BLASTP 2.0.10 [Aug-26-1999]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= PAB0785 (rfbB) DE:dTDP-glucose 4,6-dehydratase (rfbB)
(333 letters)
Database: ./suso.pep; /banques/blast2/nr.pep
598,487 sequences; 189,106,746 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
pir||B75098 dtdp-glucose 4,6-dehydratase (rfbb) PAB0785 - Pyroco... 693 0.0
pir||G71151 probable dTDP-glucose 4,6-dehydratase - Pyrococcus h... 620 e-177
gi|11497937 dTDP-glucose 4,6-dehydratase (rfbB) [Archaeoglobus f... 558 e-158
pir||H69105 dTDP-glucose 4,6-dehydratase - Methanobacterium ther... 386 e-106
pir||E70566 probable DTDP-GLUCOSE 4 - Mycobacterium tuberculosis... 340 1e-92
gb|AAD13546.1| (AF080235) NDP-hexose 4,6-dehydratase homolog [St... 339 4e-92
pir||T00102 dTDPglucose 4,6-dehydratase (EC 4.2.1.46) - Actinoba... 339 4e-92
gb|AAG18457.1|AF306787_1 (AF306787) AprE [Streptomyces tenebrarius] 339 4e-92
gb|AAA68211.1| (L37354) thymidine diphosphoglucose 4,6-dehydrata... 338 7e-92
gb|AAF13998.1|AF201913_1 (AF201913) SgcA [Streptomyces globisporus] 338 7e-92
dbj|BAA94402.1| (AB041266) dTDP-D-glucose 4,6-dehydratase [Actin... 337 9e-92
gb|AAF67513.1|AF170880_20 (AF170880) NovT [Streptomyces spheroides] 335 3e-91
dbj|BAA19633.1| (AB002668) dTDP-D-glucose-4,6-dehydratase [Actin... 335 4e-91
dbj|BAA82532.1| (AB030032) dTDP-D-glucose 4,6-dehydratase [Actin... 334 1e-90
gb|AAC44074.1| (U51197) dTDP-D-glucose-4,6-dehydratase [Sphingom... 333 2e-90
sp|P55294|RFBB_NEIMB DTDP-GLUCOSE 4,6-DEHYDRATASE >gi|7437244|pi... 332 3e-90
gb|AAF82605.1| (AF144042) dTDP-glucose 4,6-dehydratase [Streptom... 330 1e-89
gb|AAD28704.1|AF101047_5 (AF101047) putative dTDP-D-glucose 4,6-... 329 3e-89
pir||G81242 dTDPglucose 4,6-dehydratase (EC 4.2.1.46) NMB0063, N... 329 3e-89
sp|P95780|RMLB_STRMU DTDP-GLUCOSE 4,6-DEHYDRATASE >gi|1813347|db... 329 3e-89
gb|AAB47842.1| (U61226) RfbB [Leptospira interrogans] >gi|581432... 329 3e-89
gb|AAF33465.1| (AF233324) 89% identity with E. coli dTDP-D-gluco... 329 3e-89
gb|AAC37049.1| (L09189) dTDP-D-glucose 4,6-dehydratase [Neisseri... 328 6e-89
gb|AAD12971.1| (AF078135) RmlB [Leptospira borgpetersenii] 328 6e-89
emb|CAB01951.1| (Z79692) ExpA9 [Sinorhizobium meliloti] 325 4e-88
gb|AAC70775.1| (AF097519) dTDP-D-glucose 4,6 dehydratase [Klebsi... 324 9e-88
gb|AAG09522.1|AF279621_1 (AF279621) dTDP-D-glucose-4,6-dehydrata... 324 9e-88
pir||H72588 probable dTDP-glucose 4,6-dehydratase APE1180 - Aero... 324 1e-87
sp|P44914|RFFG_HAEIN DTDP-GLUCOSE 4,6-DEHYDRATASE >gi|1075419|pi... 323 1e-87
gb|AAD31800.1|AF128273_3 (AF128273) TDP-glucose-4,6-dehydratase ... 323 2e-87
gb|AAG09509.1|AF279618_1 (AF279618) dTDP-D-glucose-4,6-dehydrata... 323 3e-87
gb|AAC12869.1| (AF044332) dTDP-D-glucose-4,6-dehydratase; RffG [... 323 3e-87
sp|P37777|RFBB_SHIFL DTDP-GLUCOSE 4,6-DEHYDRATASE >gi|1073703|pi... 323 3e-87
sp|P26391|RFBB_SALTY DTDP-GLUCOSE 4,6-DEHYDRATASE >gi|96840|pir|... 323 3e-87
gb|AAC78676.1| (AF094575) dTDP-glucose-4,6-dehydratase Cps19aN [... 322 3e-87
gb|AAG09498.1|AF279615_1 (AF279615) dTDP-D-glucose-4,6-dehydrata... 322 3e-87
gb|AAC68681.1| (AF079762) TDP-glucose-4,6-dehydratase [Streptomy... 322 4e-87
gb|AAD19915.1| (AF105113) dTDP-glucose-4,6-dehydratase [Streptoc... 321 6e-87
gb|AAC38674.1| (AF030359) dTDP-glucose-4,6-dehydratase [Streptoc... 321 6e-87
pir||G82014 dTDPglucose 4,6-dehydratase (EC 4.2.1.46) NMA0204 [i... 321 6e-87
gb|AAG09534.1|AF279624_1 (AF279624) dTDP-D-glucose-4,6-dehydrata... 321 6e-87
gb|AAC44971.1| (U09239) dTDP-glucose-4,6-dehydratase [Streptococ... 321 7e-87
gb|AAC38679.1| (AF030360) dTDP-glucose-4,6-dehydratase [Streptoc... 321 7e-87
gb|AAG09506.1|AF279617_1 (AF279617) dTDP-D-glucose-4,6-dehydrata... 321 7e-87
sp|P37759|RBB1_ECOLI DTDP-GLUCOSE 4,6-DEHYDRATASE >gi|7437240|pi... 321 1e-86
emb|CAB05932.1| (Z83335) dTDP-glucose 4,6-dehydratase [Streptoco... 321 1e-86
gb|AAG09537.1|AF279625_1 (AF279625) dTDP-D-glucose-4,6-dehydrata... 321 1e-86
sp|P27830|RFFG_ECOLI DTDP-GLUCOSE 4,6-DEHYDRATASE >gi|7437241|pi... 320 1e-86
gb|AAG09530.1|AF279623_1 (AF279623) dTDP-D-glucose-4,6-dehydrata... 320 1e-86
gb|AAG29802.1| (AF235050) dTDP-glucose 4,6-dehydratase [Streptom... 320 2e-86
pir||S75783 dTDPglucose 4,6-dehydratase (EC 4.2.1.46) - Synechoc... 319 2e-86
pir||B83000 dTDP-D-glucose 4,6-dehydratase PA5161 [imported] - P... 319 2e-86
gb|AAG35060.1|AF314183_2 (AF314183) dTDP-glucose-4,6-dehydratase... 319 2e-86
sp|P55462|RFBB_RHISN PROBABLE DTDP-GLUCOSE 4,6-DEHYDRATASE >gi|2... 319 3e-86
sp|P55293|RBB2_ECOLI DTDP-GLUCOSE 4,6-DEHYDRATASE >gi|7437235|pi... 319 4e-86
pir||I55054 dTDP-D-glucose 4,6-dehydratase - Escherichia coli 319 4e-86
gb|AAG09517.1|AF279620_1 (AF279620) dTDP-D-glucose-4,6-dehydrata... 319 4e-86
pir||S30682 hypothetical protein o355 - Escherichia coli >gi|148... 318 5e-86
gb|AAG09526.1|AF279622_1 (AF279622) dTDP-D-glucose-4,6-dehydrata... 318 5e-86
gb|AAC35922.1| (AF071085) putative dTDP-glucose-4,6-dehydratase ... 317 8e-86
gb|AAB66647.1| (U43540) rhamnose biosynthesis protein [Mycobacte... 317 1e-85
sp|P37761|RFBB_NEIGO DTDP-GLUCOSE 4,6-DEHYDRATASE >gi|628590|pir... 316 2e-85
emb|CAB39839.1| (AL049491) putative dTDP-(glucose or rhamnose)-4... 316 3e-85
gb|AAD31797.1|AF128272_2 (AF128272) TDP-glucose-4,6-dehydratase ... 315 6e-85
gb|AAG09513.1|AF279619_1 (AF279619) dTDP-D-glucose-4,6-dehydrata... 314 1e-84
pir||C75597 thymidine diphosphoglucose 4,6-dehydratase - Deinoco... 313 2e-84
gb|AAF00211.1|AF164960_7 (AF164960) dNDP-glucose 4,6-dehydratase... 313 2e-84
pir||S41534 dTDPglucose 4,6-dehydratase (EC 4.2.1.46) - Shigella... 312 3e-84
dbj|BAA84593.1| (AB032523) dTDP-glucose 4,6-dehydratase [Strepto... 312 3e-84
pir||S49054 dTDPglucose 4,6-dehydratase (EC 4.2.1.46) [similarit... 312 4e-84
emb|CAA77209.1| (Y18523) dTDP-glucose 4,6-dehydratase [Actinopla... 310 2e-83
gb|AAF59935.1| (AF237895) dTDP-D-glucose 4,6-dehydratase [Strept... 309 2e-83
pir||T51106 dTDPglucose 4,6-dehydratase (EC 4.2.1.46) [validated... 309 4e-83
sp|P39630|SPSJ_BACSU SPORE COAT POLYSACCHARIDE BIOSYNTHESIS PROT... 308 7e-83
gb|AAF01814.1|AF187532_10 (AF187532) putative dTDP-glucose-4,6-d... 305 4e-82
sp|P55295|RFBB_XANCA DTDP-GLUCOSE 4,6-DEHYDRATASE >gi|1073090|pi... 305 5e-82
pir||T48867 dTDPglucose 4,6-dehydratase (EC 4.2.1.46) [validated... 305 6e-82
gb|AAD05454.1| (AF064070) putative dTDP-D-glucose 4,6-dehydratas... 304 8e-82
emb|CAB61555.1| (AL133171) putative dehydratase [Streptomyces co... 302 3e-81
pir||B82828 dTDP-glucose 4,6-dehydratase XF0255 [imported] - Xyl... 298 8e-80
gb|AAD45555.1|U70376_20 (U70376) SpcJ [Streptomyces flavopersicus] 295 4e-79
sp|P29782|STRE_STRGR DTDP-GLUCOSE 4,6-DEHYDRATASE >gi|68393|pir|... 294 7e-79
dbj|BAB07083.1| (AP001518) spore coat polysaccharide synthesis (... 294 1e-78
pir||T30873 dNDP-glucose dehydratase - Streptomyces viridochromo... 292 5e-78
emb|CAA07387.1| (AJ006985) StrE [Streptomyces glaucescens] 291 8e-78
emb|CAB65206.1| (AJ007311) RmlB protein [Legionella pneumophila] 291 1e-77
pir||S58686 dTDPglucose 4,6-dehydratase (EC 4.2.1.46) graE - Str... 287 1e-76
gb|AAF73454.1|AF264025_5 (AF264025) putative dTDP-glucose 4, 6-d... 285 5e-76
prf||2208414C glucose phosphate thymidylate transferase [Strepto... 280 2e-74
gb|AAF78439.1|AC018748_18 (AC018748) Contains similarity to dTPD... 279 3e-74
gb|AAD30579.1|AC007260_10 (AC007260) Similar to dTDP-D-glucose 4... 279 4e-74
emb|CAC12984.1| (AJ250327) dTDP-glucose 4,6-dehydratase [Acetoba... 277 2e-73
gb|AAK41125.1| dTDP-Glucose 4,6-dehydratase (rfbB-1) [Sulfolobus... 274 1e-72
emb|CAB57474.1| (Y18930) dTDP-glucose 4,6-dehydratase (rfbB) [Su... 274 1e-72
gb|AAK41973.1| dTDP-Glucose 4,6-dehydratase (rfbB-3) [Sulfolobus... 273 1e-72
gb|AAG09488.1|AF279639_1 (AF279639) dTDP-D-glucose-4,6-dehydrata... 272 4e-72
gb|AAG09484.1|AF279635_1 (AF279635) dTDP-D-glucose-4,6-dehydrata... 271 8e-72
gb|AAG09475.1|AF279626_1 (AF279626) dTDP-D-glucose-4,6-dehydrata... 271 1e-71
gb|AAG09492.1|AF279643_1 (AF279643) dTDP-D-glucose-4,6-dehydrata... 270 1e-71
gb|AAG09494.1|AF279645_1 (AF279645) dTDP-D-glucose-4,6-dehydrata... 270 1e-71
gb|AAG09495.1|AF279646_1 (AF279646) dTDP-D-glucose-4,6-dehydrata... 270 1e-71
gi|7657641 dTDP-D-glucose 4,6-dehydratase [Homo sapiens] >gi|412... 243 2e-63
emb|CAC01395.1| (AJ131360) dTDP-glucose 4,6-dehydratase [Campylo... 230 2e-59
pir||T16444 hypothetical protein F53B1.4 - Caenorhabditis elegan... 219 3e-56
gb|AAK41933.1| dTDP-Glucose 4,6-dehydratase (rfbB-2) [Sulfolobus... 216 3e-55
emb|CAA75866.1| (Y15903) dTDP-glucose-4,6-dehydratase [Streptoco... 193 3e-48
pir||T15370 hypothetical protein C01F1.3 - Caenorhabditis elegan... 186 4e-46
gb|AAF31493.1|AF071521_1 (AF071521) putative TDP-glucose dehydra... 179 5e-44
pir||D70696 probable dtdp-glucose 4 - Mycobacterium tuberculosis... 159 6e-38
pir||A71183 probable UDP-glucose 4-epimerase - Pyrococcus horiko... 152 4e-36
gb|AAA65538.1| (L20496) UDP-N-acetyl-D-glucosamine-2-epimerase [... 150 2e-35
pir||D75143 udp-glucose 4-epimerase (gale-1) PAB2145 - Pyrococcu... 149 4e-35
pir||D81275 probable nucleotide sugar dehydratase Cj1319 [import... 148 7e-35
gb|AAG18701.1| (AE004975) UDP-glucose 4-epimerase; GalE2 [Haloba... 148 1e-34
sp|Q58455|YA55_METJA HYPOTHETICAL PROTEIN MJ1055 >gi|2127791|pir... 145 6e-34
sp|P35675|YGAE_ERWAM HYPOTHETICAL PROTEIN IN GALE 3'REGION >gi|1... 144 2e-33
gb|AAB84886.1| (AE000823) UDP-glucose 4-epimerase homolog [Metha... 139 3e-32
pir||C69149 conserved hypothetical protein MTH380 - Methanobacte... 139 3e-32
gb|AAK41108.1| UDP-glucose 4-epimerase (galE-2) [Sulfolobus solf... 138 7e-32
emb|CAB57495.1| (Y18930) dTDP-glucose 4,6-dehydratase [Sulfolobu... 138 7e-32
gb|AAB48319.1| (U29691) CDP-tyvelose epimerase [Yersinia pseudot... 134 1e-30
dbj|BAB07368.1| (AP001519) UDP-glucose 4-epimerase [Bacillus hal... 134 1e-30
pir||C72368 hypothetical protein TM0509 - Thermotoga maritima (s... 134 2e-30
pir||T35486 probable nucleotide-sugar dehydratase - Streptomyces... 132 4e-30
pir||G70415 nucleotide sugar epimerase - Aquifex aeolicus >gi|29... 130 3e-29
gb|AAD52168.1|AF144879_7 (AF144879) unknown [Leptospira interrog... 129 4e-29
gb|AAD12951.1| (AF078135) unknown [Leptospira borgpetersenii] 128 8e-29
pir||H71145 probable UDP-glucose 4-epimerase - Pyrococcus horiko... 128 8e-29
pir||C70562 probable DTDP-Glucose 4 - Mycobacterium tuberculosis... 126 3e-28
dbj|BAB07098.1| (AP001518) UDP-glucose 4-epimerase [Bacillus hal... 125 5e-28
pir||A75008 udp-glucose 4-epimerase (gale-2) PAB1299 - Pyrococcu... 125 7e-28
dbj|BAA25656.1| (AB005901) deduced dNDP-hexose 4,6-dehydratase [... 123 3e-27
sp|P14169|RFBE_SALTI CDP-TYVELOSE-2-EPIMERASE >gi|861175|gb|AAB4... 121 1e-26
dbj|BAB06023.1| (AP001515) nucleotide sugar epimerase (capsular ... 118 9e-26
sp|Q04973|VIPB_SALTI VI POLYSACCHARIDE BIOSYNTHESIS PROTEIN VIPB... 116 4e-25
dbj|BAA19651.1| (AB002668) unnamed protein product [Actinobacill... 115 1e-24
dbj|BAA82544.1| (AB030032) ORF18 [Actinobacillus actinomycetemco... 115 1e-24
sp|Q9KDV3|GALE_BACHD UDP-GLUCOSE 4-EPIMERASE (GALACTOWALDENASE) ... 114 2e-24
gb|AAC79582.1| (AC005727) putative nucleotide-sugar dehydratase ... 113 2e-24
pir||H69988 NDP-sugar epimerase homolog ytcB - Bacillus subtilis... 113 4e-24
pir||T00116 hypothetical protein 20 - Actinobacillus actinomycet... 112 5e-24
pir||C69148 dTDP-glucose 4,6-dehydratase related protein - Metha... 112 7e-24
emb|CAA18814.1| (AL023093) putative sugar dehyratase [Mycobacter... 112 7e-24
pir||A69184 UDP-glucose 4-epimerase - Methanobacterium thermoaut... 111 9e-24
pir||B33604 rfbE protein - Salmonella sp 111 2e-23
gb|AAF36926.1|AF221951_2 (AF221951) putative UDP-galactose 4-epi... 111 2e-23
gb|AAD50494.1|AF172324_12 (AF172324) WbnF [Escherichia coli] 110 2e-23
gb|AAG35361.1|AF317224_3 (AF317224) GDP-6-deoxy-D-lyxo-4-hexulos... 110 3e-23
sp|P33119|GALE_CORDI UDP-GLUCOSE 4-EPIMERASE (GALACTOWALDENASE) ... 109 3e-23
sp|O84903|GALE_LACCA UDP-GLUCOSE 4-EPIMERASE (GALACTOWALDENASE) ... 109 3e-23
pir||T51252 dTDPglucose 4,6-dehydratase (EC 4.2.1.46) [imported]... 109 6e-23
sp|P39858|CAPI_STAAU CAPI PROTEIN >gi|506705|gb|AAA64648.1| (U10... 108 8e-23
sp|P55180|GALE_BACSU UDP-GLUCOSE 4-EPIMERASE (GALACTOWALDENASE) ... 108 8e-23
pir||T45701 dTDP-glucose 4-6-dehydratases-like protein - Arabido... 108 1e-22
gb|AAG26471.1|AF285774_11 (AF285774) putative UDP-glucuronic aci... 108 1e-22
dbj|BAB07428.1| (AP001519) nucleotide sugar epimerase (biosynthe... 106 3e-22
dbj|BAB09774.1| (AB016890) dTDP-glucose 4-6-dehydratase [Arabido... 106 4e-22
sp|Q45291|GALE_BRELA UDP-GLUCOSE 4-EPIMERASE (GALACTOWALDENASE) ... 104 2e-21
emb|CAC14890.1| (AJ295156) d-TDP-glucose dehydratase [Phragmites... 104 2e-21
pir||T48135 nucleotide sugar epimerase-like protein - Arabidopsi... 103 3e-21
gb|AAG16750.1|AF277002_2 (AF277002) UDP-galactose 4-epimerase Ga... 103 3e-21
pdb|1KVS| Udp-Galactose 4-Epimerase Complexed With Udp-Phenol 102 6e-21
pir||T45892 dTDP-glucose 4-6-dehydratase-like protein - Arabidop... 102 6e-21
sp|Q56093|GALE_SALTI UDP-GLUCOSE 4-EPIMERASE (GALACTOWALDENASE) ... 101 1e-20
pir||F81317 UDPglucose 4-epimerase (EC 5.1.3.2) Cj1131c [importe... 101 1e-20
pir||G69142 GDP-D-mannose dehydratase - Methanobacterium thermoa... 101 1e-20
sp|P09147|GALE_ECOLI UDP-GLUCOSE 4-EPIMERASE (GALACTOWALDENASE) ... 101 2e-20
pdb|1UDB| Structure Of Udp-Galactose-4-Epimerase Complexed Wit... 101 2e-20
pdb|1KVR| Udp-Galactose 4-Epimerase Complexed With Udp-Phenol 100 2e-20
pdb|1KVT| Udp-Galactose 4-Epimerase Complexed With Udp-Phenol 100 2e-20
pdb|1KVQ| Udp-Galactose 4-Epimerase Complexed With Udp-Phenol 100 2e-20
pdb|1KVU| Udp-Galactose 4-Epimerase Complexed With Udp-Phenol 99 5e-20
pdb|1A9Y| Udp-Galactose 4-Epimerase Mutant S124aY149F COMPLEXE... 99 7e-20
pdb|1A9Z| Udp-Galactose 4-Epimerase Mutant S124aY149F COMPLEXE... 99 7e-20
pir||S75089 UDP-glucose 4-epimerase - Synechocystis sp. (strain ... 98 2e-19
sp|P21977|GALE_STRTR UDP-GLUCOSE 4-EPIMERASE (GALACTOWALDENASE) ... 97 3e-19
sp|P22715|GALE_SALTY UDP-GLUCOSE 4-EPIMERASE (GALACTOWALDENASE) ... 95 1e-18
gb|AAF25549.1|AF109295_4 (AF109295) GalE [Staphylococcus carnosus] 94 3e-18
gi|6319493 UDP-glucose 4-epimerase; Gal10p [Saccharomyces cerevi... 92 9e-18
sp|P96995|GALE_STRMU UDP-GLUCOSE 4-EPIMERASE (GALACTOWALDENASE) ... 92 1e-17
gb|AAD25749.1|AC007060_7 (AC007060) Strong similarity to F19I3.8... 91 1e-17
gb|AAA57872.1| (U09349) UDP-glucose 4-epimerase [Azospirillum br... 91 2e-17
sp|Q9T0A7|GAE3_ARATH PROBABLE UDP-GLUCOSE 4-EPIMERASE (GALACTOWA... 89 6e-17
pir||F82419 UDP-glucose 4-epimerase VCA0774 [imported] - Vibrio ... 89 6e-17
pir||S74751 CDP-glucose 4,6-dehydratase - Synechocystis sp. (str... 88 1e-16
pir||S74768 UDPglucose 4-epimerase (EC 5.1.3.2) - Synechocystis ... 88 2e-16
sp|Q57301|GALE_YEREN UDP-GLUCOSE 4-EPIMERASE (GALACTOWALDENASE) ... 85 1e-15
gb|AAF78483.1|AC012187_3 (AC012187) Strong similarity to UDPgluc... 78 1e-13
sp|O65780|GAE1_CYATE UDP-GLUCOSE 4-EPIMERASE GEPI42 (GALACTOWALD... 78 1e-13
pir||S62783 UDPglucose 4-epimerase (EC 5.1.3.2) - Arabidopsis th... 76 7e-13
sp|P09609|GALX_KLULA GAL10 BIFUNCTIONAL PROTEIN [INCLUDES: UDP-G... 71 2e-11
>pir||B75098 dtdp-glucose 4,6-dehydratase (rfbb) PAB0785 - Pyrococcus abyssi
(strain Orsay) >gi|5458599|emb|CAB50087.1| (AJ248286)
dTDP-glucose 4,6-dehydratase (rfbB) [Pyrococcus abyssi]
Length = 333
Score = 693 bits (1770), Expect = 0.0
Identities = 333/333 (100%), Positives = 333/333 (100%)
Query: 1 MRILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDV 60
MRILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDV
Sbjct: 1 MRILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDV 60
Query: 61 ADFELVRELIKKVDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKENPGVRLV 120
ADFELVRELIKKVDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKENPGVRLV
Sbjct: 61 ADFELVRELIKKVDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKENPGVRLV 120
Query: 121 HISTDEVYGDILKGSFTEEDRLMPSSPYSATKAASDMLVLGWARTYGLNASITRCTNNYG 180
HISTDEVYGDILKGSFTEEDRLMPSSPYSATKAASDMLVLGWARTYGLNASITRCTNNYG
Sbjct: 121 HISTDEVYGDILKGSFTEEDRLMPSSPYSATKAASDMLVLGWARTYGLNASITRCTNNYG 180
Query: 181 PYQFPEKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRAIEAVLLKGEAREIYNIS 240
PYQFPEKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRAIEAVLLKGEAREIYNIS
Sbjct: 181 PYQFPEKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRAIEAVLLKGEAREIYNIS 240
Query: 241 AGEERTNLEVVRTILRIMDKDESLIEFVEDRPGHDIRYSLDSWKIIRELKWRPKYRFEEG 300
AGEERTNLEVVRTILRIMDKDESLIEFVEDRPGHDIRYSLDSWKIIRELKWRPKYRFEEG
Sbjct: 241 AGEERTNLEVVRTILRIMDKDESLIEFVEDRPGHDIRYSLDSWKIIRELKWRPKYRFEEG 300
Query: 301 IKKTVEWYLENEWWWKPLINERVLHPTPWKLEW 333
IKKTVEWYLENEWWWKPLINERVLHPTPWKLEW
Sbjct: 301 IKKTVEWYLENEWWWKPLINERVLHPTPWKLEW 333
>pir||G71151 probable dTDP-glucose 4,6-dehydratase - Pyrococcus horikoshii
>gi|3256817|dbj|BAA29500.1| (AP000002) 336aa long
hypothetical dTDP-glucose 4,6-dehydratase [Pyrococcus
horikoshii]
Length = 336
Score = 620 bits (1582), Expect = e-177
Identities = 284/333 (85%), Positives = 314/333 (94%)
Query: 1 MRILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDV 60
M++LVTGGMGFIGSNFIRYILEKH DWEVIN+DKL YGSNPANLKD++DDPRYTFVKGDV
Sbjct: 4 MKLLVTGGMGFIGSNFIRYILEKHPDWEVINIDKLGYGSNPANLKDLEDDPRYTFVKGDV 63
Query: 61 ADFELVRELIKKVDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKENPGVRLV 120
AD+ELV+EL++KVD +VH AAESHVDRSISSP+ FLHSNVIGTYTLLE+IR+ENP VR V
Sbjct: 64 ADYELVKELVRKVDGVVHLAAESHVDRSISSPEIFLHSNVIGTYTLLESIRRENPEVRFV 123
Query: 121 HISTDEVYGDILKGSFTEEDRLMPSSPYSATKAASDMLVLGWARTYGLNASITRCTNNYG 180
H+STDEVYGDILKGSFTE DRLMPSSPYSATKAASDMLVLGW RTY LNASITRCTNNYG
Sbjct: 124 HVSTDEVYGDILKGSFTENDRLMPSSPYSATKAASDMLVLGWTRTYNLNASITRCTNNYG 183
Query: 181 PYQFPEKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRAIEAVLLKGEAREIYNIS 240
PYQFPEKLIPKTIIRA +GLK+PIYGTGKNVRDWLYVEDHVRAIE VLLKGE+REIYNIS
Sbjct: 184 PYQFPEKLIPKTIIRASLGLKIPIYGTGKNVRDWLYVEDHVRAIELVLLKGESREIYNIS 243
Query: 241 AGEERTNLEVVRTILRIMDKDESLIEFVEDRPGHDIRYSLDSWKIIRELKWRPKYRFEEG 300
AGEE+TNLEVV+ ILR+M K E LIE VEDRPGHD+RYSLDSWKI R+LKWRPKY F+EG
Sbjct: 244 AGEEKTNLEVVKIILRLMGKGEELIELVEDRPGHDLRYSLDSWKITRDLKWRPKYTFDEG 303
Query: 301 IKKTVEWYLENEWWWKPLINERVLHPTPWKLEW 333
IKKT++WYL+NEWWWKPL++ER+LHPTPWKL+W
Sbjct: 304 IKKTIDWYLKNEWWWKPLVDERILHPTPWKLKW 336
>gi|11497937 dTDP-glucose 4,6-dehydratase (rfbB) [Archaeoglobus fulgidus]
>gi|7437239|pir||D69290 dTDP-glucose 4,6-dehydratase
(rfbB) homolog - Archaeoglobus fulgidus
>gi|2650312|gb|AAB90911.1| (AE001082) dTDP-glucose
4,6-dehydratase (rfbB) [Archaeoglobus fulgidus]
Length = 332
Score = 558 bits (1423), Expect = e-158
Identities = 259/333 (77%), Positives = 297/333 (88%), Gaps = 1/333 (0%)
Query: 1 MRILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDV 60
MRILVTGGMGFIGSNF+RY L H+ E++NLD L YGSNP NLKD+ +D RY+F+KGD+
Sbjct: 1 MRILVTGGMGFIGSNFVRYALA-HHQVEILNLDALKYGSNPENLKDLAEDERYSFIKGDI 59
Query: 61 ADFELVRELIKKVDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKENPGVRLV 120
D+ELV +LIKKVDA+V+FAAESHVDRSISSP F+ SN +G YT+LEA+RK NP VRLV
Sbjct: 60 NDYELVSDLIKKVDAVVNFAAESHVDRSISSPYAFIESNFLGVYTILEAVRKCNPEVRLV 119
Query: 121 HISTDEVYGDILKGSFTEEDRLMPSSPYSATKAASDMLVLGWARTYGLNASITRCTNNYG 180
H+STDEVYGDI KGSFTE+D LMPSSPYSA+KAA+DMLVLG+ARTY LNASITRCTNNYG
Sbjct: 120 HVSTDEVYGDIEKGSFTEKDGLMPSSPYSASKAAADMLVLGYARTYNLNASITRCTNNYG 179
Query: 181 PYQFPEKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRAIEAVLLKGEAREIYNIS 240
PYQFPEKLIPKTIIRAKM L VPIYGTG NVRDW+YVEDH RA+ V+ KGE RE+YNIS
Sbjct: 180 PYQFPEKLIPKTIIRAKMNLSVPIYGTGMNVRDWIYVEDHCRAVWEVMEKGERREVYNIS 239
Query: 241 AGEERTNLEVVRTILRIMDKDESLIEFVEDRPGHDIRYSLDSWKIIRELKWRPKYRFEEG 300
+GEERTNLE+V+TIL IM KDESLIE+VEDRPGHD+RYSLDSWKI+RELKWRPK FEEG
Sbjct: 240 SGEERTNLEIVKTILEIMGKDESLIEYVEDRPGHDVRYSLDSWKIMRELKWRPKISFEEG 299
Query: 301 IKKTVEWYLENEWWWKPLINERVLHPTPWKLEW 333
I++TVEWYL+NEWWW+PL +ER+LHPTPWKL W
Sbjct: 300 IRRTVEWYLQNEWWWRPLADERILHPTPWKLRW 332
>pir||H69105 dTDP-glucose 4,6-dehydratase - Methanobacterium thermoautotrophicum
(strain Delta H) >gi|2622920|gb|AAB86255.1| (AE000933)
dTDP-glucose 4,6-dehydratase [Methanobacterium
thermoautotrophicum]
Length = 336
Score = 386 bits (982), Expect = e-106
Identities = 184/316 (58%), Positives = 238/316 (75%), Gaps = 4/316 (1%)
Query: 2 RILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDVA 61
+ILVTGG GFIGSNFIRY+L++H + +INLD LTY N NL+ ++D+PRYTFV+G +
Sbjct: 3 KILVTGGAGFIGSNFIRYMLQEH-PYHIINLDALTYCGNLENLRGVEDEPRYTFVRGSIT 61
Query: 62 DFELVRELIKKVDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKENPGV-RLV 120
D +LV +IK VDA+++FAAESHVDRSI P+ F+ +N++GT TLLEA RK GV R +
Sbjct: 62 DRKLVDGIIKDVDAVINFAAESHVDRSIEDPEIFIRTNILGTQTLLEASRKH--GVERFI 119
Query: 121 HISTDEVYGDILKGSFTEEDRLMPSSPYSATKAASDMLVLGWARTYGLNASITRCTNNYG 180
ISTDEVYG KG FTEE L P+SPYSA+KA++D++V + RTYGL +ITRC+NNYG
Sbjct: 120 QISTDEVYGSAEKGYFTEETPLAPNSPYSASKASADLMVRAYHRTYGLPVNITRCSNNYG 179
Query: 181 PYQFPEKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRAIEAVLLKGEAREIYNIS 240
PYQFPEKLIP I A +P+YG G NVRDW++V DH RA++ VL +G E+YNI
Sbjct: 180 PYQFPEKLIPLMITNALENKPLPVYGDGMNVRDWIHVLDHCRAVDLVLHRGRVGEVYNIG 239
Query: 241 AGEERTNLEVVRTILRIMDKDESLIEFVEDRPGHDIRYSLDSWKIIRELKWRPKYRFEEG 300
ER N+E+V I+R + KDESLI FVEDRPGHD RY++D+ KI EL W+P Y FEEG
Sbjct: 240 GNSERRNIEIVELIVRELGKDESLIRFVEDRPGHDRRYAIDASKIRNELGWKPLYSFEEG 299
Query: 301 IKKTVEWYLENEWWWK 316
I++T+ WY++N WW+
Sbjct: 300 IRETIRWYIDNRDWWE 315
>pir||E70566 probable DTDP-GLUCOSE 4 - Mycobacterium tuberculosis (strain H37RV)
>gi|2104387|emb|CAB08730.1| (Z95390) rmlB [Mycobacterium
tuberculosis]
Length = 331
Score = 340 bits (864), Expect = 1e-92
Identities = 166/322 (51%), Positives = 223/322 (68%), Gaps = 8/322 (2%)
Query: 1 MRILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDV 60
MR+LVTGG GFIG+NF+ + +H D V LD LTY +L D++D R V+GD+
Sbjct: 1 MRLLVTGGAGFIGTNFVHSAVREHPDDAVTVLDALTYAGRRESLADVEDAIR--LVQGDI 58
Query: 61 ADFELVRELIKKVDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKENPGVRLV 120
D ELV +L+ + DA+VHFAAESHVD ++ +P+ FLH+NVIGT+T+LEA+R+ GVRL
Sbjct: 59 TDAELVSQLVAESDAVVHFAAESHVDNALDNPEPFLHTNVIGTFTILEAVRRH--GVRLH 116
Query: 121 HISTDEVYGDIL---KGSFTEEDRLMPSSPYSATKAASDMLVLGWARTYGLNASITRCTN 177
HISTDEVYGD+ + FTE PSSPYSATKA +DMLV W R+YG+ A+I+ C+N
Sbjct: 117 HISTDEVYGDLELDDRARFTESTPYNPSSPYSATKAGADMLVRAWVRSYGVRATISNCSN 176
Query: 178 NYGPYQFPEKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRAIEAVLLKGEAREIY 237
NYGPYQ EK IP+ I G + +YG G NVRDW++V+DH A+ +L +G Y
Sbjct: 177 NYGPYQHVEKFIPRQITNVLTGRRPKLYGAGANVRDWIHVDDHNSAVRRILDRGRIGRTY 236
Query: 238 NISAGEERTNLEVVRTILRIMDKDESLIEFVEDRPGHDIRYSLDSWKIIRELKWRPKYR- 296
IS+ ER NL V+RT+LR+MD+D + V DR GHD+RY++D + EL W PK+
Sbjct: 237 LISSEGERDNLTVLRTLLRLMDRDPDDFDHVTDRVGHDLRYAIDPSTLYDELCWAPKHTD 296
Query: 297 FEEGIKKTVEWYLENEWWWKPL 318
FEEG++ T++WY +NE WW+PL
Sbjct: 297 FEEGLRTTIDWYRDNESWWRPL 318
>gb|AAD13546.1| (AF080235) NDP-hexose 4,6-dehydratase homolog [Streptomyces
cyanogenus]
Length = 326
Score = 339 bits (859), Expect = 4e-92
Identities = 170/319 (53%), Positives = 223/319 (69%), Gaps = 7/319 (2%)
Query: 2 RILVTGGMGFIGSNFIRYIL-EKHNDWE---VINLDKLTYGSNPANLKDIQDDPRYTFVK 57
+IL+TGG GFIGS+++R +L + + DW+ V LDKLTY N NL + PR TFV+
Sbjct: 3 KILITGGAGFIGSHYVRTLLNDGYEDWKGAHVTVLDKLTYAGNRDNLPEAH--PRLTFVQ 60
Query: 58 GDVADFELVRELIKKVDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKENPGV 117
GD+ DFEL+ EL+ DA+VHFAAESHVDRS+ S + F+H+NV GT LL+A+
Sbjct: 61 GDICDFELLLELLPGHDAVVHFAAESHVDRSLESAEEFVHTNVTGTQRLLDAVLATRVK- 119
Query: 118 RLVHISTDEVYGDILKGSFTEEDRLMPSSPYSATKAASDMLVLGWARTYGLNASITRCTN 177
R+VH+STDEVYG I +GS+TEE L P+SPYSA+KAASD+L + RT+GL+ SITRC+N
Sbjct: 120 RVVHVSTDEVYGSIDEGSWTEEWPLAPNSPYSASKAASDLLARSYWRTHGLDLSITRCSN 179
Query: 178 NYGPYQFPEKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRAIEAVLLKGEAREIY 237
NYGPYQ PEKLIP + G +VP+YG G N+R+WL+V+DH RAI+ VL KG A EIY
Sbjct: 180 NYGPYQHPEKLIPLFVTNLLEGEQVPLYGDGGNIREWLHVDDHCRAIDLVLNKGRAGEIY 239
Query: 238 NISAGEERTNLEVVRTILRIMDKDESLIEFVEDRPGHDIRYSLDSWKIIRELKWRPKYRF 297
NI G E+TN + ++ + +D S + V DR HD+RYSLD KI EL + P+ F
Sbjct: 240 NIGGGNEQTNRAITERLIALTGQDWSKVRHVPDRKAHDLRYSLDESKIREELGYAPRITF 299
Query: 298 EEGIKKTVEWYLENEWWWK 316
E+G+ TV WY +N WWK
Sbjct: 300 EQGLADTVAWYHDNPGWWK 318
>pir||T00102 dTDPglucose 4,6-dehydratase (EC 4.2.1.46) - Actinobacillus
actinomycetemcomitans >gi|3132254|dbj|BAA28131.1|
(AB010415) dTDP-D-glucose-4,6-dehydratase
[Actinobacillus actinomycetemcomitans]
Length = 355
Score = 339 bits (859), Expect = 4e-92
Identities = 167/341 (48%), Positives = 227/341 (65%), Gaps = 24/341 (7%)
Query: 3 ILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDVAD 62
ILVTGG GFIGS +RYI+E D V+N+DKLTY N +L+ ++++PRY F + D+ D
Sbjct: 5 ILVTGGAGFIGSAVVRYIIENTQD-SVVNVDKLTYAGNLESLETVKNNPRYIFEQVDICD 63
Query: 63 FELVRELIKK--VDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIR--------K 112
+ + + ++ D ++H AAESHVDRSI P F+ +N++GTY LLEA R +
Sbjct: 64 AKALARIFEQHQPDVVMHLAAESHVDRSIDGPAAFIETNIVGTYILLEAARAYWSSLNDE 123
Query: 113 ENPGVRLVHISTDEVYGDI--LKGSFTEEDRLMPSSPYSATKAASDMLVLGWARTYGLNA 170
+ G R HISTDEVYGD+ K FTE PSSPYSA+KA+SD LV W RTY L
Sbjct: 124 KKAGFRFHHISTDEVYGDLDGTKNLFTETTPYSPSSPYSASKASSDHLVRAWLRTYSLPT 183
Query: 171 SITRCTNNYGPYQFPEKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRAIEAVLLK 230
+T C+NNYGP+ FPEKLIP I+ A G +P+YG G+ +RDWL+VEDH RA+ V+ +
Sbjct: 184 IVTNCSNNYGPFHFPEKLIPLIILNALDGKPLPVYGNGQQIRDWLFVEDHARALYKVVTE 243
Query: 231 GEAREIYNISAGEERTNLEVVRTILRIMD-----------KDESLIEFVEDRPGHDIRYS 279
G+ E YNI E+ N++VVRTI +++ K E LI +V+DRPGHD+RY+
Sbjct: 244 GKIGETYNIGGHNEKANIDVVRTICALLEELVPNKPAGVTKYEDLITYVKDRPGHDVRYA 303
Query: 280 LDSWKIIRELKWRPKYRFEEGIKKTVEWYLENEWWWKPLIN 320
+D+ KI REL W+P+ FE GI+KTVEWYL N+ WW +++
Sbjct: 304 IDATKISRELGWKPQETFESGIRKTVEWYLNNQKWWSRVLD 344
>gb|AAG18457.1|AF306787_1 (AF306787) AprE [Streptomyces tenebrarius]
Length = 332
Score = 339 bits (859), Expect = 4e-92
Identities = 172/324 (53%), Positives = 220/324 (67%), Gaps = 7/324 (2%)
Query: 1 MRILVTGGMGFIGSNFIRYIL----EKHNDWEVINLDKLTYGSNPANLKDIQD--DPRYT 54
MR+LVTGG GFIGS+++R +L D EV+ LDKLTY N ANL + D R
Sbjct: 1 MRVLVTGGAGFIGSHYVRELLGGAYPAFADAEVVVLDKLTYAGNEANLAPVADAAGSRLR 60
Query: 55 FVKGDVADFELVRELIKKVDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKEN 114
FV+GD+ D ELVR L+ VD +VHFAAESHVDRSI F+ +NV+GT TLL+A +
Sbjct: 61 FVRGDICDAELVRTLMTGVDVVVHFAAESHVDRSILGATEFVMTNVLGTQTLLQAALEAG 120
Query: 115 PGVRLVHISTDEVYGDILKGSFTEEDRLMPSSPYSATKAASDMLVLGWARTYGLNASITR 174
G + VH+STDEVYG I +GS+ E+ L P+SPYSA+KA+SD+L + RT+GL +TR
Sbjct: 121 VG-KFVHVSTDEVYGSIDEGSWPEDHPLEPNSPYSASKASSDLLARAFHRTHGLPVCVTR 179
Query: 175 CTNNYGPYQFPEKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRAIEAVLLKGEAR 234
C+NNYGPYQFPEK+IP + G VP+YG G NVRDWL+V+DH R I+ V+ G
Sbjct: 180 CSNNYGPYQFPEKVIPLFVTNLMDGRPVPLYGDGLNVRDWLHVDDHCRGIQLVVEGGRPG 239
Query: 235 EIYNISAGEERTNLEVVRTILRIMDKDESLIEFVEDRPGHDIRYSLDSWKIIRELKWRPK 294
E+YNI G E TN E+ +L +M D S++E V DR GHD RYS+D KI EL +RP+
Sbjct: 240 EVYNIGGGTELTNRELTERLLAVMGADWSMVEQVPDRKGHDRRYSVDITKISTELGYRPR 299
Query: 295 YRFEEGIKKTVEWYLENEWWWKPL 318
FEEG+ +TV WY EN WW+PL
Sbjct: 300 VPFEEGLARTVAWYRENREWWEPL 323
>gb|AAA68211.1| (L37354) thymidine diphosphoglucose 4,6-dehydratase
[Saccharopolyspora erythraea]
Length = 329
Score = 338 bits (857), Expect = 7e-92
Identities = 163/322 (50%), Positives = 220/322 (67%), Gaps = 5/322 (1%)
Query: 1 MRILVTGGMGFIGSNFIRYIL----EKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFV 56
MR+LVTGG GFIGS+++R +L +V+ LDKLTY N NL+ + DDPR+ FV
Sbjct: 1 MRVLVTGGAGFIGSHYVRQLLGGAYPAFAGADVVVLDKLTYAGNEENLRPVADDPRFRFV 60
Query: 57 KGDVADFELVRELIKKVDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKENPG 116
+GD+ ++++V E++++VD +VHFAAE+HVDRSI +F+ +NV+GT TLL+ N
Sbjct: 61 RGDICEWDVVSEVMREVDVVVHFAAETHVDRSILGASDFVVTNVVGTNTLLQGALAANVS 120
Query: 117 VRLVHISTDEVYGDILKGSFTEEDRLMPSSPYSATKAASDMLVLGWARTYGLNASITRCT 176
+ VH+STDEVYG I GS+ E+ L P+SPYSA KA SD++ + RT+GL ITRC+
Sbjct: 121 -KFVHVSTDEVYGTIEHGSWPEDHLLEPNSPYSAAKAGSDLIARAYHRTHGLPVCITRCS 179
Query: 177 NNYGPYQFPEKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRAIEAVLLKGEAREI 236
NNYGPYQFPEK++P I G +VP+YG G NVRDWL+V DH R I+ V G A EI
Sbjct: 180 NNYGPYQFPEKVLPLFITNLMDGRRVPLYGDGLNVRDWLHVTDHCRGIQLVAESGRAGEI 239
Query: 237 YNISAGEERTNLEVVRTILRIMDKDESLIEFVEDRPGHDIRYSLDSWKIIRELKWRPKYR 296
YNI G E TN E+ +L +M +D S+++ V DR GHD RYS+D KI EL + P
Sbjct: 240 YNIGGGTELTNKELTERVLELMGQDWSMVQPVTDRKGHDRRYSVDHTKISEELGYEPVVP 299
Query: 297 FEEGIKKTVEWYLENEWWWKPL 318
FE G+ +T+EWY +N WW+PL
Sbjct: 300 FERGLAETIEWYRDNRAWWEPL 321
>gb|AAF13998.1|AF201913_1 (AF201913) SgcA [Streptomyces globisporus]
Length = 332
Score = 338 bits (857), Expect = 7e-92
Identities = 170/322 (52%), Positives = 214/322 (65%), Gaps = 5/322 (1%)
Query: 1 MRILVTGGMGFIGSNFIRYILEKH----NDWEVINLDKLTYGSNPANLKDIQDDPRYTFV 56
MR+LVTGG GFIGS F+R L D V LDKLTY NPANL + PRYTFV
Sbjct: 1 MRMLVTGGAGFIGSQFVRATLHGELPGSEDARVTVLDKLTYSGNPANLTSVAAHPRYTFV 60
Query: 57 KGDVADFELVRELIKKVDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKENPG 116
+GD D +V E++ D IVHFAAESHVDRSI + F+ +NV+GT TLLEA + G
Sbjct: 61 QGDTVDPRVVDEVVAGHDVIVHFAAESHVDRSIDTATRFVTTNVLGTQTLLEAALRHGVG 120
Query: 117 VRLVHISTDEVYGDILKGSFTEEDRLMPSSPYSATKAASDMLVLGWARTYGLNASITRCT 176
R VH+STDEVYG I GS+TE+ L P+ PY+A+KA SD++ L W RT GL+ +TRCT
Sbjct: 121 -RFVHVSTDEVYGSIASGSWTEDTPLAPNVPYAASKAGSDLMALAWHRTRGLDVVVTRCT 179
Query: 177 NNYGPYQFPEKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRAIEAVLLKGEAREI 236
NNYGPYQ+PEK+IP + GL+VP+YG G + RDWL+V DH RAI+ V+ G A E+
Sbjct: 180 NNYGPYQYPEKVIPLFVTNILDGLRVPLYGDGAHRRDWLHVSDHCRAIQMVMNSGRAGEV 239
Query: 237 YNISAGEERTNLEVVRTILRIMDKDESLIEFVEDRPGHDIRYSLDSWKIIRELKWRPKYR 296
Y+I G E +N E+ +L D S ++ V DR GHD RYSLD KI +EL + P
Sbjct: 240 YHIGGGTELSNEELTGLLLTACGTDWSCVDRVADRQGHDRRYSLDITKIRQELGYEPLVA 299
Query: 297 FEEGIKKTVEWYLENEWWWKPL 318
FE+G+ TV+WY EN WW+PL
Sbjct: 300 FEDGLAATVKWYHENRSWWQPL 321
>dbj|BAA94402.1| (AB041266) dTDP-D-glucose 4,6-dehydratase [Actinobacillus
actinomycetemcomitans]
Length = 355
Score = 337 bits (856), Expect = 9e-92
Identities = 166/341 (48%), Positives = 226/341 (65%), Gaps = 24/341 (7%)
Query: 3 ILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDVAD 62
IL+TGG GFIGS +RYI+E D V+N+DKLTY N +L+ ++++PRY F + D+ D
Sbjct: 5 ILITGGAGFIGSAVVRYIIENTQD-SVVNVDKLTYAGNLESLEAVKNNPRYIFEQVDICD 63
Query: 63 FELVRELIKK--VDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIR--------K 112
+ + + ++ DA++H AAESHVDRSI P F+ +N++GTY LLEA R +
Sbjct: 64 AKALARIFEQHQPDAVMHLAAESHVDRSIDGPATFIETNIVGTYILLEAARAYWSSLNDE 123
Query: 113 ENPGVRLVHISTDEVYGDI--LKGSFTEEDRLMPSSPYSATKAASDMLVLGWARTYGLNA 170
+ G R HISTDEVYGD+ FTE PSSPYSA+KA+SD LV W RTY L
Sbjct: 124 KKAGFRFHHISTDEVYGDLDGTNNLFTETTPYSPSSPYSASKASSDHLVRAWLRTYSLPT 183
Query: 171 SITRCTNNYGPYQFPEKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRAIEAVLLK 230
+T C+NNYGP+ FPEKLIP I+ A G +P+YG G+ +RDWL+VEDH RA+ V+ +
Sbjct: 184 IVTNCSNNYGPFHFPEKLIPLIILNALDGKPLPVYGNGQQIRDWLFVEDHARALYKVVTE 243
Query: 231 GEAREIYNISAGEERTNLEVVRTILRIMD-----------KDESLIEFVEDRPGHDIRYS 279
G+ E YNI E+ N++VVRTI +++ K E LI +V+DRPGHD+RY+
Sbjct: 244 GKIGETYNIGGHNEKANIDVVRTICALLEELVPDKPAGVTKYEDLITYVKDRPGHDVRYA 303
Query: 280 LDSWKIIRELKWRPKYRFEEGIKKTVEWYLENEWWWKPLIN 320
+D+ KI REL W+P+ FE GI+KTVEWYL N WW +++
Sbjct: 304 IDATKISRELGWKPQETFESGIRKTVEWYLNNRKWWSRVLD 344
>gb|AAF67513.1|AF170880_20 (AF170880) NovT [Streptomyces spheroides]
Length = 336
Score = 335 bits (851), Expect = 3e-91
Identities = 169/322 (52%), Positives = 214/322 (65%), Gaps = 5/322 (1%)
Query: 1 MRILVTGGMGFIGSNFIRYILEK----HNDWEVINLDKLTYGSNPANLKDIQDDPRYTFV 56
MRILVTGG GFIGS F+R L + +V LDKLTY N NL I D Y FV
Sbjct: 1 MRILVTGGAGFIGSEFVRATLRGTLPGSSGTQVTVLDKLTYSGNVLNLAPIADLRNYRFV 60
Query: 57 KGDVADFELVRELIKKVDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKENPG 116
+GD+ D +LV +++ DAIVHFAAE+HVDRSI S +F+ +N +GT LLEA + G
Sbjct: 61 RGDICDQDLVDDVVAGHDAIVHFAAETHVDRSIGSAASFVRTNAMGTQVLLEAASRHRLG 120
Query: 117 VRLVHISTDEVYGDILKGSFTEEDRLMPSSPYSATKAASDMLVLGWARTYGLNASITRCT 176
R VHISTDEVYG I +G++ EE + P++PY+A KAA D+L L W RT+GL+ +TRCT
Sbjct: 121 -RFVHISTDEVYGSIPEGAWDEESPVAPNAPYAAAKAAGDLLALAWHRTHGLDVVVTRCT 179
Query: 177 NNYGPYQFPEKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRAIEAVLLKGEAREI 236
NNYGPYQ+PEKLIP G +VP+YG G N R WL+V DH RAI+ VLL G A E+
Sbjct: 180 NNYGPYQYPEKLIPLFTTNVMDGQQVPVYGEGHNRRQWLHVSDHCRAIQLVLLGGRAGEV 239
Query: 237 YNISAGEERTNLEVVRTILRIMDKDESLIEFVEDRPGHDIRYSLDSWKIIRELKWRPKYR 296
Y+I G E TNLE+ IL+ ++ V DRPGHD RYSLD+ KI EL + P+
Sbjct: 240 YHIGGGTELTNLELAEQILKSCGAGWDMVRHVPDRPGHDFRYSLDTTKIRTELGFSPRVA 299
Query: 297 FEEGIKKTVEWYLENEWWWKPL 318
F +G+ +TVEWY +N WW+PL
Sbjct: 300 FADGLVETVEWYRDNRAWWEPL 321
>dbj|BAA19633.1| (AB002668) dTDP-D-glucose-4,6-dehydratase [Actinobacillus
actinomycetemcomitans]
Length = 355
Score = 335 bits (850), Expect = 4e-91
Identities = 167/341 (48%), Positives = 225/341 (65%), Gaps = 24/341 (7%)
Query: 3 ILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDVAD 62
ILVTGG GFIGS +RYI+E D V+N+DKLTY N +L+ ++++PRY F + D+ D
Sbjct: 5 ILVTGGAGFIGSAVVRYIIENTQD-SVVNVDKLTYAGNLESLEAVKNNPRYIFEQVDICD 63
Query: 63 FELVRELIKK--VDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIR--------K 112
+ + + ++ DA++H AAESHVDRSI P F+ +N++GTY LLEA R +
Sbjct: 64 AKALARIFEQHQPDAVMHLAAESHVDRSIDGPATFIETNIVGTYILLEAARAYWSSLIDE 123
Query: 113 ENPGVRLVHISTDEVYGDI--LKGSFTEEDRLMPSSPYSATKAASDMLVLGWARTYGLNA 170
+ G R HISTDEVYGD+ FTE PSSPYSA+KA+SD LV W RTY L
Sbjct: 124 KKAGFRFHHISTDEVYGDLDGTNNLFTETTPYSPSSPYSASKASSDHLVRAWLRTYSLPT 183
Query: 171 SITRCTNNYGPYQFPEKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRAIEAVLLK 230
+T C+NNYGP FPEKLIP I+ A G +P+YG G+ +RDWL+VEDH RA+ V+ +
Sbjct: 184 IVTNCSNNYGPKVFPEKLIPLIILNALDGKPLPVYGNGQQIRDWLFVEDHARALYKVVTE 243
Query: 231 GEAREIYNISAGEERTNLEVVRTILRIMD-----------KDESLIEFVEDRPGHDIRYS 279
G+ E YNI E+ N++VVRTI +++ K E LI +V+DRPGHD+RY+
Sbjct: 244 GKIGETYNIGGHNEKANIDVVRTICALLEELVPDKPAGVTKYEDLITYVKDRPGHDVRYA 303
Query: 280 LDSWKIIRELKWRPKYRFEEGIKKTVEWYLENEWWWKPLIN 320
+D+ KI REL W+P+ FE GI+KTVEWYL N WW +++
Sbjct: 304 IDATKISRELGWKPQETFESGIRKTVEWYLNNRKWWSRVLD 344
>dbj|BAA82532.1| (AB030032) dTDP-D-glucose 4,6-dehydratase [Actinobacillus
actinomycetemcomitans]
Length = 355
Score = 334 bits (847), Expect = 1e-90
Identities = 166/341 (48%), Positives = 225/341 (65%), Gaps = 24/341 (7%)
Query: 3 ILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDVAD 62
ILVTGG GFIGS +RYI+E D V+N+DKLTY N +L+ ++++PRYTF + D+ D
Sbjct: 5 ILVTGGAGFIGSAVVRYIIENTQD-SVVNVDKLTYAGNLESLEAVKNNPRYTFEQVDICD 63
Query: 63 FELVRELIK--KVDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIR--------K 112
+ + + + + DA++H AAESHVDRSI P F+ +N++GTY LLEA R +
Sbjct: 64 AKALARIFQQHRPDAVMHLAAESHVDRSIDGPAAFIETNIVGTYILLEAARAYWNSLNDE 123
Query: 113 ENPGVRLVHISTDEVYGDI--LKGSFTEEDRLMPSSPYSATKAASDMLVLGWARTYGLNA 170
+ R HISTDEVYGD+ F E PSSPYSA+KA+SD LV W RTY L
Sbjct: 124 KKAVFRFHHISTDEVYGDLDGTNNLFIETTPYSPSSPYSASKASSDHLVRAWLRTYSLPT 183
Query: 171 SITRCTNNYGPYQFPEKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRAIEAVLLK 230
+T C+NNYGP+ FPEKLIP I+ A G +P+YG G+ +RDWL+VEDH RA+ V+ +
Sbjct: 184 IVTNCSNNYGPFHFPEKLIPLIILNALDGKPLPVYGNGQQIRDWLFVEDHARALYKVVAE 243
Query: 231 GEAREIYNISAGEERTNLEVVRTILRIMD-----------KDESLIEFVEDRPGHDIRYS 279
G+ E YNI E+ N++VVRTI +++ K E LI +V+DRPGHD+RY+
Sbjct: 244 GKIGETYNIGGHNEKANIDVVRTICALLEELVPNKPAGVTKYEDLITYVKDRPGHDVRYA 303
Query: 280 LDSWKIIRELKWRPKYRFEEGIKKTVEWYLENEWWWKPLIN 320
+D+ KI REL W+P+ FE GI+KTVEWYL N WW +++
Sbjct: 304 IDATKISRELGWKPQETFESGIRKTVEWYLNNRKWWSRVLD 344
>gb|AAC44074.1| (U51197) dTDP-D-glucose-4,6-dehydratase [Sphingomonas sp. S88]
Length = 353
Score = 333 bits (845), Expect = 2e-90
Identities = 165/336 (49%), Positives = 219/336 (65%), Gaps = 23/336 (6%)
Query: 4 LVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDVADF 63
LVTGG GFIGS +R+++ + VINLDKLTY NPA+L I++ P Y FV D+AD
Sbjct: 6 LVTGGAGFIGSAVVRHLVRQGA--RVINLDKLTYAGNPASLTAIENAPNYRFVHADIADT 63
Query: 64 ELVRELIKK--VDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRK--------E 113
+ L+++ VD ++H AAESHVDRSI P F+ +NV+GT+ LL+A + +
Sbjct: 64 ATILPLLREEQVDVVMHLAAESHVDRSIDGPGEFIETNVVGTFKLLQAALQYWRELEGEK 123
Query: 114 NPGVRLVHISTDEVYGDIL--KGSFTEEDRLMPSSPYSATKAASDMLVLGWARTYGLNAS 171
R HISTDEV+GD+ G FTEE PSSPYSA+KAASD LV W TYGL
