BLASTP 2.0.10 [Aug-26-1999]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= PAB0610 (hom) DE:homoserine dehydrogenase (hom)
         (318 letters)

Database: ./suso.pep; /banques/blast2/nr.pep
           598,487 sequences; 189,106,746 total letters

Searching..................................................done

                                                                   Score     E
Sequences producing significant alignments:                        (bits)  Value

pir||F75138 homoserine dehydrogenase (hom) PAB0610 - Pyrococcus ...   627  e-179
pir||H71101 probable homoserine dehydrogenase - Pyrococcus horik...   522  e-147
gi|11498540 homoserine dehydrogenase (hom) [Archaeoglobus fulgid...   168  6e-41
pir||A64500 homoserine dehydrogenase (EC 1.1.1.3) - Methanococcu...   162  4e-39
dbj|BAB05456.1| (AP001513) homoserine dehydrogenase [Bacillus ha...   161  1e-38
pir||C69154 homoserine dehydrogenase homolog - Methanobacterium ...   137  2e-31
emb|CAB57645.1| (Y18930) hypothetical protein [Sulfolobus solfat...   136  3e-31
gb|AAK40962.1| Homoserine dehydrogenase (thrA/hom) [Sulfolobus s...   136  3e-31
dbj|BAB07141.1| (AP001518) homoserine dehydrogenase [Bacillus ha...   131  8e-30
sp|P19582|DHOM_BACSU HOMOSERINE DEHYDROGENASE (HDH) >gi|7427665|...   129  4e-29
gb|AAA50609.1| (M23217) homoserine dehydrogenase [Bacillus subti...   129  4e-29
sp|P52985|DHOM_LACLA HOMOSERINE DEHYDROGENASE (HDH) >gi|2117450|...   129  4e-29
pir||H72364 aspartokinase II - Thermotoga maritima (strain MSB8)...   128  7e-29
pir||C70456 homoserine dehydrogenase (EC 1.1.1.3) - Aquifex aeol...   124  1e-27
pir||A75415 homoserine dehydrogenase - Deinococcus radiodurans (...   122  5e-27
pir||F69031 homoserine dehydrogenase (EC 1.1.1.3) - Methanobacte...   120  2e-26
pir||H83179 homoserine dehydrogenase PA3736 [imported] - Pseudom...   116  3e-25
sp|P08499|DHOM_CORGL HOMOSERINE DEHYDROGENASE (HDH) >gi|65915|pi...   116  4e-25
dbj|BAB04972.1| (AP001511) homoserine dehydrogenase [Bacillus ha...   114  2e-24
gb|AAF21129.1|L78665_3 (L78665) homoserine dehydrogenase [Methyl...   113  4e-24
sp|Q9ZL20|DHOM_HELPJ HOMOSERINE DEHYDROGENASE (HDH) >gi|7431118|...   111  1e-23
sp|P52986|DHOM_SYNY3 HOMOSERINE DEHYDROGENASE (HDH) >gi|7431117|...   111  1e-23
sp|P56429|DHOM_HELPY HOMOSERINE DEHYDROGENASE (HDH) >gi|7431119|...   111  1e-23
gb|AAG20683.1| (AE005137) homoserine dehydrogenase; Hom [Halobac...   109  3e-23
pir||E81106 probable homoserine dehydrogenase (EC 1.1.1.3) NMA13...   109  3e-23
sp|P46806|DHOM_MYCLE HOMOSERINE DEHYDROGENASE (HDH) >gi|7431123|...   109  5e-23
gb|AAD32592.1|AF126720_3 (AF126720) homoserine dehydrogenase [My...   108  7e-23
pir||A72716 probable homoserine dehydrogenase APE1144 - Aeropyru...   106  4e-22
emb|CAC12304.1| (AL445066) homoserine dehydrogenase related prot...   106  4e-22
pir||T06246 aspartate kinase (EC 2.7.2.4) / homoserine dehydroge...   105  6e-22
sp|Q10601|DHOM_MYCTU HOMOSERINE DEHYDROGENASE (HDH) >gi|7431115|...   104  1e-21
pir||T06242 aspartate kinase (EC 2.7.2.4) / homoserine dehydroge...   102  5e-21
pir||E81432 homoserine dehydrogenase (EC 1.1.1.3) Cj0149c [impor...   101  1e-20
pir||S46497 aspartate kinase (EC 2.7.2.4) / homoserine dehydroge...   100  2e-20
pir||H82086 aspartokinase I/homoserine dehydrogenase, threonine-...   100  2e-20
gb|AAD21689.1| (AC004793) Identical to gb|X71364 gene for aspart...   100  3e-20
sp|P44505|AKH_HAEIN BIFUNCTIONAL ASPARTOKINASE/HOMOSERINE DEHYDR...   100  3e-20
sp|P49079|AKH1_MAIZE BIFUNCTIONAL ASPARTOKINASE/HOMOSERINE DEHYD...    98  1e-19
sp|P27725|AK1H_SERMA BIFUNCTIONAL ASPARTOKINASE/HOMOSERINE DEHYD...    96  5e-19
dbj|BAA38474.1| (D10385) aspartokinase I-homoserine dehydrogenas...    96  5e-19
dbj|BAA38480.1| (D10387) aspartokinase I-homoserine dehydrogenas...    96  5e-19
sp|P49080|AKH2_MAIZE BIFUNCTIONAL ASPARTOKINASE/HOMOSERINE DEHYD...    96  5e-19
dbj|BAA38477.1| (D10386) aspartokinase I-homoserine dehydrogenas...    94  2e-18
pir||DEECK thrA bifunctional enzyme - Escherichia coli >gi|53724...    90  4e-17
sp|P37142|AKH_DAUCA BIFUNCTIONAL ASPARTOKINASE/HOMOSERINE DEHYDR...    90  4e-17
pir||T04752 aspartate kinase (EC 2.7.2.4) / homoserine dehydroge...    88  1e-16
emb|CAA23660.1| (V00361) thrA gene [EC 2.7.2.4 and EC 1.1.1.3] [...    87  3e-16
sp|P00561|AK1H_ECOLI BIFUNCTIONAL ASPARTOKINASE/HOMOSERINE DEHYD...    87  3e-16
gi|6322599 Homoserine dehydrogenase (L-homoserine:NADP oxidoredu...    87  3e-16
pdb|1EBF|A Chain A, Homoserine Dehydrogenase From S. Cerevisiae ...    87  3e-16
sp|P57290|AKH_BUCAI BIFUNCTIONAL ASPARTOKINASE/HOMOSERINE DEHYDR...    85  8e-16
pir||T03589 probable aspartate kinase (EC 2.7.2.4) / homoserine ...    84  2e-15
pir||T40673 homoserine dehydrogenase - fission yeast  (Schizosac...    84  2e-15
pir||G82583 bifunctional aspartokinase/homoserine dehydrogenase ...    83  5e-15
sp|P29365|DHOM_PSEAE HOMOSERINE DEHYDROGENASE (HDH) >gi|65916|pi...    80  3e-14
sp|P37144|DHON_METGL HOMOSERINE DEHYDROGENASE (HDH) >gi|2160268|...    80  4e-14
emb|CAB59717.1| (AL132707) putative homoserine dehydrogenase [St...    76  6e-13

>pir||F75138 homoserine dehydrogenase (hom) PAB0610 - Pyrococcus abyssi  (strain
           Orsay) >gi|5458334|emb|CAB49823.1| (AJ248285) homoserine
           dehydrogenase (hom) [Pyrococcus abyssi]
           Length = 318
           
 Score =  627 bits (1599), Expect = e-179
 Identities = 318/318 (100%), Positives = 318/318 (100%)

Query: 1   MKVKVSVFGFGTVGRALAEIIAEKRKVFGVELNVVSITDRSGTIWGDFDLLEAKEVKEST 60
           MKVKVSVFGFGTVGRALAEIIAEKRKVFGVELNVVSITDRSGTIWGDFDLLEAKEVKEST
Sbjct: 1   MKVKVSVFGFGTVGRALAEIIAEKRKVFGVELNVVSITDRSGTIWGDFDLLEAKEVKEST 60

Query: 61  GKLSNIGEYEVYDFSPQELIEEVKPDILVDVSSWDDAHEMYSYALAEGISVVTSNKPPIA 120
           GKLSNIGEYEVYDFSPQELIEEVKPDILVDVSSWDDAHEMYSYALAEGISVVTSNKPPIA
Sbjct: 61  GKLSNIGEYEVYDFSPQELIEEVKPDILVDVSSWDDAHEMYSYALAEGISVVTSNKPPIA 120

Query: 121 NHYDELITLARENGVGIFFESTVMAGTPIIGLLRENLLGEEIVKMEAIVNASTTFILTRM 180
           NHYDELITLARENGVGIFFESTVMAGTPIIGLLRENLLGEEIVKMEAIVNASTTFILTRM
Sbjct: 121 NHYDELITLARENGVGIFFESTVMAGTPIIGLLRENLLGEEIVKMEAIVNASTTFILTRM 180

Query: 181 ENGKTFEEAMEEARTLGILEEDPSKDIDGIDAYYKAKILHWVSYGEQPEEEEREGIRNVK 240
           ENGKTFEEAMEEARTLGILEEDPSKDIDGIDAYYKAKILHWVSYGEQPEEEEREGIRNVK
Sbjct: 181 ENGKTFEEAMEEARTLGILEEDPSKDIDGIDAYYKAKILHWVSYGEQPEEEEREGIRNVK 240

Query: 241 DARNVRLVAEISKGRISVAPRKLPDNSPLLVSEVENAALIKTENLTLTLKGPGGGGKVTA 300
           DARNVRLVAEISKGRISVAPRKLPDNSPLLVSEVENAALIKTENLTLTLKGPGGGGKVTA
Sbjct: 241 DARNVRLVAEISKGRISVAPRKLPDNSPLLVSEVENAALIKTENLTLTLKGPGGGGKVTA 300

Query: 301 SGVFTDIIKAALKFPSPR 318
           SGVFTDIIKAALKFPSPR
Sbjct: 301 SGVFTDIIKAALKFPSPR 318


>pir||H71101 probable homoserine dehydrogenase - Pyrococcus horikoshii
           >gi|3257491|dbj|BAA30174.1| (AP000004) 319aa long
           hypothetical homoserine dehydrogenase [Pyrococcus
           horikoshii]
           Length = 319
           
 Score =  522 bits (1329), Expect = e-147
 Identities = 256/319 (80%), Positives = 292/319 (91%), Gaps = 1/319 (0%)

Query: 1   MKVKVSVFGFGTVGRALAEIIAEKRKVFGVELNVVSITDRSGTIWGDFDLLEAKEVKEST 60
           MKV +S+FGFGTVGRALAEIIAEK ++FGVELNV+SITDRSGTIWGDFDLLEAKEVKEST
Sbjct: 1   MKVNISIFGFGTVGRALAEIIAEKSRIFGVELNVISITDRSGTIWGDFDLLEAKEVKEST 60

Query: 61  GKLSNIGEYEVYDFSPQELIEEVKPDILVDVSSWDDAHEMYSYALAEGISVVTSNKPPIA 120
           GKLSNIG+YEVY+FSPQEL+EEVKP+ILVDVSSWD+AHEMY  AL EGISVVTSNKPPIA
Sbjct: 61  GKLSNIGDYEVYNFSPQELVEEVKPNILVDVSSWDEAHEMYKVALGEGISVVTSNKPPIA 120

Query: 121 NHYDELITLARENGVGIFFESTVMAGTPIIGLLRENLLGEEIVKMEAIVNASTTFILTRM 180
           N+YDEL+ LA+EN  GIFFESTVMAGTPIIG+LRENLLGE I +++A+VNASTTFILT+M
Sbjct: 121 NYYDELMNLAKENNAGIFFESTVMAGTPIIGVLRENLLGENIKRIDAVVNASTTFILTKM 180

Query: 181 ENGKTFEEAMEEARTLGILEEDPSKDIDGIDAYYKAKILHWVSYGEQPEEEEREGIRNVK 240
             GKT ++A+EEA++LGILEEDPSKDIDGIDAYYKAKILHWVSYGE PEEEER GIR V+
Sbjct: 181 SEGKTLDDAIEEAKSLGILEEDPSKDIDGIDAYYKAKILHWVSYGEPPEEEERLGIREVR 240

Query: 241 DARNVRLVAEISKGRISVAPRKLPDNSPLLVSEVENAALIKTENL-TLTLKGPGGGGKVT 299
           DARNVRLVA++SKG+ISV PRKL  ++PLLV  V+NAA+I+T NL  + LKGPGGGG+VT
Sbjct: 241 DARNVRLVAQVSKGKISVKPRKLSSDNPLLVEGVQNAAVIRTNNLGEVILKGPGGGGRVT 300

Query: 300 ASGVFTDIIKAALKFPSPR 318
           ASGVFTDIIKA LKFP+ R
Sbjct: 301 ASGVFTDIIKATLKFPNLR 319


>gi|11498540 homoserine dehydrogenase (hom) [Archaeoglobus fulgidus]
           >gi|7431121|pir||G69366 homoserine dehydrogenase (hom)
           homolog - Archaeoglobus fulgidus
           >gi|2649661|gb|AAB90303.1| (AE001039) homoserine
           dehydrogenase (hom) [Archaeoglobus fulgidus]
           Length = 326
           
 Score =  168 bits (422), Expect = 6e-41
 Identities = 109/325 (33%), Positives = 177/325 (53%), Gaps = 28/325 (8%)

Query: 3   VKVSVFGFGTVGRALAEIIAEKR----KVFGVELNVVSITDRSGTIWGDFDLLEAKEVKE 58
           +K+++ GFGTVG+ +AE++  KR    K  G E  V ++ D   +I GDF L+EA  +K 
Sbjct: 2   IKIAIVGFGTVGQGVAELLIRKREEIEKAIG-EFKVTAVADSKSSISGDFSLVEALRMKR 60

Query: 59  STGKLSNIGEYEVYDFSPQELIEEVKPDILVDVS-SWDDAHEMYSY---ALAEGISVVTS 114
            TG L +       D    E++     D+L++ S +  D  E  +Y   AL  G  VVTS
Sbjct: 61  ETGMLRD-------DAKAIEVVRSADYDVLIEASVTRVDGGEGVNYIREALKRGKHVVTS 113

Query: 115 NKPPIANHYDELITLARENGVGIFFESTVMAGTPIIGLLRENLLGEEIVKMEAIVNASTT 174
           NK P+   +  L++LA  NGV + +E+TV    P++ L +  L   EI  ++ I N +  
Sbjct: 114 NKGPLVAEFHGLMSLAERNGVRLMYEATVGGAMPVVKLAKRYLALCEIESVKGIFNGTCN 173

Query: 175 FILTRMENGK-TFEEAMEEARTLGILEEDPSKDIDGIDAYYKAKIL-HWVSYGEQPEEEE 232
           +IL+RME  +  +E  ++EA+ LG  E DPS D++GIDA  K  I+ + +      E+ E
Sbjct: 174 YILSRMEEERLPYEHILKEAQELGYAEADPSYDVEGIDAALKLVIIANTIGVKASYEDVE 233

Query: 233 REGIRNV---------KDARNVRLVAEISKGRISVAPRKLPDNSPLLVSEVENAALIKTE 283
             GI  +         +    +RL+AE+S+ ++ V+PR +P + PL +    NAA+ KT+
Sbjct: 234 VTGITQITPEAFQVAAEKGYTIRLIAEVSREKLKVSPRLVPFHHPLAIKGTMNAAMFKTD 293

Query: 284 NL-TLTLKGPGGGGKVTASGVFTDI 307
              ++ + G G G + TAS + +D+
Sbjct: 294 TAGSIFVAGRGAGKEETASAILSDL 318


>pir||A64500 homoserine dehydrogenase (EC 1.1.1.3) - Methanococcus jannaschii
           >gi|1500499|gb|AAB99622.1| (U67600) homoserine
           dehydrogenase (hom) [Methanococcus jannaschii]
           Length = 336
           
 Score =  162 bits (407), Expect = 4e-39
 Identities = 113/327 (34%), Positives = 181/327 (54%), Gaps = 24/327 (7%)

Query: 5   VSVFGFGTVGRALAEIIAEKR---KVFGVELNVVSITDRSGTIWGD--FDLLEAKEVKES 59
           + + GFG +G+ +A+++ +K+   K    E  VV+ITD SG    +   DLL+A EVKE 
Sbjct: 3   IIIVGFGAIGKGIAKVLYDKKDYLKKNYEEFKVVAITDSSGAAIDEDGLDLLKAIEVKEK 62

Query: 60  TGKLSNIGEYEVYDFSPQELIEEVKPDILVDVS-----SWDDAHEMYSYALAEGISVVTS 114
           TGK+ N  E +  + S  ++I+EV  D++V+V+     + D A      +      VVT+
Sbjct: 63  TGKIKNYPE-KGREMSSIDVIKEVDADVVVEVTPSNLETGDPAKTHILESFKNKKHVVTA 121

Query: 115 NKPPIANHYDELITLARENGVGIFFESTVMAGTPIIGLLRENLLGEEIVKMEAIVNASTT 174
           NK P+A  Y ELI  A+++GV    E++V    PII L +E L G EI+ +  I+N +T 
Sbjct: 122 NKGPLALCYKELIEEAKKHGVIFRHEASVGGAMPIINLAKETLAGNEILSIRGILNGTTN 181

Query: 175 FILTRME-NGKTFEEAMEEARTLGILEEDPSKDIDGIDAYYKAKIL--HWVSYGEQPEEE 231
           +ILT+ME  G  FE A++EA+ LGI E DP++DI+G+D   K  IL    +   +  ++ 
Sbjct: 182 YILTKMEKEGLDFETALKEAKELGIAETDPTQDIEGLDTAAKIVILANSIMGMNKTIKDV 241

Query: 232 EREGIRNV---------KDARNVRLVAEISKGRISVAPRKLPDNSPLLVSEVENAALIKT 282
           + +GI  +         K    ++L+ +I  G + V P  +P +SPL V    N A+ +T
Sbjct: 242 KVKGISRITPEALFLANKRGYTIKLIGQIKDGYLIVEPMLVPIDSPLNVKGTLNVAMFET 301

Query: 283 E-NLTLTLKGPGGGGKVTASGVFTDII 308
           +    + + G G G   TAS + +D+I
Sbjct: 302 DLAKEVVVVGRGAGPIETASAILSDLI 328


>dbj|BAB05456.1| (AP001513) homoserine dehydrogenase [Bacillus halodurans]
           Length = 342
           
 Score =  161 bits (402), Expect = 1e-38
 Identities = 116/335 (34%), Positives = 176/335 (51%), Gaps = 27/335 (8%)

Query: 1   MKVKVSVFGFGTVGRALAEIIAEKRKVFGVELNVVSITD-RSGTIW--GDFDLLEAKEVK 57
           M  KV++ GFG V +   +I+ E+ +     + VVSITD R G +      DL    ++ 
Sbjct: 1   MTQKVALIGFGGVAQGFIQILRERGEELPEHIQVVSITDWRRGAVHDPNGLDLDFIAKII 60

Query: 58  ESTGKLSNIGEYE--VYDFSPQELIEEVKPDILVDVSSWD-----DAHEMYSYALAEGIS 110
           E+ G   +  E    +  ++  E I++   D +V+V+  D      A +    AL  G  
Sbjct: 61  ETDGTFEHYPERSGVIKGWNSFETIQQTNADTIVEVTFTDVLTGQPAIDHCKEALRLGKH 120

Query: 111 VVTSNKPPIANHYDELITLARENGVGIFFESTVMAGTPIIGLLRENLLGEEIVKMEAIVN 170
           VVT+NK PIA  Y EL  LA  NGV + +E TVM+GTP + L    L+G  I +++ I+N
Sbjct: 121 VVTTNKGPIAVAYQELKELADANGVQLLYEGTVMSGTPALRLPEHTLIGNNIQEVKGILN 180

Query: 171 ASTTFILTRMENGKTFEEAMEEARTLGILEEDPSKDIDGIDAYYKAKILHWVSYG--EQP 228
            +T +ILT ME GKTFE+A+++A+TLG  E DP+ D++G D  YK  IL  V  G   +P
Sbjct: 181 GTTNYILTEMERGKTFEQALQDAQTLGYAEADPTSDVEGYDVLYKVVILANVMMGIPLKP 240

