BLASTP 2.0.10 [Aug-26-1999]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= PAB0764 (PAB0764) DE:HISTONE DEACETYLASE related
(334 letters)
Database: ./suso.pep; /banques/blast2/nr.pep
598,487 sequences; 189,106,746 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
pir||B75095 probable histone deacetylase (EC 3.5.1.-) PAB0764 - ... 692 0.0
pir||H71071 hypothetical protein PH1267 - Pyrococcus horikoshii ... 603 e-172
sp|Q57955|Y535_METJA HYPOTHETICAL PROTEIN MJ0535 >gi|2127738|pir... 305 5e-82
gb|AAK40374.1| Deacetylase, putative [Sulfolobus solfataricus] 229 5e-59
pir||G72762 probable acetylpolyamine aminohydrolase APE0092 - Ae... 211 9e-54
sp|O27262|YB94_METTH HYPOTHETICAL PROTEIN MTH1194 >gi|7430156|pi... 199 5e-50
pir||F72602 probable acetylpolyamine aminohydrolase APE1285 - Ae... 182 7e-45
gb|AAG18756.1| (AE004980) acetoin utilization protein; Aup [Halo... 169 5e-41
pir||A70481 acetoin utilization protein - Aquifex aeolicus >gi|2... 166 3e-40
gi|11497747 acetylpolyamine aminohydrolase (aphA) [Archaeoglobus... 166 5e-40
sp|P72702|Y245_SYNY3 HYPOTHETICAL 33.6 KD PROTEIN SLR0245 >gi|74... 163 3e-39
pir||T13964 probable histone deacetylase (EC 3.5.1.-) HDA2 - mouse 157 1e-37
gi|6996926 histone deacetylase 6; histone deacetylase 5 [Mus mus... 157 1e-37
gb|AAK40394.1| Acetylpolyamine aminohydrolase [Sulfolobus solfat... 152 8e-36
gb|AAF36540.1| (AF174499) GR AF-1 specific histone deacetylase [... 151 1e-35
gi|11420048 histone deacetylase 6 [Homo sapiens] >gi|4240291|dbj... 151 1e-35
gi|5174489 histone deacetylase 6 [Homo sapiens] >gi|10720024|sp|... 151 1e-35
pir||T46284 hypothetical protein DKFZp566E044.1 - human >gi|6808... 151 1e-35
dbj|BAB10370.1| (AB006696) contains similarity to histone deacet... 140 2e-32
pir||D83174 probable acetylpolyamine aminohydrolase PA3774 [impo... 136 3e-31
emb|CAB63048.1| (AL022328) dJ402G11.7 (novel protein similar to ... 135 6e-31
emb|CAB63049.1| (AL022328) dJ402G11.7 (novel protein similar to ... 135 6e-31
pir||T05998 hypothetical protein F17M5.230 - Arabidopsis thalian... 134 1e-30
gi|6324307 histone deacetylase, shares sequence similarity with ... 134 1e-30
sp|P56523|HDA1_SCHPO HISTONE DEACETYLASE CLR3 >gi|11359242|pir||... 132 4e-30
gb|AAD21090.1| (AF129433) histone deacetylase HDA2 [Drosophila m... 132 4e-30
sp|Q20296|YLFN_CAEEL HYPOTHETICAL 89.8 KD PROTEIN F41H10.6 IN CH... 131 2e-29
gb|AAD31553.1|U61954_9 (U61954) similar to bacillus subtilis ace... 131 2e-29
gb|AAD31554.1|U61954_10 (U61954) similar to bacillus subtilis ac... 131 2e-29
pir||T32425 hypothetical protein C10E2.3 - Caenorhabditis elegan... 127 1e-28
gb|AAF22892.1|AC006932_9 (AC006932) T27G7.14 [Arabidopsis thaliana] 127 2e-28
pir||T17245 hypothetical protein DKFZp586J0917.1 - human (fragme... 122 6e-27
gi|11436703 histone deacetylase 7 [Homo sapiens] 122 6e-27
dbj|BAA91545.1| (AK001190) unnamed protein product [Homo sapiens] 122 6e-27
dbj|BAB15759.1| (AK024469) FLJ00062 protein [Homo sapiens] 122 8e-27
gi|7705399 histone deacetylase 7A [Homo sapiens] >gi|7542540|gb|... 122 8e-27
gb|AAF31418.1|AF207748_1 (AF207748) histone deacetylase 5 [Mus m... 120 2e-26
gi|6996924 histone deacetylase 5; histone deacetylase 4 [Mus mus... 120 2e-26
gb|AAC18040.1| (AF039691) antigen NY-CO-9 [Homo sapiens] 120 3e-26
gi|9624996 histone deacetylase 7 [Mus musculus] >gi|6911184|gb|A... 120 3e-26
dbj|BAA25526.1| (AB011172) KIAA0600 protein [Homo sapiens] 119 4e-26
gi|4885531 histone deacetylase 5; KIAA0600 protein [Homo sapiens... 119 4e-26
pir||F81178 histone deacetylase family protein NMB0605 [imported... 119 4e-26
pir||A81926 hypothetical protein NMA0810 [imported] - Neisseria ... 118 9e-26
gi|5174481 histone deacetylase 4; histone deacetylase A; KIAA028... 116 4e-25
dbj|BAA22957.2| (AB006626) KIAA0288 protein [Homo sapiens] 116 4e-25
gi|11428734 histone deacetylase A [Homo sapiens] 116 4e-25
dbj|BAB06956.1| (AP001518) acetoin dehydrogenase [Bacillus halod... 115 1e-24
pir||T27101 hypothetical protein Y51H1A.5 - Caenorhabditis elega... 113 2e-24
gb|AAK41373.1| Acetoin utilization protein [Sulfolobus solfatari... 112 7e-24
sp|Q48935|APHA_MYCRA ACETYLPOLYAMINE AMINOHYDROLASE >gi|11360471... 107 2e-22
sp|P39067|ACUC_BACSU ACETOIN UTILIZATION ACUC PROTEIN >gi|628994... 107 2e-22
gb|AAF48245.1| (AE003492) CG1770 gene product [Drosophila melano... 106 4e-22
gb|AAG28403.1|AF193434_1 (AF193434) putative histone deacetylase... 104 2e-21
dbj|BAA91474.1| (AK001032) unnamed protein product [Homo sapiens] 102 6e-21
pir||B83605 probable acetylpolyamine aminohydrolase PA0321 [impo... 102 8e-21
sp|Q56195|ACUC_STAXY ACETOIN UTILIZATION ACUC PROTEIN >gi|117768... 101 1e-20
pir||H83469 acetylpolyamine aminohydrolase PA1409 [imported] - P... 98 2e-19
sp|O22446|HDAC_ARATH HISTONE DEACETYLASE (HD) >gi|2318131|gb|AAB... 96 6e-19
pir||T36278 hypothetical protein SCE68.28c - Streptomyces coelic... 96 6e-19
sp|P56521|HDAC_MAIZE PROBABLE HISTONE DEACETYLASE (RPD3 HOMOLOG)... 95 1e-18
pir||T05640 histone deacetylase (EC 3.5.1.-) F20D10.250 - Arabid... 95 1e-18
pir||T23963 hypothetical protein R06C1.1 - Caenorhabditis elegan... 92 1e-17
gi|6680195 histone deacetylase 2 [Mus musculus] >gi|3023934|sp|P... 91 2e-17
sp|P56517|HDA1_CHICK HISTONE DEACETYLASE 1 (HD1) >gi|2791684|gb|... 90 3e-17
gb|AAB99850.1| (AF043328) histone deacetylase 1 [Gallus gallus] 90 3e-17
gb|AAD10139.1| (AF045473) histone deacetylase [Zea mays] 90 3e-17
emb|CAA62950.1| (X91837) putative transcriptional regulator [Sac... 89 6e-17
sp|Q13547|HDA1_HUMAN HISTONE DEACETYLASE 1 (HD1) >gi|1277084|gb|... 89 6e-17
gi|6321244 (putative) histone deacetylase; Hos2p [Saccharomyces ... 89 6e-17
gi|4826756 histone deacetylase 1; RPD3 (reduced potassium depend... 89 6e-17
gi|6680193 histone deacetylase 1 [Mus musculus] >gi|2498444|sp|O... 89 6e-17
sp|O17695|HDA1_CAEEL PROBABLE HISTONE DEACETYLASE 1 >gi|7497847|... 89 6e-17
gb|AAB68398.1| (U80780) putative histone deacetylase [Mus musculus] 89 8e-17
sp|P56518|HDA1_STRPU HISTONE DEACETYLASE 1 (HD1) >gi|2654077|gb|... 89 8e-17
gb|AAC61494.1| (AF086715) putative histone deacetylase [Drosophi... 89 8e-17
gb|AAF47924.1| (AE003482) Rpd3 gene product [Drosophila melanoga... 89 8e-17
gb|AAG00980.1| (AF276431) histone deacetylase I [Tetrahymena the... 89 1e-16
sp|Q94517|HDAC_DROME PROBABLE HISTONE DEACETYLASE (HD) (DRPD3) >... 88 1e-16
gi|8923769 histone deacetylase 8 [Homo sapiens] >gi|11419830|ref... 88 1e-16
gi|4557641 histone deacetylase 2 [Homo sapiens] >gi|3023939|sp|Q... 88 2e-16
sp|O42227|HD12_XENLA PROBABLE HISTONE DEACETYLASE 1-2 (HD1) (RPD... 88 2e-16
dbj|BAB10553.1| (AB008265) histone deacetylase [Arabidopsis thal... 87 2e-16
sp|P56519|HDA2_CHICK HISTONE DEACETYLASE 2 (HD2) >gi|2791686|gb|... 87 4e-16
pir||T40300 histone deacetylase (EC 3.5.1.-) - fission yeast (S... 87 4e-16
pir||T22134 hypothetical protein F43G6.4 - Caenorhabditis elegan... 87 4e-16
gb|AAF82385.1| (AF282858) histone deacetylase [Mesembryanthemum ... 87 4e-16
gb|AAF73428.1|AF245664_1 (AF245664) histone deacetylase 8; HDAC8... 86 5e-16
gi|6323999 histone deacetylase; Rpd3p [Saccharomyces cerevisiae]... 85 9e-16
sp|O13298|PHD1_SCHPO PROBABLE HISTONE DEACETYLASE PHD1 >gi|74442... 85 9e-16
sp|P56520|HDA3_CHICK HISTONE DEACETYLASE 3 (HD3) >gi|2791688|gb|... 85 1e-15
pir||D70388 acetoin utilization protein - Aquifex aeolicus >gi|2... 85 1e-15
pdb|1C3P|A Chain A, Crystal Structure Of An Hdac Homolog From Aq... 85 1e-15
pdb|1C3R|A Chain A, Crystal Structure Of An Hdac Homolog Complex... 85 1e-15
gb|AAF28798.1|AF098295_1 (AF098295) histone deacetylase 3 [Mus m... 85 1e-15
gb|AAG28475.1|AF195548_1 (AF195548) putative histone deacetylase... 85 1e-15
sp|Q91695|HD11_XENLA PROBABLE HISTONE DEACETYLASE 1-1 (HD1) (MAT... 84 3e-15
gb|AAF36425.1|AF125536_1 (AF125536) histone deacetylase-3 [Mus m... 84 3e-15
gb|AAC23917.1| (AF026949) putative histone deacetylase HDAC1 [Dr... 83 3e-15
pir||JC7102 histone deacetylase (EC 3.5.1.-) - mouse >gi|3639054... 83 3e-15
gb|AAD22407.1|AF091326_1 (AF091326) histone deacetylase [Plasmod... 83 3e-15
gi|4504363 histone deacetylase 3 [Homo sapiens] >gi|7444257|pir|... 83 4e-15
gb|AAB88240.1| (U75696) RPD3-2A [Homo sapiens] 83 4e-15
gi|11416571 histone deacetylase 3 [Homo sapiens] >gi|3334210|sp|... 83 4e-15
gb|AAF52023.1| (AE003602) HDAC3 gene product [Drosophila melanog... 83 6e-15
gb|AAC83649.1| (AF071559) histone deacetylase dHDAC3 [Drosophila... 81 2e-14
gb|AAG21919.1|AF139991_1 (AF139991) histone deacetylase [Cryptos... 80 3e-14
gb|AAF80489.1|AF163862_1 (AF163862) histone deacetylase Rpd3A [A... 78 1e-13
sp|Q09440|HDA2_CAEEL PUTATIVE HISTONE DEACETYLASE C08B11.2 >gi|7... 77 3e-13
pir||T47443 hypothetical protein T18B22.80 - Arabidopsis thalian... 75 1e-12
gb|AAB87752.1| (AF005482) histone deacetylase-3C [Homo sapiens] 74 3e-12
gb|AAF80490.1|AF164342_1 (AF164342) histone deacetylase Hos2A [A... 73 5e-12
gb|AAC08351.1| (AF053139) histone deacetylase 3 [Homo sapiens] 73 6e-12
sp|P28606|YGLA_SYNP2 HYPOTHETICAL 34.1 KD PROTEIN IN GLNA 3'REGI... 71 1e-11
emb|CAA78368.1| (Z13965) Portion of hypothetical protein [Synech... 71 1e-11
emb|CAA78369.1| (Z13965) Portion of hypothetical protein [Synech... 71 1e-11
gi|6325325 Similar to Hda1p, Rpd3p, Hos2p, and Hos3p; Hos1p [Sac... 69 5e-11
emb|CAC14522.1| (AL446004) histone deacetylase 2 [Leishmania major] 69 9e-11
>pir||B75095 probable histone deacetylase (EC 3.5.1.-) PAB0764 - Pyrococcus
abyssi (strain Orsay) >gi|5458575|emb|CAB50063.1|
(AJ248286) HISTONE DEACETYLASE related [Pyrococcus
abyssi]
Length = 334
Score = 692 bits (1767), Expect = 0.0
Identities = 334/334 (100%), Positives = 334/334 (100%)
Query: 1 MIGEIYYSRKFLLHKPDNYHPENPGRLWLVLTAIRELGLENHVLEPSPIGEELIYRIHER 60
MIGEIYYSRKFLLHKPDNYHPENPGRLWLVLTAIRELGLENHVLEPSPIGEELIYRIHER
Sbjct: 1 MIGEIYYSRKFLLHKPDNYHPENPGRLWLVLTAIRELGLENHVLEPSPIGEELIYRIHER 60
Query: 61 EYVEKIRELSRRGGGYLDADTYVSPRTWEAAILALGASRLATLSALRYGGMNLALVRPPG 120
EYVEKIRELSRRGGGYLDADTYVSPRTWEAAILALGASRLATLSALRYGGMNLALVRPPG
Sbjct: 61 EYVEKIRELSRRGGGYLDADTYVSPRTWEAAILALGASRLATLSALRYGGMNLALVRPPG 120
Query: 121 HHAGRRGKALGAPTLGFCIFNNSAMAALTSKEETGKALVIDFDAHHGNGTQEIFWDDADV 180
HHAGRRGKALGAPTLGFCIFNNSAMAALTSKEETGKALVIDFDAHHGNGTQEIFWDDADV
Sbjct: 121 HHAGRRGKALGAPTLGFCIFNNSAMAALTSKEETGKALVIDFDAHHGNGTQEIFWDDADV 180
Query: 181 VHIDLHERDIYPGSGDVGEIGGINAKGSKINLPMPHYSEDGDYIYAWEEVVIPIVEEVKP 240
VHIDLHERDIYPGSGDVGEIGGINAKGSKINLPMPHYSEDGDYIYAWEEVVIPIVEEVKP
Sbjct: 181 VHIDLHERDIYPGSGDVGEIGGINAKGSKINLPMPHYSEDGDYIYAWEEVVIPIVEEVKP 240
Query: 241 KVVIVSAGFDGFKGDGLTTLKLTEVFYSYAGATLRKYPLAVILEGGYSSGLKKGFPAFIR 300
KVVIVSAGFDGFKGDGLTTLKLTEVFYSYAGATLRKYPLAVILEGGYSSGLKKGFPAFIR
Sbjct: 241 KVVIVSAGFDGFKGDGLTTLKLTEVFYSYAGATLRKYPLAVILEGGYSSGLKKGFPAFIR 300
Query: 301 GYEEDKVRDHAQPSYETLKLVEEVKDILSPWWSL 334
GYEEDKVRDHAQPSYETLKLVEEVKDILSPWWSL
Sbjct: 301 GYEEDKVRDHAQPSYETLKLVEEVKDILSPWWSL 334
>pir||H71071 hypothetical protein PH1267 - Pyrococcus horikoshii
>gi|3257687|dbj|BAA30370.1| (AP000005) 335aa long
hypothetical protein [Pyrococcus horikoshii]
Length = 335
Score = 603 bits (1538), Expect = e-172
Identities = 280/335 (83%), Positives = 309/335 (91%), Gaps = 1/335 (0%)
Query: 1 MIGEIYYSRKFLLHKPDNYHPENPGRLWLVLTAIRELGLENHVLEPSPIGEELIYRIHER 60
MIGEIYYSRKFLLHKP NYHPENPGRLW++LTAIRELGLEN ++EP PI E IY+IH+
Sbjct: 1 MIGEIYYSRKFLLHKPKNYHPENPGRLWIILTAIRELGLENQIVEPLPIDEAQIYKIHDP 60
Query: 61 EYVEKIRELSRRGGGYLDADTYVSPRTWEAAILALGASRLATLSALRYGGMNLALVRPPG 120
EYV++IR LS GGGYLDADTYV+ RTWE A+LALGASRLATLSAL YGG+N+ALVRPPG
Sbjct: 61 EYVKRIRGLSLNGGGYLDADTYVNQRTWEVAMLALGASRLATLSALEYGGLNMALVRPPG 120
Query: 121 HHAGRRGKALGAPTLGFCIFNNSAMAALTSKEETGKALVIDFDAHHGNGTQEIFWDDADV 180
HHAGRRG+ALGAPTLGFCIFNNSAMAALT KEETG+AL+IDFDAHHGNGTQEIFW+D +V
Sbjct: 121 HHAGRRGRALGAPTLGFCIFNNSAMAALTCKEETGEALIIDFDAHHGNGTQEIFWNDPEV 180
Query: 181 VHIDLHERDIYPGSGDVGEIGGINAKGSKINLPMPHYSEDGDYIYAWEEVVIPIVEEVKP 240
VH+DLHERDIYPGSGDV EIGG NA+GSKIN+PMPHYS+DGDYIYAW E+V+PIVE VKP
Sbjct: 181 VHVDLHERDIYPGSGDVNEIGGYNARGSKINIPMPHYSDDGDYIYAWNEIVLPIVERVKP 240
Query: 241 KVVIVSAGFDGFKGDGLTTLKLTEVFYSYAGATLRKYPLAVILEGGYSSGLKKGFPAFIR 300
KV+IVSAGFDGFKGDGLTTLKLTE+FYSYAG TLRKYPL +ILEGGYSSGLK+GFPAFI
Sbjct: 241 KVIIVSAGFDGFKGDGLTTLKLTEIFYSYAGVTLRKYPLVLILEGGYSSGLKRGFPAFIM 300
Query: 301 GYEEDKV-RDHAQPSYETLKLVEEVKDILSPWWSL 334
GYEEDK+ RD QPSYETLK+VEEVKDILSPWW L
Sbjct: 301 GYEEDKIKRDEGQPSYETLKVVEEVKDILSPWWPL 335
>sp|Q57955|Y535_METJA HYPOTHETICAL PROTEIN MJ0535 >gi|2127738|pir||G64366 acetylpolyamine
aminohydrolase - Methanococcus jannaschii
>gi|1591238|gb|AAB98526.1| (U67502) acetylpolyamine
aminohydrolase (aphA) [Methanococcus jannaschii]
Length = 343
Score = 305 bits (773), Expect = 5e-82
Identities = 160/334 (47%), Positives = 210/334 (61%), Gaps = 7/334 (2%)
Query: 4 EIYYSRKFLLHKPDNYHPENPGRLWLVLTAIRELGLENHVLEPSPIGEELIYRIHEREYV 63
+I Y+ + L HKP +YH ENP R+ +L +++ G ++ VL I IH R+YV
Sbjct: 7 KILYNPEVLGHKPKSYHVENPERVLTILNSLKSNGFDDIVLIEGKSTINEILEIHSRDYV 66
Query: 64 EKIRELSRRGGGYLDADTYVSPRTWEAAILALGASRLATLSALRYGGMNLALVRPPGHHA 123
I LS+ Y D DTY+ RT +AA+ A ++ A AL+ + AL RPPGHHA
Sbjct: 67 YSIINLSK-SFNYYDGDTYLCDRTLDAALTAFKLAKEAVKLALKDRDLYFALTRPPGHHA 125
Query: 124 GRRGKALGAPTLGFCIFNNSAMAALTSKEETGKALVIDFDAHHGNGTQEIFWDDADVVHI 183
G G+ALGA + GFCIFNN A AA +K K ++IDFD HHGNGTQEIFW+D V+HI
Sbjct: 126 GISGRALGAMSNGFCIFNNIAGAARLAKNYMKKVIIIDFDVHHGNGTQEIFWNDNRVIHI 185
Query: 184 DLHERDIYPGSGDVGEIGGINAKGSKINLPMPHYSEDGDYIYAWEEVVIPIVEEVKPKVV 243
D H+R IYPG+GD+ +IGG AKG+KINLP P +S D DYI+AW E+V PI+ P V
Sbjct: 186 DFHQRGIYPGTGDILDIGGEEAKGTKINLPFPAHSTDADYIFAWNEIVEPILNYFSPDTV 245
Query: 244 IVSAGFDGFKGDGLTTLKLTEVFYSYAGATLRKYPLAVILEGGYSSGLKKGFPAFIRGYE 303
+VSAGFD F DGL ++ LTE FY + GA L Y + +LEGGYS GLK PAF+ GY
Sbjct: 246 LVSAGFDAFINDGLASMDLTETFYRFVGAKLSGYSVTAVLEGGYSIGLKYAPPAFLDGYV 305
Query: 304 EDK-VRDHAQP-----SYETLKLVEEVKDILSPW 331
+ K V D+ + S E +V+ VK I+ +
Sbjct: 306 DAKDVLDNLEDYTVINSNEVKSMVKNVKKIIGEY 339
>gb|AAK40374.1| Deacetylase, putative [Sulfolobus solfataricus]
Length = 327
Score = 229 bits (577), Expect = 5e-59
Identities = 139/342 (40%), Positives = 198/342 (57%), Gaps = 30/342 (8%)
Query: 5 IYYSRKFLLHKPDNYHPENPGRLWLVLTAIRELGLENHVLEPSPIGEELIYRIHEREYVE 64
I Y + H P YH ENP R+ L+AI +L ++ +P + + I IH +YV+
Sbjct: 4 IVYDDIYKYHAPKGYHVENPSRIDKALSAINQLKVK--FKKPIKVDDPQI--IHSEDYVK 59
Query: 65 KIRELSRRGGGYLDADTYVSPRTWEAAILALGASRLATLSALRYGGMNLALVRPPGHHAG 124
+ + S+ LD DTY + T+E+A+ A+G + L A G ALVRPPGHHAG
Sbjct: 60 LVEKHSKLEEN-LDEDTYTNRYTYESALYAMGGA----LEAFETNGF--ALVRPPGHHAG 112
Query: 125 RRGKALGAPTLGFCIFNNSAMAALTSKEETGKALVIDFDAHHGNGTQEIFWDDADVVHID 184
G+A GAPTLGFCIFNN +A K + + +IDFD H+GNGTQEIF+DD D++HID
Sbjct: 113 VNGRAFGAPTLGFCIFNN--VAYPIKKYKLKRVAIIDFDVHYGNGTQEIFYDDPDILHID 170
Query: 185 LHE--RDIYPGSGDVGEIGGINAKGSKINLPMPHYSEDGDYIYAWEEVVIPIVEEV---- 238
+H+ R IYPG+G IG +A+G+KINL +P D Y E +IPI++ +
Sbjct: 171 VHQDPRTIYPGNGFPDMIGEKDAEGTKINLLIPPLGSDDLY-----EELIPIIQAILDDF 225
Query: 239 KPKVVIVSAGFDGFKGDGLTTLKLTE-VFYSYAGATLRKYPLAVILEGGYSSGLKKGFPA 297
KP V+ SAGFD + GDGL ++ TE FYS+ + + +LEGGY GL KG A
Sbjct: 226 KPAVIAYSAGFDSYMGDGLASVNATEYTFYSFGVLSNKFTKKYAVLEGGYDKGLIKGLKA 285
Query: 298 FIRGYEEDKVRDHAQPSYETLK-----LVEEVKDILSPWWSL 334
F+ G+ K+ S ++++ + E K+IL +WS+
Sbjct: 286 FLEGFANIKMEYKKYQSNDSVRSRFMNYLSEEKNILRNYWSI 327
>pir||G72762 probable acetylpolyamine aminohydrolase APE0092 - Aeropyrum pernix
(strain K1) >gi|5103480|dbj|BAA79001.1| (AP000058) 320aa
long hypothetical acetylpolyamine aminohydrolase
[Aeropyrum pernix]
Length = 320
Score = 211 bits (532), Expect = 9e-54
Identities = 114/261 (43%), Positives = 162/261 (61%), Gaps = 10/261 (3%)
Query: 48 PIGEELIY-RIHEREYVEKIRELSRRGGGYLDADTYVSPRTWEAAILALGASRLATLSAL 106
P+G+ +Y R+H Y+ + + G +LD DTYV P T A+ LG + + + +
Sbjct: 4 PVGDVGLYTRVHSPAYLRHVLSTAESGLDWLDPDTYVGPGTL-VALKRLGGASVEVYNIV 62
Query: 107 RYGGMNLALVRPPGHHAGRRGKALGAPTLGFCIFNNSAMAALTSKEETGKALVIDFDAHH 166
R GG L L RPPGHHAG RG+ALGAPT GFCI N +A+ A E+ GK +++DFD HH
Sbjct: 63 RSGGEALLLGRPPGHHAGIRGRALGAPTAGFCIVNTAALIARMLSEQ-GKTVILDFDLHH 121
Query: 167 GNGTQEIFWDDADVVHIDLHE--RDIYPGSGDVGEIGGINAKGSKINLPMPHYSEDGDYI 224
GNGTQEIF+DD DV H+D+H+ IYPG+G +IG +AKG+KIN+ +P S D Y+
Sbjct: 122 GNGTQEIFYDDPDVYHVDVHQDPTTIYPGTGFPEDIGEGDAKGTKINIILPPNSGDDIYV 181
Query: 225 YAWEEVVIPIVEEVKPKVVIVSAGFDGFKGD-GLTTLKLTEVFYSYAGATLRKYP---LA 280
A + + I+E ++P ++VSAGFD ++GD T ++ Y G+ L + +A
Sbjct: 182 SA-ARLALGILERLEPDYIVVSAGFDAYRGDNAFTVMRGGTAMYYLIGSELSRMARRGVA 240
Query: 281 VILEGGYSSGLKKGFPAFIRG 301
+LEGGY GL++ PAF G
Sbjct: 241 AVLEGGYGVGLRRALPAFAAG 261
>sp|O27262|YB94_METTH HYPOTHETICAL PROTEIN MTH1194 >gi|7430156|pir||C69026
acetylpolyamine aminohydrolase - Methanobacterium
thermoautotrophicum (strain Delta H)
>gi|2622302|gb|AAB85683.1| (AE000887) acetylpolyamine
aminohydolase [Methanobacterium thermoautotrophicum]
Length = 331
Score = 199 bits (500), Expect = 5e-50
Identities = 115/336 (34%), Positives = 184/336 (54%), Gaps = 15/336 (4%)
Query: 5 IYYSRKFLLHKPDNYHPENPGRLWLVLTAIRELGLENHVLEPSPIGEELIYRIHEREYVE 64
I +S + LH + H EN GR +L AI L +EP G + I +H +VE
Sbjct: 3 IIHSPSYDLHNHEG-HVENSGRTRAILRAIESSDLSPRFVEPGMAGIDDILMVHSSTHVE 61
Query: 65 KIRELSRRGGGYLDADTYVSPRTWEAAILALGASRLATLSALRYGGMNLALVRPPGHHAG 124
+ + RGGG+LD DTY++P ++ A L+ G + LA ALR G + +L RPPGHH
Sbjct: 62 YLEVFAGRGGGWLDYDTYMTPESFSVARLSAGGAMLAAEEALR-DGWSYSLGRPPGHH-- 118
Query: 125 RRGKALGAPTLGFCIFNNSAMAALTSKEETG--KALVIDFDAHHGNGTQEIFWDDADVVH 182
A ++GFCIFNN A+A ++ G + LV+DFD HHGNGT IF+ D DV++
Sbjct: 119 ----ATYDRSMGFCIFNNIAIAIEHARRNLGVSRPLVLDFDVHHGNGTSSIFYRDRDVMY 174
Query: 183 IDLHE--RDIYPGSGDVGEIGGINAKGSKINLPMPHYSEDGDYIYAWEEVVIPIVEEVKP 240
I +H+ R ++PG+G + E G +G +N+PMP S + +Y++ ++ ++E +P
Sbjct: 175 ISIHQDPRTLFPGTGFIDETGSGEGEGFNLNIPMPRGSGNREYLWILGMILPAVLEGFRP 234
Query: 241 KVVIVSAGFDGFKGDGLTTLKLTEVFYSYAGATLRK--YPLAVILEGGYS-SGLKKGFPA 297
++ VSAGFD + D L + + E F+S+ G + + P +LEGGY L + A
Sbjct: 235 DMIFVSAGFDAHRRDPLAEIMVDEEFFSWIGWFIHQTGLPCTAVLEGGYDPEALGRSNIA 294
Query: 298 FIRGYEEDKVRDHAQPSYETLKLVEEVKDILSPWWS 333
F+RG + ++ ++ ++ D S +++
Sbjct: 295 FMRGLDGEEYEPETAAPGGVSEIFSQLSDRFSAYFN 330
>pir||F72602 probable acetylpolyamine aminohydrolase APE1285 - Aeropyrum pernix
(strain K1) >gi|5104962|dbj|BAA80276.1| (AP000061) 373aa
long hypothetical acetylpolyamine aminohydrolase
[Aeropyrum pernix]
Length = 373
Score = 182 bits (456), Expect = 7e-45
Identities = 125/340 (36%), Positives = 183/340 (53%), Gaps = 25/340 (7%)
Query: 4 EIYYSRKFLLHKPD--NYHPENPGRLWLVLTAIRELGLENHVLEPSPIGEEL--IYRIHE 59
++YYS F +H P + H E P RL L A+++ L + + + P + L +H+
Sbjct: 36 KLYYSMAFKMHVPPRGSGHIEEPRRLDKALKALKKSRLLDMLEKVDPGFQSLRVFETVHD 95
Query: 60 REYVEKI-RELSRRGGGY-LDADTYVSPRTWEAAILALGASRLATLSALRYGGMNLALVR 117
Y++ I EL Y +D+DTY+SP T +AA+ AL AS + GG L L R
Sbjct: 96 PLYIKGILAELEAALDSYFIDSDTYISPGT-QAALEALAASVEQASEHVAEGGKALVLGR 154
Query: 118 PPGHHAGRRGKALGAPTLGFCIFNNSAMAALTSKEETGKALVIDFDAHHGNGTQEIFWD- 176
PPGHHAG G LGAP+LG C+ N +A A K L++DFDA+HGNGTQEI
Sbjct: 155 PPGHHAGVAGPGLGAPSLGACLVNAAASLAYRLAGRGLKVLILDFDANHGNGTQEILQAL 214
Query: 177 --DADVVHIDLHE--RDIYPGSGDVGEIGGINAKGSKINLPMPHYSEDGDYIYAWEEVVI 232
+ H+D+H+ R +P +G+ G+ G+ +N+ +P S D D + A E +
Sbjct: 215 PMGDRLFHLDMHQDWRKSFPWTGE----PGVTGDGTALNIVLPEGSGD-DIVLALIEGLE 269
Query: 233 PIVEEVKPKVVIVSAGFDGFKGDG-LTTLKLTEVFYSYAGATLRKYPLAVILEGGYSSGL 291
P+V E +P V+VS GFDG+ GD LT KLT + G +YP+A +LE G+ GL
Sbjct: 270 PLVNESEPDAVVVSMGFDGYSGDSPLTLTKLTSHTFHALGRLASRYPVAAVLETGFGRGL 329
Query: 292 KKGFPAFIRG-------YEEDKVRDHAQPSYETLKLVEEV 324
+ G PAFI G +E+ ++ + E L+ +EV
Sbjct: 330 ELGLPAFIAGLLGLGNPVQEEAIKSDEEVWREFLETNKEV 369
>gb|AAG18756.1| (AE004980) acetoin utilization protein; Aup [Halobacterium sp.
NRC-1]
Length = 338
Score = 169 bits (423), Expect = 5e-41
Identities = 100/294 (34%), Positives = 151/294 (51%), Gaps = 20/294 (6%)
Query: 7 YSRKFLLHKPDNYHPENPGRLWLVLTAIRELGLENHVLEPSPIGE-ELIYRIHEREYVEK 65
+S L H P HPE+P RL + +++ E +P + I +H+ +Y +
Sbjct: 5 FSEACLEHDPGVRHPESPDRLRAIKRGLQKR--HGVTYEDAPDADLSDITAVHDPDYATE 62
Query: 66 IRELSRRGGGYLDADTYVSPRTWEAAILALGASRLATLSALRYGGMN---LALVRPPGHH 122
+R RGGG D DT + TW A + G + A +AL +L RPPGHH
Sbjct: 63 VRSFCERGGGSWDPDTAATESTWPAIRASAGLAMDAIDAALDGADGRDTPFSLGRPPGHH 122
Query: 123 AGRRGKALGAPTLGFCIFNNSAMAALTSKEETG--KALVIDFDAHHGNGTQEIFWDDADV 180
A + +GFC NN+A+AA + + G + + D+D HHGNGTQ+IF+D DV
Sbjct: 123 A------ITDDAMGFCFVNNAAVAAQHALDAHGLDRVAIFDWDVHHGNGTQDIFYDRGDV 176
Query: 181 VHIDLHERDIYPGSGDVGEIGGINAKGSKINLPMPHYSEDGDYIYAWEEVVIPIVEEVKP 240
+ +HE +YPG+G V + G + G+ +NLP P + D DY A ++ + P + P
Sbjct: 177 FYTSIHEDGLYPGTGSVAQTGDCDGAGTTLNLPFPTGAGDADYAAAVDDFIAPAIRAFDP 236
Query: 241 KVVIVSAGFDGFKGDGLTTLKLTEVFYSYAGATLRKY------PLAVILEGGYS 288
+ +VSAGFD D ++ L L+ Y+ +R+ PLA +LEGGYS
Sbjct: 237 DLFVVSAGFDAHHHDPISRLHLSTEGYAMLTDRVRRISARTDAPLAFVLEGGYS 290
>pir||A70481 acetoin utilization protein - Aquifex aeolicus
>gi|2984320|gb|AAC07842.1| (AE000773) acetoin
utilization protein [Aquifex aeolicus]
Length = 310
Score = 166 bits (416), Expect = 3e-40
Identities = 99/281 (35%), Positives = 149/281 (52%), Gaps = 19/281 (6%)
Query: 20 HPENPGRLWLVLTAIRELGLENHVLEPSP--IGEELIYRIHEREYVEKIRELSRRGGGYL 77
HPEN RL +L + + G++ +++ P E + H+ Y+++I + + GGGYL
Sbjct: 20 HPENKNRLISILEHVEKSGIKKALIDVKPRRAKVEEVALNHDPAYIQEIHDFCKSGGGYL 79
Query: 78 DADTYVSPRTWEAAILALGASRLATLSALRYGGMNLAL--VRPPGHHAGRRGKALGAPTL 135
D DTY +P T++ A+ A+G L + + G ++ A VRPPGHHA A +
Sbjct: 80 DPDTYATPDTYDVALYAVGGV-LEGIDRILSGELDRAFCAVRPPGHHAEY------AKAM 132
Query: 136 GFCIFNNSAMAA--LTSKEETGKALVIDFDAHHGNGTQEIFWDDADVVHIDLHERDIYPG 193
GFCIFNN A+ A L + K +IDFDAHHGNGTQ+ F++D V + HE YPG
Sbjct: 133 GFCIFNNVAIGAHYLRKIKGVNKVFIIDFDAHHGNGTQKSFYEDDTVFYFSTHEYPFYPG 192
Query: 194 SGDVGEIGGINAKGSKINLPMPHYSEDGDYIYAWEEVVIPIVEEVKPKVVIVSAGFDGFK 253
+G E G G N+PM + D +YI +E+++ ++ P V+VSAG+D +
Sbjct: 193 TGSEDERGAGKGYGYTYNVPMSAGAGDDEYIPVYEKLLPELMNRFSPDFVLVSAGYDLHR 252
Query: 254 GDGLTTLKLTEVFYSYAGATLRK------YPLAVILEGGYS 288
D LT L ++ + K P+ LEGGY+
Sbjct: 253 DDPLTYLNVSNEGVRQIVRNIIKTSDELNAPVLFALEGGYN 293
>gi|11497747 acetylpolyamine aminohydrolase (aphA) [Archaeoglobus fulgidus]
>gi|3024859|sp|O30107|Y130_ARCFU HYPOTHETICAL PROTEIN
AF0130 >gi|7430157|pir||B69266 acetylpolyamine
aminohydrolase (aphA) homolog - Archaeoglobus fulgidus
>gi|2650515|gb|AAB91099.1| (AE001097) acetylpolyamine
aminohydrolase (aphA) [Archaeoglobus fulgidus]
Length = 359
Score = 166 bits (415), Expect = 5e-40
Identities = 118/362 (32%), Positives = 181/362 (49%), Gaps = 37/362 (10%)
Query: 1 MIGEIYYSRKFLLHKPDNYHPENPGRLWLVLTAIRELGLENH----VLEPSPIGEELIYR 56
M+ I + ++L H+ HPE RL + +RE G+ +LEP E +
Sbjct: 1 MVTGIVFHEEYLKHEQSPTHPERRERLAYTMDQLREEGIFESERIVLLEPFKASLEDVLE 60
Query: 57 IHEREYVEKIRELSRRGGGYLDADTYVSPRTWEAAILALGASRLATLSALRYGGMN-LAL 115
+H EYV + E+ + GG +D DT + ++ A+LA G + A + L N A+
Sbjct: 61 VHTEEYV-RFLEMESKKGGIIDFDTNIPVGVFDRALLAAGGAIRAAQAVLNKECENAFAM 119
Query: 116 VRPPGHHAGRRGKALGAPTLGFCIFNNSA-MAALTSKEETGKALVIDFDAHHGNGTQEIF 174
+RPPGHHA +GA GFC NN A M K+ + ++D+DAHHG+GTQEIF
Sbjct: 120 IRPPGHHAK---PYIGA---GFCYLNNMAIMVKWLLKQGFERIAILDWDAHHGDGTQEIF 173
Query: 175 WDDADVVHIDLHERDIYPGSGDVGEIGGINAKGSKINLPMPHYSEDGDYIYAWEEVVIPI 234
++D V+ I H+ +YPG+G E G +G +N+P+P + D Y+ +E++ P+
Sbjct: 174 YNDDRVLFISTHQMPLYPGTGYPEECGTGKGEGYTVNIPLPPGTGDEGYMMVIDEIIEPV 233
Query: 235 VEEVKPKVVIVSAGFDGFKGDGLTTLKLTEVFYS----YAGATLRKY---PLAVILEGGY 287
V E KP+ + +SAG D D +T+L LT Y+ A A K+ L +LEGGY
Sbjct: 234 VNEFKPQFIAISAGQDNHFTDPITSLALTARGYAEMMRRAVAMAEKHCDGRLVAVLEGGY 293
Query: 288 S-----SGLKKGFPAFIRGYEEDKVRDHAQPSYETL---------KL---VEEVKDILSP 330
S G A + G++ +R+ E L KL +E+VK + S
Sbjct: 294 SVEGALPYTNLGIIAAMAGFDLSAIREPENYLPELLWRKRDSALVKLKHNIEDVKRVHSK 353
Query: 331 WW 332
+W
Sbjct: 354 YW 355
>sp|P72702|Y245_SYNY3 HYPOTHETICAL 33.6 KD PROTEIN SLR0245 >gi|7430155|pir||S74557
acetylpolyamine aminohydrolase - Synechocystis sp.
