BLASTP 2.0.10 [Aug-26-1999]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= PAB0801 (PAB0801) DE:transcriptional regulatory protein, Sir2
family
(250 letters)
Database: ./suso.pep; /banques/blast2/nr.pep
598,487 sequences; 189,106,746 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
pir||C75101 transcription regulatory protein, sir2 family PAB080... 508 e-143
pir||F71085 hypothetical protein PH0947 - Pyrococcus horikoshii ... 443 e-124
gi|11499266 transcriptional regulatory protein, Sir2 family [Arc... 297 7e-80
pir||D72562 hypothetical protein APE1782 - Aeropyrum pernix (str... 282 2e-75
pir||C70486 conserved hypothetical protein aq_2170 - Aquifex aeo... 261 5e-69
gi|11497732 transcriptional regulatory protein, Sir2 family [Arc... 257 1e-67
pir||A83506 probable cobalamin biosynthetic protein PA1125 [impo... 214 9e-55
gb|AAK42615.1| Transcriptional regulatory protein, Sir2 protein ... 213 2e-54
gi|6912664 sir2-like 5; sirtuin type 5 [Homo sapiens] >gi|522532... 190 1e-47
pir||H70554 hypothetical protein Rv1151c - Mycobacterium tubercu... 187 9e-47
dbj|BAA91107.1| (AK000355) unnamed protein product [Homo sapiens] 183 1e-45
pir||A72370 regulatory protein, SIR2 family - Thermotoga maritim... 178 7e-44
pir||E82191 probable nicotinate-nucleotide--dimethylbenzimidazol... 174 1e-42
pir||G75570 conserved hypothetical protein - Deinococcus radiodu... 169 4e-41
gb|AAC78722.1| (U89687) putative nicotinic acid mononucleotide:5... 166 2e-40
gi|11418990 sir2-like 5 [Homo sapiens] 161 1e-38
pir||E64856 hypothetical protein b1120 - Escherichia coli >gi|17... 160 1e-38
pir||A83495 hypothetical protein PA1197 [imported] - Pseudomonas... 150 1e-35
dbj|BAB04626.1| (AP001510) transcriptional regulator [Bacillus h... 144 9e-34
dbj|BAB09243.1| (AB009050) transcription regulator Sir2-like pro... 137 1e-31
gb|AAC70895.1| (AF006830) unknown [Actinobacillus actinomycetemc... 136 3e-31
pir||A71838 hypothetical protein jhp1180 - Helicobacter pylori (... 131 7e-30
gb|AAD42226.1|AF159133_1 (AF159133) SIR2-like protein [Oryza sat... 129 3e-29
emb|CAC05449.1| (AL391712) SIR2-family protein [Arabidopsis thal... 124 9e-28
gb|AAD15478.1| (AC006930) R33423_1 [Homo sapiens] 123 1e-27
pir||H69827 conserved hypothetical protein yhdZ - Bacillus subti... 122 6e-27
gi|6912662 sir2-like 4; sirtuin type 4 [Homo sapiens] >gi|114366... 121 1e-26
pir||T24172 hypothetical protein R11A8.4 - Caenorhabditis elegan... 118 8e-26
gi|7706710 sir2-related protein type 6; sirtuin type 6 [Homo sap... 116 2e-25
gi|11425892 sir2-related protein type 6 [Homo sapiens] 115 4e-25
gb|AAA67853.1| (M32103) ORF-27 [Staphylococcus aureus] 115 7e-25
gi|6912660 sir2-like 3; sirtuin type 3 [Homo sapiens] >gi|522532... 115 7e-25
pir||G81307 probable transferase Cj1050c [imported] - Campylobac... 114 1e-24
gb|AAB95634.1| (AC003982) unknown function; 60% similar to Z5017... 113 2e-24
gi|11441548 sir2-like 3 [Homo sapiens] 113 3e-24
gb|AAF77189.1|AF264911_5 (AF264911) putative transferase [Campyl... 111 6e-24
emb|CAB56682.1| (AL121596) putative SIR2-like regulatory protein... 110 2e-23
gb|AAC79684.1| (AF068758) SIR2 [Drosophila melanogaster] 107 2e-22
gi|6912656 SIR2 (silent mating type information regulation 2, S.... 103 2e-21
gb|AAD45971.1|AF095714_1 (AF095714) silencing information regula... 103 2e-21
gb|AAF53248.1| (AE003639) Sir2 gene product [Drosophila melanoga... 103 2e-21
gi|11433001 SIR2 (silent mating type information regulation 2, S... 103 2e-21
pir||T22325 hypothetical protein F46G10.3 - Caenorhabditis elega... 103 2e-21
pir||T40929 transcription regulator SIR2 homolog - fission yeast... 102 3e-21
gi|7657575 sir2-like 1; sirtuin type 1 [Homo sapiens] >gi|114309... 102 5e-21
emb|CAC04174.1| (AL133551) bA57G10.4 (SIRT1, Sir2-like proteins ... 102 5e-21
pir||C64677 conserved hypothetical protein HP1259 - Helicobacter... 101 7e-21
pir||T22324 hypothetical protein F46G10.7 - Caenorhabditis elega... 101 7e-21
gb|AAD20046.1| (AF131800) Similar to rat 5E5 antigen [Homo sapiens] 101 9e-21
gi|9790229 Sir2 alpha protein; Sir2 alpha [Mus musculus] >gi|669... 101 9e-21
gb|AAG22161.1| (AE003730) CG5085 gene product [Drosophila melano... 101 9e-21
gb|AAG33227.1| (AF302278) SIR2L3 [Mus musculus] >gi|11612479|gb|... 100 3e-20
pir||T35951 probable SIR2 family transcription regulator - Strep... 98 8e-20
gb|AAG39256.1| (AF299337) SIR2L2 [Mus musculus] 98 1e-19
pir||T18247 transcription regulatory protein - yeast (Candida al... 98 1e-19
gi|6325242 similar to Sir2p; Hst2p [Saccharomyces cerevisiae] >g... 96 5e-19
gb|AAG32038.1| (AF302272) SIR2L2 [Mus musculus] 94 2e-18
sp|Q25337|SIR2_LEIMA REGULATORY PROTEIN SIR2 HOMOLOG (LMSIR2RP) ... 92 5e-18
gb|AAF54513.1| (AE003686) CG6284 gene product [Drosophila melano... 91 1e-17
gb|AAC73004.1| (AF102869) Sir2 homolog [Trypanosoma brucei] 89 5e-17
gb|AAF46055.1| (AE003435) CG3187 gene product [Drosophila melano... 89 5e-17
pir||T25520 hypothetical protein C06A5.3 - Caenorhabditis elegan... 86 3e-16
gi|7706712 sir2-related protein type 7; sirtuin type 7 [Homo sap... 79 4e-14
gi|11427386 sir2-related protein type 7 [Homo sapiens] 79 4e-14
sp|O59923|SIR2_CANAL REGULATORY PROTEIN SIR2 >gi|3005095|gb|AAC0... 78 8e-14
gi|6324504 Homolog of SIR2; Hst1p [Saccharomyces cerevisiae] >gi... 78 1e-13
pir||T39571 probable regulatory protein sir2-like - fission yeas... 78 1e-13
gb|AAF56851.2| (AE003768) CG11305 gene product [Drosophila melan... 76 5e-13
gi|6324599 involved in telomeric silencing; Hst3p [Saccharomyces... 73 3e-12
gb|AAF67015.1|AF160214_1 (AF160214) silent information regulator... 68 9e-11
>pir||C75101 transcription regulatory protein, sir2 family PAB0801 - Pyrococcus
abyssi (strain Orsay) >gi|5458624|emb|CAB50112.1|
(AJ248286) transcriptional regulatory protein, Sir2
family [Pyrococcus abyssi]
Length = 250
Score = 508 bits (1295), Expect = e-143
Identities = 250/250 (100%), Positives = 250/250 (100%)
Query: 1 MIVEVARVLASSKNAIAFTGAGISAESGVPTFRGKDGLWNKYRPEELATPEAFARNPKLV 60
MIVEVARVLASSKNAIAFTGAGISAESGVPTFRGKDGLWNKYRPEELATPEAFARNPKLV
Sbjct: 1 MIVEVARVLASSKNAIAFTGAGISAESGVPTFRGKDGLWNKYRPEELATPEAFARNPKLV 60
Query: 61 WEFYKWRINKILKAKPNPAHYALVELEDMGILRAVITQNVDDLHREAGTRNLIELHGNIF 120
WEFYKWRINKILKAKPNPAHYALVELEDMGILRAVITQNVDDLHREAGTRNLIELHGNIF
Sbjct: 61 WEFYKWRINKILKAKPNPAHYALVELEDMGILRAVITQNVDDLHREAGTRNLIELHGNIF 120
Query: 121 RVKCTKCNFKEYLKESQRLEEVLKEDLPKCPRCGSLLRPDVVWFGEPLPREELDRAFKLA 180
RVKCTKCNFKEYLKESQRLEEVLKEDLPKCPRCGSLLRPDVVWFGEPLPREELDRAFKLA
Sbjct: 121 RVKCTKCNFKEYLKESQRLEEVLKEDLPKCPRCGSLLRPDVVWFGEPLPREELDRAFKLA 180
Query: 181 EKADAVLVVGTSGLVYPAAYIPYIVKESGGTVIEVNVEESAITPIADFFLRGRAGEVLPR 240
EKADAVLVVGTSGLVYPAAYIPYIVKESGGTVIEVNVEESAITPIADFFLRGRAGEVLPR
Sbjct: 181 EKADAVLVVGTSGLVYPAAYIPYIVKESGGTVIEVNVEESAITPIADFFLRGRAGEVLPR 240
Query: 241 VVHEVRRLLQ 250
VVHEVRRLLQ
Sbjct: 241 VVHEVRRLLQ 250
>pir||F71085 hypothetical protein PH0947 - Pyrococcus horikoshii
>gi|3257361|dbj|BAA30044.1| (AP000004) 249aa long
hypothetical protein [Pyrococcus horikoshii]
Length = 249
Score = 443 bits (1128), Expect = e-124
Identities = 207/249 (83%), Positives = 233/249 (93%)
Query: 1 MIVEVARVLASSKNAIAFTGAGISAESGVPTFRGKDGLWNKYRPEELATPEAFARNPKLV 60
M+ EVARVLASSKN IAFTGAGISAESG+PTFRGKDGLW KYRPEELATPEAF RNPKLV
Sbjct: 1 MMAEVARVLASSKNVIAFTGAGISAESGIPTFRGKDGLWKKYRPEELATPEAFERNPKLV 60
Query: 61 WEFYKWRINKILKAKPNPAHYALVELEDMGILRAVITQNVDDLHREAGTRNLIELHGNIF 120
W+FYKWRI KILKAKPNPAHYALVELE MGIL+AVITQNVDDLHREAGT+NLIELHGNIF
Sbjct: 61 WDFYKWRIKKILKAKPNPAHYALVELEKMGILKAVITQNVDDLHREAGTKNLIELHGNIF 120
Query: 121 RVKCTKCNFKEYLKESQRLEEVLKEDLPKCPRCGSLLRPDVVWFGEPLPREELDRAFKLA 180
RV+CT C F+E+LKES R++E+L EDLPKCP+CGSLLRPDVVWFGEPLP +EL+ AFKLA
Sbjct: 121 RVRCTSCEFREHLKESGRIDEILSEDLPKCPKCGSLLRPDVVWFGEPLPSKELNEAFKLA 180
Query: 181 EKADAVLVVGTSGLVYPAAYIPYIVKESGGTVIEVNVEESAITPIADFFLRGRAGEVLPR 240
++AD V+VVGTSGLVYPAAYIPYIVK+SGG VIE+NV++S ITPIADFFLRG+AGE+LP+
Sbjct: 181 KEADVVIVVGTSGLVYPAAYIPYIVKDSGGVVIEINVQKSGITPIADFFLRGKAGEILPK 240
Query: 241 VVHEVRRLL 249
+V EVRR+L
Sbjct: 241 LVQEVRRIL 249
>gi|11499266 transcriptional regulatory protein, Sir2 family [Archaeoglobus
fulgidus] >gi|7448869|pir||C69459 transcription
regulator Sir2 family homolog - Archaeoglobus fulgidus
>gi|2648874|gb|AAB89569.1| (AE000987) transcriptional
regulatory protein, Sir2 family [Archaeoglobus fulgidus]
Length = 245
Score = 297 bits (753), Expect = 7e-80
Identities = 135/246 (54%), Positives = 185/246 (74%), Gaps = 5/246 (2%)
Query: 4 EVARVLASSKNAIAFTGAGISAESGVPTFRGKDGLWNKYRPEELATPEAFARNPKLVWEF 63
++ + +A SK +A TGAG+SAESG+PTFRGKDGLWN+YRPEELA P+AFA++P+ VW++
Sbjct: 4 KLLKTIAESKYLVALTGAGVSAESGIPTFRGKDGLWNRYRPEELANPQAFAKDPEKVWKW 63
Query: 64 YKWRINKILKAKPNPAHYALVELEDMGILRAVITQNVDDLHREAGTRNLIELHGNIFRVK 123
Y WR+ K+ A+PN AH A ELE +G+L+ +ITQNVDDLH AG+RN+I LHG++ V+
Sbjct: 64 YAWRMEKVFNAQPNKAHQAFAELERLGVLKCLITQNVDDLHERAGSRNVIHLHGSLRVVR 123
Query: 124 CTKCNFKEYLKESQRLEEVLKEDLPKCPRCGSLLRPDVVWFGEPLPREELDRAFKLAEKA 183
CT CN ++ + ++ LPKC +CGSLLRP VVWFGE LP + LDRA + E+A
Sbjct: 124 CTSCNNSFEVESAPKI-----PPLPKCDKCGSLLRPGVVWFGEMLPPDVLDRAMREVERA 178
Query: 184 DAVLVVGTSGLVYPAAYIPYIVKESGGTVIEVNVEESAITPIADFFLRGRAGEVLPRVVH 243
D ++V GTS +V PAA +P IVK+ GG +IE+N +E+ +TPIAD+ LRG+AGEV+ +V
Sbjct: 179 DVIIVAGTSAVVQPAASLPLIVKQRGGAIIEINPDETPLTPIADYSLRGKAGEVMDELVR 238
Query: 244 EVRRLL 249
VR+ L
Sbjct: 239 HVRKAL 244
>pir||D72562 hypothetical protein APE1782 - Aeropyrum pernix (strain K1)
>gi|5105472|dbj|BAA80785.1| (AP000062) 247aa long
hypothetical protein [Aeropyrum pernix]
Length = 247
Score = 282 bits (715), Expect = 2e-75
Identities = 135/239 (56%), Positives = 174/239 (72%), Gaps = 8/239 (3%)
Query: 4 EVARVLASSKNAIAFTGAGISAESGVPTFRGKDGLWNKYRPEELATPEAFARNPKLVWEF 63
E AR+LA+S+ A+AFTGAGISAESG+PTFRGKDGLW+++ P +LATPEAF R+P+LVWE+
Sbjct: 8 ESARILANSRFAVAFTGAGISAESGIPTFRGKDGLWSRFDPRDLATPEAFNRDPRLVWEW 67
Query: 64 YKWRINKILKAKPNPAHYALVELEDMGILRAVITQNVDDLHREAGTRNLIELHGNIFRVK 123
Y WRI ++L AKPN AH L LED G+L+AVITQNVD LHR AG+R ++ELHGN+ R +
Sbjct: 68 YSWRIERVLAAKPNKAHRLLARLEDSGVLKAVITQNVDGLHRRAGSRRVLELHGNVLRAR 127
Query: 124 CTKCNFK-EYLKESQRLEEVLKEDLPKCPRCGSLLRPDVVWFGEPLPREELDRAFKLAEK 182
