BLASTP 2.0.10 [Aug-26-1999]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= PAB0829 (purB) DE:adenylosuccinate lyase (purB)
(450 letters)
Database: ./suso.pep; /banques/blast2/nr.pep
598,487 sequences; 189,106,746 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9UZ99|PUR8_PYRAB ADENYLOSUCCINATE LYASE (ADENYLOSUCCINASE) (... 888 0.0
sp|O58582|PUR8_PYRHO ADENYLOSUCCINATE LYASE (ADENYLOSUCCINASE) (... 829 0.0
sp|Q58339|PUR8_METJA ADENYLOSUCCINATE LYASE (ADENYLOSUCCINASE) (... 521 e-147
sp|O27580|PUR8_METTH ADENYLOSUCCINATE LYASE (ADENYLOSUCCINASE) (... 510 e-143
gi|11499824 adenylosuccinate lyase (purB) [Archaeoglobus fulgidu... 464 e-129
sp|O66856|PUR8_AQUAE ADENYLOSUCCINATE LYASE (ADENYLOSUCCINASE) (... 390 e-107
gb|AAK40580.1| Adenylosuccinate lyase (adenylosuccinase)(ASL) (p... 381 e-105
dbj|BAB04344.1| (AP001509) adenylosuccinate lyase [Bacillus halo... 357 1e-97
sp|P12047|PUR8_BACSU ADENYLOSUCCINATE LYASE (ADENYLOSUCCINASE) (... 345 7e-94
emb|CAC11663.1| (AL445064) probable adenylosuccinate lyase [Ther... 342 6e-93
sp|P56468|PUR8_HELPY ADENYLOSUCCINATE LYASE (ADENYLOSUCCINASE) (... 336 3e-91
sp|P74384|PUR8_SYNY3 ADENYLOSUCCINATE LYASE (ADENYLOSUCCINASE) (... 330 2e-89
sp|Q9ZKA2|PUR8_HELPJ ADENYLOSUCCINATE LYASE (ADENYLOSUCCINASE) (... 329 5e-89
pdb|1C3C|A Chain A, T. Maritima Adenylosuccinate Lyase >gi|72458... 324 2e-87
sp|Q9X0I0|PUR8_THEMA ADENYLOSUCCINATE LYASE (ADENYLOSUCCINASE) (... 324 2e-87
pir||B81418 adenylosuccinate lyase (EC 4.3.2.2) Cj0023 [imported... 307 2e-82
sp|Q9RSE6|PUR8_DEIRA ADENYLOSUCCINATE LYASE (ADENYLOSUCCINASE) (... 295 5e-79
pir||D81284 probable fumarate lyase Cj1394 [imported] - Campylob... 282 5e-75
pir||G83205 probable lyase PA3517 [imported] - Pseudomonas aerug... 264 1e-69
pir||T39170 probable cis-muconate cycloisomerase [imported] - fi... 254 2e-66
pir||B83616 3-carboxy-cis,cis-muconate cycloisomerase PA0230 [im... 238 9e-62
gb|AAD39559.1| (AF031417) PcaB-like protein [Pseudomonas putida] 235 1e-60
pir||F83205 probable lyase PA3516 [imported] - Pseudomonas aerug... 217 2e-55
gi|7705660 surfactant protein B [Homo sapiens] >gi|1220355|gb|AA... 212 7e-54
dbj|BAA99412.1| (AB036769) exfoliative toxin C [Staphylococcus a... 207 2e-52
sp|Q59092|PCAB_ACICA 3-CARBOXY-CIS,CIS-MUCONATE CYCLOISOMERASE (... 202 8e-51
gi|6323391 Adenylosuccinate Lyase; Ade13p [Saccharomyces cerevis... 201 2e-50
gb|AAC83935.1| (AF106656) adenylosuccinate lyase [Homo sapiens] 200 2e-50
gi|6752996 adenylosuccinate lyase [Mus musculus] >gi|1709933|sp|... 199 4e-50
gi|4557269 adenylosuccinate lyase; adenylosuccinase [Homo sapien... 199 4e-50
sp|O31385|PCAB_BRAJA 3-CARBOXY-CIS,CIS-MUCONATE CYCLOISOMERASE (... 198 1e-49
sp|P32427|PCAB_PSEPU 3-CARBOXY-CIS,CIS-MUCONATE CYCLOISOMERASE (... 197 3e-49
pir||I58109 adenylosuccinate lyase - human >gi|28905|emb|CAA4669... 190 3e-47
sp|P21265|PUR8_CHICK ADENYLOSUCCINATE LYASE (ADENYLOSUCCINASE) (... 189 4e-47
pir||T47114 probable 3-carboxy-cis,cis-muconate cycloisomerase (... 189 4e-47
gb|AAC21561.1| (AF067854) adenylosuccinate lyase [Homo sapiens] ... 185 8e-46
gb|AAF55375.1| (AE003715) CG3590 gene product [Drosophila melano... 185 1e-45
sp|O60105|PUR8_SCHPO ADENYLOSUCCINATE LYASE (ADENYLOSUCCINASE) (... 183 3e-45
pir||T35016 probable 3-carboxy-cis,cis-muconate cycloisomerase -... 162 9e-39
pir||T23969 hypothetical protein R06C7.5 - Caenorhabditis elegan... 160 3e-38
pir||D70708 probable purB protein - Mycobacterium tuberculosis (... 150 3e-35
dbj|BAA89447.1| (AB003161) adenylosuccino lyase [Corynebacterium... 148 9e-35
emb|CAB08409.1| (Z95151) PurB [Mycobacterium leprae] 146 6e-34
gb|AAC38245.1| (AF003947) 3-carboxy-cis,cis-muconate cycloisomer... 140 3e-32
gb|AAC38208.1| (AF021092) adenylosuccinate lyase [Helicobacter p... 125 1e-27
gb|AAD28329.1|AF080446_2 (AF080446) adenylosuccinate lyase [Plas... 123 3e-27
pir||F83317 adenylosuccinate lyase PA2629 [imported] - Pseudomon... 122 1e-26
pir||A82237 adenylosuccinate lyase VC1126 [imported] - Vibrio ch... 117 3e-25
gb|AAA92731.1| (M74924) adenylosuccinate lyase [Escherichia coli] 115 8e-25
sp|P25739|PUR8_ECOLI ADENYLOSUCCINATE LYASE (ADENYLOSUCCINASE) (... 115 1e-24
emb|CAB99134.1| (AL390188) putative adenylosuccino lyase (fragme... 113 4e-24
gb|AAG18966.1| (AE004997) adenylosuccinate lyase; PurB [Halobact... 108 1e-22
pir||A43307 adenylosuccinate lyase - Escherichia coli 107 3e-22
gb|AAF34266.1| (U32867) 3-carboxy-cis,cis-muconate cycloisomeras... 106 4e-22
sp|O26369|ARLY_METTH ARGININOSUCCINATE LYASE (ARGINOSUCCINASE) (... 105 1e-21
pir||F71618 adenylosuccinate lyase (OO) PFB0295w - malaria paras... 102 1e-20
pir||D81216 adenylosuccinate lyase NMB0284 [imported] - Neisseri... 101 1e-20
pir||C81930 probable argininosuccinate lyase (EC 4.3.2.1) NMA084... 101 1e-20
pir||B81175 argininosuccinate lyase NMB0637 [imported] - Neisser... 101 2e-20
pir||D82666 adenylosuccinate lyase XF1553 [imported] - Xylella f... 101 2e-20
pir||F81793 adenylosuccinate lyase (EC 4.3.2.2) NMA2203 [importe... 100 4e-20
sp|O67383|ARLY_AQUAE ARGININOSUCCINATE LYASE (ARGINOSUCCINASE) (... 99 7e-20
sp|P44797|PUR8_HAEIN ADENYLOSUCCINATE LYASE (ADENYLOSUCCINASE) (... 99 1e-19
pir||D64083 adenylosuccinate lyase (EC 4.3.2.2) - Haemophilus in... 99 1e-19
gb|AAF66620.1|AF143209_1 (AF143209) argininosuccinate lyase [Nos... 98 2e-19
sp|P57351|PUR8_BUCAI ADENYLOSUCCINATE LYASE (ADENYLOSUCCINASE) (... 96 8e-19
sp|Q58201|ARLY_METJA ARGININOSUCCINATE LYASE (ARGINOSUCCINASE) (... 95 1e-18
sp|P05083|CRD2_CHICK DELTA CRYSTALLIN II (ARGININOSUCCINATE LYAS... 93 7e-18
pir||CYDKD2 delta-2-crystallin - duck 91 2e-17
gb|AAG21593.1|AC025781_1 (AC025781) adenylosuccinate lyase-like ... 91 2e-17
emb|CAB59872.1| (AL132764) adenylosuccinate lyase [Leishmania ma... 91 3e-17
sp|Q46104|ARLY_CAMJE ARGININOSUCCINATE LYASE (ARGINOSUCCINASE) (... 91 3e-17
sp|P24058|CRD2_ANAPL DELTA CRYSTALLIN II (ARGININOSUCCINATE LYAS... 90 3e-17
sp|P50514|ARLZ_SCHPO PROBABLE ARGININOSUCCINATE LYASE (ARGINOSUC... 89 1e-16
sp|Q01592|CRD1_COLLI DELTA CRYSTALLIN (ARGININOSUCCINATE LYASE >... 88 2e-16
dbj|BAB06905.1| (AP001518) argininosuccinate lyase [Bacillus hal... 88 2e-16
gb|AAB70982.1| (AF025459) Contains similarity to Pfam domain: PF... 87 3e-16
pdb|1AUW|A Chain A, H91n Delta 2 Crystallin From Duck >gi|298171... 86 7e-16
sp|P24057|CRD1_ANAPL DELTA CRYSTALLIN I >gi|68369|pir||CYDKD1 de... 85 1e-15
sp|P33110|CRD1_ANSAN DELTA CRYSTALLIN (ARGININOSUCCINATE LYASE >... 85 2e-15
gb|AAA93048.1| (M77188) argininosuccinate lyase [Campylobacter j... 84 3e-15
pir||S32580 argininosuccinate lyase (EC 4.3.2.1) - fission yeast... 83 8e-15
gb|AAF43427.1|AF233374_1 (AF233374) argininosuccinate lyase [Vol... 83 8e-15
sp|P40369|ARLY_SCHPO ARGININOSUCCINATE LYASE (ARGINOSUCCINASE) (... 82 1e-14
prf||2105196A argininosuccinate lyase [Rana catesbeiana] 80 4e-14
sp|P73257|ARLY_SYNY3 ARGININOSUCCINATE LYASE (ARGINOSUCCINASE) (... 80 4e-14
emb|CAB76090.1| (AL157956) argininosuccinate lyase [Streptomyces... 80 4e-14
sp|P02521|CRD1_CHICK DELTA CRYSTALLIN I >gi|68371|pir||CYCHD del... 80 5e-14
emb|CAA25260.1| (X00626) delta-crystallin [Gallus gallus] >gi|45... 79 9e-14
sp|P51464|ARLY_RANCA ARGININOSUCCINATE LYASE (ARGINOSUCCINASE) (... 79 9e-14
pir||S52133 argininosuccinate lyase (EC 4.3.2.1) - bullfrog 79 9e-14
gb|AAA48728.1| (J00843) delta-crystallin mRNA [Gallus gallus] 78 1e-13
pir||UFBSC8 fumarate hydratase (EC 4.2.1.2) - Bacillus subtilis ... 78 2e-13
sp|P07343|FUMH_BACSU FUMARATE HYDRATASE, CLASS-II (FUMARASE) >gi... 78 2e-13
pir||T39679 argininosuccinate lyase - fission yeast (Schizosacch... 78 2e-13
gi|11024648 argininosuccinate lyase [Rattus norvegicus] >gi|1141... 78 3e-13
pir||B75250 fumarate hydratase - Deinococcus radiodurans (strain... 77 3e-13
dbj|BAB05145.1| (AP001512) aspartate ammonia-lyase [Bacillus hal... 77 3e-13
sp|P57159|ARLY_BUCAI ARGININOSUCCINATE LYASE (ARGINOSUCCINASE) (... 77 4e-13
gi|8393358 fumarate hydratase [Rattus norvegicus] >gi|120605|sp|... 76 6e-13
prf||1709138A fumarase [Rattus norvegicus] 76 6e-13
sp|P11447|ARLY_ECOLI ARGININOSUCCINATE LYASE (ARGINOSUCCINASE) (... 76 6e-13
pir||T43727 fumarate hydratase (EC 4.2.1.2) [imported] - Thermus... 76 6e-13
sp|O34858|ARLY_BACSU ARGININOSUCCINATE LYASE (ARGINOSUCCINASE) (... 76 1e-12
emb|CAB88663.1| (AJ277474) argininosuccinate lyase [Agaricus bis... 76 1e-12
dbj|BAA03088.1| (D13978) argininosuccinate lyase [Rattus sp.] >g... 75 2e-12
sp|Q9Z660|ARLY_ZYMMO ARGININOSUCCINATE LYASE (ARGINOSUCCINASE) (... 75 2e-12
sp|P22675|ARLY_CHLRE ARGININOSUCCINATE LYASE (ARGINOSUCCINASE) (... 74 3e-12
emb|CAA09001.1| (AJ010110) argininosuccinate lyase [Chlamydomona... 74 3e-12
pir||T45269 fumarate hydratase (EC 4.2.1.2) [imported] - Thermus... 74 4e-12
pir||E82989 argininosuccinate lyase PA5263 [imported] - Pseudomo... 74 4e-12
sp|P26899|ASPA_BACSU ASPARTATE AMMONIA-LYASE (ASPARTASE) >gi|682... 73 5e-12
sp|P56149|ASPA_HELPY ASPARTATE AMMONIA-LYASE (ASPARTASE) >gi|743... 73 5e-12
emb|CAA88927.2| (Z49111) argininosuccinate lyase [Streptomyces c... 73 5e-12
emb|CAB10698.1| (Z97558) argininosuccinate lyase [Arabidopsis th... 73 8e-12
pir||T50801 argininosuccinate lyase (AtArgH) - Arabidopsis thali... 73 8e-12
sp|Q9ZLI5|ASPA_HELPJ ASPARTATE AMMONIA-LYASE (ASPARTASE) >gi|743... 72 1e-11
gb|AAF52721.1| (AE003623) CG9510 gene product [Drosophila melano... 72 1e-11
sp|P07954|FUMH_HUMAN FUMARATE HYDRATASE, MITOCHONDRIAL PRECURSOR... 71 2e-11
dbj|BAB08741.1| (AB017063) fumarate hydratase [Arabidopsis thali... 71 2e-11
sp|P05042|FUMC_ECOLI FUMARATE HYDRATASE CLASS II (FUMARASE) >gi|... 70 4e-11
sp|P43061|ARLY_CANAL ARGININOSUCCINATE LYASE (ARGINOSUCCINASE) (... 70 4e-11
pdb|1FUQ|A Chain A, Fumarase With Bound Pyromellitic Acid >gi|19... 70 4e-11
pdb|2FUS|A Chain A, Mutations Of Fumarase That Distinguish Betwe... 70 4e-11
emb|CAB95018.1| (AJ252020) argininosuccinase and n-acetylglutama... 70 6e-11
pir||T00433 fumarate hydratase (EC 4.2.1.2) - Arabidopsis thalia... 69 7e-11
sp|O74026|ARLY_METMP ARGININOSUCCINATE LYASE (ARGINOSUCCINASE) (... 69 7e-11
sp|P55250|FUMH_RHIOR FUMARATE HYDRATASE PRECURSOR (FUMARASE) >gi... 69 7e-11
pir||JC4293 fumarate hydratase (EC 4.2.1.2) precursor - Rhizopus... 69 7e-11
gb|AAB97818.1| (AF013216) fumarate hydratase [Myxococcus xanthus] 69 7e-11
gb|AAF00228.1|AF173956_1 (AF173956) argininosuccinate lyase [Clo... 69 1e-10
dbj|BAA93044.1| (AB028242) aspartase [Bacillus sp. YM55-1] 69 1e-10
gb|AAF46186.2| (AE003438) CG4094 gene product [Drosophila melano... 69 1e-10
gi|11428234 similar to argininosuccinate lyase (H. sapiens) [Hom... 69 1e-10
>sp|Q9UZ99|PUR8_PYRAB ADENYLOSUCCINATE LYASE (ADENYLOSUCCINASE) (ASL)
>gi|7436843|pir||C75033 adenylosuccinate lyase (purb)
PAB0829 - Pyrococcus abyssi (strain Orsay)
>gi|5458673|emb|CAB50160.1| (AJ248287) adenylosuccinate
lyase (purB) [Pyrococcus abyssi]
Length = 450
Score = 888 bits (2269), Expect = 0.0
Identities = 450/450 (100%), Positives = 450/450 (100%)
Query: 1 MAVHPIDYRYGSEEMRRVWEEENKLQKLLDVEAALARAHAKLGNIPEESARVISERANTK 60
MAVHPIDYRYGSEEMRRVWEEENKLQKLLDVEAALARAHAKLGNIPEESARVISERANTK
Sbjct: 1 MAVHPIDYRYGSEEMRRVWEEENKLQKLLDVEAALARAHAKLGNIPEESARVISERANTK 60
Query: 61 WVKLERVKEIEAEIHHDIMAVVKALSEVCGEHGKYVHLGATSNDIIDTANALLIKESLAI 120
WVKLERVKEIEAEIHHDIMAVVKALSEVCGEHGKYVHLGATSNDIIDTANALLIKESLAI
Sbjct: 61 WVKLERVKEIEAEIHHDIMAVVKALSEVCGEHGKYVHLGATSNDIIDTANALLIKESLAI 120
Query: 121 VEKDLKELRSILKELAKKHIDTVCIGRTHGQHAVPTTYGMKFALWLDEIQRHIERLQQLK 180
VEKDLKELRSILKELAKKHIDTVCIGRTHGQHAVPTTYGMKFALWLDEIQRHIERLQQLK
Sbjct: 121 VEKDLKELRSILKELAKKHIDTVCIGRTHGQHAVPTTYGMKFALWLDEIQRHIERLQQLK 180
Query: 181 DRVLVGKMRGAVGTAASFGDKAFEIEKLVMEDLGLKPARITNQIIQRDVYAELMFFLALV 240
DRVLVGKMRGAVGTAASFGDKAFEIEKLVMEDLGLKPARITNQIIQRDVYAELMFFLALV
Sbjct: 181 DRVLVGKMRGAVGTAASFGDKAFEIEKLVMEDLGLKPARITNQIIQRDVYAELMFFLALV 240
Query: 241 ASTLDKMALEIRNLQRTEILEVSEPFGEKQVGSSTMPHKRNPIRTEKVCGLARVLYSNVI 300
ASTLDKMALEIRNLQRTEILEVSEPFGEKQVGSSTMPHKRNPIRTEKVCGLARVLYSNVI
Sbjct: 241 ASTLDKMALEIRNLQRTEILEVSEPFGEKQVGSSTMPHKRNPIRTEKVCGLARVLYSNVI 300
Query: 301 PALLNNPLWHERDLTNSSVERVILPESFVLLDEMLKVMKKVLKGLEFFPENIKRNLYLTK 360
PALLNNPLWHERDLTNSSVERVILPESFVLLDEMLKVMKKVLKGLEFFPENIKRNLYLTK
Sbjct: 301 PALLNNPLWHERDLTNSSVERVILPESFVLLDEMLKVMKKVLKGLEFFPENIKRNLYLTK 360
Query: 361 NLIMAEPLMLKLAEKGMGRQEAHELVRQLAMKAFKEGRDLLEVVRKNEEAMKYLTENDLE 420
NLIMAEPLMLKLAEKGMGRQEAHELVRQLAMKAFKEGRDLLEVVRKNEEAMKYLTENDLE
Sbjct: 361 NLIMAEPLMLKLAEKGMGRQEAHELVRQLAMKAFKEGRDLLEVVRKNEEAMKYLTENDLE 420
Query: 421 GLKPENYIGKAREIVENVVNYVEEMERRGL 450
GLKPENYIGKAREIVENVVNYVEEMERRGL
Sbjct: 421 GLKPENYIGKAREIVENVVNYVEEMERRGL 450
>sp|O58582|PUR8_PYRHO ADENYLOSUCCINATE LYASE (ADENYLOSUCCINASE) (ASL)
>gi|7436838|pir||H71135 probable adenylosuccinate lyase
- Pyrococcus horikoshii >gi|3257263|dbj|BAA29946.1|
(AP000003) 450aa long hypothetical adenylosuccinate
lyase [Pyrococcus horikoshii]
Length = 450
Score = 829 bits (2117), Expect = 0.0
Identities = 413/450 (91%), Positives = 435/450 (95%)
Query: 1 MAVHPIDYRYGSEEMRRVWEEENKLQKLLDVEAALARAHAKLGNIPEESARVISERANTK 60
MAVHPIDYRYGSEEMR++W+E+NKLQKLLDVEAALARAHAK+GNIPEESA+VISERANTK
Sbjct: 1 MAVHPIDYRYGSEEMRKIWDEKNKLQKLLDVEAALARAHAKVGNIPEESAKVISERANTK 60
Query: 61 WVKLERVKEIEAEIHHDIMAVVKALSEVCGEHGKYVHLGATSNDIIDTANALLIKESLAI 120
WVKLERVKEIEAEIHHDIMAVVKALSEVCGEHGKYVHLGATSNDIIDTANALLIKESL I
Sbjct: 61 WVKLERVKEIEAEIHHDIMAVVKALSEVCGEHGKYVHLGATSNDIIDTANALLIKESLEI 120
Query: 121 VEKDLKELRSILKELAKKHIDTVCIGRTHGQHAVPTTYGMKFALWLDEIQRHIERLQQLK 180
VE+DLKELRSILK+LA+KHI TVCIGRTHGQHAVPTTYGMKFALWLDEIQRHIERL QLK
Sbjct: 121 VERDLKELRSILKQLAEKHIGTVCIGRTHGQHAVPTTYGMKFALWLDEIQRHIERLYQLK 180
Query: 181 DRVLVGKMRGAVGTAASFGDKAFEIEKLVMEDLGLKPARITNQIIQRDVYAELMFFLALV 240
+RVLVGKMRGAVGTAASFG+KAFEIE+LVMEDLGLKPARITNQI+QRDVYAEL+FFLALV
Sbjct: 181 ERVLVGKMRGAVGTAASFGEKAFEIERLVMEDLGLKPARITNQIVQRDVYAELLFFLALV 240
Query: 241 ASTLDKMALEIRNLQRTEILEVSEPFGEKQVGSSTMPHKRNPIRTEKVCGLARVLYSNVI 300
ASTLDKM LEIRNLQRTEILEVSEPFGEKQVGSSTMPHKRNPIRTEKVCGLARVLYSNVI
Sbjct: 241 ASTLDKMGLEIRNLQRTEILEVSEPFGEKQVGSSTMPHKRNPIRTEKVCGLARVLYSNVI 300
Query: 301 PALLNNPLWHERDLTNSSVERVILPESFVLLDEMLKVMKKVLKGLEFFPENIKRNLYLTK 360
PALLNNPLWHERDLTNSSVERVILPESFVLLDEMLK MKKVL GLEFFPENI+RNLYLTK
Sbjct: 301 PALLNNPLWHERDLTNSSVERVILPESFVLLDEMLKTMKKVLTGLEFFPENIRRNLYLTK 360
Query: 361 NLIMAEPLMLKLAEKGMGRQEAHELVRQLAMKAFKEGRDLLEVVRKNEEAMKYLTENDLE 420
NLIMAEPLMLKLAEKGMGRQEAHE+VRQLAMKAF+E RDLLEV +++ E KYLTE DLE
Sbjct: 361 NLIMAEPLMLKLAEKGMGRQEAHEVVRQLAMKAFRENRDLLEVAKESREITKYLTERDLE 420
Query: 421 GLKPENYIGKAREIVENVVNYVEEMERRGL 450
LKPENYIGKAREIV+ V+ YVEEMERRGL
Sbjct: 421 ELKPENYIGKAREIVKKVIEYVEEMERRGL 450
>sp|Q58339|PUR8_METJA ADENYLOSUCCINATE LYASE (ADENYLOSUCCINASE) (ASL)
>gi|2127747|pir||A64416 adenylosuccinate lyase (EC
4.3.2.2) - Methanococcus jannaschii
>gi|1591600|gb|AAB98931.1| (U67536) adenylosuccinate
lyase (purB) [Methanococcus jannaschii]
Length = 462
Score = 521 bits (1328), Expect = e-147
Identities = 261/442 (59%), Positives = 345/442 (78%), Gaps = 3/442 (0%)
Query: 1 MAVHPIDYRYGSEEMRRVWEEENKLQKLLDVEAALARAHAKLGNIPEESARVISERANTK 60
MAVHPIDYRYG+ EMR+VWEEENKL+K+L VEAALA+A A+LG IP+E+A I+++A+TK
Sbjct: 13 MAVHPIDYRYGTPEMRKVWEEENKLEKMLKVEAALAKAQAELGLIPKEAAEEINKKASTK 72
Query: 61 WVKLERVKEIEAEIHHDIMAVVKALSEVC-GEHGKYVHLGATSNDIIDTANALLIKESLA 119
+VKLERVKEIE + HD++A+++AL+EVC G G+Y+H GATSNDI+DTAN+LLIKES+
Sbjct: 73 YVKLERVKEIEKQTKHDVVAMIRALAEVCEGNAGEYIHFGATSNDIVDTANSLLIKESIE 132
Query: 120 IVEKDLKELRSILKELAKKHIDTVCIGRTHGQHAVPTTYGMKFALWLDEIQRHIERLQQL 179
I+E LK+LR IL + A++H TVC+GRTHGQHA+PTTYGM+FALW EI RH+ERL++
Sbjct: 133 IIEDKLKQLRDILLDKAEEHKYTVCVGRTHGQHAIPTTYGMRFALWAAEIDRHLERLKEA 192
Query: 180 KDRVLVGKMRGAVGTAASFGDKAFEIEKLVMEDLGLKPARITNQIIQRDVYAELMFFLAL 239
K R+ V + GAVGT A+ G+K E+ K V E LGL+P I+NQ+IQRD +AE +F LAL
Sbjct: 193 KKRICVSMITGAVGTMAAMGEKGLEVHKRVAEILGLEPVLISNQVIQRDRHAEFVFLLAL 252
