps = 44/399 (11%)
Query: 33 PLYITA--VFKQVGDA---YPTDRGTELKYSREENPTVRKLEDKLAELEGSDNALAFNSG 87
PLY T F+ DA + +R + YSR NPTV L+D+LA LEG A+A SG
Sbjct: 28 PLYQTTSYAFEDSADAAGQFALERDGYI-YSRLMNPTVETLQDRLAALEGGVGAVATASG 86
Query: 88 MSAISTLYFSLLEGGDKVVLSMEGYGTTIE-LAKLLRKFGVDVKLA-YPSADSLIETIDE 145
M+A+ F L GD VV + + YG T+ L ++ GVD D+ + ID
Sbjct: 87 MAALDLATFLLARAGDSVVAASDLYGGTVTYLTHSAQRRGVDTTFVDVLDYDAYADAIDA 146
Query: 146 ETKLVLVETMTNPTLKVIDVPEVAKRCREVGAILVVDNTFVTPLLYKPLEDGASYVVHSL 205
+T VLVET+ NP+L D+ +A + G L+VDNTF TP L P++ GA V HS
Sbjct: 147 DTAYVLVETVGNPSLITPDLERIADIAHDNGVPLLVDNTFATPALATPIDHGADIVWHST 206
Query: 206 TKYIAGHNDVLGGAVLWNGEFSRD----------------------------------LW 231
TK+I G +GGA++ G F D +
Sbjct: 207 TKWIHGAGTTVGGALVDAGSFDWDAHAADYPEIAQENPAYHGVTFTDRFGDAAFTYAAIA 266
Query: 232 EWRRRLGTIIQPFDAWMIERGMRTLEVRFERQSENAMAIAEFLKDHPKVREVHYPGLKDD 291
R LG PFDAW + + TL +R ++ NA +AE L+DHP V V+YPGL D
Sbjct: 267 RGLRDLGNQQSPFDAWQTLQKLETLPLRMQQHCRNAQLVAEHLRDHPNVSWVNYPGLADH 326
Query: 292 PYYKVARRLFKKDLYGGVVAFDLGSG-DNALAFLRGLKRIFPSPSLGGVESIATYPVKSA 350
+ A YGG++ F + G + A + ++G +++ +P +
Sbjct: 327 DTHDNATTYLDSG-YGGMLTFGVEDGYEAAQSVTEETTLASLLANVGDAKTLVIHPASTT 385
Query: 351 AKTLDEEIREILGITDGLIRLSVGLEPLDELIEDIDNAL 389
+ L E + G+ ++R+SVG+E +++ D++ A+
Sbjct: 386 HQQLTPEAQRAGGVRPEMVRVSVGIEDPADIVADLETAI 424
>pir||T40463 O-acetylhomoserine (thiol)-lyase (EC 4.2.99.10) - fission yeast
(Schizosaccharomyces pombe) >gi|2331221|gb|AAB66879.1|
(AF012876) homocysteine synthase [Schizosaccharomyces
pombe] >gi|3947875|emb|CAA22286.1| (AL034382)
homocysteine synthase (EC 4.2.99.10).
[Schizosaccharomyces pombe]
Length = 429
Score = 175 bits (440), Expect = 6e-43
Identities = 120/373 (32%), Positives = 187/373 (49%), Gaps = 39/373 (10%)
Query: 57 YSREENPTVRKLEDKLAELEGSDNALAFNSGMSAISTLYFSLLEGGDKVVLSMEGYGTTI 116
YSR NPT E ++A LE A+A +SG SA+ +L + GD +V + YG T
Sbjct: 57 YSRMMNPTADVFEKRIAALEHGAAAIATSSGTSALFMALTTLAKAGDNIVSTSYLYGGTY 116
Query: 117 ELAKL-LRKFGVDVKLAY-PSADSLIETIDEETKLVLVETMTNPTLKVIDVPEVAKRCRE 174
L K+ L + G+ K + L IDE TK V VE++ NP V D +A+
Sbjct: 117 NLFKVTLPRLGITTKFVNGDDPNDLAAQIDENTKAVYVESIGNPMYNVPDFERIAEVAHA 176
Query: 175 VGAILVVDNTF-VTPLLYKPLEDGASYVVHSLTKYIAGHNDVLGGAVLWNGEF-----SR 228
G L+VDNTF L +P++ GA V HS TK+I GH +GG ++ +G+F S+
Sbjct: 177 AGVPLMVDNTFGGGGYLVRPIDHGADIVTHSATKWIGGHGTTIGGVIVDSGKFDWKKNSK 236
Query: 229 DLWEWR-----------------------------RRLGTIIQPFDAWMIERGMRTLEVR 259
E+ R +G PF +++ +G+ TL +R
Sbjct: 237 RFPEFNEPHPGYHGMVFTETFGNLAYAFACRTQTLRDVGGNANPFGVFLLLQGLETLSLR 296
Query: 260 FERQSENAMAIAEFLKDHPKVREVHYPGLKDDPYYKVARRLFKKDLYGGVVAFDL-GSGD 318
ER +NA A+A++L+ HPKV V YPGL+ +K+A++ + K+ YG V++F G D
Sbjct: 297 MERHVQNAFALAKYLEKHPKVNWVSYPGLESHVSHKLAKK-YLKNGYGAVLSFGAKGGPD 355
Query: 319 NALAFLRGLKRIFPSPSLGGVESIATYPVKSAAKTLDEEIREILGITDGLIRLSVGLEPL 378
+ + LK ++G +++ P + L +E + G+T LIR++VG+E +
Sbjct: 356 QSRKVVNALKLASQLANVGDAKTLVIAPAYTTHLQLTDEEQISAGVTKDLIRVAVGIEHI 415
Query: 379 DELIEDIDNALGV 391
D++I D AL V
Sbjct: 416 DDIIADFAQALEV 428
>emb|CAB95232.1| (AL359773) cystathionine beta-lyase [Leishmania major]
Length = 506
Score = 161 bits (404), Expect = 1e-38
Identities = 115/378 (30%), Positives = 190/378 (49%), Gaps = 28/378 (7%)
Query: 29 PLHDPLYITAVFKQ--VGDAYPTDRGTELKYSREENPTVRKLEDKLAELEGSDNALAFNS 86
P P+Y TA F Q + + P D YSR NPT +E +A LEG+ A AF+S
Sbjct: 127 PTSMPIYQTATFVQPDIEEFGPYD------YSRSGNPTRTAIETLVANLEGAHAAFAFSS 180
Query: 87 GMSAISTLYFSLLEGGDKVVLSMEGYG----TTIELAKLLRKFGVDVKLAYPSADSLIET 142
GM+A+ TL + L GD ++ S + YG ++ L V V + A
Sbjct: 181 GMAALQTLV-TTLNAGDTILASSDLYGGMHRLLTQITSCLGMTVVFVPMWDTEAVRQALV 239
Query: 143 IDEETKLVLVETMTNPTLKVIDVPEVAKRCREVGAILVVDNTFVTPLLYKPLEDGASYVV 202
+ KL+ +E+ TNP ++++D+ V + + +DNT ++PL PL G Y +
Sbjct: 240 DNPAAKLLHMESPTNPLMRIVDIRAVCEAAHAHNVKVSIDNTMMSPLRCTPLALGCDYSI 299
Query: 203 HSLTKYIAGHNDVLGGAVLWNGEFS-RDLWEWRRRLGTIIQPFDAWMIERGMRTLEVRFE 261
HS TK++ GH+D + G + E + + + G + PFD W++ RG+RTL +R E
Sbjct: 300 HSATKFLCGHSDTMCGLICVKSEEDVKRVAFLQNAQGNALAPFDCWLLLRGIRTLSIRVE 359
Query: 262 RQSENAMAIAEFL-KDHPKVREVHYPGLKDDPYYKVARRLFKKDLY---------GGVVA 311
+Q NA+A+A FL + V +HY GL +++ L +++ Y G V++
Sbjct: 360 KQELNAVAVALFLSRQSHVVSRLHYAGLNPATSPQIS-SLTEENFYLHRSQTSGPGSVLS 418
Query: 312 FDLGSGDNALAFLRGLKRIFPSPSLGGVESIATYPVKSAAKTLDEEIREILGITDGLIRL 371
+ GS + AF+R K + S G S+ P + ++ +E R + LIRL
Sbjct: 419 IETGSVKRSNAFVRACKLFKLTVSFGSCNSLVEMPCLLSHASIPKEKRT---LPVDLIRL 475
Query: 372 SVGLEPLDELIEDIDNAL 389
SVG+E +++++ D+ A+
Sbjct: 476 SVGIEQIEDILADLTQAI 493
>pir||JC1362 cystathionine gamma-lyase (EC 4.4.1.1) - human
>gi|262474|gb|AAB24699.1| (S52028) cystathionine
gamma-lyase, cystathionase {EC 4.4.1.1} [human, liver,
Peptide, 361 aa] [Homo sapiens]
Length = 361
Score = 161 bits (403), Expect = 1e-38
Identities = 114/359 (31%), Positives = 179/359 (49%), Gaps = 50/359 (13%)
Query: 33 PLYITAVFKQVGDAYPTDRGTELKYSREENPTVRKLEDKLAELEGSDNALAFNSGMSAIS 92
