BLASTP 2.0.10 [Aug-26-1999]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= PAB0610 (hom) DE:homoserine dehydrogenase (hom)
(318 letters)
Database: ./suso.pep; /banques/blast2/nr.pep
598,487 sequences; 189,106,746 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
pir||F75138 homoserine dehydrogenase (hom) PAB0610 - Pyrococcus ... 627 e-179
pir||H71101 probable homoserine dehydrogenase - Pyrococcus horik... 522 e-147
gi|11498540 homoserine dehydrogenase (hom) [Archaeoglobus fulgid... 168 6e-41
pir||A64500 homoserine dehydrogenase (EC 1.1.1.3) - Methanococcu... 162 4e-39
dbj|BAB05456.1| (AP001513) homoserine dehydrogenase [Bacillus ha... 161 1e-38
pir||C69154 homoserine dehydrogenase homolog - Methanobacterium ... 137 2e-31
emb|CAB57645.1| (Y18930) hypothetical protein [Sulfolobus solfat... 136 3e-31
gb|AAK40962.1| Homoserine dehydrogenase (thrA/hom) [Sulfolobus s... 136 3e-31
dbj|BAB07141.1| (AP001518) homoserine dehydrogenase [Bacillus ha... 131 8e-30
sp|P19582|DHOM_BACSU HOMOSERINE DEHYDROGENASE (HDH) >gi|7427665|... 129 4e-29
gb|AAA50609.1| (M23217) homoserine dehydrogenase [Bacillus subti... 129 4e-29
sp|P52985|DHOM_LACLA HOMOSERINE DEHYDROGENASE (HDH) >gi|2117450|... 129 4e-29
pir||H72364 aspartokinase II - Thermotoga maritima (strain MSB8)... 128 7e-29
pir||C70456 homoserine dehydrogenase (EC 1.1.1.3) - Aquifex aeol... 124 1e-27
pir||A75415 homoserine dehydrogenase - Deinococcus radiodurans (... 122 5e-27
pir||F69031 homoserine dehydrogenase (EC 1.1.1.3) - Methanobacte... 120 2e-26
pir||H83179 homoserine dehydrogenase PA3736 [imported] - Pseudom... 116 3e-25
sp|P08499|DHOM_CORGL HOMOSERINE DEHYDROGENASE (HDH) >gi|65915|pi... 116 4e-25
dbj|BAB04972.1| (AP001511) homoserine dehydrogenase [Bacillus ha... 114 2e-24
gb|AAF21129.1|L78665_3 (L78665) homoserine dehydrogenase [Methyl... 113 4e-24
sp|Q9ZL20|DHOM_HELPJ HOMOSERINE DEHYDROGENASE (HDH) >gi|7431118|... 111 1e-23
sp|P52986|DHOM_SYNY3 HOMOSERINE DEHYDROGENASE (HDH) >gi|7431117|... 111 1e-23
sp|P56429|DHOM_HELPY HOMOSERINE DEHYDROGENASE (HDH) >gi|7431119|... 111 1e-23
gb|AAG20683.1| (AE005137) homoserine dehydrogenase; Hom [Halobac... 109 3e-23
pir||E81106 probable homoserine dehydrogenase (EC 1.1.1.3) NMA13... 109 3e-23
sp|P46806|DHOM_MYCLE HOMOSERINE DEHYDROGENASE (HDH) >gi|7431123|... 109 5e-23
gb|AAD32592.1|AF126720_3 (AF126720) homoserine dehydrogenase [My... 108 7e-23
pir||A72716 probable homoserine dehydrogenase APE1144 - Aeropyru... 106 4e-22
emb|CAC12304.1| (AL445066) homoserine dehydrogenase related prot... 106 4e-22
pir||T06246 aspartate kinase (EC 2.7.2.4) / homoserine dehydroge... 105 6e-22
sp|Q10601|DHOM_MYCTU HOMOSERINE DEHYDROGENASE (HDH) >gi|7431115|... 104 1e-21
pir||T06242 aspartate kinase (EC 2.7.2.4) / homoserine dehydroge... 102 5e-21
pir||E81432 homoserine dehydrogenase (EC 1.1.1.3) Cj0149c [impor... 101 1e-20
pir||S46497 aspartate kinase (EC 2.7.2.4) / homoserine dehydroge... 100 2e-20
pir||H82086 aspartokinase I/homoserine dehydrogenase, threonine-... 100 2e-20
gb|AAD21689.1| (AC004793) Identical to gb|X71364 gene for aspart... 100 3e-20
sp|P44505|AKH_HAEIN BIFUNCTIONAL ASPARTOKINASE/HOMOSERINE DEHYDR... 100 3e-20
sp|P49079|AKH1_MAIZE BIFUNCTIONAL ASPARTOKINASE/HOMOSERINE DEHYD... 98 1e-19
sp|P27725|AK1H_SERMA BIFUNCTIONAL ASPARTOKINASE/HOMOSERINE DEHYD... 96 5e-19
dbj|BAA38474.1| (D10385) aspartokinase I-homoserine dehydrogenas... 96 5e-19
dbj|BAA38480.1| (D10387) aspartokinase I-homoserine dehydrogenas... 96 5e-19
sp|P49080|AKH2_MAIZE BIFUNCTIONAL ASPARTOKINASE/HOMOSERINE DEHYD... 96 5e-19
dbj|BAA38477.1| (D10386) aspartokinase I-homoserine dehydrogenas... 94 2e-18
pir||DEECK thrA bifunctional enzyme - Escherichia coli >gi|53724... 90 4e-17
sp|P37142|AKH_DAUCA BIFUNCTIONAL ASPARTOKINASE/HOMOSERINE DEHYDR... 90 4e-17
pir||T04752 aspartate kinase (EC 2.7.2.4) / homoserine dehydroge... 88 1e-16
emb|CAA23660.1| (V00361) thrA gene [EC 2.7.2.4 and EC 1.1.1.3] [... 87 3e-16
sp|P00561|AK1H_ECOLI BIFUNCTIONAL ASPARTOKINASE/HOMOSERINE DEHYD... 87 3e-16
gi|6322599 Homoserine dehydrogenase (L-homoserine:NADP oxidoredu... 87 3e-16
pdb|1EBF|A Chain A, Homoserine Dehydrogenase From S. Cerevisiae ... 87 3e-16
sp|P57290|AKH_BUCAI BIFUNCTIONAL ASPARTOKINASE/HOMOSERINE DEHYDR... 85 8e-16
pir||T03589 probable aspartate kinase (EC 2.7.2.4) / homoserine ... 84 2e-15
pir||T40673 homoserine dehydrogenase - fission yeast (Schizosac... 84 2e-15
pir||G82583 bifunctional aspartokinase/homoserine dehydrogenase ... 83 5e-15
sp|P29365|DHOM_PSEAE HOMOSERINE DEHYDROGENASE (HDH) >gi|65916|pi... 80 3e-14
sp|P37144|DHON_METGL HOMOSERINE DEHYDROGENASE (HDH) >gi|2160268|... 80 4e-14
emb|CAB59717.1| (AL132707) putative homoserine dehydrogenase [St... 76 6e-13
>pir||F75138 homoserine dehydrogenase (hom) PAB0610 - Pyrococcus abyssi (strain
Orsay) >gi|5458334|emb|CAB49823.1| (AJ248285) homoserine
dehydrogenase (hom) [Pyrococcus abyssi]
Length = 318
Score = 627 bits (1599), Expect = e-179
Identities = 318/318 (100%), Positives = 318/318 (100%)
Query: 1 MKVKVSVFGFGTVGRALAEIIAEKRKVFGVELNVVSITDRSGTIWGDFDLLEAKEVKEST 60
MKVKVSVFGFGTVGRALAEIIAEKRKVFGVELNVVSITDRSGTIWGDFDLLEAKEVKEST
Sbjct: 1 MKVKVSVFGFGTVGRALAEIIAEKRKVFGVELNVVSITDRSGTIWGDFDLLEAKEVKEST 60
Query: 61 GKLSNIGEYEVYDFSPQELIEEVKPDILVDVSSWDDAHEMYSYALAEGISVVTSNKPPIA 120
GKLSNIGEYEVYDFSPQELIEEVKPDILVDVSSWDDAHEMYSYALAEGISVVTSNKPPIA
Sbjct: 61 GKLSNIGEYEVYDFSPQELIEEVKPDILVDVSSWDDAHEMYSYALAEGISVVTSNKPPIA 120
Query: 121 NHYDELITLARENGVGIFFESTVMAGTPIIGLLRENLLGEEIVKMEAIVNASTTFILTRM 180
NHYDELITLARENGVGIFFESTVMAGTPIIGLLRENLLGEEIVKMEAIVNASTTFILTRM
Sbjct: 121 NHYDELITLARENGVGIFFESTVMAGTPIIGLLRENLLGEEIVKMEAIVNASTTFILTRM 180
Query: 181 ENGKTFEEAMEEARTLGILEEDPSKDIDGIDAYYKAKILHWVSYGEQPEEEEREGIRNVK 240
ENGKTFEEAMEEARTLGILEEDPSKDIDGIDAYYKAKILHWVSYGEQPEEEEREGIRNVK
Sbjct: 181 ENGKTFEEAMEEARTLGILEEDPSKDIDGIDAYYKAKILHWVSYGEQPEEEEREGIRNVK 240
Query: 241 DARNVRLVAEISKGRISVAPRKLPDNSPLLVSEVENAALIKTENLTLTLKGPGGGGKVTA 300
DARNVRLVAEISKGRISVAPRKLPDNSPLLVSEVENAALIKTENLTLTLKGPGGGGKVTA
Sbjct: 241 DARNVRLVAEISKGRISVAPRKLPDNSPLLVSEVENAALIKTENLTLTLKGPGGGGKVTA 300
Query: 301 SGVFTDIIKAALKFPSPR 318
SGVFTDIIKAALKFPSPR
Sbjct: 301 SGVFTDIIKAALKFPSPR 318
>pir||H71101 probable homoserine dehydrogenase - Pyrococcus horikoshii
>gi|3257491|dbj|BAA30174.1| (AP000004) 319aa long
hypothetical homoserine dehydrogenase [Pyrococcus
horikoshii]
Length = 319
Score = 522 bits (1329), Expect = e-147
Identities = 256/319 (80%), Positives = 292/319 (91%), Gaps = 1/319 (0%)
Query: 1 MKVKVSVFGFGTVGRALAEIIAEKRKVFGVELNVVSITDRSGTIWGDFDLLEAKEVKEST 60
MKV +S+FGFGTVGRALAEIIAEK ++FGVELNV+SITDRSGTIWGDFDLLEAKEVKEST
Sbjct: 1 MKVNISIFGFGTVGRALAEIIAEKSRIFGVELNVISITDRSGTIWGDFDLLEAKEVKEST 60
Query: 61 GKLSNIGEYEVYDFSPQELIEEVKPDILVDVSSWDDAHEMYSYALAEGISVVTSNKPPIA 120
GKLSNIG+YEVY+FSPQEL+EEVKP+ILVDVSSWD+AHEMY AL EGISVVTSNKPPIA
Sbjct: 61 GKLSNIGDYEVYNFSPQELVEEVKPNILVDVSSWDEAHEMYKVALGEGISVVTSNKPPIA 120
Query: 121 NHYDELITLARENGVGIFFESTVMAGTPIIGLLRENLLGEEIVKMEAIVNASTTFILTRM 180
N+YDEL+ LA+EN GIFFESTVMAGTPIIG+LRENLLGE I +++A+VNASTTFILT+M
Sbjct: 121 NYYDELMNLAKENNAGIFFESTVMAGTPIIGVLRENLLGENIKRIDAVVNASTTFILTKM 180
Query: 181 ENGKTFEEAMEEARTLGILEEDPSKDIDGIDAYYKAKILHWVSYGEQPEEEEREGIRNVK 240
GKT ++A+EEA++LGILEEDPSKDIDGIDAYYKAKILHWVSYGE PEEEER GIR V+
Sbjct: 181 SEGKTLDDAIEEAKSLGILEEDPSKDIDGIDAYYKAKILHWVSYGEPPEEEERLGIREVR 240
Query: 241 DARNVRLVAEISKGRISVAPRKLPDNSPLLVSEVENAALIKTENL-TLTLKGPGGGGKVT 299
DARNVRLVA++SKG+ISV PRKL ++PLLV V+NAA+I+T NL + LKGPGGGG+VT
Sbjct: 241 DARNVRLVAQVSKGKISVKPRKLSSDNPLLVEGVQNAAVIRTNNLGEVILKGPGGGGRVT 300
Query: 300 ASGVFTDIIKAALKFPSPR 318
ASGVFTDIIKA LKFP+ R
Sbjct: 301 ASGVFTDIIKATLKFPNLR 319
>gi|11498540 homoserine dehydrogenase (hom) [Archaeoglobus fulgidus]
>gi|7431121|pir||G69366 homoserine dehydrogenase (hom)
homolog - Archaeoglobus fulgidus
>gi|2649661|gb|AAB90303.1| (AE001039) homoserine
dehydrogenase (hom) [Archaeoglobus fulgidus]
Length = 326
Score = 168 bits (422), Expect = 6e-41
Identities = 109/325 (33%), Positives = 177/325 (53%), Gaps = 28/325 (8%)
Query: 3 VKVSVFGFGTVGRALAEIIAEKR----KVFGVELNVVSITDRSGTIWGDFDLLEAKEVKE 58
+K+++ GFGTVG+ +AE++ KR K G E V ++ D +I GDF L+EA +K
Sbjct: 2 IKIAIVGFGTVGQGVAELLIRKREEIEKAIG-EFKVTAVADSKSSISGDFSLVEALRMKR 60
Query: 59 STGKLSNIGEYEVYDFSPQELIEEVKPDILVDVS-SWDDAHEMYSY---ALAEGISVVTS 114
TG L + D E++ D+L++ S + D E +Y AL G VVTS
Sbjct: 61 ETGMLRD-------DAKAIEVVRSADYDVLIEASVTRVDGGEGVNYIREALKRGKHVVTS 113
Query: 115 NKPPIANHYDELITLARENGVGIFFESTVMAGTPIIGLLRENLLGEEIVKMEAIVNASTT 174
NK P+ + L++LA NGV + +E+TV P++ L + L EI ++ I N +
Sbjct: 114 NKGPLVAEFHGLMSLAERNGVRLMYEATVGGAMPVVKLAKRYLALCEIESVKGIFNGTCN 173
Query: 175 FILTRMENGK-TFEEAMEEARTLGILEEDPSKDIDGIDAYYKAKIL-HWVSYGEQPEEEE 232
+IL+RME + +E ++EA+ LG E DPS D++GIDA K I+ + + E+ E
Sbjct: 174 YILSRMEEERLPYEHILKEAQELGYAEADPSYDVEGIDAALKLVIIANTIGVKASYEDVE 233
Query: 233 REGIRNV---------KDARNVRLVAEISKGRISVAPRKLPDNSPLLVSEVENAALIKTE 283
GI + + +RL+AE+S+ ++ V+PR +P + PL + NAA+ KT+
Sbjct: 234 VTGITQITPEAFQVAAEKGYTIRLIAEVSREKLKVSPRLVPFHHPLAIKGTMNAAMFKTD 293
Query: 284 NL-TLTLKGPGGGGKVTASGVFTDI 307
++ + G G G + TAS + +D+
Sbjct: 294 TAGSIFVAGRGAGKEETASAILSDL 318
>pir||A64500 homoserine dehydrogenase (EC 1.1.1.3) - Methanococcus jannaschii
>gi|1500499|gb|AAB99622.1| (U67600) homoserine
dehydrogenase (hom) [Methanococcus jannaschii]
Length = 336
Score = 162 bits (407), Expect = 4e-39
Identities = 113/327 (34%), Positives = 181/327 (54%), Gaps = 24/327 (7%)
Query: 5 VSVFGFGTVGRALAEIIAEKR---KVFGVELNVVSITDRSGTIWGD--FDLLEAKEVKES 59
+ + GFG +G+ +A+++ +K+ K E VV+ITD SG + DLL+A EVKE
Sbjct: 3 IIIVGFGAIGKGIAKVLYDKKDYLKKNYEEFKVVAITDSSGAAIDEDGLDLLKAIEVKEK 62
Query: 60 TGKLSNIGEYEVYDFSPQELIEEVKPDILVDVS-----SWDDAHEMYSYALAEGISVVTS 114
TGK+ N E + + S ++I+EV D++V+V+ + D A + VVT+
Sbjct: 63 TGKIKNYPE-KGREMSSIDVIKEVDADVVVEVTPSNLETGDPAKTHILESFKNKKHVVTA 121
Query: 115 NKPPIANHYDELITLARENGVGIFFESTVMAGTPIIGLLRENLLGEEIVKMEAIVNASTT 174
NK P+A Y ELI A+++GV E++V PII L +E L G EI+ + I+N +T
Sbjct: 122 NKGPLALCYKELIEEAKKHGVIFRHEASVGGAMPIINLAKETLAGNEILSIRGILNGTTN 181
Query: 175 FILTRME-NGKTFEEAMEEARTLGILEEDPSKDIDGIDAYYKAKIL--HWVSYGEQPEEE 231
+ILT+ME G FE A++EA+ LGI E DP++DI+G+D K IL + + ++
Sbjct: 182 YILTKMEKEGLDFETALKEAKELGIAETDPTQDIEGLDTAAKIVILANSIMGMNKTIKDV 241
Query: 232 EREGIRNV---------KDARNVRLVAEISKGRISVAPRKLPDNSPLLVSEVENAALIKT 282
+ +GI + K ++L+ +I G + V P +P +SPL V N A+ +T
Sbjct: 242 KVKGISRITPEALFLANKRGYTIKLIGQIKDGYLIVEPMLVPIDSPLNVKGTLNVAMFET 301
Query: 283 E-NLTLTLKGPGGGGKVTASGVFTDII 308
+ + + G G G TAS + +D+I
Sbjct: 302 DLAKEVVVVGRGAGPIETASAILSDLI 328
>dbj|BAB05456.1| (AP001513) homoserine dehydrogenase [Bacillus halodurans]
Length = 342
Score = 161 bits (402), Expect = 1e-38
Identities = 116/335 (34%), Positives = 176/335 (51%), Gaps = 27/335 (8%)
Query: 1 MKVKVSVFGFGTVGRALAEIIAEKRKVFGVELNVVSITD-RSGTIW--GDFDLLEAKEVK 57
M KV++ GFG V + +I+ E+ + + VVSITD R G + DL ++
Sbjct: 1 MTQKVALIGFGGVAQGFIQILRERGEELPEHIQVVSITDWRRGAVHDPNGLDLDFIAKII 60
Query: 58 ESTGKLSNIGEYE--VYDFSPQELIEEVKPDILVDVSSWD-----DAHEMYSYALAEGIS 110
E+ G + E + ++ E I++ D +V+V+ D A + AL G
Sbjct: 61 ETDGTFEHYPERSGVIKGWNSFETIQQTNADTIVEVTFTDVLTGQPAIDHCKEALRLGKH 120
Query: 111 VVTSNKPPIANHYDELITLARENGVGIFFESTVMAGTPIIGLLRENLLGEEIVKMEAIVN 170
VVT+NK PIA Y EL LA NGV + +E TVM+GTP + L L+G I +++ I+N
Sbjct: 121 VVTTNKGPIAVAYQELKELADANGVQLLYEGTVMSGTPALRLPEHTLIGNNIQEVKGILN 180
Query: 171 ASTTFILTRMENGKTFEEAMEEARTLGILEEDPSKDIDGIDAYYKAKILHWVSYG--EQP 228