Query: 240 VASTLDKMALEIRNLQRTEILEVSEPFG-EKQVGSSTMPHKRNPIRTEKVCGLARVLYSN 298
+A TL+K+ + +R++QRTEI E+ E F KQ GSSTMPHKRNPI E++CGL+RV+ S
Sbjct: 253 IAQTLNKIGVTVRSMQRTEIGELEEEFDPTKQTGSSTMPHKRNPITFEQICGLSRVIKSL 312
Query: 299 VIPALLNNPLWHERDLTNSSVERVILPESFVLLDEMLKVMKKVLKGLEFFPENIKRNLYL 358
I + N PLW ERDLTNSS ER I E VL D +L + K +K L+ EN++RNL L
Sbjct: 313 CIAEMDNIPLWEERDLTNSSAERCIFAEVCVLTDHILTLAIKGVKKLKVNKENVERNLEL 372
Query: 359 TKNLIMAEPLMLKLAEKGMGRQEAHELVRQLAMKAFKEGRDLLEVVRKNEEAMKYLTEND 418
TK LIMAE +M++LA++GMGRQ AHE+VRQ AMKA++E R L +++ +NEE MKY+T+ +
Sbjct: 373 TKGLIMAERIMIELAKRGMGRQTAHEIVRQCAMKAYEEKRHLKDILLENEEVMKYITKEE 432
Query: 419 LEGL-KPENYIGKAREIVENVV 439
LE L P+ YIG A +IV+ V+
Sbjct: 433 LEELMNPKTYIGLAPQIVDEVI 454
>sp|O27580|PUR8_METTH ADENYLOSUCCINATE LYASE (ADENYLOSUCCINASE) (ASL)
>gi|7436839|pir||A69072 adenylosuccinate lyase -
Methanobacterium thermoautotrophicum (strain Delta H)
>gi|2622657|gb|AAB86011.1| (AE000914) adenylosuccinate
lyase [Methanobacterium thermoautotrophicum]
Length = 449
Score = 510 bits (1298), Expect = e-143
Identities = 257/442 (58%), Positives = 333/442 (75%), Gaps = 3/442 (0%)
Query: 1 MAVHPIDYRYGSEEMRRVWEEENKLQKLLDVEAALARAHAKLGNIPEESARVISERANTK 60
MA+HP+++RYG+ EMR +WE ENKLQK+LDVEAALA+A +LG IP E+A I +A+T+
Sbjct: 1 MAIHPVEFRYGTPEMRVIWEAENKLQKMLDVEAALAQAEGELGIIPAEAASEIVRKASTE 60
Query: 61 WVKLERVKEIEAEIHHDIMAVVKALSEVC-GEHGKYVHLGATSNDIIDTANALLIKESLA 119
+V LERV EIE + HDI ++VKAL+E C G+ G+YVH GATSNDI+DT+N+LL+++S++
Sbjct: 61 FVTLERVNEIERDTKHDIASLVKALAEQCEGDAGEYVHFGATSNDIVDTSNSLLLRDSIS 120
Query: 120 IVEKDLKELRSILKELAKKHIDTVCIGRTHGQHAVPTTYGMKFALWLDEIQRHIERLQQL 179
++ L + +L LA ++ D VCIGRTHGQHA+PTTYGMKFA+W DEI R +ERL
Sbjct: 121 VLRDKLTRVLEVLLALADENRDRVCIGRTHGQHALPTTYGMKFAIWADEIHRQLERLDAC 180
Query: 180 KDRVLVGKMRGAVGTAASFGDKAFEIEKLVMEDLGLKPARITNQIIQRDVYAELMFFLAL 239
+R+ VG M GAVGT A+ G++ E+ + V E LGL+P I+NQ++QRD +AE + LA
Sbjct: 181 SERLCVGMMTGAVGTTAALGEEGLEVHERVSEILGLRPVLISNQVVQRDNHAEFIMVLAN 240
Query: 240 VASTLDKMALEIRNLQRTEILEVSEPFG-EKQVGSSTMPHKRNPIRTEKVCGLARVLYSN 298
+A+TLDK+ALEIRNLQRTEI+EV E F EKQVGSSTMPHK NPI E++CG+ARV+ S
Sbjct: 241 IATTLDKIALEIRNLQRTEIMEVGEKFDPEKQVGSSTMPHKMNPITAERICGIARVIRSY 300
Query: 299 VIPALLNNPLWHERDLTNSSVERVILPESFVLLDEMLKVMKKVLKGLEFFPENIKRNLYL 358
V+ AL NNPLWHERDLTNSS ER+ILPE+ +L D +LK+ VL L F+PENIKRNL
Sbjct: 301 VVAALENNPLWHERDLTNSSSERIILPEACILTDYILKLTLDVLCNLVFYPENIKRNLEF 360
Query: 359 TKNLIMAEPLMLKLAEKGMGRQEAHELVRQLAMKAFKEGRDLLEVVRKNEEAMKYLTEND 418
T LIMAE LM +L +GMGRQ A+ VRQ A++A + GR L +VV + E M YLT D
Sbjct: 361 TGGLIMAERLMAELTRRGMGRQTAYAAVRQCAIEASRTGRSLRDVVLERSEIMDYLTVED 420
Query: 419 LEG-LKPENYIGKAREIVENVV 439
LE + PE YIG AR +VE V+
Sbjct: 421 LEEIMNPETYIGSARRMVERVL 442
>gi|11499824 adenylosuccinate lyase (purB) [Archaeoglobus fulgidus]
>gi|6093856|sp|O28041|PUR8_ARCFU ADENYLOSUCCINATE LYASE
(ADENYLOSUCCINASE) (ASL) >gi|7436840|pir||B69530
adenylosuccinate lyase (purB) homolog - Archaeoglobus
fulgidus >gi|2648282|gb|AAB89013.1| (AE000950)
adenylosuccinate lyase (purB) [Archaeoglobus fulgidus]
Length = 444
Score = 464 bits (1180), Expect = e-129
Identities = 245/446 (54%), Positives = 323/446 (71%), Gaps = 5/446 (1%)
Query: 1 MAVHPIDYRYGSEEMRRVWEEENKLQKLLDVEAALARAHAKLGNIPEESARVISERANTK 60
M VHPIDYRYG+ EM+R+W E++K+++++ VE AL RA AK G + EE A+ ++A +
Sbjct: 1 MIVHPIDYRYGTPEMKRIWSEDSKIKRMVRVEMALLRALAKKGYLSEEEAKEAKKKAYS- 59
Query: 61 WVKLERVKEIEAEIHHDIMAVVKALSEVCGEHGKYVHLGATSNDIIDTANALLIKESLAI 120
V ERVKEIEAEI HDIMA+VKA++E G ++VH GATSNDIIDTA AL +++SL I
Sbjct: 60 -VTPERVKEIEAEIKHDIMALVKAITEATG--CRWVHFGATSNDIIDTATALQLRDSLKI 116
Query: 121 VEKDLKELRSILKELAKKHIDTVCIGRTHGQHAVPTTYGMKFALWLDEIQRHIERLQQLK 180
+E +K L +L + A ++ D VC+GRTHGQ A+PTTYG +FALW E+ RH RLQQ+K
Sbjct: 117 LEVKIKRLAKVLADKALEYKDVVCLGRTHGQAALPTTYGFRFALWAAEVARHYIRLQQMK 176
Query: 181 DRVLVGKMRGAVGTAASFGDKAFEIEKLVMEDLGLKPARITNQIIQRDVYAELMFFLALV 240
DR+LVG+M GAVGT A+FG FEIE+ VM L LKPA I++QII RD Y E + FLA +
Sbjct: 177 DRLLVGQMSGAVGTQAAFGKDGFEIEEEVMRLLNLKPALISSQIIPRDSYCEYLEFLANL 236
Query: 241 ASTLDKMALEIRNLQRTEILEVSEPFGEKQVGSSTMPHKRNPIRTEKVCGLARVLYSNVI 300
A+TL+K+AL R LQR E+ E+ E F KQVGSSTMPHKRNPI E VCGLARV+ V
Sbjct: 237 AATLEKIALNFRLLQRAEVGELMEKFEAKQVGSSTMPHKRNPIDCENVCGLARVVRGFVE 296
Query: 301 PALLNNPLWHERDLTNSSVERVILPESFVLLDEMLKVMKKVLKGLEFFPENIKRNLYLTK 360
P + LW ERDLTNSS ER+ L ES VL D +L M KV+ + ENI+RNL + +
Sbjct: 297 PQHQSAILWEERDLTNSSAERITLVESTVLADHILTKMIKVVSSVSLNLENIRRNLEMQR 356
Query: 361 NLIMAEPLMLKLAEKGMGRQEAHELVRQLAMKAFKEGRDLLEVVRKNEEAMKYLTENDL- 419
L ++E +M+++ ++G+GRQEAHE++RQ AM+A++ LL+ + K+E MKY E++L
Sbjct: 357 GLNLSEAVMIEMTKRGVGRQEAHEILRQAAMRAYENNSSLLDELLKDERVMKYFKEDELR 416
Query: 420 EGLKPENYIGKAREIVENVVNYVEEM 445
E LKPENY+G ARE VE VV +V E+
Sbjct: 417 EILKPENYLGTARERVERVVRWVNEV 442
>sp|O66856|PUR8_AQUAE ADENYLOSUCCINATE LYASE (ADENYLOSUCCINASE) (ASL)
>gi|7436836|pir||D70353 adenylosuccinate lyase - Aquifex
aeolicus >gi|2983215|gb|AAC06813.1| (AE000697)
adenylosuccinate lyase [Aquifex aeolicus]
Length = 437
Score = 390 bits (990), Expect = e-107
Identities = 196/431 (45%), Positives = 295/431 (67%), Gaps = 4/431 (0%)
Query: 9 RYGSEEMRRVWEEENKLQKLLDVEAALARAHAKLGNIPEESARVISERANTKWVKLERVK 68
RY +EM VW E NK +K LDVE A+ RA AKLG IP ++ + I E+ +E++K
Sbjct: 4 RYTRKEMGDVWSEVNKFKKWLDVEIAVCRAWAKLGKIPRDALKKIEEKTYVDKKVVEKIK 63
Query: 69 EIEAEIHHDIMAVVKALSEVCGEHGKYVHLGATSNDIIDTANALLIKESLAIVEKDLKEL 128
E E HD++A V ++E GE G+Y+H+G TS+D++DTA ALLI+E++ I+ KD+ ++
Sbjct: 64 EKEKVFKHDVLAFVSVIAEQVGEEGRYIHMGLTSSDVVDTALALLIREAIDIILKDIDKV 123
Query: 129 RSILKELAKKHIDTVCIGRTHGQHAVPTTYGMKFALWLDEIQRHIERLQQLKDRVLVGKM 188
+K LA +H DT+ +GRTHG HA P T+G+K +W DE++R ERL ++ VL GK+
Sbjct: 124 MEEIKRLAFEHKDTLMMGRTHGVHAEPYTFGLKMCVWYDEMRRQKERLLFARENVLYGKI 183
Query: 189 RGAVGTAASFGDKAFEIEKLVMEDLGLKPARITNQIIQRDVYAELMFFLALVASTLDKMA 248
GAVGT ++ E+EKL +E+LGLK + QI+ RD +A+L+ L L+AS+L+K A
Sbjct: 184 SGAVGTYSNIPP---EVEKLALEELGLKIEPASTQIVHRDRHAQLLTTLGLIASSLEKFA 240
Query: 249 LEIRNLQRTEILEVSEPFGEKQVGSSTMPHKRNPIRTEKVCGLARVLYSNVIPALLNNPL 308
EIR+LQRTE+LEV EPF + Q GSS MPHK+NPI +E++CGLARV+ +N IPA+ + L
Sbjct: 241 TEIRHLQRTEVLEVLEPFTKGQRGSSAMPHKKNPIHSERICGLARVIRANSIPAMEDVVL 300
Query: 309 WHERDLTNSSVERVILPESFVLLDEMLKVMKKVLKGLEFFPENIKRNLYLTKNLIMAEPL 368
WHERD+++SSVERVILP+SF+ LD +L + ++LKGL E +++N+ L+K L + +
Sbjct: 301 WHERDISHSSVERVILPDSFIALDYILNLFYEILKGLVVNKERMRKNMELSKGLYASSKI 360
Query: 369 MLKLAEKGMGRQEAHELVRQLAMKAFKEGRDLLEVVRKNEEAMKYLTENDLE-GLKPENY 427
++ L +KG+ R A+++V++ AMKA++ + E + ++ E KYLTE ++E L P +
Sbjct: 361 LVLLTQKGLSRDYAYDIVQRCAMKAWESDKTFKETLLEDPEVTKYLTEEEIEKALDPWEF 420
Query: 428 IGKAREIVENV 438
+ + E V
Sbjct: 421 LKNRDYVYEKV 431
>gb|AAK40580.1| Adenylosuccinate lyase (adenylosuccinase)(ASL) (purB) [Sulfolobus
solfataricus]
Length = 474
Score = 381 bits (968), Expect = e-105
Identities = 198/443 (44%), Positives = 298/443 (66%), Gaps = 4/443 (0%)
Query: 2 AVHPIDYRYGSEEMRRVWEEENKLQKLLDVEAALARAHAKLGNIPEESARVISERANTKW 61
++ P+++RYGS EMR+ + E L++ + VE AL +A K G + EE + + + + T
Sbjct: 21 SICPLEWRYGSNEMRKFFSREEILKRRIQVEIALLKALTKYGLVKEEDVQKVEKASLT-- 78
Query: 62 VKLERVKEIEAEIHHDIMAVVKALSEVCGEHGKYVHLGATSNDIIDTANALLIKESLAIV 121
++ E V E+E++I HD+MA+V ++E G+ G+YVH GATS DI+DTA AL+ ++++ +V
Sbjct: 79 IRPEEVDELESKIGHDVMAMVVLMAERSGDSGRYVHFGATSYDIVDTAYALVFRDAIRLV 138
Query: 122 EKDLKELRSILKELAKKHIDTVCIGRTHGQHAVPTTYGMKFALWLDEIQRHIERLQQLKD 181
+ + E+ ++ LA K+ D +GRTHGQHA+P T G K A ++ E R +ERL +++
Sbjct: 139 KTKVVEILEMMVSLAIKYKDLAMVGRTHGQHALPITLGFKIANYIYEFSRSLERLNEVEK 198
Query: 182 RVLVGKMRGAVGTAASFGDKAFEIEKLVMEDLGLKPARITNQIIQRDVYAELMFFLALVA 241
R++ GKM GAVGT A++G+ EIE+ VM+ LGL+P I+ Q+ RD +AEL LA++A
Sbjct: 199 RIVKGKMAGAVGTMAAWGNIGLEIEENVMKFLGLRPHEISTQVAPRDAFAELTSDLAILA 258
Query: 242 STLDKMALEIRNLQRTEILEVSEPFGEKQVGSSTMPHKRNPIRTEKVCGLARVLYSNVIP 301
S D+ ALE+R L R EI E+SE E +VGSSTMP K NP+ +EK+ GLA+VL S V+
Sbjct: 259 SQCDRFALEVRELMRPEINEISEGV-EGRVGSSTMPQKENPVTSEKIGGLAKVLRSLVVA 317
Query: 302 ALLNNPLWHERDLTNSSVERVILPESFVLLDEMLKVMKKVLKGLEFFPENIKRNLYLTKN 361
+L N PLWHERDLTNSS ER+I+ F+++DE+L M +L+ L ENI++NL LTK
Sbjct: 318 SLENIPLWHERDLTNSSSERIIISHEFLVIDEILDSMISLLRNLRVNFENIEKNLNLTKG 377
Query: 362 LIMAEPLMLKLAEKGMGRQEAHELVRQLAMKAFKEGRDLLEVVRKNEEAMKYLTENDLEG 421
IMAE LM+ L KGM R EAH+ V +L K + G+ LLEV ++ + Y ++ +LE
Sbjct: 378 QIMAESLMINLTLKGMKRHEAHQYVNKLTSKVRQTGKTLLEVCLEDSLILSYFSKQELEN 437
Query: 422 -LKPENYIGKAREIVENVVNYVE 443
L P+NY+G +++E ++Y +
Sbjct: 438 VLNPKNYLGSYDKLIERAISYAK 460
>dbj|BAB04344.1| (AP001509) adenylosuccinate lyase [Bacillus halodurans]
Length = 433
Score = 357 bits (907), Expect = 1e-97
Identities = 187/419 (44%), Positives = 275/419 (65%), Gaps = 6/419 (1%)
Query: 9 RYGSEEMRRVWEEENKLQKLLDVEAALARAHAKLGNIPEESARVISERANTKWVKLERVK 68
RY EM +W EEN+ Q L+VE A A+LG IP+E + I E A+ +ER+
Sbjct: 4 RYTRPEMGAIWTEENRYQAWLEVEIVACEAWAELGEIPKEDVKKIREHAS---FDVERIL 60
Query: 69 EIEAEIHHDIMAVVKALSEVCGEHGKYVHLGATSNDIIDTANALLIKESLAIVEKDLKEL 128
EIE E HD++A +A+SE GE K+VH G TS D++DTA + L+K++ I+E DL
Sbjct: 61 EIEQETRHDVVAFTRAVSETLGEERKWVHYGLTSTDVVDTALSYLLKQANEIIEADLVRF 120
Query: 129 RSILKELAKKHIDTVCIGRTHGQHAVPTTYGMKFALWLDEIQRHIERLQQLKDRVLVGKM 188
ILKE A +H TV +GRTHG HA PTT+G+K ALW +E++R++ER + + V VGK+
Sbjct: 121 LDILKEKALEHKYTVMMGRTHGVHAEPTTFGLKLALWYEEMKRNLERFRLAAEGVRVGKL 180
Query: 189 RGAVGTAASFGDKAFEIEKLVMEDLGLKPARITNQIIQRDVYAELMFFLALVASTLDKMA 248
GAVGT A+ +E+ V E LGL+ A I+ Q +QRD +AE M LAL+A++++K A
Sbjct: 181 SGAVGTYANIDPF---VEQYVCEKLGLERAPISTQTLQRDRHAEYMATLALIATSIEKFA 237
Query: 249 LEIRNLQRTEILEVSEPFGEKQVGSSTMPHKRNPIRTEKVCGLARVLYSNVIPALLNNPL 308
+EIR LQ++E EV E F + Q GSS MPHKRNPI +E + G+ARV+ +++ A N PL
Sbjct: 238 VEIRGLQKSETREVEEYFAKGQKGSSAMPHKRNPIGSENMTGIARVVRGHMLAAYENVPL 297
Query: 309 WHERDLTNSSVERVILPESFVLLDEMLKVMKKVLKGLEFFPENIKRNLYLTKNLIMAEPL 368
WHERD+++SS ER+ILP++ + ++ ML ++K L FPEN+KRN+ T LI ++ +
Sbjct: 298 WHERDISHSSAERIILPDATIAINYMLNRFGNIVKNLTVFPENMKRNMTRTYGLIYSQRV 357
Query: 369 MLKLAEKGMGRQEAHELVRQLAMKAFKEGRDLLEVVRKNEEAMKYLTENDLEGLKPENY 427
+L L +KGM R+EA++LV+ AM+A+++G E+V + E L+ ++E N+
Sbjct: 358 LLSLIDKGMVREEAYDLVQPKAMEAWEKGVQFRELVEQEERITSVLSPEEIEACFDYNH 416
>sp|P12047|PUR8_BACSU ADENYLOSUCCINATE LYASE (ADENYLOSUCCINASE) (ASL) (GLUTAMYL-TRNA
SYNTHETASE REGULATORY FACTOR) >gi|68302|pir||WZBSDS
adenylosuccinate lyase (EC 4.3.2.2) - Bacillus subtilis
>gi|143366|gb|AAA22676.1| (J02732) adenylosuccinate
lyase (PUR-B) [Bacillus subtilis]
>gi|2632958|emb|CAB12464.1| (Z99107) adenylosuccinate
lyase [Bacillus subtilis]
Length = 431
Score = 345 bits (875), Expect = 7e-94
Identities = 182/419 (43%), Positives = 272/419 (64%), Gaps = 6/419 (1%)
Query: 9 RYGSEEMRRVWEEENKLQKLLDVEAALARAHAKLGNIPEESARVISERANTKWVKLERVK 68
RY EM +W +EN+ Q L+VE A A+LG IP+E +V+ E A+ + R+
Sbjct: 4 RYSRPEMSAIWTDENRFQAWLEVEILACEAWAELGVIPKEDVKVMRENAS---FDINRIL 60
Query: 69 EIEAEIHHDIMAVVKALSEVCGEHGKYVHLGATSNDIIDTANALLIKESLAIVEKDLKEL 128
EIE + HD++A +A+SE GE K+VH G TS D++DTA + L+K++ I+ KDL+
Sbjct: 61 EIEKDTRHDVVAFTRAVSESLGEERKWVHYGLTSTDVVDTALSYLLKQANDILLKDLERF 120
Query: 129 RSILKELAKKHIDTVCIGRTHGQHAVPTTYGMKFALWLDEIQRHIERLQQLKDRVLVGKM 188
I+KE AK+H TV +GRTHG HA PTT+G+K ALW +E++R++ER +Q K + VGK+
Sbjct: 121 VDIIKEKAKEHKYTVMMGRTHGVHAEPTTFGLKLALWHEEMKRNLERFKQAKAGIEVGKI 180
Query: 189 RGAVGTAASFGDKAFEIEKLVMEDLGLKPARITNQIIQRDVYAELMFFLALVASTLDKMA 248
GAVGT A+ +E+ V E LGLK A I+ Q +QRD +A+ M LAL+A++++K A
Sbjct: 181 SGAVGTYANIDPF---VEQYVCEKLGLKAAPISTQTLQRDRHADYMATLALIATSIEKFA 237
Query: 249 LEIRNLQRTEILEVSEPFGEKQVGSSTMPHKRNPIRTEKVCGLARVLYSNVIPALLNNPL 308
+EIR LQ++E EV E F + Q GSS MPHKRNPI +E + G+ARV+ ++ A N PL
Sbjct: 238 VEIRGLQKSETREVEEFFAKGQKGSSAMPHKRNPIGSENMTGMARVIRGYMMTAYENVPL 297
Query: 309 WHERDLTNSSVERVILPESFVLLDEMLKVMKKVLKGLEFFPENIKRNLYLTKNLIMAEPL 368
WHERD+++SS ER+ILP++ + L+ ML ++K L FPEN+KRN+ T LI ++ +
Sbjct: 298 WHERDISHSSAERIILPDATIALNYMLNRFSNIVKNLTVFPENMKRNMDRTLGLIYSQRV 357
Query: 369 MLKLAEKGMGRQEAHELVRQLAMKAFKEGRDLLEVVRKNEEAMKYLTENDLEGLKPENY 427
+L L + G+ R+EA++ V+ AM+A+++ E+V E+ L+ + NY
Sbjct: 358 LLALIDTGLTREEAYDTVQPKAMEAWEKQVPFRELVEAEEKITSRLSPEKIADCFDYNY 416
>emb|CAC11663.1| (AL445064) probable adenylosuccinate lyase [Thermoplasma
acidophilum]
Length = 455
Score = 342 bits (867), Expect = 6e-93
Identities = 188/446 (42%), Positives = 280/446 (62%), Gaps = 4/446 (0%)
Query: 1 MAVHPIDYRYGSEEMRRVWEEENKLQKLLDVEAALARAHAKLGNIPEESARVISERANTK 60
M V PI+YRYG ++++++++E +L +L VEAA+A+A ++LG IP+++ I ++
Sbjct: 1 MVVSPIEYRYGRRQVKKIFDDETRLNYMLKVEAAIAKAESELGIIPQDAYNEIQRAVDSG 60
Query: 61 WVKLERVKEIEAEIHHDIMAVVKALSEVCGEHGKYVHLGATSNDIIDTANALLIKESLAI 120
+ L+ V+++E EI HD+MAVV+ LS+ G KYVH G TSNDI DTA AL + + +I
Sbjct: 61 SITLDEVRQVEDEIKHDVMAVVRVLSKYSGSGSKYVHFGVTSNDINDTATALQLHDFSSI 120
Query: 121 VEKDLKELRSILKELAKKHIDTVCIGRTHGQHAVPTTYGMKFALWLDEIQRHIERLQQLK 180
+L L LA K+ D +GRTHGQHA P T G+KFA++L E+ RH++R ++
Sbjct: 121 YRSNLVSFMETLVGLASKYRDLPMMGRTHGQHASPITLGLKFAVYLAEMIRHLDRWDEMA 180
Query: 181 DRVLVGKMRGAVGTAASFGDKAFEIEKLVMEDLGLKPARITNQIIQRDVYAELMFFLALV 240
R GK+ G VGT A+ G+ A +++K VM+ LG+ P QI+ RD Y E + + +
Sbjct: 181 GRAFAGKVLGPVGTGAALGEMALDVQKRVMDILGIYPEDGATQIVNRDRYIEYLSVINGI 240
Query: 241 ASTLDKMALEIRNLQRTEILEVSEPFG-EKQVGSSTMPHKRNPIRTEKVCGLARVLYSNV 299
+ TL+K+A EIRNLQR EI E+SE F EKQVGSS+MP K NPI +E V L+R + S +
Sbjct: 241 SVTLEKIATEIRNLQRPEIDELSEYFDFEKQVGSSSMPSKVNPINSENVVSLSRFIRSLI 300
Query: 300 IPALLNNPLWHERDLTNSSVERVILPESFVLLDEMLKVMKKVLKGLEFFPENIKRNLYLT 359
I WHERDLTNS+ ER ++P + +L+D + VLK L +NI+RNL
Sbjct: 301 ISEYEAGVTWHERDLTNSASERFVIPYASILIDYATDRLNGVLKTLIVKEDNIRRNLE-N 359
Query: 360 KNLIMAEPLMLKLAEKGMGRQEAHELVRQLAMKAFKEGRDLLEVVRKNEEAMKYLTENDL 419
+ I +E ++ L E+GM RQ+AHE VR+ AM A +G + + +N +YL++ DL
Sbjct: 360 DDSIYSESIVTILTERGMARQDAHEFVRRSAMNARSKGMSFRQGLLEN-GIERYLSKADL 418
Query: 420 E-GLKPENYIGKAREIVENVVNYVEE 444
+ + P N+IG A I + +V +E
Sbjct: 419 DRAMDPANFIGLAPIICDTIVKKAKE 444
>sp|P56468|PUR8_HELPY ADENYLOSUCCINATE LYASE (ADENYLOSUCCINASE) (ASL)
>gi|7436834|pir||H64658 adenylosuccinate lyase -
Helicobacter pylori (strain 26695)
>gi|2314263|gb|AAD08156.1| (AE000617) adenylosuccinate
lyase (purB) [Helicobacter pylori 26695]
Length = 440
Score = 336 bits (852), Expect = 3e-91
Identities = 182/432 (42%), Positives = 269/432 (62%), Gaps = 16/432 (3%)
Query: 9 RYGSEEMRRVWEEENKLQKLLDVEAALARAHAKLGNIPEESARVISERANTKWVKLERVK 68
RY +EEM+ +W E+ K + L+VE A+ RA KLG I + I +A LER+K
Sbjct: 4 RYANEEMKALWNEQTKFETYLEVEKAVVRAWNKLGQIQDSDCEKICAKAA---FNLERIK 60
Query: 69 EIEAEIHHDIMAVVKALSEVCGEHGKYVHLGATSNDIIDTANALLIKESLAIVEKDLKEL 128
EIE HD++A ++E GE ++ H G TS+D IDTA ALL+ +SL +++K +K L
Sbjct: 61 EIEKTTKHDLIAFTTCVAESLGEESRFFHYGITSSDCIDTAMALLMTKSLKLIQKGVKNL 120
Query: 129 RSILKELAKKHIDTVCIGRTHGQHAVPTTYGMKFALWLDEIQRHIERLQQLKDRVLVGKM 188
LK A +H DT+ +GR+HG P T+G+ AL+ DEI+RH++ L + + VG +
Sbjct: 121 YETLKNRALEHKDTLMVGRSHGVFGEPITFGLVLALFADEIKRHLKALDLTMEFISVGAI 180
Query: 189 RGAVGTAASFGDKAFEIEKLVMEDLGLKPARITNQIIQRDVYAELMFFLALVASTLDKMA 248
GA+G +F E+E+L E LGLK A I+NQ+IQRD YA L LAL+AS+ +K+A
Sbjct: 181 SGAMG---NFAHAPLELEELACEFLGLKTANISNQVIQRDRYARLACDLALLASSCEKIA 237
Query: 249 LEIRNLQRTEILEVSEPFGEKQVGSSTMPHKRNPIRTEKVCGLARVLYSNVIPALLNNPL 308
+ IR+LQR+E+ EV E F Q GSS MPHKRNPI +E + GL RV+ S P L N L
Sbjct: 238 VNIRHLQRSEVYEVEEAFSTGQKGSSAMPHKRNPILSENITGLCRVIRSFTTPMLENVAL 297
Query: 309 WHERDLTNSSVERVILPESFVLLDEMLKVMKKVLKGLEFFPENIKRNLYLTKNLIMAEPL 368
WHERD+++SSVER LP+ F+ D ML + V+K L +P+N+ +NL L+ L+ ++ +
Sbjct: 298 WHERDMSHSSVERFALPDLFITSDFMLSRLNSVIKNLVVYPKNMLKNLALSGGLVFSQRV 357
Query: 369 MLKLAEKGMGRQEAHELVRQLAMK--------AFKEGRD--LLEVVRKNEEAMKYLTEND 418
+L+L +KG+ R+E++ +V++ AMK AFK + L + +E KYL+E++
Sbjct: 358 LLELPKKGLSREESYSIVQENAMKIWEVLQQGAFKNTDENLFLNALLNDERLKKYLSEDE 417
Query: 419 LEGLKPENYIGK 430
++ NY K
Sbjct: 418 IKACFDYNYYTK 429
>sp|P74384|PUR8_SYNY3 ADENYLOSUCCINATE LYASE (ADENYLOSUCCINASE) (ASL)
>gi|7436835|pir||S76222 hypothetical protein -
Synechocystis sp. (strain PCC 6803)
>gi|1653568|dbj|BAA18481.1| (D90914) adenylosuccinate
lyase [Synechocystis sp.]