P+ ++ FKQ + + +YSR NPT LE +A L+G+ LAF SG++A
Sbjct: 40 PISLSTTFKQGAPG----QHSGFEYSRSGNPTRNCLEKAVAALDGAKYCLAFASGLAATV 95
Query: 93 TLYFSLLEGGDKVVLSMEGYGTTIE-LAKLLRKFGVDVKLAYPSADSLIETIDEETKLVL 151
T+ LL+ GD+++ + YG T ++ +FG+ + S L+E
Sbjct: 96 TITH-LLKAGDQIICMDDVYGGTNRYFRQVASEFGLKISFVDCSKIKLLEAA-------- 146
Query: 152 VETMTNPTLKVIDVPEVAKRCREVGAILVVDNTFVTPLLYKPLEDGASYVVHSLTKYIAG 211
+TP +PL GA ++S TKY+ G
Sbjct: 147 ----------------------------------ITPETKRPLALGADISMYSATKYMNG 172
Query: 212 HNDVLGGAVLWNGEFSRDLWEW-RRRLGTIIQPFDAWMIERGMRTLEVRFERQSENAMAI 270
H+DV+ G V N E + + + LG + P D ++ RG++TL VR E+ +N MA+
Sbjct: 173 HSDVVMGLVSVNCESLHNRLRFLQNSLGAVPSPIDCYLCNRGLKTLHVRMEKHFKNGMAV 232
Query: 271 AEFLKDHPKVREVHYPGLKDDPYYKVARRLFKKDLYGGVVAFDLGSGDNALAFLRGLKRI 330
A+FL+ +P V +V YPGL P +++ +R G V + G+ +A FL+ LK
Sbjct: 233 AQFLESNPWVEKVIYPGLPSHPQHELVKRQCT-GCTGMVTFYIKGTLQHAEIFLKNLKLF 291
Query: 331 FPSPSLGGVESIATYPVKSAAKTLDEEIREILGITDGLIRLSVGLEPLDELIEDIDNAL 389
+ SLGG ES+A P ++ + R++LGI+D LIRLSVGLE ++L+ED+D AL
Sbjct: 292 TLAESLGGFESLAELPAIMTHASVLKNDRDVLGISDTLIRLSVGLEDEEDLLEDLDQAL 350
>gi|6323333 O-Acetylhomoserine-O-Acetylserine Sulfhydralase; Met17p
[Saccharomyces cerevisiae]
>gi|127027|sp|P06106|MT17_YEAST MET17 PROTEIN [INCLUDES:
O-ACETYLHOMOSERINE SULFHYDRYLASE (OAH SULFHYDRYLASE);
O-ACETYLSERINE SULFHYDRYLASE (OAS SULFHYDRYLASE)]
>gi|83356|pir||A25539 O-acetyl homoserine-O-acetyl
serine thiol-lyase (EC 4.2.99.-) - yeast (Saccharomyces
cerevisiae) >gi|4080|emb|CAA28181.1| (X04493) OAH-OAS
sulfhydrylase (AA 1-444) [Saccharomyces cerevisiae]
>gi|596031|gb|AAB67347.1| (U17243)
O-Acetylhomoserine/Acetylserine sulfhydrylase
[Saccharomyces cerevisiae]
Length = 444
Score = 161 bits (402), Expect = 2e-38
Identities = 113/384 (29%), Positives = 191/384 (49%), Gaps = 49/384 (12%)
Query: 57 YSREENPTVRKLEDKLAELEGSDNALAFNSGMSAISTLYFSLLEGGDKVVLSMEGYGTTI 116
YSR +NPT LE+++A LEG ALA +SG +A + L GD +V + YG T
Sbjct: 56 YSRFQNPTSNVLEERIAALEGGAAALAVSSGQAAQTLAIQGLAHTGDNIVSTSYLYGGTY 115
Query: 117 ELAKL-LRKFGVDVKLAY-PSADSLIETIDEETKLVLVETMTNPTLKVIDVPEVAKRCRE 174
K+ ++FG++ + + + + DE TK V +ET+ NP V D ++ +
Sbjct: 116 NQFKISFKRFGIEARFVEGDNPEEFEKVFDERTKAVYLETIGNPKYNVPDFEKIVAIAHK 175
Query: 175 VGAILVVDNTF-VTPLLYKPLEDGASYVVHSLTKYIAGHNDVLGGAVLWNGEFS-RDL-- 230
G +VVDNTF +P++ GA V HS TK+I GH +GG ++ +G+F +D
Sbjct: 176 HGIPVVVDNTFGAGGYFCQPIKYGADIVTHSATKWIGGHGTTIGGIIVDSGKFPWKDYPE 235
Query: 231 -------------------------------WEWRRRLGTIIQPFDAWMIERGMRTLEVR 259
E R LG ++ PF ++++ +G+ TL +R
Sbjct: 236 KFPQFSQPAEGYHGTIYNEAYGNLAYIVHVRTELLRDLGPLMNPFASFLLLQGVETLSLR 295
Query: 260 FERQSENAMAIAEFLKDHPKVREVHYPGLKDDPYYKVARRLFKKDLYGGVVAF---DLGS 316
ER ENA+ +A++L+ P V V YPGL +++ A++ + + +GGV++F DL +
Sbjct: 296 AERHGENALKLAKWLEQSPYVSWVSYPGLASHSHHENAKK-YLSNGFGGVLSFGVKDLPN 354
Query: 317 GD--------NALAFLRGLKRIFPSPSLGGVESIATYPVKSAAKTLDEEIREILGITDGL 368
D + + LK ++G +++ P + K L+++ + G+T L
Sbjct: 355 ADKETDPFKLSGAQVVDNLKLASNLANVGDAKTLVIAPYFTTHKQLNDKEKLASGVTKDL 414
Query: 369 IRLSVGLEPLDELIEDIDNALGVV 392
IR+SVG+E +D++I D + V
Sbjct: 415 IRVSVGIEFIDDIIADFQQSFETV 438
>pir||S51579 cystathionine gamma-lyase (EC 4.4.1.1) 1 - Arabidopsis thaliana
(fragment) >gi|499166|emb|CAA56143.1| (X79707) CYS1
[Arabidopsis thaliana]
Length = 224
Score = 157 bits (394), Expect = 2e-37
Identities = 89/226 (39%), Positives = 132/226 (58%), Gaps = 3/226 (1%)
Query: 168 VAKRCREVGAILVVDNTFVTPLLYKPLEDGASYVVHSLTKYIAGHNDVLGGAVLWNGEFS 227
V+K C + G ++ +D TF TPL K L GA VVHS TKYI GHNDVL G + + +
Sbjct: 1 VSKICHKRGTLVCIDGTFATPLNQKALALGADLVVHSATKYIGGHNDVLAGCICGSLKLV 60
Query: 228 RDLWEWRRRLGTIIQPFDAWMIERGMRTLEVRFERQSENAMAIAEFLKDHPKVREVHYPG 287
++ LG + P A++I RGM+TL +R ++Q+ A +AE L+ HPKV V+YPG
Sbjct: 61 SEIRNLHHVLGGPLNPNAAYLIIRGMKTLHLRVQQQNSTAFRMAEILEAHPKVSHVYYPG 120
Query: 288 LKDDPYYKVARRLFKKDLYGGVVAFDL-GSGDNALAFLRGLKRIFPSPSLGGVESIATYP 346
L P +++A+R + +GGVV+F++ G + + F+ LK + +PS GG ESI P
Sbjct: 121 LPSHPEHELAKR--QMTGFGGVVSFEIDGDIETTIKFVDSLKIPYIAPSFGGCESIVDQP 178
Query: 347 VKSAAKTLDEEIREILGITDGLIRLSVGLEPLDELIEDIDNALGVV 392
+ L +E R GI D L+R S G+E +++ DI AL +
Sbjct: 179 AIMSYWDLPQEERLKYGIKDNLVRFSFGVEDFEDVKADILQALEAI 224
>gb|AAF19680.1|AC009519_14 (AC009519) F1N19.23 [Arabidopsis thaliana]
Length = 441
Score = 155 bits (389), Expect = 6e-37
Identities = 109/335 (32%), Positives = 179/335 (52%), Gaps = 24/335 (7%)
Query: 57 YSREENPTVRKLEDKLAELEGSDNALAFNSGMSAISTLYFSLLEGGDKVVLSMEGYGTTI 116
YSR NPTV L ++A LEG+ A +SGMSAIS++ L G VV + YG T
Sbjct: 95 YSRHFNPTVLNLSRQMAALEGTQAAYCTSSGMSAISSVMLQLCSSGGHVVAASTLYGGTH 154
Query: 117 EL--------AKLLRKFGVDVKLAYPSADSLIETIDEETKLVLVETMTNPTLKVIDVPEV 168
L + F VD+ A++++E T+++ E++ NPTL V D+PE+
Sbjct: 155 ALLSHFLPRTCNITTSF-VDITDHGAVANAIVE---GRTQVLYFESVANPTLTVADIPEL 210
Query: 169 AKRCREVGAILVVDNTFVTPLLYKPLEDGASYVVHSLTKYIAGHNDVLGGAVLWNGEFSR 228
++ E G +VVDNTF P++ P + GA VVHS++K+I+G D++ GAV + +
Sbjct: 211 SRMAHEKGVTVVVDNTF-APMVLSPAKLGADVVVHSISKFISGGADIIAGAVCGSENLVK 269