(strain PCC 6803) >gi|1651782|dbj|BAA16709.1| (D90900)
acetylpolyamine aminohydolase [Synechocystis sp.]
Length = 304
Score = 163 bits (408), Expect = 3e-39
Identities = 105/293 (35%), Positives = 156/293 (52%), Gaps = 20/293 (6%)
Query: 5 IYYSRKFLLHKPDNYHPENPGRLWLVLTAIRELGLEN--HVLEPSPIGEEL---IYRIHE 59
I YS +FL H+ HPE P RL + TA+R++ N H +PSP+ L I R H
Sbjct: 4 IIYSAEFLRHETGPTHPECPARLTAIATALRKMPGANYLHWQKPSPVTWNLDPYILRCHS 63
Query: 60 REYVEKIRELSRRGGGYLDADTYVSPRTWEAAILALGASRLATLSALRYGGMNLALVRPP 119
+EY+ K+ +L+ GGG LDADT VSP++++ A LA+ A L L RPP
Sbjct: 64 QEYLNKLAKLAELGGGSLDADTPVSPQSYDVARLAVRAWLDGVDHVLNQREAVFVLARPP 123
Query: 120 GHHAGRRGKALGAPTLGFCIFNNSAMAALTSKEETG--KALVIDFDAHHGNGTQEIFWDD 177
GHHA R +GFC+ NN A+AA + G + ++D+D HHGNGT+ + +
Sbjct: 124 GHHAIRN------TGMGFCLLNNVAIAAHYALTRPGVERVAILDWDVHHGNGTEALVDHN 177
Query: 178 ADVVHIDLHERDIYPGSGDVGEIGGINAKGSKINLPMPHYSEDGDYIYAWEEVVIPIVEE 237
+ + LH+ YPG+G G+ G + +N+P+ + Y A+E V+P + +
Sbjct: 178 PRIFYCSLHQFPCYPGTGAAGDRG---QHDNVLNIPLKPGGDGKVYREAFEHKVLPFLRQ 234
Query: 238 VKPKVVIVSAGFDGFKGDGLTTLKLTEVFYSYAGATLRK---YPLAVILEGGY 287
VKP +++VSAG+D D L + L Y L + YP+ + LEGGY
Sbjct: 235 VKPDLLLVSAGYDANHSDPLAYMNLIPEDYGMMTHYLMEISPYPV-LGLEGGY 286
>pir||T13964 probable histone deacetylase (EC 3.5.1.-) HDA2 - mouse
Length = 1095
Score = 157 bits (394), Expect = 1e-37
Identities = 113/314 (35%), Positives = 162/314 (50%), Gaps = 43/314 (13%)
Query: 5 IYYSRKFLLHKP--DNYHPENPGRLWLVLTAIRELGLENH--VLEPSP-IGEELIYRIHE 59
+ Y K + H DN+HPE P R+ ++ + E+GL +L P +G EL+ H
Sbjct: 428 LVYDEKMMSHCNLWDNHHPETPQRILRIMCHLEEVGLAARCLILPARPALGSELL-TCHS 486
Query: 60 REYVE--------KIRELSRRGGGYLDADTYVSPRTWEAAILALGASRLATLSALRYGGM 111
EYVE K R+L R G + Y+ P T+ A LA GA+ + L +
Sbjct: 487 AEYVEHLRTTEKMKTRDLHREGANF--DSIYICPSTFACAKLATGAACRLVEAVLSGEVL 544
Query: 112 N-LALVRPPGHHAGRRGKALGAPTLGFCIFNNSAMAALTSKEETGKAL---VIDFDAHHG 167
N +A+VRPPGHHA GFC FN+ A+AA ++ G+AL ++D+D HHG
Sbjct: 545 NGIAVVRPPGHHAEPNAAC------GFCFFNSVAVAARHAQIIAGRALRILIVDWDVHHG 598
Query: 168 NGTQEIFWDDADVVHIDLHERD---IYP-----GSGDVGEIGGINAKGSKINLPM--PHY 217
NGTQ IF DD V+++ LH D +P S VG GI G +N+P P
Sbjct: 599 NGTQHIFEDDPSVLYVSLHRYDRGTFFPMGDEGASSQVGRDAGI---GFTVNVPWNGPRM 655
Query: 218 SEDGDYIYAWEEVVIPIVEEVKPKVVIVSAGFDGFKGDGLTTLKLTEVFYSYAGATLRKY 277
D DY+ AW +V+PI E P++V++SAGFD +GD L ++T Y++ L
Sbjct: 656 G-DADYLAAWHRLVLPIAYEFNPELVLISAGFDAAQGDPLGGCQVTPEGYAHLTHLLMGL 714
Query: 278 P---LAVILEGGYS 288
+ +ILEGGY+
Sbjct: 715 AGGRIILILEGGYN 728
Score = 111 bits (275), Expect = 1e-23
Identities = 92/303 (30%), Positives = 144/303 (47%), Gaps = 29/303 (9%)
Query: 17 DNYHPENPGRLWLVLTAIRELGLENHVLEPSP--IGEELIYRIHEREYVEKIRELSRRGG 74
D+ PE+P RL + + GL + +E + +H EY++ +
Sbjct: 47 DDSFPESPERLHAIREQLILEGLLGRCVSFQAWFAEKEELMLVHSLEYIDLMETTQYMNE 106
Query: 75 GYLD--ADTYVS----PRTWEAAILALGASRLATLSALRYGGMN--LALVRPPGHHAGRR 126
G L A+TY S P ++ A LA G S L + AL + +A++RPPGHHA
Sbjct: 107 GELRVLAETYDSVYLHPNSYSCACLATG-SVLRLVDALMGAEIRNGMAVIRPPGHHAQHN 165
Query: 127 GKALGAPTLGFCIFNNSAMAA--LTSKEETGKALVIDFDAHHGNGTQEIFWDDADVVHID 184
G+C+FN+ A+AA K + L++D+D HHG GTQ IF D V++
Sbjct: 166 LMD------GYCMFNHLAVAARYAQKKHRIQRVLIVDWDVHHGQGTQFIFDQDPSVLYFS 219
Query: 185 LHERD---IYPG--SGDVGEIGGINAKGSKINLPMPHYS-EDGDYIYAWEEVVIPIVEEV 238
+H + +P + + IG +G IN+P D DYI A+ +++P+ E
Sbjct: 220 IHRYEHGRFWPHLKASNWSTIGFGQGQGYTINVPWNQTGMRDADYIAAFLHILLPVASEF 279
Query: 239 KPKVVIVSAGFDGFKGDGLTTLKLTEVFYSYAGATLRKY---PLAVILEGGYS-SGLKKG 294
+P++V+V+AGFD GD + T +++ L L + LEGGY+ L KG
Sbjct: 280 QPQLVLVAAGFDALHGDPKGEMAATPAGFAHLTHLLMGLAGGKLILSLEGGYNLRALAKG 339
Query: 295 FPA 297
A
Sbjct: 340 ISA 342
>gi|6996926 histone deacetylase 6; histone deacetylase 5 [Mus musculus]
>gi|10720028|sp|Q9Z2V5|HDA6_MOUSE HISTONE DEACETYLASE 6
(HD6) (HISTONE DEACETYLASE MHDA2)
>gi|6978316|gb|AAD09835.2| (AF006603) histone
deacetylase mHDA2 [Mus musculus]
Length = 1149
Score = 157 bits (394), Expect = 1e-37
Identities = 113/314 (35%), Positives = 162/314 (50%), Gaps = 43/314 (13%)
Query: 5 IYYSRKFLLHKP--DNYHPENPGRLWLVLTAIRELGLENH--VLEPSP-IGEELIYRIHE 59
+ Y K + H DN+HPE P R+ ++ + E+GL +L P +G EL+ H
Sbjct: 482 LVYDEKMMSHCNLWDNHHPETPQRILRIMCHLEEVGLAARCLILPARPALGSELL-TCHS 540
Query: 60 REYVE--------KIRELSRRGGGYLDADTYVSPRTWEAAILALGASRLATLSALRYGGM 111
EYVE K R+L R G + Y+ P T+ A LA GA+ + L +
Sbjct: 541 AEYVEHLRTTEKMKTRDLHREGANF--DSIYICPSTFACAKLATGAACRLVEAVLSGEVL 598
Query: 112 N-LALVRPPGHHAGRRGKALGAPTLGFCIFNNSAMAALTSKEETGKAL---VIDFDAHHG 167
N +A+VRPPGHHA GFC FN+ A+AA ++ G+AL ++D+D HHG
Sbjct: 599 NGIAVVRPPGHHAEPNAAC------GFCFFNSVAVAARHAQIIAGRALRILIVDWDVHHG 652
Query: 168 NGTQEIFWDDADVVHIDLHERD---IYP-----GSGDVGEIGGINAKGSKINLPM--PHY 217
NGTQ IF DD V+++ LH D +P S VG GI G +N+P P
Sbjct: 653 NGTQHIFEDDPSVLYVSLHRYDRGTFFPMGDEGASSQVGRDAGI---GFTVNVPWNGPRM 709
Query: 218 SEDGDYIYAWEEVVIPIVEEVKPKVVIVSAGFDGFKGDGLTTLKLTEVFYSYAGATLRKY 277
D DY+ AW +V+PI E P++V++SAGFD +GD L ++T Y++ L
Sbjct: 710 G-DADYLAAWHRLVLPIAYEFNPELVLISAGFDAAQGDPLGGCQVTPEGYAHLTHLLMGL 768
Query: 278 P---LAVILEGGYS 288
+ +ILEGGY+
Sbjct: 769 AGGRIILILEGGYN 782
Score = 111 bits (275), Expect = 1e-23
Identities = 92/303 (30%), Positives = 144/303 (47%), Gaps = 29/303 (9%)
Query: 17 DNYHPENPGRLWLVLTAIRELGLENHVLEPSP--IGEELIYRIHEREYVEKIRELSRRGG 74
D+ PE+P RL + + GL + +E + +H EY++ +
Sbjct: 101 DDSFPESPERLHAIREQLILEGLLGRCVSFQAWFAEKEELMLVHSLEYIDLMETTQYMNE 160
Query: 75 GYLD--ADTYVS----PRTWEAAILALGASRLATLSALRYGGMN--LALVRPPGHHAGRR 126
G L A+TY S P ++ A LA G S L + AL + +A++RPPGHHA
Sbjct: 161 GELRVLAETYDSVYLHPNSYSCACLATG-SVLRLVDALMGAEIRNGMAVIRPPGHHAQHN 219
Query: 127 GKALGAPTLGFCIFNNSAMAA--LTSKEETGKALVIDFDAHHGNGTQEIFWDDADVVHID 184
G+C+FN+ A+AA K + L++D+D HHG GTQ IF D V++
Sbjct: 220 LMD------GYCMFNHLAVAARYAQKKHRIQRVLIVDWDVHHGQGTQFIFDQDPSVLYFS 273
Query: 185 LHERD---IYPG--SGDVGEIGGINAKGSKINLPMPHYS-EDGDYIYAWEEVVIPIVEEV 238
+H + +P + + IG +G IN+P D DYI A+ +++P+ E
Sbjct: 274 IHRYEHGRFWPHLKASNWSTIGFGQGQGYTINVPWNQTGMRDADYIAAFLHILLPVASEF 333
Query: 239 KPKVVIVSAGFDGFKGDGLTTLKLTEVFYSYAGATLRKY---PLAVILEGGYS-SGLKKG 294
+P++V+V+AGFD GD + T +++ L L + LEGGY+ L KG
Sbjct: 334 QPQLVLVAAGFDALHGDPKGEMAATPAGFAHLTHLLMGLAGGKLILSLEGGYNLRALAKG 393
Query: 295 FPA 297
A
Sbjct: 394 ISA 396
>gb|AAK40394.1| Acetylpolyamine aminohydrolase [Sulfolobus solfataricus]
Length = 351
Score = 152 bits (379), Expect = 8e-36
Identities = 89/263 (33%), Positives = 143/263 (53%), Gaps = 16/263 (6%)
Query: 6 YYSRKFLLHKPDNYHPENPGRLWLVLTAIRELGLENHV--LEPSPIGEELIYRIHEREYV 63
YY+ F PD YHP R + + E G + + +EP I EE + +H +EY+
Sbjct: 12 YYNYSF----PD-YHPFKSLRESMTKRLLEERGAFHFITLVEPKSIPEEALQLVHSKEYI 66
Query: 64 EKIRELSRRGGGYLD-ADTYVSPRTWEAAILALGASRLATLSALRYGGMNLALVRPPGHH 122
E ++ S+ G GYLD DT +EAA++ + S + L ++ G N + G H
Sbjct: 67 EFVKYKSKEGQGYLDDGDTPAFKGIYEAALIRVSGS-VKALELIKSGEFNHTINIGGGFH 125
Query: 123 AGRRGKALGAPTLGFCIFNNSAMAALTSKEETGKALVIDFDAHHGNGTQEIFWDDADVVH 182
+R +A G FC+FN+ A+ + + + ++D D HH +GTQE+ DD +++
Sbjct: 126 HAKRNRAAG-----FCVFNDVALISKLGESFFSRIAIVDIDGHHADGTQELLIDDNNILK 180
Query: 183 IDLH--ERDIYPGSGDVGEIGGINAKGSKINLPMPHYSEDGDYIYAWEEVVIPIVEEVKP 240
I LH + +PG+GDV EIG +G IN+P+P + D Y+ A++E+V+P +E KP
Sbjct: 181 ISLHMFHPNFFPGTGDVNEIGLGKGEGYTINIPLPPGTGDDGYLLAFDEIVVPAIERYKP 240
Query: 241 KVVIVSAGFDGFKGDGLTTLKLT 263
+++I+ AG D D L LKL+
Sbjct: 241 ELIILVAGGDSHFNDPLVELKLS 263
>gb|AAF36540.1| (AF174499) GR AF-1 specific histone deacetylase [Homo sapiens]
Length = 1066
Score = 151 bits (377), Expect = 1e-35
Identities = 106/297 (35%), Positives = 152/297 (50%), Gaps = 35/297 (11%)
Query: 17 DNYHPENPGRLWLVLTAIRELGLENH--VLEPSPIGEELIYRIHEREYVE--------KI 66
D++HPE P R+ ++ + ELGL L P P E + H EYV K
Sbjct: 348 DSHHPEVPQRILRIMCRLEELGLAGRCLTLTPRPATEAELLTCHSAEYVGHLRATEKMKT 407
Query: 67 RELSRRGGGYLDADTYVSPRTWEAAILALGASRLATLSALRYGGMN-LALVRPPGHHAGR 125
REL R + Y+ P T+ A LA GA+ + L +N A+VRPPGHHA +
Sbjct: 408 RELHRESSNF--DSIYICPSTFACAQLATGAACRLVEAVLSGEVLNGAAVVRPPGHHAEQ 465
Query: 126 RGKALGAPTLGFCIFNNSAMAALTSKEETGKAL---VIDFDAHHGNGTQEIFWDDADVVH 182
GFC FN+ A+AA ++ +G AL ++D+D HHGNGTQ +F DD V++
Sbjct: 466 DAAC------GFCFFNSVAVAARHAQTISGHALRILIVDWDVHHGNGTQHMFEDDPSVLY 519
Query: 183 IDLHERD---IYPGSGDVG---EIGGINAKGSKINLPM--PHYSEDGDYIYAWEEVVIPI 234
+ LH D +P GD G +IG G +N+ P D DY+ AW +V+PI
Sbjct: 520 VSLHRYDHGTFFP-MGDEGASSQIGRAAGTGFTVNVAWNGPRMG-DADYLAAWHRLVLPI 577
Query: 235 VEEVKPKVVIVSAGFDGFKGDGLTTLKLTEVFYSYAGATLRKYP---LAVILEGGYS 288
E P++V+VSAGFD +GD L +++ Y++ L + +ILEGGY+
Sbjct: 578 AYEFNPELVLVSAGFDAARGDPLGGCQVSPEGYAHLTHLLMGLASGRIILILEGGYN 634
Score = 101 bits (249), Expect = 1e-20
Identities = 88/283 (31%), Positives = 132/283 (46%), Gaps = 40/283 (14%)
Query: 79 ADTYVS----PRTWEAAILALGAS-RL--ATLSALRYGGMNLALVRPPGHHAGRRGKALG 131
ADTY S P ++ A LA G+ RL A L A GM A++RPPGHHA
Sbjct: 19 ADTYDSVYLHPNSYSCACLASGSVLRLVDAVLGAEIRNGM--AIIRPPGHHAQH------ 70
Query: 132 APTLGFCIFNNSAMAA--LTSKEETGKALVIDFDAHHGNGTQEIFWDDADVVHIDLHERD 189
+ G+C+FN+ A+AA K + L++D+D HHG GTQ F D V++ +H +
Sbjct: 71 SLMDGYCMFNHVAVAARYAQQKHRIRRVLILDWDVHHGQGTQFTFDQDPSVLYFSIHRYE 130
Query: 190 ---IYPG--SGDVGEIGGINAKGSKINLPMPHYS-EDGDYIYAWEEVVIPIVEEVKPKVV 243
+P + + G +G IN+P D DYI A+ V++P+ E +P++V
Sbjct: 131 QGRFWPHLKASNWSTTGFGQGQGYTINVPWNQVGMRDADYIAAFLHVLLPVALEFQPQLV 190
Query: 244 IVSAGFDGFKGDGLTTL--------KLTEVFYSYAGATLRKYPLAVILEGGYS-SGLKKG 294
+V+AGFD +GD + +LT + AG L + LEGGY+ L +G
Sbjct: 191 LVAAGFDALQGDPKGEMAATPAGFAQLTHLLMGLAGG-----KLILSLEGGYNLRALAEG 245
Query: 295 FPAFIR---GYEEDKVRDHAQPSYETLKLVEEVKDILSPWWSL 334
A + G + P V + L P+W +
Sbjct: 246 VSASLHTLLGDPGPMLESPGAPCRSAQASVSCALEALEPFWEV 288
>gi|11420048 histone deacetylase 6 [Homo sapiens] >gi|4240291|dbj|BAA74924.1|
(AB020708) KIAA0901 protein [Homo sapiens]
>gi|6289082|gb|AAF06807.1|AF196971_2 (AF196971) histone
deacetylase-like protein [Homo sapiens]
Length = 1215
Score = 151 bits (377), Expect = 1e-35
Identities = 106/297 (35%), Positives = 152/297 (50%), Gaps = 35/297 (11%)
Query: 17 DNYHPENPGRLWLVLTAIRELGLENH--VLEPSPIGEELIYRIHEREYVE--------KI 66
D++HPE P R+ ++ + ELGL L P P E + H EYV K
Sbjct: 497 DSHHPEVPQRILRIMCRLEELGLAGRCLTLTPRPATEAELLTCHSAEYVGHLRATEKMKT 556
Query: 67 RELSRRGGGYLDADTYVSPRTWEAAILALGASRLATLSALRYGGMN-LALVRPPGHHAGR 125
REL R + Y+ P T+ A LA GA+ + L +N A+VRPPGHHA +
Sbjct: 557 RELHRESSNF--DSIYICPSTFACAQLATGAACRLVEAVLSGEVLNGAAVVRPPGHHAEQ 614
Query: 126 RGKALGAPTLGFCIFNNSAMAALTSKEETGKAL---VIDFDAHHGNGTQEIFWDDADVVH 182
GFC FN+ A+AA ++ +G AL ++D+D HHGNGTQ +F DD V++
Sbjct: 615 DAAC------GFCFFNSVAVAARHAQTISGHALRILIVDWDVHHGNGTQHMFEDDPSVLY 668
Query: 183 IDLHERD---IYPGSGDVG---EIGGINAKGSKINLPM--PHYSEDGDYIYAWEEVVIPI 234
+ LH D +P GD G +IG G +N+ P D DY+ AW +V+PI
Sbjct: 669 VSLHRYDHGTFFP-MGDEGASSQIGRAAGTGFTVNVAWNGPRMG-DADYLAAWHRLVLPI 726
Query: 235 VEEVKPKVVIVSAGFDGFKGDGLTTLKLTEVFYSYAGATLRKYP---LAVILEGGYS 288
E P++V+VSAGFD +GD L +++ Y++ L + +ILEGGY+
Sbjct: 727 AYEFNPELVLVSAGFDAARGDPLGGCQVSPEGYAHLTHLLMGLASGRIILILEGGYN 783
Score = 111 bits (274), Expect = 2e-23
Identities = 102/349 (29%), Positives = 159/349 (45%), Gaps = 44/349 (12%)
Query: 17 DNYHPENPGRLWLVLTAIRELGLENHVL--EPSPIGEELIYRIHEREYVEKIRELSRRGG 74
D+ PE P RL + + + GL + + + +E + +H EY++ +
Sbjct: 102 DDSFPEGPERLHAIKEQLIQEGLLDRCVSFQARFAEKEELMLVHSLEYIDLMETTQYMNE 161
Query: 75 GYLD--ADTYVS----PRTWEAAILALGAS-RL--ATLSALRYGGMNLALVRPPGHHAGR 125
G L ADTY S P ++ A LA G+ RL A L A GM A++RPPGHHA
Sbjct: 162 GELRVLADTYDSVYLHPNSYSCACLASGSVLRLVDAVLGAEIRNGM--AIIRPPGHHAQH 219
Query: 126 RGKALGAPTLGFCIFNNSAMAA--LTSKEETGKALVIDFDAHHGNGTQEIFWDDADVVHI 183
+ G+C+FN+ A+AA K + L++D+D HHG GTQ F D V++
Sbjct: 220 ------SLMDGYCMFNHVAVAARYAQQKHRIRRVLIVDWDVHHGQGTQFTFDQDPSVLYF 273
Query: 184 DLHERD---IYPG--SGDVGEIGGINAKGSKINLPMPHYS-EDGDYIYAWEEVVIPIVEE 237
+H + +P + + G +G IN+P D DYI A+ V++P+ E
Sbjct: 274 SIHRYEQGRFWPHLKASNWSTTGFGQGQGYTINVPWNQVGMRDADYIAAFLHVLLPVALE 333
Query: 238 VKPKVVIVSAGFDGFKGDGLTTL--------KLTEVFYSYAGATLRKYPLAVILEGGYS- 288
+P++V+V+AGFD +GD + +LT + AG L + LEGGY+
Sbjct: 334 FQPQLVLVAAGFDALQGDPKGEMAATPAGFAQLTHLLMGLAGG-----KLILSLEGGYNL 388
Query: 289 SGLKKGFPAFIRGYEED---KVRDHAQPSYETLKLVEEVKDILSPWWSL 334
L +G A + D + P V + L P+W +
Sbjct: 389 RALAEGVSASLHTLLGDPCPMLESPGAPCRSAQASVSCALEALEPFWEV 437
>gi|5174489 histone deacetylase 6 [Homo sapiens]
>gi|10720024|sp|Q9UBN7|HDA6_HUMAN HISTONE DEACETYLASE 6
(HD6) >gi|3776071|emb|CAA09893.1| (AJ011972) histone
deacetylase-like protein [Homo sapiens]
>gi|4754911|gb|AAD29048.1|AF132609_1 (AF132609) histone
deacetylase 6 [Homo sapiens]
Length = 1215
Score = 151 bits (377), Expect = 1e-35
Identities = 106/297 (35%), Positives = 152/297 (50%), Gaps = 35/297 (11%)
Query: 17 DNYHPENPGRLWLVLTAIRELGLENH--VLEPSPIGEELIYRIHEREYVE--------KI 66
D++HPE P R+ ++ + ELGL L P P E + H EYV K
Sbjct: 497 DSHHPEVPQRILRIMCRLEELGLAGRCLTLTPRPATEAELLTCHSAEYVGHLRATEKMKT 556
Query: 67 RELSRRGGGYLDADTYVSPRTWEAAILALGASRLATLSALRYGGMN-LALVRPPGHHAGR 125
REL R + Y+ P T+ A LA GA+ + L +N A+VRPPGHHA +
Sbjct: 557 RELHRESSNF--DSIYICPSTFACAQLATGAACRLVEAVLSGEVLNGAAVVRPPGHHAEQ 614
Query: 126 RGKALGAPTLGFCIFNNSAMAALTSKEETGKAL---VIDFDAHHGNGTQEIFWDDADVVH 182
GFC FN+ A+AA ++ +G AL ++D+D HHGNGTQ +F DD V++
Sbjct: 615 DAAC------GFCFFNSVAVAARHAQTISGHALRILIVDWDVHHGNGTQHMFEDDPSVLY 668
Query: 183 IDLHERD---IYPGSGDVG---EIGGINAKGSKINLPM--PHYSEDGDYIYAWEEVVIPI 234
+ LH D +P GD G +IG G +N+ P D DY+ AW +V+PI
Sbjct: 669 VSLHRYDHGTFFP-MGDEGASSQIGRAAGTGFTVNVAWNGPRMG-DADYLAAWHRLVLPI 726
Query: 235 VEEVKPKVVIVSAGFDGFKGDGLTTLKLTEVFYSYAGATLRKYP---LAVILEGGYS 288
E P++V+VSAGFD +GD L +++ Y++ L + +ILEGGY+
Sbjct: 727 AYEFNPELVLVSAGFDAARGDPLGGCQVSPEGYAHLTHLLMGLASGRIILILEGGYN 783
Score = 111 bits (274), Expect = 2e-23
Identities = 102/349 (29%), Positives = 159/349 (45%), Gaps = 44/349 (12%)
Query: 17 DNYHPENPGRLWLVLTAIRELGLENHVL--EPSPIGEELIYRIHEREYVEKIRELSRRGG 74
D+ PE P RL + + + GL + + + +E + +H EY++ +
Sbjct: 102 DDSFPEGPERLHAIKEQLIQEGLLDRCVSFQARFAEKEELMLVHSLEYIDLMETTQYMNE 161
Query: 75 GYLD--ADTYVS----PRTWEAAILALGAS-RL--ATLSALRYGGMNLALVRPPGHHAGR 125
G L ADTY S P ++ A LA G+ RL A L A GM A++RPPGHHA
Sbjct: 162 GELRVLADTYDSVYLHPNSYSCACLASGSVLRLVDAVLGAEIRNGM--AIIRPPGHHAQH 219
Query: 126 RGKALGAPTLGFCIFNNSAMAA--LTSKEETGKALVIDFDAHHGNGTQEIFWDDADVVHI 183
+ G+C+FN+ A+AA K + L++D+D HHG GTQ F D V++
Sbjct: 220 ------SLMDGYCMFNHVAVAARYAQQKHRIRRVLIVDWDVHHGQGTQFTFDQDPSVLYF 273
Query: 184 DLHERD---IYPG--SGDVGEIGGINAKGSKINLPMPHYS-EDGDYIYAWEEVVIPIVEE 237
+H + +P + + G +G IN+P D DYI A+ V++P+ E
Sbjct: 274 SIHRYEQGRFWPHLKASNWSTTGFGQGQGYTINVPWNQVGMRDADYIAAFLHVLLPVALE 333
Query: 238 VKPKVVIVSAGFDGFKGDGLTTL--------KLTEVFYSYAGATLRKYPLAVILEGGYS- 288
+P++V+V+AGFD +GD + +LT + AG L + LEGGY+
Sbjct: 334 FQPQLVLVAAGFDALQGDPKGEMAATPAGFAQLTHLLMGLAGG-----KLILSLEGGYNL 388
Query: 289 SGLKKGFPAFIRGYEED---KVRDHAQPSYETLKLVEEVKDILSPWWSL 334
L +G A + D + P V + L P+W +
Sbjct: 389 RALAEGVSASLHTLLGDPCPMLESPGAPCRSAQASVSCALEALEPFWEV 437
>pir||T46284 hypothetical protein DKFZp566E044.1 - human
>gi|6808055|emb|CAB70878.1| (AL137696) hypothetical
protein [Homo sapiens]
Length = 1063
Score = 151 bits (377), Expect = 1e-35
Identities = 106/297 (35%), Positives = 152/297 (50%), Gaps = 35/297 (11%)
Query: 17 DNYHPENPGRLWLVLTAIRELGLENH--VLEPSPIGEELIYRIHEREYVE--------KI 66
D++HPE P R+ ++ + ELGL L P P E + H EYV K
Sbjct: 345 DSHHPEVPQRILRIMCRLEELGLAGRCLTLTPRPATEAELLTCHSAEYVGHLRATEKMKT 404
Query: 67 RELSRRGGGYLDADTYVSPRTWEAAILALGASRLATLSALRYGGMN-LALVRPPGHHAGR 125
REL R + Y+ P T+ A LA GA+ + L +N A+VRPPGHHA +
Sbjct: 405 RELHRESSNF--DSIYICPSTFACAQLATGAACRLVEAVLSGEVLNGAAVVRPPGHHAEQ 462
Query: 126 RGKALGAPTLGFCIFNNSAMAALTSKEETGKAL---VIDFDAHHGNGTQEIFWDDADVVH 182
GFC FN+ A+AA ++ +G AL ++D+D HHGNGTQ +F DD V++
Sbjct: 463 DAAC------GFCFFNSVAVAARHAQTISGHALRILIVDWDVHHGNGTQHMFEDDPSVLY 516
Query: 183 IDLHERD---IYPGSGDVG---EIGGINAKGSKINLPM--PHYSEDGDYIYAWEEVVIPI 234
+ LH D +P GD G +IG G +N+ P D DY+ AW +V+PI
Sbjct: 517 VSLHRYDHGTFFP-MGDEGASSQIGRAAGTGFTVNVAWNGPRMG-DADYLAAWHRLVLPI 574
Query: 235 VEEVKPKVVIVSAGFDGFKGDGLTTLKLTEVFYSYAGATLRKYP---LAVILEGGYS 288
E P++V+VSAGFD +GD L +++ Y++ L + +ILEGGY+
Sbjct: 575 AYEFNPELVLVSAGFDAARGDPLGGCQVSPEGYAHLTHLLMGLASGRIILILEGGYN 631
Score = 101 bits (249), Expect = 1e-20
Identities = 88/283 (31%), Positives = 132/283 (46%), Gaps = 40/283 (14%)
Query: 79 ADTYVS----PRTWEAAILALGAS-RL--ATLSALRYGGMNLALVRPPGHHAGRRGKALG 131
ADTY S P ++ A LA G+ RL A L A GM A++RPPGHHA
Sbjct: 16 ADTYDSVYLHPNSYSCACLASGSVLRLVDAVLGAEIRNGM--AIIRPPGHHAQH------ 67
Query: 132 APTLGFCIFNNSAMAA--LTSKEETGKALVIDFDAHHGNGTQEIFWDDADVVHIDLHERD 189
+ G+C+FN+ A+AA K + L++D+D HHG GTQ F D V++ +H +
Sbjct: 68 SLMDGYCMFNHVAVAARYAQQKHRIRRVLIVDWDVHHGQGTQFTFDQDPSVLYFSIHRYE 127
Query: 190 ---IYPG--SGDVGEIGGINAKGSKINLPMPHYS-EDGDYIYAWEEVVIPIVEEVKPKVV 243
+P + + G +G IN+P D DYI A+ V++P+ E +P++V
Sbjct: 128 QGRFWPHLKASNWSTTGFGQGQGYTINVPWNQVGMRDADYIAAFLHVLLPVALEFQPQLV 187
Query: 244 IVSAGFDGFKGDGLTTL--------KLTEVFYSYAGATLRKYPLAVILEGGYS-SGLKKG 294
+V+AGFD +GD + +LT + AG L + LEGGY+ L +G
Sbjct: 188 LVAAGFDALQGDPKGEMAATPAGFAQLTHLLMGLAGG-----KLILSLEGGYNLRALAEG 242
Query: 295 FPAFIRGYEED---KVRDHAQPSYETLKLVEEVKDILSPWWSL 334
A + D + P V + L P+W +
Sbjct: 243 VSASLHTLLGDPCPMLESPGAPCRSAQTSVSCALEALEPFWEV 285
>dbj|BAB10370.1| (AB006696) contains similarity to histone deacetylase~gene_id:MAF19.8
[Arabidopsis thaliana]
Length = 1108
Score = 140 bits (349), Expect = 2e-32
Identities = 108/352 (30%), Positives = 168/352 (47%), Gaps = 35/352 (9%)
Query: 2 IGEIYYSRKFLLHKPDNY-HPENPGRLWLVLTAIRELGLENH--VLEPSPIGEELIYRIH 58
+G IY PD HPE P R+ ++ ++ G+ VL S ++ + +H
Sbjct: 703 VGLIYDETMCKHDTPDGEDHPECPDRIRVIWEKLQLAGVSQRCVVLGSSKAEDKHLQLVH 762
Query: 59 EREYVEKIRELSRRGGGYLDA-------DTYVSPRTWEAAILALGAS-RLATLSALRYGG 110
+++V ++ +S + Y Y++ + EAA LA G+ +LA A
Sbjct: 763 TKDHVNLVKSISTKQKDYRRNRIASQLNSIYLNGGSSEAAYLAAGSVVKLAEKVAEGELD 822
Query: 111 MNLALVRPPGHHAGRRGKALGAPTLGFCIFNNSAMAA---LTSKEETG--KALVIDFDAH 165
A+VRPPGHHA +GFC+FNN A+AA L + + G K L++D+D H
Sbjct: 823 CGFAIVRPPGHHAE------ADEAMGFCLFNNVAVAASFLLNERPDLGVKKILIVDWDVH 876
Query: 166 HGNGTQEIFWDDADVVHIDLHERD---IYPG--SGDVGEIGGINAKGSKINLPMPH-YSE 219
HGNGTQ++FW D V+ +H + YP GD +G +G IN+P
Sbjct: 877 HGNGTQKMFWKDPRVLFFSVHRHEYGGFYPAGDDGDYNMVGEGPGEGFNINVPWDQGRCG 936
Query: 220 DGDYIYAWEEVVIPIVEEVKPKVVIVSAGFDGFKGDGLTTLKLTEVFYSYAGATLRKY-- 277
D DY+ AW+ ++IP+ E P V+ +SAGFD D L +T YS L ++
Sbjct: 937 DADYLAAWDHILIPVAREFNPDVIFLSAGFDAAINDPLGGCCVTPYGYSVMLKKLMEFAQ 996
Query: 278 -PLAVILEGGYS-SGLKKGFPAFIRGYEEDKV---RDHAQPSYETLKLVEEV 324
+ + LEGGY+ + K A ++ EDK A P T ++++ V
Sbjct: 997 GKIVLALEGGYNLDSIAKSSLACVQVLLEDKQIQGPPEAYPFESTWRVIQAV 1048
Score = 138 bits (343), Expect = 1e-31
Identities = 103/340 (30%), Positives = 168/340 (49%), Gaps = 36/340 (10%)
Query: 22 ENPGRLWLVLTAIRELGLENH--VLEPSPIGEELIYRIHEREYVEKIRELSRRG------ 73
E P R+ ++ ++ G+ VL S ++ + +H +++V ++ +S +
Sbjct: 81 ECPDRIRVIWEKLQLAGVTQRCVVLGGSKAEDKHLKLVHTKKHVNLVKSISTKKKDSRRN 140
Query: 74 --GGYLDADTYVSPRTWEAAILALGAS-RLATLSALRYGGMNLALVRPPGHHAGRRGKAL 130
LD+ Y++ + EAA LA G+ ++A A A+VRPPGHHA
Sbjct: 141 KIASQLDS-IYLNGGSSEAAYLAAGSVVKVAEKVAEGELDCGFAIVRPPGHHAE------ 193
Query: 131 GAPTLGFCIFNNSAMAALTSKEE-----TGKALVIDFDAHHGNGTQEIFWDDADVVHIDL 185
+GFC+FNN A+AA E K L++D+D HHGNGTQ++FW D+ V+ +
Sbjct: 194 SDEAMGFCLFNNVAVAASFLLNERPDLDVKKILIVDWDIHHGNGTQKMFWKDSRVLIFSV 253
Query: 186 HERD---IYP--GSGDVGEIGGINAKGSKINLPMPHYS-EDGDYIYAWEEVVIPIVEEVK 239
H D YP GD +G +G IN+P D DY+ W ++IP+ +E K
Sbjct: 254 HRHDHGSFYPFGDDGDFNMVGEGPGEGFNINVPWEQGGCGDADYLAVWNHILIPVTKEFK 313
Query: 240 PKVVIVSAGFDGFKGDGLTTLKLTEVFYSYAGATLRKY---PLAVILEGGYS-SGLKKGF 295
P ++++SAGFD GD L +T YS L ++ + + LEGGY+ L K
Sbjct: 314 PDIILLSAGFDAAIGDPLGGCCVTPYGYSVMLKKLMEFAHGKIVLALEGGYNLESLGKSS 373
Query: 296 PAFIRGYEEDKVRDHAQPSY---ETLKLVEEVKDILSPWW 332
A ++ EDK + +Y T ++++ V++ L +W
Sbjct: 374 LACVQVLLEDKQIHGSSETYPLESTRRVIQAVRERLCTYW 413
>pir||D83174 probable acetylpolyamine aminohydrolase PA3774 [imported] -
Pseudomonas aeruginosa (strain PAO1)
>gi|9949945|gb|AAG07161.1|AE004796_6 (AE004796) probable
acetylpolyamine aminohydrolase [Pseudomonas aeruginosa]
Length = 380
Score = 136 bits (340), Expect = 3e-31
Identities = 87/256 (33%), Positives = 135/256 (51%), Gaps = 25/256 (9%)
Query: 48 PIGEELIYRIHEREYVEKIRELSRRGGGYLDADTYVSPRTWEAAILALGASRLATLSALR 107
P +E + R+H Y+E+ + LS GGG L D + P ++E A L+ G + +A L A+
Sbjct: 69 PASDEDLLRVHPAHYLERFKALSDAGGGSLGQDAPIGPGSYEIARLSAGLA-IAALDAVL 127
Query: 108 YGGMNLA--LVRPPGHHAGRRGKALGAPTLGFCIFNNSAMAALTSKEETG--KALVIDFD 163
G + A L RPPGHH L +GFC F N A+A +K G + V+D+D
Sbjct: 128 AGEADNAYSLSRPPGHHC------LPDQAMGFCFFANIAVAIEAAKARHGVERVAVLDWD 181
Query: 164 AHHGNGTQEIFWDDADVVHIDLHERDIYP----GSGDVGEIGGINAKGSKINLPMPHYSE 219
HHGNGTQ I++ DV+ I LH+ +P G+ D+GE G +G +N+P+
Sbjct: 182 VHHGNGTQAIYYRRDDVLSISLHQDGCFPPGYSGAEDIGEDRG---RGFNLNVPLLPGGG 238
Query: 220 DGDYIYAWEEVVIPIVEEVKPKVVIVSAGFDGFKGDGLTTLKLTEVFYSYAGATLRKYP- 278
Y+ A + +V+P +E +P++++V++GFD D L ++L + A +R
Sbjct: 239 HDAYMQAMQRIVLPALERFRPQLIVVASGFDANAVDPLARMQLHSDSFRAMTAMVRDAAE 298
Query: 279 ------LAVILEGGYS 288
L V+ EGGYS
Sbjct: 299 RHAGGRLVVVHEGGYS 314
>emb|CAB63048.1| (AL022328) dJ402G11.7 (novel protein similar to KIAA0901 and mouse
histone deacetylase MHDA2 (isoform 1)) [Homo sapiens]
Length = 673
Score = 135 bits (337), Expect = 6e-31
Identities = 100/288 (34%), Positives = 142/288 (48%), Gaps = 30/288 (10%)
Query: 22 ENPGRLWLVLTAIRELGLENHVLEPSP--IGEELIYRIHEREYVEKIRELSRRG------ 73
E P RL L +R+ GLE L S EE + +H EYV +RE G
Sbjct: 26 ERPERLTAALDRLRQRGLEQRCLRLSAREASEEELGLVHSPEYVSLVRETQVLGKEELQA 85