+T +ILT ME GKTFE+A+++A+TLG E DP+ D++G D YK IL V G +P
Sbjct: 181 GTTNYILTEMERGKTFEQALQDAQTLGYAEADPTSDVEGYDVLYKVVILANVMMGIPLKP 240
Query: 229 EEEEREGI-----RNVKDARNV--------RLVAEISKGRISVAPRKLPDNSPLL-VSEV 274
+ ER GI R++KDA + R+ E + +V P +LP PL ++
Sbjct: 241 SDVERVGISHLTPRDIKDAHSAGERWKLIGRVKKEGERTMATVRPERLPLTDPLANINGA 300
Query: 275 ENAALIKTE-NLTLTLKGPGGGGKVTASGVFTDII 308
NA + + + +TL G G G K T + D++
Sbjct: 301 INAITYECDISGPITLIGAGAGVKETGFALLIDLL 335
>pir||C69154 homoserine dehydrogenase homolog - Methanobacterium
thermoautotrophicum (strain Delta H)
>gi|2621481|gb|AAB84923.1| (AE000826) homoserine
dehydrogenase homolog [Methanobacterium
thermoautotrophicum]
Length = 340
Score = 137 bits (341), Expect = 2e-31
Identities = 103/330 (31%), Positives = 162/330 (48%), Gaps = 26/330 (7%)
Query: 3 VKVSVFGFGTVGRALAEIIAEK----RKVFGVELNVVSITDRSGTIWGD--FDLLEAKEV 56
+++ + G G VG+ + K R+ +G+++ + D SG + D+ E
Sbjct: 4 MRICLVGLGAVGQGFLRAVQMKGEYLRERYGLDIRFTGVADSSGALHDPDGLDIRGVLEH 63
Query: 57 KESTGKLSNIGEYEVYDFSPQELIEEVKPDILVD-----VSSWDDAHEMYSYALAEGISV 111
K+ G S+ YE + EL++E + D LV+ + + + A+ +G V
Sbjct: 64 KKRAGLGSHPSGYE--GMTGDELLDEAEYDCLVEATPTNIEDGEPGRSLVLKAMGDGKHV 121
Query: 112 VTSNKPPIANHYDELITLARENGVGIFFESTVMAGTPIIGLLRENLLGEEIVKMEAIVNA 171
VTSNK +A Y EL+ A E GV FE++V PII L RE L I + I+N
Sbjct: 122 VTSNKGHLALFYSELMEAASEAGVEFMFEASVGGAMPIINLARETLASCTIESVIGILNG 181
Query: 172 STTFILTRM-ENGKTFEEAMEEARTLGILEEDPSKDIDGIDAYYKAKILHWVSYGE--QP 228
+T FIL+RM G ++ +A+ EA+ LGI E +P++D++G DA KA I+ G
Sbjct: 182 TTNFILSRMASEGSSYRQALIEAQELGIAETNPAQDVEGTDAACKAVIIANSILGRPCTL 241
Query: 229 EEEEREGIRNV---------KDARNVRLVAEISKGRISVAPRKLPDNSPLLVSEVENAAL 279
+ EGI + ++ ++L+AEIS R+ V PR + SP V N A
Sbjct: 242 RDVRVEGITGITQGAIELAAQEGYLIKLIAEISGDRLEVGPRLVRMGSPYAVDGTLNMAT 301
Query: 280 IKTENL-TLTLKGPGGGGKVTASGVFTDII 308
++T+ +T G G G TAS + TD I
Sbjct: 302 LRTDLAGEVTAVGRGAGSLETASAMLTDTI 331
>emb|CAB57645.1| (Y18930) hypothetical protein [Sulfolobus solfataricus]
Length = 314
Score = 136 bits (339), Expect = 3e-31
Identities = 97/325 (29%), Positives = 162/325 (49%), Gaps = 37/325 (11%)
Query: 3 VKVSVFGFGTVGRALAEIIAEKRKVFGV--ELNVVSITDRSGTIWGDFDLLEAKEVKEST 60
+K+ + G+G VG+A ++ EK+ + + + + I R G + GD KE+
Sbjct: 1 MKLLLIGYGNVGKAFRRLLHEKKDNYPILQGVEIAGIITRQGLMVGD---------KENF 51
Query: 61 GKLSNIGEYEVYDFSPQELIEEVKPDILVDVS-----SWDDAHEMYSYALAEGISVVTSN 115
+ E D+ + PD++VD+S + + Y AL+ I V+T N
Sbjct: 52 SPDKQLTVLEAIDY--------INPDVIVDMSVPNYKDGEPSVSAYIKALSRKIHVITVN 103
Query: 116 KPPIANHYDELITLARENGVGIFFESTVMAGTPIIGLLRENLLGEEIVKMEAIVNASTTF 175
K P+A + E+ +A + G I F+ TVM+GTP I L R + E + ++ I+N +T +
Sbjct: 104 KAPLALKFREIFEVAEKTGAKIGFQGTVMSGTPSINLFRIQPVAE-VSRIRGILNGTTNY 162
Query: 176 ILTRMENGKTFEEAMEEARTLGILEEDPSKDIDGIDAYYKAKIL------HWVSYGEQP- 228
ILTR+ G +F EA++EA+ G EEDP+ D++G DA K IL + G+
Sbjct: 163 ILTRIYEGLSFNEALKEAKEKGYAEEDPTLDLNGFDAAAKLTILSNFIMNRSLKLGDFKF 222
Query: 229 ---EEEEREGIRNVK-DARNVRLVAEISKGRISVAPRKLPDNSPL-LVSEVENAALIKTE 283
E E IR K + + ++L+A + V+P+ + PL + VENA I+ E
Sbjct: 223 KGITEITNEEIRRAKSEGKKIKLIAYADNYVVQVSPQIIGPQDPLYYIDGVENALEIQNE 282
Query: 284 NLTLTLKGPGGGGKVTASGVFTDII 308
+ ++GPG G A G +D++
Sbjct: 283 IQRIIIRGPGAGPINAAYGALSDLV 307
>gb|AAK40962.1| Homoserine dehydrogenase (thrA/hom) [Sulfolobus solfataricus]
Length = 314
Score = 136 bits (339), Expect = 3e-31
Identities = 97/325 (29%), Positives = 162/325 (49%), Gaps = 37/325 (11%)
Query: 3 VKVSVFGFGTVGRALAEIIAEKRKVFGV--ELNVVSITDRSGTIWGDFDLLEAKEVKEST 60
+K+ + G+G VG+A ++ EK+ + + + + I R G + GD KE+
Sbjct: 1 MKLLLIGYGNVGKAFRRLLHEKKDNYPILQGVEIAGIITRQGLMVGD---------KENF 51
Query: 61 GKLSNIGEYEVYDFSPQELIEEVKPDILVDVS-----SWDDAHEMYSYALAEGISVVTSN 115
+ E D+ + PD++VD+S + + Y AL+ I V+T N
Sbjct: 52 SPDKQLTVLEAIDY--------INPDVIVDMSVPNYKDGEPSVSAYIKALSRKIHVITVN 103
Query: 116 KPPIANHYDELITLARENGVGIFFESTVMAGTPIIGLLRENLLGEEIVKMEAIVNASTTF 175
K P+A + E+ +A + G I F+ TVM+GTP I L R + E + ++ I+N +T +
Sbjct: 104 KAPLALKFREIFEVAEKTGAKIGFQGTVMSGTPSINLFRIQPVAE-VSRIRGILNGTTNY 162
Query: 176 ILTRMENGKTFEEAMEEARTLGILEEDPSKDIDGIDAYYKAKIL------HWVSYGEQP- 228
ILTR+ G +F EA++EA+ G EEDP+ D++G DA K IL + G+
Sbjct: 163 ILTRIYEGLSFNEALKEAKEKGYAEEDPTLDLNGFDAAAKLTILSNFIMNRSLKLGDFKF 222
Query: 229 ---EEEEREGIRNVK-DARNVRLVAEISKGRISVAPRKLPDNSPL-LVSEVENAALIKTE 283
E E IR K + + ++L+A + V+P+ + PL + VENA I+ E
Sbjct: 223 KGITEITNEEIRRAKSEGKKIKLIAYADNYVVQVSPQIIGPQDPLYYIDGVENALEIQNE 282
Query: 284 NLTLTLKGPGGGGKVTASGVFTDII 308
+ ++GPG G A G +D++
Sbjct: 283 IQRIIIRGPGAGPINAAYGALSDLV 307
>dbj|BAB07141.1| (AP001518) homoserine dehydrogenase [Bacillus halodurans]
Length = 431
Score = 131 bits (327), Expect = 8e-30
Identities = 103/329 (31%), Positives = 164/329 (49%), Gaps = 40/329 (12%)
Query: 3 VKVSVFGFGTVGRALAEIIA----EKRKVFGVELNVVSITDRSGTIWGDFDLLEAKEVKE 58
+KV + G GTVG + ++I E R G+ + V + R D +A++V
Sbjct: 5 LKVGLLGLGTVGSGVVKLIENHQQELRHQIGLPVQVEKVLVR--------DRSKARDVVL 56
Query: 59 STGKLSNIGEYEVYDFSPQELIEEVKPDILVDVSSWDD-AHEMYSYALAEGISVVTSNKP 117
S ++ GE E++E D++++V A E AL G VVT+NK
Sbjct: 57 SEESVTLYGE---------EIVENANIDVVIEVMGGITLAKEYIVRALKNGKHVVTANKD 107
Query: 118 PIANHYDELITLARENGVGIFFESTVMAGTPIIGLLRENLLGEEIVKMEAIVNASTTFIL 177
+A H EL++LA ENG +F+E++V G PII L + L + I KM IVN +T +IL
Sbjct: 108 LMAVHGAELLSLAAENGCDLFYEASVAGGIPIIRSLTDGLAADRITKMMGIVNGTTNYIL 167
Query: 178 TRM-ENGKTFEEAMEEARTLGILEEDPSKDIDGIDAYYKAKILHWVSYGEQPEEEE--RE 234
T+M + G +EE + +A+ LG E DP+ D++G+DA K IL + + E ++
Sbjct: 168 TKMTKEGLDYEEVLAQAQALGFAESDPTADVEGLDAARKMAILATLGFSMDVELDDVVVR 227
Query: 235 GIRNVKD---------ARNVRLVA----EISKGRISVAPRKLPDNSPL-LVSEVENAALI 280
GI +V ++L+ + + +SV P LP PL V++ NA +
Sbjct: 228 GISSVTKTDLEYCEQLGYTMKLIGLADRDGDRVEVSVQPTLLPKEHPLAAVNDEYNAVYV 287
Query: 281 KTENLTLTL-KGPGGGGKVTASGVFTDII 308
E + T+ GPG G TA+ V +D++
Sbjct: 288 YGEAVGETMFYGPGAGSLPTATAVVSDLV 316
>sp|P19582|DHOM_BACSU HOMOSERINE DEHYDROGENASE (HDH) >gi|7427665|pir||DEECHS homoserine
dehydrogenase (EC 1.1.1.3) - Bacillus subtilis
>gi|2635723|emb|CAB15216.1| (Z99120) homoserine
dehydrogenase [Bacillus subtilis]
Length = 433
Score = 129 bits (321), Expect = 4e-29
Identities = 103/329 (31%), Positives = 166/329 (50%), Gaps = 40/329 (12%)
Query: 3 VKVSVFGFGTVGRALAEIIAEKRKVF----GVELNVVSITDRSGTIWGDFDLLEAKEVKE 58
++V + G GTVG + +II + + G + + + + DL + +EV
Sbjct: 4 IRVGLLGLGTVGSGVVKIIQDHQDKLMHQVGCPVTIKKVLVK--------DLEKKREVDL 55
Query: 59 STGKLSNIGEYEVYDFSPQELIEEVKPDILVDVSSWDDAHEMYSY-ALAEGISVVTSNKP 117
L+ EVYD +I++ D++++V + + Y AL VVT+NK
Sbjct: 56 PKEVLTT----EVYD-----VIDDPDVDVVIEVIGGVEQTKQYLVDALRSKKHVVTANKD 106
Query: 118 PIANHYDELITLARENGVGIFFESTVMAGTPIIGLLRENLLGEEIVKMEAIVNASTTFIL 177
+A + EL+ A+ENG I+FE++V G PI+ L E L + I KM IVN +T FIL
Sbjct: 107 LMAVYGSELLAEAKENGCDIYFEASVAGGIPILRTLEEGLSSDRITKMMGIVNGTTNFIL 166
Query: 178 TRMENGKT-FEEAMEEARTLGILEEDPSKDIDGIDAYYKAKILHWVSYGEQP--EEEERE 234
T+M K+ +EE ++EA+ LG E DP+ D++G+DA K IL + + E+ + +
Sbjct: 167 TKMIKEKSPYEEVLKEAQDLGFAEADPTSDVEGLDAARKMAILARLGFSMNVDLEDVKVK 226
Query: 235 GIRNVKD---------ARNVRLVA----EISKGRISVAPRKLPDNSPLLVSEVE-NAALI 280
GI + D ++L+ + SK +SV P LPD+ PL E NA +
Sbjct: 227 GISQITDEDISFSKRLGYTMKLIGIAQRDGSKIEVSVQPTLLPDHHPLSAVHNEFNAVYV 286
Query: 281 KTENLTLTL-KGPGGGGKVTASGVFTDII 308
E + T+ GPG G TA+ V +D++
Sbjct: 287 YGEAVGETMFYGPGAGSMPTATSVVSDLV 315
>gb|AAA50609.1| (M23217) homoserine dehydrogenase [Bacillus subtilis]
Length = 433
Score = 129 bits (321), Expect = 4e-29
Identities = 103/329 (31%), Positives = 166/329 (50%), Gaps = 40/329 (12%)
Query: 3 VKVSVFGFGTVGRALAEIIAEKRKVF----GVELNVVSITDRSGTIWGDFDLLEAKEVKE 58
++V + G GTVG + +II + + G + + + + DL + +EV
Sbjct: 4 IRVGLLGLGTVGSGVVKIIQDHQDKLMHQVGCPVTIKKVLVK--------DLEKKREVDL 55
Query: 59 STGKLSNIGEYEVYDFSPQELIEEVKPDILVDVSSWDDAHEMYSY-ALAEGISVVTSNKP 117
L+ EVYD +I++ D++++V + + Y AL VVT+NK
Sbjct: 56 PKEVLTT----EVYD-----VIDDPDVDVVIEVIGGVEQTKQYLVDALRSKKHVVTANKD 106
Query: 118 PIANHYDELITLARENGVGIFFESTVMAGTPIIGLLRENLLGEEIVKMEAIVNASTTFIL 177
+A + EL+ A+ENG I+FE++V G PI+ L E L + I KM IVN +T FIL
Sbjct: 107 LMAVYGSELLAEAKENGCDIYFEASVAGGIPILRTLEEGLSSDRITKMMGIVNGTTNFIL 166
Query: 178 TRMENGKT-FEEAMEEARTLGILEEDPSKDIDGIDAYYKAKILHWVSYGEQP--EEEERE 234
T+M K+ +EE ++EA+ LG E DP+ D++G+DA K IL + + E+ + +
Sbjct: 167 TKMIKEKSPYEEVLKEAQDLGFAEADPTSDVEGLDAARKMAILARLGFSMNVDLEDVKVK 226
Query: 235 GIRNVKD---------ARNVRLVA----EISKGRISVAPRKLPDNSPLLVSEVE-NAALI 280
GI + D ++L+ + SK +SV P LPD+ PL E NA +
Sbjct: 227 GISQITDEDISFSKRLGYTMKLIGIAQRDGSKIEVSVQPTLLPDHHPLSAVHNEFNAVYV 286
Query: 281 KTENLTLTL-KGPGGGGKVTASGVFTDII 308
E + T+ GPG G TA+ V +D++
Sbjct: 287 YGEAVGETMFYGPGAGSMPTATSVVSDLV 315
>sp|P52985|DHOM_LACLA HOMOSERINE DEHYDROGENASE (HDH) >gi|2117450|pir||JC6049 homoserine
dehydrogenase (EC 1.1.1.3) - Lactococcus lactis
>gi|1255939|emb|CAA65713.1| (X96988) hom [Lactococcus
lactis]
Length = 428
Score = 129 bits (321), Expect = 4e-29
Identities = 95/334 (28%), Positives = 176/334 (52%), Gaps = 42/334 (12%)
Query: 1 MKVKVSVFGFGTVGRALAEIIAEKR----KVFGVELNVVSITDRSGTIWGDFDLLEAKEV 56
M V +++ GFGTVG L +++E + K+ E+ + + R K +
Sbjct: 1 MAVNIAILGFGTVGTGLPTLLSENKEKLAKILDEEIVISKVLMRDN-----------KAI 49
Query: 57 KESTGKLSNIGEYEVYDF--SPQELIEEVKPDILVDVSSWDDAHEMY-SYALAEGISVVT 113
+++ + N YDF + +++ + + I+V++ + + Y + A+ G +VVT
Sbjct: 50 EKARSQGFN------YDFVLNLDDILADSEISIVVELMGRIEPAKTYITQAIEAGKNVVT 103
Query: 114 SNKPPIANHYDELITLARENGVGIFFESTVMAGTPIIGLLRENLLGEEIVKMEAIVNAST 173
+NK +A H EL +LA+++ V +++E+ V G PI+ L + ++I + I+N ++
Sbjct: 104 ANKDLLAVHGVELRSLAQKHHVALYYEAAVAGGIPILRTLANSFSSDKITHLLGILNGTS 163
Query: 174 TFILTRM-ENGKTFEEAMEEARTLGILEEDPSKDIDGIDAYYKAKILHWVSYGE--QPEE 230
F++T+M E G T++E++ +A+ LG E DP+ D+DGIDA YK IL ++G P++
Sbjct: 164 NFMMTKMSEEGWTYDESLAKAQELGYAESDPTNDVDGIDASYKLAILSEFAFGMTLAPDD 223
Query: 231 EEREGIRNVKD---------ARNVRLVAEISKGR----ISVAPRKLPDNSPLL-VSEVEN 276
+ G+R+++ ++L EI++ V+P LP + PL V+ V N
Sbjct: 224 IAKSGLRSIQKTDVEIAQQFGYVLKLTGEINEVDSGIFAEVSPTFLPKSHPLASVNGVMN 283
Query: 277 AALIKTENL-TLTLKGPGGGGKVTASGVFTDIIK 309
A I++E + G G G K TA+ V DI++
Sbjct: 284 AVFIESEGIGDSVFYGAGAGQKPTATSVLADIVR 317
>pir||H72364 aspartokinase II - Thermotoga maritima (strain MSB8)
>gi|4981061|gb|AAD35632.1|AE001729_12 (AE001729)
aspartokinase II [Thermotoga maritima]
Length = 739
Score = 128 bits (319), Expect = 7e-29
Identities = 103/329 (31%), Positives = 162/329 (48%), Gaps = 39/329 (11%)
Query: 2 KVKVSVFGFGTVGRALAEIIAEKRKVFGVELNVVSITDRSGTIWGDFDLLEAKEVKESTG 61
KV+V + G GTVG ++ I+ E+ I R G + +K + S
Sbjct: 19 KVRVGIAGLGTVGGSIYRILKERGN---------EIEKRIGE-----KFIISKVINRSPQ 64
Query: 62 KLSNIG---EYEVYDFSPQELIEEVKPDILVD-VSSWDDAHEMYSYALAEGISVVTSNKP 117
K +G E +DF +LI + D++V+ + D A ++ AL G VVT NK
Sbjct: 65 KYELLGVPKEEIAFDFD--DLI--LNSDVVVEAIGGTDVAVDLVRRALELGRIVVTPNKN 120
Query: 118 PIANHYDELITLARENGVGIFFESTVMAGTPIIGLLRENLLGEEIVKMEAIVNASTTFIL 177
I+ + +E ++ +FFE++V G PII LL++ L+ +++ ++ I+N +T +IL
Sbjct: 121 LISEYGNEFSEYIKKRK--LFFEASVGGGIPIISLLQDYLIFQKVTRIRGIMNGTTNYIL 178
Query: 178 TRMENGKTFEEAMEEARTLGILEEDPSKDIDGIDAYYKAKILHWVSYGEQP--EEEEREG 235
T M G+ FEE ++EA+ LG E DP+ DI+G D YK +L V G P + EG
Sbjct: 179 TEMSKGRHFEEVLKEAQELGYAEADPTNDIEGYDVAYKVSVLAGVVTGRFPGINSVQFEG 238
Query: 236 IRN---------VKDARNVRLVAEI--SKGRISVAPRKLPDNSPLL-VSEVENAALIKTE 283
I V+ + ++L+ E+ S R V R++ P V V+NA + T+
Sbjct: 239 ITRIDPEYLKEIVRSGKKLKLIGELDFSTNRYEVRLREVTPEDPFFNVDGVDNAIEVSTD 298
Query: 284 NL-TLTLKGPGGGGKVTASGVFTDIIKAA 311
LKG G GG TAS V D+ + A
Sbjct: 299 LAGDFLLKGRGAGGYPTASAVIADLFRVA 327
>pir||C70456 homoserine dehydrogenase (EC 1.1.1.3) - Aquifex aeolicus
>gi|2984093|gb|AAC07631.1| (AE000757) homoserine