Length = 431
Score = 330 bits (838), Expect = 2e-89
Identities = 177/428 (41%), Positives = 278/428 (64%), Gaps = 8/428 (1%)
Query: 9 RYGSEEMRRVWEEENKLQKLLDVEAALARAHAKLGNIPEESARVISERANTKWVKLERVK 68
RY EM ++W + KLQ LDVE A+ A A+LG IP+ + I +A +RV
Sbjct: 4 RYTLPEMGKIWTDTYKLQTWLDVEIAVCEAQAELGYIPQAAVDEIKAKAK---FDPQRVL 60
Query: 69 EIEAEIHHDIMAVVKALSEVCGEHGKYVHLGATSNDIIDTANALLIKESLAIVEKDLKEL 128
EIEAE+ HD++A + ++E G+ G+Y+HLG TS+D++DTA AL + SL ++ + L++L
Sbjct: 61 EIEAEVRHDVIAFLTNVNEYVGDAGRYIHLGLTSSDVLDTALALQLVASLDLILEQLEKL 120
Query: 129 RSILKELAKKHIDTVCIGRTHGQHAVPTTYGMKFALWLDEIQRHIERLQQLKDRVLVGKM 188
++ A++H TV +GR+HG HA P T+G K A WL E+ R+ +RL ++ + VGK+
Sbjct: 121 IQAIRYQAQQHRYTVMVGRSHGIHAEPITFGFKLAGWLAEVLRNRDRLVRVAQSIAVGKI 180
Query: 189 RGAVGTAASFGDKAFEIEKLVMEDLGLKPARITNQIIQRDVYAELMFFLALVASTLDKMA 248
GAVGT A+ K +E + + LGL+P + Q+I RD +AE + LAL+A++L++ A
Sbjct: 181 SGAVGTYANIDPK---VEAIACQKLGLEPDTASTQVISRDRHAEYVQQLALLAASLERFA 237
Query: 249 LEIRNLQRTEILEVSEPFGEKQVGSSTMPHKRNPIRTEKVCGLARVLYSNVIPALLNNPL 308
+EIRNLQRT++LEV E F + Q GSS MPHKRNPIR+E++ G+AR++ + + AL N L
Sbjct: 238 VEIRNLQRTDVLEVEEYFSKGQKGSSAMPHKRNPIRSERLTGMARLVRGHAVAALENVAL 297
Query: 309 WHERDLTNSSVERVILPESFVLLDEMLKVMKKVLKGLEFFPENIKRNLYLTKNLIMAEPL 368
WHERD+++SSVERV P+ +L MLK ++K L +PEN+KRN+ + +I ++ +
Sbjct: 298 WHERDISHSSVERVAFPDCCILTHFMLKETTDLVKNLLVYPENMKRNMNVYGGVIFSQKV 357
Query: 369 MLKLAEKGMGRQEAHELVRQLAMKAFK-EGRDLLEVVRKNEEAMKYLTENDLEG-LKPEN 426
+L L EKGM R++A+ +V+ A +A+ EG + E+VR + + L+ +++ P+
Sbjct: 358 LLALVEKGMNREDAYRVVQGSAHQAWNTEGGNFEELVRADAQVTALLSAEEIDQCFDPQQ 417
Query: 427 YIGKAREI 434
++ EI
Sbjct: 418 HLTNLAEI 425
>sp|Q9ZKA2|PUR8_HELPJ ADENYLOSUCCINATE LYASE (ADENYLOSUCCINASE) (ASL)
>gi|7436833|pir||B71858 adenylosuccinate lyase -
Helicobacter pylori (strain J99)
>gi|4155619|gb|AAD06609.1| (AE001531) ADENYLOSUCCINATE
LYASE [Helicobacter pylori J99]
Length = 440
Score = 329 bits (834), Expect = 5e-89
Identities = 179/432 (41%), Positives = 266/432 (61%), Gaps = 16/432 (3%)
Query: 9 RYGSEEMRRVWEEENKLQKLLDVEAALARAHAKLGNIPEESARVISERANTKWVKLERVK 68
RY +EEM+ +W E+ K + L+VE A+ RA KLG I + I +A LER+K
Sbjct: 4 RYANEEMKALWNEQTKFETYLEVEKAVVRAWNKLGQIQDSDCEKICLKAA---FNLERIK 60
Query: 69 EIEAEIHHDIMAVVKALSEVCGEHGKYVHLGATSNDIIDTANALLIKESLAIVEKDLKEL 128
EIE HD++A ++E GE ++ H G TS+D IDTA ALL+ +SL +++K +K L
Sbjct: 61 EIEKTTKHDLIAFTTCVAESLGEESRFFHYGITSSDCIDTAMALLMTKSLKLIQKGVKNL 120
Query: 129 RSILKELAKKHIDTVCIGRTHGQHAVPTTYGMKFALWLDEIQRHIERLQQLKDRVLVGKM 188
LK A +H DT+ +GR+HG P T+G+ AL+ DEI+RH++ L + + VG +
Sbjct: 121 YETLKNRALEHQDTLMVGRSHGVFGEPITFGLVLALFADEIKRHLKALDLTMEFISVGAI 180
Query: 189 RGAVGTAASFGDKAFEIEKLVMEDLGLKPARITNQIIQRDVYAELMFFLALVASTLDKMA 248
GA+G +F E+E+L LGLK A I+NQ+IQRD YA L LAL+AS+ +K+A
Sbjct: 181 SGAMG---NFAHAPLELEELACGFLGLKTANISNQVIQRDRYARLACDLALLASSCEKIA 237
Query: 249 LEIRNLQRTEILEVSEPFGEKQVGSSTMPHKRNPIRTEKVCGLARVLYSNVIPALLNNPL 308
+ IR+LQR+E+ EV E F Q GSS MPHKRNPI +E + GL RV+ S P L N L
Sbjct: 238 VNIRHLQRSEVYEVEEAFSAGQKGSSAMPHKRNPILSENITGLCRVIRSFTTPMLENVAL 297
Query: 309 WHERDLTNSSVERVILPESFVLLDEMLKVMKKVLKGLEFFPENIKRNLYLTKNLIMAEPL 368
WHERD+++SSVER LP+ F+ D ML + V++ L +P+N+ +NL L+ L+ ++ +
Sbjct: 298 WHERDMSHSSVERFALPDLFITSDFMLSRLNSVIENLVVYPKNMLKNLALSGGLVFSQRV 357
Query: 369 MLKLAEKGMGRQEAHELVRQLAMK--------AFKEGRD--LLEVVRKNEEAMKYLTEND 418
+L+L +KG+ R+E++ +V++ AMK AFK + L + +E KYL E++
Sbjct: 358 LLELPKKGLSREESYSIVQENAMKIWEVLQQGAFKNADENLFLNALLNDERLKKYLNESE 417
Query: 419 LEGLKPENYIGK 430
+ +Y K
Sbjct: 418 IRACFDYSYYTK 429
>pdb|1C3C|A Chain A, T. Maritima Adenylosuccinate Lyase >gi|7245817|pdb|1C3C|B
Chain B, T. Maritima Adenylosuccinate Lyase
Length = 429
Score = 324 bits (821), Expect = 2e-87
Identities = 166/419 (39%), Positives = 275/419 (65%), Gaps = 6/419 (1%)
Query: 9 RYGSEEMRRVWEEENKLQKLLDVEAALARAHAKLGNIPEESARVISERANTKWVKLERVK 68
RY M+ +W EE K ++ L+VE A+ RA+ +LG IP+ I A + +E K
Sbjct: 3 RYSLSPMKDLWTEEAKYRRWLEVELAVTRAYEELGMIPKGVTERIRNNAK---IDVELFK 59
Query: 69 EIEAEIHHDIMAVVKALSEVCGEHGKYVHLGATSNDIIDTANALLIKESLAIVEKDLKEL 128
+IE + +HD++A V+ + + GE ++ H G TS+D++DTAN+L + E+ I+ + LKE
Sbjct: 60 KIEEKTNHDVVAFVEGIGSMIGEDSRFFHYGLTSSDVLDTANSLALVEAGKILLESLKEF 119
Query: 129 RSILKELAKKHIDTVCIGRTHGQHAVPTTYGMKFALWLDEIQRHIERLQQLKDRVLVGKM 188
+L E+A ++ T IGRTHG HA PT++G+K W E++R+++RL++ + V GK+
Sbjct: 120 CDVLWEVANRYKHTPTIGRTHGVHAEPTSFGLKVLGWYSEMKRNVQRLERAIEEVSYGKI 179
Query: 189 RGAVGTAASFGDKAFEIEKLVMEDLGLKPARITNQIIQRDVYAELMFFLALVASTLDKMA 248
GAVG A+ E+E+ + LGLKP ++ Q++ RD +A + LA+VA+ ++++A
Sbjct: 180 SGAVGNYANVPP---EVEEKALSYLGLKPEPVSTQVVPRDRHAFYLSTLAIVAAGIERIA 236
Query: 249 LEIRNLQRTEILEVSEPFGEKQVGSSTMPHKRNPIRTEKVCGLARVLYSNVIPALLNNPL 308
+EIR+LQRTE+LEV EPF + Q GSS MPHK+NPI E++ GL+R++ + V P+L N L
Sbjct: 237 VEIRHLQRTEVLEVEEPFRKGQRGSSAMPHKKNPITCERLTGLSRMMRAYVDPSLENIAL 296
Query: 309 WHERDLTNSSVERVILPESFVLLDEMLKVMKKVLKGLEFFPENIKRNLYLTKNLIMAEPL 368
WHERD+++SSVER + P++ L M+ V++ ++ E +K+N+ LTK L+ ++ +
Sbjct: 297 WHERDISHSSVERYVFPDATQTLYYMIVTATNVVRNMKVNEERMKKNIDLTKGLVFSQRV 356
Query: 369 MLKLAEKGMGRQEAHELVRQLAMKAFKEGRDLLEVVRKNEEAMKYLTENDLEGLKPENY 427
+LKL EKG+ R+EA+++V++ A+K + + LE + ++EE K +T+ +LE L +Y
Sbjct: 357 LLKLIEKGLTRKEAYDIVQRNALKTWNSEKHFLEYLLEDEEVKKLVTKEELEELFDISY 415
>sp|Q9X0I0|PUR8_THEMA ADENYLOSUCCINATE LYASE (ADENYLOSUCCINASE) (ASL)
>gi|7436837|pir||A72294 adenylosuccinate lyase -
Thermotoga maritima (strain MSB8) >gi|7245290|pdb|1C3U|A
Chain A, T. Maritima Adenylosuccinate Lyase
>gi|7245291|pdb|1C3U|B Chain B, T. Maritima
Adenylosuccinate Lyase
>gi|4981640|gb|AAD36171.1|AE001769_1 (AE001769)
adenylosuccinate lyase [Thermotoga maritima]
Length = 431
Score = 324 bits (821), Expect = 2e-87
Identities = 166/419 (39%), Positives = 275/419 (65%), Gaps = 6/419 (1%)
Query: 9 RYGSEEMRRVWEEENKLQKLLDVEAALARAHAKLGNIPEESARVISERANTKWVKLERVK 68
RY M+ +W EE K ++ L+VE A+ RA+ +LG IP+ I A + +E K
Sbjct: 4 RYSLSPMKDLWTEEAKYRRWLEVELAVTRAYEELGMIPKGVTERIRNNAK---IDVELFK 60
Query: 69 EIEAEIHHDIMAVVKALSEVCGEHGKYVHLGATSNDIIDTANALLIKESLAIVEKDLKEL 128
+IE + +HD++A V+ + + GE ++ H G TS+D++DTAN+L + E+ I+ + LKE
Sbjct: 61 KIEEKTNHDVVAFVEGIGSMIGEDSRFFHYGLTSSDVLDTANSLALVEAGKILLESLKEF 120
Query: 129 RSILKELAKKHIDTVCIGRTHGQHAVPTTYGMKFALWLDEIQRHIERLQQLKDRVLVGKM 188
+L E+A ++ T IGRTHG HA PT++G+K W E++R+++RL++ + V GK+
Sbjct: 121 CDVLWEVANRYKHTPTIGRTHGVHAEPTSFGLKVLGWYSEMKRNVQRLERAIEEVSYGKI 180
Query: 189 RGAVGTAASFGDKAFEIEKLVMEDLGLKPARITNQIIQRDVYAELMFFLALVASTLDKMA 248
GAVG A+ E+E+ + LGLKP ++ Q++ RD +A + LA+VA+ ++++A
Sbjct: 181 SGAVGNYANVPP---EVEEKALSYLGLKPEPVSTQVVPRDRHAFYLSTLAIVAAGIERIA 237
Query: 249 LEIRNLQRTEILEVSEPFGEKQVGSSTMPHKRNPIRTEKVCGLARVLYSNVIPALLNNPL 308
+EIR+LQRTE+LEV EPF + Q GSS MPHK+NPI E++ GL+R++ + V P+L N L
Sbjct: 238 VEIRHLQRTEVLEVEEPFRKGQRGSSAMPHKKNPITCERLTGLSRMMRAYVDPSLENIAL 297
Query: 309 WHERDLTNSSVERVILPESFVLLDEMLKVMKKVLKGLEFFPENIKRNLYLTKNLIMAEPL 368
WHERD+++SSVER + P++ L M+ V++ ++ E +K+N+ LTK L+ ++ +
Sbjct: 298 WHERDISHSSVERYVFPDATQTLYYMIVTATNVVRNMKVNEERMKKNIDLTKGLVFSQRV 357
Query: 369 MLKLAEKGMGRQEAHELVRQLAMKAFKEGRDLLEVVRKNEEAMKYLTENDLEGLKPENY 427
+LKL EKG+ R+EA+++V++ A+K + + LE + ++EE K +T+ +LE L +Y
Sbjct: 358 LLKLIEKGLTRKEAYDIVQRNALKTWNSEKHFLEYLLEDEEVKKLVTKEELEELFDISY 416
>pir||B81418 adenylosuccinate lyase (EC 4.3.2.2) Cj0023 [imported] -
Campylobacter jejuni (strain NCTC 11168)
>gi|6967528|emb|CAB72516.1| (AL139074) adenylosuccinate
lyase [Campylobacter jejuni]
Length = 442
Score = 307 bits (777), Expect = 2e-82
Identities = 171/434 (39%), Positives = 262/434 (59%), Gaps = 18/434 (4%)
Query: 9 RYGSEEMRRVWEEENKLQKLLDVEAALARAHAKLGNIPEESARVISERANTKWVKLERVK 68
RY E M + W+ + K L VE A +A KLG I + I + A + R+
Sbjct: 4 RYSREIMAKKWDMQAKYDAWLKVELAAVKAWNKLGLIDDTDCEKILKNAK---FDIARID 60
Query: 69 EIEAEIHHDIMAVVKALSEVCGEHGKYVHLGATSNDIIDTANALLIKESLAIVEKDLKEL 128
EIE HD++A + ++SE GE ++VH TS+D IDTA AL IKESL ++ +D+ L
Sbjct: 61 EIEKTTKHDVIAFLTSVSESLGEESRFVHYAMTSSDCIDTAVALQIKESLELILEDVSLL 120
Query: 129 RSILKELAKKHIDTVCIGRTHGQHAVPTTYGMKFALWLDEIQRHIERLQQLKDRVLVGKM 188
+K+ A +H +T+ +GR+HG H P T+G+ A+W DEI E L+ K+ + GK+
Sbjct: 121 LEAIKKRALEHKNTLMVGRSHGIHGEPITFGLVLAIWYDEISHAKELLEHAKEVISYGKI 180
Query: 189 RGAVGTAASFGDKAFEIEKLVMEDLGLKPARITNQIIQRDVYAELMFFLALVASTLDKMA 248
GA+G +F E E+ V ++LGLK A ++NQ+IQRD YA+++ +A++AS+ +++A
Sbjct: 181 SGAMG---NFAHAPLEFEEEVCKNLGLKAAPVSNQVIQRDRYAQVISAIAILASSCEQIA 237
Query: 249 LEIRNLQRTEILEVSEPFGEKQVGSSTMPHKRNPIRTEKVCGLARVLYSNVIPALLNNPL 308
+ IR+ QRTE+ E E F Q GSS MPHKRNP+ +E + GL RVL S V PAL N L
Sbjct: 238 VAIRHFQRTEVYEAEEYFSVGQKGSSAMPHKRNPVLSENITGLCRVLRSFVTPALENVAL 297
Query: 309 WHERDLTNSSVERVILPESFVLLDEMLKVMKKVLKGLEFFPENIKRNLYLTKNLIMAEPL 368
WHERD+++SSVER ILP++F+ D ML + ++ L +PEN+ +NL LT L+ + +
Sbjct: 298 WHERDISHSSVERFILPDAFITADFMLMRLTNLIDKLLVYPENMMKNLNLTGGLVFSGRV 357
Query: 369 MLKLAEKGMGRQEAHELVRQLAMKAFKEGRD------------LLEVVRKNEEAMKYLTE 416
+L+L KG+ R+EA+++V++ AMK + + ++ L + +E+ K L+E
Sbjct: 358 LLELPFKGISREEAYKIVQRNAMKVWADLQNGKAAINEKNESLFLLALLSDEDLRKSLSE 417
Query: 417 NDLEGLKPENYIGK 430
D+ NY K
Sbjct: 418 EDVRKCFDYNYYTK 431
>sp|Q9RSE6|PUR8_DEIRA ADENYLOSUCCINATE LYASE (ADENYLOSUCCINASE) (ASL)
>gi|7471086|pir||A75305 adenylosuccinate lyase -
Deinococcus radiodurans (strain R1)
>gi|6459979|gb|AAF11727.1|AE002051_3 (AE002051)
adenylosuccinate lyase [Deinococcus radiodurans]
Length = 435
Score = 295 bits (748), Expect = 5e-79
Identities = 160/405 (39%), Positives = 252/405 (61%), Gaps = 7/405 (1%)
Query: 9 RYGSEEMRRVWEEENKLQKLLDVEAALARAHAKLGNIPEESARVISERANTKWVK---LE 65
RY + EM+ +W E NK + L VE + +A A+ G +P E+ + +++ + +
Sbjct: 4 RYLTPEMKVLWSEANKYRAWLKVELSALQAQARHGEVPAEAHAALVQKSEADPLDDAFAQ 63
Query: 66 RVKEIEAEIHHDIMAVVKALSEVCGEHGKYVHLGATSNDIIDTANALLIKESLAIVEKDL 125
+V EIEA HDI+A +AL+E GE +++H G TS D++DTA LL+ E++ ++ D+
Sbjct: 64 QVAEIEAVTRHDIVAFTRALTERYGEEARFIHHGLTSTDVVDTAQNLLLDEAMGLIITDV 123
Query: 126 KELRSILKELAKKHIDTVCIGRTHGQHAVPTTYGMKFALWLDEIQRHIERLQQLKDRVLV 185
+ LR + + A H T +GRTHG HA P T+G+KF W+ + R +ERLQ + RV V
Sbjct: 124 QTLREVCRMQAAAHKHTPVVGRTHGIHAEPMTFGLKFLNWMATLDRDLERLQAARGRVQV 183
Query: 186 GKMRGAVGTAASFGDKAFEIEKLVMEDLGLKPARITNQIIQRDVYAELMFFLALVASTLD 245
+ G+VGT A K IE+ V E G A +TNQ + RD +AE++ LA++ +TL+
Sbjct: 184 VMLSGSVGTYAHVSPK---IEEEVAESWGWHAAPVTNQTLARDRHAEVLAALAILGTTLE 240
Query: 246 KMALEIRNLQRTEILEVSEPFGEKQVGSSTMPHKRNPIRTEKVCGLARVLYSNVIPALLN 305
K+A+EIR+LQR+E+ E EPFG+ Q GSS+MPHK+NPI TE V G AR+L + L N
Sbjct: 241 KIAVEIRHLQRSEVREAMEPFGKGQTGSSSMPHKKNPILTENVTGFARLLRGFLATGLEN 300
Query: 306 NPLWHERDLTNSSVERVILPESFVLLDEMLKVMKKVLKGLEFFPENIKRNLYLTKNLIMA 365
LWHERD+++SS ERVILP++ + + VL+ L FPE + +NL L+ +
Sbjct: 301 VALWHERDISHSSAERVILPDATASASYATRRLTGVLRDLVVFPERMLKNLDDLGGLVFS 360
Query: 366 EPLMLKLA-EKGMGRQEAHELVRQLAMKAFKEGRDLLEVVRKNEE 409
+ ++ L +KGM R+ A+ +V++ A+K+++ G L ++++ + E
Sbjct: 361 QRVLHALIDDKGMMREAAYGIVQRNALKSWETGEGLRDLLKADPE 405
>pir||D81284 probable fumarate lyase Cj1394 [imported] - Campylobacter jejuni
(strain NCTC 11168) >gi|6968825|emb|CAB73819.1|
(AL139078) putative fumarate lyase [Campylobacter
jejuni]
Length = 455
Score = 282 bits (714), Expect = 5e-75
Identities = 163/429 (37%), Positives = 259/429 (59%), Gaps = 4/429 (0%)
Query: 10 YGSEEMRRVWEEENKLQKLLDVEAALARAHAKLGNIPEESARVISERANTKWVKLERVKE 69
+ ++EMR ++ E+N++QK LDVEAALA+A AKL IP+++A I+++A+ K++ ++ +
Sbjct: 16 WSTQEMRAIFCEQNRIQKWLDVEAALAKAQAKLKIIPKKAADEIAKKAHYKFMDMDFIFA 75
Query: 70 IEAEIHHDIMAVVKALSEVCGEH-GKYVHLGATSNDIIDTANALLIKESLAIVEKDLKEL 128
+ H ++ V+ L + C + G+YVH T+ DIIDT L KE++ +V+ +LK +
Sbjct: 76 EFKKTKHPLVPTVRGLEKACDNNLGEYVHFRVTTQDIIDTGLVLQFKEAMTLVKSELKAI 135
Query: 129 RSILKELAKKHIDTVCIGRTHGQHAVPTTYGMKFALWLDEIQRHIERLQQLKDRVLVGKM 188
L +LAK H +T +GRT A+P T+G K A+WL E+ RH ER+ +L+ R+ VG +
Sbjct: 136 AKALAKLAKTHKNTAMMGRTLALQALPITFGHKVAIWLSELDRHFERILELEKRLYVGSI 195
Query: 189 RGAVGTAASFGDKAFEIEKLVMEDLGLKPARITNQIIQRDVYAELMFFLALVASTLDKMA 248
GAVGT AS D+ E+EKL +E+LGL+ I+ Q RD + EL F L + +T +K+A
Sbjct: 196 VGAVGTKASLSDECNEVEKLTLENLGLEVPNISWQ-STRDRFIELGFVLGNINATFNKIA 254
Query: 249 LEIRNLQRTEILEVSEPFGEKQVGSSTMPHKRNPIRTEKVCGLARVLYSNVIPALLNNPL 308
++ L EI EV+EPFG+ QVGSSTMPHKRNP +E ++ +N+
Sbjct: 255 HQLLILSHNEIDEVAEPFGKGQVGSSTMPHKRNPAVSENAVTVSNAFKANLAILSDIERH 314
Query: 309 WHERDLTNSSVERVILPESFVLLDEMLKVMKKVLKGLEFFPENIKRNLYLTKNLIMAEPL 368
HERD +E +LPE F++L +L MK L LE + + +NL K ++AE +
Sbjct: 315 EHERDGQVWKMEWKLLPEMFLMLSVVLANMKFALSDLEVKKDKMLKNLDTLKGFVLAERV 374
Query: 369 MLKLAEKGMGRQEAHELVRQLAMKAFKEGRDLLEVVRKNEEAMKYLTENDLEG-LKPENY 427
M L++ G+Q AHE+V + AM ++ + EV+ + + L E D++ L +Y
Sbjct: 375 MFALSDH-YGKQHAHEIVYENAMLGIEQQKTFKEVLLADTRVSQVLKEKDIDALLDATSY 433
Query: 428 IGKAREIVE 436
+G A ++V+
Sbjct: 434 VGYAPKLVD 442
>pir||G83205 probable lyase PA3517 [imported] - Pseudomonas aeruginosa (strain
PAO1) >gi|9949665|gb|AAG06905.1|AE004772_3 (AE004772)
probable lyase [Pseudomonas aeruginosa]
Length = 477
Score = 264 bits (668), Expect = 1e-69
Identities = 167/434 (38%), Positives = 244/434 (55%), Gaps = 5/434 (1%)
Query: 10 YGSEEMRRVWEEENKLQKLLDVEAALARAHAKLGNIPEESARVISERANTKWVKLERVKE 69
Y S ++ + N++++ LDVE ALA A++G IP E+AR I A + L ++
Sbjct: 15 YSSPAFAAIFSDTNQVRRWLDVERALAATQAEMGIIPHEAAREIDRAAQVERFDLTQLGR 74
Query: 70 IEAEIHHDIMAVVKALSEVC-GEHGKYVHLGATSNDIIDTANALLIKESLAIVEKDLKEL 128
E H ++ ++AL+ C G G+YVH G T+ DI+DT L +KE+ L +
Sbjct: 75 ESLETGHLLVPTIRALARSCEGSWGEYVHYGVTTQDILDTGLMLQVKEAWGHALGLLHSI 134
Query: 129 RSILKELAKKHIDTVCIGRTHGQHAVPTTYGMKFALWLDEIQRHIERLQQLKDRVLVGKM 188
R L LA +H T + RTHGQ A+PTT+G K A+W+DEI RH+ R + ++RVLVG +
Sbjct: 135 RGHLLALALRHQHTPMVARTHGQQALPTTFGYKVAVWVDEIDRHLARFDEARERVLVGNL 194
Query: 189 RGAVGTAASFGDKAFEIEKLVMEDLGLKPARITNQIIQRDVYAELMFFLALVASTLDKMA 248
GAVGT ASFG + FE+++ + LGL A T+ RD E+ L V+ TL ++A
Sbjct: 195 TGAVGTLASFGAQGFELQRRTLARLGL-GAPSTSWHSARDRVLEVAGLLVQVSVTLGRVA 253