Query: 229 DLWEWR----RRLGTIIQPFDAWMIERGMRTLEVRFERQSENAMAIAEFLKDHPKVREVH 284
++ + R LG + A+ + + L +R S A AE ++D +V
Sbjct: 270 EMMDLRGGSLMLLGPTMNAKVAFELSERIPHLGLRMREHSHRAQVYAERMRD--LGMKVI 327
Query: 285 YPGLKDDPYYKVARRLFKKDL-YGGVVAFDLGSGDNA---LAFLRGLKRI-FPSPSLGGV 339
YPGL+ P +K+ + + +D YGG+++ D+ + + A +A+L+ + F + SLG
Sbjct: 328 YPGLETHPQHKLFKGMVNRDYGYGGLLSIDMETEEKANKLMAYLQNATQFGFMAVSLGYY 387
Query: 340 ESIATYPVKSAAKTLDEEIREILGITDGLIRLSVG 374
E++ + S + LD +E GI+ GL+R+SVG
Sbjct: 388 ETLMSCSGSSTSSELDPSQKEAAGISPGLVRMSVG 422
>pir||D47293 probable dihydrorhizobitoxine synthase RtxAB - Bradyrhizobium
japonicum (fragment)
Length = 449
Score = 155 bits (388), Expect = 8e-37
Identities = 112/362 (30%), Positives = 175/362 (47%), Gaps = 46/362 (12%)
Query: 43 VGDAYPTDRGTELKYSREENPTVRKLEDKLAELEGSDNALAFNSGMSA--ISTLYFSLLE 100
+ D Y T R Y+R NPT R LE + A ++ ++LA SG +A ++ L S E
Sbjct: 55 IADVY-TSRADGFTYTRIINPTTRALEKRYAAVDMGSDSLAVASGQAATFLAILNLSSGE 113
Query: 101 GGDKVVLSMEGYGTTIELA-KLLRKFGVDVKLAYPSADSLIE-TIDEETKLVLVETMTNP 158
GD +V S YG T L L++ G+ V+ A P E ID+ T + E ++NP
Sbjct: 114 VGDNIVASPYLYGNTWNLLHNTLKRLGISVRTADPRRPETFERAIDDRTICLFGEVISNP 173
Query: 159 TLKVIDVPEVAKRCREVGAILVVDNTFVTPLLYKPLEDGASYVVHSLTKYIAGHNDVLGG 218
L + V ++A+ R+ G LVVDNT TPL+ +P + GA+ +S TKYI GH LGG
Sbjct: 174 CLIPLPVKQLAEIGRKHGVPLVVDNT-TTPLVCRPSDLGAAITTYSATKYICGHGTTLGG 232
Query: 219 AVLWNGEFSRD------------------LWE---------------------WRRRLGT 239
++ NG+FS +W W R G
Sbjct: 233 LIVDNGKFSYRGASRFPLFNSPDEAHGGIIWRNALQDVDDLGKSEVLLKARMTWLRDTGA 292
Query: 240 IIQPFDAWMIERGMRTLEVRFERQSENAMAIAEFLKDHPKVREVHYPGLKDDPYYK-VAR 298
I PF ++ + +G+ TL +R ++ NA +A+ LK+HPKVR V YPGL + + V +
Sbjct: 293 AIAPFASFQLIQGLETLPLRMKQHCANARIVADVLKEHPKVRRVFYPGLFEGADRETVDQ 352
Query: 299 RLFKKDLYGGVVAFDLGSGDNALAFLRGLKRIFPSPSLGGVESIATYPVKSAAKTLDEEI 358
L +G +V F++ F++ + ++ ++G ++ T+PV + T+ E
Sbjct: 353 TLNPAYGHGAMVMFEVEDEQAGRKFIQNVDLMYHVSNVGDARTLVTHPVSTTHTTVPREK 412
Query: 359 RE 360
RE
Sbjct: 413 RE 414
>emb|CAA62738.1| (X91393) orf1 [Streptomyces antibioticus]
Length = 232
Score = 152 bits (379), Expect = 9e-36
Identities = 93/242 (38%), Positives = 134/242 (54%), Gaps = 19/242 (7%)
Query: 152 VETMTNPTLKVIDVPEVAKRCREVGAILVVDNTFVTPLLYKPLEDGASYVVHSLTKYIAG 211
+E+ +NP L V D+ +A GA++ VDNT TPL +PLE GA + V S TK + G
Sbjct: 1 IESPSNPGLDVCDIRRLADAAHARGALVAVDNTLATPLGQRPLELGADFSVASGTKQLTG 60
Query: 212 HNDVLGGAVLW-NGEFSRDLWEWRRRLGTIIQPFDAWMIERGMRTLEVRFERQSENAMAI 270
H DVL G V + E + WR+ +G I P +AW+ R + TL++R +RQ+ A+A+
Sbjct: 61 HGDVLLGYVAGRDAEAMAAVGRWRKIVGAISGPMEAWLAHRSIATLQLRVDRQNATALAV 120
Query: 271 AEFLKDHPKVREVHYPGLKDDPYYKVARRLFKKDLYGGVVAFDLGSGDNALAFLRGLKRI 330
AE L+ P+V + YPGL DDP + VA R ++ YG VV+F L + A FL L+ +
Sbjct: 121 AEALRQRPEVSGLRYPGLSDDPSHPVAARQMRR--YGCVVSFTLPTRARAERFLAALRLV 178
Query: 331 FPSPSLGGVESIATYPVKSAAKTLDEEIREILG---ITDGLIRLSVGLEPLDELIEDIDN 387
+ S GGV S A E R G + +G IR+SVG E ++L+ D+
Sbjct: 179 EDATSFGGVRSTA-------------ERRRRWGGDDVPEGFIRMSVGAEDPEDLVADVLR 225
Query: 388 AL 389
AL
Sbjct: 226 AL 227
>sp|Q07703|METC_BORAV CYSTATHIONINE BETA-LYASE (CBL) (BETA-CYSTATHIONASE) (CYSTEINE
LYASE) (OSTEOTOXIN) >gi|1073226|pir||A46084
cystathionine beta-lyase (EC 4.4.1.8) - Bordetella avium
>gi|304266|gb|AAA22978.1| (L10425) cystathionine
beta-lyase [Bordetella avium]
Length = 396
Score = 150 bits (376), Expect = 2e-35
Identities = 109/340 (32%), Positives = 177/340 (52%), Gaps = 18/340 (5%)
Query: 57 YSREENPTVRKLEDKLAELEGSDNALAFNSGMSAISTLYFSLLEGGDKVVLSMEGYGTTI 116
Y R T LE AELEG + +SG++ IS ++ SLL G+ +++ YG
Sbjct: 64 YGRMGMDTHAALEQVFAELEGGTHCYLASSGLAGISMVFLSLLSAGEHALVADCAYGPVH 123
Query: 117 ELAK-LLRKFGVDVKLAYPSADSLIETIDEETKLVLVETMTNPTLKVIDVPEVAKRCREV 175
EL + +L + G+DV AD L + T+L+ E + +++D+P +A+ ++
Sbjct: 124 ELHEAVLSRLGIDVTFFDAKAD-LASLVRPTTRLIFAEAPGSLLFEMLDMPALARFAKQH 182
Query: 176 GAILVVDNTFVTPLLYKPLEDGASYVVHSLTKYIAGHNDVLGGAVLWNGE-FSRDLWEWR 234
IL DNT+ + +Y+PL GA V + TKY+ GH+D++ GAV+ N E ++ L +
Sbjct: 183 DLILATDNTWGSGYIYRPLTLGAQVSVIAGTKYVGGHSDLMLGAVVTNDEAIAKRLNRTQ 242
Query: 235 RRLGTIIQPFDAWMIERGMRTLEVRFERQSENAMAIAEFLKDHPKVREVHYPGLKDDPYY 294
LG + DAW+ RG+RT+ VR + + +A+ + EFL++ P+V +++P DP
Sbjct: 243 YALGYSVSADDAWLALRGVRTMPVRMAQHARHALEVCEFLQNRPEVVRLYHPAWPADP-- 300
Query: 295 KVARRLFKKDLYG--GVVAFDLG-SGDNALAFLRGLKRIFPSPSLGGVESIA--TYPVKS 349
L+++D G G++A LG S A F+ L S GG ES+ P +
Sbjct: 301 --GHALWQRDCSGSNGMLAVQLGLSPQAARDFVNALTLFGIGFSWGGFESLVQLVTPGEL 358
Query: 350 AAKTLDEEIREILGITDGLIRLSVGLEPLDELIEDIDNAL 389
A + G +D L+RL +GLE +LI D+ AL
Sbjct: 359 ARHQYWQ------GGSDALVRLHIGLESPADLIADLAQAL 392
>sp|Q92441|MT17_KLULA MET17 PROTEIN [INCLUDES: O-ACETYLHOMOSERINE SULFHYDRYLASE (OAH
SULFHYDRYLASE); O-ACETYLSERINE SULFHYDRYLASE (OAS
SULFHYDRYLASE)] >gi|1628606|gb|AAB17387.1| (U72486)
O-acetylhomoserine sulfhydrylase [Kluyveromyces lactis]
Length = 444
Score = 150 bits (375), Expect = 3e-35