Sbjct: 124 REAFRFHHISTDEVFGDLPFDSGIFTEETPYDPSSPYSASKAASDHLVRAWGHTYGLPVV 183
Query: 172 ITRCTNNYGPYQFPEKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRAIEAVLLKG 231
++ C+NNYGP+ FPEKLIP TI+ A G +P+YG G+N+RDWLYV+DH +A+ + G
Sbjct: 184 LSNCSNNYGPFHFPEKLIPLTILNALEGKPLPVYGKGENIRDWLYVDDHAKALATIATTG 243
Query: 232 EAREIYNISAGEERTNLEVVRTILRIMD---------KDESLIEFVEDRPGHDIRYSLDS 282
+ + YN+ ERTNL+VV TI ++D K LI FV DRPGHD RY++D+
Sbjct: 244 KVGQSYNVGGRNERTNLQVVETICDLLDQRIPLKDGKKRRELITFVTDRPGHDRRYAIDA 303
Query: 283 WKIIRELKWRPKYRFEEGIKKTVEWYLENEWWWKPL 318
K+ EL W+ + F+ GI T++WYLENEWWW P+
Sbjct: 304 TKLETELGWKAEENFDTGIAATIDWYLENEWWWGPI 339
>sp|P55294|RFBB_NEIMB DTDP-GLUCOSE 4,6-DEHYDRATASE >gi|7437244|pir||S42431 dTDPglucose
4,6-dehydratase (EC 4.2.1.46) - Neisseria meningitidis
(isolate B1940) >gi|388933|gb|AAA63157.1| (L09188)
TDP-glucose-dehydratase [Neisseria meningitidis]
Length = 360
Score = 332 bits (843), Expect = 3e-90
Identities = 170/341 (49%), Positives = 224/341 (64%), Gaps = 24/341 (7%)
Query: 3 ILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDVAD 62
ILVTGG GFIGS +R+I+ D V+NLDKLTY N +L DI D+PRY F + D+ D
Sbjct: 9 ILVTGGAGFIGSAVVRHIIRNTQD-SVVNLDKLTYAGNLESLTDIADNPRYAFEQVDICD 67
Query: 63 -FELVRELIK-KVDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIR--------K 112
EL R + + DA++H AAESHVDRSI S F+ +N++GT+ LLEA R +
Sbjct: 68 RAELDRVFAQHRPDAVMHLAAESHVDRSIGSAGEFIQTNIVGTFNLLEAARAYWQQMPSE 127
Query: 113 ENPGVRLVHISTDEVYGDI--LKGSFTEEDRLMPSSPYSATKAASDMLVLGWARTYGLNA 170
++ R HISTDEVYGD+ FTE PSSPYSA+KA+SD LV W RTYGL
Sbjct: 128 QHEAFRFHHISTDEVYGDLHGTDDLFTETTPYAPSSPYSASKASSDHLVRAWLRTYGLPT 187
Query: 171 SITRCTNNYGPYQFPEKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRAIEAVLLK 230
+T C+NNYGPY FPEKLIP I+ A G +P+YG G +RDWL+VEDH RA+ V+ +
Sbjct: 188 IVTNCSNNYGPYHFPEKLIPLMILNALDGKPLPVYGDGMQIRDWLFVEDHARALYQVVTE 247
Query: 231 GEAREIYNISAGEERTNLEVVRTILRIMD-----------KDESLIEFVEDRPGHDIRYS 279
G E YNI E+ N+EVV+TI +++ + E LI FV+DRPGHD+RY+
Sbjct: 248 GVVGETYNIGGHNEKANIEVVKTICTLLEELVPEKPAGVARYEDLITFVQDRPGHDVRYA 307
Query: 280 LDSWKIIRELKWRPKYRFEEGIKKTVEWYLENEWWWKPLIN 320
+D+ KI R+L W P FE G++KTV+WYL+N+ WW+ ++N
Sbjct: 308 VDAAKIRRDLGWLPLETFESGLRKTVQWYLDNKTWWQNVLN 348
>gb|AAF82605.1| (AF144042) dTDP-glucose 4,6-dehydratase [Streptomyces rimosus
subsp. paromomycinus]
Length = 317
Score = 330 bits (838), Expect = 1e-89
Identities = 168/317 (52%), Positives = 212/317 (65%), Gaps = 2/317 (0%)
Query: 1 MRILVTGGMGFIGSNFIRYILEKHNDWEVIN-LDKLTYGSNPANLKDIQDDPRYTFVKGD 59
M+ LVTGG GFIGS+F+R +L E + LD LTY N ANL+ +Q DPR FV+GD
Sbjct: 1 MKTLVTGGAGFIGSHFVRSLLADGTGQEAVTVLDALTYAGNLANLRSVQGDPRLRFVQGD 60
Query: 60 VADFELVRELIKKVDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKENPGVRL 119
+ D V EL+ DA+V+ AAESHVDRSI++ F +NV+GT TLLEA + GV +
Sbjct: 61 ILDSARVAELVAGHDAVVNLAAESHVDRSIANGAKFSSTNVLGTQTLLEAAVQAG-GVTV 119
Query: 120 VHISTDEVYGDILKGSFTEEDRLMPSSPYSATKAASDMLVLGWARTYGLNASITRCTNNY 179
VH+STDEVYG I GS+TEE+ L P+SPY+A KA SD+L L + RT+GL+ ITRC+NNY
Sbjct: 120 VHVSTDEVYGSIPIGSWTEEEPLAPNSPYAAAKAGSDLLALAYHRTHGLDVRITRCSNNY 179
Query: 180 GPYQFPEKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRAIEAVLLKGEAREIYNI 239
GPYQFPEK+IP I R G KVP+YG G +RDWL+V DH RAI VL G A EIYN+
Sbjct: 180 GPYQFPEKIIPLFITRLLQGRKVPLYGDGSQIRDWLHVVDHCRAIRLVLEGGRAGEIYNV 239
Query: 240 SAGEERTNLEVVRTILRIMDKDESLIEFVEDRPGHDIRYSLDSWKIIRELKWRPKYRFEE 299
G E TN + +L D +E V DR GHD RYS+D KI EL + P++ F+E
Sbjct: 240 GGGTELTNKHLTDRLLDACGADWDSVEHVADRKGHDQRYSVDWSKIRDELGYEPRHTFDE 299
Query: 300 GIKKTVEWYLENEWWWK 316
G+ TV WY +N WW+
Sbjct: 300 GLASTVSWYRQNRDWWR 316
>gb|AAD28704.1|AF101047_5 (AF101047) putative dTDP-D-glucose 4,6-dehydratase [Haemophilus
ducreyi]
Length = 346
Score = 329 bits (835), Expect = 3e-89
Identities = 169/339 (49%), Positives = 222/339 (64%), Gaps = 24/339 (7%)
Query: 1 MRILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDV 60
M++L+TGG GFIGS IRYI+ H D EVIN+DKLTY N A+L + RYTF + D+
Sbjct: 1 MKLLITGGAGFIGSAVIRYIIN-HTDDEVINVDKLTYAGNLASLSSVSQHKRYTFEQVDI 59
Query: 61 ADFELVRELIK--KVDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIR------- 111
D + E+ + D ++H AAESHVDRSI F+ +N+IGTYTLLE R
Sbjct: 60 NDSGRIAEIFYHYQPDKVMHLAAESHVDRSIEGSAPFIQTNIIGTYTLLETARSYWQSLD 119
Query: 112 -KENPGVRLVHISTDEVYGDILKGS--FTEEDRLMPSSPYSATKAASDMLVLGWARTYGL 168
++ HISTDEV+GD+ FTE+ MPSSPYSA+KAASD LV W RTYGL
Sbjct: 120 QQKKAQFLFHHISTDEVFGDLAHQPQRFTEQSAYMPSSPYSASKAASDHLVQAWYRTYGL 179
Query: 169 NASITRCTNNYGPYQFPEKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRAIEAVL 228
I+ C+NNYGPY FPEKLIP TI+ A G +P+YG G VRDWL+VEDH RA+ V+
Sbjct: 180 PTVISHCSNNYGPYHFPEKLIPLTILNALSGKPLPVYGDGLQVRDWLFVEDHARALYKVI 239
Query: 229 LKGEAREIYNISAGEERTNLEVVRTILRIMDK-----------DESLIEFVEDRPGHDIR 277
+G E YNI A ERTN+EVV+ I +++D+ ++LI V DRPGHD+R
Sbjct: 240 KQGRVGESYNIGASNERTNIEVVQAICQLLDELVPVKPNGIKTYQALITHVADRPGHDLR 299
Query: 278 YSLDSWKIIRELKWRPKYRFEEGIKKTVEWYLENEWWWK 316
Y++D+ KI ++L W+P+ F G++KTVEWYL ++ WW+
Sbjct: 300 YAIDASKITQQLGWQPQESFATGLRKTVEWYLAHKNWWQ 338
>pir||G81242 dTDPglucose 4,6-dehydratase (EC 4.2.1.46) NMB0063, NMB0079
[similarity] - Neisseria meningitidis (group B strain
MD58) >gi|7225283|gb|AAF40531.1| (AE002365)
dTDP-D-glucose 4,6-dehydratase [Neisseria meningitidis
MC58] >gi|7225297|gb|AAF40543.1| (AE002367)
dTDP-D-glucose 4,6-dehydratase [Neisseria meningitidis
MC58]
Length = 355
Score = 329 bits (835), Expect = 3e-89
Identities = 167/342 (48%), Positives = 225/342 (64%), Gaps = 24/342 (7%)
Query: 2 RILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDVA 61
+ILVTGG GFIGS +R+I+ D V+N+DKLTY N +L ++ D+PRY F + D+
Sbjct: 3 KILVTGGAGFIGSAVVRHIIRNTRD-AVVNVDKLTYAGNLESLTEVADNPRYAFEQVDIC 61
Query: 62 D-FELVRELIK-KVDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIR-------- 111
D EL R + + DA++H AAESHVDRSI S F+ +N++GT+ LLEA R
Sbjct: 62 DRAELDRVFAQYRPDAVMHLAAESHVDRSIGSAGEFIQTNIVGTFNLLEAARAYWQQMPS 121
Query: 112 KENPGVRLVHISTDEVYGDI--LKGSFTEEDRLMPSSPYSATKAASDMLVLGWARTYGLN 169
+++ R HISTDEVYGD+ FTE PSSPYSA+KA+SD LV W RTYGL
Sbjct: 122 EQHEAFRFHHISTDEVYGDLGGTDDLFTETAPYAPSSPYSASKASSDHLVRAWLRTYGLP 181
Query: 170 ASITRCTNNYGPYQFPEKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRAIEAVLL 229
+T C+NNYGPY FPEKLIP I+ A G +P+YG G +RDWL+VEDH RA+ V+
Sbjct: 182 TIVTNCSNNYGPYHFPEKLIPLMILNALDGKPLPVYGDGMQIRDWLFVEDHARALYQVVT 241
Query: 230 KGEAREIYNISAGEERTNLEVVRTILRIMD-----------KDESLIEFVEDRPGHDIRY 278
+G E YNI E+ N+EVV+TI +++ + E LI FV+DRPGHD+RY
Sbjct: 242 EGVVGETYNIGGHNEKANIEVVKTICALLEELAPEKPAGVARYEDLITFVQDRPGHDVRY 301
Query: 279 SLDSWKIIRELKWRPKYRFEEGIKKTVEWYLENEWWWKPLIN 320
++D+ KI R+L W P FE G++KTV+WYL+N+ WW+ ++N
Sbjct: 302 AVDAAKIRRDLGWLPLETFESGLRKTVQWYLDNKTWWQNVLN 343
>sp|P95780|RMLB_STRMU DTDP-GLUCOSE 4,6-DEHYDRATASE >gi|1813347|dbj|BAA11249.1| (D78182)
dTDP-glucose-4,6-dehydratase [Streptococcus mutans]
Length = 348
Score = 329 bits (834), Expect = 3e-89
Identities = 165/327 (50%), Positives = 216/327 (65%), Gaps = 16/327 (4%)
Query: 3 ILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDVAD 62
I+VTGG GFIGSNF+ Y+ H D V LDKLTY N ANL++I D R V GD+AD
Sbjct: 7 IIVTGGAGFIGSNFVHYVYNNHPDVHVTVLDKLTYAGNHANLEEILGD-RVELVVGDIAD 65
Query: 63 FELVRELIKKVDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKENPGVRLVHI 122
ELV +L K DAIVH+AAESH D S+ P F+++N +GTYTLLEA RK + +R H+
Sbjct: 66 SELVDKLAAKADAIVHYAAESHNDNSLKDPSPFIYTNFVGTYTLLEAARKYD--IRFHHV 123
Query: 123 STDEVYGDI-----LKG-------SFTEEDRLMPSSPYSATKAASDMLVLGWARTYGLNA 170
STDEVYGD+ L G FT E + PSSPYS+TKAASD++V W R++G+ A
Sbjct: 124 STDEVYGDLPLREDLPGHGEGPGEKFTAETKYNPSSPYSSTKAASDLIVKAWVRSFGVKA 183
Query: 171 SITRCTNNYGPYQFPEKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRAIEAVLLK 230
+I+ C+NNYGPYQ EK IP+ I G+K +YG GKNVRDW++ DH + A+L K
Sbjct: 184 TISNCSNNYGPYQHIEKFIPRQITNILSGIKPKLYGEGKNVRDWIHTNDHSTGVWAILTK 243
Query: 231 GEAREIYNISAGEERTNLEVVRTILRIMDKDESLIEFVEDRPGHDIRYSLDSWKIIRELK 290
G E Y I A E+ N EV+ IL M + + + V DR GHD+RY++DS K+ EL
Sbjct: 244 GRIGETYLIGADGEKNNKEVLELILEKMSQPKDAYDHVTDRAGHDLRYAIDSTKLREELG 303
Query: 291 WRPKY-RFEEGIKKTVEWYLENEWWWK 316
W+P++ FEEG++ T++WY E+E WWK
Sbjct: 304 WKPQFTNFEEGLEDTIKWYTEHEDWWK 330
>gb|AAB47842.1| (U61226) RfbB [Leptospira interrogans]
>gi|5814320|gb|AAD52188.1|AF144879_27 (AF144879) unknown
[Leptospira interrogans]
Length = 349
Score = 329 bits (834), Expect = 3e-89
Identities = 161/333 (48%), Positives = 221/333 (66%), Gaps = 14/333 (4%)
Query: 2 RILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDVA 61
+ILVTGG GFIGSNF+ IL +++V+ DKLTY N +L+ + D R+ FVK D+A
Sbjct: 3 KILVTGGAGFIGSNFVNLILNDTKEYQVVVFDKLTYAGNLRSLESWKKDSRFIFVKADIA 62
Query: 62 DFELVRELIK--KVDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKE----NP 115
+ E V + + K + I HFAAESHVDRSIS P+ F+ +NV+GT+ LL+A R +
Sbjct: 63 NKEEVSSIFQEHKFNYIAHFAAESHVDRSISGPEEFIKTNVLGTFYLLDAARLQWNGSYE 122
Query: 116 GVRLVHISTDEVYGDIL-KGSFTEEDRLMPSSPYSATKAASDMLVLGWARTYGLNASITR 174
G + +H+STDEV+G + G FTEE P+SPYSA+KA+SD +V + TY + T
Sbjct: 123 GKKFLHVSTDEVFGTLGDSGYFTEETPYAPNSPYSASKASSDHIVRSYYHTYHMPVVTTN 182
Query: 175 CTNNYGPYQFPEKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRAIEAVLLKGEAR 234
C+NNYGPY FPEKLIP I+ G +P+YG GKN+RDWLYV+DH A+ L +G
Sbjct: 183 CSNNYGPYHFPEKLIPLMILNCLQGKPLPVYGDGKNIRDWLYVKDHCEALRVALFQGLPG 242
Query: 235 EIYNISAGEERTNLEVVRTILRIMDK-------DESLIEFVEDRPGHDIRYSLDSWKIIR 287
E YNI E+ N+++V +I IMD+ LI++V+DRPGHD RY++D KI +
Sbjct: 243 ETYNIGTRNEKKNIDIVDSICSIMDELHPSGAPHSKLIQYVKDRPGHDFRYAIDPSKIEK 302
Query: 288 ELKWRPKYRFEEGIKKTVEWYLENEWWWKPLIN 320
EL W+PK+ FE +K+TV WYLENE WWK +++
Sbjct: 303 ELGWKPKFAFESALKETVRWYLENESWWKEILS 335
>gb|AAF33465.1| (AF233324) 89% identity with E. coli dTDP-D-glucose-4,6-dehydratase
(RFFG) (SP:P27830); contains similarity to Pfam family
PF01370 (NAD dependent epimerase/dehydratase family),
score=721.7, E=3.2e-213, N=1 [Salmonella typhimurium
LT2]
Length = 355
Score = 329 bits (834), Expect = 3e-89
Identities = 168/340 (49%), Positives = 216/340 (63%), Gaps = 24/340 (7%)
Query: 2 RILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDVA 61
RILVTGG GFIGS +R+I+ + D V+ +DKLTY N +L + R+ F K D+
Sbjct: 3 RILVTGGAGFIGSAVVRHIIHETAD-AVVVVDKLTYAGNLMSLASVAQSDRFAFEKVDIC 61
Query: 62 DFELVRELIKKV--DAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRK------- 112
D + + ++ D+++H AAESHVDRSI P F+ +N++GTYTLLEA R
Sbjct: 62 DRASLERVFQQYQPDSVMHLAAESHVDRSIDGPAAFIETNIVGTYTLLEAARAYWSALDA 121
Query: 113 -ENPGVRLVHISTDEVYGDILKGS--FTEEDRLMPSSPYSATKAASDMLVLGWARTYGLN 169
R HISTDEVYGD+ FTE PSSPYSA+KA+SD LV W RTYGL
Sbjct: 122 DAKAAFRFHHISTDEVYGDLHTADDFFTETTPYAPSSPYSASKASSDHLVRAWLRTYGLP 181
Query: 170 ASITRCTNNYGPYQFPEKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRAIEAVLL 229
+T C+NNYGPY FPEKLIP I+ A G +P+YG G+ +RDWLYVEDH RA+ V+
Sbjct: 182 TLVTNCSNNYGPYHFPEKLIPLMILNALAGKPLPVYGNGQQIRDWLYVEDHARALYHVVT 241
Query: 230 KGEAREIYNISAGEERTNLEVVRTILRIMDK-----------DESLIEFVEDRPGHDIRY 278
G E YNI ER NL+VVRTI ++++ LI FV+DRPGHD+RY
Sbjct: 242 NGAVGETYNIGGHNERKNLDVVRTICALLEELAPQKPQGVVNYHDLITFVDDRPGHDLRY 301
Query: 279 SLDSWKIIRELKWRPKYRFEEGIKKTVEWYLENEWWWKPL 318
++D+ KI REL W P+ FE G++KTV+WYL NE WWKP+
Sbjct: 302 AIDASKIARELGWTPQETFESGMRKTVQWYLANEAWWKPV 341
>gb|AAC37049.1| (L09189) dTDP-D-glucose 4,6-dehydratase [Neisseria meningitidis]
Length = 355
Score = 328 bits (832), Expect = 6e-89
Identities = 171/343 (49%), Positives = 225/343 (64%), Gaps = 26/343 (7%)
Query: 2 RILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDVA 61
+ILVTGG GFIGS +R+I+ D V+NLDKLTY N +L DI D+PRY F + D+
Sbjct: 3 KILVTGGAGFIGSAVVRHIIRNTQD-SVVNLDKLTYAGNLESLTDIADNPRYAFEQVDIC 61
Query: 62 D-FELVRELIK-KVDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIR-------- 111
D EL R + + DA++H AAESHVDRSI S F+ +N++GT+ LLEA R
Sbjct: 62 DRAELDRVFAQHRPDAVMHLAAESHVDRSIGSAGEFIQTNIVGTFNLLEAARAYWQQMPS 121
Query: 112 KENPGVRLVHISTDEVYGDILKGS---FTEEDRLMPSSPYSATKAASDMLVLGWARTYGL 168
++ R HISTDEVYGD L G+ FTE PSSPYSA+KA+SD LV W RTYGL
Sbjct: 122 EQYEAFRFHHISTDEVYGD-LSGTDDLFTETAPYAPSSPYSASKASSDHLVRAWLRTYGL 180
Query: 169 NASITRCTNNYGPYQFPEKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRAIEAVL 228
+T C+NNYG Y FPEKLIP I+ A G +P+YG G +RDWL+VEDH RA+ V+
Sbjct: 181 PTIVTNCSNNYGLYHFPEKLIPLMILNALDGKPLPVYGDGMQIRDWLFVEDHARALYQVV 240
Query: 229 LKGEAREIYNISAGEERTNLEVVRTILRIMD-----------KDESLIEFVEDRPGHDIR 277
+G E YNI E+ N+EVV+TI +++ + E LI FV+DRPGHD+R
Sbjct: 241 TEGVVGETYNIGGHNEKANIEVVKTICALLEELAPEKPAGVARYEDLITFVQDRPGHDVR 300
Query: 278 YSLDSWKIIRELKWRPKYRFEEGIKKTVEWYLENEWWWKPLIN 320
Y++D+ KI R+L W P FE G++KTV+WYL+N+ WW+ ++N
Sbjct: 301 YAVDAAKIRRDLGWLPLETFESGLRKTVQWYLDNKTWWQNVLN 343
>gb|AAD12971.1| (AF078135) RmlB [Leptospira borgpetersenii]
Length = 349
Score = 328 bits (832), Expect = 6e-89
Identities = 158/333 (47%), Positives = 223/333 (66%), Gaps = 14/333 (4%)
Query: 2 RILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDVA 61
+ILVTGG GFIGSNF+ IL ++ ++++I DKLTY N +L+ + DPR+ F+K D+A
Sbjct: 3 KILVTGGAGFIGSNFVNLILNENEEYQIIVFDKLTYAGNLKSLEYWKKDPRFIFIKADIA 62
Query: 62 DFELVRELIKK--VDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKE----NP 115
+ E V + ++ D + HFAAESHVDRSI P+ F+ +NV+GT+ LL+A R +
Sbjct: 63 NKENVFSIFQEHNFDYVAHFAAESHVDRSILGPEEFIKTNVLGTFYLLDAARLQWNGSYE 122
Query: 116 GVRLVHISTDEVYGDILK-GSFTEEDRLMPSSPYSATKAASDMLVLGWARTYGLNASITR 174
G + +H+STDEV+G + G FTEE P+SPYSA+KA SD +V + TY + T
Sbjct: 123 GKKFLHVSTDEVFGTLGDTGYFTEETPYAPNSPYSASKAGSDHIVRSYYHTYHMPVVTTN 182
Query: 175 CTNNYGPYQFPEKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRAIEAVLLKGEAR 234
C+NNYGPY FPEKLIP TI+ G +P+YG GKN+RDWLYV+DH A+ L +G
Sbjct: 183 CSNNYGPYHFPEKLIPLTILNCLQGKPLPVYGDGKNIRDWLYVKDHCEALRLALFQGLPG 242
Query: 235 EIYNISAGEERTNLEVVRTILRIMDK-------DESLIEFVEDRPGHDIRYSLDSWKIIR 287
E YNI E+ N+++V +I IMD+ LI++V+DRPGHD RY++D KI +
Sbjct: 243 ETYNIGTRNEKKNIDIVNSICSIMDEFHPSGVPHSKLIQYVKDRPGHDFRYAIDPSKIEK 302
Query: 288 ELKWRPKYRFEEGIKKTVEWYLENEWWWKPLIN 320
EL W+PK+ FE +++TV WYL+NE WWK +++
Sbjct: 303 ELGWKPKFVFESALRETVRWYLDNESWWKEILS 335
>emb|CAB01951.1| (Z79692) ExpA9 [Sinorhizobium meliloti]
Length = 356
Score = 325 bits (825), Expect = 4e-88
Identities = 163/343 (47%), Positives = 221/343 (63%), Gaps = 22/343 (6%)
Query: 1 MRILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDV 60
MR+LVTGG GFIGS R+++ + V+N+DKLTY + A+L+ ++ DP Y F + D+
Sbjct: 1 MRVLVTGGAGFIGSAVCRHLIRNGAE-RVVNVDKLTYAGSLASLRAVESDPHYAFYRADI 59
Query: 61 ADFELVRELIKK--VDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAI-------- 110
D +++ +++++ +DAI+H AAESHVDRSI SPD F+ +NV+GT LL A
Sbjct: 60 RDEQVLLQIMRRERIDAIMHLAAESHVDRSIESPDPFMETNVLGTVRLLNAALAYWSGLG 119
Query: 111 RKENPGVRLVHISTDEVYGDIL--KGSFTEEDRLMPSSPYSATKAASDMLVLGWARTYGL 168
+E R H+STDEV+GD+ +G F+EE R PSSPY+A+KAA+D W TYGL
Sbjct: 120 TEERGRFRFHHVSTDEVFGDLPFNRGIFSEETRYAPSSPYAASKAAADHFARAWYHTYGL 179
Query: 169 NASITRCTNNYGPYQFPEKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRAIEAVL 228
++ C+NNYGP+ FPEKLIP TII A +P+YG+G NVRDWL+V DH A+E V+
Sbjct: 180 PVVVSNCSNNYGPFHFPEKLIPLTIINAIEEKPLPLYGSGANVRDWLHVADHATALELVV 239
Query: 229 LKGEAREIYNISAGEERTNLEVVRTILRIM---------DKDESLIEFVEDRPGHDIRYS 279
+G E YNI A ER NL V+ I ++ D LI V DRPGHD RY+
Sbjct: 240 SRGRPGESYNIGARAERNNLSVMECICDLLDVRLPRKGGDSYRDLITLVPDRPGHDRRYA 299
Query: 280 LDSWKIIRELKWRPKYRFEEGIKKTVEWYLENEWWWKPLINER 322
+D K REL WRPK FE G+ +TV+W+L N WWW+P+ ER
Sbjct: 300 IDPSKAERELGWRPKRSFEGGLSETVDWFLANRWWWEPIRRER 342
>gb|AAC70775.1| (AF097519) dTDP-D-glucose 4,6 dehydratase [Klebsiella pneumoniae]
Length = 354
Score = 324 bits (822), Expect = 9e-88
Identities = 169/344 (49%), Positives = 219/344 (63%), Gaps = 25/344 (7%)
Query: 1 MRILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDV 60
M+ILVTGG GFIGS +R+I+E D EV +D LTY N +L + RY+F + D+
Sbjct: 1 MKILVTGGAGFIGSAVVRHIIENTLD-EVRVMDCLTYAGNLESLAPVAGSERYSFSQTDI 59
Query: 61 ADFELVRELIKKV--DAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIR------- 111
D V + D ++H AAESHVDRSI P F+H+NVIGT+TLLEA R
Sbjct: 60 TDAAAVAAQFSEFRPDIVMHLAAESHVDRSIDGPAAFIHTNVIGTFTLLEAARHYWSGLV 119
Query: 112 -KENPGVRLVHISTDEVYGDILKGSFT---EEDRLMPSSPYSATKAASDMLVLGWARTYG 167
++ R HISTDEVYGD+ + T ++ PSSPYSA+KA SD LV W RTYG
Sbjct: 120 EEQKQAFRFHHISTDEVYGDLHRSQSTCPPKKTSYAPSSPYSASKAGSDHLVRAWNRTYG 179
Query: 168 LNASITRCTNNYGPYQFPEKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRAIEAV 227
L +T C+NNYGPY FPEKLIP TI+ A G +P+YG G+ +RDWLYVE+H RA+ V
Sbjct: 180 LPLVVTNCSNNYGPYHFPEKLIPLTILNALAGKPLPVYGNGEQIRDWLYVEEHARALYKV 239
Query: 228 LLKGEAREIYNISAGEERTNLEVVRTILRIMDK-----------DESLIEFVEDRPGHDI 276
+G++ E YNI ER N++VVRTI I+DK LI FV DRPGHD+
Sbjct: 240 ATEGKSGETYNIGGHNERKNIDVVRTICTILDKVVAQKPGNITHFADLITFVTDRPGHDL 299
Query: 277 RYSLDSWKIIRELKWRPKYRFEEGIKKTVEWYLENEWWWKPLIN 320
RY++D+ KI R+L W P+ FE GI+KTV WYL N+ WW+ +++
Sbjct: 300 RYAIDATKIQRDLGWVPQETFESGIEKTVHWYLNNQTWWQRVLD 343
>gb|AAG09522.1|AF279621_1 (AF279621) dTDP-D-glucose-4,6-dehydratase [Salmonella enterica]
Length = 361
Score = 324 bits (822), Expect = 9e-88
Identities = 171/341 (50%), Positives = 217/341 (63%), Gaps = 28/341 (8%)
Query: 1 MRILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDV 60
M+IL+TGG GFIGS +R+I++ D V+N+DKLTY N +L DI + RY F D+
Sbjct: 1 MKILITGGAGFIGSAVVRHIIKNTQD-TVVNIDKLTYAGNLESLSDISESNRYNFEHADI 59
Query: 61 ADFELVRELIKKV--DAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRK------ 112
D + + ++ DA++H AAESHVDRSI+ P F+ +N++GTY LLE RK
Sbjct: 60 CDSAEIARIFEQYQPDAVMHLAAESHVDRSITGPAAFIETNIVGTYILLEVARKYWSALG 119
Query: 113 --ENPGVRLVHISTDEVYGDI-----LKGS-----FTEEDRLMPSSPYSATKAASDMLVL 160
+ R HISTDEVYGD+ ++ S FTE PSSPYSA+KA+SD LV
Sbjct: 120 EDKKNSFRFHHISTDEVYGDLPHPDEVENSVTLPLFTETTAYAPSSPYSASKASSDHLVR 179
Query: 161 GWARTYGLNASITRCTNNYGPYQFPEKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDH 220
W RTYGL +T C+NNYGPY FPEKLIP I+ A G +PIYG G +RDWLYVEDH
Sbjct: 180 AWRRTYGLPTIVTNCSNNYGPYHFPEKLIPLVILNALEGKSLPIYGKGDQIRDWLYVEDH 239
Query: 221 VRAIEAVLLKGEAREIYNISAGEERTNLEVVRTILRIMD----KDESL---IEFVEDRPG 273
RA+ V+ +GE E YNI E+ NLEVV TI ++D K+ S I +V DRPG
Sbjct: 240 ARALHMVVTQGEVGETYNIGGHNEKKNLEVVHTICDLLDEIVPKEGSYRDQITYVGDRPG 299
Query: 274 HDIRYSLDSWKIIRELKWRPKYRFEEGIKKTVEWYLENEWW 314
HD RY++D+ KI REL W+P FE GI+KTVEWYL N W
Sbjct: 300 HDRRYAIDADKISRELGWKPLETFESGIRKTVEWYLANTQW 340
>pir||H72588 probable dTDP-glucose 4,6-dehydratase APE1180 - Aeropyrum pernix
(strain K1) >gi|5104852|dbj|BAA80166.1| (AP000061) 330aa
long hypothetical dTDP-glucose 4,6-dehydratase
[Aeropyrum pernix]
Length = 330
Score = 324 bits (821), Expect = 1e-87
Identities = 170/334 (50%), Positives = 218/334 (64%), Gaps = 9/334 (2%)
Query: 1 MRILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDV 60
MR+LVTGG GFIGS+F+RYI+ DWEV+ DKLTY NL D+ D R F++GD+
Sbjct: 1 MRVLVTGGAGFIGSSFVRYIVNT-TDWEVLVYDKLTYAGRLENLHDVID--RIGFMRGDI 57
Query: 61 ADFELVRELIKKV--DAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKENPGVR 118
AD E ++ + D +V+FAAE+HVDRSI+ P F+ +N+IG +T+LEAIRK +
Sbjct: 58 ADEEQFGRVLTEFEPDVVVNFAAETHVDRSINEPAPFMRTNIIGVFTILEAIRKRIDQIV 117
Query: 119 LVHISTDEVYGDILKGS--FTEEDRLMPSSPYSATKAASDMLVLGWARTYGLNASITRCT 176
L+H+STDEVYGD+ TE D L PSSPYSA+KA+ D+L+ + RTYGL I R
Sbjct: 118 LLHVSTDEVYGDLWNTGKEATESDPLNPSSPYSASKASGDLLIKAYGRTYGLKYRIVRPC 177
Query: 177 NNYGPYQFPEKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRAIEAVLLKGEAREI 236
NNYGPYQ EKLIP+TIIR G IYG G +RDWLYVED RAI VL KG EI
Sbjct: 178 NNYGPYQHVEKLIPRTIIRILHGKPPVIYGDGSQIRDWLYVEDTARAIHVVLEKGVDGEI 237
Query: 237 YNISAGEERTNLEVVRTILRIMDKDESLIEFVEDRPGHDIRYSLDSWKIIRELKWRPKYR 296
YN+ G T ++V IL M K + + + RPG D RY++ K IR L W P
Sbjct: 238 YNVCGGMASTVKDIVVNILESMGKPRDYLVYGKSRPGEDRRYAMKCDK-IRNLGWAPHVT 296
Query: 297 FEEGIKKTVEWYLENEWWWKPLINER-VLHPTPW 329
+EG+K TV+WY+EN WWW+PL+++R VL PW
Sbjct: 297 LKEGLKITVKWYIENRWWWRPLLDKRYVLADHPW 330
>sp|P44914|RFFG_HAEIN DTDP-GLUCOSE 4,6-DEHYDRATASE >gi|1075419|pir||C64099 dTDPglucose
4,6-dehydratase (EC 4.2.1.46) - Haemophilus influenzae
(strain Rd KW20) >gi|1573891|gb|AAC22531.1| (U32769)
DTDP-glucose 4,6-dehydratase (rffG) [Haemophilus
influenzae Rd]
Length = 338
Score = 323 bits (820), Expect = 1e-87
Identities = 169/334 (50%), Positives = 223/334 (66%), Gaps = 24/334 (7%)
Query: 1 MRILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDV 60
M ILVTGG GFIGS IRYI+ D+ VIN+DKLTY +N + L++++++PRY F K D+
Sbjct: 2 MNILVTGGSGFIGSALIRYIINHTQDF-VINIDKLTYAANQSALREVENNPRYVFEKVDI 60
Query: 61 ADFELVRELIKKV--DAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRK------ 112
D ++ + +K DA++H AAESHVDRSIS +F+ +N++GTYTLLE +
Sbjct: 61 CDLNVIENIFEKYQPDAVMHLAAESHVDRSISGAADFVQTNIVGTYTLLEVAKNYWHTLD 120
Query: 113 --ENPGVRLVHISTDEVYGDIL--KGSFTEEDRLMPSSPYSATKAASDMLVLGWARTYGL 168
+ R HISTDEVYGD+ + +FTE+ PSSPYSA+KAAS+ LV W RTYGL
Sbjct: 121 EAKKTTFRFHHISTDEVYGDLSLSEPAFTEQSPYHPSSPYSASKAASNHLVQAWHRTYGL 180
Query: 169 NASITRCTNNYGPYQFPEKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRAIEAVL 228
IT +NNYG YQ EKLIP I A MG +PIYG G+ +RDWL+VEDHV+A VL
Sbjct: 181 PVIITNSSNNYGAYQHAEKLIPLMISNAVMGKPLPIYGDGQQIRDWLFVEDHVQASYLVL 240
Query: 229 LKGEAREIYNISAGEERTNLEVVRTILRIMDK-----------DESLIEFVEDRPGHDIR 277
KG E YNI E+TNLEVV+ I +++++ E L+ FV+DRPGHD+R
Sbjct: 241 TKGRVGENYNIGGNCEKTNLEVVKRICQLLEELAPSKPNHIKYYEDLMTFVKDRPGHDVR 300
Query: 278 YSLDSWKIIRELKWRPKYRFEEGIKKTVEWYLEN 311
YSLD KI EL W+P+ FE+G+++TV+WYL N
Sbjct: 301 YSLDCSKIHAELGWQPQITFEQGLRQTVKWYLFN 334
>gb|AAD31800.1|AF128273_3 (AF128273) TDP-glucose-4,6-dehydratase homolog [Streptomyces
griseus]
Length = 324
Score = 323 bits (819), Expect = 2e-87
Identities = 163/320 (50%), Positives = 217/320 (66%), Gaps = 7/320 (2%)
Query: 1 MRILVTGGMGFIGSNFIRYILEKHN----DWEVINLDKLTYGSNPANLKDIQDDPRYTFV 56
MRILVTGG GFIGS++ R +L D + LDKLTY + NL D R FV
Sbjct: 1 MRILVTGGAGFIGSHYARSLLAGRYGAAPDTRITVLDKLTYAGDRGNLPAHHD--RLEFV 58
Query: 57 KGDVADFELVRELIKKVDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKENPG 116
+GDV D L+REL+ DAIVHFAAESHVDRS++ F+ +N +GT LLEA
Sbjct: 59 RGDVCDGALLRELLPGHDAIVHFAAESHVDRSVAGGREFVRTNALGTQVLLEAASLSRVE 118
Query: 117 VRLVHISTDEVYGDILKGSFTEEDRLMPSSPYSATKAASDMLVLGWARTYGLNASITRCT 176
R++HISTDEVYG I +GS+TEE L+P+SPY+A+KA++D++ + RT+GL+ SITRC+
Sbjct: 119 -RVLHISTDEVYGSIEQGSWTEERPLLPNSPYAASKASADLIARSYWRTHGLDVSITRCS 177
Query: 177 NNYGPYQFPEKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRAIEAVLLKGEAREI 236
NNYGPYQ PEKL+P+ + G KVP+YG G+N R+W++V+DH RAI VL KG A EI
Sbjct: 178 NNYGPYQHPEKLVPRFVTNLLRGRKVPVYGDGRNRREWIHVDDHCRAIHLVLAKGGAGEI 237
Query: 237 YNISAGEERTNLEVVRTILRIMDKDESLIEFVEDRPGHDIRYSLDSWKIIRELKWRPKYR 296
YN+ +G+E NL + +L + D S+IE+VEDR GHD+RY+LD KI +L + P+
Sbjct: 238 YNVGSGDELENLRLAEHLLALCGADASMIEYVEDRKGHDLRYALDDTKIREQLGYEPQVP 297
Query: 297 FEEGIKKTVEWYLENEWWWK 316
+ GI +TV WY N WW+
Sbjct: 298 LDRGIAETVAWYEANPRWWQ 317
>gb|AAG09509.1|AF279618_1 (AF279618) dTDP-D-glucose-4,6-dehydratase [Salmonella enterica]
Length = 361
Score = 323 bits (818), Expect = 3e-87
Identities = 168/341 (49%), Positives = 216/341 (63%), Gaps = 28/341 (8%)
Query: 1 MRILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDV 60
M+IL+TGG GFIGS +R+I++ D V+N+DKLTY N +L DI + RY F D+
Sbjct: 1 MKILITGGAGFIGSAVVRHIIKNTQD-TVVNIDKLTYAGNLESLSDISESNRYNFEHADI 59
Query: 61 ADFELVRELIKKV--DAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRK------ 112
D + + ++ DA++H AAESHVDRSI+ P F+ +N++GTY LLE RK
Sbjct: 60 CDSAEITRIFEQYQPDAVMHLAAESHVDRSITGPAAFIETNIVGTYVLLEVARKYWSALG 119
Query: 113 --ENPGVRLVHISTDEVYGDI-----LKGS-----FTEEDRLMPSSPYSATKAASDMLVL 160
+ R HISTDEVYGD+ ++ S FTE PSSPYSA+KA+SD LV
Sbjct: 120 EDKKNNFRFHHISTDEVYGDLPHPDEVENSVTLPLFTETTAYAPSSPYSASKASSDHLVR 179
Query: 161 GWARTYGLNASITRCTNNYGPYQFPEKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDH 220
W RTYGL +T C+NNYGPY FPEKLIP I+ A G +PIYG G +RDWLYVEDH
Sbjct: 180 AWRRTYGLPTIVTNCSNNYGPYHFPEKLIPLVILNALEGKPLPIYGKGDQIRDWLYVEDH 239
Query: 221 VRAIEAVLLKGEAREIYNISAGEERTNLEVVRTILRIMDK-------DESLIEFVEDRPG 273
RA+ V+ +G+A E YNI E+ NL+VV TI ++D+ I +V DRPG
Sbjct: 240 ARALHMVVTEGKAGETYNIGGHNEKKNLDVVFTICDLLDEIVPKTTSYREQITYVADRPG 299
Query: 274 HDIRYSLDSWKIIRELKWRPKYRFEEGIKKTVEWYLENEWW 314
HD RY++D+ KI REL W+P FE GI+KTVEWYL N W
Sbjct: 300 HDRRYAIDAGKISRELGWKPLETFESGIRKTVEWYLANTQW 340
>gb|AAC12869.1| (AF044332) dTDP-D-glucose-4,6-dehydratase; RffG [Pectobacterium
carotovorum subsp. atrosepticum]
Length = 357
Score = 323 bits (818), Expect = 3e-87
Identities = 169/338 (50%), Positives = 215/338 (63%), Gaps = 24/338 (7%)
Query: 2 RILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDVA 61
RIL+TGG GFIGS +RYIL + D V+ +DKLTY N ++L + D R+ F + D+
Sbjct: 5 RILITGGAGFIGSALVRYILAETQD-SVVVVDKLTYAGNLSSLAPVADSSRFAFEQVDIC 63
Query: 62 D-FELVRELIKKVDAIV-HFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRK------- 112
D EL R A+V H AAESHVDRSI P F+ +N++GTYT+LEA R
Sbjct: 64 DRAELDRVFTAYQPALVMHLAAESHVDRSIDGPAAFIETNIVGTYTMLEAARHYWQNLAD 123
Query: 113 -ENPGVRLVHISTDEVYGDI--LKGSFTEEDRLMPSSPYSATKAASDMLVLGWARTYGLN 169
+ R HISTDEV+GD+ FTE PSSPYSA+KA+SD LV W RTYG
Sbjct: 124 ADKNAFRFHHISTDEVFGDLHGTDDLFTETTPYAPSSPYSASKASSDHLVRAWLRTYGFP 183
Query: 170 ASITRCTNNYGPYQFPEKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRAIEAVLL 229
IT C+NNYGPY FPEKLIP I+ A G +P+YG G +RDWL+VEDH RA+ V+
Sbjct: 184 TVITNCSNNYGPYHFPEKLIPLVILNAVAGKPLPVYGDGAQIRDWLFVEDHARALYKVVT 243
Query: 230 KGEAREIYNISAGEERTNLEVVRTILRIMDK-----------DESLIEFVEDRPGHDIRY 278
+GE E YNI ER N+EVV+TI ++++ LI +V+DRPGHD+RY
Sbjct: 244 EGEVGETYNIGGHNERKNIEVVQTICALLEELAPNKPAGVAHYRDLITYVKDRPGHDMRY 303
Query: 279 SLDSWKIIRELKWRPKYRFEEGIKKTVEWYLENEWWWK 316
++D+ KI REL WRP+ FE G+KKTV WYL NE WW+
Sbjct: 304 AIDAGKIERELGWRPEETFETGMKKTVSWYLNNEKWWR 341
>sp|P37777|RFBB_SHIFL DTDP-GLUCOSE 4,6-DEHYDRATASE >gi|1073703|pir||B55213 rfbB protein -
Shigella flexneri (strain 2a) >gi|294896|gb|AAA53679.1|
(L14842) dTDP-D-glucose 4,6-dehydratase [Shigella
flexneri]
Length = 361
Score = 323 bits (818), Expect = 3e-87
Identities = 169/341 (49%), Positives = 216/341 (62%), Gaps = 28/341 (8%)
Query: 1 MRILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDV 60
M+ILVTGG GFIGS +R+I+ D V+N+DKLTY N +L D+ D RY F D+
Sbjct: 1 MKILVTGGAGFIGSAVVRHIINNTQD-SVVNVDKLTYAGNLESLADVSDSERYAFEHADI 59
Query: 61 ADFELVRELIKK--VDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIR------- 111
D + + + DA++H AAESHVDRSI+ P F+ +N++GTY LLEA R
Sbjct: 60 CDAVAMSRIFAQHQPDAVMHLAAESHVDRSITGPAAFIETNIVGTYVLLEAARNYWSALN 119
Query: 112 -KENPGVRLVHISTDEVYGDILKGS----------FTEEDRLMPSSPYSATKAASDMLVL 160
++ R HISTDEVYGD+ FTE PSSPYSA+KA+SD LV
Sbjct: 120 DEKKKSFRFHHISTDEVYGDLPHPDEANNNEALPLFTETTAYAPSSPYSASKASSDHLVR 179
Query: 161 GWARTYGLNASITRCTNNYGPYQFPEKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDH 220
W RTYGL +T C+NNYGPY FPEKLIP I+ A G +PIYG G +RDWLYVEDH
Sbjct: 180 AWKRTYGLPTIVTNCSNNYGPYHFPEKLIPLVILNALEGKALPIYGKGDQIRDWLYVEDH 239
Query: 221 VRAIEAVLLKGEAREIYNISAGEERTNLEVVRTILRIMD----KDESL---IEFVEDRPG 273
RA+ V+ +G+A E YNI E+ N++VV TI ++D K++S I +V DRPG
Sbjct: 240 ARALYTVVTEGKAGETYNIGGHNEKKNIDVVLTICDLLDEIVPKEKSYREQITYVADRPG 299
Query: 274 HDIRYSLDSWKIIRELKWRPKYRFEEGIKKTVEWYLENEWW 314
HD RY++D+ KI REL W+P+ FE GI+KTVEWYL N W
Sbjct: 300 HDRRYAIDADKISRELGWKPQETFESGIRKTVEWYLANTNW 340
>sp|P26391|RFBB_SALTY DTDP-GLUCOSE 4,6-DEHYDRATASE >gi|96840|pir||S15299 dTDPglucose
4,6-dehydratase (EC 4.2.1.46) - Salmonella typhimurium
>gi|581654|emb|CAA40115.1| (X56793) dTDP-glucose
4,6-dehydratase [Salmonella enterica]
Length = 361
Score = 323 bits (818), Expect = 3e-87
Identities = 168/341 (49%), Positives = 216/341 (63%), Gaps = 28/341 (8%)
Query: 1 MRILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDV 60
M+IL+TGG GFIGS +R+I++ D V+N+DKLTY N +L DI + RY F D+
Sbjct: 1 MKILITGGAGFIGSAVVRHIIKNTQD-TVVNIDKLTYAGNLESLSDISESNRYNFEHADI 59
Query: 61 ADFELVRELIKKV--DAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRK------ 112
D + + ++ DA++H AAESHVDRSI+ P F+ +N++GTY LLE RK
Sbjct: 60 CDSAEITRIFEQYQPDAVMHLAAESHVDRSITGPAAFIETNIVGTYALLEVARKYWSALG 119
Query: 113 --ENPGVRLVHISTDEVYGDI-----LKGS-----FTEEDRLMPSSPYSATKAASDMLVL 160
+ R HISTDEVYGD+ ++ S FTE PSSPYSA+KA+SD LV
Sbjct: 120 EDKKNNFRFHHISTDEVYGDLPHPDEVENSVTLPLFTETTAYAPSSPYSASKASSDHLVR 179
Query: 161 GWARTYGLNASITRCTNNYGPYQFPEKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDH 220
W RTYGL +T C+NNYGPY FPEKLIP I+ A G +PIYG G +RDWLYVEDH
Sbjct: 180 AWRRTYGLPTIVTNCSNNYGPYHFPEKLIPLVILNALEGKPLPIYGKGDQIRDWLYVEDH 239
Query: 221 VRAIEAVLLKGEAREIYNISAGEERTNLEVVRTILRIMDK-------DESLIEFVEDRPG 273
RA+ V+ +G+A E YNI E+ NL+VV TI ++D+ I +V DRPG
Sbjct: 240 ARALHMVVTEGKAGETYNIGGHNEKKNLDVVFTICDLLDEIVPKATSYREQITYVADRPG 299
Query: 274 HDIRYSLDSWKIIRELKWRPKYRFEEGIKKTVEWYLENEWW 314
HD RY++D+ KI REL W+P FE GI+KTVEWYL N W
Sbjct: 300 HDRRYAIDAGKISRELGWKPLETFESGIRKTVEWYLANTQW 340
>gb|AAC78676.1| (AF094575) dTDP-glucose-4,6-dehydratase Cps19aN [Streptococcus
pneumoniae]
Length = 349
Score = 322 bits (817), Expect = 3e-87
Identities = 161/327 (49%), Positives = 216/327 (65%), Gaps = 16/327 (4%)
Query: 3 ILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDVAD 62
I+VTGG GFIGSNF+ Y+ E D V LDKLTY N AN+++I + R V GD+AD
Sbjct: 7 IIVTGGAGFIGSNFVHYVYENFPDVHVTVLDKLTYAGNRANIEEILGN-RVELVVGDIAD 65
Query: 63 FELVRELIKKVDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKENPGVRLVHI 122
ELV +L + DAIVH+AAESH D S++ P F+H+N IGTYTLLEA RK + +R H+
Sbjct: 66 AELVDKLAAQADAIVHYAAESHNDNSLNDPSPFIHTNFIGTYTLLEAARKYD--IRFHHV 123
Query: 123 STDEVYGDI-----LKG-------SFTEEDRLMPSSPYSATKAASDMLVLGWARTYGLNA 170
STDEVYGD+ L G FT E + PSSPYS+TKAASD++V W R++G+ A
Sbjct: 124 STDEVYGDLPLREDLPGHGEGPGEKFTAETKYNPSSPYSSTKAASDLIVKAWVRSFGVKA 183
Query: 171 SITRCTNNYGPYQFPEKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRAIEAVLLK 230
+I+ C+NNYGPYQ EK IP+ I G+K +YG GKNVRDW++ DH + +L K
Sbjct: 184 TISNCSNNYGPYQHIEKFIPRQITNILSGIKPKLYGEGKNVRDWIHTNDHSSGVWTILTK 243
Query: 231 GEAREIYNISAGEERTNLEVVRTILRIMDKDESLIEFVEDRPGHDIRYSLDSWKIIRELK 290
G+ E Y I A E+ N EV+ IL+ M + + V DR GHD+RY++D+ K+ EL
Sbjct: 244 GQIGETYLIGADGEKNNKEVLELILKEMGQATDAYDHVTDRAGHDLRYAIDASKLREELG 303
Query: 291 WRPKY-RFEEGIKKTVEWYLENEWWWK 316
W+P++ FE G+K T++WY +N+ WWK
Sbjct: 304 WKPEFTNFEAGLKATIKWYTDNQEWWK 330
>gb|AAG09498.1|AF279615_1 (AF279615) dTDP-D-glucose-4,6-dehydratase [Salmonella enterica]
>gi|9957820|gb|AAG09502.1|AF279616_1 (AF279616)
dTDP-D-glucose-4,6-dehydratase [Salmonella enterica]
Length = 361
Score = 322 bits (817), Expect = 3e-87
Identities = 168/341 (49%), Positives = 216/341 (63%), Gaps = 28/341 (8%)
Query: 1 MRILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDV 60
M+IL+TGG GFIGS +R+I++ D V+N+DKLTY N +L DI + RY F D+
Sbjct: 1 MQILITGGAGFIGSAVVRHIIKNTQD-TVVNIDKLTYAGNLESLSDISESNRYNFEHADI 59
Query: 61 ADFELVRELIKKV--DAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRK------ 112
D + + ++ DA++H AAESHVDRSI+ P F+ +N++GTY LLE RK
Sbjct: 60 CDSAEITRIFEQYQPDAVMHLAAESHVDRSITGPAAFIETNIVGTYVLLEVARKYWSALG 119
Query: 113 --ENPGVRLVHISTDEVYGDI-----LKGS-----FTEEDRLMPSSPYSATKAASDMLVL 160
+ R HISTDEVYGD+ ++ S FTE PSSPYSA+KA+SD LV
Sbjct: 120 EDKKNNFRFHHISTDEVYGDLPHPDEVENSVTLPLFTETTAYAPSSPYSASKASSDHLVR 179
Query: 161 GWARTYGLNASITRCTNNYGPYQFPEKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDH 220
W RTYGL +T C+NNYGPY FPEKLIP I+ A G +PIYG G +RDWLYVEDH
Sbjct: 180 AWRRTYGLPTIVTNCSNNYGPYHFPEKLIPLVILNALEGKPLPIYGKGDQIRDWLYVEDH 239
Query: 221 VRAIEAVLLKGEAREIYNISAGEERTNLEVVRTILRIMDK-------DESLIEFVEDRPG 273
RA+ V+ +G+A E YNI E+ NL+VV TI ++D+ I +V DRPG
Sbjct: 240 ARALHMVVTEGKAGETYNIGGHNEKKNLDVVFTICDLLDEIVPKATSYREQITYVADRPG 299
Query: 274 HDIRYSLDSWKIIRELKWRPKYRFEEGIKKTVEWYLENEWW 314
HD RY++D+ KI REL W+P FE GI+KTVEWYL N W
Sbjct: 300 HDRRYAIDAGKISRELGWKPLETFESGIRKTVEWYLANTQW 340
>gb|AAC68681.1| (AF079762) TDP-glucose-4,6-dehydratase [Streptomyces venezuelae]
Length = 337
Score = 322 bits (816), Expect = 4e-87
Identities = 168/322 (52%), Positives = 211/322 (65%), Gaps = 5/322 (1%)
Query: 1 MRILVTGGMGFIGSNFIRYILE-KHNDW---EVINLDKLTYGSNPANLKDIQDDPRYTFV 56
MR+LVTGG GFIGS+F+R +L + D EVI LD LTY N ANL + DPR FV
Sbjct: 1 MRLLVTGGAGFIGSHFVRQLLAGAYPDVPADEVIVLDSLTYAGNRANLAPVDADPRLRFV 60
Query: 57 KGDVADFELVRELIKKVDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKENPG 116
GD+ D L+ ++ VDAIVHFAAESHVDRSI+ F +NV GT TLL+ G
Sbjct: 61 HGDIRDAGLLARELRGVDAIVHFAAESHVDRSIAGASVFTETNVQGTQTLLQCAVDAGVG 120
Query: 117 VRLVHISTDEVYGDILKGSFTEEDRLMPSSPYSATKAASDMLVLGWARTYGLNASITRCT 176
R+VH+STDEVYG I GS+TE L P+SPY+A+KA SD++ + RTYGL+ ITRC
Sbjct: 121 -RVVHVSTDEVYGSIDSGSWTESSPLEPNSPYAASKAGSDLVARAYHRTYGLDVRITRCC 179
Query: 177 NNYGPYQFPEKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRAIEAVLLKGEAREI 236
NNYGPYQ PEKLIP + G +P+YG G NVR+W++ +DH R I VL G A EI
Sbjct: 180 NNYGPYQHPEKLIPLFVTNLLDGGTLPLYGDGANVREWVHTDDHCRGIALVLAGGRAGEI 239
Query: 237 YNISAGEERTNLEVVRTILRIMDKDESLIEFVEDRPGHDIRYSLDSWKIIRELKWRPKYR 296
Y+I G E TN E+ +L + D S + V DR GHD+RYSLD +I REL +RP+
Sbjct: 240 YHIGGGLELTNRELTGILLDSLGADWSSVRKVADRKGHDLRYSLDGGEIERELGYRPQVS 299
Query: 297 FEEGIKKTVEWYLENEWWWKPL 318
F +G+ +TV WY EN WW+PL
Sbjct: 300 FADGLARTVRWYRENRGWWEPL 321
>gb|AAD19915.1| (AF105113) dTDP-glucose-4,6-dehydratase [Streptococcus pneumoniae]
Length = 348
Score = 321 bits (815), Expect = 6e-87
Identities = 159/328 (48%), Positives = 215/328 (65%), Gaps = 16/328 (4%)
Query: 2 RILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDVA 61
+I+VTGG GFIGSNF+ Y+ D V LDKLTY N AN+++I D R V GD+A
Sbjct: 6 KIIVTGGAGFIGSNFVHYVYNNFPDVHVTVLDKLTYAGNRANIEEILGD-RVELVVGDIA 64
Query: 62 DFELVRELIKKVDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKENPGVRLVH 121
D LV +L + DAIVH+AAESH D S++ P F+H+N IGTYTLLEA RK + +R H
Sbjct: 65 DAALVDKLAAEADAIVHYAAESHNDNSLNDPSPFIHTNFIGTYTLLEAARKYD--IRFHH 122
Query: 122 ISTDEVYGDI------------LKGSFTEEDRLMPSSPYSATKAASDMLVLGWARTYGLN 169
+STDEVYGD+ L FT E + PSSPYS+TKAASD++V W R++G+
Sbjct: 123 VSTDEVYGDLPLREDLPGHGEGLGEKFTAETKYNPSSPYSSTKAASDLIVKAWVRSFGVK 182
Query: 170 ASITRCTNNYGPYQFPEKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRAIEAVLL 229
A+I+ C+NNYGPYQ EK IP+ I G+K +YG GKNVRDW++ DH + +L
Sbjct: 183 ATISNCSNNYGPYQHIEKFIPRQITNILSGIKPKLYGEGKNVRDWIHTNDHSSGVWTILT 242
Query: 230 KGEAREIYNISAGEERTNLEVVRTILRIMDKDESLIEFVEDRPGHDIRYSLDSWKIIREL 289
KG+ E Y I A E+ N EV+ IL+ M + + V DR GHD+RY++D+ K+ EL
Sbjct: 243 KGQIGETYLIGADGEKNNKEVLELILKEMGQPADAYDHVTDRAGHDLRYAIDASKLRDEL 302
Query: 290 KWRPKY-RFEEGIKKTVEWYLENEWWWK 316
W+P++ FE G+K+T++WY +N+ WWK
Sbjct: 303 GWKPEFTNFEAGLKETIKWYTDNQDWWK 330
>gb|AAC38674.1| (AF030359) dTDP-glucose-4,6-dehydratase [Streptococcus pneumoniae]
>gi|2804710|gb|AAC38695.1| (AF030363)
dTDP-glucose-4,6-dehydratase [Streptococcus pneumoniae]
>gi|2804723|gb|AAC38706.1| (AF030365)
dTDP-glucose-4,6-dehydratase [Streptococcus pneumoniae]
>gi|2804729|gb|AAC38711.1| (AF030366)
dTDP-glucose-4,6-dehydratase [Streptococcus pneumoniae]
>gi|3320401|gb|AAC38759.1| (AF030373)
dTDP-glucose-4,6-dehydratase [Streptococcus pneumoniae]
>gi|3818498|gb|AAC69540.1| (AF057294) Cps23fQ
[Streptococcus pneumoniae] >gi|4200435|gb|AAD10183.1|
(AF026471) Cps2N [Streptococcus pneumoniae]
Length = 349
Score = 321 bits (815), Expect = 6e-87
Identities = 161/327 (49%), Positives = 216/327 (65%), Gaps = 16/327 (4%)
Query: 3 ILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDVAD 62
I+VTGG GFIGSNF+ Y+ E D V LDKLTY N AN+++I + R V GD+AD
Sbjct: 7 IIVTGGAGFIGSNFVHYVYENFPDVHVTVLDKLTYAGNRANIEEILGN-RVELVVGDIAD 65
Query: 63 FELVRELIKKVDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKENPGVRLVHI 122
ELV +L + DAIVH+AAESH D S++ P F+H+N IGTYTLLEA RK + +R H+
Sbjct: 66 AELVDKLAAQADAIVHYAAESHNDNSLNDPSPFIHTNFIGTYTLLEAARKYD--IRFHHV 123
Query: 123 STDEVYGDI-----LKG-------SFTEEDRLMPSSPYSATKAASDMLVLGWARTYGLNA 170
STDEVYGD+ L G FT E + PSSPYS+TKAASD++V W R++G+ A
Sbjct: 124 STDEVYGDLPLREDLPGHGEGPGEKFTAETKYNPSSPYSSTKAASDLIVKAWVRSFGVKA 183
Query: 171 SITRCTNNYGPYQFPEKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRAIEAVLLK 230
+I+ C+NNYGPYQ EK IP+ I G+K +YG GKNVRDW++ DH + +L K
Sbjct: 184 TISNCSNNYGPYQHIEKFIPRQITNILSGIKPKLYGEGKNVRDWIHTNDHSSGVWTILTK 243
Query: 231 GEAREIYNISAGEERTNLEVVRTILRIMDKDESLIEFVEDRPGHDIRYSLDSWKIIRELK 290
G+ E Y I A E+ N EV+ IL+ M + + V DR GHD+RY++D+ K+ EL
Sbjct: 244 GQIGETYLIGADGEKNNKEVLELILKEMGQAADAYDHVTDRAGHDLRYAIDASKLRDELG 303
Query: 291 WRPKY-RFEEGIKKTVEWYLENEWWWK 316
W+P++ FE G+K T++WY +N+ WWK
Sbjct: 304 WKPEFTNFEAGLKATIKWYTDNQEWWK 330
>pir||G82014 dTDPglucose 4,6-dehydratase (EC 4.2.1.46) NMA0204 [imported] -
Neisseria meningitidis (group B strain MD58, group A
strain Z2491) >gi|4574160|gb|AAD23919.1|AF083467_3
(AF083467) dTDP-D-glucose 4,6-dehydratase [Neisseria