dehydrogenase [Aquifex aeolicus]
Length = 435
Score = 124 bits (309), Expect = 1e-27
Identities = 110/332 (33%), Positives = 165/332 (49%), Gaps = 44/332 (13%)
Query: 3 VKVSVFGFGTVGRALAEIIAEK----RKVFGVELNVVSITDRSGTIWGDFDLLEAKEVKE 58
V+V + G GTVG A+++ + +K G+E +V + D +F++ KE++
Sbjct: 4 VRVGIIGCGTVGTGTAKLLIQNADLIKKKTGIEFKLVKVADIDWERKREFEV--PKELRT 61
Query: 59 STGKLSNIGEYEVYDFSPQELIEEVKPDILVD-VSSWDDAHEMYSYALAEGISVVTSNKP 117
+ K EV D S D++V+ V A ++ AL G VVT+NK
Sbjct: 62 TDYK-------EVIDNS----------DVVVELVGGKTFAKKVILEALEAGKCVVTANKH 104
Query: 118 PIANHYDELITLARENGVGIFFESTVMAGTPIIGLLRENLLGEEIVKMEAIVNASTTFIL 177
+A E+ A++ + I FE++V G P+I LRE L G +I+ + I+N +T +IL
Sbjct: 105 LLAEEGKEIFEEAKKRNLFIGFEASVGGGIPVIKALREGLAGNKILNILGILNGTTNYIL 164
Query: 178 TRM-ENGKTFEEAMEEARTLGILEEDPSKDIDGIDAYYKAKILHWVSYGEQPEEEE--RE 234
TRM E FE A++EA+ G E DPS DIDG DA +K IL ++YG + + E
Sbjct: 165 TRMFEENLDFETALKEAKEKGYAEADPSLDIDGWDAAHKIAILAMLAYGGYLDFNDVYVE 224
Query: 235 GIRNVKDARNVRLVAEI--------------SKGRISVAPRKLPDNSPLL-VSEVENAAL 279
GIRNV D +V L E+ S+ + V P + L VS V NA +
Sbjct: 225 GIRNV-DKLDVELGKELGYTLKLLAIAKKVDSEVEVRVHPTFIHSEEALAKVSGVYNAVM 283
Query: 280 IKTENLTLTL-KGPGGGGKVTASGVFTDIIKA 310
I+ + + T+ G G G TAS V D+I A
Sbjct: 284 IEGDFVGKTMFYGQGAGSHPTASAVVADVIDA 315
>pir||A75415 homoserine dehydrogenase - Deinococcus radiodurans (strain R1)
>gi|6459026|gb|AAF10850.1|AE001975_4 (AE001975)
homoserine dehydrogenase [Deinococcus radiodurans]
Length = 325
Score = 122 bits (303), Expect = 5e-27
Identities = 98/338 (28%), Positives = 165/338 (47%), Gaps = 47/338 (13%)
Query: 3 VKVSVFGFGTVGRALAEIIAEKRKVFG---VELNVVSITDRSGTIWGDFDLLEAKEVKES 59
V V V G GTVG+ + ++I +R VFG V++ + + R D+ +A+E+
Sbjct: 4 VTVGVLGSGTVGQNVLQLIERRRPVFGDLGVQIELAGVLVR--------DVNKARELPAG 55
Query: 60 TGKLSNIGEYEVYDFSPQELIEEVKPDILVDVSSWDDAHEMYSYALAEGISVVTSNKPPI 119
N + ++E ++ + + E+ L G V+T+NK +
Sbjct: 56 VRVTDNC-----------DFLQECGV-VIEAMGGIERPLELLRPYLKSGRPVITANKALL 103
Query: 120 ANHYDELITLARENGVGIFFESTVMAGTPIIGLLRENLLGEEIVKMEAIVNASTTFILTR 179
A +DEL + A + +++E++VMAGTP+IG + L +++A++N + +ILT+
Sbjct: 104 AEKWDELRSYALDGD--LYYEASVMAGTPVIGPMSTVLRASTFTRLQAVLNGTCNYILTQ 161
Query: 180 MENGKTFEEAMEEARTLGILEEDPSKDIDGIDAYYKAKIL-HWVSYGEQPEEE-EREGIR 237
ME GK + A+ EA+ LG E+ P+ D+ G D +K +L + + G P E+ E +GI
Sbjct: 162 MEGGKDYAAALAEAQALGYAEDPPTLDVGGFDTAHKLAVLARFCADGNFPYEQIEVQGIE 221
Query: 238 NV---------KDARNVRLVAEISK---------GRISVAPRKLPDNSPL-LVSEVENAA 278
+V + ++LVAE+ + R VAP+ LP + PL NA
Sbjct: 222 HVTLDDIEQARQRGERLKLVAELRREGHDTQRGGWRAVVAPQSLPADHPLCXAGGGRNAM 281
Query: 279 LIKTENL-TLTLKGPGGGGKVTASGVFTDIIKAALKFP 315
+ + E L G G GG VTAS + D++ L FP
Sbjct: 282 VYEGEECGPLIFAGGGAGGMVTASAMVGDLLDYLLGFP 319
>pir||F69031 homoserine dehydrogenase (EC 1.1.1.3) - Methanobacterium
thermoautotrophicum (strain Delta H)
>gi|2622343|gb|AAB85721.1| (AE000890) homoserine
dehydrogenase [Methanobacterium thermoautotrophicum]
Length = 423
Score = 120 bits (298), Expect = 2e-26
Identities = 97/335 (28%), Positives = 164/335 (48%), Gaps = 43/335 (12%)
Query: 3 VKVSVFGFGTVGRALAEIIAEKRKVF----GVELNVVSITDRSGTIWGDFDLLEAKEVKE 58
+ + + GFGT+G + EI + G+EL + + D D+ + V+
Sbjct: 1 MNIGLIGFGTIGAGVVEIFNTNPDIIMKKTGMELRLRRVVD--------LDIETDRGVEI 52
Query: 59 STGKLSNIGEYEVYDFSPQELIEEVKPDILVD-VSSWDDAHEMYSYALAEGISVVTSNKP 117
G LS + +++E+ + DI+++ + ++ A A+ G VVT+NK
Sbjct: 53 DPGILSTDAD---------DILEDPEIDIVIELIGGYEPARSFILKAIENGKHVVTANKA 103
Query: 118 PIANHYDELITLARENGVGIFFESTVMAGTPIIGLLRENLLGEEIVKMEAIVNASTTFIL 177
+A H+DE++ ARE+GV + FE++V G P++ L E+L I + I+N + +IL
Sbjct: 104 LLARHWDEIMDAAREHGVRVAFEASVGGGIPVLRALNESLAANRIESIYGIINGTANYIL 163
Query: 178 TRM-ENGKTFEEAMEEARTLGILEEDPSKDIDGIDAYYKAKILHWVSYGEQPEEEER--E 234
TRM G F++ + EA+ LG E DP+ DI+G D K IL + +G E+E E
Sbjct: 164 TRMASEGMEFDDVLREAQRLGYAERDPTFDIEGHDTAQKLIILTLLGFGVHVPEDELHVE 223
Query: 235 GIRNVKD----------ARNVRLV--AEISKG--RISVAPRKLPDNSPL-LVSEVENAAL 279
GI +++ +V+L+ A ++ G + V P +P + L V+ V N
Sbjct: 224 GISSIRRDDIEYATAELGCSVKLLATARLNDGELELGVTPTLVPHHHLLSSVNGVFNGIY 283
Query: 280 IKTENLT--LTLKGPGGGGKVTASGVFTDIIKAAL 312
I T + T + G G G + TAS V D + A+
Sbjct: 284 I-TGDFTGPVMFYGKGAGRRATASAVVADCMDIAV 317
>pir||H83179 homoserine dehydrogenase PA3736 [imported] - Pseudomonas aeruginosa
(strain PAO1) >gi|9949903|gb|AAG07123.1|AE004792_8
(AE004792) homoserine dehydrogenase [Pseudomonas
aeruginosa]
Length = 434
Score = 116 bits (288), Expect = 3e-25
Identities = 100/325 (30%), Positives = 158/325 (47%), Gaps = 34/325 (10%)
Query: 3 VKVSVFGFGTVGRALAEIIAEKRKVFGVELNVVSITDRSGTIWGDFDLLEAKEVKESTGK 62
VKV + G GTVG ++ E N I R+G + + A+
Sbjct: 4 VKVGICGLGTVGGGTFNVL---------ERNAEEIARRAGR-GIEVAQIAARRPNPKCDT 53
Query: 63 LSNIGEYEVYDFSPQELIEEVKPDILVD-VSSWDDAHEMYSYALAEGISVVTSNKPPIAN 121
+ +++D + I D++V+ + + AHE+ A+ G VVT+NK IA
Sbjct: 54 GATPITADIFDVACNPEI-----DVVVELIGGYTLAHELVLKAIENGKHVVTANKALIAV 108
Query: 122 HYDELITLARENGVGIFFESTVMAGTPIIGLLRENLLGEEIVKMEAIVNASTTFILTRM- 180
H +E+ ARE GV + FE+ V G P+I +RE L I + I+N + FIL+ M
Sbjct: 109 HGNEIFAKAREKGVIVAFEAAVAGGIPVIKAIREGLSANRINWLAGIINGTGNFILSEMR 168
Query: 181 ENGKTFEEAMEEARTLGILEEDPSKDIDGIDAYYKAKILHWVSYG--EQPEEEEREGIR- 237
E G+TF + + EA+ LG E DP+ D++GIDA +K IL +++G Q ++ EGI
Sbjct: 169 EKGRTFPDVLAEAQALGYAEADPTFDVEGIDAAHKLTILASIAFGIPLQFDKAYTEGISK 228
Query: 238 ------NVKDARNVRL----VAEISKG--RISVAPRKLPDNSPLL-VSEVENAALIKTEN 284
N DA R+ VA ++ + V P +P + + V+ V NA ++ +
Sbjct: 229 LTSADVNYADALGYRIKHLGVARRTESGFELRVHPTLIPSDRLIANVNGVMNAVMVNGDA 288
Query: 285 LTLTL-KGPGGGGKVTASGVFTDII 308
+ TL G G G + TAS V D++
Sbjct: 289 VGSTLYYGAGAGMEPTASSVVADLV 313
>sp|P08499|DHOM_CORGL HOMOSERINE DEHYDROGENASE (HDH) >gi|65915|pir||DEFKHG homoserine
dehydrogenase (EC 1.1.1.3) - Corynebacterium glutamicum
>gi|40503|emb|CAA68614.1| (Y00546) homoserine
dehydrogenase (HdH) (AA 1-445) [Corynebacterium
glutamicum] >gi|297383|emb|CAA68536.1| (Y00476)
homoserine dehydrogenase [Corynebacterium glutamicum]
Length = 445
Score = 116 bits (287), Expect = 4e-25
Identities = 107/334 (32%), Positives = 161/334 (48%), Gaps = 40/334 (11%)
Query: 3 VKVSVFGFGTVGRALAEIIAEKRKVFGVELNVVSITDRSGTIWGDFDLLEAKEVKESTGK 62
V +++ GFGTVG + ++ E +G EL + I G LE + + S
Sbjct: 19 VGIALLGFGTVGTEVMRLMTE----YGDEL--------AHRIGGP---LEVRGIAVSDIS 63
Query: 63 LSNIGEY-EVYDFSPQELIEEVKPDILVDV-SSWDDAHEMYSYALAEGISVVTSNKPPIA 120
G E+ LIE DI+V+V + E+ AL G SVVT+NK +A
Sbjct: 64 KPREGVAPELLTEDAFALIEREDVDIVVEVIGGIEYPREVVLAALKAGKSVVTANKALVA 123
Query: 121 NHYDELITLARENGVGIFFESTVMAGTPIIGLLRENLLGEEIVKMEAIVNASTTFILTRM 180
H EL A V ++FE+ V P++G LR +L G++I + IVN +T FIL M
Sbjct: 124 AHSAELADAAEAANVDLYFEAAVAGAIPVVGPLRRSLAGDQIQSVMGIVNGTTNFILDAM 183
Query: 181 EN-GKTFEEAMEEARTLGILEEDPSKDIDGIDAYYKAKILHWVSYGEQPEEEE--REGIR 237
++ G + +++ EA LG E DP+ D++G DA KA IL +++ + ++ EGI
Sbjct: 184 DSTGADYADSLAEATRLGYAEADPTADVEGHDAASKAAILASIAFHTRVTADDVYCEGIS 243
Query: 238 NVKDA---------RNVRLVA-------EISKGRIS--VAPRKLPDNSPLL-VSEVENAA 278
N+ A ++L+A + K IS V P LP + PL V++ NA
Sbjct: 244 NISAADIEAAQQAGHTIKLLAICEKFTNKEGKSAISARVHPTLLPVSHPLASVNKSFNAI 303
Query: 279 LIKTENL-TLTLKGPGGGGKVTASGVFTDIIKAA 311
++ E L G G GG TAS V D++ AA
Sbjct: 304 FVEAEAAGRLMFYGNGAGGAPTASAVLGDVVGAA 337
>dbj|BAB04972.1| (AP001511) homoserine dehydrogenase [Bacillus halodurans]
Length = 417
Score = 114 bits (282), Expect = 2e-24
Identities = 90/327 (27%), Positives = 159/327 (48%), Gaps = 42/327 (12%)
Query: 3 VKVSVFGFGTVGRALAEIIAEKRKVFGVE--LNVVSITDRSGTIWGDFDLLEAKEVKEST 60
+KV V GFGTVG+ + E + + + E L ++ +T+R E E
Sbjct: 2 IKVGVIGFGTVGQGVVESLVQLERGLRKEVTLEMLLVTNR-----------RKHEHSEQY 50
Query: 61 GKLSNIGEYEVYDFSPQELIEEVKPDILVDVSSWDDAHEMYSYALAEGISVVTSNKPPIA 120
+++ ++E + +++ E I + ++ + L +G+ VVT+NK +A
Sbjct: 51 ALVTD--DWETFAARYYDVVFEAAGGI-------EPVYDYVRFFLKKGVPVVTANKKLVA 101
Query: 121 NHYDELITLARENGVGIFFESTVMAGTPIIGLLRENLLGEEIVKMEAIVNASTTFILTRM 180
+EL LA EN + +E+ V G PI+ ++ L + I+N +T +ILT M
Sbjct: 102 ERGEELERLAAENDTYLCYEAAVAGGIPILNAIKGTLATTSFTSVAGILNGTTNYILTGM 161
Query: 181 -ENGKTFEEAMEEARTLGILEEDPSKDIDGIDAYYKAKILHWVSYGEQPEEEE--REGIR 237
E + F++ +EEA+ G E DP+ DI+G DA+YK +IL + +G P ++ R G+
Sbjct: 162 IEQNRPFQDMLEEAQAKGYAEADPTDDIEGYDAWYKIRILARLCFGIWPNRDDISRSGLH 221
Query: 238 NVKD-----ARNVRLVAEISKGRI---------SVAPRKLPDNSPL-LVSEVENAALIKT 282
+V D +++ L ++ GR SVAP ++ P V V NA +++
Sbjct: 222 DVLDWHVELGQSLGLTLKLD-GRASVKNNTIIGSVAPAFFTNDHPFSTVYGVTNAVVLEG 280
Query: 283 ENL-TLTLKGPGGGGKVTASGVFTDII 308
+ + L GPG G + TA+ + D +
Sbjct: 281 KAIERLLFTGPGAGKEATANSMVEDYL 307
>gb|AAF21129.1|L78665_3 (L78665) homoserine dehydrogenase [Methylobacillus flagellatus]
Length = 437
Score = 113 bits (279), Expect = 4e-24
Identities = 97/330 (29%), Positives = 160/330 (48%), Gaps = 42/330 (12%)
Query: 3 VKVSVFGFGTVGRALAEIIAEKRKVF----GVELNVVSITDRSGTIWGDFDLLEAKEVKE 58
+ V + G GTVG ++ ++ G + + + DR+ L A++V
Sbjct: 4 INVGLLGIGTVGGGTYTVLTRNQEEIARRAGRPIAITRVADRN--------LELARKV-- 53
Query: 59 STGKLSNIGEYEVYDFSPQELIEEVKPDILVD-VSSWDDAHEMYSYALAEGISVVTSNKP 117
G+ +V D ++ + DI+V+ + A E+ A+ G VVT+NK
Sbjct: 54 ------TAGQVDVTD-DAFAVVADPSIDIVVELIGGCTVARELVMKAIEHGKHVVTANKG 106
Query: 118 PIANHYDELITLARENGVGIFFESTVMAGTPIIGLLRENLLGEEIVKMEAIVNASTTFIL 177
IA H +E+ A++ GV + FE+ V G PII +RE L I + I+N +T FIL
Sbjct: 107 LIALHGNEIFAAAQQKGVIVAFEAAVAGGIPIIKAVREGLAANRIEWIAGIINGTTNFIL 166
Query: 178 TRM-ENGKTFEEAMEEARTLGILEEDPSKDIDGIDAYYKAKILHWVSYG--EQPEEEERE 234
+ M E F + ++EA+ LG E DP+ D++G+DA +K IL + +G Q ++ E
Sbjct: 167 SEMREKALAFADVLKEAQRLGYAEADPTFDVEGVDAAHKLMILAAIGFGIPMQFDKAYVE 226
Query: 235 GIRNVKDARNVRLVAEI-------------SKG-RISVAPRKLPDNSPLL-VSEVENAAL 279
GI + D+ ++R E+ S+G + V P +P+ + V+ NA L
Sbjct: 227 GISKL-DSIDIRYAEELGYRVKLLGITKRTSQGVELRVHPTLIPEKRLIANVNGAMNAVL 285
Query: 280 IKTENLTLTL-KGPGGGGKVTASGVFTDII 308
+K + + TL G G G + TAS V DI+
Sbjct: 286 VKGDAVGPTLYYGAGAGAEPTASAVVADIV 315
>sp|Q9ZL20|DHOM_HELPJ HOMOSERINE DEHYDROGENASE (HDH) >gi|7431118|pir||C71893 homoserine
dehydrogenase - Helicobacter pylori (strain J99)
>gi|4155323|gb|AAD06338.1| (AE001506) HOMOSERINE
DEHYDROGENASE [Helicobacter pylori J99]
Length = 421
Score = 111 bits (275), Expect = 1e-23
Identities = 97/335 (28%), Positives = 171/335 (50%), Gaps = 45/335 (13%)
Query: 2 KVKVSVFGFGTVGRALAEIIAEKRKVFGVELNVVSITDRSGTIWGDFDLLEAKEVKESTG 61
++ + + G G VG +A+I+ E +++ I DR+G E+K
Sbjct: 4 RLNIGLVGLGCVGSTVAKILQENQEI---------IKDRAGV-----------EIKIKKA 43
Query: 62 KLSNIGEYEVYDFSPQE----LIEEVKPDILVDVSSWDDA-HEMYSYALAEGISVVTSNK 116
+ ++ +++ Y F + +IE+ DI+V++ +A + + LA+ + VT+NK
Sbjct: 44 VVRDVKKHKGYAFEISDDLESVIEDKGIDIVVELMGGVEAPYLLAKKTLAKQKAFVTANK 103
Query: 117 PPIANHYDELITLARENGVGIFFESTVMAGTPIIGLLRENLLGEEIVKMEAIVNASTTFI 176
+A H EL +A+ +G FE++V G PII L++ L I+ + I+N ++ +I
Sbjct: 104 AMLAYHRYELEQIAKNTPIG--FEASVCGGIPIIKALKDGLSANHILSFKGILNGTSNYI 161
Query: 177 LTRM-ENGKTFEEAMEEARTLGILEEDPSKDIDGIDAYYKAKILHWVSYGEQPEEEE--R 233
L++M +N +F++A+++A+ LG E +P DI GIDA +K IL ++YG + EE
Sbjct: 162 LSQMFKNQASFKDALKDAQHLGYAELNPEFDIKGIDAAHKLLILASLAYGIDAKLEEILI 221
Query: 234 EGIRNVKD---------ARNVRLVAEISKGRISVAPRKLPD---NSPLL--VSEVENAAL 279
EGI ++ +++L+ K + + R P N +L V V NA
Sbjct: 222 EGIEKIEPDDMEFAKEFGYSIKLLGIAKKHQDCIELRVHPSMIKNECMLSKVDGVMNAIS 281
Query: 280 IKTENLTLTL-KGPGGGGKVTASGVFTDIIKAALK 313
+ + + TL G G GG+ TAS V +DII+ A K
Sbjct: 282 VIGDKVGETLYYGAGAGGEPTASAVISDIIEIARK 316
>sp|P52986|DHOM_SYNY3 HOMOSERINE DEHYDROGENASE (HDH) >gi|7431117|pir||S74407 homoserine
dehydrogenase (EC 1.1.1.3) - Synechocystis sp. (strain
PCC 6803) >gi|1001182|dbj|BAA10325.1| (D64001)
homoserine dehydrogenase [Synechocystis sp.]