Identities = 110/384 (28%), Positives = 185/384 (47%), Gaps = 49/384 (12%)
Query: 57 YSREENPTVRKLEDKLAELEGSDNALAFNSGMSAISTLYFSLLEGGDKVVLSMEGYGTTI 116
YSR NPT+ LE +LA LEG ALA +SG +A + L GD +V + YG T
Sbjct: 55 YSRIMNPTLDVLEKRLAALEGGIAALATSSGQAAQTLAVTGLAHTGDNIVSTSFLYGGTY 114
Query: 117 ELAKL-LRKFGVDVKLAYPSADSLIETI-DEETKLVLVETMTNPTLKVIDVPEVAKRCRE 174
K+ ++ G++ + E + DE+TK + +E++ NP V D ++ +
Sbjct: 115 NQFKVAFKRLGIEARFVDGDKPEDFEKLFDEKTKALYLESIGNPKYNVPDFEKIVAVAHK 174
Query: 175 VGAILVVDNTF-VTPLLYKPLEDGASYVVHSLTKYIAGHNDVLGGAVLWNGEFS------ 227
G +VVDNTF +P++ GA V HS TK+I GH +GG ++ +G+F
Sbjct: 175 HGIPVVVDNTFGAGGFFCQPIKYGADIVTHSATKWIGGHGVTVGGVIIDSGKFPWKDYPE 234
Query: 228 -----------------RDLW-----------EWRRRLGTIIQPFDAWMIERGMRTLEVR 259
D + E R LG ++ PF +++ +G+ TL +R
Sbjct: 235 KFPQFSQPSEGYHGLIFNDAFGPAAFIGHVRTELLRDLGPVLSPFAGFLLLQGLETLSLR 294
Query: 260 FERQSENAMAIAEFLKDHPKVREVHYPGLKDDPYYKVARRLFKKDLYGGVVAFDLGSGDN 319
ER NA+ +A++L+ P V V YPGL +++ A++ + ++ +GGV++F + N
Sbjct: 295 GERHGSNALKLAQYLESSPYVSWVSYPGLPSHSHHENAKK-YLENGFGGVLSFGVKDLPN 353
Query: 320 A-----------LAFLRGLKRIFPSPSLGGVESIATYPVKSAAKTLDEEIREILGITDGL 368
A + LK ++G +++ P + + L +E + G+T L
Sbjct: 354 ASEESDPFKASGAQVVDNLKLASNLANVGDSKTLVIAPYFTTHQQLTDEEKLASGVTKDL 413
Query: 369 IRLSVGLEPLDELIEDIDNALGVV 392
IR+SVG E +D++I D + + V
Sbjct: 414 IRVSVGTEFIDDIIADFEASFATV 437
>sp|P06721|METC_ECOLI CYSTATHIONINE BETA-LYASE (CBL) (BETA-CYSTATHIONASE) (CYSTEINE
LYASE) >gi|68357|pir||WZECCB cystathionine beta-lyase
(EC 4.4.1.8) - Escherichia coli >gi|3660169|pdb|1CL2|A
Chain A, Cystathionine Beta-Lyase (Cbl) From Escherichia
Coli In Complex With Aminoethoxyvinylglycine
>gi|3660170|pdb|1CL2|B Chain B, Cystathionine Beta-Lyase
(Cbl) From Escherichia Coli In Complex With
Aminoethoxyvinylglycine >gi|146824|gb|AAA24158.1|
(M12858) beta-cystathionase [Escherichia coli]
>gi|1789383|gb|AAC76044.1| (AE000383) cystathionine
beta-lyase (beta-cystathionase) [Escherichia coli K12]
Length = 395
Score = 147 bits (367), Expect = 2e-34
Identities = 103/344 (29%), Positives = 173/344 (49%), Gaps = 19/344 (5%)
Query: 54 ELKYSREENPTVRKLEDKLAELEGSDNALAFNSGMSAISTLYFSLLEGGDKVVLSMEGYG 113
EL Y R T L+ + ELEG + F G +A++ + +E GD V+++ Y
Sbjct: 53 ELFYGRRGTLTHFSLQQAMCELEGGAGCVLFPCGAAAVANSILAFIEQGDHVLMTNTAYE 112
Query: 114 TTIEL-AKLLRKFGVDVKLAYPSADS-LIETIDEETKLVLVETMTNPTLKVIDVPEVAKR 171
+ + +K+L K GV P + +++ + TK+V +E+ + T++V DVP +
Sbjct: 113 PSQDFCSKILSKLGVTTSWFDPLIGADIVKHLQPNTKIVFLESPGSITMEVHDVPAIVAA 172
Query: 172 CREV--GAILVVDNTFVTPLLYKPLEDGASYVVHSLTKYIAGHNDVLGGAVLWNGEFSRD 229
R V AI+++DNT+ +L+K L+ G + + TKY+ GH+D + G + N
Sbjct: 173 VRSVVPDAIIMIDNTWAAGVLFKALDFGIDVSIQAATKYLVGHSDAMIGTAVCNARCWEQ 232
Query: 230 LWEWRRRLGTIIQPFDAWMIERGMRTLEVRFERQSENAMAIAEFLKDHPKVREVHYPGLK 289
L E +G ++ A++ RG+RTL VR + E+++ +AE+L +HP+V V++P L
Sbjct: 233 LRENAYLMGQMVDADTAYITSRGLRTLGVRLRQHHESSLKVAEWLAEHPQVARVNHPALP 292
Query: 290 DDPYYKVARRLFKKDLYG--GVVAFDLG---SGDNALAFLRGLKRIFPSPSLGGVES--I 342
+K+D G G+ +F L + + +L + S GG ES +
Sbjct: 293 GSK----GHEFWKRDFTGSSGLFSFVLKKKLNNEELANYLDNFSLFSMAYSWGGYESLIL 348
Query: 343 ATYPVKSAAKTLDEEIREILGITDGLIRLSVGLEPLDELIEDID 386
A P AA EI + LIRL +GLE +D+LI D+D
Sbjct: 349 ANQPEHIAAIRPQGEI----DFSGTLIRLHIGLEDVDDLIADLD 388
>pdb|1CL1|A Chain A, Cystathionine Beta-Lyase (Cbl) From Escherichia Coli
>gi|3660168|pdb|1CL1|B Chain B, Cystathionine Beta-Lyase
(Cbl) From Escherichia Coli
Length = 395
Score = 145 bits (361), Expect = 1e-33
Identities = 102/344 (29%), Positives = 172/344 (49%), Gaps = 19/344 (5%)
Query: 54 ELKYSREENPTVRKLEDKLAELEGSDNALAFNSGMSAISTLYFSLLEGGDKVVLSMEGYG 113
EL Y R T L+ + ELEG + F G +A++ + +E GD V+++ Y
Sbjct: 53 ELFYGRRGTLTHFSLQQAMCELEGGAGCVLFPCGAAAVANSILAFIEQGDHVLMTNTAYE 112
Query: 114 TTIEL-AKLLRKFGVDVKLAYPSADS-LIETIDEETKLVLVETMTNPTLKVIDVPEVAKR 171
+ + +K+L K GV P + +++ + TK+V +E+ + T++V DVP +
Sbjct: 113 PSQDFCSKILSKLGVTTSWFDPLIGADIVKHLQPNTKIVFLESPGSITMEVHDVPAIVAA 172
Query: 172 CREV--GAILVVDNTFVTPLLYKPLEDGASYVVHSLTKYIAGHNDVLGGAVLWNGEFSRD 229
R V AI+++DNT+ +L+K L+ G + + T Y+ GH+D + G + N
Sbjct: 173 VRSVVPDAIIMIDNTWAAGVLFKALDFGIDVSIQAATXYLVGHSDAMIGTAVCNARCWEQ 232
Query: 230 LWEWRRRLGTIIQPFDAWMIERGMRTLEVRFERQSENAMAIAEFLKDHPKVREVHYPGLK 289
L E +G ++ A++ RG+RTL VR + E+++ +AE+L +HP+V V++P L
Sbjct: 233 LRENAYLMGQMVDADTAYITSRGLRTLGVRLRQHHESSLKVAEWLAEHPQVARVNHPALP 292
Query: 290 DDPYYKVARRLFKKDLYG--GVVAFDLG---SGDNALAFLRGLKRIFPSPSLGGVES--I 342
+K+D G G+ +F L + + +L + S GG ES +
Sbjct: 293 GSK----GHEFWKRDFTGSSGLFSFVLKKKLNNEELANYLDNFSLFSMAYSWGGYESLIL 348
Query: 343 ATYPVKSAAKTLDEEIREILGITDGLIRLSVGLEPLDELIEDID 386
A P AA EI + LIRL +GLE +D+LI D+D
Sbjct: 349 ANQPEHIAAIRPQGEI----DFSGTLIRLHIGLEDVDDLIADLD 388
>gb|AAA69175.1| (U28377) beta-cystathionase [Escherichia coli]
Length = 421
Score = 144 bits (360), Expect = 2e-33
Identities = 102/344 (29%), Positives = 172/344 (49%), Gaps = 19/344 (5%)
Query: 54 ELKYSREENPTVRKLEDKLAELEGSDNALAFNSGMSAISTLYFSLLEGGDKVVLSMEGYG 113
