BLASTP 2.0.10 [Aug-26-1999]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= PAB0724 (PAB0724) DE:MULTIDRUG RESISTANCE PROTEIN
(MULTIDRUG-EFFLUX TRANSPORTER)
(418 letters)
Database: ./suso.pep; /banques/blast2/nr.pep
598,487 sequences; 189,106,746 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
pir||B75087 multidrug resistance protein (multidrug-ef flux tran... 817 0.0
pir||D75093 macrolide-efflux determinant related PAB0754 - Pyroc... 374 e-102
pir||C71050 probable macrolide-efflux determinant - Pyrococcus h... 371 e-102
pir||D72388 hypothetical protein TM0342 - Thermotoga maritima (s... 290 2e-77
pir||H72265 hypothetical protein TM1336 - Thermotoga maritima (s... 180 2e-44
gb|AAC44785.1| (U70055) macrolide-efflux protein [Streptococcus ... 131 1e-29
dbj|BAA89223.1| (AB011259) macrolide-efflux pump [Streptococcus ... 131 2e-29
gb|AAB41436.1| (U83667) macrolide-efflux determinant [Streptococ... 131 2e-29
emb|CAA10866.1| (AJ222587) YkuC protein [Bacillus subtilis] 109 6e-23
pir||H69864 macrolide-efflux protein homolog ykuC - Bacillus sub... 108 1e-22
dbj|BAB05758.1| (AP001514) unknown conserved protein in others [... 107 2e-22
dbj|BAB07605.1| (AP001520) multidrug-efflux transporter [Bacillu... 107 3e-22
emb|CAA63510.1| (X92946) macrolide efflux protein [Lactococcus l... 103 3e-21
gb|AAD42406.1|AF157493_14 (AF157493) putative transporter [Zymom... 101 1e-20
dbj|BAB04012.1| (AP001508) unknown conserved protein [Bacillus h... 101 2e-20
emb|CAA03986.1| (AJ000283) Tap protein [Mycobacterium fortuitum] 93 5e-18
sp|Q11060|YC58_MYCTU HYPOTHETICAL 43.3 KDA PROTEIN RV1258C >gi|7... 93 7e-18
gb|AAB84282.1| (AF030344) tetracycline-resistance determinant te... 93 7e-18
pir||C70046 macrolide-efflux protein homolog yvqJ - Bacillus sub... 93 7e-18
pir||T28700 hypothetical protein - Streptomyces coelicolor >gi|3... 92 9e-18
gb|AAF74725.1|AF251288_2 (AF251288) MefEn2 [Bacteroides fragilis] 90 3e-17
pir||S74444 hypothetical protein sll1204 - Synechocystis sp. (st... 90 6e-17
dbj|BAB12240.1| (AB038042) Mrx [Escherichia coli] 88 2e-16
pir||G75408 probable transport protein - Deinococcus radiodurans... 87 3e-16
pir||H69812 conserved hypothetical protein yfmI - Bacillus subti... 85 2e-15
pir||E69804 multidrug resistance protein homolog yfiS - Bacillus... 85 2e-15
pir||B75051 hypothetical protein PAB1450 - Pyrococcus abyssi (st... 83 4e-15
pir||S77010 nickel resistance protein nreB - Synechocystis sp. (... 83 7e-15
dbj|BAB04526.1| (AP001509) unknown conserved protein [Bacillus h... 82 1e-14
emb|CAB93411.1| (AL357524) putative integral membrane efflux pro... 82 1e-14
pir||T45097 hypothetical protein [imported] - Mycobacterium smeg... 81 2e-14
dbj|BAA03770.2| (D16251) ORF4; ORF4 has several potential initia... 80 4e-14
sp|P39642|YWFF_BACSU HYPOTHETICAL 43.4 KD PROTEIN IN ROCC-PTA IN... 80 5e-14
pir||C83068 probable MFS transporter PA4622 [imported] - Pseudom... 80 5e-14
emb|CAB71252.1| (AL138598) putative integral membrane efflux pro... 80 6e-14
dbj|BAA36682.1| (AB016427) transmembrane protein [Bacillus liche... 79 8e-14
pir||A82737 probable transport protein XF0993 [similarity] - Xyl... 79 1e-13
pir||T36090 probable integral membrane efflux protein - Streptom... 78 2e-13
pir||A81752 conserved hypothetical protein TC0009 [imported] - C... 78 2e-13
pir||A83308 probable MFS transporter PA2701 [imported] - Pseudom... 77 3e-13
emb|CAB92212.1| (AL356592) putative transmembrane transport prot... 76 7e-13
gb|AAD45543.1|U70376_8 (U70376) SpcT [Streptomyces flavopersicus] 76 9e-13
gi|10954847 Hypothetical gene [Agrobacterium tumefaciens] >gi|64... 73 5e-12
gb|AAD50454.1|AF170704_4 (AF170704) SpcT [Streptomyces spectabilis] 73 6e-12
pir||F72041 efflux protein - Chlamydophila pneumoniae (strain CW... 73 8e-12
pir||E81624 conserved hypothetical protein CP0009 [imported] - C... 73 8e-12
gb|AAF63340.1|AF244574_3 (AF244574) export protein [Streptomyces... 73 8e-12
emb|CAB62691.1| (AL133422) putative transmembrane efflux protein... 72 1e-11
sp|P39843|BMR2_BACSU MULTIDRUG RESISTANCE PROTEIN 2 (MULTIDRUG-E... 71 2e-11
pir||D71112 hypothetical protein PH0667 - Pyrococcus horikoshii ... 69 7e-11
>pir||B75087 multidrug resistance protein (multidrug-ef flux transporter)
PAB0724 - Pyrococcus abyssi (strain Orsay)
>gi|5458511|emb|CAB49999.1| (AJ248286) MULTIDRUG
RESISTANCE PROTEIN (MULTIDRUG-EF FLUX TRANSPORTER)
[Pyrococcus abyssi]
Length = 418
Score = 817 bits (2087), Expect = 0.0
Identities = 418/418 (100%), Positives = 418/418 (100%)
Query: 1 MNRNFWLFVAGRFISQLGWAIQEVALPLYVLDVTHSAKIMTLFVLADLIPSIITTPIAGV 60
MNRNFWLFVAGRFISQLGWAIQEVALPLYVLDVTHSAKIMTLFVLADLIPSIITTPIAGV
Sbjct: 1 MNRNFWLFVAGRFISQLGWAIQEVALPLYVLDVTHSAKIMTLFVLADLIPSIITTPIAGV 60
Query: 61 FGDRYDRKKIMVGFDLIRGVLLFLVIAFNFLTIRCLLVVQVIMAIMNAFFSAGTGAMYPD 120
FGDRYDRKKIMVGFDLIRGVLLFLVIAFNFLTIRCLLVVQVIMAIMNAFFSAGTGAMYPD
Sbjct: 61 FGDRYDRKKIMVGFDLIRGVLLFLVIAFNFLTIRCLLVVQVIMAIMNAFFSAGTGAMYPD 120
Query: 121 LVKPEELERANSIVMSASIISRLVGPAIGGFVYGFGGIKLAILMNAISFFGSGLFEIFIK 180
LVKPEELERANSIVMSASIISRLVGPAIGGFVYGFGGIKLAILMNAISFFGSGLFEIFIK
Sbjct: 121 LVKPEELERANSIVMSASIISRLVGPAIGGFVYGFGGIKLAILMNAISFFGSGLFEIFIK 180
Query: 181 YEWKTRNIEGFSDFVRDIKEGLKFIMSNSFISTLIGLVILLNALGAPFASIIYPYAMREI 240
YEWKTRNIEGFSDFVRDIKEGLKFIMSNSFISTLIGLVILLNALGAPFASIIYPYAMREI
Sbjct: 181 YEWKTRNIEGFSDFVRDIKEGLKFIMSNSFISTLIGLVILLNALGAPFASIIYPYAMREI 240
Query: 241 LKFSSQQFGLVESAFMLGALIGNLIVGAFLGAKAGRYIFRLFLVNGAVELIFILIISPFL 300
LKFSSQQFGLVESAFMLGALIGNLIVGAFLGAKAGRYIFRLFLVNGAVELIFILIISPFL
Sbjct: 241 LKFSSQQFGLVESAFMLGALIGNLIVGAFLGAKAGRYIFRLFLVNGAVELIFILIISPFL 300
Query: 301 ALPRNSAFMLLLVLGATMGMAGAMINVPLASKLQRAVPSEIRGRVFSTMEMLARIANPLS 360
ALPRNSAFMLLLVLGATMGMAGAMINVPLASKLQRAVPSEIRGRVFSTMEMLARIANPLS
Sbjct: 301 ALPRNSAFMLLLVLGATMGMAGAMINVPLASKLQRAVPSEIRGRVFSTMEMLARIANPLS 360
Query: 361 LVVVGPLVDTIGAWKTASFLWLGSGVVILYYWIFKGKELTSEEESKLVENFPGVPPED 418
LVVVGPLVDTIGAWKTASFLWLGSGVVILYYWIFKGKELTSEEESKLVENFPGVPPED
Sbjct: 361 LVVVGPLVDTIGAWKTASFLWLGSGVVILYYWIFKGKELTSEEESKLVENFPGVPPED 418
>pir||D75093 macrolide-efflux determinant related PAB0754 - Pyrococcus abyssi
(strain Orsay) >gi|5458561|emb|CAB50049.1| (AJ248286)
MACROLIDE-EFFLUX DETERMINANT related [Pyrococcus abyssi]
Length = 398
Score = 374 bits (949), Expect = e-102
Identities = 191/395 (48%), Positives = 272/395 (68%), Gaps = 10/395 (2%)
Query: 1 MNRNFWLFVAGRFISQLGWAIQEVALPLYVLDVTHSAKIMTLFVLADLIPSIITTPIAGV 60
+ R+FWLF GR+IS GWAIQ+VA+PLYVLD T S +M+LFV+A+LIP I+ PIAGV
Sbjct: 4 LGRDFWLFAVGRWISIAGWAIQDVAIPLYVLDKTGSGTMMSLFVMAELIPRILVNPIAGV 63
Query: 61 FGDRYDRKKIMVGFDLIRGVLLFLVIAFNFLTIRCLLVVQVIMAIMNAFFSAGTGAMYPD 120
GDRY+RK +MVGFDLIRGVLLF V+ FN L + LLV+QVIM+I +FF+AGT M+PD
Sbjct: 64 IGDRYNRKYLMVGFDLIRGVLLFFVLFFNLLELEQLLVIQVIMSIFGSFFAAGTSGMFPD 123
Query: 121 LVKPEELERANSIVMSASIISRLVGPAIGGFVYGFGGIKLAILMNAISFFGSGLFEIFIK 180
LV + L +ANSI+ + + +V P IGG +YG GGIK AI +NAISFFGSGLFEI I+
Sbjct: 124 LVPKDRLMQANSILQMGTQVINIVSPVIGGAIYGLGGIKAAIFINAISFFGSGLFEISIR 183
Query: 181 YEWKTRNIEGFSDFVRDIKEGLKFIMSNSFISTLIGLVILLNALGAPFASIIYPYAMREI 240
YEWK + E F+ +R+ +G+K I S+ + L L I+LNAL +P +I++PY +R +
Sbjct: 184 YEWKGKG-EKFA-ILREFLDGIKLIKSSKPLLILGSLSIILNALFSPLFAIVFPYIVRVV 241
Query: 241 LKFSSQQFGLVESAFMLGALIGNLIVGAFLGAKAGRYIFRLFLVNGAVELIFILII--SP 298
L+ SS QFG V++A LG L+GNLI+ + L AG++ + L ++ +FILI+ +P
Sbjct: 242 LRLSSIQFGSVQTALTLGMLLGNLIIASILKNSAGKHFMKAIL----IQELFILIVPFTP 297
Query: 299 FLALPRNSAFMLLLVLGATMGMAGAMINVPLASKLQRAVPSEIRGRVFSTMEMLARIANP 358
L+ PRN ++++L +G ++N+P+ +KLQ VP E R R FST+E L+ A P
Sbjct: 298 KLSYPRN--YLVILTSAFAIGFFNVLVNIPIMTKLQTIVPREYRARFFSTLETLSMGATP 355
Query: 359 LSLVVVGPLVDTIGAWKTASFLWLGSGVVILYYWI 393
L +++VGP +D +G + + L + + +YYW+
Sbjct: 356 LGMIIVGPTIDKLGYFSVSITLTIVGIAISVYYWL 390
>pir||C71050 probable macrolide-efflux determinant - Pyrococcus horikoshii
>gi|3257514|dbj|BAA30197.1| (AP000005) 403aa long
hypothetical macrolide-efflux determinant [Pyrococcus
horikoshii]
Length = 403
Score = 371 bits (943), Expect = e-102
Identities = 188/404 (46%), Positives = 271/404 (66%), Gaps = 9/404 (2%)
Query: 1 MNRNFWLFVAGRFISQLGWAIQEVALPLYVLDVTHSAKIMTLFVLADLIPSIITTPIAGV 60
+ R+FWLF GR+IS GW IQ+VA+PLYVLD T S +M+ FV+A+LIP II P+AGV
Sbjct: 3 LGRDFWLFSVGRWISTAGWTIQDVAVPLYVLDKTGSGTMMSAFVMAELIPRIILNPLAGV 62
Query: 61 FGDRYDRKKIMVGFDLIRGVLLFLVIAFNFLTIRCLLVVQVIMAIMNAFFSAGTGAMYPD 120
GDRY+RK +MVGFDL RGVLLFL+IA N L +R LL+VQVIM+ M +FFSAGT AM+PD
Sbjct: 63 IGDRYNRKHLMVGFDLARGVLLFLIIALNMLELRELLIVQVIMSAMGSFFSAGTSAMFPD 122
Query: 121 LVKPEELERANSIVMSASIISRLVGPAIGGFVYGFGGIKLAILMNAISFFGSGLFEIFIK 180
LV EEL +ANSI+ + + ++ PA+GG +YG GGI+ AIL+NAISFFGSGLFEI I+
Sbjct: 123 LVPKEELMQANSILQMGTQVINVISPALGGLIYGLGGIRAAILVNAISFFGSGLFEILIR 182
Query: 181 YEWKTRNIE-GFSDFVRDIKEGLKFIMSNSFISTLIGLVILLNALGAPFASIIYPYAMRE 239
YEW+ + + + V + E L I ++ ++ +I ++LNAL P ++++PY +R
Sbjct: 183 YEWRRKAGKLTITKVVEEFLEALNLIKNSQMLTVIISFSVILNALLNPLFAVVFPYMVRV 242
Query: 240 ILKFSSQQFGLVESAFMLGALIGNLIVGAFLGAKAGRYIFRLFLVNGAVELIFILII--S 297
++K S+ QFG V+++ LG L+GNLI+ L A ++IF+ A++ F+L+I +
Sbjct: 243 VVKLSAFQFGTVQTSLTLGMLVGNLIIAGILRESATKHIFKAL----AIQEFFLLMIPFT 298
Query: 298 PFLALPRNSAFMLLLVLGATMGMAGAMINVPLASKLQRAVPSEIRGRVFSTMEMLARIAN 357
P L P N + +L + +G+ ++N+P+ +KLQR VP E R R+FST+E L A
Sbjct: 299 PRLYYPEN--YFAILTIVFIIGVFNVLVNIPILTKLQREVPEEYRARIFSTLETLVMSAT 356
Query: 358 PLSLVVVGPLVDTIGAWKTASFLWLGSGVVILYYWIFKGKELTS 401
P+ + ++GP VD +G + L L ++ LYYW+ K L S
Sbjct: 357 PVGMALIGPAVDKLGYLRVTLSLTLIGILITLYYWVRYSKLLVS 400
>pir||D72388 hypothetical protein TM0342 - Thermotoga maritima (strain MSB8)
>gi|4980843|gb|AAD35428.1|AE001715_4 (AE001715)
permease, putative [Thermotoga maritima]
Length = 413
Score = 290 bits (735), Expect = 2e-77
Identities = 162/407 (39%), Positives = 243/407 (58%), Gaps = 14/407 (3%)
Query: 3 RNFWLFVAGRFISQLGWAIQEVALPLYVLDVTHSAKIMTLFVLADLIPSIITTPIAGVFG 62
RNF+L GRF+S LG ++Q VA+PL+VLD+THS + L +A ++P I+ TPIAG+ G
Sbjct: 9 RNFFLLALGRFVSILGSSVQAVAIPLFVLDLTHSGSAVALMTVAYMVPRILFTPIAGIVG 68
Query: 63 DRYDRKKIMVGFDLIRGVLL--FLVIAF-NFLTIRCLLVVQVIMAIMNAFFSAGTGAMYP 119
DR DRK +MV D +RG L+ ++AF N +T+ L V Q+ MAIM+ F TGAM+P
Sbjct: 69 DRGDRKFLMVSMDFLRGFLICFLALLAFRNSITLPVLYVSQIAMAIMDNLFDIPTGAMFP 128
Query: 120 DLVKPEELERANSIVMSASIISRLVGPAIGGFVYGFGGIKLAILMNAISFFGSGLFEIFI 179
D+V + L RANSI+ I +++GPA+GG +YGF GI + L+N +SF S + EIFI
Sbjct: 129 DIVPQDFLMRANSIMGMVRIFPQILGPALGGVIYGFYGIAIVFLVNGVSFVLSAISEIFI 188