Query: 74 -GGYLDADTYVSPRTWEAAILALGASRLATLSALRYGGMN--LALVRPPGHHAGRRGKAL 130
G DA Y P T+ A LA GA L + A+ G + LALVRPPGHH R
Sbjct: 86 LSGQFDA-IYFHPSTFHCARLAAGAG-LQLVDAVLTGAVQNGLALVRPPGHHGQR----- 138
Query: 131 GAPTLGFCIFNNSAMAALTSKEETG--KALVIDFDAHHGNGTQEIFWDDADVVHIDLHER 188
A GFC+FNN A+AA +K++ G + LV+D+D HHG G Q +F DD V++ H
Sbjct: 139 -AAANGFCVFNNVAIAAAHAKQKHGLHRILVVDWDVHHGQGIQYLFEDDPSVLYFSWHRY 197
Query: 189 D---IYP--GSGDVGEIGGINAKGSKINLPMPHYS-EDGDYIYAWEEVVIPIVEEVKPKV 242
+ +P D +G G +NLP + DY+ A+ +++P+ E P++
Sbjct: 198 EHGRFWPFLRESDADAVGRGQGLGFTVNLPWNQVGMGNADYVAAFLHLLLPLAFEFDPEL 257
Query: 243 VIVSAGFDGFKGDGLTTLKLTEVFYSYAGATLRKYP---LAVILEGGY 287
V+VSAGFD GD ++ T +++ L+ + +LEGGY
Sbjct: 258 VLVSAGFDSAIGDPEGQMQATPECFAHLTQLLQVLAGGRVCAVLEGGY 305
>emb|CAB63049.1| (AL022328) dJ402G11.7 (novel protein similar to KIAA0901 and mouse
histone deacetylase MHDA2) [Homo sapiens]
Length = 662
Score = 135 bits (337), Expect = 6e-31
Identities = 100/288 (34%), Positives = 142/288 (48%), Gaps = 30/288 (10%)
Query: 22 ENPGRLWLVLTAIRELGLENHVLEPSP--IGEELIYRIHEREYVEKIRELSRRG------ 73
E P RL L +R+ GLE L S EE + +H EYV +RE G
Sbjct: 26 ERPERLTAALDRLRQRGLEQRCLRLSAREASEEELGLVHSPEYVSLVRETQVLGKEELQA 85
Query: 74 -GGYLDADTYVSPRTWEAAILALGASRLATLSALRYGGMN--LALVRPPGHHAGRRGKAL 130
G DA Y P T+ A LA GA L + A+ G + LALVRPPGHH R
Sbjct: 86 LSGQFDA-IYFHPSTFHCARLAAGAG-LQLVDAVLTGAVQNGLALVRPPGHHGQR----- 138
Query: 131 GAPTLGFCIFNNSAMAALTSKEETG--KALVIDFDAHHGNGTQEIFWDDADVVHIDLHER 188
A GFC+FNN A+AA +K++ G + LV+D+D HHG G Q +F DD V++ H
Sbjct: 139 -AAANGFCVFNNVAIAAAHAKQKHGLHRILVVDWDVHHGQGIQYLFEDDPSVLYFSWHRY 197
Query: 189 D---IYP--GSGDVGEIGGINAKGSKINLPMPHYS-EDGDYIYAWEEVVIPIVEEVKPKV 242
+ +P D +G G +NLP + DY+ A+ +++P+ E P++
Sbjct: 198 EHGRFWPFLRESDADAVGRGQGLGFTVNLPWNQVGMGNADYVAAFLHLLLPLAFEFDPEL 257
Query: 243 VIVSAGFDGFKGDGLTTLKLTEVFYSYAGATLRKYP---LAVILEGGY 287
V+VSAGFD GD ++ T +++ L+ + +LEGGY
Sbjct: 258 VLVSAGFDSAIGDPEGQMQATPECFAHLTQLLQVLAGGRVCAVLEGGY 305
>pir||T05998 hypothetical protein F17M5.230 - Arabidopsis thaliana
>gi|4490314|emb|CAB38805.1| (AL035678) putative protein
[Arabidopsis thaliana] >gi|7270295|emb|CAB80064.1|
(AL161583) putative protein [Arabidopsis thaliana]
Length = 359
Score = 134 bits (335), Expect = 1e-30
Identities = 95/349 (27%), Positives = 163/349 (46%), Gaps = 53/349 (15%)
Query: 20 HPENPGRLWLVLTAIRELGLENHVLEPSPIGEEL-------------IYRIHEREYV--- 63
HPE R+ ++ A LE + L P G ++ I +H++ YV
Sbjct: 15 HPECSARVPAIVNA-----LEMNELTPKFRGSQILELANFKTATVEDIANVHDKAYVFGL 69
Query: 64 -EKIRELSRRGGGYLDADTYVSPRTWEAAILALGASRLATLSALRYGGMNL--------- 113
+ + E S G +++ + A+ + + +A + ++ + +
Sbjct: 70 EKAMDEASDSGLIFIEGSGPTYATSTVTALCSSAGAGMALVDSVVMSRLTINSVDPPIGF 129
Query: 114 ALVRPPGHHAGRRGKALGAPTLGFCIFNNSAMAALTSKEETG--KALVIDFDAHHGNGTQ 171
AL+RPPGHHA +G +GFC+F N A+AA ++ G + +IDFD HHGNGT
Sbjct: 130 ALIRPPGHHAVPKGP------MGFCVFGNVAIAARHAQRTHGLKRIFIIDFDVHHGNGTN 183
Query: 172 EIFWDDADVVHIDLHERDIYPGSGDVGEIGGINAKGSKINLPMPHYSEDGDYIYAWEEVV 231
+ F +D D+ + H+ YPG+G + +IG +G+ +NLP+P S D +EE++
Sbjct: 184 DAFTEDPDIFFLSTHQDGSYPGTGKISDIGKGKGEGTTLNLPLPGGSGDIAMRTVFEEII 243
Query: 232 IPIVEEVKPKVVIVSAGFDGFKGDGLTTLKLTEVFYSYAGATLRKYPLAV-------ILE 284
+P + KP +++VSAG+D D L L+ T Y +++ V LE
Sbjct: 244 VPCAQRFKPDIILVSAGYDAHVLDPLANLQFTTATYYSLAKDIKRLAKEVCGGRCVFFLE 303
Query: 285 GGY-----SSGLKKGFPAFIRGYEEDKVRDHAQPSYETLKLVEEVKDIL 328
GGY SS + F A + E+ + P+Y + + +V+D +
Sbjct: 304 GGYNLESLSSSVADSFRALLG--EDSLASEFDNPAYLYDEPMRKVRDAI 350
>gi|6324307 histone deacetylase, shares sequence similarity with Rpd3p, Hos1p,
Hos2p, and Hos3p; Hda1p [Saccharomyces cerevisiae]
>gi|1730711|sp|P53973|HDA1_YEAST HISTONE DEACETYLASE
HDA1 >gi|2131864|pir||S62933 hypothetical protein
YNL021w - yeast (Saccharomyces cerevisiae)
>gi|1301851|emb|CAA95883.1| (Z71297) ORF YNL021w
[Saccharomyces cerevisiae]
Length = 706
Score = 134 bits (334), Expect = 1e-30
Identities = 104/356 (29%), Positives = 175/356 (48%), Gaps = 51/356 (14%)
Query: 20 HPENPGRLWLVLTAIRELGLENHVLEPSPIG-----------------EELIYRIHEREY 62
HPE+P R++ + + E GL N +P+ G E I +H +E+
Sbjct: 83 HPEDPRRIYRIYKILAENGLIN---DPTLSGVDDLGDLMLKIPVRAATSEEILEVHTKEH 139
Query: 63 VEKIRELSRRGGGYLDADT------YVSPRTWEAAILALGASRLATLSALRYGGMN-LAL 115
+E I + L +T Y + ++ +A L G + A + + N LA+
Sbjct: 140 LEFIESTEKMSREELLKETEKGDSVYFNNDSYASARLPCGGAIEACKAVVEGRVKNSLAV 199
Query: 116 VRPPGHHAGRRGKALGAPTLGFCIFNNSAMAALTS----KEETGKALVIDFDAHHGNGTQ 171
VRPPGHHA +A G GFC+F+N A+AA E + +++D+D HHGNGTQ
Sbjct: 200 VRPPGHHA--EPQAAG----GFCLFSNVAVAAKNILKNYPESVRRIMILDWDIHHGNGTQ 253
Query: 172 EIFWDDADVVHIDLHERDI---YPGS--GDVGEIGGINAKGSKINLPMPHYSE-DGDYIY 225
+ F+ D V+++ LH ++ YPG+ G + G +G N+ P D +Y++
Sbjct: 254 KSFYQDDQVLYVSLHRFEMGKYYPGTIQGQYDQTGEGKGEGFNCNITWPVGGVGDAEYMW 313
Query: 226 AWEEVVIPIVEEVKPKVVIVSAGFDGFKGDGLTTLKLTEVFYSYAGATLRKYP---LAVI 282
A+E+VV+P+ E KP +VI+S+GFD GD + +T Y + L+ L V+
Sbjct: 314 AFEQVVMPMGREFKPDLVIISSGFDAADGDTIGQCHVTPSCYGHMTHMLKSLARGNLCVV 373
Query: 283 LEGGYS----SGLKKGFPAFIRGYEEDKVRDH-AQPSYETLKLVEEVKDILSPWWS 333
LEGGY+ + + G D++ D + P E ++++++V + S +W+
Sbjct: 374 LEGGYNLDAIARSALSVAKVLIGEPPDELPDPLSDPKPEVIEMIDKVIRLQSKYWN 429
>sp|P56523|HDA1_SCHPO HISTONE DEACETYLASE CLR3 >gi|11359242|pir||T43797 probable histone
deacetylase (EC 3.5.1.-) clr3 - fission yeast
(Schizosaccharomyces pombe) >gi|4159999|gb|AAD05212.1|
(AF064207) putative histone deacetylase
[Schizosaccharomyces pombe] >gi|9716243|emb|CAC01518.1|
(AL391034) putative histone deacetylase
[Schizosaccharomyces pombe]
Length = 687
Score = 132 bits (330), Expect = 4e-30
Identities = 98/303 (32%), Positives = 152/303 (49%), Gaps = 45/303 (14%)
Query: 20 HPENPGRLWLVLTAIRELGLENHVLEPSPIG----------EELIYRIHEREYVEKIREL 69
HPE+P R+ V AI++ G ++V PS + EEL+ ++H +E +++
Sbjct: 77 HPEDPRRVLRVFEAIKKAGYVSNVPSPSDVFLRIPAREATLEELL-QVHSQEMYDRVTNT 135
Query: 70 SRRGGGYL------DADTYVSPRTWEAAILALGASRLATLSALRYGGMN--LALVRPPGH 121
+ L Y + + A LA G S + T +A+ G + A+VRPPGH
Sbjct: 136 EKMSHEDLANLEKISDSLYYNNESAFCARLACG-SAIETCTAVVTGQVKNAFAVVRPPGH 194
Query: 122 HAGRRGKALGAPTLGFCIFNNSAMAALTS----KEETGKALVIDFDAHHGNGTQEIFWDD 177
HA GFC+FNN ++ A + ++ + L++D+D HHGNGTQ F+DD
Sbjct: 195 HAEPHKPG------GFCLFNNVSVTARSMLQRFPDKIKRVLIVDWDIHHGNGTQMAFYDD 248
Query: 178 ADVVHIDLHERD---IYPGSG-----DVGEIGGINAKGSKINLPMPHYSE-DGDYIYAWE 228
+V+++ LH + YPG+ + GE G+ G +N+P DGDYIYA++
Sbjct: 249 PNVLYVSLHRYENGRFYPGTNYGCAENCGEGPGL---GRTVNIPWSCAGMGDGDYIYAFQ 305
Query: 229 EVVIPIVEEVKPKVVIVSAGFDGFKGDGLTTLKLTEVFYSYAGATLRKY---PLAVILEG 285
VV+P+ E P +VIVS GFD GD + LT Y++ L + + LEG
Sbjct: 306 RVVMPVAYEFDPDLVIVSCGFDAAAGDHIGQFLLTPAAYAHMTQMLMGLADGKVFISLEG 365
Query: 286 GYS 288
GY+
Sbjct: 366 GYN 368
>gb|AAD21090.1| (AF129433) histone deacetylase HDA2 [Drosophila melanogaster]
>gi|7293057|gb|AAF48443.1| (AE003498) HDAC2 gene product
[Drosophila melanogaster]
Length = 883
Score = 132 bits (330), Expect = 4e-30
Identities = 103/304 (33%), Positives = 151/304 (48%), Gaps = 28/304 (9%)
Query: 7 YSRKFLLH--KPDNYHPENPGRLWLVLTAIRELGLENHV--LEPSPIGEELIYRIHEREY 62
Y + LLH D HPE P R+ + + GL + L P + + H R +
Sbjct: 463 YDAQMLLHCNLNDTGHPEQPSRIQHIHKMHDDYGLLKQMKQLSPRAATTDEVCLAHTRAH 522
Query: 63 VEKIRELSRRGGGYL-DA-----DTYVSPRTWEAAILALGASRLATLSALRYGGMN-LAL 115
V +R L R L DA Y+ PRT++ A LA G A S LR + +
Sbjct: 523 VNTVRRLLGREPKELHDAAGIYNSVYLHPRTFDCATLAAGLVLQAVDSVLRGESRSGICN 582
Query: 116 VRPPGHHAGRRGKALGAPTLGFCIFNNSAMAALTSKEETG--KALVIDFDAHHGNGTQEI 173
VRPPGHHA + GFCIFNN A+AA + + G + L++D+D HHGNGTQ I
Sbjct: 583 VRPPGHHAEQDHPH------GFCIFNNVAIAAQYAIRDFGLERVLIVDWDVHHGNGTQHI 636
Query: 174 FWDDADVVHIDLHERD---IYP--GSGDVGEIGGINAKGSKINLPMPHYS-EDGDYIYAW 227
F + V++I LH + +P G+ +G +G +N+P D +Y A+
Sbjct: 637 FESNPKVLYISLHRYEHGSFFPKGPDGNFDVVGKGAGRGFNVNIPWNKKGMGDLEYALAF 696
Query: 228 EEVVIPIVEEVKPKVVIVSAGFDGFKGDGLTTLKLTEVFY---SYAGATLRKYPLAVILE 284
+++++PI E P++V+VSAGFD GD L K+T Y ++ + L + V LE
Sbjct: 697 QQLIMPIAYEFNPQLVLVSAGFDAAIGDPLGGCKVTAEGYGMLTHWLSALASGRIIVCLE 756
Query: 285 GGYS 288
GGY+
Sbjct: 757 GGYN 760
Score = 127 bits (317), Expect = 1e-28
Identities = 101/330 (30%), Positives = 160/330 (47%), Gaps = 40/330 (12%)
Query: 17 DNYHPENPGRLWLVLTAIRELGLENHVLE-PSPIG-EELIYRIHEREYVEKIRELSRRGG 74
D H E P R VL REL L LE PS ++ I R+H E+ E+++E S
Sbjct: 47 DKEHYECPERFTRVLERCRELNLTERCLELPSRSATKDEILRLHTEEHFERLKETS---- 102
Query: 75 GYLDADT-----------YVSPRTWEAAILALGAS-RLATLSALRYGGMNLALVRPPGHH 122
G D + Y+ P T+E ++LA G++ L +A++RPPGHH
Sbjct: 103 GIRDDERMEELSSRYDSIYIHPSTFELSLLASGSTIELVDHLVAGKAQNGMAIIRPPGHH 162
Query: 123 AGRRGKALGAPTLGFCIFNNSAMAALTSKE--ETGKALVIDFDAHHGNGTQEIFWDDADV 180
A + A G+C FNN A+A + + + + L+ID+D HHG GTQ F++D V
Sbjct: 163 A------MKAEYNGYCFFNNVALATQHALDVHKLQRILIIDYDVHHGQGTQRFFYNDPRV 216
Query: 181 VHIDLHERD---IYP--GSGDVGEIGGINAKGSKINLPMPHYS-EDGDYIYAWEEVVIPI 234
V+ +H + +P D IG G N+P+ +GDY+ ++++++P+
Sbjct: 217 VYFSIHRFEHGSFWPHLHESDYHAIGSGAGTGYNFNVPLNATGMTNGDYLAIFQQLLLPV 276
Query: 235 VEEVKPKVVIVSAGFDGFKGDGLTTLKLTEVFYSYAGATLRKYP---LAVILEGGYS-SG 290
E +P+++IVSAG+D G +++T Y + L + +AV+LEGGY
Sbjct: 277 ALEFQPELIIVSAGYDAALGCPEGEMEVTPACYPHLLNPLLRLADARVAVVLEGGYCLDS 336
Query: 291 LKKGFPAFIRGYEEDKVRDHAQPSYETLKL 320
L +G +R + D P ET+ L
Sbjct: 337 LAEGAALTLRSL----LGDPCPPLVETVPL 362
>sp|Q20296|YLFN_CAEEL HYPOTHETICAL 89.8 KD PROTEIN F41H10.6 IN CHROMOSOME IV
Length = 798
Score = 131 bits (325), Expect = 2e-29
Identities = 102/355 (28%), Positives = 173/355 (48%), Gaps = 43/355 (12%)
Query: 17 DNYHPENPGRLWLVLTAIRELGLENHVLEPSP---IGEELIYRIHEREYVEKIRELSRRG 73
++ HPE P R +L +RE G+ ++ + E I +H ++ +E +R
Sbjct: 443 EDNHPEKPARTRRILKTLRESGVLEKCVDRNCERIATNEEIRLVHTKKMLEHLRTTETMK 502
Query: 74 GGYLDADT-------YVSPRTWEAAILALGA--SRLATLSALRYGGMN-LALVRPPGHHA 123
L + Y++ T + A A+GA + + G N L +VRPPGHHA
Sbjct: 503 DEELMEEAEKEFNSIYLTRDTLKVARKAVGAVLQSVDEIFEKDAGQRNALVIVRPPGHHA 562
Query: 124 GRRGKALGAPTLGFCIFNNSAMAALTS--KEETGKALVIDFDAHHGNGTQEIFWDDADVV 181
+ + GFCIFNN A+AA + + + + L++D+D HHGNGTQEIF++D++V+
Sbjct: 563 S------ASKSSGFCIFNNVAVAAKYAQRRHKAKRVLILDWDVHHGNGTQEIFYEDSNVM 616
Query: 182 HIDLHERD---IYP--GSGDVGEIGGINAKGSKINLPMPHYS-EDGDYIYAWEEVVIPIV 235
++ +H D YP D ++G +G +N+P D +Y A++ V++PI
Sbjct: 617 YMSIHRHDKGNFYPIGEPKDYSDVGEGAGEGMSVNVPFSGVQMGDNEYQMAFQRVIMPIA 676
Query: 236 EEVKPKVVIVSAGFDGFKGDGLTTLKLT-EVF--YSYAGATLRKYPLAVILEGGYS-SGL 291
+ P +V++SAGFD D L K+T E F +Y ++L + +LEGGY+ + +
Sbjct: 677 YQFNPDLVLISAGFDAAVDDPLGEYKVTPETFALMTYQLSSLAGGRIITVLEGGYNLTSI 736
Query: 292 KKGFPA---------FIRGYEEDKVRDHAQP---SYETLKLVEEVKDILSPWWSL 334
A +R E+K + +P +K + EV + +WS+
Sbjct: 737 SNSAQAVCEVLQNRSMLRRLREEKEQFATKPQKIESSCIKTIREVCAVQQKYWSI 791
Score = 106 bits (262), Expect = 4e-22
Identities = 74/234 (31%), Positives = 109/234 (45%), Gaps = 20/234 (8%)
Query: 114 ALVRPPGHHAGRRGKALGAPTLGFCIFNNSAMAALTSK-EETGKALVIDFDAHHGNGTQE 172
A+VRPPGHHA GFC+FNN A AA + + L++D D HHG+GTQ
Sbjct: 138 AVVRPPGHHAD------SVSPCGFCLFNNVAQAAEEAFFSGAERILIVDLDVHHGHGTQR 191
Query: 173 IFWDDADVVHIDLHERD---IYP--GSGDVGEIGGINAKGSKINLPMPHYS-EDGDYIYA 226
IF+DD V++ +H + +P D IG G NL + D DY+
Sbjct: 192 IFYDDKRVLYFSIHRHEHGLFWPHLPESDFDHIGSGKGLGYNANLALNETGCTDSDYLSI 251
Query: 227 WEEVVIPIVEEVKPKVVIVSAGFDGFKGDGLTTLKLTEVFYS---YAGATLRKYPLAVIL 283
V++P+ + P VI+SAGFD GD L + LT YS Y +L + + V+L
Sbjct: 252 IFHVLLPLATQFDPHFVIISAGFDALLGDPLGGMCLTPDGYSHILYHLKSLAQGRMLVVL 311
Query: 284 EGGYSSGLK----KGFPAFIRGYEEDKVRDHAQPSYETLKLVEEVKDILSPWWS 333
EGGY+ + + + GY + + P T+ + +L W+
Sbjct: 312 EGGYNHQISAVAVQRCVRVLLGYAPFSIELNEAPKESTVDSCVSLVSVLRHHWN 365
>gb|AAD31553.1|U61954_9 (U61954) similar to bacillus subtilis acetoin utilization ACUC
protein (SP:P39067) [Caenorhabditis elegans]
Length = 863
Score = 131 bits (325), Expect = 2e-29
Identities = 102/355 (28%), Positives = 173/355 (48%), Gaps = 43/355 (12%)
Query: 17 DNYHPENPGRLWLVLTAIRELGLENHVLEPSP---IGEELIYRIHEREYVEKIRELSRRG 73
++ HPE P R +L +RE G+ ++ + E I +H ++ +E +R
Sbjct: 443 EDNHPEKPARTRRILKTLRESGVLEKCVDRNCERIATNEEIRLVHTKKMLEHLRTTETMK 502
Query: 74 GGYLDADT-------YVSPRTWEAAILALGA--SRLATLSALRYGGMN-LALVRPPGHHA 123
L + Y++ T + A A+GA + + G N L +VRPPGHHA
Sbjct: 503 DEELMEEAEKEFNSIYLTRDTLKVARKAVGAVLQSVDEIFEKDAGQRNALVIVRPPGHHA 562
Query: 124 GRRGKALGAPTLGFCIFNNSAMAALTS--KEETGKALVIDFDAHHGNGTQEIFWDDADVV 181
+ + GFCIFNN A+AA + + + + L++D+D HHGNGTQEIF++D++V+
Sbjct: 563 S------ASKSSGFCIFNNVAVAAKYAQRRHKAKRVLILDWDVHHGNGTQEIFYEDSNVM 616
Query: 182 HIDLHERD---IYP--GSGDVGEIGGINAKGSKINLPMPHYS-EDGDYIYAWEEVVIPIV 235
++ +H D YP D ++G +G +N+P D +Y A++ V++PI
Sbjct: 617 YMSIHRHDKGNFYPIGEPKDYSDVGEGAGEGMSVNVPFSGVQMGDNEYQMAFQRVIMPIA 676
Query: 236 EEVKPKVVIVSAGFDGFKGDGLTTLKLT-EVF--YSYAGATLRKYPLAVILEGGYS-SGL 291
+ P +V++SAGFD D L K+T E F +Y ++L + +LEGGY+ + +
Sbjct: 677 YQFNPDLVLISAGFDAAVDDPLGEYKVTPETFALMTYQLSSLAGGRIITVLEGGYNLTSI 736
Query: 292 KKGFPA---------FIRGYEEDKVRDHAQP---SYETLKLVEEVKDILSPWWSL 334
A +R E+K + +P +K + EV + +WS+
Sbjct: 737 SNSAQAVCEVLQNRSMLRRLREEKEQFATKPQKIESSCIKTIREVCAVQQKYWSI 791
Score = 106 bits (262), Expect = 4e-22
Identities = 74/234 (31%), Positives = 109/234 (45%), Gaps = 20/234 (8%)
Query: 114 ALVRPPGHHAGRRGKALGAPTLGFCIFNNSAMAALTSK-EETGKALVIDFDAHHGNGTQE 172
A+VRPPGHHA GFC+FNN A AA + + L++D D HHG+GTQ
Sbjct: 138 AVVRPPGHHAD------SVSPCGFCLFNNVAQAAEEAFFSGAERILIVDLDVHHGHGTQR 191
Query: 173 IFWDDADVVHIDLHERD---IYP--GSGDVGEIGGINAKGSKINLPMPHYS-EDGDYIYA 226
IF+DD V++ +H + +P D IG G NL + D DY+
Sbjct: 192 IFYDDKRVLYFSIHRHEHGLFWPHLPESDFDHIGSGKGLGYNANLALNETGCTDSDYLSI 251
Query: 227 WEEVVIPIVEEVKPKVVIVSAGFDGFKGDGLTTLKLTEVFYS---YAGATLRKYPLAVIL 283
V++P+ + P VI+SAGFD GD L + LT YS Y +L + + V+L
Sbjct: 252 IFHVLLPLATQFDPHFVIISAGFDALLGDPLGGMCLTPDGYSHILYHLKSLAQGRMLVVL 311
Query: 284 EGGYSSGLK----KGFPAFIRGYEEDKVRDHAQPSYETLKLVEEVKDILSPWWS 333
EGGY+ + + + GY + + P T+ + +L W+
Sbjct: 312 EGGYNHQISAVAVQRCVRVLLGYAPFSIELNEAPKESTVDSCVSLVSVLRHHWN 365
>gb|AAD31554.1|U61954_10 (U61954) similar to bacillus subtilis acetoin utilization ACUC
protein (SP:P39067) [Caenorhabditis elegans]
Length = 1012
Score = 131 bits (325), Expect = 2e-29
Identities = 102/355 (28%), Positives = 173/355 (48%), Gaps = 43/355 (12%)
Query: 17 DNYHPENPGRLWLVLTAIRELGLENHVLEPSP---IGEELIYRIHEREYVEKIRELSRRG 73
++ HPE P R +L +RE G+ ++ + E I +H ++ +E +R
Sbjct: 443 EDNHPEKPARTRRILKTLRESGVLEKCVDRNCERIATNEEIRLVHTKKMLEHLRTTETMK 502
Query: 74 GGYLDADT-------YVSPRTWEAAILALGA--SRLATLSALRYGGMN-LALVRPPGHHA 123
L + Y++ T + A A+GA + + G N L +VRPPGHHA
Sbjct: 503 DEELMEEAEKEFNSIYLTRDTLKVARKAVGAVLQSVDEIFEKDAGQRNALVIVRPPGHHA 562
Query: 124 GRRGKALGAPTLGFCIFNNSAMAALTS--KEETGKALVIDFDAHHGNGTQEIFWDDADVV 181
+ + GFCIFNN A+AA + + + + L++D+D HHGNGTQEIF++D++V+
Sbjct: 563 S------ASKSSGFCIFNNVAVAAKYAQRRHKAKRVLILDWDVHHGNGTQEIFYEDSNVM 616
Query: 182 HIDLHERD---IYP--GSGDVGEIGGINAKGSKINLPMPHYS-EDGDYIYAWEEVVIPIV 235
++ +H D YP D ++G +G +N+P D +Y A++ V++PI
Sbjct: 617 YMSIHRHDKGNFYPIGEPKDYSDVGEGAGEGMSVNVPFSGVQMGDNEYQMAFQRVIMPIA 676
Query: 236 EEVKPKVVIVSAGFDGFKGDGLTTLKLT-EVF--YSYAGATLRKYPLAVILEGGYS-SGL 291
+ P +V++SAGFD D L K+T E F +Y ++L + +LEGGY+ + +
Sbjct: 677 YQFNPDLVLISAGFDAAVDDPLGEYKVTPETFALMTYQLSSLAGGRIITVLEGGYNLTSI 736
Query: 292 KKGFPA---------FIRGYEEDKVRDHAQP---SYETLKLVEEVKDILSPWWSL 334
A +R E+K + +P +K + EV + +WS+
Sbjct: 737 SNSAQAVCEVLQNRSMLRRLREEKEQFATKPQKIESSCIKTIREVCAVQQKYWSI 791
Score = 106 bits (262), Expect = 4e-22
Identities = 74/234 (31%), Positives = 109/234 (45%), Gaps = 20/234 (8%)
Query: 114 ALVRPPGHHAGRRGKALGAPTLGFCIFNNSAMAALTSK-EETGKALVIDFDAHHGNGTQE 172
A+VRPPGHHA GFC+FNN A AA + + L++D D HHG+GTQ
Sbjct: 138 AVVRPPGHHAD------SVSPCGFCLFNNVAQAAEEAFFSGAERILIVDLDVHHGHGTQR 191
Query: 173 IFWDDADVVHIDLHERD---IYP--GSGDVGEIGGINAKGSKINLPMPHYS-EDGDYIYA 226
IF+DD V++ +H + +P D IG G NL + D DY+
Sbjct: 192 IFYDDKRVLYFSIHRHEHGLFWPHLPESDFDHIGSGKGLGYNANLALNETGCTDSDYLSI 251
Query: 227 WEEVVIPIVEEVKPKVVIVSAGFDGFKGDGLTTLKLTEVFYS---YAGATLRKYPLAVIL 283
V++P+ + P VI+SAGFD GD L + LT YS Y +L + + V+L
Sbjct: 252 IFHVLLPLATQFDPHFVIISAGFDALLGDPLGGMCLTPDGYSHILYHLKSLAQGRMLVVL 311
Query: 284 EGGYSSGLK----KGFPAFIRGYEEDKVRDHAQPSYETLKLVEEVKDILSPWWS 333
EGGY+ + + + GY + + P T+ + +L W+
Sbjct: 312 EGGYNHQISAVAVQRCVRVLLGYAPFSIELNEAPKESTVDSCVSLVSVLRHHWN 365
>pir||T32425 hypothetical protein C10E2.3 - Caenorhabditis elegans
>gi|2435529|gb|AAB71243.1| (AF026202) contains
similarity to S. cerevisiae transcriptional regulatory
protein RPD3 (SP:P32561) [Caenorhabditis elegans]
Length = 796
Score = 127 bits (317), Expect = 1e-28
Identities = 80/230 (34%), Positives = 120/230 (51%), Gaps = 21/230 (9%)
Query: 73 GGGYLDADTYVSPRTWEAAILALGASRLATLSALRYGGMN--LALVRPPGHHAGRRGKAL 130
GG +D+DTY + + + A + + S + G + A +RPPGHHA
Sbjct: 487 GGIGVDSDTYFNDASTQTAARLAAGTLIELSSQVAEGRLKNGFACIRPPGHHAEHE---- 542
Query: 131 GAPTLGFCIFNNSAMAA--LTSK--EETGKALVIDFDAHHGNGTQEIFWDDADVVHIDLH 186
+GFC FNN A+A L +K + K +ID+D HHGNGTQ F +D +V+++ LH
Sbjct: 543 --QAMGFCFFNNVAVAVKVLQTKYPAQCAKIAIIDWDVHHGNGTQLSFENDPNVLYMSLH 600
Query: 187 ERD---IYPGSGDVGEIGGINAKGSKINLPMP-HYSEDGDYIYAWEEVVIPIVEEVKPKV 242
D +PG+G V E+G +AKG +N+P D +Y+ AW V+ P++ P
Sbjct: 601 RHDKGNFFPGTGSVTEVGKNDAKGLTVNVPFSGDVMRDPEYLAAWRTVIEPVMASFCPDF 660
Query: 243 VIVSAGFDGFKG--DGLTTLKLTEVFYSYAGATLRKY---PLAVILEGGY 287
+IVSAGFD G + L ++T + Y +L Y + + LEGGY
Sbjct: 661 IIVSAGFDACHGHPNALGGYEVTPEMFGYMTKSLLNYASGKVVLALEGGY 710
>gb|AAF22892.1|AC006932_9 (AC006932) T27G7.14 [Arabidopsis thaliana]
Length = 425
Score = 127 bits (316), Expect = 2e-28
Identities = 86/250 (34%), Positives = 130/250 (51%), Gaps = 33/250 (13%)
Query: 20 HPENPGRLWLVLTAIRELGLENHVLE----PSPIGEELIYRIHEREYVEKIRELSRRGGG 75
HPEN R+ +L+ +R + HV P+ + E L++ H EY+EK+ E + G
Sbjct: 39 HPENADRVRNMLSILRRGPIAPHVNWFTGLPAIVSELLMF--HTSEYIEKLVEADKSGER 96
Query: 76 Y-LDADTYVSPRTWEAAILALGASRLATLSALRY-----GGMNLALVRPPGHHAGRRGKA 129
+ A T++SP +WEAA+LA G TLSA+++ G + ALVRPPGHH+
Sbjct: 97 CEIAAGTFMSPGSWEAALLAAGT----TLSAMQHILDCHGKIAYALVRPPGHHS------ 146
Query: 130 LGAPTL--GFCIFNNSAMAA--LTSKEETGKALVIDFDAHHGNGTQEIFWDDADVVHIDL 185
PT G+C NN+A+A + + VID D H+GNGT E F+ V+ + L
Sbjct: 147 --QPTQADGYCFLNNAALAVKLALNSGSCSRVAVIDIDVHYGNGTAEGFYTSDKVLTVSL 204
Query: 186 HER-----DIYPGSGDVGEIGGINAKGSKINLPMPHYSEDGDYIYAWEEVVIPIVEEVKP 240
H +P G + E+G G +N+P+P+ + D Y YA E+V+P V P
Sbjct: 205 HMNHGSWGSSHPQKGSIDELGEDVGLGYNLNVPLPNGTGDRGYEYAMNELVVPAVRRFGP 264
Query: 241 KVVIVSAGFD 250
+V++ G D
Sbjct: 265 DMVVLVVGQD 274
>pir||T17245 hypothetical protein DKFZp586J0917.1 - human (fragment)
>gi|5911907|emb|CAB55935.1| (AL117455) hypothetical
protein [Homo sapiens]
Length = 878
Score = 122 bits (303), Expect = 6e-27
Identities = 101/361 (27%), Positives = 165/361 (44%), Gaps = 54/361 (14%)
Query: 20 HPENPGRLWLVLTAIRELGLENHV--LEPSPIGEELIYRIHEREYV-------------- 63
HPE+ GR+ + + ++E GL + L E + +H +V
Sbjct: 467 HPEHAGRIQSIWSRLQERGLRSQCECLRGRKASLEELQSVHSERHVLLYGTNPLSRLKLD 526
Query: 64 ---------EKIRELSRRGGGYLDADTYVSP-RTWEAAILALGA-SRLATLSALRYGGMN 112
+++ + GG +D DT + + AA A G+ + LA A R
Sbjct: 527 NGKLAGLLAQRMFVMLPCGGVGVDTDTIWNELHSSNAARWAAGSVTDLAFKVASRELKNG 586
Query: 113 LALVRPPGHHAGRRGKALGAPTLGFCIFNNSAMAA--LTSKEETGKALVIDFDAHHGNGT 170
A+VRPPGHHA + +GFC FN+ A+A L + + K L++D+D HHGNGT
Sbjct: 587 FAVVRPPGHHADH------STAMGFCFFNSVAIACRQLQQQSKASKILIVDWDVHHGNGT 640
Query: 171 QEIFWDDADVVHIDLHERD---IYPGSGDVGEIGGINAKGSKINLP----MPHYSEDGDY 223
Q+ F+ D V++I LH D +PGSG V E+G + +G +N+ + D +Y
Sbjct: 641 QQTFYQDPSVLYISLHRHDDGNFFPGSGAVDEVGAGSGEGFNVNVAWAGGLDPPMGDPEY 700
Query: 224 IYAWEEVVIPIVEEVKPKVVIVSAGFDGFKGD--GLTTLKLTEVFYSYAGATLRKY---P 278
+ A+ VV+PI E P +V+VSAGFD +G L ++ + Y L
Sbjct: 701 LAAFRIVVMPIAREFSPDLVLVSAGFDAAEGHPAPLGGYHVSAKCFGYMTQQLMNLAGGA 760
Query: 279 LAVILEGGYS----SGLKKGFPAFIRGYEEDKVRDHA---QPSYETLKLVEEVKDILSPW 331
+ + LEGG+ + A + G D + + +P+ ++ +E V + S +
Sbjct: 761 VVLALEGGHDLTAICDASEACVAALLGNRVDPLSEEGWKQKPNLNAIRSLEAVIRVHSKY 820
Query: 332 W 332
W
Sbjct: 821 W 821
>gi|11436703 histone deacetylase 7 [Homo sapiens]
Length = 912
Score = 122 bits (303), Expect = 6e-27
Identities = 101/361 (27%), Positives = 165/361 (44%), Gaps = 54/361 (14%)
Query: 20 HPENPGRLWLVLTAIRELGLENHV--LEPSPIGEELIYRIHEREYV-------------- 63
HPE+ GR+ + + ++E GL + L E + +H +V
Sbjct: 501 HPEHAGRIQSIWSRLQERGLRSQCECLRGRKASLEELQSVHSERHVLLYGTNPLSRLKLD 560
Query: 64 ---------EKIRELSRRGGGYLDADTYVSP-RTWEAAILALGA-SRLATLSALRYGGMN 112
+++ + GG +D DT + + AA A G+ + LA A R
Sbjct: 561 NGKLAGLLAQRMFVMLPCGGVGVDTDTIWNELHSSNAARWAAGSVTDLAFKVASRELKNG 620
Query: 113 LALVRPPGHHAGRRGKALGAPTLGFCIFNNSAMAA--LTSKEETGKALVIDFDAHHGNGT 170
A+VRPPGHHA + +GFC FN+ A+A L + + K L++D+D HHGNGT
Sbjct: 621 FAVVRPPGHHADH------STAMGFCFFNSVAIACRQLQQQSKASKILIVDWDVHHGNGT 674
Query: 171 QEIFWDDADVVHIDLHERD---IYPGSGDVGEIGGINAKGSKINLP----MPHYSEDGDY 223
Q+ F+ D V++I LH D +PGSG V E+G + +G +N+ + D +Y
Sbjct: 675 QQTFYQDPSVLYISLHRHDDGNFFPGSGAVDEVGAGSGEGFNVNVAWAGGLDPPMGDPEY 734
Query: 224 IYAWEEVVIPIVEEVKPKVVIVSAGFDGFKGD--GLTTLKLTEVFYSYAGATLRKY---P 278
+ A+ VV+PI E P +V+VSAGFD +G L ++ + Y L
Sbjct: 735 LAAFRIVVMPIAREFSPDLVLVSAGFDAAEGHPAPLGGYHVSAKCFGYMTQQLMNLAGGA 794
Query: 279 LAVILEGGYS----SGLKKGFPAFIRGYEEDKVRDHA---QPSYETLKLVEEVKDILSPW 331
+ + LEGG+ + A + G D + + +P+ ++ +E V + S +
Sbjct: 795 VVLALEGGHDLTAICDASEACVAALLGNRVDPLSEEGWKQKPNLNAIRSLEAVIRVHSKY 854
Query: 332 W 332
W
Sbjct: 855 W 855
>dbj|BAA91545.1| (AK001190) unnamed protein product [Homo sapiens]
Length = 614
Score = 122 bits (303), Expect = 6e-27
Identities = 101/361 (27%), Positives = 165/361 (44%), Gaps = 54/361 (14%)
Query: 20 HPENPGRLWLVLTAIRELGL--ENHVLEPSPIGEELIYRIHEREYV-------------- 63
HPE+ GR+ + + ++E GL + L E + +H +V