CT+C K E+ ++ L P CPRCG +LRPDVVWFGEPL L+ AF LA +
Sbjct: 128 CTRCGSKLEWREKPSNLP-------PSCPRCGGVLRPDVVWFGEPLDTSLLEEAFGLARR 180
Query: 183 ADAVLVVGTSGLVYPAAYIPYIVKESGGTVIEVNVEESAITPIADFFLRGRAGEVLPRV 241
+D ++++GTSG V PA +P KESG T+I VN E + + +AD LR RA E R+
Sbjct: 181 SDVMIIIGTSGAVDPAGLLPLAAKESGATLINVNPEPNRYSGVADIELRMRAVEFAERL 239
>pir||C70486 conserved hypothetical protein aq_2170 - Aquifex aeolicus
>gi|2984374|gb|AAC07893.1| (AE000776) hypothetical
protein [Aquifex aeolicus]
Length = 239
Score = 261 bits (661), Expect = 5e-69
Identities = 127/233 (54%), Positives = 164/233 (69%), Gaps = 5/233 (2%)
Query: 14 NAIAFTGAGISAESGVPTFRGKDGLWNKYRPEELATPEAFARNPKLVWEFYKWRINKILK 73
N + TGAGISAESG+PTFRGKDGLWNK++PEELATPEAF RNPKLVWE+Y W+ I K
Sbjct: 5 NIVTLTGAGISAESGIPTFRGKDGLWNKFKPEELATPEAFFRNPKLVWEWYDWKRQLIAK 64
Query: 74 AKPNPAHYALVELEDMGILRAVITQNVDDLHREAGTRNLIELHGNIFRVKCTKCNFKEYL 133
A+PN H L ++E+ +ITQNVD LH+ AG++ +IELHGNI++V+C +C + Y
Sbjct: 65 AQPNEGHKILTKMEEEFPNFYLITQNVDGLHQRAGSKKVIELHGNIWKVRCVECGNERY- 123
Query: 134 KESQRLEEVLKEDLPKCPRCGSLLRPDVVWFGEPLPREELDRAFKLAEKADAVLVVGTSG 193
L E PKC +CG LLRP VVWFGE LP + L RA++L+ +A +VVGTSG
Sbjct: 124 ----EYTTPLPEIPPKCEKCGGLLRPGVVWFGESLPVDALSRAYELSREAHVFIVVGTSG 179
Query: 194 LVYPAAYIPYIVKESGGTVIEVNVEESAITPIADFFLRGRAGEVLPRVVHEVR 246
+VYPAA +P++ KE+G VIEVN EE+ IT IAD + +A L +V +R
Sbjct: 180 VVYPAAELPFVAKENGAQVIEVNPEETPITKIADMHFKEKASTGLKKVYDYLR 232
>gi|11497732 transcriptional regulatory protein, Sir2 family [Archaeoglobus
fulgidus] >gi|7448871|pir||H69263 transcription
regulator Sir2 family homolog - Archaeoglobus fulgidus
>gi|2650531|gb|AAB91115.1| (AE001098) transcriptional
regulatory protein, Sir2 family [Archaeoglobus fulgidus]
Length = 253
Score = 257 bits (649), Expect = 1e-67
Identities = 129/248 (52%), Positives = 179/248 (72%), Gaps = 4/248 (1%)
Query: 2 IVEVARVLASSKNAIAFTGAGISAESGVPTFRGKDGLWNKYRPEELATPEAFARNPKLVW 61
I + A +LA SK+A+ FTGAGISAESG+PTFRG+DGLW KY PEE+A+ F RNP+ W
Sbjct: 5 IRKAAEILAKSKHAVVFTGAGISAESGIPTFRGEDGLWRKYDPEEVASISGFKRNPRAFW 64
Query: 62 EFYKWRINKILKAKPNPAHYALVELEDMGILRAVITQNVDDLHREAGTRNLIELHGNIFR 121
EF +K+ A+PNPAHYA+ ELE MGI++AVITQN+D LH+ AG+R ++ELHG++ +
Sbjct: 65 EFSMEMKDKLF-AEPNPAHYAIAELERMGIVKAVITQNIDMLHQRAGSRRVLELHGSMDK 123
Query: 122 VKCTKCNFKEYLKESQRLEEVLKEDLPKCPRCGSL-LRPDVVWFGEPLPREELDRAFKLA 180
+ C C+ E S+ +E+ K ++P+C +CGS ++P VV FGEPLP+ L A + A
Sbjct: 124 LDCLDCH--ETYDWSEFVEDFNKGEIPRCRKCGSYYVKPRVVLFGEPLPQRTLFEAIEEA 181
Query: 181 EKADAVLVVGTSGLVYPAAYIPYIVKESGGTVIEVNVEESAITPIADFFLRGRAGEVLPR 240
+ DA +VVG+S +VYPAA +PYI K++G +I VN E + PI D + G+AGEVLP+
Sbjct: 182 KHCDAFMVVGSSLVVYPAAELPYIAKKAGAKMIIVNAEPTMADPIFDVKIIGKAGEVLPK 241
Query: 241 VVHEVRRL 248
+V EV+RL
Sbjct: 242 IVEEVKRL 249
>pir||A83506 probable cobalamin biosynthetic protein PA1125 [imported] -
Pseudomonas aeruginosa (strain PAO1)
>gi|9947044|gb|AAG04514.1|AE004542_10 (AE004542)
probable cobalamin biosynthetic protein [Pseudomonas
aeruginosa]
Length = 250
Score = 214 bits (539), Expect = 9e-55
Identities = 110/241 (45%), Positives = 150/241 (61%), Gaps = 3/241 (1%)
Query: 5 VARVLASSKNAIAFTGAGISAESGVPTFRGK-DGLWNKYRPEELATPEAFARNPKLVWEF 63
V +LA ++ + FTGAG+SAESG+PTFR GLW +Y P LATP AFA +P LVW +
Sbjct: 4 VVELLAGARRLVIFTGAGVSAESGIPTFRDALGGLWARYDPAALATPAAFADDPALVWGW 63
Query: 64 YKWRINKILKAKPNPAHYALVELEDMGILRAVITQNVDDLHREAGTRNLIELHGNIFRVK 123
Y+WR K+L +PNPAH A+ L ++TQNVDDLH AG+R+++ LHG++ +
Sbjct: 64 YEWRRLKVLGVQPNPAHRAIAALSGRIANTRLVTQNVDDLHERAGSRDVLHLHGSLHAPR 123
Query: 124 CTKC--NFKEYLKESQRLEEVLKEDLPKCPRCGSLLRPDVVWFGEPLPREELDRAFKLAE 181
C C +++ L +S EE + + P+CP CG +RP VVWFGE LP L AF A
Sbjct: 124 CATCAAAYRDALPDSVEPEEGRRIEPPRCPACGGQVRPGVVWFGEALPEAALREAFAAAC 183
Query: 182 KADAVLVVGTSGLVYPAAYIPYIVKESGGTVIEVNVEESAITPIADFFLRGRAGEVLPRV 241
+ D +L VGTSG+V PAA IP + E G +V+ VN + + L G AGEVLP +
Sbjct: 184 ECDLLLSVGTSGVVQPAARIPGLALEHGASVVHVNPQPVRTRHPREHCLVGPAGEVLPEL 243
Query: 242 V 242
+
Sbjct: 244 L 244
>gb|AAK42615.1| Transcriptional regulatory protein, Sir2 protein homolog
[Sulfolobus solfataricus]
Length = 247
Score = 213 bits (536), Expect = 2e-54
Identities = 113/244 (46%), Positives = 158/244 (64%), Gaps = 5/244 (2%)
Query: 4 EVARVLASSKNAIAFTGAGISAESGVPTFRGKDGLWNKYRPEELATPEAFARNPKLVWEF 63
+VA L SS IAFTGAGIS SG+P FRG GLW KY PE LA+ E F ++PK W F
Sbjct: 5 KVAEELISSSYTIAFTGAGISTASGIPDFRGPQGLWKKYSPE-LASIEYFEKDPKNFWGF 63
Query: 64 YKWRINKILKAKPNPAHYALVELEDMGILRAVITQNVDDLHREAGTRNLIELHGNIFRVK 123
Y R+ + +A+PN AHY+L ELE MGI++ +ITQN+D LH++AG++N+IELHG + R
Sbjct: 64 YSLRMRGLFEAQPNKAHYSLAELEKMGIIKVIITQNIDGLHQKAGSKNVIELHGTMRRSY 123
Query: 124 CTKCNFKEYLKESQRLEEVLKEDLPKCPRCGSLLRPDVVWFGEPLPREELDRAFKLAEKA 183
C C + Y L + K +LP CG ++RPDVV FGEP+ + + A +A ++
Sbjct: 124 CVLC-LRTY-DSLNVLSMIEKGNLPPRCDCGGIIRPDVVLFGEPV--KNIYEALSIAYES 179
Query: 184 DAVLVVGTSGLVYPAAYIPYIVKESGGTVIEVNVEESAITPIADFFLRGRAGEVLPRVVH 243
D V+ +G+S VYPA IP VKE GG +I +N+EE+ + IAD+ +R LP+++
Sbjct: 180 DLVISIGSSLTVYPANLIPQTVKERGGKLIILNMEETPLDSIADYVVREPVEISLPKILE 239
Query: 244 EVRR 247
VR+
Sbjct: 240 NVRQ 243
>gi|6912664 sir2-like 5; sirtuin type 5 [Homo sapiens]
>gi|5225326|gb|AAD40853.1|AF083110_1 (AF083110) sirtuin
type 5 [Homo sapiens]
Length = 310
Score = 190 bits (479), Expect = 1e-47
Identities = 106/262 (40%), Positives = 144/262 (54%), Gaps = 21/262 (8%)
Query: 2 IVEVARVLASSKNAIAFTGAGISAESGVPTFRGKDGLWNKYRPEELATPEAFARNPKLVW 61
+ + + A +K+ + +GAG+SAESGVPTFRG G W K++ ++LATP AFA NP VW
Sbjct: 40 MADFRKFFAKAKHIVIISGAGVSAESGVPTFRGAGGYWRKWQAQDLATPLAFAHNPSRVW 99
Query: 62 EFYKWRINKILKAKPNPAHYALVELE----DMGILRAVITQNVDDLHREAGTRNLIELHG 117
EFY +R + +PN H A+ E E G VITQN+D+LHR+AGT+NL+E+HG
Sbjct: 100 EFYHYRREVMGSKEPNAGHRAIAECETRLGKQGRRVVVITQNIDELHRKAGTKNLLEIHG 159
Query: 118 NIFRVKCTKC-----NFKEYL----------KESQRLEEVLKEDLPKCPR--CGSLLRPD 160
++F+ +CT C N+K + + + + E LP+C CG LLRP
Sbjct: 160 SLFKTRCTSCGVVAENYKSPICPALSGKGAPEPGTQDASIPVEKLPRCEEAGCGGLLRPH 219
Query: 161 VVWFGEPLPREELDRAFKLAEKADAVLVVGTSGLVYPAAYIPYIVKESGGTVIEVNVEES 220
VVWFGE L L+ + D LVVGTS +VYPAA V G V E N E +
Sbjct: 220 VVWFGENLDPAILEEVDRELAHCDLCLVVGTSSVVYPAAMFAPQVAARGVPVAEFNTETT 279
Query: 221 AITPIADFFLRGRAGEVLPRVV 242
T F +G G LP +
Sbjct: 280 PATNRFRFHFQGPCGTTLPEAL 301
>pir||H70554 hypothetical protein Rv1151c - Mycobacterium tuberculosis (strain
H37RV) >gi|2117189|emb|CAB09010.1| (Z95584) hypothetical
protein Rv1151c [Mycobacterium tuberculosis]
Length = 237
Score = 187 bits (471), Expect = 9e-47
Identities = 98/233 (42%), Positives = 141/233 (60%), Gaps = 3/233 (1%)
Query: 19 TGAGISAESGVPTFRG-KDGLWNKYRPEELATPEAFARNPKLVWEFYKWRINKILKAKPN 77
+GAGISAESGVPTFR K+GLW ++ P EL++ + + RNP+ VW +Y WR + +PN
Sbjct: 7 SGAGISAESGVPTFRDDKNGLWARFDPYELSSTQGWLRNPERVWGWYLWRHYLVANVEPN 66
Query: 78 PAHYALVELEDMGILRAVITQNVDDLHREAGTRNLIELHGNIFRVKCTKCNFKEYLKESQ 137
H A+ +D + +VITQNVDDLH AG+ + LHG++F +C +C +
Sbjct: 67 DGHRAIAAWQDHAEV-SVITQNVDDLHERAGSGAVHHLHGSLFEFRCARCGVPYTDALPE 125
Query: 138 RLEEVLKEDLPKCPRCGSLLRPDVVWFGEPLPREELDRAFKLAEKADAVLVVGTSGLVYP 197
E ++ + P C CG L+RPD+VWFGEPLP E A + AD ++VVGTS +VYP
Sbjct: 126 MPEPAIEVEPPVCD-CGGLIRPDIVWFGEPLPEEPWRSAVEATGSADVMVVVGTSAIVYP 184
Query: 198 AAYIPYIVKESGGTVIEVNVEESAITPIADFFLRGRAGEVLPRVVHEVRRLLQ 250
AA +P + G VIEVN E + ++ A +R A + LP ++ + LL+
Sbjct: 185 AAGLPDLALARGTAVIEVNPEPTPLSGSATISIRESASQALPGLLERLPALLK 237
>dbj|BAA91107.1| (AK000355) unnamed protein product [Homo sapiens]
Length = 299
Score = 183 bits (461), Expect = 1e-45
Identities = 101/243 (41%), Positives = 137/243 (55%), Gaps = 21/243 (8%)
Query: 2 IVEVARVLASSKNAIAFTGAGISAESGVPTFRGKDGLWNKYRPEELATPEAFARNPKLVW 61
+ + + A +K+ + +GAG+SAESGVPTFRG G W K++ ++LATP AFA NP VW
Sbjct: 40 MADFRKFFAKAKHIVIISGAGVSAESGVPTFRGAGGYWRKWQAQDLATPLAFAHNPSRVW 99
Query: 62 EFYKWRINKILKAKPNPAHYALVELE----DMGILRAVITQNVDDLHREAGTRNLIELHG 117
EFY +R + +PN H A+ E E G VITQN+D+LHR+AGT+NL+E+HG
Sbjct: 100 EFYHYRREVMGSKEPNAGHRAIAECETRLGKQGRRVVVITQNIDELHRKAGTKNLLEIHG 159
Query: 118 NIFRVKCTKC-----NFKEYL----------KESQRLEEVLKEDLPKCPR--CGSLLRPD 160
++F+ +CT C N+K + + + + E LP+C CG LLRP
Sbjct: 160 SLFKTRCTSCGVVAENYKSPICPALSGKGAPEPGTQDASIPVEKLPRCEEAGCGGLLRPH 219
Query: 161 VVWFGEPLPREELDRAFKLAEKADAVLVVGTSGLVYPAAYIPYIVKESGGTVIEVNVEES 220
VVWFGE L L+ + D LVVGTS +VYPAA V G V E N E +
Sbjct: 220 VVWFGENLDPAILEEVDRELAHCDLCLVVGTSSVVYPAAMFAPQVAARGVPVAEFNTETT 279
Query: 221 AIT 223
T
Sbjct: 280 PAT 282
>pir||A72370 regulatory protein, SIR2 family - Thermotoga maritima (strain
MSB8) >gi|4981001|gb|AAD35575.1|AE001726_9 (AE001726)
regulatory protein, SIR2 family [Thermotoga maritima]
Length = 246
Score = 178 bits (446), Expect = 7e-44
Identities = 96/241 (39%), Positives = 147/241 (60%), Gaps = 3/241 (1%)
Query: 4 EVARVLASSKNAIAFTGAGISAESGVPTFRGKDGLWNKYRPEELATPEAFARNPKLVWEF 63
E +L S+ + TGAGIS SG+P FRG +G++ KY + + + F +P+ + F
Sbjct: 5 EFLDLLNESRLTVTLTGAGISTPSGIPDFRGPNGIYKKYS-QNVFDIDFFYSHPEEFYRF 63
Query: 64 YKWRINKILKAKPNPAHYALVELEDMGILRAVITQNVDDLHREAGTRNLIELHGNIFRVK 123
K I +L+AKPN AH L +LE+ G++ AVITQN+D LH+ AG++ +IELHGN+
Sbjct: 64 AKEGIFPMLQAKPNLAHVLLAKLEEKGLIEAVITQNIDRLHQRAGSKKVIELHGNVEEYY 123
Query: 124 CTKCNFKEYLKESQRLEEVLKEDLPKCPRCGSLLRPDVVWFGEPLPREELDRAFKLAEKA 183
C +C K+Y E ++++ D+P C C SL+RP++V+FGE LP++ L A L+ +A
Sbjct: 124 CVRCE-KKYTVEDV-IKKLESSDVPLCDDCNSLIRPNIVFFGENLPQDALREAIGLSSRA 181
Query: 184 DAVLVVGTSGLVYPAAYIPYIVKESGGTVIEVNVEESAITPIADFFLRGRAGEVLPRVVH 243
++V+G+S +VYPAA +P I SGG ++ VN+ E+ IA E RV+
Sbjct: 182 SLMIVLGSSLVVYPAAELPLITVRSGGKLVIVNLGETPFDDIATLKYNMDVVEFARRVME 241
Query: 244 E 244
E
Sbjct: 242 E 242
>pir||E82191 probable nicotinate-nucleotide--dimethylbenzimidazole
phosphoribosyltransferase (EC 2.4.2.21) VC1509
[imported] - Vibrio cholerae (group O1 strain N16961)
>gi|9656013|gb|AAF94664.1| (AE004229) nicotinate
mononucleotide:5,6-dimethylbenzimidazole
phosphoribosyltransferase [Vibrio cholerae]
Length = 259
Score = 174 bits (436), Expect = 1e-42
Identities = 95/237 (40%), Positives = 145/237 (61%), Gaps = 12/237 (5%)
Query: 13 KNAIAFTGAGISAESGVPTFRGKDGLWNKYRPEELATPEAFARNPKLVWEFYKWRINKIL 72
++ + TGAGISAESG+ TFR +DGLW +R E++ATPE F R+P +V EFY R K+L
Sbjct: 19 RHVVILTGAGISAESGIQTFRAQDGLWENHRIEDVATPEGFQRDPDMVLEFYNQRRRKLL 78