Query: 180 KYEWKT-RNIEGFSDFVRDIKEGLKFIMSNSFISTLIGLVILLNALGAPFASIIYPYAMR 238
Y K + FS + D+KEG FI ++ I T++ + LN L +P ++YPY +R
Sbjct: 189 VYSRKVEKKPAKFSQILEDLKEGFLFIWNHELIRTILIFALFLNLLISPLFMVVYPYTIR 248
Query: 239 EILKFSSQQFGLVESAFMLGALIGNLIVGAFLGAKAGRYIFRLFLVNGAVELIFI-LIIS 297
E++KFS+Q+FG +E++F LGAL+GN ++ ++L K ++ + + ++F+ ++
Sbjct: 249 EVMKFSAQEFGFLETSFTLGALLGNFLIASYLSKKNMWKAMKISIFLFELPIVFLGFLVM 308
Query: 298 PFLALPRNSAFMLLLVLGATMGMAGAMINVPLASKLQRAVPSEIRGRVFSTMEMLARIAN 357
P +L R F L + MG +INVPL + Q+ PS IR R FS + ++A
Sbjct: 309 PDFSLNRLVLFSLFFITFLIMGFLNPIINVPLDTAFQKMTPSHIRARAFSFLILVANGVT 368
Query: 358 PLSLVVVGPLVDTIGAWKTASFLWLGSG-----VVILYYWIFKGKEL 399
PL V+ G LVD + FL+ G V +L +GKEL
Sbjct: 369 PLGSVLYGYLVDRV----PVHFLYYVVGALSFLVAVLLLVALRGKEL 411
>pir||H72265 hypothetical protein TM1336 - Thermotoga maritima (strain MSB8)
>gi|4981896|gb|AAD36408.1|AE001788_3 (AE001788)
permease, putative [Thermotoga maritima]
Length = 390
Score = 180 bits (453), Expect = 2e-44
Identities = 124/396 (31%), Positives = 212/396 (53%), Gaps = 21/396 (5%)
Query: 1 MNRNFWLFVAGRFISQLGWAIQEVALPLYVLDVTHSAKIMTLFVLADLIPSIITTPIAGV 60
MNRN LF +G F+S +G I +VAL ++ T S++ + LF+++ +P+II +P AG
Sbjct: 1 MNRNLLLFASGSFVSLIGTRIYQVALAWWLYSKTGSSEYVGLFMISSFLPAIIVSPFAGT 60
Query: 61 FGDRYDRKKIMVGFDLIRGVL---LFLVIAFNFLTIRCLLVVQVIMAIMNAFFSAGTGAM 117
DR+ R+ +MV D++RGVL LFL+ F+ LT+ LL+V V++++ ++FF+ ++
Sbjct: 61 VVDRHSRRNMMVVMDILRGVLFMYLFLMEYFSELTMALLLIVTVLVSVFDSFFNPAVDSL 120
Query: 118 YPDLVKPEELERANSIVMSASIISRLVGPAIGGFVYGFGGIKLAILMNAISFFGSGLFEI 177
PDLV+ E L RANS+ +S+++GPA+G + G+ IL+N++SF SG+FE+
Sbjct: 121 LPDLVRKENLVRANSLYRLLKNLSKILGPALGSLLLKVVGLAGVILINSLSFLISGIFEM 180
Query: 178 FIKYEWK-TRNIEGFSDFVRDIKEGLKFIMSNSFISTLIGLVILLNALGAPFASIIYPYA 236
FIK E K + + + +DIK L +I S FI I ++ ++N ++ P
Sbjct: 181 FIKVEEKHLKKVSKERNMWQDIKSALLYIRSVRFILVTILVIAIMNFFTGSM-HVLLPEH 239
Query: 237 MREILKFSSQQFGLVESAFMLGALIGNLIVGAFLGAKAGRYIFRLFLVN-GAVELIFILI 295
+ ++ K S +G + S G LI ++ A + +A L LV G +F +
Sbjct: 240 VSKLGK-SEWVYGTLMSMLSFGGLIVTFLM-ATIRTRASVKTLGLNLVGYGLAVFVFAM- 296
Query: 296 ISPFLALPRNSAFMLLLVLGATMGMAGAMINVPLASKLQRAVPSEIRGRVFSTMEMLARI 355
L+ + +G+ + N+ + + LQ A+P E+RG++FS + ++
Sbjct: 297 ---------TGNHWLMFAMYFLIGIFQTLFNINVITLLQLAIPEEMRGKIFSLISAVSFS 347
Query: 356 ANPLSLVVVGPL---VDTIGAWKTASFLWLGSGVVI 388
P+S G L V T + T S + GV+I
Sbjct: 348 LLPVSYGFFGFLSSYVATAHIFITTSMALIAGGVLI 383
>gb|AAC44785.1| (U70055) macrolide-efflux protein [Streptococcus pyogenes]
>gi|10119927|gb|AAG12998.1|AF227520_4 (AF227520)
macrolide-efflux protein A [Streptococcus pneumoniae]
Length = 405
Score = 131 bits (327), Expect = 1e-29
Identities = 101/390 (25%), Positives = 185/390 (46%), Gaps = 18/390 (4%)
Query: 5 FWLFVAGRFISQLGWAIQEVALPLYVLDVTHSAKIMTLFVLADLIPSIITTPIAGVFGDR 64
F+ AG+ +S + AI ++A+ Y+ + T SA ++++ L +P + P GV DR
Sbjct: 11 FYTIWAGQAVSLITSAILQMAIIFYLTEKTGSAMVLSMASLLGFLPYAVFGPAIGVLVDR 70
Query: 65 YDRKKIMVGFDLI---RGVLLFLVIAFNFLTIRCLLVVQVIMAIMNAFFSAGTGAMYPDL 121
+DRKKIM+G DLI G +L +V + L + +++V I +I AF + A+ P L
Sbjct: 71 HDRKKIMIGADLIIAAAGSVLTIVAFYMELPVWMVMIVLFIRSIGTAFHTPALNAVTPLL 130
Query: 122 VKPEELERANSIVMSASIISRLVGPAIGGFVYGFGGIKLAILMNAISFFGSGLFEIFIKY 181
V E+L + S IS +V PA+ +Y + I ++ + + + ++
Sbjct: 131 VPEEQLTKCAGYSQSLQSISYIVSPAVAALLYSVWELNAIIAIDVLGAVIASITVAIVRI 190
Query: 182 EWKTRNIEGFS-DFVRDIKEGLKFIMSNSFISTLIGLVILLNALGAPFASIIYPYAMREI 240
++ +F+R+++EG+ + N + L+ + L + P + ++P +
Sbjct: 191 PKLGDRVQSLDPNFIREMQEGMAVLRQNKGLFALLLVGTLYMFVYMPI-NALFPLISMDY 249
Query: 241 LKFSSQQFGLVESAFMLGALIGNLIVGAFLGAKAGRYIFRLFLVNGAVELIFI-LIISPF 299
+ + E +F G LIG L++G F G Y R+ L+ ++ ++ I L IS
Sbjct: 250 FNGTPVHISITEISFASGMLIGGLLLGLF-----GNYQKRILLITASIFMMGISLTISGL 304
Query: 300 LALPRNSAFMLLLVLGATMGMAGAMINVPLASKLQRAVPSEIRGRVFSTMEMLARIANPL 359
L S F + +V A MG++ + + Q + E GRVFS + +A P+
Sbjct: 305 LP---QSGFFIFVVCCAIMGLSVPFYSGVQTALFQEKIKPEYLGRVFSLTGSIMSLAMPI 361
Query: 360 SLVVVGPLVDTIGAWKTASFLWLGSGVVIL 389
L++ D IG + +L SG +I+
Sbjct: 362 GLILSALFADRIG----VNHWFLLSGTLII 387
>dbj|BAA89223.1| (AB011259) macrolide-efflux pump [Streptococcus pneumoniae]
Length = 402
Score = 131 bits (326), Expect = 2e-29
Identities = 103/393 (26%), Positives = 187/393 (47%), Gaps = 20/393 (5%)
Query: 3 RNFWLFVAGRFISQLGWAIQEVALPLYVLDVTHSAKIMTLFVLADLIPSIITTPIAGVFG 62
R F+ AG+ +S + AI ++A+ Y+ + T SA ++++ L +P I P GV
Sbjct: 9 RKFYAIWAGQAVSLITSAILQMAIIFYLTEKTGSAMVLSMASLVGFLPYAILGPAIGVLV 68
Query: 63 DRYDRKKIMVGFDLI---RGVLLFLVIAFNFLTIRCLLVVQVIMAIMNAFFSAGTGAMYP 119
DR+DRKKIM+G DLI G +L +V L + +++V I +I AF + A+ P
Sbjct: 69 DRHDRKKIMIGADLIIAAAGAVLAIVAFCMELPVWMIMIVLFIRSIGTAFHTPALNAVTP 128
Query: 120 DLVKPEELERANSIVMSASIISRLVGPAIGGFVYGFGGIKLAILMNAISFFGSGLFEIFI 179
LV E+L + S IS +V PA+ +Y + I ++ + + + +
Sbjct: 129 LLVPEEQLTKCAGYSQSLQSISYIVSPAVAALLYSVWDLNAIIAIDVLGAVIASITVAIV 188
Query: 180 KYEWKTRNIEGFS-DFVRDIKEGLKFIMSNSFISTLIGLVILLNALGAPFASIIYPYAMR 238
+ ++ +F+R++KEG+ + N + L+ L L + P + ++P
Sbjct: 189 RIPKLGNQVQSLEPNFIREMKEGVVVLRQNKGLFALLLLGTLYTFVYMPI-NALFPLISM 247
Query: 239 EILKFSSQQFGLVESAFMLGALIGNLIVGAFLGAKAGRYIFRLFLVNGAVELIFILIISP 298
E + + E +F G L G L++G + G + + L+ + FI+ S
Sbjct: 248 EHFNGTPVHISITEISFAFGMLAGGLLLG-----RLGGFEKHVLLITSS---FFIMGTSL 299
Query: 299 FLA--LPRNSAFMLLLVLGATMGMAGAMINVPLASKLQRAVPSEIRGRVFSTMEMLARIA 356
++ LP N F++ +V A MG++ + + Q + E GRVFS + + +A
Sbjct: 300 AVSGILPPN-GFVIFVVCCAIMGLSVPFYSGVQTALFQEKIKPEYLGRVFSLIGSIMSLA 358
Query: 357 NPLSLVVVGPLVDTIGAWKTASFLWLGSGVVIL 389
P+ L++ G D IG + +L SG++I+
Sbjct: 359 MPIGLILSGFFADKIG----VNHWFLLSGILII 387
>gb|AAB41436.1| (U83667) macrolide-efflux determinant [Streptococcus pneumoniae]
Length = 405
Score = 131 bits (326), Expect = 2e-29
Identities = 103/393 (26%), Positives = 187/393 (47%), Gaps = 20/393 (5%)
Query: 3 RNFWLFVAGRFISQLGWAIQEVALPLYVLDVTHSAKIMTLFVLADLIPSIITTPIAGVFG 62
R F+ AG+ +S + AI ++A+ Y+ + T SA ++++ L +P I P GV
Sbjct: 9 RKFYAIWAGQAVSLITSAILQMAIIFYLTEKTGSAMVLSMASLVGFLPYAILGPAIGVLV 68
Query: 63 DRYDRKKIMVGFDLI---RGVLLFLVIAFNFLTIRCLLVVQVIMAIMNAFFSAGTGAMYP 119
DR+DRKKIM+G DLI G +L +V L + +++V I +I AF + A+ P
Sbjct: 69 DRHDRKKIMIGADLIIAAAGAVLAIVAFCMELPVWMIMIVLFIRSIGTAFHTPALNAVTP 128
Query: 120 DLVKPEELERANSIVMSASIISRLVGPAIGGFVYGFGGIKLAILMNAISFFGSGLFEIFI 179
LV E+L + S IS +V PA+ +Y + I ++ + + + +
Sbjct: 129 LLVPEEQLTKCAGYSQSLQSISYIVSPAVAALLYSVWDLNAIIAIDVLGAVIASITVAIV 188
Query: 180 KYEWKTRNIEGFS-DFVRDIKEGLKFIMSNSFISTLIGLVILLNALGAPFASIIYPYAMR 238
+ ++ +F+R++KEG+ + N + L+ L L + P + ++P
Sbjct: 189 RIPKLGNQVQSLEPNFIREMKEGVVVLRQNKGLFALLLLGTLYTFVYMPI-NALFPLISM 247
Query: 239 EILKFSSQQFGLVESAFMLGALIGNLIVGAFLGAKAGRYIFRLFLVNGAVELIFILIISP 298
E + + E +F G L G L++G + G + + L+ + FI+ S
Sbjct: 248 EHFNGTPVHISITEISFAFGMLAGGLLLG-----RLGGFEKHVLLITSS---FFIMGTSL 299
Query: 299 FLA--LPRNSAFMLLLVLGATMGMAGAMINVPLASKLQRAVPSEIRGRVFSTMEMLARIA 356
++ LP N F++ +V A MG++ + + Q + E GRVFS + + +A
Sbjct: 300 AVSGILPPN-GFVIFVVCCAIMGLSVPFYSGVQTALFQEKIKPEYLGRVFSLIGSIMSLA 358
Query: 357 NPLSLVVVGPLVDTIGAWKTASFLWLGSGVVIL 389
P+ L++ G D IG + +L SG++I+
Sbjct: 359 MPIGLILSGFFADKIG----VNHWFLLSGILII 387
>emb|CAA10866.1| (AJ222587) YkuC protein [Bacillus subtilis]
Length = 430
Score = 109 bits (270), Expect = 6e-23
Identities = 101/407 (24%), Positives = 173/407 (41%), Gaps = 28/407 (6%)
Query: 2 NRNFWLFVAGRFISQLGWAIQEVALPLYVLD-VTHSAKIMTLFVLADLIPSIITTPIAGV 60
NRNF SQ+G + +A ++LD + TL L +P+I I GV
Sbjct: 6 NRNFVRLFFAALASQMGTTVGNMAFAFFLLDRFSSQPSYTTLAELMYSLPTIFVFLIVGV 65
Query: 61 FGDRYDRKKIMVGFDLIRG----VLLFLVIAFNFLTIRCLLVVQVIMAIMNAFFSAGTGA 116
DR+DRKK+ D IR VL F + N + C+L ++ + + FF +
Sbjct: 66 VADRFDRKKVAENCDWIRAGLTVVLFFTLFTGNIPLVFCILFIR---SAVTKFFFPAENS 122
Query: 117 MYPDLVKPEELERANSIVMSASIISRLVGPAIGGFVYGFGGIKLAILMNAISFFGSGLFE 176
+ ++ E +A + I + G IG F+Y GI+ AI+++ +SF SGL
Sbjct: 123 LVQAILPKEHYAKAAGLNQMLFSIFMVFGVGIGAFMYNTIGIEGAIILDFVSFIISGLLI 182
Query: 177 IFIKYEWKTRNIEG--------FSDFVRDIKEGLKFIMSNSFISTLIGLVILLNALGAPF 228
+ + R G D + D +EG+ +I+ N +++LI + + F
Sbjct: 183 RSCRIPKEARQPNGAFSWRKTSVKDSINDFREGILYILKNKLLASLIFGFFIFGFVNGGF 242
Query: 229 ASIIYPYAMREILKFSSQQFGLVESAFMLG-ALIGNLIVGAFLGAKAGRYIFRLFLVNGA 287
A ++ + M+ L ++ LG L+ ++G + K + + A
Sbjct: 243 A-VLPMFTMKYGLAPDRYEWHTSVFTIALGFGLLAGSVIGTLISKKVKPHFLMSIPIFIA 301
Query: 288 VELIFILIISPFLALPRNSAFMLLLVLGATMGMAGAMINVPLASKLQRAVPSEIRGRVFS 347
LIF+L + L + +AF L GM IN+ + + + V ++ GRV
Sbjct: 302 GLLIFVLGYTNILWVYYAAAFAL--------GMCIGPINIAIGGWMPKIVHPKLMGRVSG 353
Query: 348 TMEMLARIANPLSLVVVGPLVDTIGAWKTASFLWLGSGVVILYYWIF 394
+ A L+L +V L + +L+ G GV+IL +IF
Sbjct: 354 MQDPFMMFAQSLTLGLVALLFPKFVS--NIDYLYYGMGVIILLVFIF 398
>pir||H69864 macrolide-efflux protein homolog ykuC - Bacillus subtilis
>gi|2633774|emb|CAB13276.1| (Z99111) similar to
macrolide-efflux protein [Bacillus subtilis]
Length = 430
Score = 108 bits (268), Expect = 1e-22
Identities = 101/407 (24%), Positives = 173/407 (41%), Gaps = 28/407 (6%)
Query: 2 NRNFWLFVAGRFISQLGWAIQEVALPLYVLD-VTHSAKIMTLFVLADLIPSIITTPIAGV 60
NRNF SQ+G + +A ++LD + TL L +P+I I GV
Sbjct: 6 NRNFVRLFFAALASQMGTTVGNMAFAFFLLDRFSSQPSYTTLAELMYSLPTIFVFLIVGV 65
Query: 61 FGDRYDRKKIMVGFDLIRG----VLLFLVIAFNFLTIRCLLVVQVIMAIMNAFFSAGTGA 116
DR+DRKK+ D IR VL F + N + C+L ++ + + FF +
Sbjct: 66 VPDRFDRKKVAENCDWIRAGLTVVLFFTLFTGNIPLVFCILFIR---SAVTKFFFPAENS 122
Query: 117 MYPDLVKPEELERANSIVMSASIISRLVGPAIGGFVYGFGGIKLAILMNAISFFGSGLFE 176
+ ++ E +A + I + G IG F+Y GI+ AI+++ +SF SGL
Sbjct: 123 LVQAILPKEHYAKAAGLNQMLFSIFMVFGVGIGAFMYNTIGIEGAIILDFVSFIISGLLI 182
Query: 177 IFIKYEWKTRNIEG--------FSDFVRDIKEGLKFIMSNSFISTLIGLVILLNALGAPF 228
+ + R G D + D +EG+ +I+ N +++LI + + F
Sbjct: 183 RSCRIPKEARQPNGPFSWRKTSVKDSINDFREGILYILKNKLLASLIFGFFIFGFVNGGF 242
Query: 229 ASIIYPYAMREILKFSSQQFGLVESAFMLG-ALIGNLIVGAFLGAKAGRYIFRLFLVNGA 287
A ++ + M+ L ++ LG L+ ++G + K + + A
Sbjct: 243 A-VLPMFTMKYGLAPDRYEWHTSVFTIALGFGLLAGSVIGTLISKKVKPHFLMSIPIFIA 301
Query: 288 VELIFILIISPFLALPRNSAFMLLLVLGATMGMAGAMINVPLASKLQRAVPSEIRGRVFS 347
LIF+L + L + +AF L GM IN+ + + + V ++ GRV
Sbjct: 302 GLLIFVLGYTNILWVYYAAAFAL--------GMCIGPINIAIGGWMPKIVHPKLMGRVSG 353
Query: 348 TMEMLARIANPLSLVVVGPLVDTIGAWKTASFLWLGSGVVILYYWIF 394
+ A L+L +V L + +L+ G GV+IL +IF
Sbjct: 354 MQDPFMMFAQSLTLGLVALLFPKFVS--NIDYLYYGMGVIILLVFIF 398
>dbj|BAB05758.1| (AP001514) unknown conserved protein in others [Bacillus
halodurans]
Length = 418
Score = 107 bits (265), Expect = 2e-22
Identities = 99/391 (25%), Positives = 175/391 (44%), Gaps = 21/391 (5%)