Query: 249 LEIRNLQRTEILEVSEPFGEKQVGSSTMPHKRNPIRTEKVCGLARVLYSNVIPALLNNPL 308
EI +LQR+EI EV E QVGSSTMPHKRNP + V L+R++ + ++
Sbjct: 254 NEIYHLQRSEIDEVREGSRPGQVGSSTMPHKRNPSSVDLVSALSRLVRAQMVALTDAAFQ 313
Query: 309 WHERDLTNSSVERVILPESFVLLDEMLKVMKKVL-KGLEFFPENIKRNLYLTKNLIMAEP 367
HERD T +E LPE FV +L M+ VL +GLE E ++ NL L LI++E
Sbjct: 314 LHERDGTAWRIEWAALPELFVYAGALLTRMEAVLAEGLEVREERMRANLDLLGGLILSER 373
Query: 368 LMLKLAEKGMGRQEAHELVRQLAMKAFKEGRDLLEVVRKNEEAMKYLTENDLEG-LKPEN 426
+ML LA + G+Q AHEL+ ++ + ++G E + + LE L P
Sbjct: 374 VMLALAGQ-FGKQTAHELLHEITQASQRQGVPFREALLGQPRLRGCFSAEALEELLDPVG 432
Query: 427 YIGKAREIVENVVN 440
Y+G A E+V+ V +
Sbjct: 433 YVGLAAEMVDLVAD 446
>pir||T39170 probable cis-muconate cycloisomerase [imported] - fission yeast
(Schizosaccharomyces pombe) >gi|2879855|emb|CAA16998.1|
(AL021815) putative cis-muconate cycloisomerase
[Schizosaccharomyces pombe]
Length = 447
Score = 254 bits (641), Expect = 2e-66
Identities = 152/432 (35%), Positives = 240/432 (55%), Gaps = 4/432 (0%)
Query: 10 YGSEEMRRVWEEENKLQKLLDVEAALARAHAKLGNIPEESARVISERANTKWVKLERVKE 69
+G E+R++W +EN+ Q+ L+ EAALARA A LG IP+ + I + + +++E
Sbjct: 15 FGDAEIRKIWSDENRTQEYLNWEAALARAEASLGIIPKYAGEEIQRVCKVENIDFSKLEE 74
Query: 70 IEAEIHHDIMAVVKALSEVC-GEHGKYVHLGATSNDIIDTANALLIKESLAIVEKDLKEL 128
I + ++ VV L+ +C G+ GKY H GAT+ D+ D+A + +S I++ L++
Sbjct: 75 ETINIGYPVLGVVHQLANLCSGDSGKYCHWGATTQDVTDSATVRQMIDSFKIIKGYLEKA 134
Query: 129 RSILKELAKKHIDTVCIGRTHGQHAVPTTYGMKFALWLDEIQRHIERLQQLKDRVLVGKM 188
+ L KH +T GR++ Q AVP T+G K A ++ ++RH +RL +L RV V +
Sbjct: 135 IELATVLVIKHRETTMAGRSNLQQAVPITFGFKMARFVATLRRHHQRLCELLPRVSVLEF 194
Query: 189 RGAVGTAASFGDKAFEIEKLVMEDLGLKPARITNQIIQRDVYAELMFFLALVASTLDKMA 248
GA GT AS +K +++ + E+LGL I +RD AE FL ++ TL K A
Sbjct: 195 GGACGTLASLENKGLMVQQKLAEELGLLQPEIAWH-TERDRIAEAGCFLGMLTGTLAKFA 253
Query: 249 LEIRNLQRTEILEVSEPFGEKQVGSSTMPHKRNPIRTEKVCGLARVLYSNVIPALLNNPL 308
+I+ L +TE+ EV EPF + SSTMP KRNPI + + V L
Sbjct: 254 TDIKLLMQTEVAEVFEPFKANRGSSSTMPQKRNPISCVYITASTSFVRQGVAALLDAMVE 313
Query: 309 WHERDLTNSSVERVILPESFVLLDEMLKVMKKVLKGLEFFPENIKRNLYLTKNLIMAEPL 368
HER +E ++LP+ FV LK +L+GLE P + NL +T LI++E +
Sbjct: 314 DHERATGAWEIEWIVLPDVFVHTVGTLKQTVFLLEGLEVHPSRMNENLSITNGLIVSEAV 373
Query: 369 MLKLAEKGMGRQEAHELVRQLAMKAFKEGRDLLEVVRKNEEAMKYLTENDLEG-LKPENY 427
M+ LA K +GR EAH+LV +L + +E + L+E++ + YL++ ++ L PENY
Sbjct: 374 MMALAPK-LGRDEAHDLVYRLCHLSIQENKPLVELLLAERQVTNYLSKEEVTSLLNPENY 432
Query: 428 IGKAREIVENVV 439
+G E++E +
Sbjct: 433 LGSTFEMIERAL 444
>pir||B83616 3-carboxy-cis,cis-muconate cycloisomerase PA0230 [imported] -
Pseudomonas aeruginosa (strain PAO1)
>gi|9946068|gb|AAG03619.1|AE004461_2 (AE004461)
3-carboxy-cis,cis-muconate cycloisomerase [Pseudomonas
aeruginosa]
Length = 459
Score = 238 bits (601), Expect = 9e-62
Identities = 158/439 (35%), Positives = 237/439 (52%), Gaps = 9/439 (2%)
Query: 7 DYRYGSEEMRRVWEEENKLQKLLDVEAALARAHAKLGNIPEESARVISERANTKWVKLER 66
D + + MR V+ + +LQ +LD EAALARA A+ G +P + I +
Sbjct: 11 DAYFMAAPMRAVFSDRGRLQGMLDFEAALARAEARTGVVPATAVAPIEAACRAELYDPLA 70
Query: 67 VKEIEAEIHHDIMAVVKALSEVCG----EHGKYVHLGATSNDIIDTANALLIKESLAIVE 122
+ E A + + +VKAL E +YVHLGATS D +D+ L ++ +LA++E
Sbjct: 71 LAEAVATAGNSAIPLVKALGRQVAAGDAEAERYVHLGATSQDAMDSGLVLQLRRALALLE 130
Query: 123 KDLKELRSILKELAKKHIDTVCIGRTHGQHAVPTTYGMKFALWLDEIQRHIERLQQLKDR 182
+DL+ L +L + A++H DT GRT QHA P T GMK A L + RH +RL++L+ R
Sbjct: 131 QDLQRLAEVLADQAERHADTPLAGRTWLQHATPVTLGMKLAGLLGALTRHRQRLRELRPR 190
Query: 183 VLVGKMRGAVGTAASFGDKAFEIEKLVMEDLGLK-PARITNQIIQRDVYAELMFFLALVA 241
+LV + GA GT A+ G++A + + E+LGL P + + QRD E L LVA
Sbjct: 191 LLVLQFGGASGTLAALGEQALPVAAALAEELGLALPEQPWH--TQRDRLVEFASVLGLVA 248
Query: 242 STLDKMALEIRNLQRTEILEVSEPFGEKQVGSSTMPHKRNPIRTEKVCGLARVLYSNVIP 301
+L K ++ L +TE EV EP G + GSSTMPHKRNP+ + + A V
Sbjct: 249 GSLGKFGRDVSLLMQTEAGEVFEPAGAGRGGSSTMPHKRNPVSSAVLIAAATRAPGLVST 308
Query: 302 ALLNNPLWHERDLTNSSVERVILPESFVLLDEMLKVMKKVLKGLEFFPENIKRNLYLTKN 361
P HER L E LPE L+ L+ +L+GLE + ++RNL LT
Sbjct: 309 LFAAMPQEHERSLGLWHAEWETLPELCCLVAGALQQAIGLLEGLEVDAQRMRRNLGLTHG 368
Query: 362 LIMAEPLMLKLAEKGMGRQEAHELVRQLAMKAFKEGRDLLEVVRKNEEAMKYLTENDLEG 421
L++AE + + LA + +GR+ AH LV Q +A ++ R+L V+ + L+ ++L+
Sbjct: 369 LVLAEAVSIALARR-IGREAAHHLVEQCCRRAVEQRRELRAVLGEEARVSAELSGDELDR 427
Query: 422 -LKPENYIGKAREIVENVV 439
L P +Y+G+AR VE +
Sbjct: 428 LLDPAHYLGQARAWVERAL 446
>gb|AAD39559.1| (AF031417) PcaB-like protein [Pseudomonas putida]
Length = 450
Score = 235 bits (592), Expect = 1e-60
Identities = 158/445 (35%), Positives = 234/445 (52%), Gaps = 19/445 (4%)
Query: 7 DYRYGSEEMRRVWEEENKLQKLLDVEAALARAHAKLGNIPEESARVISERANTKWVKLER 66
D + + MR ++ + +LQ +LD EAALARA A G +P + I + +
Sbjct: 7 DAYFTAPAMREIFSDRGRLQGMLDFEAALARAEASAGLVPHSAVAAIEAACQAERYDVGA 66
Query: 67 VKEIEAEIHHDIMAVVKALSEVCG----EHGKYVHLGATSNDIIDTANALLIKESLAIVE 122
+ A + + +VKAL +V E +YVHLGATS D +DT L ++++L ++E
Sbjct: 67 LANAIATAGNSAIPLVKALGKVIATGVPEAERYVHLGATSQDAMDTGLVLQLRDALDLIE 126
Query: 123 KDLKELRSILKELAKKHIDTVCIGRTHGQHAVPTTYGMKFALWLDEIQRHIERLQQLKDR 182
DL +L L + A KH DT +GRT QHA P T GMK A L + RH +RLQ+L+ R
Sbjct: 127 ADLGKLADTLSQQALKHADTPLVGRTWLQHATPVTLGMKLAGVLGALTRHRQRLQELRPR 186
Query: 183 VLVGKMRGAVGTAASFGDKAFEIEKLVMEDLGLK-PARITNQIIQRDVYAELMFFLALVA 241
+LV + GA G+ A+ G KA + + + E L L P + + QRD E L LVA
Sbjct: 187 LLVLQFGGASGSLAALGSKAMPVAEALAEQLKLSLPEQPWH--TQRDRLVEFASVLGLVA 244
Query: 242 STLDKMALEIRNLQRTEILEVSEPFGEKQVGSSTMPHKRNPIRTEKVCGLARVLYSNVIP 301
+L K +I L +TE EV EP + GSSTMPHKRNP+ + G A +P
Sbjct: 245 GSLGKFGRDISLLMQTEAGEVFEPSAPGKGGSSTMPHKRNPVGAAVLIGAA-----TRVP 299
Query: 302 ALLNN-----PLWHERDLTNSSVERVILPESFVLLDEMLKVMKKVLKGLEFFPENIKRNL 356
LL+ P HER L E LP+ L+ L+ + + +G+E ++RNL
Sbjct: 300 GLLSTLFAAMPQEHERSLGLWHAEWETLPDICCLVSGALRQAQVIAEGMEVDAARMRRNL 359
Query: 357 YLTKNLIMAEPLMLKLAEKGMGRQEAHELVRQLAMKAFKEGRDLLEVVRKNEEAMKYLTE 416
LT+ L++AE + + LA++ +GR AH L+ Q +A E R L V+ + L+
Sbjct: 360 DLTQGLVLAEAVSIVLAQR-LGRDRAHHLLEQCCQRAVAEQRHLRAVLGDEPQVSAELSG 418
Query: 417 NDLEG-LKPENYIGKAREIVENVVN 440
+L+ L P +Y+G+AR V V+
Sbjct: 419 EELDRLLDPAHYLGQARVWVARAVS 443
>pir||F83205 probable lyase PA3516 [imported] - Pseudomonas aeruginosa (strain
PAO1) >gi|9949664|gb|AAG06904.1|AE004772_2 (AE004772)
probable lyase [Pseudomonas aeruginosa]
Length = 483
Score = 217 bits (548), Expect = 2e-55
Identities = 144/435 (33%), Positives = 233/435 (53%), Gaps = 4/435 (0%)
Query: 10 YGSEEMRRVWEEENKLQKLLDVEAALARAHAKLGNIPEESARVISERANTKWVKLERVKE 69
Y RR++ +LQ+ LDVEAALA A A +G IP E+A I++ A V L+++ +
Sbjct: 47 YAGPVSRRIFCSHCRLQRWLDVEAALALAQADVGVIPPEAALEIAKAARLSAVDLQQIAD 106
Query: 70 IEAEIHHDIMAVVKALSEVCGEHGK-YVHLGATSNDIIDTANALLIKESLAIVEKDLKEL 128
A H +M ++ AL C + YVH GAT+ DI DTA +L +++ L E+ L L
Sbjct: 107 GVASTGHSLMPLLGALQRNCSPSAREYVHFGATTQDIQDTAQSLEMRDVLDETERALDIL 166
Query: 129 RSILKELAKKHIDTVCIGRTHGQHAVPTTYGMKFALWLDEIQRHIERLQQLKDRVLVGKM 188
L LA + + + RTH A+PTT+G+K A W+DE+ RH ERL + + R+LV ++
Sbjct: 167 LDRLSVLASGTRNALMVARTHSIPALPTTFGLKVAGWIDELLRHRERLGEARKRILVVQL 226
Query: 189 RGAVGTAASFGDKAFEIEKLVMEDLGLKPARITNQIIQRDVYAELMFFLALVASTLDKMA 248
G VGT A+FGD+A + + L L + + RD E + LA+V ++L ++A
Sbjct: 227 FGGVGTMAAFGDEAMLLLESFARRLSL-DVPLAGWHVSRDRVTEFVSTLAMVTASLARIA 285
Query: 249 LEIRNLQRTEILEVSEPFGEKQVGSSTMPHKRNPIRTEKVCGLARVLYSNVIPALLNNPL 308
EIR L R EI E+ + ++Q+GSSTMPHKRNP E+V LAR+ + V+ AL L
Sbjct: 286 DEIRTLNRWEIGELEVGWTQQQIGSSTMPHKRNPEGCEQVVVLARLAKAQVLLALDAMIL 345
Query: 309 WHERDLTNSSVERVILPESFVLLDEMLKVMKKVLKGLEFFPENIKRNLYLTKNLIMAEPL 368
HERD + +E + + L ++ + GL E + R + I E
Sbjct: 346 EHERDYRGTRLEWCAVADVSHYALMALSLLTDTIDGLTVHDETMARTANAYSDAICTEAF 405
Query: 369 MLKLAEKGMGRQEAHELVRQLAMKAFKEGRDLLEVVRKNEEAMKYLTENDLEGL-KPENY 427
+ ++A K +G+ A+E++ ++ ++ + + + + + + L L +P +
Sbjct: 406 VFEMA-KQLGKSSAYEIIFEITQACQRKRIPMRQALESDPRVGAVMPKETLARLFEPRTH 464
Query: 428 IGKAREIVENVVNYV 442
+G A IV+ V++ V
Sbjct: 465 LGMAGTIVDKVLDKV 479
>gi|7705660 surfactant protein B [Homo sapiens] >gi|1220355|gb|AAB00076.1|
(L11573) 33.1 kDa protein [Homo sapiens]
Length = 296
Score = 212 bits (534), Expect = 7e-54
Identities = 112/276 (40%), Positives = 174/276 (62%), Gaps = 3/276 (1%)
Query: 145 IGRTHGQHAVPTTYGMKFALWLDEIQRHIERLQQLKDRVLVGKMRGAVGTAASFGDKAFE 204
+GRTHG HA PTT+G+K A + R IER ++ V GK+ GAVGT F +
Sbjct: 2 MGRTHGVHAEPTTFGLKMARFHASATRAIERFDRVAAEVETGKLSGAVGT---FANVPPY 58
Query: 205 IEKLVMEDLGLKPARITNQIIQRDVYAELMFFLALVASTLDKMALEIRNLQRTEILEVSE 264
+E + M++LGL P I +Q++ RD++A+ + +AL+ + ++++A EIR+LQR+EI EV E
Sbjct: 59 VEAVAMKELGLTPQPIGSQVLPRDLHADYVQTIALIGTQMEELATEIRSLQRSEIHEVEE 118
Query: 265 PFGEKQVGSSTMPHKRNPIRTEKVCGLARVLYSNVIPALLNNPLWHERDLTNSSVERVIL 324
F + Q GSS MPHKRNPI E + GLARVL + AL + LWHERD+++SS ER+IL
Sbjct: 119 GFAKGQKGSSAMPHKRNPIGNENITGLARVLRGYAVTALEDVTLWHERDISHSSAERIIL 178
Query: 325 PESFVLLDEMLKVMKKVLKGLEFFPENIKRNLYLTKNLIMAEPLMLKLAEKGMGRQEAHE 384
P++ LD ML +LK L FPE ++ N+ T LI ++ L+L L + G+ R++A++
Sbjct: 179 PDATTTLDYMLNRQTGILKNLGVFPEKMRHNMDRTYGLIYSQRLLLSLIDAGLSREQAYD 238
Query: 385 LVRQLAMKAFKEGRDLLEVVRKNEEAMKYLTENDLE 420
V+ L +++ E ++V + +LT+ ++
Sbjct: 239 TVQPLTARSWDEQLMFRDLVDADPTITAHLTKAQID 274
>dbj|BAA99412.1| (AB036769) exfoliative toxin C [Staphylococcus aureus]
Length = 278
Score = 207 bits (521), Expect = 2e-52
Identities = 110/275 (40%), Positives = 175/275 (63%), Gaps = 4/275 (1%)
Query: 163 ALWLDEIQRHIERLQQLKDRVLVGKMRGAVGTAASFGDKAFEIEKLVMEDLGLKPARITN 222
ALW E+QR+++R +Q+++ + VGKM GAVGT A+ EIE V + LG+ A ++
Sbjct: 2 ALWYTEMQRNLQRFKQVREEIEVGKMSGAVGTFANIPP---EIESYVCKHLGIGTAPVST 58
Query: 223 QIIQRDVYAELMFFLALVASTLDKMALEIRNLQRTEILEVSEPFGEKQVGSSTMPHKRNP 282
Q +QRD +A + LAL+A++L+K A+EIRNLQ+TE EV E F + Q GSS MPHKRNP
Sbjct: 59 QTLQRDRHAYYIATLALIATSLEKFAVEIRNLQKTETREVEEAFAKGQKGSSAMPHKRNP 118
Query: 283 IRTEKVCGLARVLYSNVIPALLNNPLWHERDLTNSSVERVILPESFVLLDEMLKVMKKVL 342
I +E + G++RV+ + A N PLWHERD+++SS ER++LP+ + LD L ++
Sbjct: 119 IGSENITGISRVIRGYITTAYENVPLWHERDISHSSAERIMLPDVTIALDYALNRFTNIV 178
Query: 343 KGLEFFPENIKRNLYLTKNLIMAEPLMLKLAEKGMGRQEAHELVRQLAMKAFKEGRDLLE 402
L F +N++ N+ T LI ++ ++L L KGM R+EA++ V+ AM +++ E
Sbjct: 179 DRLTVFEDNMRNNIDKTFGLIFSQRVLLALINKGMVREEAYDKVQPKAMISWETKTPFRE 238
Query: 403 VVRKNEEAMKYLTENDL-EGLKPENYIGKAREIVE 436
++ ++E LT+ +L E P++++ + I E
Sbjct: 239 LIEQDESITSVLTKEELDECFDPKHHLNQVDTIFE 273
>sp|Q59092|PCAB_ACICA 3-CARBOXY-CIS,CIS-MUCONATE CYCLOISOMERASE (3-CARBOXYMUCONATE
LACTONIZING ENZYME) (CMLE) >gi|141778|gb|AAC37149.1|
(L05770) beta-carboxy-cis,cis-muconate cycloisomerase
[Acinetobacter sp. ADP1] >gi|1095057|prf||2107260D
carboxymuconate cycloisomerase [Acinetobacter
calcoaceticus]
Length = 452
Score = 202 bits (508), Expect = 8e-51
Identities = 137/439 (31%), Positives = 227/439 (51%), Gaps = 20/439 (4%)
Query: 14 EMRRVWEEENKLQKLLDVEAALARAHAKLGNIPEESA---RVISERANTKWVKLERVKEI 70
++ ++ + + +++ E ALA+ A++G IP+ +A R ++ + + +
Sbjct: 13 DVTEIFSDRALVSYMVEAEVALAQQQAQVGVIPQSAANCDRTCQQKTAIDKIDFDALATA 72
Query: 71 EAEIHHDIMAVVKALSEVCGEH----GKYVHLGATSNDIIDTANALLIKESLAIVEKDLK 126
+ + VK L+ + + +YVH GATS DI+DTA L +++LAIV+ ++
Sbjct: 73 TGLAGNIAIPFVKQLTAIVKDADEDAARYVHWGATSQDILDTACILQCRDALAIVQNQVQ 132
Query: 127 ELRSILKELAKKHIDTVCIGRTHGQHAVPTTYGMKFALWLDEIQRHIERLQQLKDRVLVG 186
+ A+ + V +GRT Q A+P T G K A W +R ++R+ +K RVLV
Sbjct: 133 QCYETALSQAQTYRHQVMMGRTWLQQALPITLGHKLARWASAFKRDLDRINAIKARVLVA 192
Query: 187 KMRGAVGTAASFGDKAFEIEKLVMEDLGLKPARITNQIIQRDVYAELMFFLALVASTLDK 246
++ GAVG+ AS D+ + + + L L T +RD E+ L ++ + K
Sbjct: 193 QLGGAVGSLASLQDQGSIVVEAYAKQLKLGQTACTWH-GERDRIVEIASVLGIITGNVGK 251
Query: 247 MALEIRNLQRTEILEVSEPFGEKQVGSSTMPHKRNPIRTEKVCGLARVLYSNVIPALLNN 306
MA + + +TEI EV EP + + GSSTMPHKRNP+ V A N +PAL+++
Sbjct: 252 MARDWSLMMQTEIAEVFEPTAKGRGGSSTMPHKRNPVAAASVLAAA-----NRVPALMSS 306
Query: 307 PLW-----HERDLTNSSVERVILPESFVLLDEMLKVMKKVLKGLEFFPENIKRNLYLTKN 361
HER L E + LPE F L L+ VLKG+E EN+ +N+ T
Sbjct: 307 IYQSMVQEHERSLGAWHAEWLSLPEIFQLTAGALERTLDVLKGMEVNAENMHQNIECTHG 366
Query: 362 LIMAEPLMLKLAEKGMGRQEAHELVRQLAMKAFKEGRDLLEVVRKNEEAMKYLTENDLEG 421
LIMAE +M+ LA MGR AH +V A E + L +++ + +E +Y + L+
Sbjct: 367 LIMAEAVMMALAPH-MGRLNAHHVVEAACKTAVAEQKHLKDIISQVDEVKQYFNPSQLDE 425
Query: 422 L-KPENYIGKAREIVENVV 439
+ KPE+Y+G ++ ++ V+
Sbjct: 426 IFKPESYLGNIQDQIDAVL 444
>gi|6323391 Adenylosuccinate Lyase; Ade13p [Saccharomyces cerevisiae]
>gi|6093859|sp|Q05911|PUR8_YEAST ADENYLOSUCCINATE LYASE
(ADENYLOSUCCINASE) (ASL) (ASASE) >gi|1077357|pir||S51377
probable membrane protein YLR359w - yeast (Saccharomyces
cerevisiae) >gi|609416|gb|AAB67573.1| (U19103) Ade13p:
adenylsuccinate lyase [Saccharomyces cerevisiae]
Length = 482
Score = 201 bits (505), Expect = 2e-50
Identities = 140/452 (30%), Positives = 231/452 (50%), Gaps = 20/452 (4%)
Query: 5 PIDYRYGSEEMRRVWEEENKLQKLLDVEAALARAHAKLGN--IPEESARVISERANTKWV 62
P+ RY S+EM + N+ + LA A +LG + +E+ + +
Sbjct: 10 PLSSRYASKEMSATFSLRNRFSTWRKLWLNLAIAEKELGLTVVTDEAIEQMRKHVEITDD 69
Query: 63 KLERVKEIEAEIHHDIMAVVKALSEVCGEHGKYVHLGATSNDIIDTANALLIKESLAIVE 122
++ + EA + HD+MA V E C +HLGATS + D A+ + I+++ I+
Sbjct: 70 EIAKASAQEAIVRHDVMAHVHTFGETCPAAAGIIHLGATSCFVTDNADLIFIRDAYDIII 129
Query: 123 KDLKELRSILKELAKKHIDTVCIGRTHGQHAVPTTYGMKFALWLDEIQRHIERLQQLKDR 182
L + + L + A ++ D +G TH Q A TT G + LW+ E+ + ++ ++
Sbjct: 130 PKLVNVINRLAKFAMEYKDLPVLGWTHFQPAQLTTLGKRATLWIQELLWDLRNFERARND 189
Query: 183 VLVGKMRGAVGTAASF-------GDKAFEIEKLVMEDLGL-KPARITNQIIQRDVYAELM 234
+ + ++G GT ASF DK +++ V E LG K +T Q R + +++
Sbjct: 190 IGLRGVKGTTGTQASFLALFHGNHDKVEALDERVTELLGFDKVYPVTGQTYSRKIDIDVL 249
Query: 235 FFLALVASTLDKMALEIRNLQRTEILEVSEPFGEKQVGSSTMPHKRNPIRTEKVCGLARV 294
L+ A+T KMA +IR L + EV EPF + Q+GSS M +KRNP+R E+VC LAR
Sbjct: 250 APLSSFAATAHKMATDIRLL--ANLKEVEEPFEKSQIGSSAMAYKRNPMRCERVCSLARH 307
Query: 295 LYSNVIPALLNNPL-WHERDLTNSSVERVILPESFVLLDEMLKVMKKVLKGLEFFPENIK 353