meningitidis] >gi|7378961|emb|CAB83504.1| (AL162752)
dTDP-glucose 4,6-dehydratase [Neisseria meningitidis
Z2491] >gi|7378973|emb|CAB83518.1| (AL162752)
dTDP-glucose 4,6-dehydratase [Neisseria meningitidis
Z2491]
Length = 341
Score = 321 bits (815), Expect = 6e-87
Identities = 169/335 (50%), Positives = 221/335 (65%), Gaps = 26/335 (7%)
Query: 2 RILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDVA 61
+ILVTGG GFIGS +R+I+ D V+NLDKLTY N +L DI D+PRY F + D+
Sbjct: 3 KILVTGGAGFIGSAVVRHIIRNTQD-SVVNLDKLTYAGNLESLTDIADNPRYAFEQVDIC 61
Query: 62 D-FELVRELIK-KVDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIR-------- 111
D EL R + + DA++H AAESHVDRSI S F+ +N++GT+ LLEA R
Sbjct: 62 DRAELDRVFAQHRPDAVMHLAAESHVDRSIGSAGEFIQTNIVGTFNLLEAARAYRQQMPS 121
Query: 112 KENPGVRLVHISTDEVYGDILKGS---FTEEDRLMPSSPYSATKAASDMLVLGWARTYGL 168
+++ R HISTDEVYGD L G+ FTE PSSPYSA+KA+SD LV W RTYGL
Sbjct: 122 EKHEAFRFHHISTDEVYGD-LSGTDDLFTETAPYAPSSPYSASKASSDHLVRAWLRTYGL 180
Query: 169 NASITRCTNNYGPYQFPEKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRAIEAVL 228
+T C+NNYGPY FPEKLIP I+ A G +P+YG G +RDWL+VEDH RA+ V+
Sbjct: 181 PTIVTNCSNNYGPYHFPEKLIPLMILNALDGKPLPVYGDGMQIRDWLFVEDHARALYQVV 240
Query: 229 LKGEAREIYNISAGEERTNLEVVRTILRIMD-----------KDESLIEFVEDRPGHDIR 277
+G E YNI E+ N+EVV+TI +++ + E LI FV+DRPGHD R
Sbjct: 241 TEGVVGETYNIGGHNEKANIEVVKTICALLEELAPEKPAGVARYEDLITFVQDRPGHDAR 300
Query: 278 YSLDSWKIIRELKWRPKYRFEEGIKKTVEWYLENE 312
Y++D+ KI R+L W+P FE G++KTV+WYL+N+
Sbjct: 301 YAVDTAKIRRDLGWQPLETFESGLRKTVQWYLDNK 335
>gb|AAG09534.1|AF279624_1 (AF279624) dTDP-D-glucose-4,6-dehydratase [Salmonella enterica]
Length = 361
Score = 321 bits (815), Expect = 6e-87
Identities = 167/341 (48%), Positives = 213/341 (61%), Gaps = 28/341 (8%)
Query: 1 MRILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDV 60
M+IL+TGG GFIGS +R+I++ D V+N+DKLTY N +L DI + RY F D+
Sbjct: 1 MKILITGGAGFIGSAVVRHIIKNTQD-TVVNIDKLTYAGNLESLSDISESNRYNFEHADI 59
Query: 61 ADFELVRELIKKV--DAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRK------ 112
D + + ++ DA++H AAESHVDRSI+ P F+ +N++GTY LLE RK
Sbjct: 60 CDSAEITRIFEQYQPDAVMHLAAESHVDRSITGPAAFIETNIVGTYVLLEVARKYWSALG 119
Query: 113 --ENPGVRLVHISTDEVYGDILKGS----------FTEEDRLMPSSPYSATKAASDMLVL 160
+ R HISTDEVYGD+ FTE PSSPYSA+KA+SD LV
Sbjct: 120 EDKKNSFRFHHISTDEVYGDLPHPDEVGNSVTLPLFTETTAYAPSSPYSASKASSDHLVR 179
Query: 161 GWARTYGLNASITRCTNNYGPYQFPEKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDH 220
W RTYGL +T C+NNYGPY FPEKLIP I+ A G +PIYG G +RDWLYVEDH
Sbjct: 180 AWRRTYGLPTIVTNCSNNYGPYHFPEKLIPLVILNALEGKSLPIYGKGDQIRDWLYVEDH 239
Query: 221 VRAIEAVLLKGEAREIYNISAGEERTNLEVVRTILRIMDK-------DESLIEFVEDRPG 273
RA+ V+ +G+A E YNI E+ NL+VV TI ++D+ I +V DRPG
Sbjct: 240 ARALYIVVTEGKAGETYNIGGHNEKKNLDVVFTICDLLDEIVPKANSYREQITYVADRPG 299
Query: 274 HDIRYSLDSWKIIRELKWRPKYRFEEGIKKTVEWYLENEWW 314
HD RY++D+ KI REL W+P FE GI+KTVEWYL N W
Sbjct: 300 HDRRYAIDADKISRELGWKPLENFESGIRKTVEWYLANTQW 340
>gb|AAC44971.1| (U09239) dTDP-glucose-4,6-dehydratase [Streptococcus pneumoniae]
Length = 349
Score = 321 bits (814), Expect = 7e-87
Identities = 161/327 (49%), Positives = 216/327 (65%), Gaps = 16/327 (4%)
Query: 3 ILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDVAD 62
I+VTGG GFIGSNF+ Y+ E D V LDKLTY N AN+++I + R V GD+AD
Sbjct: 7 IIVTGGAGFIGSNFVHYVYENFPDVHVTVLDKLTYAGNRANIEEILGN-RVELVVGDIAD 65
Query: 63 FELVRELIKKVDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKENPGVRLVHI 122
ELV +L + DAIVH+AAESH D S++ P F+H+N IGTYTLLEA RK + +R H+
Sbjct: 66 AELVDKLAAQADAIVHYAAESHNDNSLNDPSPFIHTNFIGTYTLLEAARKYD--IRFHHV 123
Query: 123 STDEVYGDI-----LKG-------SFTEEDRLMPSSPYSATKAASDMLVLGWARTYGLNA 170
STDEVYGD+ L G FT E + PSSPYS+TKAASD++V W R++G+ A
Sbjct: 124 STDEVYGDLPLREDLPGHGEGPGEKFTAETKYNPSSPYSSTKAASDLIVKAWVRSFGVKA 183
Query: 171 SITRCTNNYGPYQFPEKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRAIEAVLLK 230
+I+ C+NNYGPYQ EK IP+ I G+K +YG GKNVRDW++ DH + +L K
Sbjct: 184 TISNCSNNYGPYQHIEKFIPRQITNILSGIKPKLYGEGKNVRDWIHTNDHSSGVWIILTK 243
Query: 231 GEAREIYNISAGEERTNLEVVRTILRIMDKDESLIEFVEDRPGHDIRYSLDSWKIIRELK 290
G+ E Y I A E+ N EV+ IL+ M + + V DR GHD+RY++D+ K+ EL
Sbjct: 244 GQIGETYLIGADGEKNNKEVLELILKEMGQAADAYDHVTDRAGHDLRYAIDASKLRDELG 303
Query: 291 WRPKY-RFEEGIKKTVEWYLENEWWWK 316
W+P++ FE G+K T++WY +N+ WWK
Sbjct: 304 WKPEFTNFEAGLKATIKWYTDNQEWWK 330
>gb|AAC38679.1| (AF030360) dTDP-glucose-4,6-dehydratase [Streptococcus pneumoniae]
>gi|2804697|gb|AAC38684.1| (AF030361)
dTDP-glucose-4,6-dehydratase [Streptococcus pneumoniae]
>gi|2804704|gb|AAC38690.1| (AF030362)
dTDP-glucose-4,6-dehydratase [Streptococcus pneumoniae]
>gi|2804716|gb|AAC38700.1| (AF030364)
dTDP-glucose-4,6-dehydratase [Streptococcus pneumoniae]
Length = 349
Score = 321 bits (814), Expect = 7e-87
Identities = 161/327 (49%), Positives = 216/327 (65%), Gaps = 16/327 (4%)
Query: 3 ILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDVAD 62
I+VTGG GFIGSNF+ Y+ E D V LDKLTY N AN+++I + R V GD+AD
Sbjct: 7 IIVTGGAGFIGSNFVHYVYENFPDVHVTVLDKLTYAGNRANIEEILGN-RVELVVGDIAD 65
Query: 63 FELVRELIKKVDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKENPGVRLVHI 122
ELV +L + DAIVH+AAESH D S++ P F+H+N IGTYTLLEA RK + +R H+
Sbjct: 66 AELVDKLAAQADAIVHYAAESHNDNSLNDPSPFIHTNFIGTYTLLEAARKYD--IRFHHV 123
Query: 123 STDEVYGDI-----LKG-------SFTEEDRLMPSSPYSATKAASDMLVLGWARTYGLNA 170
STDEVYGD+ L G FT E + PSSPYS+TKAASD++V W R++G+ A
Sbjct: 124 STDEVYGDLPLREDLLGHGEGPGEKFTAETKYNPSSPYSSTKAASDLIVKAWVRSFGVKA 183
Query: 171 SITRCTNNYGPYQFPEKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRAIEAVLLK 230
+I+ C+NNYGPYQ EK IP+ I G+K +YG GKNVRDW++ DH + +L K
Sbjct: 184 TISNCSNNYGPYQHIEKFIPRQITNILSGIKPKLYGEGKNVRDWIHTNDHSSGVWTILTK 243
Query: 231 GEAREIYNISAGEERTNLEVVRTILRIMDKDESLIEFVEDRPGHDIRYSLDSWKIIRELK 290
G+ E Y I A E+ N EV+ IL+ M + + V DR GHD+RY++D+ K+ EL
Sbjct: 244 GQIGETYLIGADGEKNNKEVLELILKEMGQAADAYDHVTDRAGHDLRYAIDASKLRDELG 303
Query: 291 WRPKY-RFEEGIKKTVEWYLENEWWWK 316
W+P++ FE G+K T++WY +N+ WWK
Sbjct: 304 WKPEFTNFEAGLKATIKWYTDNQEWWK 330
>gb|AAG09506.1|AF279617_1 (AF279617) dTDP-D-glucose-4,6-dehydratase [Salmonella enterica]
Length = 361
Score = 321 bits (814), Expect = 7e-87
Identities = 167/341 (48%), Positives = 213/341 (61%), Gaps = 28/341 (8%)
Query: 1 MRILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDV 60
M+IL+TGG GFIGS +R+I++ D V+N+DKLTY N +L DI + RY F D+
Sbjct: 1 MKILITGGAGFIGSAVVRHIIKNTQD-TVVNIDKLTYAGNLESLSDISESNRYNFEHADI 59
Query: 61 ADFELVRELIKKV--DAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRK------ 112
D + + ++ DA++H AAESHVDRSI+ P F+ +N++GTY LLE RK
Sbjct: 60 CDSAEITRIFEQYQPDAVMHLAAESHVDRSITGPAAFIETNIVGTYVLLEVARKYWSALG 119
Query: 113 --ENPGVRLVHISTDEVYGDILKGS----------FTEEDRLMPSSPYSATKAASDMLVL 160
+ R HISTDEVYGD+ FTE PSSPYSA+KA+SD LV
Sbjct: 120 EDKKNSFRFHHISTDEVYGDLPHPDEAGNSVTLPLFTETTAYAPSSPYSASKASSDHLVR 179
Query: 161 GWARTYGLNASITRCTNNYGPYQFPEKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDH 220
W RTYGL +T C+NNYGPY FPEKLIP I+ A G +PIYG G +RDWLYVEDH
Sbjct: 180 AWRRTYGLPTIVTNCSNNYGPYHFPEKLIPLVILNALEGKSLPIYGKGDQIRDWLYVEDH 239
Query: 221 VRAIEAVLLKGEAREIYNISAGEERTNLEVVRTILRIMDK-------DESLIEFVEDRPG 273
RA+ V+ +G+A E YNI E+ NL+VV TI ++D+ I +V DRPG
Sbjct: 240 ARALYIVVTEGKAGETYNIGGHNEKKNLDVVFTICDLLDEIVPKAASYREQITYVADRPG 299
Query: 274 HDIRYSLDSWKIIRELKWRPKYRFEEGIKKTVEWYLENEWW 314
HD RY++D+ KI REL W+P FE GI+KTVEWYL N W
Sbjct: 300 HDRRYAIDADKISRELGWKPLETFESGIRKTVEWYLANTQW 340
>sp|P37759|RBB1_ECOLI DTDP-GLUCOSE 4,6-DEHYDRATASE >gi|7437240|pir||H64969 dTDPglucose
4,6-dehydratase (EC 4.2.1.46) - Escherichia coli (strain
K-12) >gi|1736731|dbj|BAA15883.1| (D90841) dTDP-glucose
4,6-dehydratase (EC 4.2.1.46). [Escherichia coli]
>gi|1736744|dbj|BAA15895.1| (D90842) dTDP-glucose
4,6-dehydratase (EC 4.2.1.46). [Escherichia coli]
>gi|1788353|gb|AAC75102.1| (AE000294) dTDP-glucose 4,6
dehydratase [Escherichia coli K12]
>gi|2665489|gb|AAB88398.1| (U09876) dTDP-D-glucose
4,6-dehydratase [Escherichia coli]
Length = 361
Score = 321 bits (813), Expect = 1e-86
Identities = 168/341 (49%), Positives = 214/341 (62%), Gaps = 28/341 (8%)
Query: 1 MRILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDV 60
M+ILVTGG GFIGS +R+I+ D V+N+DKLTY N +L D+ D RY F D+
Sbjct: 1 MKILVTGGAGFIGSAVVRHIINNTQD-SVVNVDKLTYAGNRESLADVSDSERYVFEHADI 59
Query: 61 ADFELVRELIKK--VDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRK------ 112
D + + + DA++H AAESHVDRSI+ P F+ +N++GTY LLEA R
Sbjct: 60 CDAPAMARIFAQHQPDAVMHLAAESHVDRSITGPAAFIETNIVGTYVLLEAARNYWSALD 119
Query: 113 --ENPGVRLVHISTDEVYGDILKGS----------FTEEDRLMPSSPYSATKAASDMLVL 160
+ R HISTDEVYGD+ FTE PSSPYSA+KA+SD LV
Sbjct: 120 SDKKNSFRFHHISTDEVYGDLPHPDEVNNTEELPLFTETTAYAPSSPYSASKASSDHLVR 179
Query: 161 GWARTYGLNASITRCTNNYGPYQFPEKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDH 220
W RTYGL +T C+NNYGPY FPEKLIP I+ A G +PIYG G +RDWLYVEDH
Sbjct: 180 AWKRTYGLPTIVTNCSNNYGPYHFPEKLIPLVILNALEGKALPIYGKGDQIRDWLYVEDH 239
Query: 221 VRAIEAVLLKGEAREIYNISAGEERTNLEVVRTILRIMD----KDESL---IEFVEDRPG 273
RA+ V+ +G+A E YNI E+ N++VV TI ++D K++S I +V DRPG
Sbjct: 240 ARALYTVVTEGKAGETYNIGGHNEKKNIDVVLTICDLLDEIVPKEKSYREQITYVADRPG 299
Query: 274 HDIRYSLDSWKIIRELKWRPKYRFEEGIKKTVEWYLENEWW 314
HD RY++D+ KI R L W+P+ FE GI+KTVEWYL N W
Sbjct: 300 HDRRYAIDAEKIGRALGWKPQETFESGIRKTVEWYLSNTKW 340
>emb|CAB05932.1| (Z83335) dTDP-glucose 4,6-dehydratase [Streptococcus pneumoniae]
Length = 349
Score = 321 bits (813), Expect = 1e-86
Identities = 160/327 (48%), Positives = 216/327 (65%), Gaps = 16/327 (4%)
Query: 3 ILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDVAD 62
I+VTGG GFIGSNF+ Y+ E D V LDKLTY N AN+++I + R V GD+AD
Sbjct: 7 IIVTGGAGFIGSNFVHYVYENFPDVHVTVLDKLTYAGNRANIEEILGN-RVELVVGDIAD 65
Query: 63 FELVRELIKKVDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKENPGVRLVHI 122
ELV +L+ + DAIVH+AAESH D S++ P F+H+N IG YTLLEA RK + +R H+
Sbjct: 66 AELVDKLVAQADAIVHYAAESHNDNSLNDPSPFIHTNFIGIYTLLEAARKYD--IRFHHV 123
Query: 123 STDEVYGDI-----LKG-------SFTEEDRLMPSSPYSATKAASDMLVLGWARTYGLNA 170
STDEVYGD+ L G FT E + PSSPYS+TKAASD++V W R++G+ A
Sbjct: 124 STDEVYGDLPLREDLPGHGEGPGEKFTAETKYNPSSPYSSTKAASDLIVKAWVRSFGVKA 183
Query: 171 SITRCTNNYGPYQFPEKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRAIEAVLLK 230
+I+ C+NNYGPYQ EK IP+ I G+K +YG GKNVRDW++ DH + +L K
Sbjct: 184 TISNCSNNYGPYQHIEKFIPRQITNILSGIKPKLYGEGKNVRDWIHTNDHSSGVWTILTK 243
Query: 231 GEAREIYNISAGEERTNLEVVRTILRIMDKDESLIEFVEDRPGHDIRYSLDSWKIIRELK 290
G+ E Y I A E+ N EV+ IL+ M + + V DR GHD+RY++D+ K+ EL
Sbjct: 244 GQIGETYLIGADGEKNNKEVLELILKEMGQATDAYDHVTDRAGHDLRYAIDASKLRDELG 303
Query: 291 WRPKY-RFEEGIKKTVEWYLENEWWWK 316
W+P++ FE G+K T++WY +N+ WWK
Sbjct: 304 WKPEFTNFEAGLKATIKWYTDNQEWWK 330
>gb|AAG09537.1|AF279625_1 (AF279625) dTDP-D-glucose-4,6-dehydratase [Salmonella enterica]
Length = 361
Score = 321 bits (813), Expect = 1e-86
Identities = 166/341 (48%), Positives = 213/341 (61%), Gaps = 28/341 (8%)
Query: 1 MRILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDV 60
M+IL+TGG GFIGS +R+I++ D V+N+DKLTY N +L DI + RY F D+
Sbjct: 1 MKILITGGAGFIGSAVVRHIIKNTQD-TVVNIDKLTYAGNLESLSDISESNRYNFEHADI 59
Query: 61 ADFELVRELIKKV--DAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRK------ 112
D + + ++ DA++H AAESHVDRSI+ P F+ +N++GTY LLE RK
Sbjct: 60 CDSAEITRIFEQYQPDAVMHLAAESHVDRSITGPAAFIETNIVGTYVLLEGARKYWSALG 119
Query: 113 --ENPGVRLVHISTDEVYGDILKGS----------FTEEDRLMPSSPYSATKAASDMLVL 160
+ R HISTDEVYGD+ FTE PSSPYSA+KA+SD LV
Sbjct: 120 EDKKNSFRFHHISTDEVYGDLPHPDEAENSVTLPLFTETTAYAPSSPYSASKASSDHLVR 179
Query: 161 GWARTYGLNASITRCTNNYGPYQFPEKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDH 220
W RTYGL +T C+NNYGPY FPEKLIP I+ A G +PIYG G +RDWLYVEDH
Sbjct: 180 AWRRTYGLPTIVTNCSNNYGPYHFPEKLIPLVILNALEGKPLPIYGKGDQIRDWLYVEDH 239
Query: 221 VRAIEAVLLKGEAREIYNISAGEERTNLEVVRTILRIMDK-------DESLIEFVEDRPG 273
RA+ V+ +G+A E YNI E+ NL+VV TI ++D+ I +V DRPG
Sbjct: 240 ARALHMVVTEGKAGETYNIGGHNEKKNLDVVFTICDLLDEIVPKATSYREQITYVADRPG 299
Query: 274 HDIRYSLDSWKIIRELKWRPKYRFEEGIKKTVEWYLENEWW 314
HD RY++D+ KI RE+ W+P FE GI+KTVEWYL N W
Sbjct: 300 HDRRYAIDADKISREIGWKPLETFESGIRKTVEWYLANTQW 340
>sp|P27830|RFFG_ECOLI DTDP-GLUCOSE 4,6-DEHYDRATASE >gi|7437241|pir||G65182 dTDPglucose
4,6-dehydratase (EC 4.2.1.46) - Escherichia coli (strain
K-12) >gi|6729763|pdb|1BXK|B Chain B, Dtdp-Glucose
4,6-Dehydratase From E. Coli >gi|6729762|pdb|1BXK|A
Chain A, Dtdp-Glucose 4,6-Dehydratase From E. Coli
>gi|1790223|gb|AAC76793.1| (AE000455) dTDP-glucose
4,6-dehydratase [Escherichia coli K12]
Length = 355
Score = 320 bits (812), Expect = 1e-86
Identities = 168/338 (49%), Positives = 213/338 (62%), Gaps = 24/338 (7%)
Query: 2 RILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDVA 61
+IL+TGG GFIGS +RYI+ + +D V+ +DKLTY N +L + R+ F K D+
Sbjct: 3 KILITGGAGFIGSALVRYIINETSD-AVVVVDKLTYAGNLMSLAPVAQSERFAFEKVDIC 61
Query: 62 D-FELVRELIK-KVDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRK------- 112
D EL R + + D ++H AAESHVDRSI P F+ +N++GTYTLLEA R
Sbjct: 62 DRAELARVFTEHQPDCVMHLAAESHVDRSIDGPAAFIETNIVGTYTLLEAARAYWNALTE 121
Query: 113 -ENPGVRLVHISTDEVYGDILKGS--FTEEDRLMPSSPYSATKAASDMLVLGWARTYGLN 169
+ R HISTDEVYGD+ FTE PSSPYSA+KA+SD LV W RTYGL
Sbjct: 122 DKKSAFRFHHISTDEVYGDLHSTDDFFTETTPYAPSSPYSASKASSDHLVRAWLRTYGLP 181
Query: 170 ASITRCTNNYGPYQFPEKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRAIEAVLL 229
IT C+NNYGPY FPEKLIP I+ A G +P+YG G+ +RDWLYVEDH RA+ V
Sbjct: 182 TLITNCSNNYGPYHFPEKLIPLMILNALAGKSLPVYGNGQQIRDWLYVEDHARALYCVAT 241
Query: 230 KGEAREIYNISAGEERTNLEVVRTILRIMDK-----------DESLIEFVEDRPGHDIRY 278
G+ E YNI ER NL+VV TI ++++ LI FV DRPGHD+RY
Sbjct: 242 TGKVGETYNIGGHNERKNLDVVETICELLEELAPNKPHGVAHYRDLITFVADRPGHDLRY 301
Query: 279 SLDSWKIIRELKWRPKYRFEEGIKKTVEWYLENEWWWK 316
++D+ KI REL P+ FE G++KTV+WYL NE WWK
Sbjct: 302 AIDASKIARELGCVPQETFESGMRKTVQWYLANESWWK 339
>gb|AAG09530.1|AF279623_1 (AF279623) dTDP-D-glucose-4,6-dehydratase [Salmonella enterica]
Length = 361
Score = 320 bits (812), Expect = 1e-86
Identities = 167/341 (48%), Positives = 213/341 (61%), Gaps = 28/341 (8%)
Query: 1 MRILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDV 60
M+IL+TGG GFIGS +R+I+ K+ V+N+DKLTY N +L DI + RY F D+
Sbjct: 1 MKILITGGAGFIGSAVVRHII-KNTQNTVVNIDKLTYAGNLESLSDISESNRYNFEHADI 59
Query: 61 ADFELVRELIKKV--DAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRK------ 112
D + + ++ DA++H AAESHVDRSI+ P F+ +N++GTY LLE RK
Sbjct: 60 CDSAAITRIFEQYQPDAVMHLAAESHVDRSITGPAAFIETNIVGTYVLLEVARKYWSALG 119
Query: 113 --ENPGVRLVHISTDEVYGDILKGS----------FTEEDRLMPSSPYSATKAASDMLVL 160
+ R HISTDEVYGD+ FTE PSSPYSA+KA+SD LV
Sbjct: 120 EDKKNSFRFHHISTDEVYGDLPHPDEAGNSVTLPLFTETTAYAPSSPYSASKASSDHLVR 179
Query: 161 GWARTYGLNASITRCTNNYGPYQFPEKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDH 220
W RTYGL +T C+NNYGPY FPEKLIP I+ A G +PIYG G +RDWLYVEDH
Sbjct: 180 AWRRTYGLPTIVTNCSNNYGPYHFPEKLIPLVILNALEGKSLPIYGKGDQIRDWLYVEDH 239
Query: 221 VRAIEAVLLKGEAREIYNISAGEERTNLEVVRTILRIMDK-------DESLIEFVEDRPG 273
RA+ V+ +G+A E YNI E+ NL+VV TI ++D+ I +V DRPG
Sbjct: 240 ARALYIVVTEGKAGETYNIGGHNEKKNLDVVFTICDLLDEIVPKATSYREQITYVADRPG 299
Query: 274 HDIRYSLDSWKIIRELKWRPKYRFEEGIKKTVEWYLENEWW 314
HD RY++D+ KI REL W+P FE GI+KTVEWYL N W
Sbjct: 300 HDRRYAIDADKISRELGWKPLETFESGIRKTVEWYLANTKW 340
>gb|AAG29802.1| (AF235050) dTDP-glucose 4,6-dehydratase [Streptomyces rishiriensis]
Length = 336
Score = 320 bits (811), Expect = 2e-86
Identities = 163/324 (50%), Positives = 208/324 (63%), Gaps = 5/324 (1%)
Query: 1 MRILVTGGMGFIGSNFIRY----ILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFV 56
MR+LVTGG GFIGS F+R +L + ++ LDKLTY N NL I D Y FV
Sbjct: 1 MRLLVTGGAGFIGSEFVRATLRGVLPGSSGTQITVLDKLTYSGNELNLAPIADLETYRFV 60
Query: 57 KGDVADFELVRELIKKVDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKENPG 116
+GD+ D LV +++ DAIVHFAAE+HVDRSI +F+ +N +GT LLEA + G
Sbjct: 61 QGDICDRGLVDDVVAGHDAIVHFAAETHVDRSIEGAASFVRTNALGTQVLLEAASRHRLG 120
Query: 117 VRLVHISTDEVYGDILKGSFTEEDRLMPSSPYSATKAASDMLVLGWARTYGLNASITRCT 176
R VHISTDEVYG I +G++TE + P++PY+A KAA D+L L W RT L+ +TRCT
Sbjct: 121 -RFVHISTDEVYGSISEGAWTEASPVAPNAPYAAAKAAGDLLALAWHRTRKLDVVVTRCT 179
Query: 177 NNYGPYQFPEKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRAIEAVLLKGEAREI 236
NNYGPYQ+PEKLIP G +VP+YG G N R WL+V DH RAI+ VLL G E+
Sbjct: 180 NNYGPYQYPEKLIPLFTTNLLDGQQVPVYGDGHNRRQWLHVSDHCRAIQCVLLGGRPGEV 239
Query: 237 YNISAGEERTNLEVVRTILRIMDKDESLIEFVEDRPGHDIRYSLDSWKIIRELKWRPKYR 296
Y+I G E TNLE+ IL + V DR GHD+RYSLD+ KI EL + P+
Sbjct: 240 YHIGGGTELTNLELTEHILEACGAGWDRVRHVPDRLGHDLRYSLDTTKIRTELGYSPRVA 299
Query: 297 FEEGIKKTVEWYLENEWWWKPLIN 320
F +G+ +TVEWY + WW+PL N
Sbjct: 300 FADGLAETVEWYRTHRGWWEPLKN 323
>pir||S75783 dTDPglucose 4,6-dehydratase (EC 4.2.1.46) - Synechocystis sp.
(strain PCC 6803) >gi|1001273|dbj|BAA10518.1| (D64003)
dTDP-glucose 4,6-dehydratase [Synechocystis sp.]
Length = 342
Score = 319 bits (810), Expect = 2e-86
Identities = 161/336 (47%), Positives = 217/336 (63%), Gaps = 19/336 (5%)
Query: 3 ILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDVAD 62
ILVTGG GFIG+NF+ + ++ D ++ LD LTY N A L ++ P + FV+GD+ D
Sbjct: 6 ILVTGGAGFIGANFVYHCVQTCGDRRIVVLDALTYAGNRATLAPLEKLPNFRFVQGDIGD 65
Query: 63 FELVRELIKK--VDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKE-----NP 115
LV +L+++ ++ I HFAAESHVDRSI P F+ +NV+GT+TLLEA R+ NP
Sbjct: 66 RHLVDQLLREEQIETIAHFAAESHVDRSILGPGAFVQTNVVGTFTLLEAFREHWQRRGNP 125
Query: 116 G-VRLVHISTDEVYGDILKGS--FTEEDRLMPSSPYSATKAASDMLVLGWARTYGLNASI 172
R +H+STDEVYG + F+E P+SPYSA+KA SD LV + TYGL I
Sbjct: 126 AQFRFLHVSTDEVYGSLTPNEPGFSETTPYSPNSPYSASKAGSDHLVRAYFHTYGLPTLI 185
Query: 173 TRCTNNYGPYQFPEKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRAIEAVLLKGE 232
T C+NNYGPYQFPEKLIP + G K+P+YG G+NVRDWLYV DH +A++ VL +
Sbjct: 186 TNCSNNYGPYQFPEKLIPLMCLNILRGEKLPVYGDGQNVRDWLYVTDHCQALDLVLHQAL 245
Query: 233 AREIYNISAGEERTNLEVVRTILRIMDK---------DESLIEFVEDRPGHDIRYSLDSW 283
YNI E N+E+V + +MD+ LI +V DRPGHD RY++D+
Sbjct: 246 PGATYNIGGNNEVKNIELVEILCDLMDELAPDLPVKPARQLISYVTDRPGHDRRYAIDAS 305
Query: 284 KIIRELKWRPKYRFEEGIKKTVEWYLENEWWWKPLI 319
KI REL W PK E G+++TV+WYL++E WW+PL+
Sbjct: 306 KIKRELGWEPKVTVERGLRQTVQWYLDHEAWWRPLL 341
>pir||B83000 dTDP-D-glucose 4,6-dehydratase PA5161 [imported] - Pseudomonas
aeruginosa (strain PAO1)
>gi|9951463|gb|AAG08546.1|AE004929_1 (AE004929)
dTDP-D-glucose 4,6-dehydratase [Pseudomonas aeruginosa]
Length = 352
Score = 319 bits (810), Expect = 2e-86
Identities = 163/335 (48%), Positives = 218/335 (64%), Gaps = 22/335 (6%)
Query: 1 MRILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDV 60
M ILVTG GFIG+NF+ L H++ V++LDKLTY N NL + D R+TFV GD+
Sbjct: 1 MTILVTGSAGFIGANFVLDWLALHDE-PVVSLDKLTYAGNRQNLASLDGDARHTFVAGDI 59
Query: 61 ADFELVRELIKKVD--AIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIR------- 111
D +LV L+ + AI++FAAESHVDRSI P++F+ +N++GT+ LLE +R
Sbjct: 60 GDSQLVARLLAEHQPRAILNFAAESHVDRSIHGPEDFIQTNIVGTFRLLEEVRAYWGALE 119
Query: 112 -KENPGVRLVHISTDEVYGDILKG--SFTEEDRLMPSSPYSATKAASDMLVLGWARTYGL 168
+ R +H+STDEVYG + +FTE +R P+SPYSA+KAASD LV + TYGL
Sbjct: 120 PEAKAAFRFLHVSTDEVYGSLAPSDPAFTENNRYEPNSPYSASKAASDHLVRAYHHTYGL 179
Query: 169 NASITRCTNNYGPYQFPEKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRAIEAVL 228
T C+NNYGPY FPEKLIP I A G +PIYG G+ +RDWLYV+DH AI VL
Sbjct: 180 PVLTTNCSNNYGPYHFPEKLIPLVIHNALAGKPLPIYGDGQQIRDWLYVKDHCSAIRRVL 239
Query: 229 LKGEAREIYNISAGEERTNLEVVRTILRIMDKDE---------SLIEFVEDRPGHDIRYS 279
G+ E YN+ E+ NL+VV T+ I+D+++ I FV+DRPGHD RY+
Sbjct: 240 EAGQLGETYNVGGWNEKANLDVVETLCAILDQEQPRADGRSYREQITFVKDRPGHDRRYA 299
Query: 280 LDSWKIIRELKWRPKYRFEEGIKKTVEWYLENEWW 314
+D+ ++ REL W+P FE GI+KTV WYL+N+ W
Sbjct: 300 IDATRLERELGWKPAETFETGIRKTVRWYLDNQDW 334
>gb|AAG35060.1|AF314183_2 (AF314183) dTDP-glucose-4,6-dehydratase [Agrobacterium tumefaciens]
Length = 351
Score = 319 bits (810), Expect = 2e-86
Identities = 159/336 (47%), Positives = 220/336 (65%), Gaps = 19/336 (5%)
Query: 1 MRILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDV 60
MR+LVTGG GFIGS +RY++ + +V+ +DKLTY N A+LK I++ P + F++ D+
Sbjct: 1 MRVLVTGGAGFIGSALVRYLVSEVGA-DVLTVDKLTYAGNLASLKPIENAPNHRFLQADI 59
Query: 61 ADFELVRELIK--KVDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRK------ 112
D + + + D ++H AAESHVDRSI+ +F+ +N+ GT+T+LEA R+
Sbjct: 60 CDRAAMNDAFATFQPDYVMHLAAESHVDRSITGAADFIQTNINGTFTMLEAARQYWSSLA 119
Query: 113 --ENPGVRLVHISTDEVYGDILK-GSFTEEDRLMPSSPYSATKAASDMLVLGWARTYGLN 169
R++H+STDEVYG + G F E PSSPYSA+KAASD L W RTYGL
Sbjct: 120 DDAKANFRMLHVSTDEVYGSLGDDGLFEETTPYDPSSPYSASKAASDHLATAWQRTYGLP 179
Query: 170 ASITRCTNNYGPYQFPEKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRAIEAVLL 229
I+ C+NNYGP+ FPEKLIP I+ A G +P+YG G N+RDWLYVEDH RA+ ++
Sbjct: 180 FVISNCSNNYGPFHFPEKLIPLIILNALEGKPLPVYGNGANIRDWLYVEDHARALWLIVQ 239
Query: 230 KGEAREIYNISAGEERTNLEVVRTILRIMDK-------DESLIEFVEDRPGHDIRYSLDS 282
KG A E YN+ E+ N++VV I I+D+ +LI++V DRPGHD RY++D+
Sbjct: 240 KGLAGEKYNVGGRNEQKNIDVVNCICSILDELRPQSKPYANLIQYVTDRPGHDARYAIDA 299
Query: 283 WKIIRELKWRPKYRFEEGIKKTVEWYLENEWWWKPL 318
K+ EL W+ + F GI+KTVEWYL+N WWW+PL
Sbjct: 300 TKLETELGWKAQENFATGIRKTVEWYLDNAWWWQPL 335
>sp|P55462|RFBB_RHISN PROBABLE DTDP-GLUCOSE 4,6-DEHYDRATASE >gi|2182408|gb|AAB91680.1|
(AE000074) Y4gF [Rhizobium sp. NGR234]
Length = 350
Score = 319 bits (809), Expect = 3e-86
Identities = 159/336 (47%), Positives = 218/336 (64%), Gaps = 20/336 (5%)
Query: 1 MRILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDV 60
MRILVTGG GFIGS +RY++ + EV+N+DKLTY N A+LK ++ Y F++ D+
Sbjct: 1 MRILVTGGAGFIGSALVRYLVSINA--EVLNVDKLTYAGNLASLKPVEGLRNYRFLRADI 58
Query: 61 ADFELVRELIK--KVDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRK------ 112
D + E + + D ++H AAESHVDRSI+ D+F+ +NV GT+T+LE R+
Sbjct: 59 CDRVAINEAFETFQPDYVIHLAAESHVDRSITGADDFVQTNVNGTFTMLETARQYWSNLS 118
Query: 113 --ENPGVRLVHISTDEVYGDIL-KGSFTEEDRLMPSSPYSATKAASDMLVLGWARTYGLN 169
+++H+STDEVYG + +G F E PSSPYSA+KAASD W RTYGL
Sbjct: 119 QNRKAFFKMLHVSTDEVYGSLGDRGQFEEVSPYDPSSPYSASKAASDHFATAWQRTYGLP 178
Query: 170 ASITRCTNNYGPYQFPEKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRAIEAVLL 229
I+ C+NNYGP+ FPEKLIP I+ A +P+YGTG N+RDWLYV+DH RA+ ++
Sbjct: 179 VVISNCSNNYGPFHFPEKLIPLMILNALDRKPLPVYGTGSNIRDWLYVDDHARALWLIVR 238
Query: 230 KGEAREIYNISAGEERTNLEVVRTILRIMDKDE-------SLIEFVEDRPGHDIRYSLDS 282
+G E YN+ E N++VV I ++D+ LI FV+DRPGHD RY++D+
Sbjct: 239 EGRPGEKYNVGGRNELRNIDVVNRICLLLDELSPNASHYGDLITFVKDRPGHDARYAIDA 298
Query: 283 WKIIRELKWRPKYRFEEGIKKTVEWYLENEWWWKPL 318
K+ EL W+ + F+ GI+KTVEWYLEN WWW+PL
Sbjct: 299 TKLETELGWKAQENFDTGIRKTVEWYLENGWWWQPL 334
>sp|P55293|RBB2_ECOLI DTDP-GLUCOSE 4,6-DEHYDRATASE >gi|7437235|pir||S78542 dTDPglucose
4,6-dehydratase (EC 4.2.1.46) - Escherichia coli (strain
VW187) >gi|799232|gb|AAC63612.1| (AF125322) RmlB
[Escherichia coli]
Length = 361
Score = 319 bits (808), Expect = 4e-86
Identities = 170/341 (49%), Positives = 217/341 (62%), Gaps = 28/341 (8%)
Query: 1 MRILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDV 60
M+ILVTGG GFIGS +R+I+ D V+N+DKLTY N +L +I D RY+F D+
Sbjct: 1 MKILVTGGAGFIGSAVVRHIINNTQD-SVVNVDKLTYAGNLESLAEISDSERYSFENADI 59
Query: 61 ADFELVRELI--KKVDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKENPGV- 117
D E ++DA++H AAESHVDRSI+ P F+ +N++GTY LLEA R G+
Sbjct: 60 CDAEGDGLYFGQHQLDAVMHLAAESHVDRSITGPAAFIETNIVGTYVLLEAARNYWSGLD 119
Query: 118 -------RLVHISTDEVYGDILKGS----------FTEEDRLMPSSPYSATKAASDMLVL 160
R HISTDEVYGD+ FTE PSSPYSA+KA+SD LV
Sbjct: 120 DEKKKNFRFHHISTDEVYGDLPHPDEVNSNETLQLFTETTAYAPSSPYSASKASSDHLVR 179
Query: 161 GWARTYGLNASITRCTNNYGPYQFPEKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDH 220
W RTYGL ++ C+NNYGPY FPEKLIP I+ A G +PIYG G +RDWLYVEDH
Sbjct: 180 AWKRTYGLPTIVSNCSNNYGPYHFPEKLIPLVILNALEGKALPIYGKGDQIRDWLYVEDH 239
Query: 221 VRAIEAVLLKGEAREIYNISAGEERTNLEVVRTILRIMD----KDESL---IEFVEDRPG 273
RA+ V+ +G+A E YNI E+ N++VV TI ++D K++S I +V DRPG
Sbjct: 240 ARALYTVVTEGKAGETYNIGGHNEKKNIDVVFTICDLLDEIVPKEKSYREQITYVADRPG 299
Query: 274 HDIRYSLDSWKIIRELKWRPKYRFEEGIKKTVEWYLENEWW 314
HD RY++D+ KI REL W+P+ FE GI+KTVEWYL N W
Sbjct: 300 HDRRYAIDADKISRELGWKPQETFESGIRKTVEWYLANTNW 340
>pir||I55054 dTDP-D-glucose 4,6-dehydratase - Escherichia coli
Length = 361
Score = 319 bits (808), Expect = 4e-86
Identities = 170/342 (49%), Positives = 215/342 (62%), Gaps = 30/342 (8%)
Query: 1 MRILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDV 60
M+ILVTGG GFIGS +R+I+ D V+N+DKLTY N +L D+ D RY F D+
Sbjct: 1 MKILVTGGAGFIGSAVVRHIINNTQD-SVVNVDKLTYAGNRESLADVSDSERYVFEHADI 59
Query: 61 ADFELVRELIKK--VDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIR------- 111
D + + + DA++H AAESHVDRSI+ P F+ +N++GTY LLEA R
Sbjct: 60 CDAPAMARIFAQHQPDAVMHLAAESHVDRSITGPAAFIETNIVGTYVLLEAARNYWSALD 119
Query: 112 --KENPGVRLVHISTDEVYGDILKGS----------FTEEDRLMPSSPYSATKAASDMLV 159
KEN R HISTDEVYGD+ FTE PSSPYSA+KA+SD LV
Sbjct: 120 SDKEN-SFRFHHISTDEVYGDLPHPDEVNNTEELPLFTETTAYAPSSPYSASKASSDHLV 178
Query: 160 LGWARTYGLNASITRCTNNYGPYQFPEKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVED 219
W RTYGL +T C+NNYGPY FPEKLIP I+ A G +PIYG G +RDWLYVED
Sbjct: 179 RAWKRTYGLPTIVTNCSNNYGPYHFPEKLIPLVILNALEGKALPIYGKGDQIRDWLYVED 238
Query: 220 HVRAIEAVLLKGEAREIYNISAGEERTNLEVVRTILRIMD----KDESL---IEFVEDRP 272
H RA+ V+ + +A E YNI E+ N++VV TI ++D K++S I +V DRP
Sbjct: 239 HARALYTVVTEVKAGETYNIGGHNEKKNIDVVLTICDLLDEIVPKEKSYREQITYVADRP 298
Query: 273 GHDIRYSLDSWKIIRELKWRPKYRFEEGIKKTVEWYLENEWW 314
GHD RY++D+ KI R L W+P+ FE GI+KTVEWYL N W
Sbjct: 299 GHDRRYAIDAEKIGRALGWKPQETFESGIRKTVEWYLSNTKW 340
>gb|AAG09517.1|AF279620_1 (AF279620) dTDP-D-glucose-4,6-dehydratase [Salmonella enterica]
Length = 361
Score = 319 bits (808), Expect = 4e-86
Identities = 167/341 (48%), Positives = 216/341 (62%), Gaps = 28/341 (8%)
Query: 1 MRILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDV 60
M+IL+TGG GFIGS IR+I++ D V+N+DKLTY N +L DI + RY F D+
Sbjct: 1 MKILITGGAGFIGSAVIRHIIKNTQD-TVVNIDKLTYAGNLESLSDISESNRYNFEHADI 59
Query: 61 ADFELVRELIKKV--DAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRK------ 112
D + + ++ DA++H AAESHVDRSI+ P F+ +N++GTY LLE RK
Sbjct: 60 CDSAEITRIFEQYQPDAVMHLAAESHVDRSITGPAAFIETNIVGTYVLLEVARKYWSALG 119
Query: 113 --ENPGVRLVHISTDEVYGDI-----LKGS-----FTEEDRLMPSSPYSATKAASDMLVL 160
+ R HISTDEVYGD+ ++ S FTE PSSPYSA+KA+SD LV
Sbjct: 120 EDKKNSFRFHHISTDEVYGDLPHPDEVENSVTLPLFTETTAYAPSSPYSASKASSDHLVR 179
Query: 161 GWARTYGLNASITRCTNNYGPYQFPEKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDH 220
W RTYGL +T C+NNYGPY FPEKLIP I+ A G +PIYG G +RDWLYVED+
Sbjct: 180 AWRRTYGLPTIVTNCSNNYGPYHFPEKLIPLVILNALEGKPLPIYGKGDQIRDWLYVEDY 239
Query: 221 VRAIEAVLLKGEAREIYNISAGEERTNLEVVRTILRIMDK-------DESLIEFVEDRPG 273
RA+ V+ +G+A E YNI E+ N++VV TI ++D+ I +V DRPG
Sbjct: 240 ARALYIVVTEGKAGETYNIGGHNEKKNVDVVFTICDLLDEIVPKAASYREQITYVADRPG 299
Query: 274 HDIRYSLDSWKIIRELKWRPKYRFEEGIKKTVEWYLENEWW 314
HD RY++D+ KI REL W+P FE GI+KTVEWYL N W
Sbjct: 300 HDRRYAIDAGKISRELGWKPLETFESGIRKTVEWYLANTQW 340
>pir||S30682 hypothetical protein o355 - Escherichia coli
>gi|148191|gb|AAA67588.1| (M87049) possibly rffE;
(UDP-GlcNAc-2-epimerase) [Escherichia coli]
Length = 355
Score = 318 bits (807), Expect = 5e-86
Identities = 167/338 (49%), Positives = 212/338 (62%), Gaps = 24/338 (7%)
Query: 2 RILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDVA 61
+IL+TGG GFIGS +RYI+ + +D V+ +DKLTY N +L + R+ F K D+
Sbjct: 3 KILITGGAGFIGSALVRYIINETSD-AVVVVDKLTYAGNLMSLAPVAQSERFAFEKVDIC 61
Query: 62 D-FELVRELIK-KVDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRK------- 112
D EL R + + D ++H AAESHVDRSI P F+ +N++GTYTLLEA R
Sbjct: 62 DRAELARVFTEHQPDCVMHLAAESHVDRSIDGPAAFIETNIVGTYTLLEAARAYWNALTE 121
Query: 113 -ENPGVRLVHISTDEVYGDILKGS--FTEEDRLMPSSPYSATKAASDMLVLGWARTYGLN 169
+ R HISTDEVYGD+ FTE PSSPYSA+KA+SD LV W RTYGL
Sbjct: 122 DKKSAFRFHHISTDEVYGDLHSTDDFFTETTPYAPSSPYSASKASSDHLVRAWLRTYGLP 181
Query: 170 ASITRCTNNYGPYQFPEKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRAIEAVLL 229
IT C+NNYGPY FPEKLIP I+ A G +P+YG G+ +RDWLYVEDH RA+ V
Sbjct: 182 TLITNCSNNYGPYHFPEKLIPLMILNALAGKSLPVYGNGQQIRDWLYVEDHARALYCVAT 241
Query: 230 KGEAREIYNISAGEERTNLEVVRTILRIMDK-----------DESLIEFVEDRPGHDIRY 278
G+ E YNI ER NL+VV TI ++++ LI FV DRPGHD+RY
Sbjct: 242 TGKVGETYNIGGHNERKNLDVVETICELLEELAPNKPHGVAHYRDLITFVADRPGHDLRY 301
Query: 279 SLDSWKIIRELKWRPKYRFEEGIKKTVEWYLENEWWWK 316
++D+ KI REL P+ FE G++K V+WYL NE WWK
Sbjct: 302 AIDASKIARELGCVPQETFESGMRKXVQWYLANESWWK 339
>gb|AAG09526.1|AF279622_1 (AF279622) dTDP-D-glucose-4,6-dehydratase [Salmonella enterica]
Length = 361
Score = 318 bits (807), Expect = 5e-86
Identities = 167/341 (48%), Positives = 212/341 (61%), Gaps = 28/341 (8%)
Query: 1 MRILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDV 60
M+IL+TGG GFIGS +R+I++ D V+N+DKLTY N +L DI RY F D+
Sbjct: 1 MKILITGGAGFIGSAVVRHIIKNTQD-TVVNIDKLTYAGNLESLCDISKSNRYNFEHADI 59
Query: 61 ADFELVRELIKKV--DAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRK------ 112
D + + ++ DA++H AAESHVDRSI+ P F+ +N++GTY LLE RK
Sbjct: 60 CDSAEITRIFEQYQPDAVMHLAAESHVDRSITGPAAFIETNIVGTYVLLEVARKYWSALG 119
Query: 113 --ENPGVRLVHISTDEVYGDILKGS----------FTEEDRLMPSSPYSATKAASDMLVL 160
+ R HISTDEVYGD+ FTE PSSPYSA+KA+SD LV
Sbjct: 120 EDKKNSFRFHHISTDEVYGDLPHPDEVGNSVTLPLFTETTAYAPSSPYSASKASSDHLVR 179
Query: 161 GWARTYGLNASITRCTNNYGPYQFPEKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDH 220
W RTYGL +T C+NNYGPY FPEKLIP I+ A G +PIYG G +RDWLYVEDH
Sbjct: 180 AWRRTYGLPTIVTNCSNNYGPYHFPEKLIPLVILNALEGKSLPIYGKGDQIRDWLYVEDH 239
Query: 221 VRAIEAVLLKGEAREIYNISAGEERTNLEVVRTILRIMDK-------DESLIEFVEDRPG 273
RA+ V+ +G+A E YNI E+ NL+VV TI ++D+ I +V DRPG
Sbjct: 240 ARALYIVVTEGKAGETYNIGGHNEKKNLDVVFTICDLLDEIVPKATSYREQITYVADRPG 299
Query: 274 HDIRYSLDSWKIIRELKWRPKYRFEEGIKKTVEWYLENEWW 314
HD RY++D+ KI REL W+P FE GI+KTVEWYL N W
Sbjct: 300 HDRRYAIDADKISRELGWKPLETFESGIRKTVEWYLANTKW 340
>gb|AAC35922.1| (AF071085) putative dTDP-glucose-4,6-dehydratase [Enterococcus
faecalis]
Length = 342
Score = 317 bits (805), Expect = 8e-86
Identities = 159/328 (48%), Positives = 210/328 (63%), Gaps = 16/328 (4%)
Query: 2 RILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDVA 61
+I+VTGG GFIGSNF+ Y+++ H + V LDKLTY N NL+ I D R V GD+
Sbjct: 3 KIIVTGGAGFIGSNFVHYVVKNHPEVHVTVLDKLTYAGNEKNLEGIPSD-RVELVVGDIV 61
Query: 62 DFELVRELIKKVDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKENPGVRLVH 121
D ELV L+ + DA+VH+A ESH D S++ P F+ +N+IGTYTL+EA RK N VR H
Sbjct: 62 DAELVNRLVAETDAVVHYAXESHNDNSLNDPFPFVQTNLIGTYTLIEACRKNN--VRYHH 119
Query: 122 ISTDEVYGDI-----LKG-------SFTEEDRLMPSSPYSATKAASDMLVLGWARTYGLN 169
+STDEVYGD+ L G FT E PSSPYS+TKA SD+LV W R++ L
Sbjct: 120 VSTDEVYGDLPLREDLPGHGEGEGEKFTAETPYNPSSPYSSTKAGSDLLVKAWVRSFNLQ 179
Query: 170 ASITRCTNNYGPYQFPEKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRAIEAVLL 229
A+I+ C+NNYGPYQ EK IP+ I G+ +YG GKNVRDW++ DH A+ A+L
Sbjct: 180 ATISNCSNNYGPYQHIEKFIPRQITNVLSGITPKLYGAGKNVRDWIHTNDHSSAVWAILT 239
Query: 230 KGEAREIYNISAGEERTNLEVVRTILRIMDKDESLIEFVEDRPGHDIRYSLDSWKIIREL 289
KG+ E Y I A E N V+ IL +M + E V DR GHD+RY++DS ++ EL
Sbjct: 240 KGQIGETYLIGADGEEDNKTVMELILELMGQPVDAYEHVNDRVGHDLRYAIDSTRLREEL 299
Query: 290 KWRPKY-RFEEGIKKTVEWYLENEWWWK 316
W P++ F EG+ +T++WY ENE WW+
Sbjct: 300 GWEPEFTNFREGLAETIKWYTENEDWWR 327
>gb|AAB66647.1| (U43540) rhamnose biosynthesis protein [Mycobacterium tuberculosis]
>gi|2326950|gb|AAB66648.1| (U43540) rfbA gene product
[Mycobacterium tuberculosis]
Length = 329
Score = 317 bits (803), Expect = 1e-85
Identities = 159/318 (50%), Positives = 217/318 (68%), Gaps = 9/318 (2%)
Query: 1 MRILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDV 60
MR+LVTGG GFIG+NF+ + +H D V LD LTY +L D++D R V+GD+
Sbjct: 1 MRLLVTGGAGFIGTNFVHSAVREHPDDAVTVLDALTYAGRRESLADVEDAIR--LVQGDI 58
Query: 61 ADFELVRELIKKVDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKENPGVRLV 120
D ELV +L+ + DA+VHFAAESHVD ++ +P+ FLH+NVIGT+T+LEA+R+ GVRL
Sbjct: 59 TDAELVSQLVAESDAVVHFAAESHVDNALDNPEPFLHTNVIGTFTILEAVRRH--GVRLH 116
Query: 121 HISTDEVYGDIL---KGSFTEEDRLMPSSPYSATKAASDMLVLGWARTYGLNASITRCTN 177
HISTDEVYGD+ + FTE PSSPYSATKA +DMLV W R+ + A+I+ C+N
Sbjct: 117 HISTDEVYGDLELDDRARFTESTPYNPSSPYSATKAGADMLVRAWVRSLCVRATISNCSN 176
Query: 178 NYGPYQFPEKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRAIEAVLLKGEAREIY 237
NYGPYQ EK IP+ I GL + +YG G NVRDW++V+DH A+ +L +G E Y
Sbjct: 177 NYGPYQHVEKFIPRQITNCLTGL-LKLYGDGGNVRDWIHVDDHNSAVRRILDRGRIGETY 235
Query: 238 NISAGEERTNLEVVRTILRIMDKDESLIEFVEDRPGHDIRYSLDSWKIIRELKWRPKYR- 296
IS+ ER NL V+R++LR+MD+D + V DR HD+RY++D ++ EL W PK+
Sbjct: 236 LISSEGERDNLTVLRSLLRLMDRDPDDFDHVTDRVAHDLRYAIDPSRLYDELCWAPKHTD 295
Query: 297 FEEGIKKTVEWYLENEWW 314
FE ++ T++WY +NE W
Sbjct: 296 FERALRTTIDWYRDNESW 313
>sp|P37761|RFBB_NEIGO DTDP-GLUCOSE 4,6-DEHYDRATASE >gi|628590|pir||S47045 dTDPglucose
4,6-dehydratase (EC 4.2.1.46) - Neisseria gonorrhoeae
>gi|520896|emb|CAA83652.1| (Z32742) dTDP-D-glucose
4,6-dehydratase [Neisseria gonorrhoeae]
>gi|1333793|emb|CAA79718.1| (Z21508) dTDP-D-glucose
4,6-dehydratase [Neisseria gonorrhoeae]
Length = 346
Score = 316 bits (801), Expect = 2e-85
Identities = 166/333 (49%), Positives = 218/333 (64%), Gaps = 24/333 (7%)
Query: 3 ILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDVAD 62
ILVTGG GFIGS +R+I++ D V+NLDKLTY N +L DI D+PRY F + D+ D
Sbjct: 9 ILVTGGAGFIGSAVVRHIIQNTRD-SVVNLDKLTYAGNLESLTDIADNPRYAFEQVDICD 67
Query: 63 -FELVRELIK-KVDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIR--------K 112
EL R + + DA++H AAESHVDR+I S F+ +N++GT+ LLEA R +
Sbjct: 68 RAELDRVFAQYRPDAVMHLAAESHVDRAIGSAGEFIRTNIVGTFDLLEAARAYWQQMPSE 127
Query: 113 ENPGVRLVHISTDEVYGDI--LKGSFTEEDRLMPSSPYSATKAASDMLVLGWARTYGLNA 170
+ R HISTDEVYGD+ FTE PSSPYSA+KAA+D LV W RTY L +
Sbjct: 128 KREAFRFHHISTDEVYGDLHGTDDLFTETTPYAPSSPYSASKAAADHLVRAWQRTYRLPS 187
Query: 171 SITRCTNNYGPYQFPEKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRAIEAVLLK 230
++ C+NNYGP QFPEKLIP I+ A G +P+YG G +RDWL+VEDH RA+ V+ +
Sbjct: 188 IVSNCSNNYGPRQFPEKLIPLMILNALSGKPLPVYGDGAQIRDWLFVEDHARALYQVVTE 247
Query: 231 GEAREIYNISAGEERTNLEVVRTILRIMD-----------KDESLIEFVEDRPGHDIRYS 279
G E YNI E+TNLEVV+TI +++ + E LI FV+DRPGHD RY+
Sbjct: 248 GVVGETYNIGGHNEKTNLEVVKTICALLEELAPEKPAGVARYEDLITFVQDRPGHDARYA 307
Query: 280 LDSWKIIRELKWRPKYRFEEGIKKTVEWYLENE 312
+D+ KI R+L W P FE G++KTV+WYL+N+
Sbjct: 308 VDAAKIRRDLGWLPLETFESGLRKTVQWYLDNK 340
>emb|CAB39839.1| (AL049491) putative dTDP-(glucose or rhamnose)-4,6-dehydratase
[Mycobacterium leprae]
Length = 331
Score = 316 bits (800), Expect = 3e-85
Identities = 156/322 (48%), Positives = 212/322 (65%), Gaps = 8/322 (2%)
Query: 1 MRILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDV 60
MR+LVTGG GFIG+NF+ + H D V LD +TY +L D+ D V+G++
Sbjct: 1 MRLLVTGGAGFIGANFVHNAVRDHPDDTVTVLDAMTYAGRHESLADV--DHAVRLVQGNI 58
Query: 61 ADFELVRELIKKVDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKENPGVRLV 120
D +LV L+ + D +VHFAAE+HVD ++ P+ FL +NVIGT+T+LEA+R + VRL
Sbjct: 59 TDTKLVFRLVAESDVVVHFAAETHVDNALDDPEPFLRTNVIGTFTILEAVRHHS--VRLH 116
Query: 121 HISTDEVYGDILKGS---FTEEDRLMPSSPYSATKAASDMLVLGWARTYGLNASITRCTN 177
HISTDEVYGD+ FTE PSSPYSATKAA DMLV W R+YG+ A+I+ C+N
Sbjct: 117 HISTDEVYGDLELDEPTRFTESTPYNPSSPYSATKAAGDMLVRAWVRSYGVRATISNCSN 176
Query: 178 NYGPYQFPEKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRAIEAVLLKGEAREIY 237
NYGPYQ EK IP+ I G + +YGTG NVRDW++V+DH A+ +L KG+ Y
Sbjct: 177 NYGPYQHVEKFIPRQITNVLTGRRPKLYGTGVNVRDWIHVDDHNSAVWQILEKGQIGRTY 236
Query: 238 NISAGEERTNLEVVRTILRIMDKDESLIEFVEDRPGHDIRYSLDSWKIIRELKWRPKY-R 296
I A NL V+RT+L++M +D + + V DR GHD+RY++D + EL W PK+
Sbjct: 237 LIGAENGHNNLTVLRTLLQMMGRDPNDFDHVTDRVGHDLRYAIDPTPLYNELCWAPKHAN 296
Query: 297 FEEGIKKTVEWYLENEWWWKPL 318
F+EG++ T++WY NE WW+PL
Sbjct: 297 FDEGLRATIDWYRNNESWWRPL 318
>gb|AAD31797.1|AF128272_2 (AF128272) TDP-glucose-4,6-dehydratase [Streptomyces spectabilis]
Length = 330
Score = 315 bits (798), Expect = 6e-85
Identities = 159/321 (49%), Positives = 208/321 (64%), Gaps = 4/321 (1%)
Query: 1 MRILVTGGMGFIGSNFIRYIL---EKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVK 57
MRI+VTGG GFIGS F+R +L ND + LDKLTY NL + PR+ FV
Sbjct: 1 MRIIVTGGAGFIGSEFVRSMLLAPGAANDIRITVLDKLTYAGVRENLDPVAGHPRHAFVH 60
Query: 58 GDVADFELVRELIKKVDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKENPGV 117
GD+ D + + +++ DA+VHFAAE+HVDRSI+ F+ +NV+GT LL+A R+ G
Sbjct: 61 GDICDGDFLDQVVPGHDAVVHFAAETHVDRSITGSAPFVTTNVLGTQLLLDAARRHGVG- 119
Query: 118 RLVHISTDEVYGDILKGSFTEEDRLMPSSPYSATKAASDMLVLGWARTYGLNASITRCTN 177
R +H+STDEVYG I GS++EE L P+SPY+ATKA S++L L RT+G++ +TRC+N
Sbjct: 120 RFLHVSTDEVYGSIPVGSWSEESPLAPNSPYAATKAGSELLALACHRTHGMDVVVTRCSN 179