EL Y R T L+ + ELEG + F G +A++ + +E GD V+++ Y
Sbjct: 79 ELFYGRRGTLTHFSLQQAMCELEGGAGCVLFPCGAAAVANSILAFIEQGDHVLMTNTAYE 138
Query: 114 TTIEL-AKLLRKFGVDVKLAYPSADS-LIETIDEETKLVLVETMTNPTLKVIDVPEVAKR 171
+ + +K+L K GV P + +++ + TK+V +E+ + T++V DVP +
Sbjct: 139 PSQDFCSKILSKLGVTTSWFDPLIGADIVKHLQPNTKIVFLESPGSITMEVHDVPAIVAA 198
Query: 172 CREV--GAILVVDNTFVTPLLYKPLEDGASYVVHSLTKYIAGHNDVLGGAVLWNGEFSRD 229
R V AI+++DNT+ +L+K L+ G + + TKY+ GH+D + G +
Sbjct: 199 VRSVVPDAIIMIDNTWAAGVLFKALDFGIDVSIQAATKYLVGHSDAMIGTAVCXARCWEQ 258
Query: 230 LWEWRRRLGTIIQPFDAWMIERGMRTLEVRFERQSENAMAIAEFLKDHPKVREVHYPGLK 289
L E +G ++ A++ RG+RTL VR + E+++ +AE+L +HP+V V++P L
Sbjct: 259 LRENAYLMGQMVDADTAYITSRGLRTLGVRLRQHHESSLKVAEWLAEHPQVARVNHPALP 318
Query: 290 DDPYYKVARRLFKKDLYG--GVVAFDLG---SGDNALAFLRGLKRIFPSPSLGGVES--I 342
+K+D G G+ +F L + + +L + S GG ES +
Sbjct: 319 GSK----GHEFWKRDFTGSSGLFSFVLKKKLNNEELANYLDNFSLFSMAYSWGGYESLIL 374
Query: 343 ATYPVKSAAKTLDEEIREILGITDGLIRLSVGLEPLDELIEDID 386
A P AA EI + LIRL +GLE +D+LI D+D
Sbjct: 375 ANQPEHIAAIRPQGEI----DFSGTLIRLHIGLEDVDDLIADLD 414
>pir||C81284 cystathionine beta-lyase truncated homolog Cj1393 [imported] -
Campylobacter jejuni (strain NCTC 11168)
>gi|6968824|emb|CAB73818.1| (AL139078) putative
cystathionine beta-lyase [Campylobacter jejuni]
Length = 348
Score = 144 bits (360), Expect = 2e-33
Identities = 102/351 (29%), Positives = 173/351 (49%), Gaps = 19/351 (5%)
Query: 49 TDRGTELKYSREENPTVRKLEDKLAELEGSDNALAFNSGMSAISTLYFSLLEGGDKVVLS 108
TDR L Y T +LE + LEG A F +G++A++ + + +++
Sbjct: 10 TDR--VLSYGARGTTTNFELEKLICTLEGGYRAQLFPTGLAALAMVLLNYASKDAHFLIT 67
Query: 109 MEGYGTTIELAKL-LRKFGVDVKLAYPSADSLIETIDEETKLVLVETMTNPTLKVIDVPE 167
YG + +L L K GV++ A + E I TKL+L E+ + ++ID+P+
Sbjct: 68 DAIYGPVRTICELFLDKIGVEIDFLKADASDIEEKIKPNTKLILCESPGSILYEIIDLPK 127
Query: 168 VAKRCREVGAILVVDNTFVTPLLYKPLEDGASYVVHSLTKYIAGHNDVLGGAVLWNGEFS 227
+ K + +DNT+ + PLE G V + TKY++GH+DV G V+ N +
Sbjct: 128 LCKIAHAYNIPVAIDNTYSSGYFLNPLELGVDISVIAATKYLSGHSDVTMGIVVINEKEW 187
Query: 228 RDLWEWRRRLGTIIQPFDAWMIERGMRTLEVRFERQSENAMAIAEFLKDHPKVREVHYPG 287
++ + LG P DA+++ RGMRTL+VR + ++A I EFL+ +++ + YP
Sbjct: 188 KNFDKLPEALGFTTSPDDAYLVLRGMRTLDVRMKAHEKSADEIVEFLQSRKEIKTIFYPK 247
Query: 288 LKDDPYYKVARRLFKKDLYG--GVVAFDLGSG---DNALAFLRGLKRIFPSPSLGGVESI 342
LK P +++ F +D G G++ + G D+A+ F+ L+ S GG ES+
Sbjct: 248 LKSHPNHEI----FMRDHKGANGMITIEFAEGYNKDDAIKFVDKLEYFSIGASWGGYESL 303
Query: 343 ATYPVKSAAKTLDEEIREILGITDGLIRLSVGLEPLDELIEDIDNALGVVR 393
AT V + +T + L +R +GLE +LI D+ A ++
Sbjct: 304 AT--VTTPPRTATD-----LSARGLFVRFHIGLEDTKDLIADLTQAFDSIK 347
>pir||T40852 cystathionine lyase precursor - fission yeast (Schizosaccharomyces
pombe) (fragment) >gi|6016989|emb|CAB57843.1| (AL121783)
cystathionine lyase precursor [Schizosaccharomyces
pombe]
Length = 290
Score = 144 bits (359), Expect = 2e-33
Identities = 83/252 (32%), Positives = 147/252 (57%), Gaps = 16/252 (6%)
Query: 146 ETKLVLVETMTNPTLKVIDVPEVAK--RCREVGAILVVDNTFVTPLLYKPLEDGASYVVH 203
+T LVL+E+ TNP + + D+ + K R + A+LV+DNT ++P+L PL+ G V
Sbjct: 39 DTNLVLIESPTNPRISICDIRAIVKITRSKAKDALLVMDNTMLSPVLCNPLDFGYDIVYE 98
Query: 204 SLTKYIAGHNDVLGGAVLW-NGEFSRDLWEWRRRLGTIIQPFDAWMIERGMRTLEVRFER 262
S TKY++GH+D++GG + + E ++ ++ +G + PF+ +++ RG++T+ +R ER
Sbjct: 99 SATKYLSGHHDLMGGVIATKSDEIAKSVFFNINAMGAAMAPFECFLLLRGIKTMGLRVER 158
Query: 263 QSENAMAIAEFLKDHPKVREVHYPGLKDDP-----YYKVARRLFKKDLYGGVVAFDLGSG 317
+NA+ IA+FLK K +V++PGL D +Y AR G V++ G
Sbjct: 159 AQQNAIEIAKFLKS--KGLQVNFPGLDPDAKSTAIFYSFARG------PGAVMSVFTGDV 210
Query: 318 DNALAFLRGLKRIFPSPSLGGVESIATYPVKSAAKTLDEEIREILGITDGLIRLSVGLEP 377
+ + + K S S G V S+ + P + ++ +E+R+ G+++ LIR+ VG+E
Sbjct: 211 EVSKTIVNTTKLFEISVSFGAVNSLISMPAYMSHASIKKEVRDARGLSEDLIRICVGIEN 270
Query: 378 LDELIEDIDNAL 389
+D+L D++NAL
Sbjct: 271 VDDLKADLENAL 282
>pir||D82171 cystathionine beta-lyase VC1671 [imported] - Vibrio cholerae (group
O1 strain N16961) >gi|9656186|gb|AAF94821.1| (AE004245)
cystathionine beta-lyase [Vibrio cholerae]
Length = 396
Score = 142 bits (354), Expect = 8e-33
Identities = 95/338 (28%), Positives = 163/338 (48%), Gaps = 12/338 (3%)
Query: 55 LKYSREENPTVRKLEDKLAELEGSDNALAFNSGMSAISTLYFSLLEGGDKVVLSMEGYGT 114
L Y R T ++ + E+EG + + G +AI+ S + GD +++ Y
Sbjct: 53 LFYGRRGTTTHFAFQEAMVEIEGGAGCVLYPCGAAAITNAILSFVAQGDHILMVDTCYEP 112
Query: 115 TIELA-KLLRKFGVDVKLAYPS-ADSLIETIDEETKLVLVETMTNPTLKVIDVPEVAKRC 172
T + K+L+K GV P + + E I TK++ E+ + T++V D+P +++
Sbjct: 113 TRDFCEKVLKKLGVSTTYYDPMLGEGIRELIQPNTKVLFTESPGSLTMEVQDIPTLSRIA 172
Query: 173 REVGAILVVDNTFVTPLLYKPLEDGASYVVHSLTKYIAGHNDVLGGAVLWNGEFSRDLWE 232
E ++++DNT+ +L+ P E G + + TKYI GH+DV+ G + N + L E
Sbjct: 173 HEHDIVVMLDNTWAAGVLFSPFEHGVDISIQAATKYIVGHSDVMLGTAVANEKCWAQLRE 232
Query: 233 WRRRLGTIIQPFDAWMIERGMRTLEVRFERQSENAMAIAEFLKDHPKVREVHYPGLKDDP 292
+G P D +M RG+RTL+VR + +N++ IA++L+ P+V V +P L P
Sbjct: 233 HSYLMGQYASPDDVYMAMRGLRTLDVRLRQHEQNSLQIAQWLQTRPEVDHVRHPALATCP 292