Query: 229 EEEEREGI-----RNVKDARNV--------RLVAEISKGRISVAPRKLPDNSPLL-VSEV 274
            + ER GI     R++KDA +         R+  E  +   +V P +LP   PL  ++  
Sbjct: 241 SDVERVGISHLTPRDIKDAHSAGERWKLIGRVKKEGERTMATVRPERLPLTDPLANINGA 300

Query: 275 ENAALIKTE-NLTLTLKGPGGGGKVTASGVFTDII 308
            NA   + + +  +TL G G G K T   +  D++
Sbjct: 301 INAITYECDISGPITLIGAGAGVKETGFALLIDLL 335


>pir||C69154 homoserine dehydrogenase homolog - Methanobacterium
           thermoautotrophicum (strain Delta H)
           >gi|2621481|gb|AAB84923.1| (AE000826) homoserine
           dehydrogenase homolog [Methanobacterium
           thermoautotrophicum]
           Length = 340
           
 Score =  137 bits (341), Expect = 2e-31
 Identities = 103/330 (31%), Positives = 162/330 (48%), Gaps = 26/330 (7%)

Query: 3   VKVSVFGFGTVGRALAEIIAEK----RKVFGVELNVVSITDRSGTIWGD--FDLLEAKEV 56
           +++ + G G VG+     +  K    R+ +G+++    + D SG +      D+    E 
Sbjct: 4   MRICLVGLGAVGQGFLRAVQMKGEYLRERYGLDIRFTGVADSSGALHDPDGLDIRGVLEH 63

Query: 57  KESTGKLSNIGEYEVYDFSPQELIEEVKPDILVD-----VSSWDDAHEMYSYALAEGISV 111
           K+  G  S+   YE    +  EL++E + D LV+     +   +    +   A+ +G  V
Sbjct: 64  KKRAGLGSHPSGYE--GMTGDELLDEAEYDCLVEATPTNIEDGEPGRSLVLKAMGDGKHV 121

Query: 112 VTSNKPPIANHYDELITLARENGVGIFFESTVMAGTPIIGLLRENLLGEEIVKMEAIVNA 171
           VTSNK  +A  Y EL+  A E GV   FE++V    PII L RE L    I  +  I+N 
Sbjct: 122 VTSNKGHLALFYSELMEAASEAGVEFMFEASVGGAMPIINLARETLASCTIESVIGILNG 181

Query: 172 STTFILTRM-ENGKTFEEAMEEARTLGILEEDPSKDIDGIDAYYKAKILHWVSYGE--QP 228
           +T FIL+RM   G ++ +A+ EA+ LGI E +P++D++G DA  KA I+     G     
Sbjct: 182 TTNFILSRMASEGSSYRQALIEAQELGIAETNPAQDVEGTDAACKAVIIANSILGRPCTL 241

Query: 229 EEEEREGIRNV---------KDARNVRLVAEISKGRISVAPRKLPDNSPLLVSEVENAAL 279
            +   EGI  +         ++   ++L+AEIS  R+ V PR +   SP  V    N A 
Sbjct: 242 RDVRVEGITGITQGAIELAAQEGYLIKLIAEISGDRLEVGPRLVRMGSPYAVDGTLNMAT 301

Query: 280 IKTENL-TLTLKGPGGGGKVTASGVFTDII 308
           ++T+    +T  G G G   TAS + TD I
Sbjct: 302 LRTDLAGEVTAVGRGAGSLETASAMLTDTI 331


>emb|CAB57645.1| (Y18930) hypothetical protein [Sulfolobus solfataricus]
           Length = 314
           
 Score =  136 bits (339), Expect = 3e-31
 Identities = 97/325 (29%), Positives = 162/325 (49%), Gaps = 37/325 (11%)

Query: 3   VKVSVFGFGTVGRALAEIIAEKRKVFGV--ELNVVSITDRSGTIWGDFDLLEAKEVKEST 60
           +K+ + G+G VG+A   ++ EK+  + +   + +  I  R G + GD         KE+ 
Sbjct: 1   MKLLLIGYGNVGKAFRRLLHEKKDNYPILQGVEIAGIITRQGLMVGD---------KENF 51

Query: 61  GKLSNIGEYEVYDFSPQELIEEVKPDILVDVS-----SWDDAHEMYSYALAEGISVVTSN 115
                +   E  D+        + PD++VD+S       + +   Y  AL+  I V+T N
Sbjct: 52  SPDKQLTVLEAIDY--------INPDVIVDMSVPNYKDGEPSVSAYIKALSRKIHVITVN 103

Query: 116 KPPIANHYDELITLARENGVGIFFESTVMAGTPIIGLLRENLLGEEIVKMEAIVNASTTF 175
           K P+A  + E+  +A + G  I F+ TVM+GTP I L R   + E + ++  I+N +T +
Sbjct: 104 KAPLALKFREIFEVAEKTGAKIGFQGTVMSGTPSINLFRIQPVAE-VSRIRGILNGTTNY 162

Query: 176 ILTRMENGKTFEEAMEEARTLGILEEDPSKDIDGIDAYYKAKIL------HWVSYGEQP- 228
           ILTR+  G +F EA++EA+  G  EEDP+ D++G DA  K  IL        +  G+   
Sbjct: 163 ILTRIYEGLSFNEALKEAKEKGYAEEDPTLDLNGFDAAAKLTILSNFIMNRSLKLGDFKF 222

Query: 229 ---EEEEREGIRNVK-DARNVRLVAEISKGRISVAPRKLPDNSPL-LVSEVENAALIKTE 283
               E   E IR  K + + ++L+A      + V+P+ +    PL  +  VENA  I+ E
Sbjct: 223 KGITEITNEEIRRAKSEGKKIKLIAYADNYVVQVSPQIIGPQDPLYYIDGVENALEIQNE 282

Query: 284 NLTLTLKGPGGGGKVTASGVFTDII 308
              + ++GPG G    A G  +D++
Sbjct: 283 IQRIIIRGPGAGPINAAYGALSDLV 307


>gb|AAK40962.1| Homoserine dehydrogenase (thrA/hom) [Sulfolobus solfataricus]
           Length = 314
           
 Score =  136 bits (339), Expect = 3e-31
 Identities = 97/325 (29%), Positives = 162/325 (49%), Gaps = 37/325 (11%)

Query: 3   VKVSVFGFGTVGRALAEIIAEKRKVFGV--ELNVVSITDRSGTIWGDFDLLEAKEVKEST 60
           +K+ + G+G VG+A   ++ EK+  + +   + +  I  R G + GD         KE+ 
Sbjct: 1   MKLLLIGYGNVGKAFRRLLHEKKDNYPILQGVEIAGIITRQGLMVGD---------KENF 51

Query: 61  GKLSNIGEYEVYDFSPQELIEEVKPDILVDVS-----SWDDAHEMYSYALAEGISVVTSN 115
                +   E  D+        + PD++VD+S       + +   Y  AL+  I V+T N
Sbjct: 52  SPDKQLTVLEAIDY--------INPDVIVDMSVPNYKDGEPSVSAYIKALSRKIHVITVN 103

Query: 116 KPPIANHYDELITLARENGVGIFFESTVMAGTPIIGLLRENLLGEEIVKMEAIVNASTTF 175
           K P+A  + E+  +A + G  I F+ TVM+GTP I L R   + E + ++  I+N +T +
Sbjct: 104 KAPLALKFREIFEVAEKTGAKIGFQGTVMSGTPSINLFRIQPVAE-VSRIRGILNGTTNY 162

Query: 176 ILTRMENGKTFEEAMEEARTLGILEEDPSKDIDGIDAYYKAKIL------HWVSYGEQP- 228
           ILTR+  G +F EA++EA+  G  EEDP+ D++G DA  K  IL        +  G+   
Sbjct: 163 ILTRIYEGLSFNEALKEAKEKGYAEEDPTLDLNGFDAAAKLTILSNFIMNRSLKLGDFKF 222

Query: 229 ---EEEEREGIRNVK-DARNVRLVAEISKGRISVAPRKLPDNSPL-LVSEVENAALIKTE 283
               E   E IR  K + + ++L+A      + V+P+ +    PL  +  VENA  I+ E
Sbjct: 223 KGITEITNEEIRRAKSEGKKIKLIAYADNYVVQVSPQIIGPQDPLYYIDGVENALEIQNE 282

Query: 284 NLTLTLKGPGGGGKVTASGVFTDII 308
              + ++GPG G    A G  +D++
Sbjct: 283 IQRIIIRGPGAGPINAAYGALSDLV 307


>dbj|BAB07141.1| (AP001518) homoserine dehydrogenase [Bacillus halodurans]
           Length = 431
           
 Score =  131 bits (327), Expect = 8e-30
 Identities = 103/329 (31%), Positives = 164/329 (49%), Gaps = 40/329 (12%)

Query: 3   VKVSVFGFGTVGRALAEIIA----EKRKVFGVELNVVSITDRSGTIWGDFDLLEAKEVKE 58
           +KV + G GTVG  + ++I     E R   G+ + V  +  R        D  +A++V  
Sbjct: 5   LKVGLLGLGTVGSGVVKLIENHQQELRHQIGLPVQVEKVLVR--------DRSKARDVVL 56

Query: 59  STGKLSNIGEYEVYDFSPQELIEEVKPDILVDVSSWDD-AHEMYSYALAEGISVVTSNKP 117
           S   ++  GE         E++E    D++++V      A E    AL  G  VVT+NK 
Sbjct: 57  SEESVTLYGE---------EIVENANIDVVIEVMGGITLAKEYIVRALKNGKHVVTANKD 107

Query: 118 PIANHYDELITLARENGVGIFFESTVMAGTPIIGLLRENLLGEEIVKMEAIVNASTTFIL 177
            +A H  EL++LA ENG  +F+E++V  G PII  L + L  + I KM  IVN +T +IL
Sbjct: 108 LMAVHGAELLSLAAENGCDLFYEASVAGGIPIIRSLTDGLAADRITKMMGIVNGTTNYIL 167

Query: 178 TRM-ENGKTFEEAMEEARTLGILEEDPSKDIDGIDAYYKAKILHWVSYGEQPEEEE--RE 234
           T+M + G  +EE + +A+ LG  E DP+ D++G+DA  K  IL  + +    E ++    
Sbjct: 168 TKMTKEGLDYEEVLAQAQALGFAESDPTADVEGLDAARKMAILATLGFSMDVELDDVVVR 227

Query: 235 GIRNVKD---------ARNVRLVA----EISKGRISVAPRKLPDNSPL-LVSEVENAALI 280
           GI +V              ++L+     +  +  +SV P  LP   PL  V++  NA  +
Sbjct: 228 GISSVTKTDLEYCEQLGYTMKLIGLADRDGDRVEVSVQPTLLPKEHPLAAVNDEYNAVYV 287

Query: 281 KTENLTLTL-KGPGGGGKVTASGVFTDII 308
             E +  T+  GPG G   TA+ V +D++
Sbjct: 288 YGEAVGETMFYGPGAGSLPTATAVVSDLV 316


>sp|P19582|DHOM_BACSU HOMOSERINE DEHYDROGENASE (HDH) >gi|7427665|pir||DEECHS homoserine
           dehydrogenase (EC 1.1.1.3) - Bacillus subtilis
           >gi|2635723|emb|CAB15216.1| (Z99120) homoserine
           dehydrogenase [Bacillus subtilis]
           Length = 433
           
 Score =  129 bits (321), Expect = 4e-29
 Identities = 103/329 (31%), Positives = 166/329 (50%), Gaps = 40/329 (12%)

Query: 3   VKVSVFGFGTVGRALAEIIAEKRKVF----GVELNVVSITDRSGTIWGDFDLLEAKEVKE 58
           ++V + G GTVG  + +II + +       G  + +  +  +        DL + +EV  
Sbjct: 4   IRVGLLGLGTVGSGVVKIIQDHQDKLMHQVGCPVTIKKVLVK--------DLEKKREVDL 55

Query: 59  STGKLSNIGEYEVYDFSPQELIEEVKPDILVDVSSWDDAHEMYSY-ALAEGISVVTSNKP 117
               L+     EVYD     +I++   D++++V    +  + Y   AL     VVT+NK 
Sbjct: 56  PKEVLTT----EVYD-----VIDDPDVDVVIEVIGGVEQTKQYLVDALRSKKHVVTANKD 106

Query: 118 PIANHYDELITLARENGVGIFFESTVMAGTPIIGLLRENLLGEEIVKMEAIVNASTTFIL 177
            +A +  EL+  A+ENG  I+FE++V  G PI+  L E L  + I KM  IVN +T FIL
Sbjct: 107 LMAVYGSELLAEAKENGCDIYFEASVAGGIPILRTLEEGLSSDRITKMMGIVNGTTNFIL 166

Query: 178 TRMENGKT-FEEAMEEARTLGILEEDPSKDIDGIDAYYKAKILHWVSYGEQP--EEEERE 234
           T+M   K+ +EE ++EA+ LG  E DP+ D++G+DA  K  IL  + +      E+ + +
Sbjct: 167 TKMIKEKSPYEEVLKEAQDLGFAEADPTSDVEGLDAARKMAILARLGFSMNVDLEDVKVK 226

Query: 235 GIRNVKD---------ARNVRLVA----EISKGRISVAPRKLPDNSPLLVSEVE-NAALI 280
           GI  + D            ++L+     + SK  +SV P  LPD+ PL     E NA  +
Sbjct: 227 GISQITDEDISFSKRLGYTMKLIGIAQRDGSKIEVSVQPTLLPDHHPLSAVHNEFNAVYV 286

Query: 281 KTENLTLTL-KGPGGGGKVTASGVFTDII 308
             E +  T+  GPG G   TA+ V +D++
Sbjct: 287 YGEAVGETMFYGPGAGSMPTATSVVSDLV 315


>gb|AAA50609.1| (M23217) homoserine dehydrogenase [Bacillus subtilis]
           Length = 433
           
 Score =  129 bits (321), Expect = 4e-29
 Identities = 103/329 (31%), Positives = 166/329 (50%), Gaps = 40/329 (12%)

Query: 3   VKVSVFGFGTVGRALAEIIAEKRKVF----GVELNVVSITDRSGTIWGDFDLLEAKEVKE 58
           ++V + G GTVG  + +II + +       G  + +  +  +        DL + +EV  
Sbjct: 4   IRVGLLGLGTVGSGVVKIIQDHQDKLMHQVGCPVTIKKVLVK--------DLEKKREVDL 55

Query: 59  STGKLSNIGEYEVYDFSPQELIEEVKPDILVDVSSWDDAHEMYSY-ALAEGISVVTSNKP 117
               L+     EVYD     +I++   D++++V    +  + Y   AL     VVT+NK 
Sbjct: 56  PKEVLTT----EVYD-----VIDDPDVDVVIEVIGGVEQTKQYLVDALRSKKHVVTANKD 106

Query: 118 PIANHYDELITLARENGVGIFFESTVMAGTPIIGLLRENLLGEEIVKMEAIVNASTTFIL 177
            +A +  EL+  A+ENG  I+FE++V  G PI+  L E L  + I KM  IVN +T FIL
Sbjct: 107 LMAVYGSELLAEAKENGCDIYFEASVAGGIPILRTLEEGLSSDRITKMMGIVNGTTNFIL 166

Query: 178 TRMENGKT-FEEAMEEARTLGILEEDPSKDIDGIDAYYKAKILHWVSYGEQP--EEEERE 234
           T+M   K+ +EE ++EA+ LG  E DP+ D++G+DA  K  IL  + +      E+ + +
Sbjct: 167 TKMIKEKSPYEEVLKEAQDLGFAEADPTSDVEGLDAARKMAILARLGFSMNVDLEDVKVK 226

Query: 235 GIRNVKD---------ARNVRLVA----EISKGRISVAPRKLPDNSPLLVSEVE-NAALI 280
           GI  + D            ++L+     + SK  +SV P  LPD+ PL     E NA  +
Sbjct: 227 GISQITDEDISFSKRLGYTMKLIGIAQRDGSKIEVSVQPTLLPDHHPLSAVHNEFNAVYV 286

Query: 281 KTENLTLTL-KGPGGGGKVTASGVFTDII 308
             E +  T+  GPG G   TA+ V +D++
Sbjct: 287 YGEAVGETMFYGPGAGSMPTATSVVSDLV 315


>sp|P52985|DHOM_LACLA HOMOSERINE DEHYDROGENASE (HDH) >gi|2117450|pir||JC6049 homoserine
           dehydrogenase (EC 1.1.1.3) - Lactococcus lactis
           >gi|1255939|emb|CAA65713.1| (X96988) hom [Lactococcus
           lactis]
           Length = 428
           
 Score =  129 bits (321), Expect = 4e-29
 Identities = 95/334 (28%), Positives = 176/334 (52%), Gaps = 42/334 (12%)

Query: 1   MKVKVSVFGFGTVGRALAEIIAEKR----KVFGVELNVVSITDRSGTIWGDFDLLEAKEV 56
           M V +++ GFGTVG  L  +++E +    K+   E+ +  +  R             K +
Sbjct: 1   MAVNIAILGFGTVGTGLPTLLSENKEKLAKILDEEIVISKVLMRDN-----------KAI 49

Query: 57  KESTGKLSNIGEYEVYDF--SPQELIEEVKPDILVDVSSWDDAHEMY-SYALAEGISVVT 113
           +++  +  N      YDF  +  +++ + +  I+V++    +  + Y + A+  G +VVT
Sbjct: 50  EKARSQGFN------YDFVLNLDDILADSEISIVVELMGRIEPAKTYITQAIEAGKNVVT 103

Query: 114 SNKPPIANHYDELITLARENGVGIFFESTVMAGTPIIGLLRENLLGEEIVKMEAIVNAST 173
           +NK  +A H  EL +LA+++ V +++E+ V  G PI+  L  +   ++I  +  I+N ++
Sbjct: 104 ANKDLLAVHGVELRSLAQKHHVALYYEAAVAGGIPILRTLANSFSSDKITHLLGILNGTS 163

Query: 174 TFILTRM-ENGKTFEEAMEEARTLGILEEDPSKDIDGIDAYYKAKILHWVSYGE--QPEE 230
            F++T+M E G T++E++ +A+ LG  E DP+ D+DGIDA YK  IL   ++G    P++
Sbjct: 164 NFMMTKMSEEGWTYDESLAKAQELGYAESDPTNDVDGIDASYKLAILSEFAFGMTLAPDD 223

Query: 231 EEREGIRNVKD---------ARNVRLVAEISKGR----ISVAPRKLPDNSPLL-VSEVEN 276
             + G+R+++             ++L  EI++        V+P  LP + PL  V+ V N
Sbjct: 224 IAKSGLRSIQKTDVEIAQQFGYVLKLTGEINEVDSGIFAEVSPTFLPKSHPLASVNGVMN 283

Query: 277 AALIKTENL-TLTLKGPGGGGKVTASGVFTDIIK 309
           A  I++E +      G G G K TA+ V  DI++
Sbjct: 284 AVFIESEGIGDSVFYGAGAGQKPTATSVLADIVR 317


>pir||H72364 aspartokinase II - Thermotoga maritima (strain MSB8)
           >gi|4981061|gb|AAD35632.1|AE001729_12 (AE001729)
           aspartokinase II [Thermotoga maritima]
           Length = 739
           
 Score =  128 bits (319), Expect = 7e-29
 Identities = 103/329 (31%), Positives = 162/329 (48%), Gaps = 39/329 (11%)

Query: 2   KVKVSVFGFGTVGRALAEIIAEKRKVFGVELNVVSITDRSGTIWGDFDLLEAKEVKESTG 61
           KV+V + G GTVG ++  I+ E+            I  R G        + +K +  S  
Sbjct: 19  KVRVGIAGLGTVGGSIYRILKERGN---------EIEKRIGE-----KFIISKVINRSPQ 64

Query: 62  KLSNIG---EYEVYDFSPQELIEEVKPDILVD-VSSWDDAHEMYSYALAEGISVVTSNKP 117
           K   +G   E   +DF   +LI  +  D++V+ +   D A ++   AL  G  VVT NK 
Sbjct: 65  KYELLGVPKEEIAFDFD--DLI--LNSDVVVEAIGGTDVAVDLVRRALELGRIVVTPNKN 120

Query: 118 PIANHYDELITLARENGVGIFFESTVMAGTPIIGLLRENLLGEEIVKMEAIVNASTTFIL 177
            I+ + +E     ++    +FFE++V  G PII LL++ L+ +++ ++  I+N +T +IL
Sbjct: 121 LISEYGNEFSEYIKKRK--LFFEASVGGGIPIISLLQDYLIFQKVTRIRGIMNGTTNYIL 178