Query: 2 NRNFWLFVAGRFISQLGWAIQEVALPLYVLDVTHSAKIMTLFVLADLIPSIITTPIAGVF 61
N++F +V + +S + + + + V + S I+ L +L IP II +AGV
Sbjct: 10 NKSFIFWVLAQIVSPIAESFAALLITWTVWQQSSSTGILALTLLLAAIPQIIFGVVAGVA 69
Query: 62 GDRYDRKKIMVGFDLIRGVLLFL--VIAFN-FLTIRCLLVVQVIMAIMNAFFSAGTGAMY 118
D ++RK I++ ++IR V++ L ++AF+ L ++ + + F A
Sbjct: 70 TDWFNRKHIVMLCNVIRAVIMILLGMLAFSQLLNELVFMLASFSLGFLRLFAMTAYRAAM 129
Query: 119 PDLVKPEELERANSIVMSASIISRLVGPAIGGFVYGFGGIKLAILMNAISFFGSGLFEIF 178
P +V ++L +AN+I S + L+GP GF ++MNAI F S +
Sbjct: 130 PGIVHSDQLMKANAITNSCRMAFWLIGPVFAGFCLTLLNTGQIMIMNAILFIVSVF--LL 187
Query: 179 IKYEWKTRNIEGFSDFV-RDIKEGLKFIMSNSFISTLIGLVILLNALGAPFASIIYPYAM 237
I K +E + +DI GL+ + + I +++ G A +
Sbjct: 188 IPVHIKQAKVEQHQKHMFKDIAVGLRLVTQDRLIYSVLMTFAAFTCFGRGIAHLGNLMVS 247
Query: 238 REILKFSSQQFGLVESAFMLGALIGNLIVGAFLGAKAGRYIFRLFLVNGAVELIFILIIS 297
EI S FG++ SA G LI L++ + R + +L+ G V
Sbjct: 248 NEI-GLDSSGFGILSSADGFGYLIAGLLLARLSIKNSFRTMMLAWLLGGIV--------- 297
Query: 298 PFLALPRNSAFMLLLVLGATMGMAGAMINVPLASKLQRAVPSEIRGRVFSTMEMLARIAN 357
FL +P +SA L +L +GM+ ++VPL + +Q+ V + G+VF + I
Sbjct: 298 -FLFMPFSSALWLPFILLFIVGMSQPFVDVPLVTMIQKRVADQHLGKVFGFHTVTIWIGE 356
Query: 358 PLSLVVVGPLVDTIGAWKTASFLWLGSGVVI 388
L+ G L GA+ T + ++ SGV++
Sbjct: 357 FLAYATFGYL---FGAY-TPTMIYALSGVIV 383
>dbj|BAB07605.1| (AP001520) multidrug-efflux transporter [Bacillus halodurans]
Length = 411
Score = 107 bits (264), Expect = 3e-22
Identities = 93/372 (25%), Positives = 167/372 (44%), Gaps = 18/372 (4%)
Query: 3 RNFWLFVAGRFISQLGWAIQEVALPLYVLDVTHSAKIMTLFVLADLIPSIITTPIAGVFG 62
R F + + +S LG + + +T S M+ +A +IP ++T +AG +
Sbjct: 8 RPFVVLWIAQSVSALGGTFTTFTVSWLMYQLTDSLVAMSGVWIAFMIPKLLTNLVAGPYL 67
Query: 63 DRYDRKKIMVGFDLIRGVLLF---LVIAFNFLTIRCLLVVQVIMAIMNAFFSAGTGAMYP 119
DR+ K +MV + IR V F +++ + LT L++ V+ I F A
Sbjct: 68 DRFQYKVVMVASEWIRAVAFFVPTVLLVGDMLTAPVLIMAAVLTGIAEPLFRPAGMAYVA 127
Query: 120 DLVKPEELERANSIVMSASIISRLVGPAIGGFVYGFGGIKLAILMNAISFFGSGLFEIFI 179
++ + L+R NSI+ I L+GPA+GG + G ++ I+ SG + +
Sbjct: 128 HILPEKHLQRGNSILEGTMQIVMLIGPALGGGLIVLVGPLPLLVFIVIALTVSGFLLLML 187
Query: 180 KYEWKTRNIEGFSDFVRDIKEGLKFIMSNSFISTLIGLVILLNALGAPFASIIYPYAMRE 239
+ + + S ++ KEG+ F + ++ L++++N + PY + E
Sbjct: 188 DRVHRAKTNDRAS-WLTMFKEGMSFYKVYPVLFSVGLLMMMINFSSGAALPMFLPYVL-E 245
Query: 240 ILKFSSQQFGLVESAFMLGALIGNLIVGAFLGAKAGRYIFRLFLVNGAVELIFILIISPF 299
L + Q+GL S + LG ++G+ + G + K R + ++ L +S F
Sbjct: 246 HLHGTEFQYGLFMSVYSLGMVLGSFLCGLYPPPKNLRRV-----------MLGYLTVSSF 294
Query: 300 LALPRNSAFMLLLVLG-ATM-GMAGAMINVPLASKLQRAVPSEIRGRVFSTMEMLARIAN 357
L + + + +G ATM G + + QR VP +RGRVF+ +LA+ A
Sbjct: 295 LMMALGFITSIWIAIGIATMQGFFAMAFTINNTTFYQRRVPEHLRGRVFTVRALLAQSAI 354
Query: 358 PLSLVVVGPLVD 369
PL V G L +
Sbjct: 355 PLGAGVGGLLAE 366
>emb|CAA63510.1| (X92946) macrolide efflux protein [Lactococcus lactis]
Length = 418
Score = 103 bits (255), Expect = 3e-21
Identities = 98/378 (25%), Positives = 170/378 (44%), Gaps = 19/378 (5%)
Query: 3 RNFWLFVAGRFISQLGWAIQEVALPLYVLDVTHSAKIMTLFVLADLIPSIITTPIAGVFG 62
+NF+LF+ G+ ++ + I + A+ Y+ T ++ + L ++P + +P G F
Sbjct: 11 KNFYLFLIGQLLTGVTSMIVQYAIIWYLTLETGEESVLAIATLVGMLPMALLSPFVGPFI 70
Query: 63 DRYDRKKIMVGFDLIRGVL---LFLVIAFNFLTIRCLLVVQV-IMAIMNAFFSAGTGAMY 118
DR ++K +++ +D + V+ LF+ N + ++ V + I A+ ++
Sbjct: 71 DRINKKFLLISYDAVVAVIALGLFIYGINNDVYPLWMVFVTIGIRAVAQTAQMPTVQSIM 130
Query: 119 PDLVKPEELERANSIVMSASIISRLVGPAIGGFVYGFGGIKLAILMNAISF-FGSGLFEI 177
P +V +E+ R N + +V P IG F+ I IL++ I F G+G+ +
Sbjct: 131 PTMVPEDEITRVNGQFGIIQSLIVIVSPGIGAFMVATMPIHWVILLDVIGFILGAGML-L 189
Query: 178 FIKYEWKTRNIEGFSDFVRDIKEGLKFIMSNS--FISTLIGLVILLNALGAPFASIIYPY 235
++ E S +RD EG K + N + TLIG + +L L P A +YP
Sbjct: 190 LVRIPEVASQGEKIS-VIRDTLEGFKILRENKPMWKMTLIGALFML--LFMP-AMSLYPL 245
Query: 236 AMREILKFSSQQFGLVESAFMLGALIGNLIVGAFLGAKAGRYIFRLFLVNGAVELIFILI 295
+ + G VE F LIG+ VG F G R + + A LI L
Sbjct: 246 VTTKYFGGTIVHAGWVEVLFAAAMLIGSFAVGIF-GKTKDRMPWII-----AAYLIIGLS 299
Query: 296 ISPFLALPRN-SAFMLLLVLGATMGMAGAMINVPLASKLQRAVPSEIRGRVFSTMEMLAR 354
I LP N + F + LVL G+ G + + Q++ ++ GRV + L
Sbjct: 300 IGGSGFLPGNMNGFWVFLVLNVFAGIVGQIYTTMNMAITQQSFEAQYLGRVMGIVSALMS 359
Query: 355 IANPLSLVVVGPLVDTIG 372
IA P+ L+ P+ ++IG
Sbjct: 360 IAGPVGLIFAAPVAESIG 377
>gb|AAD42406.1|AF157493_14 (AF157493) putative transporter [Zymomonas mobilis]
Length = 431
Score = 101 bits (250), Expect = 1e-20
Identities = 89/381 (23%), Positives = 178/381 (46%), Gaps = 31/381 (8%)
Query: 4 NFWLFVAGRFISQLGWAIQEVALPLYVLD--VTHSAKIMTLFVLADLIPSIITTPIAGVF 61
N+ L+++G F+S +G +Q +A VL H+A + + P + P +G
Sbjct: 16 NYRLWISGMFVSNIGTWMQRIAQDWLVLVHLTHHNATAVGIITALQFAPVFLLLPFSGYA 75
Query: 62 GDRYDRKKIMVGFDLIRGVLLFLVIAFNFLTIRCLL------VVQVIMAIMNAFFSAGTG 115
D +DR+K ++ G+ + LT+ L+ + +I+ + A +
Sbjct: 76 ADHFDRRKFLIFTQAAMGLT---ALGLGILTLSGLVRLWHVYLFGLILGAITAIDAPARQ 132
Query: 116 AMYPDLVKPEELERANSIVMSASIISRLVGPAIGGFV---YGFGGIKLAILMNAISFFGS 172
+LVK E++ A ++ ++ +RL+GPAI GF+ +G GG+ L+NA SF
Sbjct: 133 TFVSELVKEEDIPNAVALNSTSFNSARLIGPAISGFLIAAFGSGGV---FLLNAASFGAV 189
Query: 173 GLFEIFIKYEWKTRNIEGFSDFVRDIKEGLKFIMSNSFISTLIGLVILLNALGAPFASII 232
L F++ + + + +D + +G +++ I T++ ++ L+ G F I
Sbjct: 190 ILALSFLRLD-ELYQRDKPTDQKHGLSDGFRYVRHRPDIKTILAMLFLICTFGLNFP--I 246
Query: 233 YPYAMREILKFSSQQFGLVESAFMLGALIGNLIVGAFLGAKAGRYIFRLFLVNGAVELIF 292
+ M + + +GL+ S+ +G++ G L F+ +A +I LFL ++F
Sbjct: 247 FISTMAVTVFHGERLYGLLMSSMAIGSVTGTL----FVAGQANPHIRLLFLST----ILF 298
Query: 293 ILIISPFLALPRNSAFMLLLVLGATMGMAGAMINVPLASKLQRAVPSEIRGRVFSTMEML 352
+ +P F L+LVL +G++ + S +Q + S++RGRV + + +
Sbjct: 299 GISCLLGALMPDALTFGLVLVL---IGLSAQIFTTASNSLVQLSTDSKVRGRVVAILLAV 355
Query: 353 ARIANPLSLVVVGPLVDTIGA 373
+ P+ +++G + D GA
Sbjct: 356 SVGGTPVGSLLIGRVADIWGA 376
>dbj|BAB04012.1| (AP001508) unknown conserved protein [Bacillus halodurans]
Length = 418
Score = 101 bits (248), Expect = 2e-20
Identities = 96/403 (23%), Positives = 181/403 (44%), Gaps = 29/403 (7%)
Query: 2 NRNFWLFVAGRFISQLGWAIQEVALPLYVLDVTHSAKIMTLFVLADLIPSIITTPIAGVF 61
N+ F L S L ++I + YV+D + + ++A +P ++ I GV
Sbjct: 23 NQKFLLLWVASIFSGLSFSIYFLTKSWYVVDELGLKTFLGVVLMAMTVPRVLLMMIGGVL 82
Query: 62 GDRYDRKKIMVGFDLIRGVLLFLVIAFNFL---TIRCLLVVQVIMAIMNAFFSAGTGAMY 118
DR+ R IM + R VLLF + FL I L+ + I++AFF A+
Sbjct: 83 ADRFRRSTIMFCSLITRSVLLFGMFILQFLGVINIWTLIGFAFCIGILDAFFWPANYAIL 142
Query: 119 PDLVKPEELERANSIVMSASIISRLVGPAIGGFV-------YGFGGIKLAILMNAISFFG 171
P +VK + L RANS + S + ++ ++GP I G++ + F I +++ AI F
Sbjct: 143 PSIVKKDHLTRANSFLQSTNHLTLIIGPMIAGWLITITAYEWIFVTIMCLLIIGAILIF- 201
Query: 172 SGLFEIFIKYEWKTRNIEGFSDFVRDIKEGLKFIMSNSFISTLIGLVILLNALGAPFASI 231
+ E F K E K ++D+ EG ++ + + +L+ + + +N ++
Sbjct: 202 -RVKEPFDKPETKR-----LPSPLKDLTEGYSYLRHSPVLLSLMWMSVFVNFFITGPGTM 255
Query: 232 IYPYAMREILKFSSQQFGLVESAFMLGALIGNLIVGAF-LGAKAGRYIFRLFLVNGAVEL 290
P + E LK + +ES G ++G +++G L +K G I V G
Sbjct: 256 AIPLIVEERLKGDPLELSYLESTIAGGLILGAIMIGIINLRSKRGLLIIIRLTVMGVAIA 315
Query: 291 IFILIISPFLALPRNSAFMLLLVLGATMGMAGAMINVPLASKLQRAVPSEIRGRVFSTME 350
+ ++S + A+ F+L A +GM ++ ++P + +Q + GRV M
Sbjct: 316 LLGQVVSLWQAI-----FVL-----AILGMGISIGDIPARAVVQEKTDFDKIGRVMGMMS 365
Query: 351 MLARIANPLSLVVVGPLVDTIGAWKTASFLWLGSGVVILYYWI 393
+ PLS + + ++ ++ L+ GS V++ +++
Sbjct: 366 TASSGLIPLSYGMTSVAL-SLNLSISSILLYCGSFVILFSFFV 407
>emb|CAA03986.1| (AJ000283) Tap protein [Mycobacterium fortuitum]
Length = 409
Score = 93.2 bits (228), Expect = 5e-18
Identities = 103/384 (26%), Positives = 162/384 (41%), Gaps = 27/384 (7%)
Query: 18 GWAIQEVALPLYVLDVTHSAKIMTLFVLADLIPSIITTPIAGVFGDRYDRKKIMVGFDLI 77
G I VA P VL SA ++ +A +P ++ T IAG D R+++ + DL+
Sbjct: 22 GNGITIVAFPWLVLQHNGSALDASIVAMAGTLPLLVATLIAGAAVDYLGRRRVSMISDLL 81
Query: 78 RG--VLLFLVIAFNFLTIRCLLVVQVIMAIMNAFFSAGTGAMYPDLVKPEE-------LE 128
V V+A F + V ++A + AFF G + + PE L+
Sbjct: 82 SALSVAAVPVLALIFGVDAVNVAVLAVLAGLGAFFDPA-GMTARETMLPEAAGRAGWTLD 140
Query: 129 RANSIVMSASIISRLVGPAIGGFVYG-FGGIKLAILMNAISFFGSGLFEIFIKYEWKTRN 187
ANS+ + + +VGP IGG + GGI + + A +F S L ++ E
Sbjct: 141 HANSVYEAVFNLGYIVGPGIGGLMIATLGGIN-TMWVTAGAFCCSILAISVLRLEGAGAP 199
Query: 188 IEGF--SDFVRDIKEGLKFIMSNSFISTLIGLVILLNALGAPFASIIYPYAMREILKFSS 245
+ I EGL+F+ + TL + ++ L P S+++P + +
Sbjct: 200 DRSVLTEAVLAGIVEGLRFVWYTPVLRTLAIVDLVATGLYMPMESVLFPKYFTD--RNEP 257
Query: 246 QQFGLVESAFMLGALIGNLIVGAFLGAKAGRYIFRLFLVNGAVELIFILIISPFLALPRN 305
+ G V A +G L+G L + R ++ V + I + P LP
Sbjct: 258 TELGWVLMALSIGGLLGALGYAVMSRYMSRRATMLTAVITLGVAMTVIAFLPP---LP-- 312
Query: 306 SAFMLLLVLGATMGMAGAMINVPLASKLQRAVPSEIRGRVFSTMEMLARIANPLSLVVVG 365
L+LVL A +G I +Q P +RGRV M LA A PL L++ G
Sbjct: 313 ----LILVLCAIVGFVYGPIAPIYNYVMQTTAPQHLRGRVVGVMGSLAYAAGPLGLILAG 368
Query: 366 PLVDTIGAWKTASFLWLGSGVVIL 389
PL D G A+FL L +++L
Sbjct: 369 PLADAAGL--HATFLALSLPMLLL 390
>sp|Q11060|YC58_MYCTU HYPOTHETICAL 43.3 KDA PROTEIN RV1258C >gi|7477990|pir||B70753
probable efflux protein - Mycobacterium tuberculosis
(strain H37RV) >gi|1480328|emb|CAB00894.1| (Z77137)
hypothetical protein Rv1258c [Mycobacterium
tuberculosis]
Length = 419
Score = 92.8 bits (227), Expect = 7e-18
Identities = 104/396 (26%), Positives = 177/396 (44%), Gaps = 31/396 (7%)
Query: 6 WLFVAGRFISQLGWAIQEVALPLYVLDVTHSAKIMTLFVLADLIPSIITTPIAGVFGDRY 65
+L + ++ G + VA P VL SA ++ A ++P + T +AG D +
Sbjct: 10 FLILFATLMAAAGDGVSIVAFPWLVLQREGSAGQASIVASATMLPLLFATLVAGTAVDYF 69
Query: 66 DRKKIMVGFDLIRGVLLFLV--IAFNFLTIRC-LLVVQVIMAIMNAFFSAGTGAMYPDLV 122
R+++ + D + G + V +A+ + +LV+ V+ A+ AF AG A D +
Sbjct: 70 GRRRVSMVADALSGAAVAGVPLVAWGYGGDAVNVLVLAVLAALAAAFGPAGMTAR--DSM 127
Query: 123 KPE-------ELERANSIVMSASIISRLVGPAIGGFVYGFGGIKLAILMNAISFFGSGLF 175
PE L+R N + ++ +VGPAIGG + G + + A +F S L
Sbjct: 128 LPEAAARAGWSLDRINGAYEAILNLAFIVGPAIGGLMIATVGGITTMWITATAFGLSILA 187
Query: 176 EIFIKYEW--KTRNIEGFSDFVRDIKEGLKFIMSNSFISTLIGLVILLNALGAPFASIIY 233
++ E K + V I EGL+F+ + + TL + + + AL P S+++
Sbjct: 188 IAALQLEGAGKPHHTSRPQGLVSGIAEGLRFVWNLRVLRTLGMIDLTVTALYLPMESVLF 247
Query: 234 PYAMREILKFSSQQFGLVESAFMLGALIGNLIVGAFLGAKAGRYIFRLFLVNGAVELIFI 293
P K+ + V+ + L A+ G +VGA A + R ++ AV + +
Sbjct: 248 P-------KYFTDHQQPVQLGWALMAIAGGGLVGALGYAVLAIRVPRRVTMSTAVLTLGL 300
Query: 294 --LIISPFLALPRNSAFMLLLVLGATMGMAGAMINVPLASKLQRAVPSEIRGRVFSTMEM 351
++I+ LP +++VL A +G+ I +Q +RGRV M
Sbjct: 301 ASMVIAFLPPLP------VIMVLCAVVGLVYGPIQPIYNYVIQTRAAQHLRGRVVGVMTS 354
Query: 352 LARIANPLSLVVVGPLVDTIGAWKTASFLWLGSGVV 387
LA A PL L++ GPL D G A+FL L +V
Sbjct: 355 LAYAAGPLGLLLAGPLTDAAGL--HATFLALALPIV 388