L S A+ + W ER L +S++ R+ LP +F+ D +L + + GL +P+ I+
Sbjct: 308 LGSLFSDAVQTASVQWFERTLDDSAIRRISLPSAFLTADILLSTLLNISSGLVVYPKVIE 367
Query: 354 RNLYLTKNLIMAEPLMLKLAEKGMGRQEAHELVRQLAMKAF----KEG--RDLLEVVRKN 407
R + + E +++ + EK RQE HE +R L+ +A +EG DL+E V K
Sbjct: 368 RRIKGELPFMATENIIMAMVEKNASRQEVHERIRVLSHQAAAVVKEEGGENDLIERV-KR 426
Query: 408 EEAMKYLTENDLEGLKPENYIGKAREIVENVV 439
+E K + E L+P ++G+A + VE V
Sbjct: 427 DEFFKPIWEELDSLLEPSTFVGRAPQQVEKFV 458
>gb|AAC83935.1| (AF106656) adenylosuccinate lyase [Homo sapiens]
Length = 484
Score = 200 bits (504), Expect = 2e-50
Identities = 134/446 (30%), Positives = 235/446 (52%), Gaps = 17/446 (3%)
Query: 5 PIDYRYGSEEMRRVWEEENKLQKLLDVEAALARAHAKLGNIPEESARVISERANTKWVKL 64
P+ RY S EM V+ + K + + LA A LG +P ++ ++N + +
Sbjct: 16 PLASRYASPEMCFVFSDRYKFRTWRQLWLWLAEAEQTLG-LPITDEQIQEMKSNLENIDF 74
Query: 65 ERVKEIEAEIHHDIMAVVKALSEVCGEHGKYVHLGATSNDIIDTANALLIKESLAIVEKD 124
+ E E + HD+MA V C + +HLGATS + D + ++++ +L ++
Sbjct: 75 KMAAEEEKRLRHDVMAHVHTFGHCCPKAAGIIHLGATSCYVGDNTDLIILRNALDLLLPK 134
Query: 125 LKELRSILKELAKKHIDTVCIGRTHGQHAVPTTYGMKFALWLDEIQRHIERLQQLKDRVL 184
L + S L + AK+ +G TH Q A TT G + LW+ ++ ++ L++++D +
Sbjct: 135 LARVISRLADFAKERASLPTLGFTHFQPAQLTTVGKRCCLWIQDLCMDLQNLKRVRDDLR 194
Query: 185 VGKMRGAVGTAASF-----GD--KAFEIEKLVMEDLGLKPA-RITNQIIQRDVYAELMFF 236
++G GT ASF GD K +++K+V E G K A IT Q R V E++
Sbjct: 195 FRGVKGTTGTQASFLQLFEGDDHKVEQLDKMVTEKAGFKRAFIITGQTYTRKVDIEVLSV 254
Query: 237 LALVASTLDKMALEIRNLQRTEILEVSEPFGEKQVGSSTMPHKRNPIRTEKVCGLARVLY 296
LA + +++ K+ +IR L + E+ EPF ++Q+GSS MP+KRNP+R+E+ C LAR L
Sbjct: 255 LASLGASVHKICTDIRLL--ANLKEIEEPFEKQQIGSSAMPYKRNPMRSERCCSLARHLM 312
Query: 297 SNVI-PALLNNPLWHERDLTNSSVERVILPESFVLLDEMLKVMKKVLKGLEFFPENIKRN 355
+ V+ P + W ER L +S+ R+ L E+F+ D +L ++ + +GL +P+ I+R
Sbjct: 313 TLVMDPLQTASVQWFERTLDDSANRRICLAEAFLTADTILNTLQNISEGLVVYPKVIERR 372
Query: 356 LYLTKNLIMAEPLMLKLAEKGMGRQEAHELVRQLAMKAF----KEGRDLLEVVRKNEEAM 411
+ + E +++ + + G RQ+ HE +R L+ +A +EG D + R +A
Sbjct: 373 IRQELPFMATENIIMAMVKAGGSRQDCHEKIRVLSQQAASVVKQEGGDNDLIERIQVDAY 432
Query: 412 KYLTENDLEG-LKPENYIGKAREIVE 436
+ L+ L P ++ G+A + V+
Sbjct: 433 FSPIHSQLDHLLDPSSFTGRASQQVQ 458
>gi|6752996 adenylosuccinate lyase [Mus musculus]
>gi|1709933|sp|P54822|PUR8_MOUSE ADENYLOSUCCINATE LYASE
(ADENYLOSUCCINASE) (ASL) (ASASE)
>gi|717127|gb|AAB60684.1| (U20225) adenylosuccinate
lyase [Mus musculus]
Length = 484
Score = 199 bits (502), Expect = 4e-50
Identities = 138/457 (30%), Positives = 235/457 (51%), Gaps = 20/457 (4%)
Query: 5 PIDYRYGSEEMRRVWEEENKLQKLLDVEAALARAHAKLGNIPEESARVISERANTKWVKL 64
P+ RY S EM ++ + K Q + LA A LG +P ++ ++N +
Sbjct: 16 PLAARYASREMCFLFSDRYKFQTWRQLWLWLAEAEQTLG-LPITDEQIQEMKSNLNNIDF 74
Query: 65 ERVKEIEAEIHHDIMAVVKALSEVCGEHGKYVHLGATSNDIIDTANALLIKESLAIVEKD 124
+ E E + HD+MA V C + +HLGATS + D + ++++ + ++
Sbjct: 75 QMAAEEEKRLRHDVMAHVHTFGHCCPKAAGIIHLGATSCYVGDNTDLIILRNAFDLLLPK 134
Query: 125 LKELRSILKELAKKHIDTVCIGRTHGQHAVPTTYGMKFALWLDEIQRHIERLQQLKDRVL 184
L + S L + AK D +G TH Q A TT G + LW+ + ++ L++++D V
Sbjct: 135 LARVISRLADFAKDRADLPTLGFTHFQPAQLTTVGKRCCLWIQDSVMDLQNLKRVRDDVR 194
Query: 185 VGKMRGAVGTAASF-----GD--KAFEIEKLVMEDLGLKPA-RITNQIIQRDVYAELMFF 236
++G GT ASF GD K +++K+V E G K A IT Q R V E++
Sbjct: 195 FRGVKGTTGTQASFLQLFEGDHQKVEQLDKMVTEKAGFKRAFIITGQTYTRKVDIEVLSV 254
Query: 237 LALVASTLDKMALEIRNLQRTEILEVSEPFGEKQVGSSTMPHKRNPIRTEKVCGLARVLY 296
LA + +++ K+ +IR L + E+ EPF ++Q+GSS MP+KRNP+R+E+ C LAR L
Sbjct: 255 LASLGASVHKICTDIRLL--ANLKEMEEPFEKQQIGSSAMPYKRNPMRSERCCSLARHLM 312
Query: 297 S-NVIPALLNNPLWHERDLTNSSVERVILPESFVLLDEMLKVMKKVLKGLEFFPENIKRN 355
+ + P + W ER L +S+ R+ L E+F+ D +L ++ + +GL +P+ I+R
Sbjct: 313 ALTMDPLQTASVQWFERTLDDSANRRICLAEAFLTADTILNTLQNISEGLVVYPKVIERR 372
Query: 356 LYLTKNLIMAEPLMLKLAEKGMGRQEAHELVRQLAMKAF----KEGRDLLEVVRKNEEAM 411
+ + E +++ + + G RQ+ HE +R L+ +A +EG D + R +A
Sbjct: 373 IRQELPFMATENIIMAMVKAGGSRQDCHEKIRVLSQQAAAVVKQEGGDNDLIERIRADAY 432
Query: 412 KYLTENDLEG-LKPENYIGKAREIVENVVNYVEEMER 447
+ LE L P ++ G+A + V ++EE R
Sbjct: 433 FSPIHSQLEHLLDPSSFTGRA---PQQVHRFLEEEVR 466
>gi|4557269 adenylosuccinate lyase; adenylosuccinase [Homo sapiens]
>gi|11418165|ref|XP_010008.1| adenylosuccinate lyase
[Homo sapiens] >gi|6686318|sp|P30566|PUR8_HUMAN
ADENYLOSUCCINATE LYASE (ADENYLOSUCCINASE) (ASL) (ASASE)
>gi|28904|emb|CAA46696.1| (X65867) adenylosuccinate
lyase [Homo sapiens] >gi|3211982|gb|AAC21560.1|
(AF067853) adenylosuccinate lyase [Homo sapiens]
Length = 484
Score = 199 bits (502), Expect = 4e-50
Identities = 134/446 (30%), Positives = 235/446 (52%), Gaps = 17/446 (3%)
Query: 5 PIDYRYGSEEMRRVWEEENKLQKLLDVEAALARAHAKLGNIPEESARVISERANTKWVKL 64
P+ RY S EM V+ + K + + LA A LG +P ++ ++N + +
Sbjct: 16 PLASRYASPEMCFVFSDRYKFRTWRQLWLWLAEAEQTLG-LPITDEQIQEMKSNLENIDF 74
Query: 65 ERVKEIEAEIHHDIMAVVKALSEVCGEHGKYVHLGATSNDIIDTANALLIKESLAIVEKD 124
+ E E + HD+MA V C + +HLGATS + D + ++++ +L ++
Sbjct: 75 KMAAEEEKRLRHDVMAHVHTFGHCCPKAAGIIHLGATSCYVGDNTDLIILRNALDLLLPK 134
Query: 125 LKELRSILKELAKKHIDTVCIGRTHGQHAVPTTYGMKFALWLDEIQRHIERLQQLKDRVL 184
L + S L + AK+ +G TH Q A TT G + LW+ ++ ++ L++++D +
Sbjct: 135 LARVISRLADFAKERASLPTLGFTHFQPAQLTTVGKRCCLWIQDLCMDLQNLKRVRDDLR 194
Query: 185 VGKMRGAVGTAASF-----GD--KAFEIEKLVMEDLGLKPA-RITNQIIQRDVYAELMFF 236
++G GT ASF GD K +++K+V E G K A IT Q R V E++
Sbjct: 195 FRGVKGTTGTQASFLQLFEGDDHKVEQLDKMVTEKAGFKRAFIITGQTYTRKVDIEVLSV 254
Query: 237 LALVASTLDKMALEIRNLQRTEILEVSEPFGEKQVGSSTMPHKRNPIRTEKVCGLARVLY 296
LA + +++ K+ +IR L + E+ EPF ++Q+GSS MP+KRNP+R+E+ C LAR L
Sbjct: 255 LASLGASVHKICTDIRLL--ANLKEMEEPFEKQQIGSSAMPYKRNPMRSERCCSLARHLM 312
Query: 297 SNVI-PALLNNPLWHERDLTNSSVERVILPESFVLLDEMLKVMKKVLKGLEFFPENIKRN 355
+ V+ P + W ER L +S+ R+ L E+F+ D +L ++ + +GL +P+ I+R
Sbjct: 313 TLVMDPLQTASVQWFERTLDDSANRRICLAEAFLTADTILNTLQNISEGLVVYPKVIERR 372
Query: 356 LYLTKNLIMAEPLMLKLAEKGMGRQEAHELVRQLAMKAF----KEGRDLLEVVRKNEEAM 411
+ + E +++ + + G RQ+ HE +R L+ +A +EG D + R +A
Sbjct: 373 IRQELPFMATENIIMAMVKAGGSRQDCHEKIRVLSQQAASVVKQEGGDNDLIERIQVDAY 432
Query: 412 KYLTENDLEG-LKPENYIGKAREIVE 436
+ L+ L P ++ G+A + V+
Sbjct: 433 FSPIHSQLDHLLDPSSFTGRASQQVQ 458
>sp|O31385|PCAB_BRAJA 3-CARBOXY-CIS,CIS-MUCONATE CYCLOISOMERASE (3-CARBOXYMUCONATE
LACTONIZING ENZYME) (CMLE) >gi|2239059|emb|CAA71270.1|
(Y10223) 3-carboxy-cis,cis-muconate cycloisomerase
[Bradyrhizobium japonicum]
Length = 451
Score = 198 bits (497), Expect = 1e-49
Identities = 134/440 (30%), Positives = 222/440 (50%), Gaps = 13/440 (2%)
Query: 12 SEEMRRVWEEENKLQKLLDVEAALARAHAKLGNIPEESARVISERANTKWVKLERVKEIE 71
S MR ++ + LQ +LD EAALARA A G IP + I + + E
Sbjct: 15 SAAMRAACDDRSTLQNMLDFEAALARAEAATGVIPAAAVGPIETACKAATFDIAALAEAA 74
Query: 72 AEIHHDIMAVVKALS----EVCGEHGKYVHLGATSNDIIDTANALLIKESLAIVEKDLKE 127
+ + +VKAL+ + E +YVH GATS D+IDTA L ++ ++ ++ DL
Sbjct: 75 TRSGNLAIPLVKALTANVAKADAEAARYVHWGATSQDVIDTATMLTLRAAIDALDADLSR 134
Query: 128 LRSILKELAKKHIDTVCIGRTHGQHAVPTTYGMKFALWLDEIQRHIERLQQLKDRVLVGK 187
LA+ H +T + RT QHA+P +G+K A + + R RL++L L +
Sbjct: 135 AIKGFAALARNHRNTAMVARTWLQHALPMPFGLKAAEYAASLARARCRLRRLSRDGLALQ 194
Query: 188 MRGAVGTAASFGDKAFEIEKLVMEDLGLKPARITNQIIQRDVYAELMFFLALVASTLDKM 247
GA GT A+ GDK + + + ++L L P RD AE LA++A + K+
Sbjct: 195 FGGAAGTLAALGDKGLVVAERLAQELNL-PLPEAPWHTHRDRIAEAASALAILAGSCGKI 253
Query: 248 ALEIRNLQRTEILEVSEPFGEKQVGSSTMPHKRNPIRTEKVCGLARV---LYSNVIPALL 304
A ++ + +T++ E EP GE + GSSTMPHKRNP+ G A + L + + A +
Sbjct: 254 ARDVSLMMQTDVAEAFEPAGEGRGGSSTMPHKRNPVAAASALGCATMAPQLAATIFAAQV 313
Query: 305 NNPLWHERDLTNSSVERVILPESFVLLDEMLKVMKKVLKGLEFFPENIKRNLYLTKNLIM 364
+ HER E LP+ ++ L + + +GL+ ++ NL T LIM
Sbjct: 314 QD---HERSAGPWHAEWPTLPQLMLVTSGALAAIVDIAEGLDVDAARMRSNLDATHGLIM 370
Query: 365 AEPLMLKLAEKGMGRQEAHELVRQLAMKAFKEGRDLLEVVRKNEEAMKYLTENDLEGL-K 423
AE + LAE+ +G+ +AH L+ + +A E + L EV+ + + +L+ + L +
Sbjct: 371 AEAVTFALAER-IGKSDAHHLIEAASKRAVAEKKHLREVLAADSQVTAHLSPEKIAALFE 429
Query: 424 PENYIGKAREIVENVVNYVE 443
P Y G ++ +++ +++ +E
Sbjct: 430 PMAYQGASQAMIDRLLDSLE 449
>sp|P32427|PCAB_PSEPU 3-CARBOXY-CIS,CIS-MUCONATE CYCLOISOMERASE (3-CARBOXYMUCONATE
LACTONIZING ENZYME) (CMLE) >gi|321703|pir||A44374
3-carboxy-cis,cis-muconate cycloisomerase (EC 5.5.1.2) -
Pseudomonas putida >gi|309876|gb|AAA25920.1| (L17082)
3-carboxy-cis,cis-muconate cycloisomerase [Pseudomonas
putida]
Length = 407
Score = 197 bits (495), Expect = 3e-49
Identities = 131/372 (35%), Positives = 190/372 (50%), Gaps = 7/372 (1%)
Query: 7 DYRYGSEEMRRVWEEENKLQKLLDVEAALARAHAKLGNIPEESARVISERANTKWVKLER 66
D + + MR ++ + +LQ +LD EAALARA A G +P + I + +
Sbjct: 7 DAYFTAPAMREIFSDRGRLQGMLDFEAALARAEAAAGLVPHSAVAAIEAACKAERYDVGA 66
Query: 67 VKEIEAEIHHDIMAVVKALSEVCG----EHGKYVHLGATSNDIIDTANALLIKESLAIVE 122
+ A + + +VKAL +V E +YVHLGATS D +DT L ++++L ++E
Sbjct: 67 LANAIATAGNSAIPLVKALGKVIASGVPEAERYVHLGATSQDAMDTGLVLQLRDALDLIE 126
Query: 123 KDLKELRSILKELAKKHIDTVCIGRTHGQHAVPTTYGMKFALWLDEIQRHIERLQQLKDR 182
DL +L L + A KH DT +GRT QHA P T GMK A L + RH +RLQ+L
Sbjct: 127 ADLGKLADTLSQQALKHADTPMVGRTWLQHATPVTLGMKLAGVLGALTRHRQRLQELGPP 186
Query: 183 VLVGKMRGAVGTAASFGDKAFEIEKLVMEDLGLK-PARITNQIIQRDVYAELMFFLALVA 241
GA G+ A+ G KA + + + E L L P + + QRD E L LVA
Sbjct: 187 CWCCSSGGASGSLAALGSKAMPVAEALAEQLKLSLPEQPWH--TQRDRLVEFASVLGLVA 244
Query: 242 STLDKMALEIRNLQRTEILEVSEPFGEKQVGSSTMPHKRNPIRTEKVCGLARVLYSNVIP 301
+L K ++ L +TE EV EP + GSSTMPHKRNP+ + G A + V
Sbjct: 245 GSLGKFGRDVSLLMQTEAGEVFEPSAPGKGGSSTMPHKRNPVGAAVLIGAATRVPGLVST 304
Query: 302 ALLNNPLWHERDLTNSSVERVILPESFVLLDEMLKVMKKVLKGLEFFPENIKRNLYLTKN 361
P HER L E LP+ L+ L+ + + +G+E ++RNL LT+
Sbjct: 305 LFAAMPQEHERSLGLWHAEWETLPDICCLVSGALRQAQVIAEGIEVDAARMRRNLDLTQG 364
Query: 362 LIMAEPLMLKLA 373
L++AE + + LA
Sbjct: 365 LVLAEAVSIVLA 376
>pir||I58109 adenylosuccinate lyase - human >gi|28905|emb|CAA46697.1| (X65867)
adenylosuccinate lyase [Homo sapiens]
>gi|300302|gb|AAC60603.1| (S60710) adenylosuccinate
lyase, ASL {EC 4.3.2.2} [human, liver, Peptide, 459 aa]
[Homo sapiens] >gi|4176444|emb|CAA18264.1| (AL022238)
dJ1042K10.1 (Adenylosuccinate lyase (EC 4.3.2.2,
Adenylosuccinase, ASL)) [Homo sapiens]
>gi|229004|prf||1815238A adenylosuccinate lyase [Homo
sapiens]
Length = 459
Score = 190 bits (478), Expect = 3e-47
Identities = 126/416 (30%), Positives = 222/416 (53%), Gaps = 17/416 (4%)
Query: 35 LARAHAKLGNIPEESARVISERANTKWVKLERVKEIEAEIHHDIMAVVKALSEVCGEHGK 94
LA A LG +P ++ ++N + + + E E + HD+MA V C +
Sbjct: 21 LAEAEQTLG-LPITDEQIQEMKSNLENIDFKMAAEEEKRLRHDVMAHVHTFGHCCPKAAG 79
Query: 95 YVHLGATSNDIIDTANALLIKESLAIVEKDLKELRSILKELAKKHIDTVCIGRTHGQHAV 154
+HLGATS + D + ++++ +L ++ L + S L + AK+ +G TH Q A
Sbjct: 80 IIHLGATSCYVGDNTDLIILRNALDLLLPKLARVISRLADFAKERASLPTLGFTHFQPAQ 139
Query: 155 PTTYGMKFALWLDEIQRHIERLQQLKDRVLVGKMRGAVGTAASF-----GD--KAFEIEK 207
TT G + LW+ ++ ++ L++++D + ++G GT ASF GD K +++K
Sbjct: 140 LTTVGKRCCLWIQDLCMDLQNLKRVRDDLRFRGVKGTTGTQASFLQLFEGDDHKVEQLDK 199
Query: 208 LVMEDLGLKPA-RITNQIIQRDVYAELMFFLALVASTLDKMALEIRNLQRTEILEVSEPF 266
+V E G K A IT Q R V E++ LA + +++ K+ +IR L + E+ EPF
Sbjct: 200 MVTEKAGFKRAFIITGQTYTRKVDIEVLSVLASLGASVHKICTDIRLL--ANLKEMEEPF 257
Query: 267 GEKQVGSSTMPHKRNPIRTEKVCGLARVLYSNVI-PALLNNPLWHERDLTNSSVERVILP 325
++Q+GSS MP+KRNP+R+E+ C LAR L + V+ P + W ER L +S+ R+ L
Sbjct: 258 EKQQIGSSAMPYKRNPMRSERCCSLARHLMTLVMDPLQTASVQWFERTLDDSANRRICLA 317
Query: 326 ESFVLLDEMLKVMKKVLKGLEFFPENIKRNLYLTKNLIMAEPLMLKLAEKGMGRQEAHEL 385
E+F+ D +L ++ + +GL +P+ I+R + + E +++ + + G RQ+ HE
Sbjct: 318 EAFLTADTILNTLQNISEGLVVYPKVIERRIRQELPFMATENIIMAMVKAGGSRQDCHEK 377
Query: 386 VRQLAMKAF----KEGRDLLEVVRKNEEAMKYLTENDLEG-LKPENYIGKAREIVE 436
+R L+ +A +EG D + R +A + L+ L P ++ G+A + V+
Sbjct: 378 IRVLSQQAASVVKQEGGDNDLIERIQVDAYFSPIHSQLDHLLDPSSFTGRASQQVQ 433
>sp|P21265|PUR8_CHICK ADENYLOSUCCINATE LYASE (ADENYLOSUCCINASE) (ASL) (ASASE)
>gi|104525|pir||A35291 adenylosuccinate lyase (EC
4.3.2.2) - chicken >gi|211095|gb|AAA48574.1| (M37901)
adynylosuccinate lyase [Gallus gallus]
Length = 459
Score = 189 bits (476), Expect = 4e-47
Identities = 128/430 (29%), Positives = 222/430 (50%), Gaps = 20/430 (4%)
Query: 35 LARAHAKLGNIPEESARVISERANTKWVKLERVKEIEAEIHHDIMAVVKALSEVCGEHGK 94
LA+A LG +P ++ AN + + E E ++ HD+MA V + C +
Sbjct: 21 LAQAEKSLG-LPITDEQIKEMEANLDNIDFKMAAEEEKKLRHDVMAHVHTFAHCCPKAAA 79
Query: 95 YVHLGATSNDIIDTANALLIKESLAIVEKDLKELRSILKELAKKHIDTVCIGRTHGQHAV 154
+HLGATS + D + +++++ ++ L + S L + A+ H D +G TH Q A
Sbjct: 80 IIHLGATSCYVGDNTDLIVLRDGFNLLLPKLARVISRLADFAETHADLPTLGFTHYQPAQ 139
Query: 155 PTTYGMKFALWLDEIQRHIERLQQLKDRVLVGKMRGAVGTAASF-----GD--KAFEIEK 207
TT G + LW+ ++ ++ L++ +D + ++G GT ASF GD K E+++
Sbjct: 140 LTTVGKRCCLWIQDLCMDLQNLERARDDLRFRGVKGTTGTQASFLQLFEGDHSKVEELDR 199
Query: 208 LVMEDLGLKPA-RITNQIIQRDVYAELMFFLALVASTLDKMALEIRNLQRTEILEVSEPF 266
LV G K + +T Q R V E++ LA + +++ K+ +IR L + E+ EPF
Sbjct: 200 LVTAKAGFKRSYMVTGQTYSRKVDIEVLSVLASLGASVHKICTDIRLL--ANLKEIEEPF 257
Query: 267 GEKQVGSSTMPHKRNPIRTEKVCGLARVLYSNVI-PALLNNPLWHERDLTNSSVERVILP 325
+ Q+GSS MP+KRNP+R+E+ C LAR L + V+ P + W ER L +S+ RV L
Sbjct: 258 EKDQIGSSAMPYKRNPMRSERCCSLARHLMTLVLDPLQTASVQWFERTLDDSANRRVCLA 317
Query: 326 ESFVLLDEMLKVMKKVLKGLEFFPENIKRNLYLTKNLIMAEPLMLKLAEKGMGRQEAHEL 385
E+F+ D +L ++ + +GL +P+ I R + + E +++ + + G RQ+ HE
Sbjct: 318 EAFLTADIILSTLQNISEGLVVYPKVIDRRIRQELPFMATENIIMAMVKAGGNRQDCHEK 377
Query: 386 VRQLAMKAF----KEGRDLLEVVRKNEEAMKYLTENDLEG-LKPENYIGKAREIVENVVN 440
+R L+ +A +EG D + R + L+ L P ++ G+A + V
Sbjct: 378 IRVLSQQAAAVVKQEGGDNDFIARVRADPYFSPIHEHLDSLLDPSSFTGRA---PQQVAK 434
Query: 441 YVEEMERRGL 450
+++E R L
Sbjct: 435 FLKEEVRPAL 444
>pir||T47114 probable 3-carboxy-cis,cis-muconate cycloisomerase (EC 5.5.1.2)
[imported] - Streptomyces sp
>gi|5209339|gb|AAD40814.1|AF109386_6 (AF109386)
3-carboxymuconate cycloisomerase; PcaB [Streptomyces sp.