Query: 178 TRMENGKTFEEAMEEARTLGILEEDPSKDIDGIDAYYKAKILHWVSYGEQP--EEEEREG 235
           T M  G+ FEE ++EA+ LG  E DP+ DI+G D  YK  +L  V  G  P     + EG
Sbjct: 179 TEMSKGRHFEEVLKEAQELGYAEADPTNDIEGYDVAYKVSVLAGVVTGRFPGINSVQFEG 238

Query: 236 IRN---------VKDARNVRLVAEI--SKGRISVAPRKLPDNSPLL-VSEVENAALIKTE 283
           I           V+  + ++L+ E+  S  R  V  R++    P   V  V+NA  + T+
Sbjct: 239 ITRIDPEYLKEIVRSGKKLKLIGELDFSTNRYEVRLREVTPEDPFFNVDGVDNAIEVSTD 298

Query: 284 NL-TLTLKGPGGGGKVTASGVFTDIIKAA 311
                 LKG G GG  TAS V  D+ + A
Sbjct: 299 LAGDFLLKGRGAGGYPTASAVIADLFRVA 327


>pir||C70456 homoserine dehydrogenase (EC 1.1.1.3) - Aquifex aeolicus
           >gi|2984093|gb|AAC07631.1| (AE000757) homoserine
           dehydrogenase [Aquifex aeolicus]
           Length = 435
           
 Score =  124 bits (309), Expect = 1e-27
 Identities = 110/332 (33%), Positives = 165/332 (49%), Gaps = 44/332 (13%)

Query: 3   VKVSVFGFGTVGRALAEIIAEK----RKVFGVELNVVSITDRSGTIWGDFDLLEAKEVKE 58
           V+V + G GTVG   A+++ +     +K  G+E  +V + D       +F++   KE++ 
Sbjct: 4   VRVGIIGCGTVGTGTAKLLIQNADLIKKKTGIEFKLVKVADIDWERKREFEV--PKELRT 61

Query: 59  STGKLSNIGEYEVYDFSPQELIEEVKPDILVD-VSSWDDAHEMYSYALAEGISVVTSNKP 117
           +  K       EV D S          D++V+ V     A ++   AL  G  VVT+NK 
Sbjct: 62  TDYK-------EVIDNS----------DVVVELVGGKTFAKKVILEALEAGKCVVTANKH 104

Query: 118 PIANHYDELITLARENGVGIFFESTVMAGTPIIGLLRENLLGEEIVKMEAIVNASTTFIL 177
            +A    E+   A++  + I FE++V  G P+I  LRE L G +I+ +  I+N +T +IL
Sbjct: 105 LLAEEGKEIFEEAKKRNLFIGFEASVGGGIPVIKALREGLAGNKILNILGILNGTTNYIL 164

Query: 178 TRM-ENGKTFEEAMEEARTLGILEEDPSKDIDGIDAYYKAKILHWVSYGEQPEEEE--RE 234
           TRM E    FE A++EA+  G  E DPS DIDG DA +K  IL  ++YG   +  +   E
Sbjct: 165 TRMFEENLDFETALKEAKEKGYAEADPSLDIDGWDAAHKIAILAMLAYGGYLDFNDVYVE 224

Query: 235 GIRNVKDARNVRLVAEI--------------SKGRISVAPRKLPDNSPLL-VSEVENAAL 279
           GIRNV D  +V L  E+              S+  + V P  +     L  VS V NA +
Sbjct: 225 GIRNV-DKLDVELGKELGYTLKLLAIAKKVDSEVEVRVHPTFIHSEEALAKVSGVYNAVM 283

Query: 280 IKTENLTLTL-KGPGGGGKVTASGVFTDIIKA 310
           I+ + +  T+  G G G   TAS V  D+I A
Sbjct: 284 IEGDFVGKTMFYGQGAGSHPTASAVVADVIDA 315


>pir||A75415 homoserine dehydrogenase - Deinococcus radiodurans (strain R1)
           >gi|6459026|gb|AAF10850.1|AE001975_4 (AE001975)
           homoserine dehydrogenase [Deinococcus radiodurans]
           Length = 325
           
 Score =  122 bits (303), Expect = 5e-27
 Identities = 98/338 (28%), Positives = 165/338 (47%), Gaps = 47/338 (13%)

Query: 3   VKVSVFGFGTVGRALAEIIAEKRKVFG---VELNVVSITDRSGTIWGDFDLLEAKEVKES 59
           V V V G GTVG+ + ++I  +R VFG   V++ +  +  R        D+ +A+E+   
Sbjct: 4   VTVGVLGSGTVGQNVLQLIERRRPVFGDLGVQIELAGVLVR--------DVNKARELPAG 55

Query: 60  TGKLSNIGEYEVYDFSPQELIEEVKPDILVDVSSWDDAHEMYSYALAEGISVVTSNKPPI 119
                N            + ++E    ++  +   +   E+    L  G  V+T+NK  +
Sbjct: 56  VRVTDNC-----------DFLQECGV-VIEAMGGIERPLELLRPYLKSGRPVITANKALL 103

Query: 120 ANHYDELITLARENGVGIFFESTVMAGTPIIGLLRENLLGEEIVKMEAIVNASTTFILTR 179
           A  +DEL + A +    +++E++VMAGTP+IG +   L      +++A++N +  +ILT+
Sbjct: 104 AEKWDELRSYALDGD--LYYEASVMAGTPVIGPMSTVLRASTFTRLQAVLNGTCNYILTQ 161

Query: 180 MENGKTFEEAMEEARTLGILEEDPSKDIDGIDAYYKAKIL-HWVSYGEQPEEE-EREGIR 237
           ME GK +  A+ EA+ LG  E+ P+ D+ G D  +K  +L  + + G  P E+ E +GI 
Sbjct: 162 MEGGKDYAAALAEAQALGYAEDPPTLDVGGFDTAHKLAVLARFCADGNFPYEQIEVQGIE 221

Query: 238 NV---------KDARNVRLVAEISK---------GRISVAPRKLPDNSPL-LVSEVENAA 278
           +V         +    ++LVAE+ +          R  VAP+ LP + PL       NA 
Sbjct: 222 HVTLDDIEQARQRGERLKLVAELRREGHDTQRGGWRAVVAPQSLPADHPLCXAGGGRNAM 281

Query: 279 LIKTENL-TLTLKGPGGGGKVTASGVFTDIIKAALKFP 315
           + + E    L   G G GG VTAS +  D++   L FP
Sbjct: 282 VYEGEECGPLIFAGGGAGGMVTASAMVGDLLDYLLGFP 319


>pir||F69031 homoserine dehydrogenase (EC 1.1.1.3) - Methanobacterium
           thermoautotrophicum (strain Delta H)
           >gi|2622343|gb|AAB85721.1| (AE000890) homoserine
           dehydrogenase [Methanobacterium thermoautotrophicum]
           Length = 423
           
 Score =  120 bits (298), Expect = 2e-26
 Identities = 97/335 (28%), Positives = 164/335 (48%), Gaps = 43/335 (12%)

Query: 3   VKVSVFGFGTVGRALAEIIAEKRKVF----GVELNVVSITDRSGTIWGDFDLLEAKEVKE 58
           + + + GFGT+G  + EI      +     G+EL +  + D         D+   + V+ 
Sbjct: 1   MNIGLIGFGTIGAGVVEIFNTNPDIIMKKTGMELRLRRVVD--------LDIETDRGVEI 52

Query: 59  STGKLSNIGEYEVYDFSPQELIEEVKPDILVD-VSSWDDAHEMYSYALAEGISVVTSNKP 117
             G LS   +         +++E+ + DI+++ +  ++ A      A+  G  VVT+NK 
Sbjct: 53  DPGILSTDAD---------DILEDPEIDIVIELIGGYEPARSFILKAIENGKHVVTANKA 103

Query: 118 PIANHYDELITLARENGVGIFFESTVMAGTPIIGLLRENLLGEEIVKMEAIVNASTTFIL 177
            +A H+DE++  ARE+GV + FE++V  G P++  L E+L    I  +  I+N +  +IL
Sbjct: 104 LLARHWDEIMDAAREHGVRVAFEASVGGGIPVLRALNESLAANRIESIYGIINGTANYIL 163

Query: 178 TRM-ENGKTFEEAMEEARTLGILEEDPSKDIDGIDAYYKAKILHWVSYGEQPEEEER--E 234
           TRM   G  F++ + EA+ LG  E DP+ DI+G D   K  IL  + +G    E+E   E
Sbjct: 164 TRMASEGMEFDDVLREAQRLGYAERDPTFDIEGHDTAQKLIILTLLGFGVHVPEDELHVE 223

Query: 235 GIRNVKD----------ARNVRLV--AEISKG--RISVAPRKLPDNSPL-LVSEVENAAL 279
           GI +++             +V+L+  A ++ G   + V P  +P +  L  V+ V N   
Sbjct: 224 GISSIRRDDIEYATAELGCSVKLLATARLNDGELELGVTPTLVPHHHLLSSVNGVFNGIY 283

Query: 280 IKTENLT--LTLKGPGGGGKVTASGVFTDIIKAAL 312
           I T + T  +   G G G + TAS V  D +  A+
Sbjct: 284 I-TGDFTGPVMFYGKGAGRRATASAVVADCMDIAV 317


>pir||H83179 homoserine dehydrogenase PA3736 [imported] - Pseudomonas aeruginosa
           (strain PAO1) >gi|9949903|gb|AAG07123.1|AE004792_8
           (AE004792) homoserine dehydrogenase [Pseudomonas
           aeruginosa]
           Length = 434
           
 Score =  116 bits (288), Expect = 3e-25
 Identities = 100/325 (30%), Positives = 158/325 (47%), Gaps = 34/325 (10%)

Query: 3   VKVSVFGFGTVGRALAEIIAEKRKVFGVELNVVSITDRSGTIWGDFDLLEAKEVKESTGK 62
           VKV + G GTVG     ++         E N   I  R+G    +   + A+        
Sbjct: 4   VKVGICGLGTVGGGTFNVL---------ERNAEEIARRAGR-GIEVAQIAARRPNPKCDT 53

Query: 63  LSNIGEYEVYDFSPQELIEEVKPDILVD-VSSWDDAHEMYSYALAEGISVVTSNKPPIAN 121
            +     +++D +    I     D++V+ +  +  AHE+   A+  G  VVT+NK  IA 
Sbjct: 54  GATPITADIFDVACNPEI-----DVVVELIGGYTLAHELVLKAIENGKHVVTANKALIAV 108

Query: 122 HYDELITLARENGVGIFFESTVMAGTPIIGLLRENLLGEEIVKMEAIVNASTTFILTRM- 180
           H +E+   ARE GV + FE+ V  G P+I  +RE L    I  +  I+N +  FIL+ M 
Sbjct: 109 HGNEIFAKAREKGVIVAFEAAVAGGIPVIKAIREGLSANRINWLAGIINGTGNFILSEMR 168

Query: 181 ENGKTFEEAMEEARTLGILEEDPSKDIDGIDAYYKAKILHWVSYG--EQPEEEEREGIR- 237
           E G+TF + + EA+ LG  E DP+ D++GIDA +K  IL  +++G   Q ++   EGI  
Sbjct: 169 EKGRTFPDVLAEAQALGYAEADPTFDVEGIDAAHKLTILASIAFGIPLQFDKAYTEGISK 228

Query: 238 ------NVKDARNVRL----VAEISKG--RISVAPRKLPDNSPLL-VSEVENAALIKTEN 284
                 N  DA   R+    VA  ++    + V P  +P +  +  V+ V NA ++  + 
Sbjct: 229 LTSADVNYADALGYRIKHLGVARRTESGFELRVHPTLIPSDRLIANVNGVMNAVMVNGDA 288

Query: 285 LTLTL-KGPGGGGKVTASGVFTDII 308
           +  TL  G G G + TAS V  D++
Sbjct: 289 VGSTLYYGAGAGMEPTASSVVADLV 313


>sp|P08499|DHOM_CORGL HOMOSERINE DEHYDROGENASE (HDH) >gi|65915|pir||DEFKHG homoserine
           dehydrogenase (EC 1.1.1.3) - Corynebacterium glutamicum
           >gi|40503|emb|CAA68614.1| (Y00546) homoserine
           dehydrogenase (HdH) (AA 1-445) [Corynebacterium
           glutamicum] >gi|297383|emb|CAA68536.1| (Y00476)
           homoserine dehydrogenase [Corynebacterium glutamicum]
           Length = 445
           
 Score =  116 bits (287), Expect = 4e-25
 Identities = 107/334 (32%), Positives = 161/334 (48%), Gaps = 40/334 (11%)

Query: 3   VKVSVFGFGTVGRALAEIIAEKRKVFGVELNVVSITDRSGTIWGDFDLLEAKEVKESTGK 62
           V +++ GFGTVG  +  ++ E    +G EL        +  I G    LE + +  S   
Sbjct: 19  VGIALLGFGTVGTEVMRLMTE----YGDEL--------AHRIGGP---LEVRGIAVSDIS 63

Query: 63  LSNIGEY-EVYDFSPQELIEEVKPDILVDV-SSWDDAHEMYSYALAEGISVVTSNKPPIA 120
               G   E+       LIE    DI+V+V    +   E+   AL  G SVVT+NK  +A
Sbjct: 64  KPREGVAPELLTEDAFALIEREDVDIVVEVIGGIEYPREVVLAALKAGKSVVTANKALVA 123

Query: 121 NHYDELITLARENGVGIFFESTVMAGTPIIGLLRENLLGEEIVKMEAIVNASTTFILTRM 180
            H  EL   A    V ++FE+ V    P++G LR +L G++I  +  IVN +T FIL  M
Sbjct: 124 AHSAELADAAEAANVDLYFEAAVAGAIPVVGPLRRSLAGDQIQSVMGIVNGTTNFILDAM 183

Query: 181 EN-GKTFEEAMEEARTLGILEEDPSKDIDGIDAYYKAKILHWVSYGEQPEEEE--REGIR 237
           ++ G  + +++ EA  LG  E DP+ D++G DA  KA IL  +++  +   ++   EGI 
Sbjct: 184 DSTGADYADSLAEATRLGYAEADPTADVEGHDAASKAAILASIAFHTRVTADDVYCEGIS 243

Query: 238 NVKDA---------RNVRLVA-------EISKGRIS--VAPRKLPDNSPLL-VSEVENAA 278
           N+  A           ++L+A       +  K  IS  V P  LP + PL  V++  NA 
Sbjct: 244 NISAADIEAAQQAGHTIKLLAICEKFTNKEGKSAISARVHPTLLPVSHPLASVNKSFNAI 303

Query: 279 LIKTENL-TLTLKGPGGGGKVTASGVFTDIIKAA 311
            ++ E    L   G G GG  TAS V  D++ AA
Sbjct: 304 FVEAEAAGRLMFYGNGAGGAPTASAVLGDVVGAA 337


>dbj|BAB04972.1| (AP001511) homoserine dehydrogenase [Bacillus halodurans]
           Length = 417
           
 Score =  114 bits (282), Expect = 2e-24
 Identities = 90/327 (27%), Positives = 159/327 (48%), Gaps = 42/327 (12%)

Query: 3   VKVSVFGFGTVGRALAEIIAEKRKVFGVE--LNVVSITDRSGTIWGDFDLLEAKEVKEST 60
           +KV V GFGTVG+ + E + +  +    E  L ++ +T+R              E  E  
Sbjct: 2   IKVGVIGFGTVGQGVVESLVQLERGLRKEVTLEMLLVTNR-----------RKHEHSEQY 50

Query: 61  GKLSNIGEYEVYDFSPQELIEEVKPDILVDVSSWDDAHEMYSYALAEGISVVTSNKPPIA 120
             +++  ++E +     +++ E    I       +  ++   + L +G+ VVT+NK  +A
Sbjct: 51  ALVTD--DWETFAARYYDVVFEAAGGI-------EPVYDYVRFFLKKGVPVVTANKKLVA 101

Query: 121 NHYDELITLARENGVGIFFESTVMAGTPIIGLLRENLLGEEIVKMEAIVNASTTFILTRM 180
              +EL  LA EN   + +E+ V  G PI+  ++  L       +  I+N +T +ILT M
Sbjct: 102 ERGEELERLAAENDTYLCYEAAVAGGIPILNAIKGTLATTSFTSVAGILNGTTNYILTGM 161

Query: 181 -ENGKTFEEAMEEARTLGILEEDPSKDIDGIDAYYKAKILHWVSYGEQPEEEE--REGIR 237
            E  + F++ +EEA+  G  E DP+ DI+G DA+YK +IL  + +G  P  ++  R G+ 
Sbjct: 162 IEQNRPFQDMLEEAQAKGYAEADPTDDIEGYDAWYKIRILARLCFGIWPNRDDISRSGLH 221

Query: 238 NVKD-----ARNVRLVAEISKGRI---------SVAPRKLPDNSPL-LVSEVENAALIKT 282
           +V D      +++ L  ++  GR          SVAP    ++ P   V  V NA +++ 
Sbjct: 222 DVLDWHVELGQSLGLTLKLD-GRASVKNNTIIGSVAPAFFTNDHPFSTVYGVTNAVVLEG 280

Query: 283 ENL-TLTLKGPGGGGKVTASGVFTDII 308
           + +  L   GPG G + TA+ +  D +
Sbjct: 281 KAIERLLFTGPGAGKEATANSMVEDYL 307


>gb|AAF21129.1|L78665_3 (L78665) homoserine dehydrogenase [Methylobacillus flagellatus]
           Length = 437
           
 Score =  113 bits (279), Expect = 4e-24
 Identities = 97/330 (29%), Positives = 160/330 (48%), Gaps = 42/330 (12%)

Query: 3   VKVSVFGFGTVGRALAEIIAEKRKVF----GVELNVVSITDRSGTIWGDFDLLEAKEVKE 58
           + V + G GTVG     ++   ++      G  + +  + DR+        L  A++V  
Sbjct: 4   INVGLLGIGTVGGGTYTVLTRNQEEIARRAGRPIAITRVADRN--------LELARKV-- 53

Query: 59  STGKLSNIGEYEVYDFSPQELIEEVKPDILVD-VSSWDDAHEMYSYALAEGISVVTSNKP 117
                   G+ +V D     ++ +   DI+V+ +     A E+   A+  G  VVT+NK 
Sbjct: 54  ------TAGQVDVTD-DAFAVVADPSIDIVVELIGGCTVARELVMKAIEHGKHVVTANKG 106

Query: 118 PIANHYDELITLARENGVGIFFESTVMAGTPIIGLLRENLLGEEIVKMEAIVNASTTFIL 177
            IA H +E+   A++ GV + FE+ V  G PII  +RE L    I  +  I+N +T FIL
Sbjct: 107 LIALHGNEIFAAAQQKGVIVAFEAAVAGGIPIIKAVREGLAANRIEWIAGIINGTTNFIL 166

Query: 178 TRM-ENGKTFEEAMEEARTLGILEEDPSKDIDGIDAYYKAKILHWVSYG--EQPEEEERE 234
           + M E    F + ++EA+ LG  E DP+ D++G+DA +K  IL  + +G   Q ++   E
Sbjct: 167 SEMREKALAFADVLKEAQRLGYAEADPTFDVEGVDAAHKLMILAAIGFGIPMQFDKAYVE 226

Query: 235 GIRNVKDARNVRLVAEI-------------SKG-RISVAPRKLPDNSPLL-VSEVENAAL 279
           GI  + D+ ++R   E+             S+G  + V P  +P+   +  V+   NA L
Sbjct: 227 GISKL-DSIDIRYAEELGYRVKLLGITKRTSQGVELRVHPTLIPEKRLIANVNGAMNAVL 285

Query: 280 IKTENLTLTL-KGPGGGGKVTASGVFTDII 308
           +K + +  TL  G G G + TAS V  DI+
Sbjct: 286 VKGDAVGPTLYYGAGAGAEPTASAVVADIV 315


>sp|Q9ZL20|DHOM_HELPJ HOMOSERINE DEHYDROGENASE (HDH) >gi|7431118|pir||C71893 homoserine
           dehydrogenase - Helicobacter pylori (strain J99)
           >gi|4155323|gb|AAD06338.1| (AE001506) HOMOSERINE
           DEHYDROGENASE [Helicobacter pylori J99]
           Length = 421
           