Length = 433
Score = 111 bits (274), Expect = 1e-23
Identities = 99/338 (29%), Positives = 160/338 (47%), Gaps = 52/338 (15%)
Query: 1 MKVKVSVFGFGTVGRALAEIIAEKRKVFGVELNVVSITDRSGTIWGDFDLLEAKEVKEST 60
M VK+ + G GTVG EI+ + + G LL+A EVK +
Sbjct: 1 MTVKIGLLGLGTVGSGTVEILQDPQ--------------------GRSPLLKAIEVK-AV 39
Query: 61 GKLSNIGEYEVYDFSPQELIEEVK-----PDILVDVS---SWDDAHEMYSYALAEGISVV 112
G + ++ + + P+ L +++ PDI + V + A + A+A +V
Sbjct: 40 G-VRSLDKPRQVNLPPEVLTTDLEAIVTDPDIAIVVELMGGLEPARSLILQAIAHKKHIV 98
Query: 113 TSNKPPIANHYDELITLARENGVGIFFESTVMAGTPIIGLLRENLLGEEIVKMEAIVNAS 172
T+NK IA + E+ A ++GV + E+ V G PII L+++L G I + I+N +
Sbjct: 99 TANKAVIARYGPEIYEAANQHGVYVLLEAAVGGGIPIIKPLKQSLGGNRIQSIVGILNGT 158
Query: 173 TTFILTRM-ENGKTFEEAMEEARTLGILEEDPSKDIDGIDAYYKAKILHWVSYGEQPEEE 231
T +IL+RM G F+E + A+ LG E DPS D+DG+DA K IL + +G + + E
Sbjct: 159 TNYILSRMTSEGADFDEVLTAAQQLGYAEADPSADVDGLDAADKIAILASLGFGGRVKRE 218
Query: 232 E--REGIRNVKDAR-----------NVRLVAEISKG------RISVAPRKLPDNSPLL-V 271
+ EGIR+V + +A+ + G ++ V P + + PL V
Sbjct: 219 DVACEGIRSVSAVDIAYADRLGFVIKLLAIADGNAGEDSEALQLRVHPTLIAKDHPLASV 278
Query: 272 SEVENAALIKTENL-TLTLKGPGGGGKVTASGVFTDII 308
+ V N L+ + L + G G G TAS V +D+I
Sbjct: 279 NGVYNGVLVTGDPLGQVMFYGRGAGAGPTASAVVSDVI 316
>sp|P56429|DHOM_HELPY HOMOSERINE DEHYDROGENASE (HDH) >gi|7431119|pir||F64622 homoserine
dehydrogenase (EC 1.1.1.3) - Helicobacter pylori
(strain 26695) >gi|2313952|gb|AAD07869.1| (AE000593)
homoserine dehydrogenase (metL) [Helicobacter pylori
26695]
Length = 421
Score = 111 bits (274), Expect = 1e-23
Identities = 99/331 (29%), Positives = 168/331 (49%), Gaps = 37/331 (11%)
Query: 2 KVKVSVFGFGTVGRALAEIIAEKRKVFGVELNVVSITDRSGTIWGDFDLLEAKEVKESTG 61
++ + + G G VG A+A+I+ E +++ I DR+G G ++VK+ G
Sbjct: 4 RLNIGLVGLGCVGSAVAKILQENQEI---------IKDRAGVGIG-IKKAVVRDVKKHKG 53
Query: 62 KLSNIGEYEVYDFSPQELIEEVKPDILVDVSSWDDA-HEMYSYALAEGISVVTSNKPPIA 120
I + LIE+ + DI+V++ +A + + LA+ + VT+NK +A
Sbjct: 54 YPFEISN------DLESLIEDEEIDIVVELMGGVEAPYLLAKKTLAKQKAFVTANKAMLA 107
Query: 121 NHYDELITLARENGVGIFFESTVMAGTPIIGLLRENLLGEEIVKMEAIVNASTTFILTRM 180
H EL A+ +G FE++V G PII L++ L I+ + I+N ++ +IL++M
Sbjct: 108 YHRYELEQTAKNTPIG--FEASVCGGIPIIKALKDGLSANHILSFKGILNGTSNYILSQM 165
Query: 181 -ENGKTFEEAMEEARTLGILEEDPSKDIDGIDAYYKAKILHWVSYGEQPEEEE--REGIR 237
+N +F++A+++A+ LG E +P DI GIDA +K IL ++YG + EE EGI
Sbjct: 166 FKNQASFKDALKDAQHLGYAELNPEFDIKGIDAAHKLLILASLAYGIDAKLEEILIEGIE 225
Query: 238 NVKD---------ARNVRLVAEISKG----RISVAPRKLPDNSPL-LVSEVENAALIKTE 283
++ +++L+ K + V P + + L V V NA + +
Sbjct: 226 KIEPDDMEFAKEFGYSIKLLGIAKKHPDCIELRVHPSMIKNECMLSKVDGVMNAISVIGD 285
Query: 284 NLTLTL-KGPGGGGKVTASGVFTDIIKAALK 313
+ TL G G GG+ TAS V +DII+ A K
Sbjct: 286 KVGETLYYGAGAGGEPTASAVISDIIEIARK 316
>gb|AAG20683.1| (AE005137) homoserine dehydrogenase; Hom [Halobacterium sp. NRC-1]
Length = 317
Score = 109 bits (271), Expect = 3e-23
Identities = 87/320 (27%), Positives = 144/320 (44%), Gaps = 25/320 (7%)
Query: 3 VKVSVFGFGTVGRALAEIIAEKRKVFGVELNVVSITDRSGTIWGDFDLLEAKEVKESTGK 62
++++V G G VG+A+ + A VV++ D + + + A
Sbjct: 1 MRLAVMGAGAVGQAVVDQAASHGHT------VVAVADSTSAVVDGSGVDAAAVCARKRDA 54
Query: 63 LSNIGEYEVYDF--SPQELIEEVKPDILVDVSSWDDAHEMYSYALAEGISVVTSNKPPIA 120
S IG D + +++ E P L D + AL+ VV +NK P+A
Sbjct: 55 ASEIGTGAPSDALAADYDVLVEATPTTLGDA---EPGFGHVERALSADRHVVLANKGPVA 111
Query: 121 NHYDELITLARENGVGIFFESTVMAGTPIIGLLRENLLGEEIVKMEAIVNASTTFILTRM 180
Y + LA + + FE+TV P++ + E + + + + ++N + F+L+RM
Sbjct: 112 ERYAGVCELAAASAGSLRFEATVGGAIPVLATI-ERIGADRVRAVRGVLNGTANFVLSRM 170
Query: 181 EN-GKTFEEAMEEARTLGILEEDPSKDIDGIDAYYKAKILHWVSYGEQPEEE--EREGIR 237
G +E + EA+ +G+ E DP+ D+DG DA K IL V + + + +GI
Sbjct: 171 AAAGLEYEHVLAEAQEVGVAEADPTFDVDGTDAALKCAILANVIGDREYDLDGVSVDGIT 230
Query: 238 NV---------KDARNVRLVAEISKGRISVAPRKLPDNSPLLVSEVENAALIKTENL-TL 287
V D + +RL+ E+ + V PR +P N L VS N ++TE+ L
Sbjct: 231 GVAPSALELAETDGQTIRLIGEVGPDHVRVGPRLVPANGTLAVSGTTNIVQLETEHAGRL 290
Query: 288 TLKGPGGGGKVTASGVFTDI 307
L G G GG TAS V D+
Sbjct: 291 NLSGQGAGGAATASAVLADV 310
>pir||E81106 probable homoserine dehydrogenase (EC 1.1.1.3) NMA1395 [imported] -
Neisseria meningitidis (group B strain MD58, group A
strain Z2491) >gi|7226467|gb|AAF41609.1| (AE002471)
homoserine dehydrogenase [Neisseria meningitidis MC58]
>gi|7380055|emb|CAB84636.1| (AL162755) putative
homoserine dehydrogenase [Neisseria meningitidis Z2491]
Length = 435
Score = 109 bits (271), Expect = 3e-23
Identities = 95/333 (28%), Positives = 156/333 (46%), Gaps = 43/333 (12%)
Query: 3 VKVSVFGFGTVGRALAEIIAEKRKVF----GVELNVVSITDRSGTIWGDFDLLEAKEVKE 58
V + + G GTVG A ++ + + G E+ + ++ D S +A++
Sbjct: 4 VNIGLLGLGTVGGGTAAVLRDNAEEISRRLGREIRISAVCDLSEE--------KARQTCP 55
Query: 59 STGKLSNIGEYEVYDFSPQELIEEVKPDILVDVSSWDD-AHEMYSYALAEGISVVTSNKP 117
S + + P EL+ D++V++ A + A+ G +VT+NK
Sbjct: 56 SAAFVKD----------PFELVAREDVDVVVELFGGTGIAKDAVLKAIENGKHIVTANKK 105
Query: 118 PIANHYDELITLARENGVGIFFESTVMAGTPIIGLLRENLLGEEIVKMEAIVNASTTFIL 177
+A + +E+ LA + V + FE+ V G PII LRE L I + I+N ++ FIL
Sbjct: 106 LLAEYGNEIFPLAEKQNVIVQFEAAVAGGIPIIKALREGLAANRIKSIAGIINGTSNFIL 165
Query: 178 TRM-ENGKTFEEAMEEARTLGILEEDPSKDIDGIDAYYKAKILHWVSYGEQPEEEE--RE 234
+ M E G F + ++EA+ LG E DP+ DI+G DA +K I+ +++G E
Sbjct: 166 SEMREKGSAFADVLKEAQALGYAEADPTFDIEGNDAGHKITIMSALAFGTPMNFSACYLE 225
Query: 235 GIRNVKDARNVRLVAEI-------------SKG-RISVAPRKLPDNSPLL-VSEVENAAL 279
GI + D+R+++ E+ KG + V P +P++ L V+ V NA
Sbjct: 226 GISKL-DSRDIKYAEELGYRIKLLGITRKTGKGIELRVHPTLIPESRLLANVNGVMNAVR 284
Query: 280 IKTENLTLTL-KGPGGGGKVTASGVFTDIIKAA 311
+ + + TL G G G TAS V DII A
Sbjct: 285 VNADMVGETLYYGAGAGALPTASAVVADIIDIA 317
>sp|P46806|DHOM_MYCLE HOMOSERINE DEHYDROGENASE (HDH) >gi|7431123|pir||T09992 aspartate
kinase (EC 2.7.2.4) / homoserine dehydrogenase (EC
1.1.1.3) - Mycobacterium leprae
>gi|699340|gb|AAA63101.1| (U15186) homoserine
dehydrogenase [Mycobacterium leprae]
Length = 441
Score = 109 bits (269), Expect = 5e-23
Identities = 84/259 (32%), Positives = 132/259 (50%), Gaps = 24/259 (9%)
Query: 77 QELIEEVKPDILVDVSSWDD-AHEMYSYALAEGISVVTSNKPPIANHYDELITLARENGV 135
+EL+ DI+V+V + + + AL G SVVT+NK +A EL A V
Sbjct: 67 EELVSRADVDIVVEVMGPVELSRKAILSALEHGKSVVTANKALLAASTGELAQAAESAHV 126
Query: 136 GIFFESTVMAGTPIIGLLRENLLGEEIVKMEAIVNASTTFILTRMEN-GKTFEEAMEEAR 194
++FE+ V P+I L ++L G+ ++++ IVN +T +IL+ M++ G ++ A+ AR
Sbjct: 127 DLYFEAAVAGAIPVIRPLTQSLAGDTVLRVAGIVNGTTNYILSAMDSTGADYDSALAGAR 186
Query: 195 TLGILEEDPSKDIDGIDAYYKAKILHWVSYGEQPEEEE--REGIRNVKDARNV------- 245
LG E DP+ D++G DA KA IL +++ + ++ REGI + A V
Sbjct: 187 ALGYAEADPTADVEGHDAAAKAAILASIAFHTRVTADDVYREGITKITPADFVSARALGC 246
Query: 246 ---------RLVAEISKGRIS--VAPRKLPDNSPL-LVSEVENAALIKTENL-TLTLKGP 292
R+ A + R+S V P +P + PL VS NA +++ E L G
Sbjct: 247 TIKLLFICERITAADGQQRVSARVYPALVPMSHPLATVSGAFNAVVVEAEAAGRLMFYGQ 306
Query: 293 GGGGKVTASGVFTDIIKAA 311
G GG TAS V D++ AA
Sbjct: 307 GAGGAPTASAVTGDLVMAA 325
>gb|AAD32592.1|AF126720_3 (AF126720) homoserine dehydrogenase [Mycobacterium smegmatis]
Length = 373
Score = 108 bits (268), Expect = 7e-23
Identities = 98/335 (29%), Positives = 158/335 (46%), Gaps = 43/335 (12%)
Query: 3 VKVSVFGFGTVGRALAEIIAEKRKVFGVELNVVSITDRSGTIWGDFDL--LEAKEVKEST 60
+ V+V G G VG + IIA+ S D + I +L + + V +
Sbjct: 6 IGVAVLGLGNVGSEVVRIIAD------------SADDLAARIGAPLELRGVGVRRVADDR 53
Query: 61 GKLSNIGEYEVYDFSPQELIEEVKPDILVDVSS-WDDAHEMYSYALAEGISVVTSNKPPI 119
G + + ++ L+ DI+V+V + A + AL +G SVVT+NK +
Sbjct: 54 GVPTELLTDDI-----DALVSRDDVDIVVEVMGPVEPARKAILSALEQGKSVVTANKALM 108
Query: 120 ANHYDELITLARENGVGIFFESTVMAGTPIIGLLRENLLGEEIVKMEAIVNASTTFILTR 179
A EL A + V ++FE+ V P+I L ++L G+ + ++ IVN +T +IL+
Sbjct: 109 AMSTGELAQAAEKAHVDLYFEAAVAGAIPVIRPLTQSLAGDTVRRVAGIVNGTTNYILSE 168
Query: 180 MEN-GKTFEEAMEEARTLGILEEDPSKDIDGIDAYYKAKILHWVSYGEQPEEEE--REGI 236
M++ G + A+ +A LG E DP+ D++G DA KA IL +++ + ++ REGI
Sbjct: 169 MDSTGADYTSALADASALGYAEADPTADVEGYDAAAKAAILASIAFHTRVTADDVYREGI 228
Query: 237 RNVK-----DARNV-----------RLVAEISKGRIS--VAPRKLPDNSPL-LVSEVENA 277
V AR + RL ++ K R+S V P +P PL V+ NA
Sbjct: 229 TTVSAEDFASARALGCTIKLLAICERLTSDEGKDRVSARVYPALVPLTHPLAAVNGAFNA 288
Query: 278 ALIKTENL-TLTLKGPGGGGKVTASGVFTDIIKAA 311
+++ E L G G GG TA V D++ AA
Sbjct: 289 VVVEAEAAGRLMFYGQGAGGAPTAFAVMGDVVMAA 323
>pir||A72716 probable homoserine dehydrogenase APE1144 - Aeropyrum pernix
(strain K1) >gi|5104814|dbj|BAA80129.1| (AP000060) 334aa
long hypothetical homoserine dehydrogenase [Aeropyrum
pernix]
Length = 334
Score = 106 bits (262), Expect = 4e-22
Identities = 100/329 (30%), Positives = 153/329 (46%), Gaps = 32/329 (9%)
Query: 1 MKVKVSVFGFGTVGRALAEIIAEKRKVFGVELNVVSITDRSGTIWGDFDLLEAKEVKEST 60
M V+V+V GFG VGR LA ++ E+ G+ L +I R + FD E S
Sbjct: 1 MAVRVAVAGFGGVGRRLARLLLERGGSHGLSL-AAAIDSRGHAV---FDSRGCVEEALSA 56
Query: 61 GKLSNIGEYEVYDFSPQELIEEVKPD--ILVDVSSWDDAHEMYSY---ALAEGISVVTSN 115
+ G S ++ + D +L SS Y AL +G VV ++
Sbjct: 57 PRGGLAGVSCGAPGSGPGVLRGLGYDALVLTTASSPGTGEPGLGYARAALEDGKVVVAAD 116
Query: 116 KPPIANHYDELITLARENG---VGIFFESTVMAGTPIIGLLRENLLGEEIVKMEAIVNAS 172
KPP+A L E+G G+F+++TVMAGTP+I LLR L G ++++ ++N +
Sbjct: 117 KPPVA-------LLLLEHGGPPPGLFYKATVMAGTPLIDLLRVGLAGRRVLRVVGVLNGT 169
Query: 173 TTFILTRMENGKTFEEAMEEARTLGILEEDPSKDIDGIDAYYKAKILHW-----VSYGE- 226
+ +IL + G EEA+E A LGI E DPS D+ G+D KA I+ V G+
Sbjct: 170 SNYILNLLMEGVPLEEAVEAAVRLGIAEPDPSADLRGVDLALKASIVAQTLGCPVGPGDV 229
Query: 227 ------QPEEEEREGIRNVKDARNVRLVAEISKGRISVAPRKLPDNSPLL-VSEVENAAL 279
G+R A +++ R + S L + NAA+
Sbjct: 230 VVGGTVYDAAGWAPGLRGAGAALRYTARVDVAGCRAEIGLTLHGAGSRLYSLPGSLNAAV 289
Query: 280 IKTENLTLTLKGPGGGGKVTASGVFTDII 308
I E+ T+ L+GPG G VTA+ + +D++
Sbjct: 290 IGLEDSTIYLEGPGAGLGVTAATLLSDLV 318
>emb|CAC12304.1| (AL445066) homoserine dehydrogenase related protein [Thermoplasma
acidophilum]
Length = 324
Score = 106 bits (262), Expect = 4e-22
Identities = 76/259 (29%), Positives = 137/259 (52%), Gaps = 16/259 (6%)
Query: 2 KVKVSVFGFGTVGRALAEII-AEKRKVFGVELNVVSITD-RSGTIWGDFDLLEAKEVKES 59
++++ + G G VG + II A R+ + VV ++D RS + D+ KE
Sbjct: 3 EIRIILMGTGNVGLNVLRIIDASNRRRSAFSIKVVGVSDSRSYASGRNLDISSIISNKEK 62
Query: 60 TGKLSNIGEYEVYDFS-PQELIEEVKPDILVDVS--SWDDAHE--MYSYALAEGISVVTS 114
TG++S+ FS P++L+ E D+LVD + S D E +Y A G++VVT+
Sbjct: 63 TGRISDRA------FSGPEDLMGEAA-DLLVDCTPASRDGVREYSLYRMAFESGMNVVTA 115
Query: 115 NKPPIANHYDELITLARENGVGIFFESTVMAGTPIIGLLRENLLGEEIVKMEAIVNASTT 174
NK +AN + +++ A +N I +E+TV G P+ +L ++L ++ + IV+++
Sbjct: 116 NKSGLANKWHDIMDSANQNSKYIRYEATVAGGVPLFSVLDYSILPSKVKRFRGIVSSTIN 175
Query: 175 FILTRMENGKTFEEAMEEARTLGILEEDPSKDIDGIDAYYKAKILHWVSYGEQ--PEEEE 232
+++ M NG++ + +++A GI E +P D++G+DA K+ IL +G + + E
Sbjct: 176 YVIRNMANGRSLRDVVDDAIKKGIAESNPQDDLNGLDAARKSVILVNHIFGTEYTLNDVE 235