Sbjct: 203 HPEHAGRIQSIWSRLQERGLLSQCECLRGRKASLEELQSVHSERHVLLYGTNPLSRLKLD 262
Query: 64 ---------EKIRELSRRGGGYLDADTYVSP-RTWEAAILALGA-SRLATLSALRYGGMN 112
+++ + GG +D DT + + AA A G+ + LA A R
Sbjct: 263 NGKLAGLLAQRMFVMLPCGGVGVDTDTIWNELHSSNAARWAAGSVTDLAFKVASRELKNG 322
Query: 113 LALVRPPGHHAGRRGKALGAPTLGFCIFNNSAMAA--LTSKEETGKALVIDFDAHHGNGT 170
A+VRPPGHHA + +GFC FN+ A+A L + + K L++D+D HHGNGT
Sbjct: 323 FAVVRPPGHHADH------STAMGFCFFNSVAIACRQLQQQSKASKILIVDWDVHHGNGT 376
Query: 171 QEIFWDDADVVHIDLHERD---IYPGSGDVGEIGGINAKGSKINLP----MPHYSEDGDY 223
Q+ F+ D V++I LH D +PGSG V E+G + +G +N+ + D +Y
Sbjct: 377 QQTFYQDPSVLYISLHRHDDGNFFPGSGAVDEVGASSGEGFNVNVAWAGGLDPPMGDPEY 436
Query: 224 IYAWEEVVIPIVEEVKPKVVIVSAGFDGFKGD--GLTTLKLTEVFYSYAGATLRKY---P 278
+ A+ VV+PI E P +V+VSAGFD +G L ++ + Y L
Sbjct: 437 LAAFRIVVMPIAREFSPDLVLVSAGFDAAEGHPAPLGGYHVSAKCFGYMTQQLMNLAGGA 496
Query: 279 LAVILEGGYS----SGLKKGFPAFIRGYEEDKVRDHA---QPSYETLKLVEEVKDILSPW 331
+ + LEGG+ + A + G D + + +P+ ++ +E V + S +
Sbjct: 497 VVLALEGGHDLTAICDASEACVAALLGNRVDPLSEEGWKQKPNLNAIRSLEAVIRVHSKY 556
Query: 332 W 332
W
Sbjct: 557 W 557
>dbj|BAB15759.1| (AK024469) FLJ00062 protein [Homo sapiens]
Length = 484
Score = 122 bits (302), Expect = 8e-27
Identities = 101/361 (27%), Positives = 164/361 (44%), Gaps = 54/361 (14%)
Query: 20 HPENPGRLWLVLTAIRELGLENHV--LEPSPIGEELIYRIHEREYV-------------- 63
HPE+ GR+ + + ++E GL + L E + +H +V
Sbjct: 73 HPEHAGRIQSIWSRLQERGLRSQCECLRGRKASLEELQSVHSERHVLLYGTNPLSRLKLD 132
Query: 64 ---------EKIRELSRRGGGYLDADTYVSP-RTWEAAILALG-ASRLATLSALRYGGMN 112
+++ + GG +D DT + + AA A G + LA A R
Sbjct: 133 NGKLAGLLAQRMFVMLPCGGVGVDTDTIWNELHSSNAARWAAGRVTDLAFKVASRELKNG 192
Query: 113 LALVRPPGHHAGRRGKALGAPTLGFCIFNNSAMAA--LTSKEETGKALVIDFDAHHGNGT 170
A+VRPPGHHA + +GFC FN+ A+A L + + K L++D+D HHGNGT
Sbjct: 193 FAVVRPPGHHADH------STAMGFCFFNSVAIACRQLQQQSKASKILIVDWDVHHGNGT 246
Query: 171 QEIFWDDADVVHIDLHERD---IYPGSGDVGEIGGINAKGSKINLP----MPHYSEDGDY 223
Q+ F+ D V++I LH D +PGSG V E+G + +G +N+ + D +Y
Sbjct: 247 QQTFYQDPSVLYISLHRHDDGNFFPGSGAVDEVGAGSGEGFNVNVAWAGGLDPPMGDPEY 306
Query: 224 IYAWEEVVIPIVEEVKPKVVIVSAGFDGFKGD--GLTTLKLTEVFYSYAGATLRKY---P 278
+ A+ VV+PI E P +V+VSAGFD +G L ++ + Y L
Sbjct: 307 LAAFRIVVMPIAREFSPDLVLVSAGFDAAEGHPAPLGGYHVSAKCFGYMTQQLMNLAGGA 366
Query: 279 LAVILEGGYS----SGLKKGFPAFIRGYEEDKVRDHA---QPSYETLKLVEEVKDILSPW 331
+ + LEGG+ + A + G D + + +P+ ++ +E V + S +
Sbjct: 367 VVLALEGGHDLTAICDASEACVAALLGNRVDPLSEEGWKQKPNLNAIRSLEAVIRVHSKY 426
Query: 332 W 332
W
Sbjct: 427 W 427
>gi|7705399 histone deacetylase 7A [Homo sapiens]
>gi|7542540|gb|AAF63491.1|AF239243_1 (AF239243) histone
deacetylase 7 [Homo sapiens]
Length = 855
Score = 122 bits (302), Expect = 8e-27
Identities = 86/274 (31%), Positives = 135/274 (48%), Gaps = 45/274 (16%)
Query: 20 HPENPGRLWLVLTAIRELGLENHV--LEPSPIGEELIYRIHEREYV-------------- 63
HPE+ GR+ + + ++E GL + L E + +H +V
Sbjct: 501 HPEHAGRIQSIWSRLQERGLRSQCECLRGRKASLEELQSVHSERHVLLYGTNPLSRLKLD 560
Query: 64 ---------EKIRELSRRGGGYLDADTYVSP-RTWEAAILALGA-SRLATLSALRYGGMN 112
+++ E+ GG +D DT + + AA A G+ + LA A R
Sbjct: 561 NGKLAGLLAQRMFEMLPCGGVGVDTDTIWNELHSSNAARWAAGSVTDLAFKVASRELKNG 620
Query: 113 LALVRPPGHHAGRRGKALGAPTLGFCIFNNSAMAALTSKEET-----GKALVIDFDAHHG 167
A+VRPPGHHA + +GFC FN+ A+A ++++ K L++D+D HHG
Sbjct: 621 FAVVRPPGHHADH------STAMGFCFFNSVAIACRQLQQQSKASKASKILIVDWDVHHG 674
Query: 168 NGTQEIFWDDADVVHIDLHERD---IYPGSGDVGEIGGINAKGSKINLP----MPHYSED 220
NGTQ+ F+ D V++I LH D +PGSG V E+G + +G +N+ + D
Sbjct: 675 NGTQQTFYQDPSVLYISLHRHDDGNFFPGSGAVDEVGAGSGEGFNVNVAWAGGLDPPMGD 734
Query: 221 GDYIYAWEEVVIPIVEEVKPKVVIVSAGFDGFKG 254
+Y+ A+ VV+PI E P +V+VSAGFD +G
Sbjct: 735 PEYLAAFRIVVMPIAREFSPDLVLVSAGFDAAEG 768
>gb|AAF31418.1|AF207748_1 (AF207748) histone deacetylase 5 [Mus musculus]
Length = 1114
Score = 120 bits (299), Expect = 2e-26
Identities = 88/274 (32%), Positives = 137/274 (49%), Gaps = 48/274 (17%)
Query: 20 HPENPGRLWLVLTAIRELGL----------------------ENHVL--EPSPIGEELIY 55
HPE+ GR+ + + ++E GL E H L SP+ +
Sbjct: 696 HPEHAGRIQSIWSRLQETGLLGKCERIRGRKATLDEIQTVHSEYHTLLYGTSPLNRQ--- 752
Query: 56 RIHEREYV----EKIRELSRRGGGYLDADTYVSPRTWEAAI-LALGAS-RLATLSALRYG 109
++ ++ + +K+ + GG +D+DT + +A+ +A+G LA A
Sbjct: 753 KLDSKKLLGPISQKMYAMLPCGGIGVDSDTVWNEMHSSSAVRMAVGCLVELAFKVAAGEL 812
Query: 110 GMNLALVRPPGHHAGRRGKALGAPTLGFCIFNNSAMAA--LTSKEETGKALVIDFDAHHG 167
A++RPPGHHA + +GFC FN+ A+ A L K GK L++D+D HHG
Sbjct: 813 KNGFAIIRPPGHHAEE------STAMGFCFFNSVAITAKLLQQKLSVGKVLIVDWDIHHG 866
Query: 168 NGTQEIFWDDADVVHIDLHERD---IYPGSGDVGEIGGINAKGSKINLPMPHYSE----D 220
NGTQ+ F++D V++I LH D +PGSG E+GG G +N+ + D
Sbjct: 867 NGTQQAFYNDPSVLYISLHRYDNGNFFPGSGAPEEVGGGPGVGYNVNVAWTGGVDPPIGD 926
Query: 221 GDYIYAWEEVVIPIVEEVKPKVVIVSAGFDGFKG 254
+Y+ A+ VV+PI +E P VV+VSAGFD +G
Sbjct: 927 VEYLTAFRTVVMPIAQEFSPDVVLVSAGFDAVEG 960
>gi|6996924 histone deacetylase 5; histone deacetylase 4 [Mus musculus]
>gi|10720029|sp|Q9Z2V6|HDA5_MOUSE HISTONE DEACETYLASE 5
(HD5) (HISTONE DEACETYLASE MHDA1)
>gi|6978314|gb|AAD09834.2| (AF006602) histone
deacetylase mHDA1 [Mus musculus]
Length = 1113
Score = 120 bits (299), Expect = 2e-26
Identities = 88/274 (32%), Positives = 137/274 (49%), Gaps = 48/274 (17%)
Query: 20 HPENPGRLWLVLTAIRELGL----------------------ENHVL--EPSPIGEELIY 55
HPE+ GR+ + + ++E GL E H L SP+ +
Sbjct: 695 HPEHAGRIQSIWSRLQETGLLGKCERIRGRKATLDEIQTVHSEYHTLLYGTSPLNRQ--- 751
Query: 56 RIHEREYV----EKIRELSRRGGGYLDADTYVSPRTWEAAI-LALGAS-RLATLSALRYG 109
++ ++ + +K+ + GG +D+DT + +A+ +A+G LA A
Sbjct: 752 KLDSKKLLGPISQKMYAMLPCGGIGVDSDTVWNEMHSSSAVRMAVGCLVELAFKVAAGEL 811
Query: 110 GMNLALVRPPGHHAGRRGKALGAPTLGFCIFNNSAMAA--LTSKEETGKALVIDFDAHHG 167
A++RPPGHHA + +GFC FN+ A+ A L K GK L++D+D HHG
Sbjct: 812 KNGFAIIRPPGHHAEE------STAMGFCFFNSVAITAKLLQQKLSVGKVLIVDWDIHHG 865
Query: 168 NGTQEIFWDDADVVHIDLHERD---IYPGSGDVGEIGGINAKGSKINLPMPHYSE----D 220
NGTQ+ F++D V++I LH D +PGSG E+GG G +N+ + D
Sbjct: 866 NGTQQAFYNDPSVLYISLHRYDNGNFFPGSGAPEEVGGGPGVGYNVNVAWTGGVDPPIGD 925
Query: 221 GDYIYAWEEVVIPIVEEVKPKVVIVSAGFDGFKG 254
+Y+ A+ VV+PI +E P VV+VSAGFD +G
Sbjct: 926 VEYLTAFRTVVMPIAQEFSPDVVLVSAGFDAVEG 959
>gb|AAC18040.1| (AF039691) antigen NY-CO-9 [Homo sapiens]
Length = 897
Score = 120 bits (297), Expect = 3e-26
Identities = 107/365 (29%), Positives = 172/365 (46%), Gaps = 60/365 (16%)
Query: 20 HPENPGRLWLVLTAIRELGL----------------------ENHVL--EPSPIGEELIY 55
HPE+ GR+ + + ++E GL E H L SP+ +
Sbjct: 516 HPEHAGRIQSIWSRLQETGLLSKCERIRGRKATLDEIQTVHSEYHTLLYGTSPLNRQ--- 572
Query: 56 RIHEREYV----EKIRELSRRGGGYLDADTYVSPRTWEAAI-LALGAS-RLATLSALRYG 109
++ ++ + +K+ + GG +D+DT + +A+ +A+G LA A
Sbjct: 573 KLDSKKLLGPISQKMYAVLPCGGIGVDSDTVWNEMHSSSAVRMAVGCLLELAFKVAAGEL 632
Query: 110 GMNLALVRPPGHHAGRRGKALGAPTLGFCIFNNSAMAA--LTSKEETGKALVIDFDAHHG 167
A++RPPGHHA + +GFC FN+ A+ A L K GK L++D+D HHG
Sbjct: 633 KNGFAIIRPPGHHAEE------STAMGFCFFNSVAITAKLLQQKLNVGKVLIVDWDIHHG 686
Query: 168 NGTQEIFWDDADVVHIDLHERD---IYPGSGDVGEIGGINAKGSKINLPMPHYSE----D 220
NGTQ+ F++D V++I LH D +PGSG E+GG G +N+ + D
Sbjct: 687 NGTQQAFYNDPSVLYISLHRYDNGNFFPGSGAPEEVGGGPGVGYNVNVAWTGGVDPPIGD 746
Query: 221 GDYIYAWEEVVIPIVEEVKPKVVIVSAGFDGFKG--DGLTTLKLTEVFYSYAG---ATLR 275
+Y+ A+ VV+PI E P VV+VSAGFD +G L +T + + TL
Sbjct: 747 VEYLTAFRTVVMPIAHEFSPDVVLVSAGFDAVEGHLSPLGGYSVTARCFGHLTRQLMTLA 806
Query: 276 KYPLAVILEGGYS-SGLKKGFPAFIRGYEEDKVR--DHA----QPSYETLKLVEEVKDIL 328
+ + LEGG+ + + A + K++ D A +P+ + +E+V +I
Sbjct: 807 GGRVVLALEGGHDLTAICDASEACVSALLSVKLQPLDEAVLQQKPNINAVATLEKVIEIQ 866
Query: 329 SPWWS 333
S WS
Sbjct: 867 SKHWS 871
>gi|9624996 histone deacetylase 7 [Mus musculus]
>gi|6911184|gb|AAF31419.1|AF207749_1 (AF207749) histone
deacetylase 7 [Mus musculus]
Length = 938
Score = 120 bits (297), Expect = 3e-26
Identities = 89/271 (32%), Positives = 131/271 (47%), Gaps = 42/271 (15%)
Query: 20 HPENPGRLWLVLTAIRELGLEN--HVLEPSPIGEELIYRIHEREYV--EKIRELSRR--- 72
HPE+ GR+ + + ++E GL + L E + +H +V LSR
Sbjct: 528 HPEHAGRIQSIWSRLQERGLRSQCECLRGRKASLEELQSVHSERHVLLYGTNPLSRLKLD 587
Query: 73 ------------------GGGYLDADT-YVSPRTWEAAILALGA-SRLATLSALRYGGMN 112
GG +D DT + + AA A G+ + LA A R
Sbjct: 588 NGKLTGLLAQRTFVMLPCGGVGVDTDTIWNELHSSNAARWAAGSVTDLAFKVASRELKNG 647
Query: 113 LALVRPPGHHAGRRGKALGAPTLGFCIFNNSAMAA--LTSKEETGKALVIDFDAHHGNGT 170
A+VRPPGHHA + +GFC FN+ A+A L + K L++D+D HHGNGT
Sbjct: 648 FAVVRPPGHHADH------STAMGFCFFNSVAIACRQLQQHGKASKILIVDWDVHHGNGT 701
Query: 171 QEIFWDDADVVHIDLHERD---IYPGSGDVGEIGGINAKGSKINLP----MPHYSEDGDY 223
Q+ F+ D V++I LH D +PGSG V E+G + +G +N+ + D +Y
Sbjct: 702 QQTFYQDPSVLYISLHRHDDGNFFPGSGAVDEVGTASGEGFNVNVAWAGGLDPPMGDPEY 761
Query: 224 IYAWEEVVIPIVEEVKPKVVIVSAGFDGFKG 254
+ A+ VV+PI E P +V+VSAGFD +G
Sbjct: 762 LAAFRIVVMPIAREFAPDLVLVSAGFDAAEG 792
>dbj|BAA25526.1| (AB011172) KIAA0600 protein [Homo sapiens]
Length = 716
Score = 119 bits (296), Expect = 4e-26
Identities = 88/274 (32%), Positives = 136/274 (49%), Gaps = 48/274 (17%)
Query: 20 HPENPGRLWLVLTAIRELGL----------------------ENHVL--EPSPIGEELIY 55
HPE+ GR+ + + ++E GL E H L SP+ +
Sbjct: 298 HPEHAGRIQSIWSRLQETGLLSKCERIRGRKATLDEIQTVHSEYHTLLYGTSPLNRQ--- 354
Query: 56 RIHEREYV----EKIRELSRRGGGYLDADTYVSPRTWEAAI-LALGAS-RLATLSALRYG 109
++ ++ + +K+ + GG +D+DT + +A+ +A+G LA A
Sbjct: 355 KLDSKKLLGPISQKMYAVLPCGGIGVDSDTVWNEMHSSSAVRMAVGCLLELAFKVAAGEL 414
Query: 110 GMNLALVRPPGHHAGRRGKALGAPTLGFCIFNNSAMAA--LTSKEETGKALVIDFDAHHG 167
A++RPPGHHA + +GFC FN+ A+ A L K GK L++D+D HHG
Sbjct: 415 KNGFAIIRPPGHHAEE------STAMGFCFFNSVAITAKLLQQKLNVGKVLIVDWDIHHG 468
Query: 168 NGTQEIFWDDADVVHIDLHERD---IYPGSGDVGEIGGINAKGSKINLPMPHYSE----D 220
NGTQ+ F++D V++I LH D +PGSG E+GG G +N+ + D
Sbjct: 469 NGTQQAFYNDPSVLYISLHRYDNGNFFPGSGAPEEVGGGPGVGYNVNVAWTGGVDPPIGD 528
Query: 221 GDYIYAWEEVVIPIVEEVKPKVVIVSAGFDGFKG 254
+Y+ A+ VV+PI E P VV+VSAGFD +G
Sbjct: 529 VEYLTAFRTVVMPIAHEFSPDVVLVSAGFDAVEG 562
>gi|4885531 histone deacetylase 5; KIAA0600 protein [Homo sapiens]
>gi|11525894|ref|XP_008359.1| histone deacetylase 5
[Homo sapiens] >gi|10720027|sp|Q9UQL6|HDA5_HUMAN HISTONE
DEACETYLASE 5 (HD5) >gi|4754909|gb|AAD29047.1|AF132608_1
(AF132608) histone deacetylase 5 [Homo sapiens]
Length = 1122
Score = 119 bits (296), Expect = 4e-26
Identities = 88/274 (32%), Positives = 136/274 (49%), Gaps = 48/274 (17%)
Query: 20 HPENPGRLWLVLTAIRELGL----------------------ENHVL--EPSPIGEELIY 55
HPE+ GR+ + + ++E GL E H L SP+ +
Sbjct: 704 HPEHAGRIQSIWSRLQETGLLSKCERIRGRKATLDEIQTVHSEYHTLLYGTSPLNRQ--- 760
Query: 56 RIHEREYV----EKIRELSRRGGGYLDADTYVSPRTWEAAI-LALGAS-RLATLSALRYG 109
++ ++ + +K+ + GG +D+DT + +A+ +A+G LA A
Sbjct: 761 KLDSKKLLGPISQKMYAVLPCGGIGVDSDTVWNEMHSSSAVRMAVGCLLELAFKVAAGEL 820
Query: 110 GMNLALVRPPGHHAGRRGKALGAPTLGFCIFNNSAMAA--LTSKEETGKALVIDFDAHHG 167
A++RPPGHHA + +GFC FN+ A+ A L K GK L++D+D HHG
Sbjct: 821 KNGFAIIRPPGHHAEE------STAMGFCFFNSVAITAKLLQQKLNVGKVLIVDWDIHHG 874
Query: 168 NGTQEIFWDDADVVHIDLHERD---IYPGSGDVGEIGGINAKGSKINLPMPHYSE----D 220
NGTQ+ F++D V++I LH D +PGSG E+GG G +N+ + D
Sbjct: 875 NGTQQAFYNDPSVLYISLHRYDNGNFFPGSGAPEEVGGGPGVGYNVNVAWTGGVDPPIGD 934
Query: 221 GDYIYAWEEVVIPIVEEVKPKVVIVSAGFDGFKG 254
+Y+ A+ VV+PI E P VV+VSAGFD +G
Sbjct: 935 VEYLTAFRTVVMPIAHEFSPDVVLVSAGFDAVEG 968
>pir||F81178 histone deacetylase family protein NMB0605 [imported] - Neisseria
meningitidis (group B strain MD58)
>gi|7225835|gb|AAF41032.1| (AE002416) histone
deacetylase family protein [Neisseria meningitidis MC58]
Length = 369
Score = 119 bits (296), Expect = 4e-26
Identities = 86/288 (29%), Positives = 141/288 (48%), Gaps = 23/288 (7%)
Query: 14 HKPDNYHPENPGRLWLVLTAIRELGLENHV--LEPSPIGEELIYRIHEREYVEKIRELSR 71
H+P HP++P R+ + A+R G+ H+ +E I + + +H +Y+ ++
Sbjct: 35 HEPGANHPDSPDRILCIEQALRRAGIWQHLQTIEAEEISDTRLALVHSSKYLNRLESCLP 94
Query: 72 RGG--GYLDADTYVSPRTWEAAILALGASRLATLSAL-RYGGMNLALVRPPGHHAGRRGK 128
+ G LD DT +S + AA A G++ A + R RPPGHHAG GK
Sbjct: 95 QKGKISRLDNDTAISTGSLSAARFAAGSAVQAVDMVMNRKAWHAFCAARPPGHHAGS-GK 153
Query: 129 ALGAPTLGFCIFNNSAMAALTSKEE--TGKALVIDFDAHHGNGTQEIFWDDADVVHIDLH 186
A G FC+ NN A + + E + VIDFD H+G+GT EIF DD ++ +L
Sbjct: 154 AGG-----FCLLNNVAAGVMHAIAEYRLKRIAVIDFDVHYGDGTAEIFKDDPRILFFNLF 208
Query: 187 ERDIYPGSGDVGEIGGINAKGSKINLPMPHYSEDGDYIYAWEEVVIPIVEEVKPKVVIVS 246
E D++P E + G+ ++LP+P + + A +P + KP++V++S
Sbjct: 209 ETDLFP----FPENNDMPDGGNMVHLPLPPGTGSRTFREAVRRQWLPRLAAFKPELVLLS 264
Query: 247 AGFDGFKGDGLTTLKLTEVFYSYAGATLRKY------PLAVILEGGYS 288
AGFD + D L L E +++ + + + +LEGGY+
Sbjct: 265 AGFDAHRLDESGRLNLHEADFAWLTHKIIQTASGCPGKIISVLEGGYT 312
>pir||A81926 hypothetical protein NMA0810 [imported] - Neisseria meningitidis
(group A strain Z2491) >gi|7379529|emb|CAB84092.1|
(AL162754) hypothetical protein NMA0810 [Neisseria
meningitidis Z2491]
Length = 385
Score = 118 bits (293), Expect = 9e-26
Identities = 85/288 (29%), Positives = 141/288 (48%), Gaps = 23/288 (7%)
Query: 14 HKPDNYHPENPGRLWLVLTAIRELGLENHV--LEPSPIGEELIYRIHEREYVEKIRELSR 71
H+P HP++P R+ + A+R G+ H+ +E I + + +H +Y+ ++
Sbjct: 51 HEPGANHPDSPDRILCIEQALRRAGIWQHLQTIEAEEISDTRLALVHSSKYLNRLESCQP 110
Query: 72 RGGGY--LDADTYVSPRTWEAAILALGASRLATLSAL-RYGGMNLALVRPPGHHAGRRGK 128
+ G L+ DT +S + AA A G++ A + R RPPGHHAG GK
Sbjct: 111 QKGKIFRLNDDTAISTGSLSAARFAAGSAVQAVDMVMNRKAWHAFCAARPPGHHAGS-GK 169
Query: 129 ALGAPTLGFCIFNNSAMAALTSKEE--TGKALVIDFDAHHGNGTQEIFWDDADVVHIDLH 186
A G FC+ NN A + + E + VIDFD H+G+GT EIF DD ++ +L
Sbjct: 170 AGG-----FCLLNNVAAGVMHAIAEYRLKRIAVIDFDVHYGDGTAEIFKDDPRILFFNLF 224
Query: 187 ERDIYPGSGDVGEIGGINAKGSKINLPMPHYSEDGDYIYAWEEVVIPIVEEVKPKVVIVS 246
E D++P E + G+ ++LP+P + + A +P + KP++V++S
Sbjct: 225 ETDLFP----FPENNDMPDGGNMVHLPLPPGTGSRTFREAVRRQWLPRLAAFKPELVLLS 280
Query: 247 AGFDGFKGDGLTTLKLTEVFYSYAGATLRKY------PLAVILEGGYS 288
AGFD + D L L E +++ + + + +LEGGY+
Sbjct: 281 AGFDAHRLDESGRLNLHEADFAWLTHKIIQTASGCPGKIVSVLEGGYT 328
>gi|5174481 histone deacetylase 4; histone deacetylase A; KIAA0288 gene product
[Homo sapiens] >gi|11182425|sp|P56524|HDA4_HUMAN HISTONE
DEACETYLASE 4 (HD4) (KIAA0288) (HA6116)
>gi|4754907|gb|AAD29046.1|AF132607_1 (AF132607) histone
deacetylase 4 [Homo sapiens]
Length = 1084
Score = 116 bits (288), Expect = 4e-25
Identities = 104/367 (28%), Positives = 172/367 (46%), Gaps = 67/367 (18%)
Query: 20 HPENPGRLWLVLTAIRELGL----------------------ENHVL--EPSPIGEELIY 55
HPE+ GR+ + + ++E GL E H L +P+ +
Sbjct: 675 HPEHAGRIQSIWSRLQETGLRGKCECIRGRKATLEELQTVHSEAHTLLYGTNPLNRQ--- 731
Query: 56 RIHEREYVEKIRELSRR---GGGYLDADT-YVSPRTWEAAILALGAS-----RLATLSAL 106
++ ++ + + + R GG +D+DT + + AA LA+G ++AT L
Sbjct: 732 KLDSKKLLGSLASVFVRLPCGGVGVDSDTIWNEVHSAGAARLAVGCVVELVFKVAT-GEL 790
Query: 107 RYGGMNLALVRPPGHHAGRRGKALGAPTLGFCIFNNSAMAA--LTSKEETGKALVIDFDA 164
+ G A+VRPPGHHA + +GFC FN+ A+AA L + K L++D+D
Sbjct: 791 KNG---FAVVRPPGHHAEE------STPMGFCYFNSVAVAAKLLQQRLSVSKILIVDWDV 841
Query: 165 HHGNGTQEIFWDDADVVHIDLHERD---IYPGSGDVGEIGGINAKGSKINLPMPHYSE-- 219
HHGNGTQ+ F+ D V+++ LH D +PGSG E+G G +N+ +
Sbjct: 842 HHGNGTQQAFYSDPSVLYMSLHRYDDGNFFPGSGAPDEVGTGPGVGFNVNMAFTGGLDPP 901
Query: 220 --DGDYIYAWEEVVIPIVEEVKPKVVIVSAGFDGFKG--DGLTTLKLTEVFYSYAGATLR 275
D +Y+ A+ VV+PI E P VV+VS+GFD +G L L+ + Y L
Sbjct: 902 MGDAEYLAAFRTVVMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFGYLTKQLM 961
Query: 276 KYP---LAVILEGGYS----SGLKKGFPAFIRGYEEDKVRD---HAQPSYETLKLVEEVK 325
+ + LEGG+ + + + G E D + + +P+ ++ +E+V
Sbjct: 962 GLAGGRIVLALEGGHDLTAICDASEACVSALLGNELDPLPEKVLQQRPNANAVRSMEKVM 1021
Query: 326 DILSPWW 332
+I S +W
Sbjct: 1022 EIHSKYW 1028
>dbj|BAA22957.2| (AB006626) KIAA0288 protein [Homo sapiens]
Length = 1097
Score = 116 bits (288), Expect = 4e-25
Identities = 104/367 (28%), Positives = 172/367 (46%), Gaps = 67/367 (18%)
Query: 20 HPENPGRLWLVLTAIRELGL----------------------ENHVL--EPSPIGEELIY 55
HPE+ GR+ + + ++E GL E H L +P+ +
Sbjct: 688 HPEHAGRIQSIWSRLQETGLRGKCECIRGRKATLEELQTVHSEAHTLLYGTNPLNRQ--- 744
Query: 56 RIHEREYVEKIRELSRR---GGGYLDADT-YVSPRTWEAAILALGAS-----RLATLSAL 106
++ ++ + + + R GG +D+DT + + AA LA+G ++AT L
Sbjct: 745 KLDSKKLLGSLASVFVRLPCGGVGVDSDTIWNEVHSAGAARLAVGCVVELVFKVAT-GEL 803
Query: 107 RYGGMNLALVRPPGHHAGRRGKALGAPTLGFCIFNNSAMAA--LTSKEETGKALVIDFDA 164
+ G A+VRPPGHHA + +GFC FN+ A+AA L + K L++D+D
Sbjct: 804 KNG---FAVVRPPGHHAEE------STPMGFCYFNSVAVAAKLLQQRLSVSKILIVDWDV 854
Query: 165 HHGNGTQEIFWDDADVVHIDLHERD---IYPGSGDVGEIGGINAKGSKINLPMPHYSE-- 219
HHGNGTQ+ F+ D V+++ LH D +PGSG E+G G +N+ +
Sbjct: 855 HHGNGTQQAFYSDPSVLYMSLHRYDDGNFFPGSGAPDEVGTGPGVGFNVNMAFTGGLDPP 914
Query: 220 --DGDYIYAWEEVVIPIVEEVKPKVVIVSAGFDGFKG--DGLTTLKLTEVFYSYAGATLR 275
D +Y+ A+ VV+PI E P VV+VS+GFD +G L L+ + Y L
Sbjct: 915 MGDAEYLAAFRTVVMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFGYLTKQLM 974
Query: 276 KYP---LAVILEGGYS----SGLKKGFPAFIRGYEEDKVRD---HAQPSYETLKLVEEVK 325
+ + LEGG+ + + + G E D + + +P+ ++ +E+V
Sbjct: 975 GLAGGRIVLALEGGHDLTAICDASEACVSALLGNELDPLPEKVLQQRPNANAVRSMEKVM 1034
Query: 326 DILSPWW 332
+I S +W
Sbjct: 1035 EIHSKYW 1041
>gi|11428734 histone deacetylase A [Homo sapiens]
Length = 1143
Score = 116 bits (288), Expect = 4e-25
Identities = 104/367 (28%), Positives = 172/367 (46%), Gaps = 67/367 (18%)
Query: 20 HPENPGRLWLVLTAIRELGL----------------------ENHVL--EPSPIGEELIY 55
HPE+ GR+ + + ++E GL E H L +P+ +
Sbjct: 734 HPEHAGRIQSIWSRLQETGLRGKCECIRGRKATLEELQTVHSEAHTLLYGTNPLNRQ--- 790
Query: 56 RIHEREYVEKIRELSRR---GGGYLDADT-YVSPRTWEAAILALGAS-----RLATLSAL 106
++ ++ + + + R GG +D+DT + + AA LA+G ++AT L
Sbjct: 791 KLDSKKLLGSLASVFVRLPCGGVGVDSDTIWNEVHSAGAARLAVGCVVELVFKVAT-GEL 849
Query: 107 RYGGMNLALVRPPGHHAGRRGKALGAPTLGFCIFNNSAMAA--LTSKEETGKALVIDFDA 164
+ G A+VRPPGHHA + +GFC FN+ A+AA L + K L++D+D
Sbjct: 850 KNG---FAVVRPPGHHAEE------STPMGFCYFNSVAVAAKLLQQRLSVSKILIVDWDV 900
Query: 165 HHGNGTQEIFWDDADVVHIDLHERD---IYPGSGDVGEIGGINAKGSKINLPMPHYSE-- 219
HHGNGTQ+ F+ D V+++ LH D +PGSG E+G G +N+ +
Sbjct: 901 HHGNGTQQAFYSDPSVLYMSLHRYDDGNFFPGSGAPDEVGTGPGVGFNVNMAFTGGLDPP 960
Query: 220 --DGDYIYAWEEVVIPIVEEVKPKVVIVSAGFDGFKG--DGLTTLKLTEVFYSYAGATLR 275
D +Y+ A+ VV+PI E P VV+VS+GFD +G L L+ + Y L
Sbjct: 961 MGDAEYLAAFRTVVMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFGYLTKQLM 1020
Query: 276 KYP---LAVILEGGYS----SGLKKGFPAFIRGYEEDKVRD---HAQPSYETLKLVEEVK 325
+ + LEGG+ + + + G E D + + +P+ ++ +E+V
Sbjct: 1021 GLAGGRIVLALEGGHDLTAICDASEACVSALLGNELDPLPEKVLQQRPNANAVRSMEKVM 1080
Query: 326 DILSPWW 332
+I S +W
Sbjct: 1081 EIHSKYW 1087
>dbj|BAB06956.1| (AP001518) acetoin dehydrogenase [Bacillus halodurans]
Length = 389
Score = 115 bits (284), Expect = 1e-24
Identities = 80/270 (29%), Positives = 134/270 (49%), Gaps = 25/270 (9%)
Query: 7 YSRKFLLHKPDNYHPENPGRLWLVLTAIRELGL--ENHVLEPSPIGEELIYRIHEREYVE 64
YS L ++ + HP N RL L ++ + ++ ++ P E + IH++ +++
Sbjct: 8 YSENQLSYQFHSTHPFNHQRLRLTYDLLKSMDALDDSEIVAPRVATEAELRLIHDQAFID 67
Query: 65 KIRELSRRGGGYLD-----------ADTYVSPRTWEAAILALGASRLATLSALRYGGMNL 113
++ G G L DT + EAA L +G + L + + G
Sbjct: 68 AVKAA---GNGTLSDGVALNYGLGTEDTPIFKNMHEAAALLVGGT-LTAVDQVMEGHAEH 123
Query: 114 ALVRPPGHHAGRRGKALGAPTLGFCIFNNSAMAALTSKEETG-KALVIDFDAHHGNGTQE 172
A G H G RGKA G FC++N+S++A + + G + L ID DAHHG+G Q
Sbjct: 124 ACHLGGGLHHGFRGKASG-----FCVYNDSSIAIEYMRRKFGARVLYIDTDAHHGDGVQW 178
Query: 173 IFWDDADVVHIDLHE--RDIYPGSGDVGEIGGINAKGSKINLPMPHYSEDGDYIYAWEEV 230
F+++ DV + +HE R ++PG+G+ E G G IN+P+ ++ED +++A+E+
Sbjct: 179 AFYEEDDVCTLSIHETGRYLFPGTGNFNEKGQGEGYGYSINIPLDAFTEDDSFLFAYEQA 238
Query: 231 VIPIVEEVKPKVVIVSAGFDGFKGDGLTTL 260
V +V+ KP V++ G D D LT L
Sbjct: 239 VTNVVKFFKPDVILTQNGADAHFHDPLTHL 268
>pir||T27101 hypothetical protein Y51H1A.5 - Caenorhabditis elegans
>gi|5824816|emb|CAA21669.2| (AL032644) contains
similarity to Pfam domain: PF00850 (Histone deacetylase
family), Score=322.0, E-value=2.2e-93, N=1~cDNA EST
cm22d11 comes from this gene~cDNA EST yk125e11.5 comes
from this gene~cDNA EST yk638d2.3 comes from this
gene~cDNA EST yk534>
Length = 517
Score = 113 bits (281), Expect = 2e-24
Identities = 85/285 (29%), Positives = 136/285 (46%), Gaps = 21/285 (7%)
Query: 18 NYHPENPGRLWLVLTAIRELGL-ENHVLEPSP---IGEELIYRIHEREYVEKIRELSRRG 73
+YH E P RL +L + L + +E P E I +H + YV+ ++
Sbjct: 24 SYHIEVPRRLDAILERLNTTKLLTDPRIEHIPRREAEESEILAVHTKRYVDDVKSTETMT 83
Query: 74 GGYLDA------DTYVSPRTWEAAILALGASRLATLSALRYGGMNLALVRPPGHHAGRRG 127
++ D YV+ TW A LA GAS S + +A +RPPGHHA
Sbjct: 84 VEQQESFCTKYEDIYVNSATWHRAKLAAGASIDLMTSVMAAKRPGIAFIRPPGHHA---- 139
Query: 128 KALGAPTLGFCIFNNSAMAALTSKEETGKALVIDFDAHHGNGTQEIF--WDDADVVHIDL 185
+ GFCIFNN A+AA + + K L++D+D H GNGTQE + +V I +
Sbjct: 140 --MPDEGCGFCIFNNVAIAAKAAIQNGQKVLIVDYDVHAGNGTQECVEQMGEGNVQLISI 197
Query: 186 HERDIYPGSGDVGEIGGINAKGSKINLPMPHYS-EDGDYIYAWEEVVIPIVEEVKPKVVI 244
H + ++ + G + + INLP+ D DY + +++P + +P +++
Sbjct: 198 HRYENGHFWPNMPQTGIYHNYKNTINLPLNTIGLTDADYHALFTHIILPTIHAFQPDLLL 257
Query: 245 VSAGFDGFKGDGLTTLKLTEVFYSYAGATL--RKYPLAVILEGGY 287
VS+GFD GD ++++T ++ L P+A +LEGGY
Sbjct: 258 VSSGFDASIGDPEGSMQVTPAGFATMIRMLIDTGIPVAALLEGGY 302
>gb|AAK41373.1| Acetoin utilization protein [Sulfolobus solfataricus]
Length = 348
Score = 112 bits (277), Expect = 7e-24
Identities = 86/302 (28%), Positives = 145/302 (47%), Gaps = 23/302 (7%)
Query: 44 LEPSPIGEELIYRIHEREYVEKIRELSRRGG-GYLD-ADTYVSPRTWEAAILALGASRLA 101
+ P +E + +H R+Y+ + E S+ G+LD DT P +E +L LG+S
Sbjct: 54 IRPEYATKEDLMVVHTRDYIGLLEESSKIPYIGFLDQGDTVHYPGMFEDILLVLGSS--- 110
Query: 102 TLSALRYGGMNLALVRPPG--HHAGRRGKALGAPTLGFCIFNNSAMAALTSKEETGKALV 159
+A++Y + P G HHA + +GFC N+ A+ AL E+ + +
Sbjct: 111 -FTAIKYSKFLDYVYIPLGGFHHA------MPNRAVGFCPINDVAITALKLLEKGERVAI 163
Query: 160 IDFDAHHGNGTQEIFWDDADV-VHIDLHERDIYPGSGDVGEIGGINAKGSKINLPMPHYS 218