Query: 73 K--AKPNPAHYALVELE-DMGILRAVITQNVDDLHREAGTRNLIELHGNIFRVKCTKCNF 129
+PNPAH AL +LE ++ VITQN+D+LH G++N+I +HG + + +C + N
Sbjct: 79 SDAIQPNPAHLALGKLEKELQGSVTVITQNIDNLHERGGSQNIIHMHGELLKARCPESN- 137
Query: 130 KEYLKESQRLEEVLKEDLPKCPRCGSLLRPDVVWFGE-PLPREELDRAFKLAEKADAVLV 188
+ ++ E++ DL C + + +RP +VWFGE PL ++ + E+AD +
Sbjct: 138 ----QTVEQKEDIRHGDLCHCCQMPAQMRPHIVWFGEMPLRMGDI---YAALEQADLFVS 190
Query: 189 VGTSGLVYPAAYIPYIVKESGGTVIEVNVEESAITPIADFFLRGRAGEVLPRVVHEV 245
+GTSG+VYPAA + + G IE+N+E SA+ G+A +PR+V E+
Sbjct: 191 IGTSGVVYPAAGFVHDARMHGAHTIEINLEPSAVESEFAEKRYGKASIEVPRLVEEI 247
>pir||G75570 conserved hypothetical protein - Deinococcus radiodurans (strain
R1) >gi|6457674|gb|AAF09608.1|AE001865_5 (AE001865)
conserved hypothetical protein [Deinococcus radiodurans]
Length = 246
Score = 169 bits (423), Expect = 4e-41
Identities = 101/242 (41%), Positives = 138/242 (56%), Gaps = 12/242 (4%)
Query: 9 LASSKNAIAFTGAGISAESGVPTFR-GKDGLWNKYRPEELATPEAFARNPKLVWEFYKWR 67
L +++ TGAGISAESG+PTFR + G W ++RPE+LA+P+A+ R+P LVWE+Y R
Sbjct: 10 LKAARRVAVLTGAGISAESGIPTFRDAQTGHWARFRPEDLASPDAYRRDPDLVWEWYAGR 69
Query: 68 INKILKAKPNPAHYALVELEDM-GILRAVITQNVDDLHREAGTRN----LIELHGNIFRV 122
+L A+PN H L ELE G + TQNVD LH AG+ + L+ELHGN+ +
Sbjct: 70 YRDVLAAQPNRGHELLAELERRKGPGFFLATQNVDGLHARAGSGSAGGELVELHGNLLQA 129
Query: 123 KCTKCNFKEYLKESQRLEEVLKEDLPKCPRCGSLLRPDVVWFGEPLPREELDRAFKLAEK 182
+ E E L + LP G +RP +VWFGE LP + LD A +
Sbjct: 130 R------DELTGEVFPLAAPDELTLPPLSPNGQRMRPHIVWFGEYLPVDALDAAQRAFAG 183
Query: 183 ADAVLVVGTSGLVYPAAYIPYIVKESGGTVIEVNVEESAITPIADFFLRGRAGEVLPRVV 242
A+ LV+GTS +VYPAA + GG VIE+N E + +TP A F LR A L ++
Sbjct: 184 AEVALVIGTSSVVYPAAGLAAETLRRGGAVIEINPEATDLTPDATFSLRESASRGLELLL 243
Query: 243 HE 244
+
Sbjct: 244 ED 245
>gb|AAC78722.1| (U89687) putative nicotinic acid mononucleotide:5,
6-dimethylbenzimidazole(DMB)phosphoribosyltransferase
[Salmonella typhimurium]
Length = 237
Score = 166 bits (417), Expect = 2e-40
Identities = 98/241 (40%), Positives = 141/241 (57%), Gaps = 18/241 (7%)
Query: 9 LASSKNAIAFTGAGISAESGVPTFRGKDGLWNKYRPEELATPEAFARNPKLVWEFYKWRI 68
+ + + TGAGISAESG+ TFR DGLW ++R E++ATPE FARNP LV FY R
Sbjct: 1 MMENPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFARNPGLVQTFYNARR 60
Query: 69 NKIL--KAKPNPAHYALVELED-MGILRAVITQNVDDLHREAGTRNLIELHGNIFRVKCT 125
++ + +PN AH AL L+ + I ++TQN+D+LH AG RN+I++HG + +V+C+
Sbjct: 61 QQLQQPEIQPNAAHLALANLKKRLAIAFLLVTQNIDNLHERAGNRNIIQMHGELLKVRCS 120
Query: 126 KCNFKEYLKESQRLE---EVLKEDLPKCPRCGSLLRPDVVWFGE-PLPREELDRAFKLAE 181
+ Q LE +V+ ED C + + LRP VVWFGE PL +E+ A +
Sbjct: 121 --------QSGQILEWNGDVMPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALSM-- 170
Query: 182 KADAVLVVGTSGLVYPAAYIPYIVKESGGTVIEVNVEESAITPIADFFLRGRAGEVLPRV 241
AD + +GTSG VYPAA + K G +E+N+E S + + G A +V+P
Sbjct: 171 -ADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFEEKHYGPASQVVPEF 229
Query: 242 V 242
V
Sbjct: 230 V 230
>gi|11418990 sir2-like 5 [Homo sapiens]
Length = 247
Score = 161 bits (402), Expect = 1e-38
Identities = 85/198 (42%), Positives = 118/198 (58%), Gaps = 24/198 (12%)
Query: 2 IVEVARVLASSKNAIAFTGAGISAESGVPTFRGKDGLWNKYRPEELATPEAFARNPKLVW 61
+ + + A +K+ + +GAG+SAESGVPTFRG G W K++ ++LATP AFA NP VW
Sbjct: 40 MADFRKFFAKAKHIVIISGAGVSAESGVPTFRGAGGYWRKWQAQDLATPLAFAHNPSRVW 99
Query: 62 EFYKWRINKILKAKPNPAHYALVELED----MGILRAVITQNVDDLHREAGTRNLIELHG 117
EFY +R + +PN H A+ E E G VITQN+D+LHR+AGT+NL+E+HG
Sbjct: 100 EFYHYRREVMGSKEPNAGHRAIAECETRLGKQGRRVVVITQNIDELHRKAGTKNLLEIHG 159
Query: 118 NIFRVKCTKC-----NFKEYL----------KESQRLEEVLKEDLPKCPR--CGSLLRPD 160
++F+ +CT C N+K + + + + E LP+C CG LLRP
Sbjct: 160 SLFKTRCTSCGVVAENYKSPICPALSGKGAPEPGTQDASIPVEKLPRCEEAGCGGLLRPH 219
Query: 161 VVWFGE---PLPREELDR 175
VVWFGE P EE+DR
Sbjct: 220 VVWFGENLDPAILEEVDR 237
>pir||E64856 hypothetical protein b1120 - Escherichia coli
>gi|1787364|gb|AAC74204.1| (AE000212) putative nicotinic
acid mononucleotide:5,6-dimethylbenzimidazole (DMB)
phosphoribosyltransferase [Escherichia coli K12]
>gi|4062692|dbj|BAA35940.1| (D90747) ORF_ID:o238#9
[Escherichia coli]
Length = 279
Score = 160 bits (401), Expect = 1e-38
Identities = 96/242 (39%), Positives = 142/242 (58%), Gaps = 18/242 (7%)
Query: 16 IAFTGAGISAESGVPTFRGKDGLWNKYRPEELATPEAFARNPKLVWEFYKWRINKIL--K 73
+ TGAGISAESG+ TFR DGLW ++R E++ATPE F R+P+LV FY R ++ +
Sbjct: 44 LVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQQPE 103
Query: 74 AKPNPAHYALVELED-MGILRAVITQNVDDLHREAGTRNLIELHGNIFRVKCTKCNFKEY 132
+PN AH AL +L+D +G ++TQN+D+LH AG N+I +HG + +V+C+
Sbjct: 104 IQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCS------- 156
Query: 133 LKESQRLE---EVLKEDLPKCPRCGSLLRPDVVWFGE-PLPREELDRAFKLAEKADAVLV 188
+ Q L+ +V ED C + + LRP VVWFGE PL +E+ A + AD +
Sbjct: 157 -QSGQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALSM---ADIFIA 212
Query: 189 VGTSGLVYPAAYIPYIVKESGGTVIEVNVEESAITPIADFFLRGRAGEVLPRVVHEVRRL 248
+GTSG VYPAA + K G +E+N+E S + G A +V+P V ++ +
Sbjct: 213 IGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKLLKG 272
Query: 249 LQ 250
L+
Sbjct: 273 LK 274
>pir||A83495 hypothetical protein PA1197 [imported] - Pseudomonas aeruginosa
(strain PAO1) >gi|9947124|gb|AAG04586.1|AE004550_2
(AE004550) hypothetical protein [Pseudomonas aeruginosa]
Length = 256
Score = 150 bits (376), Expect = 1e-35
Identities = 99/261 (37%), Positives = 140/261 (52%), Gaps = 26/261 (9%)
Query: 2 IVEVARVLASSKNAIAFTGAGISAESGVPTFRGKDGLWNKYRPEELATPEAFA-----RN 56
I VA+ L ++ + TGAG+SA+SG+PT+RG GL+N E L A + R+
Sbjct: 7 IATVAQALRRAERILVITGAGLSADSGMPTYRGLGGLYNGRTEEGLPIEAALSGPMLRRD 66
Query: 57 PKLVWEFYKWRINKILKAKPNPAHYALVELEDMGILRAVITQNVDDLHREAGT--RNLIE 114
P L W++ L A+PN H A+ EL+ V+TQN+D HR+AG+ LIE
Sbjct: 67 PALCWKYLAELGKACLAARPNAGHEAIAELQKHKPECWVLTQNIDGFHRQAGSPAERLIE 126
Query: 115 LHGNIFRVKCTKCNFKEYLKESQRLEEVLKEDL-PKCPRCGSLLRPDVVWFGEPLPREEL 173
+HG + + C C ES LEE L L P+C CG +LRP VV F E LP E +
Sbjct: 127 IHGELAPLYCQSCG-----AESGGLEEHLHGQLPPRCAACGGVLRPPVVLFEEMLPEEAI 181
Query: 174 DRAFKLAEKA-DAVLVVGTSGLVYPAAYIPYIV------KESGGTVIEVNVEESAITPIA 226
D ++ K DAVLVVGT+ A PYIV +++GG EVN + ++
Sbjct: 182 DTLYRELRKGFDAVLVVGTT------ASFPYIVEPVLRTRQAGGFTAEVNPGVTDLSERV 235
Query: 227 DFFLRGRAGEVLPRVVHEVRR 247
D + GRA +++P+VV + R
Sbjct: 236 DVKMTGRALDIMPQVVSHIYR 256
>dbj|BAB04626.1| (AP001510) transcriptional regulator [Bacillus halodurans]
Length = 237
Score = 144 bits (360), Expect = 9e-34
Identities = 86/242 (35%), Positives = 129/242 (52%), Gaps = 11/242 (4%)
Query: 9 LASSKNAIAFTGAGISAESGVPTFRGKDGLWNKYRPEELATPEAFARNPKLVWEFYKWRI 68
L +K + FTGAG+S ESGVP FR GLW PE LA+ +A N + +FY+ RI
Sbjct: 6 LTEAKKIVIFTGAGMSTESGVPDFRSSRGLWQGKNPEALASVDAMDHNREAFIDFYRMRI 65
Query: 69 NKILKAKPNPAHYALVELEDMGILRAVITQNVDDLHREAGTRNLIELHGNIFRVKCTKCN 128
+ +P+ + L E + ++ITQN D LH +AG+ ++ LHG+I R+ C C
Sbjct: 66 EGLQGVRPHKGYDVLAAWEKELPITSIITQNTDGLHEQAGSEVVLPLHGSIQRLYCVACG 125
Query: 129 FKEYLKESQRLEEVLKEDLPKCPRCGSLLRPDVVWFGEPLPREELDRAFKLAEKADAVLV 188
+ + E P C CG +RP VV FGE L + L A + ++AD LV
Sbjct: 126 QRYDVARYITNE-------PYC-SCGGFIRPAVVLFGEMLNTDTLALAERHTKEADLFLV 177
Query: 189 VGTSGLVYPAAYIPYIVKESGGTVIEVNVEESAITPIADFFLRGRAGEVLPRVVHEVRRL 248
+G+S +V PA P I KE G ++ VN +E+ + P+AD ++ ++ + + E R
Sbjct: 178 LGSSLVVSPANLFPKIAKECGAKLVIVNHDETPLDPLADLVIQDQS---IGTFLEETNRA 234
Query: 249 LQ 250
LQ
Sbjct: 235 LQ 236
>dbj|BAB09243.1| (AB009050) transcription regulator Sir2-like protein [Arabidopsis
thaliana]
Length = 473
Score = 137 bits (342), Expect = 1e-31
Identities = 89/248 (35%), Positives = 133/248 (52%), Gaps = 21/248 (8%)
Query: 2 IVEVARVLASSKNAIAFTGAGISAESGVPTFRGKDGLWNKYRPEELATPEAFARNPKLVW 61
I E+A+++ SK+ + FTGAGIS G+P FRG G+W R + PK
Sbjct: 34 IEELAKLIQKSKHLVVFTGAGISTSCGIPDFRGPKGIWTLQREGKDL--------PKASL 85
Query: 62 EFYKWRINKILKAKPNPAHYALVELEDMGILRAVITQNVDDLHREAGT--RNLIELHGNI 119
F++ A P+ H ALVELE GIL+ VI+QNVD LH +G L ELHG+
Sbjct: 86 PFHR--------AMPSMTHMALVELERAGILKFVISQNVDGLHLRSGIPREKLSELHGDS 137
Query: 120 FRVKCTKCNFKEYLKESQRLEEVLKEDLPKCP--RCGSLLRPDVVWFGEPLPREELDRAF 177
F C C EYL++ + LKE KC +CG+ L+ V+ + + LP +E+D A
Sbjct: 138 FMEMCPSCG-AEYLRDFEVETIGLKETSRKCSVEKCGAKLKDTVLDWEDALPPKEIDPAE 196
Query: 178 KLAEKADAVLVVGTSGLVYPAAYIPYIVKESGGTVIEVNVEESAITPIADFFLRGRAGEV 237
K +KAD VL +GTS + PA +P + GG ++ VN++++ A+ + G +V
Sbjct: 197 KHCKKADLVLCLGTSLQITPACNLPLKCLKGGGKIVIVNLQKTPKDKKANVVIHGLVDKV 256
Query: 238 LPRVVHEV 245
+ V+ +
Sbjct: 257 VAGVMESL 264
>gb|AAC70895.1| (AF006830) unknown [Actinobacillus actinomycetemcomitans]
Length = 208
Score = 136 bits (339), Expect = 3e-31
Identities = 81/183 (44%), Positives = 110/183 (59%), Gaps = 10/183 (5%)
Query: 16 IAFTGAGISAESGVPTFRGKDGLWNKYRPEELATPEAFARNPKLVWEFYKWRINKILKAK 75
+ +GAGISAESG+PT+R +DGLW ++ E++ TPEA RN K V FY R +AK
Sbjct: 6 VVLSGAGISAESGIPTYRAEDGLWAGHKIEDVCTPEALQRNRKQVLAFYNERRRNCAEAK 65
Query: 76 PNPAHYALVELEDMGILRAVITQNVDDLHREAGTRNLIELHGNIFRVKCTKCNFKEYLKE 135
PN AH LVELE ++ +ITQNV+DLH AG+ N++ LHG + K +Y+
Sbjct: 66 PNAAHKVLVELERSYNVQ-IITQNVEDLHERAGSTNVLHLHGEL--TKARSSFDPDYIVP 122
Query: 136 SQRLEEVLKEDLPKCPRCGSLLRPDVVWFGEPLPREELDRAFKLAEKADAVLVVGTSGLV 195
+ V +D P G +RP +V+FGE +P L+ A L +AD VLV+GTS V
Sbjct: 123 CMGDQSVNDKD-PN----GHPMRPHIVFFGESVP--VLEPAIDLVSQADIVLVIGTSLQV 175
Query: 196 YPA 198
YPA
Sbjct: 176 YPA 178
>pir||A71838 hypothetical protein jhp1180 - Helicobacter pylori (strain J99)
>gi|4155790|gb|AAD06766.1| (AE001545) putative
[Helicobacter pylori J99]
Length = 234
Score = 131 bits (327), Expect = 7e-30
Identities = 76/187 (40%), Positives = 106/187 (56%), Gaps = 10/187 (5%)
Query: 13 KNAIAFTGAGISAESGVPTFRGKDGLWNKYRPEELATPEAFARNPKLVWEFYKWRINKIL 72
KN + +GAGISAESG+ TFR GLW + E+A+P + +NP+ V +FY R ++
Sbjct: 2 KNLVILSGAGISAESGIKTFRDAGGLWEGHDIMEVASPYGWKKNPQKVLDFYNQRRRQLF 61
Query: 73 KAKPNPAHYALVELEDMGILRAVITQNVDDLHREAGTRNLIELHGNIFRVKCTKCNFKEY 132
+ PN AH AL ELE + +ITQNVDDLH AG+ ++ LHG + V+ K Y
Sbjct: 62 EVYPNKAHKALAELEKHYQVN-IITQNVDDLHERAGSSRILHLHGELLSVRSEKDPNLVY 120
Query: 133 LKESQRLEEVLKEDLPKCPRCGSLLRPDVVWFGEPLPREELDRAFKLAEKADAVLVVGTS 192
E L +D + LRPD+VWFGE +P L A L ++ ++++GTS
Sbjct: 121 RWEKDLNLGDLAQDKAQ-------LRPDIVWFGEEVPL--LKEAVSLVKQVHLLIIIGTS 171
Query: 193 GLVYPAA 199
VYPAA
Sbjct: 172 LQVYPAA 178