>gb|AAB84282.1| (AF030344) tetracycline-resistance determinant tetV [Mycobacterium
smegmatis]
Length = 419
Score = 92.8 bits (227), Expect = 7e-18
Identities = 84/372 (22%), Positives = 164/372 (43%), Gaps = 18/372 (4%)
Query: 3 RNFWLFVAGRFISQLGWAIQEVALPLYVLDVTHSAKIMTLFVLADLIPSIITTPIAGVFG 62
R + L +A +S + V + L V+ + + ++L + + + G+
Sbjct: 19 REYRLLIAAVTLSIFAEGMWSVVMALQVIAIDNDPASLSLVATCLGVGLVAFVLVGGITA 78
Query: 63 DRYDRKKIMVGFDLIRGVLLFLVIAF---NFLTIRCLLVVQVIMAIMNAFFSAGTGAMYP 119
DR +++ I++ +++ V + ++ A L I + V I+ I AFF A+ P
Sbjct: 79 DRINQRTIIIAVEVVNFVTVAVISALALLGVLKIWHMAVAAGILGIAAAFFFPAYSAILP 138
Query: 120 DLVKPEELERANSIV-MSASIISRLVGPAIGGFVYGFGGIKLAILMNAISF-FGSGLFEI 177
++ PE+L AN + + + R VGPA+ G V G + ++ A+ F G L
Sbjct: 139 RILPPEQLLAANGVEGVVRPVFQRSVGPAVAGMVIGATMPSIGAVVVAVLFALGLALLVA 198
Query: 178 FIKYEWKTRNIEGFSDFVRDIKEGLKFIMSNSFI--STLIGLVILLNALGAPFASIIYPY 235
+RD++EG F++ ++ + L + +L LG ++ P+
Sbjct: 199 TRPPAQPASEHHERPHVLRDLREGFAFVLKTPWLLWTVLFASMFVLVVLGP--IEVLLPF 256
Query: 236 AMREILKFSSQQFGLVESAFMLGALIGNLIVGAFLGAKAGRYIFRLFLVNGAVELIFILI 295
++ ++ +G + + F +G+ +G L V + + RY+ + L+ G +
Sbjct: 257 IAQDRFADGARAYGFILAFFGIGSAMGALTVSSRRMPR--RYLTTMMLMWGLGSI----- 309
Query: 296 ISPFLALPRNSAFMLLLVLGATMGMAGAMINVPLASKLQRAVPSEIRGRVFSTMEMLARI 355
P + + S+F L+ +G+ V + LQR VP+E+ GRV S ++
Sbjct: 310 --PLVIVGYTSSFPLMAAATFVIGVTDGAGMVIWGTLLQRRVPTEMLGRVSSLDFFVSLA 367
Query: 356 ANPLSLVVVGPL 367
PLS +VGPL
Sbjct: 368 FMPLSFAIVGPL 379
>pir||C70046 macrolide-efflux protein homolog yvqJ - Bacillus subtilis
>gi|2635811|emb|CAB15304.1| (Z99120) similar to
macrolide-efflux protein [Bacillus subtilis]
>gi|2832815|emb|CAA11739.1| (AJ223978) putative
macrolide-efflux determinant, YvqJ [Bacillus subtilis]
Length = 422
Score = 92.8 bits (227), Expect = 7e-18
Identities = 85/385 (22%), Positives = 171/385 (44%), Gaps = 39/385 (10%)
Query: 42 LFVLADLIPSIITTPIAGVFGDRYDRKKIMVGFDLIRGVLLFLVIAFNFLTIRCLLVVQV 101
L + +P + P+ G F + K M DL R ++ ++ +F L V
Sbjct: 52 LLIAVTFLPEAVLAPVTGPFMKQTTLKFWMYFSDLTRAAIVLIIPLCHFAGFSPLWFVMT 111
Query: 102 IMAIMNAF---FSAGTGAMYPDLVKPEELERANSIVMSASIISRLVGPAIGGFVYGFGGI 158
+M + +A ++ + A+ P +V + +++AN+++ S++ I RL + G F
Sbjct: 112 LMIVHSATGAAYNPASIALIPQIVNEQGIQKANAVLQSSAQIVRLGAVTLCGAFLTFISP 171
Query: 159 KLAILMNAISFFGSGLFEIFIKY-----EWKTRNIEGFSDFVRDIKEGLKFIMSNSFIST 213
+L+ + + SG +FIKY + ++ + ++ +K G + + + +
Sbjct: 172 SYTMLIALVLYLVSGFLVLFIKYTAVESQSESAVVTQRGTYIGRLKRGFRLVRKHQILYP 231
Query: 214 LIGLVILLNALGAPFASIIYPYAMREI----LKFSSQQFGLVESAFMLGALIGNLIVGAF 269
L I +N AP+ ++ Y ++ + +S + AF+LG ++ +
Sbjct: 232 LAIYCIFMNFAAAPWEALSAVYVAEDLNGQPIVYSLLKATTAAGAFLLGFVLAKV----- 286
Query: 270 LGAKAGRYIFRLFLVNGAVE--LIFILIISPFLALPRNSAFMLLLVLGATMGMAGAMINV 327
K RY LF+ G +E FI ++ FL L +AF T G A + +NV
Sbjct: 287 ---KVNRYGL-LFVTAGIIEGFAFFITGMNTFLPLVFFAAF--------TFGAAVSAVNV 334
Query: 328 PLASKLQRAVPSEIRGRVFSTMEMLARIANPLSLVVVGPLVDTIGAWK---TASFLWLGS 384
P + +Q +V SE + +V++ + M++ I+ P V+ G + G+ K + + +
Sbjct: 335 PEYTIIQTSVDSEDQPQVYAVIHMISNISIPAGAVICGYAANAFGSGKVIAVGGIVEIIA 394
Query: 385 GVVILYYWIFKGKELTSEEESKLVE 409
G+ IL + +L E S L++
Sbjct: 395 GIGILLF-----TKLAKAERSDLIK 414
>pir||T28700 hypothetical protein - Streptomyces coelicolor
>gi|3127851|emb|CAA18917.1| (AL023496) hypothetical
protein [Streptomyces coelicolor A3(2)]
Length = 630
Score = 92.4 bits (226), Expect = 9e-18
Identities = 99/404 (24%), Positives = 175/404 (42%), Gaps = 39/404 (9%)
Query: 5 FWLFVAGRFISQLGWAIQEVALPLYVLDVTHSAKIMTLFVLADLIPSIITTPIAGVFGDR 64
F LF + S L I ++A+PL L ++ SA + LA +P +I T AGV DR
Sbjct: 21 FRLFQSAVVSSDLADGIYKIAVPLLALGISRSAVAVGAVGLAVRLPWLIATLPAGVLADR 80
Query: 65 YDRKKIMVGFDLIRGVLLFLVIAF---NFLTIRCLLVVQVIMAIMNAFFSAGTGAMYPDL 121
Y + +M +R L+ + A + L + L+V ++ F + P L
Sbjct: 81 YPPRSVMRWASAVRLPLVAAMCALAATDRLPLWALVVTAFLIGCAGIFVDVAAQSQLPRL 140
Query: 122 VKPEELERANSIVMSASI-ISRLVGPAIGGFVYGF---GGIKLAILMNAISFFGSGLFEI 177
V +L +AN+ + S + +++L+GPA+GG+V GG+ + + + ++ +G GL
Sbjct: 141 VPVGQLPKANASLQSTQMFLAQLIGPALGGYVVALGSGGGLAVVVALYVVTVWGLGLLPA 200
Query: 178 FIKY--EWKTRNIEG-----------FSDFVRDIKEGLKFIMSNSFISTLIGLVILLNAL 224
++ R G F V ++ EGL++ ++ L + N
Sbjct: 201 AVEQAAAGHARPATGPARAGGGRRSSFGSLVAELGEGLRYFRGRGDLARLATAAAVNNLS 260
Query: 225 GAPFASIIYPYAMRE-ILKFSSQQFGLVESAFMLGALIGNLIVGAFLGAKAGRYIFRLFL 283
+ +++ +A+R L S +GL+ + +G+++ L+ G L A + R
Sbjct: 261 YSMCLTMLPLWAVRPGRLGLSETGYGLLLTFLAVGSILAGLVTGRILDAVGDGPVMRF-- 318
Query: 284 VNGA--VELIFILIISPFLALPRNSAFMLLLVLGA-TMGMAGAMINVPLASKLQRAVPSE 340
GA + L F+ + P A+P ++ LG G+ + NV + S Q +P
Sbjct: 319 --GAPLLGLCFLALAVP--AVP-------VIALGLFVYGLVSMVWNVTVTSYRQATIPLP 367
Query: 341 IRGRVFSTMEMLARIANPLSLVVVGPLVDTIGAWKTASFLWLGS 384
+ GRV + L P + G L T G T FL G+
Sbjct: 368 LFGRVNAAYRWLTWGVIPFGSLFGGTLAATAGT--TWVFLTAGA 409
>gb|AAF74725.1|AF251288_2 (AF251288) MefEn2 [Bacteroides fragilis]
Length = 401
Score = 90.5 bits (221), Expect = 3e-17
Identities = 91/382 (23%), Positives = 170/382 (43%), Gaps = 15/382 (3%)
Query: 11 GRFISQLGWAIQEVALPLYVLDVTHSAKIMTLFVLADLIPSIITTPIAGVFGDRYDRKKI 70
G+ IS L I ++ ++ + S ++L +LA +P + AGV+ DR++RKK
Sbjct: 14 GQLISILTSTIVGFSIIFWISNEFKSPTALSLAILAGFLPQFVLGLFAGVYVDRWNRKKT 73
Query: 71 MVGFDLIRG---VLLFLVIAFNFLTIRCLLVVQVIMAIMNAFFSAGTGAMYPDLVKPEEL 127
M DL + LF+VI + + ++ +I + F + A P LV L
Sbjct: 74 MFYSDLFIAFCTLCLFIVITKGYKDLSFFYLLTACRSIGSTFHAPALQASIPLLVPKHHL 133
Query: 128 ERANSIVMSASIISRLVGPAIGGFVYGFGGIKLAILMNAISFFGSGLFEIFIKYEWKTRN 187
R + + S S ++ P +G + + I+ +L++ I + L + ++ +
Sbjct: 134 VRVSGLYHSIQSFSEVIAPVVGASLVVWLPIQYILLIDVIGAVAACLTLLCVQIP-SLQK 192
Query: 188 IEGFSDFVRDIKEGLKFIMSNSFISTLIGLVILLNALGAPFASIIYPYAMREILKFSSQQ 247
+ DF +++ E L + I L L+ + P + ++P+ + Q
Sbjct: 193 TKVLPDFKKELTEWLHTLRRTMGILPLFVCFTLVTFVLMPVFT-LFPFMTLLHFNGNILQ 251
Query: 248 FGLVESAFMLGALIGNLIVGAFLGAKAGRYIFRLFLVNGAVELIFILIISPFLALPRNSA 307
G+VE + GAL+G L+ L KA + L + V L LI + +L +SA
Sbjct: 252 MGVVEMGWGSGALLGGLV----LACKALKSKQTLVMHTAYVILGLYLISASYLP---SSA 304
Query: 308 FMLLLVLGATMGMAGAMINVPLASKLQRAVPSEIRGRVFSTMEMLARIANPLSLVVVGPL 367
F+ + L T G+A ++ + + +Q+ + S++ GR FS + L+ + L +V G
Sbjct: 305 FIGFVCLTFTGGIAYSIYHALFIAIIQQNLASDMLGRTFSLIFSLSTFPSMLGIVASGYW 364
Query: 368 VDTIGAWKTASFLWLGSGVVIL 389
V+ AW S + V+ L
Sbjct: 365 VE---AWGITSVFMISGWVIFL 383
>pir||S74444 hypothetical protein sll1204 - Synechocystis sp. (strain PCC 6803)
>gi|1651668|dbj|BAA16596.1| (D90899) hypothetical
protein [Synechocystis sp.]
Length = 427
Score = 89.7 bits (219), Expect = 6e-17
Identities = 85/388 (21%), Positives = 175/388 (44%), Gaps = 25/388 (6%)
Query: 3 RNFWLFVAGRFISQLGWAIQEVALPLYVLDVTHSAKIMTLFVLADLIPSIITTPIAGVFG 62
+ F G+ +S +G + +L +++ T+SA + L ++ +P II TP++G+
Sbjct: 2 KTFVTLCLGQALSSIGSGMTYFSLTIWIWQKTNSAMSVALILVFYQLPQIIITPLSGILT 61
Query: 63 DRYDRKKIMVGFDLIRGVLLFLVIAFNFLTIRCLLVVQVIMAIMNAFFSAGTGA---MYP 119
D + KK+++ D+ V F V FL I + + +I +I+ F + T + + P
Sbjct: 62 DYFSHKKLLIVSDIGSAVCTFSVGILAFLQILNVKYIYLIASIIGCFGNIQTLSYITLVP 121
Query: 120 DLVKPEELERANSIVMSASIISRLVGPAIGGFVYGFGGIKLAILMNAISFFGSGLFEIFI 179
+V + RA+S+ + + +V PA+ G ++ G+ +++ +F + + + +
Sbjct: 122 LIVPYQHHARASSMGAITAYSAGIVAPALAGILFPVMGLTGITIIDMTTFMIAAITILIL 181
Query: 180 KYEWKTRN----------IEGFSDFVRDIKEGLKFIMSNSFISTLIGLVILLNALGAPFA 229
+ ++ + +FV DI GLK+I ++ +S ++ ++ L +
Sbjct: 182 PIAFGIKSPKITNQTLFVVRLKENFVDDIFFGLKYIYNHPNLSKIL-IIFSLFSFVEGIT 240
Query: 230 SIIYPYAMREILKFSSQQFGLVESAFMLGALIGNLIVGAFLGAKAGRY-IFRLFLVNGAV 288
+IY + +++ G++ + +G ++G I + G K IF F++NG
Sbjct: 241 EVIYQPMILAKTGGNTEILGIIVAIGGVGGIVGGTICSIWGGFKRRTTGIFIGFIINGFS 300
Query: 289 ELIFILIISPFLALPRNSAFMLLLVLGATMGMAGAMINVPLASKLQRAVPSEIRGRVFST 348
L LI P F LL +GA+ + +I + V EI+GRV +
Sbjct: 301 RLAMGLIAQP--------KFWLLANVGAS--LPSPLITSSYTAIWYEKVAREIQGRVLAA 350
Query: 349 MEMLARIANPLSLVVVGPLVDTIGAWKT 376
++ + + LS + G L + I T
Sbjct: 351 DYLIGTVISSLSGLAAGILANQISVMLT 378
>dbj|BAB12240.1| (AB038042) Mrx [Escherichia coli]
Length = 412
Score = 87.8 bits (214), Expect = 2e-16
Identities = 87/368 (23%), Positives = 162/368 (43%), Gaps = 17/368 (4%)
Query: 10 AGRFISQLGWAIQEVALPLYVLDVTHSAKIMTLFVLADLIPSIITTPIAGVFGDRYDRKK 69
A F+ ++G A+ +ALP +VL T SA + +I +II + G DR+ R
Sbjct: 14 AATFLFRIGNAVAALALPWFVLSHTKSAAWAGATAASSVIATIIGAWVGGGLVDRFGRAP 73
Query: 70 IMVGFDLIRGVLLF---LVIAFNFLTIRCLLVVQVIMAIMNAFFSAGTGAMYPDL--VKP 124
+ + ++ GV + L+ A L+ L+ V+ A +A A + P L V
Sbjct: 74 VALISGVVGGVAMASIPLLDAVGALSNTGLIACVVLGAAFDAPGMAAQDSELPKLGHVAG 133
Query: 125 EELERANSIVMSASIISRLVGPAIGGFVYGFGGIKLAILMNAISFFGSGLFEIFIKYEWK 184
+ER +S+ ++ L GPA+GG G G + + A +GL ++
Sbjct: 134 LSVERVSSLKAVIGNVAILGGPALGGAAIGLLGAAPTLGLTAFCSVLAGLLGAWVLPARA 193
Query: 185 TRNIEGFSDFVRDIKEGLKFIMSNSFISTLIGLVILLNALGAPFASIIYPYAMREILKFS 244
R + + ++ G+ F+ S + L G+V++ + S+I P + +
Sbjct: 194 ARTMTTTATL--SMRAGVAFLWSEPLLRPLFGIVMIFVGIVGANGSVIMPALFVDAGR-Q 250
Query: 245 SQQFGLVESAFMLGALIGNLIVGAFLGAKAGRYIFRLFLVNGAVELIFILIISPFLALPR 304
+ GL S G L+G + + A +GA+ + G+ + L++S +P
Sbjct: 251 VAELGLFSSMMGAGGLLG-IAIHASVGARISAQNWLAVAFCGSA--VGSLLLSQLPGVP- 306
Query: 305 NSAFMLLLVLGATMGMAGAMINVPLASKLQRAVPSEIRGRVFSTMEMLARIANPLSLVVV 364
+L++LGA +G+ ++ L + + P E+ GRV T+ + A+P+ ++
Sbjct: 307 -----VLMLLGALVGLLTGSVSPILNAAIYNRTPPELLGRVLGTVSAVMLSASPMVMLAA 361
Query: 365 GPLVDTIG 372
G VD G
Sbjct: 362 GAFVDLAG 369
>pir||G75408 probable transport protein - Deinococcus radiodurans (strain R1)
>gi|6459076|gb|AAF10896.1|AE001979_2 (AE001979)
transport protein, putative [Deinococcus radiodurans]
Length = 430
Score = 87.4 bits (213), Expect = 3e-16
Identities = 94/423 (22%), Positives = 175/423 (41%), Gaps = 40/423 (9%)
Query: 3 RNFWLFVAGRFISQLGWAIQEVALPLYVLDVT-HSAKIMTLFVLADLIPSIITTPIAGVF 61
R +W + +S +G +Q A VL+++ +S+ + +A +PS++ + AG
Sbjct: 22 RRYWF---SQLLSLIGSWMQSTAQQYLVLELSGNSSAALAQVTIAQFLPSLLLSLFAGAV 78
Query: 62 GDRYDRKKIMVGFDLI---RGVLLFLVIAFNFLTIRCLLVVQVIMAIMNAFFSAGTGAMY 118
DR R+++++ + + L + +++ ++V I I NAF M
Sbjct: 79 VDRVPRRRVLLTTQITLMTTAIALAVTTHQGSVSVPLVMVFAFISGIANAFDMPARQTMV 138
Query: 119 PDLVKPEELERANSIVMSASIISRLVGPAIGGFVYGFG-------------GIKLAILMN 165
D V E++ A ++ + +SR +G A+ G V G + L +N
Sbjct: 139 VDFVPREQVSNAVALNSLSFNVSRTIGQALFGVVAALGVSLLAGGNPDSVARLALPFYLN 198
Query: 166 AISFFGSGLFEIFIKYEWKTRNIEGFSDFVRDIKEGLKFIMSNSFISTLIGLVILLNALG 225
+SF + + + G V D++EGL+++ ++ + ++ LV L+
Sbjct: 199 VVSFL--VVLFVIATLPFPPVQERGNHSMVDDVREGLRYVKTHPGVRNVMLLVGALSLTV 256
Query: 226 APFASIIYPYAMREILKFSSQQFGLVESAFMLGALIGNLIVGAFLGAKAGRYIFRLFLVN 285
F ++I PY R + FGL+ + F +GA+ GA A + L L