 Score =  111 bits (275), Expect = 1e-23
 Identities = 97/335 (28%), Positives = 171/335 (50%), Gaps = 45/335 (13%)

Query: 2   KVKVSVFGFGTVGRALAEIIAEKRKVFGVELNVVSITDRSGTIWGDFDLLEAKEVKESTG 61
           ++ + + G G VG  +A+I+ E +++         I DR+G            E+K    
Sbjct: 4   RLNIGLVGLGCVGSTVAKILQENQEI---------IKDRAGV-----------EIKIKKA 43

Query: 62  KLSNIGEYEVYDFSPQE----LIEEVKPDILVDVSSWDDA-HEMYSYALAEGISVVTSNK 116
            + ++ +++ Y F   +    +IE+   DI+V++    +A + +    LA+  + VT+NK
Sbjct: 44  VVRDVKKHKGYAFEISDDLESVIEDKGIDIVVELMGGVEAPYLLAKKTLAKQKAFVTANK 103

Query: 117 PPIANHYDELITLARENGVGIFFESTVMAGTPIIGLLRENLLGEEIVKMEAIVNASTTFI 176
             +A H  EL  +A+   +G  FE++V  G PII  L++ L    I+  + I+N ++ +I
Sbjct: 104 AMLAYHRYELEQIAKNTPIG--FEASVCGGIPIIKALKDGLSANHILSFKGILNGTSNYI 161

Query: 177 LTRM-ENGKTFEEAMEEARTLGILEEDPSKDIDGIDAYYKAKILHWVSYGEQPEEEE--R 233
           L++M +N  +F++A+++A+ LG  E +P  DI GIDA +K  IL  ++YG   + EE   
Sbjct: 162 LSQMFKNQASFKDALKDAQHLGYAELNPEFDIKGIDAAHKLLILASLAYGIDAKLEEILI 221

Query: 234 EGIRNVKD---------ARNVRLVAEISKGRISVAPRKLPD---NSPLL--VSEVENAAL 279
           EGI  ++            +++L+    K +  +  R  P    N  +L  V  V NA  
Sbjct: 222 EGIEKIEPDDMEFAKEFGYSIKLLGIAKKHQDCIELRVHPSMIKNECMLSKVDGVMNAIS 281

Query: 280 IKTENLTLTL-KGPGGGGKVTASGVFTDIIKAALK 313
           +  + +  TL  G G GG+ TAS V +DII+ A K
Sbjct: 282 VIGDKVGETLYYGAGAGGEPTASAVISDIIEIARK 316


>sp|P52986|DHOM_SYNY3 HOMOSERINE DEHYDROGENASE (HDH) >gi|7431117|pir||S74407 homoserine
           dehydrogenase (EC 1.1.1.3) - Synechocystis sp.  (strain
           PCC 6803) >gi|1001182|dbj|BAA10325.1| (D64001)
           homoserine dehydrogenase [Synechocystis sp.]
           Length = 433
           
 Score =  111 bits (274), Expect = 1e-23
 Identities = 99/338 (29%), Positives = 160/338 (47%), Gaps = 52/338 (15%)

Query: 1   MKVKVSVFGFGTVGRALAEIIAEKRKVFGVELNVVSITDRSGTIWGDFDLLEAKEVKEST 60
           M VK+ + G GTVG    EI+ + +                    G   LL+A EVK + 
Sbjct: 1   MTVKIGLLGLGTVGSGTVEILQDPQ--------------------GRSPLLKAIEVK-AV 39

Query: 61  GKLSNIGEYEVYDFSPQELIEEVK-----PDILVDVS---SWDDAHEMYSYALAEGISVV 112
           G + ++ +    +  P+ L  +++     PDI + V      + A  +   A+A    +V
Sbjct: 40  G-VRSLDKPRQVNLPPEVLTTDLEAIVTDPDIAIVVELMGGLEPARSLILQAIAHKKHIV 98

Query: 113 TSNKPPIANHYDELITLARENGVGIFFESTVMAGTPIIGLLRENLLGEEIVKMEAIVNAS 172
           T+NK  IA +  E+   A ++GV +  E+ V  G PII  L+++L G  I  +  I+N +
Sbjct: 99  TANKAVIARYGPEIYEAANQHGVYVLLEAAVGGGIPIIKPLKQSLGGNRIQSIVGILNGT 158

Query: 173 TTFILTRM-ENGKTFEEAMEEARTLGILEEDPSKDIDGIDAYYKAKILHWVSYGEQPEEE 231
           T +IL+RM   G  F+E +  A+ LG  E DPS D+DG+DA  K  IL  + +G + + E
Sbjct: 159 TNYILSRMTSEGADFDEVLTAAQQLGYAEADPSADVDGLDAADKIAILASLGFGGRVKRE 218

Query: 232 E--REGIRNVKDAR-----------NVRLVAEISKG------RISVAPRKLPDNSPLL-V 271
           +   EGIR+V                +  +A+ + G      ++ V P  +  + PL  V
Sbjct: 219 DVACEGIRSVSAVDIAYADRLGFVIKLLAIADGNAGEDSEALQLRVHPTLIAKDHPLASV 278

Query: 272 SEVENAALIKTENL-TLTLKGPGGGGKVTASGVFTDII 308
           + V N  L+  + L  +   G G G   TAS V +D+I
Sbjct: 279 NGVYNGVLVTGDPLGQVMFYGRGAGAGPTASAVVSDVI 316


>sp|P56429|DHOM_HELPY HOMOSERINE DEHYDROGENASE (HDH) >gi|7431119|pir||F64622 homoserine
           dehydrogenase (EC 1.1.1.3) - Helicobacter pylori
           (strain 26695) >gi|2313952|gb|AAD07869.1| (AE000593)
           homoserine dehydrogenase (metL) [Helicobacter pylori
           26695]
           Length = 421
           
 Score =  111 bits (274), Expect = 1e-23
 Identities = 99/331 (29%), Positives = 168/331 (49%), Gaps = 37/331 (11%)

Query: 2   KVKVSVFGFGTVGRALAEIIAEKRKVFGVELNVVSITDRSGTIWGDFDLLEAKEVKESTG 61
           ++ + + G G VG A+A+I+ E +++         I DR+G   G       ++VK+  G
Sbjct: 4   RLNIGLVGLGCVGSAVAKILQENQEI---------IKDRAGVGIG-IKKAVVRDVKKHKG 53

Query: 62  KLSNIGEYEVYDFSPQELIEEVKPDILVDVSSWDDA-HEMYSYALAEGISVVTSNKPPIA 120
               I          + LIE+ + DI+V++    +A + +    LA+  + VT+NK  +A
Sbjct: 54  YPFEISN------DLESLIEDEEIDIVVELMGGVEAPYLLAKKTLAKQKAFVTANKAMLA 107

Query: 121 NHYDELITLARENGVGIFFESTVMAGTPIIGLLRENLLGEEIVKMEAIVNASTTFILTRM 180
            H  EL   A+   +G  FE++V  G PII  L++ L    I+  + I+N ++ +IL++M
Sbjct: 108 YHRYELEQTAKNTPIG--FEASVCGGIPIIKALKDGLSANHILSFKGILNGTSNYILSQM 165

Query: 181 -ENGKTFEEAMEEARTLGILEEDPSKDIDGIDAYYKAKILHWVSYGEQPEEEE--REGIR 237
            +N  +F++A+++A+ LG  E +P  DI GIDA +K  IL  ++YG   + EE   EGI 
Sbjct: 166 FKNQASFKDALKDAQHLGYAELNPEFDIKGIDAAHKLLILASLAYGIDAKLEEILIEGIE 225

Query: 238 NVKD---------ARNVRLVAEISKG----RISVAPRKLPDNSPL-LVSEVENAALIKTE 283
            ++            +++L+    K      + V P  + +   L  V  V NA  +  +
Sbjct: 226 KIEPDDMEFAKEFGYSIKLLGIAKKHPDCIELRVHPSMIKNECMLSKVDGVMNAISVIGD 285

Query: 284 NLTLTL-KGPGGGGKVTASGVFTDIIKAALK 313
            +  TL  G G GG+ TAS V +DII+ A K
Sbjct: 286 KVGETLYYGAGAGGEPTASAVISDIIEIARK 316


>gb|AAG20683.1| (AE005137) homoserine dehydrogenase; Hom [Halobacterium sp. NRC-1]
           Length = 317
           
 Score =  109 bits (271), Expect = 3e-23
 Identities = 87/320 (27%), Positives = 144/320 (44%), Gaps = 25/320 (7%)

Query: 3   VKVSVFGFGTVGRALAEIIAEKRKVFGVELNVVSITDRSGTIWGDFDLLEAKEVKESTGK 62
           ++++V G G VG+A+ +  A           VV++ D +  +     +  A         
Sbjct: 1   MRLAVMGAGAVGQAVVDQAASHGHT------VVAVADSTSAVVDGSGVDAAAVCARKRDA 54

Query: 63  LSNIGEYEVYDF--SPQELIEEVKPDILVDVSSWDDAHEMYSYALAEGISVVTSNKPPIA 120
            S IG     D   +  +++ E  P  L D    +        AL+    VV +NK P+A
Sbjct: 55  ASEIGTGAPSDALAADYDVLVEATPTTLGDA---EPGFGHVERALSADRHVVLANKGPVA 111

Query: 121 NHYDELITLARENGVGIFFESTVMAGTPIIGLLRENLLGEEIVKMEAIVNASTTFILTRM 180
             Y  +  LA  +   + FE+TV    P++  + E +  + +  +  ++N +  F+L+RM
Sbjct: 112 ERYAGVCELAAASAGSLRFEATVGGAIPVLATI-ERIGADRVRAVRGVLNGTANFVLSRM 170

Query: 181 EN-GKTFEEAMEEARTLGILEEDPSKDIDGIDAYYKAKILHWVSYGEQPEEE--EREGIR 237
              G  +E  + EA+ +G+ E DP+ D+DG DA  K  IL  V    + + +    +GI 
Sbjct: 171 AAAGLEYEHVLAEAQEVGVAEADPTFDVDGTDAALKCAILANVIGDREYDLDGVSVDGIT 230

Query: 238 NV---------KDARNVRLVAEISKGRISVAPRKLPDNSPLLVSEVENAALIKTENL-TL 287
            V          D + +RL+ E+    + V PR +P N  L VS   N   ++TE+   L
Sbjct: 231 GVAPSALELAETDGQTIRLIGEVGPDHVRVGPRLVPANGTLAVSGTTNIVQLETEHAGRL 290

Query: 288 TLKGPGGGGKVTASGVFTDI 307
            L G G GG  TAS V  D+
Sbjct: 291 NLSGQGAGGAATASAVLADV 310


>pir||E81106 probable homoserine dehydrogenase (EC 1.1.1.3) NMA1395 [imported] -
           Neisseria meningitidis (group B strain MD58, group A
           strain Z2491) >gi|7226467|gb|AAF41609.1| (AE002471)
           homoserine dehydrogenase [Neisseria meningitidis MC58]
           >gi|7380055|emb|CAB84636.1| (AL162755) putative
           homoserine dehydrogenase [Neisseria meningitidis Z2491]
           Length = 435
           
 Score =  109 bits (271), Expect = 3e-23
 Identities = 95/333 (28%), Positives = 156/333 (46%), Gaps = 43/333 (12%)

Query: 3   VKVSVFGFGTVGRALAEIIAEKRKVF----GVELNVVSITDRSGTIWGDFDLLEAKEVKE 58
           V + + G GTVG   A ++ +  +      G E+ + ++ D S          +A++   
Sbjct: 4   VNIGLLGLGTVGGGTAAVLRDNAEEISRRLGREIRISAVCDLSEE--------KARQTCP 55

Query: 59  STGKLSNIGEYEVYDFSPQELIEEVKPDILVDVSSWDD-AHEMYSYALAEGISVVTSNKP 117
           S   + +          P EL+     D++V++      A +    A+  G  +VT+NK 
Sbjct: 56  SAAFVKD----------PFELVAREDVDVVVELFGGTGIAKDAVLKAIENGKHIVTANKK 105

Query: 118 PIANHYDELITLARENGVGIFFESTVMAGTPIIGLLRENLLGEEIVKMEAIVNASTTFIL 177
            +A + +E+  LA +  V + FE+ V  G PII  LRE L    I  +  I+N ++ FIL
Sbjct: 106 LLAEYGNEIFPLAEKQNVIVQFEAAVAGGIPIIKALREGLAANRIKSIAGIINGTSNFIL 165

Query: 178 TRM-ENGKTFEEAMEEARTLGILEEDPSKDIDGIDAYYKAKILHWVSYGEQPEEEE--RE 234
           + M E G  F + ++EA+ LG  E DP+ DI+G DA +K  I+  +++G          E
Sbjct: 166 SEMREKGSAFADVLKEAQALGYAEADPTFDIEGNDAGHKITIMSALAFGTPMNFSACYLE 225

Query: 235 GIRNVKDARNVRLVAEI-------------SKG-RISVAPRKLPDNSPLL-VSEVENAAL 279
           GI  + D+R+++   E+              KG  + V P  +P++  L  V+ V NA  
Sbjct: 226 GISKL-DSRDIKYAEELGYRIKLLGITRKTGKGIELRVHPTLIPESRLLANVNGVMNAVR 284

Query: 280 IKTENLTLTL-KGPGGGGKVTASGVFTDIIKAA 311
           +  + +  TL  G G G   TAS V  DII  A
Sbjct: 285 VNADMVGETLYYGAGAGALPTASAVVADIIDIA 317


>sp|P46806|DHOM_MYCLE HOMOSERINE DEHYDROGENASE (HDH) >gi|7431123|pir||T09992 aspartate
           kinase (EC 2.7.2.4) / homoserine dehydrogenase (EC
           1.1.1.3) - Mycobacterium leprae
           >gi|699340|gb|AAA63101.1| (U15186) homoserine
           dehydrogenase [Mycobacterium leprae]
           Length = 441
           
 Score =  109 bits (269), Expect = 5e-23
 Identities = 84/259 (32%), Positives = 132/259 (50%), Gaps = 24/259 (9%)

Query: 77  QELIEEVKPDILVDVSSWDD-AHEMYSYALAEGISVVTSNKPPIANHYDELITLARENGV 135
           +EL+     DI+V+V    + + +    AL  G SVVT+NK  +A    EL   A    V
Sbjct: 67  EELVSRADVDIVVEVMGPVELSRKAILSALEHGKSVVTANKALLAASTGELAQAAESAHV 126

Query: 136 GIFFESTVMAGTPIIGLLRENLLGEEIVKMEAIVNASTTFILTRMEN-GKTFEEAMEEAR 194
            ++FE+ V    P+I  L ++L G+ ++++  IVN +T +IL+ M++ G  ++ A+  AR
Sbjct: 127 DLYFEAAVAGAIPVIRPLTQSLAGDTVLRVAGIVNGTTNYILSAMDSTGADYDSALAGAR 186

Query: 195 TLGILEEDPSKDIDGIDAYYKAKILHWVSYGEQPEEEE--REGIRNVKDARNV------- 245
            LG  E DP+ D++G DA  KA IL  +++  +   ++  REGI  +  A  V       
Sbjct: 187 ALGYAEADPTADVEGHDAAAKAAILASIAFHTRVTADDVYREGITKITPADFVSARALGC 246

Query: 246 ---------RLVAEISKGRIS--VAPRKLPDNSPL-LVSEVENAALIKTENL-TLTLKGP 292
                    R+ A   + R+S  V P  +P + PL  VS   NA +++ E    L   G 
Sbjct: 247 TIKLLFICERITAADGQQRVSARVYPALVPMSHPLATVSGAFNAVVVEAEAAGRLMFYGQ 306

Query: 293 GGGGKVTASGVFTDIIKAA 311
           G GG  TAS V  D++ AA
Sbjct: 307 GAGGAPTASAVTGDLVMAA 325


>gb|AAD32592.1|AF126720_3 (AF126720) homoserine dehydrogenase [Mycobacterium smegmatis]
           Length = 373
           
 Score =  108 bits (268), Expect = 7e-23
 Identities = 98/335 (29%), Positives = 158/335 (46%), Gaps = 43/335 (12%)

Query: 3   VKVSVFGFGTVGRALAEIIAEKRKVFGVELNVVSITDRSGTIWGDFDL--LEAKEVKEST 60
           + V+V G G VG  +  IIA+            S  D +  I    +L  +  + V +  
Sbjct: 6   IGVAVLGLGNVGSEVVRIIAD------------SADDLAARIGAPLELRGVGVRRVADDR 53

Query: 61  GKLSNIGEYEVYDFSPQELIEEVKPDILVDVSS-WDDAHEMYSYALAEGISVVTSNKPPI 119
           G  + +   ++       L+     DI+V+V    + A +    AL +G SVVT+NK  +
Sbjct: 54  GVPTELLTDDI-----DALVSRDDVDIVVEVMGPVEPARKAILSALEQGKSVVTANKALM 108

Query: 120 ANHYDELITLARENGVGIFFESTVMAGTPIIGLLRENLLGEEIVKMEAIVNASTTFILTR 179
           A    EL   A +  V ++FE+ V    P+I  L ++L G+ + ++  IVN +T +IL+ 
Sbjct: 109 AMSTGELAQAAEKAHVDLYFEAAVAGAIPVIRPLTQSLAGDTVRRVAGIVNGTTNYILSE 168

Query: 180 MEN-GKTFEEAMEEARTLGILEEDPSKDIDGIDAYYKAKILHWVSYGEQPEEEE--REGI 236
           M++ G  +  A+ +A  LG  E DP+ D++G DA  KA IL  +++  +   ++  REGI
Sbjct: 169 MDSTGADYTSALADASALGYAEADPTADVEGYDAAAKAAILASIAFHTRVTADDVYREGI 228

Query: 237 RNVK-----DARNV-----------RLVAEISKGRIS--VAPRKLPDNSPL-LVSEVENA 277
             V       AR +           RL ++  K R+S  V P  +P   PL  V+   NA
Sbjct: 229 TTVSAEDFASARALGCTIKLLAICERLTSDEGKDRVSARVYPALVPLTHPLAAVNGAFNA 288

Query: 278 ALIKTENL-TLTLKGPGGGGKVTASGVFTDIIKAA 311
            +++ E    L   G G GG  TA  V  D++ AA
Sbjct: 289 VVVEAEAAGRLMFYGQGAGGAPTAFAVMGDVVMAA 323


>pir||A72716 probable homoserine dehydrogenase APE1144 - Aeropyrum pernix
           (strain K1) >gi|5104814|dbj|BAA80129.1| (AP000060) 334aa
           long hypothetical homoserine dehydrogenase [Aeropyrum
           pernix]
           Length = 334
           
 Score =  106 bits (262), Expect = 4e-22
 Identities = 100/329 (30%), Positives = 153/329 (46%), Gaps = 32/329 (9%)

Query: 1   MKVKVSVFGFGTVGRALAEIIAEKRKVFGVELNVVSITDRSGTIWGDFDLLEAKEVKEST 60
           M V+V+V GFG VGR LA ++ E+    G+ L   +I  R   +   FD     E   S 
Sbjct: 1   MAVRVAVAGFGGVGRRLARLLLERGGSHGLSL-AAAIDSRGHAV---FDSRGCVEEALSA 56

Query: 61  GKLSNIGEYEVYDFSPQELIEEVKPD--ILVDVSSWDDAHEMYSY---ALAEGISVVTSN 115
            +    G       S   ++  +  D  +L   SS         Y   AL +G  VV ++
Sbjct: 57  PRGGLAGVSCGAPGSGPGVLRGLGYDALVLTTASSPGTGEPGLGYARAALEDGKVVVAAD 116

Query: 116 KPPIANHYDELITLARENG---VGIFFESTVMAGTPIIGLLRENLLGEEIVKMEAIVNAS 172
           KPP+A        L  E+G    G+F+++TVMAGTP+I LLR  L G  ++++  ++N +
Sbjct: 117 KPPVA-------LLLLEHGGPPPGLFYKATVMAGTPLIDLLRVGLAGRRVLRVVGVLNGT 169

Query: 173 TTFILTRMENGKTFEEAMEEARTLGILEEDPSKDIDGIDAYYKAKILHW-----VSYGE- 226
           + +IL  +  G   EEA+E A  LGI E DPS D+ G+D   KA I+       V  G+ 
Sbjct: 170 SNYILNLLMEGVPLEEAVEAAVRLGIAEPDPSADLRGVDLALKASIVAQTLGCPVGPGDV 229