>gb|AAD42226.1|AF159133_1 (AF159133) SIR2-like protein [Oryza sativa subsp. indica]
Length = 483
Score = 129 bits (322), Expect = 3e-29
Identities = 87/246 (35%), Positives = 127/246 (51%), Gaps = 21/246 (8%)
Query: 2 IVEVARVLASSKNAIAFTGAGISAESGVPTFRGKDGLWNKYRPEELATPEAFARNPKLVW 61
I E+A ++ SK+ + FTGA IS SG+P FRG G+W R + P A
Sbjct: 34 IEELAVMVRESKHLVVFTGASISTSSGIPDFRGPKGVWTLQRSGK-GVPGATL------- 85
Query: 62 EFYKWRINKILKAKPNPAHYALVELEDMGILRAVITQNVDDLHREAGT--RNLIELHGNI 119
+A P H ALVELE G L+ VI+QNVD LH +G L ELHGN
Sbjct: 86 --------PFQRAVPTLTHMALVELEKTGRLKFVISQNVDSLHLRSGLPREKLAELHGNS 137
Query: 120 FRVKCTKCNFKEYLKESQRLEEVLKEDLPKCP--RCGSLLRPDVVWFGEPLPREELDRAF 177
F+ C C KEYL++ + LK+ +C CG+ L+ V+ + + LP EE+D A
Sbjct: 138 FKEICPSCK-KEYLRDFEIETIGLKDTPRRCSDKNCGARLKDTVLDWEDALPPEEMDAAK 196
Query: 178 KLAEKADAVLVVGTSGLVYPAAYIPYIVKESGGTVIEVNVEESAITPIADFFLRGRAGEV 237
+ + AD VL +GTS + PA +P + ++GG V VN++ + A + G +V
Sbjct: 197 EQCQTADLVLCLGTSLQITPACNMPLLSLKNGGRVAIVNLQATPKDKKASLVIHGLVDKV 256
Query: 238 LPRVVH 243
+ V++
Sbjct: 257 IAGVMY 262
>emb|CAC05449.1| (AL391712) SIR2-family protein [Arabidopsis thaliana]
Length = 451
Score = 124 bits (309), Expect = 9e-28
Identities = 83/287 (28%), Positives = 138/287 (47%), Gaps = 49/287 (17%)
Query: 2 IVEVARVLASSKNAIAFTGAGISAESGVPTFRGKDGLWNK-YRP--EELATPEAFARNPK 58
I ++ R+ S TGAG+S E G+P +R +G ++ ++P + T + AR
Sbjct: 158 IHKLYRLFEQSSRLTILTGAGVSTECGIPDYRSPNGAYSSGFKPITHQEFTRSSRARRRY 217
Query: 59 LVWEFYKWRINKILKAKPNPAHYALVELEDMGILRAVITQNVDDLHREAGTRNLIELHGN 118
+ WR + A+P PAH AL LE G + +ITQNVD LH AG+ + +ELHG
Sbjct: 218 WARSYAGWR--RFTAAQPGPAHTALASLEKAGRINFMITQNVDRLHHRAGS-DPLELHGT 274
Query: 119 IFRVKCTKCN-------FKEYLKE-------SQRLEEVLKED------------------ 146
++ V C +C F++ LK ++ +E + D
Sbjct: 275 VYTVMCLECGFSFPRDLFQDQLKAINPKASWAEAIESIDHGDPGSEKSFGMKQRPDGDIE 334
Query: 147 -----------LPKCPRCGSLLRPDVVWFGEPLPREELDRAFKLAEKADAVLVVGTSGLV 195
+P C +C +L+PDV++FG+ +P+E +A ++A+++DA LV+G+S +
Sbjct: 335 IDEKFWEEGFHIPVCEKCKGVLKPDVIFFGDNIPKERATQAMEVAKQSDAFLVLGSSLMT 394
Query: 196 YPAAYIPYIVKESGGTVIEVNVEESAITPIADFFLRGRAGEVLPRVV 242
A + E+G VN+ E+ I + R GE+L RV+
Sbjct: 395 MSAFRLCRAAHEAGAMTAIVNIGETRADDIVPLKINARVGEILHRVL 441
>gb|AAD15478.1| (AC006930) R33423_1 [Homo sapiens]
Length = 377
Score = 123 bits (307), Expect = 1e-27
Identities = 86/264 (32%), Positives = 127/264 (47%), Gaps = 42/264 (15%)
Query: 4 EVARVLASSKNAIAFTGAGISAESGVPTFRGKDGLWNKYRPEELATPEAFARNPKLVWEF 63
E+AR++ S + + TGAGIS SG+P FRG G+W T E PK F
Sbjct: 36 ELARLVWQSSSVVFHTGAGISTASGIPDFRGPHGVW---------TMEERGLAPKFDTTF 86
Query: 64 YKWRINKILKAKPNPAHYALVELEDMGILRAVITQNVDDLHREAG--TRNLIELHGNIFR 121
A+P H ALV+LE +G+LR +++QNVD LH +G L ELHGN+F
Sbjct: 87 ES--------ARPTQTHMALVQLERVGLLRFLVSQNVDGLHVRSGFPRDKLAELHGNMFV 138
Query: 122 VKCTKCNFKEY---------LKESQRLEEVLK--------------EDLPKCPRCGSLLR 158
+C KC + LK + RL V K ED P+ P C LR
Sbjct: 139 EECAKCKTQYVRDTVVGTMGLKATGRLCTVAKARGLRACRGGCEAPEDSPQLPHCRGELR 198
Query: 159 PDVVWFGEPLPREELDRAFKLAEKADAVLVVGTSGLVYPAAYIPYIVKESGGTVIEVNVE 218
++ + + LP +L A + + AD + +GTS + P+ +P K GG ++ VN++
Sbjct: 199 DTILDWEDSLPDRDLALADEASRNADLSITLGTSLQIRPSGNLPLATKRRGGRLVIVNLQ 258
Query: 219 ESAITPIADFFLRGRAGEVLPRVV 242
+ AD + G EV+ R++
Sbjct: 259 PTKHDRHADLRIHGYVDEVMTRLM 282
>pir||H69827 conserved hypothetical protein yhdZ - Bacillus subtilis
>gi|2226221|emb|CAA74510.1| (Y14082) hypothetical
protein [Bacillus subtilis] >gi|2633300|emb|CAB12804.1|
(Z99109) similar to hypothetical proteins [Bacillus
subtilis]
Length = 247
Score = 122 bits (302), Expect = 6e-27
Identities = 74/240 (30%), Positives = 124/240 (50%), Gaps = 19/240 (7%)
Query: 8 VLASSKNAIAFTGAGISAESGVPTFRGKDGLWNKYRPE-ELATPEAFARNPKLVWEFYK- 65
+L ++ + TGAG+S ESG+P FR G+W + E + + F P+L W +K
Sbjct: 7 ILHEAQRIVVLTGAGMSTESGIPDFRSAGGIWTEDASRMEAMSLDYFLSYPRLFWPKFKE 66
Query: 66 -WRINKILKAKPNPAHYALVELEDMGILRAVITQNVDDLHREAGTRNLIELHGNIFRVKC 124
+++ +PN H L ELE G + TQN+D LH++AG+R++ ELHG+I C
Sbjct: 67 LFQMKMSGSFEPNEGHLLLAELEKQGKQVDIFTQNIDGLHKKAGSRHVYELHGSIQTAAC 126
Query: 125 TKCNFKEYLKESQRLEEVLKEDLPKCPR-------CGSLLRPDVVWFGEPLPREELDRAF 177
C + L +L+ ++P+C CG++L+ DVV FG+ + D +
Sbjct: 127 PACGAR------YDLPHLLEREVPECTAAGNNGDICGTVLKTDVVLFGDAV--MHFDTLY 178
Query: 178 KLAEKADAVLVVGTSGLVYPAAYIPYIVK-ESGGTVIEVNVEESAITPIADFFLRGRAGE 236
+ ++AD +LV+GTS V PA ++P G + +N+E + + D + + GE
Sbjct: 179 EKLDQADLLLVIGTSLEVAPARFVPEDASLIPGMKKVIINLEPTYCDSLFDMVIHQKIGE 238
>gi|6912662 sir2-like 4; sirtuin type 4 [Homo sapiens]
>gi|11436610|ref|XP_007029.1| sir2-like 4 [Homo sapiens]
>gi|5225324|gb|AAD40852.1|AF083109_1 (AF083109) sirtuin
type 4 [Homo sapiens]
Length = 314
Score = 121 bits (300), Expect = 1e-26
Identities = 88/270 (32%), Positives = 133/270 (48%), Gaps = 32/270 (11%)
Query: 2 IVEVARVLASSKNAIAFTGAGISAESGVPTFRG-KDGLWNKY--RPEELATPEAFARNPK 58
+ E+ R + SK + TGAGIS ESG+P +R K GL+ + RP + A +
Sbjct: 44 VKELQRFITLSKRLLVMTGAGISTESGIPDYRSEKVGLYARTDRRPIQHGDFVRSAPIRQ 103
Query: 59 LVW--EFYKWRINKILKAKPNPAHYALVELEDMGILRAVITQNVDDLHREAGTRNLIELH 116
W F W + +PNPAH+AL E +G L ++TQNVD LH +AG+R L ELH
Sbjct: 104 RYWARNFVGWP--QFSSHQPNPAHWALSTWEKLGKLYWLVTQNVDALHTKAGSRRLTELH 161
Query: 117 GNIFRVKCTKCNF---KEYLKESQRL----------------------EEVLKEDLPKCP 151
G + RV C C + L+E ++ E+V +P C
Sbjct: 162 GCMDRVLCLDCGEQTPRGVLQERFQVLNPTWSAEAHGLAPDGDVFLSEEQVRSFQVPTCV 221
Query: 152 RCGSLLRPDVVWFGEPLPREELDRAFKLAEKADAVLVVGTSGLVYPAAYIPYIVKESGGT 211
+CG L+PDVV+FG+ + +++D K ++AD++LVVG+S VY E
Sbjct: 222 QCGGHLKPDVVFFGDTVNPDKVDFVHKRVKEADSLLVVGSSLQVYSGYRFILTAWEKKLP 281
Query: 212 VIEVNVEESAITPIADFFLRGRAGEVLPRV 241
+ +N+ + +A L R GE+LP +
Sbjct: 282 IAILNIGPTRSDDLACLKLNSRCGELLPLI 311
>pir||T24172 hypothetical protein R11A8.4 - Caenorhabditis elegans
>gi|3879115|emb|CAA94364.1| (Z70310) predicted using
Genefinder~Similarity to K.lactis regulatory protein
SIR2 (SW:SIR2_KLULA), contains similarity to Pfam
domain: PF02146 (Sir2 family), Score=372.6,
E-value=1.3e-108, N=1~cDNA EST EMBL:Z14446 comes from
this gene~cDNA EST yk352g2>
Length = 607
Score = 118 bits (292), Expect = 8e-26
Identities = 77/247 (31%), Positives = 126/247 (50%), Gaps = 18/247 (7%)
Query: 2 IVEVARVLASSKNAIAFTGAGISAESGVPTFRGKDGLWNKYRPE--ELATPEA------F 53
+ + + + K+ + TGAG+S G+P FR KDG++ + R E +L P A F
Sbjct: 135 LADAVELFKTKKHILVLTGAGVSVSCGIPDFRSKDGIYARLRSEFPDLPDPTAMFDIRYF 194
Query: 54 ARNPKLVWEFYKWRINKILKAK--PNPAHYALVELEDMGILRAVITQNVDDLHREAGTRN 111
NP + F + +I + P+ +H + ELE G L TQN+D L + G +
Sbjct: 195 RENPAPFYNFAR----EIFPGQFVPSVSHRFIKELETSGRLLRNYTQNIDTLEHQTGIKR 250
Query: 112 LIELHGNIFRVKCTKCNFKEYLKESQRLEEVLKEDLPKCPRCGSLLRPDVVWFGEPLPRE 171
++E HG+ + CT+C K E + EEVL + C RC +++P++V+FGE L RE
Sbjct: 251 VVECHGSFSKCTCTRCGQKYDGNEIR--EEVLAMRVAHCKRCEGVIKPNIVFFGEDLGRE 308
Query: 172 ELDRAFKLAEKADAVLVVGTSGLVYPAAYIPYIVKESGGTVIEVNVEESAITPIADFFLR 231
+ K D ++V+G+S V P A IP+ V ++ ++ +N ES AD L
Sbjct: 309 FHQHVTEDKHKVDLIVVIGSSLKVRPVALIPHCVDKNVPQIL-IN-RESLPHYNADIELL 366
Query: 232 GRAGEVL 238
G +++
Sbjct: 367 GNCDDII 373
>gi|7706710 sir2-related protein type 6; sirtuin type 6 [Homo sapiens]
>gi|7243749|gb|AAF43432.1|AF233396_1 (AF233396)
sir2-related protein type 6 [Homo sapiens]
Length = 355
Score = 116 bits (289), Expect = 2e-25
Identities = 82/253 (32%), Positives = 124/253 (48%), Gaps = 30/253 (11%)
Query: 4 EVARVLASSKNAIAFTGAGISAESGVPTFRGKDGLWNKYRPEELATPEAFARNPKLVWEF 63
E+AR++ S + + TGAGIS SG+P FRG G+W T E PK F
Sbjct: 36 ELARLVWQSSSVVFHTGAGISTASGIPDFRGPHGVW---------TMEERGLAPKFDTTF 86
Query: 64 YKWRINKILKAKPNPAHYALVELEDMGILRAVITQNVDDLHREAG--TRNLIELHGNIFR 121
A+P H ALV+LE +G+LR +++QNVD LH +G L ELHGN+F
Sbjct: 87 ES--------ARPTQTHMALVQLERVGLLRFLVSQNVDGLHVRSGFPRDKLAELHGNMFV 138
Query: 122 VKCTKCNFKEY---------LKESQRLEEVLKEDLPKCPRCGSLLRPDVVWFGEPLPREE 172
+C KC + LK + RL V K + C LR ++ + + LP +
Sbjct: 139 EECAKCKTQYVRDTVVGTMGLKATGRLCTVAKARGLRA--CRGELRDTILDWEDSLPDRD 196
Query: 173 LDRAFKLAEKADAVLVVGTSGLVYPAAYIPYIVKESGGTVIEVNVEESAITPIADFFLRG 232
L A + + AD + +GTS + P+ +P K GG ++ VN++ + AD + G
Sbjct: 197 LALADEASRNADLSITLGTSLQIRPSGNLPLATKRRGGRLVIVNLQPTKHDRHADLRIHG 256
Query: 233 RAGEVLPRVVHEV 245
EV+ R++ +
Sbjct: 257 YVDEVMTRLMEHL 269
>gi|11425892 sir2-related protein type 6 [Homo sapiens]
Length = 375
Score = 115 bits (286), Expect = 4e-25
Identities = 83/250 (33%), Positives = 122/250 (48%), Gaps = 30/250 (12%)
Query: 4 EVARVLASSKNAIAFTGAGISAESGVPTFRGKDGLWNKYRPEELATPEAFARNPKLVWEF 63
E+AR++ S N + TGAGIS SG TFRG G+W T E PK F
Sbjct: 56 ELARLVWQSSNVVFHTGAGISTASGPATFRGPHGVW---------TMEERGLAPKFDTTF 106
Query: 64 YKWRINKILKAKPNPAHYALVELEDMGILRAVITQNVDDLHREAG--TRNLIELHGNIFR 121
A+P H ALV+LE +G+LR +++QNVD LH +G L ELHGN+F
Sbjct: 107 ES--------ARPTQTHMALVQLERVGLLRFLVSQNVDGLHVRSGFPRDKLAELHGNMFV 158
Query: 122 VKCTKCNFKEY---------LKESQRLEEVLKEDLPKCPRCGSLLRPDVVWFGEPLPREE 172
+C KC + LK + RL V K + C LR ++ + + LP +
Sbjct: 159 EECAKCKTQYVRDTVVGTMGLKATGRLCTVAKARGLRA--CRGELRDTILDWEDSLPDRD 216
Query: 173 LDRAFKLAEKADAVLVVGTSGLVYPAAYIPYIVKESGGTVIEVNVEESAITPIADFFLRG 232
L A + + AD + +GTS + P+ +P K GG ++ VN++ + AD + G
Sbjct: 217 LALADEASRNADLSITLGTSLQIRPSGNLPLATKRRGGRLVIVNLQPTKHDRHADLRIHG 276
Query: 233 RAGEVLPRVV 242
EV+ R++
Sbjct: 277 YVDEVMTRLM 286
>gb|AAA67853.1| (M32103) ORF-27 [Staphylococcus aureus]
Length = 243
Score = 115 bits (284), Expect = 7e-25
Identities = 75/218 (34%), Positives = 114/218 (51%), Gaps = 14/218 (6%)
Query: 8 VLASSKNAIAFTGAGISAESGVPTFRGKDGLWNKYR-----PEELATPEAFARNPKLVWE 62
++ SS FTGAG+S SGVP FR GL+++ PE L + + +P+
Sbjct: 11 IIDSSNRITFFTGAGVSVASGVPDFRSMGGLFDEISKDGLSPEYLLSRDYLEDDPEGFIN 70
Query: 63 FYKWRINKILKAKPNPAHYALVELEDMGILRAVITQNVDDLHREAGTRNLIELHGNIFRV 122
F R+ + PN H + +LE VITQN+D LH +AG++++ ELHG + R
Sbjct: 71 FCHKRL-LFVDTMPNIVHDWIAKLERNQQSLGVITQNIDGLHSDAGSQHVDELHGTLNRF 129
Query: 123 KCTKCNFKEYLKESQRLEEVLKEDLPKCPRCGSLLRPDVVWFGEPLPREELDRAFKLAEK 182
C C+ K Y K +V+ L C CG +RPD+V +GE L + + RA E
Sbjct: 130 YCNVCH-KSYTKS-----DVIDRTLKHCDNCGGAIRPDIVLYGEMLDQPTIIRALNKIEH 183
Query: 183 ADAVLVVGTSGLVYPAAYIPYIVKESGGTVIEVNVEES 220
AD ++V+G+S +V PAA + I G +I +N + +
Sbjct: 184 ADTLVVLGSSLVVQPAAGL--ISHFKGDNLIIINKDRT 219
>gi|6912660 sir2-like 3; sirtuin type 3 [Homo sapiens]
>gi|5225322|gb|AAD40851.1|AF083108_1 (AF083108) sirtuin
type 3 [Homo sapiens]