Query: 178 NYGPYQFPEKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRAIEAVLLKGEAREIY 237
NYGPYQFPEK+IP I R G KVP+YG G++VRDWL+V DH R +E L G A E+Y
Sbjct: 180 NYGPYQFPEKVIPLFITRLLDGGKVPLYGDGQHVRDWLHVSDHCRGVELALRHGRAGEVY 239
Query: 238 NISAGEERTNLEVVRTILRIMDKDESLIEFVEDRPGHDIRYSLDSWKIIRELKWRPKYRF 297
+I G E TN ++ +L + +E V DR GHD RYSLD K EL + P F
Sbjct: 240 HIGGGTELTNEQLTGHLLAATGRGWEQVERVPDRKGHDARYSLDCTKAATELGYAPLVGF 299
Query: 298 EEGIKKTVEWYLENEWWWKPL 318
E G+ TV WY N WW+PL
Sbjct: 300 ERGLADTVAWYAGNRSWWEPL 320
>gb|AAG09513.1|AF279619_1 (AF279619) dTDP-D-glucose-4,6-dehydratase [Salmonella enterica]
Length = 361
Score = 314 bits (796), Expect = 1e-84
Identities = 166/342 (48%), Positives = 216/342 (62%), Gaps = 30/342 (8%)
Query: 1 MRILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDV 60
M+ILVTGG GFIGS +R+I++ D V+N+DKLTY N +L ++ + RY F D+
Sbjct: 1 MKILVTGGAGFIGSAVVRHIIKDTQD-TVVNVDKLTYAGNLESLTEVSESHRYHFEHADI 59
Query: 61 ADFELVRELI--KKVDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIR------- 111
D + + + DA++H AAESHVDRSI+ P F+ +N++GTY LLEA R
Sbjct: 60 CDKAAMERIFVTHQPDAVMHLAAESHVDRSITGPAAFIETNIVGTYVLLEAARSYWNALD 119
Query: 112 -KENPGVRLVHISTDEVYGD------ILKGS----FTEEDRLMPSSPYSATKAASDMLVL 160
++ R HISTDEVYGD + GS FTE+ PSSPYSA+KA+SD LV
Sbjct: 120 VEKKAAFRFHHISTDEVYGDLPHPDEVSAGSVLPLFTEKTAYAPSSPYSASKASSDHLVR 179
Query: 161 GWARTYGLNASITRCTNNYGPYQFPEKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDH 220
W RTYG +T C+NNYGPY FPEKLIP I+ A G +PIYG G +RDWLYVEDH
Sbjct: 180 AWLRTYGFPTIVTNCSNNYGPYHFPEKLIPLVILNALEGKALPIYGKGDQIRDWLYVEDH 239
Query: 221 VRAIEAVLLKGEAREIYNISAGEERTNLEVVRTILRIMDK--------DESLIEFVEDRP 272
RA+ V+ +G E YNI E+ NL+VV+TI ++D+ + LI +V DRP
Sbjct: 240 ARALYTVVTQGVVGETYNIGGHNEKKNLDVVQTICDLLDEIVPKEGAYRDQLI-YVTDRP 298
Query: 273 GHDIRYSLDSWKIIRELKWRPKYRFEEGIKKTVEWYLENEWW 314
GHD RY++D+ KI EL W+P+ FE GI+KTVEWYL N W
Sbjct: 299 GHDRRYAIDAAKISDELGWKPQETFESGIRKTVEWYLNNTQW 340
>pir||C75597 thymidine diphosphoglucose 4,6-dehydratase - Deinococcus
radiodurans (strain R1)
>gi|6460562|gb|AAF12268.1|AE001862_94 (AE001862)
thymidine diphosphoglucose 4,6-dehydratase [Deinococcus
radiodurans]
Length = 364
Score = 313 bits (794), Expect = 2e-84
Identities = 158/319 (49%), Positives = 211/319 (65%), Gaps = 6/319 (1%)
Query: 3 ILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDVAD 62
+LVTGG GFIGSNF+RY L +H + +V+ DKLTY NL D+ D+P + V GD+ D
Sbjct: 16 LLVTGGCGFIGSNFVRYWLGQHPESKVVVYDKLTYAGRKENLHDLWDNPALSLVVGDIGD 75
Query: 63 FELVRELIKK--VDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKENPGVRLV 120
+LVR ++ VD IV+FAAE+HVD+SI P F +NV GT+ LLE R+ G+RL
Sbjct: 76 MDLVRRTCQENDVDLIVNFAAETHVDQSILGPLVFTETNVRGTHVLLEVAREL--GIRLH 133
Query: 121 HISTDEVYGDILKG-SFTEEDRLMPSSPYSATKAASDMLVLGWARTYGLNASITRCTNNY 179
HISTDEVYG I G E D L P SPY+A+KAA+D LV +A TYG+ +ITR NN
Sbjct: 134 HISTDEVYGHIKDGHQSVETDELAPRSPYAASKAAADQLVQAYAITYGIPVTITRGANNV 193
Query: 180 GPYQFPEKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRAIEAVLLKGEAREIYNI 239
GPYQ+PEK +P A +G +P+YG G+ +RD+ +V DH IE VLL+G E+YN+
Sbjct: 194 GPYQYPEKAVPLFSTNAILGEPLPVYGDGQQMRDYAHVYDHCTGIETVLLRGNIGEVYNV 253
Query: 240 SAGEERTNLEVVRTILRIMDKDESLIEFVEDRPGHDIRYSLDSWKIIRELKWRPKYRFEE 299
G E TNLE+V +L + KD SL++ V DRPGHD RYS++ K +R L W+PKY ++
Sbjct: 254 GTGREMTNLEMVDIVLETLGKDHSLVKHVTDRPGHDRRYSMNVDK-LRSLGWQPKYDPKQ 312
Query: 300 GIKKTVEWYLENEWWWKPL 318
+ + WY N WWW+P+
Sbjct: 313 AVAEAARWYEGNRWWWEPI 331
>gb|AAF00211.1|AF164960_7 (AF164960) dNDP-glucose 4,6-dehydratase [Streptomyces fradiae]
Length = 328
Score = 313 bits (793), Expect = 2e-84
Identities = 161/323 (49%), Positives = 215/323 (65%), Gaps = 9/323 (2%)
Query: 1 MRILVTGGMGFIGSNFIRYIL-EKHNDWE---VINLDKLTYGSNPANLKDIQDDPRYTFV 56
M ILVTG GFIGS+F+R +L + ++ WE V LDKLTY N NL +PR FV
Sbjct: 1 MNILVTGAAGFIGSHFVRSLLADTYSGWEGARVTALDKLTYAGNRNNLPP--SNPRLEFV 58
Query: 57 KGDVADFELVRELIKKVDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKENPG 116
+GDV D L+REL+ A+VHFAAESHVDRS+ F +NV+GT TLL+A+ + G
Sbjct: 59 RGDVCDRALLRELLPGHHAVVHFAAESHVDRSLEGAGEFFRTNVLGTQTLLDAVL--DSG 116
Query: 117 V-RLVHISTDEVYGDILKGSFTEEDRLMPSSPYSATKAASDMLVLGWARTYGLNASITRC 175
V R+VH+STDEVYG I +GS+TE+ L P+SPY+A+KA SD++ + ++ SITRC
Sbjct: 117 VERVVHVSTDEVYGSIEQGSWTEDWPLQPNSPYAASKACSDLVARAYCAPTEVDLSITRC 176
Query: 176 TNNYGPYQFPEKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRAIEAVLLKGEARE 235
+NNYGP+Q PEK+IP+ + G +VP+YG G+NVR+WL+VEDH R I VL KG+A E
Sbjct: 177 SNNYGPHQHPEKVIPRFVTNLLEGRQVPLYGDGRNVREWLHVEDHCRGIHLVLNKGQAGE 236
Query: 236 IYNISAGEERTNLEVVRTILRIMDKDESLIEFVEDRPGHDIRYSLDSWKIIRELKWRPKY 295
IYNI G E TNL + +L + +I V DR HD+RYS+D KI +L + P+
Sbjct: 237 IYNIGGGNEYTNLALTEKLLELTGAGPEMIRRVPDRKAHDLRYSIDESKIREKLGYAPRI 296
Query: 296 RFEEGIKKTVEWYLENEWWWKPL 318
FE+G+ TV WY +N WWK +
Sbjct: 297 SFEQGLSDTVAWYRDNPDWWKSI 319
>pir||S41534 dTDPglucose 4,6-dehydratase (EC 4.2.1.46) - Shigella flexneri
>gi|581659|emb|CAA50767.1| (X71970) rfbB [Shigella
flexneri]
Length = 361
Score = 312 bits (792), Expect = 3e-84
Identities = 164/341 (48%), Positives = 213/341 (62%), Gaps = 28/341 (8%)
Query: 1 MRILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDV 60
M+I VTGG GFIGS +R+I+ D V+N+DKLTY N +L D+ D RY F D+
Sbjct: 1 MKIPVTGGAGFIGSAVVRHIINNTQD-SVVNVDKLTYAGNLESLADVSDSERYAFEHADI 59
Query: 61 ADFELVRELIKKVDA--IVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIR------- 111
D + + + A ++H AAESHVDRSI+ P F+ +N++GTY LLEA R
Sbjct: 60 CDAVAMSRIFRTAPARRVMHLAAESHVDRSITGPAAFIETNIVGTYVLLEAARNYWSALN 119
Query: 112 -KENPGVRLVHISTDEVYGDILKGS----------FTEEDRLMPSSPYSATKAASDMLVL 160
++ R HISTDEVYGD+ FTE +SPYSA+KA++D LV
Sbjct: 120 DEKKKSFRFHHISTDEVYGDLPHPDEANNNETLPLFTETTTKRQNSPYSASKASNDHLVR 179
Query: 161 GWARTYGLNASITRCTNNYGPYQFPEKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDH 220
W RTYGL +T C+NNYGPY FPEKLIP I+ A G +PIYG G +RDWLYVEDH
Sbjct: 180 AWKRTYGLPTIVTNCSNNYGPYHFPEKLIPLVILNALEGKALPIYGKGDQIRDWLYVEDH 239
Query: 221 VRAIEAVLLKGEAREIYNISAGEERTNLEVVRTILRIMD----KDESL---IEFVEDRPG 273
RA+ V+ +G+A E YNI E+ N++VV TI ++D K++S I +V DRPG
Sbjct: 240 ARALYTVVTEGKAGETYNIGGHNEKKNIDVVLTICDLLDEIVPKEKSYREQITYVADRPG 299
Query: 274 HDIRYSLDSWKIIRELKWRPKYRFEEGIKKTVEWYLENEWW 314
HD RY++D+ KI REL W+P+ FE GI+KTVEWYL N W
Sbjct: 300 HDRRYAIDADKISRELGWKPQETFESGIRKTVEWYLANTNW 340
>dbj|BAA84593.1| (AB032523) dTDP-glucose 4,6-dehydratase [Streptomyces avermitilis]
Length = 355
Score = 312 bits (792), Expect = 3e-84
Identities = 161/318 (50%), Positives = 210/318 (65%), Gaps = 5/318 (1%)
Query: 5 VTGGMGFIGSNFIRYILE----KHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDV 60
+TGG GFIGS+F+R +L EV+ LDKLTY NL + P FV GD+
Sbjct: 1 MTGGAGFIGSHFVRRLLTGAYPAFTGAEVVVLDKLTYAGRLENLAPVLGSPSLIFVHGDI 60
Query: 61 ADFELVRELIKKVDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKENPGVRLV 120
D LV +L+ D +VHFAAESHVDRS++ F+ +NV+GT+TLL A R V
Sbjct: 61 CDGPLVADLMDGSDMVVHFAAESHVDRSVADAAEFVRTNVLGTHTLLRAATDAAVD-RFV 119
Query: 121 HISTDEVYGDILKGSFTEEDRLMPSSPYSATKAASDMLVLGWARTYGLNASITRCTNNYG 180
+ISTDEVYG I GS+TE+ L P+SPYSA+KA+SD+L + RT+GL ITRC+NNYG
Sbjct: 120 YISTDEVYGSIDSGSWTEDAPLEPNSPYSASKASSDLLARSFHRTHGLPVIITRCSNNYG 179
Query: 181 PYQFPEKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRAIEAVLLKGEAREIYNIS 240
P+QFPEKLIP+ + G KVP+YG G+NVRDWL+V+DH R I V +G EIY+I
Sbjct: 180 PHQFPEKLIPRFVTHLLNGTKVPLYGDGENVRDWLHVDDHCRGIALVAERGRPGEIYHIG 239
Query: 241 AGEERTNLEVVRTILRIMDKDESLIEFVEDRPGHDIRYSLDSWKIIRELKWRPKYRFEEG 300
G E +N E+ +L ++ D S++E V DR GHD RYSLD KI EL + P+ FEEG
Sbjct: 240 GGTELSNRELTARLLDLLGVDWSMVEPVTDRKGHDRRYSLDISKISAELGYAPRVPFEEG 299
Query: 301 IKKTVEWYLENEWWWKPL 318
+ +TV+WY+EN W+PL
Sbjct: 300 LAQTVQWYVENRTLWEPL 317
>pir||S49054 dTDPglucose 4,6-dehydratase (EC 4.2.1.46) [similarity] -
Streptomyces fradiae (strain T59235)
>gi|473600|gb|AAA21344.1| (U08223) dTDP-glucose
dehydratase [Streptomyces fradiae]
Length = 333
Score = 312 bits (791), Expect = 4e-84
Identities = 161/322 (50%), Positives = 204/322 (63%), Gaps = 5/322 (1%)
Query: 1 MRILVTGGMGFIGSNFIRYILEKH----NDWEVINLDKLTYGSNPANLKDIQDDPRYTFV 56
MR+LVTGG GFIGS+F +L + LDKLTY NPANL+ + P FV
Sbjct: 1 MRVLVTGGAGFIGSHFTGQLLTGAYPDLGATRTVVLDKLTYAGNPANLEHVAGHPDLEFV 60
Query: 57 KGDVADFELVRELIKKVDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKENPG 116
+GD+AD R L++ V +VHFAAESHVDRSI S + F+ +NV GT LL+A G
Sbjct: 61 RGDIADHGWWRRLMEGVGLVVHFAAESHVDRSIESSEAFVRTNVEGTRVLLQAAVDAGVG 120
Query: 117 VRLVHISTDEVYGDILKGSFTEEDRLMPSSPYSATKAASDMLVLGWARTYGLNASITRCT 176
R VHISTDEVYG I +GS+ E+ + P+SPY+ATKAASD+L L + RTYGL+ +TRC+
Sbjct: 121 -RFVHISTDEVYGSIAEGSWPEDHPVAPNSPYAATKAASDLLALAYHRTYGLDVRVTRCS 179
Query: 177 NNYGPYQFPEKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRAIEAVLLKGEAREI 236
NNYGP Q+PEK +P GL VP+YG G N R+WL+V+DH R + V G I
Sbjct: 180 NNYGPRQYPEKAVPLFTTNLLDGLPVPLYGDGGNTREWLHVDDHCRGVALVGAGGRPGVI 239
Query: 237 YNISAGEERTNLEVVRTILRIMDKDESLIEFVEDRPGHDIRYSLDSWKIIRELKWRPKYR 296
YNI G E TN E+ IL + D S + V DRPGHD RYS+D+ KI EL + P+
Sbjct: 240 YNIGGGTELTNAELTDRILELCGADRSALRRVADRPGHDRRYSVDTTKIREELGYAPRTG 299
Query: 297 FEEGIKKTVEWYLENEWWWKPL 318
EG+ TV WY +N WW+PL
Sbjct: 300 ITEGLAGTVAWYRDNRAWWEPL 321
>emb|CAA77209.1| (Y18523) dTDP-glucose 4,6-dehydratase [Actinoplanes sp. 50/110]
Length = 341
Score = 310 bits (785), Expect = 2e-83
Identities = 154/320 (48%), Positives = 208/320 (64%), Gaps = 6/320 (1%)
Query: 1 MRILVTGGMGFIGSNFIRYILE-----KHNDWEVINLDKLTYGSNPANLKDIQDDPRYTF 55
M+ILVTGG GFIGS+F+ ++ +V +DKL YG N NL + DPR++F
Sbjct: 1 MKILVTGGAGFIGSHFVTSLISGDIATPQPVTQVTVVDKLGYGGNLRNLAEASADPRFSF 60
Query: 56 VKGDVADFELVRELIKKVDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKENP 115
V+GD+ D L+ L+ + D + HFAAE+HVDRS+ + F+ SN++GT LL+A + +
Sbjct: 61 VRGDICDEGLIEGLMARHDTVAHFAAETHVDRSVVASGPFVASNLVGTQVLLDAALRHHI 120
Query: 116 GVRLVHISTDEVYGDILKGSFTEEDRLMPSSPYSATKAASDMLVLGWARTYGLNASITRC 175
G R +H+STDEVYG I GS+ E L P+SPY+A+KA SD+L L + +T+G++ +TRC
Sbjct: 121 G-RFLHVSTDEVYGSIDTGSWAEGHPLAPNSPYAASKAGSDLLALAYHQTHGMDVVVTRC 179
Query: 176 TNNYGPYQFPEKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRAIEAVLLKGEARE 235
+NNYGP QFPEK+IP + R GL VP+YG G+N+RDWL+V DH R + L G A E
Sbjct: 180 SNNYGPRQFPEKMIPLFVTRLLDGLDVPVYGDGRNIRDWLHVSDHCRGLALALGAGRAGE 239
Query: 236 IYNISAGEERTNLEVVRTILRIMDKDESLIEFVEDRPGHDIRYSLDSWKIIRELKWRPKY 295
+Y+I G E TNLE+ +L S I FV DR GHD RYSLD KI EL +RP+
Sbjct: 240 VYHIGGGWEATNLELTEILLEACGARRSRISFVTDRKGHDRRYSLDYSKIAGELGYRPRV 299
Query: 296 RFEEGIKKTVEWYLENEWWW 315
F +GI +TV WY N WW
Sbjct: 300 DFTDGIAETVAWYRANRSWW 319
>gb|AAF59935.1| (AF237895) dTDP-D-glucose 4,6-dehydratase [Streptomyces
antibioticus]
Length = 335
Score = 309 bits (784), Expect = 2e-83
Identities = 154/323 (47%), Positives = 210/323 (64%), Gaps = 9/323 (2%)
Query: 1 MRILVTGGMGFIGSNFIRYILEKHNDWE-----VINLDKLTYGSNPANLKDIQDDPRYTF 55
M +LVTG GFIGS ++ ++LE + LDKLTY N + DDP TF
Sbjct: 1 MNLLVTGAAGFIGSRYVHHLLEAARAGGEPAPVITVLDKLTYAGVLGN---VPDDPAVTF 57
Query: 56 VKGDVADFELVRELIKKVDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKENP 115
V+GD+AD LV L+ + D +VHFAAESHVDRSI+SP F+ +NV+GT LL+A +
Sbjct: 58 VRGDIADAPLVDSLMAEADQVVHFAAESHVDRSITSPGTFVRTNVLGTQMLLDACLRHGV 117
Query: 116 GVRLVHISTDEVYGDILKGSFTEEDRLMPSSPYSATKAASDMLVLGWARTYGLNASITRC 175
G VH+STDEVYG I GS+ E L P+SPYSA+KA+SD+L L + RT+GL+ +TRC
Sbjct: 118 GP-FVHVSTDEVYGSIEHGSWPEHQPLCPNSPYSASKASSDLLALSYHRTHGLDVRVTRC 176
Query: 176 TNNYGPYQFPEKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRAIEAVLLKGEARE 235
+NNYGP+QFPEKL+P + GL+VP+YG G NVR+WL+V+DH ++ V +G E
Sbjct: 177 SNNYGPHQFPEKLVPLFVTNLLDGLRVPLYGDGLNVREWLHVDDHCLGVDLVRTQGRPGE 236
Query: 236 IYNISAGEERTNLEVVRTILRIMDKDESLIEFVEDRPGHDIRYSLDSWKIIRELKWRPKY 295
+Y+I G E TN ++ +L +++ V DR GHD RY+LD K EL +RP+
Sbjct: 237 VYHIGGGTELTNRDLTGLLLDAFGVGWDVVDPVADRKGHDRRYALDCAKAADELGYRPRR 296
Query: 296 RFEEGIKKTVEWYLENEWWWKPL 318
F EGI +T++WY +N WW+PL
Sbjct: 297 DFAEGIARTIDWYRDNRAWWEPL 319
>pir||T51106 dTDPglucose 4,6-dehydratase (EC 4.2.1.46) [validated] -
Streptomyces antibioticus (ATCC 11891)
>gi|5902170|gb|AAD55454.1| (AF055579) dehydratase
[Streptomyces antibioticus]
Length = 335
Score = 309 bits (782), Expect = 4e-83
Identities = 152/323 (47%), Positives = 210/323 (64%), Gaps = 9/323 (2%)
Query: 1 MRILVTGGMGFIGSNFIRYILEKHNDWE-----VINLDKLTYGSNPANLKDIQDDPRYTF 55
M +LVTG GFIGS ++ ++LE + LDKLTY N + DDP TF
Sbjct: 1 MNLLVTGAAGFIGSRYVHHLLEATRRGREPAPVITVLDKLTYAGVLGN---VPDDPAVTF 57
Query: 56 VKGDVADFELVRELIKKVDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKENP 115
V+GD+AD LV L+ + D +VHFAAE+HVDRSI+SP F+ +NV+GT LL+A +
Sbjct: 58 VRGDIADAPLVDSLMAEADQVVHFAAETHVDRSITSPGTFVRTNVLGTQVLLDAALRHGV 117
Query: 116 GVRLVHISTDEVYGDILKGSFTEEDRLMPSSPYSATKAASDMLVLGWARTYGLNASITRC 175
G VH+STDEVYG I GS+ E L P+SPYSA+KA+SD+L L + RT+GL+ +TRC
Sbjct: 118 GP-FVHVSTDEVYGSIEHGSWPEHQPLCPNSPYSASKASSDLLALSYHRTHGLDVRVTRC 176
Query: 176 TNNYGPYQFPEKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRAIEAVLLKGEARE 235
+NNYGP+QFPEK++P + GL+VP+YG G NVR+WL+V+DH ++ V +G E
Sbjct: 177 SNNYGPHQFPEKIVPLFVTNLLDGLRVPLYGDGLNVREWLHVDDHCLGVDLVRTQGRPGE 236
Query: 236 IYNISAGEERTNLEVVRTILRIMDKDESLIEFVEDRPGHDIRYSLDSWKIIRELKWRPKY 295
+Y+I G E TN ++ +L +++ V DR GHD RY+LD K EL +RP+
Sbjct: 237 VYHIGGGTELTNRDLTGLLLDAFGVGWDVVDPVADRKGHDRRYALDCAKAADELGYRPRR 296
Query: 296 RFEEGIKKTVEWYLENEWWWKPL 318
F EGI +T++WY +N WW+PL
Sbjct: 297 DFAEGIARTIDWYRDNRAWWEPL 319
>sp|P39630|SPSJ_BACSU SPORE COAT POLYSACCHARIDE BIOSYNTHESIS PROTEIN SPSJ
>gi|629079|pir||S39727 dTDPglucose 4,6-dehydratase (EC
4.2.1.46) spsJ - Bacillus subtilis
>gi|413996|emb|CAA51628.1| (X73124) ipa-72d [Bacillus
subtilis] >gi|2636318|emb|CAB15809.1| (Z99123) alternate
gene name: ipa-72d [Bacillus subtilis]
Length = 315
Score = 308 bits (780), Expect = 7e-83
Identities = 156/312 (50%), Positives = 214/312 (68%), Gaps = 6/312 (1%)
Query: 4 LVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDVADF 63
L+TGG GFIG F + +L + D + LDKLTY S+P ++ ++ + R+ FVKGD++
Sbjct: 6 LITGGAGFIGLTFTKLML-RETDARITVLDKLTYASHPEEMEKLKQNSRFRFVKGDISVQ 64
Query: 64 ELV-RELIKKVDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKENPGVRLVHI 122
E + R + D ++HFAAESHVDRSIS + F+ +NV+GTY L EA+ K +L+HI
Sbjct: 65 EDIDRAFDETYDGVIHFAAESHVDRSISQAEPFITTNVMGTYRLAEAVLK-GKAKKLIHI 123
Query: 123 STDEVYGDILKG--SFTEEDRLMPSSPYSATKAASDMLVLGWARTYGLNASITRCTNNYG 180
STDEVYGD+ +FTE L P++PYSA+KA+SD+LVL + +T+ L A ITRC+NNYG
Sbjct: 124 STDEVYGDLKADDPAFTETTPLSPNNPYSASKASSDLLVLSYVKTHKLPAIITRCSNNYG 183
Query: 181 PYQFPEKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRAIEAVLLKGEAREIYNIS 240
PYQ EK+IP I AK GL VP+YG G +RDWL+ EDH RAI+ +L KG E+YNI
Sbjct: 184 PYQHSEKMIPTIIRHAKQGLPVPLYGDGLQIRDWLFAEDHCRAIKLILEKGTDGEVYNIG 243
Query: 241 AGEERTNLEVVRTILRIMDKDESLIEFVEDRPGHDIRYSLDSWKIIRELKWRPKYRFEEG 300
G ERTN E+ IL+ + +E L VEDR GHD RY++++ K+ EL WR + FEEG
Sbjct: 244 GGNERTNKELASVILKHLGCEE-LFAHVEDRKGHDRRYAINASKLKNELGWRQEVTFEEG 302
Query: 301 IKKTVEWYLENE 312
I +T++WY +N+
Sbjct: 303 IARTIQWYTDND 314
>gb|AAF01814.1|AF187532_10 (AF187532) putative dTDP-glucose-4,6-dehydratase [Streptomyces
nogalater]
Length = 350
Score = 305 bits (774), Expect = 4e-82
Identities = 157/325 (48%), Positives = 210/325 (64%), Gaps = 10/325 (3%)
Query: 1 MRILVTGGMGFIGSNFIRYILEKHNDW------EVINLDKLTYGSNPANLKDIQDDPRYT 54
+ ILVTG +GFIGS ++R +LE V LDKLTY N NL ++ D R
Sbjct: 11 VNILVTGAVGFIGSAYVRMLLENRAPGAGAPAVRVTVLDKLTYAGNLTNLDAVRGD-RLR 69
Query: 55 FVKGDVADFELVRELIKKVDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKEN 114
FV+GD+ D ELV EL+ D +VHFAAESHVDRSI + D+F+ +NV+GT LL+A +
Sbjct: 70 FVRGDILDAELVDELMAHSDQVVHFAAESHVDRSIRAADDFVLTNVVGTQRLLDAALRH- 128
Query: 115 PGVR-LVHISTDEVYGDILKGSFTEEDRLMPSSPYSATKAASDMLVLGWARTYGLNASIT 173
GV V +STDEVYG I GS+ EE L P+SPY+A+KA++D++ RT+GL+ +T
Sbjct: 129 -GVEPFVLVSTDEVYGSIASGSWPEEHPLSPNSPYAASKASADLMAFACHRTHGLDVRVT 187
Query: 174 RCTNNYGPYQFPEKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRAIEAVLLKGEA 233
RC+NNYGP Q PEKLIP+ + GL VP+YG G+NVR+WL+VEDH R ++ V G
Sbjct: 188 RCSNNYGPRQHPEKLIPRFVTNLLDGLPVPLYGDGRNVREWLHVEDHCRGVDLVRTAGRP 247
Query: 234 REIYNISAGEERTNLEVVRTILRIMDKDESLIEFVEDRPGHDIRYSLDSWKIIRELKWRP 293
+Y+I G E +N E+V +L + D S + V DR GHD+RYSLD + EL +RP
Sbjct: 248 GGVYHIGGGRELSNRELVGMLLELCGADWSSVRHVPDRKGHDLRYSLDWGRAREELGYRP 307
Query: 294 KYRFEEGIKKTVEWYLENEWWWKPL 318
F G++ TV+WY EN WW+PL
Sbjct: 308 AREFSSGLRSTVQWYRENRSWWEPL 332
>sp|P55295|RFBB_XANCA DTDP-GLUCOSE 4,6-DEHYDRATASE >gi|1073090|pir||B49906 rfbB homolog -
Xanthomonas campestris pv. campestris
>gi|398120|gb|AAA16192.1| (L23941) TDP-glucose
oxireductase [Xanthomonas campestris]
Length = 351
Score = 305 bits (773), Expect = 5e-82
Identities = 160/331 (48%), Positives = 206/331 (61%), Gaps = 22/331 (6%)
Query: 4 LVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDVADF 63
LVT G GFIG+NF+ + + V+NLD LTY N L ++ + + FVKGD+ D
Sbjct: 5 LVTRGAGFIGANFVLEAVSR--GIRVVNLDALTYAGNLNTLASLEGNADHIFVKGDIGDG 62
Query: 64 ELVRELIKK--VDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRK--------E 113
LV L+++ DA+++FAAESHVDRSI P F+ +NV+GT LLEA+R
Sbjct: 63 ALVTRLLQEHQPDAVLNFAAESHVDRSIEGPGAFIQTNVVGTLALLEAVRDYWKALPDTR 122
Query: 114 NPGVRLVHISTDEVYGDILK-GSFTEEDRLMPSSPYSATKAASDMLVLGWARTYGLNASI 172
R +H+STDEVYG + + G FTE P+SPYSA+KAASD LV + TYGL
Sbjct: 123 RDAFRFLHVSTDEVYGTLGETGKFTETTPYAPNSPYSASKAASDHLVRAFHHTYGLPVLT 182
Query: 173 TRCTNNYGPYQFPEKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRAIEAVLLKGE 232
T C+NNYGPY FPEKLIP I +A G +P+YG GK VRDWL+V DH AI VL KG
Sbjct: 183 TNCSNNYGPYHFPEKLIPLVIAKALAGEPLPVYGDGKQVRDWLFVSDHCEAIRTVLAKGR 242
Query: 233 AREIYNISAGEERTNLEVVRTILRIMDKD---------ESLIEFVEDRPGHDIRYSLDSW 283
E YN+ ER N+EVV+ I ++D+ ES I +V DRPGHD RY++D+
Sbjct: 243 VGETYNVGGNSERQNIEVVQAICALLDQHRPREDGKPRESQIAYVTDRPGHDRRYAIDAS 302
Query: 284 KIIRELKWRPKYRFEEGIKKTVEWYLENEWW 314
K+ EL W P Y FE+GI TV+WYL N+ W
Sbjct: 303 KLKDELGWEPAYTFEQGIALTVDWYLTNQTW 333
>pir||T48867 dTDPglucose 4,6-dehydratase (EC 4.2.1.46) [validated] -
Streptomyces argillaceus >gi|1814005|emb|CAA71847.1|
(Y10907) TDP-D-Glucose-4,6,-dehydratase [Streptomyces
argillaceus] >gi|3334820|emb|CAA07755.1| (AJ007932)
dTDP-glucose 4,6-dehydratase [Streptomyces argillaceus]
Length = 331
Score = 305 bits (772), Expect = 6e-82
Identities = 157/319 (49%), Positives = 208/319 (64%), Gaps = 5/319 (1%)
Query: 3 ILVTGGMGFIGSNFIRYILEKHN--DWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDV 60
ILVTGG GFIGS+++R +L D V LDKLTY NL ++ D R+ FV+GD+
Sbjct: 6 ILVTGGAGFIGSHYVRTLLGPRGVPDVTVTVLDKLTYAGTLTNLAEVSDSDRFRFVRGDI 65
Query: 61 ADFELVRELIKKVDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKENPGVR-L 119
D LV +L+ D +VHFAAESHVDRSI +F+ +NV GT TLL+A ++ G+
Sbjct: 66 CDAPLVDDLLAVHDQVVHFAAESHVDRSILGAADFVRTNVTGTQTLLDAALRQ--GIETF 123
Query: 120 VHISTDEVYGDILKGSFTEEDRLMPSSPYSATKAASDMLVLGWARTYGLNASITRCTNNY 179
VHISTDEVYG I GS+ E + P+S YSA KA+SD++ L + RT+GL+ +TRC+NNY
Sbjct: 124 VHISTDEVYGSIDAGSWPETAPVSPNSLYSAAKASSDLVALAYHRTHGLDVRVTRCSNNY 183
Query: 180 GPYQFPEKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRAIEAVLLKGEAREIYNI 239
G +QFPEK+IP + G +VP+YG G NVRDWL+V+DHVRAIE V G A E+YNI
Sbjct: 184 GSHQFPEKVIPLFVTSLLDGREVPLYGDGTNVRDWLHVDDHVRAIELVRTGGRAGEVYNI 243
Query: 240 SAGEERTNLEVVRTILRIMDKDESLIEFVEDRPGHDIRYSLDSWKIIRELKWRPKYRFEE 299
G E +N E+ + +L + +V DR GHD RYS+D KI REL +RP F +
Sbjct: 244 GGGTELSNKELTQLLLDACGAGWDRVRYVTDRKGHDRRYSVDCTKIRRELGYRPAREFGD 303
Query: 300 GIKKTVEWYLENEWWWKPL 318
+ +TV WY + WW+PL
Sbjct: 304 ALAETVAWYRHHRAWWEPL 322
>gb|AAD05454.1| (AF064070) putative dTDP-D-glucose 4,6-dehydratase [Burkholderia
pseudomallei]
Length = 353
Score = 304 bits (771), Expect = 8e-82
Identities = 160/332 (48%), Positives = 209/332 (62%), Gaps = 21/332 (6%)
Query: 3 ILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDVAD 62
ILVTGG GFIG+NF+ L + +D V+N+DKLTY N LK +Q +P++ F + D+ D
Sbjct: 2 ILVTGGAGFIGANFVLDWLAQ-SDEAVLNVDKLTYAGNLGTLKSLQGNPKHVFARVDICD 60
Query: 63 FELVRELIK--KVDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRK-------- 112
+ L+ K AIVHFAAESHVDRSI P +F+ +NV+GT+TLLEA R+
Sbjct: 61 RAAIDALLAQHKPRAIVHFAAESHVDRSIHGPADFVQTNVVGTFTLLEAARQYWSALGPD 120
Query: 113 ENPGVRLVHISTDEVYGDILKGS--FTEEDRLMPSSPYSATKAASDMLVLGWARTYGLNA 170
R +H+STDEV+G + F+E P+SPYSATKA SD LV + TYGL
Sbjct: 121 AKAAFRFLHVSTDEVFGSLSPADPQFSETTPYAPNSPYSATKAGSDHLVRAYHHTYGLPV 180
Query: 171 SITRCTNNYGPYQFPEKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRAIEAVLLK 230
T C+NNYGPYQFPEKLIP I A G +P+YG G+NVRDWLYV DH AI VL +
Sbjct: 181 LTTNCSNNYGPYQFPEKLIPLMIANALGGKPLPVYGDGQNVRDWLYVGDHCSAIREVLAR 240
Query: 231 GEAREIYNISAGEERTNLEVVRTILRIMDKD--------ESLIEFVEDRPGHDIRYSLDS 282
G E YN+ E+ NL+VV T+ ++D+ I +V DRPGHD RY++D+
Sbjct: 241 GVPGETYNVGGWNEKKNLDVVHTLCDLLDEARPKAGGSYRDQITYVTDRPGHDRRYAIDA 300
Query: 283 WKIIRELKWRPKYRFEEGIKKTVEWYLENEWW 314
K+ REL W+P FE G+ KTV WYL+++ W
Sbjct: 301 RKLERELGWKPAETFETGLAKTVRWYLDHQEW 332
>emb|CAB61555.1| (AL133171) putative dehydratase [Streptomyces coelicolor A3(2)]
Length = 324
Score = 302 bits (766), Expect = 3e-81
Identities = 156/320 (48%), Positives = 203/320 (62%), Gaps = 5/320 (1%)
Query: 1 MRILVTGGMGFIGSNFIRYILEKHNDW--EVINLDKLTYGSNPANLKDIQDDPRYTFVKG 58
M ILVTG GFIGS ++R +L V LD LTY + ANL+ PR FV G
Sbjct: 1 MNILVTGAAGFIGSRYVRGLLASDAPGAPRVTVLDALTYAGSTANLE--LGHPRLEFVHG 58
Query: 59 DVADFELVRELIKKVDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKENPGVR 118
D+ D LV L D +VHFAAESHVDRSI + +F+ +NV+GT LL+A + G
Sbjct: 59 DIRDAALVDRLTAGADQVVHFAAESHVDRSIHAASDFVLTNVVGTQNLLDAALRHGVGP- 117
Query: 119 LVHISTDEVYGDILKGSFTEEDRLMPSSPYSATKAASDMLVLGWARTYGLNASITRCTNN 178
VH+STDEVYG + GS TEE L PSSPYSA+KA+ D+L L + RT+GL+ +TRC+NN
Sbjct: 118 FVHVSTDEVYGSVDAGSATEEHPLRPSSPYSASKASGDLLALSYHRTHGLDVRVTRCSNN 177
Query: 179 YGPYQFPEKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRAIEAVLLKGEAREIYN 238
YGP+QFPEKL+P + R G +VP+YG G+NVRDWL+V+DH R ++ V +G A E+YN
Sbjct: 178 YGPHQFPEKLVPLFVTRLLDGHRVPLYGDGRNVRDWLHVDDHCRGVDLVRTRGRAGEVYN 237
Query: 239 ISAGEERTNLEVVRTILRIMDKDESLIEFVEDRPGHDIRYSLDSWKIIRELKWRPKYRFE 298
I G E +N ++ +L I VEDR GHD+RYS+D K EL +RP
Sbjct: 238 IGGGTELSNRDLTGLLLDACGAGPDRIVHVEDRKGHDLRYSVDWSKAREELGYRPHRDLA 297
Query: 299 EGIKKTVEWYLENEWWWKPL 318
G+ +TV WY +N WW+PL
Sbjct: 298 TGLAETVAWYRDNRAWWEPL 317
>pir||B82828 dTDP-glucose 4,6-dehydratase XF0255 [imported] - Xylella fastidiosa
(strain 9a5c) >gi|9105070|gb|AAF83068.1|AE003879_3
(AE003879) dTDP-glucose 4,6-dehydratase [Xylella
fastidiosa]
Length = 353
Score = 298 bits (754), Expect = 8e-80
Identities = 160/339 (47%), Positives = 212/339 (62%), Gaps = 22/339 (6%)
Query: 4 LVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDVADF 63
LVTGG GFIG NF+ + + VINLD LTY + L + + FV+GD+ D
Sbjct: 7 LVTGGAGFIGGNFVLQAISLGH--RVINLDALTYAGHLETLALLDGCAEHLFVRGDIGDR 64
Query: 64 ELVRELIK--KVDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAI--------RKE 113
LV L+ + DA+++FAAESHVDRSI +P F+ +NV+GT LLEA+
Sbjct: 65 ALVSCLLDTHRPDAVLNFAAESHVDRSIDAPAAFIQTNVVGTLLLLEAVCGYWKALPEAA 124
Query: 114 NPGVRLVHISTDEVYGDILK-GSFTEEDRLMPSSPYSATKAASDMLVLGWARTYGLNASI 172
R +H+STDEVYG + + G+FTE P+SPYSA+KAASD LV + TYGL
Sbjct: 125 RAAFRFLHVSTDEVYGSLGETGAFTERTAYAPNSPYSASKAASDHLVRAFHHTYGLPVLT 184
Query: 173 TRCTNNYGPYQFPEKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRAIEAVLLKGE 232
T C+NNYGPY FPEKLIP I +A G +P+YG G++VRDWL+V DH A+ AVL G
Sbjct: 185 THCSNNYGPYHFPEKLIPLVITKALAGEPLPVYGDGRHVRDWLFVGDHCTALCAVLAGGR 244
Query: 233 AREIYNISAGEERTNLEVVRTILRIMDKD---------ESLIEFVEDRPGHDIRYSLDSW 283
E YNI ER NLEVVR I R++D+ +S I V DRPGHD RY++D+
Sbjct: 245 VGETYNIGGQAERENLEVVRMICRLLDERRPRADGQSYQSQIVHVADRPGHDRRYAIDTS 304
Query: 284 KIIRELKWRPKYRFEEGIKKTVEWYLENEWWWKPLINER 322
K++ EL W P YRFE+G+ TV+WYL+++ W + ++ R
Sbjct: 305 KLVSELGWAPVYRFEQGLALTVDWYLQHQDWVRAVLQGR 343
>gb|AAD45555.1|U70376_20 (U70376) SpcJ [Streptomyces flavopersicus]
Length = 328
Score = 295 bits (748), Expect = 4e-79
Identities = 151/323 (46%), Positives = 204/323 (62%), Gaps = 7/323 (2%)
Query: 1 MRILVTGGMGFIGSNFIRYIL-----EKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTF 55
MRILVTGG GFIGS F+R +L E++ W + LDKLTY ANL + PRY F
Sbjct: 1 MRILVTGGAGFIGSEFVRSLLLTAEPERNTPWVTV-LDKLTYAGVAANLDPVAGHPRYRF 59
Query: 56 VKGDVADFELVRELIKKVDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKENP 115
V+GD+ D L +++ DA+VHFAAESHVDRSIS F+ +NV+GT +L+A +
Sbjct: 60 VRGDICDAHLADHVMRGHDAVVHFAAESHVDRSISGAGPFVTTNVVGTQVMLDAAYRHGV 119
Query: 116 GVRLVHISTDEVYGDILKGSFTEEDRLMPSSPYSATKAASDMLVLGWARTYGLNASITRC 175
G R V +STDEVYG I +GS++E L P+SPY+A+KA +D+L + RT+G++ +TRC
Sbjct: 120 G-RFVQVSTDEVYGSISEGSWSEGAPLDPNSPYAASKAGADLLAHSYHRTHGMDVVVTRC 178
Query: 176 TNNYGPYQFPEKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRAIEAVLLKGEARE 235
+NNYGP QFPEK+IP I G +VP+YG G+++RDWL+V DH R I L G+A E
Sbjct: 179 SNNYGPRQFPEKVIPLFITNLLDGREVPLYGDGQHMRDWLHVSDHCRGIRLALRHGKAGE 238
Query: 236 IYNISAGEERTNLEVVRTILRIMDKDESLIEFVEDRPGHDIRYSLDSWKIIRELKWRPKY 295
Y+I G E TN + +L + + V DR GHD+RYSL + L + +
Sbjct: 239 TYHIGGGTELTNEALTGLLLEATGRGWDSVRRVPDRKGHDLRYSLRCDNARQHLGYEAEV 298
Query: 296 RFEEGIKKTVEWYLENEWWWKPL 318
FE+G+ TV WY N WW+PL
Sbjct: 299 GFEKGLADTVAWYRNNRSWWEPL 321
>sp|P29782|STRE_STRGR DTDP-GLUCOSE 4,6-DEHYDRATASE >gi|68393|pir||DWSMGG dTDPglucose
4,6-dehydratase (EC 4.2.1.46) [validated] - Streptomyces
griseus >gi|581677|emb|CAA44444.1| (X62567) dTDP-glucose
dehydratase [Streptomyces griseus]
Length = 328
Score = 294 bits (746), Expect = 7e-79
Identities = 150/319 (47%), Positives = 205/319 (64%), Gaps = 4/319 (1%)
Query: 3 ILVTGGMGFIGSNFIRYILEKHNDWEVI--NLDKLTYGSNPANLKDIQDDPRYTFVKGDV 60
+LVTG GFIGS ++R +L +V+ LD LTY NP NL ++ PRY F +GD+
Sbjct: 5 LLVTGAAGFIGSQYVRTLLGPGGPPDVVVTALDALTYAGNPDNLAAVRGHPRYRFERGDI 64
Query: 61 ADFELVRELIKKVDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKENPGVRLV 120
D R ++ D +VH AAESHVDRS+ F+ +NV GT TLL+A + V
Sbjct: 65 CDAP-GRRVMAGQDQVVHLAAESHVDRSLLDASVFVRTNVHGTQTLLDAATRHGVA-SFV 122
Query: 121 HISTDEVYGDILKGSFTEEDRLMPSSPYSATKAASDMLVLGWARTYGLNASITRCTNNYG 180
+STDEVYG + GS+TE++ L P+SPYSA+KA+ D+L L ++GL+ +TRC+NNYG
Sbjct: 123 QVSTDEVYGSLEHGSWTEDEPLRPNSPYSASKASGDLLALAHHVSHGLDVRVTRCSNNYG 182
Query: 181 PYQFPEKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRAIEAVLLKGEAREIYNIS 240
P QFPEKLIP+ I G +VP+YG G NVR+WL+V+DHVR IEAV +G A +YNI
Sbjct: 183 PRQFPEKLIPRFITLLMDGHRVPLYGDGLNVREWLHVDDHVRGIEAVRTRGRAGRVYNIG 242
Query: 241 AGEERTNLEVVRTILRIMDKDESLIEFVEDRPGHDIRYSLDSWKIIRELKWRPKYRFEEG 300
G +N E+V +L D +E+VEDR GHD RY++DS +I REL + P +G
Sbjct: 243 GGATLSNKELVGLLLEAAGADWGSVEYVEDRKGHDRRYAVDSTRIQRELGFAPAVDLADG 302
Query: 301 IKKTVEWYLENEWWWKPLI 319
+ TV WY ++ WW+PL+
Sbjct: 303 LAATVAWYHKHRSWWEPLV 321
>dbj|BAB07083.1| (AP001518) spore coat polysaccharide synthesis (dTDP glucose 4,
6-dehydratase) [Bacillus halodurans]
Length = 321
Score = 294 bits (744), Expect = 1e-78
Identities = 149/310 (48%), Positives = 201/310 (64%), Gaps = 4/310 (1%)
Query: 2 RILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDVA 61
+ILVTGG GFIGS+FI +L+ + + N+D LTY N+ P Y F+ D+
Sbjct: 4 QILVTGGAGFIGSHFIEALLQHKPTYHITNVDVLTYAGKIENMSGFTKHPNYRFISADIG 63
Query: 62 DFE-LVRELIKKVDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKENPGVRLV 120
D + L+ + D IVHFAAE+HVDRSI +P FL +N++GT+ LL A+ K +++
Sbjct: 64 DADQLLGAFDRTYDVIVHFAAETHVDRSIHNPMVFLETNILGTHNLLLAVLK-GYAKKIL 122
Query: 121 HISTDEVYGDI-LKG-SFTEEDRLMPSSPYSATKAASDMLVLGWARTYGLNASITRCTNN 178
+ISTDEVYG + +K FTE+ L ++PYSA+KA D+L + +TY ITRC+NN
Sbjct: 123 YISTDEVYGSLGMKDVPFTEQSPLAANNPYSASKAGGDLLARSFYKTYQAPVIITRCSNN 182
Query: 179 YGPYQFPEKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRAIEAVLLKGEAREIYN 238
YGP Q EKLIPK I A K+P+YG G +RDWLYV DH RA+ ++ GE EIYN
Sbjct: 183 YGPRQDKEKLIPKIIANALTNKKIPLYGDGLQIRDWLYVTDHCRALTTIMEHGEIGEIYN 242
Query: 239 ISAGEERTNLEVVRTILRIMDKDESLIEFVEDRPGHDIRYSLDSWKIIRELKWRPKYRFE 298
I G ERTNLE+ + IL I+ KD LI VEDR GHD RY+++ KI ++L WRP FE
Sbjct: 243 IGGGNERTNLEITKQILNILGKDHDLINHVEDRKGHDRRYAINWGKIHKQLGWRPMVAFE 302
Query: 299 EGIKKTVEWY 308
+G+ +TV+WY
Sbjct: 303 DGLAETVQWY 312
>pir||T30873 dNDP-glucose dehydratase - Streptomyces viridochromogenes
>gi|1911170|emb|CAA72715.1| (Y11985) dNDP-glucose
dehydratase [Streptomyces viridochromogenes]
Length = 355
Score = 292 bits (739), Expect = 5e-78
Identities = 151/322 (46%), Positives = 206/322 (63%), Gaps = 5/322 (1%)
Query: 3 ILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDVAD 62
+LV GG GFIGS ++R ++ + V LDKLTY N ANL+ + RYTFV GD+ D
Sbjct: 14 VLVIGGAGFIGSQYVRELVRDGDPARVTVLDKLTYAGNLANLEPVAG--RYTFVHGDICD 71
Query: 63 FELVRELIKKVDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKENPGVRLVHI 122
L+ E++ D +V+FAAESHVDRSI+ F+ +NV G L++ + E R+V +
Sbjct: 72 ARLLAEVVPGHDLVVNFAAESHVDRSIADAAPFIRTNVQGVQALMQ-VCLEAGTARIVQV 130
Query: 123 STDEVYGDILKGSFTEEDRLMPSSPYSATKAASDMLVLGWARTYGLNASITRCTNNYGPY 182
STDEVYG I GS+ E+ + P+SPY+A+KA DM+ L +ART+GL S+TRC NNYGPY
Sbjct: 131 STDEVYGSIETGSWDEDAPIAPNSPYAASKAGGDMVALAYARTHGLPVSVTRCGNNYGPY 190
Query: 183 QFPEKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRAIEAVLLKGEAREIYNISAG 242
QFPEK++P R G +P+YG G NVRDW++V DHVR I V +G ++Y+I+
Sbjct: 191 QFPEKVVPLFTTRLLDGHSIPLYGDGGNVRDWVHVSDHVRGIRLVAERGLPGQVYHIAGS 250
Query: 243 EERTNLEVVRTILRIMDKDESLIEFVEDRPGHDIRYSLDSWKIIRELKWRPKYRFEEGIK 302
E TNLE+ + +L + +E V DR GHD RYSL + + L + P+ FE+G+
Sbjct: 251 AELTNLELTQQLLDALGAGWDRVERVPDRKGHDRRYSLCDAR-LGALGYAPRVSFEQGLA 309
Query: 303 KTVEWYLENEWWWKPLINERVL 324
TV WY EN WW+PL NER L
Sbjct: 310 DTVRWYAENRDWWEPL-NERAL 330
>emb|CAA07387.1| (AJ006985) StrE [Streptomyces glaucescens]
Length = 329
Score = 291 bits (737), Expect = 8e-78
Identities = 150/319 (47%), Positives = 203/319 (63%), Gaps = 4/319 (1%)
Query: 2 RILVTGGMGFIGSNFIRYILEKHN--DWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGD 59
R+LVTGG GFIGS+++R +L D V LD L+Y N ANL ++D P FV GD
Sbjct: 4 RLLVTGGAGFIGSHYVRTLLGPDGPPDAVVTVLDALSYAGNLANLDPVRDHPPVRFVHGD 63
Query: 60 VADFELVRELIKKVDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKENPGVRL 119
+ D +LVR + + D +VH AAESHVDRS+ F+ +N GT TLL+A +
Sbjct: 64 ICDADLVRVMAGQ-DQVVHLAAESHVDRSLLDAAAFVRTNAGGTQTLLDAALRHGVAP-F 121
Query: 120 VHISTDEVYGDILKGSFTEEDRLMPSSPYSATKAASDMLVLGWARTYGLNASITRCTNNY 179
V +STDEVYG + GS+TE++ + P+SPY+A+KA+ D+L L ++GL+ ITRC+NNY
Sbjct: 122 VQVSTDEVYGSLETGSWTEDEAVRPNSPYAASKASGDLLALAMHVSHGLDVRITRCSNNY 181
Query: 180 GPYQFPEKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRAIEAVLLKGEAREIYNI 239
GPYQFPEKL+P+ + G KVP+YG G +VRDWL+V+DHVR IEAV +G A +YNI
Sbjct: 182 GPYQFPEKLVPRFVTLLLEGRKVPLYGDGLHVRDWLHVDDHVRGIEAVRARGRAGRVYNI 241
Query: 240 SAGEERTNLEVVRTILRIMDKDESLIEFVEDRPGHDIRYSLDSWKIIRELKWRPKYRFEE 299
G N ++V +L+ +E V DR GHD RYS+D+ +I REL P
Sbjct: 242 GGGTSLANRDLVDLLLKACGAGWDRVEHVPDRKGHDRRYSVDASRIRRELGHVPATDLST 301
Query: 300 GIKKTVEWYLENEWWWKPL 318
G+ TV WY +N WW+PL
Sbjct: 302 GLAATVAWYRDNRAWWEPL 320
>emb|CAB65206.1| (AJ007311) RmlB protein [Legionella pneumophila]
Length = 351
Score = 291 bits (736), Expect = 1e-77
Identities = 148/319 (46%), Positives = 208/319 (64%), Gaps = 13/319 (4%)
Query: 3 ILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDVAD 62
+LVTG GFIGSNF++++ +K+ + ++I+LDKLTY N ANL ++ + + FV+GD+ D
Sbjct: 25 LLVTGAAGFIGSNFVKFMNDKYPEIKIISLDKLTYAGNKANLSEMAECKNHLFVQGDILD 84
Query: 63 FELVRELIKK--VDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRK-------- 112
LV L+++ +D +VHFAAESHVD SI +P FL +NVIGT+TLLEA R
Sbjct: 85 KSLVLSLLREYEIDTLVHFAAESHVDNSIDNPQIFLETNVIGTFTLLEAARIYWLNERQW 144
Query: 113 ENPGVRLVHISTDEVYGDILKG--SFTEEDRLMPSSPYSATKAASDMLVLGWARTYGLNA 170
+ R H+STDEVYG + + +FTE++ P+SPYSA+KA+SD +V + TYGL
Sbjct: 145 DKSKCRFHHVSTDEVYGSLEREEPAFTEKNSYQPNSPYSASKASSDHIVRAYYHTYGLPV 204
Query: 171 SITRCTNNYGPYQFPEKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRAIEAVLLK 230
+ + C+NNYGP Q EKLIPK + L + +YG G N+RDWLYV DH AI+ ++ K
Sbjct: 205 TTSNCSNNYGPNQHKEKLIPKVVYACVNQLPITVYGNGSNIRDWLYVMDHCEAIDTIIQK 264
Query: 231 GEAREIYNISAGEERTNLEVVRTILRIMDKDESLIEFVEDRPGHDIRYSLDSWKIIRELK 290
G E+YNI E NL +++ I ++MD D +E VEDR GHD RY++D+ KI +EL
Sbjct: 265 GALGEVYNIGGNNELDNLSLIKMICQMMD-DLKPMEIVEDRKGHDKRYAIDNSKIQKELG 323
Query: 291 WRPKYRFEEGIKKTVEWYL 309
W P+ F + TV YL
Sbjct: 324 WVPQGDFVHKLSNTVHHYL 342
>pir||S58686 dTDPglucose 4,6-dehydratase (EC 4.2.1.46) graE - Streptomyces
violaceoruber >gi|763511|gb|AAA99939.1| (L37334)
dTDP-glucose dehydratase [Streptomyces violaceoruber]
>gi|4218549|emb|CAA09638.1| (AJ011500) putative
dTDP-glucose-4,6-dehydratase [Streptomyces
violaceoruber]
Length = 321
Score = 287 bits (727), Expect = 1e-76
Identities = 145/321 (45%), Positives = 211/321 (65%), Gaps = 9/321 (2%)
Query: 1 MRILVTGGMGFIGSNFIRYILE----KHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFV 56
MR+LVTG GFIGS+++R IL + +D V +D+LTY NL + + R FV
Sbjct: 1 MRLLVTGAAGFIGSHYVREILAGSYPESDDVHVTVVDRLTYAGRRDNLPEHHE--RLDFV 58
Query: 57 KGDVADFELVRELIKKVDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKENPG 116
GD+ D +L+ ++ DA+VHFAAESHVDRS++ P F+ +NV+GT LL+A + G
Sbjct: 59 HGDICDRDLLDRVLPGHDAVVHFAAESHVDRSLTGPGEFVRTNVMGTQQLLDAAL--HAG 116
Query: 117 V-RLVHISTDEVYGDILKGSFTEEDRLMPSSPYSATKAASDMLVLGWARTYGLNASITRC 175
V R++H+STDEVYG + G++TE+ L+P+SPY+A+KA++ +GL+ ITRC
Sbjct: 117 VDRVLHVSTDEVYGSLDSGTWTEDSPLLPNSPYAASKASTTWSAAPTTVRHGLDVRITRC 176
Query: 176 TNNYGPYQFPEKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRAIEAVLLKGEARE 235
+NNYGP Q PEKLIP + R G +VP+YG G+NVR+WL+V+DH RA++ VL KG A E
Sbjct: 177 SNNYGPRQHPEKLIPNFVTRLLTGRQVPLYGDGRNVREWLHVDDHCRALQLVLTKGRAGE 236
Query: 236 IYNISAGEERTNLEVVRTILRIMDKDESLIEFVEDRPGHDIRYSLDSWKIIRELKWRPKY 295
IYNI G +N E+ +L ++ D ++ VEDR GHD RY++D KI EL + P++
Sbjct: 237 IYNIGGGSGMSNREMTARLLDLLGADWDMVRHVEDRLGHDFRYAIDDSKIREELGYAPRW 296
Query: 296 RFEEGIKKTVEWYLENEWWWK 316
E G+ V+WY ++ +W+
Sbjct: 297 SIESGLGAVVDWYRDHPDFWR 317
>gb|AAF73454.1|AF264025_5 (AF264025) putative dTDP-glucose 4, 6-dehydratase; AknR
[Streptomyces galilaeus]
Length = 323
Score = 285 bits (722), Expect = 5e-76
Identities = 145/316 (45%), Positives = 202/316 (63%), Gaps = 7/316 (2%)
Query: 1 MRILVTGGMGFIGSNFIRYILEKH----NDWEVINLDKLTYGSNPANLKDIQDDPRYTFV 56
MR+L+TGG GFIGS+++R +L V +D LTY + NL DPR F
Sbjct: 1 MRVLITGGAGFIGSHYVRSLLAGTLPGPRPSRVTVVDLLTYAGDTGNLP--LADPRLDFR 58
Query: 57 KGDVADFELVRELIKKVDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKENPG 116
+ D+ D + + ++ DA+VHFAAE+HVDRS+S P F+ +NV+GT +LLEA + G
Sbjct: 59 RLDIRDLDALLTVVPGHDAVVHFAAETHVDRSLSEPAEFVRTNVLGTQSLLEASLRGGVG 118
Query: 117 VRLVHISTDEVYGDILKGSFTEEDRLMPSSPYSATKAASDMLVLGWARTYGLNASITRCT 176
VH+STDEVYG I +G++TEE L+P+SPY+A+KA SD++ + RT+GL+ TRC
Sbjct: 119 T-FVHVSTDEVYGSIAQGTWTEEAPLLPNSPYAASKAGSDLVARSYWRTHGLDVRTTRCA 177
Query: 177 NNYGPYQFPEKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRAIEAVLLKGEAREI 236
NNYGP Q PEKLIP + G VP+YG G NVR+WL+V+DH RA+ AVL G EI
Sbjct: 178 NNYGPRQHPEKLIPLFVTELLAGRPVPLYGDGGNVREWLHVDDHCRAVHAVLTGGRPGEI 237
Query: 237 YNISAGEERTNLEVVRTILRIMDKDESLIEFVEDRPGHDIRYSLDSWKIIRELKWRPKYR 296
YNI G TN E+ +L + D S + V DR GHD+RY++D KI EL +RP
Sbjct: 238 YNIGGGTHLTNREMTAKLLALCGTDWSRVRQVPDRKGHDLRYAVDDTKIREELGYRPLRS 297
Query: 297 FEEGIKKTVEWYLENE 312
++G+++ V+WY + +
Sbjct: 298 LDDGLREVVDWYRDRQ 313
>prf||2208414C glucose phosphate thymidylate transferase [Streptomyces peucetius]
Length = 291
Score = 280 bits (708), Expect = 2e-74
Identities = 142/288 (49%), Positives = 186/288 (64%), Gaps = 2/288 (0%)
Query: 32 LDKLTYGSNPANLKDIQDDPRYTFVKGDVADFELVRELIKKVDAIVHFAAESHVDRSI-S 90
LD LTY NPANL ++ D R+ FV GD+ D LV L+ + D IVHFAAESHVDRS+ S
Sbjct: 2 LDSLTYAGNPANLDPVRGDERFAFVHGDICDAPLVDRLVAEHDQIVHFAAESHVDRSVRS 61
Query: 91 SPDNFLHSNVIGTYTLLEAIRKENPGVRLVHISTDEVYGDILKGSFTEEDRLMPSSPYSA 150
P + NV+GT TLL+A + P + VHISTDEVYG + G+ TE D L PSS Y+
Sbjct: 62 GPRSSCAPNVMGTQTLLDAALRHAPRI-FVHISTDEVYGSVDVGASTETDPLHPSSAYAG 120
Query: 151 TKAASDMLVLGWARTYGLNASITRCTNNYGPYQFPEKLIPKTIIRAKMGLKVPIYGTGKN 210
TKA+SD+L L + RT+GL+ ITRC+NNYG +Q PEK+IP+ + G +VP+YG G N
Sbjct: 121 TKASSDLLALSYHRTHGLDVRITRCSNNYGTHQHPEKVIPRFVTTLLSGGRVPLYGDGGN 180
Query: 211 VRDWLYVEDHVRAIEAVLLKGEAREIYNISAGEERTNLEVVRTILRIMDKDESLIEFVED 270
+R+WL+VEDHV A+E V G EIYNI G E +N E+ +L + +E V D
Sbjct: 181 LRNWLHVEDHVDAVELVREGGSPGEIYNIGGGTELSNKELTALLLDAVGAGWDSVELVAD 240
Query: 271 RPGHDIRYSLDSWKIIRELKWRPKYRFEEGIKKTVEWYLENEWWWKPL 318
R GHD RY++D KI L +RP+ F + + +TV WY + WW PL
Sbjct: 241 RKGHDRRYAVDHGKITALLGYRPRRDFRDSLAETVAWYRDRRSWWAPL 288
>gb|AAF78439.1|AC018748_18 (AC018748) Contains similarity to dTPD-D-glucose-4,6-dehydratase
from Sphingomonas sp.S88 gb|U51197 and contains a NAD
dependent epimerase/dehydratase PF|01370 domain.