Query: 293 YYKVARRLFKKDLYGGVVAFDL----GSGDNALAFLRGLKRIFPSPSLGGVESIATYPVK 348
F++D GG F + A L G++ S GG ES+
Sbjct: 293 ----GHEFFERDFTGGNGLFSFVLKTTHPEATTALLDGMQHFSMGFSWGGFESLILAHEP 348
Query: 349 SAAKTLDEEIREILGITDGLIRLSVGLEPLDELIEDID 386
A +L T L+R+ +GLE +++LI D++
Sbjct: 349 KAFTSLRSVANPHFCGT--LLRVHIGLEDVEDLIADLE 384
>gi|6321254 Cystathionine beta-lyase; Str3p [Saccharomyces cerevisiae]
>gi|1723943|sp|P53101|YGT4_YEAST HYPOTHETICAL 51.8 KD
PROTEIN IN COX4-GTS1 INTERGENIC REGION
>gi|2132562|pir||S61133 probable membrane protein
YGL184c - yeast (Saccharomyces cerevisiae)
>gi|1143563|emb|CAA62790.1| (X91489) putative
cystathionine /cysteine metabolism protein
[Saccharomyces cerevisiae] >gi|1322799|emb|CAA96896.1|
(Z72706) ORF YGL184c [Saccharomyces cerevisiae]
Length = 465
Score = 141 bits (353), Expect = 1e-32
Identities = 106/381 (27%), Positives = 193/381 (49%), Gaps = 34/381 (8%)
Query: 33 PLYITAVFKQVGDAYPTDRGTELKYSREENPTVRKLEDKLAELEG--SDNALAFNSGMSA 90
P+Y++ FK + YSR NPT L+ ++ +L +N LA +SGM+A
Sbjct: 26 PVYLSTTFKV---DLNNEDAQNYDYSRSGNPTRSVLQHQIGKLYRVPQENVLAVSSGMTA 82
Query: 91 ISTLY--FSLLEGGDK----VVLSMEGYGTTIELAKLLRKFGVDVKLAYPSAD-----SL 139
+ + LL G D ++ + YG T L ++ V + ++D ++
Sbjct: 83 LDVILRGLVLLNGTDNHTPTIIAGDDLYGGTQRLLNFFKQQSHAVSVHVDTSDFEKFKTV 142
Query: 140 IETIDEETKLVLVETMTNPTLKVIDVPEVAK--RCREVGAILVVDNTFVTPLLYKPLE-- 195
+++D+ VL+E+ TNP KV+D+P + + +C +VVDNT ++ L PL+
Sbjct: 143 FQSLDK-VDCVLLESPTNPLCKVVDIPRILRFVKCISPDTTVVVDNTMMSGLNCNPLQLN 201
Query: 196 DGASYVVHSLTKYIAGHNDVLGGAVLWNG-EFSRDLWEWRRRLGTIIQPFDAWMIERGMR 254
G V S TKY+ GH+D++GG ++ E + L+ G + P D+W++ RG++
Sbjct: 202 PGCDVVYESATKYLNGHHDLMGGVIISKTPEIASKLYFVINSTGAGLSPMDSWLLVRGLK 261
Query: 255 TLEVRFERQSENAMAIAEFLKDH--------PKVREVHYPGLKDDPYYKVARRLFKKDLY 306
TL VR +Q NAM +A +L++ K + + GL+ +P +K+ + +
Sbjct: 262 TLGVRLYQQQRNAMILAHWLENSCGFKPTRTNKATKTRFVGLRSNPDFKLHKSF--NNGP 319
Query: 307 GGVVAFDLGSGDNA--LAFLRGLKRIFPSPSLGGVESIATYPVKSAAKTLDEEIREILGI 364
G V++F+ GS +++ L + L + S G V S+ + P K + ++D E+R+
Sbjct: 320 GAVLSFETGSFEHSKRLVSSKKLSIWAVTVSFGCVNSLLSMPCKMSHASIDPELRKERDF 379
Query: 365 TDGLIRLSVGLEPLDELIEDI 385
+ L+RL G+E + +L +D+
Sbjct: 380 PEDLVRLCCGIENIVDLKKDL 400
>sp|P44527|METC_HAEIN CYSTATHIONINE BETA-LYASE (CBL) (BETA-CYSTATHIONASE) (CYSTEINE
LYASE) >gi|1073898|pir||E64049 cystathionine beta-lyase
(EC 4.4.1.8) - Haemophilus influenzae (strain Rd KW20)
>gi|1573077|gb|AAC21796.1| (U32698) cystathionine
beta-lyase (metC) [Haemophilus influenzae Rd]
Length = 396
Score = 139 bits (348), Expect = 4e-32
Identities = 94/341 (27%), Positives = 169/341 (48%), Gaps = 15/341 (4%)
Query: 54 ELKYSREENPTVRKLEDKLAELEGSDNALAFNSGMSAISTLYFSLLEGGDKVVLSMEGYG 113
EL Y R T L+D + E+EG + G +A++ S ++ GD V++S Y
Sbjct: 54 ELFYGRRGTLTHFALQDLMCEMEGGAGCYLYPCGTAAVTNSILSFVKTGDHVLMSGAAYE 113
Query: 114 TTIELAKL-LRKFGVDVKLAYPSADSLIET-IDEETKLVLVETMTNPTLKVIDVPEVAKR 171
T + L+K +D+ P I T I TK++ +E ++ T+++ D+P + K
Sbjct: 114 PTQYFCNIVLKKMQIDITYYDPLIGEDIATLIQPNTKVLFLEAPSSITMEIPDIPTIVKA 173
Query: 172 CREVGA--ILVVDNTFVTPLLYKPLEDGASYVVHSLTKYIAGHNDVLGGAVLWNGEFSRD 229
R+V ++++DNT+ +L+K LE + + TKY+ GH+D++ G + N
Sbjct: 174 ARKVNPNIVIMIDNTWSAGVLFKALEHDIDISIQAGTKYLVGHSDIMIGTAVANARTWDQ 233
Query: 230 LWEWRRRLGTIIQPFDAWMIERGMRTLEVRFERQSENAMAIAEFLKDHPKVREVHYPGLK 289
L E +G ++ A+ RG+RTL VR ++ E+++ +A++L + P+V+ V++P L
Sbjct: 234 LREHSYLMGQMVDADSAYTTARGIRTLGVRLKQHQESSIKVAKWLSEQPEVKTVYHPALP 293
Query: 290 DDPYYKVARRLFKKDLYG--GVVAFDLG---SGDNALAFLRGLKRIFPSPSLGGVESIAT 344
P F +D G G+ +F+L + + F+ + + S GG ES+
Sbjct: 294 SCP----GHEFFLRDFSGSSGLFSFELTQRLTSEQVSKFMDHFQLFAMAYSWGGFESLIL 349
Query: 345 YPVKSAAKTLDEEIREILGITDGLIRLSVGLEPLDELIEDI 385
+ I+ +T LIR+ +G E +DELI D+
Sbjct: 350 CNQPEEIAHIRPNIKR--NLTGSLIRVHIGFENVDELIADL 388
>sp|P18949|METC_SALTY CYSTATHIONINE BETA-LYASE (CBL) (BETA-CYSTATHIONASE) (CYSTEINE
LYASE) >gi|79060|pir||JV0020 cystathionine beta-lyase
(EC 4.4.1.8) - Salmonella typhimurium
Length = 395
Score = 138 bits (345), Expect = 9e-32
Identities = 102/345 (29%), Positives = 172/345 (49%), Gaps = 23/345 (6%)
Query: 54 ELKYSREENPTVRKLEDKLAELEGSDNALAFNSGMSAISTLYFSLLEGGDKVVLSMEGYG 113
EL Y R T L++ + ELEG F G +A++ + +E GD ++++ Y
Sbjct: 53 ELFYGRRGTLTHFSLQEAMCELEGGAGCALFPCGAAAVANTILAFVEQGDHILMTNTAYE 112
Query: 114 TTIEL-AKLLRKFGVDVKLAYPSADS-LIETIDEETKLVLVETMTNPTLKVIDVPEVAKR 171
+ + +K+L K GV P + + + I TK+V +E+ + T++V D+P +
Sbjct: 113 PSQDFCSKILGKLGVTTSWFDPLIGADITQHIQPNTKVVFLESPGSITMEVHDIPSIVSA 172
Query: 172 CREVG--AILVVDNTFVTPLLYKPLEDGASYVVHSLTKYIAGHNDVLGGAVLWNGEFSRD 229
R V A++++DNT+ +L++ LE + + TKY+ GH+D + G + N
Sbjct: 173 VRRVAPEAVIMIDNTWAAGVLFEALEFHIDISIQAGTKYLIGHSDAMVGTAVANARCWEQ 232
Query: 230 LWEWRRRLGTIIQPFDAWMIERGMRTLEVRFERQSENAMAIAEFLKDHPKVREVHYPGLK 289
L E +G ++ A+M RG+RTL VR + E+++ IA +L +HP+V V++P L
Sbjct: 233 LRENAYLMGQMLDADTAYMTSRGLRTLGVRLRQHQESSLKIAAWLANHPQVARVNHPALP 292
Query: 290 DDPYYKVARRLFKKDLYG--GVVAFDLG---SGDNALAFLRGLKRIFPSPSLGGVES--I 342