Sbjct: 257 INF-NVIIPYYARVVYGAREATFGLLSAGFGIGAM-----AGALWQASKPNPVRNLRL-- 308
Query: 286 GAVELIFILIISPFLALPRNSAFMLLLVLGATMGMAGAMINVPLASKLQRAVPSEIRGRV 345
GA L++ LAL + L L + A G + S +Q ++P +RGRV
Sbjct: 309 GAT-----LVMLSSLALSAVPSAALALPVLAACGFGMLTFLISANSTVQLSIPDALRGRV 363
Query: 346 FSTMEMLARIANPLSLVVVGPLVDTIG----AWKTASFLWLGSGVVILYYWIFKGKELTS 401
S + P + L+ G W + + LG+ + + W +EL S
Sbjct: 364 MSLYSFVLVGMGPAGAALASTLISREGPLGPRWGLVTLVVLGA-IALALLWTRLPRELPS 422
Query: 402 EEE 404
+ E
Sbjct: 423 QRE 425
>pir||H69812 conserved hypothetical protein yfmI - Bacillus subtilis
>gi|2443252|dbj|BAA22323.1| (D86417) YfmI [Bacillus
subtilis] >gi|2633070|emb|CAB12575.1| (Z99108) similar
to hypothetical proteins [Bacillus subtilis]
Length = 406
Score = 84.7 bits (206), Expect = 2e-15
Identities = 79/405 (19%), Positives = 183/405 (44%), Gaps = 17/405 (4%)
Query: 1 MNRNFWLFVAGRFISQLGWAIQEVALPLYVLDVTHSAKIMTLFVLADLIPSIITTPIAGV 60
M++ ++ + + + LG+++ + + ++ +T+S I ++ L +I I + I +
Sbjct: 1 MSKGYYSILFSQTTTNLGFSLYTMVVISFLFKMTNSTTIASMVTLISIIFRIFGSAILPL 60
Query: 61 FGDRYDRKKIMVGFDLIRGVLLF-----LVIAFNFLTIRCLLVVQVIMAIMNAFFSAGTG 115
R ++ LI+ +LL L+ ++ T+ + ++ ++ N +FS
Sbjct: 61 ITIRLKLPLTIIISQLIQMLLLICLFYALLRTYSNQTLILVFIIISCISFFNGWFSPLKS 120
Query: 116 AMYPDLVKPEELERANSIVMSASIISRLVGPAIGGFVYGFGGIKLAILMNAISFFGSGLF 175
A+ +++ P+ +AN ++ + + VG ++GG + F G I++ F S L
Sbjct: 121 AIIGEIISPDRRVKANGLLSTVDQTFQFVGWSLGGLIIAFLGEGYTIILTIFLLFTSLLS 180
Query: 176 EIF-IKYEWKTRNIEGFSDFVRDIKEGLKFIMSNSFISTLIGLVILLNALGAPFASIIYP 234
+F + + I + + I G +++ S + T+I + ++ + G + +
Sbjct: 181 LLFCLPHGHANSVIREKNSPNKSIVSGWRYLFSQKKLRTIIIMDLIESWAGMIWIGSVSL 240
Query: 235 YAMREILKFSSQQFGLVESAFMLGALIGNLIVGAFLGAKAGRYIFRLFLVNGAVELIFIL 294
+ E+L +G + A+ LG++IG I+ + I F++ GAV +
Sbjct: 241 AFVNEVLHKGESWWGFINGAYYLGSMIGGFIIYKLSERFQNKLI--NFMLIGAVSYGSLT 298
Query: 295 IISPFLALPRNSAFMLLLVLGATMGMAGAMINVPLASKLQRAVPSEIRGRVFSTMEMLAR 354
+I F++ NS L+LVL MG A + ++ + +Q + R + S L +
Sbjct: 299 LIYGFIS---NSYLALILVL--FMGPAYILRDLTQETLIQNITTEQTRINIMSARSSLVQ 353
Query: 355 IANPLSLVVVGPLVDTIGAWKTASFLWLGSGVVILYYWIFKGKEL 399
S++ +G + D +G +++ +G+++L I+ +L
Sbjct: 354 FIFMFSILAIGAISDFLG----VRLVYVSAGILLLVSAIYGFSQL 394
>pir||E69804 multidrug resistance protein homolog yfiS - Bacillus subtilis
>gi|2633162|emb|CAB12667.1| (Z99108) similar to
multidrug resistance protein [Bacillus subtilis]
>gi|2804523|dbj|BAA24459.1| (D85082) YfiS [Bacillus
subtilis]
Length = 417
Score = 84.7 bits (206), Expect = 2e-15
Identities = 93/412 (22%), Positives = 176/412 (42%), Gaps = 20/412 (4%)
Query: 9 VAGRFISQLG-WAIQEVALPLYVLDVTHSAKIMTLFVLADLIPSIITTPIAGVFGDRYDR 67
+A + IS LG W L L + S M+L +++ +P I+ P++G+ DR+DR
Sbjct: 16 LASQTISSLGDWLHILAVLTLAAFQLHASPLDMSLLMMSFALPVIVLGPVSGLLADRFDR 75
Query: 68 KKIMVGFDLIRGVLLFLVIAFNFLTIRCLLVVQVIMAIMNAFFSAGTGAMYPDLVKPEEL 127
K IM ++ R + + + + L L V+ + + ++ F +L +
Sbjct: 76 KTIMFLSEIGRALTVISCVYVSELWQ--LYVLLSVQSCFSSLFLPAKNGKLKELAPEAHI 133
Query: 128 ERANSIVMSASIISRLVGPAIGGFVYGFGGIKLAILMNAISFFGSGLFEIFIKYE---WK 184
++A S+ S++ GPA+GG + I +NA +FF S + F+ + K
Sbjct: 134 QQAVSVSSIIDNSSKIFGPALGGTLIAAFSIHSVFYINAGAFFLSAVILFFLPRDAFLQK 193
Query: 185 TRNIEGFSDFVRDIKEGLKFIMSNSFISTLI---GLVILLNALGAPFASIIYPYAMREIL 241
+ + + IKEGL+F+ + T + +V+ + +G A I+ I
Sbjct: 194 ANTPQEKTAALTSIKEGLQFLKRMPLLLTGLLTACVVLFVLQIGDSQAIIL-------IR 246
Query: 242 KFSSQQFGLVESAFMLGALIGNLIVGAFLGAKAGRYIFRLFLVNGAVELIFILIISPFLA 301
FS L + G L+ A G + + L+ G + L +PFL+
Sbjct: 247 SFSGAPPELAGWCMAVSGA-GMLLTAAITGRRRITS-YLLYFSAGTLLLGLATGGAPFLS 304
Query: 302 LPRNSAFMLLLVLGATMGMAGAMINVPLASKLQRAVPSEIRGRVFSTMEMLARIANPLSL 361
+ L + MG A ++++P +Q VP + GRVF ++ +A+ L +
Sbjct: 305 GMGIAGITLFIFAFFIMGAAFGLVHIPFQILVQTTVPVDYSGRVFGAIQSATTLASILGM 364
Query: 362 VVVGPLVDTIGAWKTASFLWLGSGVVILYYWIFKGKELTSEEESKLVENFPG 413
G L + IG + +FL G ++++ GK++ + ++ G
Sbjct: 365 AGGGVLAEWIGV--SLAFLVCGCLLIMIGLITLIGKKIAESRRYLVTKSNKG 414
>pir||B75051 hypothetical protein PAB1450 - Pyrococcus abyssi (strain Orsay)
>gi|5458816|emb|CAB50303.1| (AJ248287) hypothetical
protein [Pyrococcus abyssi]
Length = 428
Score = 83.5 bits (203), Expect = 4e-15
Identities = 91/386 (23%), Positives = 171/386 (43%), Gaps = 18/386 (4%)
Query: 3 RNFWLFVAGRFISQLGWAIQEVALPLYVLDVTHSAKIMTLFVLADLIPSIITTPIAGVFG 62
R + LF+ + +G AI+ V+LP ++L+ T+S + + LA ++P +I P+ G F
Sbjct: 46 RLYALFLLTTVLRIVGDAIEGVSLPWHLLNKTNSLLSIAGYSLASMLPWVIFPPLIGNFL 105
Query: 63 DRYDRKKIMVGFDLIRGVLLFLVIAFNFLTIRCL-LVVQVIMAIMNAFFSAGTGAMYPDL 121
DR ++K + L L + + +R L++ +I A+ G +
Sbjct: 106 DRTEKKVRLAFLALFAQSFLAITLVRFAQDVRIFYLLISLISALDTLHRYYGFSLIAFMT 165
Query: 122 VKPEELERANSIVMSASIISRLVGPAIGGFVYGFGGIKLAILMNAISFFGSGLFEIFIKY 181
++ EL++ N+ V + ++ L I G++ GIKL +L G+ L +I
Sbjct: 166 LEESELQKLNAKVQTIGGVTSLFSFPIMGYLAYLFGIKLMLLDALFLLIGALLLVPYI-- 223
Query: 182 EWKTRNIEGFSDFVRDIKEGLKFIMSNSFISTLIGLVILLNALGAPFASIIYPYAMREIL 241
N+ R KE LK +S + G++++L A ++ I+ + L
Sbjct: 224 -----NVSVRRGESRKEKECLKIEISRKIV--FAGIILILTFNFAIASARIFIFNALRTL 276
Query: 242 KFSSQQFGLVESAFMLGALIGNLIVGAFLGAKAGRYIFRLFLVNGAVELIFILIISPFLA 301
+GL+ S LG+LI + F+ K I + ++ +E + +L + F
Sbjct: 277 AKGEVLYGLLRSLGTLGSLISAFGI-VFIAHKFRIGILKPLVIGMMLESLAVLFLG-FSL 334
Query: 302 LPRNSAFMLLLVLGATMGMAGAMINVPLASKLQRAVPSEIRGRVFSTMEMLARIANPLSL 361
LP A +LLL G G ++N+ S Q+ +P E G + LA + P+S
Sbjct: 335 LPLLLAGVLLLSFG------GEILNISFDSLFQKVIPLERLGTYRGVFDALATLIIPISQ 388
Query: 362 VVVGPLVDTIGAWKTASFLWLGSGVV 387
+ L++ +F+ G+G++
Sbjct: 389 LTFAWLIEKGFNVPMLAFIAFGAGII 414
>pir||S77010 nickel resistance protein nreB - Synechocystis sp. (strain PCC
6803) >gi|1001821|dbj|BAA10702.1| (D64005) nickel
resistance [Synechocystis sp.]
Length = 445
Score = 82.7 bits (201), Expect = 7e-15
Identities = 89/352 (25%), Positives = 158/352 (44%), Gaps = 21/352 (5%)
Query: 2 NRNFWLFVAGRFISQLGWAIQEVALPLYVLDVTHSAKIMTLFVLADLIPSI--ITTPIAG 59
NR F + IS LG A+ V L L ++ + L L ++ + +PIAG
Sbjct: 13 NRLFAQLYLAQAISLLGDALTWVGLALLAFELAGQGAGLILAGALTLRVTVFVLLSPIAG 72
Query: 60 VFGDRYDRKKIMVGFDLIRGVLLFLVIAFNFLTIRCLLVVQVI-MAIMNAFFSAGTGAMY 118
DRYDRK++MV L R L +V F +T + V+ + + NAFF+ A
Sbjct: 73 AIADRYDRKQMMVITHLAR---LGIVCLFPGVTQAWQIYGLVLGLNVFNAFFTPTYTATI 129
Query: 119 PDLVKPEELERANSIVMSASIISRLVGPAIGGFVYGFGGIKLAILMNAISF-FGSGLFEI 177
P + K +E +A ++ + + ++GP + G + + G K +A++F +GL
Sbjct: 130 PLVTKEDEYPQAIALSSATYQLLGVLGPGLAGSLAAWVGTKTIFWGDALTFLMAAGLIFT 189
Query: 178 F---IKYEWKTRNIEGFSDFVRDIKEGLKFIMSNSFISTLIGLVILLNALGAPFASIIYP 234
+ + + + RDI G + + + I + + ++++ GA
Sbjct: 190 LPGKLLANSTAQPVRNLAQIRRDIGTGTQCLFGDRLIRYALAMQLVVSLAGAGILVNTVG 249
Query: 235 YAMREILKFSSQQFGLVESAFMLGALIGNLIVGAFLGAKAGRYIFRLFLVNGAVELIFIL 294
Y ++ IL ++G + +AF LGA + +L +G + R L + V + IL
Sbjct: 250 Y-VQGILNLGKLEYGWLMAAFGLGATVASLGLG---NTQQQRKRIYLTTIGAVVMSLAIL 305
Query: 295 IISPFLALPRNSAFMLLLVLGATMGMAGAMINVPLASKLQRAVPSEIRGRVF 346
+S N +LLL GA G+ ++NVP + + V E++GRV+
Sbjct: 306 PVSMV-----NLQGLLLLWAGA--GIGQTLVNVPTQTLIADRVAKELQGRVY 350
>dbj|BAB04526.1| (AP001509) unknown conserved protein [Bacillus halodurans]
Length = 417
Score = 82.3 bits (200), Expect = 1e-14
Identities = 80/347 (23%), Positives = 160/347 (46%), Gaps = 29/347 (8%)
Query: 14 ISQLGWAIQEVALPLYVLDVTHSAKIMTLFVLADLIPSIITTPIAGVFGDRYDRKKIMVG 73
IS +G + +AL L V +T SA + L + +I+T G DR ++K++M+G
Sbjct: 21 ISSIGVWVYFIALNLIVFQMTGSALAVAALYLIRPLATIVTNWWCGSVIDRMNKKRLMIG 80
Query: 74 FDLIRGVLL-FLVIAFNFLTIRCLLVVQVIMAIMNAFFSAGTGAMYPDLVKPEELERANS 132
D+I+G L+ L IA + L + +LV + MA + + + + L+ + +R NS
Sbjct: 81 LDVIQGGLITLLAIASSSLWLIYVLVFFIHMAA--SVYHPTSMSYITRLIPAHQRQRFNS 138
Query: 133 IVMSASIISRLVGPAIGGFVYGFGGIKLAILMNAISFFGSGLFEIF---IKYEWKTRNIE 189
+ + +GPAI G ++ G AI++NA + F S + F ++ E K + ++
Sbjct: 139 LRSLLDSGAFFIGPAITGVLFLIGTPVYAIIINAGALFFSAVVTCFMPNVEKEQKQKKVK 198
Query: 190 GFSDF-VRDIKEGLKFIMSNSFISTLI--------GLVILLNALGAPFASIIYPYAMREI 240
+ +K+ +F++S S + + G +++ A+ + + +E+
Sbjct: 199 KTKKMSLHLLKDDWRFVISFSRMHVYVISVYVLFSGFIVMQTAIDSLEVAF-----SKEV 253
Query: 241 LKFSSQQFGLVESAFMLGALIGNLIVGAFLGAKAGRYIFRLFLVNGAVELIFILIISPFL 300
L + ++G + S G L+G+ + AF Y+ + +F+ + +L
Sbjct: 254 LLLTDSEYGFLVSLAGAGILVGSFLNVAFAKKWGISYLI-------GIGSVFVAV--GYL 304
Query: 301 ALPRNSAFMLLLVLGATMGMAGAMINVPLASKLQRAVPSEIRGRVFS 347
+S+F++ V + +A A N + Q +P E+ GR+ S
Sbjct: 305 IFAFSSSFVIASVGVFVLALANAFANTGFMTFYQNNIPVEVMGRIAS 351
>emb|CAB93411.1| (AL357524) putative integral membrane efflux protein [Streptomyces
coelicolor A3(2)]
Length = 459
Score = 81.9 bits (199), Expect = 1e-14
Identities = 83/377 (22%), Positives = 156/377 (41%), Gaps = 22/377 (5%)
Query: 3 RNFWLFVAGRFISQLGWAIQEVALPLYVLDVTHSAKIMTLFVLADLIPSIITTPIAGVFG 62
RN+ LF G+ +S +G +Q +A VL +T S+ + + +P ++ GV
Sbjct: 43 RNYRLFFMGQVVSNIGTWMQRIAQDWLVLSLTGSSAAVGITTALQFLPMLLFGLYGGVLV 102
Query: 63 DRYDRKKIMVGFDLIRGVLLFLVIAFNF---LTIRCLLVVQVIMAIMNAFFSAGTGAMYP 119
DR ++ ++ + + A + + + V M + +
Sbjct: 103 DRLPKRPTLLVTQTAMALTALALAALTLSGHVQVWHVYVAAFAMGLATVMDNPARQTFVS 162
Query: 120 DLVKPEELERANSIVMSASIISRLVGPAIGGFVYGFGGIKLAILMNAISFFGSGLFEIFI 179
+LV ++L+ A S+ + +RLVGPA+ G + G A L N +SF + +
Sbjct: 163 ELVGRDQLQNAVSMNSANFQSARLVGPAVAGLMITGVGTGWAFLANGLSFVAPLTCLLLM 222
Query: 180 KYEWKTRNIEGFSDFVR---DIKEGLKFIMSNSFISTLIGLVILLNALGAPFASIIYPYA 236
+ R + R ++EGL+++ + I LV + G F + +A
Sbjct: 223 R----ARELHAGRPTPRGKGQLREGLRYVAGRPELIWTITLVGFIGTFGFNFPVFLSAFA 278
Query: 237 MREILKFSSQQFGLVESAFMLGALIGNLIVGAFLGAKAGRYIFRLFLVNGAVELIFILII 296
++ + + L + +G+L G L+ A G R + L GA+E++
Sbjct: 279 -DDVFDAGAGAYSLFNTLMAVGSLAGALLA-ARRGTARLRVLIAAALGFGALEIVAS--- 333
Query: 297 SPFLALPRNSAFMLLLVLGATMGMAGAMINVPLASKLQRAVPSEIRGRVFSTMEMLARIA 356
P F LL+V +G+ +NV + +Q + +RGRV + M+
Sbjct: 334 ----TAPELWLFALLMV---PIGVFSMTVNVTANTSIQMSTDPAMRGRVMALYMMVFLGG 386
Query: 357 NPLSLVVVGPLVDTIGA 373
+P+ +VG + DT GA
Sbjct: 387 SPVGAPIVGWVTDTYGA 403
>pir||T45097 hypothetical protein [imported] - Mycobacterium smegmatis
>gi|2073532|gb|AAC45274.1| (U46844) orf4; putative
transporter; Method: conceptual translation supplied by
author [Mycobacterium smegmatis]
Length = 412
Score = 81.1 bits (197), Expect = 2e-14
Identities = 83/407 (20%), Positives = 174/407 (42%), Gaps = 23/407 (5%)
Query: 3 RNFWLFVAGRFISQLGWAIQEVALPLYVLDVTHSAKIMTLFVLADLIPSIITTPIAGVFG 62
R++ + G+ IS G +Q++ VL++T S ++ + V +P+++ T +AGV
Sbjct: 19 RDYRRYALGQTISVSGTWMQKLTQAWLVLELTDSPLLLGVTVAGQQLPTLLFTTLAGVLA 78
Query: 63 DRYDRKKIMVGFDL---IRGVLLFLVIAFNFLTIRCLLVVQVIMAIMNAFFSAGTGAMYP 119
DRY ++ I++ L + ++L +++ + + I +L V +A