Query: 233 REGIRNVKDARNVRLVAEI 251
G+ N RLV E+
Sbjct: 236 YSGVDERSYNANDRLVTEV 254
>pir||T06246 aspartate kinase (EC 2.7.2.4) / homoserine dehydrogenase (EC
1.1.1.3) precursor - soybean (fragment)
>gi|2970556|gb|AAC05983.1| (AF049708)
aspartokinase-homoserine dehydrogenase [Glycine max]
Length = 909
Score = 105 bits (260), Expect = 6e-22
Identities = 92/357 (25%), Positives = 166/357 (45%), Gaps = 53/357 (14%)
Query: 3 VKVSVFGFGTVGRALAEIIAEK----RKVFGVELNVVSITDRSGTIWGD--FDLLEAKEV 56
+ + + G G +G L + + ++ ++ F ++L V+ I + D DL +E+
Sbjct: 558 IAMGIIGPGLIGSTLLDQLRDQASTLKEEFNIDLRVMGILGSKSMLLSDVGIDLARWREL 617
Query: 57 KESTGKLSNIGEYEVYDFSPQELIEEVKPDILVDVSSWDDAHEMYSYA-LAEGISVVTSN 115
+E G+++N+ ++ V I LVD ++ D A Y Y L +GI VVT N
Sbjct: 618 REERGEVANVEKF-VQHVHGNHFIPNTA---LVDCTA-DSAIAGYYYDWLRKGIHVVTPN 672
Query: 116 KPPIANHYDELI---TLARENGVGIFFESTVMAGTPIIGLLRENL-LGEEIVKMEAIVNA 171
K + D+ + L R++ F+E+TV AG PI+ LR L G++I+++E I +
Sbjct: 673 KKANSGPLDQYLKLRALQRQSYTHYFYEATVGAGLPIVSTLRGLLETGDKILQIEGIFSG 732
Query: 172 STTFILTRMENGKTFEEAMEEARTLGILEEDPSKDIDGIDAYYKAKILHWVS-------- 223
+ ++I ++G+ F E + EA+ G E DP D+ G D K IL S
Sbjct: 733 TLSYIFNNFKDGRAFSEVVSEAKEAGYTEPDPRDDLSGTDVARKVIILARESGLKLELSN 792
Query: 224 -------------------YGEQPEEEEREGIRNVKDARNVRL------VAEISKGRISV 258
+ ++P + ++E + +DA N V +++ + V
Sbjct: 793 IPVESLVPEPLRACASAQEFMQEPPKFDQEFTKKQEDAENAGEVLRYVGVVDVTNEKGVV 852
Query: 259 APRKLPDNSPLL-VSEVENAALIKT---ENLTLTLKGPGGGGKVTASGVFTDIIKAA 311
R+ + P +S +N T ++ L ++GPG G +VTA G+F+DI++ A
Sbjct: 853 ELRRYKKDHPFAQLSGSDNIIAFTTRRYKDQPLIVRGPGAGAQVTAGGIFSDILRLA 909
>sp|Q10601|DHOM_MYCTU HOMOSERINE DEHYDROGENASE (HDH) >gi|7431115|pir||B70773 probable
thrA protein - Mycobacterium tuberculosis (strain H37RV)
>gi|1322418|emb|CAA97759.1| (Z73419) thrA [Mycobacterium
tuberculosis]
Length = 441
Score = 104 bits (257), Expect = 1e-21
Identities = 94/333 (28%), Positives = 149/333 (44%), Gaps = 39/333 (11%)
Query: 3 VKVSVFGFGTVGRALAEIIAEKRKVFGVELNVVSITDRSGTIWGDFDLLEAKEVKESTGK 62
V V+V G G VG + II + + + G + V G
Sbjct: 8 VGVAVLGLGNVGSEVVRIIENSAEDLAARVGAPLVLRGIGV----------RRVTTDRGV 57
Query: 63 LSNIGEYEVYDFSPQELIEEVKPDILVDVSS-WDDAHEMYSYALAEGISVVTSNKPPIAN 121
E+ +EL+ DI+V+V + + + AL G SVVT+NK +A
Sbjct: 58 -----PIELLTDDIEELVAREDVDIVVEVMGPVEPSRKAILGALERGKSVVTANKALLAT 112
Query: 122 HYDELITLARENGVGIFFESTVMAGTPIIGLLRENLLGEEIVKMEAIVNASTTFILTRME 181
EL A V ++FE+ V P+I L ++L G+ ++++ IVN +T +IL+ M+
Sbjct: 113 STGELAQAAESAHVDLYFEAAVAGAIPVIRPLTQSLAGDTVLRVAGIVNGTTNYILSAMD 172
Query: 182 N-GKTFEEAMEEARTLGILEEDPSKDIDGIDAYYKAKILHWVSYGEQPEEEE--REGIRN 238
+ G + A+ +A LG E DP+ D++G DA KA IL +++ + ++ REGI
Sbjct: 173 STGADYASALADASALGYAEADPTADVEGYDAAAKAAILASIAFHTRVTADDVYREGITK 232
Query: 239 VKDAR----------------NVRLVAEISKGRIS--VAPRKLPDNSPL-LVSEVENAAL 279
V A R+ + R+S V P +P + PL V+ NA +
Sbjct: 233 VTPADFGSAHALGCTIKLLSICERITTDEGSQRVSARVYPALVPLSHPLAAVNGAFNAVV 292
Query: 280 IKTENL-TLTLKGPGGGGKVTASGVFTDIIKAA 311
++ E L G G GG TAS V D++ AA
Sbjct: 293 VEAEAAGRLMFYGQGAGGAPTASAVTGDLVMAA 325
>pir||T06242 aspartate kinase (EC 2.7.2.4) / homoserine dehydrogenase (EC
1.1.1.3) precursor - soybean chloroplast
>gi|2970447|gb|AAC05981.1| (AF049706)
aspartokinase-homoserine dehydrogenase [Glycine max]
Length = 916
Score = 102 bits (252), Expect = 5e-21
Identities = 90/366 (24%), Positives = 166/366 (44%), Gaps = 59/366 (16%)
Query: 3 VKVSVFGFGTVGRALAEIIAEK----RKVFGVELNVVSITDRSGTIWGD--FDLLEAKEV 56
+ + + G G +G L E + ++ ++ F ++L V+ I + D DL +E+
Sbjct: 558 IAMGIIGPGLIGSTLLEQLRDQASTLKEEFNIDLRVMGILGSKSMLLSDVGIDLARWREL 617
Query: 57 KESTGKLSNIGEYEVY----DFSPQELIEEVKPDILVDVSSWDDAHEMYSYALAEGISVV 112
+E G+++N+ ++ + F P + + D ++ A Y + L +GI VV
Sbjct: 618 REERGEVANMEKFVQHVHGNHFIPNTALVDCTADSVI-------AGYYYDW-LRKGIHVV 669
Query: 113 TSNKPPIANHYDELI---TLARENGVGIFFESTVMAGTPIIGLLRENL-LGEEIVKMEAI 168
T NK + D+ + L R++ F+E+TV AG PI+ LR L G++I+++E I
Sbjct: 670 TPNKKANSGPLDQYLKLRALQRQSYTHYFYEATVGAGLPIVSTLRGLLETGDKILQIEGI 729
Query: 169 VNASTTFILTRMENGKTFEEAMEEARTLGILEEDPSKDIDGIDAYYKAKILHWVS----- 223
+ + ++I ++G+ F E + EA+ G E DP D+ G D K IL S
Sbjct: 730 FSGTLSYIFNNFKDGRAFSEVVSEAKEAGYTEPDPRDDLSGTDVARKVIILARESGLKLE 789
Query: 224 ----------------------YGEQPEEEEREGIRNVKDARN-------VRLVAEISKG 254
+ ++ + ++E + +DA N V +V +K
Sbjct: 790 LSNIPVESPVPEPLRACASAQEFMQELPKFDQEFTKKQEDAENAGEVLRYVGVVDVTNKK 849
Query: 255 RISVAPRKLPDNSPLLVSEVENAALIKT---ENLTLTLKGPGGGGKVTASGVFTDIIKAA 311
+ R D+ +S +N T ++ L ++GPG G +VTA G+F+DI++ A
Sbjct: 850 GVVELRRYKKDHPFAQLSGSDNIIAFTTRRYKDQPLIVRGPGAGAQVTAGGIFSDILRLA 909
Query: 312 LKFPSP 317
+P
Sbjct: 910 SYLGAP 915
>pir||E81432 homoserine dehydrogenase (EC 1.1.1.3) Cj0149c [imported] -
Campylobacter jejuni (strain NCTC 11168)
>gi|6967643|emb|CAB72633.1| (AL139074) homoserine
dehydrogenase [Campylobacter jejuni]
Length = 415
Score = 101 bits (249), Expect = 1e-20
Identities = 93/328 (28%), Positives = 162/328 (49%), Gaps = 40/328 (12%)
Query: 3 VKVSVFGFGTVGRALAEIIAEKRKVFGVELNVVSITDRSGTIWGDFDLLEAKEVKESTGK 62
+KV++ G+GTVG A+ + + E K+ I R G L K +
Sbjct: 1 MKVAILGYGTVGSAVVKFLLENDKL---------IRARCGQSITPVIALARSPKKNALIP 51
Query: 63 LSNIGEYEVYDFSPQELIEEVKPDILVDVSSW-DDAHEMYSYALAEGISVVTSNKPPIAN 121
+++ S E++ D+ V++ D+A ++ S L + +VVT+NK +A
Sbjct: 52 ITH---------SVAEILN-ADVDVFVELMGGVDEAFKIVSEILKKKKAVVTANKAMLAY 101
Query: 122 HYDELITLARENGVGIFFESTVMAGTPIIGLLRENLLGEEIVKMEAIVNASTTFILTRM- 180
H EL LA+ G +E++V G PII +L+E L I+ ++ I+N ++ +IL+ M
Sbjct: 102 HRYELENLAKNLAFG--YEASVAGGIPIIKVLKEGLSANNILAIKGILNGTSNYILSSMS 159
Query: 181 ENGKTFEEAMEEARTLGILEEDPSKDIDGIDAYYKAKILHWVSYG--EQPEEEEREGIRN 238
+ +F++A++ A+ LG E DP+ DI+G DA +K +L ++Y +PE+ EGI
Sbjct: 160 QKNMSFKQALQIAQNLGYAEADPTFDIEGQDAAHKLLVLSSIAYNLKAKPEDILIEGISE 219
Query: 239 VKDAR---------NVRL--VAEISKGRIS--VAPRKLPDNSPLL-VSEVENAALIKTEN 284
+ ++L +A++ + ++ V P + L V V NA I +
Sbjct: 220 IAPEDMYFANEFEFTIKLLGIAKVRENKVELRVHPTMIDKEKMLAKVDGVMNAISINGDL 279
Query: 285 LTLTL-KGPGGGGKVTASGVFTDIIKAA 311
L +L G G GG+ TAS V +D++ A
Sbjct: 280 LGESLYYGAGAGGEATASAVISDLMDIA 307
>pir||S46497 aspartate kinase (EC 2.7.2.4) / homoserine dehydrogenase (EC
1.1.1.3) precursor - Arabidopsis thaliana
Length = 911
Score = 100 bits (247), Expect = 2e-20
Identities = 91/364 (25%), Positives = 155/364 (42%), Gaps = 59/364 (16%)
Query: 5 VSVFGFGTVGRALAEIIAEKRKV----FGVELNVVSITDRSGTIWGD--FDLLEAKEVKE 58
V + G G +G L + I ++ V F ++L V+ IT S + + DL +E+ +
Sbjct: 555 VGIIGPGLIGGTLLDQIRDQAAVLKEEFKIDLRVIGITGSSKMLMSESGIDLSRWRELMK 614
Query: 59 STGKLSNIGEYEVY----DFSPQELIEEVKPDILVDVSSWDDAHEMYSYALAEGISVVTS 114
G+ +++ ++ Y F P ++VD ++ D Y L GI VVT
Sbjct: 615 EEGEKADMEKFTQYVKGNHFIPNS--------VMVDCTADADIASCYYDWLLRGIHVVTP 666
Query: 115 NKPPIANHYDELIT---LARENGVGIFFESTVMAGTPIIGLLRENL-LGEEIVKMEAIVN 170
NK + D+ + L R++ F+E+TV AG PII LR L G++I+++E I +
Sbjct: 667 NKKANSGPLDQYLKIRDLQRKSYTHYFYEATVGAGLPIISTLRGLLETGDKILRIEGIFS 726
Query: 171 ASTTFILTRMENGKTFEEAMEEARTLGILEEDPSKDIDGIDAYYKAKILHWVS------- 223
+ +++ ++F E + EA+ G E DP D+ G D K IL S
Sbjct: 727 GTLSYLFNNFAGTRSFSEVVAEAKQAGFTEPDPRDDLSGTDVARKVTILARESGLKLDLE 786
Query: 224 ---------------------------YGEQPEEEEREGIRNVKDARNVRLVAEISKGRI 256
+ E+ ++ E + R V +V + K
Sbjct: 787 GLPIQNLVPKPLQACASAEEFMEKLPQFDEELSKQREEAEAAGEVLRYVGVVDAVEKKGT 846
Query: 257 SVAPRKLPDNSPLLVSEVENAALIKTENL---TLTLKGPGGGGKVTASGVFTDIIKAALK 313
R D+ +S +N T+ L ++GPG G +VTA G+F+DI++ A
Sbjct: 847 VELKRYKKDHPFAQLSGADNIIAFTTKRYKEQPLIVRGPGAGAQVTAGGIFSDILRLAFY 906
Query: 314 FPSP 317
+P
Sbjct: 907 LGAP 910
>pir||H82086 aspartokinase I/homoserine dehydrogenase, threonine-sensitive
VC2364 [imported] - Vibrio cholerae (group O1 strain
N16961) >gi|9656933|gb|AAF95507.1| (AE004306)
aspartokinase I/homoserine dehydrogenase,
threonine-sensitive [Vibrio cholerae]
Length = 825
Score = 100 bits (247), Expect = 2e-20
Identities = 94/353 (26%), Positives = 163/353 (45%), Gaps = 57/353 (16%)
Query: 5 VSVFGFGTVGRALAEIIAEKRKVF---GVELNVVSITDRSGTIWGDFDLLEAKEVKESTG 61
V V G G VG L + I ++ G+ + V + + G + L +++
Sbjct: 474 VFVVGVGGVGGELVDQIQRQQAKLAEKGIMMRVCGLANSKGMLLDSQGL----PLEQWRD 529
Query: 62 KLSNIGEYEVYDFSPQELIEEVKPD-----ILVDVSSWDDAHEMYSYALAEGISVVTSNK 116
++ N + FS + L+ V+ + +LVD +S D+ Y+ LA G VVT NK
Sbjct: 530 RMINADQA----FSLENLVALVQRNHIINPVLVDCTSSDEIANQYADFLAAGFHVVTPNK 585
Query: 117 PPIA---NHYDELITLARENGVGIFFESTVMAGTPIIGLLRENLL--GEEIVKMEAIVNA 171
++Y +L +AR + + +E+TV AG P+I L +NL+ G+E+ K I++
Sbjct: 586 KANTASMSYYHQLRNVARHSRRKLMYETTVGAGLPVIENL-QNLIAAGDELEKFSGILSG 644
Query: 172 STTFILTRMENGKTFEEAMEEARTLGILEEDPSKDIDGIDAYYKAKIL------------ 219
S +FI +++ G T +A + A+ G E DP D+ G+D K IL
Sbjct: 645 SLSFIFGKLDEGMTLSQATQLAKEKGFTEPDPRDDLSGMDVARKLLILAREAGYELELSD 704
Query: 220 ------------------HWVSYGEQPEEEEREGIRNVK-DARNVRLVAEISKGRISVAP 260
+++ Q + E + K + + +R VA+I G+ V
Sbjct: 705 VDVEQALPAGFDASGSVEEFMARLAQADAAFAERVAQAKAEGKVLRYVAQIVDGQCQVRI 764
Query: 261 RKLPDNSPLL-VSEVENAALIKT---ENLTLTLKGPGGGGKVTASGVFTDIIK 309
+ +N P+ V E ENA + + + L L+G G G +VTA+GVF+D+++
Sbjct: 765 VAVDENDPMFKVKEGENALAFYSRYYQPIPLVLRGYGAGSEVTAAGVFSDVMR 817
>gb|AAD21689.1| (AC004793) Identical to gb|X71364 gene for aspartate kinase
homoserine dehydrogenase from Arabidopsis thaliana
Length = 911
Score = 100 bits (246), Expect = 3e-20
Identities = 91/364 (25%), Positives = 155/364 (42%), Gaps = 59/364 (16%)
Query: 5 VSVFGFGTVGRALAEIIAEKRKV----FGVELNVVSITDRSGTIWGD--FDLLEAKEVKE 58
V + G G +G L + I ++ V F ++L V+ IT S + + DL +E+ +
Sbjct: 555 VGIIGPGLIGGTLLDQIRDQAAVLKEEFKIDLRVIGITGSSKMLMSESGIDLSRWRELMK 614
Query: 59 STGKLSNIGEYEVY----DFSPQELIEEVKPDILVDVSSWDDAHEMYSYALAEGISVVTS 114
G+ +++ ++ Y F P ++VD ++ D Y L GI VVT
Sbjct: 615 EEGEKADMEKFTQYVKGNHFIPNS--------VMVDCTADADIASCYYDWLLRGIHVVTP 666
Query: 115 NKPPIANHYDELIT---LARENGVGIFFESTVMAGTPIIGLLRENL-LGEEIVKMEAIVN 170
NK + D+ + L R++ F+E+TV AG PII LR L G++I+++E I +
Sbjct: 667 NKKANSGPLDQYLKIRDLQRKSYTHYFYEATVGAGLPIISTLRGLLETGDKILRIEGIFS 726
Query: 171 ASTTFILTRMENGKTFEEAMEEARTLGILEEDPSKDIDGIDAYYKAKILHWVS------- 223
+ +++ ++F E + EA+ G E DP D+ G D K IL S
Sbjct: 727 GTLSYLFNNFVGTRSFSEVVAEAKQAGFTEPDPRDDLSGTDVARKVTILARESGLKLDLE 786
Query: 224 ---------------------------YGEQPEEEEREGIRNVKDARNVRLVAEISKGRI 256
+ E+ ++ E + R V +V + K
Sbjct: 787 GLPVQNLVPKPLQACASAEEFMEKLPQFDEELSKQREEAEAAGEVLRYVGVVDAVEKKGT 846
Query: 257 SVAPRKLPDNSPLLVSEVENAALIKTENL---TLTLKGPGGGGKVTASGVFTDIIKAALK 313
R D+ +S +N T+ L ++GPG G +VTA G+F+DI++ A
Sbjct: 847 VELKRYKKDHPFAQLSGADNIIAFTTKRYKEQPLIVRGPGAGAQVTAGGIFSDILRLAFY 906
Query: 314 FPSP 317
+P
Sbjct: 907 LGAP 910
>sp|P44505|AKH_HAEIN BIFUNCTIONAL ASPARTOKINASE/HOMOSERINE DEHYDROGENASE (AK-HD)
[INCLUDES: ASPARTOKINASE ; HOMOSERINE DEHYDROGENASE ]
>gi|1073872|pir||A64048 aspartate kinase (EC 2.7.2.4) I