+D DAHHGNG Q I +D + ++I ++ + +PG+G + EIG +G IN+P+P S
Sbjct: 164 VDVDAHHGNGLQFILYDKPILKINIYAYDGNFFPGTGKIDEIGEGKGRGYNINIPLPLGS 223
Query: 219 EDGDYIYAWEEVVIPIVEEVKPKVVIVSAGFDGFKGDGLTTLKLTEVFYSYAGATLRKYP 278
D + + E ++ ++E P V+V AG DG K D L +L LT Y+ G +R+
Sbjct: 224 TDDIFEKSLE--ILDLLELYNPSYVLVVAGVDGHKNDQLKSLDLTTNSYNLLGLRIRRIK 281
Query: 279 LAVILE------GGYSSGLKKGFPAFIRGYEEDKVRDHAQPSYETLKLVEEVKDILSPWW 332
+ GGY +F+ G + S E + + ++ I+S +
Sbjct: 282 KTINSSIIAYGGGGYGPMSSLSMVSFLEGLLGRRTSYEPLTSSEDIGKIRRIEKIISRFK 341
Query: 333 SL 334
+L
Sbjct: 342 TL 343
>sp|Q48935|APHA_MYCRA ACETYLPOLYAMINE AMINOHYDROLASE >gi|11360471|pir||T48858
acetylpolyamine aminohydrolase [validated] - Mycoplana
ramosa >gi|520593|dbj|BAA01256.1| (D10463)
acetylpolyamine aminohydolase [Mycoplana ramosa]
Length = 341
Score = 107 bits (265), Expect = 2e-22
Identities = 90/308 (29%), Positives = 142/308 (45%), Gaps = 54/308 (17%)
Query: 22 ENPGRLWLVLTAIRELGLENHVLEPSPIGEELIYRIHEREYVEKIR-------------- 67
E P R +L A++E G ++ V+ P+ G E + ++H+ Y+ +
Sbjct: 28 EAPFRAEWILAAVKEAGFDD-VVAPARHGLETVLKVHDAGYLNFLETAWDRWKAAGYKGE 86
Query: 68 -----------------ELSRRGGGYLDA-DTYVSPRTWEAAILALGASRLATLSALRYG 109
++ + G Y +A +T +SP TWEAA+ ++ AS + + G
Sbjct: 87 AIATSFPVRRTSPRIPTDIEGQIGYYCNAAETAISPGTWEAALSSM-ASAIDGADLIAAG 145
Query: 110 GMN-LALVRPPGHHAGRRGKALGAPTLGFCIFNNSAMAALTSKEETGKAL-VIDFDAHHG 167
+L RPPGHHAG G G+C NN+A+AA ++ K + ++D D HHG
Sbjct: 146 HKAAFSLCRPPGHHAGI--DMFG----GYCFINNAAVAAQRLLDKGAKKIAILDVDFHHG 199
Query: 168 NGTQEIFWDDADVVHIDLH--ERDIYPG-SGDVGEIGGINAKGSKINLPMPHYSEDGDYI 224
NGTQ+IF++ DV LH + +P G E G G+ N PM G
Sbjct: 200 NGTQDIFYERGDVFFASLHGDPAEAFPHFLGYAEETGKGAGAGTTANYPMGR----GTPY 255
Query: 225 YAWEEVVIPIVEEVK---PKVVIVSAGFDGFKGDGLTTLKLTEVFYSYAGATLRK--YPL 279
W E + ++ + + ++VS G D F+ D ++ KLT Y G T+ PL
Sbjct: 256 SVWGEALTDSLKRIAAFGAEAIVVSLGVDTFEQDPISFFKLTSPDYITMGRTIAASGVPL 315
Query: 280 AVILEGGY 287
V++EGGY
Sbjct: 316 LVVMEGGY 323
>sp|P39067|ACUC_BACSU ACETOIN UTILIZATION ACUC PROTEIN >gi|628994|pir||S39643 acetate /
acetoin utilization protein acuC - Bacillus subtilis
>gi|348050|gb|AAA68284.1| (L17309) acetoin utilization
protein [Bacillus subtilis] >gi|2293316|gb|AAC00394.1|
(AF008220) acetoin catabolism protein AcuC [Bacillus
subtilis] >gi|2635455|emb|CAB14949.1| (Z99119) acetoin
dehydrogenase [Bacillus subtilis]
Length = 387
Score = 107 bits (265), Expect = 2e-22
Identities = 80/277 (28%), Positives = 128/277 (45%), Gaps = 25/277 (9%)
Query: 7 YSRKFLLHKPDNYHPENPGRLWLVLTAIRELGL--ENHVLEPSPIGEELIYRIHEREYVE 64
YS + + HP N R+ L ++ + + ++ P EE + +H +Y++
Sbjct: 8 YSPSYQTYMFHQEHPFNQQRVLLTYDLLKTINAFDDGDIVTPRLASEEELSLVHTDDYIQ 67
Query: 65 KIRELSRRGGGYLDA-----------DTYVSPRTWEAAILALGASRLATLSALRYGGMNL 113
++ G G L A DT V EAA L +G + A + ++
Sbjct: 68 AVK---LAGAGKLPAEEGESYGLGTEDTPVFAGMHEAASLLVGGTLTAADWVMSGQALHA 124
Query: 114 ALVRPPGHHAGRRGKALGAPTLGFCIFNNSAMAA-LTSKEETGKALVIDFDAHHGNGTQE 172
A + HH G RG+A G FCI+N+SA+A K+ + + L ID DAHHG+G Q
Sbjct: 125 ANLGGGLHH-GFRGRASG-----FCIYNDSAVAIQYIQKKYSARVLYIDTDAHHGDGVQF 178
Query: 173 IFWDDADVVHIDLHE--RDIYPGSGDVGEIGGINAKGSKINLPMPHYSEDGDYIYAWEEV 230
F+D+ DV + +HE R ++PG+G + E G G N+P+ ++ED ++ A+
Sbjct: 179 TFYDNPDVCTLSIHETGRYLFPGTGQIQEKGSGKGYGYSFNIPLDAFTEDDSFLEAYRTA 238
Query: 231 VIPIVEEVKPKVVIVSAGFDGFKGDGLTTLKLTEVFY 267
+ +P V+I G D D LT L T Y
Sbjct: 239 ASEVAAYFEPDVIISQNGADAHYYDPLTHLSATINIY 275
>gb|AAF48245.1| (AE003492) CG1770 gene product [Drosophila melanogaster]
Length = 1235
Score = 106 bits (262), Expect = 4e-22
Identities = 82/268 (30%), Positives = 120/268 (44%), Gaps = 39/268 (14%)
Query: 20 HPENPGRLWLVLTAIRELGLENHV--LEPSPIGEELIYRIHEREYVEKIR----ELSRR- 72
HPE+ GRL V + E L L +E + +H + +LSR
Sbjct: 843 HPEHSGRLQSVWARLNETDLVKRCDRLRARKATQEELQTVHTEAHAMLFGSNQCQLSRPK 902
Query: 73 --------------GGGYLDADT-YVSPRTWEAAILALGASRLATLSALRYGGMN-LALV 116
GG +D DT + T AA +A G L + N A+V
Sbjct: 903 LENTLSASFVRLSCGGLGVDLDTTWNEHHTATAARMAAGCVIDLALKTAKGDLRNGFAVV 962
Query: 117 RPPGHHAGRRGKALGAPTLGFCIFNNSAMAALTSKE---ETGKALVIDFDAHHGNGTQEI 173
RPPGHHA +GFC FN+ A+AA ++ E + L++D+D HHGNGTQ+
Sbjct: 963 RPPGHHAEAN------LAMGFCFFNSIAIAAKLLRQRMPEVRRILIVDWDVHHGNGTQQA 1016
Query: 174 FWDDADVVHIDLHERD---IYPGSGDVGEIGGINAKGSKINLPMPHYSE----DGDYIYA 226
F+ D++++ +H D +PG+G E G G +N+ D +YI A
Sbjct: 1017 FYQSPDILYLSIHRHDDGNFFPGTGGPTECGSGAGLGFNVNISWSGALNPPLGDAEYIAA 1076
Query: 227 WEEVVIPIVEEVKPKVVIVSAGFDGFKG 254
+ VV+PI P +V+VS+GFD G
Sbjct: 1077 FRTVVMPIARSFNPDIVLVSSGFDAATG 1104
>gb|AAG28403.1|AF193434_1 (AF193434) putative histone deacetylase [Cryptosporidium parvum]
Length = 437
Score = 104 bits (257), Expect = 2e-21
Identities = 73/283 (25%), Positives = 132/283 (45%), Gaps = 20/283 (7%)
Query: 20 HPENPGRLWLVLTAIRELGL--ENHVLEPSPIGEELIYRIHEREYVEKIRELSRRG-GGY 76
HP P R+ + + + GL + V+ P+P E + R H +YV+ +R ++ Y
Sbjct: 24 HPMKPHRVRMTHDLVSQYGLLEKVDVMVPTPGTVESLTRFHSNDYVDFLRSVNTDNMHDY 83
Query: 77 LD--------ADTYVSPRTWEAAILALGASRLATLSALRYGGMNLALVRPPGHHAGRRGK 128
D D V WE L+ G S L ++ G A+ G H G++ +
Sbjct: 84 SDHLARFNVGEDCPVFDGLWEFCQLSAGGS-LGGAQSVNELGYQYAINWAGGLHHGKKHE 142
Query: 129 ALGAPTLGFCIFNNSAMAALTSKEETGKALVIDFDAHHGNGTQEIFWDDADVVHIDLHER 188
A G FC N+ + AL + + +D D HHG+G +E F+ + + H+
Sbjct: 143 ASG-----FCYVNDCVLGALEFLKYQHRVCYVDIDIHHGDGVEEAFYTSPRCMCVSFHKY 197
Query: 189 -DIYPGSGDVGEIGGINAKGSKINLPMPHYSEDGDYIYAWEEVVIPIVEEVKPKVVIVSA 247
D +PG+G + ++G G +N+P+ +D +I + +V+ ++E +P +++
Sbjct: 198 GDYFPGTGALNDVGVEEGLGYSVNVPLKDGVDDATFIDLFTKVMTLVMENYRPGAIVLQC 257
Query: 248 GFDGFKGDGLTTLKLTEVFYSYAGATLRKY--PLAVILEGGYS 288
G D GD L L+ + +A + L+K+ PL ++ GGY+
Sbjct: 258 GADSLSGDRLGCFNLSLKGHGHAVSFLKKFNVPLLILGGGGYT 300
>dbj|BAA91474.1| (AK001032) unnamed protein product [Homo sapiens]
Length = 276
Score = 102 bits (252), Expect = 6e-21
Identities = 52/129 (40%), Positives = 78/129 (60%), Gaps = 9/129 (6%)
Query: 135 LGFCIFNNSAMAA--LTSKEETGKALVIDFDAHHGNGTQEIFWDDADVVHIDLHERD--- 189
+GFC FN+ A+A L + + K L++D+D HHGNGTQ+ F+ D V++I LH D
Sbjct: 1 MGFCFFNSVAIACRQLQQQSKASKILIVDWDVHHGNGTQQTFYQDPSVLYISLHRHDDGN 60
Query: 190 IYPGSGDVGEIGGINAKGSKINLP----MPHYSEDGDYIYAWEEVVIPIVEEVKPKVVIV 245
+PGSG V E+G + +G +N+ + D +Y+ A+ VV+PI E P +V+V
Sbjct: 61 FFPGSGAVDEVGAGSGEGFNVNVAWAGGLDPPMGDPEYLAAFRIVVMPIAREFSPDLVLV 120
Query: 246 SAGFDGFKG 254
SAGFD +G
Sbjct: 121 SAGFDAAEG 129
>pir||B83605 probable acetylpolyamine aminohydrolase PA0321 [imported] -
Pseudomonas aeruginosa (strain PAO1)
>gi|9946168|gb|AAG03710.1|AE004470_4 (AE004470) probable
acetylpolyamine aminohydrolase [Pseudomonas aeruginosa]
Length = 344
Score = 102 bits (251), Expect = 8e-21
Identities = 90/306 (29%), Positives = 133/306 (43%), Gaps = 48/306 (15%)
Query: 22 ENPGRLWLVLTAIRELGLENHVLEPSPIGEELIYRIHEREYVEKIREL------------ 69
E P R +VL ++ +GL V P G E I R+H +V ++
Sbjct: 28 EKPSRADMVLDRVKAVGL-GEVRAPRDFGLEPIRRVHSEGFVRFLQNAWQDWLATGRSHD 86
Query: 70 --------------------SRRGGGYLDADTYVSPRTWEAAILALGASRLATLSALRYG 109
R G DA ++ TW+A + + L+ S L G
Sbjct: 87 MLPIAWPTRRLRQTEPDNIDGRLGYYSFDAGAPITAGTWQAITSSANVA-LSGQSELANG 145
Query: 110 GMNL-ALVRPPGHHAGRRGKALGAPTLGFCIFNNSAMAALTSKEE-TGKALVIDFDAHHG 167
++ +L RPPGHHA +G G+C FNN+A+AA + G+ ++D D HHG
Sbjct: 146 ARSVFSLCRPPGHHAA--ADYMG----GYCFFNNAAIAAQAFLDRGAGRVAILDVDYHHG 199
Query: 168 NGTQEIFWDDADVVHIDLH--ERDIYP-GSGDVGEIGGINAKGSKINLPMPHYSEDGDYI 224
NGTQ+IF+D ADV+ +H R YP G E G G N P+ S+ +
Sbjct: 200 NGTQDIFYDRADVLFTSIHGDPRFEYPYFLGYADEKGNGVGTGYNFNYPLAAGSDWATWS 259
Query: 225 YAWEEVVIPIVEEVKPKVVIVSAGFDGFKGDGLTTLKLTEVFYSYAGATLRKYPLAV--I 282
A + I ++ +IVS G D FK D ++ +L Y G + K LA +
Sbjct: 260 QAL-QAAIRQIQAYAADALIVSLGVDTFKEDPISQFRLDSPDYLRMGEAIGKLGLATLFV 318
Query: 283 LEGGYS 288
+EGGY+
Sbjct: 319 MEGGYA 324
>sp|Q56195|ACUC_STAXY ACETOIN UTILIZATION ACUC PROTEIN >gi|1177686|emb|CAA64714.1|
(X95439) acuC [Staphylococcus xylosus]
Length = 385
Score = 101 bits (249), Expect = 1e-20
Identities = 74/270 (27%), Positives = 128/270 (47%), Gaps = 19/270 (7%)
Query: 7 YSRKFLLHKPDNYHPENPGRLWLVLTAIRELGL--ENHVLEPSPIGEELIYRIHEREYVE 64
Y+ + L ++ N HP N RL L + ELG ++H++ P ++ + IH +Y++
Sbjct: 12 YANELLQYRFSNKHPFNQMRLKLTTELLMELGQLKQHHIISPRIATDDELSLIHAYDYIQ 71
Query: 65 KIRELSRRGGGYLDADTYV--SPRTWEAAILALGASRLATLSALRYGGMNLALVRPPG-- 120
IR S +A Y T + ++ ++R+ G +NLA G
Sbjct: 72 AIRHASHGILSENEAKKYGLDGEDTLQFRMMHKHSARIVG------GALNLADQIMSGTL 125
Query: 121 ----HHAGRRGKALGAPTLGFCIFNNSAMA-ALTSKEETGKALVIDFDAHHGNGTQEIFW 175
H G +L GFCI+N+ A+ + ++ + L ID DAHHG+GTQ F+
Sbjct: 126 TNGCHLGGGLHHSLPGRANGFCIYNDVAITISYLMQKYNQRVLCIDTDAHHGDGTQWSFY 185
Query: 176 DDADVVHIDLHE--RDIYPGSGDVGEIGGINAKGSKINLPMPHYSEDGDYIYAWEEVVIP 233
+ + +HE + ++PGSG E G G +N+P+ Y+ED ++ +++ + P
Sbjct: 186 TNDQALIYSIHETGKFLFPGSGHYTERGAEKGFGYTVNIPLEPYTEDQSFLDVFKQTIEP 245
Query: 234 IVEEVKPKVVIVSAGFDGFKGDGLTTLKLT 263
+V KP +++ G D D LT + T
Sbjct: 246 VVASFKPDIIVSVHGVDVHYLDPLTHMSCT 275
>pir||H83469 acetylpolyamine aminohydrolase PA1409 [imported] - Pseudomonas
aeruginosa (strain PAO1)
>gi|9947356|gb|AAG04798.1|AE004570_6 (AE004570)
acetylpolyamine aminohydrolase [Pseudomonas aeruginosa]
Length = 346
Score = 97.9 bits (240), Expect = 2e-19
Identities = 88/308 (28%), Positives = 134/308 (42%), Gaps = 50/308 (16%)
Query: 22 ENPGRLWLVLTAIRELGLENHVLEPSPIGEELIYRIHEREYVEKI--------------- 66
E P R VL ++ L V+ P G E + R+H+ Y++ +
Sbjct: 28 EMPSRADTVLARVKSQNL-GEVIAPKDFGREPLLRLHDAAYLDFLQGAWARWTAEGHSGD 86
Query: 67 --------RELSRRGG---------GYLDADTY--VSPRTWEAAILALGASRLATLSALR 107
R L R G GY DT ++ TW+A I + L +R
Sbjct: 87 LVSTTFPGRRLRRDGPIPTALMGELGYYSFDTEAPITAGTWQA-IYSSAQVALTAQEHMR 145
Query: 108 YGGMN-LALVRPPGHHAGRRGKALGAPTLGFCIFNNSAMAALTSKEETGKAL-VIDFDAH 165
G + AL RPPGHHAG G +G G+C NN+A+A ++ + + ++D D H
Sbjct: 146 QGARSAFALCRPPGHHAG--GDFMG----GYCFLNNAAIATQAFLDQGARRVAILDVDYH 199
Query: 166 HGNGTQEIFWDDADVVHIDLH--ERDIYP-GSGDVGEIGGINAKGSKINLPMPHYSEDGD 222
HGNGTQ+IF+ DV+ +H R YP G E G +G N P+ H S
Sbjct: 200 HGNGTQDIFYRRDDVLFASIHGDPRVEYPYFLGYADERGEGAGEGCNHNYPLAHGSGWDL 259
Query: 223 YIYAWEEVVIPIVEEVKPKVVIVSAGFDGFKGDGLTTLKLTEVFYSYAGATLRK--YPLA 280
+ A ++ + I P +++S G D +K D ++ +L Y G + + P
Sbjct: 260 WSAALDDACVRIA-GYAPDALVISLGVDTYKEDPISQFRLDSPDYLRMGERIARLGLPTL 318
Query: 281 VILEGGYS 288
I+EGGY+
Sbjct: 319 FIMEGGYA 326
>sp|O22446|HDAC_ARATH HISTONE DEACETYLASE (HD) >gi|2318131|gb|AAB66486.1| (AF014824)
histone deacetylase [Arabidopsis thaliana]
>gi|11066139|gb|AAG28474.1|AF195547_1 (AF195547)
putative histone deacetylase [Arabidopsis thaliana]
Length = 501
Score = 96.0 bits (235), Expect = 6e-19
Identities = 83/342 (24%), Positives = 146/342 (42%), Gaps = 52/342 (15%)
Query: 2 IGEIYYSRKFLLHKPDNYHPENPGRLWLVLTAIRELGLENH--VLEPSPIGEELIYRIHE 59
+G YY + HP P R+ + + GL H VL+P P E + R H
Sbjct: 27 VGNYYYGQG---------HPMKPHRIRMTHALLAHYGLLQHMQVLKPFPARERDLCRFHA 77
Query: 60 REYV------------EKIRELSRRGGGYLDADTYVSPRTWEAAILALGASRLATLSALR 107
+YV ++IR+L R G D V + G S ++ L
Sbjct: 78 DDYVSFLRSITPETQQDQIRQLKRFNVG---EDCPVFDGLYSFCQTYAGGSVGGSVK-LN 133
Query: 108 YGGMNLALVRPPGHHAGRRGKALGAPTLGFCIFNNSAMAALTSKEETGKALVIDFDAHHG 167
+G ++A+ G H ++ +A G FC N+ +A L ++ + L +D D HHG
Sbjct: 134 HGLCDIAINWAGGLHHAKKCEASG-----FCYVNDIVLAILELLKQHERVLYVDIDIHHG 188
Query: 168 NGTQEIFWDDADVVHIDLHE-RDIYPGSGDVGEIGGINAKGSKINLPMPHYSEDGDYIYA 226
+G +E F+ V+ + H+ D +PG+G + +IG + K +N+P+ +D Y
Sbjct: 189 DGVEEAFYATDRVMTVSFHKFGDYFPGTGHIQDIGYGSGKYYSLNVPLDDGIDDESYHLL 248
Query: 227 WEEVVIPIVEEVKPKVVIVSAGFDGFKGDGLTTLKLTEVFYSYAGATLRKYPLAVILEGG 286
++ ++ ++E +P V++ G D GD L L+ ++ +R + + ++L GG
Sbjct: 249 FKPIMGKVMEIFRPGAVVLQCGADSLSGDRLGCFNLSIKGHAECVKFMRSFNVPLLLLGG 308
Query: 287 -------------YSSGLKKGFPAFIRGYEEDKVRDHAQPSY 315
Y +G+ G EDK+ +H Y
Sbjct: 309 GGYTIRNVARCWCYETGVALGVEV------EDKMPEHEYYEY 344
>pir||T36278 hypothetical protein SCE68.28c - Streptomyces coelicolor
>gi|5123675|emb|CAB45364.1| (AL079345) hypothetical
protein [Streptomyces coelicolor A3(2)]
Length = 367
Score = 96.0 bits (235), Expect = 6e-19
Identities = 69/252 (27%), Positives = 117/252 (46%), Gaps = 17/252 (6%)
Query: 23 NPGRLWLVLTAIRELGLENHV--LEPSPIGEELIYRIHEREYVEKIRELS---RRGGGYL 77
+P RL L + + LGL+ V + P GE + +H +Y++ +R S R G
Sbjct: 2 DPVRLALTRSLVGALGLDREVEVVAARPAGESTLRLVHREDYIDAVRAASADPRSADGSY 61
Query: 78 DADTYVSPR---TWEAAILALGASRLATLSALRYGGMNLALVRPPGHHAGRRGKALGAPT 134
T P E + L G S A + R ++ HHA +
Sbjct: 62 GLGTVDDPAFAGMHEVSALIAGQSVGAAEAVWRGDALHAVNFAGGLHHA------MPGAA 115
Query: 135 LGFCIFNNSAMAALTSKEETGKALV-IDFDAHHGNGTQEIFWDDADVVHIDLHERD--IY 191
GFC++N++A+A E + + +D D HHG+G Q FW+D V+ + LHE ++
Sbjct: 116 SGFCVYNDAALAIARLLELGAERVAYVDVDVHHGDGVQAAFWEDPRVLTVSLHEHPATLF 175
Query: 192 PGSGDVGEIGGINAKGSKINLPMPHYSEDGDYIYAWEEVVIPIVEEVKPKVVIVSAGFDG 251
P +G E G A+GS +N+ +P + D ++ A+ VV ++ + +P+V++ G D
Sbjct: 176 PQTGWPEETGADCAEGSAVNVALPAGTGDAGWLRAFHAVVPEVLADFRPQVLVTQHGADT 235
Query: 252 FKGDGLTTLKLT 263
D L L ++
Sbjct: 236 HFEDPLAHLAVS 247
>sp|P56521|HDAC_MAIZE PROBABLE HISTONE DEACETYLASE (RPD3 HOMOLOG) >gi|7444256|pir||T01413
probable histone deacetylase (EC 3.5.1.-) rpd3 - maize
>gi|2665840|gb|AAC50038.1| (AF035815) putative histone
deacetylase RPD3 [Zea mays]
Length = 513
Score = 94.8 bits (232), Expect = 1e-18
Identities = 76/305 (24%), Positives = 135/305 (43%), Gaps = 44/305 (14%)
Query: 2 IGEIYYSRKFLLHKPDNYHPENPGRLWLVLTAIRELGLENH--VLEPSPIGEELIYRIHE 59
+G YY + HP P R+ + + + GL N V P+P E + R H
Sbjct: 33 VGNYYYGQG---------HPMKPHRIRMTHSLLARYGLLNQMQVYRPNPARERELCRFHA 83
Query: 60 REYV------------EKIRELSRRGGG----YLDADTYVSPRTWEAAILALGASRLATL 103
EY+ ++IR L R G LD Y +T+ A +
Sbjct: 84 EEYINFLRSVTPETQQDQIRLLKRFNVGEECPVLDG-LYSFCQTYAGASVG--------- 133
Query: 104 SALRYG-GMNLALVRPPGHHAGRRGKALGAPTLGFCIFNNSAMAALTSKEETGKALVIDF 162
A+++ G ++A+ G H ++ +A G FC N+ +A L + + L +D
Sbjct: 134 GAVKFNHGHDIAINWSGGLHHAKKCEASG-----FCYVNDIVLAILELLKHHERVLYVDI 188
Query: 163 DAHHGNGTQEIFWDDADVVHIDLHE-RDIYPGSGDVGEIGGINAKGSKINLPMPHYSEDG 221
D HHG+G +E F+ V+ + H+ D +PG+GD+ +IG K +N+P+ +D
Sbjct: 189 DIHHGDGVEEAFYTTDRVMTVSFHKFGDYFPGTGDIRDIGHSKGKYYSLNVPLDDGIDDE 248
Query: 222 DYIYAWEEVVIPIVEEVKPKVVIVSAGFDGFKGDGLTTLKLTEVFYSYAGATLRKYPLAV 281
Y ++ ++ ++E +P V++ G D GD L L+ ++ +R + + +
Sbjct: 249 SYQSLFKPIMGKVMEVFRPGAVVLQCGADSLSGDRLGCFNLSIKGHAECVRYMRSFNVPL 308
Query: 282 ILEGG 286
+L GG
Sbjct: 309 LLLGG 313
>pir||T05640 histone deacetylase (EC 3.5.1.-) F20D10.250 - Arabidopsis thaliana
>gi|4467119|emb|CAB37553.1| (AL035538) Histone
deacetylase [Arabidopsis thaliana]
>gi|7270797|emb|CAB80478.1| (AL161593) Histone
deacetylase [Arabidopsis thaliana]
Length = 501
Score = 94.8 bits (232), Expect = 1e-18
Identities = 82/342 (23%), Positives = 146/342 (41%), Gaps = 52/342 (15%)
Query: 2 IGEIYYSRKFLLHKPDNYHPENPGRLWLVLTAIRELGLENH--VLEPSPIGEELIYRIHE 59
+G YY + HP P R+ + + GL H VL+P P + + R H
Sbjct: 27 VGNYYYGQG---------HPMKPHRIRMTHALLAHYGLLQHMQVLKPFPARDRDLCRFHA 77
Query: 60 REYV------------EKIRELSRRGGGYLDADTYVSPRTWEAAILALGASRLATLSALR 107
+YV ++IR+L R G D V + G S ++ L
Sbjct: 78 DDYVSFLRSITPETQQDQIRQLKRFNVG---EDCPVFDGLYSFCQTYAGGSVGGSVK-LN 133
Query: 108 YGGMNLALVRPPGHHAGRRGKALGAPTLGFCIFNNSAMAALTSKEETGKALVIDFDAHHG 167
+G ++A+ G H ++ +A G FC N+ +A L ++ + L +D D HHG
Sbjct: 134 HGLCDIAINWAGGLHHAKKCEASG-----FCYVNDIVLAILELLKQHERVLYVDIDIHHG 188
Query: 168 NGTQEIFWDDADVVHIDLHE-RDIYPGSGDVGEIGGINAKGSKINLPMPHYSEDGDYIYA 226
+G +E F+ V+ + H+ D +PG+G + +IG + K +N+P+ +D Y
Sbjct: 189 DGVEEAFYATDRVMTVSFHKFGDYFPGTGHIQDIGYGSGKYYSLNVPLDDGIDDESYHLL 248
Query: 227 WEEVVIPIVEEVKPKVVIVSAGFDGFKGDGLTTLKLTEVFYSYAGATLRKYPLAVILEGG 286
++ ++ ++E +P V++ G D GD L L+ ++ +R + + ++L GG
Sbjct: 249 FKPIMGKVMEIFRPGAVVLQCGADSLSGDRLGCFNLSIKGHAECVKFMRSFNVPLLLLGG 308
Query: 287 -------------YSSGLKKGFPAFIRGYEEDKVRDHAQPSY 315
Y +G+ G EDK+ +H Y
Sbjct: 309 GGYTIRNVARCWCYETGVALGVEV------EDKMPEHEYYEY 344
>pir||T23963 hypothetical protein R06C1.1 - Caenorhabditis elegans
>gi|3878853|emb|CAB03224.1| (Z81106) contains similarity
to Pfam domain: PF00850 (Histone deacetylase family),
Score=575.1, E-value=1.4e-169, N=1~cDNA EST EMBL:M89215
comes from this gene~cDNA EST yk426h1.3 comes from this
gene~cDNA EST yk569h4.3 comes from this gene~cDNA EST
yk5> >gi|3879019|emb|CAB03240.1| (Z81108) contains
similarity to Pfam domain: PF00850 (Histone deacetylase
family), Score=575.1, E-value=1.4e-169, N=1~cDNA EST
EMBL:M89215 comes from this gene~cDNA EST yk426h1.3
comes from this gene~cDNA EST yk569h4.3 comes from this
gene~cDNA EST yk5>
Length = 465
Score = 91.7 bits (224), Expect = 1e-17
Identities = 69/279 (24%), Positives = 125/279 (44%), Gaps = 18/279 (6%)
Query: 20 HPENPGRLWLVLTAIRELGLEN--HVLEPSPIGEELIYRIHEREYVEKIREL-SRRGGGY 76
HP P R+ + + I GL +V+ P+ I R H +Y+ +R + S +
Sbjct: 27 HPMKPHRVRMTHSLIVNYGLYRKLNVMRPARASFSEITRYHSDDYINFLRNVKSDNMSTF 86
Query: 77 LDA--------DTYVSPRTWEAAILALGASRLATLSALRYGGMNLALVRPPGHHAGRRGK 128
D D V +E L+ G S LA + L +A+ G H ++ +
Sbjct: 87 TDQMARFSVGEDCPVFDGMYEFCQLSCGGS-LAAAARLNRQESEIAINWMGGLHHAKKSE 145
Query: 129 ALGAPTLGFCIFNNSAMAALTSKEETGKALVIDFDAHHGNGTQEIFWDDADVVHIDLHER 188
A G FC N+ +A L + + L ID D HHG+G +E F+ V+ + H+
Sbjct: 146 ASG-----FCYSNDIVLAILELLKHHKRVLYIDIDVHHGDGVEEAFYTTDRVMTVSFHKH 200
Query: 189 -DIYPGSGDVGEIGGINAKGSKINLPMPHYSEDGDYIYAWEEVVIPIVEEVKPKVVIVSA 247
+ +PG+GD+ ++G + K +N+P+ +D Y + ++ ++ +P+ V++
Sbjct: 201 GEYFPGTGDLKDVGAGSGKYYALNVPLRDGVDDVTYERIFRTIMGEVMARFQPEAVVLQC 260
Query: 248 GFDGFKGDGLTTLKLTEVFYSYAGATLRKYPLAVILEGG 286
G D GD L LT + ++ + + ++L GG
Sbjct: 261 GADSLAGDRLGVFNLTTYGHGKCVEYMKSFNVPLLLVGG 299
>gi|6680195 histone deacetylase 2 [Mus musculus]
>gi|3023934|sp|P70288|HDA2_MOUSE HISTONE DEACETYLASE 2
(HD2) (YY1 TRANSCRIPTION FACTOR BINDING PROTEIN)
>gi|1667396|gb|AAC52889.1| (U31758) transcriptional
regulator homolog RPD3 [Mus musculus]
Length = 488
Score = 90.9 bits (222), Expect = 2e-17
Identities = 73/297 (24%), Positives = 130/297 (43%), Gaps = 27/297 (9%)
Query: 2 IGEIYYSRKFLLHKPDNYHPENPGRLWLVLTAIRELGL--ENHVLEPSPIGEELIYRIHE 59
IG YY + HP P R+ + + GL + + P E + + H
Sbjct: 20 IGNYYYGQG---------HPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATAEEMTKYHS 70
Query: 60 REYVEKIR--------ELSRRGGGY-LDADTYVSPRTWEAAILALGASRLATLSALRYGG 110
EY++ +R E S++ + + D V +E L+ G S +A L
Sbjct: 71 DEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGS-VAGAVKLNRQQ 129
Query: 111 MNLALVRPPGHHAGRRGKALGAPTLGFCIFNNSAMAALTSKEETGKALVIDFDAHHGNGT 170
++A+ G H ++ +A G FC N+ +A L + + L ID D HHG+G
Sbjct: 130 TDMAVNWAGGLHHAKKSEASG-----FCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGV 184
Query: 171 QEIFWDDADVVHIDLHER-DIYPGSGDVGEIGGINAKGSKINLPMPHYSEDGDYIYAWEE 229
+E F+ V+ + H+ + +PG+GD+ +IG K +N PM +D Y ++
Sbjct: 185 EEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQIFKP 244
Query: 230 VVIPIVEEVKPKVVIVSAGFDGFKGDGLTTLKLTEVFYSYAGATLRKYPLAVILEGG 286
++ ++E +P V++ G D GD L LT ++ + + L +++ GG
Sbjct: 245 IISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVAKTFNLPLLMLGG 301
>sp|P56517|HDA1_CHICK HISTONE DEACETYLASE 1 (HD1) >gi|2791684|gb|AAB96923.1| (AF039751)
histone deacetylase-1; HD-1 [Gallus gallus]
>gi|2829214|gb|AAC00504.1| (AF044169) erythrocyte
histone deacetylase [Gallus gallus]
Length = 480
Score = 90.5 bits (221), Expect = 3e-17
Identities = 71/297 (23%), Positives = 132/297 (43%), Gaps = 27/297 (9%)
Query: 2 IGEIYYSRKFLLHKPDNYHPENPGRLWLVLTAIRELGL--ENHVLEPSPIGEELIYRIHE 59
+G YY + HP P R+ + + GL + + P E + + H
Sbjct: 19 VGNYYYGQG---------HPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHS 69
Query: 60 REYVEKIR--------ELSRRGGGY-LDADTYVSPRTWEAAILALGASRLATLSALRYGG 110
+Y++ +R E S++ + + D V +E L+ G S +A+ L
Sbjct: 70 DDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSAGGS-VASAVKLNKQQ 128
Query: 111 MNLALVRPPGHHAGRRGKALGAPTLGFCIFNNSAMAALTSKEETGKALVIDFDAHHGNGT 170
++A+ G H ++ +A G FC N+ +A L + + L ID D HHG+G
Sbjct: 129 TDIAVNWAGGLHHAKKSEASG-----FCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGV 183
Query: 171 QEIFWDDADVVHIDLHER-DIYPGSGDVGEIGGINAKGSKINLPMPHYSEDGDYIYAWEE 229
+E F+ V+ + H+ + +PG+GD+ +IG K +N P+ +D Y ++
Sbjct: 184 EEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKP 243
Query: 230 VVIPIVEEVKPKVVIVSAGFDGFKGDGLTTLKLTEVFYSYAGATLRKYPLAVILEGG 286
V+ ++E +P V++ G D GD L LT ++ ++ + L +++ GG
Sbjct: 244 VISKVMETFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGG 300
>gb|AAB99850.1| (AF043328) histone deacetylase 1 [Gallus gallus]
Length = 480
Score = 90.5 bits (221), Expect = 3e-17
Identities = 71/297 (23%), Positives = 132/297 (43%), Gaps = 27/297 (9%)
Query: 2 IGEIYYSRKFLLHKPDNYHPENPGRLWLVLTAIRELGL--ENHVLEPSPIGEELIYRIHE 59
+G YY + HP P R+ + + GL + + P E + + H
Sbjct: 19 VGNYYYGQG---------HPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHS 69
Query: 60 REYVEKIR--------ELSRRGGGY-LDADTYVSPRTWEAAILALGASRLATLSALRYGG 110
+Y++ +R E S++ + + D V +E L+ G S +A+ L
Sbjct: 70 DDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSAGGS-VASAVKLNKQQ 128
Query: 111 MNLALVRPPGHHAGRRGKALGAPTLGFCIFNNSAMAALTSKEETGKALVIDFDAHHGNGT 170
++A+ G H ++ +A G FC N+ +A L + + L ID D HHG+G
Sbjct: 129 TDIAVNWAGGLHHAKKSEASG-----FCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGV 183
Query: 171 QEIFWDDADVVHIDLHER-DIYPGSGDVGEIGGINAKGSKINLPMPHYSEDGDYIYAWEE 229
+E F+ V+ + H+ + +PG+GD+ +IG K +N P+ +D Y ++
Sbjct: 184 EEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKP 243
Query: 230 VVIPIVEEVKPKVVIVSAGFDGFKGDGLTTLKLTEVFYSYAGATLRKYPLAVILEGG 286
V+ ++E +P V++ G D GD L LT ++ ++ + L +++ GG
Sbjct: 244 VISKVMETFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGG 300