Query: 227 ------QPEEEEREGIRNVKDARNVRLVAEISKGRISVAPRKLPDNSPLL-VSEVENAAL 279
                         G+R    A       +++  R  +        S L  +    NAA+
Sbjct: 230 VVGGTVYDAAGWAPGLRGAGAALRYTARVDVAGCRAEIGLTLHGAGSRLYSLPGSLNAAV 289

Query: 280 IKTENLTLTLKGPGGGGKVTASGVFTDII 308
           I  E+ T+ L+GPG G  VTA+ + +D++
Sbjct: 290 IGLEDSTIYLEGPGAGLGVTAATLLSDLV 318


>emb|CAC12304.1| (AL445066) homoserine dehydrogenase related protein [Thermoplasma
           acidophilum]
           Length = 324
           
 Score =  106 bits (262), Expect = 4e-22
 Identities = 76/259 (29%), Positives = 137/259 (52%), Gaps = 16/259 (6%)

Query: 2   KVKVSVFGFGTVGRALAEII-AEKRKVFGVELNVVSITD-RSGTIWGDFDLLEAKEVKES 59
           ++++ + G G VG  +  II A  R+     + VV ++D RS     + D+      KE 
Sbjct: 3   EIRIILMGTGNVGLNVLRIIDASNRRRSAFSIKVVGVSDSRSYASGRNLDISSIISNKEK 62

Query: 60  TGKLSNIGEYEVYDFS-PQELIEEVKPDILVDVS--SWDDAHE--MYSYALAEGISVVTS 114
           TG++S+        FS P++L+ E   D+LVD +  S D   E  +Y  A   G++VVT+
Sbjct: 63  TGRISDRA------FSGPEDLMGEAA-DLLVDCTPASRDGVREYSLYRMAFESGMNVVTA 115

Query: 115 NKPPIANHYDELITLARENGVGIFFESTVMAGTPIIGLLRENLLGEEIVKMEAIVNASTT 174
           NK  +AN + +++  A +N   I +E+TV  G P+  +L  ++L  ++ +   IV+++  
Sbjct: 116 NKSGLANKWHDIMDSANQNSKYIRYEATVAGGVPLFSVLDYSILPSKVKRFRGIVSSTIN 175

Query: 175 FILTRMENGKTFEEAMEEARTLGILEEDPSKDIDGIDAYYKAKILHWVSYGEQ--PEEEE 232
           +++  M NG++  + +++A   GI E +P  D++G+DA  K+ IL    +G +    + E
Sbjct: 176 YVIRNMANGRSLRDVVDDAIKKGIAESNPQDDLNGLDAARKSVILVNHIFGTEYTLNDVE 235

Query: 233 REGIRNVKDARNVRLVAEI 251
             G+       N RLV E+
Sbjct: 236 YSGVDERSYNANDRLVTEV 254


>pir||T06246 aspartate kinase (EC 2.7.2.4) / homoserine dehydrogenase (EC
           1.1.1.3) precursor - soybean (fragment)
           >gi|2970556|gb|AAC05983.1| (AF049708)
           aspartokinase-homoserine dehydrogenase [Glycine max]
           Length = 909
           
 Score =  105 bits (260), Expect = 6e-22
 Identities = 92/357 (25%), Positives = 166/357 (45%), Gaps = 53/357 (14%)

Query: 3   VKVSVFGFGTVGRALAEIIAEK----RKVFGVELNVVSITDRSGTIWGD--FDLLEAKEV 56
           + + + G G +G  L + + ++    ++ F ++L V+ I      +  D   DL   +E+
Sbjct: 558 IAMGIIGPGLIGSTLLDQLRDQASTLKEEFNIDLRVMGILGSKSMLLSDVGIDLARWREL 617

Query: 57  KESTGKLSNIGEYEVYDFSPQELIEEVKPDILVDVSSWDDAHEMYSYA-LAEGISVVTSN 115
           +E  G+++N+ ++ V        I       LVD ++ D A   Y Y  L +GI VVT N
Sbjct: 618 REERGEVANVEKF-VQHVHGNHFIPNTA---LVDCTA-DSAIAGYYYDWLRKGIHVVTPN 672

Query: 116 KPPIANHYDELI---TLARENGVGIFFESTVMAGTPIIGLLRENL-LGEEIVKMEAIVNA 171
           K   +   D+ +    L R++    F+E+TV AG PI+  LR  L  G++I+++E I + 
Sbjct: 673 KKANSGPLDQYLKLRALQRQSYTHYFYEATVGAGLPIVSTLRGLLETGDKILQIEGIFSG 732

Query: 172 STTFILTRMENGKTFEEAMEEARTLGILEEDPSKDIDGIDAYYKAKILHWVS-------- 223
           + ++I    ++G+ F E + EA+  G  E DP  D+ G D   K  IL   S        
Sbjct: 733 TLSYIFNNFKDGRAFSEVVSEAKEAGYTEPDPRDDLSGTDVARKVIILARESGLKLELSN 792

Query: 224 -------------------YGEQPEEEEREGIRNVKDARNVRL------VAEISKGRISV 258
                              + ++P + ++E  +  +DA N         V +++  +  V
Sbjct: 793 IPVESLVPEPLRACASAQEFMQEPPKFDQEFTKKQEDAENAGEVLRYVGVVDVTNEKGVV 852

Query: 259 APRKLPDNSPLL-VSEVENAALIKT---ENLTLTLKGPGGGGKVTASGVFTDIIKAA 311
             R+   + P   +S  +N     T   ++  L ++GPG G +VTA G+F+DI++ A
Sbjct: 853 ELRRYKKDHPFAQLSGSDNIIAFTTRRYKDQPLIVRGPGAGAQVTAGGIFSDILRLA 909


>sp|Q10601|DHOM_MYCTU HOMOSERINE DEHYDROGENASE (HDH) >gi|7431115|pir||B70773 probable
           thrA protein - Mycobacterium tuberculosis (strain H37RV)
           >gi|1322418|emb|CAA97759.1| (Z73419) thrA [Mycobacterium
           tuberculosis]
           Length = 441
           
 Score =  104 bits (257), Expect = 1e-21
 Identities = 94/333 (28%), Positives = 149/333 (44%), Gaps = 39/333 (11%)

Query: 3   VKVSVFGFGTVGRALAEIIAEKRKVFGVELNVVSITDRSGTIWGDFDLLEAKEVKESTGK 62
           V V+V G G VG  +  II    +     +    +    G           + V    G 
Sbjct: 8   VGVAVLGLGNVGSEVVRIIENSAEDLAARVGAPLVLRGIGV----------RRVTTDRGV 57

Query: 63  LSNIGEYEVYDFSPQELIEEVKPDILVDVSS-WDDAHEMYSYALAEGISVVTSNKPPIAN 121
                  E+     +EL+     DI+V+V    + + +    AL  G SVVT+NK  +A 
Sbjct: 58  -----PIELLTDDIEELVAREDVDIVVEVMGPVEPSRKAILGALERGKSVVTANKALLAT 112

Query: 122 HYDELITLARENGVGIFFESTVMAGTPIIGLLRENLLGEEIVKMEAIVNASTTFILTRME 181
              EL   A    V ++FE+ V    P+I  L ++L G+ ++++  IVN +T +IL+ M+
Sbjct: 113 STGELAQAAESAHVDLYFEAAVAGAIPVIRPLTQSLAGDTVLRVAGIVNGTTNYILSAMD 172

Query: 182 N-GKTFEEAMEEARTLGILEEDPSKDIDGIDAYYKAKILHWVSYGEQPEEEE--REGIRN 238
           + G  +  A+ +A  LG  E DP+ D++G DA  KA IL  +++  +   ++  REGI  
Sbjct: 173 STGADYASALADASALGYAEADPTADVEGYDAAAKAAILASIAFHTRVTADDVYREGITK 232

Query: 239 VKDAR----------------NVRLVAEISKGRIS--VAPRKLPDNSPL-LVSEVENAAL 279
           V  A                   R+  +    R+S  V P  +P + PL  V+   NA +
Sbjct: 233 VTPADFGSAHALGCTIKLLSICERITTDEGSQRVSARVYPALVPLSHPLAAVNGAFNAVV 292

Query: 280 IKTENL-TLTLKGPGGGGKVTASGVFTDIIKAA 311
           ++ E    L   G G GG  TAS V  D++ AA
Sbjct: 293 VEAEAAGRLMFYGQGAGGAPTASAVTGDLVMAA 325


>pir||T06242 aspartate kinase (EC 2.7.2.4) / homoserine dehydrogenase (EC
           1.1.1.3) precursor - soybean chloroplast
           >gi|2970447|gb|AAC05981.1| (AF049706)
           aspartokinase-homoserine dehydrogenase [Glycine max]
           Length = 916
           
 Score =  102 bits (252), Expect = 5e-21
 Identities = 90/366 (24%), Positives = 166/366 (44%), Gaps = 59/366 (16%)

Query: 3   VKVSVFGFGTVGRALAEIIAEK----RKVFGVELNVVSITDRSGTIWGD--FDLLEAKEV 56
           + + + G G +G  L E + ++    ++ F ++L V+ I      +  D   DL   +E+
Sbjct: 558 IAMGIIGPGLIGSTLLEQLRDQASTLKEEFNIDLRVMGILGSKSMLLSDVGIDLARWREL 617

Query: 57  KESTGKLSNIGEYEVY----DFSPQELIEEVKPDILVDVSSWDDAHEMYSYALAEGISVV 112
           +E  G+++N+ ++  +     F P   + +   D ++       A   Y + L +GI VV
Sbjct: 618 REERGEVANMEKFVQHVHGNHFIPNTALVDCTADSVI-------AGYYYDW-LRKGIHVV 669

Query: 113 TSNKPPIANHYDELI---TLARENGVGIFFESTVMAGTPIIGLLRENL-LGEEIVKMEAI 168
           T NK   +   D+ +    L R++    F+E+TV AG PI+  LR  L  G++I+++E I
Sbjct: 670 TPNKKANSGPLDQYLKLRALQRQSYTHYFYEATVGAGLPIVSTLRGLLETGDKILQIEGI 729

Query: 169 VNASTTFILTRMENGKTFEEAMEEARTLGILEEDPSKDIDGIDAYYKAKILHWVS----- 223
            + + ++I    ++G+ F E + EA+  G  E DP  D+ G D   K  IL   S     
Sbjct: 730 FSGTLSYIFNNFKDGRAFSEVVSEAKEAGYTEPDPRDDLSGTDVARKVIILARESGLKLE 789

Query: 224 ----------------------YGEQPEEEEREGIRNVKDARN-------VRLVAEISKG 254
                                 + ++  + ++E  +  +DA N       V +V   +K 
Sbjct: 790 LSNIPVESPVPEPLRACASAQEFMQELPKFDQEFTKKQEDAENAGEVLRYVGVVDVTNKK 849

Query: 255 RISVAPRKLPDNSPLLVSEVENAALIKT---ENLTLTLKGPGGGGKVTASGVFTDIIKAA 311
            +    R   D+    +S  +N     T   ++  L ++GPG G +VTA G+F+DI++ A
Sbjct: 850 GVVELRRYKKDHPFAQLSGSDNIIAFTTRRYKDQPLIVRGPGAGAQVTAGGIFSDILRLA 909

Query: 312 LKFPSP 317
               +P
Sbjct: 910 SYLGAP 915


>pir||E81432 homoserine dehydrogenase (EC 1.1.1.3) Cj0149c [imported] -
           Campylobacter jejuni (strain NCTC 11168)
           >gi|6967643|emb|CAB72633.1| (AL139074) homoserine
           dehydrogenase [Campylobacter jejuni]
           Length = 415
           
 Score =  101 bits (249), Expect = 1e-20
 Identities = 93/328 (28%), Positives = 162/328 (49%), Gaps = 40/328 (12%)

Query: 3   VKVSVFGFGTVGRALAEIIAEKRKVFGVELNVVSITDRSGTIWGDFDLLEAKEVKESTGK 62
           +KV++ G+GTVG A+ + + E  K+         I  R G        L     K +   
Sbjct: 1   MKVAILGYGTVGSAVVKFLLENDKL---------IRARCGQSITPVIALARSPKKNALIP 51

Query: 63  LSNIGEYEVYDFSPQELIEEVKPDILVDVSSW-DDAHEMYSYALAEGISVVTSNKPPIAN 121
           +++         S  E++     D+ V++    D+A ++ S  L +  +VVT+NK  +A 
Sbjct: 52  ITH---------SVAEILN-ADVDVFVELMGGVDEAFKIVSEILKKKKAVVTANKAMLAY 101

Query: 122 HYDELITLARENGVGIFFESTVMAGTPIIGLLRENLLGEEIVKMEAIVNASTTFILTRM- 180
           H  EL  LA+    G  +E++V  G PII +L+E L    I+ ++ I+N ++ +IL+ M 
Sbjct: 102 HRYELENLAKNLAFG--YEASVAGGIPIIKVLKEGLSANNILAIKGILNGTSNYILSSMS 159

Query: 181 ENGKTFEEAMEEARTLGILEEDPSKDIDGIDAYYKAKILHWVSYG--EQPEEEEREGIRN 238
           +   +F++A++ A+ LG  E DP+ DI+G DA +K  +L  ++Y    +PE+   EGI  
Sbjct: 160 QKNMSFKQALQIAQNLGYAEADPTFDIEGQDAAHKLLVLSSIAYNLKAKPEDILIEGISE 219

Query: 239 VKDAR---------NVRL--VAEISKGRIS--VAPRKLPDNSPLL-VSEVENAALIKTEN 284
           +              ++L  +A++ + ++   V P  +     L  V  V NA  I  + 
Sbjct: 220 IAPEDMYFANEFEFTIKLLGIAKVRENKVELRVHPTMIDKEKMLAKVDGVMNAISINGDL 279

Query: 285 LTLTL-KGPGGGGKVTASGVFTDIIKAA 311
           L  +L  G G GG+ TAS V +D++  A
Sbjct: 280 LGESLYYGAGAGGEATASAVISDLMDIA 307


>pir||S46497 aspartate kinase (EC 2.7.2.4) / homoserine dehydrogenase (EC
           1.1.1.3) precursor - Arabidopsis thaliana
           Length = 911
           
 Score =  100 bits (247), Expect = 2e-20
 Identities = 91/364 (25%), Positives = 155/364 (42%), Gaps = 59/364 (16%)

Query: 5   VSVFGFGTVGRALAEIIAEKRKV----FGVELNVVSITDRSGTIWGD--FDLLEAKEVKE 58
           V + G G +G  L + I ++  V    F ++L V+ IT  S  +  +   DL   +E+ +
Sbjct: 555 VGIIGPGLIGGTLLDQIRDQAAVLKEEFKIDLRVIGITGSSKMLMSESGIDLSRWRELMK 614

Query: 59  STGKLSNIGEYEVY----DFSPQELIEEVKPDILVDVSSWDDAHEMYSYALAEGISVVTS 114
             G+ +++ ++  Y     F P          ++VD ++  D    Y   L  GI VVT 
Sbjct: 615 EEGEKADMEKFTQYVKGNHFIPNS--------VMVDCTADADIASCYYDWLLRGIHVVTP 666

Query: 115 NKPPIANHYDELIT---LARENGVGIFFESTVMAGTPIIGLLRENL-LGEEIVKMEAIVN 170
           NK   +   D+ +    L R++    F+E+TV AG PII  LR  L  G++I+++E I +
Sbjct: 667 NKKANSGPLDQYLKIRDLQRKSYTHYFYEATVGAGLPIISTLRGLLETGDKILRIEGIFS 726

Query: 171 ASTTFILTRMENGKTFEEAMEEARTLGILEEDPSKDIDGIDAYYKAKILHWVS------- 223
            + +++       ++F E + EA+  G  E DP  D+ G D   K  IL   S       
Sbjct: 727 GTLSYLFNNFAGTRSFSEVVAEAKQAGFTEPDPRDDLSGTDVARKVTILARESGLKLDLE 786

Query: 224 ---------------------------YGEQPEEEEREGIRNVKDARNVRLVAEISKGRI 256
                                      + E+  ++  E     +  R V +V  + K   
Sbjct: 787 GLPIQNLVPKPLQACASAEEFMEKLPQFDEELSKQREEAEAAGEVLRYVGVVDAVEKKGT 846

Query: 257 SVAPRKLPDNSPLLVSEVENAALIKTENL---TLTLKGPGGGGKVTASGVFTDIIKAALK 313
               R   D+    +S  +N     T+      L ++GPG G +VTA G+F+DI++ A  
Sbjct: 847 VELKRYKKDHPFAQLSGADNIIAFTTKRYKEQPLIVRGPGAGAQVTAGGIFSDILRLAFY 906

Query: 314 FPSP 317
             +P
Sbjct: 907 LGAP 910


>pir||H82086 aspartokinase I/homoserine dehydrogenase, threonine-sensitive
           VC2364 [imported] - Vibrio cholerae  (group O1 strain
           N16961) >gi|9656933|gb|AAF95507.1| (AE004306)
           aspartokinase I/homoserine dehydrogenase,
           threonine-sensitive [Vibrio cholerae]
           Length = 825
           
 Score =  100 bits (247), Expect = 2e-20
 Identities = 94/353 (26%), Positives = 163/353 (45%), Gaps = 57/353 (16%)

Query: 5   VSVFGFGTVGRALAEIIAEKRKVF---GVELNVVSITDRSGTIWGDFDLLEAKEVKESTG 61
           V V G G VG  L + I  ++      G+ + V  + +  G +     L     +++   
Sbjct: 474 VFVVGVGGVGGELVDQIQRQQAKLAEKGIMMRVCGLANSKGMLLDSQGL----PLEQWRD 529

Query: 62  KLSNIGEYEVYDFSPQELIEEVKPD-----ILVDVSSWDDAHEMYSYALAEGISVVTSNK 116
           ++ N  +     FS + L+  V+ +     +LVD +S D+    Y+  LA G  VVT NK
Sbjct: 530 RMINADQA----FSLENLVALVQRNHIINPVLVDCTSSDEIANQYADFLAAGFHVVTPNK 585

Query: 117 PPIA---NHYDELITLARENGVGIFFESTVMAGTPIIGLLRENLL--GEEIVKMEAIVNA 171
                  ++Y +L  +AR +   + +E+TV AG P+I  L +NL+  G+E+ K   I++ 
Sbjct: 586 KANTASMSYYHQLRNVARHSRRKLMYETTVGAGLPVIENL-QNLIAAGDELEKFSGILSG 644

Query: 172 STTFILTRMENGKTFEEAMEEARTLGILEEDPSKDIDGIDAYYKAKIL------------ 219
           S +FI  +++ G T  +A + A+  G  E DP  D+ G+D   K  IL            
Sbjct: 645 SLSFIFGKLDEGMTLSQATQLAKEKGFTEPDPRDDLSGMDVARKLLILAREAGYELELSD 704

Query: 220 ------------------HWVSYGEQPEEEEREGIRNVK-DARNVRLVAEISKGRISVAP 260
                              +++   Q +    E +   K + + +R VA+I  G+  V  
Sbjct: 705 VDVEQALPAGFDASGSVEEFMARLAQADAAFAERVAQAKAEGKVLRYVAQIVDGQCQVRI 764

Query: 261 RKLPDNSPLL-VSEVENAALIKT---ENLTLTLKGPGGGGKVTASGVFTDIIK 309
             + +N P+  V E ENA    +   + + L L+G G G +VTA+GVF+D+++
Sbjct: 765 VAVDENDPMFKVKEGENALAFYSRYYQPIPLVLRGYGAGSEVTAAGVFSDVMR 817


>gb|AAD21689.1| (AC004793) Identical to gb|X71364 gene for aspartate kinase
           homoserine dehydrogenase from Arabidopsis thaliana
           Length = 911
           
 Score =  100 bits (246), Expect = 3e-20
 Identities = 91/364 (25%), Positives = 155/364 (42%), Gaps = 59/364 (16%)

Query: 5   VSVFGFGTVGRALAEIIAEKRKV----FGVELNVVSITDRSGTIWGD--FDLLEAKEVKE 58
           V + G G +G  L + I ++  V    F ++L V+ IT  S  +  +   DL   +E+ +
Sbjct: 555 VGIIGPGLIGGTLLDQIRDQAAVLKEEFKIDLRVIGITGSSKMLMSESGIDLSRWRELMK 614