[Arabidopsis thaliana]
>gi|10645356|gb|AAG21476.1|AC024260_19 (AC024260)
dTDP-D-glucose 4,6-dehydratase, putative; 102946-105028
[Arabidopsis thaliana]
Length = 667
Score = 279 bits (707), Expect = 3e-74
Identities = 143/330 (43%), Positives = 208/330 (62%), Gaps = 7/330 (2%)
Query: 3 ILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDVAD 62
IL+TG GFI S+ ++ + D++++ LDKL Y S+ NL P + FVKGD+A
Sbjct: 11 ILITGAAGFIASHVANRLIRNYPDYKIVVLDKLDYCSDLKNLDPSFSSPNFKFVKGDIAS 70
Query: 63 FELVRELI--KKVDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKENPGVRLV 120
+LV L+ + +D I+HFAA++HVD S + F +N+ GT+ LLEA + R +
Sbjct: 71 DDLVNYLLITENIDTIMHFAAQTHVDNSFGNSFEFTKNNIYGTHVLLEACKVTGQIRRFI 130
Query: 121 HISTDEVYGDILKGSFT---EEDRLMPSSPYSATKAASDMLVLGWARTYGLNASITRCTN 177
H+STDEVYG+ + + E +L+P++PYSATKA ++MLV+ + R+YGL TR N
Sbjct: 131 HVSTDEVYGETDEDAAVGNHEASQLLPTNPYSATKAGAEMLVMAYGRSYGLPVITTRGNN 190
Query: 178 NYGPYQFPEKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRAIEAVLLKGEAREIY 237
YGP QFPEK+IPK I+ A G +PI+G G NVR +LY ED A E VL KGE +Y
Sbjct: 191 VYGPNQFPEKMIPKFILLAMSGKPLPIHGDGSNVRSYLYCEDVAEAFEVVLHKGEIGHVY 250
Query: 238 NISAGEERTNLEVVRTILRIMDKD-ESLIEFVEDRPGHDIRYSLDSWKIIRELKWRPKYR 296
N+ ER ++V R I ++ KD ES I+FVE+RP +D RY LD K +++L W+ +
Sbjct: 251 NVGTKRERRVIDVARDICKLFGKDPESSIQFVENRPFNDQRYFLDDQK-LKKLGWQERTN 309
Query: 297 FEEGIKKTVEWYLENEWWWKPLINERVLHP 326
+E+G+KKT++WY +N WW + + HP
Sbjct: 310 WEDGLKKTMDWYTQNPEWWGDVSGALLPHP 339
>gb|AAD30579.1|AC007260_10 (AC007260) Similar to dTDP-D-glucose 4,6-dehydratase [Arabidopsis
thaliana]
Length = 669
Score = 279 bits (705), Expect = 4e-74
Identities = 146/331 (44%), Positives = 209/331 (63%), Gaps = 9/331 (2%)
Query: 3 ILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDVAD 62
IL+TG GFI S+ ++ + D++++ LDKL Y SN NL + P + FVKGD+A
Sbjct: 9 ILITGAAGFIASHVANRLIRSYPDYKIVVLDKLDYCSNLKNLNPSKHSPNFKFVKGDIAS 68
Query: 63 FELVRELI--KKVDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKENPGVRLV 120
+LV L+ + +D I+HFAA++HVD S + F +N+ GT+ LLEA + R +
Sbjct: 69 ADLVNHLLITEGIDTIMHFAAQTHVDNSFGNSFEFTKNNIYGTHVLLEACKVTGQIRRFI 128
Query: 121 HISTDEVYG----DILKGSFTEEDRLMPSSPYSATKAASDMLVLGWARTYGLNASITRCT 176
H+STDEVYG D L G+ E +L+P++PYSATKA ++MLV+ + R+YGL TR
Sbjct: 129 HVSTDEVYGETDEDALVGNH-EASQLLPTNPYSATKAGAEMLVMAYGRSYGLPVITTRGN 187
Query: 177 NNYGPYQFPEKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRAIEAVLLKGEAREI 236
N YGP QFPEKLIPK I+ A G +PI+G G NVR +LY ED A E VL KGE +
Sbjct: 188 NVYGPNQFPEKLIPKFILLAMRGQVLPIHGDGSNVRSYLYCEDVAEAFEVVLHKGEVGHV 247
Query: 237 YNISAGEERTNLEVVRTILRIMDKD-ESLIEFVEDRPGHDIRYSLDSWKIIRELKWRPKY 295
YNI +ER +V + I ++ + D E+ I+FV++RP +D RY LD K +++L W +
Sbjct: 248 YNIGTKKERRVNDVAKDICKLFNMDPEANIKFVDNRPFNDQRYFLDDQK-LKKLGWSERT 306
Query: 296 RFEEGIKKTVEWYLENEWWWKPLINERVLHP 326
+EEG+KKT++WY +N WW + + HP
Sbjct: 307 TWEEGLKKTMDWYTQNPEWWGDVSGALLPHP 337
>emb|CAC12984.1| (AJ250327) dTDP-glucose 4,6-dehydratase [Acetobacter xylinus]
Length = 349
Score = 277 bits (700), Expect = 2e-73
Identities = 150/331 (45%), Positives = 196/331 (58%), Gaps = 21/331 (6%)
Query: 1 MRILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDV 60
MRILVTGG GFIGS +R ++++ EV+N+D LTY ++ + RY ++
Sbjct: 1 MRILVTGGCGFIGSAVVRRLIDQTTH-EVLNVDALTYAASIKATEAAAQSGRYRLEVANI 59
Query: 61 ADFELVRELIKKV--DAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRK------ 112
D + + + DA++H AAESHVDRSI P F+ +N++GTYTLLEA RK
Sbjct: 60 IDAASMERIFAEFSPDAVMHLAAESHVDRSIDGPGTFVSTNIVGTYTLLEAARKWWARQD 119
Query: 113 --ENPGVRLVHISTDEVYGDILKGS--FTEEDRLMPSSPYSATKAASDMLVLGWARTYGL 168
R HISTDEV+G + G FTE P SPYSA+KA+SD LV W TYGL
Sbjct: 120 AERRKAFRFHHISTDEVFGALQPGDPPFTERTPYDPRSPYSASKASSDHLVRAWYHTYGL 179
Query: 169 NASITRCTNNYGPYQFPEKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRAIEAVL 228
TNNYGP+ FPEKLIP I A G ++P+YGTG+NVRDWL+VEDH A+ +
Sbjct: 180 PTDDRNTTNNYGPWHFPEKLIPLVTINAIEGRELPVYGTGQNVRDWLFVEDHAEALVRAV 239
Query: 229 LKGEAREIYNISAGEERTNLEVVRTILRIMDK--------DESLIEFVEDRPGHDIRYSL 280
G+ E Y I A + RTN++VV TI I+D+ LI V DRPGHD RY +
Sbjct: 240 ECGQPGETYAIGARQPRTNMQVVETICTILDELHPDLAGPHARLIRHVTDRPGHDFRYEI 299
Query: 281 DSWKIIRELKWRPKYRFEEGIKKTVEWYLEN 311
D + L W + FE GI++TV+WYL+N
Sbjct: 300 DPTHAEQALGWHARLDFEHGIRRTVQWYLDN 330
>gb|AAK41125.1| dTDP-Glucose 4,6-dehydratase (rfbB-1) [Sulfolobus solfataricus]
Length = 317
Score = 274 bits (693), Expect = 1e-72
Identities = 155/333 (46%), Positives = 215/333 (64%), Gaps = 23/333 (6%)
Query: 1 MRILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDV 60
M+I+V GG GFIGS F+R + ++ + I +D LTY NL I D Y FV+ DV
Sbjct: 1 MKIIVVGGAGFIGSAFVRELNKR--GIKPIVVDLLTYAGRKENL--IGTD--YDFVQADV 54
Query: 61 ADFELVRELIKKV--DAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKENPGVR 118
E + ++IK+ D +++FAAE+HVDRSI P +F+ +NV+GT LLEA RK N +
Sbjct: 55 RS-EKMHDIIKEYSPDIVINFAAETHVDRSIYKPQDFVTTNVLGTVNLLEASRKFN--FK 111
Query: 119 LVHISTDEVYGDILKGSFTEEDRLMPSSPYSATKAASDMLVLGWARTYGLNASITRCTNN 178
VHISTDEVYG+ E L PSSPYSA+KA++D+ V + RTYG++A I R +NN
Sbjct: 112 YVHISTDEVYGEECGD---ENSPLKPSSPYSASKASADLFVKAYVRTYGISAVIVRPSNN 168
Query: 179 YGPYQFPEKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRAIEAVLLKGEAR-EIY 237
YGP QFPEKLIPK IIR +G+ +P+YG GK RDW++VED R I V+ + E + E+Y
Sbjct: 169 YGPRQFPEKLIPKAIIRTLLGIHIPVYGDGKAERDWIFVEDTARIIFDVVSRAEWKGEVY 228
Query: 238 NISAGEERTNLEVVRTILRIMDKDESLIEFVEDRPGHDIRYSLDSWKIIRELKWRPKYRF 297
NI G+ LE+++ + + K E I+FV DRPGHD RY + + +K+ F
Sbjct: 229 NIPGGQRYNVLEILKMLEEVSGK-EVKIKFVSDRPGHDRRYCMTT-----SMKYEVT-PF 281
Query: 298 EEGIKKTVEWYLENEWWWKPLINER-VLHPTPW 329
+EG+++T EWYL N WWW+PLIN++ + PW
Sbjct: 282 KEGLRRTYEWYLNNRWWWEPLINDKFFVEDEPW 314
>emb|CAB57474.1| (Y18930) dTDP-glucose 4,6-dehydratase (rfbB) [Sulfolobus
solfataricus]
Length = 317
Score = 274 bits (693), Expect = 1e-72
Identities = 155/333 (46%), Positives = 215/333 (64%), Gaps = 23/333 (6%)
Query: 1 MRILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDV 60
M+I+V GG GFIGS F+R + ++ + I +D LTY NL I D Y FV+ DV
Sbjct: 1 MKIIVVGGAGFIGSAFVRELNKR--GIKPIVVDLLTYAGRKENL--IGTD--YDFVQADV 54
Query: 61 ADFELVRELIKKV--DAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKENPGVR 118
E + ++IK+ D +++FAAE+HVDRSI P +F+ +NV+GT LLEA RK N +
Sbjct: 55 RS-EKMHDIIKEYSPDIVINFAAETHVDRSIYKPQDFVTTNVLGTVNLLEASRKFN--FK 111
Query: 119 LVHISTDEVYGDILKGSFTEEDRLMPSSPYSATKAASDMLVLGWARTYGLNASITRCTNN 178
VHISTDEVYG+ E L PSSPYSA+KA++D+ V + RTYG++A I R +NN
Sbjct: 112 YVHISTDEVYGEECGD---ENSPLKPSSPYSASKASADLFVKAYVRTYGISAVIVRPSNN 168
Query: 179 YGPYQFPEKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRAIEAVLLKGEAR-EIY 237
YGP QFPEKLIPK IIR +G+ +P+YG GK RDW++VED R I V+ + E + E+Y
Sbjct: 169 YGPRQFPEKLIPKAIIRTLLGIHIPVYGDGKAERDWIFVEDTARIIFDVVSRAEWKGEVY 228
Query: 238 NISAGEERTNLEVVRTILRIMDKDESLIEFVEDRPGHDIRYSLDSWKIIRELKWRPKYRF 297
NI G+ LE+++ + + K E I+FV DRPGHD RY + + +K+ F
Sbjct: 229 NIPGGQRYNVLEILKMLEEVSGK-EVKIKFVSDRPGHDRRYCMTT-----SMKYEVT-PF 281
Query: 298 EEGIKKTVEWYLENEWWWKPLINER-VLHPTPW 329
+EG+++T EWYL N WWW+PLIN++ + PW
Sbjct: 282 KEGLRRTYEWYLNNRWWWEPLINDKFFVEDEPW 314
>gb|AAK41973.1| dTDP-Glucose 4,6-dehydratase (rfbB-3) [Sulfolobus solfataricus]
Length = 312
Score = 273 bits (692), Expect = 1e-72
Identities = 151/330 (45%), Positives = 212/330 (63%), Gaps = 21/330 (6%)
Query: 3 ILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDVAD 62
+++ GG GFIGS F+R + ++ + I +D LTY NL + + F++ DV
Sbjct: 1 MIIIGGAGFIGSAFVREVNKR--GIKPIVVDLLTYAGRKENLIGTEHE----FIRADVRS 54
Query: 63 FELVRELIKKVDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKENPGVRLVHI 122
E + +++K D +V+FAAE+HVDRSI P +F+ +NV+G LLEA RK + + VHI
Sbjct: 55 EE-IHDIVKNSDIVVNFAAETHVDRSIYRPQDFVTTNVLGVVNLLEAARKYD--FKYVHI 111
Query: 123 STDEVYGDILKGSFTEEDRLMPSSPYSATKAASDMLVLGWARTYGLNASITRCTNNYGPY 182
STDEVYG+ E+ L PSSPYSA+KA++D+ V + RTYG+ A I R +NNYGP
Sbjct: 112 STDEVYGEECAD---EDSPLQPSSPYSASKASADLFVKAYVRTYGIKAIIVRPSNNYGPR 168
Query: 183 QFPEKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRAIEAVLLKGEAR-EIYNISA 241
QFPEKLIPK IIR + + VPIYG G+ RDW+YVED VR I ++ + E R E+YNI
Sbjct: 169 QFPEKLIPKVIIRTFLNMHVPIYGDGRAERDWIYVEDTVRIIYDIMERSEWRGEVYNIPG 228
Query: 242 GEERTNLEVVRTILRIMDKDESLIEFVEDRPGHDIRYSLDSWKIIRELKWRPKYRFEEGI 301
G+ + L+V++ I IM K E ++FV+DRPGHD RY + + +LK+ +EG+
Sbjct: 229 GQRYSVLDVIKIIGEIMGK-EVKVKFVDDRPGHDKRYCMTT-----KLKYEVT-PLKEGL 281
Query: 302 KKTVEWYLENEWWWKPLINERVL-HPTPWK 330
+KTVEWYL N WWW+ LI ++ PWK
Sbjct: 282 RKTVEWYLNNRWWWEDLIKDKFFTEDEPWK 311
>gb|AAG09488.1|AF279639_1 (AF279639) dTDP-D-glucose-4,6-dehydratase [Salmonella enterica]
Length = 301
Score = 272 bits (688), Expect = 4e-72
Identities = 145/302 (48%), Positives = 188/302 (62%), Gaps = 28/302 (9%)
Query: 6 TGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDVADFEL 65
TGG GFIGS +R+I++ D V+N+DKLTY N +L DI + RY F D+ D
Sbjct: 1 TGGSGFIGSAVVRHIIKNTQD-TVVNIDKLTYAGNLESLSDISESNRYNFEHADICDSAE 59
Query: 66 VRELIKKV--DAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRK--------ENP 115
+ + ++ DA++H AAESHVDRSI+ P F+ +N++GTY LLEA RK +
Sbjct: 60 ITRIFEQYQPDAVMHLAAESHVDRSITGPAAFIETNIVGTYVLLEAARKYWSALGEDKKN 119
Query: 116 GVRLVHISTDEVYGDI-----LKGS-----FTEEDRLMPSSPYSATKAASDMLVLGWART 165
R HISTDEVYGD+ ++ S FTE PSSPYSA+KA+SD LV W RT
Sbjct: 120 SFRFHHISTDEVYGDLPHPDEVENSVTLPLFTETTAYAPSSPYSASKASSDHLVRAWRRT 179
Query: 166 YGLNASITRCTNNYGPYQFPEKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRAIE 225
YGL +T C+NNYGPY FPEKLIP I+ A G +PIYG G +RDWLYVEDH RA+
Sbjct: 180 YGLPTIVTNCSNNYGPYHFPEKLIPLVILNALEGKPLPIYGKGDQIRDWLYVEDHARALH 239
Query: 226 AVLLKGEAREIYNISAGEERTNLEVVRTILRIMDK-------DESLIEFVEDRPGHDIRY 278
V+ +G+A E YNI E+ NL+VV TI ++D+ I +V DRPGHD RY
Sbjct: 240 MVVTEGKAGETYNIGGHNEKKNLDVVFTICDLLDEIVPKATSYREQITYVADRPGHDRRY 299
Query: 279 SL 280
++
Sbjct: 300 AI 301
>gb|AAG09484.1|AF279635_1 (AF279635) dTDP-D-glucose-4,6-dehydratase [Salmonella enterica]
Length = 301
Score = 271 bits (686), Expect = 8e-72
Identities = 144/302 (47%), Positives = 184/302 (60%), Gaps = 28/302 (9%)
Query: 6 TGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDVADFEL 65
TGG GFIGS IR+I++ D V+N+DKLTY N +L DI + RY F D+ D
Sbjct: 1 TGGAGFIGSAVIRHIIKNTQD-TVVNIDKLTYAGNLESLSDISESNRYNFELADICDSAE 59
Query: 66 VRELIKKV--DAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRK--------ENP 115
+ + ++ DA++H AAESHVDRSI+ P F+ +N++GTY LLE RK +
Sbjct: 60 ITRIFEQYQPDAVMHLAAESHVDRSITGPAAFIETNIVGTYVLLEVARKYWSALGEDKKN 119
Query: 116 GVRLVHISTDEVYGD----------ILKGSFTEEDRLMPSSPYSATKAASDMLVLGWART 165
R HISTDEVYGD + FTE PSSPYSA+KA+SD LV W RT
Sbjct: 120 SFRFHHISTDEVYGDLPHPDEVDNSVTLSLFTETTSYAPSSPYSASKASSDHLVRAWRRT 179
Query: 166 YGLNASITRCTNNYGPYQFPEKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRAIE 225
YGL +T C+NNYGPY FPEKLIP I+ A G +PIYG G +RDWLYVEDH RA+
Sbjct: 180 YGLPTIVTNCSNNYGPYHFPEKLIPLVILNALEGKSLPIYGKGDQIRDWLYVEDHARALH 239
Query: 226 AVLLKGEAREIYNISAGEERTNLEVVRTILRIMDK-------DESLIEFVEDRPGHDIRY 278
V+ +G+A E YNI E+ NL+VV TI ++D+ I +V DRPGHD RY
Sbjct: 240 IVVTEGKAGETYNIGGHNEKKNLDVVFTICDLLDEIVPKATSYREQITYVADRPGHDRRY 299
Query: 279 SL 280
++
Sbjct: 300 AI 301
>gb|AAG09475.1|AF279626_1 (AF279626) dTDP-D-glucose-4,6-dehydratase [Salmonella enterica]
>gi|9957771|gb|AAG09476.1|AF279627_1 (AF279627)
dTDP-D-glucose-4,6-dehydratase [Salmonella enterica]
Length = 301
Score = 271 bits (685), Expect = 1e-71
Identities = 146/302 (48%), Positives = 186/302 (61%), Gaps = 28/302 (9%)
Query: 6 TGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDVADFEL 65
TGG GFIGS +R+I+ K+ V+N+DKLTY N +L +I + RY F D+ D
Sbjct: 1 TGGAGFIGSAVVRHII-KNTQNTVVNIDKLTYAGNLESLSEISESNRYIFEHADICDSAE 59
Query: 66 VRELIKKV--DAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRK--------ENP 115
+ + ++ DA++H AAESHVDRSI+ P F+ +N++GTY LLEA RK +
Sbjct: 60 ITRIFEQYQPDAVMHLAAESHVDRSITGPAAFIETNIVGTYVLLEAARKYWSALGEDKKN 119
Query: 116 GVRLVHISTDEVYGDILKGS----------FTEEDRLMPSSPYSATKAASDMLVLGWART 165
R HISTDEVYGD+ FTE PSSPYSA+KA+SD LV W RT
Sbjct: 120 SFRFHHISTDEVYGDLPHPDEVDNIVTLPLFTETTAYAPSSPYSASKASSDHLVRAWKRT 179
Query: 166 YGLNASITRCTNNYGPYQFPEKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRAIE 225
YGL +T C+NNYGPY FPEKLIP I+ A G +PIYG G +RDWLYVEDH RA+
Sbjct: 180 YGLPTIVTNCSNNYGPYHFPEKLIPLVILNALEGKPLPIYGKGDQIRDWLYVEDHARALH 239
Query: 226 AVLLKGEAREIYNISAGEERTNLEVVRTILRIMD----KDESL---IEFVEDRPGHDIRY 278
V+ +GE E YNI E+ NLEVV TI ++D K+ S I +V DRPGHD RY
Sbjct: 240 IVVTQGEVGETYNIGGHNEKKNLEVVHTICDLLDEIVPKEGSYRDQITYVGDRPGHDRRY 299
Query: 279 SL 280
++
Sbjct: 300 AI 301
>gb|AAG09492.1|AF279643_1 (AF279643) dTDP-D-glucose-4,6-dehydratase [Salmonella enterica]
>gi|9957805|gb|AAG09493.1|AF279644_1 (AF279644)
dTDP-D-glucose-4,6-dehydratase [Salmonella enterica]
Length = 301
Score = 270 bits (684), Expect = 1e-71
Identities = 144/302 (47%), Positives = 187/302 (61%), Gaps = 28/302 (9%)
Query: 6 TGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDVADFEL 65
TGG GFIGS +R+I++ D V+N+DKLTY N +L DI + RY F D+ D
Sbjct: 1 TGGAGFIGSAVVRHIIKNTQD-TVVNIDKLTYAGNLESLSDISESNRYNFEHSDICDSAE 59
Query: 66 VRELIKKV--DAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRK--------ENP 115
+ + ++ DA++H AAESHVDRSI+ P F+ +N++GTY LLE RK +
Sbjct: 60 ITRIFEQYQPDAVMHLAAESHVDRSITGPAAFIETNIVGTYVLLEVARKYWSALGEDKKN 119
Query: 116 GVRLVHISTDEVYGDI-----LKGS-----FTEEDRLMPSSPYSATKAASDMLVLGWART 165
R HISTDEVYGD+ ++ S FTE PSSPYSA+KA+SD LV W RT
Sbjct: 120 NFRFHHISTDEVYGDLPHPDEVENSVTLPLFTETTAYAPSSPYSASKASSDHLVRAWRRT 179
Query: 166 YGLNASITRCTNNYGPYQFPEKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRAIE 225
YGL +T C+NNYGPY FPEKLIP I+ A G +PIYG G +RDWLYVEDH RA+
Sbjct: 180 YGLPTIVTNCSNNYGPYHFPEKLIPLVILNALEGKPLPIYGKGDQIRDWLYVEDHARALH 239
Query: 226 AVLLKGEAREIYNISAGEERTNLEVVRTILRIMDK-------DESLIEFVEDRPGHDIRY 278
V+ +G+A E YNI E+ NL+VV TI ++D+ I +V DRPGHD RY
Sbjct: 240 MVVTEGKAGETYNIGGHNEKKNLDVVFTICDLLDEIVPKATSYREQITYVADRPGHDRRY 299
Query: 279 SL 280
++
Sbjct: 300 AI 301
>gb|AAG09494.1|AF279645_1 (AF279645) dTDP-D-glucose-4,6-dehydratase [Salmonella enterica]
Length = 301
Score = 270 bits (684), Expect = 1e-71
Identities = 144/302 (47%), Positives = 187/302 (61%), Gaps = 28/302 (9%)
Query: 6 TGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDVADFEL 65
TGG GFIGS +R+I++ D V+N+DKLTY N +L DI + RY F D+ D
Sbjct: 1 TGGAGFIGSAVVRHIIKNTQD-TVVNIDKLTYAGNLESLSDISESNRYNFEHADICDSAE 59
Query: 66 VRELIKKV--DAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRK--------ENP 115
+ + ++ DA++H AAESHVDRSI+ P F+ +N++GTY LLE RK +
Sbjct: 60 ITRIFEQYQPDAVMHLAAESHVDRSITGPAAFIETNIVGTYVLLEVARKYWSALGEDKKN 119
Query: 116 GVRLVHISTDEVYGDI-----LKGS-----FTEEDRLMPSSPYSATKAASDMLVLGWART 165
R HISTDEVYGD+ ++ S FTE PSSPYSA+KA+SD LV W RT
Sbjct: 120 NFRFHHISTDEVYGDLPHPDEVENSVTLPLFTETTAYAPSSPYSASKASSDHLVRAWRRT 179
Query: 166 YGLNASITRCTNNYGPYQFPEKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRAIE 225
YGL +T C+NNYGPY FPEKLIP I+ A G +PIYG G +RDWLYVEDH RA+
Sbjct: 180 YGLPTIVTNCSNNYGPYHFPEKLIPLVILNALEGKPLPIYGKGDQIRDWLYVEDHARALH 239
Query: 226 AVLLKGEAREIYNISAGEERTNLEVVRTILRIMDK-------DESLIEFVEDRPGHDIRY 278
V+ +G+A E YNI E+ NL+VV TI ++D+ I +V DRPGHD RY
Sbjct: 240 MVVTEGKAGETYNIGGHNEKKNLDVVFTICDLLDEIVPKATSYREQITYVADRPGHDRRY 299
Query: 279 SL 280
++
Sbjct: 300 AI 301
>gb|AAG09495.1|AF279646_1 (AF279646) dTDP-D-glucose-4,6-dehydratase [Salmonella enterica]
Length = 301
Score = 270 bits (684), Expect = 1e-71
Identities = 144/302 (47%), Positives = 187/302 (61%), Gaps = 28/302 (9%)
Query: 6 TGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDVADFEL 65
TGG GFIGS +R+I++ D V+N+DKLTY N +L DI + RY F D+ D
Sbjct: 1 TGGAGFIGSAVVRHIIKNTQD-TVVNIDKLTYAGNLESLSDISESNRYNFELADICDSAE 59
Query: 66 VRELIKKV--DAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRK--------ENP 115
+ + ++ DA++H AAESHVDRSI+ P F+ +N++GTY LLE RK +
Sbjct: 60 ITRIFEQYQPDAVMHLAAESHVDRSITGPAAFIETNIVGTYVLLEVARKYWSALGEDKKN 119
Query: 116 GVRLVHISTDEVYGDI-----LKGS-----FTEEDRLMPSSPYSATKAASDMLVLGWART 165
R HISTDEVYGD+ ++ S FTE PSSPYSA+KA+SD LV W RT
Sbjct: 120 NFRFHHISTDEVYGDLPHPDEVENSVTLPLFTETTAYAPSSPYSASKASSDHLVRAWRRT 179
Query: 166 YGLNASITRCTNNYGPYQFPEKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRAIE 225
YGL +T C+NNYGPY FPEKLIP I+ A G +PIYG G +RDWLYVEDH RA+
Sbjct: 180 YGLPTIVTNCSNNYGPYHFPEKLIPLVILNALEGKSLPIYGKGDQIRDWLYVEDHARALH 239
Query: 226 AVLLKGEAREIYNISAGEERTNLEVVRTILRIMDK-------DESLIEFVEDRPGHDIRY 278
V+ +G+A E YNI E+ NL+VV TI ++D+ I +V DRPGHD RY
Sbjct: 240 MVVTEGKAGETYNIGGHNEKKNLDVVFTICDLLDEIVPKATSYREQITYVADRPGHDRRY 299
Query: 279 SL 280
++
Sbjct: 300 AI 301
>gi|7657641 dTDP-D-glucose 4,6-dehydratase [Homo sapiens]
>gi|4128133|emb|CAA06840.1| (AJ006068) dTDP-D-glucose
4,6-dehydratase [Homo sapiens]
>gi|5737699|gb|AAD50061.1|AF048686_1 (AF048686)
dTDP-glucose 4,6-dehydratase like protein [Homo sapiens]
Length = 350
Score = 243 bits (614), Expect = 2e-63
Identities = 132/335 (39%), Positives = 203/335 (60%), Gaps = 12/335 (3%)
Query: 2 RILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDVA 61
R+LVTGG GFI S+ I ++E + ++ +INLDKL Y ++ NL+ I + Y F++GD+
Sbjct: 19 RVLVTGGAGFIASHMIVSLVEDYPNYMIINLDKLDYCASLKNLETISNKQNYKFIQGDIC 78
Query: 62 DFELVRELIK--KVDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKENPGVRL 119
D V+ L + K+D ++HFAA++HVD S F + NV GT+ L+ A + +
Sbjct: 79 DSHFVKLLFETEKIDIVLHFAAQTHVDLSFVRAFEFTYVNVYGTHVLVSAAHEARVE-KF 137
Query: 120 VHISTDEVYGDILKGSFTEEDRLMPSSPYSATKAASDMLVLGWARTYGLNASITRCTNNY 179
+++STDEVYG L F E P++PY+++KAA++ V + Y ITR +N Y
Sbjct: 138 IYVSTDEVYGGSLDKEFDESSPKQPTNPYASSKAAAECFVQSYWEQYKFPVVITRSSNVY 197
Query: 180 GPYQFPEKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRAIEAVLLKGEAREIYNI 239
GP+Q+PEK+IPK I + K I+G+G R++LY D V A VL KG+ EIYNI
Sbjct: 198 GPHQYPEKVIPKFISLLQHNRKCCIHGSGLQTRNFLYATDVVEAFLTVLKKGKPGEIYNI 257
Query: 240 SAGEERTNLEVVRTILRIMDKD------ESLIEFVEDRPGHDIRYSLDSWKIIRELKWRP 293
E + +++ + +++++ + E+ +++V DRP +D+RY + S K I L WRP
Sbjct: 258 GTNFEMSVVQLAKELIQLIKETNSESEMENWVDYVNDRPTNDMRYPMKSEK-IHGLGWRP 316
Query: 294 KYRFEEGIKKTVEWYLENEWWWKPLINERVLHPTP 328
K ++EGIKKT+EWY EN WK + E+ L P P
Sbjct: 317 KVPWKEGIKKTIEWYRENFHNWKNV--EKALEPFP 349
>emb|CAC01395.1| (AJ131360) dTDP-glucose 4,6-dehydratase [Campylobacter jejuni]
Length = 233
Score = 230 bits (580), Expect = 2e-59
Identities = 117/233 (50%), Positives = 161/233 (68%), Gaps = 14/233 (6%)
Query: 1 MRILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDV 60
M ILVTGG GFIGSNF+ Y EK+ + ++INLD LTY S+ +NL ++++P Y F++GD+
Sbjct: 1 MYILVTGGAGFIGSNFLLYFFEKNPNAKIINLDFLTYASDISNLNKLKNNPNYVFIQGDI 60
Query: 61 ADFELVRELIKK--VDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKE---NP 115
+D LV E+ K ++A+++FAAESHVD SI +PD F+ +N+ GT+ LL + K P
Sbjct: 61 SDVSLVGEIFSKYKINAVINFAAESHVDNSIKNPDIFIKTNIYGTWNLLNSAYKTWFLEP 120
Query: 116 GVR--------LVHISTDEVYGDILK-GSFTEEDRLMPSSPYSATKAASDMLVLGWARTY 166
++ ISTDEVYG + + G FTE++ P+SPYSA+KA++DMLV + TY
Sbjct: 121 FLKKDEFKQSFFYQISTDEVYGSLGENGKFTEDNAYAPNSPYSASKASADMLVRSYHHTY 180
Query: 167 GLNASITRCTNNYGPYQFPEKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVED 219
GLNA I+ C+NNYGP+Q EKLIP I A +PIYG GKN+RDWLYV+D
Sbjct: 181 GLNAVISNCSNNYGPFQHDEKLIPTIIRNALNETPIPIYGDGKNIRDWLYVKD 233
>pir||T16444 hypothetical protein F53B1.4 - Caenorhabditis elegans
>gi|1072251|gb|AAB52650.1| (U40953) Similar to thymidine
diphosphoglucose 4,6-dehydratase; coded for by C.
elegans cDNA CEESG39R [Caenorhabditis elegans]
Length = 342
Score = 219 bits (553), Expect = 3e-56
Identities = 125/322 (38%), Positives = 192/322 (58%), Gaps = 14/322 (4%)
Query: 3 ILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANL-KDIQDDPRYTFVKGDVA 61
+L+TGG GFIGSN+I + K + + IN DKL +G++P ++ K+I++ PRY FV+ +
Sbjct: 11 VLITGGCGFIGSNYINFTFNKWKNTKFINYDKLAFGASPLHVEKEIRESPRYKFVEAALE 70
Query: 62 DFELVRELIKK--VDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAI-RKENPGVR 118
D + + +++ VD ++HFAA +HVD S S + N+I T TLLE+I GV+
Sbjct: 71 DQPTLIKTLQENEVDMVIHFAAITHVDESYSDRIGTIQDNIISTTTLLESIVNSPYKGVK 130
Query: 119 -LVHISTDEVYGDILKGSFTEEDRLM---PSSPYSATKAASDMLVLGWARTYGLNASITR 174
LVHISTDEVYGD + + + + P++PY+A+KAA +M++ + +Y L + R
Sbjct: 131 KLVHISTDEVYGDSFEDTTPKSESASLPNPTNPYAASKAACEMVIRSYWHSYKLPYVMVR 190
Query: 175 CTNNYGPYQFPEKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRAIEAVLLKGEAR 234
N YGP Q KLIPK A G P+ G G + R W+YVED AI V L+G
Sbjct: 191 MNNVYGPRQIHTKLIPKFTKLALDGKPYPLMGDGLHTRSWMYVEDCSEAITRVALEGTLG 250
Query: 235 EIYNISAGEERTNLEVVR----TILRIMDKDESLIEF--VEDRPGHDIRYSLDSWKIIRE 288
EIYNI E TN+E+ + T+ ++++++ + F + DRP HD RY +D KI
Sbjct: 251 EIYNIGTDFEMTNIELTKMIHFTVSKLLNREPTAPTFAPIPDRPYHDRRYYIDFSKIRNA 310
Query: 289 LKWRPKYRFEEGIKKTVEWYLE 310
+ W+ F EG+ KT+++Y++
Sbjct: 311 MGWQCTTPFSEGLMKTIDYYVK 332
>gb|AAK41933.1| dTDP-Glucose 4,6-dehydratase (rfbB-2) [Sulfolobus solfataricus]
Length = 350
Score = 216 bits (545), Expect = 3e-55
Identities = 115/253 (45%), Positives = 158/253 (61%), Gaps = 15/253 (5%)
Query: 82 ESH--VDRSISSPDNFLHSNVIGTYTLLEAIRKENPGVRLVHISTDEVYGDILKGSFTEE 139
+SH VDRSI P +F+ +NV GT +LEA R+ N + VHISTDEVYG+ E
Sbjct: 102 DSHTDVDRSIYKPQDFVSTNVFGTVNVLEAARRYN--FKYVHISTDEVYGEECS---DEN 156
Query: 140 DRLMPSSPYSATKAASDMLVLGWARTYGLNASITRCTNNYGPYQFPEKLIPKTIIRAKMG 199
+ PSSPYSA+KA++D+ V + +TY + A I R +NNYGP QFPEK IPK IIR +G
Sbjct: 157 SSVNPSSPYSASKASADLFVKSYIKTYNVEAIIVRPSNNYGPRQFPEKFIPKAIIRTILG 216
Query: 200 LKVPIYGTGKNVRDWLYVEDHVRAIEAVLLKGEAR-EIYNISAGEERTNLEVVRTILRIM 258
+ VPIYG G+ RDW+YVED R I ++ E R E+YNI G N++++R + R++
Sbjct: 217 IYVPIYGNGEQERDWIYVEDTARVIFDLIRSAEWRGEVYNIPGGYRVKNIQLIRLLERVI 276
Query: 259 DKDESLIEFVEDRPGHDIRYSLDSWKIIRELKWRPKYRFEEGIKKTVEWYLENEWWWKPL 318
K E +++V DRPGHD RY + + K+ P EEG++KT +WY N WWW L
Sbjct: 277 -KKEIKVKYVSDRPGHDRRYCMINTKL--NYTTTP---LEEGLRKTYDWYANNNWWWSSL 330
Query: 319 INERVL-HPTPWK 330
+N+ PW+
Sbjct: 331 VNDEFFKSDEPWR 343
>emb|CAA75866.1| (Y15903) dTDP-glucose-4,6-dehydratase [Streptococcus agalactiae]
Length = 194
Score = 193 bits (485), Expect = 3e-48
Identities = 86/174 (49%), Positives = 118/174 (67%), Gaps = 1/174 (0%)
Query: 144 PSSPYSATKAASDMLVLGWARTYGLNASITRCTNNYGPYQFPEKLIPKTIIRAKMGLKVP 203
PSSPYS+TKAASD++V W R++G+ A+I+ C+NNYGPYQ EK IP+ I G+K
Sbjct: 3 PSSPYSSTKAASDLIVKAWVRSFGVKATISNCSNNYGPYQHIEKFIPRQITNILAGIKPK 62
Query: 204 IYGTGKNVRDWLYVEDHVRAIEAVLLKGEAREIYNISAGEERTNLEVVRTILRIMDKDES 263
+YG GKNVRDW++ DH + A+L KG E Y I A E+ N EV+ IL M + +
Sbjct: 63 LYGEGKNVRDWIHTNDHSTGVWAILTKGRIGETYLIGADGEKNNKEVLELILEKMGQPKD 122
Query: 264 LIEFVEDRPGHDIRYSLDSWKIIRELKWRPKY-RFEEGIKKTVEWYLENEWWWK 316
+ V DR GHD+RY++DS K+ EL W P++ F EG+++T++WY ENE WWK
Sbjct: 123 AYDHVTDRAGHDLRYAIDSTKLREELGWEPQFTNFSEGLEETIKWYTENETWWK 176
>pir||T15370 hypothetical protein C01F1.3 - Caenorhabditis elegans
>gi|1330395|gb|AAB00715.1| (U58761) coded for by C.