/ homoserine dehydrogenase (EC 1.1.1.3) - Haemophilus
influenzae (strain Rd KW20) >gi|1573040|gb|AAC21767.1|
(U32694) aspartokinase I / homoserine dehydrogenase I
(thrA) [Haemophilus influenzae Rd]
Length = 815
Score = 100 bits (246), Expect = 3e-20
Identities = 99/350 (28%), Positives = 162/350 (46%), Gaps = 47/350 (13%)
Query: 3 VKVSVFGFGTVGRALAEIIAEKRKVFG---VELNVVSITDRSGTIWGDFDLLEAKEVKES 59
V + + G G VG L E + +++ VE+ V +I + S + D + L ++ K
Sbjct: 466 VDMFLVGVGGVGGELIEQVKRQKEYLAKKNVEIRVCAIAN-SNRMLLDENGLNLEDWKND 524
Query: 60 TGKLSNIGEYEVYDFSPQELIEEVKPDILVDVSSWDDAHEMYSYALAEGISVVTSNKPPI 119
+ +++V S +L V P + VD +S + +Y+ AL EG VVT NK
Sbjct: 525 LENATQPSDFDVL-LSFIKLHHVVNP-VFVDCTSAESVAGLYARALKEGFHVVTPNKKAN 582
Query: 120 AN---HYDELITLARENGVGIFFESTVMAGTPIIGLLRENLL--GEEIVKMEAIVNASTT 174
+Y+EL A+ + +E+ V AG P+I L +NLL G+E+ E I++ S +
Sbjct: 583 TRELVYYNELRQNAQASQHKFLYETNVGAGLPVIENL-QNLLAAGDELEYFEGILSGSLS 641
Query: 175 FILTRMENGKTFEEAMEEARTLGILEEDPSKDIDGIDAYYKAKIL--------------- 219
FI ++E G + E AR G E DP D+ G D K IL
Sbjct: 642 FIFGKLEEGLSLSEVTALAREKGFTEPDPRDDLSGQDVARKLLILAREAGIELELSDVEV 701
Query: 220 ---------------HWVSYGEQPEEEEREGIRNVK-DARNVRLVAEISKGRISVAPRKL 263
+++ Q +EE + + K + + +R V +IS+G+ V+ +
Sbjct: 702 EGVLPKGFSDGKSADEFMAMLPQLDEEFKTRVATAKAEGKVLRYVGKISEGKCKVSIVAV 761
Query: 264 PDNSPLL-VSEVENAALIKT---ENLTLTLKGPGGGGKVTASGVFTDIIK 309
N+PL V + ENA T + + L L+G G G VTA+G+F DI++
Sbjct: 762 DLNNPLYKVKDGENALAFYTRYYQPIPLLLRGYGAGNAVTAAGIFADILR 811
>sp|P49079|AKH1_MAIZE BIFUNCTIONAL ASPARTOKINASE/HOMOSERINE DEHYDROGENASE 1, CHLOROPLAST
PRECURSOR (AK-HD 1) (AK-HSDH 1) [INCLUDES: ASPARTOKINASE
; HOMOSERINE DEHYDROGENASE ] >gi|7434566|pir||T02953
aspartate kinase (EC 2.7.2.4) / homoserine dehydrogenase
(EC 1.1.1.3) - maize >gi|500851|gb|AAA74360.1| (L33912)
aspartate kinase-homoserine dehydrogenase [Zea mays]
Length = 920
Score = 98.3 bits (241), Expect = 1e-19
Identities = 96/361 (26%), Positives = 161/361 (44%), Gaps = 53/361 (14%)
Query: 5 VSVFGFGTVGRALAEIIAEKRKVF----GVELNVVSITDRSGTIWGDF--DLLEAKEVKE 58
V + G G +GR L + ++ V ++L V+ I + D DL + KE +
Sbjct: 564 VGIIGPGLIGRTLLNQLKDQAAVLKENMNIDLRVMGIAGSRTMLLSDIGVDLTQWKEKLQ 623
Query: 59 STGKLSNIGEYEVYDFSPQELIEEVKPDILVDVSSWDDAHEMYSYALAEGISVVTSNKPP 118
+ + +N+ ++ V+ S +LVD ++ Y L +GI V+T NK
Sbjct: 624 TEAEPANLDKF-VHHLSENHFFPN---RVLVDCTADTSVASHYYDWLKKGIHVITPNKKA 679
Query: 119 IA---NHYDELITLARENGVGIFFESTVMAGTPIIGLLRENL-LGEEIVKMEAIVNASTT 174
+ + Y +L TL R + F+E+TV AG PII LR L G++I+++E I + + +
Sbjct: 680 NSGPLDRYLKLRTLQRASYTHYFYEATVGAGLPIISTLRGLLETGDKILRIEGIFSGTLS 739
Query: 175 FILTRMENGKTFEEAMEEARTLGILEEDPSKDIDGIDAYYKAKILHWVS----------- 223
+I E +TF + + EA+ G E DP D+ G D K IL S
Sbjct: 740 YIFNNFEGARTFSDVVAEAKKAGYTEPDPRDDLSGTDVARKVIILARESGLGLELSDIPV 799
Query: 224 ----------------YGEQPEEEEREGIRNVKDA-------RNVRLVAEIS-KGRISVA 259
Y ++ + + R K+A R V +V +S KG++ +
Sbjct: 800 RSLVPEALKSCTSADEYMQKLPSFDEDWARERKNAEAAGEVLRYVGVVDVVSKKGQVELR 859
Query: 260 PRKLPDNSPLLVSEVENAALIKT---ENLTLTLKGPGGGGKVTASGVFTDIIKAALKFPS 316
K D+ +S +N T ++ L ++GPG G +VTA GVF DI++ + +
Sbjct: 860 AYK-RDHPFAQLSGSDNIIAFTTSRYKDQPLIVRGPGAGAEVTAGGVFCDILRLSSYLGA 918
Query: 317 P 317
P
Sbjct: 919 P 919
>sp|P27725|AK1H_SERMA BIFUNCTIONAL ASPARTOKINASE/HOMOSERINE DEHYDROGENASE I (AKI-HDI)
[INCLUDES: ASPARTOKINASE I ; HOMOSERINE DEHYDROGENASE I
] >gi|421254|pir||B47057 aspartate kinase (EC 2.7.2.4) I
/ homoserine dehydrogenase (EC 1.1.1.3) I - Serratia
marcescens >gi|47273|emb|CAA43212.1| (X60821) aspartate
kinase [Serratia marcescens]
Length = 819
Score = 96.0 bits (235), Expect = 5e-19
Identities = 100/359 (27%), Positives = 160/359 (43%), Gaps = 65/359 (18%)
Query: 3 VKVSVFGFGTVGRALAEIIAEKR----------KVFGVELNVVSITDRSGTIWGDF-DLL 51
++V V G G VG AL E I ++ +V G+ + V +T+ G + D L
Sbjct: 466 IEVFVIGVGGVGGALIEQIYRQQPWLKQKHIDLRVCGIANSRVMLTNVHGIALDSWRDAL 525
Query: 52 EAKEVKESTGKLSN-IGEYEVYDFSPQELIEEVKPDILVDVSSWDDAHEMYSYALAEGIS 110
+ + G+L + EY + + ++VD +S + Y LA+G
Sbjct: 526 AGAQEPFNLGRLIRLVKEYHLLN------------PVIVDCTSSQAVADQYVDFLADGFH 573
Query: 111 VVTSNKPPIA---NHYDELITLARENGVGIFFESTVMAGTPIIGLLRENLL--GEEIVKM 165
VVT NK N+Y +L A + +++ V AG P+I L +NLL G+E+V+
Sbjct: 574 VVTPNKKANTSSMNYYQQLRAAAAGSHRKFLYDTNVGAGLPVIENL-QNLLNAGDELVRF 632
Query: 166 EAIVNASTTFILTRMENGKTFEEAMEEARTLGILEEDPSKDIDGIDAYYKAKIL------ 219
I++ S +FI +++ G + A +AR G E DP D+ G+D K IL
Sbjct: 633 SGILSGSLSFIFGKLDEGLSLSAATLQARANGYTEPDPRDDLSGMDVARKLLILAREAGY 692
Query: 220 ---------------HWVSYGE------QPEEEEREGIRNVKDA----RNVRLVAEISKG 254
+ + G+ + E ++E RNV +A + +R V I +G
Sbjct: 693 KLELSDIEVEPVLPPSFDASGDVDTFLARLPELDKEFARNVANAAEQGKVLRYVGLIDEG 752
Query: 255 RISVAPRKLPDNSPLL-VSEVENAALIKT---ENLTLTLKGPGGGGKVTASGVFTDIIK 309
R V + N PL V ENA + + L L L+G G G VTA+GVF D+++
Sbjct: 753 RCKVRIEAVDGNDPLYKVKNGENALAFYSRYYQPLPLVLRGYGAGNDVTAAGVFADLLR 811
>dbj|BAA38474.1| (D10385) aspartokinase I-homoserine dehydrogenase I [Serratia
marcescens]
Length = 819
Score = 96.0 bits (235), Expect = 5e-19
Identities = 100/359 (27%), Positives = 160/359 (43%), Gaps = 65/359 (18%)
Query: 3 VKVSVFGFGTVGRALAEIIAEKR----------KVFGVELNVVSITDRSGTIWGDF-DLL 51
++V V G G VG AL E I ++ +V G+ + V +T+ G + D L
Sbjct: 466 IEVFVIGVGGVGGALIEQIYRQQPWLKQKHIDLRVCGIANSRVMLTNVHGIALDSWRDAL 525
Query: 52 EAKEVKESTGKLSN-IGEYEVYDFSPQELIEEVKPDILVDVSSWDDAHEMYSYALAEGIS 110
+ + G+L + EY + + ++VD +S + Y LA+G
Sbjct: 526 AGAQEPFNLGRLIRLVKEYHLLN------------PVIVDCTSSQAVADQYVDFLADGFH 573
Query: 111 VVTSNKPPIA---NHYDELITLARENGVGIFFESTVMAGTPIIGLLRENLL--GEEIVKM 165
VVT NK N+Y +L A + +++ V AG P+I L +NLL G+E+V+
Sbjct: 574 VVTPNKKANTSSMNYYQQLRAAAAGSHRKFLYDTNVGAGLPVIENL-QNLLNAGDELVRF 632
Query: 166 EAIVNASTTFILTRMENGKTFEEAMEEARTLGILEEDPSKDIDGIDAYYKAKIL------ 219
I++ S +FI +++ G + A +AR G E DP D+ G+D K IL
Sbjct: 633 SGILSGSLSFIFGKLDEGLSLSAATLQARANGYTEPDPRDDLSGMDVARKLLILAREAGY 692
Query: 220 ---------------HWVSYGE------QPEEEEREGIRNVKDA----RNVRLVAEISKG 254
+ + G+ + E ++E RNV +A + +R V I +G
Sbjct: 693 KLELSDIEVEPVLPPSFDASGDVDTFLARLPELDKEFARNVANAAEQGKVLRYVGLIDEG 752
Query: 255 RISVAPRKLPDNSPLL-VSEVENAALIKT---ENLTLTLKGPGGGGKVTASGVFTDIIK 309
R V + N PL V ENA + + L L L+G G G VTA+GVF D+++
Sbjct: 753 RCKVRIEAVDGNDPLYKVKNGENALAFYSRYYQPLPLVLRGYGAGNDVTAAGVFADLLR 811
>dbj|BAA38480.1| (D10387) aspartokinase I-homoserine dehydrogenase I [Serratia
marcescens]
Length = 819
Score = 96.0 bits (235), Expect = 5e-19
Identities = 100/359 (27%), Positives = 160/359 (43%), Gaps = 65/359 (18%)
Query: 3 VKVSVFGFGTVGRALAEIIAEKR----------KVFGVELNVVSITDRSGTIWGDF-DLL 51
++V V G G VG AL E I ++ +V G+ + V +T+ G + D L
Sbjct: 466 IEVFVIGVGGVGGALIEQIYRQQPWLKQKHIDLRVCGIANSRVMLTNVHGIALDSWRDAL 525
Query: 52 EAKEVKESTGKLSN-IGEYEVYDFSPQELIEEVKPDILVDVSSWDDAHEMYSYALAEGIS 110
+ + G+L + EY + + ++VD +S + Y LA+G
Sbjct: 526 AGAQEPFNLGRLIRLVKEYHLLN------------PVIVDCTSSQAVADQYVDFLADGFH 573
Query: 111 VVTSNKPPIA---NHYDELITLARENGVGIFFESTVMAGTPIIGLLRENLL--GEEIVKM 165
VVT NK N+Y +L A + +++ V AG P+I L +NLL G+E+V+
Sbjct: 574 VVTPNKKANTSSMNYYQQLRAAAAGSHRKFLYDTNVGAGLPVIENL-QNLLNAGDELVRF 632
Query: 166 EAIVNASTTFILTRMENGKTFEEAMEEARTLGILEEDPSKDIDGIDAYYKAKIL------ 219
I++ S +FI +++ G + A +AR G E DP D+ G+D K IL
Sbjct: 633 SGILSGSLSFIFGKLDEGLSLSAATLQARANGYTEPDPRDDLSGMDVARKLLILAREAGY 692
Query: 220 ---------------HWVSYGE------QPEEEEREGIRNVKDA----RNVRLVAEISKG 254
+ + G+ + E ++E RNV +A + +R V I +G
Sbjct: 693 KLELSDIEVEPVLPPSFDASGDVDTFLARLPELDKEFARNVANAAEQGKVLRYVGLIDEG 752
Query: 255 RISVAPRKLPDNSPLL-VSEVENAALIKT---ENLTLTLKGPGGGGKVTASGVFTDIIK 309
R V + N PL V ENA + + L L L+G G G VTA+GVF D+++
Sbjct: 753 RCKVRIEAVDGNDPLYKVKNGENALAFYSRYYQPLPLVLRGYGAGNDVTAAGVFADLLR 811
>sp|P49080|AKH2_MAIZE BIFUNCTIONAL ASPARTOKINASE/HOMOSERINE DEHYDROGENASE 2, CHLOROPLAST
PRECURSOR (AK-HD 2) (AK-HSDH 2) [INCLUDES: ASPARTOKINASE
; HOMOSERINE DEHYDROGENASE ] >gi|7434567|pir||T02954
aspartate kinase (EC 2.7.2.4) / homoserine dehydrogenase
(EC 1.1.1.3) precursor - maize >gi|500853|gb|AAA74361.1|
(L33913) aspartate kinase-homoserine dehydrogenase [Zea
mays]
Length = 917
Score = 96.0 bits (235), Expect = 5e-19
Identities = 91/360 (25%), Positives = 154/360 (42%), Gaps = 51/360 (14%)
Query: 5 VSVFGFGTVGRALAEIIAEKRKVF----GVELNVVSITDRSGTIWGD--FDLLEAKEVKE 58
V + G G +G AL + + V ++L V+ IT S + D DL + K++ +
Sbjct: 561 VGIIGPGLIGGALLNQLKNQTAVLKENMNIDLRVIGITGSSTMLLSDTGIDLTQWKQLLQ 620
Query: 59 STGKLSNIGEYEVYDFSPQELIEEVKPDILVDVSSWDDAHEMYSYALAEGISVVTSNKPP 118
+ ++IG + V+ S + +LVD ++ Y L +GI V+T NK
Sbjct: 621 KEAEPADIGSF-VHHLSDNHVFPN---KVLVDCTADTSVASHYYDWLKKGIHVITPNKKA 676
Query: 119 IANHYDELI---TLARENGVGIFFESTVMAGTPIIGLLRENL-LGEEIVKMEAIVNASTT 174
+ D+ + T+ R + F+E+TV AG PII LR L G++I+++E I + + +
Sbjct: 677 NSGPLDQYLKLRTMQRASYTHYFYEATVGAGLPIISTLRGLLETGDKILRIEGIFSGTLS 736
Query: 175 FILTRMENGKTFEEAMEEARTLGILEEDPSKDIDGIDAYYKAKILHWVS----------- 223
+I E + F + + EAR G E DP D+ G D K +L S
Sbjct: 737 YIFNNFEGTRAFSDVVAEAREAGYTEPDPRDDLSGTDVARKVVVLARESGLRLELSDIPV 796
Query: 224 ----------------YGEQPEEEEREGIRNVKDA-------RNVRLVAEISKGRISVAP 260
+ ++ + + R DA R V + +++
Sbjct: 797 KSLVPETLASCSSADEFMQKLPSFDEDWARQRSDAEAAGEVLRYVGALDAVNRSGQVELR 856
Query: 261 RKLPDNSPLLVSEVENAALIKT---ENLTLTLKGPGGGGKVTASGVFTDIIKAALKFPSP 317
R D+ +S +N T + L ++GPG G +VTA GVF DI++ A +P
Sbjct: 857 RYRRDHPFAQLSGSDNIIAFTTSRYKEQPLIVRGPGAGAEVTAGGVFCDILRLASYLGAP 916
>dbj|BAA38477.1| (D10386) aspartokinase I-homoserine dehydrogenase I [Serratia
marcescens]
Length = 819
Score = 94.4 bits (231), Expect = 2e-18
Identities = 99/359 (27%), Positives = 159/359 (43%), Gaps = 65/359 (18%)
Query: 3 VKVSVFGFGTVGRALAEIIAEKR----------KVFGVELNVVSITDRSGTIWGDF-DLL 51
++V V G G VG L E I ++ +V G+ + V +T+ G + D L
Sbjct: 466 IEVFVIGVGGVGGTLIEQIYRQQPWLKQKHIDLRVCGIANSRVMLTNVHGIALDSWRDAL 525
Query: 52 EAKEVKESTGKLSN-IGEYEVYDFSPQELIEEVKPDILVDVSSWDDAHEMYSYALAEGIS 110
+ + G+L + EY + + ++VD +S + Y LA+G
Sbjct: 526 AGAQEPFNLGRLIRLVKEYHLLN------------PVIVDCTSSQAVADQYVDFLADGFH 573
Query: 111 VVTSNKPPIA---NHYDELITLARENGVGIFFESTVMAGTPIIGLLRENLL--GEEIVKM 165
VVT NK N+Y +L A + +++ V AG P+I L +NLL G+E+V+
Sbjct: 574 VVTPNKKANTSSMNYYQQLRAAAAGSHRKFLYDTNVGAGLPVIENL-QNLLNAGDELVRF 632
Query: 166 EAIVNASTTFILTRMENGKTFEEAMEEARTLGILEEDPSKDIDGIDAYYKAKIL------ 219
I++ S +FI +++ G + A +AR G E DP D+ G+D K IL
Sbjct: 633 SGILSGSLSFIFGKLDEGLSLSAATLQARANGYTEPDPRDDLSGMDVARKLLILAREAGY 692
Query: 220 ---------------HWVSYGE------QPEEEEREGIRNVKDA----RNVRLVAEISKG 254
+ + G+ + E ++E RNV +A + +R V I +G
Sbjct: 693 KLELSDIEVEPVLPPSFDASGDVDTFLARLPELDKEFARNVANAAEQGKVLRYVGLIDEG 752
Query: 255 RISVAPRKLPDNSPLL-VSEVENAALIKT---ENLTLTLKGPGGGGKVTASGVFTDIIK 309
R V + N PL V ENA + + L L L+G G G VTA+GVF D+++