Sbjct: 79 DRYSKRTILLWTALGGMLPALVLGVLVWIDVVNIWIVLAAAVAQGFADAVDKPARLTFVN 138
Query: 120 DLVKPEELERA---NSIVMSASIISRLVGPAIGGFVYGFGGIKLAILMNAISFFGSGLFE 176
D+ PE L A NSI+ ++ ++ GPA+ G + G+ + +NA S+ +
Sbjct: 139 DIATPETLANAVTLNSIIQNS---GKIAGPAVAGVLISAVGVSASFFLNAASYLPVVIAL 195
Query: 177 IFIKYEWKTRNIEGFSDFVRDIKEGLKFIMSNSFISTLIGLVILLNALGAPFASIIYPYA 236
+ I+ I G + E L+++ + I+ + L+ + L + +++ P
Sbjct: 196 LLIRPHAPV--ITGNVSAKGHLGETLRYVSARPHIAAALVLMAVSGLLAFNW-NVLLPTL 252
Query: 237 MREILKFSSQQFGLVESAFMLGALIGNLIVGAFLGAKAGRYIFRLFLVNGAVELIFILII 296
R+ ++ G ++ +GA+ G L + L + I ++ A+ L ++
Sbjct: 253 ARDTFGGDARVVGFAFTSMGVGAVFGGLALAGVLRGTSKWLILNGCVLGAALALTGLM-- 310
Query: 297 SPFLALPRNSAFMLLLVLGATMGMAGAMINVPLASKLQRAVPSEIRGRVFSTMEMLARIA 356
P + + A+ LL V+GA A + LQ +RGR+ S + +
Sbjct: 311 -PTVTI----AYALLFVVGA----ASVTFRSTATTLLQLYSDPGVRGRIISLLVLATNGT 361
Query: 357 NPLSLVVVGPLVDTIGAWKTASFLWLGSGVVILYYWIFKGKELTSEE 403
P+ ++G + LG+ L +W + K T ++
Sbjct: 362 TPVGGPMIGWICTHANPRVACLVGGLGTVAAALAHWAYLRKAGTRKD 408
>dbj|BAA03770.2| (D16251) ORF4; ORF4 has several potential initiation codons
[Escherichia coli]
Length = 388
Score = 80.4 bits (195), Expect = 4e-14
Identities = 83/354 (23%), Positives = 154/354 (43%), Gaps = 17/354 (4%)
Query: 24 VALPLYVLDVTHSAKIMTLFVLADLIPSIITTPIAGVFGDRYDRKKIMVGFDLIRGVLLF 83
+ALP +VL T SA + +I +II + G DR+ R + + ++ GV +
Sbjct: 4 LALPWFVLSHTKSAAWAGATAASSVIATIIGAWVGGGLVDRFGRAPVALISGVVGGVAMA 63
Query: 84 ---LVIAFNFLTIRCLLVVQVIMAIMNAFFSAGTGAMYPDL--VKPEELERANSIVMSAS 138
L+ A L+ L+ V+ A +A A + P L V +ER +S+
Sbjct: 64 SIPLLDAVGALSNTGLIACVVLGAAFDAPGMAAQDSELPKLGHVAGLSVERVSSLKAVIG 123
Query: 139 IISRLVGPAIGGFVYGFGGIKLAILMNAISFFGSGLFEIFIKYEWKTRNIEGFSDFVRDI 198
++ L GPA+GG G G + + A +GL ++ R + + +
Sbjct: 124 NVAILGGPALGGAAIGLLGAAPTLGLTAFCSVLAGLLGAWVLPARAARTMTTTATL--SM 181
Query: 199 KEGLKFIMSNSFISTLIGLVILLNALGAPFASIIYPYAMREILKFSSQQFGLVESAFMLG 258
+ G+ F+ S + L G+V++ + S+I P + + + GL S G
Sbjct: 182 RAGVAFLWSEPLLRPLFGIVMIFVGIVGANGSVIMPALFVDAGR-QVAELGLFSSMMGAG 240
Query: 259 ALIGNLIVGAFLGAKAGRYIFRLFLVNGAVELIFILIISPFLALPRNSAFMLLLVLGATM 318
L+G + + A +GA+ + G+ + L++S +P +L++LGA +
Sbjct: 241 GLLG-IAIHASVGARISAQNWLAVAFCGSA--VGSLLLSQLPGVP------VLMLLGALV 291
Query: 319 GMAGAMINVPLASKLQRAVPSEIRGRVFSTMEMLARIANPLSLVVVGPLVDTIG 372
G+ ++ L + + P E+ GRV T+ + A+P+ ++ G VD G
Sbjct: 292 GLLTGSVSPILNAAIYNRTPPELLGRVLGTVSAVMLSASPMVMLAAGAFVDLAG 345
>sp|P39642|YWFF_BACSU HYPOTHETICAL 43.4 KD PROTEIN IN ROCC-PTA INTERGENIC REGION
>gi|629091|pir||S39739 efflux protein homolog ywfF -
Bacillus subtilis >gi|414008|emb|CAA51640.1| (X73124)
ipa-84d [Bacillus subtilis] >gi|2636306|emb|CAB15797.1|
(Z99123) alternate gene name: ipa-84d~similar to efflux
protein [Bacillus subtilis]
Length = 394
Score = 80.0 bits (194), Expect = 5e-14
Identities = 82/308 (26%), Positives = 137/308 (43%), Gaps = 32/308 (10%)
Query: 52 IITTPIAGVFGDRYDRKKIMVGFDLIRGVLLFLVIAFNFLTIRCLLVVQVIMAIMNA--F 109
++ P GV DR DR KIM+ D+IRG++ FL + F L+ + ++ + F
Sbjct: 53 MVFQPFLGVLVDRLDRIKIMLWTDIIRGII-FLGLTFLPKGEYPLIFLALLFITYGSGVF 111
Query: 110 FSAGTGAMYPDLVKPEELERANSIVMSASIISRLVGPAIGGFVYGFGGIKLAILMNAISF 169
F+ A+ L +++ N++ A+ IS +VG A GG G ++LA+ N +++
Sbjct: 112 FNPARLAVMSSL--ESDIKSINTLFAKATTISIIVGAAAGGLFLLGGSVELAVAFNGVTY 169
Query: 170 FGSGLFEIFIKYEWKTRNIEGFSDFVRDIKEGLKFIMSNSFISTLIGLVILLNALGAPFA 229
S F IK ++ E + + KEGLK I +NSF+ + +I + L
Sbjct: 170 LVSAFFISRIKLQFVPIQSENIKEAFQSFKEGLKEIKTNSFVLNAMFTMITMALLW---- 225
Query: 230 SIIYPYAMREILKFSSQQFGLVESAFMLGALIGNLIV------GAFLGAKAGRYIFRLFL 283
++Y Y F +V S F+ IGN I+ G F+GA + +
Sbjct: 226 GVVYSY------------FPIV-SRFLGDGEIGNFILTFCIGFGGFIGA---ALVSKWGF 269
Query: 284 VNGAVELIFILIISPFLALPRNSAFMLLLVLGATMGMAGAMINVPLAS-KLQRAVPSEIR 342
N F ++ LAL + + V+ A + LA K+Q ++I+
Sbjct: 270 NNNRGLTYFTVLSIVSLALFLFTPIFAVSVIAAILFFIAMEYGEVLAKVKVQENAANQIQ 329
Query: 343 GRVFSTME 350
GR+FS E
Sbjct: 330 GRIFSVAE 337
>pir||C83068 probable MFS transporter PA4622 [imported] - Pseudomonas aeruginosa
(strain PAO1) >gi|9950874|gb|AAG08010.1|AE004876_5
(AE004876) probable MFS transporter [Pseudomonas
aeruginosa]
Length = 403
Score = 80.0 bits (194), Expect = 5e-14
Identities = 91/363 (25%), Positives = 155/363 (42%), Gaps = 21/363 (5%)
Query: 2 NRNFWLFVAGRFISQLGWAIQEVALPLYVLDVTHSAKIMTLFVLADLIPSIITTPIAGVF 61
+R F F R + G+ + VA+ ++ ++T + + L L + +P ++ G
Sbjct: 11 HRPFLAFWLARVCTASGFQMLTVAIGWHIYELTGNVLDLGLVGLVEFLPRVLFMLHTGHV 70
Query: 62 GDRYDRKKI----MVGFDLIRGVLLFLVIAFNFLTIRCLLVVQVIMAIMNAFFSAGTGAM 117
DRYDR++I G L+ V L L A +T + V+ + AF T A+
Sbjct: 71 ADRYDRRRIAALCQAGQALV-AVALVLGAASGEITRNMIFVLAFALGTARAFEMPTTQAL 129
Query: 118 YPDLVKPEELERANSIVMSASIISRLVGPAIGGFVYGFGGIKLAILMNAISFFGSGLFEI 177
P+LV RA + SA + + PA+GG +Y FG + + + L
Sbjct: 130 LPNLVPAGLFPRAVAASASAMQAATIAAPALGGLLYAFGASWVYVPTATLYVLACVL--- 186
Query: 178 FIKYEWKTRNIEGFSDFVRDIKEGLKFIMSNSFISTLIGLVILLNALGAPFASIIYPYAM 237
+ + + + + + G++FI S I I L + LG A+ + P
Sbjct: 187 TLSLPVRNQPLTQGKATLDSLLAGIRFIRSRPDIFGAISLDLFAVLLGG--ATALLPVFA 244
Query: 238 REILKFSSQQFGLVESAFMLGALIGNLIVGAF-LGAKAGRYIFRLFLVNGAVELIFILII 296
++IL GL+ SA +GAL + + F + GR +F + G + F L
Sbjct: 245 KDILLTGPWGLGLLRSAPAVGALAMSFWLAHFSIERNVGRIMFLSVGIFGLATIAFGLSK 304
Query: 297 SPFLALPRNSAFMLLLVLGATMGMAGAMINVPLASKLQRAVPSEIRGRVFSTMEMLARIA 356
S +L+L +L+VLGA A + V + +Q P E+RGRV + + +
Sbjct: 305 SFWLSLG------VLVVLGA----ADMVSMVIRGAFVQLETPDEMRGRVSAVNGLFIGAS 354
Query: 357 NPL 359
N L
Sbjct: 355 NQL 357
>emb|CAB71252.1| (AL138598) putative integral membrane efflux protein. [Streptomyces
coelicolor A3(2)]
Length = 434
Score = 79.6 bits (193), Expect = 6e-14
Identities = 86/385 (22%), Positives = 160/385 (41%), Gaps = 32/385 (8%)
Query: 2 NRNFWLFVAGRFISQLGWAIQEVALPLYVLDVTHSAKIMTLFVLADLIPSIITTPIAGVF 61
+R+F LF A R +++LG + VAL +L + A + L + A GV
Sbjct: 16 SRDFALFFAARAVARLGDTMLPVALAAGLLQHGYGAGAVGLAMAATAAAFAGLVVFGGVL 75
Query: 62 GDRYDRKKIMVGFDLIRGVLLFLVIAFNF---LTIRCLLVVQVIMAIMNAFFSAGTGAMY 118
DR+ +K+M+G DL+R L A F + + + + + A F G +
Sbjct: 76 ADRFSTRKLMIGADLVRLGTQALAAALFFSGHVVLWQICAIGFANGVAGAVFQPGVASTV 135
Query: 119 PDLVKPEELERANSIVMSASIISRLVGPAIGGFVYGFGGIKLAILMNAISFFGSGLFEIF 178
P L +++ AN + A ++L GPA+ G + GF +A ++ S L +
Sbjct: 136 PRLA--SDVQGANGAIRVAESAAQLAGPAVAGLLVGFASPGGVFAAHATTYAVSALCLLL 193
Query: 179 IKYE-----WKTRNIEGFSDFVRDIKEGLKFIMSNSFISTLIGL-VILLNALGAPFASII 232
++ + + G F D+ +G + ++ ++ +I + + + A+ P ++
Sbjct: 194 LRLPPPAPGSRAVSGRGSKAFRADLVQGWREFLARRWLWNVIAVWCVYMIAVWGPTVPLV 253
Query: 233 YPYAMREILKFSSQQFGLVESAFMLGALIGNLIVGAFLGAKAGRYIFRLFLVNGAVELI- 291
A + + + +GLV SA G ++G L+ + L GA+ L+
Sbjct: 254 ---ATEVVGEHGPRAYGLVNSALGAGTVVGGLLALRLRPVR--------MLRAGAIALVG 302
Query: 292 ---FILIISPFLALPRNSAFMLLLVLGATMGMAGAMINVPLASKLQRAVPSEIRGRVFST 348
F + L +P +A V GA M G M A+ +Q VP ++ R+ +
Sbjct: 303 FAAFPASVGAGLGVPAMAAG--AAVAGAGMSFWGVM----WATSVQTQVPPDVLNRIHAY 356
Query: 349 MEMLARIANPLSLVVVGPLVDTIGA 373
+ P+ + GP +GA
Sbjct: 357 DVAGSLAMMPVGQALAGPAAAALGA 381
>dbj|BAA36682.1| (AB016427) transmembrane protein [Bacillus licheniformis]
Length = 421
Score = 79.2 bits (192), Expect = 8e-14
Identities = 91/414 (21%), Positives = 173/414 (40%), Gaps = 29/414 (7%)
Query: 2 NRNFWLFVAGRFISQLGWAIQEVALPLYVLD-VTHSAKIMTLFVLADLIPSIITTPIAGV 60
N+N+ L F SQ+G I AL Y+LD ++ T+ L +P++ + GV
Sbjct: 10 NKNYALLFFASFTSQMGGIIGLTALLFYLLDRFSNQPAYATMTELMLSLPTLAVFFLVGV 69
Query: 61 FGDRYDRKKIMVGFDLI-RGVLLFLVIAFNFLTIRCLLVVQVIMAIMNAFFSAGTGAMYP 119
F D++DR+KI D I G+ + L+++ + V + + +FF+ ++
Sbjct: 70 FADKFDRQKIAKNCDWICMGLSIVLLLSLYLEWMPFTFAVLFLRNAVKSFFTPAQTSLIQ 129
Query: 120 DLVKPEELERANSIVMSASIISRLVGPAIGGFVYGFGGIKLAILMNAISFFGSGLFEIFI 179
++ E A + + + L G +G F Y G++ A++++A SF SGL
Sbjct: 130 GILSENEYSLAVGLNQMVASLFMLFGNGLGVFCYWTLGVEGAVMVDAASFALSGLLIQAC 189
Query: 180 KYEWKTRNIEG--------FSDFVRDIKEGLKFIMSNSFISTLIGLVILLNALGAPFASI 231
+ R G + +D G +I+++ + L+ +L + S+
Sbjct: 190 RISDAVRMPNGKHSIRQLNIAGIWKDFTLGFTYILNHKLLLALVSGFVLFGVVNGGL-SV 248
Query: 232 IYPYAMREILKFSSQQFGLVESAFMLGALIGNLIVGAFLGAKAGRYIFRLFLVNGAVELI 291
+ + ILK+ E + +LG + G + + A +L+ + LI
Sbjct: 249 MQVF----ILKYKLAPGNYEEMSIVLGIVFGAGFLAGSIAASLLSQKLKLYQL-----LI 299
Query: 292 FILIISPFLALPRN--SAFMLLLVLGATMGMAGAMINVPLASKLQRAVPSEIRGRVFSTM 349
LI+ + + + L +V + ++ INV + + V ++ GRV +
Sbjct: 300 LALIVCGCATISGSLVKSLWLYMVCSCFIAVSLPSINVAIGGWIPSIVNPKMMGRVQGWI 359
Query: 350 EMLARIANPLSLVVVGPLVDTIGAW-KTASFLWLGSGVVI---LYYWIFKGKEL 399
L ++ L+L+ + L AW S WL G +I ++Y I K L
Sbjct: 360 HPLMMLSQSLTLLFIAWLYP---AWIALESLYWLVGGSLIAVGVFYMIILPKFL 410
>pir||A82737 probable transport protein XF0993 [similarity] - Xylella fastidiosa
(strain 9a5c) >gi|9105927|gb|AAF83803.1|AE003937_7
(AE003937) drug:proton antiporter [Xylella fastidiosa]
Length = 418
Score = 78.8 bits (191), Expect = 1e-13
Identities = 84/381 (22%), Positives = 161/381 (42%), Gaps = 29/381 (7%)
Query: 5 FWLFVAGRFISQLGWAIQEVALPLYVLDVTHSAKIMTLFVLADLIPSIITTPIAGVFGDR 64
F +A R + L + I V + ++ ++T + ++ L LA+++P P AG D
Sbjct: 20 FTAVLAYRIAATLSYQIVSVTIGWHIYEITRNPLLLGLVALAEILPFFCIAPFAGYLVDH 79
Query: 65 YDRKKI--MVGFDLIRGVLLFLVIAFNFLTIRC-------LLVVQVIMAIMNAFFSAGTG 115
R+++ L + L+ AFN + + V + ++ +F
Sbjct: 80 LPRRRLGMFASLGLAMTPTILLIAAFNTAPVTAPVQTTWPIYVAASLSGMVRSFIVPVYN 139
Query: 116 AMYPDLVKPEELERA---NSIVMSASIISRLVGPAIGGFVYGFGGIKLAILMNAISFFGS 172
A++ ++ E+ R ++V AS++ + P +GG + GG LA ++ +
Sbjct: 140 ALFARVLAREDYARGAGLGTVVFQASLV---LSPMLGGILIALGGKGLAYAAGVVASIIA 196
Query: 173 GLFEIFIKYEWKTRNIEGFSDFVRDIKEGLKFIMSNSFISTLIGLVILLNALGAPFASII 232
L ++ E + + + + I EGL+F+ SN + + L + LG A +
Sbjct: 197 LLALALLRVEEPAVD-KPRAPVLGSIAEGLRFVFSNQIMLGAMALDMFSVLLGG--AVSM 253
Query: 233 YPYAMREILKFSSQQFGLVESAFMLGALIGNLIVGAF-LGAKAGRYIFRLFLVNGAVELI 291
P +++I + + G++ LG+++ L + + L AGR + G +
Sbjct: 254 LPAFIQDIFHYGPEGLGILRGTPALGSVLAGLWLARYPLQRHAGRTLLLAVAGFGICTIA 313
Query: 292 FILIISPFLALPRNSAFMLLLVLGATMGMAGAMINVPLASKLQRAVPSEIRGRVFSTMEM 351
F L +++ +LLV GA G++ + AS LQ P E+RGRV S +
Sbjct: 314 FGLSQHFWVSAG------ILLVYGACDGISVVL----RASILQLVTPDEMRGRVSSINSI 363
Query: 352 LARIANPLSLVVVGPLVDTIG 372
+N L G + IG
Sbjct: 364 FIGSSNELGAFYDGVMARFIG 384
>pir||T36090 probable integral membrane efflux protein - Streptomyces coelicolor
>gi|4678633|emb|CAB41206.1| (AL049661) putative integral
membrane efflux protein [Streptomyces coelicolor A3(2)]
Length = 500
Score = 77.6 bits (188), Expect = 2e-13
Identities = 88/379 (23%), Positives = 156/379 (40%), Gaps = 28/379 (7%)
Query: 4 NFWLFVAGRFISQLGWAIQEVALPLYVLDVTHSAKIMTLFVLADLIPSIITTPIAGVFGD 63