>gb|AAD10139.1| (AF045473) histone deacetylase [Zea mays]
Length = 458
Score = 90.5 bits (221), Expect = 3e-17
Identities = 74/301 (24%), Positives = 127/301 (41%), Gaps = 29/301 (9%)
Query: 2 IGEIYYSRKFLLHKPDNYHPENPGRLWLVLTAIRELGLEN--HVLEPSPIGEELIYRIHE 59
IG+ YY + HP P R+ + + + GL + P P E I R H
Sbjct: 32 IGDYYYGQG---------HPMKPHRIRMAHSLVVHYGLHRLLELSRPYPASEADIRRFHS 82
Query: 60 REYVEKIRELSRRGGGYLDADTYVSPRTWEAAILALGASRLATLSA---------LRYGG 110
+YV + + G LD E + G SA L G
Sbjct: 83 DDYVAFLASATGNPG-VLDPRAIKRFNVGEDCPVFDGLFPFCQASAGGSIGAAVKLNRGD 141
Query: 111 MNLALVRPPGHHAGRRGKALGAPTLGFCIFNNSAMAALTSKEETGKALVIDFDAHHGNGT 170
++ + G H ++ +A G FC N+ +A L + + L +D D HHG+G
Sbjct: 142 ADITVNWAGGLHHAKKSEASG-----FCYVNDIVLAILELLKFHRRVLYVDIDVHHGDGV 196
Query: 171 QEIFWDDADVVHIDLHER-DIYPGSGDVGEIGGINAKGSKINLPMPHYSEDGDYIYAWEE 229
+E F+ V+ + H+ D +PG+G + ++G K +N+P+ +D + ++
Sbjct: 197 EEAFFTTNRVMTVSFHKYGDFFPGTGHITDVGAAEGKHYALNVPLSDGIDDTTFRGLFQC 256
Query: 230 VVIPIVEEVKPKVVIVSAGFDGFKGDGLTTLKLTEVFYSYAGATLRKY--PLAVILEGGY 287
++ ++E +P VV++ G D GD L L+ ++ LR Y P+ V+ GGY
Sbjct: 257 IIKKVMEVYQPDVVVLQCGADSLAGDRLGCFNLSVKGHADCLRFLRSYNVPMMVLGGGGY 316
Query: 288 S 288
+
Sbjct: 317 T 317
>emb|CAA62950.1| (X91837) putative transcriptional regulator [Saccharomyces
cerevisiae]
Length = 452
Score = 89.3 bits (218), Expect = 6e-17
Identities = 71/286 (24%), Positives = 120/286 (41%), Gaps = 24/286 (8%)
Query: 20 HPENPGRLWLVLTAIRELGLEN--HVLEPSPIGEELIYRIHEREYVEKIRELSRRGGGYL 77
HP P RL L + GL + E + + + H +YV + ++S L
Sbjct: 45 HPMKPFRLMLTDHLVSSYGLHKIMDLYETRSATRDELLQFHSEDYVNFLSKVSPENANKL 104
Query: 78 DADTY----------VSPRTWEAAILALGASRLATLSALRYGGMNLALVRPPG-HHAGRR 126
T + ++ L GAS AT + ++A+ G HHA +
Sbjct: 105 PRGTLENFNIGDDCPIFQNLYDYTTLYTGASLDATRKLIN-NQSDIAINWSGGLHHAKKN 163
Query: 127 GKALGAPTLGFCIFNNSAMAALTSKEETGKALVIDFDAHHGNGTQEIFWDDADVVHIDLH 186
+ GFC N+ ++ L + L ID D HHG+G QE F+ V + H
Sbjct: 164 SPS------GFCYVNDIVLSILNLLRYHPRILYIDIDLHHGDGVQEAFYTTDRVFTLSFH 217
Query: 187 ER--DIYPGSGDVGEIGGINAKGSKINLPMPHYSEDGDYIYAWEEVVIPIVEEVKPKVVI 244
+ + +PG+GD+ EIG K +N+P+ +D YI ++ +V P++ KP +++
Sbjct: 218 KYNGEFFPGTGDLTEIGCDKGKHFALNVPLEDGIDDDSYINLFKSIVDPLIMTFKPTLIV 277
Query: 245 VSAGFDGFKGDGLTTLKLTEVFYSYAGATLRKY--PLAVILEGGYS 288
G D D L L + ++ + P+ V+ GGY+
Sbjct: 278 QQCGADSLGHDRLGCFNLNIKAHGECVKFVKSFGLPMLVVGGGGYT 323
>sp|Q13547|HDA1_HUMAN HISTONE DEACETYLASE 1 (HD1) >gi|1277084|gb|AAC50475.1| (U50079)
histone deacetylase HD1 [Homo sapiens]
Length = 482
Score = 89.3 bits (218), Expect = 6e-17
Identities = 71/297 (23%), Positives = 132/297 (43%), Gaps = 27/297 (9%)
Query: 2 IGEIYYSRKFLLHKPDNYHPENPGRLWLVLTAIRELGL--ENHVLEPSPIGEELIYRIHE 59
+G YY + HP P R+ + + GL + + P E + + H
Sbjct: 19 VGNYYYGQG---------HPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHS 69
Query: 60 REYVEKIR--------ELSRRGGGY-LDADTYVSPRTWEAAILALGASRLATLSALRYGG 110
+Y++ +R E S++ + + D V +E L+ G S +A+ L
Sbjct: 70 DDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGS-VASAVKLNKQQ 128
Query: 111 MNLALVRPPGHHAGRRGKALGAPTLGFCIFNNSAMAALTSKEETGKALVIDFDAHHGNGT 170
++A+ G H ++ +A G FC N+ +A L + + L ID D HHG+G
Sbjct: 129 TDIAVNWAGGLHHAKKSEASG-----FCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGV 183
Query: 171 QEIFWDDADVVHIDLHER-DIYPGSGDVGEIGGINAKGSKINLPMPHYSEDGDYIYAWEE 229
+E F+ V+ + H+ + +PG+GD+ +IG K +N P+ +D Y ++
Sbjct: 184 EEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKP 243
Query: 230 VVIPIVEEVKPKVVIVSAGFDGFKGDGLTTLKLTEVFYSYAGATLRKYPLAVILEGG 286
V+ ++E +P V++ G D GD L LT ++ ++ + L +++ GG
Sbjct: 244 VMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGG 300
>gi|6321244 (putative) histone deacetylase; Hos2p [Saccharomyces cerevisiae]
>gi|1723948|sp|P53096|HOS2_YEAST PROBABLE HISTONE
DEACETYLASE HOS2 >gi|2133059|pir||S64211 probable
transcription regulator YGL194c - yeast (Saccharomyces
cerevisiae) >gi|1322819|emb|CAA96906.1| (Z72716) ORF
YGL194c [Saccharomyces cerevisiae]
Length = 452
Score = 89.3 bits (218), Expect = 6e-17
Identities = 71/286 (24%), Positives = 120/286 (41%), Gaps = 24/286 (8%)
Query: 20 HPENPGRLWLVLTAIRELGLEN--HVLEPSPIGEELIYRIHEREYVEKIRELSRRGGGYL 77
HP P RL L + GL + E + + + H +YV + ++S L
Sbjct: 45 HPMKPFRLMLTDHLVSSYGLHKIMDLYETRSATRDELLQFHSEDYVNFLSKVSPENANKL 104
Query: 78 DADTY----------VSPRTWEAAILALGASRLATLSALRYGGMNLALVRPPG-HHAGRR 126
T + ++ L GAS AT + ++A+ G HHA +
Sbjct: 105 PRGTLENFNIGDDCPIFQNLYDYTTLYTGASLDATRKLIN-NQSDIAINWSGGLHHAKKN 163
Query: 127 GKALGAPTLGFCIFNNSAMAALTSKEETGKALVIDFDAHHGNGTQEIFWDDADVVHIDLH 186
+ GFC N+ ++ L + L ID D HHG+G QE F+ V + H
Sbjct: 164 SPS------GFCYVNDIVLSILNLLRYHPRILYIDIDLHHGDGVQEAFYTTDRVFTLSFH 217
Query: 187 ER--DIYPGSGDVGEIGGINAKGSKINLPMPHYSEDGDYIYAWEEVVIPIVEEVKPKVVI 244
+ + +PG+GD+ EIG K +N+P+ +D YI ++ +V P++ KP +++
Sbjct: 218 KYNGEFFPGTGDLTEIGCDKGKHFALNVPLEDGIDDDSYINLFKSIVDPLIMTFKPTLIV 277
Query: 245 VSAGFDGFKGDGLTTLKLTEVFYSYAGATLRKY--PLAVILEGGYS 288
G D D L L + ++ + P+ V+ GGY+
Sbjct: 278 QQCGADSLGHDRLGCFNLNIKAHGECVKFVKSFGLPMLVVGGGGYT 323
>gi|4826756 histone deacetylase 1; RPD3 (reduced potassium dependency, yeast,
homolog)-like 1 [Homo sapiens]
>gi|1665723|dbj|BAA08909.1| (D50405) RPD3 protein [Homo
sapiens]
Length = 482
Score = 89.3 bits (218), Expect = 6e-17
Identities = 71/297 (23%), Positives = 132/297 (43%), Gaps = 27/297 (9%)
Query: 2 IGEIYYSRKFLLHKPDNYHPENPGRLWLVLTAIRELGL--ENHVLEPSPIGEELIYRIHE 59
+G YY + HP P R+ + + GL + + P E + + H
Sbjct: 19 VGNYYYGQG---------HPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHS 69
Query: 60 REYVEKIR--------ELSRRGGGY-LDADTYVSPRTWEAAILALGASRLATLSALRYGG 110
+Y++ +R E S++ + + D V +E L+ G S +A+ L
Sbjct: 70 DDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGS-VASAVKLNKQQ 128
Query: 111 MNLALVRPPGHHAGRRGKALGAPTLGFCIFNNSAMAALTSKEETGKALVIDFDAHHGNGT 170
++A+ G H ++ +A G FC N+ +A L + + L ID D HHG+G
Sbjct: 129 TDIAVNWAGGLHHAKKSEASG-----FCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGV 183
Query: 171 QEIFWDDADVVHIDLHER-DIYPGSGDVGEIGGINAKGSKINLPMPHYSEDGDYIYAWEE 229
+E F+ V+ + H+ + +PG+GD+ +IG K +N P+ +D Y ++
Sbjct: 184 EEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKP 243
Query: 230 VVIPIVEEVKPKVVIVSAGFDGFKGDGLTTLKLTEVFYSYAGATLRKYPLAVILEGG 286
V+ ++E +P V++ G D GD L LT ++ ++ + L +++ GG
Sbjct: 244 VMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGG 300
>gi|6680193 histone deacetylase 1 [Mus musculus]
>gi|2498444|sp|O09106|HDA1_MOUSE HISTONE DEACETYLASE 1
(HD1) >gi|1771286|emb|CAA66870.1| (X98207) histone
deacetylase [Mus musculus]
Length = 482
Score = 89.3 bits (218), Expect = 6e-17
Identities = 71/297 (23%), Positives = 132/297 (43%), Gaps = 27/297 (9%)
Query: 2 IGEIYYSRKFLLHKPDNYHPENPGRLWLVLTAIRELGL--ENHVLEPSPIGEELIYRIHE 59
+G YY + HP P R+ + + GL + + P E + + H
Sbjct: 19 VGNYYYGQG---------HPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHS 69
Query: 60 REYVEKIR--------ELSRRGGGY-LDADTYVSPRTWEAAILALGASRLATLSALRYGG 110
+Y++ +R E S++ + + D V +E L+ G S +A+ L
Sbjct: 70 DDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGS-VASAVKLNKQQ 128
Query: 111 MNLALVRPPGHHAGRRGKALGAPTLGFCIFNNSAMAALTSKEETGKALVIDFDAHHGNGT 170
++A+ G H ++ +A G FC N+ +A L + + L ID D HHG+G
Sbjct: 129 TDIAVNWAGGLHHAKKSEASG-----FCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGV 183
Query: 171 QEIFWDDADVVHIDLHER-DIYPGSGDVGEIGGINAKGSKINLPMPHYSEDGDYIYAWEE 229
+E F+ V+ + H+ + +PG+GD+ +IG K +N P+ +D Y ++
Sbjct: 184 EEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKP 243
Query: 230 VVIPIVEEVKPKVVIVSAGFDGFKGDGLTTLKLTEVFYSYAGATLRKYPLAVILEGG 286
V+ ++E +P V++ G D GD L LT ++ ++ + L +++ GG
Sbjct: 244 VMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGG 300
>sp|O17695|HDA1_CAEEL PROBABLE HISTONE DEACETYLASE 1 >gi|7497847|pir||T20163 hypothetical
protein C53A5.3 - Caenorhabditis elegans
>gi|3875199|emb|CAB03984.1| (Z81486) predicted using
Genefinder~Similarity to Yeast RPD3 transcriptional
regulatiry protein (SW:P32561), contains similarity to
Pfam domain: PF00850 (Histone deacetylase family),
Score=617.7, E-value=2.2e-182, N=1~cDNA EST EMBL:T02368
comes from th>
Length = 461
Score = 89.3 bits (218), Expect = 6e-17
Identities = 73/301 (24%), Positives = 130/301 (42%), Gaps = 29/301 (9%)
Query: 2 IGEIYYSRKFLLHKPDNYHPENPGRLWLVLTAIRELGLENH--VLEPSPIGEELIYRIHE 59
IG YY + H P R+ + + GL + + P P E + R H
Sbjct: 23 IGNYYYGQG---------HVMKPHRIRMTHHLVLNYGLYRNLEIFRPFPASFEDMTRFHS 73
Query: 60 REYV--------EKIRELSRRGGGY-LDADTYVSPRTWEAAILALGASRLATLSALRYGG 110
EY+ + ++ +++ + + D + +E L+ G S LA + L
Sbjct: 74 DEYMTFLKSANPDNLKSFNKQMLKFNVGEDCPLFDGLYEFCQLSSGGS-LAAATKLNKQK 132
Query: 111 MNLALVRPPGHHAGRRGKALGAPTLGFCIFNNSAMAALTSKEETGKALVIDFDAHHGNGT 170
+++A+ G H ++ +A G FC N+ + L + + L +D D HHG+G
Sbjct: 133 VDIAINWMGGLHHAKKSEASG-----FCYTNDIVLGILELLKYHKRVLYVDIDVHHGDGV 187
Query: 171 QEIFWDDADVVHIDLHER-DIYPGSGDVGEIGGINAKGSKINLPMPHYSEDGDYIYAWEE 229
+E F+ V+ + H+ D +PG+GD+ +IG K +N+P+ D Y ++
Sbjct: 188 EEAFYTTDRVMTVSFHKYGDFFPGTGDLKDIGAGKGKLYSVNVPLRDGITDVSYQSIFKP 247
Query: 230 VVIPIVEEVKPKVVIVSAGFDGFKGDGLTTLKLTEVFYSYAGATLRKY--PLAVILEGGY 287
++ ++E P V++ G D GD L LT + R Y PL ++ GGY
Sbjct: 248 IMTKVMERFDPCAVVLQCGADSLNGDRLGPFNLTLKGHGECARFFRSYNVPLMMVGGGGY 307
Query: 288 S 288
+
Sbjct: 308 T 308
>gb|AAB68398.1| (U80780) putative histone deacetylase [Mus musculus]
Length = 482
Score = 88.9 bits (217), Expect = 8e-17
Identities = 71/297 (23%), Positives = 132/297 (43%), Gaps = 27/297 (9%)
Query: 2 IGEIYYSRKFLLHKPDNYHPENPGRLWLVLTAIRELGL--ENHVLEPSPIGEELIYRIHE 59
+G YY + HP P R+ + + GL + + P E + + H
Sbjct: 19 VGNYYYGQG---------HPMXPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHS 69
Query: 60 REYVEKIR--------ELSRRGGGY-LDADTYVSPRTWEAAILALGASRLATLSALRYGG 110
+Y++ +R E S++ + + D V +E L+ G S +A+ L
Sbjct: 70 DDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGS-VASAVKLNKQQ 128
Query: 111 MNLALVRPPGHHAGRRGKALGAPTLGFCIFNNSAMAALTSKEETGKALVIDFDAHHGNGT 170
++A+ G H ++ +A G FC N+ +A L + + L ID D HHG+G
Sbjct: 129 TDIAVNWAGGLHHAKKSEASG-----FCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGV 183
Query: 171 QEIFWDDADVVHIDLHER-DIYPGSGDVGEIGGINAKGSKINLPMPHYSEDGDYIYAWEE 229
+E F+ V+ + H+ + +PG+GD+ +IG K +N P+ +D Y ++
Sbjct: 184 EEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKP 243
Query: 230 VVIPIVEEVKPKVVIVSAGFDGFKGDGLTTLKLTEVFYSYAGATLRKYPLAVILEGG 286
V+ ++E +P V++ G D GD L LT ++ ++ + L +++ GG
Sbjct: 244 VMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGG 300
>sp|P56518|HDA1_STRPU HISTONE DEACETYLASE 1 (HD1) >gi|2654077|gb|AAB87685.1| (AF032919)
histone deacetylase [Strongylocentrotus purpuratus]
Length = 576
Score = 88.9 bits (217), Expect = 8e-17
Identities = 72/297 (24%), Positives = 131/297 (43%), Gaps = 27/297 (9%)
Query: 2 IGEIYYSRKFLLHKPDNYHPENPGRLWLVLTAIRELGL--ENHVLEPSPIGEELIYRIHE 59
+G YY + HP P R+ + I GL + + P E + + H
Sbjct: 18 VGNYYYGQG---------HPMKPHRIRMTHNLILNYGLYRKMEIYRPHKAVMEEMTKYHS 68
Query: 60 REYVEKIR--------ELSRRGGGY-LDADTYVSPRTWEAAILALGASRLATLSALRYGG 110
+YV+ +R E +++ + + D V +E L+ G S +A L
Sbjct: 69 DDYVKFLRTIRPDNMSEYTKQMQRFNVGEDCPVFDGLYEFCQLSSGGS-VAGAVKLNKQQ 127
Query: 111 MNLALVRPPGHHAGRRGKALGAPTLGFCIFNNSAMAALTSKEETGKALVIDFDAHHGNGT 170
++A+ G H ++ +A G FC N+ +A L + + L ID D HHG+G
Sbjct: 128 TDIAINWAGGLHHAKKSEASG-----FCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGV 182
Query: 171 QEIFWDDADVVHIDLHER-DIYPGSGDVGEIGGINAKGSKINLPMPHYSEDGDYIYAWEE 229
+E F+ V+ + H+ + +PG+GD+ +IG K +N P+ +D Y ++
Sbjct: 183 EEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPLRDGIDDESYDKIFKP 242
Query: 230 VVIPIVEEVKPKVVIVSAGFDGFKGDGLTTLKLTEVFYSYAGATLRKYPLAVILEGG 286
++ ++E +P + + G D GD L LT ++ +++Y L ++L GG
Sbjct: 243 IMCKVMEMYQPSAICLQCGADSLSGDRLGCFNLTLKGHAKCVEFMKQYNLPLLLMGG 299
>gb|AAC61494.1| (AF086715) putative histone deacetylase [Drosophila melanogaster]
Length = 521
Score = 88.9 bits (217), Expect = 8e-17
Identities = 70/297 (23%), Positives = 123/297 (40%), Gaps = 27/297 (9%)
Query: 2 IGEIYYSRKFLLHKPDNYHPENPGRLWLVLTAIRELGL--ENHVLEPSPIGEELIYRIHE 59
IG YY + HP P R+ + + GL + + P + + + H
Sbjct: 17 IGNYYYGQG---------HPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATADEMTKFHS 67
Query: 60 REYVEKIREL---------SRRGGGYLDADTYVSPRTWEAAILALGASRLATLSALRYGG 110
EYV +R + + + D V +E L+ G S A + L
Sbjct: 68 DEYVRFLRSIRPDNMSEYNKQMQRFNVGEDCPVFDGLYEFCQLSAGGSVAAAVK-LNKQA 126
Query: 111 MNLALVRPPGHHAGRRGKALGAPTLGFCIFNNSAMAALTSKEETGKALVIDFDAHHGNGT 170
+ + G H ++ +A G FC N+ + L + + L ID D HHG+G
Sbjct: 127 SEICINWGGGLHHAKKSEASG-----FCYVNDIVLGILELLKYHQRVLYIDIDVHHGDGV 181
Query: 171 QEIFWDDADVVHIDLHER-DIYPGSGDVGEIGGINAKGSKINLPMPHYSEDGDYIYAWEE 229
+E F+ V+ + H+ + +PG+GD+ +IG K +N+P+ +D Y +
Sbjct: 182 EEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNIPLRDGMDDDAYESIFVP 241
Query: 230 VVIPIVEEVKPKVVIVSAGFDGFKGDGLTTLKLTEVFYSYAGATLRKYPLAVILEGG 286
++ ++E +P V++ G D GD L LT + ++KY L ++ GG
Sbjct: 242 IISKVMETFQPAAVVLQCGADSLTGDRLGCFNLTVKGHGKCVEFVKKYNLPFLMVGG 298
>gb|AAF47924.1| (AE003482) Rpd3 gene product [Drosophila melanogaster]
Length = 521
Score = 88.9 bits (217), Expect = 8e-17
Identities = 70/297 (23%), Positives = 123/297 (40%), Gaps = 27/297 (9%)
Query: 2 IGEIYYSRKFLLHKPDNYHPENPGRLWLVLTAIRELGL--ENHVLEPSPIGEELIYRIHE 59
IG YY + HP P R+ + + GL + + P + + + H
Sbjct: 17 IGNYYYGQG---------HPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATADEMTKFHS 67
Query: 60 REYVEKIREL---------SRRGGGYLDADTYVSPRTWEAAILALGASRLATLSALRYGG 110
EYV +R + + + D V +E L+ G S A + L
Sbjct: 68 DEYVRFLRSIRPDNMSEYNKQMQRFNVGEDCPVFDGLYEFCQLSAGGSVAAAVK-LNKQA 126
Query: 111 MNLALVRPPGHHAGRRGKALGAPTLGFCIFNNSAMAALTSKEETGKALVIDFDAHHGNGT 170
+ + G H ++ +A G FC N+ + L + + L ID D HHG+G
Sbjct: 127 SEICINWGGGLHHAKKSEASG-----FCYVNDIVLGILELLKYHQRVLYIDIDVHHGDGV 181
Query: 171 QEIFWDDADVVHIDLHER-DIYPGSGDVGEIGGINAKGSKINLPMPHYSEDGDYIYAWEE 229
+E F+ V+ + H+ + +PG+GD+ +IG K +N+P+ +D Y +
Sbjct: 182 EEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNIPLRDGMDDDAYESIFVP 241
Query: 230 VVIPIVEEVKPKVVIVSAGFDGFKGDGLTTLKLTEVFYSYAGATLRKYPLAVILEGG 286
++ ++E +P V++ G D GD L LT + ++KY L ++ GG
Sbjct: 242 IISKVMETFQPAAVVLQCGADSLTGDRLGCFNLTVKGHGKCVEFVKKYNLPFLMVGG 298
>gb|AAG00980.1| (AF276431) histone deacetylase I [Tetrahymena thermophila]
Length = 429
Score = 88.5 bits (216), Expect = 1e-16
Identities = 70/288 (24%), Positives = 125/288 (43%), Gaps = 27/288 (9%)
Query: 18 NYHPENPGRLWLVLTAIRELGLE---NHVLEP------SPIGEELIYRIHEREYVEKIRE 68
N HP P R+ + T +R ++ NH + E+++ H EY+E I++
Sbjct: 34 NPHPMKPHRVAMTDTLVRSYEIDKKMNHFDRDYVNTYIRAVNEKILTNFHSDEYIELIQK 93
Query: 69 LSRRGGGYLDADTY---------VSPRTWEAAILALGASRLATLSALRYGGMNLALVRPP 119
+ + + Y V R ++ L A +A + L +++AL
Sbjct: 94 VHPNNKHFYEDQLYRFNFGEDCPVLDRLYDYC-LTYAAGSVAGANLLANQKVDIALNWSG 152
Query: 120 GHHAGRRGKALGAPTLGFCIFNNSAMAALTS-KEETGKALVIDFDAHHGNGTQEIFWDDA 178
G H ++ +A G FC N+ +A L K + L ID D HHG+G +E D
Sbjct: 153 GLHHAKQSEASG-----FCYINDCVLAILELLKPFIQRVLYIDIDIHHGDGVEEYLTDR- 206
Query: 179 DVVHIDLHERDIYPGSGDVGEIGGINAKGSKINLPMPHYSEDGDYIYAWEEVVIPIVEEV 238
V+ H+ I+PG+G + +IG K +N P+ +D ++ V+ I++
Sbjct: 207 -VMTSSFHKYKIFPGTGHLDDIGTQQGKFHAVNFPLNEGLDDQSICLYYKPVLQKIMDTF 265
Query: 239 KPKVVIVSAGFDGFKGDGLTTLKLTEVFYSYAGATLRKYPLAVILEGG 286
+P+ V++ G D GD L L+ + ++ + + +IL GG
Sbjct: 266 RPEAVVLQCGADSLSGDRLGCFNLSIKGHGECATFMKSFGVPIILLGG 313
>sp|Q94517|HDAC_DROME PROBABLE HISTONE DEACETYLASE (HD) (DRPD3)
>gi|1666637|emb|CAA70455.1| (Y09258) histone deacetylase
[Drosophila melanogaster]
Length = 520
Score = 88.2 bits (215), Expect = 1e-16
Identities = 71/303 (23%), Positives = 126/303 (41%), Gaps = 26/303 (8%)
Query: 2 IGEIYYSRKFLLHKPDNYHPENPGRLWLVLTAIRELGLENHV-LEPSPIGEELIYRIHER 60
IG YY + HP P R+ + + GL + + P + + + H
Sbjct: 17 IGNYYYGQG---------HPMKPHRIRMTHNLLLNYGLYRKMDIRPHKATADEMTKFHCD 67
Query: 61 EYVEKIREL---------SRRGGGYLDADTYVSPRTWEAAILALGASRLATLSALRYGGM 111
EYV +R + + + D V +E L+ G S A + L
Sbjct: 68 EYVRFLRSIRPDNMSEYNKQMQRFNVGEDCPVFDGLYEFCQLSAGGSVAAAVK-LNKQAS 126
Query: 112 NLALVRPPGHHAGRRGKALGAPTLGFCIFNNSAMAALTSKEETGKALVIDFDAHHGNGTQ 171
+ + G H ++ +A G FC N+ + L + + L ID D HHG+G +
Sbjct: 127 EICINWGGGLHHAKKSEASG-----FCYVNDIVLGILELLKYHQRVLYIDIDVHHGDGVE 181
Query: 172 EIFWDDADVVHIDLHER-DIYPGSGDVGEIGGINAKGSKINLPMPHYSEDGDYIYAWEEV 230
E F+ V+ + H+ + +PG+GD+ +IG K +N+P+ +D Y + +
Sbjct: 182 EAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNIPLRDGMDDDAYESIFVPI 241
Query: 231 VIPIVEEVKPKVVIVSAGFDGFKGDGLTTLKLTEVFYSYAGATLRKYPLAVILEGGYSSG 290
+ ++E +P V++ G D GD L LT + ++KY L ++ GG
Sbjct: 242 ISKVMETFQPAAVVLQCGADSLTGDRLGCFNLTVKGHGKCVEFVKKYNLPFLMVGGGGYT 301
Query: 291 LKK 293
++K
Sbjct: 302 IRK 304
>gi|8923769 histone deacetylase 8 [Homo sapiens] >gi|11419830|ref|XP_010133.1|
histone deacetylase 8 [Homo sapiens]
>gi|7710996|emb|CAB90213.1| (AJ277724) histone
deacetylase 8 [Homo sapiens] >gi|8118721|gb|AAF73076.1|
(AF230097) class I histone deacetylase [Homo sapiens]
Length = 377
Score = 88.2 bits (215), Expect = 1e-16
Identities = 63/275 (22%), Positives = 123/275 (43%), Gaps = 18/275 (6%)
Query: 24 PGRLWLVLTAIRELGLENH--VLEPSPIGEELIYRIHEREYVEKIRELSRRGGGY----- 76
P R +V + I L +++P E + H Y++ ++++S+ G
Sbjct: 35 PKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSI 94
Query: 77 ---LDADTYVSPRTWEAAILALGASRLATLSALRYGGMNLALVRPPGHHAGRRGKALGAP 133
L D + ++ A A+G + + L G +A+ G H ++ +A G
Sbjct: 95 EYGLGYDCPATEGIFDYAA-AIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASG-- 151
Query: 134 TLGFCIFNNSAMAALTSKEETGKALVIDFDAHHGNGTQEIFWDDADVVHIDLHERD--IY 191
FC N++ + L + + + L +D D HHG+G ++ F + V+ + LH+ +
Sbjct: 152 ---FCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFF 208
Query: 192 PGSGDVGEIGGINAKGSKINLPMPHYSEDGDYIYAWEEVVIPIVEEVKPKVVIVSAGFDG 251
PG+GDV ++G + +N+P+ +D Y E V+ + + PK V++ G D
Sbjct: 209 PGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADT 268
Query: 252 FKGDGLTTLKLTEVFYSYAGATLRKYPLAVILEGG 286
GD + + +T V + ++ LA ++ GG
Sbjct: 269 IAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGG 303
>gi|4557641 histone deacetylase 2 [Homo sapiens]
>gi|3023939|sp|Q92769|HDA2_HUMAN HISTONE DEACETYLASE 2
(HD2) >gi|1667394|gb|AAC50814.1| (U31814)
transcriptional regulator homolog RPD3 [Homo sapiens]
Length = 488
Score = 87.8 bits (214), Expect = 2e-16
Identities = 72/297 (24%), Positives = 130/297 (43%), Gaps = 27/297 (9%)
Query: 2 IGEIYYSRKFLLHKPDNYHPENPGRLWLVLTAIRELGL--ENHVLEPSPIGEELIYRIHE 59
IG YY + HP P R+ + + GL + + P E + + H
Sbjct: 20 IGNYYYGQG---------HPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATAEEMTKYHS 70
Query: 60 REYVEKIR--------ELSRRGGGY-LDADTYVSPRTWEAAILALGASRLATLSALRYGG 110
EY++ +R E S++ + + D +E L+ G S +A L
Sbjct: 71 DEYIKFLRSIRPDNMSEYSKQMHIFNVGEDCPAFDGLFEFCQLSTGGS-VAGAVKLNRQQ 129
Query: 111 MNLALVRPPGHHAGRRGKALGAPTLGFCIFNNSAMAALTSKEETGKALVIDFDAHHGNGT 170
++A+ G H ++ +A G FC N+ +A L + + L ID D HHG+G
Sbjct: 130 TDMAVNWAGGLHHAKKYEASG-----FCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGV 184
Query: 171 QEIFWDDADVVHIDLHER-DIYPGSGDVGEIGGINAKGSKINLPMPHYSEDGDYIYAWEE 229
+E F+ V+ + H+ + +PG+GD+ +IG K +N PM +D Y ++
Sbjct: 185 EEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMCDGIDDESYGQIFKP 244
Query: 230 VVIPIVEEVKPKVVIVSAGFDGFKGDGLTTLKLTEVFYSYAGATLRKYPLAVILEGG 286
++ ++E +P V++ G D GD L LT ++ ++ + L +++ GG
Sbjct: 245 IISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLGG 301
>sp|O42227|HD12_XENLA PROBABLE HISTONE DEACETYLASE 1-2 (HD1) (RPD3 HOMOLOG)
>gi|2444430|gb|AAC60346.1| (AF020658) deacetylase
[Xenopus laevis]
Length = 480
Score = 87.8 bits (214), Expect = 2e-16
Identities = 69/297 (23%), Positives = 132/297 (44%), Gaps = 27/297 (9%)
Query: 2 IGEIYYSRKFLLHKPDNYHPENPGRLWLVLTAIRELGL--ENHVLEPSPIGEELIYRIHE 59
+G YY + HP P R+ + + GL + + P E + + H
Sbjct: 19 VGNYYYGQG---------HPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKASAEEMTKYHS 69
Query: 60 REYVEKIR--------ELSRRGGGY-LDADTYVSPRTWEAAILALGASRLATLSALRYGG 110
+Y++ +R E S++ + + D V +E L+ G S +A+ L
Sbjct: 70 DDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGS-VASAVKLNKQQ 128
Query: 111 MNLALVRPPGHHAGRRGKALGAPTLGFCIFNNSAMAALTSKEETGKALVIDFDAHHGNGT 170
++++ G H ++ +A G FC N+ +A L + + + ID D HHG+G
Sbjct: 129 TDISVNWSGGLHHAKKSEASG-----FCYVNDIVLAILELLKYHQRVVYIDIDIHHGDGV 183
Query: 171 QEIFWDDADVVHIDLHER-DIYPGSGDVGEIGGINAKGSKINLPMPHYSEDGDYIYAWEE 229
+E F+ V+ + H+ + +PG+GD+ +IG K +N P+ +D Y ++
Sbjct: 184 EEAFYTTDRVMSVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKP 243
Query: 230 VVIPIVEEVKPKVVIVSAGFDGFKGDGLTTLKLTEVFYSYAGATLRKYPLAVILEGG 286
V+ ++E +P V++ G D GD L LT ++ ++ + L +++ GG
Sbjct: 244 VMTKVMEMFQPSAVVLQCGADSLSGDRLGCFNLTIKGHAKCVEFIKTFNLPMLMLGG 300
>dbj|BAB10553.1| (AB008265) histone deacetylase [Arabidopsis thaliana]
Length = 471
Score = 87.4 bits (213), Expect = 2e-16
Identities = 75/303 (24%), Positives = 128/303 (41%), Gaps = 31/303 (10%)
Query: 2 IGEIYYSRKFLLHKPDNYHPENPGRLWLVLTAIRELGLENH--VLEPSPIGEELIYRIHE 59
IG+ YY + HP P R+ + + I L + PS I R H
Sbjct: 29 IGDYYYGQG---------HPMKPHRIRMAHSLIIHYHLHRRLEISRPSLADASDIGRFHS 79
Query: 60 REYVEKIRELSRRGGGYLDA-----------DTYVSPRTWEAAILALGASRLATLSALRY 108
EYV+ + +S G A D V ++ + G S A + R
Sbjct: 80 PEYVDFLASVSPESMGDPSAARNLRRFNVGEDCPVFDGLFDFCRASAGGSIGAAVKLNRQ 139
Query: 109 GGMNLALVRPPGHHAGRRGKALGAPTLGFCIFNNSAMAALTSKEETGKALVIDFDAHHGN 168
++A+ G H ++ +A G FC N+ + L + + L ID D HHG+
Sbjct: 140 DA-DIAINWGGGLHHAKKSEASG-----FCYVNDIVLGILELLKMFKRVLYIDIDVHHGD 193
Query: 169 GTQEIFWDDADVVHIDLHE-RDIYPGSGDVGEIGGINAKGSKINLPMPHYSEDGDYIYAW 227