Sbjct: 753 RCKVRIEAVDGNDPLYKVKNGENALAFYSRYYQPLPLVLRGYGAGNDVTAAGVFADLLR 811
>pir||DEECK thrA bifunctional enzyme - Escherichia coli
>gi|537245|gb|AAA97301.1| (U14003) aspartokinase
I-homoserine dehydrogenase I [Escherichia coli]
>gi|1786183|gb|AAC73113.1| (AE000111) aspartokinase I,
homoserine dehydrogenase I [Escherichia coli K12]
Length = 820
Score = 89.7 bits (219), Expect = 4e-17
Identities = 99/360 (27%), Positives = 158/360 (43%), Gaps = 66/360 (18%)
Query: 3 VKVSVFGFGTVGRALAEIIAEKR----------KVFGVELNVVSITDRSGTIWGDF--DL 50
++V V G G VG AL E + ++ +V GV + +T+ G ++ +L
Sbjct: 466 IEVFVIGVGGVGGALLEQLKRQQSWLKNKHIDLRVCGVANSKALLTNVHGLNLENWQEEL 525
Query: 51 LEAKEVKESTGKLSNIGEYEVYDFSPQELIEEVKPDILVDVSSWDDAHEMYSYALAEGIS 110
+AKE + + EY + + ++VD +S + Y+ L EG
Sbjct: 526 AQAKEPFNLGRLIRLVKEYHLLN------------PVIVDCTSSQAVADQYADFLREGFH 573
Query: 111 VVTSNKPPIAN---HYDELITLARENGVGIFFESTVMAGTPIIGLLRENLL--GEEIVKM 165
VVT NK + +Y +L A ++ +++ V AG P+I L +NLL G+E++K
Sbjct: 574 VVTPNKKANTSSMDYYHQLRYAAEKSRRKFLYDTNVGAGLPVIENL-QNLLNAGDELMKF 632
Query: 166 EAIVNASTTFILTRMENGKTFEEAMEEARTLGILEEDPSKDIDGIDAYYKAKILHWVSYG 225
I++ S ++I +++ G +F EA AR +G E DP D+ G+D K IL +
Sbjct: 633 SGILSGSLSYIFGKLDEGMSFSEATTLAREMGYTEPDPRDDLSGMDVARKLLILARETGR 692
Query: 226 E-----------QPEEEEREG----------------IRNVKDARN----VRLVAEISK- 253
E P E EG V AR+ +R V I +
Sbjct: 693 ELELADIEIEPVLPAEFNAEGDVAAFMANLSQLDDLFAARVAKARDEGKVLRYVGNIDED 752
Query: 254 GRISVAPRKLPDNSPLL-VSEVENAALIKT---ENLTLTLKGPGGGGKVTASGVFTDIIK 309
G V ++ N PL V ENA + + L L L+G G G VTA+GVF D+++
Sbjct: 753 GVCRVKIAEVDGNDPLFKVKNGENALAFYSHYYQPLPLVLRGYGAGNDVTAAGVFADLLR 812
>sp|P37142|AKH_DAUCA BIFUNCTIONAL ASPARTOKINASE/HOMOSERINE DEHYDROGENASE, CHLOROPLAST
PRECURSOR (AK-HD) (AK-HSDH) [INCLUDES: ASPARTOKINASE ;
HOMOSERINE DEHYDROGENASE ] >gi|486738|pir||S35160
aspartate kinase (EC 2.7.2.4) / homoserine dehydrogenase
(EC 1.1.1.3) precursor - carrot
>gi|464225|gb|AAA16972.1| (L11529)
aspartokinase-homoserine dehydrogenase [Daucus carota]
Length = 921
Score = 89.7 bits (219), Expect = 4e-17
Identities = 86/362 (23%), Positives = 157/362 (42%), Gaps = 51/362 (14%)
Query: 3 VKVSVFGFGTVGRALAEIIAEKRKVFG----VELNVVSITDRSGTIWGD--FDLLEAKEV 56
+ V + G G +G L + + ++ + ++L V+ IT + + DL +EV
Sbjct: 563 IAVGIVGPGLIGATLLDQLRDQAAILKENSKIDLRVMGITGSRTMLLSETGIDLSRWREV 622
Query: 57 KESTGKLSNIGEYEVYDFSPQELIEEVKPDILVDVSSWDDAHEMYSYALAEGISVVTSNK 116
++ G+ + + ++ V I ++VD ++ + Y L GI V+T NK
Sbjct: 623 QKEKGQTAGLEKF-VQHVRGNHFIPST---VIVDCTADSEVASHYHDWLCRGIHVITPNK 678
Query: 117 PPIANHYDELI---TLARENGVGIFFESTVMAGTPIIGLLRENL-LGEEIVKMEAIVNAS 172
+ D+ + L R + F+E+TV+AG PII L+ L G++I+++E I + +
Sbjct: 679 KANSGPLDQYLKLRALQRRSYTHYFYEATVVAGLPIITTLQGLLETGDKILRIEGIFSGT 738
Query: 173 TTFILTRMENGKTFEEAMEEARTLGILEEDPSKDIDGIDAYYKAKI-------------- 218
++I ++ F E + EA+ G E DP D+ G D K I
Sbjct: 739 LSYIFNNFKSTTPFSEVVSEAKAAGYTEPDPRDDLAGTDVARKVIILARGSGLKLELSDI 798
Query: 219 ---------LHWVSYGE----QPEEEEREGIRNVKDARN-------VRLVAEISKGRISV 258
L ++ E Q + + + R +DA N V +V +++ +
Sbjct: 799 PVQSLVPEPLRGIASAEEFLLQLPQFDSDMTRKREDAENAGEVLRYVGVVDAVNQKGVVE 858
Query: 259 APRKLPDNSPLLVSEVENAALIKTENLTL---TLKGPGGGGKVTASGVFTDIIKAALKFP 315
R ++ +S +N TE ++GPG G +VTA GVF+DI++ A
Sbjct: 859 LKRYKKEHPFAQLSGSDNINAFTTERYNKQPPIIRGPGAGAEVTAGGVFSDILRLASYLG 918
Query: 316 SP 317
+P
Sbjct: 919 AP 920
>pir||T04752 aspartate kinase (EC 2.7.2.4) / homoserine dehydrogenase (EC
1.1.1.3) T16H5.70 - Arabidopsis thaliana
>gi|3250680|emb|CAA19688.1| (AL024486) aspartate
kinase-homoserine dehydrogenase-like protein
[Arabidopsis thaliana] >gi|7268767|emb|CAB78973.1|
(AL161551) aspartate kinase-homoserine
dehydrogenase-like protein [Arabidopsis thaliana]
Length = 916
Score = 87.8 bits (214), Expect = 1e-16
Identities = 92/364 (25%), Positives = 157/364 (42%), Gaps = 59/364 (16%)
Query: 5 VSVFGFGTVGRALAEIIAEKRKV----FGVELNVVSITDRSGTIWGDF--DLLEAKEVKE 58
+ + G G +G L + + ++ V F ++L V+ IT + D DL +E+
Sbjct: 560 MGIVGPGLIGATLLDQLRDQAAVLKQEFNIDLRVLGITGSKKMLLSDIGIDLSRWRELLN 619
Query: 59 STGKLSNIGEY--EVYD--FSPQELIEEVKPDILVDVSSWDDAHEMYSYALAEGISVVTS 114
G +++ ++ +V+ F P ++ + D + A Y + L +GI V+T
Sbjct: 620 EKGTEADLDKFTQQVHGNHFIPNSVVVDCTADSAI-------ASRYYDW-LRKGIHVITP 671
Query: 115 NKPPIANHYDELITLA---RENGVGIFFESTVMAGTPIIGLLRENL-LGEEIVKMEAIVN 170
NK + D+ + L R++ F+E+TV AG PII LR L G++I+++E I +
Sbjct: 672 NKKANSGPLDQYLKLRDLQRKSYTHYFYEATVGAGLPIISTLRGLLETGDKILRIEGICS 731
Query: 171 ASTTFILTRMENGKTFEEAMEEARTLGILEEDPSKDIDGIDAYYKAKILHWVS-----YG 225
+ +++ ++F E + EA+ G E DP D+ G D K IL S
Sbjct: 732 GTLSYLFNNFVGDRSFSEVVTEAKNAGFTEPDPRDDLSGTDVARKVIILARESGLKLDLA 791
Query: 226 EQP----EEEEREGIRNVK-----------DARNVRLVAEIS---------------KGR 255
+ P E +G +V+ D RL AE S KG
Sbjct: 792 DLPIRSLVPEPLKGCTSVEEFMEKLPQYDGDLAKERLDAENSGEVLRYVGVVDAVNQKGT 851
Query: 256 ISVAPRKLPDNSPLLVSEVENAALIKT--ENLTLTLKGPGGGGKVTASGVFTDIIKAALK 313
+ + K L A T ++ L ++GPG G +VTA G+F+DI++ A
Sbjct: 852 VELRRYKKEHPFAQLAGSDNIIAFTTTRYKDHPLIVRGPGAGAQVTAGGIFSDILRLASY 911
Query: 314 FPSP 317
+P
Sbjct: 912 LGAP 915
>emb|CAA23660.1| (V00361) thrA gene [EC 2.7.2.4 and EC 1.1.1.3] [Escherichia coli]
>gi|147979|gb|AAA83914.1| (J01706) aspartokinase
I-homoserine dehydrogenase I [Escherichia coli]
>gi|216435|dbj|BAA01286.1| (D10483) aspartokinase I
[Escherichia coli]
Length = 820
Score = 87.0 bits (212), Expect = 3e-16
Identities = 98/360 (27%), Positives = 157/360 (43%), Gaps = 66/360 (18%)
Query: 3 VKVSVFGFGTVGRALAEIIAEKR----------KVFGVELNVVSITDRSGTIWGDF--DL 50
++V V G G VG AL E + ++ +V GV + +T+ G ++ +L
Sbjct: 466 IEVFVIGVGGVGGALLEQLKRQQSWLKNKHIDLRVCGVANSKALLTNVHGLNLENWQEEL 525
Query: 51 LEAKEVKESTGKLSNIGEYEVYDFSPQELIEEVKPDILVDVSSWDDAHEMYSYALAEGIS 110
+AKE + + EY + + ++V+ +S + Y+ L EG
Sbjct: 526 AQAKEPFNLGRLIRLVKEYHLLN------------PVIVNCTSSQAVADQYADFLREGFH 573
Query: 111 VVTSNKPPIAN---HYDELITLARENGVGIFFESTVMAGTPIIGLLRENLL--GEEIVKM 165
VVT NK + +Y +L A ++ ++ V AG P+I L +NLL G+E++K
Sbjct: 574 VVTPNKKANTSSMDYYHQLRYAAEKSRRKFLYDINVGAGLPVIENL-QNLLNAGDELMKF 632
Query: 166 EAIVNASTTFILTRMENGKTFEEAMEEARTLGILEEDPSKDIDGIDAYYKAKILHWVSYG 225
I++ S ++I +++ G +F EA AR +G E DP D+ G+D K IL +
Sbjct: 633 SGILSGSLSYIFGKLDEGMSFSEATRLAREMGYTEPDPRDDLSGMDVARKLLILARETGR 692
Query: 226 E-----------QPEEEEREG----------------IRNVKDARN----VRLVAEISK- 253
E P E EG V AR+ +R V I +
Sbjct: 693 ELELADIEIEPVLPAEFNAEGDVAAFMANLSQLDDLFAARVAKARDEGKVLRYVGNIDED 752
Query: 254 GRISVAPRKLPDNSPLL-VSEVENAALIKT---ENLTLTLKGPGGGGKVTASGVFTDIIK 309
G V ++ N PL V ENA + + L L L+G G G VTA+GVF D+++
Sbjct: 753 GVCRVKIAEVDGNDPLFKVKNGENALAFYSHYYQPLPLVLRGYGAGNDVTAAGVFADLLR 812
>sp|P00561|AK1H_ECOLI BIFUNCTIONAL ASPARTOKINASE/HOMOSERINE DEHYDROGENASE I (AKI-HDI)
[INCLUDES: ASPARTOKINASE I ; HOMOSERINE DEHYDROGENASE I
]
Length = 820
Score = 87.0 bits (212), Expect = 3e-16
Identities = 98/360 (27%), Positives = 157/360 (43%), Gaps = 66/360 (18%)
Query: 3 VKVSVFGFGTVGRALAEIIAEKR----------KVFGVELNVVSITDRSGTIWGDF--DL 50
++V V G G VG AL E + ++ +V GV + +T+ G ++ +L
Sbjct: 466 IEVFVIGVGGVGGALLEQLKRQQSWLKNKHIDLRVCGVANSKALLTNVHGLNLENWQEEL 525
Query: 51 LEAKEVKESTGKLSNIGEYEVYDFSPQELIEEVKPDILVDVSSWDDAHEMYSYALAEGIS 110
+AKE + + EY + + ++V+ +S + Y+ L EG
Sbjct: 526 AQAKEPFNLGRLIRLVKEYHLLN------------PVIVNCTSSQAVADQYADFLREGFH 573
Query: 111 VVTSNKPPIAN---HYDELITLARENGVGIFFESTVMAGTPIIGLLRENLL--GEEIVKM 165
VVT NK + +Y +L A ++ ++ V AG P+I L +NLL G+E++K
Sbjct: 574 VVTPNKKANTSSMDYYHQLRYAAEKSRRKFLYDINVGAGLPVIENL-QNLLNAGDELMKF 632
Query: 166 EAIVNASTTFILTRMENGKTFEEAMEEARTLGILEEDPSKDIDGIDAYYKAKILHWVSYG 225
I++ S ++I +++ G +F EA AR +G E DP D+ G+D K IL +
Sbjct: 633 SGILSGSLSYIFGKLDEGMSFSEATRLAREMGYTEPDPRDDLSGMDVARKLLILARETGR 692
Query: 226 E-----------QPEEEEREG----------------IRNVKDARN----VRLVAEISK- 253
E P E EG V AR+ +R V I +
Sbjct: 693 ELELADIEIEPVLPAEFNAEGDVAAFMANLSQLDDLFAARVAKARDEGKVLRYVGNIDED 752
Query: 254 GRISVAPRKLPDNSPLL-VSEVENAALIKT---ENLTLTLKGPGGGGKVTASGVFTDIIK 309
G V ++ N PL V ENA + + L L L+G G G VTA+GVF D+++
Sbjct: 753 GVCRVKIAEVDGNDPLFKVKNGENALAFYSHYYQPLPLVLRGYGAGNDVTAAGVFADLLR 812
>gi|6322599 Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase); Hom6p
[Saccharomyces cerevisiae]
>gi|399368|sp|P31116|DHOM_YEAST HOMOSERINE DEHYDROGENASE
(HDH) >gi|485487|pir||S33317 homoserine dehydrogenase
(EC 1.1.1.3) - yeast (Saccharomyces cerevisiae)
>gi|3797|emb|CAA45787.1| (X64457) homoserine
dehydrogenase [Saccharomyces cerevisiae]
>gi|1015880|emb|CAA89671.1| (Z49639) ORF YJR139c
[Saccharomyces cerevisiae]
Length = 359
Score = 87.0 bits (212), Expect = 3e-16
Identities = 92/354 (25%), Positives = 152/354 (41%), Gaps = 48/354 (13%)
Query: 3 VKVSVFGFGTVGRALAEIIAEKRKVFGVELNVVSITDRSGTIWGDFDLLEAKEVKESTGK 62
V V+V G G VG A + + + L +++ +RS I DF L ++
Sbjct: 6 VNVAVIGAGVVGSAFLDQLLAMKSTITYNLVLLAEAERS-LISKDFSPLNVGSDWKAALA 64
Query: 63 LSNIGEYEVYDFSPQELIEEVKPDILVDVSSWDDAHEMYSYALAEGISVVTSNKPPIANH 122
S + D L KP ILVD +S Y+ + GIS+ T NK ++
Sbjct: 65 ASTTKTLPLDDLIAH-LKTSPKPVILVDNTSSAYIAGFYTKFVENGISIATPNKKAFSSD 123
Query: 123 ---YDELITLARENGVGIFFESTVMAGTPIIGLLRENL-LGEEIVKMEAIVNASTTFIL- 177
+ L + NG ++ E+TV AG PII LRE + G+E+ K+E I + + ++I
Sbjct: 124 LATWKALFSNKPTNGF-VYHEATVGAGLPIISFLREIIQTGDEVEKIEGIFSGTLSYIFN 182
Query: 178 ---TRMENGKTFEEAMEEARTLGILEEDPSKDIDGIDAYYKAKILHWVS----------- 223
T N F + ++ A+ LG E DP D++G+D K I+ +S
Sbjct: 183 EFSTSQANDVKFSDVVKVAKKLGYTEPDPRDDLNGLDVARKVTIVGRISGVEVESPTSFP 242
Query: 224 -----------------YGEQPEEEEREGIRNVKDARNVRLV------AEISKGRISVAP 260
+ E+ + +++ + K+A V +++ +SV
Sbjct: 243 VQSLIPKPLESVKSADEFLEKLSDYDKDLTQLKKEAATENKVLRFIGKVDVATKSVSVGI 302
Query: 261 RKLPDNSPLL-VSEVENAALIKTENLT--LTLKGPGGGGKVTASGVFTDIIKAA 311
K + P + +N IKT+ T + ++G G G VTA+GV D+IK A
Sbjct: 303 EKYDYSHPFASLKGSDNVISIKTKRYTNPVVIQGAGAGAAVTAAGVLGDVIKIA 356
>pdb|1EBF|A Chain A, Homoserine Dehydrogenase From S. Cerevisiae Complex With
Nad+ >gi|7245385|pdb|1EBF|B Chain B, Homoserine
Dehydrogenase From S. Cerevisiae Complex With Nad+
>gi|7245386|pdb|1EBU|A Chain A, Homoserine Dehydrogenase
Complex With Nad Analogue And L- Homoserine
>gi|7245387|pdb|1EBU|B Chain B, Homoserine Dehydrogenase
Complex With Nad Analogue And L- Homoserine
>gi|7245388|pdb|1EBU|C Chain C, Homoserine Dehydrogenase
Complex With Nad Analogue And L- Homoserine
>gi|7245389|pdb|1EBU|D Chain D, Homoserine Dehydrogenase
Complex With Nad Analogue And L- Homoserine
Length = 358
Score = 87.0 bits (212), Expect = 3e-16
Identities = 92/354 (25%), Positives = 152/354 (41%), Gaps = 48/354 (13%)
Query: 3 VKVSVFGFGTVGRALAEIIAEKRKVFGVELNVVSITDRSGTIWGDFDLLEAKEVKESTGK 62
V V+V G G VG A + + + L +++ +RS I DF L ++
Sbjct: 5 VNVAVIGAGVVGSAFLDQLLAMKSTITYNLVLLAEAERS-LISKDFSPLNVGSDWKAALA 63