elegans cDNA yk62h9.5; coded for by C. elegans cDNA
yk62h9.3; similarity to DTDP-glucose 4,6-Dehydratases
[Caenorhabditis elegans]
Length = 631
Score = 186 bits (467), Expect = 4e-46
Identities = 106/316 (33%), Positives = 169/316 (52%), Gaps = 13/316 (4%)
Query: 3 ILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKD-IQDDPRYTFVKGDVA 61
+++TGG GFIGSNF+ YI + +N+DKL S+ N+ + +++ PRY V D+
Sbjct: 8 VVITGGCGFIGSNFVNYIHDAWPTCNFVNIDKLILNSDTQNVAESVRNSPRYKLVLTDIK 67
Query: 62 DFELVRELIKK--VDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKENPGVRL 119
+ + + ++ +D ++HFAA+ R + + +NV+ LE +R R
Sbjct: 68 NEAAILNVFEQNEIDTVIHFAADCTSTRCYNETAEAVQNNVLSFIQFLETVRTYGKIKRF 127
Query: 120 VHISTDEVYGDI----LKGSFTEEDRLMPSSPYSATKAASDMLVLGWARTYGLNASITRC 175
VHISTDEVYGD + E RL+P +PY+ATK A + V + Y L R
Sbjct: 128 VHISTDEVYGDSDLSENEQGKVEFSRLVPGNPYAATKIAGEAYVRAYQTQYNLPIVTARM 187
Query: 176 TNNYGPYQFPEKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRAIEAVLLKGEARE 235
N YGP Q+ K++P+ I AK+ + I G+GK +R WL+V+D ++AV KGE E
Sbjct: 188 NNIYGPNQWDVKVVPRFIEIAKVRGEYTIQGSGKQLRSWLFVDDASAGLKAVCEKGELHE 247
Query: 236 IYNISAGEERTNLEVVRTILRIMD------KDESLIEFVEDRPGHDIRYSLDSWKIIREL 289
IYN+ E+ ++ +TI +D + + + DRP +D+RY + K +L
Sbjct: 248 IYNLGTYYEKNVADLAKTIQEEVDLQLGRAHEPPKYKSIPDRPYNDLRYLISIEKAKNDL 307
Query: 290 KWRPKYRFEEGIKKTV 305
W P F++G++ TV
Sbjct: 308 GWEPTTSFDDGMRHTV 323
>gb|AAF31493.1|AF071521_1 (AF071521) putative TDP-glucose dehydratase [Streptomyces noursei]
Length = 179
Score = 179 bits (449), Expect = 5e-44
Identities = 94/180 (52%), Positives = 124/180 (68%), Gaps = 5/180 (2%)
Query: 1 MRILVTGGMGFIGSNFIRYILE----KHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFV 56
MR+LVTGG GFIGS F+R +L + +V LDKLTY ANL + D P YTFV
Sbjct: 1 MRLLVTGGAGFIGSEFVRSLLSITDSSTHGIQVTVLDKLTYAGVAANLDPVVDHPGYTFV 60
Query: 57 KGDVADFELVRELIKKVDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKENPG 116
GD+ D LV +++ DA+VHFAAESHVDRSI+ + F+ +NV+GT LL+A + G
Sbjct: 61 HGDICDARLVDQVMAGHDAVVHFAAESHVDRSIAGAEPFVMTNVMGTQLLLDAAVRHRIG 120
Query: 117 VRLVHISTDEVYGDILKGSFTEEDRLMPSSPYSATKAASDMLVLGWARTYGLNASITRCT 176
R VH+STDEVYG I GS+TE+ + P+SPY+A+KA SD+L L + RTYGL+ +TRC+
Sbjct: 121 -RFVHVSTDEVYGSISTGSWTEDCPVEPNSPYAASKAGSDLLALAYHRTYGLDVVVTRCS 179
>pir||D70696 probable dtdp-glucose 4 - Mycobacterium tuberculosis (strain H37RV)
>gi|1552867|emb|CAB02463.1| (Z80343) epiB [Mycobacterium
tuberculosis]
Length = 326
Score = 159 bits (397), Expect = 6e-38
Identities = 107/318 (33%), Positives = 173/318 (53%), Gaps = 23/318 (7%)
Query: 1 MRILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDV 60
M ILVTGG GF GS+ +L + W + LDK + + N++ + R F+ G V
Sbjct: 1 MEILVTGGAGFQGSHLTESLLA-NGHWVTV-LDKSSRNA-VRNMQGFRSHDRAAFISGSV 57
Query: 61 ADFELVRELIKKVDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKENPGVRLV 120
D + + ++ + H AA +VD+S+ P++FL +NV+GTY +LEA+R+ RL+
Sbjct: 58 TDGQTIDRAVRDHHVVFHLAAHVNVDQSLGDPESFLETNVMGTYRVLEAVRRYRN--RLI 115
Query: 121 HISTDEVYGD---ILKGS-FTEEDRLMPSSPYSATKAASDMLVLGWARTYGLNASITRCT 176
++ST EVYGD + +G E L P+SPY A+KAA+D L + R+YGL+ +I R
Sbjct: 116 YVSTCEVYGDGHNLKEGERLDEHAELKPNSPYGASKAAADRLCYSYFRSYGLDVTIVRPF 175
Query: 177 NNYGPYQFPEK---LIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRAIEAVL----L 229
N +G Q + LIP+ + + G + I+G G RD+LYV D V A VL L
Sbjct: 176 NIFGVRQKAGRFGALIPRLVRQGINGEGLTIFGAGSATRDYLYVSDIVGAYNLVLRTPTL 235
Query: 230 KGEAREIYNISAGEERTNLEVVRTILRIMDKDESLIEFVEDRPGHDIRYSLDSWKIIREL 289
+G+A N ++G++ ++V + DK + IE + RPG R+ D + + +
Sbjct: 236 RGQA---INFASGKDTRVRDIVE---YVADKFGARIEHRDARPGEVQRFPADI-SLAKSI 288
Query: 290 KWRPKYRFEEGIKKTVEW 307
++P+ +GI + + W
Sbjct: 289 GFQPQVEIWDGIDRYINW 306
>pir||A71183 probable UDP-glucose 4-epimerase - Pyrococcus horikoshii
>gi|3258173|dbj|BAA30856.1| (AP000007) 306aa long
hypothetical UDP-glucose 4-epimerase [Pyrococcus
horikoshii]
Length = 306
Score = 152 bits (381), Expect = 4e-36
Identities = 105/309 (33%), Positives = 168/309 (53%), Gaps = 16/309 (5%)
Query: 3 ILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDVAD 62
I++TGG GFIGS+ + +++ +VI +D L G +++I + + F++ DV D
Sbjct: 6 IVITGGAGFIGSHLAEALKDEN---DVIIIDNLYSG----RIENIPEGVK--FIRADVRD 56
Query: 63 FELVRELIKKVDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKENPGVRLVHI 122
+E + E+I + D + H AA+ V SI P NVIGT +L A+ + + +L+
Sbjct: 57 YESIAEVISEADYVFHEAAQISVKESIEDPVFTEEVNVIGTINVLRALSQGDG--KLIFA 114
Query: 123 STDEVYGDILKGSFTEEDRLMPSSPYSATKAASDMLVLGWARTYGLNASITRCTNNYGPY 182
S+ VYG+ + TE+ P SPY TK A++ + YG+ I R N YGP
Sbjct: 115 SSAAVYGEPKELPITEDTLTNPISPYGITKLAAEHYCRVYQSLYGIPVVILRYFNVYGPR 174
Query: 183 QFP--EKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRAIEAVLLKGEAR-EIYNI 239
Q +I + RA G + I+G GK RD++YV+D V A V K A I+N+
Sbjct: 175 QSSAYAGVISIFLERAIKGEPLIIFGDGKQTRDFIYVKDVVEANILVAKKRSANGRIFNV 234
Query: 240 SAGEERTNLEVVRTILRIMDKDESLIEFVEDRPGHDIRYSLDSWKIIRELKWRPKYRFEE 299
+ G+E T LE+ I+ + S++ F RPG DIR S+ + I++L ++P+Y EE
Sbjct: 235 ATGKETTILELAMKIIDMTSSSSSIL-FYPPRPG-DIRRSVAKIERIKKLGFKPRYSLEE 292
Query: 300 GIKKTVEWY 308
G+K+T +W+
Sbjct: 293 GLKETFKWF 301
>gb|AAA65538.1| (L20496) UDP-N-acetyl-D-glucosamine-2-epimerase [Neisseria
meningitidis]
Length = 176
Score = 150 bits (375), Expect = 2e-35
Identities = 85/175 (48%), Positives = 112/175 (63%), Gaps = 13/175 (7%)
Query: 2 RILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDVA 61
+ILVTGG GFIGS +R+I+ D V+N+DKLTY N +L ++ D+PRY F + D+
Sbjct: 3 KILVTGGAGFIGSAVVRHIIRNTRD-AVVNVDKLTYAGNLESLTEVADNPRYAFEQVDIC 61
Query: 62 D-FELVRELIK-KVDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIR-------- 111
D EL R + + DA++H AAESHVDRSI S F+ +N++GT+ LLEA R
Sbjct: 62 DRAELDRVFAQYRPDAVMHLAAESHVDRSIGSAGEFIQTNIVGTFNLLEAARAYWQQMPS 121
Query: 112 KENPGVRLVHISTDEVYGDI--LKGSFTEEDRLMPSSPYSATKAASDMLVLGWAR 164
+++ R HISTDEVYGD+ FTE PSSPYSA+KA+SD LV W R
Sbjct: 122 EQHEAFRFHHISTDEVYGDLGGTDDLFTETAPYAPSSPYSASKASSDHLVRAWLR 176
>pir||D75143 udp-glucose 4-epimerase (gale-1) PAB2145 - Pyrococcus abyssi
(strain Orsay) >gi|5457737|emb|CAB49227.1| (AJ248284)
UDP-glucose 4-epimerase (galE-1) [Pyrococcus abyssi]
Length = 307
Score = 149 bits (373), Expect = 4e-35
Identities = 106/312 (33%), Positives = 165/312 (51%), Gaps = 22/312 (7%)
Query: 3 ILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDVAD 62
I+VTGG GFIGS+ I L++ ND V+ +D L Y P N+ + F++ DV D
Sbjct: 6 IVVTGGAGFIGSH-IAEALKEEND--VVVIDNL-YSGKPENVPE-----GVKFIEADVRD 56
Query: 63 FELVRELIKKVDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKENPGVRLVHI 122
+E + E++ D + H AA+ V+ S+ P NVIGT +L A+ + N +L+
Sbjct: 57 YESIAEIVSSADYVFHEAAQISVEESVKDPVFTEEVNVIGTINILRALSEGNG--KLIFA 114
Query: 123 STDEVYGDILKGSFTEEDRLMPSSPYSATKAASDMLVLGWARTYGLNASITRCTNNYGPY 182
S+ VYG+ E+ L P SPY +K + + + + YG+ I R N YGP
Sbjct: 115 SSAAVYGEPTSLPIREDHPLNPISPYGVSKVSGEHYCKVFYQLYGVPTVILRYFNVYGPR 174
Query: 183 QFP--EKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRAIEAVLLKGEAR----EI 236
Q +I + RA G + I+G GK RD++YV+D +EA +L E R E
Sbjct: 175 QSSAYAGVISIFMERALRGEPLVIFGDGKQSRDFVYVKD---VVEANILVAEKRRAEGET 231
Query: 237 YNISAGEERTNLEVVRTILRIMDKDESLIEFVEDRPGHDIRYSLDSWKIIRELKWRPKYR 296
+N+ G E T +E+ I+ + S I F + RPG DIR S+ + I++L ++P+Y
Sbjct: 232 FNVGTGRETTIIELAMKIIE-LSSTSSQILFSKPRPG-DIRRSVADIEKIKKLGFKPRYS 289
Query: 297 FEEGIKKTVEWY 308
EEG+ +T +W+
Sbjct: 290 LEEGLLETWKWF 301
>pir||D81275 probable nucleotide sugar dehydratase Cj1319 [imported] -
Campylobacter jejuni (strain NCTC 11168)
>gi|6968753|emb|CAB73746.1| (AL139078) putative
nucleotide sugar dehydratase [Campylobacter jejuni]
Length = 323
Score = 148 bits (371), Expect = 7e-35
Identities = 104/327 (31%), Positives = 163/327 (49%), Gaps = 36/327 (11%)
Query: 3 ILVTGGMGFIGSNFIRYILEK------------HNDWEVINLDKLTYGSNPANLKDIQDD 50
ILVTG GFIGS+ +++K N W +L+K + LKD++
Sbjct: 4 ILVTGADGFIGSHLCESLVKKGFKVRALSQYNSFNFWG--HLEKSPF------LKDME-- 53
Query: 51 PRYTFVKGDVADFELVRELIKKVDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAI 110
+ GD+ D ++ K +DAI H A + S ++P +++ +NV GT +LEA
Sbjct: 54 ----VISGDLRDSFFCEKITKNIDAIFHLGALIAIPYSYTAPQSYVDTNVNGTLNMLEAA 109
Query: 111 RKENPGVRLVHISTDEVYGDILKGSFTEEDRLMPSSPYSATKAASDMLVLGWARTYGLNA 170
+K N +H ST EVYG E+ L P SPYSA+K A+DM+ L + ++ LN
Sbjct: 110 KK-NEISHFIHTSTSEVYGTAFYVPIDEKHPLQPQSPYSASKIAADMMALSYYNSFNLNV 168
Query: 171 SITRCTNNYGPYQFPEKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRAIEAVLLK 230
+I R N YGP Q +IP I + G K G RD +V D ++L
Sbjct: 169 NIARPFNTYGPRQSARAIIPTIITQILSGAKEIKLGDLSPKRDLNFVLDTCEGFISLLNL 228
Query: 231 GEAREIYNISAGEERTNLEVVRTILRIMDKDESLIEFVED----RPGHD--IRYSLDSWK 284
E+YNI +G E + EV+ I +I+D S ++ ++D RP + R D+ K
Sbjct: 229 KHFGEVYNIGSGVEYSMQEVLDLIQKILD---SKVKIIQDEQRLRPKNSEVFRLCCDANK 285
Query: 285 IIRELKWRPKYRFEEGIKKTVEWYLEN 311
+ + W+ K EEG+++++E++ EN
Sbjct: 286 LKKATNWQSKISLEEGLRQSIEYFKEN 312
>gb|AAG18701.1| (AE004975) UDP-glucose 4-epimerase; GalE2 [Halobacterium sp. NRC-1]
Length = 328
Score = 148 bits (369), Expect = 1e-34
Identities = 110/332 (33%), Positives = 154/332 (46%), Gaps = 16/332 (4%)
Query: 1 MRILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPA--------NLKDIQDDPR 52
MRILVTGG GFIG + + + +D V++ Y + NL D D
Sbjct: 1 MRILVTGGAGFIGGHLAERFVSRGHDVVVLDNFDPFYDTRIKDHTVEVCQNLAD-DGDGS 59
Query: 53 YTFVKGDVADFELVRELIKKVDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRK 112
Y V+GDV D ELV EL+ VD + H A ++ V S+ P + NV GT +L+A RK
Sbjct: 60 YRLVEGDVRDAELVEELVADVDYVYHQAGQAGVRPSVEDPRKYNEVNVDGTLNVLDAARK 119
Query: 113 ENPGVRLVHISTDEVYGDILKGSFTEEDRLMPSSPYSATKAASDMLVLGWARTYGLNASI 172
R+V S+ VYG + E P SPY A+K A++ V ++ Y L
Sbjct: 120 TEIE-RVVFASSSSVYGKPEYLPYDEVHPTTPVSPYGASKLAAERYVCAYSEVYDLPTVA 178
Query: 173 TRCTNNYGPYQFPEKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRAIEAVLLKGE 232
R YGP P I + R G +YG G RD+ Y+ED V A EA+L
Sbjct: 179 LRYFTVYGPRMRPNMAISNFVSRCLNGEPPVVYGDGTQTRDFTYIEDVVDANEALLTDDA 238
Query: 233 A-REIYNISAGEERTNLEVVRTILRIMDK--DESLIEFVEDRPGHDIRYSLDSWKIIREL 289
A E+ NI + + N++++ I D+ E IEF E D K L
Sbjct: 239 ADGEVLNIGSTD---NIDILTLAEEIRDQVAPELDIEFAERFEADAEHTHADISKANELL 295
Query: 290 KWRPKYRFEEGIKKTVEWYLENEWWWKPLINE 321
+ P EG+++ VEWY N W++PL+ E
Sbjct: 296 GYEPSRTIREGVQEFVEWYRANRDWYEPLVLE 327
>sp|Q58455|YA55_METJA HYPOTHETICAL PROTEIN MJ1055 >gi|2127791|pir||F64431 capsular
polysaccharide biosynthesis protein I homolog -
Methanococcus jannaschii >gi|1591707|gb|AAB99057.1|
(U67548) capsular polysaccharide biosynthesis protein I
[Methanococcus jannaschii]
Length = 326
Score = 145 bits (363), Expect = 6e-34
Identities = 96/320 (30%), Positives = 171/320 (53%), Gaps = 11/320 (3%)
Query: 3 ILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDD-----PRYTFVK 57
ILVTG GFIG + +Y+++ + D +VI +D L NP LK+ +++ YTF+K
Sbjct: 6 ILVTGSAGFIGFHLSKYLMDNYEDLKVIGIDNLNNYYNPV-LKEKRNEILKNYENYTFIK 64
Query: 58 GDVADFELVRELIK--KVDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKENP 115
D +D++ + E +K ++D IVH A++ V S+ +P ++ SN +GT + E R+ +
Sbjct: 65 LDFSDWDDLVENLKDKEIDLIVHLGAQAGVRYSLQNPWAYIKSNEMGTLNIFEFARRFDI 124
Query: 116 GVRLVHISTDEVYGDILKGSFTEEDRL-MPSSPYSATKAASDMLVLGWARTYGLNASITR 174
++V+ S+ VYG K F+E+DR+ P S Y++TK +++++ + YG+ R
Sbjct: 125 E-KVVYASSSSVYGGNRKIPFSEDDRVDKPISLYASTKRSNELMAHVYHHLYGIKMIGLR 183
Query: 175 CTNNYGPYQFPEKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRAIEAVLLKGEAR 234
YG Y P+ K +G ++ +Y G RD+ Y+ D V I + K
Sbjct: 184 FFTVYGEYGRPDMAYFKFAKNILLGKEIEVYNYGNMERDFTYISDVVDGILRAIKKDFDY 243
Query: 235 EIYNISAGEERTNLEVVRTILRIMDKDESLIEFVEDRPGHDIRYSLDSWKIIRELKWRPK 294
EI+N+ + + + I + ++K ++ +F+ + G +R D K + L ++PK
Sbjct: 244 EIFNLGNSKPVKLMYFIELIEKYLNK-KAKKKFLPMQDGDVLRTYADLSKSEKLLGYKPK 302
Query: 295 YRFEEGIKKTVEWYLENEWW 314
EEG+K+ W+LEN+ W
Sbjct: 303 VTIEEGLKRFCNWFLENKDW 322
>sp|P35675|YGAE_ERWAM HYPOTHETICAL PROTEIN IN GALE 3'REGION >gi|1073272|pir||B36951
hypothetical protein (galE 3' region) - Erwinia
amylovora (fragment) >gi|429079|emb|CAA53768.1|
(X76172) unidentified ORF [Erwinia amylovora]
Length = 164
Score = 144 bits (359), Expect = 2e-33
Identities = 81/165 (49%), Positives = 106/165 (64%), Gaps = 13/165 (7%)
Query: 1 MRILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDV 60
M+ILVTGG GFIGS IR+I+ +D V+N+DKLTY N +L++I D+PR F K D+
Sbjct: 1 MKILVTGGAGFIGSAVIRHIINNTDD-TVLNIDKLTYAGNLESLQEISDNPRDHFSKTDI 59
Query: 61 ADFELVRELIK--KVDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIR------- 111
D E ++ + D ++H AAESHVDRSI P F+ +N+IGTY LLEA R
Sbjct: 60 CDSESLKRAFNDFEPDVVMHLAAESHVDRSIDGPAAFIETNMIGTYVLLEAARMYWLGLP 119
Query: 112 -KENPGVRLVHISTDEVYGDI--LKGSFTEEDRLMPSSPYSATKA 153
+ RL HISTDEV+GD+ + FTE+ PSSPYSA+KA
Sbjct: 120 VERKEAFRLHHISTDEVFGDLHGTEDLFTEQTAYAPSSPYSASKA 164
>gb|AAB84886.1| (AE000823) UDP-glucose 4-epimerase homolog [Methanobacterium
thermoautotrophicum]
Length = 316
Score = 139 bits (348), Expect = 3e-32
Identities = 107/315 (33%), Positives = 160/315 (49%), Gaps = 16/315 (5%)
Query: 1 MRILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDV 60
M + VTGG+GFIGS+ +LE+ N VI D L+ GS P NL+D + ++G +
Sbjct: 4 MDVAVTGGLGFIGSHLTDELLERGNRVTVI--DDLSTGS-PDNLRDPHHED-LEIIEGSI 59
Query: 61 ADFELVRELIKKVDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKENPGVR-L 119
D +L ++ + D + H AA + V S+ P N GT +L A GVR +
Sbjct: 60 NDLDL-EKVFQGKDYVFHQAALASVPESVRDPLRCHRVNATGTLRVLMA--SSRAGVRKV 116
Query: 120 VHISTDEVYGDILKGSFTEEDRLMPSSPYSATKAASDMLVLGWARTYGLNASITRCTNNY 179
V+ ST VYG+ + E+ R MP SPY+ +K + + GL R N Y
Sbjct: 117 VNASTSAVYGNNPEIPLREDARPMPLSPYAVSKVTGEYYCQVF-EDQGLETVSLRYFNVY 175
Query: 180 GPYQFPEK----LIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRAIEAVLLKGEARE 235
GP Q P+ +IP+ I G IYG G+ RD++YV D VRA L +
Sbjct: 176 GPRQRPDSQYAAVIPRFIDALLSGRSPEIYGDGEQSRDFIYVGDVVRA-NIFLAESRGSG 234
Query: 236 IYNISAGEERTNLEVVRTILRIMDKDESLIEFVEDRPGHDIRYSLDSWKIIRELKWRPKY 295
+YN++ G T + I I++ D E++++RPG D+R+SL + +RP+
Sbjct: 235 VYNVAGGSSVTVNRLFDIISGILESDAEP-EYLDERPG-DVRHSLADTSRLAAAGFRPEV 292
Query: 296 RFEEGIKKTVEWYLE 310
EEG+ +TVEW+LE
Sbjct: 293 GLEEGLMRTVEWFLE 307
>pir||C69149 conserved hypothetical protein MTH380 - Methanobacterium
thermoautotrophicum (strain Delta H)
Length = 341
Score = 139 bits (348), Expect = 3e-32
Identities = 107/315 (33%), Positives = 160/315 (49%), Gaps = 16/315 (5%)
Query: 1 MRILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDV 60
M + VTGG+GFIGS+ +LE+ N VI D L+ GS P NL+D + ++G +
Sbjct: 29 MDVAVTGGLGFIGSHLTDELLERGNRVTVI--DDLSTGS-PDNLRDPHHED-LEIIEGSI 84
Query: 61 ADFELVRELIKKVDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKENPGVR-L 119
D +L ++ + D + H AA + V S+ P N GT +L A GVR +
Sbjct: 85 NDLDL-EKVFQGKDYVFHQAALASVPESVRDPLRCHRVNATGTLRVLMA--SSRAGVRKV 141
Query: 120 VHISTDEVYGDILKGSFTEEDRLMPSSPYSATKAASDMLVLGWARTYGLNASITRCTNNY 179
V+ ST VYG+ + E+ R MP SPY+ +K + + GL R N Y
Sbjct: 142 VNASTSAVYGNNPEIPLREDARPMPLSPYAVSKVTGEYYCQVF-EDQGLETVSLRYFNVY 200
Query: 180 GPYQFPEK----LIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRAIEAVLLKGEARE 235
GP Q P+ +IP+ I G IYG G+ RD++YV D VRA L +
Sbjct: 201 GPRQRPDSQYAAVIPRFIDALLSGRSPEIYGDGEQSRDFIYVGDVVRA-NIFLAESRGSG 259
Query: 236 IYNISAGEERTNLEVVRTILRIMDKDESLIEFVEDRPGHDIRYSLDSWKIIRELKWRPKY 295
+YN++ G T + I I++ D E++++RPG D+R+SL + +RP+
Sbjct: 260 VYNVAGGSSVTVNRLFDIISGILESDAEP-EYLDERPG-DVRHSLADTSRLAAAGFRPEV 317
Query: 296 RFEEGIKKTVEWYLE 310
EEG+ +TVEW+LE
Sbjct: 318 GLEEGLMRTVEWFLE 332
>gb|AAK41108.1| UDP-glucose 4-epimerase (galE-2) [Sulfolobus solfataricus]
Length = 310
Score = 138 bits (345), Expect = 7e-32
Identities = 100/318 (31%), Positives = 160/318 (49%), Gaps = 25/318 (7%)
Query: 1 MRILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDV 60
M+IL++GG GF+GS+ +LEK E+ +D L+ KD++ F+K V
Sbjct: 3 MKILISGGAGFLGSHLTEALLEKGE--EITIVDDLSTAKYFNIRKDVE------FIKKKV 54
Query: 61 ADFELVRELIKKVDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKENPGVRLV 120
+FE KK D ++H AA + I P + SN +GTY +LE RK N R +
Sbjct: 55 EEFETE----KKYDVVIHLAARPSPEDYIEHPVDTALSNSLGTYKMLEIARKSN--ARFI 108
Query: 121 HISTDEVYGD--ILKGSFTEEDRLMP---SSPYSATKAASDMLVLGWARTYGLNASITRC 175
+ S+ EVYG I+ T + P S Y +K S+ L++ + R Y L+ I R
Sbjct: 109 YTSSSEVYGSASIIPTPETYWGYVNPIGIRSCYDESKRFSEALIMAYHRQYKLDTRIQRP 168
Query: 176 TNNYGPYQFPE----KLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRA-IEAVLLK 230
N YGP + +++ + I +A G V ++G G R +LY+ D V A I+ +
Sbjct: 169 FNVYGPGLREDGTYGRVVSRFIYQALKGEDVTVFGDGNQTRAFLYISDWVDATIKLIYKD 228
Query: 231 GEAREIYNISAGEERTNLEVVRTILRIMDKDESLIEFVEDRPGHDIRYSLDSWKIIRELK 290
G E++NI + +E +E+ I+++ +S I+++ RP R + D K +L
Sbjct: 229 GLEGEVFNIGSDKEIKIIELANMIIKLTGS-KSRIKYLPPRPDDPPRRAADITKAKEKLG 287
Query: 291 WRPKYRFEEGIKKTVEWY 308
W PK EEG+K T+ W+
Sbjct: 288 WYPKISLEEGLKLTINWF 305
>emb|CAB57495.1| (Y18930) dTDP-glucose 4,6-dehydratase [Sulfolobus solfataricus]
Length = 310
Score = 138 bits (345), Expect = 7e-32
Identities = 100/318 (31%), Positives = 160/318 (49%), Gaps = 25/318 (7%)
Query: 1 MRILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDV 60
M+IL++GG GF+GS+ +LEK E+ +D L+ KD++ F+K V
Sbjct: 3 MKILISGGAGFLGSHLTEALLEKGE--EITIVDDLSTAKYFNIRKDVE------FIKKKV 54
Query: 61 ADFELVRELIKKVDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKENPGVRLV 120
+FE KK D ++H AA + I P + SN +GTY +LE RK N R +
Sbjct: 55 EEFETE----KKYDVVIHLAARPSPEDYIEHPVDTALSNSLGTYKMLEIARKSN--ARFI 108
Query: 121 HISTDEVYGD--ILKGSFTEEDRLMP---SSPYSATKAASDMLVLGWARTYGLNASITRC 175
+ S+ EVYG I+ T + P S Y +K S+ L++ + R Y L+ I R
Sbjct: 109 YTSSSEVYGSASIIPTPETYWGYVNPIGIRSCYDESKRFSEALIMAYHRQYKLDTRIQRP 168
Query: 176 TNNYGPYQFPE----KLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRA-IEAVLLK 230
N YGP + +++ + I +A G V ++G G R +LY+ D V A I+ +
Sbjct: 169 FNVYGPGLREDGTYGRVVSRFIYQALKGEDVTVFGDGNQTRAFLYISDWVDATIKLIYKD 228
Query: 231 GEAREIYNISAGEERTNLEVVRTILRIMDKDESLIEFVEDRPGHDIRYSLDSWKIIRELK 290
G E++NI + +E +E+ I+++ +S I+++ RP R + D K +L
Sbjct: 229 GLEGEVFNIGSDKEIKIIELANMIIKLTGS-KSRIKYLPPRPDDPPRRAADITKAKEKLG 287
Query: 291 WRPKYRFEEGIKKTVEWY 308
W PK EEG+K T+ W+
Sbjct: 288 WYPKISLEEGLKLTINWF 305
>gb|AAB48319.1| (U29691) CDP-tyvelose epimerase [Yersinia pseudotuberculosis]
Length = 338
Score = 134 bits (335), Expect = 1e-30
Identities = 106/339 (31%), Positives = 160/339 (46%), Gaps = 37/339 (10%)
Query: 1 MRILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDV 60
M++L+TGG GF+GSN + ++ + EVI D L+ + NLK +Q +T+V GD+
Sbjct: 1 MKLLITGGCGFLGSNLASHAIK--SGMEVIVFDNLSRYGSSDNLKWLQSIGGFTYVHGDI 58
Query: 61 ADFELVRELIKKV--DAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKENPGVR 118
+ + LI+K D+I H A + + SI +P NV GT+ LLEAIR NP
Sbjct: 59 RNRNDITRLIQKFKPDSIFHLAGQVAMTTSIDNPQMDFEVNVGGTFNLLEAIRLFNPECG 118
Query: 119 LVHISTDEVYGDI----------------LKGSFTEEDRLMPSSPYSATKAASDMLVLGW 162
+++ ST++VYGD+ + F E +L SPY +K A+D +L +
Sbjct: 119 IIYSSTNKVYGDLEQFTYRETDTRYECIEMPDGFDESTQLTFHSPYGCSKGAADQYMLDY 178
Query: 163 ARTYGLNASITRCTNNYGPYQFPE------KLIPKTIIRAKMGLKVP--IYGTGKNVRDW 214
AR YGL + R ++ YG QF + I A G+ P I G GK VRD
Sbjct: 179 ARIYGLKTVVFRHSSMYGGRQFSTYDQGWVGWFCQKAIEASRGVNSPFAISGNGKQVRDV 238
Query: 215 LYVEDHVRAIEAVL-----LKGEAREIYNISAG-EERTNLEVVRTILRIMDKDESLIEFV 268
L+ ED + + L +KG A +NI E +L + ++L + E +
Sbjct: 239 LHAEDIISLYFSTLSNLERVKGNA---FNIGGTIEHSLSLLELFSLLEKYTETELKYTRI 295
Query: 269 EDRPGHDIRYSLDSWKIIRELKWRPKYRFEEGIKKTVEW 307
R + + KI W PK E GIK ++W
Sbjct: 296 PVRESDQKVFVANINKISESTGWIPKVSSESGIKIMLDW 334
>dbj|BAB07368.1| (AP001519) UDP-glucose 4-epimerase [Bacillus halodurans]
Length = 311
Score = 134 bits (335), Expect = 1e-30
Identities = 106/322 (32%), Positives = 166/322 (50%), Gaps = 24/322 (7%)
Query: 2 RILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDVA 61
++LVTGG GFIGS+ + ++ + EV+ +D L+ GS LK + P K D+
Sbjct: 3 KVLVTGGAGFIGSHLVDLLIAEGT--EVVIVDNLSSGS----LKHVH--PSSHLFKLDIL 54
Query: 62 DFELVRELIKK---VDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKENPGVR 118
D E V ++ ++ +D IVH AA+S V S+ +P N+ GT LLE RK GV+
Sbjct: 55 D-ERVADVFQEHPDIDRIVHLAAQSKVGPSVLNPTYDAQVNIQGTIRLLEFSRKY--GVK 111
Query: 119 -LVHISTDEVYGDILKGSFTEEDRLMPSSPYSATKAASDMLVLGWARTYGLNASITRCTN 177
V S+ +YG EE +P SPY +K A++ V + R YGLN + R N
Sbjct: 112 QFVFASSAAIYGPSHTLPIREEFPALPLSPYGTSKYAAEAYVKTYGRLYGLNVHVLRFAN 171
Query: 178 NYGPYQFPEK---LIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRAIEAVL---LKG 231
YGP Q E +I I + + I+G GK RD+++V D V AI + L
Sbjct: 172 VYGPRQTAETEAGVISIFIEKLLKNEQPIIFGDGKQTRDFIFVLDVVNAIRSCLETETNQ 231
Query: 232 EAREIYNISAGEERTNLEVVRTILRIMDKDESLIEFVEDRPGHDIRYS-LDSWKIIRELK 290
E +YN+S G + + ++++ + ++ + F ++R G DI++S LD K+ + L
Sbjct: 232 EVDPVYNVSTGLQTSVEDLLKELCAQLNVTYA-PAFEQERSG-DIKHSCLDQQKLQKHLT 289
Query: 291 WRPKYRFEEGIKKTVEWYLENE 312
W P+ EG+ KT+ +Y E
Sbjct: 290 WNPRIALNEGLAKTIAYYQTRE 311
>pir||C72368 hypothetical protein TM0509 - Thermotoga maritima (strain MSB8)
>gi|4981021|gb|AAD35594.1|AE001727_6 (AE001727)
UDP-glucose 4-epimerase, putative [Thermotoga maritima]
Length = 309
Score = 134 bits (333), Expect = 2e-30
Identities = 103/315 (32%), Positives = 163/315 (51%), Gaps = 18/315 (5%)
Query: 1 MRILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDV 60
M ILVTGG GFIGS+ + ++E N + VI +D L+ G NL + F + +
Sbjct: 1 MNILVTGGAGFIGSHVVDKLIE--NGYGVIVVDNLSSGK-VENL-----NRNALFYEQSI 52
Query: 61 ADFELVREL--IKKVDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKENPGVR 118
D E++ + + + + + H AA++ V S+ P +N+IG+ LLE K
Sbjct: 53 EDEEMMERIFSLHRPEYVFHLAAQASVAISVREPARDAKTNIIGSLVLLEKSIKYGVKKF 112
Query: 119 LVHISTDEVYGDILKGSFTEEDRLM-PSSPYSATKAASDMLVLGWARTYGLNASITRCTN 177
+ + +YG+ +K T E + P SPY K +++M + +AR YGL ++ R N
Sbjct: 113 IFSSTGGAIYGENVKVFPTPETEIPHPISPYGIAKYSTEMYLEFFAREYGLKYTVLRYAN 172
Query: 178 NYGPYQFP---EKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRAIEAVLLKGEAR 234
YGP Q P ++ R G +V I+G G+ VRD++YV+D VRA + KG+
Sbjct: 173 VYGPRQDPYGEAGVVAIFTERMLRGEEVHIFGDGEYVRDYVYVDDVVRANLLAMEKGD-N 231
Query: 235 EIYNISAGEERTNLEVVRTILRIMDKDESLIEFVEDRPGHDIRYS-LDSWKIIRELKWRP 293
E++NI G T ++ + + I D+ + + R G D+R S LD K +L W P
Sbjct: 232 EVFNIGTGRGTTVNQLFKLLKEITGYDKEPV-YKPPRKG-DVRKSILDYTKAKEKLGWEP 289
Query: 294 KYRFEEGIKKTVEWY 308
K EEG+K TVE++
Sbjct: 290 KVSLEEGLKLTVEYF 304
>pir||T35486 probable nucleotide-sugar dehydratase - Streptomyces coelicolor
>gi|4008544|emb|CAA22513.1| (AL034492) putative
nucleotide-sugar dehydratase [Streptomyces coelicolor
A3(2)]
Length = 330
Score = 132 bits (330), Expect = 4e-30
Identities = 99/314 (31%), Positives = 149/314 (46%), Gaps = 14/314 (4%)
Query: 2 RILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDVA 61
R LVTGG GF+GS+ +L+ EV+ LD L GS AN+ D++ + FV+GD
Sbjct: 18 RALVTGGAGFVGSHLCGRLLDAGT--EVVCLDNLATGSR-ANVADLERRRGFRFVRGDAT 74
Query: 62 DFELVRELIKKVDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKENPGVRLVH 121
D +R L + D ++HFA + + P L GT LE R G R +
Sbjct: 75 DPAALRGLPGRFDLVLHFACPASPADYLRLPLETLDVGSTGTRNALE--RAHADGARFLL 132
Query: 122 ISTDEVYGDILKGSFTEE-----DRLMPSSPYSATKAASDMLVLGWARTYGLNASITRCT 176
ST EVYGD L+ E + + P S Y +K ++ LV + +G + +I R
Sbjct: 133 ASTSEVYGDPLEHPQRETYWGNVNPIGPRSVYDESKRFAEALVTAHRQVHGTDTAIVRIF 192
Query: 177 NNYGPYQ--FPEKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRAIEAVLLKGEAR 234
N YGP + +P I +A G+ + + G G R YV+D V + A+ GE+
Sbjct: 193 NTYGPRMRTGDGRAVPTFIAQALDGMPLTVAGDGGQTRSLCYVDDTVAGVLALAASGESG 252
Query: 235 EIYNISAGEERTNLEVVRTILRIMDKDESLIEFVEDRPGHDIRYSLDSWKIIRELKWRPK 294
+ NI +E T LE+ R ++ + S I FVE R D+ L WRP
Sbjct: 253 PM-NIGGDDEITMLELARRVVGLTGSG-SRIRFVERPVDDPCRRRPDTTLARERLGWRPG 310
Query: 295 YRFEEGIKKTVEWY 308
+ EG+++T+ W+
Sbjct: 311 VSWNEGLERTIGWF 324
>pir||G70415 nucleotide sugar epimerase - Aquifex aeolicus
>gi|2983750|gb|AAC07310.1| (AE000735) nucleotide sugar
epimerase [Aquifex aeolicus]
Length = 321
Score = 130 bits (323), Expect = 3e-29
Identities = 106/329 (32%), Positives = 162/329 (49%), Gaps = 21/329 (6%)
Query: 1 MRILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPA----NLKDIQDDPRYTFV 56
M ILVTG G IG +LE + VI +D L +P L+ ++ + F
Sbjct: 1 MNILVTGCAGLIGWKVSEKLLEHGH--RVIGVDNLNSYYDPRLKEYRLEQLKKFENFKFY 58
Query: 57 KGDVADFELVRELIKKV--DAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKEN 114
K ++ + E +R L ++ DA+++ AA + V SI +P + +N +G LLE + KE
Sbjct: 59 KVNIENREALRILFQEFEFDAVINEAARAGVRYSIQNPHIYFTTNTLGNLNLLE-LMKEF 117
Query: 115 PGVRLVHISTDEVYGDILKGSFTEEDRLMPSSPYSATKAASDMLVLGWARTYGLNASITR 174
+L+ ST +Y E P SPY+A+K A+++ + YG++ I R
Sbjct: 118 GVKKLILASTSSLYAGQPMPFKEELPVNTPISPYAASKKAAEVTAYTYHYLYGIDVVILR 177
Query: 175 CTNNYGPYQFPEKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRA-IEAVLLKGEA 233
YG P+ + I + G+ + +YG G RD+ YV+D A ++A+ LKG
Sbjct: 178 YFTVYGLAGRPDMAVFNFIYKTLKGIPIKVYGDGSQKRDFTYVDDVAEATVKALNLKG-- 235
Query: 234 REIYNISAGEERTNLEVVRTILRIMDKDESLIEFVEDRPGHDIRYSLDSW----KIIREL 289
EI N+ + R E++ I + K E +E+ D D+R D+W K R L
Sbjct: 236 YEIINVGNNKPRALKELIELIEKYTGK-EVKVEY-GDFHKADMR---DTWADITKAKRLL 290
Query: 290 KWRPKYRFEEGIKKTVEWYLENEWWWKPL 318
W PK EEG+KKTVEW+LEN W K L
Sbjct: 291 GWEPKTSLEEGVKKTVEWFLENWDWVKDL 319
>gb|AAD52168.1|AF144879_7 (AF144879) unknown [Leptospira interrogans]
Length = 332
Score = 129 bits (322), Expect = 4e-29
Identities = 106/324 (32%), Positives = 152/324 (46%), Gaps = 19/324 (5%)
Query: 2 RILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTF--VKGD 59
+ILVTG GFIGS+ ++ + +EV + L DD R F GD
Sbjct: 3 KILVTGADGFIGSHLTEALVR--SGFEVKAFVYYNSFNTWGWLDYCSDDVRGKFEIFTGD 60
Query: 60 VADFELVRELIKKVDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKENPGVRL 119
V D VR +K DA++H AA + S SPD ++ +N+ GT +L+A R N ++
Sbjct: 61 VRDPNGVRTAMKGTDAVLHLAALIGIPYSYHSPDTYIDTNIKGTLNVLQAARDLNLS-KV 119
Query: 120 VHISTDEVYGDILKGSFTEEDRLMPSSPYSATKAASDMLVLGWARTYGLNASITRCTNNY 179
+H ST EVYG TEE L SPYSA+K +D L + ++ I R N Y
Sbjct: 120 IHTSTSEVYGTAQFVPITEEHPLKGQSPYSASKIGADQLAYSFYSSFSTPVIIVRPFNTY 179
Query: 180 GPYQFPEKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRA-IEAVLLKGEAREIYN 238
GP Q +IP I + G G+ RD+ +V D V I A+ K E+ N
Sbjct: 180 GPRQSARAIIPTVITQLLSGKTKVQLGSTSPTRDFNFVTDTVNGFISALKSKQGFGEVIN 239
Query: 239 ISAGEERTNLEVVRTILRIMDKDESLIEFVED----RP--GHDIRYSLDSWKIIRELKWR 292
I G E + + V+ I I+ K+ IE V D RP R + K L W+
Sbjct: 240 IGNGFEISVGDTVKLIANIIGKE---IEIVSDSNRIRPEKSEVERLWASNQKAKDLLNWQ 296
Query: 293 PKYR----FEEGIKKTVEWYLENE 312
P Y F +G+++T+EW+ + E
Sbjct: 297 PAYNGLQGFRKGLEETIEWFKKPE 320
>gb|AAD12951.1| (AF078135) unknown [Leptospira borgpetersenii]
Length = 332
Score = 128 bits (319), Expect = 8e-29
Identities = 101/319 (31%), Positives = 152/319 (46%), Gaps = 17/319 (5%)
Query: 2 RILVTGGMGFIGSNFIRYILEKHNDWE--VINLDKLTYGSNPANLKDIQDDPRYTFVKGD 59
+ILVTG GFIGS+ ++ + + V T+G D++ ++ GD
Sbjct: 3 KILVTGADGFIGSHLTEALVRLGFEVKAFVYYNSFNTWGWLDYCSSDVRG--KFEIFTGD 60
Query: 60 VADFELVRELIKKVDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKENPGVRL 119
V D VR +K +DA++H AA + S SPD ++ +N+ GT +L+A R N R+
Sbjct: 61 VRDPNGVRTAMKGIDAVLHLAALIGIPYSYHSPDTYVDTNIKGTLNVLQAARDLNLS-RV 119
Query: 120 VHISTDEVYGDILKGSFTEEDRLMPSSPYSATKAASDMLVLGWARTYGLNASITRCTNNY 179
+H ST EVYG TEE L SPYSA+K +D L + ++ I R N Y
Sbjct: 120 IHTSTSEVYGTAQFVPITEEHPLKGQSPYSASKIGADQLAYSFYSSFSTPVIIVRPFNTY 179
Query: 180 GPYQFPEKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRA-IEAVLLKGEAREIYN 238
GP Q +IP I + G G+ RD+ +V D V I A+ K E+ N
Sbjct: 180 GPRQSARAIIPTVITQLLSGKTKIQLGSTSPTRDFNFVTDTVNGFISALKSKQGLGEVIN 239
Query: 239 ISAGEERTNLEVVRTILRIMDKDESLIEFVED-RPGHDIRYSLDSWKIIRELK----WRP 293
I G E + + V+ I I+DK+ ++ V RP L W ++ K W+P
Sbjct: 240 IGNGFEISVGDTVKLIASILDKEVEIVSDVNRIRPEKSEVERL--WSSNQKAKDLFGWQP 297
Query: 294 KYR----FEEGIKKTVEWY 308
Y F+ G+ +T+EW+
Sbjct: 298 AYSGLEGFKRGLTETIEWF 316
>pir||H71145 probable UDP-glucose 4-epimerase - Pyrococcus horikoshii
>gi|3256770|dbj|BAA29453.1| (AP000002) 318aa long
hypothetical UDP-glucose 4-epimerase [Pyrococcus
horikoshii]
Length = 318
Score = 128 bits (319), Expect = 8e-29
Identities = 108/329 (32%), Positives = 163/329 (48%), Gaps = 33/329 (10%)
Query: 1 MRILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDV 60
MR+LVTGG GFIGS+ + ++E+ ++V LD L+ GS N++ + + F+KGD+
Sbjct: 1 MRVLVTGGAGFIGSHLVDRLMEE--GYKVRVLDDLSAGSLK-NIEGWLGNENFEFIKGDM 57
Query: 61 ADFELVRELIKKVDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKENPGVR-L 119
D E+V + +K VDA+ H AA V SP+ +NV+ TY LL A+R N GV+ L
Sbjct: 58 RDVEIVSKAVKDVDAVFHLAANPEVRIGSQSPELLYETNVLITYNLLNAVR--NSGVKYL 115
Query: 120 VHISTDEVYGDILKGSFTEED--RLMPSSPYSATKAASDMLVLGWARTYGLNASITRCTN 177
V S+ VYGD K T ED L P S Y A K A++ L+ G+A T+ A I R N
Sbjct: 116 VFTSSSTVYGD-AKVIPTPEDYAPLEPISVYGAAKLAAEALISGYAHTFDFRALIIRLAN 174
Query: 178 NYGP-------YQFPEKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRAIEAV--- 227
G Y F KL +A ++ I G G + +L++ D + I +
Sbjct: 175 IIGKRSNHGVIYDFINKL------KANPN-ELEILGDGTQRKSYLHISDTIDGIMKLFEH 227
Query: 228 LLKGEAR-EIYNISAGEERTNLEVVRTILRIMDKDESLIEFVEDRPG-----HDIRYSLD 281
L GE R + YN+ + T E+ + M+ + +F G D++ L
Sbjct: 228 FLNGEERVDFYNLGNEDWITVKEIAEIVSEEMNLNPR-FKFTGGVDGGRGWKGDVKLMLL 286
Query: 282 SWKIIRELKWRPKYRFEEGIKKTVEWYLE 310
S + + W+P+ E ++KTV LE
Sbjct: 287 SIEKAKRTGWKPRMNSYEAVRKTVREMLE 315
>pir||C70562 probable DTDP-Glucose 4 - Mycobacterium tuberculosis (strain H37RV)
>gi|2105060|emb|CAB08849.1| (Z95436) rmlB2
[Mycobacterium tuberculosis]
Length = 314
Score = 126 bits (314), Expect = 3e-28
Identities = 101/316 (31%), Positives = 154/316 (47%), Gaps = 16/316 (5%)
Query: 1 MRILVTGGMGFIGSNFI-RYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGD 59
MR LVTG GFIGS + R + + H+ V+ LD G NL+ + D+ + FV+ D
Sbjct: 1 MRALVTGAAGFIGSTLVDRLLADGHS---VVGLDNFATG-RATNLEHLADNSAHVFVEAD 56
Query: 60 V--ADFELVRELIKKVDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKENPGV 117
+ AD + E + + + H AA+ V RS++ P NVIGT L EA R+ GV
Sbjct: 57 IVTADLHAILEQ-HRPEVVFHLAAQIDVRRSVADPQFDAAVNVIGTVRLAEAARQT--GV 113
Query: 118 R-LVHISTD-EVYGDILKGSFTEEDRLMPSSPYSATKAASDMLVLGWARTYGLNASITRC 175
R +VH S+ +YG + E P+SPY+A K A ++ + + YGL+ S
Sbjct: 114 RKIVHTSSGGSIYGTPPEYPTPETAPTDPASPYAAGKVAGEIYLNTFRHLYGLDCSHIAP 173
Query: 176 TNNYGPYQFPEKLIPKTIIRAK---MGLKVPIYGTGKNVRDWLYVEDHVRAIEAVLLKGE 232
N YGP Q P I A+ G ++G G N RD+++V+D V A V
Sbjct: 174 ANVYGPRQDPHGEAGVVAIFAQALLSGKPTRVFGDGTNTRDYVFVDDVVDAFVRVSADVG 233
Query: 233 AREIYNISAGEERTNLEVVRTILRIMDKDESLIEFVEDRPGHDIRYSLDSWKIIRELKWR 292
+NI G+E ++ ++ + + + EF R G R LD R L WR
Sbjct: 234 GGLRFNIGTGKETSDRQLHSAVAAAVGGPDD-PEFHPPRLGDLKRSCLDIGLAERVLGWR 292
Query: 293 PKYRFEEGIKKTVEWY 308
P+ +G+++TVE++
Sbjct: 293 PQIELADGVRRTVEYF 308
>dbj|BAB07098.1| (AP001518) UDP-glucose 4-epimerase [Bacillus halodurans]
Length = 308
Score = 125 bits (312), Expect = 5e-28
Identities = 94/311 (30%), Positives = 154/311 (49%), Gaps = 14/311 (4%)
Query: 2 RILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDVA 61
++LVTGG GFIGS+ + +L K +EV+ +D LT G N+ F K D+
Sbjct: 4 KVLVTGGAGFIGSHIVELLLNK--GYEVVVVDNLTTGQFE-NISSFN----VPFYKTDIV 56
Query: 62 DFELVRELIK-KVDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKENPGVRLV 120
EL K K + ++H AA+ V +SI+ P +N+IGT LL + +++
Sbjct: 57 SSELKDIFSKEKPNYVIHHAAQVDVTKSINLPTYDAETNIIGTINLLSCCCQYEVD-KVI 115
Query: 121 HISTDEVYGDILKGSFTEEDRLMPSSPYSATKAASDMLVLGWARTYGLNASITRCTNNYG 180
+ S+ VYGD S TE+ + P S Y +K+ +M + + YGL +I R N YG
Sbjct: 116 YASSCAVYGDTGDSSITEDFPIQPISFYGISKSVPEMYIRQFHDLYGLKYTIFRYANVYG 175
Query: 181 PYQFPE---KLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRAIEAVLLKGEAREIY 237
P Q + +I +A + IYG G+ RD++YVED +A L G+ EI+
Sbjct: 176 PRQTSKGEGGVISIFTTKALKREQPIIYGNGEQTRDFIYVEDIAKANALALDIGD-NEIF 234
Query: 238 NISAGEERTNLEVVRTILRIMDKDESLIEFVEDRPGHDIRYSLDSWKIIRELKWRPKYRF 297
NI ++T++ + + ++ ++ R G + L K + L W+P
Sbjct: 235 NIGT-NQKTSINELYNKVNVVRPFAPSAKYTSPREGDILHSRLSYVKAKKILGWKPSVSL 293
Query: 298 EEGIKKTVEWY 308
E GI++T+++Y
Sbjct: 294 ERGIQETLKYY 304
>pir||A75008 udp-glucose 4-epimerase (gale-2) PAB1299 - Pyrococcus abyssi
(strain Orsay) >gi|5459017|emb|CAB50503.1| (AJ248288)
UDP-glucose 4-epimerase (galE-2) [Pyrococcus abyssi]
Length = 317
Score = 125 bits (311), Expect = 7e-28
Identities = 98/322 (30%), Positives = 156/322 (48%), Gaps = 29/322 (9%)
Query: 1 MRILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDV 60
M++LVTGG GFIGS+ + ++E + +EV LD L+ GS NL ++ + F++GD+
Sbjct: 1 MKVLVTGGAGFIGSHLVDRLME--DGYEVRVLDDLSAGSLE-NLNRWLENENFEFIRGDM 57
Query: 61 ADFELVRELIKKVDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKENPGVRLV 120
D+++V+E + V+ + H AA V S SP+ +NV+ TY LL+AIR+ N LV
Sbjct: 58 RDYKIVKEAVDDVEVVFHLAANPEVRISSQSPELLYETNVLITYNLLQAIRESNVKF-LV 116
Query: 121 HISTDEVYGDILKGSFTEE-DRLMPSSPYSATKAASDMLVLGWARTYGLNASITRCTNNY 179
S+ VYGD E L P S Y K A++ L+ G+A +G A I R N
Sbjct: 117 FTSSSTVYGDANVLPTPESYGPLEPISVYGGAKLAAEALISGYAHIFGFRALIFRLANII 176
Query: 180 GP-------YQFPEKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRAI----EAVL 228
G Y F KL + ++ I G GK + +L+V D + I E
Sbjct: 177 GKRSNHGVIYDFINKL-------KRNPNELEILGDGKQRKSYLHVSDTINGILHIFEYFK 229
Query: 229 LKGEAREIYNISAGEERTNLEVVRTILRIMDKDESLIEFVEDRPG-----HDIRYSLDSW 283
+ + ++YN+ + T E+ + M +F G D+++ L S
Sbjct: 230 RQNKIFDVYNLGNEDWITVKEIAEIVSEEMGLSPK-FKFTGGVDGGRGWKGDVKFMLLSI 288
Query: 284 KIIRELKWRPKYRFEEGIKKTV 305
+ ++ WRPK E +++TV
Sbjct: 289 EKAKKTGWRPKMNSYEAVRRTV 310
>dbj|BAA25656.1| (AB005901) deduced dNDP-hexose 4,6-dehydratase [Streptomyces
kasugaensis]
Length = 329
Score = 123 bits (306), Expect = 3e-27
Identities = 90/313 (28%), Positives = 142/313 (44%), Gaps = 7/313 (2%)
Query: 2 RILVTGGMGFIGSNFIRYILEKHNDWEVI--NLDKLTYGSNPANLKDIQDDPRYTFVKGD 59
++LVTG GFIGS+ ++ + + + NL D V D
Sbjct: 12 QVLVTGADGFIGSHLTETLVSRGARVTAVVRRVSAAQVTHRLRNLSAATVDALERVVHVD 71
Query: 60 VADFELVRELIK-KVDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKENPGVR 118
+A V L + + D H AA+++V S+ P + + +NV+ T +L A ++ P
Sbjct: 72 LAGPSAVDVLGRLEADTWFHLAADAYVPASLDQPADVVRTNVMSTLHVLLAAQQRQPAHL 131
Query: 119 LVHISTDEVYGDILKGSFTEEDRLMPSSPYSATKAASDMLVLGWARTYGLNASITRCTNN 178
LV S+ EVYG + TE L P++PY+A+K A D L W TYGL +I R N+
Sbjct: 132 LV-TSSSEVYGS-QPDAITERHPLEPATPYAASKVACDRLAWSWHHTYGLPLTIVRPFNS 189
Query: 179 YGPYQFPEKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRAIEAVLLKGEAREIYN 238
YGP + +P + RA G + I G+G+ RD +V D V A+ E YN
Sbjct: 190 YGPRHVYD-AVPLFLARALRGEPITINGSGEQTRDLTFVADTVAGFLALAELPATGETYN 248
Query: 239 ISAGEERTNLEVVRTILRIMDKDESLIEFVEDRPGHDIRYSLDSWKIIRELKWRPKYRFE 298
I G + ++V R I+ + ++ R G ++ D K+ WR +Y
Sbjct: 249 IGTGTDHRIIDVARAIVALTGSQSEIVH-GPPRSGEVLKLQADPAKLTEATGWRAEYDLA 307
Query: 299 EGIKKTVEWYLEN 311
G+ + W E+
Sbjct: 308 RGLADNLVWMREH 320
>sp|P14169|RFBE_SALTI CDP-TYVELOSE-2-EPIMERASE >gi|861175|gb|AAB49384.1| (M29682)
CDP-tyvelose epimerase [Salmonella enterica]
Length = 338
Score = 121 bits (300), Expect = 1e-26
Identities = 97/349 (27%), Positives = 154/349 (43%), Gaps = 57/349 (16%)
Query: 1 MRILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDV 60
M++L+TGG GF+GSN + L + D +I D L+ NL + + FV GD+
Sbjct: 1 MKLLITGGCGFLGSNLASFALSQGID--LIVFDNLSRKGATDNLHWLSSLGNFEFVHGDI 58
Query: 61 ADFELVRELIKKV--DAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKENPGVR 118
+ V LI K D+ H A + + SI +P NV GT LLEA+R+ N
Sbjct: 59 RNKNDVTRLITKYMPDSCFHLAGQVAMTTSIDNPCMDFEINVGGTLNLLEAVRQYNSNCN 118
Query: 119 LVHISTDEVYGDILK----------------GSFTEEDRLMPSSPYSATKAASDMLVLGW 162
+++ ST++VYGD+ + + E +L SPY +K A+D +L +
Sbjct: 119 IIYSSTNKVYGDLEQYKYNETETRYTCVDKPNGYDESTQLDFHSPYGCSKGAADQYMLDY 178
Query: 163 ARTYGLNASITRCTNNYGPYQFPE------KLIPKTIIRAKMGLKVP--IYGTGKNVRDW 214
AR +GLN + R ++ YG QF + + K G+ P I G GK VRD
Sbjct: 179 ARIFGLNTVVFRHSSMYGGRQFATYDQGWVGWFCQKAVEIKNGINKPFTISGNGKQVRDV 238
Query: 215 LYVEDHVRAIEAVL-----LKGEAREIYNISAG-----------EERTNLEVVRTILRIM 258
L+ ED + L ++G A I E+ N+++ T L +
Sbjct: 239 LHAEDMISLYFTALANVSKIRGNAFNIGGTIVNSLSLLELFKLLEDYCNIDMRFTNLPVR 298
Query: 259 DKDESLIEFVEDRPGHDIRYSLDSWKIIRELKWRPKYRFEEGIKKTVEW 307
+ D+ + + D KI + W PK ++G++K +W
Sbjct: 299 ESDQRV-------------FVADIKKITNAIDWSPKVSAKDGVQKMYDW 334
>dbj|BAB06023.1| (AP001515) nucleotide sugar epimerase (capsular polysaccharide
biosynthesis) [Bacillus halodurans]
Length = 315
Score = 118 bits (293), Expect = 9e-26
Identities = 93/315 (29%), Positives = 147/315 (46%), Gaps = 10/315 (3%)
Query: 1 MRILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGS----NPANLKDIQDDPRYTFV 56
MRILVTG GFIGS+ +L + V+ +D S N++++ PR+T +
Sbjct: 1 MRILVTGAAGFIGSHLCEQLL-MNEKVSVVGVDGHIDSSLCKVKERNVRNLLKHPRFTLL 59
Query: 57 KGDVADFELVRELIKKVDAIVHFAAESHVDRSISSP-DNFLHSNVIGTYTLLEAIRKENP 115
K D+ +L L+ +VD I H + V S + ++ N++ T LLEA R+ +
Sbjct: 60 KQDLLTIDL-EPLVDQVDVIYHLSGIPGVRSSWGTDFKKYVTHNIVATQQLLEACRRHSL 118
Query: 116 GVRLVHISTDEVYGDILKGSFTEEDRLMPSSPYSATKAASDMLVLGWARTYGLNASITRC 175
+ ++IST VYG G E+ P SPY +K + L + R + + I R
Sbjct: 119 E-KFIYISTSSVYGQ-KNGKVGEKASPTPLSPYGVSKLTGEHLCNVYYRNFSIPTVILRY 176
Query: 176 TNNYGPYQFPEKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRAIEAVLLKGEARE 235
YGP Q + + I +PI+G G RD+ Y++D + A AVL E
Sbjct: 177 FTVYGPRQRQDMAFHRFIKAIIDNQPIPIFGDGNQSRDFTYIDDCIAATCAVLHADVIGE 236
Query: 236 IYNISAGEERTNLEVVRTILRIMDKDESLIEFVEDRPGHDIRYSLDSWKIIRELKWRPKY 295
NI E T L+++ + I KD L +F+E G + D K + L++ P
Sbjct: 237 TINIGGKERATVLQIISMLESIFQKDAKL-QFLEKPFGEPMSTWADISKAEKLLRYSPNV 295
Query: 296 RFEEGIKKTVEWYLE 310
+GI+K V+ L+
Sbjct: 296 PLLQGIEKEVDDLLD 310
>sp|Q04973|VIPB_SALTI VI POLYSACCHARIDE BIOSYNTHESIS PROTEIN VIPB/TVIC
>gi|1361288|pir||C36892 Vi polysaccharide biosynthetic
protein vipB - Salmonella typhi
>gi|47961|emb|CAA47992.1| (X67785) wcdB; ORF3 in
citation [1] [Salmonella typhi]
>gi|426446|dbj|BAA03193.1| (D14156) WcdB protein
[Salmonella typhi]
Length = 348
Score = 116 bits (288), Expect = 4e-25
Identities = 97/331 (29%), Positives = 160/331 (48%), Gaps = 30/331 (9%)
Query: 2 RILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDD------PRYTF 55
R L+TG GFIGS + +L + VI LD + G NL D++ R+ F
Sbjct: 17 RWLITGVAGFIGSGLLEELLFLNQT--VIGLDNFSTGYQH-NLDDVRTSVSEEQWSRFIF 73
Query: 56 VKGDVADFELVRELIKKVDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKENP 115
++GD+ F ++ K VD ++H AA V RS+ P +N+ G +L A R +
Sbjct: 74 IQGDIRKFTDCQKACKNVDYVLHQAALGSVPRSLKDPIATNSANIDGFLNMLTAARDAHV 133
Query: 116 GVRLVHISTDEVYGDILKGSFTEEDRLMPSSPYSATKAASDMLVLGWARTYGLNASITRC 175
+ ++ YGD EE P SPY+ TK +++ +AR+Y NA R
Sbjct: 134 S-SFTYAASSSTYGDHPDLPKIEERIGRPLSPYAVTKYVNELYADVFARSYEFNAIGLRY 192
Query: 176 TNNYGPYQFP----EKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRAIEAVLLKG 231
N +G Q P +IP+ I+ + I G G RD+ Y+E+ I+A LL
Sbjct: 193 FNVFGRRQNPNGAYSAVIPRWILSLLKDEPIYINGDGSTSRDFCYIEN---VIQANLLSA 249
Query: 232 EARE------IYNISAGEERTNLE----VVRTILRIMDKDESLIE-FVEDRPGHDIRYS- 279
+ +YN++ G +RT+L ++R L + ++S E +D D+++S
Sbjct: 250 TTNDLASKNKVYNVAVG-DRTSLNELYYLIRDGLNLWRNEQSRAEPIYKDFRDGDVKHSQ 308
Query: 280 LDSWKIIRELKWRPKYRFEEGIKKTVEWYLE 310
D KI L + P++ +EG+K+T++WY++
Sbjct: 309 ADITKIKTFLSYEPEFDIKEGLKQTLKWYID 339
>dbj|BAA19651.1| (AB002668) unnamed protein product [Actinobacillus
actinomycetemcomitans]
Length = 180
Score = 115 bits (284), Expect = 1e-24
Identities = 54/113 (47%), Positives = 80/113 (70%), Gaps = 3/113 (2%)
Query: 1 MRILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDV 60
M+ L+TGG GFIGS IR++++ H + ++IN+DKLTY N L ++ PRY F + D+
Sbjct: 1 MQFLITGGAGFIGSALIRWLIQ-HTEHDIINVDKLTYAGNLCALYSVETHPRYHFEQTDI 59
Query: 61 ADFELVRELIKKV--DAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIR 111
D +++ ++ + DA++H AAESHVDRSI +P F+ +N+IGTYTLLEA R
Sbjct: 60 CDGQMMAHILSQYRPDAVIHLAAESHVDRSIDAPAAFMQTNIIGTYTLLEAAR 112
>dbj|BAA82544.1| (AB030032) ORF18 [Actinobacillus actinomycetemcomitans]
Length = 180
Score = 115 bits (284), Expect = 1e-24
Identities = 54/113 (47%), Positives = 80/113 (70%), Gaps = 3/113 (2%)
Query: 1 MRILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDV 60
M+ L+TGG GFIGS IR++++ H + ++IN+DKLTY N L ++ PRY F + D+
Sbjct: 1 MQFLITGGAGFIGSALIRWLIQ-HTEHDIINVDKLTYAGNLCALYSVEPHPRYHFEQTDI 59
Query: 61 ADFELVRELIKKV--DAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIR 111
D +++ ++ + DA++H AAESHVDRSI +P F+ +N+IGTYTLLEA R
Sbjct: 60 CDGQMMAHILSQYRPDAVIHLAAESHVDRSIDAPAAFMQTNIIGTYTLLEAAR 112
>sp|Q9KDV3|GALE_BACHD UDP-GLUCOSE 4-EPIMERASE (GALACTOWALDENASE) (UDP-GALACTOSE
4-EPIMERASE) >gi|10173723|dbj|BAB04827.1| (AP001510)