N+ LF G+ +S G Q +A VL +T S+ + + +P ++ GV D
Sbjct: 85 NYRLFFLGQVVSNNGTWTQRIAQDWLVLSLTGSSTAVGITTALQFLPLLLFGLYGGVLVD 144
Query: 64 RYDRKKIMVGFDLIRGVLLFLVIAFNFLTIRCLLVVQVIMAIMNAFFSAGTGAMYP---- 119
R ++ I++ + L L +A LT R ++ + A F+ G +
Sbjct: 145 RLPKRPILLATQVAMA-LTALALAVLTLTGRVH-----VLHVYAAAFAVGLATVLDNPAR 198
Query: 120 -----DLVKPEELERANSIVMSASIISRLVGPAIGGFVYGFGGIKLAILMNAISFFGSGL 174
+LV PE L A + + +RL+GPA+ G + G A L+N +SF + L
Sbjct: 199 QSFLSELVGPELLRNAVGLNSANFQSARLIGPALAGLLITGVGTGWAFLLNGVSF-AAPL 257
Query: 175 FEIFIKYEWKTRNIEGFSDFVRDIKEGLKFIMSNSFISTLIGLVILLNALGAPFASIIYP 234
+ + + +E ++EGL+++ + I LV F +
Sbjct: 258 ACMLLMRSRELHAVERAPRGKGQLREGLRYVAGRPDLVWPIVLVGFFGTFALNFPVHLSA 317
Query: 235 YAMREILKFSSQQFGLVESAFMLGALIGNLIVGAFLGAKAGRYIFRLFLVNGAVELIFIL 294
+A ++ + + L + G+L G L+ + R F L G ++ + +
Sbjct: 318 FA-DDVFDAGAGAYSLFNTLVAAGSLTGALLAARHEATRR-RLPFLAALAFGVLQAVAAV 375
Query: 295 IISPFLALPRNSAFMLLLVLGATMGMAGAMINVPLASKLQRAVPSEIRGRVFSTMEMLAR 354
P +F LL+V MG+ ++NV + +Q + +RGRV + M+
Sbjct: 376 A-------PTLWSFALLMV---PMGLFAMVVNVTTNATMQTSTAPAVRGRVTALYMMVLL 425
Query: 355 IANPLSLVVVGPLVDTIGA 373
PL VVG + DT GA
Sbjct: 426 GGAPLGAPVVGWITDTYGA 444
>pir||A81752 conserved hypothetical protein TC0009 [imported] - Chlamydia
muridarum (strain Nigg) >gi|7190049|gb|AAF38902.1|
(AE002269) conserved hypothetical protein [Chlamydia
muridarum]
Length = 559
Score = 77.6 bits (188), Expect = 2e-13
Identities = 92/411 (22%), Positives = 185/411 (44%), Gaps = 31/411 (7%)
Query: 3 RNFWLFVAGRFISQLGWAIQEVALPLYVLD---VTHSAKIMTLFVLADLIPSIITTPIAG 59
R+F V F++ + + + L +L+ + +AKI++L +P I+ P +G
Sbjct: 8 RSFQALVVTHFLTIINDNLYKFLLVFSLLEGKTLEENAKILSLVSFFFALPYILLAPFSG 67
Query: 60 VFGDRYDRKKIMVGFDLIRGVLLFL-VIAFNFLTIRCLL---VVQVIMAIMNAFFSAGTG 115
DR+ ++ I++ L R +F ++ F I +L +V V+MA +A F
Sbjct: 68 SLADRFQKRNIIL---LTRVAEIFCAILGVYFFHIHSVLGGYLVLVLMACHSAIFGPAKM 124
Query: 116 AMYPDLVKPEELERANSIVMSASIISRLVGPAIGGFVYGFGGIKLAILMNAISFFG--SG 173
+ P+++ EEL +AN + +A+ ++G + + +A ++F S
Sbjct: 125 GILPEMLPIEELSKANGAMTAATYSGSILGSCLAPLMVDLTQDFIANSYELSAWFCVISS 184
Query: 174 LFEIFIKYEWKTRNIEGFSDFV-----RDIKEGLKFIMSNSFISTLIGLVILLNALGAPF 228
+ +FI + + N++ + +++ K + ++++T + LV +GA
Sbjct: 185 ILSLFIAFRIRASNVKNKQQKIAYVSFKNLWGVFKETRNIAYLTTSVFLVAFFLFVGAYV 244
Query: 229 ASIIYPYAMREILKFSSQQFGLVESAFMLGALIGNLIVGAFL-GAKAGRYIFRLFLVNGA 287
I P+ E S+ +G A++ + + VG+++ G +G+ I F A
Sbjct: 245 QLQIIPFV--EFTLGYSKHYG----AYLFPIVAVGMGVGSYMAGWVSGKDIKLGFSPLAA 298
Query: 288 VELIFILIISPFLALPRNSAFMLLLVLGATMGMAGAMINVPLASKLQRAVPSEIRGRVFS 347
V + F +++ L +S+ +L+L +G+ G + VPL + +Q P RG+V +
Sbjct: 299 VGVGFSMMVLCLL----SSSIAAVLILLFCLGLFGGIYQVPLHAYIQFVSPEHKRGQVLA 354
Query: 348 TMEMLARIANPLSLVVVGPLVDTIGAWKTASFLWLGSGVV---ILYYWIFK 395
L L+ V L + SFL++GS V+ +L W+FK
Sbjct: 355 LNNFLDFSGVLLAAGFVRLLGSGLRLTPDQSFLYMGSLVMCLAVLSLWLFK 405
>pir||A83308 probable MFS transporter PA2701 [imported] - Pseudomonas aeruginosa
(strain PAO1) >gi|9948775|gb|AAG06089.1|AE004698_5
(AE004698) probable MFS transporter [Pseudomonas
aeruginosa]
Length = 529
Score = 77.3 bits (187), Expect = 3e-13
Identities = 86/351 (24%), Positives = 152/351 (42%), Gaps = 27/351 (7%)
Query: 6 WLFVAGRFISQLGWAIQEVALPLYVLDVTHSAKIMTLFVLADLIPSIITTPIAGVFGDRY 65
WL++A S +G + EV + ++ S + L +A +P AG D
Sbjct: 19 WLWLAS-IASNIGTWMHEVGAGWLMTSLSASPLNVALVQVAGSLPMFFLALPAGALADIV 77
Query: 66 DRKKIMVGFDLIRGVLLFLVIAFNFL---TIRCLLVVQVIMAIMNAFFSAGTGAMYPDLV 122
D+++ ++G L ++ L+ + L ++ LL + + M I A A P+LV
Sbjct: 78 DKRRYLLGVQLWMALVATLLASLTLLQLTSVWLLLGLTLCMGIGTALMMPAWSATTPELV 137
Query: 123 KPEELERANSIVMSASIISRLVGPAIGGFVYGFGGIKLAILMNAISFFGSGLFEIFIKYE 182
+EL A ++ ++R VGPAI G + G L +NA+SFF I +
Sbjct: 138 GKDELPAAVALSSVGVNLARAVGPAIAGVLVSLVGPWLTFALNALSFFA----VIAVLLA 193
Query: 183 WKTRNIEGFSDFVR---DIKEGLKFIMSNSFISTLIGLVILLNALGAPFASIIYPYAMRE 239
WK + R ++ G ++ S+ + +++ + LGA + P +R
Sbjct: 194 WKREAVPSVLPAERLFGALRAGWRYSRSSRPLQSVLVRAVAF-FLGASAGMSLLPLIVRG 252
Query: 240 ILKFSSQQFGLVESAFMLGALIGNLIVGAFLGAKAGRYIFRLFLVNGAVELIFILIISPF 299
L ++ FGL L+G++ VGA LGA ++ RL G+ L+ + +
Sbjct: 253 ELHGNAMDFGL---------LLGSVGVGAVLGA---AFLPRLRERLGSDRLVLLSSVLYA 300
Query: 300 LALPRNSAFMLLLVLGATMGMAGAMINVPLAS---KLQRAVPSEIRGRVFS 347
L L + L +L M ++GA L+S Q +VP+ +R R +
Sbjct: 301 LVLVALALLRNLYLLVPVMLLSGAAWIAVLSSLQVAAQTSVPAWVRARALA 351
>emb|CAB92212.1| (AL356592) putative transmembrane transport protein. [Streptomyces
coelicolor A3(2)]
Length = 437
Score = 76.1 bits (184), Expect = 7e-13
Identities = 86/376 (22%), Positives = 151/376 (39%), Gaps = 21/376 (5%)
Query: 6 WLFVAGRFISQLGWAIQEVALPLYVLDVTHSAKIMTLFVLADLIPSIITTPIAGVFGDRY 65
W VA F+S G +Q L VL +T SA L + P+++ + G DR+
Sbjct: 34 WWSVAN-FVSNAGTWMQLTVQNLLVLQITGSAAATGLSMSVQAAPALLISVFGGAAVDRW 92
Query: 66 DRKKIMVGFDLIRGVLLF---LVIAFNFLTIRCLLVVQVIMAIMNAFFSAGTGAMYPDLV 122
RK + G + F L++A + L + L+V+ + ++ + DLV
Sbjct: 93 PRKLTAAVSQALLGAVAFVTALMVALDRLDMGSLMVLAAVTGVIATVDGPACSLLGNDLV 152
Query: 123 KPEELERANSIVMSASIISRLVGPAIGGFVYGFGGIKLAILMNAISF-FGSGLFEIFIKY 181
E++ A + RL G A+ G GF G A N +SF F + +
Sbjct: 153 PREDVPSAIGVGALVHQAGRLTGAALAGVTVGFLGTAAAYAANGLSFLFVASVIPFLRPA 212
Query: 182 EWKTRNI----EGFSDFVRDIKEGLKFIMSNSFISTLIGLVILLNALGAPFASIIYPYAM 237
R+ E + ++EGL F + L G+ + G + + +
Sbjct: 213 RGAIRHAGAAEERGAQDTMSVREGLTFFARRPRLLALAGVTGVSAVFGRNY-QLTLAVLV 271
Query: 238 REILKFSSQQFGLVESAFMLGALIGNLIVGAFLGAKAGRYIFRLFLVNGAVELIFILIIS 297
L + FG V + +G ++G ++GA L + R + L G ++++ L S
Sbjct: 272 TGPLAGGAGSFGTVSTVLAVGGIVG-AVLGARLRRPSVRVVGALAAAGGLLQVVAGL--S 328
Query: 298 PFLALPRNSAFMLLLVLGATMGMAGAMINVPLASKLQRAVPSEIRGRVFSTMEMLARIAN 357
P LA +LLV+ M + ++ + + LQ P+ +RGRV + +
Sbjct: 329 PSLA--------VLLVMVLPMAVVESVSDTAGTAVLQTDPPAHMRGRVLGVWGSIGTVWG 380
Query: 358 PLSLVVVGPLVDTIGA 373
+G L++ GA
Sbjct: 381 LGGPPALGLLMELAGA 396
>gb|AAD45543.1|U70376_8 (U70376) SpcT [Streptomyces flavopersicus]
Length = 433
Score = 75.7 bits (183), Expect = 9e-13
Identities = 92/391 (23%), Positives = 165/391 (41%), Gaps = 23/391 (5%)
Query: 7 LFVAGRFISQLGWAIQEVALPLY-VLDVTHSAKIMTLFVLADLIPSIITTPIAGVFGDRY 65
LF+ +++ G A V LPL VL + A L P ++ AG +R
Sbjct: 30 LFLGSHALNETGAAATLVVLPLTAVLSLDAQAWQTALIQTFHFAPYLVFGLPAGAVVERL 89
Query: 66 DRKKIMVGFDLIRGVLLF---LVIAFNFLTIRCLLVVQVIMAIMNAFFSAGTGAMYPDLV 122
+++M+G DL+R V L + A N L++ L V +++ F + P L+
Sbjct: 90 RPRRVMIGADLLRFVALMSLPVAWALNALSLPHLYAVALLLGGAQLFGDIADQSYLPHLL 149
Query: 123 KPEELERANSIVMSASIISRLVGPAIGGFVYGFGGIKLAILMNAISFFGSGLFEIFIKYE 182
+ L + NS + + L GP IGG + G LA+ +N ++ S L I
Sbjct: 150 VKDRLFQGNSNLQMIRATAELGGPGIGGVAVQWLGTHLAVAVNGLASALSALLLWRIPVP 209
Query: 183 WKTRNIEGFSDFVRDIKEGLKFIMSNSFISTLIGLVILLNALGAPFASIIYPYAMREILK 242
+ VR G+ ++ + V+ L AL A ++I A+ +
Sbjct: 210 -DAQPAAPSHGLVRQTWHGISVLLRHP--------VLRLLALSASLNNLILSAALALDVV 260
Query: 243 FSSQQFGLVESAFMLGALIGNLIVGAFLGAKAGRYIFRLFLVNGAVELIFILIISPF--- 299
F +Q G+ +A ++G L+ VGA +GA + R L +G ++ + + +PF
Sbjct: 261 FLNQVVGV--TAGLVGFLLAAGAVGALIGAWLAPRLTRA-LGSGRTAVLAVPVAAPFMFL 317
Query: 300 LALPRNSAFMLLLVLG-ATMGMAGAMINVPLASKLQRAVPSEIRGRVFSTMEMLARIANP 358
+ L + + L LG + + + N+ + Q+ P E+ R+ + A P
Sbjct: 318 IPLTGDGWRVALFALGHIAISIGITVFNIMQVTYRQQVCPPELLSRMAAMFRWAVWGAAP 377
Query: 359 LSLVVVGPLVDTIGAWKTASFLWLGSGVVIL 389
L G L ++G T LW+ +G +++
Sbjct: 378 LGATAGGALAASVGVRDT---LWILAGALMV 405
>gi|10954847 Hypothetical gene [Agrobacterium tumefaciens]
>gi|6498200|dbj|BAA87652.1| (AB016260) Hypothetical gene
[Agrobacterium tumefaciens]
Length = 405
Score = 73.4 bits (177), Expect = 5e-12
Identities = 86/363 (23%), Positives = 147/363 (39%), Gaps = 23/363 (6%)
Query: 14 ISQLGWAIQEVALPLYVLDVTHSAKIMTLFVLADLIPSIITTPIAGVFGDRYDRKKIMVG 73
+S+L + + L L+VL S + A ++P ++ +PIAGV DR I V
Sbjct: 25 LSRLAGRMFILTLVLFVLARFSSPALAGWLTFAAIVPGLMVSPIAGVLLDRVG-PTIAVR 83
Query: 74 FDLIRGVLLFLVIA----FNFLTIRCLLVVQVIMAIMNAFFSAGTGAMYPDLVKPEELER 129
D+I + I+ N+ T L + ++ ++ +AGT + P LV L+R
Sbjct: 84 IDMIASAIFIAAISTVSWLNWTTPPVLFFLVILFSLAGPLGAAGTRTLLPRLVPSHALDR 143
Query: 130 ANSIVMSASIISRLVGPAIGGFVYGFGGIKLAILMNAISFFGSGLFEIFIKYEWKTRNIE 189
AN++ + + +VGPA+ G + + G + A+ M A+ + G+ + +
Sbjct: 144 ANALDTAVYAVVDVVGPAMAGIIVAWLGPESAMSMIALFYAGAAICMSLVPL--LPGLAS 201
Query: 190 GFSDFVRDIKEGLKFIMSNSFISTLIGLVILLN----ALGAPFASIIYPYAMREILKFSS 245
G + F+R EG++ + TL GL I + G + + A S
Sbjct: 202 GQASFMRQTLEGIQIVARQ---PTLRGLAISYSMYQITWGVLYVVVPVFVANHYDTSIGS 258
Query: 246 QQFGLVESAFMLGALIGNLIVGAFLGAKAGRYIFRLFLVNGAVELIFILIISPFLALPRN 305
G + +A + IG L G R+I + +V I L P A
Sbjct: 259 SVTGFLWAAMGIAGGIGALFAGHIRTTGRERHIMAIGMV------ITALAAWPVAAEFGF 312
Query: 306 SAFMLLLVLGATMGMAGAMINVPLASKLQRAVPSEIRGRVFSTMEMLARIANPLSLVVVG 365
+ L+L G+ I+V L + QR + GRV S L PL + G
Sbjct: 313 GGLAIGLMLA---GVMSGPIDVALLTLRQRRTDPQQLGRVMSISMSLNLAGFPLGSALAG 369
Query: 366 PLV 368
++
Sbjct: 370 MVI 372
>gb|AAD50454.1|AF170704_4 (AF170704) SpcT [Streptomyces spectabilis]
Length = 430
Score = 73.0 bits (176), Expect = 6e-12
Identities = 91/383 (23%), Positives = 160/383 (41%), Gaps = 30/383 (7%)
Query: 3 RNFWLFVAGRFISQLGWAIQEVALPLY-VLDVTHSAKIMTLFVLADLIPSIITTPIAGVF 61
R F L V +++ G A V LPL VL + SA L A ++ AG
Sbjct: 24 RGFRLLVGSHLLNETGAAATLVVLPLTAVLALDASAWQTALIESAYFCAYLVLGLPAGAL 83
Query: 62 GDRYDRKKIMVGFDLIRGVLLF---LVIAFNFLTIRCLLVVQVIMAIMNAFFSAGTGAMY 118
+R +++M+G D +R V L L A + L++ + V +++ F +
Sbjct: 84 VERARPRRVMIGADAVRCVALASLPLAWAADGLSLPMVYAVALLLGCAQLFGDIADHSYL 143
Query: 119 PDLVKPEELERANSIVMSASIISRLVGPAIGGFVYGFGGIKLAILMNAISFFGSGLFEIF 178
P LV+ E+L + NS + + L GP +GG + G A+ NA+ GS + +
Sbjct: 144 PRLVREEQLVQGNSTLQLIRSGAELGGPGLGGLSVQWLGAYWALAANAV---GSAVSAVL 200
Query: 179 IKYEWKTRNIEG-----FSDFVRDIKEGLKFIMSNSFISTLIGLVILLNALGAPFASIIY 233
+ W+ + E R EGL F+ V+ + A+ A ++++
Sbjct: 201 L---WRIKVPEPEPPALAHGLARQTWEGLSFVRRQP--------VLRMLAVSASLNNLVF 249
Query: 234 PYAMREILKFSSQQFGLVESAFMLGALIGNLIVGAFLGAKAGRYIFRLFLVNGAVELIFI 293
A + F S+ G+ A ++G L+ + VGA GA + R F + + +
Sbjct: 250 SAAFALDVVFLSKVVGV--PAGLVGVLLASGAVGALAGAWLTPRLARRF-GDARTATLAV 306
Query: 294 LIISPFL---ALPRNSAFMLLLVLG-ATMGMAGAMINVPLASKLQRAVPSEIRGRVFSTM 349
+ +PFL L ++ +LL L + + + N+ + QR P+++ RV +
Sbjct: 307 PVAAPFLLLAPLTQDDWRVLLFALAHLAISVGVTVFNILQVTYRQRVCPADLLSRVSAIF 366
Query: 350 EMLARIANPLSLVVVGPLVDTIG 372
A PL + G L +G
Sbjct: 367 RFAVWGAAPLGALAGGALAAHLG 389
>pir||F72041 efflux protein - Chlamydophila pneumoniae (strain CWL029)
>gi|4377042|gb|AAD18875.1| (AE001655) Efflux Protein
[Chlamydophila pneumoniae CWL029]
>gi|8979108|dbj|BAA98943.1| (AP002547) efflux protein