Query: 63 LSNIGEYEVYDFSPQELIEEVKPDILVDVSSWDDAHEMYSYALAEGISVVTSNKPPIANH 122
S + D L KP ILVD +S Y+ + GIS+ T NK ++
Sbjct: 64 ASTTKTLPLDDLIAH-LKTSPKPVILVDNTSSAYIAGFYTKFVENGISIATPNKKAFSSD 122
Query: 123 ---YDELITLARENGVGIFFESTVMAGTPIIGLLRENL-LGEEIVKMEAIVNASTTFIL- 177
+ L + NG ++ E+TV AG PII LRE + G+E+ K+E I + + ++I
Sbjct: 123 LATWKALFSNKPTNGF-VYHEATVGAGLPIISFLREIIQTGDEVEKIEGIFSGTLSYIFN 181
Query: 178 ---TRMENGKTFEEAMEEARTLGILEEDPSKDIDGIDAYYKAKILHWVS----------- 223
T N F + ++ A+ LG E DP D++G+D K I+ +S
Sbjct: 182 EFSTSQANDVKFSDVVKVAKKLGYTEPDPRDDLNGLDVARKVTIVGRISGVEVESPTSFP 241
Query: 224 -----------------YGEQPEEEEREGIRNVKDARNVRLV------AEISKGRISVAP 260
+ E+ + +++ + K+A V +++ +SV
Sbjct: 242 VQSLIPKPLESVKSADEFLEKLSDYDKDLTQLKKEAATENKVLRFIGKVDVATKSVSVGI 301
Query: 261 RKLPDNSPLL-VSEVENAALIKTENLT--LTLKGPGGGGKVTASGVFTDIIKAA 311
K + P + +N IKT+ T + ++G G G VTA+GV D+IK A
Sbjct: 302 EKYDYSHPFASLKGSDNVISIKTKRYTNPVVIQGAGAGAAVTAAGVLGDVIKIA 355
>sp|P57290|AKH_BUCAI BIFUNCTIONAL ASPARTOKINASE/HOMOSERINE DEHYDROGENASE (AK-HD)
[INCLUDES: ASPARTOKINASE ; HOMOSERINE DEHYDROGENASE ]
>gi|10038876|dbj|BAB12911.1| (AP001118) aspartokinase I
/ homoserine dehydrogenase I [Buchnera sp. APS]
Length = 816
Score = 85.4 bits (208), Expect = 8e-16
Identities = 96/359 (26%), Positives = 158/359 (43%), Gaps = 64/359 (17%)
Query: 3 VKVSVFGFGTVGRALAEIIAEKRKVF---GVELNVVSITDRSGTIWGDF--DLLEAK-EV 56
+ + + G G +G L I ++++ +E+ + +I + + D DL K +
Sbjct: 467 IHMFLIGIGGIGSTLLNQILKQKQFLDKKNIEIKICAIANSKKILLLDNTNDLSNWKNDF 526
Query: 57 KESTGK-----LSNIGEYEVYDFSPQELIEEVKPDILVDVSSWDDAHEMYSYALAEGISV 111
K+ST K L+N+ + + S ++VD +S E Y + V
Sbjct: 527 KKSTQKFNLELLNNLIKNNHFSNS-----------VIVDCTSSQLLSEQYVNFIDNNFHV 575
Query: 112 VTSNKPPIA---NHYDELITLARENGVGIFFESTVMAGTPIIGLLRENLL--GEEIVKME 166
VTSNK N+Y ++ + G +E+ V AG P+I L +NL G+ ++ +
Sbjct: 576 VTSNKKANTSEWNYYKKIRKSVAQTGKKFLYETNVGAGLPVIETL-QNLFKSGDNLICFK 634
Query: 167 AIVNASTTFILTRMENGKTFEEAMEEARTLGILEEDPSKDIDGIDAYYKAKILHWVS-YG 225
I++ S +FI R+E G +A EA+ LG E +P D+ GID K IL S Y
Sbjct: 635 GILSGSLSFIFGRLEEGILLSQATREAKELGFTEPNPCDDLSGIDVARKLLILARESGYN 694
Query: 226 EQPEEEEREGI--------------------------RNVKDARNV----RLVAEI-SKG 254
+ ++ + E + +K A NV R VA I K
Sbjct: 695 IELKDIKIEPLLPNNFKIYEDTDKFLLKLKELDVYFSNKIKQALNVGNVLRFVATIEQKR 754
Query: 255 RISVAPRKLPDNSPLL-VSEVENAALIKT---ENLTLTLKGPGGGGKVTASGVFTDIIK 309
+ + ++ N+PL V ENA T + + L L+G G G VTASGVF+D+++
Sbjct: 755 QFFIKLEEVNINNPLYKVKNGENALAFYTNYYQPIPLVLRGYGAGNNVTASGVFSDLLR 813
>pir||T03589 probable aspartate kinase (EC 2.7.2.4) / homoserine dehydrogenase
(EC 1.1.1.3) precursor - rice
>gi|1777375|dbj|BAA11417.1| (D78573) aspartate
kinase-homoserine dehydrogenase [Oryza sativa]
Length = 915
Score = 83.9 bits (204), Expect = 2e-15
Identities = 89/361 (24%), Positives = 153/361 (41%), Gaps = 53/361 (14%)
Query: 5 VSVFGFGTVGRALAEIIAEKRKVF----GVELNVVSITDRSGTIWGDF--DLLEAKEVKE 58
V + G G +G L + + ++ V ++L V+ I+ D DL + K++
Sbjct: 559 VGIIGPGLIGGTLLDQLKDQAAVLKENMNIDLRVIGISGSRTMHLSDIGVDLNQWKDLLR 618
Query: 59 STGKLSNIGEYEVYDFSPQELIEEVKPDILVDVSSWDDAHEMYSYALAEGISVVTSNKPP 118
+ +++ + V S + +LVD ++ Y L +GI V+T NK
Sbjct: 619 KEAEPADLDSF-VRHLSENHVFPN---KVLVDCTADTYVACHYYDWLKKGIHVITPNKKA 674
Query: 119 IA---NHYDELITLARENGVGIFFESTVMAGTPIIGLLRENL-LGEEIVKMEAIVNASTT 174
+ + Y +L TL R + F+E+TV AG PII LR L G++I+++E I + + +
Sbjct: 675 NSGPLDRYLKLRTLQRASYTHYFYEATVGAGLPIISTLRGLLETGDKILRIEGIFSGTLS 734
Query: 175 FILTRMENGKTFEEAMEEARTLGILEEDPSKDIDGIDAYYKAKIL--------------- 219
+I E +TF + EA+ G E DP D+ G D K IL
Sbjct: 735 YIFNNFEGTRTFSNVVAEAKEAGYTEPDPRDDLSGTDVARKVIILARESGLRLELSDIPV 794
Query: 220 ------------------HWVSYGEQPEEEEREGIRNVKDARNVRLVAEIS--KGRISVA 259
+ +Q + +R+ + V +++ KGR+ +
Sbjct: 795 KSLLPEALRSCSSADEFMQKLPSFDQDWDRQRDEAEAAGEVLRYVGVVDVANRKGRVEL- 853
Query: 260 PRKLPDNSPLLVSEVENAALIKT---ENLTLTLKGPGGGGKVTASGVFTDIIKAALKFPS 316
R D+ +S +N T + L ++GPG G +VTA GVF DI++ A +
Sbjct: 854 QRYKRDHPFAQLSGSDNIIAFTTSRYKEQPLIVRGPGAGAEVTAGGVFCDILRLASYLGA 913
Query: 317 P 317
P
Sbjct: 914 P 914
>pir||T40673 homoserine dehydrogenase - fission yeast (Schizosaccharomyces
pombe) >gi|4176520|emb|CAA22876.1| (AL035263) homoserine
dehydrogenase [Schizosaccharomyces pombe]
Length = 376
Score = 83.9 bits (204), Expect = 2e-15
Identities = 98/359 (27%), Positives = 156/359 (43%), Gaps = 55/359 (15%)
Query: 3 VKVSVFGFGTVGRALAEIIA---EKRKVFGV-ELNVVSITDRSGT-IWGDFDLLEAKEVK 57
V V++ G G +G L I E G NVV+I+ G + D+ + E K
Sbjct: 8 VNVAIVGTGNIGGELLNQIKGFNENASTNGTTSFNVVAISSMEGHYVSKDYQPINLSEWK 67
Query: 58 ESTGKLSNIGEYEVYDFSPQELIEEVKPDILVDVSSWDDAHEMYSYALAEGISVVTSNKP 117
T + N G Y + D L + P ILVD ++ + + Y L++ I++ T NK
Sbjct: 68 NLTSQ--NQGAYSL-DALVDFLAKSPLPAILVDNTASEAIAQSYPKFLSKKINIATPNKK 124
Query: 118 PIA---NHYDELITLARENGVGIFFESTVMAGTPIIGLLRENL-LGEEIVKMEAIVNAST 173
+ + Y +I ++E+G + E++V AG PII L+E + G+EI+K+E I + +
Sbjct: 125 AFSASNDVYQNIIKASKESGALLMHEASVGAGLPIISTLKELIATGDEIIKIEGIFSGTL 184
Query: 174 TFILTRME-NGK----TFEEAMEEARTLGILEEDPSKDIDGIDAYYKAKIL------HWV 222
++I NGK +F + ++ A+ G E DP D++G+D K IL H
Sbjct: 185 SYIFNVWSPNGKKGTASFSDIVKIAKQNGYTEPDPRDDLNGMDVARKVTILSRIAGVHVE 244
Query: 223 SYGEQP--------------EEEEREGIRNV------------KDARNVRLV--AEISKG 254
S P EE G+ N K+ + VR V A+++
Sbjct: 245 SASSFPVKSLIPEPLKSAVNAEEFLAGLPNFDSEFASMREEAEKEGKVVRFVGEADVANK 304
Query: 255 RISVAPRKLPDNSPLL-VSEVENAALIKTENL---TLTLKGPGGGGKVTASGVFTDIIK 309
V K + P + +N T+ L + G G G VTA+GV D+IK
Sbjct: 305 TTLVKLEKYDASHPFANLQSSDNIISFTTKRYHTRPLVVIGAGAGAAVTAAGVLGDMIK 363
>pir||G82583 bifunctional aspartokinase/homoserine dehydrogenase I XF2225
[imported] - Xylella fastidiosa (strain 9a5c)
>gi|9107374|gb|AAF85024.1|AE004035_3 (AE004035)
bifunctional aspartokinase/homoserine dehydrogenase I
[Xylella fastidiosa]
Length = 828
Score = 82.7 bits (201), Expect = 5e-15
Identities = 68/264 (25%), Positives = 122/264 (45%), Gaps = 39/264 (14%)
Query: 87 ILVDVSSWDDAHEMYSYALAEGISVVTSNKPPIA---NHYDELITLARENGVGIFFESTV 143
+++D S + + Y+ LA GI VVT NK + + Y + A +G +E+TV
Sbjct: 558 VIIDCSGSAEVADRYADWLAAGIHVVTPNKQAGSGPLHRYHAIRAAADASGARFRYEATV 617
Query: 144 MAGTPIIGLLRENL-LGEEIVKMEAIVNASTTFILTRMENGKTFEEAMEEARTLGILEED 202
AG P+I LR+ + G+ + +E I + + ++ + + F + + +AR +G E D
Sbjct: 618 GAGLPVITTLRDLMDTGDSVTSIEGIFSGTLAWLFNKYDGSVPFSQLITQARAMGYTEPD 677
Query: 203 PSKDIDGIDAYYKAKIL-----------------------------HWVSYGEQPEEEER 233
P D+ G+D K IL +++ + +
Sbjct: 678 PRDDLSGVDVARKLVILARDAGRDISLEDVAVESLVPETLCQLSVADFMARLNEVDATFA 737
Query: 234 EGIRNVKDARNV-RLVAEISKGRI-SVAPRKLP-DNSPLLVSEVENAALIKTENLT---L 287
E + K V R VA++S G + SV+ +LP D++ + + +N T + L
Sbjct: 738 ERLAAAKQRGCVLRYVAQLSPGHVPSVSLIELPSDHAFVNLRLTDNVVQFTTRRYSENPL 797
Query: 288 TLKGPGGGGKVTASGVFTDIIKAA 311
++GPG G +VTA+GVF D+++ A
Sbjct: 798 VVQGPGAGPEVTAAGVFADLLRVA 821
>sp|P29365|DHOM_PSEAE HOMOSERINE DEHYDROGENASE (HDH) >gi|65916|pir||DEPSHA homoserine
dehydrogenase (EC 1.1.1.3) - Pseudomonas aeruginosa
>gi|45329|emb|CAA46167.1| (X65033) homoserine
dehydrogenase [Pseudomonas aeruginosa]
Length = 439
Score = 80.4 bits (195), Expect = 3e-14
Identities = 72/228 (31%), Positives = 109/228 (47%), Gaps = 18/228 (7%)
Query: 99 EMYSYALAEGISVVTSNKPPIANHYDELITLARENGVGIFFESTVMAGTPIIGLLRENLL 158
E+ A+ G VVT+NK IA H + G FE+ V G P+I +RE L
Sbjct: 91 ELVLKAIENGKHVVTANKALIAVHGSRDLRQGPREGRDRAFEAAVAGGIPVIKAIREGLS 150
Query: 159 GEEIVKMEAIVNASTTFILTRM-ENGKTFEEAMEEARTLGI-LEEDPSKDIDGIDAYYKA 216
I + I+N + FIL+ M E G+TF + + EA+ LG P+ D++GIDA K
Sbjct: 151 ANRINWLAGIINGTGNFILSEMREKGRTFPDVLAEAQALGYGRGRSPTFDVEGIDAATKL 210
Query: 217 KIL-HWVSYGEQPEEEEREGIR-------NVKDARNVRL----VAEISKG--RISVAPRK 262
IL + + Q ++ EGI N DA R+ VA ++ + V P
Sbjct: 211 TILASMLRHPLQFDKAYTEGISKLTSADVNYADALGYRIKHLGVARRTESGFELRVHPTL 270
Query: 263 LPDNSPLL-VSEVENAALIKTENLTLTL-KGPGGGGKVTASGVFTDII 308
+P + + V+ V NA ++ + + TL G G G + TAS V D++
Sbjct: 271 IPSDRLIANVTAVMNAVMVNGDAVGSTLYYGAGAGMEPTASSVVADLV 318
>sp|P37144|DHON_METGL HOMOSERINE DEHYDROGENASE (HDH) >gi|2160268|dbj|BAA40415.1| (D14071)
homoserine dehydrogenase [Methylobacillus glycogenes]
Length = 412
Score = 79.6 bits (193), Expect = 4e-14
Identities = 60/223 (26%), Positives = 106/223 (46%), Gaps = 23/223 (10%)
Query: 3 VKVSVFGFGTVGRALAEIIAEKRKVF----GVELNVVSITDRSGTIWGDFDLLEAKEVKE 58
+ V + G GTVG ++ ++ G + + + DR+ + ++
Sbjct: 4 INVGLLGIGTVGGGTYTVLTRNQEEIARRAGRPIAITRVADRNLEL-----------ARQ 52
Query: 59 STGKLSNIGEYEVYDFSPQELIEEVKPDILVD-VSSWDDAHEMYSYALAEGISVVTSNKP 117
TG G+ +V D ++ + DI+V+ + + A E+ A+ G VVT+NK
Sbjct: 53 VTG-----GKIDVTD-DAFAIVSDPAIDIVVELIGGYTVARELVLKAIENGKHVVTANKA 106
Query: 118 PIANHYDELITLARENGVGIFFESTVMAGTPIIGLLRENLLGEEIVKMEAIVNASTTFIL 177
IA + + L R+ + ++ +P+ +RE L I + I+N +T FIL
Sbjct: 107 LIACMAMKFLPLRRKKASSSLLKLPLLVVSPLFKAVREGLAANRIEWIAGIINGTTNFIL 166
Query: 178 TRM-ENGKTFEEAMEEARTLGILEEDPSKDIDGIDAYYKAKIL 219
+ M E G F + ++EA+ LG E DP+ D++GIDA +K IL
Sbjct: 167 SEMREKGLAFADVLKEAQRLGYAEADPTFDVEGIDAAHKLMIL 209
>emb|CAB59717.1| (AL132707) putative homoserine dehydrogenase [Streptomyces
coelicolor A3(2)]
Length = 344
Score = 75.7 bits (183), Expect = 6e-13
Identities = 45/127 (35%), Positives = 64/127 (49%)
Query: 104 ALAEGISVVTSNKPPIANHYDELITLARENGVGIFFESTVMAGTPIIGLLRENLLGEEIV 163
AL GI VVT+ K + H+ +L AR G I A P L R +L G +
Sbjct: 114 ALRRGIHVVTATKSHLLTHWRDLDAAARAGGSMIRISGATGAALPAGDLSRTSLRGLDCR 173
Query: 164 KMEAIVNASTTFILTRMENGKTFEEAMEEARTLGILEEDPSKDIDGIDAYYKAKILHWVS 223
+ A N + TF+L R+ G T +A+ A+ GI E DPS D+ G DA K ++L ++
Sbjct: 174 TIRACPNGTATFVLDRLAEGDTLGDAIRAAQLRGIAEADPSADLSGDDAATKVRLLAALA 233
Query: 224 YGEQPEE 230
+G P E
Sbjct: 234 WGWDPAE 240
Database: ./suso.pep
Posted date: Jul 6, 2001 5:57 PM
Number of letters in database: 840,471
Number of sequences in database: 2977
Database: /banques/blast2/nr.pep
Posted date: Dec 14, 2000 12:46 PM
Number of letters in database: 188,266,275
Number of sequences in database: 595,510
Lambda K H
0.314 0.135 0.372
Gapped
Lambda K H
0.270 0.0470 0.230
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 115773883
Number of Sequences: 2977
Number of extensions: 4919483
Number of successful extensions: 11579
Number of sequences better than 1.0e-10: 57
Number of HSP's better than 0.0 without gapping: 10
Number of HSP's successfully gapped in prelim test: 47
Number of HSP's that attempted gapping in prelim test: 11419
Number of HSP's gapped (non-prelim): 85
length of query: 318
length of database: 189,106,746
effective HSP length: 60
effective length of query: 258
effective length of database: 153,197,526
effective search space: 39524961708
effective search space used: 39524961708
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 42 (21.9 bits)
S2: 165 (68.7 bits)