Length = 399
Score = 115 bits (284), Expect = 7e-25
Identities = 89/262 (33%), Positives = 128/262 (47%), Gaps = 27/262 (10%)
Query: 2 IVEVARVLASSKNAIAFTGAGISAESGVPTFRGK-DGLWNKYRPEELATPEA------FA 54
+ E+ R A + + GAGIS SG+P FR GL++ + +L PEA F
Sbjct: 128 VAELIRARACQR-VVVMVGAGISTPSGIPDFRSPGSGLYSNLQQYDLPYPEAIFELPFFF 186
Query: 55 RNPK----LVWEFYKWRINKILKAKPNPAHYALVELEDMGILRAVITQNVDDLHREAG-- 108
NPK L E Y KPN HY L L D G+L + TQN+D L R +G
Sbjct: 187 HNPKPFFTLAKELYPGNY------KPNVTHYFLRLLHDKGLLLRLYTQNIDGLERVSGIP 240
Query: 109 TRNLIELHGNIFRVKCTKCNFKEYLKESQRLEEVLKEDLPKCPRCGSLLRPDVVWFGEPL 168
L+E HG CT C + + E R + V+ + +P+CP C +++PD+V+FGEPL
Sbjct: 241 ASKLVEAHGTFASATCTVCQ-RPFPGEDIRAD-VMADRVPRCPVCTGVVKPDIVFFGEPL 298
Query: 169 PREELDRAFKLAEKADAVLVVGTSGLVYPAAYIPYIVKESGGTVIEVNVEESAITPIADF 228
P+ L AD +L++GTS V P A + V+ S V + + + P+A +
Sbjct: 299 PQRFLLHVVDF-PMADLLLILGTSLEVEPFASLTEAVRSS---VPRLLINRDLVGPLA-W 353
Query: 229 FLRGRAGEVLPRVVHEVRRLLQ 250
R R L VVH V L++
Sbjct: 354 HPRSRDVAQLGDVVHGVESLVE 375
>pir||G81307 probable transferase Cj1050c [imported] - Campylobacter jejuni
(strain NCTC 11168) >gi|6968486|emb|CAB73306.1|
(AL139077) putative transferase [Campylobacter jejuni]
Length = 233
Score = 114 bits (282), Expect = 1e-24
Identities = 71/207 (34%), Positives = 108/207 (51%), Gaps = 11/207 (5%)
Query: 13 KNAIAFTGAGISAESGVPTFRGKDGLWNKYRPEELATPEAFARNPKLVWEFYKWRINKIL 72
KN + +GAG+SA SG+ TFR DGLW +Y E+ + F +NPK V +FY R ++
Sbjct: 2 KNIMILSGAGLSAPSGLKTFRDNDGLWEEYDVMEVCSATGFRKNPKKVLDFYDARRAQLQ 61
Query: 73 KAKPNPAHYALVEL-EDMGILRAVITQNVDDLHREAGTRNLIELHGNIFRVKCTKCNFKE 131
KPN AH + +L E G VITQNVDDL AG ++++ LHG + ++C KC
Sbjct: 62 NVKPNHAHEKIAQLKEKWGKNLFVITQNVDDLLERAGCKDVVHLHGFLPELRCLKCEGIF 121
Query: 132 YLKESQRLEEVLKEDLPKCPRCGSL-LRPDVVWFGEPLPREELDRAFKLAEKADAVLVVG 190
+ + ++ +CP+C S LR ++V F E P + L + + +G
Sbjct: 122 NIGYEKFTDK-------QCPKCKSKDLRHNIVMFEEQAP--AYATLYSLLHQTSLFISIG 172
Query: 191 TSGLVYPAAYIPYIVKESGGTVIEVNV 217
TSG V P + ++S + E +V
Sbjct: 173 TSGAVLPVGQYASMCEKSILNIYEKDV 199
>gb|AAB95634.1| (AC003982) unknown function; 60% similar to Z50177 (PID:g927403)
(PID:g927402) [Homo sapiens]
Length = 326
Score = 113 bits (281), Expect = 2e-24
Identities = 87/282 (30%), Positives = 133/282 (46%), Gaps = 44/282 (15%)
Query: 2 IVEVARVLASSKNAIAFTGAGISAESGVPTFRG-KDGLWNKY--RPEELATPEAFARNPK 58
+ E+ R + SK + TGAGIS ESG+P +R K GL+ + RP + A +
Sbjct: 44 VKELQRFITLSKRLLVMTGAGISTESGIPDYRSEKVGLYARTDRRPIQHGDFVRSAPIRQ 103
Query: 59 LVW--EFYKWRINKILKAKPNPAHYALVELEDMGILRAVITQNVDDLHREAGTRNLIELH 116
W F W + +PNPAH+AL E +G L ++TQNVD LH +AG+R L ELH
Sbjct: 104 RYWARNFVGWP--QFSSHQPNPAHWALSTWEKLGKLYWLVTQNVDALHTKAGSRRLTELH 161
Query: 117 GNIFRVKCTKCNF---------------KEYLKESQRL---------------------- 139
G + R C+ F + L+E ++
Sbjct: 162 GCMDRAYCSVSVFLGSRVLCLDCGEQTPRGVLQERFQVLNPTWSAEAHGLAPDGDVFLSE 221
Query: 140 EEVLKEDLPKCPRCGSLLRPDVVWFGEPLPREELDRAFKLAEKADAVLVVGTSGLVYPAA 199
E+V +P C +CG L+PDVV+FG+ + +++D K ++AD++LVVG+S VY
Sbjct: 222 EQVRSFQVPTCVQCGGHLKPDVVFFGDTVNPDKVDFVHKRVKEADSLLVVGSSLQVYSGY 281
Query: 200 YIPYIVKESGGTVIEVNVEESAITPIADFFLRGRAGEVLPRV 241
E + +N+ + +A L R GE+LP +
Sbjct: 282 RFILTAWEKKLPIAILNIGPTRSDDLACLKLNSRCGELLPLI 323
>gi|11441548 sir2-like 3 [Homo sapiens]
Length = 433
Score = 113 bits (279), Expect = 3e-24
Identities = 88/262 (33%), Positives = 127/262 (47%), Gaps = 27/262 (10%)
Query: 2 IVEVARVLASSKNAIAFTGAGISAESGVPTFRGK-DGLWNKYRPEELATPEA------FA 54
+ E+ R A + + GAGIS SG+P FR GL++ + +L PEA F
Sbjct: 162 VAELIRARACQR-VVVMVGAGISTPSGIPDFRSPGSGLYSNLQQYDLPYPEAIFELPFFF 220
Query: 55 RNPK----LVWEFYKWRINKILKAKPNPAHYALVELEDMGILRAVITQNVDDLHREAG-- 108
NPK L E Y KPN HY L L D G+L + TQN+D L R +G
Sbjct: 221 HNPKPFFTLAKELYPGNY------KPNVTHYFLRLLHDKGLLLRLYTQNIDGLERVSGIP 274
Query: 109 TRNLIELHGNIFRVKCTKCNFKEYLKESQRLEEVLKEDLPKCPRCGSLLRPDVVWFGEPL 168
L+E HG CT C + + E R + V+ + +P+CP C +++PD+V+FGEPL
Sbjct: 275 ASKLVEAHGTFASATCTVCQ-RPFPGEDIRAD-VMADRVPRCPVCTGVVKPDIVFFGEPL 332
Query: 169 PREELDRAFKLAEKADAVLVVGTSGLVYPAAYIPYIVKESGGTVIEVNVEESAITPIADF 228
P+ L AD +L++G S V P A + V+ S V + + + P+A +
Sbjct: 333 PQRFLLHVVDF-PMADLLLILGNSLEVEPFASLTEAVRSS---VPRLLINRDLVGPLA-W 387
Query: 229 FLRGRAGEVLPRVVHEVRRLLQ 250
R R L VVH V L++
Sbjct: 388 HPRSRDVAQLGDVVHGVESLVE 409
>gb|AAF77189.1|AF264911_5 (AF264911) putative transferase [Campylobacter jejuni]
Length = 227
Score = 111 bits (276), Expect = 6e-24
Identities = 69/198 (34%), Positives = 103/198 (51%), Gaps = 11/198 (5%)
Query: 13 KNAIAFTGAGISAESGVPTFRGKDGLWNKYRPEELATPEAFARNPKLVWEFYKWRINKIL 72
KN + +G +SA SG+ TFR DGLW +Y E+ + F +NPK V +FY R ++
Sbjct: 2 KNIMILSGRDLSAPSGLKTFRDNDGLWEEYDVMEVCSATGFRKNPKKVLDFYDARRAQLQ 61
Query: 73 KAKPNPAHYALVEL-EDMGILRAVITQNVDDLHREAGTRNLIELHGNIFRVKCTKCNFKE 131
KPN AH + +L E G VITQNVDDL AG ++++ LHG + ++C KC
Sbjct: 62 NVKPNHAHEKIAQLKEKWGKNLFVITQNVDDLLERAGCKDVVHLHGFLPELRCLKCEGIF 121
Query: 132 YLKESQRLEEVLKEDLPKCPRCGSL-LRPDVVWFGEPLPREELDRAFKLAEKADAVLVVG 190
+ + ++ +CP+C S LR ++V F E P + L + + VG
Sbjct: 122 NIGYEKITDK-------QCPKCKSKDLRHNIVMFEEQAP--AYATLYSLLNQTSLFISVG 172
Query: 191 TSGLVYPAAYIPYIVKES 208
TSG V P P + ++S
Sbjct: 173 TSGAVLPVGRYPSMCEKS 190
>emb|CAB56682.1| (AL121596) putative SIR2-like regulatory protein [Streptomyces
coelicolor A3(2)]
Length = 299
Score = 110 bits (272), Expect = 2e-23
Identities = 73/231 (31%), Positives = 113/231 (48%), Gaps = 35/231 (15%)
Query: 16 IAFTGAGISAESGVPTFRGKDGLWNKYRPEELATPEAFARNPKLVWEFYK-----WRINK 70
+ +GAGIS ESG+P +RG+ G +++ P T + F +P+ ++ WR
Sbjct: 35 LVLSGAGISTESGIPDYRGEGGSLSRHTP---MTYQDFTAHPEARRRYWARSHLGWRT-- 89
Query: 71 ILKAKPNPAHYALVELEDMGILRAVITQNVDDLHREAGTRNLIELHGNIFRVKCTKCNFK 130
+A+PN H ++ G+L VITQNVD LH+ AG+ ++ELHG++ RV C C
Sbjct: 90 FGRARPNAGHRSVAAFGRHGLLTGVITQNVDGLHQAAGSEGVVELHGSLDRVVCLSCGVL 149
Query: 131 EYLKE-SQRLEEVLKEDLP------------------------KCPRCGSLLRPDVVWFG 165
+E ++RLEE P C CG +L+PDVV+FG
Sbjct: 150 SPRRELARRLEEANAGFSPVAAGINPDGDADLTDEQVGDFRVVPCAVCGGVLKPDVVFFG 209
Query: 166 EPLPREELDRAFKLAEKADAVLVVGTSGLVYPAAYIPYIVKESGGTVIEVN 216
E +P ++ +L A ++LV+G+S V E+G V+ VN
Sbjct: 210 ENVPPRRVEHCRELVRGASSLLVLGSSLTVMSGLRFVRQAAEAGKPVLIVN 260
>gb|AAC79684.1| (AF068758) SIR2 [Drosophila melanogaster]
Length = 823
Score = 107 bits (264), Expect = 2e-22
Identities = 73/275 (26%), Positives = 127/275 (45%), Gaps = 38/275 (13%)
Query: 4 EVARVLASSKNAIAFTGAGISAESGVPTFRGKDGLWNKYRPE--ELATPEA------FAR 55
+V ++ S+ I TGAG+S G+P FR +G++ + + +L P+A F R
Sbjct: 211 DVISLVKKSQKIIVLTGAGVSVSCGIPDFRSTNGIYARLAHDFPDLPDPQAMFDINYFKR 270
Query: 56 NPKLVWEFYKWRINKILKAKPNPAHYALVELEDMGILRAVITQNVDDLHREAGTRNLIEL 115
+P+ ++F + + +P+P H + LE G L TQN+D L R AG + +IE
Sbjct: 271 DPRPFYKFAREIYPGEFQFQPSPCHRFIKMLETKGKLLRNYTQNIDTLERVAGIQRVIEC 330
Query: 116 HGNIFRVKCTKCNFKEYLKESQRLEEVLKEDLPKCPRC---------------------- 153
HG+ CTKC FK ++ + +P CP+C
Sbjct: 331 HGSFSTASCTKCRFK--CNADALRADIFAQRIPVCPQCQPNKEQSVDASVAVTEEELRQL 388
Query: 154 --GSLLRPDVVWFGEPLPREELDRAFKLAEKADAVLVVGTSGLVYPAAYIPYIVKESGGT 211
+++PD+V+FGE LP E + D ++V+G+S V P A+IP + T
Sbjct: 389 VENGIMKPDIVFFGEGLPDEYHTVMATDKDVCDLLIVIGSSLKVRPVAHIPSSIP---AT 445
Query: 212 VIEVNVEESAITPIA-DFFLRGRAGEVLPRVVHEV 245
V ++ + + + D L G + ++ ++ H +
Sbjct: 446 VPQILINREQLHHLKFDVELLGDSDVIINQICHRL 480
>gi|6912656 SIR2 (silent mating type information regulation 2, S.cerevisiae,
homolog)-like; silencing information regulator 2-like;
SIR2 (silent mating type information regulation 2,
S.cerevisiae,homolog)-like; sirtuin type 2 [Homo
sapiens] >gi|5225320|gb|AAD40850.1|AF083107_1 (AF083107)
sirtuin type 2 [Homo sapiens]
Length = 373
Score = 103 bits (255), Expect = 2e-21
Identities = 73/210 (34%), Positives = 100/210 (46%), Gaps = 21/210 (10%)
Query: 5 VARVLASSK--NAIAFTGAGISAESGVPTFRGKD-GLWNKYRPEELATPEA------FAR 55
VAR + S + I GAGIS +G+P FR GL++ L PEA F +
Sbjct: 51 VARYMQSERCRRVICLVGAGISTSAGIPDFRSPSTGLYDNLEKYHLPYPEAIFEISYFKK 110
Query: 56 NPK----LVWEFYKWRINKILKAKPNPAHYALVELEDMGILRAVITQNVDDLHREAGTR- 110
+P+ L E Y + KP HY + L+D G+L TQN+D L R AG
Sbjct: 111 HPEPFFALAKELYPGQF------KPTICHYFMRLLKDKGLLLRCYTQNIDTLERIAGLEQ 164
Query: 111 -NLIELHGNIFRVKCTKCNFKEYLKESQRLEEVLKEDLPKCPRCGSLLRPDVVWFGEPLP 169
+L+E HG + C + + S E++ E PKC C SL++PD+V+FGE LP
Sbjct: 165 EDLVEAHGTFYTSHCVSASCRHEYPLSWMKEKIFSEVTPKCEDCQSLVKPDIVFFGESLP 224
Query: 170 REELDRAFKLAEKADAVLVVGTSGLVYPAA 199
K D +LV+GTS V P A
Sbjct: 225 ARFFSCMQSDFLKVDLLLVMGTSLQVQPFA 254
>gb|AAD45971.1|AF095714_1 (AF095714) silencing information regulator 2-like protein [Homo
sapiens]
Length = 352
Score = 103 bits (255), Expect = 2e-21
Identities = 73/210 (34%), Positives = 100/210 (46%), Gaps = 21/210 (10%)
Query: 5 VARVLASSK--NAIAFTGAGISAESGVPTFRGKD-GLWNKYRPEELATPEA------FAR 55
VAR + S + I GAGIS +G+P FR GL++ L PEA F +
Sbjct: 30 VARYMQSERCRRVICLVGAGISTSAGIPDFRSPSTGLYDNLEKYHLPYPEAIFEISYFKK 89
Query: 56 NPK----LVWEFYKWRINKILKAKPNPAHYALVELEDMGILRAVITQNVDDLHREAGTR- 110
+P+ L E Y + KP HY + L+D G+L TQN+D L R AG
Sbjct: 90 HPEPFFALAKELYPGQF------KPTICHYFMRLLKDKGLLLRCYTQNIDTLERIAGLEQ 143
Query: 111 -NLIELHGNIFRVKCTKCNFKEYLKESQRLEEVLKEDLPKCPRCGSLLRPDVVWFGEPLP 169
+L+E HG + C + + S E++ E PKC C SL++PD+V+FGE LP
Sbjct: 144 EDLVEAHGTFYTSHCVSASCRHEYPLSWMKEKIFSEVTPKCEDCQSLVKPDIVFFGESLP 203
Query: 170 REELDRAFKLAEKADAVLVVGTSGLVYPAA 199
K D +LV+GTS V P A
Sbjct: 204 ARFFSCMQSDFLKVDLLLVMGTSLQVQPFA 233
>gb|AAF53248.1| (AE003639) Sir2 gene product [Drosophila melanogaster]
Length = 823
Score = 103 bits (255), Expect = 2e-21
Identities = 76/277 (27%), Positives = 128/277 (45%), Gaps = 44/277 (15%)
Query: 4 EVARVLASSKNAIAFTGAGISAESGVPTFRGKDGLWNKYRPE--ELATPEA------FAR 55
+V ++ S+ I TGAG+S G+P FR +G++ + + +L P+A F R
Sbjct: 213 DVISLVKKSQKIIVLTGAGVSVSCGIPDFRSTNGIYARLAHDFPDLPDPQAMFDINYFKR 272
Query: 56 NPKLVWEFYKWRINKILKAK--PNPAHYALVELEDMGILRAVITQNVDDLHREAGTRNLI 113
+P+ FYK+ +I + P+P H + LE G L TQN+D L R AG + +I
Sbjct: 273 DPR---PFYKFA-REIYPGEFQPSPCHRFIKMLETKGKLLRNYTQNIDTLERVAGIQRVI 328
Query: 114 ELHGNIFRVKCTKCNFKEYLKESQRLEEVLKEDLPKCPRC-------------------- 153
E HG+ CTKC FK ++ + +P CP+C
Sbjct: 329 ECHGSFSTASCTKCRFK--CNADALRADIFAQRIPVCPQCQPNKEQSVDASVAVTEEELR 386
Query: 154 ----GSLLRPDVVWFGEPLPREELDRAFKLAEKADAVLVVGTSGLVYPAAYIPYIVKESG 209