[Chlamydophila pneumoniae J138]
Length = 565
Score = 72.6 bits (175), Expect = 8e-12
Identities = 86/404 (21%), Positives = 170/404 (41%), Gaps = 26/404 (6%)
Query: 3 RNFWLFVAGRFISQLGWAIQEVALPLYVLD---VTHSAKIMTLFVLADLIPSIITTPIAG 59
++F V F++ + + + L ++L+ +T +AKI++ +P ++ P+AG
Sbjct: 8 KSFRALVTTHFLTIINDNLYKFLLAFFLLEGKTLTENAKILSCVSFFFALPFLLLAPLAG 67
Query: 60 VFGDRYDRKKIMVGFDLIRGVLLFLVIAFNFLTIRCLL---VVQVIMAIMNAFFSAGTGA 116
DR+ ++ I++ I +L ++ F I+ ++ VV ++MA F
Sbjct: 68 SLADRFQKRNIILATRFIE--ILCTILGTYFFFIQSVVGGYVVLILMACHTTIFGPAKLG 125
Query: 117 MYPDLVKPEELERANSIVMSASIISRLVGPAIGGFVY------GFGGIKLAILMNAISFF 170
+ P+++ E+L +AN I+ +A+ ++G + + G LM I
Sbjct: 126 ILPEMLPSEQLSQANGIMTAATYTGSILGSCLAPLLVDVTHRLGVNSYVWPTLMCVIVSI 185
Query: 171 GSGLFEIFIKYEWKTRNIEGFSDFV--RDIKEGLKFIMSNSFISTLIGLVILLNALGAPF 228
S L I+ +N++ V +D+ + LK +++ I L +GA
Sbjct: 186 ISTLISFCIRPS-NVKNVKQKITLVSFKDLWKVLKDTRMIHYLTVSIFLGSFFLLIGAYT 244
Query: 229 ASIIYPYAMREILKFSSQQFGLVESAFMLGALIGNLIVGAFLGAKAGRYIFRLFLVNGAV 288
I P+ + LK+ + LG G+ I G +G+ I ++ A+
Sbjct: 245 QLEIIPF-VEFTLKYPKHYGAYLFPIVALGVGTGSYITGKI----SGKDIKIGYVPLAAI 299
Query: 289 ELIFILIISPFLALPRNSAFMLLLVLGATMGMAGAMINVPLASKLQRAVPSEIRGRVFST 348
L L+ A + F+L +L +G G + VPL + +Q A P RG++ +
Sbjct: 300 GLA--LVFMGLYAFACSILFVLFFLLA--LGFLGGVYQVPLHAYVQYASPEHKRGQILAA 355
Query: 349 MEMLARIANPLSLVVVGPLVDTIGAWKTASFLWLGSGVVILYYW 392
L ++ V+ L +G SF ++G V+ + W
Sbjct: 356 NNFLDFFGVLVAAGVIRVLGSNLGLSPETSFFYIGWFVLAVSIW 399
>pir||E81624 conserved hypothetical protein CP0009 [imported] - Chlamydophila
pneumoniae (strain AR39) >gi|7188947|gb|AAF37905.1|
(AE002164) conserved hypothetical protein [Chlamydophila
pneumoniae AR39]
Length = 569
Score = 72.6 bits (175), Expect = 8e-12
Identities = 86/404 (21%), Positives = 170/404 (41%), Gaps = 26/404 (6%)
Query: 3 RNFWLFVAGRFISQLGWAIQEVALPLYVLD---VTHSAKIMTLFVLADLIPSIITTPIAG 59
++F V F++ + + + L ++L+ +T +AKI++ +P ++ P+AG
Sbjct: 12 KSFRALVTTHFLTIINDNLYKFLLAFFLLEGKTLTENAKILSCVSFFFALPFLLLAPLAG 71
Query: 60 VFGDRYDRKKIMVGFDLIRGVLLFLVIAFNFLTIRCLL---VVQVIMAIMNAFFSAGTGA 116
DR+ ++ I++ I +L ++ F I+ ++ VV ++MA F
Sbjct: 72 SLADRFQKRNIILATRFIE--ILCTILGTYFFFIQSVVGGYVVLILMACHTTIFGPAKLG 129
Query: 117 MYPDLVKPEELERANSIVMSASIISRLVGPAIGGFVY------GFGGIKLAILMNAISFF 170
+ P+++ E+L +AN I+ +A+ ++G + + G LM I
Sbjct: 130 ILPEMLPSEQLSQANGIMTAATYTGSILGSCLAPLLVDVTHRLGVNSYVWPTLMCVIVSI 189
Query: 171 GSGLFEIFIKYEWKTRNIEGFSDFV--RDIKEGLKFIMSNSFISTLIGLVILLNALGAPF 228
S L I+ +N++ V +D+ + LK +++ I L +GA
Sbjct: 190 ISTLISFCIRPS-NVKNVKQKITLVSFKDLWKVLKDTRMIHYLTVSIFLGSFFLLIGAYT 248
Query: 229 ASIIYPYAMREILKFSSQQFGLVESAFMLGALIGNLIVGAFLGAKAGRYIFRLFLVNGAV 288
I P+ + LK+ + LG G+ I G +G+ I ++ A+
Sbjct: 249 QLEIIPF-VEFTLKYPKHYGAYLFPIVALGVGTGSYITGKI----SGKDIKIGYVPLAAI 303
Query: 289 ELIFILIISPFLALPRNSAFMLLLVLGATMGMAGAMINVPLASKLQRAVPSEIRGRVFST 348
L L+ A + F+L +L +G G + VPL + +Q A P RG++ +
Sbjct: 304 GLA--LVFMGLYAFACSILFVLFFLLA--LGFLGGVYQVPLHAYVQYASPEHKRGQILAA 359
Query: 349 MEMLARIANPLSLVVVGPLVDTIGAWKTASFLWLGSGVVILYYW 392
L ++ V+ L +G SF ++G V+ + W
Sbjct: 360 NNFLDFFGVLVAAGVIRVLGSNLGLSPETSFFYIGWFVLAVSIW 403
>gb|AAF63340.1|AF244574_3 (AF244574) export protein [Streptomyces spectabilis]
Length = 432
Score = 72.6 bits (175), Expect = 8e-12
Identities = 94/385 (24%), Positives = 159/385 (40%), Gaps = 30/385 (7%)
Query: 1 MNRNFWLFVAGRFISQLGWAIQEVALPLY-VLDVTHSAKIMTLFVLADLIPSIITTPIAG 59
+ R F L V +++ G A V LPL VL + SA L A ++ AG
Sbjct: 24 VRRGFRLLVGSHLLNETGAAATLVVLPLTAVLALDASAWQTALIESAYFSAYLVLGLPAG 83
Query: 60 VFGDRYDRKKIMVGFDLIRGVLLF---LVIAFNFLTIRCLLVVQVIMAIMNAFFSAGTGA 116
+R +++M+ D +R V L L A + L++ + VV +++ F +
Sbjct: 84 ALVERARPRRVMIVADAVRCVALASLPLAWAADGLSLPMVYVVALLLGCAQLFGDIADHS 143
Query: 117 MYPDLVKPEELERANSIVMSASIISRLVGPAIGGFVYGFGGIKLAILMNAISFFGSGLFE 176
P LV+ E+L + NS + + L GP IGG + G A+ NA+ GS +
Sbjct: 144 YLPRLVRDEQLVQGNSTLQLVRSGAELGGPGIGGLSVQWLGAYWALAANAV---GSAVSA 200
Query: 177 IFIKYEWKTRNIEG-----FSDFVRDIKEGLKFIMSNSFISTLIGLVILLNALGAPFASI 231
+ + W+ + E R EGL F+ + L A+ A ++
Sbjct: 201 VLL---WRIKVPEPEPPALAHGLARQTWEGLSFVRRQPVLRVL--------AVSASLNNL 249
Query: 232 IYPYAMREILKFSSQQFGLVESAFMLGALIGNLIVGAFLGAKAGRYIFRLFLVNGAVELI 291
++ A + F S+ G+ SA ++G L+ + VGA GA + R F + +
Sbjct: 250 VFSAAFALDVVFLSKVVGV--SAGLVGVLLASGAVGALAGAWLTPRLARRF-GDARTATL 306
Query: 292 FILIISPFL---ALPRNSAFMLLLVLG-ATMGMAGAMINVPLASKLQRAVPSEIRGRVFS 347
+ + +PFL L ++ +LL L + + + N+ + QR P + RV +
Sbjct: 307 AVPVAAPFLLLAPLTQDDWRVLLFALAHLAISVGVTVFNILQVTYRQRVCPVGMLSRVSA 366
Query: 348 TMEMLARIANPLSLVVVGPLVDTIG 372
A PL V G L +G
Sbjct: 367 IFRFAVWGAAPLGAVAGGALAAHLG 391
>emb|CAB62691.1| (AL133422) putative transmembrane efflux protein. [Streptomyces
coelicolor A3(2)]
Length = 427
Score = 71.8 bits (173), Expect = 1e-11
Identities = 90/400 (22%), Positives = 172/400 (42%), Gaps = 27/400 (6%)
Query: 1 MNRNFWLFVAGRFISQLGWAIQEVALPLYVLDVTHS--AKIMTLFVLADLIPSIITTPIA 58
+ R F +S G + A PL + V + A++ L + +++ P+
Sbjct: 20 LGRGFGWLWGAYTVSTFGTRLAFDAFPLIAVMVLDAGPARVAALSAAGLAVGAVVAVPL- 78
Query: 59 GVFGDRYDRKKIMVGFDLIRGVLLF---LVIAFNFLTIRCLLVVQVIMAIMNAFFSAGTG 115
G + + ++ +M+ DL+R +L L A L LLVV V++A + F A G
Sbjct: 79 GPWVEFRRKRPVMIATDLLRCAVLLSVPLAYALGRLGFAQLLVVSVVVAAADITFRAAAG 138
Query: 116 AMYPDLVKPEELERANSIVMSASIISRLVGPAIGGFVYGFGGIKLAILMNAISFFGSGL- 174
+ LV+ +L RAN + + + ++GP +GG G G + + +A+S+ S L
Sbjct: 139 SCLKALVRGPDLLRANGRFEATTWTAAMLGPPVGGAAIGLFGPVVTVAADAVSYLLSALG 198
Query: 175 FEIFIKYEWKTRNIEGFSDFVRDIKEGLKFIMSNSFISTLIGLVILLNAL---GAPFASI 231
E R D+ G ++++++ + L +L+N L AP ++
Sbjct: 199 IRAIGGGEPHPRRAAASRLRAGDLLNGWRYVLASPALRPLFLNTVLVNGLIMATAPLLAV 258
Query: 232 IYPYAMREILKFSSQQFGLVESAFMLGALIGNLIVGAFLGAKAGRYIFRLFLVNGAVELI 291
+ M L F+ Q+ L + LG L+G+ + G L A+ G + R+ + +G + +
Sbjct: 259 L----MLGDLGFAPWQYALAFAVPCLGGLVGSRMAGP-LVARFGEH--RVLVTSGVLRVC 311
Query: 292 FILIISPFLALPRNSAFMLLLVLGATMGMAGA--MINVPLASKLQRAVPSEIRGRVFSTM 349
+ + LA L+LV+ G+ + + N A++ P++ R S
Sbjct: 312 WPV----GLAFVGPGTGGLVLVMAVEFGLIASVGVYNPVYATRRLELTPADRVARTLSAW 367
Query: 350 EMLARIANPLSLVVVGPLVDTIGAWKTASFLWLGSGVVIL 389
+ ++ + G L G +TA L +GV++L
Sbjct: 368 TVSGKLTTAALTALWGLLAGLTGT-RTAVAL---AGVLLL 403
>sp|P39843|BMR2_BACSU MULTIDRUG RESISTANCE PROTEIN 2 (MULTIDRUG-EFFLUX TRANSPORTER 2)
>gi|2119909|pir||I39792 multidrug-efflux transporter blt
- Bacillus subtilis >gi|483941|gb|AAC36944.1| (L32599)
blt gene product [Bacillus subtilis]
>gi|1303699|dbj|BAA12355.1| (D84432) Blt [Bacillus
subtilis] >gi|2635104|emb|CAB14600.1| (Z99117)
multidrug-efflux transporter [Bacillus subtilis]
Length = 400
Score = 71.4 bits (172), Expect = 2e-11
Identities = 69/327 (21%), Positives = 141/327 (43%), Gaps = 41/327 (12%)
Query: 5 FWLFVAGRFISQLGWAIQEVALPLYVLDVTHSAKIMTLFVLADLIPSIITTPIAGVFGDR 64
F + ++ F++ LG + +P ++ + S M V A I +IT+P AG + DR
Sbjct: 12 FIILLSNIFVAFLGIGLIIPVMPSFMKIMHLSGSTMGYLVAAFAISQLITSPFAGRWVDR 71
Query: 65 YDRKKIMVGFDLIRGVLLFLVIAFNF---LTIRCLLVVQVIMAIMNAFFSAGTGAMYPDL 121
+ RKK+ +I G+L+F + F + +++ + AF A D+
Sbjct: 72 FGRKKM-----IILGLLIFSLSELIFGLGTHVSIFYFSRILGGVSAAFIMPAVTAYVADI 126
Query: 122 VKPEELERANSIVMSASIISRLVGPAIGGFVYGFGGIKLAILMNAISFFGSGLFEIFI-- 179
+E +A V +A ++GP GGF+ GF GI++ + + + +FI
Sbjct: 127 TTLKERSKAMGYVSAAISTGFIIGPGAGGFIAGF-GIRMPFFFASAIALIAAVTSVFILK 185
Query: 180 -------KYEWKTRNIEGFSDFVRDIKEGLKFIMSNSFISTLIGLVILLNALGAPFASII 232
+++ + E S+F++D+K + + +FI ++ + A G +
Sbjct: 186 ESLSIEERHQLSSHTKE--SNFIKDLKRSIHPVYFIAFI------IVFVMAFGLSAYETV 237
Query: 233 YPYAMREILKFSSQQFG--------LVESAFMLGALIGNLIVGAFLGAKAGRYIFRLFLV 284
+ FS +FG ++ + ++ +I L+ G + + + +L L+
Sbjct: 238 FSL-------FSDHKFGFTPKDIAAIITISSIVAVVIQVLLFGKLVNKLGEKRMIQLCLI 290
Query: 285 NGAVELIFILIISPFLALPRNSAFMLL 311
GA+ ++S FL + + F+ L
Sbjct: 291 TGAILAFVSTVMSGFLTVLLVTCFIFL 317
>pir||D71112 hypothetical protein PH0667 - Pyrococcus horikoshii
>gi|3257075|dbj|BAA29758.1| (AP000003) 413aa long
hypothetical protein [Pyrococcus horikoshii]
Length = 413
Score = 69.5 bits (167), Expect = 7e-11
Identities = 93/390 (23%), Positives = 165/390 (41%), Gaps = 43/390 (11%)
Query: 1 MNRNFWLFVAGRFISQLGWAIQEVALPLYVLDVTHSAKIMTLF-VLADLIPSIITTPIAG 59
+ RN F G F + L W I L +Y+ + + ++ L V+ +L +I P G
Sbjct: 27 LKRNITFFAIGMFFANLAWGIGYPYLTVYMKIIGGTMFLVGLLSVIYNLTSAIFQYPF-G 85
Query: 60 VFGDRYDRKK--IMVGFDLIRGVLLFLVIAFNFLTIRCLLVVQVIMAIMNAFFSAGTGAM 117
D+ ++K I++G L G LVI + T LL ++ + A F+ A+
Sbjct: 86 YLSDKIGKRKPFIILGV-LFSGTTYVLVIFIS--TPILLLSLRGTQGALGASFAPAHSAL 142
Query: 118 YPDLVKPEELERANSIVMSASIISRL---VGPAIGGFVYGFGGIKLAILMNAISFFGSGL 174
+L R S+ + + + VG +GG++ GIK A L +I S L
Sbjct: 143 ISELST-----RVGSMFGFFNFVENMGFMVGNFLGGYIVKKVGIKSAFLATSIVSLVSIL 197
Query: 175 FEIFIK-YEWKTRNIEGF--------SDFVRDIKEGLKFIMSNSFISTLIGLVILLNALG 225
F +K E K +NI F S+ V K +M + + +++ + A G
Sbjct: 198 FLTQVKERERKKKNIGSFLPIREGRESEKVEMKSSAFKMLMKGELGAFYLSVLLAMIASG 257
Query: 226 APFASIIYPYAMREILKFSSQQFGLVESAFMLGALIGNLIVGAFLGAKAGRYIFRLFLVN 285
+A++ P +E KF + G + L A +G+L++G + K G +F
Sbjct: 258 EVYATV--PVYFQE--KFGEEFVGFLLGIDSLAAALGSLLIGRLID-KYGEKVF------ 306
Query: 286 GAVELIFILIISPFLALPRNSAFMLLLVLGATMGMAGAMINVPLASKLQRAVPSEIRGR- 344
+L + I F+ + +++ ++ G+ AMI ++ + R VP RG+
Sbjct: 307 --YKLAILGYILTFIGYAWATTIIIMALVSLLSGVKWAMITSSASTYVARRVPHRERGQG 364
Query: 345 --VFSTMEMLARIANPLSLVVVGPLVDTIG 372
+ +TM L + PL + G + D G
Sbjct: 365 MGLLNTMMTLGWVIGPL---IGGLIADNFG 391
Database: ./suso.pep
Posted date: Jul 6, 2001 5:57 PM
Number of letters in database: 840,471
Number of sequences in database: 2977
Database: /banques/blast2/nr.pep
Posted date: Dec 14, 2000 12:46 PM
Number of letters in database: 188,266,275
Number of sequences in database: 595,510
Lambda K H
0.329 0.145 0.427
Gapped
Lambda K H
0.270 0.0470 0.230
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 141023248
Number of Sequences: 2977
Number of extensions: 5468530
Number of successful extensions: 19525
Number of sequences better than 1.0e-10: 50
Number of HSP's better than 0.0 without gapping: 5
Number of HSP's successfully gapped in prelim test: 45
Number of HSP's that attempted gapping in prelim test: 19393
Number of HSP's gapped (non-prelim): 57
length of query: 418
length of database: 189,106,746
effective HSP length: 53
effective length of query: 365
effective length of database: 157,386,935
effective search space: 57446231275
effective search space used: 57446231275
T: 11
A: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 40 (21.8 bits)
S2: 166 (69.1 bits)