2065]
Length = 444
Score = 189 bits (476), Expect = 4e-47
Identities = 143/427 (33%), Positives = 220/427 (51%), Gaps = 28/427 (6%)
Query: 25 LQKLLDVEAALARAHAKLGNIPEESARVISERANTKWVKLERVKEIEAEIHHDIMAVVKA 84
L+ LLD E+AL RA A LG P E+A ++ A+ + + E + ++ +V
Sbjct: 31 LRALLDAESALTRAQAALGLAPAEAATAVTAAADPDRFDVRSLAERSRAGGNPVIPLVAD 90
Query: 85 LSEVCGE-HGKYVHLGATSNDIIDTANALLIKESLAIVEKDLKELRSILKELAKKHIDTV 143
L++ GE +G YVH GATS DI+DTA L+ +L +V DL L LA H DT
Sbjct: 91 LTKAVGEEYGPYVHRGATSQDIMDTATMLVASRTLDLVLTDLTRTAQALARLAAAHRDTA 150
Query: 144 CIGRTHGQHAVPTTYGMKFALWLDEIQRHIERLQQLKDRVLVGKMRGAVGTAASF----G 199
GRT QHAVPTT+G+K A W + +R++ ++D + V ++ GA GT A+F
Sbjct: 151 MPGRTLTQHAVPTTFGLKAAGWRSLVLDARDRVRAVRDTLPV-QLGGAAGTLAAFTAYGA 209
Query: 200 DKAFEIEKLVMEDLGLKPARITNQIIQRDVYAELMFFLALVASTLDKMALEIRNLQRTEI 259
+ A + +LGL ++ ++ + A+L LA A L K+A ++ L RTEI
Sbjct: 210 EDALALPDAYARELGLTAPQLPWHTLRTPI-ADLAGCLAFAAGALGKVAADVLVLGRTEI 268
Query: 260 LEVSEPFGEKQVGSSTMPHKRNPIRTEKVCGLAR-------VLYSNVIPALLNNPLWHER 312
EVSE G GSS MPHK NP+R+ + AR VLY +++ +ER
Sbjct: 269 AEVSEGSGG---GSSAMPHKANPVRSTLIAAAARRAPQLAAVLYGSLVAE-------NER 318
Query: 313 DLTNSSVERVILPESFVLLDEMLKVMKKVLKGLEFFPENIKRNLYLTKNLIMAEPLMLKL 372
E L E L+ + ++ +GL P+ ++ +L LT LI++E L +L
Sbjct: 319 PAGAWHAEWEPLRELLRLVGGAARDAVELAEGLRVHPDVMREHLDLTHGLIVSERLSAEL 378
Query: 373 AEKGMGRQEAHELVRQLAMKAFKEGRDLLEVVRKNEEAMKYLTENDLEGLKPENYIGKAR 432
A + +GR A EL+ ++A + + EGR L E++ + E +K L +DL P Y G A
Sbjct: 379 APR-LGRTRAKELLTEVARRTYAEGRPLAELLAEEPE-LKDLDLSDL--TDPARYTGSAG 434
Query: 433 EIVENVV 439
+ + +
Sbjct: 435 ALTDRAL 441
>gb|AAC21561.1| (AF067854) adenylosuccinate lyase [Homo sapiens]
>gi|4176445|emb|CAA18265.1| (AL022238) dJ1042K10.1
(isoform 2) [Homo sapiens]
Length = 425
Score = 185 bits (465), Expect = 8e-46
Identities = 118/385 (30%), Positives = 205/385 (52%), Gaps = 12/385 (3%)
Query: 5 PIDYRYGSEEMRRVWEEENKLQKLLDVEAALARAHAKLGNIPEESARVISERANTKWVKL 64
P+ RY S EM V+ + K + + LA A LG +P ++ ++N + +
Sbjct: 16 PLASRYASPEMCFVFSDRYKFRTWRQLWLWLAEAEQTLG-LPITDEQIQEMKSNLENIDF 74
Query: 65 ERVKEIEAEIHHDIMAVVKALSEVCGEHGKYVHLGATSNDIIDTANALLIKESLAIVEKD 124
+ E E + HD+MA V C + +HLGATS + D + ++++ +L ++
Sbjct: 75 KMAAEEEKRLRHDVMAHVHTFGHCCPKAAGIIHLGATSCYVGDNTDLIILRNALDLLLPK 134
Query: 125 LKELRSILKELAKKHIDTVCIGRTHGQHAVPTTYGMKFALWLDEIQRHIERLQQLKDRVL 184
L + S L + AK+ +G TH Q A TT G + LW+ ++ ++ L++++D +
Sbjct: 135 LARVISRLADFAKERASLPTLGFTHFQPAQLTTVGKRCCLWIQDLCMDLQNLKRVRDDLR 194
Query: 185 VGKMRGAVGTAASF-----GD--KAFEIEKLVMEDLGLKPA-RITNQIIQRDVYAELMFF 236
++G GT ASF GD K +++K+V E G K A IT Q R V E++
Sbjct: 195 FRGVKGTTGTQASFLQLFEGDDHKVEQLDKMVTEKAGFKRAFIITGQTYTRKVDIEVLSV 254
Query: 237 LALVASTLDKMALEIRNLQRTEILEVSEPFGEKQVGSSTMPHKRNPIRTEKVCGLARVLY 296
LA + +++ K+ +IR L + E+ EPF ++Q+GSS MP+KRNP+R+E+ C LAR L
Sbjct: 255 LASLGASVHKICTDIRLL--ANLKEMEEPFEKQQIGSSAMPYKRNPMRSERCCSLARHLM 312
Query: 297 SNVI-PALLNNPLWHERDLTNSSVERVILPESFVLLDEMLKVMKKVLKGLEFFPENIKRN 355
+ V+ P + W ER L +S+ R+ L E+F+ D +L ++ + +GL +P+ I+R
Sbjct: 313 TLVMDPLQTASVQWFERTLDDSANRRICLAEAFLTADTILNTLQNISEGLVVYPKVIERR 372
Query: 356 LYLTKNLIMAEPLMLKLAEKGMGRQ 380
+ + E +++ + + G RQ
Sbjct: 373 IRQELPFMATENIIMAMVKAGGSRQ 397
>gb|AAF55375.1| (AE003715) CG3590 gene product [Drosophila melanogaster]
Length = 481
Score = 185 bits (464), Expect = 1e-45
Identities = 133/459 (28%), Positives = 232/459 (49%), Gaps = 25/459 (5%)
Query: 5 PIDYRYGSEEMRRVWEEENKLQKLLDVEAALARAHAKLGNIPEESARVISERANTKWVKL 64
P+ RY S+EM+ ++ ++NK + LA+A ++LG + A++ +
Sbjct: 11 PLSTRYASKEMQFLFSDQNKFSTWRRLWVWLAKAESRLG-LEISDAQIAEMELQISNIDF 69
Query: 65 ERVKEIEAEIHHDIMAVVKALSEVCGEHGKYVHLGATSNDIIDTANALLIKESLAIVEKD 124
E E HD+MA V ++ C +HLGATS + D + ++++++L ++
Sbjct: 70 EAAAAEERLTRHDVMAHVHVFAKQCPSAAPVIHLGATSCYVGDNTDLIVLRDALKLLLPR 129
Query: 125 LKELRSILKELAKKHIDTVCIGRTHGQHAVPTTYGMKFALWLDEIQRHIERLQQLKDRVL 184
+ + + L + A+ + D +G TH Q A TT G + LW+ ++ L + + +
Sbjct: 130 VASVIARLSQFAQSYKDQPTLGFTHLQPAQLTTVGKRACLWIQDLIMDERALSRCLEDLR 189
Query: 185 VGKMRGAVGTAASF-------GDKAFEIEKLVMEDLGLKPA-RITNQIIQRDVYAELMFF 236
++G GT ASF G+K ++++LV E G K A +T Q R V E++
Sbjct: 190 FRGVKGTTGTQASFLQLFNGDGEKVKQLDQLVTELAGFKKAYAVTGQTYSRKVDVEIVAA 249
Query: 237 LALVASTLDKMALEIRNLQRTEILEVSEPFGEKQVGSSTMPHKRNPIRTEKVCGLAR--- 293
LA + +T+ KM ++R L + E+ EPF Q+GSS MP+KRNP+R+E+ C LAR
Sbjct: 250 LASLGTTIHKMCSDLRILASRK--ELEEPFESTQIGSSAMPYKRNPMRSERCCALARHLI 307
Query: 294 VLYSNVIPALLNNPLWHERDLTNSSVERVILPESFVLLDEMLKVMKKVLKGLEFFPENIK 353
L+S+ A + W ER L +S+ R+ L E+F+ D L + + +GL +P+ I+
Sbjct: 308 TLFSSA--ANTHATQWLERTLDDSANRRLTLSEAFLAADAALLTLLNISQGLVVYPKVIE 365
Query: 354 RNLYLTKNLIMAEPLMLKLAEKGMGRQEAHELVRQLA------MKAFKEGRDLLEVVRKN 407
R++ + E +++ + + G RQ HE +R L+ +K + DL+ VRK+
Sbjct: 366 RHISQELPFMSTENIIMAMVKAGGDRQVCHEKIRVLSQEAGAQVKQHGKDNDLVVRVRKD 425
Query: 408 EEAMKYLTENDLEGLKPENYIGKAREIVENVVNYVEEME 446
L + D L + + G+A + V V EE+E
Sbjct: 426 PYFSPILEQLDTI-LDAKTFTGRASDQVGEFVK--EEVE 461
>sp|O60105|PUR8_SCHPO ADENYLOSUCCINATE LYASE (ADENYLOSUCCINASE) (ASL) (ASASE)
>gi|7490082|pir||T39455 adenylosuccinate lyase - fission
yeast (Schizosaccharomyces pombe)
>gi|3184112|emb|CAA19327.1| (AL023780) adenylosuccinate
lyase [Schizosaccharomyces pombe]
Length = 482
Score = 183 bits (460), Expect = 3e-45
Identities = 132/454 (29%), Positives = 225/454 (49%), Gaps = 22/454 (4%)
Query: 5 PIDYRYGSEEMRRVWEEENKLQKLLDVEAALARAHAKLG--NIPEESARVISERANTKWV 62
P+ RY S EM ++ E ++ + LA A +LG I +E+ +
Sbjct: 10 PLTARYASAEMSHLFSREMRINTWRQLWLNLAIAEKQLGLTQITDEAIEQLKAHVKITAP 69
Query: 63 KLERVKEIEAEIHHDIMAVVKALSEVCGEHGKYVHLGATSNDIIDTANALLIKESLAIVE 122
+ E + E HD+MA + +HLGATS + D A+ + ++ ++ ++
Sbjct: 70 EFEIAAKEEKRQRHDVMAHIYTYGLAAPAASGIIHLGATSCFVTDNADLIFLRSAMDLLI 129
Query: 123 KDLKELRSILKELAKKHIDTVCIGRTHGQHAVPTTYGMKFALWLDEIQRHIERLQQLKDR 182
L + + L + + ++ D +G TH Q A TT G + LW+ E+ + + ++
Sbjct: 130 PKLVNVINRLSQWSLRYKDIPTLGFTHYQPAQLTTVGKRATLWIQELLWDLRNFVRARND 189
Query: 183 VLVGKMRGAVGTAASF-----GD--KAFEIEKLVMEDLGLKPA-RITNQIIQRDVYAELM 234
+ ++G GT ASF GD K E++KLV + G +T Q R + +++
Sbjct: 190 IGFRGVKGTTGTQASFLALFEGDHAKVEELDKLVAKLSGFDNVYPVTGQTYDRKIDIDVL 249
Query: 235 FFLALVASTLDKMALEIRNLQRTEILEVSEPFGEKQVGSSTMPHKRNPIRTEKVCGLARV 294
LA +T K+A +IR L + EV EPF Q+GSS M +KRNP+R E++C AR
Sbjct: 250 QPLASFGATAHKIATDIRLL--ANLKEVEEPFEAGQIGSSAMAYKRNPMRCERICSQARY 307
Query: 295 LYSNVIPALLN--NPLWHERDLTNSSVERVILPESFVLLDEMLKVMKKVLKGLEFFPENI 352
+ N+IP LN + W ER L +SS R +LPE+F+ D +LK++ V+ G+ +P+ I
Sbjct: 308 I-MNLIPNALNTASVQWFERTLDDSSNRRSLLPEAFLFTDSVLKILLNVISGMVIYPKVI 366
Query: 353 KRNLYLTKNLIMAEPLMLKLAEKGMGRQEAHELVRQLAMKAFK----EG--RDLLEVVRK 406
++++ + E +++ + + G R E HE +R L+ +A + EG DL+E ++
Sbjct: 367 QKHIRAELPFMATENIIMAMTKHGASRHECHEQIRVLSHQAGRVVKEEGGDNDLIERIKN 426
Query: 407 NEEAMKYLTENDLEGLKPENYIGKAREIVENVVN 440
E D L ++G+A E E+ VN
Sbjct: 427 TPYFAPIYDELD-SLLDASTFVGRAPEQTESFVN 459
>pir||T35016 probable 3-carboxy-cis,cis-muconate cycloisomerase - Streptomyces
coelicolor >gi|5139554|emb|CAB45572.1| (AL079355)
putative 3-carboxy-cis,cis-muconate cycloisomerase
[Streptomyces coelicolor A3(2)]
Length = 454
Score = 162 bits (405), Expect = 9e-39
Identities = 137/422 (32%), Positives = 204/422 (47%), Gaps = 17/422 (4%)
Query: 25 LQKLLDVEAALARAHAKLGNIPEESARVISE-RANTKWVKLERVKEIEAEIHHDIMAVVK 83
L+ LLD EAAL RA A LG P E+A + A+ + E + + ++ +V
Sbjct: 40 LRALLDAEAALTRAQAALGLAPAEAADAVGAVAADPAAFDARSLAERARDGGNPVIPLVA 99
Query: 84 ALSEVCGE-HGKYVHLGATSNDIIDTANALLIKESLAIVEKDLKELRSILKELAKKHIDT 142
L++ GE +G YVH GATS DI+DTA L+ +L ++ DL L LA +H DT
Sbjct: 100 DLTKAVGEPYGPYVHRGATSQDILDTATMLVAARTLDLLLPDLARTERALARLAAEHRDT 159
Query: 143 VCIGRTHGQHAVPTTYGMKFALWLDEIQRHIERLQQLKDRVLVGKMRGAVGTAASF---- 198
GRT QHAVPT +G+K A W + +R+ ++D L ++ GA GT A+F
Sbjct: 160 PMPGRTLTQHAVPTVFGLKAAGWRALVLDARDRITAVRD-ALPAQLGGAAGTLAAFEAYG 218
Query: 199 GDKAFEIEKLVMEDLGLKPARITNQIIQRDVYAELMFFLALVASTLDKMALEIRNLQRTE 258
+ +LGL+ A + R A+L LA A L K+A+++ L RTE
Sbjct: 219 ATDPTALPAAYAGELGLR-APVLPWHTLRTPIADLAGTLAFTAGALGKIAVDVLTLSRTE 277
Query: 259 ILEVSEPFGEKQVGSSTMPHKRNPIRTEKVCGLARVLYSNVIPALLNNPLWHERDLTNSS 318
EV+E G GSS MPHK NP+R+ + AR + ER
Sbjct: 278 TGEVAEGGGG---GSSAMPHKANPVRSTLIAAAARRAPQLAATLYGSLAAEDERPAGAWH 334
Query: 319 VERVILPESFVLLDEMLKVMKKVLKGLEFFPENIKRNLYLTKNLIMAEPLMLKLAEKGMG 378
E L + L + ++ +GL P+ ++ +L T LI++E L +LA +G
Sbjct: 335 AEWEPLRDLLRLTGGAARDAAELAEGLRVRPDAMRAHLGRTHGLIVSERLSAELAPV-LG 393
Query: 379 RQEAHELVRQLAMKAFKEGRDLLEVVRKNEEAMKYLTENDLEG-LKPENYIGKAREIVEN 437
R A EL+ +LA +A+ E R+L E++ + E L DL G P Y G A + +
Sbjct: 394 RARARELLTELAARAYAEDRNLGELLAEVPE----LRGLDLAGPTDPARYTGAAATLTDR 449
Query: 438 VV 439
+
Sbjct: 450 AL 451
>pir||T23969 hypothetical protein R06C7.5 - Caenorhabditis elegans
>gi|3878838|emb|CAA95843.1| (Z71266) Similarity to Human
adenylosuccinate lyase (SW:PUR8_HUMAN), contains
similarity to Pfam domain: PF00206 (Lyase), Score=165.2,
E-value=3.5e-46, N=1~cDNA EST EMBL:Z14522 comes from
this gene~cDNA EST yk67g5.3 comes from this gene~cDNA
EST yk67g5>
Length = 478
Score = 160 bits (401), Expect = 3e-38
Identities = 111/390 (28%), Positives = 200/390 (50%), Gaps = 21/390 (5%)
Query: 18 VWEEENKLQKLLDVEAALARAHAKLGNIPEESARVISERANTKWVKLERVKEIEAEIHHD 77
+ E NK + LA A +LG + ++N ++ E ++ HD
Sbjct: 24 ILSETNKATLWRQLWIWLAEAEKELGLKQVTQDAIDEMKSNRDVFDWPFIRSEERKLKHD 83
Query: 78 IMAVVKALSEVCGEHGKYVHLGATSNDIIDTANALLIKESLAIVEKDLKELRSILKELAK 137
+MA A ++C +HLGATS + D A+ + ++S+ + K + L +
Sbjct: 84 VMAHNHAFGKLCPTAAGIIHLGATSCFVQDNADLIAYRDSIDHILKRFATVIDRLAAFSL 143
Query: 138 KHIDTVCIGRTHGQHAVPTTYGMKFALWLDEIQRHIERLQQLKDRVLVGKMRGAVGTAAS 197
K+ + V +GRTH Q A T G + LW E+ + L + +D++ ++GA GT S
Sbjct: 144 KNKEVVTVGRTHYQTASLVTVGKRGVLWAQELLMAFQSLSEFRDKMRFRGIKGATGTQDS 203
Query: 198 F-----GDKAFEIEKLVMEDLGLKPAR------ITNQIIQRDVYAELMFFLALVASTLDK 246
F GD++ ++E L ++L K A IT Q R ++L+F L+L+ + K
Sbjct: 204 FLTLFAGDES-KVEAL--DELVTKKANFSNRFLITGQTYSRQQDSQLVFSLSLLGAAAKK 260
Query: 247 MALEIRNLQRTEILEVSEPFGEKQVGSSTMPHKRNPIRTEKVCGLARVLYS---NVIPAL 303
+ +IR LQ E+ EPF + Q+GSS MP+K+NP+++E+ C L+R L + + L
Sbjct: 261 VCTDIRVLQ--AFGELLEPFEKDQIGSSAMPYKKNPMKSERCCALSRKLINAPQEALTIL 318
Query: 304 LNNPLWHERDLTNSSVERVILPESFVLLDEMLKVMKKVLKGLEFFPENIKRNLYLTKNLI 363
+ L ER L +S+ R+++P+ + + +L ++ + +GL +N+K+ + +
Sbjct: 319 ADQGL--ERTLDDSAGRRMLIPDVLLTAEALLTTLQNIFEGLSVQTDNVKKIVEDEIAFL 376
Query: 364 MAEPLMLKLAEKGMGRQEAHELVRQLAMKA 393
E M+ L E+G+ RQ+AH ++R+ A++A
Sbjct: 377 GLEKAMMMLTEEGVDRQQAHAVIRKTALEA 406
>pir||D70708 probable purB protein - Mycobacterium tuberculosis (strain H37RV)
>gi|1550655|emb|CAB02389.1| (Z80226) purB [Mycobacterium
tuberculosis]
Length = 472
Score = 150 bits (375), Expect = 3e-35
Identities = 133/458 (29%), Positives = 212/458 (46%), Gaps = 26/458 (5%)
Query: 9 RYGSEEMRRVWEEENKLQKLLDVEAALARAHAKLGNIPEESARVISERANTKWVKLERVK 68
RY S EM +W E K+ + A+ RA A+LG +S ER V L +
Sbjct: 10 RYASAEMVAIWSPEAKVVSERRLWLAVLRAQAELGVAVADSVLADYERVVDD-VDLASIS 68
Query: 69 EIEAEIHHDIMAVVKALSEVCGEHGKYVHLGATSNDIIDTANALLIKESLAIVEKDLKEL 128
E + HD+ A ++ + + G ++VH G TS D+ + L I+ SL ++
Sbjct: 69 ARERVLRHDVKARIEEFNALAGH--EHVHKGMTSRDLTENVEQLQIRRSLEVIFAHGVAA 126
Query: 129 RSILKELAKKHIDTVCIGRTHGQHAVPTTYGMKFALWLDEIQRHIERLQQLKDRVLVGKM 188
+ L E A + D + GR+H A TT G +FA E+ + RL++L DR + +
Sbjct: 127 VARLAERAVSYRDLIMAGRSHNVAAQATTLGKRFASAAQEMMIALRRLRELIDRYPLRGI 186
Query: 189 RGAVGTAASF-----GDKAF--EIEKLVMEDLGLKPA-RITNQIIQRDVYAELMFFLALV 240
+G +GT GD+A ++E+ V + LG Q+ R + +++ L +
Sbjct: 187 KGPMGTGQDMLDLLGGDRAALADLERRVADFLGFATVFNSVGQVYPRSLDHDVVSALVQL 246
Query: 241 ASTLDKMALEIRNLQRTEILEVSEPFGEKQVGSSTMPHKRNPIRTEKVCGLARVL--YSN 298
+ +A IR + E+ +E F QVGSS MPHK N E+V GL VL Y++
Sbjct: 247 GAGPSSLAHTIRLMAGHEL--ATEGFAPGQVGSSAMPHKMNTRSCERVNGLQVVLRGYAS 304
Query: 299 VIPALLNNPLWHERDLTNSSVERVILPESFVLLDEMLKVMKKVLKGLEFFPENIKRNLYL 358
++ A L W+E D+ S V RV LP+SF +D ++ VL +P I R L
Sbjct: 305 MV-AELAGAQWNEGDVFCSVVRRVALPDSFFAVDGQIETFLTVLDEFGAYPAVIGRELDR 363
Query: 359 TKNLIMAEPLMLKLAEKGMGRQEAHELVRQ------LAMKAFKEGRDLLEVVRKNEEAMK 412
+ +++ GMGR+ AH L+ + LAM+ DLL+ R +
Sbjct: 364 YLPFLATTKVLMAAVRAGMGRESAHRLISEHAVATALAMREHGAEPDLLD--RLAADPRL 421
Query: 413 YLTENDLEGLKPEN--YIGKAREIVENVVNYVEEMERR 448
L + LE + + G A + V++VV V+ + R
Sbjct: 422 TLGRDALEAALADKKAFAGAAGDQVDDVVAMVDALVSR 459
>dbj|BAA89447.1| (AB003161) adenylosuccino lyase [Corynebacterium ammoniagenes]
Length = 479
Score = 148 bits (371), Expect = 9e-35
Identities = 132/458 (28%), Positives = 217/458 (46%), Gaps = 31/458 (6%)
Query: 9 RYGSEEMRRVWEEENKLQKLLDVEAALARAHAKLG-NIPEESARVISERANTKWVKLERV 67
RY S E+ +W E+K+ + A+ RA LG +IP E+ + + A V L +
Sbjct: 17 RYASAELSNLWSPEHKIIMERQLWIAVMRAQKDLGVDIPSEA--IDAYEAVIDQVDLGSI 74
Query: 68 KEIEAEIHHDIMAVVKALSEVCGEHGKYVHLGATSNDIIDTANALLIKESLAIV-EKDLK 126
+ E HD+ A ++ + + G +++H G TS D+ + L I SL ++ +K +
Sbjct: 75 ADRERVTRHDVKARIEEFNALAGH--EHIHKGMTSRDLTENVEQLQIYRSLELIRDKAIA 132
Query: 127 ELRSILKELAKKHIDTVCIGRTHGQHAVPTTYGMKFALWLDEIQRHIERLQQLKDRVLVG 186
+ L A K+ V GR+H A TT G +FA DE+ IER++ L R +
Sbjct: 133 VCSAHLVSTAAKYQTLVMAGRSHNVAAQATTLGKRFASAGDEMLLAIERVENLLARYPLR 192
Query: 187 KMRGAVGTAASFGD-------KAFEIEKLVMEDLGLKPARITN---QIIQRDVYAELMFF 236
++G +GT+ D K +E + + LG AR+ N QI R + + +
Sbjct: 193 GIKGPMGTSQDMLDLMGGDENKLAALETDIADHLGF--ARVFNSVGQIYPRTLDFDAVSA 250
Query: 237 LALVASTLDKMALEIRNLQRTEILEVSEPFGEKQVGSSTMPHKRNPIRTEKVCGLARVLY 296
L + ++ +A IR + E V+E F E QVGSS MPHK N E+V GL +L
Sbjct: 251 LVELGASPSSLATTIRLMAGNET--VTEGFKEGQVGSSAMPHKMNARSCERVGGLQVILR 308
Query: 297 SNV-IPALLNNPLWHERDLTNSSVERVILPESFVLLDEMLKVMKKVLKGLEFFPENIKRN 355
+ + A L W+E D+ S V RV LP++F +D + VL FP I R
Sbjct: 309 GYLTMVADLAGQQWNEGDVFCSVVRRVALPDAFFAIDGQFETFLTVLDEFGAFPAMIDRE 368
Query: 356 LYLTKNLIMAEPLMLKLAEKGMGRQEAHELVRQ------LAMKAFKEGRDLLEVVRKNEE 409
L + +++ G+GR+ AHE++++ L M+ +DLLE + +E
Sbjct: 369 LERYLPFLATTRILMAAVRAGVGRETAHEVIKENAVAVALNMRENGGEQDLLERLAADER 428
Query: 410 AMKYLTENDLEGLKPEN--YIGKAREIVENVVNYVEEM 445
+++ LE + +IG A V+ V+ ++E+
Sbjct: 429 LP--MSKEQLEEALADKHAFIGAAESQVDAVLRRIKEL 464
>emb|CAB08409.1| (Z95151) PurB [Mycobacterium leprae]
Length = 487
Score = 146 bits (364), Expect = 6e-34
Identities = 129/455 (28%), Positives = 206/455 (44%), Gaps = 20/455 (4%)
Query: 9 RYGSEEMRRVWEEENKLQKLLDVEAALARAHAKLGNIPEESARVISERANTKWVKLERVK 68
RY S E+ +W E ++ + A+ RA A+L ++P + V L +
Sbjct: 25 RYASAELVAIWSPEARVIAERQLWLAVLRAQAEL-SVPMPVKAIADYERVLGEVDLASIA 83
Query: 69 EIEAEIHHDIMAVVKALSEVCGEHGKYVHLGATSNDIIDTANALLIKESLAIVEKDLKEL 128
E + HD+ A ++ + + G + VH G TS D+ + L I+ SL +V +
Sbjct: 84 ARERVLRHDVKARIEEFNALAGH--EQVHKGMTSRDLTENVEQLQIRRSLELVFCHGVAV 141
Query: 129 RSILKELAKKHIDTVCIGRTHGQHAVPTTYGMKFALWLDEIQRHIERLQQLKDRVLVGKM 188
+ L E A + D V GR+H A TT G +FA E + RL++L DR + +
Sbjct: 142 VARLAECAVSYRDLVMAGRSHNVAAQATTLGKRFASATQETLIALTRLRELIDRYPLRGI 201
Query: 189 RGAVGTAASF-----GDKAF--EIEKLVMEDLGL-KPARITNQIIQRDVYAELMFFLALV 240
+G +GT GD A E+E+ + E LG K Q+ R + +++ L +
Sbjct: 202 KGPMGTGQDMLDLLGGDAAALAELEQRIAEFLGFTKVLASVGQVYPRSLDHDVISALVQL 261
Query: 241 ASTLDKMALEIRNLQRTEILEVSEPFGEKQVGSSTMPHKRNPIRTEKVCGLARVLYSNV- 299
+ +A IR + E+ V+E F QVGSS MPHK N E+V GL VL
Sbjct: 262 GAGSSSLAHTIRLMAGHEL--VTEGFAPGQVGSSAMPHKMNSRSCERVNGLQVVLRGYAA 319
Query: 300 IPALLNNPLWHERDLTNSSVERVILPESFVLLDEMLKVMKKVLKGLEFFPENIKRNLYLT 359
+ A L W+E D+ S V RV LP+SF +D ++ VL +P I+R L
Sbjct: 320 MAAELAGAQWNEGDVFCSVVRRVALPDSFFAIDGQIETFLTVLDEFGAYPAVIRRELDRY 379
Query: 360 KNLIMAEPLMLKLAEKGMGRQEAHELVRQ------LAMKAFKEGRDLLEVVRKNEEAMKY 413
+ +++ GMGR+ AH ++R+ LAM+ DLL+ + +
Sbjct: 380 LPFLATTKVLIAAVRAGMGREAAHHVIREHAVATALAMRECGAEPDLLDRLAADGRLPLD 439
Query: 414 LTENDLEGLKPENYIGKAREIVENVVNYVEEMERR 448