+++PD+V+FGE LP E + D ++V+G+S V P A+IP +
Sbjct: 387 QLVENGIMKPDIVFFGEGLPDEYHTVMATDKDVCDLLIVIGSSLKVRPVAHIPSSIP--- 443
Query: 210 GTVIEVNVEESAITPIA-DFFLRGRAGEVLPRVVHEV 245
TV ++ + + + D L G + ++ ++ H +
Sbjct: 444 ATVPQILINREQLHHLKFDVELLGDSDVIINQICHRL 480
>gi|11433001 SIR2 (silent mating type information regulation 2, S.cerevisiae,
homolog)-like [Homo sapiens]
Length = 373
Score = 103 bits (255), Expect = 2e-21
Identities = 73/210 (34%), Positives = 100/210 (46%), Gaps = 21/210 (10%)
Query: 5 VARVLASSK--NAIAFTGAGISAESGVPTFRGKD-GLWNKYRPEELATPEA------FAR 55
VAR + S + I GAGIS +G+P FR GL++ L PEA F +
Sbjct: 51 VARYMQSERCRRVICLVGAGISTSAGIPDFRSPSTGLYDNLEKYHLPYPEAIFEISYFKK 110
Query: 56 NPK----LVWEFYKWRINKILKAKPNPAHYALVELEDMGILRAVITQNVDDLHREAGTR- 110
+P+ L E Y + KP HY + L+D G+L TQN+D L R AG
Sbjct: 111 HPEPFFALAKELYPGQF------KPTICHYFMRLLKDKGLLLRCYTQNIDTLERIAGLEQ 164
Query: 111 -NLIELHGNIFRVKCTKCNFKEYLKESQRLEEVLKEDLPKCPRCGSLLRPDVVWFGEPLP 169
+L+E HG + C + + S E++ E PKC C SL++PD+V+FGE LP
Sbjct: 165 EDLVEAHGTFYTSHCVSASCRHEYPLSWMKEKIFSEVTPKCEDCQSLVKPDIVFFGESLP 224
Query: 170 REELDRAFKLAEKADAVLVVGTSGLVYPAA 199
K D +LV+GTS V P A
Sbjct: 225 ARFFSCMQSDFLKVDLLLVMGTSLQVQPFA 254
>pir||T22325 hypothetical protein F46G10.3 - Caenorhabditis elegans
>gi|3877259|emb|CAA90547.1| (Z50177) contains similarity
to Pfam domain: PF02146 (Sir2 family), Score=320.6,
E-value=5.9e-93, N=1 [Caenorhabditis elegans]
Length = 287
Score = 103 bits (254), Expect = 2e-21
Identities = 80/258 (31%), Positives = 116/258 (44%), Gaps = 39/258 (15%)
Query: 16 IAFTGAGISAESGVPTFRGKD-GLWNKYRPEELATPEAFARNPKL---VWEFYKWRINKI 71
+ TGAGIS ESG+P +R KD GL+ K E + + F ++ K W +
Sbjct: 31 LIITGAGISTESGIPDYRSKDVGLYTKTALEPIYFQD-FMKSKKCRQRYWSRSYLNWPRF 89
Query: 72 LKAKPNPAHYALVELEDMGILRAVITQNVDDLHREAGTRNLIELHGNIFRVKCTKCNFKE 131
+A PN HYAL + E +ITQNVD LH +AG++ + ELHGN +VKCT C E
Sbjct: 90 AQALPNFNHYALSKWEAANKFHWLITQNVDGLHLKAGSKMITELHGNALQVKCTSC---E 146
Query: 132 YLKESQRLEEVL-------KED------------------------LPKCPRCGSLLRPD 160
Y++ Q ++ L KE +P+C CG L++ D
Sbjct: 147 YIETRQTYQDRLNYANPGFKEQFVSPGQQELDADTALPLGSEQGFKIPECLNCGGLMKTD 206
Query: 161 VVWFGEPLPREELDRAFKLAEKADAVLVVGTSGLVYPAAYIPYIVKESGGTVIEVNVEES 220
V FGE L +++ K + + VL +GTS V I + VN+ +
Sbjct: 207 VTLFGENLNTDKIKVCGKKVNECNGVLTLGTSLEVLSGYQIVNHAHMQNKPIFIVNIGPT 266
Query: 221 AITPIADFFLRGRAGEVL 238
+A L R +VL
Sbjct: 267 RADQMATMKLDYRISDVL 284
>pir||T40929 transcription regulator SIR2 homolog - fission yeast
(Schizosaccharomyces pombe) >gi|6048262|emb|CAB58129.1|
(AL121807) putative SIR2-like transcriptional regulatory
protein [Schizosaccharomyces pombe]
Length = 332
Score = 102 bits (253), Expect = 3e-21
Identities = 79/248 (31%), Positives = 121/248 (47%), Gaps = 25/248 (10%)
Query: 13 KNAIAFTGAGISAESGVPTFRGKD-GLWNKYRPEELATPEA------FARNPKLVWEFYK 65
K GAGIS +G+P FR + G++N + L EA F +NP+ +E
Sbjct: 28 KKICVMVGAGISTAAGIPDFRSPETGIYNNLQRFNLPYAEAVFDLSYFRKNPRPFYELAH 87
Query: 66 WRINKILKAKPNPAHYALVELEDMGILRAVITQNVDDLHREAGT--RNLIELHGNIFRVK 123
+ + K +P HY + L D +L+ TQN+D L R AG + LIE HG+ +
Sbjct: 88 ELMPE--KYRPTYTHYFIRLLHDKRLLQKCYTQNIDTLERLAGVPDKALIEAHGSFQYSR 145
Query: 124 CTKCNFK---EYLKESQRLEEVLKEDLPKCPRCGSLLRPDVVWFGEPLPREELDRAFKLA 180
C +C EY++ ++++ +PKC C L++P +V++GE LP + K
Sbjct: 146 CIECYEMAETEYVRAC-----IMQKQVPKCNSCKGLIKPMIVFYGEGLPMRFFEHMEKDT 200
Query: 181 EKADAVLVVGTSGLVYPAAYIPYIVKESGGTVIEVNVEESAITPIADFFLRGRAGEVLPR 240
+ D LV+GTS LV+P A +P IV V+ +N E P DF R + +L
Sbjct: 201 KVCDMALVIGTSLLVHPFADLPEIVPNKCQRVL-INRE-----PAGDFGERKKDIMILGD 254
Query: 241 VVHEVRRL 248
+VR L
Sbjct: 255 CDSQVRAL 262
>gi|7657575 sir2-like 1; sirtuin type 1 [Homo sapiens]
>gi|11430951|ref|XP_005807.1| sir2-like 1 [Homo sapiens]
>gi|7555471|gb|AAD40849.2|AF083106_1 (AF083106) sirtuin
type 1 [Homo sapiens]
>gi|11596121|gb|AAG38486.1|AF235040_1 (AF235040)
SIR2alpha protein [Homo sapiens]
Length = 747
Score = 102 bits (251), Expect = 5e-21
Identities = 63/215 (29%), Positives = 112/215 (51%), Gaps = 19/215 (8%)
Query: 2 IVEVARVLASSKNAIAFTGAGISAESGVPTFRGKDGLWNKYR--------PEELATPEAF 53
I + ++L K I TGAG+S G+P FR +DG++ + P+ + E F
Sbjct: 243 IEDAVKLLQECKKIIVLTGAGVSVSCGIPDFRSRDGIYARLAVDFPDLPDPQAMFDIEYF 302
Query: 54 ARNPKLVWEFYKWRINKILKAKPNPAHYALVELEDMGILRAVITQNVDDLHREAGTRNLI 113
++P+ ++F K + +P+ H + + G L TQN+D L + AG + +I
Sbjct: 303 RKDPRPFFKFAKEIYPG--QFQPSLCHKFIALSDKEGKLLRNYTQNIDTLEQVAGIQRII 360
Query: 114 ELHGNIFRVKCTKCNFKEYLKESQRLEEVLKEDLPKCPRCG-----SLLRPDVVWFGEPL 168
+ HG+ C C +K + + ++ + +P+CPRC ++++P++V+FGE L
Sbjct: 361 QCHGSFATASCLICKYKVDCEAVR--GDIFNQVVPRCPRCPADEPLAIMKPEIVFFGENL 418
Query: 169 PREELDRAFKL-AEKADAVLVVGTSGLVYPAAYIP 202
P E+ RA K ++ D ++V+G+S V P A IP
Sbjct: 419 P-EQFHRAMKYDKDEVDLLIVIGSSLKVRPVALIP 452
>emb|CAC04174.1| (AL133551) bA57G10.4 (SIRT1, Sir2-like proteins (siruitins) type 1)
[Homo sapiens]
Length = 555
Score = 102 bits (251), Expect = 5e-21
Identities = 63/215 (29%), Positives = 112/215 (51%), Gaps = 19/215 (8%)
Query: 2 IVEVARVLASSKNAIAFTGAGISAESGVPTFRGKDGLWNKYR--------PEELATPEAF 53
I + ++L K I TGAG+S G+P FR +DG++ + P+ + E F
Sbjct: 51 IEDAVKLLQECKKIIVLTGAGVSVSCGIPDFRSRDGIYARLAVDFPDLPDPQAMFDIEYF 110
Query: 54 ARNPKLVWEFYKWRINKILKAKPNPAHYALVELEDMGILRAVITQNVDDLHREAGTRNLI 113
++P+ ++F K + +P+ H + + G L TQN+D L + AG + +I
Sbjct: 111 RKDPRPFFKFAKEIYPG--QFQPSLCHKFIALSDKEGKLLRNYTQNIDTLEQVAGIQRII 168
Query: 114 ELHGNIFRVKCTKCNFKEYLKESQRLEEVLKEDLPKCPRCG-----SLLRPDVVWFGEPL 168
+ HG+ C C +K + + ++ + +P+CPRC ++++P++V+FGE L
Sbjct: 169 QCHGSFATASCLICKYKVDCEAVR--GDIFNQVVPRCPRCPADEPLAIMKPEIVFFGENL 226
Query: 169 PREELDRAFKL-AEKADAVLVVGTSGLVYPAAYIP 202
P E+ RA K ++ D ++V+G+S V P A IP
Sbjct: 227 P-EQFHRAMKYDKDEVDLLIVIGSSLKVRPVALIP 260
>pir||C64677 conserved hypothetical protein HP1259 - Helicobacter pylori
(strain 26695) >gi|2314426|gb|AAD08305.1| (AE000631)
conserved hypothetical protein [Helicobacter pylori
26695]
Length = 205
Score = 101 bits (250), Expect = 7e-21
Identities = 60/155 (38%), Positives = 89/155 (56%), Gaps = 12/155 (7%)
Query: 46 ELATPEAFARNPKLVWEFYKWRINKILKAKPNPAHYALVELEDMGILRAVITQNVDDLHR 105
E+A+P + +NP+ V +FY R ++ + PN AH AL ELE + +ITQNVDDLH
Sbjct: 11 EVASPYGWKKNPQKVLDFYNQRRRQLFEVYPNKAHKALAELEKHYQVN-IITQNVDDLHE 69
Query: 106 EAGTRNLIELHGNIFRVKCTK-CNFKEYLKESQRLEEVLKEDLPKCPRCGSLLRPDVVWF 164
AG+ ++ LHG + V+ K N ++ L ++ K+ S LRPD+VWF
Sbjct: 70 RAGSSRILHLHGELLSVRSEKDPNLVYRWEKDLNLGDLAKDK--------SQLRPDIVWF 121
Query: 165 GEPLPREELDRAFKLAEKADAVLVVGTSGLVYPAA 199
GE +P L A L ++A ++++GTS VYPAA
Sbjct: 122 GEAVPL--LKEAISLVKQAHLLIIIGTSLQVYPAA 154
>pir||T22324 hypothetical protein F46G10.7 - Caenorhabditis elegans
>gi|3877258|emb|CAA90546.1| (Z50177) contains similarity
to Pfam domain: PF02146 (Sir2 family), Score=340.4,
E-value=6.3e-99, N=1~cDNA EST yk300f10.3 comes from this
gene~cDNA EST yk522h8.3 comes from this gene~cDNA EST
yk522h8.5 comes from this gene [Caenorhabditis elegans]
Length = 287
Score = 101 bits (250), Expect = 7e-21
Identities = 66/210 (31%), Positives = 105/210 (49%), Gaps = 35/210 (16%)
Query: 16 IAFTGAGISAESGVPTFRGKD-GLWNKYRPEELATPEAFARNP--KLVWE--FYKWRINK 70
+ +GAGIS ESG+P +R KD GL+ + + + + N + W F W +
Sbjct: 31 LVISGAGISTESGIPDYRSKDVGLYARIAHKPIYFQDYMRSNRCRQRYWSRNFLAWP--R 88
Query: 71 ILKAKPNPAHYALVELEDMGILRAVITQNVDDLHREAGTRNLIELHGNIFRVKCTKCNFK 130
+A PN HYAL + E + +ITQNVD LH +AG++ + ELHG+ +VKCT C++
Sbjct: 89 FGQAAPNINHYALSKWEASDRFQWLITQNVDGLHLKAGSKMVTELHGSALQVKCTTCDYI 148
Query: 131 E----------YLKESQRLEEVLKEDL------------------PKCPRCGSLLRPDVV 162
E Y + E V +L P+CP CG L++ DV
Sbjct: 149 ESRQTYQDRLDYANPGFKEEHVAPGELAPDGDIILPLGTEKGFQIPECPSCGGLMKTDVT 208
Query: 163 WFGEPLPREELDRAFKLAEKADAVLVVGTS 192
+FGE + ++++ ++ + D +L +GTS
Sbjct: 209 FFGENVNMDKVNFCYEKVNECDGILSLGTS 238
>gb|AAD20046.1| (AF131800) Similar to rat 5E5 antigen [Homo sapiens]
Length = 254
Score = 101 bits (249), Expect = 9e-21
Identities = 70/203 (34%), Positives = 97/203 (47%), Gaps = 21/203 (10%)
Query: 5 VARVLASSK--NAIAFTGAGISAESGVPTFRGKD-GLWNKYRPEELATPEA------FAR 55
VAR + S + I GAGIS +G+P FR GL++ L PEA F +
Sbjct: 50 VARYMQSERCRRVICLVGAGISTSAGIPDFRSPSTGLYDNLEKYHLPYPEAIFEISYFKK 109
Query: 56 NPK----LVWEFYKWRINKILKAKPNPAHYALVELEDMGILRAVITQNVDDLHREAGTR- 110
+P+ L E Y + KP HY + L+D G+L TQN+D L R AG
Sbjct: 110 HPEPFFALAKELYPGQF------KPTICHYFMRLLKDKGLLLRCYTQNIDTLERIAGLEQ 163
Query: 111 -NLIELHGNIFRVKCTKCNFKEYLKESQRLEEVLKEDLPKCPRCGSLLRPDVVWFGEPLP 169
+L+E HG + C + + S E++ E PKC C SL++PD+V+FGE LP
Sbjct: 164 EDLVEAHGTFYTSHCVSASCRHEYPLSWMKEKIFSEVTPKCEDCQSLVKPDIVFFGESLP 223
Query: 170 REELDRAFKLAEKADAVLVVGTS 192
K D +LV+GTS
Sbjct: 224 ARFFSCMQSDFLKVDLLLVMGTS 246
>gi|9790229 Sir2 alpha protein; Sir2 alpha [Mus musculus]
>gi|6693711|gb|AAF24983.1|AF214646_1 (AF214646)
Sir2alpha protein [Mus musculus]
Length = 737
Score = 101 bits (249), Expect = 9e-21
Identities = 62/215 (28%), Positives = 112/215 (51%), Gaps = 19/215 (8%)
Query: 2 IVEVARVLASSKNAIAFTGAGISAESGVPTFRGKDGLWNKYR--------PEELATPEAF 53
I + ++L K I TGAG+S G+P FR +DG++ + P+ + E F
Sbjct: 235 IEDAVKLLQECKKIIVLTGAGVSVSCGIPDFRSRDGIYARLAVDFPDLPDPQAMFDIEYF 294
Query: 54 ARNPKLVWEFYKWRINKILKAKPNPAHYALVELEDMGILRAVITQNVDDLHREAGTRNLI 113
++P+ ++F K + +P+ H + + G L TQN+D L + AG + ++
Sbjct: 295 RKDPRPFFKFAKEIYPG--QFQPSLCHKFIALSDKEGKLLRNYTQNIDTLEQVAGIQRIL 352
Query: 114 ELHGNIFRVKCTKCNFKEYLKESQRLEEVLKEDLPKCPRCG-----SLLRPDVVWFGEPL 168
+ HG+ C C +K + + ++ + +P+CPRC ++++P++V+FGE L
Sbjct: 353 QCHGSFATASCLICKYKVDCEAVR--GDIFNQVVPRCPRCPADEPLAIMKPEIVFFGENL 410
Query: 169 PREELDRAFKL-AEKADAVLVVGTSGLVYPAAYIP 202
P E+ RA K ++ D ++V+G+S V P A IP
Sbjct: 411 P-EQFHRAMKYDKDEVDLLIVIGSSLKVRPVALIP 444
>gb|AAG22161.1| (AE003730) CG5085 gene product [Drosophila melanogaster]
Length = 355
Score = 101 bits (249), Expect = 9e-21
Identities = 68/200 (34%), Positives = 99/200 (49%), Gaps = 21/200 (10%)
Query: 13 KNAIAFTGAGISAESGVPTFRGK-DGLWNKYRPEELATPEA------FARNPK----LVW 61
+ + GAGIS +G+P FR GL++ + EL P A F +NP L
Sbjct: 48 RKIVTMVGAGISTSAGIPDFRSPGSGLYSNLKKYELPHPTAIFDLDYFEKNPAPFFALAK 107
Query: 62 EFYKWRINKILKAKPNPAHYALVELEDMGILRAVITQNVDDLHREAGTRN--LIELHGNI 119
E Y P PAHY + L D G+L+ TQN+D L R G +IE HG+
Sbjct: 108 ELYPGSFI------PTPAHYFIRLLNDKGLLQRHYTQNIDTLDRLTGLPEDKIIEAHGSF 161