+K+D G G+ +F L + A+L + S GG ES I
Sbjct: 293 GSK----GHAFWKRDFTGSSGLFSFVLNKKLTEAELSAYLDNFSLFSMAYSWGGYESLII 348
Query: 343 ATYPVKSAAKTLDEEIREILGI--TDGLIRLSVGLEPLDELIEDI 385
A P + AA IR G+ T L+R+ +GLE +D+LI D+
Sbjct: 349 ANQPEQIAA------IRPAGGVDFTGTLVRVHIGLESVDDLIADL 387
>gb|AAD56929.1|AF180145_21 (AF180145) cystathionine-gamma-lyase [Zymomonas mobilis]
Length = 681
Score = 135 bits (336), Expect = 1e-30
Identities = 110/371 (29%), Positives = 182/371 (48%), Gaps = 31/371 (8%)
Query: 37 TAVFKQVGD-----AYPTDRGTELKYSREENPTVRKLEDKLAELE-GSDNALAFNSGMSA 90
T +F V D ++P D +L Y R PT L + L EL G++ + + SG++A
Sbjct: 318 TILFDSVEDLREASSHPDD---QLYYGRRGTPTQWALSEALTELHPGAEATMLYPSGVAA 374
Query: 91 ISTLYFSLLEGGDKVVLSMEGYGTT-IELAKLLRKFGVDVKLAYPSADSLIETI-DEETK 148
+S S LE GD++++ Y T + +L+ G++V P IE + +T+
Sbjct: 375 LSMALLSALEAGDELLMVDSCYEPTRVFCDTVLKAQGINVTYYDPLIGQDIEQLFTPQTR 434
Query: 149 LVLVETMTNPTLKVIDVPEVAKRCREVGAILVVDNTFVTPLLYKPLEDGASYVVHSLTKY 208
+ +E+ + T +V D+P + + ++DNT+ TPL + +E G + + TKY
Sbjct: 435 AIFMESPGSLTFEVQDIPGICEVAHRYSITTILDNTW-TPLFFPAIERGVALSGMACTKY 493
Query: 209 IAGHNDVLGGAVLWNGEFSRDLWEWRRRLGTIIQPFDAWMIERGMRTLEVRFERQSENAM 268
I GH+D + G V L +G + P DA +G+RTLEVR + +NA+
Sbjct: 494 ITGHSDTMMGPVTAIPSHIDKLKRISNLIGQYVSPDDANSALKGLRTLEVRLKAHDKNAL 553
Query: 269 AIAEFLKDHPKVREVHYPGLKDDPYYKVARRLFKKDLYGGVVAFDLGSGD--NALAFLRG 326
+A++L + P+V V +P L P ++ R FK G+ +F L GD ++ A +
Sbjct: 554 KVAKWLSEQPEVAWVLHPALSSCPGHEFWHRDFKGS--SGLFSFVLEGGDDSDSTALIDS 611
Query: 327 LKRIFPSPSLGGVESIA----TYPVKSAAKTLDEEIREILGITDGLIRLSVGLEPLDELI 382
L+ S GG ES+A P+++AA ++RL +GLE D+LI
Sbjct: 612 LEHFGIGFSWGGYESLALPVDPQPIRTAAS---------WQAAGPVVRLHIGLEDPDDLI 662
Query: 383 EDIDNALGVVR 393
ED+ A G+ R
Sbjct: 663 EDL--AFGLKR 671
>gi|6321904 Cystathionine gamma-synthase; Yhr112cp [Saccharomyces cerevisiae]
>gi|731700|sp|P38716|YHR2_YEAST HYPOTHETICAL 42.4 KD
PROTEIN IN CDC12-ORC6 INTERGENIC REGION
>gi|630127|pir||S48954 hypothetical protein YHR112c -
yeast (Saccharomyces cerevisiae)
>gi|529131|gb|AAB68864.1| (U00059) Yhr112cp
[Saccharomyces cerevisiae]
Length = 378
Score = 132 bits (329), Expect = 7e-30
Identities = 106/344 (30%), Positives = 173/344 (49%), Gaps = 39/344 (11%)
Query: 57 YSREENPTVRKLEDKLAE-LEGSDNALAFNSGMSAISTLYFSLLEGGDKVVLSMEGYGTT 115
YSR +P +LE +E L+G A+ ++SG++A Y +++ K + + Y
Sbjct: 56 YSRLAHPNSTRLESIFSEILDGY--AVIYSSGLAAF---YAAMVHYNPKKIFIGQSYHGV 110
Query: 116 IELAKLL-RKFGVDVKLAYPSADSLIETIDEETKLVLVETMTNPTLKVIDVPEVAKRCRE 174
+A +L R +G++ +P D IE E +V +E+ NP D+ +A+R
Sbjct: 111 RAIANILTRNYGIE---QHPLED--IEKCASEGDIVHLESPVNPYGTSSDIESLARRAHA 165
Query: 175 VGAILVVDNTFVTPLLYKPLEDGASYVVHSLTKYIAGHNDVLGGAVLWNGE-FSRDLWEW 233
GA+L+VD+TF +P L GA V++S TKY GH+D+L G ++ E SR L +
Sbjct: 166 KGALLIVDSTFASPPLQYAWNFGADIVLYSATKYFGGHSDLLSGVLVVKEEATSRQLKDD 225
Query: 234 RRRLGTIIQPFDAWMIERGMRTLEVRFERQSENAMAIAEFLKDHPK-----VREVHYPGL 288
R LGT + +++M+ R +RT E+R +QSENA + FL DH ++ +++ L
Sbjct: 226 RIYLGTNVANLESFMLLRSLRTYEMRITKQSENATKLVRFLSDHQSEFDKVLKTIYHSSL 285
Query: 289 KDDPYYKVARRLFKKDL---YGGVVAFDLGSGDNALAFLRGLKRIFPSPSLGGVESIATY 345
+ + + KK L YG V A L + + LK + SLGG+ES+ +
Sbjct: 286 QTEEF-------VKKQLVGGYGPVFAITLYTKEQCKQLPLKLKYFHHATSLGGIESLVEW 338
Query: 346 PVKSAAKTLDEEIREILGITDGLIRLSVGLEPLDELIEDIDNAL 389
+ I LIR+SVG E ++LI+D+ +AL
Sbjct: 339 RAMTDPY-----------IDQTLIRVSVGCESANDLIKDLASAL 371
>pir||T38233 probable cystathionine gamma-synthase - fission yeast
(Schizosaccharomyces pombe) >gi|2879802|emb|CAA16988.1|
(AL021813) putative cystathionine gamma-synthase
[Schizosaccharomyces pombe]
Length = 398
Score = 115 bits (284), Expect = 1e-24
Identities = 110/381 (28%), Positives = 172/381 (44%), Gaps = 52/381 (13%)
Query: 33 PLYITAVFKQVGDAYPTDRGTELK------YSREENPTVRKLEDKLAELEGSDNALAFNS 86
P++I+ + G T+L Y+R V + E L+ + G+ + + ++S
Sbjct: 36 PIHISTTYTYPGTPDTLQPFTKLAEEDFPYYARISGNNVDRAEASLSSVLGAPSVV-YSS 94
Query: 87 GMSAISTLYFSLLEGGDKVVLS--MEGYGTTIEL-AKLLRKFGVDVKLAYPSADSLIETI 143
G++AI L S L V GY TI++ A++ R G++ D++
Sbjct: 95 GLAAIYGL-LSYLNPKHIAVHKPGFGGYSGTIQIIARINRLTGLETSFIDGKCDAI---- 149
Query: 144 DEETKLVLVETMTNPTLKVIDVPEVAKRCREVGAILVVDNTFVTPLLYKPLEDGASYVVH 203
E ++ +ET NP D+P + ++ GAILVVD+TF P + L GA YVVH
Sbjct: 150 -GEGDVIWLETPLNPLGIAFDIPFYKELAKKKGAILVVDSTFAPPPIQDALVLGADYVVH 208
Query: 204 SLTKYIAGHNDVLGGAVLWNGEFS-RDLWEWRRRLGTIIQPFDAWMIERGMRTLEVRFER 262
S TKY+AGH+DVL G DL R LGTI+ P A+++ R +RT +R +
Sbjct: 209 SATKYLAGHSDVLAGVTASKDRSKILDLKADRAYLGTILHPQQAFLLLRSLRTFPLRIAK 268
Query: 263 QSENAMAIAEFLK--------------DHPKVREVHYPGLKDDPYYKVARRLFKKDLYGG 308
SEN +A+ L D + EV++ L+ + K+L GG
Sbjct: 269 HSENGFLVAQHLNKLATDEQFATSLGIDSSLILEVYHNSLQ-------TKEFVAKNLTGG 321
Query: 309 ---VVAFDLGSGDNALAFLRGLKRIFPSPSLGGVESIATYPVKSAAKTLDEEIREILGIT 365
+ L S A LK + SLG VES+ + + +K I
Sbjct: 322 HASCFSVLLKSDTVAKHLCCELKYFHHATSLGSVESLIEWRRMTDSK-----------ID 370
Query: 366 DGLIRLSVGLEPLDELIEDID 386