UDP-glucose 4-epimerase [Bacillus halodurans]
Length = 334
Score = 114 bits (282), Expect = 2e-24
Identities = 99/337 (29%), Positives = 157/337 (46%), Gaps = 41/337 (12%)
Query: 1 MRILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDV 60
M ILVTGG G+IGS+ + ++LE+ +VI LD L G A L D+ TF GD+
Sbjct: 1 MAILVTGGAGYIGSHTVLFLLEQGE--QVIVLDNLQKGHAGA-LSDV------TFYHGDI 51
Query: 61 ADFELVRELIK--KVDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKENPGVR 118
D +L+ + +D ++HFAA S V S+ P + +NVIGT+TLL+ + E+ +
Sbjct: 52 RDDQLLDTIFTTHSIDTVIHFAANSLVGESVKQPIEYYENNVIGTHTLLKKM-LEHDVKK 110
Query: 119 LVHISTDEVYGDILKGSFTEEDRLMPSSPYSATKAASDMLVLGWARTYGL--------NA 170
+V ST YG+ ++ E D +P++PY TK A + + YGL NA
Sbjct: 111 IVFSSTAATYGEPVQIPIQESDPTIPTNPYGETKLAIEKMFHWCQEAYGLQYVCLRYFNA 170
Query: 171 SITRCTNNYGPYQFPEKLIPKTIIRAKMGL--KVPIYG------TGKNVRDWLYVED--- 219
+ G PE + +++ +G +V I+G G +RD+++V D
Sbjct: 171 AGADPNGRIGEDHSPESHLIPIVLQVALGQRERVAIFGDDYQTEDGSCIRDYIHVMDLAN 230
Query: 220 -HVRAIEAVLLKGEAREIYNISAGEERTNLEVVRTILRIMDKDESLIEFVEDRPGHDIRY 278
H A E + G++ +N+ G+ + EV+ + R + E R G
Sbjct: 231 AHYLACEHLRKDGQSGS-FNLGNGKGFSVKEVIE-VCRQVTGHPIPAEIAPRRSGDPASL 288
Query: 279 SLDSWKIIRELKWRPKYRFEEGIKKTVEWYLENEWWW 315
S K L W PKY ++E +E+ W W
Sbjct: 289 IASSEKAQTILGWEPKY-------PSLETMVEHAWNW 318
>gb|AAC79582.1| (AC005727) putative nucleotide-sugar dehydratase [Arabidopsis
thaliana]
Length = 343
Score = 113 bits (281), Expect = 2e-24
Identities = 93/308 (30%), Positives = 143/308 (46%), Gaps = 18/308 (5%)
Query: 1 MRILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDV 60
MRILVTGG GFIGS+ + +++ + EVI D GS NLK PR+ ++ DV
Sbjct: 31 MRILVTGGAGFIGSHLVDKLMQNEKN-EVIVADNYFTGSKD-NLKKWIGHPRFELIRHDV 88
Query: 61 ADFELVRELIKKVDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKENPGVRLV 120
+ L +VD I H A + +P + +NVIGT +L ++ G R++
Sbjct: 89 TE-----PLFVEVDQIYHLACPASPIFYKYNPVKTIKTNVIGTLNMLGLAKR--VGARIL 141
Query: 121 HISTDEVYGDILKGSFTEE-----DRLMPSSPYSATKAASDMLVLGWARTYGLNASITRC 175
ST EVYGD L TE + + S Y K ++ L+ + R +G+ I R
Sbjct: 142 LTSTSEVYGDPLVHPQTESYWGNVNPIGVRSCYDEGKRVAETLMFDYHRQHGIEIRIARI 201
Query: 176 TNNYGPYQFPE--KLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRAIEAVLLKGEA 233
N YGP + +++ I +A G + + G R + YV D V + L++G+
Sbjct: 202 FNTYGPRMNIDDGRVVSNFIAQALRGEALTVQKPGTQTRSFCYVSDMVEGLMR-LMEGDQ 260
Query: 234 REIYNISAGEERTNLEVVRTILRIMDKDESLIEFVEDRPGHDIRYSLDSWKIIRELKWRP 293
NI E T +E+ T+ ++ D I+ VE+ P + D K L W P
Sbjct: 261 TGPINIGNPGEFTMVELAETVKELIKPDVE-IKMVENTPDDPRQRKPDISKAKEVLGWEP 319
Query: 294 KYRFEEGI 301
K + EG+
Sbjct: 320 KVKLREGL 327
>pir||H69988 NDP-sugar epimerase homolog ytcB - Bacillus subtilis
>gi|2293288|gb|AAC00366.1| (AF008220) YtcB [Bacillus
subtilis] >gi|2635571|emb|CAB15065.1| (Z99119) similar
to NDP-sugar epimerase [Bacillus subtilis]
Length = 316
Score = 113 bits (279), Expect = 4e-24
Identities = 101/319 (31%), Positives = 150/319 (46%), Gaps = 23/319 (7%)
Query: 1 MRILVTGGMGFIGSNFIRYILE--KHNDWEVINLDKLTYGSNP-----ANLKDIQDDPRY 53
M+ILVTG GFIGS+ +L+ KHN VI +D G P NLK++ + R+
Sbjct: 1 MKILVTGAAGFIGSHLCEELLKDKKHN---VIGIDDFI-GPTPFSLKLKNLKNLLPEKRF 56
Query: 54 TFVKGDVADFELVRELIKKVDAIVHFAAESHVDRSISSPDNFLHS----NVIGTYTLLEA 109
TF+K ++ +L L++ VD I H AA V SS N H N+ LLEA
Sbjct: 57 TFIKENLLTADLA-SLLEGVDVIFHLAAIPGVR---SSWGNHFHPYAAHNIQALQRLLEA 112
Query: 110 IRKENPGVRLVHISTDEVYGDILKGSFTEEDRLMPSSPYSATKAASDMLVLGWARTYGLN 169
R E+ V ST VYG+ +G +E L P SPY TK + L + +++G+
Sbjct: 113 CR-EHSIQTFVFASTSSVYGE-KQGKVSENTSLSPLSPYGVTKLTGEKLCHVYKQSFGIP 170
Query: 170 ASITRCTNNYGPYQFPEKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRAIEAVLL 229
I R YGP Q P+ + I + + I+G G+ RD+ Y+ D V+ I AVL
Sbjct: 171 IVILRFFTVYGPRQRPDMAFHRLIKQHLQQKPLTIFGDGQQSRDFTYISDCVKGITAVLG 230
Query: 230 KGE-AREIYNISAGEERTNLEVVRTILRIMDKDESLIEFVEDRPGHDIRYSLDSWKIIRE 288
K E NI E + L+VV I I + ++ + F + G D K +
Sbjct: 231 KPHLIGETVNIGGAERASVLKVVSLIEDISGR-KATLHFSDKIAGEPSNTWADISKAKQL 289
Query: 289 LKWRPKYRFEEGIKKTVEW 307
L + P ++G+ + +
Sbjct: 290 LHYDPATSLKDGLTNEIAY 308
>pir||T00116 hypothetical protein 20 - Actinobacillus actinomycetemcomitans
>gi|3132268|dbj|BAA28145.1| (AB010415) ORF20
[Actinobacillus actinomycetemcomitans]
Length = 180
Score = 112 bits (278), Expect = 5e-24
Identities = 53/113 (46%), Positives = 79/113 (69%), Gaps = 3/113 (2%)
Query: 1 MRILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDV 60
M+ L+TGG GFIGS IR++++ H + ++IN+DKL Y N L ++ PRY F + D+
Sbjct: 1 MQFLITGGAGFIGSALIRWLIQ-HTEHDIINVDKLPYAGNLCALYSVETHPRYHFEQTDI 59
Query: 61 ADFELVRELIKKV--DAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIR 111
D +++ ++ + DA++H AAESHVDRSI +P F+ +N+IGTYTLLEA R
Sbjct: 60 CDGQMMAHILSQYRPDAVIHLAAESHVDRSIDAPAAFMQTNIIGTYTLLEAAR 112
>pir||C69148 dTDP-glucose 4,6-dehydratase related protein - Methanobacterium
thermoautotrophicum (strain Delta H)
>gi|2621434|gb|AAB84879.1| (AE000823) dTDP-glucose
4,6-dehydratase related protein [Methanobacterium
thermoautotrophicum]
Length = 334
Score = 112 bits (277), Expect = 7e-24
Identities = 97/331 (29%), Positives = 155/331 (46%), Gaps = 41/331 (12%)
Query: 2 RILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDVA 61
RILVTGG GFIG+N + + ++ EV+ +D + R +++ DV
Sbjct: 26 RILVTGGAGFIGTNLVNEL--RNRGHEVLAVD-------------LMHTEREDYMRADVR 70
Query: 62 DFELVRELIK--KVDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKENPGVRL 119
++ V + + K D + H AAE +N +NVIGT +L +E G R+
Sbjct: 71 EYRQVERIFEEDKFDYVYHLAAEYGRWNGEDYYENLWKTNVIGTKHMLRM--QEKLGFRM 128
Query: 120 VHISTDEVYGDILKGSFTEEDRLMPSSP---------YSATKAASDMLVLGWARTYGLNA 170
+ S+ EVYGD G +E+ +M +P Y+ TK A +++ + A +G
Sbjct: 129 IFFSSAEVYGDY-SGLMSED--VMVKNPISDTYQMNDYAITKWAGELMCMNSAEMFGTET 185
Query: 171 SITRCTNNYGPYQ--FPEK-LIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRAIEAV 227
R N YGP++ P K IP I A +Y K + D YVED VR +
Sbjct: 186 VRVRPVNCYGPHEKYSPYKGFIPIFIYHALHRKPYTVYKGHKRIID--YVEDSVRTFANI 243
Query: 228 LLKGEAREIYNISAGEERTN--LEVVRTILRIMDKDESLIEFVEDRPGHDIRYSLDSWKI 285
+ E+YN+ E + E +L + D+S++ + E P ++D K
Sbjct: 244 VDNFIPGEVYNVGGRTEWEHDIKEYSDMVLEAVGIDDSIVTYRESEPFTTKVKTMDFSKA 303
Query: 286 IRELKWRPKYRFEEGIKKTVEWYLENEWWWK 316
IR+LK P+ EEGI++TVEW +W+++
Sbjct: 304 IRDLKHDPQVPPEEGIRRTVEWM---KWYYR 331
>emb|CAA18814.1| (AL023093) putative sugar dehyratase [Mycobacterium leprae]
Length = 319
Score = 112 bits (277), Expect = 7e-24
Identities = 93/315 (29%), Positives = 152/315 (47%), Gaps = 14/315 (4%)
Query: 1 MRILVTGGMGFIGSNFI-RYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGD 59
+R LVTG GFIGS + R + + H V+ LD G + ANL+ + P FV+ D
Sbjct: 6 VRALVTGAAGFIGSTLVDRLLADGHT---VVGLDNFATG-HAANLEHLASTPALAFVEAD 61
Query: 60 VADFELVRELIK-KVDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKENPGVR 118
+ +L L + + + + H AA+ V S+ P NVIGT L EA R + GVR
Sbjct: 62 IVTADLQTILDEHRPEVVFHLAAQIDVRHSVVDPQFDASVNVIGTVRLAEAAR--HTGVR 119
Query: 119 -LVHISTD-EVYGDILKGSFTEEDRLMPSSPYSATKAASDMLVLGWARTYGLNASITRCT 176
+VH S+ +YG + E P+SPY+A K A ++ + + GL+ S
Sbjct: 120 KIVHTSSGGSIYGTPSQYPTPETVPTDPTSPYAAGKVAGEIYLNTFRHLCGLDCSHIAPA 179
Query: 177 NNYGPYQFP--EKLIPKTIIRAKMGLK-VPIYGTGKNVRDWLYVEDHVRAIEAVLLKGEA 233
N YGP Q P E + ++A + + ++G G + RD+++V+D V A
Sbjct: 180 NVYGPRQDPYGEAGVVAIFVQALLSDRPTKVFGDGTHTRDYVFVDDVVDAFIKASGDAGG 239
Query: 234 REIYNISAGEERTNLEVVRTILRIMDKDESLIEFVEDRPGHDIRYSLDSWKIIRELKWRP 293
+ +NI G E ++ ++ + + + EF R G R LD L W P
Sbjct: 240 GQRFNIGTGIETSDRQLHTAVSAAVGGPDD-PEFHPPRLGDLKRSCLDIGLATTVLGWSP 298
Query: 294 KYRFEEGIKKTVEWY 308
+ + ++G+++TVE++
Sbjct: 299 QVQLDDGVRRTVEYF 313
>pir||A69184 UDP-glucose 4-epimerase - Methanobacterium thermoautotrophicum
(strain Delta H) >gi|2621713|gb|AAB85137.1| (AE000844)
UDP-glucose 4-epimerase [Methanobacterium
thermoautotrophicum]
Length = 325
Score = 111 bits (276), Expect = 9e-24
Identities = 97/337 (28%), Positives = 162/337 (47%), Gaps = 46/337 (13%)
Query: 3 ILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRY-TFVKGDVA 61
IL+ GG G+IGS+ +++ E+ +E + LD LT G +D ++ F++G++
Sbjct: 2 ILIVGGAGYIGSHVNKFLSER--GYETLILDNLTRGH--------RDFVKWGEFIEGNLG 51
Query: 62 DFELVRELIKK--VDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKENPGVR- 118
D L+ + VDA++HFAA + V S+ P + H+NV+ T LL+++ + GVR
Sbjct: 52 DRRLLDRTFETHDVDAVMHFAAFTDVGESVLKPGRYYHNNVVNTINLLDSM--VDHGVRD 109
Query: 119 LVHISTDEVYGDILKGSFTEEDRLMPSSPYSATKAASDMLVLGWARTYGLNASITRCTN- 177
+ ST VYG+ ++ +EE L P SPY +K + ++ + YGLN R N
Sbjct: 110 FIFSSTCAVYGNPMEIPISEEHPLNPISPYGRSKLMVEEILGDYRDAYGLNYVSLRYFNA 169
Query: 178 -------NYGPYQFPEKLIPKTIIRAKMGLK--VPIYGT------GKNVRDWLYVED--- 219
G PE + ++ +GL+ V I+GT G VRD+++V D
Sbjct: 170 AGADPEGEVGELHNPETHLIPIVLDVALGLRDAVRIFGTDYPTPDGTCVRDYIHVMDLAD 229
Query: 220 -HVRAIEAVLLKGEAREIYNISAGEERTNLEVVRTILRIMDKDESLIEFVEDRPGHDIRY 278
H RA+ L+G ++N+ G + +EV+ T + + +E + RPG
Sbjct: 230 AHWRALR--YLEGGESGVFNLGNGNGFSVMEVIETCREVTGASINAVE-DDRRPGDPPEL 286
Query: 279 SLDSWKIIRELKWRPKYRFEEGIKKTVEWYLENEWWW 315
+ + R L WRP++ E I +E W W
Sbjct: 287 VGSAGRARRVLGWRPEFTELEDI-------IETAWNW 316
>pir||B33604 rfbE protein - Salmonella sp
Length = 348
Score = 111 bits (274), Expect = 2e-23
Identities = 79/247 (31%), Positives = 119/247 (47%), Gaps = 28/247 (11%)
Query: 1 MRILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDV 60
M++L+TGG GF+GSN + L + D +I D L+ NL + + FV GD+
Sbjct: 1 MKLLITGGCGFLGSNLASFALSQGID--LIVFDNLSRKGATDNLHWLSSLGNFEFVHGDI 58
Query: 61 ADFELVRELIKKV--DAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKENPGVR 118
+ V LI K D+ H A + + SI +P NV GT LLEA+R+ N
Sbjct: 59 RNKNDVTRLITKYMPDSCFHLAGQVAMTTSIDNPCMDFEINVGGTLNLLEAVRQYNSNCN 118
Query: 119 LVHISTDEVYGDILK----------------GSFTEEDRLMPSSPYSATKAASDMLVLGW 162
+++ ST++VYGD+ + + E +L SPY +K A+D +L +
Sbjct: 119 IIYSSTNKVYGDLEQYKYNETETRYTCVDKPNGYDESTQLDFHSPYGCSKGAADQYMLDY 178
Query: 163 ARTYGLNASITRCTNNYGPYQFPE------KLIPKTIIRAKMGLKVP--IYGTGKNVRDW 214
AR +GLN + R ++ YG QF + + K G+ P I G GK VRD
Sbjct: 179 ARIFGLNTVVFRHSSMYGGRQFATYDQGWVGWFCQKAVEIKNGINKPFTISGNGKQVRDV 238
Query: 215 LYVEDHV 221
L+ ED +
Sbjct: 239 LHAEDMI 245
>gb|AAF36926.1|AF221951_2 (AF221951) putative UDP-galactose 4-epimerase GalE [Rhodococcus
erythropolis]
Length = 329
Score = 111 bits (274), Expect = 2e-23
Identities = 98/316 (31%), Positives = 152/316 (48%), Gaps = 37/316 (11%)
Query: 1 MRILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDV 60
M++LVTGG G++GS +LE+ + EV+ +D L+ G+ A + F++GDV
Sbjct: 1 MKLLVTGGAGYVGSVCSTVLLERGH--EVVVIDDLSTGNADAVPAGAE------FIEGDV 52
Query: 61 ADFELVRELIKKV-----DAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKENP 115
L +++ D ++HFAA+S V S+ P+ + NV+ T LLEAIR
Sbjct: 53 G--ALAADVLGSAGSPVFDGVLHFAAQSLVGESVLHPEKYWRGNVVTTIELLEAIRVSGT 110
Query: 116 GVRLVHISTDEVYGDILKGSFTEEDRLMPSSPYSATKAASDMLVLGWARTYGLNASITRC 175
RLV ST YG+ + E P++PY ATK A D + ++ +GL A+ R
Sbjct: 111 P-RLVFSSTAATYGEPEQSPIVETAPTRPTNPYGATKLAIDHAITSYSIAHGLGATSLRY 169
Query: 176 TNNYGPYQ-------FPEKLIPKTI-IRAKMGLKVPIYGT------GKNVRDWLYV---- 217
N G Y+ LIP + + + K+ ++GT G VRD+++V
Sbjct: 170 FNVAGAYKSAGENRVIETHLIPLVLQVALEQRDKISVFGTDWPTPDGTAVRDYIHVLDLA 229
Query: 218 EDHVRAIEAVLLKGEAREIYNISAGEERTNLEVVRTILRIMDKDESLIEFVEDRPGHDIR 277
E H+ A+E+ + GE R IYN+ +G + EV+ R+ + +E R G
Sbjct: 230 EAHLLALES-SVPGEHR-IYNLGSGAGFSVREVIAACARVTGLPIN-VEDASRRLGDPAV 286
Query: 278 YSLDSWKIIRELKWRP 293
S K I EL W P
Sbjct: 287 LIASSDKAIAELGWTP 302
>gb|AAD50494.1|AF172324_12 (AF172324) WbnF [Escherichia coli]
Length = 334
Score = 110 bits (273), Expect = 2e-23
Identities = 91/332 (27%), Positives = 158/332 (47%), Gaps = 28/332 (8%)
Query: 1 MRILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLK----DIQDDPRYTFV 56
M+ LVTG GFIG + +L + +V+ +D L NLK D+ ++F
Sbjct: 1 MKFLVTGAAGFIGFYVSKRLLAAGH--QVVGIDNLN-DYYDVNLKQARLDLLKHDNFSFY 57
Query: 57 KGDVADFELVRELI--KKVDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKEN 114
K D+AD E + L ++ D +++ AA++ V S+ +P+ + +N+IG +LE R N
Sbjct: 58 KIDLADREKMAALFADERFDRVINLAAQAGVRYSLENPNAYADANLIGFLNILEGCRHNN 117
Query: 115 PGVRLVHISTDEVYGDILKGSFTEEDRL-MPSSPYSATKAASDMLVLGWARTYGLNASIT 173
L++ S+ VYG K F+ +D + P S Y+ATK A++++ ++ YGL +
Sbjct: 118 VQ-HLLYASSSSVYGMNRKMPFSTDDSVDHPVSLYAATKKANELMAHTYSHLYGLPTTGL 176
Query: 174 RCTNNYGPYQFPEKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRAIEAVL-LKGE 232
R YGP+ P+ + K G + +Y GK RD+ Y++D AI + + E
Sbjct: 177 RFFTVYGPWGRPDMALFKFTKAMLEGKSIDVYNFGKMKRDFTYIDDIAEAIIRLQDVIPE 236
Query: 233 AREIYNISAGEERTNLEVVRTI-------LRIMDKDESLIE---------FVEDRPGHDI 276
+ + G T+ R + +MD +L E + +PG +
Sbjct: 237 KDPQWTVETGSPATSSAPYRVYNIGNSSPVELMDYINALEEALGIEANKNMMPLQPGDVL 296
Query: 277 RYSLDSWKIIRELKWRPKYRFEEGIKKTVEWY 308
S D+ + + ++P+ +EG+K VEWY
Sbjct: 297 ETSADTKALYDVIGFKPETSVKEGVKNFVEWY 328
>gb|AAG35361.1|AF317224_3 (AF317224) GDP-6-deoxy-D-lyxo-4-hexulose reductase
[Aneurinibacillus thermoaerophilus]
Length = 309
Score = 110 bits (272), Expect = 3e-23
Identities = 90/319 (28%), Positives = 163/319 (50%), Gaps = 24/319 (7%)
Query: 1 MRILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDV 60
MR L+TG GF+G ++ E++ EV + +N A L +++ + D+
Sbjct: 1 MRALITGVAGFVGKYLANHLTEQNV--EVFGTSR----NNEAKLPNVE------MISLDI 48
Query: 61 ADFELVRELIK--KVDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKENPGVR 118
D + V+++I K D I H AA+S V S + +NV GT +L+A+R N R
Sbjct: 49 MDSQRVKKVISDIKPDYIFHLAAKSSVKDSWLNKKGTFSTNVFGTLHVLDAVRDSNLDCR 108
Query: 119 LVHISTDEVYGDIL--KGSFTEEDRLMPSSPYSATKAASDMLVLGWARTYGLNASITRCT 176
++ I + E YG IL + +EE++L P SPY +KA+ ML + + YG++ TR
Sbjct: 109 ILTIGSSEEYGMILPEESPVSEENQLRPMSPYGVSKASVGMLARQYVKAYGMDIIHTRTF 168
Query: 177 NNYGPYQ---FPEKLIPKTIIRAKMGLKVPIYGTG--KNVRDWLYVEDHVRAIEAVLLKG 231
N+ GP Q F + K I+ +M + PI G + VRD+ V D V+A + G
Sbjct: 169 NHIGPGQSLGFVTQDFAKQIVDIEMEKQEPIIKVGNLEAVRDFTDVRDIVQAYWLLSQYG 228
Query: 232 EAREIYNISAGEERTNLEVVRTILRIMD-KDESLIEFVEDRPGHDIRYSLDSWKIIRE-L 289
+ ++YN+ +G +V+ +L + + K ++ + ++ RP ++ + S K +++
Sbjct: 229 KTGDVYNVCSGIGTRIQDVLDLLLAMANVKIDTELNPLQLRPS-EVPTLIGSNKRLKDST 287
Query: 290 KWRPKYRFEEGIKKTVEWY 308
W+P+ E+ + + ++ Y
Sbjct: 288 GWKPRIPLEKSLFEILQSY 306
>sp|P33119|GALE_CORDI UDP-GLUCOSE 4-EPIMERASE (GALACTOWALDENASE) (UDP-GALACTOSE
4-EPIMERASE) >gi|144973|gb|AAA23297.1| (M34239) ORF3
[Corynebacterium diphtheriae] >gi|144977|gb|AAA23300.1|
(M80338) open reading frame [Corynebacterium
diphtheriae]
Length = 328
Score = 109 bits (271), Expect = 3e-23
Identities = 92/313 (29%), Positives = 150/313 (47%), Gaps = 32/313 (10%)
Query: 1 MRILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDV 60
M++LVTGG G++GS +LE+ + EV +D LT G+ A TFV+GD+
Sbjct: 1 MKLLVTGGAGYVGSVCSTVLLEQGH--EVTIVDNLTTGNRDAVPLGA------TFVEGDI 52
Query: 61 ADFELVRELIKKVDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKENPGVRLV 120
D DA++HFAA S V S+ PD + N++ T LL+A+++ N +V
Sbjct: 53 KDVAENVLSSDSFDAVLHFAARSLVGESVEKPDEYWQHNMVTTLALLDAMKRNNVR-NIV 111
Query: 121 HISTDEVYGDILKGSFTEEDRLMPSSPYSATKAASDMLVLGWARTYGLNASITRCTNNYG 180
ST YG+ TE+ P++PY ATK + D + +A YG A+ R N G
Sbjct: 112 FSSTAATYGEPETVPITEDAPTHPTNPYGATKLSIDYAITSYAHAYGFAATSLRYFNVAG 171
Query: 181 PY-------QFPEKLIPKTIIRAKMGLKVPIYGTGKN--------VRDWLYVED----HV 221
Y + LIP +++ +G + I+ G + +RD++++ D H+
Sbjct: 172 AYGLVGENREIETHLIP-LVLQVALGHRDKIFMFGDDWPTEDGTPIRDYIHIRDLADAHI 230
Query: 222 RAIEAVLLKGEAREIYNISAGEERTNLEVVRTILRIMDKDESLIEFVEDRPGHDIRYSLD 281
A+++ ++G R I+N+ +GE + +V+ T R + E R G
Sbjct: 231 LALQS-NVEGSHR-IFNLGSGEGYSVKQVIDT-CREVTGHPIPAEVAPRRAGDPAVLIAS 287
Query: 282 SWKIIRELKWRPK 294
S K EL W+P+
Sbjct: 288 SAKAQSELGWKPQ 300
>sp|O84903|GALE_LACCA UDP-GLUCOSE 4-EPIMERASE (GALACTOWALDENASE) (UDP-GALACTOSE
4-EPIMERASE) >gi|3201657|gb|AAC19329.1| (AF005933)
UDP-galactose 4-epimerase [Lactobacillus casei]
Length = 331
Score = 109 bits (271), Expect = 3e-23
Identities = 100/339 (29%), Positives = 154/339 (44%), Gaps = 44/339 (12%)
Query: 1 MRILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDV 60
M I V GG G+IGS+ ++ +L D V+ LD L G A DPR F +GD+
Sbjct: 1 MTIAVLGGAGYIGSHTVKQLLAAGED--VVVLDNLITGHRKAV------DPRARFYQGDI 52
Query: 61 ADFELVRELI--KKVDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKENPGV- 117
D+ + ++ +K+D IVHFAA S V S+ P + +N G TLLEA+ + G+
Sbjct: 53 RDYHFLSQVFSQEKIDGIVHFAAFSIVPESMKDPLKYFDNNTGGMITLLEAMNQF--GIK 110
Query: 118 RLVHISTDEVYGDILKGSFTEEDRLMPSSPYSATKAASDMLVLGWAR-TYGLNASITRCT 176
++V ST YG+ + E D +P++PY +K A + ++ WA YGL R
Sbjct: 111 KIVFSSTAATYGEPKQVPIKETDPQVPTNPYGESKLAMEK-IMHWADVAYGLKFVALRYF 169
Query: 177 N--------NYGPYQFPEKLIPKTIIRAKMGLK--VPIYG------TGKNVRDWLYVED- 219
N + G PE I I++ G + + IYG G NVRD+++V D
Sbjct: 170 NVAGAMPDGSIGEDHHPETHIVPIILQVAAGTRTGLQIYGDDYPTKDGTNVRDYVHVVDL 229
Query: 220 ---HVRAIEAVLLKGEAREIYNISAGEERTNLEVVRTILRIMDKDESLIEFVEDRPGHDI 276
H+ A++ L G +NI + +NLE++ ++ + E R G
Sbjct: 230 ADAHILALK-YLDAGNKSSAFNIGSAHGFSNLEILNAARKVTGQ-EIPATMGPRRAGDPS 287
Query: 277 RYSLDSWKIIRELKWRPKYRFEEGIKKTVEWYLENEWWW 315
S K L W+P Y ++ +E W W
Sbjct: 288 TLIASSEKARDILGWKPNY-------DDIDKIIETAWNW 319
>pir||T51252 dTDPglucose 4,6-dehydratase (EC 4.2.1.46) [imported] - chickpea
>gi|6469141|emb|CAB61752.1| (AJ275318) dTDP-glucose
4-6-dehydratase [Cicer arietinum]
Length = 346
Score = 109 bits (269), Expect = 6e-23
Identities = 91/308 (29%), Positives = 145/308 (46%), Gaps = 18/308 (5%)
Query: 1 MRILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDV 60
MRILVTGG GFIGS+ + ++E + EVI D GS NLK PR+ ++ DV
Sbjct: 33 MRILVTGGAGFIGSHLVDRLMENEKN-EVIVADNYFTGSKD-NLKKWIGHPRFELIRHDV 90
Query: 61 ADFELVRELIKKVDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKENPGVRLV 120
+ L+ +VD I H A + +P + +NVIGT +L ++ G R++
Sbjct: 91 TE-----PLMIEVDQIYHLACPASPIFYKYNPVKTIKTNVIGTLNMLGLAKR--VGARIL 143
Query: 121 HISTDEVYGDILKGSFTEE--DRLMPS---SPYSATKAASDMLVLGWARTYGLNASITRC 175
ST EVYGD L+ TE + P+ + Y K ++ L+ + R +G+ + R
Sbjct: 144 LTSTSEVYGDPLEHPQTESYWGNVNPNGVRNCYDEGKRVAETLMFDYHRQHGIEIRVARI 203
Query: 176 TNNYGPYQFPE--KLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRAIEAVLLKGEA 233
N YGP + +++ I +A G + + G R + YV D V + L+ G
Sbjct: 204 FNTYGPRMNIDDGRVVSNFIAQALRGESLTVQSPGTQTRSFCYVSDLVDGL-IRLMGGSD 262
Query: 234 REIYNISAGEERTNLEVVRTILRIMDKDESLIEFVEDRPGHDIRYSLDSWKIIRELKWRP 293
N+ E T LE+ T+ +++ + I+ VE+ P + D K L W P
Sbjct: 263 TGPINLGNPGEFTMLELAETVKELINPNVE-IKTVENTPDDPRQRKPDITKAKELLGWEP 321
Query: 294 KYRFEEGI 301
K + +G+
Sbjct: 322 KVKLRDGL 329
>sp|P39858|CAPI_STAAU CAPI PROTEIN >gi|506705|gb|AAA64648.1| (U10927) CapI
[Staphylococcus aureus]
Length = 334
Score = 108 bits (268), Expect = 8e-23
Identities = 84/335 (25%), Positives = 163/335 (48%), Gaps = 30/335 (8%)
Query: 1 MRILVTGGMGFIGSNFIRYILEKHNDWEVINLDKL----TYGSNPANLKDIQDDPRYTFV 56
M+IL+TG GFIGS+ + ++++ + VI +D + + LK I + +TF
Sbjct: 1 MKILITGTAGFIGSHLAKKLIKQGH--YVIGVDSINDYYSVSLKEDRLKSIGKE-NFTFN 57
Query: 57 KGDVADFELVRELI--KKVDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKEN 114
K + +++ + ++ ++ + +V+ AA++ V SI +P ++ SN++G +LE R N
Sbjct: 58 KVKLENYDDLSKVFVDEQPEVVVNLAAQAGVRYSIENPRTYIDSNIVGFMNILECSRHFN 117
Query: 115 PGVRLVHISTDEVYGDILKGSFTEEDRL-MPSSPYSATKAASDMLVLGWARTYGLNASIT 173
L++ S+ VYG F+ D + P S Y+ATK +++++ ++ Y L +
Sbjct: 118 I-QNLIYASSSSVYGANTSKPFSTSDNIDHPLSLYAATKKSNELMAHTYSHLYNLPTTGL 176
Query: 174 RCTNNYGPYQFPEKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRAIEAVLLKGEA 233
R YGP+ P+ + K + +Y G +RD+ YV+D V AI ++ K +
Sbjct: 177 RFFTVYGPWGRPDMALFKFTKAIVNDQAIDVYNHGNMMRDFTYVDDIVEAISRLVKKPAS 236
Query: 234 ------------------REIYNISAGEERTNLEVVRTILRIMDKDESLIEFVEDRPGHD 275
++YNI +E V I + K E+ +++ +PG
Sbjct: 237 PNKEWSGADPDPGSSYAPYKVYNIGNNSPVRLMEFVEAIENKLGK-EARKNYMDLQPGDV 295
Query: 276 IRYSLDSWKIIRELKWRPKYRFEEGIKKTVEWYLE 310
+ + R++ ++P+ ++G+ K V+WYLE
Sbjct: 296 PETYANVDDLFRDIDFKPETTIQDGVNKFVDWYLE 330
>sp|P55180|GALE_BACSU UDP-GLUCOSE 4-EPIMERASE (GALACTOWALDENASE) (UDP-GALACTOSE
4-EPIMERASE) >gi|7437225|pir||D69628 UDPglucose
4-epimerase (EC 5.1.3.2) - Bacillus subtilis
>gi|1429254|emb|CAA67713.1| (X99339) UDP-glucose
4-epimerase [Bacillus subtilis]
>gi|1783241|dbj|BAA11718.1| (D83026) highly homologous
to UDP-glucose 4-epimerases (SwissProt:GALE_HAEIN and
GALE_ECOLI); hypothetical [Bacillus subtilis]
>gi|2636421|emb|CAB15912.1| (Z99123) UDP-glucose
4-epimerase [Bacillus subtilis]
Length = 339
Score = 108 bits (268), Expect = 8e-23
Identities = 99/339 (29%), Positives = 160/339 (46%), Gaps = 36/339 (10%)
Query: 1 MRILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPA--NLKDIQDDPRYTFVKG 58
M ILVTGG G+IGS+ +L ++ +E++ LD L+ S A +K+I TF +
Sbjct: 1 MAILVTGGAGYIGSHTCVELL--NSGYEIVVLDNLSNSSAEALNRVKEITGKD-LTFYEA 57
Query: 59 DVADFELVRELI--KKVDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKENPG 116
D+ D E V + +++A++HFA V S++ P + H+N+ GT+ L EA+ K G
Sbjct: 58 DLLDREAVDSVFAENEIEAVIHFAGLKAVGESVAIPLKYYHNNLTGTFILCEAMEKY--G 115
Query: 117 V-RLVHISTDEVYGDILKGSFTEEDRLMPSSPYSATKAASDMLVLG-WARTYGLNASITR 174
V ++V S+ VYG TE+ L ++PY TK + ++ + ++ R
Sbjct: 116 VKKIVFSSSATVYGVPETSPITEDFPLGATNPYGQTKLMLEQILRDLHTADNEWSVALLR 175
Query: 175 CTNNYG----------PYQFPEKLIPKTIIRAKMGL--KVPIYGT------GKNVRDWLY 216
N +G P P L+P + + +G ++ ++G G VRD+++
Sbjct: 176 YFNPFGAHPSGRIGEDPNGIPNNLMP-YVAQVAVGKLEQLSVFGNDYPTKDGTGVRDYIH 234
Query: 217 V----EDHVRAIEAVLLKGEAREIYNISAGEERTNLEVVRTILRIMDKDESLIEFVEDRP 272
V E HV+A+E V L + YN+ G + LE+V+ ++ K E F + RP
Sbjct: 235 VVDLAEGHVKALEKV-LNSTGADAYNLGTGTGYSVLEMVKAFEKVSGK-EVPYRFADRRP 292
Query: 273 GHDIRYSLDSWKIIRELKWRPKYRFEEGIKKTVEWYLEN 311
G D K REL W K EE + W N
Sbjct: 293 GDIATCFADPAKAKRELGWEAKRGLEEMCADSWRWQSSN 331
>pir||T45701 dTDP-glucose 4-6-dehydratases-like protein - Arabidopsis thaliana
>gi|6522623|emb|CAB62035.1| (AL133298) dTDP-glucose
4-6-dehydratases-like protein [Arabidopsis thaliana]
Length = 341
Score = 108 bits (267), Expect = 1e-22
Identities = 89/308 (28%), Positives = 144/308 (45%), Gaps = 18/308 (5%)
Query: 1 MRILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDV 60
MRIL++GG GFIGS+ + ++E + EVI D GS NLK PR+ ++ DV
Sbjct: 29 MRILISGGAGFIGSHLVDKLMENEKN-EVIVADNYFTGSKD-NLKKWIGHPRFELIRHDV 86
Query: 61 ADFELVRELIKKVDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKENPGVRLV 120
+ L+ +VD I H A + +P + +NVIGT +L ++ G R++
Sbjct: 87 TE-----PLLIEVDQIYHLACPASPIFYKYNPVKTIKTNVIGTLNMLGLAKR--VGARIL 139
Query: 121 HISTDEVYGDIL-----KGSFTEEDRLMPSSPYSATKAASDMLVLGWARTYGLNASITRC 175
ST EVYGD L + + + + S Y K ++ L+ + R +G+ I R
Sbjct: 140 LTSTSEVYGDPLIHPQPESYWGNVNPIGVRSCYDEGKRVAETLMFDYHRQHGIEIRIARI 199
Query: 176 TNNYGPYQFPE--KLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRAIEAVLLKGEA 233
N YGP + +++ I +A G + + G R + YV D V + L++G+
Sbjct: 200 FNTYGPRMNIDDGRVVSNFIAQALRGEALTVQKPGTQTRSFCYVSDMVDGLMR-LMEGDD 258
Query: 234 REIYNISAGEERTNLEVVRTILRIMDKDESLIEFVEDRPGHDIRYSLDSWKIIRELKWRP 293
NI E T +E+ T+ +++ I+ VE+ P + D K L W P
Sbjct: 259 TGPINIGNPGEFTMVELAETVKELINPSIE-IKMVENTPDDPRQRKPDITKAKEVLGWEP 317
Query: 294 KYRFEEGI 301
K + EG+
Sbjct: 318 KVKLREGL 325
>gb|AAG26471.1|AF285774_11 (AF285774) putative UDP-glucuronic acid epimerase [Bacteroides
fragilis]
Length = 350
Score = 108 bits (266), Expect = 1e-22
Identities = 91/354 (25%), Positives = 167/354 (46%), Gaps = 52/354 (14%)
Query: 1 MRILVTGGMGFIGSNFIRYILEKHNDWEVINLDK--------LTYGSNPANLKDIQDD-- 50
M +LVTG GFIGS+ + +L++ + EV+ LD L YG ++L Q +
Sbjct: 1 MNVLVTGAAGFIGSHVCKRLLQRGD--EVVGLDNINSYYDINLKYG-RLSSLGVPQSELS 57
Query: 51 ----------PRYTFVKGDVADFELVRELIKK--VDAIVHFAAESHVDRSISSPDNFLHS 98
PR++FV+ ++ D + ++ L D +++ AA++ V SI +P ++ S
Sbjct: 58 WYKFTRSNVYPRFSFVRMNLEDRQAMQMLFANGNFDVVINLAAQAGVRYSIENPYAYVES 117
Query: 99 NVIGTYTLLEAIRKENPGVRLVHISTDEVYGDILKGSFTEEDRLM-PSSPYSATKAASDM 157
N+ G +LE R LV+ S+ VYG + F+E+D + P S Y+ATK ++++
Sbjct: 118 NIDGFLNVLEGCRHSQVK-HLVYASSSSVYGLNGQVPFSEKDGIAHPVSLYAATKKSNEL 176
Query: 158 LVLGWARTYGLNASITRCTNNYGPYQFPEK---LIPKTIIRAKMGLKVPIYGTGKNVRDW 214
+ ++ Y + ++ R YGP+ P+ L I+ G + ++ G +RD+
Sbjct: 177 MAHTYSHLYNIPSTGLRFFTVYGPWGRPDMSPFLFADAILH---GRPIKVFNNGNMLRDF 233
Query: 215 LYVEDHVRAIEAVL------------------LKGEAREIYNISAGEERTNLEVVRTILR 256
Y++D V + V + +IYNI ++ +R I
Sbjct: 234 TYIDDIVEGVLRVADSIPEGNQCWDAEVADPSMSCAPYKIYNIGNSRPVKLMDFIRAIEM 293
Query: 257 IMDKDESLIEFVEDRPGHDIRYSLDSWKIIRELKWRPKYRFEEGIKKTVEWYLE 310
+ ++ I ++ +PG + D+ + RE+ ++P E G+KKT+ WY E
Sbjct: 294 SIGREADKI-YLPMQPGDVYQTYADTSSLSREIGFQPNTSLEAGVKKTISWYKE 346
>dbj|BAB07428.1| (AP001519) nucleotide sugar epimerase (biosynthesis of
lipopolysaccharide O antigen) [Bacillus halodurans]
Length = 343
Score = 106 bits (263), Expect = 3e-22
Identities = 85/333 (25%), Positives = 160/333 (47%), Gaps = 29/333 (8%)
Query: 1 MRILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPA----NLKDIQDDPRYTFV 56
M+ILVTG GFIG + +LE+ + V+ +D L +P L +++ + F
Sbjct: 1 MKILVTGAAGFIGMYVAKRLLEEGHF--VVGIDNLNDYYDPQLKNDRLLQLRELGNFEFH 58
Query: 57 KGDVADFELVRELI--KKVDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKEN 114
K D+ + + +R+L K++ +++ AA++ V S+ +P ++ SN++G LLE+ R+ N
Sbjct: 59 KMDLTERDRLRQLFLDKEITHVINLAAQAGVRYSLKNPHAYIDSNLVGFTNLLESCRELN 118
Query: 115 PGVRLVHISTDEVYGDILKGSFTEEDRL-MPSSPYSATKAASDMLVLGWARTYGLNASIT 173
L++ S+ VYG K F D + P S Y+ATK A+++L ++ Y + +
Sbjct: 119 V-KHLIYASSSSVYGANRKMPFATSDEVNHPVSLYAATKKANELLAHSYSHLYHIPTTGL 177
Query: 174 RCTNNYGPYQFPEKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRAIEAVLLKGEA 233
R YGP+ P+ G + ++ G+ +RD+ Y++D V + A+L +
Sbjct: 178 RFFTVYGPWGRPDMAYFSFTKNIVEGQTIKVFNHGEMMRDFTYIDDIVDGVVALLEQPPQ 237
Query: 234 RE------------------IYNISAGEERTNLEVVRTILRIMDKDESLIEFVEDRPGHD 275
+ IYNI + ++ + T+ + + E+ EF+ +PG
Sbjct: 238 ADPNWDFEHPMASSSYAPYKIYNIGNNQPVKLMDFIETLEKHLG-IEAKKEFLPMQPGDV 296
Query: 276 IRYSLDSWKIIRELKWRPKYRFEEGIKKTVEWY 308
D + + + P +EG+KK V+W+
Sbjct: 297 QATYADIDDLQQATGFTPSTSIDEGLKKFVDWF 329
>dbj|BAB09774.1| (AB016890) dTDP-glucose 4-6-dehydratase [Arabidopsis thaliana]
Length = 342
Score = 106 bits (262), Expect = 4e-22
Identities = 88/308 (28%), Positives = 143/308 (45%), Gaps = 18/308 (5%)
Query: 1 MRILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDV 60
MRIL++GG GFIGS+ + ++E + EV+ D GS NLK PR+ ++ DV
Sbjct: 30 MRILISGGAGFIGSHLVDKLMENEKN-EVVVADNYFTGSK-ENLKKWIGHPRFELIRHDV 87
Query: 61 ADFELVRELIKKVDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKENPGVRLV 120
+ L+ +VD I H A + +P + +NVIGT +L ++ G R++
Sbjct: 88 TE-----PLLIEVDRIYHLACPASPIFYKYNPVKTIKTNVIGTLNMLGLAKR--VGARIL 140
Query: 121 HISTDEVYGDIL-----KGSFTEEDRLMPSSPYSATKAASDMLVLGWARTYGLNASITRC 175
ST EVYGD L + + + + S Y K ++ L+ + R +G+ I R
Sbjct: 141 LTSTSEVYGDPLIHPQPESYWGNVNPIGVRSCYDEGKRVAETLMFDYHRQHGIEIRIARI 200
Query: 176 TNNYGPYQFPE--KLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRAIEAVLLKGEA 233
N YGP + +++ I +A G + + G R + YV D V + L++G
Sbjct: 201 FNTYGPRMNIDDGRVVSNFIAQALRGEALTVQKPGTQTRSFCYVSDMVDGL-IRLMEGND 259
Query: 234 REIYNISAGEERTNLEVVRTILRIMDKDESLIEFVEDRPGHDIRYSLDSWKIIRELKWRP 293
NI E T +E+ T+ +++ I+ VE+ P + D K L W P
Sbjct: 260 TGPINIGNPGEFTMVELAETVKELINPSIE-IKMVENTPDDPRQRKPDISKAKEVLGWEP 318
Query: 294 KYRFEEGI 301
K + EG+
Sbjct: 319 KVKLREGL 326
>sp|Q45291|GALE_BRELA UDP-GLUCOSE 4-EPIMERASE (GALACTOWALDENASE) (UDP-GALACTOSE
4-EPIMERASE) >gi|2144276|pir||JC5168 UDPglucose
4-epimerase (EC 5.1.3.2) - Corynebacterium glutamicum
>gi|1161517|emb|CAA89986.1| (Z49823) UDP-galactose
4-epimease [Corynebacterium glutamicum]
Length = 329
Score = 104 bits (257), Expect = 2e-21
Identities = 91/314 (28%), Positives = 147/314 (45%), Gaps = 32/314 (10%)
Query: 1 MRILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDV 60
M++LVTGG G++GS +LE +D +I D + G+ A D + ++GDV
Sbjct: 1 MKLLVTGGAGYVGSVRAAVLLEHGHDVTII--DNFSTGNREAVPADAR------LIEGDV 52
Query: 61 ADFELVRELIKK--VDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKENPGVR 118
D +V E++ + + +VHFAA S V S+ P+ + H NV+ TLL+A+R
Sbjct: 53 ND--VVEEVLLEGGFEGVVHFAARSLVGESVEKPNEYWHDNVVTALTLLDAMRAHGVN-N 109
Query: 119 LVHISTDEVYGDILKGSFTEEDRLMPSSPYSATKAASDMLVLGWARTYGLNASITRCTNN 178
LV ST YG+ TE+ P++ Y ATK + D + +A +GL A+ R N
Sbjct: 110 LVFSSTAATYGEPDVVPITEDMPTQPTNAYGATKLSIDYAITSYAAAFGLAATSLRYFNV 169
Query: 179 YGPY-------QFPEKLIPKTIIRAKMGLKVPIYGTGKN--------VRDWLYVEDHVRA 223
G Y + LIP +++ G + I+ G + VRD++++ D +A
Sbjct: 170 AGAYGNIGENREVETHLIP-LVLQVATGHREKIFMFGDDWPTPDGTAVRDYIHILDLAKA 228
Query: 224 IEAVLLKGEA--REIYNISAGEERTNLEVVRTILRIMDKDESLIEFVEDRPGHDIRYSLD 281
L EA I+N+ +G+ + +VV + R + E R G
Sbjct: 229 HVLALESNEAGKHRIFNLGSGDGYSVKQVVE-MCREVTGHPIPAEVAPRRAGDPATLIAS 287
Query: 282 SWKIIRELKWRPKY 295
S K +EL W P++
Sbjct: 288 SEKAKQELGWTPEH 301
>emb|CAC14890.1| (AJ295156) d-TDP-glucose dehydratase [Phragmites australis]
Length = 350
Score = 104 bits (257), Expect = 2e-21
Identities = 89/308 (28%), Positives = 139/308 (44%), Gaps = 18/308 (5%)
Query: 1 MRILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDV 60
+RILVTGG GFIGS+ + ++E EVI D GS NLK PR+ ++ DV
Sbjct: 35 LRILVTGGAGFIGSHLVDKLMENEKH-EVIVADNFFTGSKD-NLKKWIGHPRFELIRHDV 92
Query: 61 ADFELVRELIKKVDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKENPGVRLV 120
+ L+ +VD I H A + +P + +NVIGT +L ++ G R++
Sbjct: 93 -----TQPLLVEVDQIYHLACPASPIFYKHNPVKTIKTNVIGTLNMLGLAKR--VGARIL 145
Query: 121 HISTDEVYGDILKGSFTEE-----DRLMPSSPYSATKAASDMLVLGWARTYGLNASITRC 175
ST EVYGD L+ TE + + S Y K ++ L+ + R +G+ I R
Sbjct: 146 LTSTSEVYGDPLEHPQTEAYWGNVNPIGVRSCYDEGKRVAETLMFDYHRQHGIEIRIARI 205
Query: 176 TNNYGPYQFPE--KLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRAIEAVLLKGEA 233
N YGP + +++ I +A G + + G R + YV D V + L+ G
Sbjct: 206 FNTYGPRMNIDDGRVVSNFIAQAVRGDPLTVQKPGTQTRSFCYVADMVDGL-IKLMNGNN 264
Query: 234 REIYNISAGEERTNLEVVRTILRIMDKDESLIEFVEDRPGHDIRYSLDSWKIIRELKWRP 293
N+ E T LE+ + +++ E + E+ P + D K L W P
Sbjct: 265 TGPINLGNPGEFTMLELAEKVKELIN-PEVTVTMTENTPDDPRQRKPDITKAKEVLGWEP 323
Query: 294 KYRFEEGI 301
K +G+
Sbjct: 324 KVVLRDGL 331
>pir||T48135 nucleotide sugar epimerase-like protein - Arabidopsis thaliana
>gi|5281036|emb|CAB45972.1| (AL080318) nucleotide sugar
epimerase-like protein [Arabidopsis thaliana]
>gi|7267926|emb|CAB78268.1| (AL161533) nucleotide sugar
epimerase-like protein [Arabidopsis thaliana]
Length = 436
Score = 103 bits (255), Expect = 3e-21
Identities = 92/332 (27%), Positives = 158/332 (46%), Gaps = 26/332 (7%)
Query: 1 MRILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQ---DDPRYTFVK 57
+ +LVTG GF+G++ + L + D V+ LD +P + Q + V+
Sbjct: 96 LTVLVTGASGFVGTH-VSIALRRRGDG-VLGLDNFNRYYDPKLKRARQGLLERSGVFVVE 153
Query: 58 GDVADFELVRELIKKV--DAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKENP 115
GD+ D L+R+L V ++H AA++ V ++ +P ++++SN+ G LLE + NP
Sbjct: 154 GDINDAVLLRKLFDVVLFTHVMHLAAQAGVRYAMQNPGSYVNSNIAGFVNLLEVSKSANP 213
Query: 116 GVRLVHISTDEVYGDILKGSFTEEDRL-MPSSPYSATKAASDMLVLGWARTYGLNASITR 174
+V S+ VYG K F+E+DR P+S Y+ATK A + + + YGL+ + R
Sbjct: 214 QPAIVWASSSSVYGLNSKVPFSEKDRTDQPASLYAATKKAGEGIAHTYNHIYGLSLTGLR 273
Query: 175 CTNNYGPYQFPEK---LIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRAIEAVL--- 228
YGP+ P+ K I++ K G RD+ Y++D V+ L
Sbjct: 274 FFTVYGPWGRPDMAYFFFTKDILKGKTITVFESPDKGSVARDFTYIDDIVKGCLGALDTA 333
Query: 229 ---------LKGEAR-EIYNISAGEERTNLEVVRTILRIMDKDESLIEFVEDRPGHDIRY 278
KG A IYN+ ++V TIL + K ++ + + D+ +
Sbjct: 334 EKSTGSGGKKKGPAMFRIYNLGNTSPVPVTKLV-TILEKLLKMKAKKKIMPLPRNGDVEF 392
Query: 279 SLDSWKIIR-ELKWRPKYRFEEGIKKTVEWYL 309
+ + + + EL ++P E G+KK V+WY+
Sbjct: 393 THANITLAQAELGYKPAVDLETGLKKFVKWYM 424
>gb|AAG16750.1|AF277002_2 (AF277002) UDP-galactose 4-epimerase GalE [Rhodococcus equi]
Length = 283
Score = 103 bits (255), Expect = 3e-21
Identities = 85/267 (31%), Positives = 137/267 (50%), Gaps = 39/267 (14%)
Query: 1 MRILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDV 60
MR+LVTGG G++GS +LE+ + EV+ +D L+ G+ A + F++GD+
Sbjct: 1 MRLLVTGGAGYVGSVCTTVLLERGH--EVVVVDDLSTGNADAVPAGAE------FIEGDI 52
Query: 61 ADFELVRELI------KKVDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKEN 114
A + ++ + D ++HFAA+S V S+ P+ + NV+ T LLEA+R
Sbjct: 53 A--AVAGSVLGSGNSTPRFDGVLHFAAQSLVGESVERPEQYWQGNVVTTLALLEAMRLSG 110
Query: 115 PGVRLVHISTDEVYGDILKGSFTEEDRLMPSSPYSATKAASDMLVLGWARTYGLNASITR 174
RLV ST YG+ + TE+ P++PY ATK A D + +A + L A+ R
Sbjct: 111 TP-RLVFSSTAATYGEPERTPITEDAPTRPTNPYGATKLAIDHAITSYANAHSLAATSLR 169
Query: 175 CTNNYGPYQ-------FPEKLIPKTIIRAKMGL--KVPIYGT------GKNVRDWLYVED 219
N G Y+ LIP +++ +G K+ ++GT G VRD+++V D
Sbjct: 170 YFNVAGAYRGAGENRVVETHLIP-LVLQVALGQREKISVFGTDWPTKDGTAVRDYIHVLD 228
Query: 220 ----HVRAIEAVLLKGEAREIYNISAG 242
H+ A+E+ + G R IYN+ +G
Sbjct: 229 LADAHLLALES-SVPGHHR-IYNLGSG 253
>pdb|1KVS| Udp-Galactose 4-Epimerase Complexed With Udp-Phenol
Length = 338
Score = 102 bits (252), Expect = 6e-21
Identities = 101/344 (29%), Positives = 157/344 (45%), Gaps = 43/344 (12%)
Query: 1 MRILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQ--DDPRYTFVKG 58
MR+LVTGG G+IGS+ +L+ +D VI LD L S + L I+ TFV+G
Sbjct: 1 MRVLVTGGSGYIGSHTCVQLLQNGHD--VIILDNLC-NSKRSVLPVIERLGGKHPTFVEG 57
Query: 59 DVADFELVRELIKK--VDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKENPG 116
D+ + L+ E++ +D ++HFA V S+ P + +NV GT L+ A+R N
Sbjct: 58 DIRNEALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAANV- 116
Query: 117 VRLVHISTDEVYGDILKGSFTEE-DRLMPSSPYSATKAASDMLVLGWARTY-GLNASITR 174
+ ST VYGD K + E P SPY +K + ++ + + ++ R
Sbjct: 117 KNFIFSSTATVYGDNPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQPDWSIALLR 176
Query: 175 CTNNYG----------PYQFPEKLIPKTIIRAKMGLK--VPIYGT------GKNVRDWLY 216
N G P P L+P I + +G + + I+G G VRD+++
Sbjct: 177 YFNPVGAHPSGDMGEDPQGIPNNLMP-YIAQVAVGRRDSLAIFGNDYPTEDGTGVRDYIH 235
Query: 217 VED----HVRAIEAVLLKGEAREIYNISAGEERTNLEVVRTILRIMDKDESLIEFVEDRP 272
V D HV A+E + K IYN+ AG + L+VV + K + F R
Sbjct: 236 VMDLADGHVVAMEKLANK-PGVHIYNLGAGVGNSVLDVVNAFSKACGKPVN-YHFAPRRE 293
Query: 273 GHDIRYSLDSWKIIRELKWRPKYRFEEGIKKTVEWYLENEWWWK 316
G Y D+ K REL WR + +T++ ++ W W+
Sbjct: 294 GDLPAYWADASKADRELNWR--------VTRTLDEMAQDTWHWQ 329
>pir||T45892 dTDP-glucose 4-6-dehydratase-like protein - Arabidopsis thaliana
>gi|6729503|emb|CAB67659.1| (AL132966) dTDP-glucose
4-6-dehydratase-like protein [Arabidopsis thaliana]
Length = 433
Score = 102 bits (252), Expect = 6e-21
Identities = 83/312 (26%), Positives = 142/312 (44%), Gaps = 21/312 (6%)
Query: 1 MRILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDV 60
+RI+VTGG GF+GS+ + ++ + + EVI +D G NL + +PR+ ++ DV
Sbjct: 120 LRIVVTGGAGFVGSHLVDKLIGRGD--EVIVIDNFFTG-RKENLVHLFSNPRFELIRHDV 176
Query: 61 ADFELVRELIKKVDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKENPGVRLV 120
V ++ +VD I H A + +P + +NV+GT +L ++ G R +
Sbjct: 177 -----VEPILLEVDQIYHLACPASPVHYKYNPVKTIKTNVMGTLNMLGLAKR--VGARFL 229
Query: 121 HISTDEVYGDILKGSFTEE-----DRLMPSSPYSATKAASDMLVLGWARTYGLNASITRC 175
ST EVYGD L+ E + + S Y K ++ L + + R G+ I R
Sbjct: 230 LTSTSEVYGDPLEHPQKETYWGNVNPIGERSCYDEGKRTAETLAMDYHRGAGVEVRIARI 289
Query: 176 TNNYGPYQFPE--KLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVEDHVRAIEAVLLKGEA 233
N YGP + +++ + + + +YG GK R + YV D L++ +
Sbjct: 290 FNTYGPRMCLDDGRVVSNFVAQTIRKHPMTVYGDGKQTRSFQYVSD---LGLVALMENDH 346
Query: 234 REIYNISAGEERTNLEVVRTILRIMDKDESLIEFVEDRPGHDIRYSLDSWKIIRELKWRP 293
+N+ E T LE+ + ++D + IEF + + D K +L W P
Sbjct: 347 VGPFNLGNPGEFTMLELAEVVKEVID-PSATIEFKPNTADDPHKRKPDISKAKEQLNWEP 405
Query: 294 KYRFEEGIKKTV 305
K EG+ + V
Sbjct: 406 KISLREGLPRMV 417
>sp|Q56093|GALE_SALTI UDP-GLUCOSE 4-EPIMERASE (GALACTOWALDENASE) (UDP-GALACTOSE
4-EPIMERASE) >gi|1073667|pir||S51328 UDPglucose
4-epimerase (EC 5.1.3.2) - Salmonella typhi
>gi|634103|emb|CAA58779.1| (X83927) UDP-galactose
4-epimerase [Salmonella typhi]
Length = 338
Score = 101 bits (250), Expect = 1e-20
Identities = 99/344 (28%), Positives = 159/344 (45%), Gaps = 43/344 (12%)
Query: 1 MRILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQ--DDPRYTFVKG 58
MR+LVTGG G+IGS+ +L+ +D V+ LD L S + L I+ TFV+G
Sbjct: 1 MRVLVTGGSGYIGSHTCVQLLQNGHD--VVILDNLC-NSKRSVLPVIERLGGKHPTFVEG 57
Query: 59 DVADFELVRELIKK--VDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKENPG 116
D+ + L+ E++ +D ++HFA V S++ P + +NV GT L+ A+R N
Sbjct: 58 DIRNEALITEILHDHAIDTVIHFAGLKAVGESVAKPLEYYDNNVNGTLRLVSAMRAANV- 116
Query: 117 VRLVHISTDEVYGDILKGSFTEE-DRLMPSSPYSATKAASDMLVLGWARTY-GLNASITR 174
L+ S+ VYGD K + E P SPY +K + ++ + + ++ R
Sbjct: 117 KNLIFSSSATVYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQPEWSIALLR 176
Query: 175 CTNNYG----------PYQFPEKLIPKTIIRAKMGLK--VPIYGT------GKNVRDWLY 216
N G P P L+P I + +G + + ++G G VRD+++
Sbjct: 177 YFNPVGAHPSGDMGEDPQGIPNNLMP-YIAQVAVGRRESLAVFGNDYPTEDGTGVRDYIH 235
Query: 217 VED----HVRAIEAVLLKGEAREIYNISAGEERTNLEVVRTILRIMDKDESLIEFVEDRP 272
V D HV A+E + K IYN+ AG + L+VV + K + F R
Sbjct: 236 VMDLADGHVVAMEKLADKSGV-HIYNLGAGVGSSVLDVVNAFSKACGKPIN-YHFAPRRD 293
Query: 273 GHDIRYSLDSWKIIRELKWRPKYRFEEGIKKTVEWYLENEWWWK 316
G Y D+ K REL WR + +T++ ++ W W+
Sbjct: 294 GDLPAYWADASKADRELNWR--------VTRTLDEMAQDTWHWQ 329
>pir||F81317 UDPglucose 4-epimerase (EC 5.1.3.2) Cj1131c [imported] -
Campylobacter jejuni (strain NCTC 11168)
>gi|6968565|emb|CAB73386.1| (AL139077) UDP-glucose
4-epimerase [Campylobacter jejuni]
Length = 328
Score = 101 bits (250), Expect = 1e-20
Identities = 92/335 (27%), Positives = 154/335 (45%), Gaps = 39/335 (11%)
Query: 1 MRILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDV 60
M+IL++GG G+IGS+ +R L+ D E+ LD L+ GS A ++D+Q + F + D+
Sbjct: 1 MKILISGGAGYIGSHTLRQFLK--TDHEICVLDNLSKGSKIA-IEDLQKTRAFKFFEQDL 57
Query: 61 ADFELVRELIK--KVDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKENPGVR 118
+DF+ V+ L + K DAIVHFAA V S+ +P + +N + T L+E + +
Sbjct: 58 SDFQGVKALFEREKFDAIVHFAASIEVFESMQNPLKYYMNNTVNTTNLIETCLQTGVN-K 116
Query: 119 LVHISTDEVYGDILKGSFTEEDRLMPSSPYSATKAASDMLVLGWARTYGLNASITRCTNN 178
+ ST YG+ +E L P +PY +K S+ ++ + N C
Sbjct: 117 FIFSSTAATYGEPQTPVVSETSPLAPINPYGRSKLMSEEVLRDASMA---NPEFKHCILR 173
Query: 179 Y-------GPYQFPEKLIPKTIIRAKMGL--------KVPIYG------TGKNVRDWLYV 217
Y Y ++ PK + K+ K+ I+G G +RD+++V
Sbjct: 174 YFNVAGACMDYTLGQR-YPKATLLIKVAAECAAGKRDKLFIFGDDYDTKDGTCIRDFIHV 232
Query: 218 ED----HVRAIEAVLLKGEAREIYNISAGEERTNLEVVRTILRIMDKDESLIEFVEDRPG 273
+D H+ A++ LK ++N+ G + EV+ + ++ D +E R G
Sbjct: 233 DDISSAHLAALD--YLKENESNVFNVGYGHGFSVKEVIEAMKKVSGVDFK-VELAPRRAG 289
Query: 274 HDIRYSLDSWKIIRELKWRPKYRFEEGI-KKTVEW 307
D+ KI W+PKY E I K +W
Sbjct: 290 DPSVLISDASKIRNLTSWQPKYDDLELICKSAFDW 324
>pir||G69142 GDP-D-mannose dehydratase - Methanobacterium thermoautotrophicum
(strain Delta H) >gi|2621389|gb|AAB84839.1| (AE000818)
GDP-D-mannose dehydratase [Methanobacterium
thermoautotrophicum]
Length = 348
Score = 101 bits (249), Expect = 1e-20
Identities = 91/322 (28%), Positives = 141/322 (43%), Gaps = 12/322 (3%)
Query: 4 LVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDVAD- 62
L+TG G G+ +++LEK +EV + + N L+ ++ R V D+ D
Sbjct: 5 LITGITGQDGAYLAKFLLEK--GYEVYGIYRRLSTPNFWRLQYLEIFDRINLVPADLTDE 62
Query: 63 FELVREL-IKKVDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKENPGVRLVH 121
F L+ L I D + H AA+S V S P + H + ++LEAIR NP +R
Sbjct: 63 FSLLESLKISDADEVYHLAAQSFVGTSFEQPTSTAHVTGVAVTSMLEAIRHYNPHIRFYQ 122
Query: 122 ISTDEVYGDILKGSFTEEDRLMPSSPYSATKAASDMLVLGWARTYGLNASITRCTNNYGP 181
S+ E+YGD E PSSPY+A K + + Y + A N+ P
Sbjct: 123 ASSSEIYGDGHTTILNENSPFKPSSPYAAAKLYGYWMTRIYREGYDIFACNGILFNHESP 182
Query: 182 ---YQFPEKLIPKTIIRAKMGLKVP-IYGTGKNVRDWLYVEDHVRAIEAVLLKGEAREIY 237
+F + I T + +GL+ + G RDW Y D+V A+ ++L+ + + +
Sbjct: 183 LRGLEFVTRKISNTAAKIALGLEDELLLGNLDAKRDWGYAPDYVEAMH-MMLQHKEPDDF 241
Query: 238 NISAGEERTNLEVVRTILRIMDKDESLIEFVEDR--PGHDIRYSLDSWKIIRE-LKWRPK 294
I+ E T E + D V+ R D+ Y + RE L W+PK
Sbjct: 242 VIATAETHTVREFCEKSFEELGLDWQDYVKVDKRFFRPLDVNYLCGDYSKARENLGWQPK 301
Query: 295 YRFEEGIKKTVEWYLENEWWWK 316
+FEE +K V LE W+
Sbjct: 302 TKFEELVKIMVREDLERWERWQ 323
>sp|P09147|GALE_ECOLI UDP-GLUCOSE 4-EPIMERASE (GALACTOWALDENASE) (UDP-GALACTOSE
4-EPIMERASE) >gi|68390|pir||XUECUG UDPglucose
4-epimerase (EC 5.1.3.2) - Escherichia coli
>gi|2914620|pdb|1UDC| Structure Of
Udp-Galactose-4-Epimerase Complexed With Udp-Mannose
>gi|2981901|pdb|2UDP|A Chain A, Udp-Galactose
4-Epimerase Complexed With Udp-Phenol
>gi|2981902|pdb|2UDP|B Chain B, Udp-Galactose
4-Epimerase Complexed With Udp-Phenol
>gi|41523|emb|CAA29573.1| (X06226)
UDP-galactose-4-epimerase [Escherichia coli]
>gi|1651344|dbj|BAA35421.1| (D90714) UDP-glucose
4-epimerase (EC 5.1.3.2) (galactowaldenase).