Query: 120 FRVKCTKCNFKEYLKESQRLEEVLKEDLPKCPRCGSLLRPDVVWFGEPLPREELDRAFKL 179
C KC KEY + + E + + LPKC +C +++PD+V+FGE LP+ +
Sbjct: 162 HTNHCIKCR-KEYDMDWMKAE-IFADRLPKCQKCQGVVKPDIVFFGENLPKRFYSSPEED 219
Query: 180 AEKADAVLVVGTSGLVYPAA 199
+ D ++++GTS V P A
Sbjct: 220 FQDCDLLIIMGTSLEVQPFA 239
>gb|AAG33227.1| (AF302278) SIR2L3 [Mus musculus] >gi|11612479|gb|AAG39257.1|
(AF299338) SIR2L3 isoform A [Mus musculus]
>gi|11612481|gb|AAG39258.1| (AF299339) SIR2L3 isoform B
[Mus musculus]
Length = 257
Score = 99.8 bits (245), Expect = 3e-20
Identities = 82/245 (33%), Positives = 116/245 (46%), Gaps = 30/245 (12%)
Query: 20 GAGISAESGVPTFRGK-DGLWNKYRPEELATPEA------FARNPK----LVWEFYKWRI 68
GAGIS SG+P FR GL++ + ++ PEA F NPK L E Y
Sbjct: 3 GAGISTPSGIPDFRSPGSGLYSNLQQYDIPYPEAIFELGFFFHNPKPFFMLAKELYPGHY 62
Query: 69 NKILKAKPNPAHYALVELEDMGILRAVITQNVDDLHREAG--TRNLIELHGNIFRVKCTK 126
+PN HY L L D +L + TQN+D L R +G L+E HG CT
Sbjct: 63 ------RPNVTHYFLRLLHDKELLLRLYTQNIDGLERASGIPASKLVEAHGTFVTATCTV 116
Query: 127 CNFKEYLKESQRLEEVLKEDLPKCPRCGSLLRPDVVWFGEPLPREELDRAFKLAEKADAV 186
C + +V+ + +P+C C +++PD+V+FGE LP L A AD +
Sbjct: 117 C--RRSFPGEDIWADVMADRVPRCAVCTGVVKPDIVFFGEQLPARFLLHMADFA-LADLL 173
Query: 187 LVVGTSGLVYPAAYIPYIVKESGGTVIEVNVEESAITPIADFFLRGRAGEV--LPRVVHE 244
L++GTS V P A + V++S V + + + P F L R +V L VVH
Sbjct: 174 LILGTSLEVEPFASLSEAVQKS---VPRLLINRDLVGP---FVLSPRRKDVVQLGDVVHG 227
Query: 245 VRRLL 249
V RL+
Sbjct: 228 VERLV 232
>pir||T35951 probable SIR2 family transcription regulator - Streptomyces
coelicolor (fragment) >gi|4158210|emb|CAA22773.1|
(AL035206) putative SIR2 family transcriptional
regulator [Streptomyces coelicolor A3(2)]
Length = 190
Score = 98.3 bits (241), Expect = 8e-20
Identities = 62/178 (34%), Positives = 91/178 (50%), Gaps = 3/178 (1%)
Query: 67 RINKILKAKPNPAHYALVELEDMGILRAVITQNVDDLHREAGT--RNLIELHGNIFRVKC 124
R + L A+PN AH A+ +LE G+ V+TQNVD LH+ AG R ++ELHG C
Sbjct: 10 RDSAALHAEPNAAHRAVADLERRGVPVRVLTQNVDGLHQLAGVSARKVLELHGTARDCVC 69
Query: 125 TKCNFKEYLKESQRLEEVLKEDLPKCPRCGSLLRPDVVWFGEPLPREELDRAFKLAEKAD 184
T C + + + E ++D P C CG +L+ V FGE L L A +++
Sbjct: 70 TGCGARGPMADVLARIEAGEDD-PPCLDCGGVLKTATVMFGERLDPVVLGEAAAISKACQ 128
Query: 185 AVLVVGTSGLVYPAAYIPYIVKESGGTVIEVNVEESAITPIADFFLRGRAGEVLPRVV 242
+ VGTS V PAA + + E G ++ VN E + +AD +R G LP ++
Sbjct: 129 VFVAVGTSLQVEPAAGLARVAVEHGARLVVVNAEPTPYDELADEVIREPIGSALPALL 186
>gb|AAG39256.1| (AF299337) SIR2L2 [Mus musculus]
Length = 389
Score = 97.9 bits (240), Expect = 1e-19
Identities = 63/200 (31%), Positives = 96/200 (47%), Gaps = 19/200 (9%)
Query: 13 KNAIAFTGAGISAESGVPTFRGKD-GLWNKYRPEELATPEA------FARNPK----LVW 61
+ I GAGIS +G+P FR GL+ L PEA F ++P+ L
Sbjct: 77 RKVICLVGAGISTSAGIPDFRSPSTGLYANLEKYHLPYPEAIFEISYFKKHPEPFFALAK 136
Query: 62 EFYKWRINKILKAKPNPAHYALVELEDMGILRAVITQNVDDLHREAGT--RNLIELHGNI 119
E Y + KP HY + L++ G+L TQN+D L R AG ++L+E HG
Sbjct: 137 ELYPGQF------KPTICHYFIRLLKEKGLLLRCYTQNIDTLERVAGLEPQDLVEAHGTF 190
Query: 120 FRVKCTKCNFKEYLKESQRLEEVLKEDLPKCPRCGSLLRPDVVWFGEPLPREELDRAFKL 179
+ C + ++ E++ E P+C +C S+++PD+V+FGE LP
Sbjct: 191 YTSHCVNTSCRKEYTMGWMKEKIFSEATPRCEQCQSVVKPDIVFFGENLPSRFFSCMQSD 250
Query: 180 AEKADAVLVVGTSGLVYPAA 199
K D ++++GTS V P A
Sbjct: 251 FSKVDLLIIMGTSLQVQPFA 270
>pir||T18247 transcription regulatory protein - yeast (Candida albicans)
>gi|3859681|emb|CAA22018.1| (AL033503) transcription
regulatory protein [Candida albicans]
Length = 331
Score = 97.5 bits (239), Expect = 1e-19
Identities = 71/212 (33%), Positives = 101/212 (47%), Gaps = 23/212 (10%)
Query: 5 VARVLASSKNAIAFTGAGISAESGVPTFRGKD-GLWNKYRPEELATPEA------FARNP 57
VA + + K F GAGIS +G+P FR D GL+ L EA F +P
Sbjct: 11 VAEAVKNGKKVTFFNGAGISTGAGIPDFRSPDTGLYANLAKLNLPFAEAVFDIDFFKEDP 70
Query: 58 K----LVWEFYKWRINKILKAKPNPAHYALVELEDMGILRAVITQNVDDLHREAGTRN-- 111
K L E Y P H+ + L+D G L+ V TQN+D L R AG +
Sbjct: 71 KPFYTLAEELYPGNF------APTKFHHFIKLLQDQGSLKRVYTQNIDTLERLAGVEDKY 124
Query: 112 LIELHGNIFRVKCTKCNFKEYLKESQRLEEVLKED-LPKCPRCGSLLRPDVVWFGEPLPR 170
++E HG+ C C+ KE E+ L+ +K+ +P C C ++PD+V+FGE LP
Sbjct: 125 IVEAHGSFASNHCVDCH-KEMTTET--LKTYMKDKKIPSCQHCEGYVKPDIVFFGEGLPV 181
Query: 171 EELDRAFKLAEKADAVLVVGTSGLVYPAAYIP 202
+ D E + +V GTS V+P A +P
Sbjct: 182 KFFDLWEDDCEDVEVAIVAGTSLTVFPFASLP 213
>gi|6325242 similar to Sir2p; Hst2p [Saccharomyces cerevisiae]
>gi|1708326|sp|P53686|HST2_YEAST HST2 PROTEIN
(HOMOLOGOUS TO SIR2 PROTEIN 2) >gi|2131291|pir||S59678
HST2 protein - yeast (Saccharomyces cerevisiae)
>gi|965078|gb|AAB68090.1| (U33335) Lpa2p [Saccharomyces
cerevisiae] >gi|1055024|gb|AAA81035.1| (U39063) Hst2p
[Saccharomyces cerevisiae]
Length = 357
Score = 95.6 bits (234), Expect = 5e-19
Identities = 76/230 (33%), Positives = 112/230 (48%), Gaps = 39/230 (16%)
Query: 4 EVARVLASSKNA--IAFTGAGISAESGVPTFRGKD-GLWNKYRPEELATPEA------FA 54
++A + S+ NA I GAGIS G+P FR GL++ +L PEA F
Sbjct: 14 KIAAHMKSNPNAKVIFMVGAGISTSCGIPDFRSPGTGLYHNLARLKLPYPEAVFDVDFFQ 73
Query: 55 RNP----KLVWEFYKWRINKILKAKPNPAHYALVELEDMGILRAVITQNVDDLHREAGTR 110
+P L E Y +P+ HY L +D +L+ V TQN+D L R+AG +
Sbjct: 74 SDPLPFYTLAKELYPGNF------RPSKFHYLLKLFQDKDVLKRVYTQNIDTLERQAGVK 127
Query: 111 N--LIELHGNIFRVKCTKCN--FKEYLKESQRLEEVLKEDLPKCPRCGSLLRPDVVWFGE 166
+ +IE HG+ C C + + +S+ E +K D KC CG L++P +V+FGE
Sbjct: 128 DDLIIEAHGSFAHCHCIGCGKVYPPQVFKSKLAEHPIK-DFVKCDVCGELVKPAIVFFGE 186
Query: 167 PLP--------------REELDRAFKLAEKADAVLVVGTSGLVYPAAYIP 202
LP RE++ + K ++ V+VVGTS VYP A +P
Sbjct: 187 DLPDSFSETWLNDSEWLREKITTSGKHPQQ-PLVIVVGTSLAVYPFASLP 235
>gb|AAG32038.1| (AF302272) SIR2L2 [Mus musculus]
Length = 389
Score = 94.0 bits (230), Expect = 2e-18
Identities = 62/200 (31%), Positives = 95/200 (47%), Gaps = 19/200 (9%)
Query: 13 KNAIAFTGAGISAESGVPTFRGKD-GLWNKYRPEELATPEA------FARNPK----LVW 61
+ I GAGIS +G+P FR GL+ L PEA F ++P+ L
Sbjct: 77 RKVICLVGAGISTSAGIPDFRSPSTGLYANLEKYHLPYPEAIFEISYFKKHPEPFFALAK 136
Query: 62 EFYKWRINKILKAKPNPAHYALVELEDMGILRAVITQNVDDLHREAGT--RNLIELHGNI 119
E Y + KP HY + L++ G+L TQN+D L R AG ++L+E HG
Sbjct: 137 ELYPGQF------KPTICHYFIRLLKEKGLLLRCYTQNIDTLERVAGLEPQDLVEAHGTF 190
Query: 120 FRVKCTKCNFKEYLKESQRLEEVLKEDLPKCPRCGSLLRPDVVWFGEPLPREELDRAFKL 179
+ C + ++ E++ E P+C +C S+++ D+V+FGE LP
Sbjct: 191 YTSHCVNTSCRKEYTMGWMKEKIFSEATPRCEQCQSVVKLDIVFFGENLPSRFFSCMQSD 250
Query: 180 AEKADAVLVVGTSGLVYPAA 199
K D ++++GTS V P A
Sbjct: 251 FSKVDLLIIMGTSLQVQPFA 270
>sp|Q25337|SIR2_LEIMA REGULATORY PROTEIN SIR2 HOMOLOG (LMSIR2RP) >gi|2133375|pir||JC4639
silent information regulator 2-related protein -
Leishmania major >gi|1203987|gb|AAB06804.1| (L40331)
homologuous to yeast silent information regulatory 2
protein [Leishmania major]
Length = 381
Score = 92.4 bits (226), Expect = 5e-18
Identities = 61/205 (29%), Positives = 101/205 (48%), Gaps = 11/205 (5%)
Query: 13 KNAIAFTGAGISAESGVPTFRGKD-GLWNKYRPEELATP-EAFA-----RNPKLVWEFYK 65
+ + GAG S +G+P FR D G++ K L P +AF+ P++ + +
Sbjct: 32 RRILVLVGAGASVAAGIPDFRSSDTGIYAKLGKYNLDDPTDAFSLTLLREKPEIFYSIAR 91
Query: 66 WRINKILKAKPNPAHYALVELEDMGILRAVITQNVDDLHREAGTRN--LIELHGNIFRVK 123
+P H+ + L+D G L TQN+D L + AG L+E HG+
Sbjct: 92 ELNLWPGHFQPTAVHHFIRLLQDEGRLLRCCTQNIDGLEKAAGVSPELLVEAHGSFAAAA 151
Query: 124 CTKCNFKEYLKESQRLEEVLKEDLPKCPRCGSLLRPDVVWFGEPLPREELDRAFKLAEKA 183
C +C+ ++ Q E + + +C CG +++P+VV+FGE LP D A A
Sbjct: 152 CIECHTPFSIE--QNYLEAMSGTVSRCSTCGGIVKPNVVFFGENLPDAFFDALHHDAPIA 209
Query: 184 DAVLVVGTSGLVYPAAYIPYIVKES 208
+ V+++GTS V+P A +P +V +S
Sbjct: 210 ELVIIIGTSMQVHPFALLPCVVPKS 234
>gb|AAF54513.1| (AE003686) CG6284 gene product [Drosophila melanogaster]
Length = 317
Score = 90.9 bits (222), Expect = 1e-17
Identities = 68/249 (27%), Positives = 118/249 (47%), Gaps = 29/249 (11%)
Query: 4 EVARVLASSKNAIAFTGAGISAESGVPTFRGKDGLWNKYRPEELATPEAFARNPKLVWEF 63
E+A ++ S + + TGAGIS +G+P FRG G+W T E P F
Sbjct: 36 ELAELIKKSGHVVLHTGAGISTSAGIPDFRGPKGVW---------TLEEKGEKPDFNVSF 86
Query: 64 YKWRINKILKAKPNPAHYALVELEDMGILRAVITQNVDDLHREAG--TRNLIELHGNIFR 121
+A+P H A++ L + G ++ VI+QN+D LH ++G + L ELHGNI+
Sbjct: 87 D--------EARPTKTHMAIIALIESGYVQYVISQNIDGLHLKSGLDRKYLSELHGNIYI 138
Query: 122 VKCTKCNFKEYLKES-------QRLEEVLKEDLPKCPR-CGS-LLRPDVVWFGEPLPREE 172
+C KC ++++ S + L+ K + R C S +L +V+ + LP +
Sbjct: 139 EQCKKCR-RQFVSPSAVETVGQKSLQRACKSSMDSKGRSCRSGILYDNVLDWEHDLPEND 197
Query: 173 LDRAFKLAEKADAVLVVGTSGLVYPAAYIPYIVKESGGTVIEVNVEESAITPIADFFLRG 232
L+ + AD + +GT+ + P+ +P + GG + N++ + A+ +
Sbjct: 198 LEMGVMHSTVADLNIALGTTLQIVPSGDLPLKNLKCGGKFVICNLQPTKHDKKANLIISS 257
Query: 233 RAGEVLPRV 241
VL +V
Sbjct: 258 YVDVVLSKV 266
>gb|AAC73004.1| (AF102869) Sir2 homolog [Trypanosoma brucei]
Length = 351
Score = 88.9 bits (217), Expect = 5e-17
Identities = 65/195 (33%), Positives = 96/195 (48%), Gaps = 12/195 (6%)
Query: 20 GAGISAESGVPTFRGKD-GLWNKYRPEELATPEAFARNPKLVWE---FYKWRINKIL--- 72
GAGIS +G+P FR GL+ K L +PE P L + FY ++ L
Sbjct: 37 GAGISVAAGIPDFRSPHTGLYAKLSRYNLNSPEDAFSLPLLRQQPSVFYNILMDMDLWPG 96
Query: 73 KAKPNPAHYALVELEDMGILRAVITQNVDDLHREAGTRN--LIELHGNIFRVKCTKCNFK 130
K P H+ + L G+L TQN+D L R G L+E HG+ C C+ K
Sbjct: 97 KYCPTTVHHFISLLAKKGMLLCCCTQNIDGLERACGIPESLLVEAHGSFSSASCVDCHAK 156
Query: 131 EYLKESQRLEEVLKEDLPKCPRCGSLLRPDVVWFGEPLPREELDRAFKLAEKADAVLVVG 190
+ ++ E +P C +CG +++PDVV+FGE LP E L E+ + +L++G
Sbjct: 157 YDINIARA--ETRAGKVPHCNQCGGIVKPDVVFFGENLP-EAFFNVAGLIEETELLLILG 213
Query: 191 TSGLVYPAAYIPYIV 205
TS V+P A + +V
Sbjct: 214 TSLQVHPFADLALMV 228
>gb|AAF46055.1| (AE003435) CG3187 gene product [Drosophila melanogaster]
Length = 204
Score = 88.9 bits (217), Expect = 5e-17
Identities = 55/157 (35%), Positives = 82/157 (52%), Gaps = 10/157 (6%)
Query: 9 LASSKNAIAFTGAGISAESGVPTFRGKD-GLW--NKYRPEELATPEAFARNPKLVW--EF 63
L S N + TGAGIS ESG+P +R + GL+ + ++P + + K W F
Sbjct: 42 LLSKPNVLVLTGAGISTESGIPDYRSEGVGLYARSNHKPVQHMEFVKSSAVRKRYWARNF 101
Query: 64 YKWRINKILKAKPNPAHYALVELEDMGILRAVITQNVDDLHREAGTRNLIELHGNIFRVK 123
W K +PN H+AL E ++AV+TQNVD LH +AG+RN++E+HG+ + VK
Sbjct: 102 VGWP--KFSATQPNATHHALARFEREERVQAVVTQNVDRLHTKAGSRNVVEVHGSGYVVK 159
Query: 124 CTKCNFKEYLKESQRLEEVLKEDLPKCPRCGSLLRPD 160
C C EY + + +L P ++RPD
Sbjct: 160 CLSC---EYRIDRHEFQSILASLNPAFKDAPDMIRPD 193
>pir||T25520 hypothetical protein C06A5.3 - Caenorhabditis elegans
>gi|1943780|gb|AAB52437.1| (U97193) similar to S.