D + + G A + V+ VV V+++ R
Sbjct: 440 RAALDAALADKKAFTGAAADQVDEVVAMVDKLVGR 474
>gb|AAC38245.1| (AF003947) 3-carboxy-cis,cis-muconate cycloisomerase homolog
[Rhodococcus opacus]
Length = 450
Score = 140 bits (349), Expect = 3e-32
Identities = 134/452 (29%), Positives = 211/452 (46%), Gaps = 38/452 (8%)
Query: 7 DYRYGSEEMRRVWEEENKLQKLLDVEAALARAHAKLGNIPEESA--------RVISERAN 58
D +G+ E+ + + + +++VEAALARA AK IP SA RV++E +
Sbjct: 13 DPTFGAGELSALLSDRAWVTAMVEVEAALARAEAKCDVIPAASADAISSVFARVVAEGS- 71
Query: 59 TKWVKLERVKEIEAEIHHDIMAVVKAL-SEVC----GEHGKYVHLGATSNDIIDTANALL 113
V + + E A + ++ +VK L EV G G +VH GATS DI+DTA LL
Sbjct: 72 ---VDVGALGEAAAAGGNPVIPLVKLLRGEVAAADLGVPGSHVHKGATSQDILDTALMLL 128
Query: 114 IKESLAIVEKDLKELRSILKELAKKHIDTVCIGRTHGQHAVPTTYGMKFALWLDEIQRHI 173
+ S A + L E + LA+ DT GRT GQ A+PTT+G+ A W+ + R
Sbjct: 129 CRRSGAHILASLDEAVLCAEALARAQRDTPIAGRTLGQQAIPTTFGVLAAGWMTALHRAS 188
Query: 174 ERLQQLKDRVLVGKMRGAVGTAASFGDKAFEIEKLVMEDLGLKPARITNQIIQRDVYAEL 233
L D + V ++ GA GT+A+ ++ ++ ++LGL + R A L
Sbjct: 189 RALFDALDGLPV-QLGGAAGTSAALHPHGLDVADVLADELGLARQDVPWH-TDRTRIALL 246
Query: 234 MFFLALVASTLDKMALEIRNLQRTEILEVSEPFGEKQVGSSTMPHKRNPIRTEKVCGLAR 293
L A + K+A ++ L TE+ EVSE GSS MPHKRNP+ + A
Sbjct: 247 ASALGTAAGAVSKIATDLVFLSSTEVGEVSE---GSPGGSSAMPHKRNPVAA--IAARAA 301
Query: 294 VLYSNVIPALLNNPLWHERDLTNSS--VERVILPESFVLLDEMLKVMKKVLKGLEFFPEN 351
+ + A + + HE+ + E L + L + + L GL P+
Sbjct: 302 SRRTPGLVATILGSMDHEQQRAAGAWHAEWETLTDLLRLTGGAVARIADSLGGLNVHPDA 361
Query: 352 IKRNLYLTKNLIMAEPLMLKLAEKGMGRQEAHELVRQLAMKAFKEGRDLLEVVRKNEEAM 411
+ RNL +T L++AE + L+ + + R L A + G L E + +
Sbjct: 362 MARNLDITGGLLLAERVTGALSAR-------TDNARDLVTAACETGHPLDE----DPGLL 410
Query: 412 KYLTENDLEG-LKPENYIGKAREIVENVVNYV 442
+YL +++ L P Y+G A +IV+ + V
Sbjct: 411 EYLQVDEIRALLDPAGYLGHAHDIVDRALETV 442
>gb|AAC38208.1| (AF021092) adenylosuccinate lyase [Helicobacter pylori]
Length = 172
Score = 125 bits (310), Expect = 1e-27
Identities = 64/161 (39%), Positives = 94/161 (57%), Gaps = 3/161 (1%)
Query: 9 RYGSEEMRRVWEEENKLQKLLDVEAALARAHAKLGNIPEESARVISERANTKWVKLERVK 68
RY +EEM+ +W E+ K + L+VE A+ RA KLG I + I +A LER+
Sbjct: 4 RYANEEMKALWNEQTKFETYLEVEKAVVRAWNKLGQIQDSDCEKICAKAA---FNLERIT 60
Query: 69 EIEAEIHHDIMAVVKALSEVCGEHGKYVHLGATSNDIIDTANALLIKESLAIVEKDLKEL 128
EIE HD++A ++E GE ++ H G TS+D IDTA ALL+ +SL ++++ + L
Sbjct: 61 EIENHTKHDLIAFTTWVAESLGEESRFFHYGITSSDCIDTAMALLMTKSLTLIQQGVNNL 120
Query: 129 RSILKELAKKHIDTVCIGRTHGQHAVPTTYGMKFALWLDEI 169
LK +H DT+ +GR+HG P T+G+ AL DEI
Sbjct: 121 YETLKNRVSEHTDTLMVGRSHGVFGEPITFGLVLALSADEI 161
>gb|AAD28329.1|AF080446_2 (AF080446) adenylosuccinate lyase [Plasmodium chabaudi adami]
Length = 458
Score = 123 bits (307), Expect = 3e-27
Identities = 117/392 (29%), Positives = 182/392 (45%), Gaps = 32/392 (8%)
Query: 66 RVKEIEAEIHHDIMAVVKALSEVCGEHG-------KYVHLGATSNDIIDTANALLIKESL 118
R+K+IE E +HD+ AV + E ++ +YVH TS DI + A A+ IK L
Sbjct: 76 RLKKIEEETNHDVKAVEYFIKEKINQNNGELVNIKEYVHYLCTSEDINNIAYAICIKSCL 135
Query: 119 A-IVEKDLKELRSILKELAKKHIDTVCIGRTHGQHAVPTTYGMKFALWLDEIQRHIERLQ 177
I+ ++++ + LKELA ++ + RTHGQ A TT+G + A + D ++RHI L+
Sbjct: 136 NNIIIPHIEKIMNRLKELASEYSQVSILSRTHGQPASATTFGKEMANYFDRLKRHISTLK 195
Query: 178 QLKDRVLVGKMRGAVGT------AASFGDKAFEIEKLVMEDLGLKPARITNQIIQRDVYA 231
+K + GK GAVG A S D I+ V + + + QI D
Sbjct: 196 NIK---IYGKFNGAVGNFNAHKIANSNIDWVNNIKYFVEKYFDINYSLYCTQIQDHDYIC 252
Query: 232 ELMFFLALVASTLDKMALEIRNLQRTEILEVSEPFGEKQVGSSTMPHKRNPIRTEKVCG- 290
E+ L + STL ++++I +L++ + ++GSSTMPHK NPI E G
Sbjct: 253 EISDALGRINSTLLDLSIDIWLYISNNLLKLKHV--KNEIGSSTMPHKINPIDFENAEGN 310
Query: 291 --LARVLYSNVIPALLNNPLWHERDLTNSSVERVILPESFVLLDEMLKVMKKVLKGLEFF 348
LA L+ L + L +RDL++S+V R I S+ L K +L+GL
Sbjct: 311 LHLANALFKAFSAKLSISRL--QRDLSDSTVLRNI-GSSYAY---SLIAYKSILRGLTKI 364
Query: 349 PENIKRNLYLTKN--LIMAEPLMLKLAEKGMGRQEAHELVRQLAMKAFKEGRDLLEVVRK 406
N + N +AEP+ + L K A+E ++ + + E ++
Sbjct: 365 DINEQSASQELNNNWSTLAEPVQIVL--KNFNFPNAYEELKNFTRGKTIDKELMQEYIKT 422
Query: 407 NEEAMKYLTENDLEGLKPENYIGKAREIVENV 438
E + N L L P YIG A + NV
Sbjct: 423 KSEFIPPNAMNQLLELTPNTYIGYADYLANNV 454
>pir||F83317 adenylosuccinate lyase PA2629 [imported] - Pseudomonas aeruginosa
(strain PAO1) >gi|9948696|gb|AAG06017.1|AE004691_8
(AE004691) adenylosuccinate lyase [Pseudomonas
aeruginosa]
Length = 456
Score = 122 bits (302), Expect = 1e-26
Identities = 126/458 (27%), Positives = 214/458 (46%), Gaps = 44/458 (9%)
Query: 2 AVHPIDYRYGSE--EMRRVWEEENKLQKLLDVEAALARAHAKLGNIPE-------ESARV 52
AV P+D RY + +R ++ E ++ + VE + A IPE +A +
Sbjct: 8 AVSPVDGRYAGKTSSLRPIFSEYGLIRFRVMVEVRWLQRLAAHAGIPEVAPFSAEANALL 67
Query: 53 ISERANTKWVKLERVKEIEAEIHHDIMAVVKALSEVCGEH------GKYVHLGATSNDII 106
S ++ + ER+KEIE +HD+ AV L E + +++H TS DI
Sbjct: 68 DSLASDFQLEHAERIKEIERTTNHDVKAVEYLLKEQAAKLPELAAVSEFIHFACTSEDIN 127
Query: 107 DTANALLIKESL-AIVEKDLKELRSILKELAKKHIDTVCIGRTHGQHAVPTTYGMKFALW 165
+ ++AL+++E +++ ++++ ++ELA K D + RTHGQ A PTT G + A
Sbjct: 128 NLSHALMLREGRDSVLLPLMRQIAEAIRELAVKLADVPMLSRTHGQPASPTTLGKELANV 187
Query: 166 LDEIQRHIERLQQLKDRVLVGKMRGAVG------TAASFGDKAFEIEKLVMEDLGLKPAR 219
+ ++R I+++ ++ L+GK+ GAVG +A D + + DLGL
Sbjct: 188 VYRLERQIKQVAGIE---LLGKINGAVGNYNAHLSAYPEVDWEANARQFIEGDLGLTFNP 244
Query: 220 ITNQIIQRDVYAELMFFLALVASTLDKMALEIRNLQRTEILEVSEPFGEKQVGSSTMPHK 279
T QI D AEL +A + L ++ + GE +GSSTMPHK
Sbjct: 245 YTTQIEPHDYIAELFDAIARFNTILIDFDRDVWGYISLGYFKQKTVAGE--IGSSTMPHK 302
Query: 280 RNPI---RTEKVCGLARVLYSNVIPALLNNPLWHERDLTNSSVER---VILPESFVLLDE 333
NPI +E G+A L+ + + + L W +RDLT+S+V R V + S + +
Sbjct: 303 VNPIDFENSEGNLGIANALFQH-LASKLPISRW-QRDLTDSTVLRNLGVGIAHSIIAYEA 360
Query: 334 MLKVMKKVLKGLEFFPENIKRNLYLTKNLIMAEPLMLKLAEKGMGRQEAHELVRQLAMKA 393
LK + K LE + I +L ++AEP+ + G+ + +E +++L
Sbjct: 361 SLKGIGK----LELNAQRIAEDLDACWE-VLAEPVQTVMRRYGV--ENPYEKLKELTRGK 413
Query: 394 FKEGRDLLEVVRKNEEAMKYLTENDLEGLKPENYIGKA 431
L + E A+ + +L+ L P Y+G A
Sbjct: 414 GISAEALQTFI--EELAIPAEAKVELKKLTPAGYVGNA 449
>pir||A82237 adenylosuccinate lyase VC1126 [imported] - Vibrio cholerae (group
O1 strain N16961) >gi|9655598|gb|AAF94285.1| (AE004193)
adenylosuccinate lyase [Vibrio cholerae]
Length = 456
Score = 117 bits (290), Expect = 3e-25
Identities = 122/467 (26%), Positives = 222/467 (47%), Gaps = 48/467 (10%)
Query: 2 AVHPIDYRYGSEE--MRRVWEEENKLQKLLDVEAALAR---AHAKLGNIPEESAR----V 52
AV P+D RYGS+ +R ++ E L+ VE + A A++ +P SA +
Sbjct: 8 AVSPVDGRYGSKTIALRSIFSEFGLLKYRTIVEIRWLQKLAATAEIAEVPAFSAEANQFL 67
Query: 53 ISERANTKWVKLERVKEIEAEIHHDIMAVVKALSEVCGEH------GKYVHLGATSNDII 106
+ AN R+KEIE +HD+ AV L E +++H TS DI
Sbjct: 68 DAIAANFNEADALRIKEIERTTNHDVKAVEYFLKEKVAAMPELHAVNEFIHFACTSEDIN 127
Query: 107 DTANALLIKESL-AIVEKDLKELRSILKELAKKHIDTVCIGRTHGQHAVPTTYGMKFALW 165
+T++AL++KE+ ++ +++ + +++LA+++ D + RTHGQ A P+T G + A
Sbjct: 128 NTSHALMLKEARDTVILPEIRNVIDAIRKLAEEYRDIPLLSRTHGQPASPSTMGKEMANV 187
Query: 166 LDEIQRHIERLQQLKDRVLVGKMRGAVG------TAASFGDKAFEIEKLVMEDLGLKPAR 219
++R +++ ++ ++ K+ GAVG +A D E+ + E LG+
Sbjct: 188 AYRMERQYKQIANVE---ILAKINGAVGNYNAHLSAYPTVDWHKFSEEFITESLGVDWNP 244
Query: 220 ITNQIIQRDVYAELMFFLALVASTLDKMALEIRNLQRTEILEVSEPFGEKQVGSSTMPHK 279
T QI D AEL +A + L ++ + GE +GSSTMPHK
Sbjct: 245 YTTQIEPHDYIAELFEAVARFNTILIDFDRDVWGYIALGHFKQRTIAGE--IGSSTMPHK 302
Query: 280 RNPI---RTEKVCGLARVLYSNVIPALLNNPL--WHERDLTNSSVER---VILPESFVLL 331
NPI +E GLA +++++ L P+ W +RDLT+S+V R V + + +
Sbjct: 303 VNPIDFENSEGNLGLANAVFTHLAQKL---PISRW-QRDLTDSTVLRNLGVGVGYAIIAY 358
Query: 332 DEMLKVMKKVLKGLEFFPENIKRNLYLTKNLIMAEPLMLKLAEKGMGRQEAHELVRQLAM 391
LK + K+ + + N ++AEP+ + G+ ++ +E +++L
Sbjct: 359 TSTLKGISKLEVNRDALLAELDHNWE-----VLAEPIQTVMRRYGI--EKPYEKLKELTR 411
Query: 392 KAFKEGRDLLEVVRKNEEAMKYLTENDLEGLKPENYIGKAREIVENV 438
+G + + + + A+ + L+ + P +YIG A E+ + +
Sbjct: 412 GKRVDGEAMRQFI--DGLALPAEEKTRLKAMTPASYIGYAIELTDKL 456
>gb|AAA92731.1| (M74924) adenylosuccinate lyase [Escherichia coli]
Length = 456
Score = 115 bits (286), Expect = 8e-25
Identities = 127/473 (26%), Positives = 220/473 (45%), Gaps = 61/473 (12%)
Query: 2 AVHPIDYRYGSE--EMRRVWEEENKLQKLLDVEAALAR---AHAKLGNIPEESARVISER 56
AV P+D RYG + +R ++ E L+ + VE + AHA + +P +A I
Sbjct: 8 AVSPVDGRYGDKVSALRGIFSEYGLLKFRVQVEVRWLQKLAAHAAIKEVPAFAADAIGYL 67
Query: 57 ----ANTKWVKLERVKEIEAEIHHDIMAVVKALSEVCGEH------GKYVHLGATSNDII 106
A+ R+K IE +HD+ AV L E E +++H TS DI
Sbjct: 68 DAIVASFSEEDAARIKTIERTTNHDVKAVEYFLKEKVAEIPELHAVSEFIHFACTSEDIN 127
Query: 107 DTANALLIKESL-AIVEKDLKELRSILKELAKKHIDTVCIGRTHGQHAVPTTYGMKFALW 165
+ ++AL++K + ++ ++L LK+LA ++ D + RTHGQ A P+T G + A
Sbjct: 128 NLSHALMLKTARDEVILAYWRQLIDGLKDLAVQYRDIPLLSRTHGQPATPSTIGKEMANV 187
Query: 166 LDEIQRHIERLQQLKDRVLVGKMRGAVGT----AASFGDKAF-EIEKLVMEDLGLKPARI 220
++R +L Q++ ++GK+ GAVG A++ + + + + + LG++
Sbjct: 188 AYRMERQYRQLNQVE---ILGKINGAVGNYNAHIAAYPEVDWHQFSEEFVTSLGIQWNPY 244
Query: 221 TNQIIQRDVYAELMFFLALVASTLDKMALEIRNLQRTEILEVSEPFGEKQVGSSTMPHKR 280
T QI D AEL +A + L ++ + GE +GSSTMPHK
Sbjct: 245 TTQIEPHDYIAELFDCVARFNTILIDFDRDVWGYIALNHFKQKTIAGE--IGSSTMPHKV 302
Query: 281 NPI---RTEKVCGLARVLYSNVIPALLNNPLWHERDLTNSSVER---VILPESFVLLDEM 334
NPI +E GL+ + + + + L W +RDLT+S+V R V + + +
Sbjct: 303 NPIDFENSEGNLGLSNAVLQH-LASKLPVSRW-QRDLTDSTVLRNLGVGIGYALIAYQST 360
Query: 335 LKVMKKVLKGLEFFPENIKRNLYLTKNLIMAEPLMLKLAEKGMGRQEAHELVRQL----- 389
LK + K+ + + + N ++AEP+ + G+ ++ +E +++L
Sbjct: 361 LKGVSKLEVNRDHLLDELDHNWE-----VLAEPIQTVMRRYGI--EKPYEKLKELTRGKR 413
Query: 390 ----AMKAFKEGRDLLEVVRKNEEAMKYLTENDLEGLKPENYIGKAREIVENV 438
MK F +G L E EE + L+ + P NYIG+A +V+ +
Sbjct: 414 VDAEGMKQFIDGLALPE-----EEKAR------LKAMTPANYIGRAITMVDEL 455
>sp|P25739|PUR8_ECOLI ADENYLOSUCCINATE LYASE (ADENYLOSUCCINASE) (ASL)
>gi|95645|pir||S19212 adenylosuccinate lyase (EC
4.3.2.2) - Escherichia coli >gi|42585|emb|CAA41996.1|
(X59307) adenylosuccinate lyase [Escherichia coli]
>gi|1651559|dbj|BAA35953.1| (D90748) Adenylosuccinate
lyase (EC 4.3.2.2) [Escherichia coli]
>gi|1651565|dbj|BAA35962.1| (D90749) Adenylosuccinate
lyase (EC 4.3.2.2) [Escherichia coli]
>gi|1787376|gb|AAC74215.1| (AE000213) adenylosuccinate
lyase [Escherichia coli K12]
Length = 456
Score = 115 bits (284), Expect = 1e-24
Identities = 126/473 (26%), Positives = 220/473 (45%), Gaps = 61/473 (12%)
Query: 2 AVHPIDYRYGSE--EMRRVWEEENKLQKLLDVEAALAR---AHAKLGNIPEESARVISER 56
AV P+D RYG + +R ++ E L+ + VE + AHA + +P +A I
Sbjct: 8 AVSPVDGRYGDKVSALRGIFSEYGLLKFRVQVEVRWLQKLAAHAAIKEVPAFAADAIGYL 67
Query: 57 ----ANTKWVKLERVKEIEAEIHHDIMAVVKALSEVCGEH------GKYVHLGATSNDII 106
A+ R+K IE +HD+ AV L E E +++H TS DI
Sbjct: 68 DAIVASFSEEDAARIKTIERTTNHDVKAVEYFLKEKVAEIPELHAVSEFIHFACTSEDIN 127
Query: 107 DTANALLIKESL-AIVEKDLKELRSILKELAKKHIDTVCIGRTHGQHAVPTTYGMKFALW 165
+ ++AL++K + ++ ++L +K+LA ++ D + RTHGQ A P+T G + A
Sbjct: 128 NLSHALMLKTARDEVILPYWRQLIDGIKDLAVQYRDIPLLSRTHGQPATPSTIGKEMANV 187
Query: 166 LDEIQRHIERLQQLKDRVLVGKMRGAVGT----AASFGDKAF-EIEKLVMEDLGLKPARI 220
++R +L Q++ ++GK+ GAVG A++ + + + + + LG++
Sbjct: 188 AYRMERQYRQLNQVE---ILGKINGAVGNYNAHIAAYPEVDWHQFSEEFVTSLGIQWNPY 244
Query: 221 TNQIIQRDVYAELMFFLALVASTLDKMALEIRNLQRTEILEVSEPFGEKQVGSSTMPHKR 280
T QI D AEL +A + L ++ + GE +GSSTMPHK
Sbjct: 245 TTQIEPHDYIAELFDCVARFNTILIDFDRDVWGYIALNHFKQKTIAGE--IGSSTMPHKV 302
Query: 281 NPI---RTEKVCGLARVLYSNVIPALLNNPLWHERDLTNSSVER---VILPESFVLLDEM 334
NPI +E GL+ + + + + L W +RDLT+S+V R V + + +
Sbjct: 303 NPIDFENSEGNLGLSNAVLQH-LASKLPVSRW-QRDLTDSTVLRNLGVGIGYALIAYQST 360
Query: 335 LKVMKKVLKGLEFFPENIKRNLYLTKNLIMAEPLMLKLAEKGMGRQEAHELVRQL----- 389
LK + K+ + + + N ++AEP+ + G+ ++ +E +++L
Sbjct: 361 LKGVSKLEVNRDHLLDELDHNWE-----VLAEPIQTVMRRYGI--EKPYEKLKELTRGKR 413
Query: 390 ----AMKAFKEGRDLLEVVRKNEEAMKYLTENDLEGLKPENYIGKAREIVENV 438
MK F +G L E EE + L+ + P NYIG+A +V+ +
Sbjct: 414 VDAEGMKQFIDGLALPE-----EEKAR------LKAMTPANYIGRAITMVDEL 455
>emb|CAB99134.1| (AL390188) putative adenylosuccino lyase (fragment) [Streptomyces
coelicolor A3(2)]
Length = 362
Score = 113 bits (280), Expect = 4e-24
Identities = 103/354 (29%), Positives = 173/354 (48%), Gaps = 24/354 (6%)
Query: 114 IKESLAIVEKDLKELRSILKELAKKHIDTVCIGRTHGQHAVPTTYGMKFALWLDEIQRHI 173
I+ SL +V + + L +LA ++ + V GR+H A TT G +FA DE+
Sbjct: 1 IRLSLELVRDRSVAVLARLGKLAGEYGELVMAGRSHNVAAQATTLGKRFASAADELLVAY 60
Query: 174 ERLQQLKDRVLVGKMRGAVGTAASFGD-------KAFEIEKLVMEDLGLKPARIT-NQII 225
R+++L R + ++G VGTA D K ++E+ + LG A + Q+
Sbjct: 61 GRVEELLGRYPLRGIKGPVGTAQDMLDLLGGDAGKLADLEQRIAGHLGFSQAFTSVGQVY 120
Query: 226 QRDVYAELMFFLALVASTLDKMALEIRNLQRTEILEVSEPFGEKQVGSSTMPHKRNPIRT 285
R + E++ L +A+ +A IR + E+ V+E F QVGSS MPHK N
Sbjct: 121 PRSLDYEVVTALVQLAAAPSSLAKTIRLMAGHEL--VTEGFKPGQVGSSAMPHKMNTRSC 178
Query: 286 EKVCGLARVL--YSNVIPALLNNPLWHERDLTNSSVERVILPESFVLLDEMLKVMKKVLK 343
E+V GL +L Y+++ L + W+E D++ S V RV LP++F LD +L+ VL
Sbjct: 179 ERVNGLTVILRGYASMTGELAGDQ-WNEGDVSCSVVRRVALPDAFFALDGLLETFLTVLD 237
Query: 344 GLEFFPENIKRNLYLTKNLIMAEPLMLKLAEKGMGRQEAHELVRQ------LAMK-AFKE 396
FP + R L + +++ G+GR+ AHE +++ LAM+ E
Sbjct: 238 EFGAFPAVVARELDRYLPFLATTKVLMGAVRGGVGREVAHEAIKENAVASALAMREQGAE 297
Query: 397 GRDLLEVVRKNEEAMKYLTENDLEGLKPE--NYIGKAREIVENVVNYVEEMERR 448
+LL+ + ++ L L+ L + ++ G A + V VV +E++ +R
Sbjct: 298 RNELLDKLAADDRIP--LDRAALDALMADKLSFTGAAADQVGVVVGRIEDIVKR 349
>gb|AAG18966.1| (AE004997) adenylosuccinate lyase; PurB [Halobacterium sp. NRC-1]
Length = 495
Score = 108 bits (267), Expect = 1e-22
Identities = 126/469 (26%), Positives = 203/469 (42%), Gaps = 53/469 (11%)
Query: 2 AVHPIDYRYG--SEEMRRVWEEENKLQKLLDVEAALARAHAKLGNIP-----EESARVIS 54
AV P+D RY ++ + E ++ ++VEA A A L +P +E +
Sbjct: 46 AVSPLDGRYSGRTDALAPYVSEAALMRARVEVEAEYVLALADLDAVPLELVGDERTALRD 105
Query: 55 ERANTKWVKLERVKEIEAE-------IHHDIMAVVKALSEVCGEHG-KYVHLGATSNDII 106
+ VK IE E +HD+ AV L E ++H G TS D+
Sbjct: 106 AYKTFDAADADLVKRIETEGALGHAATNHDVKAVEYFLREHAPARAHSWIHFGLTSEDVN 165
Query: 107 DTANALLIKESL-AIVEKDLKELRSILKELAKKHIDTVCIGRTHGQHAVPTTYGMKFALW 165
+ A LL+ ++ A++ +L+ LR L A + D + RTHGQ A PTT+G + A++
Sbjct: 166 NLAYRLLVDGAITAVLTPELRGLRDDLVSFAHDYADLPMLARTHGQPATPTTFGKEMAVY 225
Query: 166 LDEIQRHIERLQQLKDRVLVGKMRGAVGT----AASFGDKAF-EIEKLVMEDLGLKPARI 220
+ R + R+ D L GK+ GA GT A+F D + ++ LGL A
Sbjct: 226 AARLGRALARITDAVDG-LTGKLAGASGTWAAHTAAFPDVDWRSFAARFVDSLGLAYAEP 284
Query: 221 TNQIIQRDVYAELMFFLALVASTLDKMALEIRNLQRTEILEVSEPFGEKQVGSSTMPHKR 280
T Q+ D + +A L+ +A++ L GE GSSTMPHK
Sbjct: 285 TTQVNPCDDLTAVFDAVAGANGVLEDLAVDAWLYVSQRYLGQDAADGE--TGSSTMPHKV 342
Query: 281 NPIRTEKVCGLARVLYSNVIPALLNNPLWH---ERDLTNSSVERVILPESFVLLDEMLKV 337
NPI E G + +N L + L +RDL++S+V+R I L
Sbjct: 343 NPIDFENAEG--NLAKANSDLGFLGDSLTTSRLQRDLSDSTVKRNI----GAAFAHCLLA 396
Query: 338 MKKVLKGLEFFPENIKRNLYLTKNLIMAEPLMLKLAEKGMGRQEAHELVRQLAMKAFKEG 397
+K+ GL + + N + + + A P ++ A + + R+E H+ A++
Sbjct: 397 YRKLGDGL----DAVTPNEAVLREDLRANPEVIGEAVQTILRREGHD-------DAYERV 445
Query: 398 RDLLEVVRKNEEAMKYL---------TENDLEGLKPENYIGKAREIVEN 437
+ L R + + K L T ++L L PE Y+G A +I +
Sbjct: 446 KALTRGERVSLDDFKELFASLDIDADTRDELLALTPERYVGVAADIARD 494
>pir||A43307 adenylosuccinate lyase - Escherichia coli
Length = 435
Score = 107 bits (264), Expect = 3e-22
Identities = 119/441 (26%), Positives = 204/441 (45%), Gaps = 45/441 (10%)
Query: 2 AVHPIDYRYGSE--EMRRVWEEENKLQKLLDVEAALAR---AHAKLGNIPEESARVISER 56
AV P+D RYG + +R ++ E L+ + VE + AHA + +P +A I
Sbjct: 8 AVSPVDGRYGDKVSALRGIFSEYGLLKFRVQVEVRWLQKLAAHAAIKEVPAFAADAIGYL 67
Query: 57 ----ANTKWVKLERVKEIEAEIHHDIMAVVKALSEVCGEH------GKYVHLGATSNDII 106
A+ R+K IE +HD+ AV L E E +++H TS DI
Sbjct: 68 DAIVASFSEEDAARIKTIERTTNHDVKAVEYFLKEKVAEIPELHAVSEFIHFACTSEDIN 127
Query: 107 DTANALLIKESL-AIVEKDLKELRSILKELAKKHIDTVCIGRTHGQHAVPTTYGMKFALW 165
+ ++AL++K + ++ ++L LK+LA ++ D + RTHGQ A P+T G + A