G +E F+ V+ + H+ D +PG+G + ++G K +N+P+ +D + +
Sbjct: 194 GVEEAFYTTDRVMTVSFHKFGDFFPGTGHIRDVGAEKGKYYALNVPLNDGMDDESFRSLF 253
Query: 228 EEVVIPIVEEVKPKVVIVSAGFDGFKGDGLTTLKLTEVFYSYAGATLRKY--PLAVILEG 285
++ ++E +P+ V++ G D GD L L+ ++ LR Y PL V+ G
Sbjct: 254 RPLIQKVMEVYQPEAVVLQCGADSLSGDRLGCFNLSVKGHADCLRFLRSYNVPLMVLGGG 313
Query: 286 GYS 288
GY+
Sbjct: 314 GYT 316
>sp|P56519|HDA2_CHICK HISTONE DEACETYLASE 2 (HD2) >gi|2791686|gb|AAB96924.1| (AF039752)
histone deacetylase-2; HD-2 [Gallus gallus]
Length = 488
Score = 86.6 bits (211), Expect = 4e-16
Identities = 72/297 (24%), Positives = 131/297 (43%), Gaps = 27/297 (9%)
Query: 2 IGEIYYSRKFLLHKPDNYHPENPGRLWLVLTAIRELGL--ENHVLEPSPIGEELIYRIHE 59
IG YY + HP P R+ + + GL + + P E + + H
Sbjct: 20 IGNYYYGQG---------HPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATAEEMTKYHS 70
Query: 60 REYVEKIR--------ELSRRGGGY-LDADTYVSPRTWEAAILALGASRLATLSALRYGG 110
EY++ +R E S++ + + D V +E L+ G S +A L
Sbjct: 71 DEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGS-VAGAVKLNRQQ 129
Query: 111 MNLALVRPPGHHAGRRGKALGAPTLGFCIFNNSAMAALTSKEETGKALVIDFDAHHGNGT 170
++A+ G H ++ +A G FC N+ +A L + + L ID D HHG+G
Sbjct: 130 TDMAVNWAGGLHHAKKSEASG-----FCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGV 184
Query: 171 QEIFWDDADVVHI-DLHERDIYPGSGDVGEIGGINAKGSKINLPMPHYSEDGDYIYAWEE 229
+E F+ V+ + ++ + +PG+GD+ +IG K +N PM +D Y ++
Sbjct: 185 EEAFYTTDRVMTVSEVSMVNNFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQIFKP 244
Query: 230 VVIPIVEEVKPKVVIVSAGFDGFKGDGLTTLKLTEVFYSYAGATLRKYPLAVILEGG 286
++ ++E +P V++ G D GD L LT ++ ++ + L +++ GG
Sbjct: 245 IISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLGG 301
>pir||T40300 histone deacetylase (EC 3.5.1.-) - fission yeast
(Schizosaccharomyces pombe) >gi|3135992|emb|CAA19053.1|
(AL023589) histone deacetylase [Schizosaccharomyces
pombe] >gi|4159997|gb|AAD05211.1| (AF064206) putative
histone deacetylase [Schizosaccharomyces pombe]
Length = 405
Score = 86.6 bits (211), Expect = 4e-16
Identities = 71/280 (25%), Positives = 123/280 (43%), Gaps = 20/280 (7%)
Query: 20 HPENPGRLWLVLTAIRELGLEN--HVLEPSPIGEELIYRIHEREYVEKIRELS------- 70
HP P R+ +V + L +V+ P + R H EY+E + ++
Sbjct: 25 HPMKPHRVRMVHNLVVNYNLYEKLNVITPVRATRNDMTRCHTDEYIEFLWRVTPDTMEKF 84
Query: 71 --RRGGGYLDADTYVSPRTWEAAILALGASRLATLSALRYGGMNLALVRPPG-HHAGRRG 127
+ + D V +E ++ G S + L G +A+ G HHA +R
Sbjct: 85 QPHQLKFNVGDDCPVFDGLYEFCSISAGGS-IGAAQELNSGNAEIAINWAGGLHHAKKRE 143
Query: 128 KALGAPTLGFCIFNNSAMAALTSKEETGKALVIDFDAHHGNGTQEIFWDDADVVHIDLHE 187
+ GFC N+ A+AAL + + L ID D HHG+G +E F+ V+ H+
Sbjct: 144 AS------GFCYVNDIALAALELLKYHQRVLYIDIDVHHGDGVEEFFYTTDRVMTCSFHK 197
Query: 188 -RDIYPGSGDVGEIGGINAKGSKINLPMPHYSEDGDYIYAWEEVVIPIVEEVKPKVVIVS 246
+ +PG+G + + G K +N+P+ +D Y ++ V+ I++ +P+ VI+
Sbjct: 198 FGEYFPGTGHIKDTGIGTGKNYAVNVPLRDGIDDESYESVFKPVISHIMQWFRPEAVILQ 257
Query: 247 AGFDGFKGDGLTTLKLTEVFYSYAGATLRKYPLAVILEGG 286
G D GD L L+ +S ++ + L +I GG
Sbjct: 258 CGTDSLAGDRLGCFNLSMKGHSMCVDFVKSFNLPMICVGG 297
>pir||T22134 hypothetical protein F43G6.4 - Caenorhabditis elegans
>gi|3979814|emb|CAA90401.1| (Z50070) contains similarity
to Pfam domain: PF00850 (Histone deacetylase family),
Score=477.8, E-value=2.9e-140, N=1~cDNA EST yk121c11.5
comes from this gene~cDNA EST yk121c11.3 comes from this
gene~cDNA EST yk443e6.3 comes from this gene~cDNA EST
yk4>
Length = 782
Score = 86.6 bits (211), Expect = 4e-16
Identities = 67/216 (31%), Positives = 106/216 (49%), Gaps = 27/216 (12%)
Query: 87 TWEAAILALGASRLATLSALRYGGMN--LALVRPPGHHAGRRGKALGAPTLGFCIFNNSA 144
T EAA +A+G S + + A G ++ A+VRPPGHH+ G G+CIFNN A
Sbjct: 372 TNEAARVAIGGS-IELVKAAMEGKIHNGFAMVRPPGHHS------YGKVAQGYCIFNNVA 424
Query: 145 MAA--LTSKEETGKALVIDFDAHHGNGTQEIFWDDADVVHIDLHERDI---YPGSGDVGE 199
+AA K E K ++DFD H GNGT + D++ + H +P S D
Sbjct: 425 IAAKYAIEKLEVKKVAIVDFDYHAGNGTYQSVKDESRIHLTSFHGHHFGAFWPFSRDYDY 484
Query: 200 IGGINAKGSKINLPMP---HYSEDGDYIYAWEEVVIPIVEEVKPKVVIVSAGFDGFKGDG 256
A S+ L +P + +GDY+ + V++P++E+ +P+++++SAGFD D
Sbjct: 485 -----ATNSQNTLFVPLNGTMNSEGDYVSVFHHVLLPMLEQFQPELILISAGFDSGYYDV 539
Query: 257 LTTLKLTEVFYSYAG-----ATLRKYPLAVILEGGY 287
+ + Y + + + ILEGGY
Sbjct: 540 MMEFGQGVKAHGYGHMARLLSQICPGKILAILEGGY 575
>gb|AAF82385.1| (AF282858) histone deacetylase [Mesembryanthemum crystallinum]
Length = 500
Score = 86.6 bits (211), Expect = 4e-16
Identities = 80/342 (23%), Positives = 139/342 (40%), Gaps = 52/342 (15%)
Query: 2 IGEIYYSRKFLLHKPDNYHPENPGRLWLVLTAIRELGLENH--VLEPSPIGEELIYRIHE 59
+G YY + HP P R+ + + GL H VL+P P + + R H
Sbjct: 27 VGNYYYGQG---------HPMKPHRIRMTHALLAHYGLLQHMQVLKPVPARDRDLCRFHA 77
Query: 60 REYV------------EKIRELSRRGGGYLDADTYVSPRTWEAAILALGASRLATLSALR 107
+YV +++R+L R G D V + G S + L
Sbjct: 78 DDYVSFLRGITPEMQQDQLRQLKRFNVG---EDCPVFDGLYSFCQTYAGGS-VGGAVKLN 133
Query: 108 YGGMNLALVRPPGHHAGRRGKALGAPTLGFCIFNNSAMAALTSKEETGKALVIDFDAHHG 167
+G ++A+ G H ++ +A G FC N+ +A L + + L +D D HHG
Sbjct: 134 HGLCDIAINWAGGLHHAKKSEASG-----FCYVNDIVLAILELLKVHERVLYVDIDIHHG 188
Query: 168 NGTQEIFWDDADVVHIDLHE-RDIYPGSGDVGEIGGINAKGSKINLPMPHYSEDGDYIYA 226
+G +E F+ V+ + H+ D +PG+ IG K +N+P+ +D Y
Sbjct: 189 DGVEEAFYTTERVMTVSFHKFGDYFPGTETFVYIGYGKGKYYSLNVPLDDGIDDESYQSL 248
Query: 227 WEEVVIPIVEEVKPKVVIVSAGFDGFKGDGLTTLKLTEVFYSYAGATLRKYPLAVILEGG 286
++ ++ ++E KP V++ G D GD L L+ ++ + + + ++L GG
Sbjct: 249 FKPIMGKVMEIFKPGAVVLQCGADSLSGDRLGCFNLSIKGHAECVKYMISFNVPLLLVGG 308
Query: 287 -------------YSSGLKKGFPAFIRGYEEDKVRDHAQPSY 315
Y +G+ GF +DK+ H Y
Sbjct: 309 GGYTIRYVARCWCYETGVALGFEL------DDKIPQHEYYEY 344
>gb|AAF73428.1|AF245664_1 (AF245664) histone deacetylase 8; HDAC8 [Homo sapiens]
Length = 377
Score = 86.2 bits (210), Expect = 5e-16
Identities = 63/275 (22%), Positives = 122/275 (43%), Gaps = 18/275 (6%)
Query: 24 PGRLWLVLTAIRELGLENH--VLEPSPIGEELIYRIHEREYVEKIRELSRRGGGY----- 76
P R +V + I L +++P E + H Y++ ++++S+ G
Sbjct: 35 PKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSI 94
Query: 77 ---LDADTYVSPRTWEAAILALGASRLATLSALRYGGMNLALVRPPGHHAGRRGKALGAP 133
L D + ++ A A+G + + L G +A+ G H ++ +A G
Sbjct: 95 EYGLGYDCPATEGIFDYAA-AIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASG-- 151
Query: 134 TLGFCIFNNSAMAALTSKEETGKALVIDFDAHHGNGTQEIFWDDADVVHIDLHE--RDIY 191
FC N++ + L + + + L +D D HHG+G ++ F + V+ + LH+ +
Sbjct: 152 ---FCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFF 208
Query: 192 PGSGDVGEIGGINAKGSKINLPMPHYSEDGDYIYAWEEVVIPIVEEVKPKVVIVSAGFDG 251
PG+GDV ++G +N+P+ +D Y E V+ + + PK V++ G D
Sbjct: 209 PGTGDVSDVGLGKGWYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADT 268
Query: 252 FKGDGLTTLKLTEVFYSYAGATLRKYPLAVILEGG 286
GD + + +T V + ++ LA ++ GG
Sbjct: 269 IAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGG 303
>gi|6323999 histone deacetylase; Rpd3p [Saccharomyces cerevisiae]
>gi|417699|sp|P32561|RPD3_YEAST HISTONE DEACETYLASE RPD3
(TRANSCRIPTIONAL REGULATORY PROTEIN RPD3)
>gi|83513|pir||S22284 transcription regulator RPD3 -
yeast (Saccharomyces cerevisiae)
>gi|238962|gb|AAB20328.1| (S66438) RPD3 [Saccharomyces
cerevisiae, Peptide, 433 aa] >gi|642338|emb|CAA58228.1|
(X83226) global transcriptional regulator [Saccharomyces
cerevisiae] >gi|1302451|emb|CAA96263.1| (Z71606) ORF
YNL330c [Saccharomyces cerevisiae]
Length = 433
Score = 85.4 bits (208), Expect = 9e-16
Identities = 67/283 (23%), Positives = 127/283 (44%), Gaps = 20/283 (7%)
Query: 20 HPENPGRLWLVLTAIRELGL--ENHVLEPSPIGEELIYRIHEREYVEKIR-------ELS 70
HP P R+ + + I GL + + P ++ + + H EY++ + E+
Sbjct: 38 HPMKPHRIRMAHSLIMNYGLYKKMEIYRAKPATKQEMCQFHTDEYIDFLSRVTPDNLEMF 97
Query: 71 RRGGGYLDA--DTYVSPRTWEAAILALGASRLATLSALRYGGMNLALVRPPGHHAGRRGK 128
+R + D V +E ++ G S + + L G ++A+ G H ++ +
Sbjct: 98 KRESVKFNVGDDCPVFDGLYEYCSISGGGS-MEGAARLNRGKCDVAVNYAGGLHHAKKSE 156
Query: 129 ALGAPTLGFCIFNNSAMAALTSKEETGKALVIDFDAHHGNGTQEIFWDDADVVHIDLHER 188
A G FC N+ + + + L ID D HHG+G +E F+ V+ H+
Sbjct: 157 ASG-----FCYLNDIVLGIIELLRYHPRVLYIDIDVHHGDGVEEAFYTTDRVMTCSFHKY 211
Query: 189 -DIYPGSGDVGEIGGINAKGSKINLPMPHYSEDGDYIYAWEEVVIPIVEEVKPKVVIVSA 247
+ +PG+G++ +IG K +N+P+ +D Y +E V+ I+E +P V++
Sbjct: 212 GEFFPGTGELRDIGVGAGKNYAVNVPLRDGIDDATYRSVFEPVIKKIMEWYQPSAVVLQC 271
Query: 248 GFDGFKGDGLTTLKLTEVFYSYAGATLRKY--PLAVILEGGYS 288
G D GD L L+ ++ ++ + P+ V+ GGY+
Sbjct: 272 GGDSLSGDRLGCFNLSMEGHANCVNYVKSFGIPMMVVGGGGYT 314
>sp|O13298|PHD1_SCHPO PROBABLE HISTONE DEACETYLASE PHD1 >gi|7444260|pir||T11643 histone
deacetylase (EC 3.5.1.-) - fission yeast
(Schizosaccharomyces pombe) >gi|2641699|dbj|BAA23598.1|
(AB008888) Phd1p [Schizosaccharomyces pombe]
>gi|2706458|emb|CAA15916.1| (AL021046) histone
deacetylase [Schizosaccharomyces pombe]
Length = 434
Score = 85.4 bits (208), Expect = 9e-16
Identities = 69/286 (24%), Positives = 124/286 (43%), Gaps = 25/286 (8%)
Query: 20 HPENPGRLWLVLTAIRELGLENHVLEPSP----IGEELIYRIHEREYVEKIRELSRRGGG 75
HP P R+ + + GL N + SP GE + H +Y++ ++ ++
Sbjct: 45 HPMKPHRITITNHLVMGYGLHNKMSVFSPRMATFGE--MSEFHREDYLDFLKRVTPDNAE 102
Query: 76 Y---------LDADTYVSPRTWEAAILALGASRLATLSALRYGGMNLALVRPPGHHAGRR 126
+ D V T+E + + GAS A+ ++ G ++A+ G H +R
Sbjct: 103 QFADKFQQFNIGDDCPVFDGTYEFSQRSAGASLDASRKLVQ-GQTDIAINWSGGLHHAKR 161
Query: 127 GKALGAPTLGFCIFNNSAMAALTSKEETGKALVIDFDAHHGNGTQEIFWDDADVVHIDLH 186
G+A G FC N+ +A L + L ID D HHG+G Q+ F++ V+ + H
Sbjct: 162 GEASG-----FCYVNDIVLAILNMLRFFPRVLYIDIDIHHGDGVQQAFYESDRVLTVSFH 216
Query: 187 E--RDIYPGSGDVGEIGGINAKGSKINLPMPHYSEDGDYIYAWEEVVIPIVEEVKPKVVI 244
+ D +P +G+ E G K +N+P+ D Y ++ ++ P + +P ++
Sbjct: 217 KYNGDFFPATGNFDENGVKGGKYFALNVPLEDGIGDEQYTSLFKSIIEPTINTFQPSAIV 276
Query: 245 VSAGFDGFKGDGLTTLKLTEVFYSYAGATLRKY--PLAVILEGGYS 288
+ G D D L L+ + R + P+ V+ GGY+
Sbjct: 277 LQCGADSLGYDRLGVFNLSIHAHGECVRFTRSFNIPMLVVGGGGYT 322
>sp|P56520|HDA3_CHICK HISTONE DEACETYLASE 3 (HD3) >gi|2791688|gb|AAB96925.1| (AF039753)
histone deacetylase-3; HD-3 [Gallus gallus]
Length = 428
Score = 85.0 bits (207), Expect = 1e-15
Identities = 71/284 (25%), Positives = 127/284 (44%), Gaps = 21/284 (7%)
Query: 20 HPENPGRLWLVLTAIRELGLENH--VLEPSPIGEELIYRIHEREYVEKIRELSRRG-GGY 76
HP P RL L + + GL V +P + + R H +Y++ ++ +S G+
Sbjct: 22 HPMKPHRLALTHSLVLHYGLYKKMIVFKPYQASQHDMCRFHSEDYIDFLQRVSPNNMQGF 81
Query: 77 LDA--------DTYVSPRTWEAAILALGASRLATLSALRYGGMNLALVRPPGHHAGRRGK 128
+ D V P +E GAS L + L ++A+ G H ++ +
Sbjct: 82 TKSLNAFNVGDDCPVFPGLFEFCSRYTGAS-LQGATQLNNKICDIAINWAGGLHHAKKFE 140
Query: 129 ALGAPTLGFCIFNNSAMAALTSKEETGKALVIDFDAHHGNGTQEIFWDDADVVHIDLHER 188
A G FC N+ + L + + L ID D HHG+G QE F+ V+ + H+
Sbjct: 141 ASG-----FCYVNDIVIGILELLKYHPRVLYIDIDIHHGDGVQEAFYLTDRVMTVSFHKY 195
Query: 189 DIY--PGSGDVGEIGGINAKGSKINLPMPHYSEDGDYIYAWEEVVIPIVEEVKPKVVIVS 246
Y PG+GD+ E+G + + +N+P+ +D Y + ++ V+ +V+ +P +++
Sbjct: 196 GNYFFPGTGDMYEVGAESGRYYALNVPLRDGIDDQSYKHLFQPVINQVVDYYQPTCIVLQ 255
Query: 247 AGFDGFKGDGLTTLKLTEVFYSYAGATLRKY--PLAVILEGGYS 288
G D D L L+ + ++ + PL V+ GGY+
Sbjct: 256 CGADSLGRDRLGCFNLSIRGHGECVEYVKSFNIPLLVLGGGGYT 299
>pir||D70388 acetoin utilization protein - Aquifex aeolicus
>gi|2983524|gb|AAC07100.1| (AE000719) acetoin
utilization protein [Aquifex aeolicus]
Length = 375
Score = 85.0 bits (207), Expect = 1e-15
Identities = 82/308 (26%), Positives = 137/308 (43%), Gaps = 37/308 (12%)
Query: 1 MIGEIYYSRKFLLHKPDNYHPENPGRLWLVLTAIRELGL--ENHVLEPSPIGEELIYRIH 58
+IG + Y + ++ HP R+ L+L + + L E +++ P +E + H
Sbjct: 6 LIGTLDYGK----YRYPKNHPLKIPRVSLLLRFLDAMNLIDEKELIKSRPATKEELLLFH 61
Query: 59 EREYVEKIRELSR-----RG-------GGYLDADTYVSPRTWEAAILALGASRLATLSAL 106
+Y+ + E R +G GGY + VS + + LA G++ A L
Sbjct: 62 TEDYINTLMEAERCQCVPKGAREKYNIGGY---ENPVSYAMFTGSSLATGSTVQAIEEFL 118
Query: 107 RYGGMNLALVRPPGHHAGRRGKALGAPTLGFCIFNNSAMAA-LTSKEETGKALVIDFDAH 165
+ N+A G H + +A G FC N+ A+ K+ + L ID DAH
Sbjct: 119 KG---NVAFNPAGGMHHAFKSRANG-----FCYINDPAVGIEYLRKKGFKRILYIDLDAH 170
Query: 166 HGNGTQEIFWDDADVVHIDLHERDIYP---GSGDVGEIGGINAKGSKINLPMPHYSEDGD 222
H +G QE F+D V + LH+ Y G + EIG KG +N+P+P D +
Sbjct: 171 HCDGVQEAFYDTDQVFVLSLHQSPEYAFPFEKGFLEEIGEGKGKGYNLNIPLPKGLNDNE 230
Query: 223 YIYAWEEVVIPIVEEVKPKVVIVSAGFDGFKGDGLTTLKLTEVFYSYAGATLRKYPLAVI 282
+++A E+ + + E +P+V ++ G D D L+ L+ V + A +R+ V
Sbjct: 231 FLFALEKSLEIVKEVFEPEVYLLQLGTDPLLEDYLSKFNLSNVAFLKAFNIVRE----VF 286
Query: 283 LEGGYSSG 290
EG Y G
Sbjct: 287 GEGVYLGG 294
>pdb|1C3P|A Chain A, Crystal Structure Of An Hdac Homolog From Aquifex Aeolicus
Length = 375
Score = 85.0 bits (207), Expect = 1e-15
Identities = 83/308 (26%), Positives = 136/308 (43%), Gaps = 37/308 (12%)
Query: 1 MIGEIYYSRKFLLHKPDNYHPENPGRLWLVLTAIRELGL--ENHVLEPSPIGEELIYRIH 58
+IG + Y + ++ HP R+ L+L + L E +++ P +E + H
Sbjct: 6 LIGTLDYGK----YRYPKNHPLKIPRVSLLLRFKDAMNLIDEKELIKSRPATKEELLLFH 61
Query: 59 EREYVEKIRELSR-----RG-------GGYLDADTYVSPRTWEAAILALGASRLATLSAL 106
+Y+ + E R +G GGY + VS + + LA G++ A L
Sbjct: 62 TEDYINTLMEAERCQCVPKGAREKYNIGGY---ENPVSYAMFTGSSLATGSTVQAIEEFL 118
Query: 107 RYGGMNLALVRPPGHHAGRRGKALGAPTLGFCIFNNSAMAA-LTSKEETGKALVIDFDAH 165
+ N+A G H + +A G FC NN A+ K+ + L ID DAH
Sbjct: 119 KG---NVAFNPAGGMHHAFKSRANG-----FCYINNPAVGIEYLRKKGFKRILYIDLDAH 170
Query: 166 HGNGTQEIFWDDADVVHIDLHERDIYP---GSGDVGEIGGINAKGSKINLPMPHYSEDGD 222
H +G QE F+D V + LH+ Y G + EIG KG +N+P+P D +
Sbjct: 171 HCDGVQEAFYDTDQVFVLSLHQSPEYAFPFEKGFLEEIGEGKGKGYNLNIPLPKGLNDNE 230
Query: 223 YIYAWEEVVIPIVEEVKPKVVIVSAGFDGFKGDGLTTLKLTEVFYSYAGATLRKYPLAVI 282
+++A E+ + + E +P+V ++ G D D L+ L+ V + A +R+ V
Sbjct: 231 FLFALEKSLEIVKEVFEPEVYLLQLGTDPLLEDYLSKFNLSNVAFLKAFNIVRE----VF 286
Query: 283 LEGGYSSG 290
EG Y G
Sbjct: 287 GEGVYLGG 294
>pdb|1C3R|A Chain A, Crystal Structure Of An Hdac Homolog Complexed With
Trichostatin A >gi|6137504|pdb|1C3R|B Chain B, Crystal
Structure Of An Hdac Homolog Complexed With Trichostatin
A >gi|6137505|pdb|1C3S|A Chain A, Crystal Structure Of
An Hdac Homolog Complexed With Saha
Length = 375
Score = 85.0 bits (207), Expect = 1e-15
Identities = 82/308 (26%), Positives = 134/308 (42%), Gaps = 37/308 (12%)
Query: 1 MIGEIYYSRKFLLHKPDNYHPENPGRLWLVLTAIRELGL--ENHVLEPSPIGEELIYRIH 58
+IG + Y + ++ HP R+ L+L + L E +++ P +E + H
Sbjct: 6 LIGTLDYGK----YRYPKNHPLKIPRVSLLLRFKDAMNLIDEKELIKSRPATKEELLLFH 61
Query: 59 EREYVEKIRELSRRG------------GGYLDADTYVSPRTWEAAILALGASRLATLSAL 106
+Y+ + E R GGY + VS + + LA G++ A L
Sbjct: 62 TEDYINTLMEAERSQSVPKGAREKYNIGGY---ENPVSYAMFTGSSLATGSTVQAIEEFL 118
Query: 107 RYGGMNLALVRPPGHHAGRRGKALGAPTLGFCIFNNSAMAA-LTSKEETGKALVIDFDAH 165
+ N+A G H + +A G FC NN A+ K+ + L ID DAH
Sbjct: 119 KG---NVAFNPAGGMHHAFKSRANG-----FCYINNPAVGIEYLRKKGFKRILYIDLDAH 170
Query: 166 HGNGTQEIFWDDADVVHIDLHERDIYP---GSGDVGEIGGINAKGSKINLPMPHYSEDGD 222
H +G QE F+D V + LH+ Y G + EIG KG +N+P+P D +
Sbjct: 171 HCDGVQEAFYDTDQVFVLSLHQSPEYAFPFEKGFLEEIGEGKGKGYNLNIPLPKGLNDNE 230
Query: 223 YIYAWEEVVIPIVEEVKPKVVIVSAGFDGFKGDGLTTLKLTEVFYSYAGATLRKYPLAVI 282
+++A E+ + + E +P+V ++ G D D L+ L+ V + A +R+ V
Sbjct: 231 FLFALEKSLEIVKEVFEPEVYLLQLGTDPLLEDYLSKFNLSNVAFLKAFNIVRE----VF 286
Query: 283 LEGGYSSG 290
EG Y G
Sbjct: 287 GEGVYLGG 294
>gb|AAF28798.1|AF098295_1 (AF098295) histone deacetylase 3 [Mus musculus]
Length = 428
Score = 85.0 bits (207), Expect = 1e-15
Identities = 74/284 (26%), Positives = 129/284 (45%), Gaps = 21/284 (7%)
Query: 20 HPENPGRLWLVLTAIRELGLENH--VLEPSPIGEELIYRIHEREYVEKIRELSRRG-GGY 76
HP P RL L + + GL V +P + + R H +Y++ ++ +S G+
Sbjct: 22 HPMKPHRLALTHSLVLHYGLYKKMIVFKPYQASQHDMCRFHSEDYIDFLQRVSPTNMQGF 81
Query: 77 ---LDA-----DTYVSPRTWEAAILALGASRLATLSALRYGGMNLALVRPPGHHAGRRGK 128
LDA D V P +E GAS L + L ++A+ G H ++ +
Sbjct: 82 TKSLDAFNVGDDCPVFPGLFEFCSRYTGAS-LQGATQLNNKICDIAINWARGLHHAKKFE 140
Query: 129 ALGAPTLGFCIFNNSAMAALTSKEETGKALVIDFDAHHGNGTQEIFWDDADVVHIDLHER 188
A G FC N+ + L + + L ID D HHG+G QE F+ V+ + H+
Sbjct: 141 ASG-----FCYVNDIVIGILELLKYHPRVLYIDIDIHHGDGVQEAFYLTDRVMTVSFHKY 195
Query: 189 DIY--PGSGDVGEIGGINAKGSKINLPMPHYSEDGDYIYAWEEVVIPIVEEVKPKVVIVS 246
Y PG+GD+ E+G + + +N+P+ +D Y + ++ V+ +V+ +P +++
Sbjct: 196 GNYFFPGAGDMYEVGAESGRYYCLNVPLRDGIDDQSYKHLFQPVISQVVDFYQPTCIVLQ 255
Query: 247 AGFDGFKGDGLTTLKLTEVFYSYAGATLRKY--PLAVILEGGYS 288
G D D L L+ + ++ + PL V+ GGY+
Sbjct: 256 CGADSLGCDRLGCFNLSIRGHGECVEYVKSFNIPLLVLGGGGYT 299
>gb|AAG28475.1|AF195548_1 (AF195548) putative histone deacetylase [Arabidopsis thaliana]
Length = 471
Score = 84.7 bits (206), Expect = 1e-15
Identities = 71/299 (23%), Positives = 126/299 (41%), Gaps = 29/299 (9%)
Query: 2 IGEIYYSRKFLLHKPDNYHPENPGRLWLVLTAIRELGLENH--VLEPSPIGEELIYRIHE 59
IG+ YY + HP P R+ + + I L + PS I R H
Sbjct: 29 IGDYYYGQG---------HPMKPHRIRMAHSLIIHYHLHRRLEISRPSLADASDIGRFHS 79
Query: 60 REYVEKIRELSRRGGGYLDA-----------DTYVSPRTWEAAILALGASRLATLSALRY 108
EYV+ + +S G A D V ++ + G S A + R
Sbjct: 80 PEYVDFLASVSPESMGDPSAARNLRRFNVGEDCPVFDGLFDFCRASAGGSIGAAVKLNRQ 139
Query: 109 GGMNLALVRPPGHHAGRRGKALGAPTLGFCIFNNSAMAALTSKEETGKALVIDFDAHHGN 168
++A+ G H ++ +A G FC N+ + L + + L ID D HHG+
Sbjct: 140 DA-DIAINWGGGLHHAKKSEASG-----FCYVNDIVLGILELLKMFKRVLYIDIDVHHGD 193
Query: 169 GTQEIFWDDADVVHIDLHE-RDIYPGSGDVGEIGGINAKGSKINLPMPHYSEDGDYIYAW 227
G +E F+ V+ + H+ D +PG+G + ++G K +N+P+ +D + +
Sbjct: 194 GVEEAFYTTDRVMTVSFHKFGDFFPGTGHIRDVGAEKGKYYALNVPLNDGMDDESFRSLF 253
Query: 228 EEVVIPIVEEVKPKVVIVSAGFDGFKGDGLTTLKLTEVFYSYAGATLRKYPLAVILEGG 286
++ ++E +P+ V++ G D GD L L+ ++ LR Y + +++ GG
Sbjct: 254 RPLIQKVMEVYQPEAVVLQCGADSLSGDRLGCFNLSVKGHADCLRFLRSYNVPLMVLGG 312
>sp|Q91695|HD11_XENLA PROBABLE HISTONE DEACETYLASE 1-1 (HD1) (MATERNALLY-EXPRESSED
HISTONE DEACETYLASE) (HDM) (AB21)
>gi|2120022|pir||S60381 RPD3 protein homolog - African
clawed frog >gi|602098|emb|CAA55211.1| (X78454) yeast
RPD3 homologue [Xenopus laevis]
Length = 480
Score = 83.9 bits (204), Expect = 3e-15
Identities = 68/297 (22%), Positives = 131/297 (43%), Gaps = 27/297 (9%)
Query: 2 IGEIYYSRKFLLHKPDNYHPENPGRLWLVLTAIRELGL--ENHVLEPSPIGEELIYRIHE 59
+G YY + HP P R+ + + GL + + P E + + H
Sbjct: 19 VGNYYYGQG---------HPMKPHRIRMTHNLLLNYGLYRKMEIFRPHKASAEDMTKYHS 69
Query: 60 REYVEKIR--------ELSRRGGGY-LDADTYVSPRTWEAAILALGASRLATLSALRYGG 110
+Y++ +R E S++ + + D V +E L+ G S +A+ L
Sbjct: 70 DDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSAGGS-VASAVKLNKQQ 128
Query: 111 MNLALVRPPGHHAGRRGKALGAPTLGFCIFNNSAMAALTSKEETGKALVIDFDAHHGNGT 170
++++ G H ++ +A G FC N+ +A L + + + ID D HHG+G
Sbjct: 129 TDISVNWSGGLHHAKKSEASG-----FCYVNDIVLAILELLKYHQRVVYIDIDIHHGDGV 183
Query: 171 QEIFWDDADVVHIDLHER-DIYPGSGDVGEIGGINAKGSKINLPMPHYSEDGDYIYAWEE 229
+E F+ V+ + H+ + +PG+GD+ +IG K +N + +D Y ++
Sbjct: 184 EEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYALRDGIDDESYEAIFKP 243
Query: 230 VVIPIVEEVKPKVVIVSAGFDGFKGDGLTTLKLTEVFYSYAGATLRKYPLAVILEGG 286
V+ ++E +P V++ G D GD L LT ++ ++ + L +++ GG
Sbjct: 244 VMSKVMEMFQPSAVVLQCGADSLSGDRLGCFNLTIKGHAKCVEFIKTFNLPLLMLGG 300
>gb|AAF36425.1|AF125536_1 (AF125536) histone deacetylase-3 [Mus musculus]
Length = 428
Score = 83.9 bits (204), Expect = 3e-15
Identities = 71/284 (25%), Positives = 127/284 (44%), Gaps = 21/284 (7%)
Query: 20 HPENPGRLWLVLTAIRELGLENH--VLEPSPIGEELIYRIHEREYVEKIRELSRRG-GGY 76
HP P RL L + + GL V +P + + R H +Y++ ++ +S G+
Sbjct: 22 HPMKPHRLALTHSLVLHYGLYKKMIVFKPYQASQHDMCRFHSEDYIDFLQRVSPTNMQGF 81
Query: 77 LDA--------DTYVSPRTWEAAILALGASRLATLSALRYGGMNLALVRPPGHHAGRRGK 128
+ D V P +E GAS L + L ++A+ G H ++ +
Sbjct: 82 TKSLNAFNVGDDCPVFPGLFEFCSRYTGAS-LQGATQLNNKICDIAINWAGGLHHAKKFE 140
Query: 129 ALGAPTLGFCIFNNSAMAALTSKEETGKALVIDFDAHHGNGTQEIFWDDADVVHIDLHER 188
A G FC N+ + L + + L ID D HHG+G QE F+ V+ + H+
Sbjct: 141 ASG-----FCYVNDIVIGILEPLKYHPRVLYIDIDIHHGDGVQEAFYLTDRVMTVSFHKY 195
Query: 189 DIY--PGSGDVGEIGGINAKGSKINLPMPHYSEDGDYIYAWEEVVIPIVEEVKPKVVIVS 246
Y PG+GD+ E+G + + +N+P+ +D Y + ++ V+ +V+ +P +++
Sbjct: 196 GNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYKHLFQPVISQVVDFYQPTCIVLQ 255
Query: 247 AGFDGFKGDGLTTLKLTEVFYSYAGATLRKY--PLAVILEGGYS 288
G D D L L+ + ++ + PL V+ GGY+
Sbjct: 256 CGADSLGCDRLGCFNLSIRGHGECVEYVKSFNIPLLVLGGGGYT 299
>gb|AAC23917.1| (AF026949) putative histone deacetylase HDAC1 [Drosophila
melanogaster]
Length = 522
Score = 83.5 bits (203), Expect = 3e-15
Identities = 68/299 (22%), Positives = 122/299 (40%), Gaps = 29/299 (9%)
Query: 2 IGEIYYSRKFLLHKPDNYHPENPGRLWLVLTAIRELGL--ENHVLEPSPIGEELIYRIHE 59
IG YY + HP P R+ + + GL + + P + + + H
Sbjct: 17 IGNYYYGQG---------HPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATADEMTKFHS 67
Query: 60 REYVEKIRELSRRGGGYLDADTY---------VSPRTWEAAILALGASRLATLSALRYGG 110
EYV +R + + V ++ L+ G S A + L
Sbjct: 68 DEYVRFLRSIRPDNMSEYNKQMQRFNVGENCPVFDGLYDFCQLSAGGSVAAAVK-LNKQA 126
Query: 111 MNLALVRPPGHHAGRRGKALGAPTLGFCIFNNSAMAALTSKEETGKALVIDFDAHHGNGT 170
+ + G H ++ +A G FC N+ + L + + L ID D HHG+G
Sbjct: 127 SEICINWGGGLHHAKKSEASG-----FCYVNDIVLGILELLKYHQRVLYIDIDVHHGDGV 181
Query: 171 QEIFWDDADVVHIDLHER-DIYPGSGDVGEIGGINAKGSKINLPMPHYSEDGDYIYAWEE 229
+E F+ V+ + H+ + +PG+GD+ +IG K +N+P+ +D Y +
Sbjct: 182 EEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNIPLRDGMDDDAYESIFVP 241
Query: 230 VVIPIVEEVKPKVVIVSAGFDGFKGDGLTTLKLTEVFYSYAGATLRKY--PLAVILEGG 286
++ ++E +P V++ G D GD L LT + ++KY P +++ GG
Sbjct: 242 IISKVMETFQPAAVVLQCGADSLTGDRLGCFNLTVKGHGKCVEFVKKYNLPFLMVVGGG 300
>pir||JC7102 histone deacetylase (EC 3.5.1.-) - mouse >gi|3639054|gb|AAC36305.1|
(AF074881) histone deacetylase 3 [Mus musculus]
>gi|3676558|gb|AAC67258.1| (AF079310) histone
deacetylase 3 [Mus musculus]
Length = 424
Score = 83.5 bits (203), Expect = 3e-15
Identities = 71/284 (25%), Positives = 127/284 (44%), Gaps = 21/284 (7%)
Query: 20 HPENPGRLWLVLTAIRELGLENH--VLEPSPIGEELIYRIHEREYVEKIRELSRRG-GGY 76
HP P RL L + + GL V +P + + R H +Y++ ++ +S G+