cerevisiae SIR2 (SP:P06700) and mouse hepatoma derived
growth factor HDGF (NID:g945418) [Caenorhabditis elegans]
Length = 1095
Score = 86.2 bits (210), Expect = 3e-16
Identities = 64/226 (28%), Positives = 100/226 (43%), Gaps = 28/226 (12%)
Query: 11 SSKNAIAFTGAGISAESGVPTFRGKDGLWNKYRPEELATPEAFARNPKLVWEFYKWRINK 70
+ K GAG+S S +P FRGK G+W T +A ++ + V
Sbjct: 850 TGKPIFVLIGAGVSTGSKLPDFRGKQGVW---------TLQAEGKHAEGV---------D 891
Query: 71 ILKAKPNPAHYALVELEDMGILRAVITQNVDDLHREAG--TRNLIELHGNIFRVKCTKCN 128
A+P +H +++ L G ++ +ITQNVD L R+ G +LIE+HGN+F C C
Sbjct: 892 FQVARPGVSHKSILALHKAGYIKTIITQNVDGLDRKVGIPVEDLIEVHGNLFLEVCQSC- 950
Query: 129 FKEYLKESQRLEEVLKEDLPKCP-------RCGSLLRPDVVWFGEPLPREELDRAFKLAE 181
F EY++E + L C C LR + + + LDR K +
Sbjct: 951 FSEYVREEIVMSVGLCPTGRNCEGNKRTGRSCRGKLRDATLDWDTEISLNHLDRIRKAWK 1010
Query: 182 KADAVLVVGTSGLVYPAAYIPYIVKESGGTVIEVNVEESAITPIAD 227
+ +L +GTS + P +P K G +N +E+A I +
Sbjct: 1011 QTSHLLCIGTSLEIIPMGSLPLDAKSKGIKTTTINYQETAHEKIVE 1056
>gi|7706712 sir2-related protein type 7; sirtuin type 7 [Homo sapiens]
>gi|7243747|gb|AAF43431.1|AF233395_1 (AF233395)
sir2-related protein type 7 [Homo sapiens]
Length = 400
Score = 79.2 bits (192), Expect = 4e-14
Identities = 55/201 (27%), Positives = 98/201 (48%), Gaps = 33/201 (16%)
Query: 4 EVARVLASSKNAIAFTGAGISAESGVPTFRGKDGLWNKYRPEELATPEAFARNPKLVWEF 63
E+A + ++K + +TGAGIS + +P +RG +G+W L+ +
Sbjct: 91 ELASAVRNAKYLVVYTGAGISTAASIPDYRGPNGVWT------------------LLQKG 132
Query: 64 YKWRINKILKAKPNPAHYALVELEDMGILRAVITQNVDDLHREAGTRN--LIELHGNIFR 121
+ +A+P H ++ L + +++ V++QN D LH +G + ELHGN++
Sbjct: 133 RSVSAADLSEAEPTLTHMSITRLHEQKLVQHVVSQNCDGLHLRSGLPRTAISELHGNMYI 192
Query: 122 VKCTKC-NFKEYLK---ESQRLEEVLKEDLPKCPRCGSLLRPDVVWFGE------PLPRE 171
CT C +EY++ ++R + C +CG+ LR +V FGE PL
Sbjct: 193 EVCTSCVPNREYVRVFDVTERTALHRHQTGRTCHKCGTQLRDTIVHFGERGTLGQPL--- 249
Query: 172 ELDRAFKLAEKADAVLVVGTS 192
+ A + A +AD +L +G+S
Sbjct: 250 NWEAATEAASRADTILCLGSS 270
>gi|11427386 sir2-related protein type 7 [Homo sapiens]
Length = 409
Score = 79.2 bits (192), Expect = 4e-14
Identities = 55/201 (27%), Positives = 98/201 (48%), Gaps = 33/201 (16%)
Query: 4 EVARVLASSKNAIAFTGAGISAESGVPTFRGKDGLWNKYRPEELATPEAFARNPKLVWEF 63
E+A + ++K + +TGAGIS + +P +RG +G+W L+ +
Sbjct: 100 ELASAVRNAKYLVVYTGAGISTAASIPDYRGPNGVWT------------------LLQKG 141
Query: 64 YKWRINKILKAKPNPAHYALVELEDMGILRAVITQNVDDLHREAGTRN--LIELHGNIFR 121
+ +A+P H ++ L + +++ V++QN D LH +G + ELHGN++
Sbjct: 142 RSVSAADLSEAEPTLTHMSITRLHEQKLVQHVVSQNCDGLHLRSGLPRTAISELHGNMYI 201
Query: 122 VKCTKC-NFKEYLK---ESQRLEEVLKEDLPKCPRCGSLLRPDVVWFGE------PLPRE 171
CT C +EY++ ++R + C +CG+ LR +V FGE PL
Sbjct: 202 EVCTSCVPNREYVRVFDVTERTALHRHQTGRTCHKCGTQLRDTIVHFGERGTLGQPL--- 258
Query: 172 ELDRAFKLAEKADAVLVVGTS 192
+ A + A +AD +L +G+S
Sbjct: 259 NWEAATEAASRADTILCLGSS 279
>sp|O59923|SIR2_CANAL REGULATORY PROTEIN SIR2 >gi|3005095|gb|AAC09304.1| (AF045774) SIR2
[Candida albicans]
Length = 515
Score = 78.4 bits (190), Expect = 8e-14
Identities = 59/211 (27%), Positives = 95/211 (44%), Gaps = 22/211 (10%)
Query: 9 LASSKNAIAFTGAGISAESGVPTFRGKDGLWNKYRPEELATP------EAFARNPKLVWE 62
L+ +K + TGAGIS G+P FR GL+N+ L+ P + F R +L +
Sbjct: 231 LSRAKKIMVVTGAGISTSLGIPDFRSFKGLYNQLSKLNLSDPQKVFDLQTFMREGRLFYT 290
Query: 63 FYKWRINKILKAKPNPAHYALVELEDMGILRAVITQNVDDLHREAGTRN--LIELHGNIF 120
+ K + H L L+D L TQN+D+L + AG ++ L++ HG+
Sbjct: 291 IAHLVLPP--DGKFSLLHAFLKLLQDKHKLLRNYTQNIDNLEQRAGLKSEKLVQCHGSFA 348
Query: 121 RVKCTKCNFKEYLKESQRLEEVLKEDLPKCPRCG----------SLLRPDVVWFGEPLPR 170
+ KC C + + + ++ +P+C C ++P + +FGE LP
Sbjct: 349 KAKCVSC--QGIFAGEKIYNHIRRKQVPRCAICWKNTKQAPIHFGAIKPTITFFGEDLPE 406
Query: 171 EELDRAFKLAEKADAVLVVGTSGLVYPAAYI 201
K ++ D LV+GTS V P A I
Sbjct: 407 RFHTLMDKDLQQIDLFLVIGTSLKVEPVASI 437
>gi|6324504 Homolog of SIR2; Hst1p [Saccharomyces cerevisiae]
>gi|1708325|sp|P53685|HST1_YEAST HST1 PROTEIN
(HOMOLOGOUS TO SIR2 PROTEIN 1) >gi|2120023|pir||S59698
HST1 protein - yeast (Saccharomyces cerevisiae)
>gi|972893|gb|AAB38430.1| (L47120) homolog of SIR2;
transcribed ORF flanked by NUF2 (X72225) and RTG1
(M97690) [Saccharomyces cerevisiae]
>gi|1055020|gb|AAA81033.1| (U39041) Hst1p [Saccharomyces
cerevisiae] >gi|1419891|emb|CAA99078.1| (Z74810) ORF
YOL068c [Saccharomyces cerevisiae]
Length = 503
Score = 78.0 bits (189), Expect = 1e-13
Identities = 59/237 (24%), Positives = 103/237 (42%), Gaps = 46/237 (19%)
Query: 9 LASSKNAIAFTGAGISAESGVPTFRGKDGLWNKYR------PEELATPEAFARNPKLVWE 62
L ++K + TGAG+S G+P FR +G ++K R P+++ + F ++P + +
Sbjct: 197 LRNAKKILVLTGAGVSTSLGIPDFRSSEGFYSKIRHLGLEDPQDVFNLDIFLQDPSVFYN 256
Query: 63 FYKWRINKILKAKP--NPAHYALVELEDMGILRAVITQNVDDLHREAG--TRNLIELHGN 118
+ +L + +P H + L+D G L TQN+D+L AG L++ HG+
Sbjct: 257 I----AHMVLPPENMYSPLHSFIKMLQDKGKLLRNYTQNIDNLESYAGIDPDKLVQCHGS 312
Query: 119 IFRVKCTKCNFKEYLKESQRLEEVLKEDLPKCPRC------------------------- 153
C C+++ + + E + +LP CP C
Sbjct: 313 FATASCVTCHWQ--IPGEKIFENIRNLELPLCPYCYQKRKQYFPMSNGNNTVQTNINFNS 370
Query: 154 -----GSLLRPDVVWFGEPLPREELDRAFKLAEKADAVLVVGTSGLVYPAAYIPYIV 205
+L+PD+ +FGE LP K + D ++ +GTS V P + I +V
Sbjct: 371 PILKSYGVLKPDMTFFGEALPSRFHKTIRKDILECDLLICIGTSLKVAPVSEIVNMV 427
>pir||T39571 probable regulatory protein sir2-like - fission yeast
(Schizosaccharomyces pombe) >gi|4495125|emb|CAB38511.2|
(AL035637) putative regulatory protein sir2-like
[Schizosaccharomyces pombe]
Length = 471
Score = 77.6 bits (188), Expect = 1e-13
Identities = 56/245 (22%), Positives = 104/245 (41%), Gaps = 47/245 (19%)
Query: 4 EVARVLASSKNAIAFTGAGISAESGVPTFRGKDGLWNKY------RPEELATPEAFARNP 57
+V +L +KN + GAGIS G+ FR +G + + P E+ F NP
Sbjct: 144 DVVNLLKKAKNVVVLVGAGISTSLGILDFRSDNGFYARLARHGLSEPSEMFDIHTFRENP 203
Query: 58 KLVWEFYKWRINKILKAKPNPAHYALVELEDMGILRAVITQNVDDLHREAG--TRNLIEL 115
++ + F + + + P+ A L+E ++ L + TQN+D+L ++ G +I+
Sbjct: 204 EIFYTFARDLLPETNHYSPSHAFIRLLEKKNK--LSTLFTQNIDNLEKKTGLSDNKIIQC 261
Query: 116 HGNIFRVKCTKCNFKEYLKESQRLEEVLKEDLPKCPRCG--------------------- 154
HG+ C KC K + S+ E++ + + C CG
Sbjct: 262 HGSFATATCIKCKHK--VDGSELYEDIRNQRVSYCNECGKPPLKLRRVGQNKKEKHYFSD 319
Query: 155 -------------SLLRPDVVWFGEPLPREELDRAFK-LAEKADAVLVVGTSGLVYPAAY 200
+++PD+ +FGE LP ++ E+ D ++ +GTS V P +
Sbjct: 320 GDSESSEDDLAQPGIMKPDITFFGEALPDSFFNKVGSGELEETDLLICIGTSLKVAPVSE 379
Query: 201 IPYIV 205
+ ++
Sbjct: 380 LISVI 384
>gb|AAF56851.2| (AE003768) CG11305 gene product [Drosophila melanogaster]
Length = 771
Score = 75.7 bits (183), Expect = 5e-13
Identities = 62/257 (24%), Positives = 110/257 (42%), Gaps = 36/257 (14%)
Query: 2 IVEVARVLASSKNAIAFTGAGISAESGVPTFRGKDGLWNKYRPEELATPEAFARNPKLVW 61
+ ++A +++ +K+ + +TGAGIS + +P +RG G+W L+
Sbjct: 113 VEQLANIISQAKHLVCYTGAGISTAALIPDYRGSQGIWT------------------LLQ 154
Query: 62 EFYKWRINKILKAKPNPAHYALVELEDMGILRAVITQNVDDLHREAG--TRNLIELHGNI 119
+ + + A P H AL EL +L V++QN D LH +G +L E+HGN+
Sbjct: 155 KGQDIGEHDLSSANPTYTHMALYELHRRRLLHHVVSQNCDGLHLRSGLPRNSLSEIHGNM 214
Query: 120 FRVKCTKCN----FKEYLKESQRLEEVLKEDLPKCPRCGSLLRPDVVWFGE------PLP 169
+ C C + ++ + C RC L +V FGE PL
Sbjct: 215 YVEVCKNCRPNSVYWRQFDTTEMTARYCHKTHRLCHRCSEPLYDTIVHFGERGNVKWPL- 273
Query: 170 REELDRAFKLAEKADAVLVVGTSGLV---YPAAYIPYIVKESGGTVIEVNVEESAITPIA 226
A A++AD +L +G+S V Y + + VN++ + IA
Sbjct: 274 --NWAGATANAQRADVILCLGSSLKVLKKYTWLWQMDRPARQRAKICVVNLQWTPKDAIA 331
Query: 227 DFFLRGRAGEVLPRVVH 243
+ G+ +V+ +++H
Sbjct: 332 SIKINGKCDQVMAQLMH 348
>gi|6324599 involved in telomeric silencing; Hst3p [Saccharomyces cerevisiae]
>gi|1708327|sp|P53687|HST3_YEAST HST3 PROTEIN
(HOMOLOGOUS TO SIR2 PROTEIN 3) >gi|1078372|pir||S54631
HST3 protein - yeast (Saccharomyces cerevisiae)
>gi|829135|emb|CAA60741.1| (X87331) encodes homologue of
yeast SIR2 (controlling mating type); overlaps with
X01419 [Saccharomyces cerevisiae]
>gi|1055022|gb|AAA81034.1| (U39062) Hst3p [Saccharomyces
cerevisiae] >gi|1420135|emb|CAA99215.1| (Z74933) ORF
YOR025w [Saccharomyces cerevisiae]
Length = 447
Score = 73.0 bits (176), Expect = 3e-12
Identities = 71/284 (25%), Positives = 117/284 (41%), Gaps = 61/284 (21%)
Query: 5 VARVLASSKNAIAFTGAGISAESGVPTFRGKDGL-----------WNKYRPEELATPEAF 53
V + L+ S+ TGAGIS +G+P FR DGL W+ E+ F
Sbjct: 45 VTKQLSRSRRIACLTGAGISCNAGIPDFRSSDGLYDLVKKDCSQYWSIKSGREMFDISLF 104
Query: 54 ARNPK--LVWEFYKWRINKILKAKPNPAHYALVELEDMGILRAVITQNVDDLHREAG--- 108
+ K + +F + + + AKP H + L+D L TQN+D L G
Sbjct: 105 RDDFKISIFAKFMERLYSNVQLAKPTKTHKFIAHLKDRNKLLRCYTQNIDGLEESIGLTL 164
Query: 109 ---------------TRNLIELHGNIFRVKCTKCNFKEYLKESQRLEEVLKEDLPKCPRC 153
++++LHG++ + CTKC F+ + + + +LP CP C
Sbjct: 165 SNRKLPLTSFSSHWKNLDVVQLHGDLKTLSCTKC-FQTFPWSRYWSRCLRRGELPLCPDC 223
Query: 154 GSL------------------LRPDVVWFGEPLPR-EELDRAFKL---AEKADAVLVVGT 191
+L LRP++V +GE P E + + L D ++++GT
Sbjct: 224 EALINKRLNEGKRTLGSNVGILRPNIVLYGENHPSCEIITQGLNLDIIKGNPDFLIIMGT 283
Query: 192 S----GLVYPAAYIPYIVKESGGTVIEVN---VEESAITPIADF 228
S G+ + + + GG +I VN + ES+ I D+
Sbjct: 284 SLKVDGVKQLVKKLSKKIHDRGGLIILVNKTPIGESSWHGIIDY 327
>gb|AAF67015.1|AF160214_1 (AF160214) silent information regulator 2 homolog [Homo sapiens]
Length = 373
Score = 68.3 bits (164), Expect = 9e-11
Identities = 60/208 (28%), Positives = 90/208 (42%), Gaps = 17/208 (8%)
Query: 5 VARVLASSK--NAIAFTGAGISAESGVPTFRGKD-GLWNKYRPEELATPEA------FAR 55
VAR + S + I GAGIS +G+P FR GL++ L PEA F +
Sbjct: 51 VARYMQSERCRRVICLVGAGISTSAGIPDFRSPSTGLYDNLEKYHLPYPEAIFEISYFKK 110
Query: 56 NPKLVWEFYKWRINKILKAKPNPAHYALVEL--EDMGILRAVI--TQNVDDLHREAGTRN 111
+P+ + K ++ + H +L+ E G A++ + AGT
Sbjct: 111 HPEPFFALAK----ELYPGQFQANHLSLLHAPAEGQGATPALLHAEHRYPGANSRAGTGG 166
Query: 112 LIELHGNIFRVKCTKCNFKEYLKESQRLEEVLKEDLPKCPRCGSLLRPDVVWFGEPLPRE 171
L ++ + N + S E++ E PKC C SL++PD+V+FGE LP
Sbjct: 167 LGGGARHLLHITLRHANCRHEYPLSWMKEKIFSEVTPKCEDCQSLVKPDIVFFGESLPAR 226
Query: 172 ELDRAFKLAEKADAVLVVGTSGLVYPAA 199
K D +LV+GTS V P A
Sbjct: 227 FFSCMQSDFLKVDLLLVMGTSLQVQPFA 254
Database: ./suso.pep
Posted date: Jul 6, 2001 5:57 PM
Number of letters in database: 840,471
Number of sequences in database: 2977
Database: /banques/blast2/nr.pep
Posted date: Dec 14, 2000 12:46 PM
Number of letters in database: 188,266,275
Number of sequences in database: 595,510
Lambda K H
0.320 0.139 0.413
Gapped
Lambda K H
0.270 0.0470 0.230
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 94674043
Number of Sequences: 2977
Number of extensions: 4070011
Number of successful extensions: 10758
Number of sequences better than 1.0e-10: 70
Number of HSP's better than 0.0 without gapping: 22
Number of HSP's successfully gapped in prelim test: 48
Number of HSP's that attempted gapping in prelim test: 10559
Number of HSP's gapped (non-prelim): 78
length of query: 250
length of database: 189,106,746
effective HSP length: 53
effective length of query: 197
effective length of database: 157,386,935
effective search space: 31005226195
effective search space used: 31005226195
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 41 (21.8 bits)
S2: 164 (68.3 bits)