Query: 59  STGKLSNIGEYEVY----DFSPQELIEEVKPDILVDVSSWDDAHEMYSYALAEGISVVTS 114
             G+ +++ ++  Y     F P          ++VD ++  D    Y   L  GI VVT 
Sbjct: 615 EEGEKADMEKFTQYVKGNHFIPNS--------VMVDCTADADIASCYYDWLLRGIHVVTP 666

Query: 115 NKPPIANHYDELIT---LARENGVGIFFESTVMAGTPIIGLLRENL-LGEEIVKMEAIVN 170
           NK   +   D+ +    L R++    F+E+TV AG PII  LR  L  G++I+++E I +
Sbjct: 667 NKKANSGPLDQYLKIRDLQRKSYTHYFYEATVGAGLPIISTLRGLLETGDKILRIEGIFS 726

Query: 171 ASTTFILTRMENGKTFEEAMEEARTLGILEEDPSKDIDGIDAYYKAKILHWVS------- 223
            + +++       ++F E + EA+  G  E DP  D+ G D   K  IL   S       
Sbjct: 727 GTLSYLFNNFVGTRSFSEVVAEAKQAGFTEPDPRDDLSGTDVARKVTILARESGLKLDLE 786

Query: 224 ---------------------------YGEQPEEEEREGIRNVKDARNVRLVAEISKGRI 256
                                      + E+  ++  E     +  R V +V  + K   
Sbjct: 787 GLPVQNLVPKPLQACASAEEFMEKLPQFDEELSKQREEAEAAGEVLRYVGVVDAVEKKGT 846

Query: 257 SVAPRKLPDNSPLLVSEVENAALIKTENL---TLTLKGPGGGGKVTASGVFTDIIKAALK 313
               R   D+    +S  +N     T+      L ++GPG G +VTA G+F+DI++ A  
Sbjct: 847 VELKRYKKDHPFAQLSGADNIIAFTTKRYKEQPLIVRGPGAGAQVTAGGIFSDILRLAFY 906

Query: 314 FPSP 317
             +P
Sbjct: 907 LGAP 910


>sp|P44505|AKH_HAEIN BIFUNCTIONAL ASPARTOKINASE/HOMOSERINE DEHYDROGENASE (AK-HD)
           [INCLUDES: ASPARTOKINASE ; HOMOSERINE DEHYDROGENASE ]
           >gi|1073872|pir||A64048 aspartate kinase (EC 2.7.2.4) I
           / homoserine dehydrogenase  (EC 1.1.1.3) - Haemophilus
           influenzae (strain Rd KW20) >gi|1573040|gb|AAC21767.1|
           (U32694) aspartokinase I / homoserine dehydrogenase I
           (thrA) [Haemophilus influenzae Rd]
           Length = 815
           
 Score =  100 bits (246), Expect = 3e-20
 Identities = 99/350 (28%), Positives = 162/350 (46%), Gaps = 47/350 (13%)

Query: 3   VKVSVFGFGTVGRALAEIIAEKRKVFG---VELNVVSITDRSGTIWGDFDLLEAKEVKES 59
           V + + G G VG  L E +  +++      VE+ V +I + S  +  D + L  ++ K  
Sbjct: 466 VDMFLVGVGGVGGELIEQVKRQKEYLAKKNVEIRVCAIAN-SNRMLLDENGLNLEDWKND 524

Query: 60  TGKLSNIGEYEVYDFSPQELIEEVKPDILVDVSSWDDAHEMYSYALAEGISVVTSNKPPI 119
               +   +++V   S  +L   V P + VD +S +    +Y+ AL EG  VVT NK   
Sbjct: 525 LENATQPSDFDVL-LSFIKLHHVVNP-VFVDCTSAESVAGLYARALKEGFHVVTPNKKAN 582

Query: 120 AN---HYDELITLARENGVGIFFESTVMAGTPIIGLLRENLL--GEEIVKMEAIVNASTT 174
                +Y+EL   A+ +     +E+ V AG P+I  L +NLL  G+E+   E I++ S +
Sbjct: 583 TRELVYYNELRQNAQASQHKFLYETNVGAGLPVIENL-QNLLAAGDELEYFEGILSGSLS 641

Query: 175 FILTRMENGKTFEEAMEEARTLGILEEDPSKDIDGIDAYYKAKIL--------------- 219
           FI  ++E G +  E    AR  G  E DP  D+ G D   K  IL               
Sbjct: 642 FIFGKLEEGLSLSEVTALAREKGFTEPDPRDDLSGQDVARKLLILAREAGIELELSDVEV 701

Query: 220 ---------------HWVSYGEQPEEEEREGIRNVK-DARNVRLVAEISKGRISVAPRKL 263
                           +++   Q +EE +  +   K + + +R V +IS+G+  V+   +
Sbjct: 702 EGVLPKGFSDGKSADEFMAMLPQLDEEFKTRVATAKAEGKVLRYVGKISEGKCKVSIVAV 761

Query: 264 PDNSPLL-VSEVENAALIKT---ENLTLTLKGPGGGGKVTASGVFTDIIK 309
             N+PL  V + ENA    T   + + L L+G G G  VTA+G+F DI++
Sbjct: 762 DLNNPLYKVKDGENALAFYTRYYQPIPLLLRGYGAGNAVTAAGIFADILR 811


>sp|P49079|AKH1_MAIZE BIFUNCTIONAL ASPARTOKINASE/HOMOSERINE DEHYDROGENASE 1, CHLOROPLAST
           PRECURSOR (AK-HD 1) (AK-HSDH 1) [INCLUDES: ASPARTOKINASE
           ; HOMOSERINE DEHYDROGENASE ] >gi|7434566|pir||T02953
           aspartate kinase (EC 2.7.2.4) / homoserine dehydrogenase
           (EC 1.1.1.3) - maize >gi|500851|gb|AAA74360.1| (L33912)
           aspartate kinase-homoserine dehydrogenase [Zea mays]
           Length = 920
           
 Score = 98.3 bits (241), Expect = 1e-19
 Identities = 96/361 (26%), Positives = 161/361 (44%), Gaps = 53/361 (14%)

Query: 5   VSVFGFGTVGRALAEIIAEKRKVF----GVELNVVSITDRSGTIWGDF--DLLEAKEVKE 58
           V + G G +GR L   + ++  V      ++L V+ I      +  D   DL + KE  +
Sbjct: 564 VGIIGPGLIGRTLLNQLKDQAAVLKENMNIDLRVMGIAGSRTMLLSDIGVDLTQWKEKLQ 623

Query: 59  STGKLSNIGEYEVYDFSPQELIEEVKPDILVDVSSWDDAHEMYSYALAEGISVVTSNKPP 118
           +  + +N+ ++ V+  S           +LVD ++       Y   L +GI V+T NK  
Sbjct: 624 TEAEPANLDKF-VHHLSENHFFPN---RVLVDCTADTSVASHYYDWLKKGIHVITPNKKA 679

Query: 119 IA---NHYDELITLARENGVGIFFESTVMAGTPIIGLLRENL-LGEEIVKMEAIVNASTT 174
            +   + Y +L TL R +    F+E+TV AG PII  LR  L  G++I+++E I + + +
Sbjct: 680 NSGPLDRYLKLRTLQRASYTHYFYEATVGAGLPIISTLRGLLETGDKILRIEGIFSGTLS 739

Query: 175 FILTRMENGKTFEEAMEEARTLGILEEDPSKDIDGIDAYYKAKILHWVS----------- 223
           +I    E  +TF + + EA+  G  E DP  D+ G D   K  IL   S           
Sbjct: 740 YIFNNFEGARTFSDVVAEAKKAGYTEPDPRDDLSGTDVARKVIILARESGLGLELSDIPV 799

Query: 224 ----------------YGEQPEEEEREGIRNVKDA-------RNVRLVAEIS-KGRISVA 259
                           Y ++    + +  R  K+A       R V +V  +S KG++ + 
Sbjct: 800 RSLVPEALKSCTSADEYMQKLPSFDEDWARERKNAEAAGEVLRYVGVVDVVSKKGQVELR 859

Query: 260 PRKLPDNSPLLVSEVENAALIKT---ENLTLTLKGPGGGGKVTASGVFTDIIKAALKFPS 316
             K  D+    +S  +N     T   ++  L ++GPG G +VTA GVF DI++ +    +
Sbjct: 860 AYK-RDHPFAQLSGSDNIIAFTTSRYKDQPLIVRGPGAGAEVTAGGVFCDILRLSSYLGA 918

Query: 317 P 317
           P
Sbjct: 919 P 919


>sp|P27725|AK1H_SERMA BIFUNCTIONAL ASPARTOKINASE/HOMOSERINE DEHYDROGENASE I (AKI-HDI)
           [INCLUDES: ASPARTOKINASE I ; HOMOSERINE DEHYDROGENASE I
           ] >gi|421254|pir||B47057 aspartate kinase (EC 2.7.2.4) I
           / homoserine dehydrogenase  (EC 1.1.1.3) I - Serratia
           marcescens >gi|47273|emb|CAA43212.1| (X60821) aspartate
           kinase [Serratia marcescens]
           Length = 819
           
 Score = 96.0 bits (235), Expect = 5e-19
 Identities = 100/359 (27%), Positives = 160/359 (43%), Gaps = 65/359 (18%)

Query: 3   VKVSVFGFGTVGRALAEIIAEKR----------KVFGVELNVVSITDRSGTIWGDF-DLL 51
           ++V V G G VG AL E I  ++          +V G+  + V +T+  G     + D L
Sbjct: 466 IEVFVIGVGGVGGALIEQIYRQQPWLKQKHIDLRVCGIANSRVMLTNVHGIALDSWRDAL 525

Query: 52  EAKEVKESTGKLSN-IGEYEVYDFSPQELIEEVKPDILVDVSSWDDAHEMYSYALAEGIS 110
              +   + G+L   + EY + +             ++VD +S     + Y   LA+G  
Sbjct: 526 AGAQEPFNLGRLIRLVKEYHLLN------------PVIVDCTSSQAVADQYVDFLADGFH 573

Query: 111 VVTSNKPPIA---NHYDELITLARENGVGIFFESTVMAGTPIIGLLRENLL--GEEIVKM 165
           VVT NK       N+Y +L   A  +     +++ V AG P+I  L +NLL  G+E+V+ 
Sbjct: 574 VVTPNKKANTSSMNYYQQLRAAAAGSHRKFLYDTNVGAGLPVIENL-QNLLNAGDELVRF 632

Query: 166 EAIVNASTTFILTRMENGKTFEEAMEEARTLGILEEDPSKDIDGIDAYYKAKIL------ 219
             I++ S +FI  +++ G +   A  +AR  G  E DP  D+ G+D   K  IL      
Sbjct: 633 SGILSGSLSFIFGKLDEGLSLSAATLQARANGYTEPDPRDDLSGMDVARKLLILAREAGY 692

Query: 220 ---------------HWVSYGE------QPEEEEREGIRNVKDA----RNVRLVAEISKG 254
                           + + G+      +  E ++E  RNV +A    + +R V  I +G
Sbjct: 693 KLELSDIEVEPVLPPSFDASGDVDTFLARLPELDKEFARNVANAAEQGKVLRYVGLIDEG 752

Query: 255 RISVAPRKLPDNSPLL-VSEVENAALIKT---ENLTLTLKGPGGGGKVTASGVFTDIIK 309
           R  V    +  N PL  V   ENA    +   + L L L+G G G  VTA+GVF D+++
Sbjct: 753 RCKVRIEAVDGNDPLYKVKNGENALAFYSRYYQPLPLVLRGYGAGNDVTAAGVFADLLR 811


>dbj|BAA38474.1| (D10385) aspartokinase I-homoserine dehydrogenase I [Serratia
           marcescens]
           Length = 819
           
 Score = 96.0 bits (235), Expect = 5e-19
 Identities = 100/359 (27%), Positives = 160/359 (43%), Gaps = 65/359 (18%)

Query: 3   VKVSVFGFGTVGRALAEIIAEKR----------KVFGVELNVVSITDRSGTIWGDF-DLL 51
           ++V V G G VG AL E I  ++          +V G+  + V +T+  G     + D L
Sbjct: 466 IEVFVIGVGGVGGALIEQIYRQQPWLKQKHIDLRVCGIANSRVMLTNVHGIALDSWRDAL 525

Query: 52  EAKEVKESTGKLSN-IGEYEVYDFSPQELIEEVKPDILVDVSSWDDAHEMYSYALAEGIS 110
              +   + G+L   + EY + +             ++VD +S     + Y   LA+G  
Sbjct: 526 AGAQEPFNLGRLIRLVKEYHLLN------------PVIVDCTSSQAVADQYVDFLADGFH 573

Query: 111 VVTSNKPPIA---NHYDELITLARENGVGIFFESTVMAGTPIIGLLRENLL--GEEIVKM 165
           VVT NK       N+Y +L   A  +     +++ V AG P+I  L +NLL  G+E+V+ 
Sbjct: 574 VVTPNKKANTSSMNYYQQLRAAAAGSHRKFLYDTNVGAGLPVIENL-QNLLNAGDELVRF 632

Query: 166 EAIVNASTTFILTRMENGKTFEEAMEEARTLGILEEDPSKDIDGIDAYYKAKIL------ 219
             I++ S +FI  +++ G +   A  +AR  G  E DP  D+ G+D   K  IL      
Sbjct: 633 SGILSGSLSFIFGKLDEGLSLSAATLQARANGYTEPDPRDDLSGMDVARKLLILAREAGY 692

Query: 220 ---------------HWVSYGE------QPEEEEREGIRNVKDA----RNVRLVAEISKG 254
                           + + G+      +  E ++E  RNV +A    + +R V  I +G
Sbjct: 693 KLELSDIEVEPVLPPSFDASGDVDTFLARLPELDKEFARNVANAAEQGKVLRYVGLIDEG 752

Query: 255 RISVAPRKLPDNSPLL-VSEVENAALIKT---ENLTLTLKGPGGGGKVTASGVFTDIIK 309
           R  V    +  N PL  V   ENA    +   + L L L+G G G  VTA+GVF D+++
Sbjct: 753 RCKVRIEAVDGNDPLYKVKNGENALAFYSRYYQPLPLVLRGYGAGNDVTAAGVFADLLR 811


>dbj|BAA38480.1| (D10387) aspartokinase I-homoserine dehydrogenase I [Serratia
           marcescens]
           Length = 819
           
 Score = 96.0 bits (235), Expect = 5e-19
 Identities = 100/359 (27%), Positives = 160/359 (43%), Gaps = 65/359 (18%)

Query: 3   VKVSVFGFGTVGRALAEIIAEKR----------KVFGVELNVVSITDRSGTIWGDF-DLL 51
           ++V V G G VG AL E I  ++          +V G+  + V +T+  G     + D L
Sbjct: 466 IEVFVIGVGGVGGALIEQIYRQQPWLKQKHIDLRVCGIANSRVMLTNVHGIALDSWRDAL 525

Query: 52  EAKEVKESTGKLSN-IGEYEVYDFSPQELIEEVKPDILVDVSSWDDAHEMYSYALAEGIS 110
              +   + G+L   + EY + +             ++VD +S     + Y   LA+G  
Sbjct: 526 AGAQEPFNLGRLIRLVKEYHLLN------------PVIVDCTSSQAVADQYVDFLADGFH 573

Query: 111 VVTSNKPPIA---NHYDELITLARENGVGIFFESTVMAGTPIIGLLRENLL--GEEIVKM 165
           VVT NK       N+Y +L   A  +     +++ V AG P+I  L +NLL  G+E+V+ 
Sbjct: 574 VVTPNKKANTSSMNYYQQLRAAAAGSHRKFLYDTNVGAGLPVIENL-QNLLNAGDELVRF 632

Query: 166 EAIVNASTTFILTRMENGKTFEEAMEEARTLGILEEDPSKDIDGIDAYYKAKIL------ 219
             I++ S +FI  +++ G +   A  +AR  G  E DP  D+ G+D   K  IL      
Sbjct: 633 SGILSGSLSFIFGKLDEGLSLSAATLQARANGYTEPDPRDDLSGMDVARKLLILAREAGY 692

Query: 220 ---------------HWVSYGE------QPEEEEREGIRNVKDA----RNVRLVAEISKG 254
                           + + G+      +  E ++E  RNV +A    + +R V  I +G
Sbjct: 693 KLELSDIEVEPVLPPSFDASGDVDTFLARLPELDKEFARNVANAAEQGKVLRYVGLIDEG 752

Query: 255 RISVAPRKLPDNSPLL-VSEVENAALIKT---ENLTLTLKGPGGGGKVTASGVFTDIIK 309
           R  V    +  N PL  V   ENA    +   + L L L+G G G  VTA+GVF D+++
Sbjct: 753 RCKVRIEAVDGNDPLYKVKNGENALAFYSRYYQPLPLVLRGYGAGNDVTAAGVFADLLR 811


>sp|P49080|AKH2_MAIZE BIFUNCTIONAL ASPARTOKINASE/HOMOSERINE DEHYDROGENASE 2, CHLOROPLAST
           PRECURSOR (AK-HD 2) (AK-HSDH 2) [INCLUDES: ASPARTOKINASE
           ; HOMOSERINE DEHYDROGENASE ] >gi|7434567|pir||T02954
           aspartate kinase (EC 2.7.2.4) / homoserine dehydrogenase
           (EC 1.1.1.3) precursor - maize >gi|500853|gb|AAA74361.1|
           (L33913) aspartate kinase-homoserine dehydrogenase [Zea
           mays]
           Length = 917
           
 Score = 96.0 bits (235), Expect = 5e-19
 Identities = 91/360 (25%), Positives = 154/360 (42%), Gaps = 51/360 (14%)

Query: 5   VSVFGFGTVGRALAEIIAEKRKVF----GVELNVVSITDRSGTIWGD--FDLLEAKEVKE 58
           V + G G +G AL   +  +  V      ++L V+ IT  S  +  D   DL + K++ +
Sbjct: 561 VGIIGPGLIGGALLNQLKNQTAVLKENMNIDLRVIGITGSSTMLLSDTGIDLTQWKQLLQ 620

Query: 59  STGKLSNIGEYEVYDFSPQELIEEVKPDILVDVSSWDDAHEMYSYALAEGISVVTSNKPP 118
              + ++IG + V+  S   +       +LVD ++       Y   L +GI V+T NK  
Sbjct: 621 KEAEPADIGSF-VHHLSDNHVFPN---KVLVDCTADTSVASHYYDWLKKGIHVITPNKKA 676

Query: 119 IANHYDELI---TLARENGVGIFFESTVMAGTPIIGLLRENL-LGEEIVKMEAIVNASTT 174
            +   D+ +   T+ R +    F+E+TV AG PII  LR  L  G++I+++E I + + +
Sbjct: 677 NSGPLDQYLKLRTMQRASYTHYFYEATVGAGLPIISTLRGLLETGDKILRIEGIFSGTLS 736

Query: 175 FILTRMENGKTFEEAMEEARTLGILEEDPSKDIDGIDAYYKAKILHWVS----------- 223
           +I    E  + F + + EAR  G  E DP  D+ G D   K  +L   S           
Sbjct: 737 YIFNNFEGTRAFSDVVAEAREAGYTEPDPRDDLSGTDVARKVVVLARESGLRLELSDIPV 796

Query: 224 ----------------YGEQPEEEEREGIRNVKDA-------RNVRLVAEISKGRISVAP 260
                           + ++    + +  R   DA       R V  +  +++       
Sbjct: 797 KSLVPETLASCSSADEFMQKLPSFDEDWARQRSDAEAAGEVLRYVGALDAVNRSGQVELR 856

Query: 261 RKLPDNSPLLVSEVENAALIKT---ENLTLTLKGPGGGGKVTASGVFTDIIKAALKFPSP 317
           R   D+    +S  +N     T   +   L ++GPG G +VTA GVF DI++ A    +P
Sbjct: 857 RYRRDHPFAQLSGSDNIIAFTTSRYKEQPLIVRGPGAGAEVTAGGVFCDILRLASYLGAP 916


>dbj|BAA38477.1| (D10386) aspartokinase I-homoserine dehydrogenase I [Serratia
           marcescens]
           Length = 819
           
 Score = 94.4 bits (231), Expect = 2e-18
 Identities = 99/359 (27%), Positives = 159/359 (43%), Gaps = 65/359 (18%)