Sbjct: 22 HPMKPHRLALTHSLVLHYGLYKKMIVFKPYQASQHDMCRFHSEDYIDFLQRVSPTNMQGF 81
Query: 77 LDA--------DTYVSPRTWEAAILALGASRLATLSALRYGGMNLALVRPPGHHAGRRGK 128
+ D V P +E GAS L + L ++A+ G H ++ +
Sbjct: 82 TKSLNAFNVGDDCPVFPGLFEFCSRYTGAS-LQGATQLNNKICDIAINWAGGLHHAKKFE 140
Query: 129 ALGAPTLGFCIFNNSAMAALTSKEETGKALVIDFDAHHGNGTQEIFWDDADVVHIDLHER 188
A G FC N+ + L + + L ID D HHG+G QE F+ V+ + H+
Sbjct: 141 ASG-----FCYVNDIVIGILELLKYHPRVLYIDIDIHHGDGVQEAFYLTDRVMTVSFHKY 195
Query: 189 DIY--PGSGDVGEIGGINAKGSKINLPMPHYSEDGDYIYAWEEVVIPIVEEVKPKVVIVS 246
Y PG+GD+ E+G + + +N+P+ +D Y + ++ V+ +V+ +P +++
Sbjct: 196 GNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYKHLFQPVISQVVDFYQPTCIVLQ 255
Query: 247 AGFDGFKGDGLTTLKLTEVFYSYAGATLRKY--PLAVILEGGYS 288
G D D L L+ + ++ + PL V+ GGY+
Sbjct: 256 CGADSLGCDRLGCFNLSIRGHGECVEYVKSFNIPLLVLGGGGYT 299
>gb|AAD22407.1|AF091326_1 (AF091326) histone deacetylase [Plasmodium falciparum]
Length = 449
Score = 83.5 bits (203), Expect = 3e-15
Identities = 45/156 (28%), Positives = 79/156 (49%), Gaps = 3/156 (1%)
Query: 136 GFCIFNNSAMAALTSKEETGKALVIDFDAHHGNGTQEIFWDDADVVHIDLHE-RDIYPGS 194
GFC N+ + L + + + ID D HHG+G +E F+ V+ + H+ D +PG+
Sbjct: 147 GFCYINDIVLGILELLKYHARVMYIDIDVHHGDGVEEAFYVTHRVMTVSFHKFGDYFPGT 206
Query: 195 GDVGEIGGINAKGSKINLPMPHYSEDGDYIYAWEEVVIPIVEEVKPKVVIVSAGFDGFKG 254
GD+ ++G + K +N+P+ D ++ ++ V+ V+ +P +I+ G D G
Sbjct: 207 GDITDVGVNHGKYYSVNVPLNDGMTDDAFVDLFKVVIDKCVQTYRPGAIIIQCGADSLTG 266
Query: 255 DGLTTLKLTEVFYSYAGATLRKY--PLAVILEGGYS 288
D L LT ++ +R Y PL V+ GGY+
Sbjct: 267 DRLGRFNLTIKGHARCVEHVRSYNIPLLVLGGGGYT 302
>gi|4504363 histone deacetylase 3 [Homo sapiens] >gi|7444257|pir||JC5834
histone deacetylase (EC 3.5.1.-) 3 - human
>gi|2326173|gb|AAC52038.1| (U66914) histone deacetylase
3 [Homo sapiens]
Length = 428
Score = 83.1 bits (202), Expect = 4e-15
Identities = 71/284 (25%), Positives = 127/284 (44%), Gaps = 21/284 (7%)
Query: 20 HPENPGRLWLVLTAIRELGLENH--VLEPSPIGEELIYRIHEREYVEKIRELSRRG-GGY 76
HP P RL L + + GL V +P + + R H +Y++ ++ +S G+
Sbjct: 22 HPMKPHRLALTHSLVLHYGLYKKMIVFKPYQASQHDMCRFHSEDYIDFLQRVSPTNMQGF 81
Query: 77 LDA--------DTYVSPRTWEAAILALGASRLATLSALRYGGMNLALVRPPGHHAGRRGK 128
+ D V P +E GAS L + L ++A+ G H ++ +
Sbjct: 82 TKSLNAFNVGDDCPVFPGLFEFCSRYTGAS-LQGATQLNNKICDIAINWAGGLHHAKKFE 140
Query: 129 ALGAPTLGFCIFNNSAMAALTSKEETGKALVIDFDAHHGNGTQEIFWDDADVVHIDLHER 188
A G FC N+ + L + + L ID D HHG+G QE F+ V+ + H+
Sbjct: 141 ASG-----FCYVNDIVIGILELLKYHPRVLYIDIDIHHGDGVQEAFYLTDRVMTVSFHKY 195
Query: 189 DIY--PGSGDVGEIGGINAKGSKINLPMPHYSEDGDYIYAWEEVVIPIVEEVKPKVVIVS 246
Y PG+GD+ E+G + + +N+P+ +D Y + ++ V+ +V+ +P +++
Sbjct: 196 GNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYKHLFQPVINQVVDFYQPTCIVLQ 255
Query: 247 AGFDGFKGDGLTTLKLTEVFYSYAGATLRKY--PLAVILEGGYS 288
G D D L L+ + ++ + PL V+ GGY+
Sbjct: 256 CGADSLGCDRLGCFNLSIRGHGECVEYVKSFNIPLLVLGGGGYT 299
>gb|AAB88240.1| (U75696) RPD3-2A [Homo sapiens]
Length = 429
Score = 83.1 bits (202), Expect = 4e-15
Identities = 71/284 (25%), Positives = 127/284 (44%), Gaps = 21/284 (7%)
Query: 20 HPENPGRLWLVLTAIRELGLENH--VLEPSPIGEELIYRIHEREYVEKIRELSRRG-GGY 76
HP P RL L + + GL V +P + + R H +Y++ ++ +S G+
Sbjct: 23 HPMKPHRLALTHSLVLHYGLYKKMIVFKPYQASQHDMCRFHSEDYIDFLQRVSPTNMQGF 82
Query: 77 LDA--------DTYVSPRTWEAAILALGASRLATLSALRYGGMNLALVRPPGHHAGRRGK 128
+ D V P +E GAS L + L ++A+ G H ++ +
Sbjct: 83 TKSLNAFNVGDDCPVFPGLFEFCSRYTGAS-LQGATQLNNKICDIAINWAGGLHHAKKFE 141
Query: 129 ALGAPTLGFCIFNNSAMAALTSKEETGKALVIDFDAHHGNGTQEIFWDDADVVHIDLHER 188
A G FC N+ + L + + L ID D HHG+G QE F+ V+ + H+
Sbjct: 142 ASG-----FCYVNDIVIGILELLKYHPRVLYIDIDIHHGDGVQEAFYLTDRVMTVSFHKY 196
Query: 189 DIY--PGSGDVGEIGGINAKGSKINLPMPHYSEDGDYIYAWEEVVIPIVEEVKPKVVIVS 246
Y PG+GD+ E+G + + +N+P+ +D Y + ++ V+ +V+ +P +++
Sbjct: 197 GNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYKHLFQPVINQVVDFYQPTCIVLQ 256
Query: 247 AGFDGFKGDGLTTLKLTEVFYSYAGATLRKY--PLAVILEGGYS 288
G D D L L+ + ++ + PL V+ GGY+
Sbjct: 257 CGADSLGCDRLGCFNLSIRGHGECVEYVKSFNIPLLVLGGGGYT 300
>gi|11416571 histone deacetylase 3 [Homo sapiens]
>gi|3334210|sp|O15379|HDA3_HUMAN HISTONE DEACETYLASE 3
(HD3) >gi|2661172|gb|AAB88241.1| (U75697) RPD3-2B [Homo
sapiens] >gi|2789656|gb|AAC98927.1| (AF039703) histone
deacetylase 3 [Homo sapiens] >gi|3201676|gb|AAC26509.1|
(AF059650) histone deacetylase 3 [Homo sapiens]
Length = 428
Score = 83.1 bits (202), Expect = 4e-15
Identities = 71/284 (25%), Positives = 127/284 (44%), Gaps = 21/284 (7%)
Query: 20 HPENPGRLWLVLTAIRELGLENH--VLEPSPIGEELIYRIHEREYVEKIRELSRRG-GGY 76
HP P RL L + + GL V +P + + R H +Y++ ++ +S G+
Sbjct: 22 HPMKPHRLALTHSLVLHYGLYKKMIVFKPYQASQHDMCRFHSEDYIDFLQRVSPTNMQGF 81
Query: 77 LDA--------DTYVSPRTWEAAILALGASRLATLSALRYGGMNLALVRPPGHHAGRRGK 128
+ D V P +E GAS L + L ++A+ G H ++ +
Sbjct: 82 TKSLNAFNVGDDCPVFPGLFEFCSRYTGAS-LQGATQLNNKICDIAINWAGGLHHAKKFE 140
Query: 129 ALGAPTLGFCIFNNSAMAALTSKEETGKALVIDFDAHHGNGTQEIFWDDADVVHIDLHER 188
A G FC N+ + L + + L ID D HHG+G QE F+ V+ + H+
Sbjct: 141 ASG-----FCYVNDIVIGILELLKYHPRVLYIDIDIHHGDGVQEAFYLTDRVMTVSFHKY 195
Query: 189 DIY--PGSGDVGEIGGINAKGSKINLPMPHYSEDGDYIYAWEEVVIPIVEEVKPKVVIVS 246
Y PG+GD+ E+G + + +N+P+ +D Y + ++ V+ +V+ +P +++
Sbjct: 196 GNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYKHLFQPVINQVVDFYQPTCIVLQ 255
Query: 247 AGFDGFKGDGLTTLKLTEVFYSYAGATLRKY--PLAVILEGGYS 288
G D D L L+ + ++ + PL V+ GGY+
Sbjct: 256 CGADSLGCDRLGCFNLSIRGHGECVEYVKSFNIPLLVLGGGGYT 299
>gb|AAF52023.1| (AE003602) HDAC3 gene product [Drosophila melanogaster]
Length = 438
Score = 82.7 bits (201), Expect = 6e-15
Identities = 67/288 (23%), Positives = 123/288 (42%), Gaps = 25/288 (8%)
Query: 20 HPENPGRLWLVLTAIRELGLENH--VLEPSPIGEELIYRIHEREYVEKIRELSRRG---- 73
HP P RL + + + GL + P + + R H EY+ +++++ +
Sbjct: 23 HPMKPQRLAVTHSLVMNYGLHKKMKIYRPYKASAQDMLRFHSDEYIAYLQQVTPQNIQCN 82
Query: 74 ----GGYL-----DADTYVSPRTWEAAILALGASRLATLSALRYGGMNLALVRPPGHHAG 124
YL D V ++ + GAS L L + ++ + G H
Sbjct: 83 SVAYTKYLAHFSVGEDCPVFDGLFDFCAMYTGAS-LEGAQKLNHNHSDICINWSGGLHHA 141
Query: 125 RRGKALGAPTLGFCIFNNSAMAALTSKEETGKALVIDFDAHHGNGTQEIFWDDADVVHID 184
++ +A G FC N+ + L + + L ID D HHG+G QE F+ V+
Sbjct: 142 KKFEASG-----FCYVNDIVIGILELLKYHPRVLYIDIDVHHGDGVQEAFYLTDRVMTAS 196
Query: 185 LHERDIY--PGSGDVGEIGGINAKGSKINLPMPHYSEDGDYIYAWEEVVIPIVEEVKPKV 242
H+ Y PG+GD+ EIG + + +N+P+ +D Y ++ ++ I++ +P
Sbjct: 197 FHKYGNYFFPGTGDMYEIGAESGRYYSVNVPLKEGIDDQSYFQVFKPIISAIMDFYRPTA 256
Query: 243 VIVSAGFDGFKGDGLTTLKLTEVFYSYAGATLRK--YPLAVILEGGYS 288
+++ G D GD L L+ + +++ P V+ GGY+
Sbjct: 257 IVLQCGADSLAGDRLGCFSLSTKGHGECVKFVKELNVPTLVVGGGGYT 304
>gb|AAC83649.1| (AF071559) histone deacetylase dHDAC3 [Drosophila melanogaster]
Length = 438
Score = 80.8 bits (196), Expect = 2e-14
Identities = 66/288 (22%), Positives = 123/288 (41%), Gaps = 25/288 (8%)
Query: 20 HPENPGRLWLVLTAIRELGLENH--VLEPSPIGEELIYRIHEREYVEKIRELSRRG---- 73
HP P RL + + + GL + P + + R H EY+ +++++ +
Sbjct: 23 HPMKPQRLAVTHSLVMNYGLHKKMKIYRPYKASAQDMLRFHSDEYIAYLQQVTPQNIQCN 82
Query: 74 ----GGYL-----DADTYVSPRTWEAAILALGASRLATLSALRYGGMNLALVRPPGHHAG 124
YL D V ++ + GAS L L + ++ + G H
Sbjct: 83 SVAYTKYLAHFSVGEDCPVFDGLFDFCAMYTGAS-LEGAQKLNHNHSDICINWSGGLHHA 141
Query: 125 RRGKALGAPTLGFCIFNNSAMAALTSKEETGKALVIDFDAHHGNGTQEIFWDDADVVHID 184
++ +A G FC ++ + L + + L ID D HHG+G QE F+ V+
Sbjct: 142 KKFEASG-----FCYVDDIVIGILELLKYHPRVLYIDIDVHHGDGVQEAFYLTDRVMTAS 196
Query: 185 LHERDIY--PGSGDVGEIGGINAKGSKINLPMPHYSEDGDYIYAWEEVVIPIVEEVKPKV 242
H+ Y PG+GD+ EIG + + +N+P+ +D Y ++ ++ I++ +P
Sbjct: 197 FHKYGNYFFPGTGDMYEIGAESGRYYSVNVPLKEGIDDQSYFQVFKPIISAIMDFYRPTA 256
Query: 243 VIVSAGFDGFKGDGLTTLKLTEVFYSYAGATLRK--YPLAVILEGGYS 288
+++ G D GD L L+ + +++ P V+ GGY+
Sbjct: 257 IVLQCGADSLAGDRLGCFSLSTKGHGECVKFVKELNVPTLVVGGGGYT 304
>gb|AAG21919.1|AF139991_1 (AF139991) histone deacetylase [Cryptosporidium parvum]
Length = 444
Score = 80.4 bits (195), Expect = 3e-14
Identities = 61/285 (21%), Positives = 121/285 (42%), Gaps = 22/285 (7%)
Query: 20 HPENPGRLWLVLTAIRELGLENH--VLEPSPIGEELIYRIHEREYVEKIRELS------- 70
HP P R+ + I L H + +P + + HE +Y+ + ++
Sbjct: 22 HPMKPQRIRMAHNLILSYDLYKHMEIYKPHKSPQSELVYFHEEDYINFLSSINPDNSKDF 81
Query: 71 ----RRGGGYLDADTYVSPRTWEAAILALGASRLATLSALRYGGMNLALVRPPGHHAGRR 126
+R D V +E + G S + L ++ + G H +R
Sbjct: 82 GLQLKRFNLGETTDCPVFDGLFEFQQICAGGS-IDGAYKLNNEQSDICINWSGGLHHAKR 140
Query: 127 GKALGAPTLGFCIFNNSAMAALTSKEETGKALVIDFDAHHGNGTQEIFWDDADVVHIDLH 186
+A G FC N+ + L + + + ID D HHG+G +E F+ V+ + H
Sbjct: 141 SEASG-----FCYINDIVLGILELLKYHARVMYIDIDVHHGDGVEEAFYLSHRVLTVSFH 195
Query: 187 E-RDIYPGSGDVGEIGGINAKGSKINLPMPHYSEDGDYIYAWEEVVIPIVEEVKPKVVIV 245
+ + +PG+GD+ +IG K +N+P+ +D ++ ++ ++ +E +P +++
Sbjct: 196 KFGEFFPGTGDITDIGVAQGKYYSVNVPLNDGIDDDSFLSLFKPIISKCIEVYRPGAIVL 255
Query: 246 SAGFDGFKGDGLTTLKLTEVFYSYAGATLRKY--PLAVILEGGYS 288
G D +GD L L+ ++ + + PL ++ GGY+
Sbjct: 256 QCGADSVRGDRLGRFNLSIKGHAECVEFCKIFNIPLLILGGGGYT 300
>gb|AAF80489.1|AF163862_1 (AF163862) histone deacetylase Rpd3A [Aspergillus nidulans]
Length = 687
Score = 78.4 bits (190), Expect = 1e-13
Identities = 59/279 (21%), Positives = 122/279 (43%), Gaps = 18/279 (6%)
Query: 20 HPENPGRLWLVLTAIRELGL--ENHVLEPSPIGEELIYRIHEREYVEKIRELS------- 70
HP P R+ + + + L + + P + + + H EY++ + +++
Sbjct: 45 HPMKPHRIRMTHSLVMNYSLYKKMEIYRAKPASKFEMTQFHTDEYIDFLSKVTPDNMDAF 104
Query: 71 --RRGGGYLDADTYVSPRTWEAAILALGASRLATLSALRYGGMNLALVRPPGHHAGRRGK 128
+ + D V +E ++ G S + + L ++A+ G H ++ +
Sbjct: 105 AKEQSKYNVGDDCPVFDGLFEFCGISAGGS-MEGAARLNRNKCDIAVNWAGGLHHAKKSE 163
Query: 129 ALGAPTLGFCIFNNSAMAALTSKEETGKALVIDFDAHHGNGTQEIFWDDADVVHIDLHER 188
A G FC N+ + L + L +D D HHG+G +E F+ V+ + H+
Sbjct: 164 ASG-----FCYVNDIVLGILELLRFKQRVLYVDIDVHHGDGVEEAFYTTDRVMTVSFHKY 218
Query: 189 -DIYPGSGDVGEIGGINAKGSKINLPMPHYSEDGDYIYAWEEVVIPIVEEVKPKVVIVSA 247
+ +PG+G++ +IG K +N P+ +D Y +E V+ ++E +P+ V++
Sbjct: 219 GEYFPGTGELRDIGVGQGKYYAVNFPLRDGIDDVSYKSIFEPVIKSVMEWYRPEAVVLQC 278
Query: 248 GFDGFKGDGLTTLKLTEVFYSYAGATLRKYPLAVILEGG 286
G D GD L L+ ++ ++ + L ++ GG
Sbjct: 279 GGDSLSGDRLGCFNLSMRGHANCVKYVKSFNLPTLIVGG 317
>sp|Q09440|HDA2_CAEEL PUTATIVE HISTONE DEACETYLASE C08B11.2 >gi|7495642|pir||T19067
hypothetical protein C08B11.2 - Caenorhabditis elegans
>gi|3874170|emb|CAA86662.1| (Z46676) contains similarity
to Pfam domain: PF00850 (Histone deacetylase family),
Score=571.5, E-value=1.7e-168, N=1~cDNA EST yk627d3.5
comes from this gene [Caenorhabditis elegans]
Length = 507
Score = 76.9 bits (186), Expect = 3e-13
Identities = 77/303 (25%), Positives = 125/303 (40%), Gaps = 30/303 (9%)
Query: 6 YYSRKFLLH-KPDNYHPENPGRLWLV--LTAIRELGLENHVLEPSPIGEELIYRIHEREY 62
YY K + H HP P RL + L E+ V+E + I H +Y
Sbjct: 33 YYYHKDVGHFHYGQLHPMKPQRLVVCNDLVVSYEMPKYMTVVESPKLDAADISVFHTEDY 92
Query: 63 VEKIRELSRRGGGYLDADTY----------VSPRTWEAAILALGASRLATLSALRYGGMN 112
V ++ ++ + G + D + W+ L G S + L + +
Sbjct: 93 VNFLQTVTPKLGLTMPDDVLRQFNIGEDCPIFAGLWDYCTLYAGGS-VEGARRLNHKMND 151
Query: 113 LALVRPPGHHAGRRGKALGAPTLGFCIFNNSAMAALTSKEETGKALVIDFDAHHGNGTQE 172
+ + P G H ++ +A G FC N+ + L + + L ID D HHG+G QE
Sbjct: 152 IVINWPGGLHHAKKSEASG-----FCYVNDIVLGILELLKYHKRVLYIDIDIHHGDGVQE 206
Query: 173 IFWDDADVVHIDLHE-RDIYPGSGDVGEIGGINAKGSKINLPMPHYSEDGDYIYAWEEVV 231
F + V+ + H +PGSG + + G K IN+P+ D Y+ +E V+
Sbjct: 207 AFNNSDRVMTVSFHRFGQYFPGSGSIMDKGVGPGKYFAINVPLMAAIRDEPYLKLFESVI 266
Query: 232 IPIVEEVKPKVVIVSAGFDGFKGDGLTTLKLTEVFYSYAGATLRKY------PLAVILEG 285
+ E P+ +++ G D D L L+ F ++A A KY PL V+ G
Sbjct: 267 SGVEENFNPEAIVLQCGSDSLCEDRLGQFALS--FNAHARAV--KYVKSLGKPLMVLGGG 322
Query: 286 GYS 288
GY+
Sbjct: 323 GYT 325
>pir||T47443 hypothetical protein T18B22.80 - Arabidopsis thaliana
>gi|6967116|emb|CAB72470.1| (AL138652) putative protein
[Arabidopsis thaliana]
Length = 419
Score = 75.3 bits (182), Expect = 1e-12
Identities = 71/280 (25%), Positives = 116/280 (41%), Gaps = 23/280 (8%)
Query: 20 HPENPGRLWLVLTAIRELGLEN--HVLEPSPIGEELIYRIHEREYVEKIRELSRRGGGY- 76
HP P RL + I GL + V P + + H +YVE ++ ++
Sbjct: 21 HPMKPHRLCMTHHLILAYGLHSKMEVYRPHKAYPIEMAQFHSPDYVEFLQRINPENQNLF 80
Query: 77 --------LDADTYVSPRTWEAAILALGASRLATLSALRYGGMNLALVRPPGHHAGRRGK 128
L D V +E L G T+ A R +N L + AG
Sbjct: 81 PNEMARYNLGEDCPVFEDLFEFCQLYAGG----TIDAARR--LNNKLCDIAINWAGGLHH 134
Query: 129 ALGAPTLGFCIFNNSAMAALTSKEETGKALVIDFDAHHGNGTQEIFWDDADVVHIDLHE- 187
A GFC N+ + L + + L ID D HHG+G +E F+ V+ + H+
Sbjct: 135 AKKCDASGFCYINDLVLGILELLKHHPRVLYIDIDVHHGDGVEEAFYFTDRVMTVSFHKF 194
Query: 188 -RDIYPGSGDVGEIGGINAKGSKINLPMPHYSEDGDYIYAWEEVVIPIVEEVKPKVVIVS 246
+PG+GDV EIG K IN+P+ +DG ++ + +VE +P +++
Sbjct: 195 GDKFFPGTGDVKEIGEREGKFYAINVPL----KDGIDDSSFNRLFRTVVEIYQPGAIVLQ 250
Query: 247 AGFDGFKGDGLTTLKLTEVFYSYAGATLRKYPLAVILEGG 286
G D D L L+ ++ ++K+ L +++ GG
Sbjct: 251 CGADSLARDRLGCFNLSIDGHAECVKFVKKFNLPLLVTGG 290
>gb|AAB87752.1| (AF005482) histone deacetylase-3C [Homo sapiens]
Length = 371
Score = 73.7 bits (178), Expect = 3e-12
Identities = 61/246 (24%), Positives = 112/246 (44%), Gaps = 19/246 (7%)
Query: 56 RIHEREYVEKIRELSRRG-GGYLDA--------DTYVSPRTWEAAILALGASRLATLSAL 106
R H +Y++ ++ +S G+ + D V P +E GAS L + L
Sbjct: 3 RFHSEDYIDFLQRVSPTNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRYTGAS-LQGATQL 61
Query: 107 RYGGMNLALVRPPGHHAGRRGKALGAPTLGFCIFNNSAMAALTSKEETGKALVIDFDAHH 166
++A+ G H ++ +A G FC N+ + L + + L ID D HH
Sbjct: 62 NNKICDIAINWAGGLHHAKKFEASG-----FCYVNDIVIGILELLKYHPRVLYIDIDIHH 116
Query: 167 GNGTQEIFWDDADVVHIDLHERDIY--PGSGDVGEIGGINAKGSKINLPMPHYSEDGDYI 224
G+G QE F+ V+ + H+ Y PG+GD+ E+G + + +N+P+ +D Y
Sbjct: 117 GDGVQEAFYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYK 176
Query: 225 YAWEEVVIPIVEEVKPKVVIVSAGFDGFKGDGLTTLKLTEVFYSYAGATLRKY--PLAVI 282
+ ++ V+ +V+ +P +++ G D D L L+ + ++ + PL V+
Sbjct: 177 HLFQPVINQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGECVEYVKSFNIPLLVL 236
Query: 283 LEGGYS 288
GGY+
Sbjct: 237 GGGGYT 242
>gb|AAF80490.1|AF164342_1 (AF164342) histone deacetylase Hos2A [Aspergillus nidulans]
Length = 481
Score = 73.0 bits (176), Expect = 5e-12
Identities = 45/177 (25%), Positives = 79/177 (44%), Gaps = 15/177 (8%)
Query: 121 HHAGRRGKALGAPTLGFCIFNNSAMAALTSKEETGKALVIDFDAHHGNGTQEIFWDDADV 180
HHA + A GFC N+ +A L + + ID D HHG+G ++ FW V
Sbjct: 173 HHAKK------AEASGFCYVNDIVLAILQLLRIHPRVMYIDIDVHHGDGVEQAFWSTDRV 226
Query: 181 VHIDLHERD---IYPGSGDVGEIGGIN----AKGSKINLPMPHYSEDGDYIYAWEEVVIP 233
+ + H+ D +PG+G + G + +N+P+ +D Y+ +++VV
Sbjct: 227 LTVSFHKYDKENFFPGTGPLDSTGPTHPLNPGAHHAVNVPLHDGIDDESYVQLFKDVVGA 286
Query: 234 IVEEVKPKVVIVSAGFDGFKGDGLTTLKLTEVFYSYAGATLRKY--PLAVILEGGYS 288
V + +P +++ G D D L L + A + + P+ V+ GGY+
Sbjct: 287 CVSKFRPAAIVLQCGADSLGCDRLGCFNLNVAAHGACVAYTKTFGLPMLVVGGGGYT 343
>gb|AAC08351.1| (AF053139) histone deacetylase 3 [Homo sapiens]
Length = 259
Score = 72.6 bits (175), Expect = 6e-12
Identities = 43/157 (27%), Positives = 78/157 (49%), Gaps = 4/157 (2%)
Query: 136 GFCIFNNSAMAALTSKEETGKALVIDFDAHHGNGTQEIFWDDADVVHIDLHERDIY--PG 193
GFC N+ + L + + L ID D HHG+G QE F+ V+ + H+ Y PG
Sbjct: 49 GFCYVNDIVIGILELLKYHPRVLYIDIDIHHGDGVQEAFYLTDRVMTVSFHKYGNYFFPG 108
Query: 194 SGDVGEIGGINAKGSKINLPMPHYSEDGDYIYAWEEVVIPIVEEVKPKVVIVSAGFDGFK 253
+GD+ E+G + + +N+P+ +D Y + ++ V+ +V+ +P +++ G D
Sbjct: 109 TGDMYEVGAESGRYYCLNVPLRDGIDDQSYKHLFQPVINQVVDFYQPTCIVLQCGADSLG 168
Query: 254 GDGLTTLKLTEVFYSYAGATLRKY--PLAVILEGGYS 288
D L L+ + ++ + PL V+ GGY+
Sbjct: 169 CDRLGCFNLSIRGHGECVEYVKSFNIPLLVLGGGGYT 205
>sp|P28606|YGLA_SYNP2 HYPOTHETICAL 34.1 KD PROTEIN IN GLNA 3'REGION
>gi|1075598|pir||B47050 glnA 3'-region hypothetical
protein - Synechococcus sp >gi|580726|emb|CAA78367.1|
(Z13965) Portion of hypothetical protein [Synechococcus
PCC7002]
Length = 310
Score = 71.4 bits (172), Expect = 1e-11
Identities = 60/217 (27%), Positives = 92/217 (41%), Gaps = 31/217 (14%)
Query: 88 WEAAIL-----ALGASRLATLSALRYGGMNLALVRPPGHHAGRRGKALGAPTLGFCIFNN 142
W A ++ A+G + L AL +G LA G H G G FCI N+
Sbjct: 94 WSAGVVQRTLTAVGGTILTAQLALEHG---LACNTAGGTHHAFPGYGSG-----FCILND 145
Query: 143 SAMAALTSKEE--TGKALVIDFDAHHGNGTQEIFWDDADVVHIDLHERDIYPGSGDVGEI 200
A+A T ++ + L++D D H G+GT IF DD V +H +P
Sbjct: 146 LAIATRTIQQRGLAQRILIVDLDVHQGDGTAFIFQDDPTVFTFSMHCEVNFPS------- 198
Query: 201 GGINAKGSKINLPMPHYSEDGDYIYAWEEVVIPIVEEVKPKVVIVSAGFDGFKGDGLTTL 260
+ S ++L +P +D Y+ + ++ +VKP +V AG D GD L L
Sbjct: 199 ---QKQRSDLDLGLPEGLDDDGYLQILAHHLEDLLSQVKPDLVFYDAGVDTHVGDRLGKL 255
Query: 261 KLTEV-FYSYAGATLRK-----YPLAVILEGGYSSGL 291
+T Y L YP+A ++ GGY+ +
Sbjct: 256 AMTNTGLYRRERLVLSTCLAAGYPVACVIGGGYAKNI 292
>emb|CAA78368.1| (Z13965) Portion of hypothetical protein [Synechococcus PCC7002]
Length = 300
Score = 71.4 bits (172), Expect = 1e-11
Identities = 60/217 (27%), Positives = 92/217 (41%), Gaps = 31/217 (14%)
Query: 88 WEAAIL-----ALGASRLATLSALRYGGMNLALVRPPGHHAGRRGKALGAPTLGFCIFNN 142
W A ++ A+G + L AL +G LA G H G G FCI N+
Sbjct: 84 WSAGVVQRTLTAVGGTILTAQLALEHG---LACNTAGGTHHAFPGYGSG-----FCILND 135
Query: 143 SAMAALTSKEE--TGKALVIDFDAHHGNGTQEIFWDDADVVHIDLHERDIYPGSGDVGEI 200
A+A T ++ + L++D D H G+GT IF DD V +H +P
Sbjct: 136 LAIATRTIQQRGLAQRILIVDLDVHQGDGTAFIFQDDPTVFTFSMHCEVNFPS------- 188
Query: 201 GGINAKGSKINLPMPHYSEDGDYIYAWEEVVIPIVEEVKPKVVIVSAGFDGFKGDGLTTL 260
+ S ++L +P +D Y+ + ++ +VKP +V AG D GD L L
Sbjct: 189 ---QKQRSDLDLGLPEGLDDDGYLQILAHHLEDLLSQVKPDLVFYDAGVDTHVGDRLGKL 245
Query: 261 KLTEV-FYSYAGATLRK-----YPLAVILEGGYSSGL 291
+T Y L YP+A ++ GGY+ +
Sbjct: 246 AMTNTGLYRRERLVLSTCLAAGYPVACVIGGGYAKNI 282
>emb|CAA78369.1| (Z13965) Portion of hypothetical protein [Synechococcus PCC7002]
Length = 278
Score = 71.4 bits (172), Expect = 1e-11
Identities = 60/217 (27%), Positives = 92/217 (41%), Gaps = 31/217 (14%)
Query: 88 WEAAIL-----ALGASRLATLSALRYGGMNLALVRPPGHHAGRRGKALGAPTLGFCIFNN 142
W A ++ A+G + L AL +G LA G H G G FCI N+
Sbjct: 62 WSAGVVQRTLTAVGGTILTAQLALEHG---LACNTAGGTHHAFPGYGSG-----FCILND 113
Query: 143 SAMAALTSKEE--TGKALVIDFDAHHGNGTQEIFWDDADVVHIDLHERDIYPGSGDVGEI 200
A+A T ++ + L++D D H G+GT IF DD V +H +P
Sbjct: 114 LAIATRTIQQRGLAQRILIVDLDVHQGDGTAFIFQDDPTVFTFSMHCEVNFPS------- 166
Query: 201 GGINAKGSKINLPMPHYSEDGDYIYAWEEVVIPIVEEVKPKVVIVSAGFDGFKGDGLTTL 260
+ S ++L +P +D Y+ + ++ +VKP +V AG D GD L L
Sbjct: 167 ---QKQRSDLDLGLPEGLDDDGYLQILAHHLEDLLSQVKPDLVFYDAGVDTHVGDRLGKL 223
Query: 261 KLTEV-FYSYAGATLRK-----YPLAVILEGGYSSGL 291
+T Y L YP+A ++ GGY+ +
Sbjct: 224 AMTNTGLYRRERLVLSTCLAAGYPVACVIGGGYAKNI 260
>gi|6325325 Similar to Hda1p, Rpd3p, Hos2p, and Hos3p; Hos1p [Saccharomyces
cerevisiae] >gi|2833221|sp|Q12214|HOS1_YEAST HOS1
PROTEIN >gi|1084790|pir||S54089 hypothetical protein
YPR068c - yeast (Saccharomyces cerevisiae)
>gi|805048|emb|CAA89185.1| (Z49219) unknown
[Saccharomyces cerevisiae] >gi|1314136|emb|CAA94976.1|
(Z71255) unknown [Saccharomyces cerevisiae]
Length = 470
Score = 69.5 bits (167), Expect = 5e-11
Identities = 49/183 (26%), Positives = 82/183 (44%), Gaps = 10/183 (5%)
Query: 124 GRRGKALGAPTLGFCIFNNSAMAALT-SKEETGKALVIDFDAHHGNGTQEIFWDDADV-- 180
G R A GFC N+ + K + K +DFD HHG+G ++ F +
Sbjct: 207 GGRHHAFKQRASGFCYINDVVLLIQRLRKAKLNKITYVDFDLHHGDGVEKAFQYSKQIQT 266
Query: 181 VHIDLHERDIYPGSGDVGEIGGINAKGSKINLPMPHYSEDGDYIYAWEEVVIPIVEEVKP 240
+ + L+E +PG+G + + + +N+P+ H +D ++V P++E +P
Sbjct: 267 ISVHLYEPGFFPGTGSLSDS---RKDKNVVNIPLKHGCDDNYLELIASKIVNPLIERHEP 323
Query: 241 KVVIVSAGFDGFKGDGLTTLKLTEVFYSYAGATLRK-YPLAVIL---EGGYSSGLKKGFP 296
+ +I+ G DG GD +LT S + K YP A I GGY+ L F
Sbjct: 324 EALIIECGGDGLLGDRFNEWQLTIRGLSRIIINIMKSYPRAHIFLLGGGGYNDLLMSRFY 383
Query: 297 AFI 299
++
Sbjct: 384 TYL 386
>emb|CAC14522.1| (AL446004) histone deacetylase 2 [Leishmania major]
Length = 428
Score = 68.7 bits (165), Expect = 9e-11
Identities = 54/232 (23%), Positives = 94/232 (40%), Gaps = 9/232 (3%)
Query: 93 LALGASRLATLSALRYGGMNLALVRPPGHHAGRRGKALGAPTLGFCIFNNSAMAALTSKE 152
+A + L L G +++A+ G H + G+ G FC N+ + L +
Sbjct: 125 IATASGTLMGAVLLNSGQVDVAVHWGGGMHHSKCGECSG-----FCYVNDIVLGILELLK 179
Query: 153 ETGKALVIDFDAHHGNGTQEIFWDDADVVHIDLHE--RDIYPGSGDVGEIGGINAKGSKI 210
+ L +D D HHG+G E F V + LH+ +PG+G ++G + +
Sbjct: 180 CHDRVLYVDIDMHHGDGVDEAFCTSDRVFTLSLHKFGESFFPGTGHPRDVGYGRGRYYSM 239
Query: 211 NLPMPHYSEDGDYIYAWEEVVIPIVEEVKPKVVIVSAGFDGFKGDGLTTLKLTEVFYSYA 270
NL + D Y+ +E + IV P +++ G D GD L L L+ +
Sbjct: 240 NLAVWDGITDFYYLGIFEHALHSIVRRYSPDAIVLQCGADSLAGDRLGLLNLSSFGHGQC 299
Query: 271 GATLRKYPLAVILEGGYSSGLKKGFPAFIRGYEEDKVRDHAQPSYETLKLVE 322
+R + ++ GG ++ A + YE + H P L + E
Sbjct: 300 VQAVRDLGIPMLALGGGGYTIRN--VAKLWAYETSILTGHPLPPNTVLPVAE 349
Database: ./suso.pep
Posted date: Jul 6, 2001 5:57 PM
Number of letters in database: 840,471
Number of sequences in database: 2977
Database: /banques/blast2/nr.pep
Posted date: Dec 14, 2000 12:46 PM
Number of letters in database: 188,266,275
Number of sequences in database: 595,510
Lambda K H
0.318 0.140 0.426
Gapped
Lambda K H
0.270 0.0470 0.230
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 142226276
Number of Sequences: 2977
Number of extensions: 6616332
Number of successful extensions: 16229
Number of sequences better than 1.0e-10: 119
Number of HSP's better than 0.0 without gapping: 9
Number of HSP's successfully gapped in prelim test: 110
Number of HSP's that attempted gapping in prelim test: 15873
Number of HSP's gapped (non-prelim): 145
length of query: 334
length of database: 189,106,746
effective HSP length: 52
effective length of query: 282
effective length of database: 157,985,422
effective search space: 44551889004
effective search space used: 44551889004
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 41 (21.7 bits)
S2: 165 (68.7 bits)