L+RLS+G+E +LI D++
Sbjct: 371 PRLVRLSIGIEDAADLIADLN 391
>emb|CAB53378.1| (AJ132742) MetY protein [Bordetella bronchiseptica]
Length = 214
Score = 104 bits (258), Expect = 1e-21
Identities = 71/209 (33%), Positives = 101/209 (47%), Gaps = 23/209 (11%)
Query: 203 HSLTKYIAGHNDVLGGAVLWNGEFS----RDLWEWRRR------------------LGTI 240
+SL+KYIAGH LGGAV G + +++E R+ +G
Sbjct: 1 NSLSKYIAGHGHALGGAVTDTGLYDWSGYANIYESYRKGAPTGWGLTQIKKKGLRDMGGT 60
Query: 241 IQPFDAWMIERGMRTLEVRFERQSENAMAIAEFLKDHPKVREVHYPGLKDDPYYKVARRL 300
+ A I G TL +R R NA+A+A FL+ HP V VHYPGL ++ A L
Sbjct: 61 LAAEPAHRIAIGTETLALRMARHCSNALALATFLQGHPGVARVHYPGLSSHAQHQRASEL 120
Query: 301 FKKDLYGGVVAFDLGSGDNALAFLRGLKRIFPSPSLGGVESIATYPVKSAAKTLDEEIRE 360
F YGG++ +L G + FL L+ + + LG S+A + + E R
Sbjct: 121 FD-GRYGGLLGVELAEGIDCFDFLNRLRIVLMATHLGDTRSLALPAAHTIYYEMGAEKRA 179
Query: 361 ILGITDGLIRLSVGLEPLDELIEDIDNAL 389
+GI D LIR+SVG+E +L+ D D AL
Sbjct: 180 QMGIADSLIRVSVGIEDEADLLFDFDQAL 208
>gi|6321170 Yfr055wp [Saccharomyces cerevisiae]
>gi|1170931|sp|P43623|METC_YEAST PUTATIVE CYSTATHIONINE
BETA-LYASE (CBL) (BETA-CYSTATHIONASE) (CYSTEINE LYASE)
>gi|1084765|pir||S56311 probable membrane protein
YFR055w - yeast (Saccharomyces cerevisiae)
>gi|836811|dbj|BAA09295.1| (D50617) YFR055W
[Saccharomyces cerevisiae] >gi|871955|dbj|BAA08022.1|
(D44597) unknown [Saccharomyces cerevisiae]
Length = 340
Score = 104 bits (257), Expect = 2e-21
Identities = 77/277 (27%), Positives = 133/277 (47%), Gaps = 7/277 (2%)
Query: 30 LHDPLY--ITAVFKQVGDAYPTDRGTELKYSREENPTVRKLEDKLAELEGSDNALAFNSG 87
++ PLY T + K++ D ++ Y +PT+ LE+ L G + SG
Sbjct: 30 VNPPLYKGSTIILKKLSDL---EQRKGRFYGTAGSPTIDNLENAWTHLTGGAGTVLSASG 86
Query: 88 MSAISTLYFSLLEGGDKVVLSMEGYGTTIELAK-LLRKFGVDVKLAYPSADSLIET-IDE 145
+ +IS +L + GD ++++ Y T L LL KFGV+ PS IE +
Sbjct: 87 LGSISLALLALSKAGDHILMTDSVYVPTRMLCDGLLAKFGVETDYYDPSIGKDIEKLVKP 146
Query: 146 ETKLVLVETMTNPTLKVIDVPEVAKRCREVGAILVVDNTFVTPLLYKPLEDGASYVVHSL 205
T ++ +E+ + T++V D+P + ++ G ++DNT+ TPL + G V +
Sbjct: 147 NTTVIFLESPGSGTMEVQDIPALVSVAKKHGIKTILDNTWATPLFFDAHAHGIDISVEAG 206
Query: 206 TKYIAGHNDVLGGAVLWNGEFSRDLWEWRRRLGTIIQPFDAWMIERGMRTLEVRFERQSE 265
TKY+ GH+D+L G N E L + + D + RGMRTL +R +
Sbjct: 207 TKYLGGHSDLLIGLASANEECWPLLRSTYDAMAMLPGAEDCQLALRGMRTLHLRLKEVER 266
Query: 266 NAMAIAEFLKDHPKVREVHYPGLKDDPYYKVARRLFK 302
A+ +A +L + +V +V +P +D P ++ R +K
Sbjct: 267 KALDLAAWLGNRDEVEKVLHPAFEDCPGHEYWVRDYK 303
>sp|P38675|MET7_NEUCR CYSTATHIONINE GAMMA-SYNTHASE (O-SUCCINYLHOMOSERINE (THIOL)-LYASE)
>gi|83783|pir||JQ1524 O-succinylhomoserine (thiol)-lyase
(EC 4.2.99.9) met-7 chain - Neurospora crassa
Length = 542
Score = 91.3 bits (223), Expect = 2e-17
Identities = 101/335 (30%), Positives = 145/335 (43%), Gaps = 21/335 (6%)
Query: 72 LAELEGSDNALAFNSGMSAI----STLYFSLLEGGDKVVLSMEGYGTTIELAKLLRKFGV 127
+A L D L F GM+AI LY G + S+ ++ K+L KF
Sbjct: 206 IANLREEDIYL-FPCGMNAIFHAHRALYSIRTPPGSTPLKSVNFGFPYVDTLKILEKFNP 264
Query: 128 DVKLAYPSADSLIETIDEETKL--------VLVETMTNPTLKVIDVPEVAKRCREVGAIL 179
L Y S + D ET+L + E NP L D+ + + + +
Sbjct: 265 SGALFYGHG-SKSDLDDLETRLESGERYLALFCEFPGNPLLTCPDLVRIRELADKYEFAV 323
Query: 180 VVDNTFVTPLLYKPLEDGASYVVHSLTKYIAGHNDVLGGAVLWNGE---FSRDLWEWRRR 236
VVD T T L+ A VV SLTK +G +V+GG ++N +S +++
Sbjct: 324 VVDETIGTFANVNVLQF-ADIVVSSLTKIFSGDCNVMGGGAIFNPNSRYYSALKSFVQQQ 382
Query: 237 LGTIIQPFDAWMIERGMRTLEVRFERQSENAMAIAEFLKDHPKVREVHYPGLKDDPYYKV 296
L P D +ER R R +R + NA AI L+DHP V+ ++YP D
Sbjct: 383 LEDTYWPEDVIFMERNSRDFVARIDRVNANAEAICRVLQDHPLVKTLYYPKYNDSRANYE 442
Query: 297 ARRLFKKDLYGGVVAFDLGSGDNALAFLRGLKRIFPSPSLGGVESIATYPVKSAAKTLDE 356
A +L + YGG+++ L A+AF ++ PSL G T P A +
Sbjct: 443 AVKL-PQGGYGGLISVVLKGKKQAVAFYDAIETA-KGPSL-GTNFTLTSPYVLLAHYQEL 499
Query: 357 EIREILGITDGLIRLSVGLEPLDELIEDIDNALGV 391
+ E G+ LIR+SVGLE DELI AL V
Sbjct: 500 DWAEQYGVDRNLIRISVGLEGTDELINVFTRALKV 534
Database: ./suso.pep
Posted date: Jul 6, 2001 5:57 PM
Number of letters in database: 840,471
Number of sequences in database: 2977
Database: /banques/blast2/nr.pep
Posted date: Dec 14, 2000 12:46 PM
Number of letters in database: 188,266,275
Number of sequences in database: 595,510
Lambda K H
0.319 0.140 0.403
Gapped
Lambda K H
0.270 0.0470 0.230
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 147204405
Number of Sequences: 2977
Number of extensions: 6291393
Number of successful extensions: 17390
Number of sequences better than 1.0e-10: 132
Number of HSP's better than 0.0 without gapping: 93
Number of HSP's successfully gapped in prelim test: 39
Number of HSP's that attempted gapping in prelim test: 16872
Number of HSP's gapped (non-prelim): 154
length of query: 393
length of database: 189,106,746
effective HSP length: 56
effective length of query: 337
effective length of database: 155,591,474
effective search space: 52434326738
effective search space used: 52434326738
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 41 (21.7 bits)
S2: 166 (69.1 bits)