Query: 3   VKVSVFGFGTVGRALAEIIAEKR----------KVFGVELNVVSITDRSGTIWGDF-DLL 51
           ++V V G G VG  L E I  ++          +V G+  + V +T+  G     + D L
Sbjct: 466 IEVFVIGVGGVGGTLIEQIYRQQPWLKQKHIDLRVCGIANSRVMLTNVHGIALDSWRDAL 525

Query: 52  EAKEVKESTGKLSN-IGEYEVYDFSPQELIEEVKPDILVDVSSWDDAHEMYSYALAEGIS 110
              +   + G+L   + EY + +             ++VD +S     + Y   LA+G  
Sbjct: 526 AGAQEPFNLGRLIRLVKEYHLLN------------PVIVDCTSSQAVADQYVDFLADGFH 573

Query: 111 VVTSNKPPIA---NHYDELITLARENGVGIFFESTVMAGTPIIGLLRENLL--GEEIVKM 165
           VVT NK       N+Y +L   A  +     +++ V AG P+I  L +NLL  G+E+V+ 
Sbjct: 574 VVTPNKKANTSSMNYYQQLRAAAAGSHRKFLYDTNVGAGLPVIENL-QNLLNAGDELVRF 632

Query: 166 EAIVNASTTFILTRMENGKTFEEAMEEARTLGILEEDPSKDIDGIDAYYKAKIL------ 219
             I++ S +FI  +++ G +   A  +AR  G  E DP  D+ G+D   K  IL      
Sbjct: 633 SGILSGSLSFIFGKLDEGLSLSAATLQARANGYTEPDPRDDLSGMDVARKLLILAREAGY 692

Query: 220 ---------------HWVSYGE------QPEEEEREGIRNVKDA----RNVRLVAEISKG 254
                           + + G+      +  E ++E  RNV +A    + +R V  I +G
Sbjct: 693 KLELSDIEVEPVLPPSFDASGDVDTFLARLPELDKEFARNVANAAEQGKVLRYVGLIDEG 752

Query: 255 RISVAPRKLPDNSPLL-VSEVENAALIKT---ENLTLTLKGPGGGGKVTASGVFTDIIK 309
           R  V    +  N PL  V   ENA    +   + L L L+G G G  VTA+GVF D+++
Sbjct: 753 RCKVRIEAVDGNDPLYKVKNGENALAFYSRYYQPLPLVLRGYGAGNDVTAAGVFADLLR 811


>pir||DEECK thrA bifunctional enzyme - Escherichia coli
           >gi|537245|gb|AAA97301.1| (U14003) aspartokinase
           I-homoserine dehydrogenase I [Escherichia coli]
           >gi|1786183|gb|AAC73113.1| (AE000111) aspartokinase I,
           homoserine dehydrogenase I [Escherichia coli K12]
           Length = 820
           
 Score = 89.7 bits (219), Expect = 4e-17
 Identities = 99/360 (27%), Positives = 158/360 (43%), Gaps = 66/360 (18%)

Query: 3   VKVSVFGFGTVGRALAEIIAEKR----------KVFGVELNVVSITDRSGTIWGDF--DL 50
           ++V V G G VG AL E +  ++          +V GV  +   +T+  G    ++  +L
Sbjct: 466 IEVFVIGVGGVGGALLEQLKRQQSWLKNKHIDLRVCGVANSKALLTNVHGLNLENWQEEL 525

Query: 51  LEAKEVKESTGKLSNIGEYEVYDFSPQELIEEVKPDILVDVSSWDDAHEMYSYALAEGIS 110
            +AKE       +  + EY + +             ++VD +S     + Y+  L EG  
Sbjct: 526 AQAKEPFNLGRLIRLVKEYHLLN------------PVIVDCTSSQAVADQYADFLREGFH 573

Query: 111 VVTSNKPPIAN---HYDELITLARENGVGIFFESTVMAGTPIIGLLRENLL--GEEIVKM 165
           VVT NK    +   +Y +L   A ++     +++ V AG P+I  L +NLL  G+E++K 
Sbjct: 574 VVTPNKKANTSSMDYYHQLRYAAEKSRRKFLYDTNVGAGLPVIENL-QNLLNAGDELMKF 632

Query: 166 EAIVNASTTFILTRMENGKTFEEAMEEARTLGILEEDPSKDIDGIDAYYKAKILHWVSYG 225
             I++ S ++I  +++ G +F EA   AR +G  E DP  D+ G+D   K  IL   +  
Sbjct: 633 SGILSGSLSYIFGKLDEGMSFSEATTLAREMGYTEPDPRDDLSGMDVARKLLILARETGR 692

Query: 226 E-----------QPEEEEREG----------------IRNVKDARN----VRLVAEISK- 253
           E            P E   EG                   V  AR+    +R V  I + 
Sbjct: 693 ELELADIEIEPVLPAEFNAEGDVAAFMANLSQLDDLFAARVAKARDEGKVLRYVGNIDED 752

Query: 254 GRISVAPRKLPDNSPLL-VSEVENAALIKT---ENLTLTLKGPGGGGKVTASGVFTDIIK 309
           G   V   ++  N PL  V   ENA    +   + L L L+G G G  VTA+GVF D+++
Sbjct: 753 GVCRVKIAEVDGNDPLFKVKNGENALAFYSHYYQPLPLVLRGYGAGNDVTAAGVFADLLR 812


>sp|P37142|AKH_DAUCA BIFUNCTIONAL ASPARTOKINASE/HOMOSERINE DEHYDROGENASE, CHLOROPLAST
           PRECURSOR (AK-HD) (AK-HSDH) [INCLUDES: ASPARTOKINASE ;
           HOMOSERINE DEHYDROGENASE ] >gi|486738|pir||S35160
           aspartate kinase (EC 2.7.2.4) / homoserine dehydrogenase
           (EC 1.1.1.3) precursor - carrot
           >gi|464225|gb|AAA16972.1| (L11529)
           aspartokinase-homoserine dehydrogenase [Daucus carota]
           Length = 921
           
 Score = 89.7 bits (219), Expect = 4e-17
 Identities = 86/362 (23%), Positives = 157/362 (42%), Gaps = 51/362 (14%)

Query: 3   VKVSVFGFGTVGRALAEIIAEKRKVFG----VELNVVSITDRSGTIWGD--FDLLEAKEV 56
           + V + G G +G  L + + ++  +      ++L V+ IT     +  +   DL   +EV
Sbjct: 563 IAVGIVGPGLIGATLLDQLRDQAAILKENSKIDLRVMGITGSRTMLLSETGIDLSRWREV 622

Query: 57  KESTGKLSNIGEYEVYDFSPQELIEEVKPDILVDVSSWDDAHEMYSYALAEGISVVTSNK 116
           ++  G+ + + ++ V        I      ++VD ++  +    Y   L  GI V+T NK
Sbjct: 623 QKEKGQTAGLEKF-VQHVRGNHFIPST---VIVDCTADSEVASHYHDWLCRGIHVITPNK 678

Query: 117 PPIANHYDELI---TLARENGVGIFFESTVMAGTPIIGLLRENL-LGEEIVKMEAIVNAS 172
              +   D+ +    L R +    F+E+TV+AG PII  L+  L  G++I+++E I + +
Sbjct: 679 KANSGPLDQYLKLRALQRRSYTHYFYEATVVAGLPIITTLQGLLETGDKILRIEGIFSGT 738

Query: 173 TTFILTRMENGKTFEEAMEEARTLGILEEDPSKDIDGIDAYYKAKI-------------- 218
            ++I    ++   F E + EA+  G  E DP  D+ G D   K  I              
Sbjct: 739 LSYIFNNFKSTTPFSEVVSEAKAAGYTEPDPRDDLAGTDVARKVIILARGSGLKLELSDI 798

Query: 219 ---------LHWVSYGE----QPEEEEREGIRNVKDARN-------VRLVAEISKGRISV 258
                    L  ++  E    Q  + + +  R  +DA N       V +V  +++  +  
Sbjct: 799 PVQSLVPEPLRGIASAEEFLLQLPQFDSDMTRKREDAENAGEVLRYVGVVDAVNQKGVVE 858

Query: 259 APRKLPDNSPLLVSEVENAALIKTENLTL---TLKGPGGGGKVTASGVFTDIIKAALKFP 315
             R   ++    +S  +N     TE        ++GPG G +VTA GVF+DI++ A    
Sbjct: 859 LKRYKKEHPFAQLSGSDNINAFTTERYNKQPPIIRGPGAGAEVTAGGVFSDILRLASYLG 918

Query: 316 SP 317
           +P
Sbjct: 919 AP 920


>pir||T04752 aspartate kinase (EC 2.7.2.4) / homoserine dehydrogenase (EC
           1.1.1.3) T16H5.70 - Arabidopsis thaliana
           >gi|3250680|emb|CAA19688.1| (AL024486) aspartate
           kinase-homoserine dehydrogenase-like protein
           [Arabidopsis thaliana] >gi|7268767|emb|CAB78973.1|
           (AL161551) aspartate kinase-homoserine
           dehydrogenase-like protein [Arabidopsis thaliana]
           Length = 916
           
 Score = 87.8 bits (214), Expect = 1e-16
 Identities = 92/364 (25%), Positives = 157/364 (42%), Gaps = 59/364 (16%)

Query: 5   VSVFGFGTVGRALAEIIAEKRKV----FGVELNVVSITDRSGTIWGDF--DLLEAKEVKE 58
           + + G G +G  L + + ++  V    F ++L V+ IT     +  D   DL   +E+  
Sbjct: 560 MGIVGPGLIGATLLDQLRDQAAVLKQEFNIDLRVLGITGSKKMLLSDIGIDLSRWRELLN 619

Query: 59  STGKLSNIGEY--EVYD--FSPQELIEEVKPDILVDVSSWDDAHEMYSYALAEGISVVTS 114
             G  +++ ++  +V+   F P  ++ +   D  +       A   Y + L +GI V+T 
Sbjct: 620 EKGTEADLDKFTQQVHGNHFIPNSVVVDCTADSAI-------ASRYYDW-LRKGIHVITP 671

Query: 115 NKPPIANHYDELITLA---RENGVGIFFESTVMAGTPIIGLLRENL-LGEEIVKMEAIVN 170
           NK   +   D+ + L    R++    F+E+TV AG PII  LR  L  G++I+++E I +
Sbjct: 672 NKKANSGPLDQYLKLRDLQRKSYTHYFYEATVGAGLPIISTLRGLLETGDKILRIEGICS 731

Query: 171 ASTTFILTRMENGKTFEEAMEEARTLGILEEDPSKDIDGIDAYYKAKILHWVS-----YG 225
            + +++       ++F E + EA+  G  E DP  D+ G D   K  IL   S       
Sbjct: 732 GTLSYLFNNFVGDRSFSEVVTEAKNAGFTEPDPRDDLSGTDVARKVIILARESGLKLDLA 791

Query: 226 EQP----EEEEREGIRNVK-----------DARNVRLVAEIS---------------KGR 255
           + P      E  +G  +V+           D    RL AE S               KG 
Sbjct: 792 DLPIRSLVPEPLKGCTSVEEFMEKLPQYDGDLAKERLDAENSGEVLRYVGVVDAVNQKGT 851

Query: 256 ISVAPRKLPDNSPLLVSEVENAALIKT--ENLTLTLKGPGGGGKVTASGVFTDIIKAALK 313
           + +   K       L       A   T  ++  L ++GPG G +VTA G+F+DI++ A  
Sbjct: 852 VELRRYKKEHPFAQLAGSDNIIAFTTTRYKDHPLIVRGPGAGAQVTAGGIFSDILRLASY 911

Query: 314 FPSP 317
             +P
Sbjct: 912 LGAP 915


>emb|CAA23660.1| (V00361) thrA gene [EC 2.7.2.4 and EC 1.1.1.3] [Escherichia coli]
           >gi|147979|gb|AAA83914.1| (J01706) aspartokinase
           I-homoserine dehydrogenase I [Escherichia coli]
           >gi|216435|dbj|BAA01286.1| (D10483) aspartokinase I
           [Escherichia coli]
           Length = 820
           
 Score = 87.0 bits (212), Expect = 3e-16
 Identities = 98/360 (27%), Positives = 157/360 (43%), Gaps = 66/360 (18%)

Query: 3   VKVSVFGFGTVGRALAEIIAEKR----------KVFGVELNVVSITDRSGTIWGDF--DL 50
           ++V V G G VG AL E +  ++          +V GV  +   +T+  G    ++  +L
Sbjct: 466 IEVFVIGVGGVGGALLEQLKRQQSWLKNKHIDLRVCGVANSKALLTNVHGLNLENWQEEL 525

Query: 51  LEAKEVKESTGKLSNIGEYEVYDFSPQELIEEVKPDILVDVSSWDDAHEMYSYALAEGIS 110
            +AKE       +  + EY + +             ++V+ +S     + Y+  L EG  
Sbjct: 526 AQAKEPFNLGRLIRLVKEYHLLN------------PVIVNCTSSQAVADQYADFLREGFH 573

Query: 111 VVTSNKPPIAN---HYDELITLARENGVGIFFESTVMAGTPIIGLLRENLL--GEEIVKM 165
           VVT NK    +   +Y +L   A ++     ++  V AG P+I  L +NLL  G+E++K 
Sbjct: 574 VVTPNKKANTSSMDYYHQLRYAAEKSRRKFLYDINVGAGLPVIENL-QNLLNAGDELMKF 632

Query: 166 EAIVNASTTFILTRMENGKTFEEAMEEARTLGILEEDPSKDIDGIDAYYKAKILHWVSYG 225
             I++ S ++I  +++ G +F EA   AR +G  E DP  D+ G+D   K  IL   +  
Sbjct: 633 SGILSGSLSYIFGKLDEGMSFSEATRLAREMGYTEPDPRDDLSGMDVARKLLILARETGR 692

Query: 226 E-----------QPEEEEREG----------------IRNVKDARN----VRLVAEISK- 253
           E            P E   EG                   V  AR+    +R V  I + 
Sbjct: 693 ELELADIEIEPVLPAEFNAEGDVAAFMANLSQLDDLFAARVAKARDEGKVLRYVGNIDED 752

Query: 254 GRISVAPRKLPDNSPLL-VSEVENAALIKT---ENLTLTLKGPGGGGKVTASGVFTDIIK 309
           G   V   ++  N PL  V   ENA    +   + L L L+G G G  VTA+GVF D+++
Sbjct: 753 GVCRVKIAEVDGNDPLFKVKNGENALAFYSHYYQPLPLVLRGYGAGNDVTAAGVFADLLR 812


>sp|P00561|AK1H_ECOLI BIFUNCTIONAL ASPARTOKINASE/HOMOSERINE DEHYDROGENASE I (AKI-HDI)
           [INCLUDES: ASPARTOKINASE I ; HOMOSERINE DEHYDROGENASE I
           ]
           Length = 820
           
 Score = 87.0 bits (212), Expect = 3e-16
 Identities = 98/360 (27%), Positives = 157/360 (43%), Gaps = 66/360 (18%)

Query: 3   VKVSVFGFGTVGRALAEIIAEKR----------KVFGVELNVVSITDRSGTIWGDF--DL 50
           ++V V G G VG AL E +  ++          +V GV  +   +T+  G    ++  +L
Sbjct: 466 IEVFVIGVGGVGGALLEQLKRQQSWLKNKHIDLRVCGVANSKALLTNVHGLNLENWQEEL 525

Query: 51  LEAKEVKESTGKLSNIGEYEVYDFSPQELIEEVKPDILVDVSSWDDAHEMYSYALAEGIS 110
            +AKE       +  + EY + +             ++V+ +S     + Y+  L EG  
Sbjct: 526 AQAKEPFNLGRLIRLVKEYHLLN------------PVIVNCTSSQAVADQYADFLREGFH 573

Query: 111 VVTSNKPPIAN---HYDELITLARENGVGIFFESTVMAGTPIIGLLRENLL--GEEIVKM 165
           VVT NK    +   +Y +L   A ++     ++  V AG P+I  L +NLL  G+E++K 
Sbjct: 574 VVTPNKKANTSSMDYYHQLRYAAEKSRRKFLYDINVGAGLPVIENL-QNLLNAGDELMKF 632

Query: 166 EAIVNASTTFILTRMENGKTFEEAMEEARTLGILEEDPSKDIDGIDAYYKAKILHWVSYG 225
             I++ S ++I  +++ G +F EA   AR +G  E DP  D+ G+D   K  IL   +  
Sbjct: 633 SGILSGSLSYIFGKLDEGMSFSEATRLAREMGYTEPDPRDDLSGMDVARKLLILARETGR 692

Query: 226 E-----------QPEEEEREG----------------IRNVKDARN----VRLVAEISK- 253
           E            P E   EG                   V  AR+    +R V  I + 
Sbjct: 693 ELELADIEIEPVLPAEFNAEGDVAAFMANLSQLDDLFAARVAKARDEGKVLRYVGNIDED 752

Query: 254 GRISVAPRKLPDNSPLL-VSEVENAALIKT---ENLTLTLKGPGGGGKVTASGVFTDIIK 309
           G   V   ++  N PL  V   ENA    +   + L L L+G G G  VTA+GVF D+++
Sbjct: 753 GVCRVKIAEVDGNDPLFKVKNGENALAFYSHYYQPLPLVLRGYGAGNDVTAAGVFADLLR 812


>gi|6322599 Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase); Hom6p
           [Saccharomyces cerevisiae]
           >gi|399368|sp|P31116|DHOM_YEAST HOMOSERINE DEHYDROGENASE
           (HDH) >gi|485487|pir||S33317 homoserine dehydrogenase
           (EC 1.1.1.3) - yeast (Saccharomyces cerevisiae)
           >gi|3797|emb|CAA45787.1| (X64457) homoserine
           dehydrogenase [Saccharomyces cerevisiae]
           >gi|1015880|emb|CAA89671.1| (Z49639) ORF YJR139c
           [Saccharomyces cerevisiae]
           Length = 359
           
 Score = 87.0 bits (212), Expect = 3e-16
 Identities = 92/354 (25%), Positives = 152/354 (41%), Gaps = 48/354 (13%)

Query: 3   VKVSVFGFGTVGRALAEIIAEKRKVFGVELNVVSITDRSGTIWGDFDLLEAKEVKESTGK 62
           V V+V G G VG A  + +   +      L +++  +RS  I  DF  L      ++   
Sbjct: 6   VNVAVIGAGVVGSAFLDQLLAMKSTITYNLVLLAEAERS-LISKDFSPLNVGSDWKAALA 64

Query: 63  LSNIGEYEVYDFSPQELIEEVKPDILVDVSSWDDAHEMYSYALAEGISVVTSNKPPIANH 122
            S      + D     L    KP ILVD +S       Y+  +  GIS+ T NK   ++ 
Sbjct: 65  ASTTKTLPLDDLIAH-LKTSPKPVILVDNTSSAYIAGFYTKFVENGISIATPNKKAFSSD 123

Query: 123 ---YDELITLARENGVGIFFESTVMAGTPIIGLLRENL-LGEEIVKMEAIVNASTTFIL- 177
              +  L +    NG  ++ E+TV AG PII  LRE +  G+E+ K+E I + + ++I  
Sbjct: 124 LATWKALFSNKPTNGF-VYHEATVGAGLPIISFLREIIQTGDEVEKIEGIFSGTLSYIFN 182

Query: 178 ---TRMENGKTFEEAMEEARTLGILEEDPSKDIDGIDAYYKAKILHWVS----------- 223
              T   N   F + ++ A+ LG  E DP  D++G+D   K  I+  +S           
Sbjct: 183 EFSTSQANDVKFSDVVKVAKKLGYTEPDPRDDLNGLDVARKVTIVGRISGVEVESPTSFP 242

Query: 224 -----------------YGEQPEEEEREGIRNVKDARNVRLV------AEISKGRISVAP 260
                            + E+  + +++  +  K+A     V       +++   +SV  
Sbjct: 243 VQSLIPKPLESVKSADEFLEKLSDYDKDLTQLKKEAATENKVLRFIGKVDVATKSVSVGI 302

Query: 261 RKLPDNSPLL-VSEVENAALIKTENLT--LTLKGPGGGGKVTASGVFTDIIKAA 311
            K   + P   +   +N   IKT+  T  + ++G G G  VTA+GV  D+IK A
Sbjct: 303 EKYDYSHPFASLKGSDNVISIKTKRYTNPVVIQGAGAGAAVTAAGVLGDVIKIA 356