[Escherichia coli] >gi|1786974|gb|AAC73846.1| (AE000178)
UDP-galactose-4-epimerase [Escherichia coli K12]
Length = 338
Score = 101 bits (248), Expect = 2e-20
Identities = 100/344 (29%), Positives = 157/344 (45%), Gaps = 43/344 (12%)
Query: 1 MRILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQ--DDPRYTFVKG 58
MR+LVTGG G+IGS+ +L+ +D VI LD L S + L I+ TFV+G
Sbjct: 1 MRVLVTGGSGYIGSHTCVQLLQNGHD--VIILDNLC-NSKRSVLPVIERLGGKHPTFVEG 57
Query: 59 DVADFELVRELIKK--VDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKENPG 116
D+ + L+ E++ +D ++HFA V S+ P + +NV GT L+ A+R N
Sbjct: 58 DIRNEALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAANV- 116
Query: 117 VRLVHISTDEVYGDILKGSFTEE-DRLMPSSPYSATKAASDMLVLGWARTY-GLNASITR 174
+ S+ VYGD K + E P SPY +K + ++ + + ++ R
Sbjct: 117 KNFIFSSSATVYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQPDWSIALLR 176
Query: 175 CTNNYG----------PYQFPEKLIPKTIIRAKMGLK--VPIYGT------GKNVRDWLY 216
N G P P L+P I + +G + + I+G G VRD+++
Sbjct: 177 YFNPVGAHPSGDMGEDPQGIPNNLMP-YIAQVAVGRRDSLAIFGNDYPTEDGTGVRDYIH 235
Query: 217 VED----HVRAIEAVLLKGEAREIYNISAGEERTNLEVVRTILRIMDKDESLIEFVEDRP 272
V D HV A+E + K IYN+ AG + L+VV + K + F R
Sbjct: 236 VMDLADGHVVAMEKLANK-PGVHIYNLGAGVGNSVLDVVNAFSKACGKPVN-YHFAPRRE 293
Query: 273 GHDIRYSLDSWKIIRELKWRPKYRFEEGIKKTVEWYLENEWWWK 316
G Y D+ K REL WR + +T++ ++ W W+
Sbjct: 294 GDLPAYWADASKADRELNWR--------VTRTLDEMAQDTWHWQ 329
>pdb|1UDB| Structure Of Udp-Galactose-4-Epimerase Complexed With
Udp-4-Deoxy-4-Fluoro-Alpha-D-Glucose
>gi|2914618|pdb|1UDA| Structure Of
Udp-Galactose-4-Epimerase Complexed With
Udp-4-Deoxy-4-Fluoro-Alpha-D-Galactose
>gi|1942804|pdb|1NAH| Udp-Galactose 4-Epimerase From
Escherichia Coli, Reduced >gi|1942240|pdb|1XEL|
Udp-Galactose 4-Epimerase From Escherichia Coli
>gi|1942805|pdb|1NAI| Udp-Galactose 4-Epimerase From
Escherichia Coli, Oxidized
Length = 338
Score = 101 bits (248), Expect = 2e-20
Identities = 100/344 (29%), Positives = 157/344 (45%), Gaps = 43/344 (12%)
Query: 1 MRILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQ--DDPRYTFVKG 58
MR+LVTGG G+IGS+ +L+ +D VI LD L S + L I+ TFV+G
Sbjct: 1 MRVLVTGGSGYIGSHTCVQLLQNGHD--VIILDNLC-NSKRSVLPVIERLGGKHPTFVEG 57
Query: 59 DVADFELVRELIKK--VDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKENPG 116
D+ + L+ E++ +D ++HFA V S+ P + +NV GT L+ A+R N
Sbjct: 58 DIRNEALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAANV- 116
Query: 117 VRLVHISTDEVYGDILKGSFTEE-DRLMPSSPYSATKAASDMLVLGWARTY-GLNASITR 174
+ S+ VYGD K + E P SPY +K + ++ + + ++ R
Sbjct: 117 KNFIFSSSATVYGDNPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQPDWSIALLR 176
Query: 175 CTNNYG----------PYQFPEKLIPKTIIRAKMGLK--VPIYGT------GKNVRDWLY 216
N G P P L+P I + +G + + I+G G VRD+++
Sbjct: 177 YFNPVGAHPSGDMGEDPQGIPNNLMP-YIAQVAVGRRDSLAIFGNDYPTEDGTGVRDYIH 235
Query: 217 VED----HVRAIEAVLLKGEAREIYNISAGEERTNLEVVRTILRIMDKDESLIEFVEDRP 272
V D HV A+E + K IYN+ AG + L+VV + K + F R
Sbjct: 236 VMDLADGHVVAMEKLANK-PGVHIYNLGAGVGNSVLDVVNAFSKACGKPVN-YHFAPRRE 293
Query: 273 GHDIRYSLDSWKIIRELKWRPKYRFEEGIKKTVEWYLENEWWWK 316
G Y D+ K REL WR + +T++ ++ W W+
Sbjct: 294 GDLPAYWADASKADRELNWR--------VTRTLDEMAQDTWHWQ 329
>pdb|1KVR| Udp-Galactose 4-Epimerase Complexed With Udp-Phenol
Length = 338
Score = 100 bits (247), Expect = 2e-20
Identities = 100/344 (29%), Positives = 156/344 (45%), Gaps = 43/344 (12%)
Query: 1 MRILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQ--DDPRYTFVKG 58
MR+LVTGG G+IGS+ +L+ +D VI LD L S + L I+ TFV+G
Sbjct: 1 MRVLVTGGSGYIGSHTCVQLLQNGHD--VIILDNLC-NSKRSVLPVIERLGGKHPTFVEG 57
Query: 59 DVADFELVRELIKK--VDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKENPG 116
D+ + L+ E++ +D ++HFA V S+ P + +NV GT L+ A+R N
Sbjct: 58 DIRNEALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAANV- 116
Query: 117 VRLVHISTDEVYGDILKGSFTEE-DRLMPSSPYSATKAASDMLVLGWARTY-GLNASITR 174
+ S VYGD K + E P SPY +K + ++ + + ++ R
Sbjct: 117 KNFIFSSAATVYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQPDWSIALLR 176
Query: 175 CTNNYG----------PYQFPEKLIPKTIIRAKMGLK--VPIYGT------GKNVRDWLY 216
N G P P L+P I + +G + + I+G G VRD+++
Sbjct: 177 YFNPVGAHPSGDMGEDPQGIPNNLMP-YIAQVAVGRRDSLAIFGNDYPTEDGTGVRDYIH 235
Query: 217 VED----HVRAIEAVLLKGEAREIYNISAGEERTNLEVVRTILRIMDKDESLIEFVEDRP 272
V D HV A+E + K IYN+ AG + L+VV + K + F R
Sbjct: 236 VMDLADGHVVAMEKLANK-PGVHIYNLGAGVGNSVLDVVNAFSKACGKPVN-YHFAPRRE 293
Query: 273 GHDIRYSLDSWKIIRELKWRPKYRFEEGIKKTVEWYLENEWWWK 316
G Y D+ K REL WR + +T++ ++ W W+
Sbjct: 294 GDLPAYWADASKADRELNWR--------VTRTLDEMAQDTWHWQ 329
>pdb|1KVT| Udp-Galactose 4-Epimerase Complexed With Udp-Phenol
Length = 338
Score = 100 bits (247), Expect = 2e-20
Identities = 100/344 (29%), Positives = 156/344 (45%), Gaps = 43/344 (12%)
Query: 1 MRILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQ--DDPRYTFVKG 58
MR+LVTGG G+IGS+ +L+ +D VI LD L S + L I+ TFV+G
Sbjct: 1 MRVLVTGGSGYIGSHTCVQLLQNGHD--VIILDNLC-NSKRSVLPVIERLGGKHPTFVEG 57
Query: 59 DVADFELVRELIKK--VDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKENPG 116
D+ + L+ E++ +D ++HFA V S+ P + +NV GT L+ A+R N
Sbjct: 58 DIRNEALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAANV- 116
Query: 117 VRLVHISTDEVYGDILKGSFTEE-DRLMPSSPYSATKAASDMLVLGWARTY-GLNASITR 174
+ S VYGD K + E P SPY +K + ++ + + ++ R
Sbjct: 117 KNFIFSSVATVYGDNPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQPDWSIALLR 176
Query: 175 CTNNYG----------PYQFPEKLIPKTIIRAKMGLK--VPIYGT------GKNVRDWLY 216
N G P P L+P I + +G + + I+G G VRD+++
Sbjct: 177 YFNPVGAHPSGDMGEDPQGIPNNLMP-YIAQVAVGRRDSLAIFGNDYPTEDGTGVRDYIH 235
Query: 217 VED----HVRAIEAVLLKGEAREIYNISAGEERTNLEVVRTILRIMDKDESLIEFVEDRP 272
V D HV A+E + K IYN+ AG + L+VV + K + F R
Sbjct: 236 VMDLADGHVVAMEKLANK-PGVHIYNLGAGVGNSVLDVVNAFSKACGKPVN-YHFAPRRE 293
Query: 273 GHDIRYSLDSWKIIRELKWRPKYRFEEGIKKTVEWYLENEWWWK 316
G Y D+ K REL WR + +T++ ++ W W+
Sbjct: 294 GDLPAYWADASKADRELNWR--------VTRTLDEMAQDTWHWQ 329
>pdb|1KVQ| Udp-Galactose 4-Epimerase Complexed With Udp-Phenol
Length = 338
Score = 100 bits (247), Expect = 2e-20
Identities = 100/344 (29%), Positives = 156/344 (45%), Gaps = 43/344 (12%)
Query: 1 MRILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQ--DDPRYTFVKG 58
MR+LVTGG G+IGS+ +L+ +D VI LD L S + L I+ TFV+G
Sbjct: 1 MRVLVTGGSGYIGSHTCVQLLQNGHD--VIILDNLC-NSKRSVLPVIERLGGKHPTFVEG 57
Query: 59 DVADFELVRELIKK--VDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKENPG 116
D+ + L+ E++ +D ++HFA V S+ P + +NV GT L+ A+R N
Sbjct: 58 DIRNEALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAANV- 116
Query: 117 VRLVHISTDEVYGDILKGSFTEE-DRLMPSSPYSATKAASDMLVLGWARTY-GLNASITR 174
+ S VYGD K + E P SPY +K + ++ + + ++ R
Sbjct: 117 KNFIFSSAATVYGDNPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQPDWSIALLR 176
Query: 175 CTNNYG----------PYQFPEKLIPKTIIRAKMGLK--VPIYGT------GKNVRDWLY 216
N G P P L+P I + +G + + I+G G VRD+++
Sbjct: 177 YFNPVGAHPSGDMGEDPQGIPNNLMP-YIAQVAVGRRDSLAIFGNDYPTEDGTGVRDYIH 235
Query: 217 VED----HVRAIEAVLLKGEAREIYNISAGEERTNLEVVRTILRIMDKDESLIEFVEDRP 272
V D HV A+E + K IYN+ AG + L+VV + K + F R
Sbjct: 236 VMDLADGHVVAMEKLANK-PGVHIYNLGAGVGNSVLDVVNAFSKACGKPVN-YHFAPRRE 293
Query: 273 GHDIRYSLDSWKIIRELKWRPKYRFEEGIKKTVEWYLENEWWWK 316
G Y D+ K REL WR + +T++ ++ W W+
Sbjct: 294 GDLPAYWADASKADRELNWR--------VTRTLDEMAQDTWHWQ 329
>pdb|1KVU| Udp-Galactose 4-Epimerase Complexed With Udp-Phenol
Length = 338
Score = 99.5 bits (244), Expect = 5e-20
Identities = 99/344 (28%), Positives = 157/344 (44%), Gaps = 43/344 (12%)
Query: 1 MRILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQ--DDPRYTFVKG 58
MR+LVTGG G+IGS+ +L+ +D VI LD L S + L I+ TFV+G
Sbjct: 1 MRVLVTGGSGYIGSHTCVQLLQNGHD--VIILDNLC-NSKRSVLPVIERLGGKHPTFVEG 57
Query: 59 DVADFELVRELIKK--VDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKENPG 116
D+ + L+ E++ +D ++HFA V S+ P + +NV GT L+ A+R N
Sbjct: 58 DIRNEALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAANV- 116
Query: 117 VRLVHISTDEVYGDILKGSFTEE-DRLMPSSPYSATKAASDMLVLGWARTY-GLNASITR 174
+ S+ VYGD K + E P SP+ +K + ++ + + ++ R
Sbjct: 117 KNFIFSSSATVYGDQPKIPYVESFPTGTPQSPFGKSKLMVEQILTDLQKAQPDWSIALLR 176
Query: 175 CTNNYG----------PYQFPEKLIPKTIIRAKMGLK--VPIYGT------GKNVRDWLY 216
N G P P L+P I + +G + + I+G G VRD+++
Sbjct: 177 YFNPVGAHPSGDMGEDPQGIPNNLMP-YIAQVAVGRRDSLAIFGNDYPTEDGTGVRDYIH 235
Query: 217 VED----HVRAIEAVLLKGEAREIYNISAGEERTNLEVVRTILRIMDKDESLIEFVEDRP 272
V D HV A+E + K IYN+ AG + L+VV + K + F R
Sbjct: 236 VMDLADGHVVAMEKLANK-PGVHIYNLGAGVGNSVLDVVNAFSKACGKPVN-YHFAPRRE 293
Query: 273 GHDIRYSLDSWKIIRELKWRPKYRFEEGIKKTVEWYLENEWWWK 316
G Y D+ K REL WR + +T++ ++ W W+
Sbjct: 294 GDLPAYWADASKADRELNWR--------VTRTLDEMAQDTWHWQ 329
>pdb|1A9Y| Udp-Galactose 4-Epimerase Mutant S124aY149F COMPLEXED WITH
Udp-Glucose
Length = 338
Score = 99.1 bits (243), Expect = 7e-20
Identities = 99/344 (28%), Positives = 156/344 (44%), Gaps = 43/344 (12%)
Query: 1 MRILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQ--DDPRYTFVKG 58
MR+LVTGG G+IGS+ +L+ +D VI LD L S + L I+ TFV+G
Sbjct: 1 MRVLVTGGSGYIGSHTCVQLLQNGHD--VIILDNLC-NSKRSVLPVIERLGGKHPTFVEG 57
Query: 59 DVADFELVRELIKK--VDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKENPG 116
D+ + L+ E++ +D ++HFA V S+ P + +NV GT L+ A+R N
Sbjct: 58 DIRNEALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAANV- 116
Query: 117 VRLVHISTDEVYGDILKGSFTEE-DRLMPSSPYSATKAASDMLVLGWARTY-GLNASITR 174
+ S VYGD K + E P SP+ +K + ++ + + ++ R
Sbjct: 117 KNFIFSSAATVYGDQPKIPYVESFPTGTPQSPFGKSKLMVEQILTDLQKAQPDWSIALLR 176
Query: 175 CTNNYG----------PYQFPEKLIPKTIIRAKMGLK--VPIYGT------GKNVRDWLY 216
N G P P L+P I + +G + + I+G G VRD+++
Sbjct: 177 YFNPVGAHPSGDMGEDPQGIPNNLMP-YIAQVAVGRRDSLAIFGNDYPTEDGTGVRDYIH 235
Query: 217 VED----HVRAIEAVLLKGEAREIYNISAGEERTNLEVVRTILRIMDKDESLIEFVEDRP 272
V D HV A+E + K IYN+ AG + L+VV + K + F R
Sbjct: 236 VMDLADGHVVAMEKLANK-PGVHIYNLGAGVGNSVLDVVNAFSKACGKPVN-YHFAPRRE 293
Query: 273 GHDIRYSLDSWKIIRELKWRPKYRFEEGIKKTVEWYLENEWWWK 316
G Y D+ K REL WR + +T++ ++ W W+
Sbjct: 294 GDLPAYWADASKADRELNWR--------VTRTLDEMAQDTWHWQ 329
>pdb|1A9Z| Udp-Galactose 4-Epimerase Mutant S124aY149F COMPLEXED WITH
Udp-Galactose
Length = 338
Score = 99.1 bits (243), Expect = 7e-20
Identities = 99/344 (28%), Positives = 156/344 (44%), Gaps = 43/344 (12%)
Query: 1 MRILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQ--DDPRYTFVKG 58
MR+LVTGG G+IGS+ +L+ +D VI LD L S + L I+ TFV+G
Sbjct: 1 MRVLVTGGSGYIGSHTCVQLLQNGHD--VIILDNLC-NSKRSVLPVIERLGGKHPTFVEG 57
Query: 59 DVADFELVRELIKK--VDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKENPG 116
D+ + L+ E++ +D ++HFA V S+ P + +NV GT L+ A+R N
Sbjct: 58 DIRNEALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAANV- 116
Query: 117 VRLVHISTDEVYGDILKGSFTEE-DRLMPSSPYSATKAASDMLVLGWARTY-GLNASITR 174
+ S VYGD K + E P SP+ +K + ++ + + ++ R
Sbjct: 117 KNFIFSSAATVYGDNPKIPYVESFPTGTPQSPFGKSKLMVEQILTDLQKAQPDWSIALLR 176
Query: 175 CTNNYG----------PYQFPEKLIPKTIIRAKMGLK--VPIYGT------GKNVRDWLY 216
N G P P L+P I + +G + + I+G G VRD+++
Sbjct: 177 YFNPVGAHPSGDMGEDPQGIPNNLMP-YIAQVAVGRRDSLAIFGNDYPTEDGTGVRDYIH 235
Query: 217 VED----HVRAIEAVLLKGEAREIYNISAGEERTNLEVVRTILRIMDKDESLIEFVEDRP 272
V D HV A+E + K IYN+ AG + L+VV + K + F R
Sbjct: 236 VMDLADGHVVAMEKLANK-PGVHIYNLGAGVGNSVLDVVNAFSKACGKPVN-YHFAPRRE 293
Query: 273 GHDIRYSLDSWKIIRELKWRPKYRFEEGIKKTVEWYLENEWWWK 316
G Y D+ K REL WR + +T++ ++ W W+
Sbjct: 294 GDLPAYWADASKADRELNWR--------VTRTLDEMAQDTWHWQ 329
>pir||S75089 UDP-glucose 4-epimerase - Synechocystis sp. (strain PCC 6803)
>gi|1653034|dbj|BAA17951.1| (D90910) UDP-glucose
4-epimerase [Synechocystis sp.]
Length = 338
Score = 97.5 bits (239), Expect = 2e-19
Identities = 94/336 (27%), Positives = 154/336 (44%), Gaps = 41/336 (12%)
Query: 3 ILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDVAD 62
ILVTGG G+IGS+ + + + ++V+ D L+YG K++ V G D
Sbjct: 7 ILVTGGAGYIGSHGVLALQQA--GFDVLIYDNLSYGH-----KELVQPLGVELVVGHTGD 59
Query: 63 FELVRELI--KKVDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKENPGV-RL 119
+ + +L + + A++HFAA V S+ PD + +NV+GT TLLEA+ G+ +
Sbjct: 60 RQKLDQLFATRNIAAVMHFAAFIAVGESVQKPDIYYQNNVVGTLTLLEAMLA--AGIKKF 117
Query: 120 VHISTDEVYGDILKGSFTEEDRLMPSSPYSATKAASDMLVLGWARTYGLNASITRCTN-- 177
V ST VYG + TE + P SPY+A+K + ++ + + YG + I R N
Sbjct: 118 VFSSTCAVYGMPKEIPMTESHPIDPLSPYAASKRMVEQILADFDQAYGFKSVIFRYFNAS 177
Query: 178 ------NYGPYQFPE-KLIPKTIIRA-KMGLKVPIYGT------GKNVRDWLYVED---- 219
G PE LIP ++ A K ++ ++GT G +RD+++V D
Sbjct: 178 GADPQGRLGEDHNPETHLIPLALLTALKQRPQLSVFGTDYDTLDGTALRDYIHVCDLAIA 237
Query: 220 HVRAIEAVLLKGEAREIYNISAGEERTNLEVVRTILRIMDKDESLIEFVEDRPGHDIRYS 279
HV ++ LL+G I+N+ G + +V+ + D + RPG
Sbjct: 238 HVLGLQ-YLLEGGESNIFNLGNGNGFSVRQVIEVAKAVTGLDIP-YQLCPRRPGDAPILV 295
Query: 280 LDSWKIIRELKWRPKYRFEEGIKKTVEWYLENEWWW 315
S K L W P+Y + +++ W W
Sbjct: 296 GSSAKAREILGWNPQY-------PDLHTIIDHAWQW 324
>sp|P21977|GALE_STRTR UDP-GLUCOSE 4-EPIMERASE (GALACTOWALDENASE) (UDP-GALACTOSE
4-EPIMERASE) >gi|280223|pir||A44509 UDPglucose
4-epimerase (EC 5.1.3.2) - Streptococcus thermophilus
>gi|153749|gb|AAA26944.1| (M38175) UDPglucose
4-epimerase [Streptococcus thermophilus]
Length = 332
Score = 97.1 bits (238), Expect = 3e-19
Identities = 92/338 (27%), Positives = 153/338 (45%), Gaps = 41/338 (12%)
Query: 1 MRILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDV 60
M ILV GG G+IGS+ + ++EK + +V+ +D L G A P F +GD+
Sbjct: 1 MAILVLGGAGYIGSHMVDRLVEKGQE-KVVVVDSLVTGHRAAV------HPDAIFYQGDL 53
Query: 61 ADFELVRELIKK---VDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKENPGV 117
+D + +R++ K+ VDA++HFAA S V S+ P + +N G LLE + + GV
Sbjct: 54 SDQDFMRKVFKENPDVDAVIHFAAYSLVGESMEKPLKYFDNNTAGMVKLLEVMNE--CGV 111
Query: 118 R-LVHISTDEVYGDILKGSFTEEDRLMPSSPYSATKAASDMLVLGWARTYGLNASITRCT 176
+ +V ST YG + E P +PY +K + ++ + YG+ R
Sbjct: 112 KYIVFSSTAATYGIPEEIPILETTPQNPINPYGESKLMMETIMKWSDQAYGIKYVPLRYF 171
Query: 177 NNYGPYQF-------PEKLIPKTIIRAKMGL--KVPIYG------TGKNVRDWLYVED-- 219
N G E + I++ G+ K+ I+G G NVRD+++ D
Sbjct: 172 NVAGANLMVRLVRTRSETHLLPIILQVAQGVREKIMIFGDDYNTPDGTNVRDYVHPFDLA 231
Query: 220 --HVRAIEAVLLKGEAREIYNISAGEERTNLEVVRTILRIMDKDESLIEFVEDRPGHDIR 277
H+ A+E L KG +N+ + +NL+++ ++ K E E + RPG
Sbjct: 232 DAHLLAVE-YLRKGNESTAFNLGSSTGFSNLQILEAARKVTGK-EIPAEKADRRPGDPDI 289
Query: 278 YSLDSWKIIRELKWRPKYRFEEGIKKTVEWYLENEWWW 315
S K L W+P++ +E + + W W
Sbjct: 290 LIASSEKARTVLGWKPQF-------DNIEKIIASAWAW 320
>sp|P22715|GALE_SALTY UDP-GLUCOSE 4-EPIMERASE (GALACTOWALDENASE) (UDP-GALACTOSE
4-EPIMERASE) >gi|96866|pir||A37760 UDPglucose
4-epimerase (EC 5.1.3.2) - Salmonella typhimurium
>gi|154047|gb|AAA27111.1| (M33681) uridine
diphosphogalactose 4-epimerase (galE) (EC 5.1.3.2)
[Salmonella typhimurium]
Length = 337
Score = 94.8 bits (232), Expect = 1e-18
Identities = 97/344 (28%), Positives = 157/344 (45%), Gaps = 44/344 (12%)
Query: 1 MRILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQ--DDPRYTFVKG 58
MR+LVTGG G+IGS+ +L+ +D V+ LD L S + L I+ TFV+G
Sbjct: 1 MRVLVTGGSGYIGSHTCVQLLQNGHD--VVILDNLC-NSKRSVLPVIERLGGKHPTFVEG 57
Query: 59 DVADFELVRELIKK--VDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKENPG 116
D+ + L+ E++ +D ++HFA V S++ P + +NV GT L+ A+R N
Sbjct: 58 DIRNEALITEILHDHAIDTVIHFAGLKAVGNSVARPLEYYDNNVNGTLRLVSAMRAANV- 116
Query: 117 VRLVHISTDEVYGDILKGSFTEE-DRLMPSSPYSATKAASDMLVLGWARTY-GLNASITR 174
L+ S+ VYGD K + E P SP +K + ++ + + ++ R
Sbjct: 117 KNLIFSSSATVYGDQPKIPYVESFPTGAPQSPTGKSKLMVEQILTDLQKAQPEWSIALLR 176
Query: 175 CTNNYG----------PYQFPEKLIPKTIIRAKMGLK--VPIYGT------GKNVRDWLY 216
N G P P L+P I + +G + + ++G G VRD+++
Sbjct: 177 YFNPVGAHPSGDMGEDPQGIPNNLMP-YIAQVAVGRRESLAVFGNDYPTEDGTGVRDYIH 235
Query: 217 VED----HVRAIEAVLLKGEAREIYNISAGEERTNLEVVRTILRIMDKDESLIEFVEDRP 272
V D HV A+E + K IYN+ AG + L+VV + K + R
Sbjct: 236 VMDLADGHVVAMEKLADKSGV-HIYNLGAGVGSSVLDVVNAFSKACGK--PINYHFAPRD 292
Query: 273 GHDIRYSLDSWKIIRELKWRPKYRFEEGIKKTVEWYLENEWWWK 316
G Y D+ K REL WR + +T++ ++ W W+
Sbjct: 293 GDLPAYWADASKADRELNWR--------VTRTLDEMAQDTWHWQ 328
>gb|AAF25549.1|AF109295_4 (AF109295) GalE [Staphylococcus carnosus]
Length = 329
Score = 93.6 bits (229), Expect = 3e-18
Identities = 87/337 (25%), Positives = 151/337 (43%), Gaps = 40/337 (11%)
Query: 1 MRILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDV 60
M +LV GG G+IGS+ ++E+ D V+ D L G A + + R F +GD+
Sbjct: 1 MSVLVLGGAGYIGSHAADQLIEQGYDVAVV--DNLGTGHRQA----VPETAR--FYEGDI 52
Query: 61 ADFELVRELIKK--VDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKENPGVR 118
D + + ++ V+ + HF A S V S+ P + ++NV G LLE ++ +
Sbjct: 53 RDKAFLNHVFEQENVEGVFHFCAYSLVGESVEKPLEYFNNNVYGMQVLLEVMKAHDVN-E 111
Query: 119 LVHISTDEVYGDILKGSFTEEDRLMPSSPYSATKAASDMLVLGWARTYGLNASITRCTN- 177
++ ST VYG+ E+ P++PY +K + ++ YG+N + R N
Sbjct: 112 IIFSSTAAVYGEPEIIPIQEDAPKAPTNPYGESKLMMEKMMHWCHNAYGVNYAALRYFNV 171
Query: 178 -------NYGPYQFPEKLIPKTIIRAKMGLK--VPIYGT------GKNVRDWLYVED--- 219
+ G PE + +++A +G + + I+GT G VRD+L+V D
Sbjct: 172 AGAKEDGSIGEDHNPETHLIPIVLQAALGQRDAITIFGTDYDTEDGSCVRDYLHVTDLIA 231
Query: 220 -HVRAIEAVLLKGEAREIYNISAGEERTNLEVVRTILRIMDKDESLIEFVEDRPGHDIRY 278
H+ A + + GE+ +N+ + + + +E+V + D E E R G +
Sbjct: 232 AHILAYQYLKDGGES-GAFNLGSSQGYSVIEIVEAARKATGIDIK-AEIGERRAGDPSKL 289
Query: 279 SLDSWKIIRELKWRPKYRFEEGIKKTVEWYLENEWWW 315
S K R L W+PK+ + +E W W
Sbjct: 290 VASSDKAQRVLGWKPKH-------DDIHEIIETAWNW 319
>gi|6319493 UDP-glucose 4-epimerase; Gal10p [Saccharomyces cerevisiae]
>gi|585169|sp|P04397|GALX_YEAST GAL10 BIFUNCTIONAL
PROTEIN [INCLUDES: UDP-GLUCOSE 4-EPIMERASE
(GALACTOWALDENASE); ALDOSE 1-EPIMERASE (MUTAROTASE)]
>gi|625246|pir||XEBYUG UDPglucose 4-epimerase (EC
5.1.3.2) - yeast (Saccharomyces cerevisiae)
>gi|536222|emb|CAA84961.1| (Z35888) ORF YBR019c
[Saccharomyces cerevisiae]
Length = 699
Score = 92.1 bits (225), Expect = 9e-18
Identities = 93/349 (26%), Positives = 160/349 (45%), Gaps = 41/349 (11%)
Query: 3 ILVTGGMGFIGSNFIRYILEKHNDWEVI-NLDKLTYGSNPANLKDIQDDPRYTFVKGDVA 61
+LVTGG G+IGS+ + ++E D V NL TY S A L ++ F + D+
Sbjct: 14 VLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDS-VARL-EVLTKHHIPFYEVDLC 71
Query: 62 DFELVRELIK--KVDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKENPGVRL 119
D + + ++ K K+D+++HFA V S P + H+N++GT LLE +++ N +
Sbjct: 72 DRKGLEKVFKEYKIDSVIHFAGLKAVGESTQIPLRYYHNNILGTVVLLELMQQYNVS-KF 130
Query: 120 VHISTDEVYGDILKG----SFTEEDRLMPSSPYSATKAASDMLV--LGWARTYGLNASIT 173
V S+ VYGD + EE L P++PY TK A + ++ L + +I
Sbjct: 131 VFSSSATVYGDATRFPNMIPIPEECPLGPTNPYGHTKYAIENILNDLYNSDKKSWKFAIL 190
Query: 174 RCTNNYG----------PYQFPEKLIPKTIIRAKMGLKVPIY--------GTGKNVRDWL 215
R N G P P L+P + + +G + +Y G +RD++
Sbjct: 191 RYFNPIGAHPSGLIGEDPLGIPNNLLP-YMAQVAVGRREKLYIFGDDYDSRDGTPIRDYI 249
Query: 216 YVED----HVRAIEAVLL----KGEAREIYNISAGEERTNLEVVRTILRIMDKDESLIEF 267
+V D H+ A++ + +G RE +N+ +G+ T EV + D +
Sbjct: 250 HVVDLAKGHIAALQYLEAYNENEGLCRE-WNLGSGKGSTVFEVYHAFCKASGIDLP-YKV 307
Query: 268 VEDRPGHDIRYSLDSWKIIRELKWRPKYRFEEGIKKTVEWYLENEWWWK 316
R G + + + RELKW+ + + E+ K +W EN + ++
Sbjct: 308 TGRRAGDVLNLTAKPDRAKRELKWQTELQVEDSCKDLWKWTTENPFGYQ 356
>sp|P96995|GALE_STRMU UDP-GLUCOSE 4-EPIMERASE (GALACTOWALDENASE) (UDP-GALACTOSE
4-EPIMERASE) >gi|7437233|pir||JC5313 UDPglucose
4-epimerase (EC 5.1.3.2) - Streptococcus mutans
>gi|1877424|gb|AAB49738.1| (U21942) UDP-galactose
4-epimerase [Streptococcus mutans]
Length = 333
Score = 91.7 bits (224), Expect = 1e-17
Identities = 88/339 (25%), Positives = 151/339 (43%), Gaps = 42/339 (12%)
Query: 1 MRILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDV 60
M ILV GG G+IGS+ + ++EK + EV+ +D L G A P F +GD+
Sbjct: 1 MAILVLGGAGYIGSHMVDRLIEKGEE-EVVVVDSLVTGHRAAV------HPAAKFYQGDL 53
Query: 61 ADFELVRELIKK---VDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKENPGV 117
AD E + + ++ VDA++HFAA S V S+ P + +N G LLE + + GV
Sbjct: 54 ADREFMSMVFRENPDVDAVIHFAAYSLVAESMKKPLKYFDNNTAGMIKLLEVMSEF--GV 111
Query: 118 R-LVHISTDEVYGDILKGSFTEEDRLMPSSPYSATKAASDMLVLGWARTYGL-------- 168
+ +V ST YG + E P +PY +K + ++ R YG+
Sbjct: 112 KYIVFSSTAATYGIPNEIPIKETTPQRPINPYGESKLMMETIMKWSDRAYGIKFVPVRYF 171
Query: 169 NASITRCTNNYGPYQFPEKLIPKTIIRAKMGL--KVPIYG------TGKNVRDWLYVED- 219
N + + + G PE + I++ G+ K+ I+G G NVRD+++ D
Sbjct: 172 NVAGAKPDGSIGEDHSPETHLLPIILQVAQGVREKIMIFGDDYNTPDGTNVRDYVHPFDL 231
Query: 220 ---HVRAIEAVLLKGEAREIYNISAGEERTNLEVVRTILRIMDKDESLIEFVEDRPGHDI 276
H+ A+ L +G +N+ + +NL+++ ++ + + E R G
Sbjct: 232 ADRHLLALN-YLRQGNPSTAFNLGSSTGFSNLQILEAARKVTGQ-KIPAEKAARRSGDPD 289
Query: 277 RYSLDSWKIIRELKWRPKYRFEEGIKKTVEWYLENEWWW 315
S K + W+P++ +E + + W W
Sbjct: 290 TLIASSEKAREVVGWKPQF-------DDIEKIIASAWAW 321
>gb|AAD25749.1|AC007060_7 (AC007060) Strong similarity to F19I3.8 gi|3033381 putative
UDP-galactose-4-epimerase from Arabidopsis thaliana BAC
gb|AC004238 and is a member of PF|01370 the NAD
dependent epimerase/dehydratase family. EST gb|AA597338
comes from this gene
Length = 419
Score = 91.3 bits (223), Expect = 1e-17
Identities = 95/344 (27%), Positives = 156/344 (44%), Gaps = 40/344 (11%)
Query: 3 ILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPAN--LKDIQDDP-RYTFVKGD 59
+LVTGG G+IGS+ +L++ + V +D L+ G+ A L+++ +P R F+ D
Sbjct: 73 VLVTGGAGYIGSHAALRLLKE--SYRVTIVDNLSRGNLAAVRILQELFPEPGRLQFIYAD 130
Query: 60 VADFELVRELIKK--VDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKENPGV 117
+ D + V ++ + DA++HFAA ++V S P + H+ T +LE + GV
Sbjct: 131 LGDAKAVNKIFTENAFDAVMHFAAVAYVGESTQFPLKYYHNITSNTLVVLETMAAH--GV 188
Query: 118 R-LVHISTDEVYGDILKGSFTEEDRLMPSSPYSATKAASDMLVLGWARTYGLNASITRCT 176
+ L++ ST YG+ TEE +P +PY K ++ ++L +++ + I R
Sbjct: 189 KTLIYSSTCATYGEPDIMPITEETPQVPINPYGKAKKMAEDIILDFSKNSDMAVMILRYF 248
Query: 177 NNYG------------PYQFPEKLIPKTIIRAKMGLK--VPIYGT------GKNVRDWLY 216
N G P I A G+ + I GT G VRD++
Sbjct: 249 NVIGSDPEGRLGEAPRPELREHGRISGACFDAARGIMPGLQIKGTDYKTADGTCVRDYID 308
Query: 217 VEDHVRAIEAVLLKGEARE--IYNISAGEERTNLEVVRTILRIMDKDESLIEFVEDRPGH 274
V D V A L K + R+ IYN+ G+ + E V + E I+++ R G
Sbjct: 309 VTDLVDAHVKALQKAKPRKVGIYNVGTGKGSSVKEFVEACKKATGV-EIKIDYLPRRAGD 367
Query: 275 DIRYSLDSWKIIRELKWRPKYRFEEGIKKTVEWYLENEWWWKPL 318
D KI +EL W K+ +K++ LE W W+ L
Sbjct: 368 YAEVYSDPSKIRKELNWTAKH---TNLKES----LETAWRWQKL 404
>gb|AAA57872.1| (U09349) UDP-glucose 4-epimerase [Azospirillum brasilense]
Length = 338
Score = 90.9 bits (222), Expect = 2e-17
Identities = 94/334 (28%), Positives = 146/334 (43%), Gaps = 39/334 (11%)
Query: 3 ILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDVAD 62
+LVTGG G++GS+ + +L++ + V+ LD L G A D FV+ D+AD
Sbjct: 7 VLVTGGAGYVGSHCVAELLDR--GFRVVVLDNLRQGHRVAVPSDA------AFVEADLAD 58
Query: 63 FELVRELIK--KVDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKENPGVR-L 119
+ + + + DA+ HFAA S V S+ P +LH N + + L+ A GVR +
Sbjct: 59 MDALTRVFAEWRFDAVFHFAALSLVGESMRDPHLYLHGNTVNSLNLIRA--ATTAGVRKM 116
Query: 120 VHISTDEVYGDILKGSFTEEDRLMPSSPYSATKAASDMLVLGWA-RTYGLNASITRCTNN 178
V ST ++G + EE + P SPY +K + L WA R +GL ++ R N
Sbjct: 117 VFSSTANLFGTPERLPIDEETTIDPGSPYGESKFFIER-ALHWADRCHGLRSACLRYFNA 175
Query: 179 YGPY--------QFPE-KLIPKTIIRAKMGLK-VPIYG------TGKNVRDWLYVEDHVR 222
G + PE LIP + G + I+G G VRD+++V D
Sbjct: 176 AGAHPNGTLGEDHAPETHLIPLVLDAPAAGRSHIEIFGDDYPTADGTCVRDYIHVCDLAD 235
Query: 223 AIEAVLLKGEAREIYNISAGEERTNLEVVRTILRIMDKDESLIEFVEDRPGHDIRYSLDS 282
A VL E R +N+ G + EV+ R+ + R G S
Sbjct: 236 AHLRVLPALETRSRFNLGNGTGYSVREVIAATERVTGLTVP-VRVGPRRAGDPAVLIASS 294
Query: 283 WKIIRELKWRPKYRFEEGIKKTVEWYLENEWWWK 316
+I EL W P++ + I + + W W+
Sbjct: 295 ERIRGELGWSPRFPDLDSI-------IGSAWEWR 321
>sp|Q9T0A7|GAE3_ARATH PROBABLE UDP-GLUCOSE 4-EPIMERASE (GALACTOWALDENASE) (UDP-GALACTOSE
4-EPIMERASE) >gi|7437229|pir||T08911 UDPglucose
4-epimerase (EC 5.1.3.2) T32A16.90 - Arabidopsis
thaliana >gi|4972096|emb|CAB43892.1| (AL078468)
UDPglucose 4-epimerase-like protein [Arabidopsis
thaliana] >gi|7269241|emb|CAB81310.1| (AL161560)
UDPglucose 4-epimerase-like protein [Arabidopsis
thaliana]
Length = 350
Score = 89.3 bits (218), Expect = 6e-17
Identities = 90/348 (25%), Positives = 155/348 (43%), Gaps = 36/348 (10%)
Query: 3 ILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDI-----QDDPRYTFVK 57
+LVTGG G+IGS+ + +LE + + +D S+ A+L+ + ++ R +F +
Sbjct: 5 VLVTGGAGYIGSHTVLQLLE--GGYSAVVVDNYD-NSSAASLQRVKKLAGENGNRLSFHQ 61
Query: 58 GDVADFELVRELIK--KVDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKENP 115
D+ D + ++ K DA++HFA V S+ P + ++N++GT TLLE + +
Sbjct: 62 VDLRDRPALEKIFSETKFDAVIHFAGLKAVGESVEKPLLYYNNNIVGTVTLLE-VMAQYG 120
Query: 116 GVRLVHISTDEVYGDILKGSFTEEDRLMPSSPYSATKAASDMLVLGWARTYG-LNASITR 174
LV S+ VYG + TEE + ++PY TK + + R+ + R
Sbjct: 121 CKNLVFSSSATVYGWPKEVPCTEESPISATNPYGRTKLFIEEICRDVHRSDSEWKIILLR 180
Query: 175 CTNNYG----------PYQFPEKLIPKTIIRAKMGLK--VPIYGT------GKNVRDWLY 216
N G P P L+P + + +G + + ++GT G VRD+++
Sbjct: 181 YFNPVGAHPSGYIGEDPLGVPNNLMP-YVQQVAVGRRPHLTVFGTDYKTKDGTGVRDYIH 239
Query: 217 VED----HVRAIEAVLLKGEAREIYNISAGEERTNLEVVRTILRIMDKDESLIEFVEDRP 272
V D H+ A+ + + E+YN+ G + LE+V + K L+ RP
Sbjct: 240 VMDLADGHIAALRKLDDLKISCEVYNLGTGNGTSVLEMVAAFEKASGKKIPLV-MAGRRP 298
Query: 273 GHDIRYSLDSWKIIRELKWRPKYRFEEGIKKTVEWYLENEWWWKPLIN 320
G + K REL W+ K EE + W N + + N
Sbjct: 299 GDAEVVYASTEKAERELNWKAKNGIEEMCRDLWNWASNNPYGYNSSSN 346
>pir||F82419 UDP-glucose 4-epimerase VCA0774 [imported] - Vibrio cholerae (group
O1 strain N16961) >gi|9658197|gb|AAF96672.1| (AE004405)
UDP-glucose 4-epimerase [Vibrio cholerae]
Length = 338
Score = 89.3 bits (218), Expect = 6e-17
Identities = 90/344 (26%), Positives = 159/344 (46%), Gaps = 44/344 (12%)
Query: 1 MRILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQD--DPRYTFVKG 58
M++LVTGGMG+IGS+ +++ + LD L Y S L I+ R FV+G
Sbjct: 1 MKVLVTGGMGYIGSHTCIQMIQA--GMTPVILDNL-YNSKVTVLDRIEKVIGVRPQFVQG 57
Query: 59 DVADFELVRELIKK--VDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKENPG 116
D+ D L+ +L+++ ++A+VHFA V S+ P + +NV GT L+ A+R+ G
Sbjct: 58 DIRDKALLVDLMQQHNIEAVVHFAGLKAVGESVQKPLEYYDNNVNGTLVLVAAMRE--AG 115
Query: 117 VR-LVHISTDEVYGDILKGSFTEEDRLMPSSPYSATKAASDMLVLGWARTY-GLNASITR 174
V+ LV S+ VYG+ TE ++PY +K + + + + + ++ R
Sbjct: 116 VKSLVFSSSATVYGEPTSVPITESFPTKAANPYGRSKLMVEECLTDFQKANPDWSITLLR 175
Query: 175 CTNNYG----------PYQFPEKLIPKTIIRAKMGLK--VPIYGT------GKNVRDWLY 216
N G P P L+P + + +G + + ++G+ G VRD+++
Sbjct: 176 YFNPVGSHPSGELGEDPQGIPNNLMP-FVTQVAVGRREYLSVFGSDYPTKDGTGVRDYIH 234
Query: 217 VED----HVRAIEAVLLKGEAREIYNISAGEERTNLEVVRTILRIMDKDESLIEFVEDRP 272
V D H+ A++ V IYN+ G+ + L+VV+ + + V+ RP
Sbjct: 235 VMDLADGHIAALKKVGTCA-GLHIYNLGTGKGYSVLDVVKAFETASGRTVP-YKLVDRRP 292
Query: 273 GHDIRYSLDSWKIIRELKWRPKYRFEEGIKKTVEWYLENEWWWK 316
G Y D K ++L W+ + + ++ W W+
Sbjct: 293 GDIAEYWADPTKAAQDLGWK--------ATRNLHTMAQDAWCWQ 328
>pir||S74751 CDP-glucose 4,6-dehydratase - Synechocystis sp. (strain PCC 6803)
>gi|1651976|dbj|BAA16902.1| (D90901) CDP-glucose
4,6-dehydratase [Synechocystis sp.]
Length = 360
Score = 88.2 bits (215), Expect = 1e-16
Identities = 88/331 (26%), Positives = 152/331 (45%), Gaps = 19/331 (5%)
Query: 3 ILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDVAD 62
+ +TG GF GS ++ + +LD LT N L +I R + + DV D
Sbjct: 12 VFLTGHTGFKGSWLTLWLSQLGAKVSGYSLDPLT-NPNLCELAEIAKCLR-SDTRADVND 69
Query: 63 FELVRELIKKV--DAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKENPGVRLV 120
+++ I + + + H AA+ V RS P +NV+GT LLEA+R + +V
Sbjct: 70 LANLQKAIAEARPEIVFHLAAQPLVRRSYRDPVGTFATNVMGTAHLLEALRASDSVRVVV 129
Query: 121 HISTDEVYGDI-LKGSFTEEDRLMPSSPYSATKAASDMLVLGW----ARTYGLNASITRC 175
++TD+VY ++ + E+D+L PYSA+KAA +++V + R G+ + R
Sbjct: 130 IVTTDKVYRNVEWCWPYREDDQLGGHDPYSASKAACEIVVASYRDAFLREQGVAVASARA 189
Query: 176 TNNYGPYQFPEKLIPKTIIRAKMGLKVPIYGTGKNVRDWLYVED----HVRAIEAVLLKG 231
N G + E + ++RA + I + +R W +V + ++ + +
Sbjct: 190 GNVIGGGDWSEDRLIPDVVRALDAKTMVIIRRPQAIRPWQHVLEPLAGYLLLAQKLWHSP 249
Query: 232 EAREIYNISAGEERTNLEVVRTILRIMDKDES--LIEFVEDRPG-HDIRY-SLDSWKIIR 287
E YN+ G E + VR IL + E +E+ + G H+ + SL+ K
Sbjct: 250 ELAGAYNL--GPETKDAATVRQILEFASRIEPGLQVEYGDGNEGPHEAGWLSLEIAKART 307
Query: 288 ELKWRPKYRFEEGIKKTVEWYLENEWWWKPL 318
L +RP + EE +++T+ WY PL
Sbjct: 308 LLGYRPSWGVEEAVRRTMIWYRSQRQGESPL 338
>pir||S74768 UDPglucose 4-epimerase (EC 5.1.3.2) - Synechocystis sp. (strain
PCC 6803) >gi|1651993|dbj|BAA16919.1| (D90901)
UDP-glucose 4-epimerase [Synechocystis sp.]
Length = 340
Score = 87.8 bits (214), Expect = 2e-16
Identities = 94/346 (27%), Positives = 160/346 (46%), Gaps = 38/346 (10%)
Query: 2 RILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQDDPRYTFVKGDVA 61
+ILVTGG G+IGS+ +R + E + ++ D + G P+++ Q V GD+A
Sbjct: 8 KILVTGGAGYIGSSVVRQLGEA--GYSIVVYDNCSTGF-PSSILYGQ------LVIGDLA 58
Query: 62 DFELVRELIKKVD--AIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKENPGVRL 119
D E + ++ + + A++HFA V S+ P N+ +N T +L+ + RL
Sbjct: 59 DTERLHQVFHEHEILAVMHFAGSLIVPESLIHPLNYYANNTSNTLSLIRCCQIFGVN-RL 117
Query: 120 VHISTDEVYGDILKGSFTEEDRLMPSSPYSATKAASDMLVLGWARTYGLNASITRCTN-- 177
+ ST VYG+ +E + P +PY +K AS+ ++ +A++ L I R N
Sbjct: 118 IFSSTAAVYGNSSSNPISEAEIPCPINPYGRSKLASEWIIQDYAKSSALQYVILRYFNVA 177
Query: 178 ------NYGPYQFPEKLIPKTIIRAKMGLK--VPIYGT------GKNVRDWLYVEDHVRA 223
G + +++ A + LK + I+GT G VRD+++VED +A
Sbjct: 178 GADPEGRLGQMSKTTTHLVRSVCDAILNLKPSLDIFGTDFPTRDGTAVRDYIHVEDLAKA 237
Query: 224 -IEAV--LLKGEAREIYNISAGEERTNLEVVRTILRIMDKDESLIEFVEDRPGHDIRYSL 280
++A+ L G +I N G+ + EVV I D L+ E R G
Sbjct: 238 HLDALRYLENGGESQILNCGYGQGYSVREVVDRAKAISGVD-FLVRETERRLGDPASVIA 296
Query: 281 DSWKIIRELKWRPKYRFEEGIKKT-VEWYLENEWWWKPLINERVLH 325
+ I + L W PKY + I +T + W ++ + +N R +H
Sbjct: 297 CADSIRQVLNWTPKYNNLDIILRTALAWEIK-----RNNLNNRRIH 337
>sp|Q57301|GALE_YEREN UDP-GLUCOSE 4-EPIMERASE (GALACTOWALDENASE) (UDP-GALACTOSE
4-EPIMERASE) >gi|1163935|gb|AAC44470.1| (U43708)
Description: homolog of galE; UDP galactose epimerase
homolog; Method: conceptual translation supplied by
author [Yersinia enterocolitica]
>gi|1197656|gb|AAC60777.1| (U46859) GalE [Yersinia
enterocolitica (type 0:8)] >gi|1588475|prf||2208415E
UDP-galactose 4-epimerase [Yersinia enterocolitica]
Length = 336
Score = 85.0 bits (207), Expect = 1e-15
Identities = 90/344 (26%), Positives = 159/344 (46%), Gaps = 41/344 (11%)
Query: 1 MRILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLKDIQD--DPRYTFVKG 58
M IL+TGG G+IGS+ + +LE+ + V+ LD L S+ +L + + F G
Sbjct: 1 MSILITGGAGYIGSHTVLTLLEQGRN--VVVLDNLI-NSSAESLARVSKICGRKPNFYHG 57
Query: 59 DVADFELVRELIK--KVDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKENPG 116
D+ D ++ + K+D+++HFA V S+ P + +NV+G+ TLLE + N
Sbjct: 58 DILDRSCLKLIFSSHKIDSVIHFAGLKSVGESVEKPIEYYQNNVVGSITLLEEMCLANV- 116
Query: 117 VRLVHISTDEVYGDILKGSFTEEDRL-MPSSPYSATKAASDMLVLGWARTY-GLNASITR 174
+L+ S+ VYG+ TE+ R+ ++PY +K + ++ ++ + + + R
Sbjct: 117 KKLIFSSSATVYGEPEFVPLTEKARIGGTTNPYGTSKVMVEQILKDFSLAHPDYSITALR 176
Query: 175 CTNNYG----------PYQFPEKLIPKTIIRAKMG--LKVPIYGT------GKNVRDWLY 216
N G P P L+P I + +G K+ +YG G +RD+++
Sbjct: 177 YFNPVGAHPSGLIGEDPNGKPNNLLP-FITQVAIGKLSKLLVYGNDYDTPDGSGIRDYIH 235
Query: 217 VEDHVRAIEAVLLK-GEAREIYNISAGEERTNLEVVRTILRIMDKDESLIEFVEDRPGHD 275
V D + L+ IYN+ G + L +++ RI K+ + V RPG D
Sbjct: 236 VMDLAEGHLSTLINLTSGFRIYNLGTGVGYSVLHMIKEFERITGKNIP-FDIVSRRPG-D 293
Query: 276 IRYSLDSWKIIR-ELKWRPKYRFEEGIKKTVEWYLENEWWWKPL 318
I S ++ EL W K+T+ L++ W W+ +
Sbjct: 294 IAECWASPELAHLELGWY--------AKRTLVDMLQDAWKWQKM 329
>gb|AAF78483.1|AC012187_3 (AC012187) Strong similarity to UDPglucose 4-epimerase from
Arabidopsis thaliana gi|2129759 and is a member of the
NAD dependent Epimerase/Dehydratase PF|01370 family.
ESTs gb|AI100184, gb|T22969, gb|T22968, gb|H76416,
gb|AI998807 come from this gene
Length = 351
Score = 78.4 bits (190), Expect = 1e-13
Identities = 86/346 (24%), Positives = 149/346 (42%), Gaps = 38/346 (10%)
Query: 3 ILVTGGMGFIGSNFIRYILEKHNDWEVI-NLDKLTYGSNPANLKDIQDD--PRYTFVKGD 59
ILVTGG GFIG++ + +L+ +I N D + + + D + F GD
Sbjct: 9 ILVTGGAGFIGTHTVVQLLKDGFKVSIIDNFDNSVIEAVDRVRELVGPDLSKKLDFNLGD 68
Query: 60 VADFELVRELIKK--VDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKENPGV 117
+ + + +L K DA++HFA V S+ +P + +N++GT L E + K N +
Sbjct: 69 LRNKGDIEKLFSKQRFDAVIHFAGLKAVGESVENPRRYFDNNLVGTINLYETMAKYNCKM 128
Query: 118 RLVHISTDEVYGDILKGSFTEEDRLMPSSPYSATKAASD--------------MLVLGWA 163
+V S+ VYG K E+ L +PY TK + +++L +
Sbjct: 129 -MVFSSSATVYGQPEKIPCMEDFELKAMNPYGRTKLFLEEIARDIQKAEPEWRIILLRYF 187
Query: 164 RTYGLNASITRCTNNYGPYQFPEKLIPKTIIRAKMGL--KVPIYG------TGKNVRDWL 215
G + S + P P L+P I + +G ++ +YG G VRD++
Sbjct: 188 NPVGAHES---GSIGEDPKGIPNNLMP-YIQQVAVGRLPELNVYGHDYPTEDGSAVRDYI 243
Query: 216 YVED----HVRAIEAVLLKGE-AREIYNISAGEERTNLEVVRTILRIMDKDESLIEFVED 270
+V D H+ A+ + + YN+ G+ + LE+V + K + I+
Sbjct: 244 HVMDLADGHIAALRKLFADPKIGCTAYNLGTGQGTSVLEMVAAFEKASGK-KIPIKLCPR 302
Query: 271 RPGHDIRYSLDSWKIIRELKWRPKYRFEEGIKKTVEWYLENEWWWK 316
R G + K +EL W+ KY +E + +W N W ++
Sbjct: 303 RSGDATAVYASTEKAEKELGWKAKYGVDEMCRDQWKWANNNPWGYQ 348
>sp|O65780|GAE1_CYATE UDP-GLUCOSE 4-EPIMERASE GEPI42 (GALACTOWALDENASE) (UDP-GALACTOSE
4-EPIMERASE) >gi|7437271|pir||T10496 UDPglucose
4-epimerase (EC 5.1.3.2) (clone GEPI42) - guar
>gi|3021355|emb|CAA06338.1| (AJ005081) UDP-galactose
4-epimerase [Cyamopsis tetragonoloba]
Length = 354
Score = 78.0 bits (189), Expect = 1e-13
Identities = 89/346 (25%), Positives = 149/346 (42%), Gaps = 38/346 (10%)
Query: 3 ILVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGS--NPANLKDIQDDPRYT----FV 56
ILVTGG GFIGS+ + +L++ + V +D L Y S + + + P + F
Sbjct: 12 ILVTGGAGFIGSHTVVQLLKQ--GFHVSIIDNL-YNSVIDAVHRVRLLVGPLLSSNLHFH 68
Query: 57 KGDVADFELVRELIKKV--DAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKEN 114
GD+ + + L K DA++HFA V S+ +P N+ +N++ T L + + K N
Sbjct: 69 HGDLRNIHDLDILFSKTKFDAVIHFAGLKGVGESVLNPSNYYDNNLVATINLFQVMSKFN 128
Query: 115 PGVRLVHISTDEVYGDILKGSFTEEDRLMPSSPYSATKAASDMLVLGWARTYG-LNASIT 173
+LV S+ VYG + E+ L +PY +K + + R +
Sbjct: 129 -CKKLVISSSATVYGQPDQIPCVEDSNLHAMNPYGRSKLFVEEVARDIQRAEAEWRIILL 187
Query: 174 RCTNNYG----------PYQFPEKLIP--KTIIRAKMGLKVPIYG------TGKNVRDWL 215
R N G P P L+P + + A++ ++ IYG G +RD++
Sbjct: 188 RYFNPVGAHESGQIGEDPRGLPNNLMPYIQQVAVARLP-ELNIYGHDYPTKDGTAIRDYI 246
Query: 216 YVED----HVRAIEAVLLKGE-AREIYNISAGEERTNLEVVRTILRIMDKDESLIEFVED 270
+V D H+ A+ + YN+ G + LE+V + K + I+
Sbjct: 247 HVMDLADGHIAALRKLFTTDNIGCTAYNLGTGRGTSVLEMVAAFEKASGK-KIPIKMCPR 305
Query: 271 RPGHDIRYSLDSWKIIRELKWRPKYRFEEGIKKTVEWYLENEWWWK 316
RPG + K +EL W+ KY EE + +W N W ++
Sbjct: 306 RPGDATAVYASTEKAEKELGWKAKYGVEEMCRDQWKWASNNPWGYQ 351
>pir||S62783 UDPglucose 4-epimerase (EC 5.1.3.2) - Arabidopsis thaliana
>gi|1143392|emb|CAA90941.1| (Z54214) uridine diphosphate
glucose epimerase [Arabidopsis thaliana]
Length = 351
Score = 75.7 bits (183), Expect = 7e-13
Identities = 85/346 (24%), Positives = 147/346 (41%), Gaps = 38/346 (10%)
Query: 3 ILVTGGMGFIGSNFIRYILEKHNDWEVI-NLDKLTYGSNPANLKDIQDD--PRYTFVKGD 59
ILVTGG GFIG++ + +L+ +I N D + + + D + F GD
Sbjct: 9 ILVTGGAGFIGTHTVVQLLKDGFKVSIIDNFDNSVIEAVDRVRELVGPDLSKKLDFNLGD 68
Query: 60 VADFELVRELIKK--VDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKENPGV 117
+ + + +L K DA++HFA V S+ + +N++GT L E + K N +
Sbjct: 69 LRNKGDIEKLFSKQRFDAVIHFAGLKAVGESVEKGRRYFDNNLVGTINLYETMAKYNCKM 128
Query: 118 RLVHISTDEVYGDILKGSFTEEDRLMPSSPYSATKAASD--------------MLVLGWA 163
+V S+ VYG K E+ L +PY TK + +++L +
Sbjct: 129 -MVFSSSATVYGQPEKIPCMEDFELKAMNPYGRTKLFLEEIARDIQKAEPEWRIILLRYF 187
Query: 164 RTYGLNASITRCTNNYGPYQFPEKLIPKTIIRAKMGL--KVPIYG------TGKNVRDWL 215
G + S + P P L+P I + +G ++ +YG G VRD++
Sbjct: 188 NPVGAHES---GSIGEDPKGIPNNLMP-YIQQVAVGRLPELNVYGHDYPTEDGSAVRDYI 243
Query: 216 YVED----HVRAIEAVLLKGE-AREIYNISAGEERTNLEVVRTILRIMDKDESLIEFVED 270
+V D H+ A+ + + YN+ G+ + LE+V + K + I+
Sbjct: 244 HVMDLADGHIAALRKLFADPKIGCTAYNLGTGQGTSVLEMVAAFEKASGK-KIPIKLCPR 302
Query: 271 RPGHDIRYSLDSWKIIRELKWRPKYRFEEGIKKTVEWYLENEWWWK 316
R G + K +EL W+ KY +E + +W N W ++
Sbjct: 303 RSGDATAVYASTEKAEKELGWKAKYGVDEMCRDQWKWAFNNPWGYQ 348
>sp|P09609|GALX_KLULA GAL10 BIFUNCTIONAL PROTEIN [INCLUDES: UDP-GLUCOSE 4-EPIMERASE
(GALACTOWALDENASE); ALDOSE 1-EPIMERASE (MUTAROTASE)]
>gi|68389|pir||XUVKG UDPglucose 4-epimerase (EC 5.1.3.2)
- yeast (Kluyveromyces marxianus var. lactis)
>gi|2819|emb|CAA30090.1| (X07039) transferase (GAL10)
(AA 1 - 687) [Kluyveromyces lactis]
Length = 687
Score = 70.6 bits (170), Expect = 2e-11
Identities = 80/343 (23%), Positives = 149/343 (43%), Gaps = 36/343 (10%)
Query: 4 LVTGGMGFIGSNFIRYILEKHNDWEVINLDKLTYGSNPANLK-DIQDDPRYTFVKGDVAD 62
LVTGG G+IGS+ + + E ++ I +D L+ S + + ++ F K D+ +
Sbjct: 8 LVTGGAGYIGSHTVVELCEA--GYKCIVVDNLSNSSYESVARMELLTGQEIKFAKIDLCE 65
Query: 63 FELVRELIK--KVDAIVHFAAESHVDRSISSPDNFLHSNVIGTYTLLEAIRKENPGVRLV 120
E + +L K+D+++HFA V S P + +N++GT LLE + K + +LV
Sbjct: 66 LEPLNKLFDDYKIDSVLHFAGLKAVGESTQIPLTYYFNNIVGTINLLECM-KSHDVKKLV 124
Query: 121 HISTDEVYGDILKGS----FTEEDRLMPSSPYSATK-AASDMLVLGWARTYGLNASITRC 175
S+ VYGD + E P++PY TK DM+ + +I R
Sbjct: 125 FSSSATVYGDATRFENMIPIPETCPTGPTNPYGKTKLTIEDMMRDLHFSDKSFSFAILRY 184
Query: 176 TNNYG---------PYQFPEKLIPKTIIRAKMGLKVPIYGTGKN--------VRDWLYVE 218
N G + P L+P + + +G + +Y G + +RD+++V
Sbjct: 185 FNPIGAHPSGVIGEAFGIPNNLLP-FMAQVAIGRRPKLYVFGDDYDSVDGTPIRDYIHVV 243
Query: 219 D----HVRAIEAV-LLKGEAREIYNISAGEERTNLEVVRTILRIMDKDESLIEFVEDRPG 273
D H+ A++ + G RE +N+ G T L++ R + + + R G
Sbjct: 244 DLAKGHLAALKYLEKYAGTCRE-WNLGTGHGTTVLQMYRAFCDAIGFNFEYV-VTARRDG 301
Query: 274 HDIRYSLDSWKIIRELKWRPKYRFEEGIKKTVEWYLENEWWWK 316
+ + + EL+W+ + + +W +N + ++
Sbjct: 302 DVLNLTAKCDRATNELEWKTELDVNKACVDLWKWTQDNPFGYQ 344
Database: ./suso.pep
Posted date: Jul 6, 2001 5:57 PM
Number of letters in database: 840,471
Number of sequences in database: 2977
Database: /banques/blast2/nr.pep
Posted date: Dec 14, 2000 12:46 PM
Number of letters in database: 188,266,275
Number of sequences in database: 595,510
Lambda K H
0.319 0.139 0.426
Gapped
Lambda K H
0.270 0.0470 0.230
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 134665129
Number of Sequences: 2977
Number of extensions: 5809958
Number of successful extensions: 19031
Number of sequences better than 1.0e-10: 375
Number of HSP's better than 0.0 without gapping: 134
Number of HSP's successfully gapped in prelim test: 241
Number of HSP's that attempted gapping in prelim test: 17803
Number of HSP's gapped (non-prelim): 383
length of query: 333
length of database: 189,106,746
effective HSP length: 52
effective length of query: 281
effective length of database: 157,985,422
effective search space: 44393903582
effective search space used: 44393903582
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 41 (21.7 bits)
S2: 165 (68.7 bits)