>pdb|1EBF|A Chain A, Homoserine Dehydrogenase From S. Cerevisiae Complex With
           Nad+ >gi|7245385|pdb|1EBF|B Chain B, Homoserine
           Dehydrogenase From S. Cerevisiae Complex With Nad+
           >gi|7245386|pdb|1EBU|A Chain A, Homoserine Dehydrogenase
           Complex With Nad Analogue And L- Homoserine
           >gi|7245387|pdb|1EBU|B Chain B, Homoserine Dehydrogenase
           Complex With Nad Analogue And L- Homoserine
           >gi|7245388|pdb|1EBU|C Chain C, Homoserine Dehydrogenase
           Complex With Nad Analogue And L- Homoserine
           >gi|7245389|pdb|1EBU|D Chain D, Homoserine Dehydrogenase
           Complex With Nad Analogue And L- Homoserine
           Length = 358
           
 Score = 87.0 bits (212), Expect = 3e-16
 Identities = 92/354 (25%), Positives = 152/354 (41%), Gaps = 48/354 (13%)

Query: 3   VKVSVFGFGTVGRALAEIIAEKRKVFGVELNVVSITDRSGTIWGDFDLLEAKEVKESTGK 62
           V V+V G G VG A  + +   +      L +++  +RS  I  DF  L      ++   
Sbjct: 5   VNVAVIGAGVVGSAFLDQLLAMKSTITYNLVLLAEAERS-LISKDFSPLNVGSDWKAALA 63

Query: 63  LSNIGEYEVYDFSPQELIEEVKPDILVDVSSWDDAHEMYSYALAEGISVVTSNKPPIANH 122
            S      + D     L    KP ILVD +S       Y+  +  GIS+ T NK   ++ 
Sbjct: 64  ASTTKTLPLDDLIAH-LKTSPKPVILVDNTSSAYIAGFYTKFVENGISIATPNKKAFSSD 122

Query: 123 ---YDELITLARENGVGIFFESTVMAGTPIIGLLRENL-LGEEIVKMEAIVNASTTFIL- 177
              +  L +    NG  ++ E+TV AG PII  LRE +  G+E+ K+E I + + ++I  
Sbjct: 123 LATWKALFSNKPTNGF-VYHEATVGAGLPIISFLREIIQTGDEVEKIEGIFSGTLSYIFN 181

Query: 178 ---TRMENGKTFEEAMEEARTLGILEEDPSKDIDGIDAYYKAKILHWVS----------- 223
              T   N   F + ++ A+ LG  E DP  D++G+D   K  I+  +S           
Sbjct: 182 EFSTSQANDVKFSDVVKVAKKLGYTEPDPRDDLNGLDVARKVTIVGRISGVEVESPTSFP 241

Query: 224 -----------------YGEQPEEEEREGIRNVKDARNVRLV------AEISKGRISVAP 260
                            + E+  + +++  +  K+A     V       +++   +SV  
Sbjct: 242 VQSLIPKPLESVKSADEFLEKLSDYDKDLTQLKKEAATENKVLRFIGKVDVATKSVSVGI 301

Query: 261 RKLPDNSPLL-VSEVENAALIKTENLT--LTLKGPGGGGKVTASGVFTDIIKAA 311
            K   + P   +   +N   IKT+  T  + ++G G G  VTA+GV  D+IK A
Sbjct: 302 EKYDYSHPFASLKGSDNVISIKTKRYTNPVVIQGAGAGAAVTAAGVLGDVIKIA 355


>sp|P57290|AKH_BUCAI BIFUNCTIONAL ASPARTOKINASE/HOMOSERINE DEHYDROGENASE (AK-HD)
           [INCLUDES: ASPARTOKINASE ; HOMOSERINE DEHYDROGENASE ]
           >gi|10038876|dbj|BAB12911.1| (AP001118) aspartokinase I
           / homoserine dehydrogenase I [Buchnera sp. APS]
           Length = 816
           
 Score = 85.4 bits (208), Expect = 8e-16
 Identities = 96/359 (26%), Positives = 158/359 (43%), Gaps = 64/359 (17%)

Query: 3   VKVSVFGFGTVGRALAEIIAEKRKVF---GVELNVVSITDRSGTIWGDF--DLLEAK-EV 56
           + + + G G +G  L   I ++++      +E+ + +I +    +  D   DL   K + 
Sbjct: 467 IHMFLIGIGGIGSTLLNQILKQKQFLDKKNIEIKICAIANSKKILLLDNTNDLSNWKNDF 526

Query: 57  KESTGK-----LSNIGEYEVYDFSPQELIEEVKPDILVDVSSWDDAHEMYSYALAEGISV 111
           K+ST K     L+N+ +   +  S           ++VD +S     E Y   +     V
Sbjct: 527 KKSTQKFNLELLNNLIKNNHFSNS-----------VIVDCTSSQLLSEQYVNFIDNNFHV 575

Query: 112 VTSNKPPIA---NHYDELITLARENGVGIFFESTVMAGTPIIGLLRENLL--GEEIVKME 166
           VTSNK       N+Y ++     + G    +E+ V AG P+I  L +NL   G+ ++  +
Sbjct: 576 VTSNKKANTSEWNYYKKIRKSVAQTGKKFLYETNVGAGLPVIETL-QNLFKSGDNLICFK 634

Query: 167 AIVNASTTFILTRMENGKTFEEAMEEARTLGILEEDPSKDIDGIDAYYKAKILHWVS-YG 225
            I++ S +FI  R+E G    +A  EA+ LG  E +P  D+ GID   K  IL   S Y 
Sbjct: 635 GILSGSLSFIFGRLEEGILLSQATREAKELGFTEPNPCDDLSGIDVARKLLILARESGYN 694

Query: 226 EQPEEEEREGI--------------------------RNVKDARNV----RLVAEI-SKG 254
            + ++ + E +                            +K A NV    R VA I  K 
Sbjct: 695 IELKDIKIEPLLPNNFKIYEDTDKFLLKLKELDVYFSNKIKQALNVGNVLRFVATIEQKR 754

Query: 255 RISVAPRKLPDNSPLL-VSEVENAALIKT---ENLTLTLKGPGGGGKVTASGVFTDIIK 309
           +  +   ++  N+PL  V   ENA    T   + + L L+G G G  VTASGVF+D+++
Sbjct: 755 QFFIKLEEVNINNPLYKVKNGENALAFYTNYYQPIPLVLRGYGAGNNVTASGVFSDLLR 813


>pir||T03589 probable aspartate kinase (EC 2.7.2.4) / homoserine dehydrogenase
           (EC 1.1.1.3) precursor - rice
           >gi|1777375|dbj|BAA11417.1| (D78573) aspartate
           kinase-homoserine dehydrogenase [Oryza sativa]
           Length = 915
           
 Score = 83.9 bits (204), Expect = 2e-15
 Identities = 89/361 (24%), Positives = 153/361 (41%), Gaps = 53/361 (14%)

Query: 5   VSVFGFGTVGRALAEIIAEKRKVF----GVELNVVSITDRSGTIWGDF--DLLEAKEVKE 58
           V + G G +G  L + + ++  V      ++L V+ I+        D   DL + K++  
Sbjct: 559 VGIIGPGLIGGTLLDQLKDQAAVLKENMNIDLRVIGISGSRTMHLSDIGVDLNQWKDLLR 618

Query: 59  STGKLSNIGEYEVYDFSPQELIEEVKPDILVDVSSWDDAHEMYSYALAEGISVVTSNKPP 118
              + +++  + V   S   +       +LVD ++       Y   L +GI V+T NK  
Sbjct: 619 KEAEPADLDSF-VRHLSENHVFPN---KVLVDCTADTYVACHYYDWLKKGIHVITPNKKA 674

Query: 119 IA---NHYDELITLARENGVGIFFESTVMAGTPIIGLLRENL-LGEEIVKMEAIVNASTT 174
            +   + Y +L TL R +    F+E+TV AG PII  LR  L  G++I+++E I + + +
Sbjct: 675 NSGPLDRYLKLRTLQRASYTHYFYEATVGAGLPIISTLRGLLETGDKILRIEGIFSGTLS 734

Query: 175 FILTRMENGKTFEEAMEEARTLGILEEDPSKDIDGIDAYYKAKIL--------------- 219
           +I    E  +TF   + EA+  G  E DP  D+ G D   K  IL               
Sbjct: 735 YIFNNFEGTRTFSNVVAEAKEAGYTEPDPRDDLSGTDVARKVIILARESGLRLELSDIPV 794

Query: 220 ------------------HWVSYGEQPEEEEREGIRNVKDARNVRLVAEIS--KGRISVA 259
                               +   +Q  + +R+      +      V +++  KGR+ + 
Sbjct: 795 KSLLPEALRSCSSADEFMQKLPSFDQDWDRQRDEAEAAGEVLRYVGVVDVANRKGRVEL- 853

Query: 260 PRKLPDNSPLLVSEVENAALIKT---ENLTLTLKGPGGGGKVTASGVFTDIIKAALKFPS 316
            R   D+    +S  +N     T   +   L ++GPG G +VTA GVF DI++ A    +
Sbjct: 854 QRYKRDHPFAQLSGSDNIIAFTTSRYKEQPLIVRGPGAGAEVTAGGVFCDILRLASYLGA 913

Query: 317 P 317
           P
Sbjct: 914 P 914


>pir||T40673 homoserine dehydrogenase - fission yeast  (Schizosaccharomyces
           pombe) >gi|4176520|emb|CAA22876.1| (AL035263) homoserine
           dehydrogenase [Schizosaccharomyces pombe]
           Length = 376
           
 Score = 83.9 bits (204), Expect = 2e-15
 Identities = 98/359 (27%), Positives = 156/359 (43%), Gaps = 55/359 (15%)

Query: 3   VKVSVFGFGTVGRALAEIIA---EKRKVFGV-ELNVVSITDRSGT-IWGDFDLLEAKEVK 57
           V V++ G G +G  L   I    E     G    NVV+I+   G  +  D+  +   E K
Sbjct: 8   VNVAIVGTGNIGGELLNQIKGFNENASTNGTTSFNVVAISSMEGHYVSKDYQPINLSEWK 67

Query: 58  ESTGKLSNIGEYEVYDFSPQELIEEVKPDILVDVSSWDDAHEMYSYALAEGISVVTSNKP 117
             T +  N G Y + D     L +   P ILVD ++ +   + Y   L++ I++ T NK 
Sbjct: 68  NLTSQ--NQGAYSL-DALVDFLAKSPLPAILVDNTASEAIAQSYPKFLSKKINIATPNKK 124

Query: 118 PIA---NHYDELITLARENGVGIFFESTVMAGTPIIGLLRENL-LGEEIVKMEAIVNAST 173
             +   + Y  +I  ++E+G  +  E++V AG PII  L+E +  G+EI+K+E I + + 
Sbjct: 125 AFSASNDVYQNIIKASKESGALLMHEASVGAGLPIISTLKELIATGDEIIKIEGIFSGTL 184

Query: 174 TFILTRME-NGK----TFEEAMEEARTLGILEEDPSKDIDGIDAYYKAKIL------HWV 222
           ++I      NGK    +F + ++ A+  G  E DP  D++G+D   K  IL      H  
Sbjct: 185 SYIFNVWSPNGKKGTASFSDIVKIAKQNGYTEPDPRDDLNGMDVARKVTILSRIAGVHVE 244

Query: 223 SYGEQP--------------EEEEREGIRNV------------KDARNVRLV--AEISKG 254
           S    P               EE   G+ N             K+ + VR V  A+++  
Sbjct: 245 SASSFPVKSLIPEPLKSAVNAEEFLAGLPNFDSEFASMREEAEKEGKVVRFVGEADVANK 304

Query: 255 RISVAPRKLPDNSPLL-VSEVENAALIKTENL---TLTLKGPGGGGKVTASGVFTDIIK 309
              V   K   + P   +   +N     T+      L + G G G  VTA+GV  D+IK
Sbjct: 305 TTLVKLEKYDASHPFANLQSSDNIISFTTKRYHTRPLVVIGAGAGAAVTAAGVLGDMIK 363


>pir||G82583 bifunctional aspartokinase/homoserine dehydrogenase I XF2225
           [imported] - Xylella fastidiosa (strain 9a5c)
           >gi|9107374|gb|AAF85024.1|AE004035_3 (AE004035)
           bifunctional aspartokinase/homoserine dehydrogenase I
           [Xylella fastidiosa]
           Length = 828
           
 Score = 82.7 bits (201), Expect = 5e-15
 Identities = 68/264 (25%), Positives = 122/264 (45%), Gaps = 39/264 (14%)

Query: 87  ILVDVSSWDDAHEMYSYALAEGISVVTSNKPPIA---NHYDELITLARENGVGIFFESTV 143
           +++D S   +  + Y+  LA GI VVT NK   +   + Y  +   A  +G    +E+TV
Sbjct: 558 VIIDCSGSAEVADRYADWLAAGIHVVTPNKQAGSGPLHRYHAIRAAADASGARFRYEATV 617

Query: 144 MAGTPIIGLLRENL-LGEEIVKMEAIVNASTTFILTRMENGKTFEEAMEEARTLGILEED 202
            AG P+I  LR+ +  G+ +  +E I + +  ++  + +    F + + +AR +G  E D
Sbjct: 618 GAGLPVITTLRDLMDTGDSVTSIEGIFSGTLAWLFNKYDGSVPFSQLITQARAMGYTEPD 677

Query: 203 PSKDIDGIDAYYKAKIL-----------------------------HWVSYGEQPEEEER 233
           P  D+ G+D   K  IL                              +++   + +    
Sbjct: 678 PRDDLSGVDVARKLVILARDAGRDISLEDVAVESLVPETLCQLSVADFMARLNEVDATFA 737

Query: 234 EGIRNVKDARNV-RLVAEISKGRI-SVAPRKLP-DNSPLLVSEVENAALIKTENLT---L 287
           E +   K    V R VA++S G + SV+  +LP D++ + +   +N     T   +   L
Sbjct: 738 ERLAAAKQRGCVLRYVAQLSPGHVPSVSLIELPSDHAFVNLRLTDNVVQFTTRRYSENPL 797

Query: 288 TLKGPGGGGKVTASGVFTDIIKAA 311
            ++GPG G +VTA+GVF D+++ A
Sbjct: 798 VVQGPGAGPEVTAAGVFADLLRVA 821


>sp|P29365|DHOM_PSEAE HOMOSERINE DEHYDROGENASE (HDH) >gi|65916|pir||DEPSHA homoserine
           dehydrogenase (EC 1.1.1.3) - Pseudomonas aeruginosa
           >gi|45329|emb|CAA46167.1| (X65033) homoserine
           dehydrogenase [Pseudomonas aeruginosa]
           Length = 439
           
 Score = 80.4 bits (195), Expect = 3e-14
 Identities = 72/228 (31%), Positives = 109/228 (47%), Gaps = 18/228 (7%)

Query: 99  EMYSYALAEGISVVTSNKPPIANHYDELITLARENGVGIFFESTVMAGTPIIGLLRENLL 158
           E+   A+  G  VVT+NK  IA H    +      G    FE+ V  G P+I  +RE L 
Sbjct: 91  ELVLKAIENGKHVVTANKALIAVHGSRDLRQGPREGRDRAFEAAVAGGIPVIKAIREGLS 150

Query: 159 GEEIVKMEAIVNASTTFILTRM-ENGKTFEEAMEEARTLGI-LEEDPSKDIDGIDAYYKA 216
              I  +  I+N +  FIL+ M E G+TF + + EA+ LG      P+ D++GIDA  K 
Sbjct: 151 ANRINWLAGIINGTGNFILSEMREKGRTFPDVLAEAQALGYGRGRSPTFDVEGIDAATKL 210

Query: 217 KIL-HWVSYGEQPEEEEREGIR-------NVKDARNVRL----VAEISKG--RISVAPRK 262
            IL   + +  Q ++   EGI        N  DA   R+    VA  ++    + V P  
Sbjct: 211 TILASMLRHPLQFDKAYTEGISKLTSADVNYADALGYRIKHLGVARRTESGFELRVHPTL 270

Query: 263 LPDNSPLL-VSEVENAALIKTENLTLTL-KGPGGGGKVTASGVFTDII 308
           +P +  +  V+ V NA ++  + +  TL  G G G + TAS V  D++
Sbjct: 271 IPSDRLIANVTAVMNAVMVNGDAVGSTLYYGAGAGMEPTASSVVADLV 318


>sp|P37144|DHON_METGL HOMOSERINE DEHYDROGENASE (HDH) >gi|2160268|dbj|BAA40415.1| (D14071)
           homoserine dehydrogenase [Methylobacillus glycogenes]
           Length = 412
           
 Score = 79.6 bits (193), Expect = 4e-14
 Identities = 60/223 (26%), Positives = 106/223 (46%), Gaps = 23/223 (10%)

Query: 3   VKVSVFGFGTVGRALAEIIAEKRKVF----GVELNVVSITDRSGTIWGDFDLLEAKEVKE 58
           + V + G GTVG     ++   ++      G  + +  + DR+  +            ++
Sbjct: 4   INVGLLGIGTVGGGTYTVLTRNQEEIARRAGRPIAITRVADRNLEL-----------ARQ 52

Query: 59  STGKLSNIGEYEVYDFSPQELIEEVKPDILVD-VSSWDDAHEMYSYALAEGISVVTSNKP 117
            TG     G+ +V D     ++ +   DI+V+ +  +  A E+   A+  G  VVT+NK 
Sbjct: 53  VTG-----GKIDVTD-DAFAIVSDPAIDIVVELIGGYTVARELVLKAIENGKHVVTANKA 106

Query: 118 PIANHYDELITLARENGVGIFFESTVMAGTPIIGLLRENLLGEEIVKMEAIVNASTTFIL 177
            IA    + + L R+       +  ++  +P+   +RE L    I  +  I+N +T FIL
Sbjct: 107 LIACMAMKFLPLRRKKASSSLLKLPLLVVSPLFKAVREGLAANRIEWIAGIINGTTNFIL 166

Query: 178 TRM-ENGKTFEEAMEEARTLGILEEDPSKDIDGIDAYYKAKIL 219
           + M E G  F + ++EA+ LG  E DP+ D++GIDA +K  IL
Sbjct: 167 SEMREKGLAFADVLKEAQRLGYAEADPTFDVEGIDAAHKLMIL 209


>emb|CAB59717.1| (AL132707) putative homoserine dehydrogenase [Streptomyces
           coelicolor A3(2)]
           Length = 344
           
 Score = 75.7 bits (183), Expect = 6e-13
 Identities = 45/127 (35%), Positives = 64/127 (49%)

Query: 104 ALAEGISVVTSNKPPIANHYDELITLARENGVGIFFESTVMAGTPIIGLLRENLLGEEIV 163
           AL  GI VVT+ K  +  H+ +L   AR  G  I       A  P   L R +L G +  
Sbjct: 114 ALRRGIHVVTATKSHLLTHWRDLDAAARAGGSMIRISGATGAALPAGDLSRTSLRGLDCR 173

Query: 164 KMEAIVNASTTFILTRMENGKTFEEAMEEARTLGILEEDPSKDIDGIDAYYKAKILHWVS 223
            + A  N + TF+L R+  G T  +A+  A+  GI E DPS D+ G DA  K ++L  ++
Sbjct: 174 TIRACPNGTATFVLDRLAEGDTLGDAIRAAQLRGIAEADPSADLSGDDAATKVRLLAALA 233

Query: 224 YGEQPEE 230
           +G  P E
Sbjct: 234 WGWDPAE 240


  Database: ./suso.pep
    Posted date:  Jul 6, 2001  5:57 PM
  Number of letters in database: 840,471
  Number of sequences in database:  2977
  
  Database: /banques/blast2/nr.pep
    Posted date:  Dec 14, 2000 12:46 PM
  Number of letters in database: 188,266,275
  Number of sequences in database:  595,510
  
Lambda     K      H
   0.314    0.135    0.372 

Gapped
Lambda     K      H
   0.270   0.0470    0.230 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 115773883
Number of Sequences: 2977
Number of extensions: 4919483
Number of successful extensions: 11579
Number of sequences better than 1.0e-10: 57
Number of HSP's better than  0.0 without gapping: 10
Number of HSP's successfully gapped in prelim test: 47
Number of HSP's that attempted gapping in prelim test: 11419
Number of HSP's gapped (non-prelim): 85
length of query: 318
length of database: 189,106,746
effective HSP length: 60
effective length of query: 258
effective length of database: 153,197,526
effective search space: 39524961708
effective search space used: 39524961708
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 42 (21.9 bits)
S2: 165 (68.7 bits)