Sbjct: 128 NLSHALMLKTARDEVILAYWRQLIDGLKDLAVQYRDIPLLSRTHGQPATPSTIGKEMANV 187
Query: 166 LDEIQRHIERLQQLKDRVLVGKMRGAVGT----AASFGDKAF-EIEKLVMEDLGLKPARI 220
++R +L Q++ ++GK+ GAVG A++ + + + + + LG++
Sbjct: 188 AYRMERQYRQLNQVE---ILGKINGAVGNYNAHIAAYPEVDWHQFSEEFVTSLGIQWNPY 244
Query: 221 TNQIIQRDVYAELMFFLALVASTLDKMALEIRNLQRTEILEVSEPFGEKQVGSSTMPHKR 280
T QI D AEL +A + L ++ + GE +GSSTMPHK
Sbjct: 245 TTQIEPHDYIAELFDSVARFNTILIDFDRDVWGYIALNHFKQKTIAGE--IGSSTMPHKV 302
Query: 281 NPIRTEKVCGLARVLYSNVIPALLNNPL----WHERDLTNSSVER---VILPESFVLLDE 333
NPI E G + SN + L + L W +RDLT+S+V R V + + +
Sbjct: 303 NPIDFENSEG--NLGLSNAVLQTLASKLPVSRW-QRDLTDSTVLRNLGVGIGYALIAYQS 359
Query: 334 MLKVMKKVLKGLEFFPENIKRNLYLTKNLIMAEPLMLKLAEKGMGR--QEAHELVR--QL 389
LK + K+ + + + N ++AEP+ + G+ + ++ EL R ++
Sbjct: 360 TLKGVSKLEVNRDHLLDELDHNWE-----VLAEPIQTVMRRYGIEKPYEKLKELTRGKRV 414
Query: 390 AMKAFKEGRDLLEVVRKNEEA 410
+ K+ D L +K + A
Sbjct: 415 DAEGMKQFIDGLRCQKKRKPA 435
>gb|AAF34266.1| (U32867) 3-carboxy-cis,cis-muconate cycloisomerase [Agrobacterium
tumefaciens]
Length = 353
Score = 106 bits (263), Expect = 4e-22
Identities = 91/335 (27%), Positives = 153/335 (45%), Gaps = 11/335 (3%)
Query: 10 YGSEEMRRVWEEENKLQKLLDVEAALARAHAKLGNIPEESARVISERANTKWVKLERVKE 69
+G E+ ++ + ++ E ALA+A G I E+ A+ I + + ++
Sbjct: 15 FGDSEIVELFSARADIDAMIRFETALAQAQVGTGIISEDVAKAIVSGLSEFAADMTALRH 74
Query: 70 IEAEIHHDIMAVVKAL-SEVCGEHGKYVHLGATSNDIIDTANALLIKESLAIVEKDLKEL 128
A+ + +V+ + + V G+ + VH GATS D+IDT+ L +K + I+ L L
Sbjct: 75 GVAKDGVVVPELVRQMRAAVAGKAAEKVHFGATSQDVIDTSLMLRLKMATEIIAARLGRL 134
Query: 129 RSILKELAKKHIDTVCIGRTHGQHAVPTTYGMKFALWLDEIQRHIERLQQLKDRVLVGKM 188
L ++A + G T Q A+ T + A W+ ++RH+ RL+ +
Sbjct: 135 IDALGDIAARDGHNALTGYTRMQAAIGITVADRAASWIAPLERHLLRLETFAQSGFALQF 194
Query: 189 RGAVGTAASFGDKAFEIEKLVMEDLGLKPARITNQIIQRDVYAELMFFLALVASTLDKMA 248
GA GT GD A + + LGL + QRD AE L+LV TL K
Sbjct: 195 GGAAGTLEKLGDNAGAVRADLAMRLGLADKQQWQS--QRDGIAEFGNILSLVTGTLGKFG 252
Query: 249 LEIRNLQRTEILEVSEPFGEKQVGSSTMPHKRNPIRTEKVCGLARVLYSNVIPALLNNPL 308
+I L E+ G GSS MPHK+NP+ E + LAR ++ V + L+ L
Sbjct: 253 QDIA-LMAEIGTEIRLSGGG---GSSAMPHKQNPVNAETLAALAR--FNAVQISALHQSL 306
Query: 309 WHERDLTNSS--VERVILPESFVLLDEMLKVMKKV 341
HE++ + + +E + LP+ L + +++
Sbjct: 307 VHEQERSGAGWMLEWLSLPQMVTATGASLLIAERL 341
>sp|O26369|ARLY_METTH ARGININOSUCCINATE LYASE (ARGINOSUCCINASE) (ASAL)
>gi|7437148|pir||H69133 argininosuccinate lyase -
Methanobacterium thermoautotrophicum (strain Delta H)
>gi|2621319|gb|AAB84775.1| (AE000812) argininosuccinate
lyase [Methanobacterium thermoautotrophicum]
Length = 468
Score = 105 bits (259), Expect = 1e-21
Identities = 117/430 (27%), Positives = 193/430 (44%), Gaps = 45/430 (10%)
Query: 30 DVEAALA--RAHAKLGNIPEE-SARVISERANTKWVKLERVKEIEAEIHHDIMAVVKALS 86
D+E +A R A G IPEE +A++I + + +E + +++ + MAV ++
Sbjct: 33 DIECNMAHTRMLAHEGIIPEEVAAKIIDALESLREEGIEAL-DMDPSVEDIHMAVENYVT 91
Query: 87 EVCGEHGKYVHLGATSNDIIDTANALLIKESLAIVEKDLKELRSILKELAKKHIDTVCIG 146
GE ++H G + ND + T L ++E + + ++L + + +LA H +TV +G
Sbjct: 92 ARIGEEAGFMHTGKSRNDQVATDLRLALRERIRTISRELLDFIDSISDLALDHTETVMVG 151
Query: 147 RTHGQHAVPTTYGMKFALWLDEIQRHIERLQQLKDRVLVGKMRGAVGTAASFGDKAFEIE 206
TH QHA PTT G + ++R ERLQ RV + A T SF
Sbjct: 152 YTHLQHAQPTTLGHHLMAYASSLRRDYERLQDTLKRVDQNPLGSAAMTTTSFPIN----R 207
Query: 207 KLVMEDLGLKP--ARITNQIIQRDVYAELMFFLALVASTLDKMALE--IRNLQRTEILEV 262
+L LG + + RD AE +F L+++A L +++ E + + I+E+
Sbjct: 208 ELTTRLLGFSDYMKNSMDAVSARDFIAETVFDLSMLAVNLSRISEEMILWSTHEFGIVEI 267
Query: 263 SEPFGEKQVGSSTMPHKRNPIRTEKVCGLARVLYSNVIPALLN-------NPLWHERDLT 315
+ F SS MP K+NP V +AR S V L+ P + RDL
Sbjct: 268 PDEFSST---SSIMPQKKNP----DVAEIARAKTSTVQGELVTILGIMKALPYTYNRDL- 319
Query: 316 NSSVERVILPESFVLLDEMLKVMKKVLKGLEFFPENIKRNLYLT-KNLIMAEPLM-LKLA 373
+ + P + +D +L +++ V L N R L L N A L + +
Sbjct: 320 -----QEVTPHLWRAVDTVLSMIRVVRGMLLGIRVNRNRALELAGANFATATDLADIIVR 374
Query: 374 EKGMGRQEAHELVRQLAMKAFKEGRDLLEVVRKNEEAMKYLTENDLE--GLKPE---NYI 428
E+G+ + AH +V +L +A ++G + + YL E LE G K E +
Sbjct: 375 ERGIPFRVAHRIVGRLVTRAIEDG------LAPGDVDSVYLDEVSLEVTGRKLELDPELV 428
Query: 429 GKAREIVENV 438
KA + +ENV
Sbjct: 429 EKALDPLENV 438
>pir||F71618 adenylosuccinate lyase (OO) PFB0295w - malaria parasite
(Plasmodium falciparum) >gi|3452235|gb|AAC32788.1|
(AF033037) adenylosuccinate lyase; ASL [Plasmodium
falciparum] >gi|3845146|gb|AAC71848.1| (AE001385)
adenylosuccinate lyase (OO) [Plasmodium falciparum]
Length = 471
Score = 102 bits (251), Expect = 1e-20
Identities = 100/400 (25%), Positives = 185/400 (46%), Gaps = 35/400 (8%)
Query: 66 RVKEIEAEIHHDIMAVVKALSEVCGEHGK--------YVHLGATSNDIIDTANALLIKES 117
RVK+IE E +HD+ AV + E YVH TS DI + A L +
Sbjct: 81 RVKKIEEETNHDVKAVEYFIREKLESLKNEEITKVIPYVHYLCTSEDINNIAYGLCLYNC 140
Query: 118 LA-IVEKDLKELRSILKELAKKHIDTVCIGRTHGQHAVPTTYGMKFALWLDEIQRHIERL 176
+ I+ +++ + LKE + + D + +THGQ A PTT+G + + + + +HI +L
Sbjct: 141 IHNIIIPNIQNIIDKLKEFSFNYSDVSLLSKTHGQPASPTTFGKEMSNYYYRLYKHINKL 200
Query: 177 QQLKDRVLVGKMRGAVGTAASFG------DKAFEIEKLVMEDLGLKPARITNQIIQRDVY 230
+ ++ V K GAVG + D I+ + L + QI D
Sbjct: 201 KNIEIYV---KFNGAVGNFNAHKVCDPNIDWIDNIKYFIETYFNLHFSLYCTQIQDHDYI 257
Query: 231 AELMFFLALVASTLDKMALEIRNLQRTEILEVSEPFGEKQVGSSTMPHKRNPIRTEKVCG 290
E+ LA + TL +++++ + +L++ +K++GSSTMPHK NPI E G
Sbjct: 258 CEISDTLARLNYTLIDLSVDMWLYISSNVLKLK--VIQKEIGSSTMPHKVNPIDFENAEG 315
Query: 291 ---LARVLYSNVIPALLNNPLWHERDLTNSSVERVI---LPESFVLLDEMLKVMKKVLKG 344
LA L+ L + L +RDL++S+V R + S + +L+ + K+
Sbjct: 316 NLHLANSLFKLFSSKLPISRL--QRDLSDSTVLRNLGSSFAYSLISYKSLLRGLNKIDVD 373
Query: 345 LEFFPENIKRNLYLTKNLIMAEPLMLKLAEKGMGRQEAHELVRQLAMKAFKEGRDLLEVV 404
E + +N +AEP+ + + + + +++E ++ + + + + +
Sbjct: 374 QNVMNEQLNQNW-----CTLAEPIQIIMKKYNIA--DSYEQLKNFTRGKSIDKQCMYQFI 426
Query: 405 RKNEEAMKYLTENDLEGLKPENYIGKAREIVENVVNYVEE 444
++N + ++L L P NY+G A + +NV ++ +E
Sbjct: 427 QQNCSHLPKNAIDELMNLTPHNYLGYASYLSKNVEHFSQE 466
>pir||D81216 adenylosuccinate lyase NMB0284 [imported] - Neisseria meningitidis
(group B strain MD58) >gi|7225509|gb|AAF40737.1|
(AE002385) adenylosuccinate lyase [Neisseria
meningitidis MC58]
Length = 456
Score = 101 bits (250), Expect = 1e-20
Identities = 131/469 (27%), Positives = 208/469 (43%), Gaps = 51/469 (10%)
Query: 2 AVHPIDYRYGS--EEMRRVWEEENKLQKLLDVEAALARAHA---KLGNIPEESARVISER 56
++ P+D RY E +R ++ E ++ + VE +A A K+ +P SA ++E
Sbjct: 7 SLSPLDGRYAQSVEALRPIFSEYGLMKARVKVELNWLKALAAEPKIAEVPPFSAETLAEI 66
Query: 57 ----ANTKWVKLERVKEIEAEIHHDIMAVV----KALSEV--CGEHGKYVHLGATSNDII 106
N VK IEA +HD+ A+ K +EV +++H TS DI
Sbjct: 67 DTVIENFSLEDAAAVKAIEATTNHDVKAIEYWLKKRFAEVPEVAAVSEFIHFACTSEDIN 126
Query: 107 DTANALLIKESL-AIVEKDLKELRSILKELAKKHIDTVCIGRTHGQHAVPTTYGMKFALW 165
+ ++AL+++E+ A++ L E+ L +A + RTHGQ A PTT G + A
Sbjct: 127 NLSHALMLQEAREAVLLPKLAEIIEKLTAMAHDLAAVPMMSRTHGQPATPTTLGKETANV 186
Query: 166 LDEIQRHIERLQQLKDRVLVGKMRGAVGT----AASFGDKAFE--IEKLVMEDLGLKPAR 219
+ +QR + LQ + +GK+ GAVG ++ D +E V LGL
Sbjct: 187 VYRLQRQFKNLQA---QEFLGKINGAVGNYNAHMVAYPDVDWETHCRNFVEISLGLTFNP 243
Query: 220 ITNQIIQRDVYAELMFFLALVASTLDKMALEIRNLQRTEILEVSEPFGEKQVGSSTMPHK 279
T QI D AE L+ + + L ++ + GE VGSSTMPHK
Sbjct: 244 YTIQIEPHDYMAEFFQTLSRINTILIDFNRDVWGYISLGYFKQKVKAGE--VGSSTMPHK 301
Query: 280 RNPIRTEKVCGLARVLYSNVIPALLNNPL----WHERDLTNSSVERVI-LPESFVLLDEM 334
NPI E G + +N + L+ L W +RDLT+S+V R + + + +L
Sbjct: 302 VNPIDFENSEG--NLGMANAVLGFLSEKLPISRW-QRDLTDSTVLRNMGVGVGYAVLG-- 356
Query: 335 LKVMKKVLKGLEFFPENIKRNLYLTKNLIMAEPLMLKLAEKGMGR--QEAHELVR---QL 389
+ L LE P + +L T L +AEP+ + G+ ++ +L R +
Sbjct: 357 FAAHLRGLNKLEPNPAALAADLDATWEL-LAEPIQTVMRRYGVANPYEKLKDLTRGKGGI 415
Query: 390 AMKAFKEGRDLLEVVRKNEEAMKYLTENDLEGLKPENYIGKAREIVENV 438
+ K LLE+ EA L E L P Y+GKA + + +
Sbjct: 416 TPEVLKGFIGLLEI---PAEAKAKLLE-----LTPALYVGKAEALAKRI 456
>pir||C81930 probable argininosuccinate lyase (EC 4.3.2.1) NMA0847 [imported] -
Neisseria meningitidis (group A strain Z2491)
>gi|7379563|emb|CAB84128.1| (AL162754) putative
argininosuccinate lyase [Neisseria meningitidis Z2491]
Length = 458
Score = 101 bits (250), Expect = 1e-20
Identities = 106/418 (25%), Positives = 197/418 (46%), Gaps = 45/418 (10%)
Query: 30 DVEAALARAH----------AKLGNIPEESARVISERANTKWVKLERVKEIEAEIHHDIM 79
D++ +LA A L +I A ++ E + K +E ++E ++H M
Sbjct: 35 DIQGSLAHAQMLKETGVLDEGDLADIRRGMAEILEEIRSGK---IEWSSDLE-DVH---M 87
Query: 80 AVVKALSEVCGEHGKYVHLGATSNDIIDTANALLIKESLAIVEKDLKELRSILKELAKKH 139
+ + L++ G+ GK +H G + ND + T L +++ + +++ ++ L++ L +LA+++
Sbjct: 88 NIERRLTDKIGDAGKRLHTGRSRNDQVATDIRLWLRDQITVIQSLIQSLQTALLDLAEQN 147
Query: 140 IDTVCIGRTHGQHAVPTTYGMKFALWLDEIQRHIERLQQLKDRVLVGKMRGAVGTAASFG 199
+TV G TH Q A P ++G +++ + R ER+ + RV R +G AA G
Sbjct: 148 AETVMPGFTHLQVAQPVSFGHHMLAYVEMLGRDNERMADCRRRV----NRMPLGAAALAG 203
Query: 200 DKAFEIEKLVMEDLGLKP--ARITNQIIQRDVYAELMFFLALVASTLDKMALEIRNLQRT 257
++ E LG + + + RD E +L+ L +++ E+
Sbjct: 204 TTYPIRREITAELLGFEQICQNSLDAVSDRDFAVEFTAAASLIMVHLSRLSEEL------ 257
Query: 258 EILEVSEPFGEKQV------GSSTMPHKRNPIRTEKVCGLA-RVL--YSNVIPALLNNPL 308
IL +S FG + GSS MP K+NP E V G + RV+ +I + + PL
Sbjct: 258 -ILWMSPRFGFIDIADRFCTGSSIMPQKKNPDVPELVRGKSGRVIGHLIGLITLMKSQPL 316
Query: 309 WHERDLTNSSVERVILPESFVLLDEMLKVMKKVLKGLEFFPENIKRNLYLTKNLIMAEPL 368
+ +D N + + + L+D L++ +++G+ P+N++ + + A L
Sbjct: 317 AYNKD--NQEDKEPLFDTADTLID-TLRIYADMMRGVTVKPDNMR--AAVMQGFATATDL 371
Query: 369 MLKLAEKGMGRQEAHELVRQLAMKAFKEGRDLLEVVRKNEEAMKYLTENDLEG-LKPE 425
L +KGM ++AHE+V Q A + G DL E+ + + L +D+ G L PE
Sbjct: 372 ADYLVKKGMPFRDAHEVVAQAVRHADEAGVDLSELPLEVLQGFSDLIADDVYGVLTPE 429
>pir||B81175 argininosuccinate lyase NMB0637 [imported] - Neisseria meningitidis
(group B strain MD58) >gi|7225866|gb|AAF41060.1|
(AE002419) argininosuccinate lyase [Neisseria
meningitidis MC58]
Length = 458
Score = 101 bits (249), Expect = 2e-20
Identities = 108/432 (25%), Positives = 198/432 (45%), Gaps = 73/432 (16%)
Query: 30 DVEAALARAH----------AKLGNIPEESARVISERANTKWVKLERVKEIEAEIHHDIM 79
D++ +LA A L +I A ++ E + K +E ++E ++H M
Sbjct: 35 DIQGSLAHAQMLKETGVLDEGDLADIRRGMAEILEEIRSGK---IEWSSDLE-DVH---M 87
Query: 80 AVVKALSEVCGEHGKYVHLGATSNDIIDTANALLIKESLAIVEKDLKELRSILKELAKKH 139
+ + L++ G+ GK +H G + ND + T L +++ + +++ ++ L++ L +LA+++
Sbjct: 88 NIERRLTDKIGDAGKRLHTGRSRNDQVATDIRLWLRDQITVIQSLIQSLQTALLDLAEQN 147
Query: 140 IDTVCIGRTHGQHAVPTTYGMKFALWLDEIQRHIERLQQLKDRVLVGKMRGAVGTAASFG 199
+TV G TH Q A P ++G +++ + R ER+ + RV R +G AA G
Sbjct: 148 AETVMPGFTHLQVAQPVSFGHHMLAYVEMLGRDNERMADCRCRV----NRMPLGAAALAG 203
Query: 200 DKAFEIEKLVMEDLGLKPARITNQIIQRDVYAELMFFLALVASTLDKMA----------- 248
T IQR++ AEL+ F + ++LD ++
Sbjct: 204 ---------------------TTYPIQREITAELLGFEQICQNSLDAVSDRDFAIEFTAA 242
Query: 249 -----LEIRNLQRTEILEVSEPFGEKQV------GSSTMPHKRNPIRTEKVCGLA-RVL- 295
+ + L IL +S FG + GSS MP K+NP E V G + RV+
Sbjct: 243 ASLVMVHLSRLSEELILWMSPRFGFIDIADRFCTGSSIMPQKKNPDVPELVRGKSGRVIG 302
Query: 296 -YSNVIPALLNNPLWHERDLTNSSVERVILPESFVLLDEMLKVMKKVLKGLEFFPENIKR 354
+I + + PL + +D N + + + L+D L++ +++G+ P+N++
Sbjct: 303 HLIGLITLMKSQPLAYNKD--NQEDKEPLFDTADTLID-TLRIYADMMRGVTVKPDNMR- 358
Query: 355 NLYLTKNLIMAEPLMLKLAEKGMGRQEAHELVRQLAMKAFKEGRDLLEVVRKNEEAMKYL 414
+ + A L L +KGM ++AHE+V Q A + G DL E+ + + L
Sbjct: 359 -AAVMQGFATATDLADYLVKKGMPFRDAHEVVAQAVRHADQAGVDLSELPLEVLQGFSDL 417
Query: 415 TENDLEG-LKPE 425
+D+ G L PE
Sbjct: 418 IADDVYGVLTPE 429
>pir||D82666 adenylosuccinate lyase XF1553 [imported] - Xylella fastidiosa
(strain 9a5c) >gi|9106596|gb|AAF84362.1|AE003985_3
(AE003985) adenylosuccinate lyase [Xylella fastidiosa]
Length = 532
Score = 101 bits (248), Expect = 2e-20
Identities = 130/465 (27%), Positives = 205/465 (43%), Gaps = 43/465 (9%)
Query: 1 MAVHPIDYRYGS--EEMRRVWEEENKLQKLLDVEAALARAHAKLGNIPEESARVISE--- 55
+A+ P+D RY S + +R ++ E ++ + VE A A A NI E + ++
Sbjct: 84 LALSPLDGRYLSKVDTLRPIFSEYGLIKARVKVEIAWLLALAAEPNIVELAPFSVAAQTR 143
Query: 56 -RANTKWVKLE---RVKEIEAEIHHDIMAVVKALSEVCGEHGK------YVHLGATSNDI 105
RA + +E RVKEIE +HD+ AV + E + + +VH TS DI
Sbjct: 144 LRALADGLTIEHAARVKEIEHTTNHDVKAVEYFIKEQLKDDTELRPGLEFVHFACTSEDI 203
Query: 106 IDTANALLIKESLA-IVEKDLKELRSILKELAKKHIDTVCIGRTHGQHAVPTTYGMKFAL 164
+ + +L+++++ ++ L + + L+ LA + RTHGQ A PTT G + A
Sbjct: 204 NNLSYSLMLQQARNDVLLPTLDGIATHLRTLAHTQAAQPMLSRTHGQTASPTTLGKEIAN 263
Query: 165 WLDEIQRHIERLQQLKDRVLVGKMRGAVGTAASFGDKAFEIE-----KLVMEDLGLKPAR 219
+ ++R + Q+ L GK+ GAVG + EI + +E LGL
Sbjct: 264 VVARLER---QRHQIATIALSGKINGAVGNYNAHTISYPEINWPAFAQRFVESLGLVFNP 320
Query: 220 ITNQIIQRDVYAELMFFLALVASTLDKMALEIRNLQRTEILEVSEPFGEKQVGSSTMPHK 279
T QI D AE+ + L +A ++ + + E +VGSSTMPHK
Sbjct: 321 YTTQIEPHDTIAEISDATRRANTILIDLARDLWGY--ISLGYFKQKLKEGEVGSSTMPHK 378
Query: 280 RNPIRTEKV---CGLARVLYSNVIPALLNNPLWHERDLTNSSVERVILPESFVLLDEMLK 336
NPI E G+A L+ + L W +RDLT+S+V R L +F L
Sbjct: 379 VNPIDFENAEGNFGVANALFEH-FSTKLPISRW-QRDLTDSTVLRA-LGTAFGHTQVALD 435
Query: 337 VMKKVLKGLEFFPENIKRNLYLTKNLIMAEPLMLKLAEKGMGRQEAHELVRQLAMKAFKE 396
+ K L L PE I +L A ++ + + M R QL KA
Sbjct: 436 SLNKGLHKLSPNPERI------DADLDAAWEVLAEAVQTIMRRHNLPNPYEQL--KALTR 487
Query: 397 GRDL-LEVVRKNEEAMKYLTE--NDLEGLKPENYIGKAREIVENV 438
G+ + + +R E + TE L L P Y G A+++ N+
Sbjct: 488 GQGITADSMRAFIETLDLPTEAKQRLHDLTPRAYTGLAKQLALNI 532
>pir||F81793 adenylosuccinate lyase (EC 4.3.2.2) NMA2203 [imported] - Neisseria
meningitidis (group A strain Z2491)
>gi|7380822|emb|CAB85414.1| (AL162758) adenylosuccinate
lyase [Neisseria meningitidis Z2491]
Length = 456
Score = 100 bits (246), Expect = 4e-20
Identities = 131/469 (27%), Positives = 207/469 (43%), Gaps = 51/469 (10%)
Query: 2 AVHPIDYRYGS--EEMRRVWEEENKLQKLLDVEAALARAHA---KLGNIPEESARVISER 56
++ P+D RY E +R ++ E ++ + VE +A A K+ +P SA ++E
Sbjct: 7 SLSPLDGRYAQSVEALRPIFSEYGLMKARVKVELNWLKALAAEPKIAEVPPFSAETLAEI 66
Query: 57 ----ANTKWVKLERVKEIEAEIHHDIMAVV----KALSEV--CGEHGKYVHLGATSNDII 106
N VK IEA +HD+ A+ K +EV +++H TS DI
Sbjct: 67 DTVIENFSLEDAAAVKAIEATTNHDVKAIEYWLKKRFAEVPEVAAVSEFIHFACTSEDIN 126
Query: 107 DTANALLIKESL-AIVEKDLKELRSILKELAKKHIDTVCIGRTHGQHAVPTTYGMKFALW 165
+ ++AL+++E+ A++ L E+ L +A + RTHGQ A PTT G + A
Sbjct: 127 NLSHALMLQEAREAVLLPKLAEIIEKLTAMAHDLAAVPMMSRTHGQPATPTTLGKETANV 186
Query: 166 LDEIQRHIERLQQLKDRVLVGKMRGAVGT----AASFGDKAFE--IEKLVMEDLGLKPAR 219
+ +QR + LQ + +GK+ GAVG ++ D +E V LGL
Sbjct: 187 VYRLQRQFKSLQA---QEFLGKINGAVGNYNAHMVAYPDVDWETHCRNFVEISLGLTFNP 243
Query: 220 ITNQIIQRDVYAELMFFLALVASTLDKMALEIRNLQRTEILEVSEPFGEKQVGSSTMPHK 279
T QI D AE L+ + + L ++ + GE VGSSTMPHK
Sbjct: 244 YTIQIEPHDYMAEFFQTLSRINTILIDFNRDVWGYISLGYFKQKVKAGE--VGSSTMPHK 301
Query: 280 RNPIRTEKVCGLARVLYSNVIPALLNNPL----WHERDLTNSSVERVI-LPESFVLLDEM 334
NPI E G + +N + L L W +RDLT+S+V R + + + +L
Sbjct: 302 VNPIDFENSEG--NLGMANAVLGFLAEKLPISRW-QRDLTDSTVLRNMGVGVGYAVLG-- 356
Query: 335 LKVMKKVLKGLEFFPENIKRNLYLTKNLIMAEPLMLKLAEKGMGR--QEAHELVR---QL 389
+ L LE P + +L T L +AEP+ + G+ ++ +L R +
Sbjct: 357 FAAHLRGLNKLEPNPAALAADLDATWEL-LAEPIQTVMRRYGVANPYEKLKDLTRGKGGI 415
Query: 390 AMKAFKEGRDLLEVVRKNEEAMKYLTENDLEGLKPENYIGKAREIVENV 438
+ K LLE+ EA L E L P Y+GKA + + +
Sbjct: 416 TPEVLKGFIGLLEI---PAEAKAKLLE-----LTPALYVGKAEALAKRI 456
>sp|O67383|ARLY_AQUAE ARGININOSUCCINATE LYASE (ARGINOSUCCINASE) (ASAL)
>gi|7437150|pir||D70419 argininosuccinate lyase -
Aquifex aeolicus >gi|2983783|gb|AAC07341.1| (AE000737)
argininosuccinate lyase [Aquifex aeolicus]
Length = 457
Score = 99.5 bits (244), Expect = 7e-20
Identities = 117/442 (26%), Positives = 198/442 (44%), Gaps = 45/442 (10%)
Query: 30 DVEAALARAHA--KLGNIPEESARVISE-----RANTKWVKLERVKEIEAEIHHDIMAVV 82
D+E +A K G + EE AR + + + K K + KE+E ++H +I A
Sbjct: 34 DIEQDIAHVKTLQKAGILTEEEARELIQELLKIKEEIKEGKFQWKKELE-DVHMNIEA-- 90
Query: 83 KALSEVCGEHGKYVHLGATSNDIIDTANALLIKESLAIVEKDLKELRSILKELAKKHIDT 142
L G+ G+ +H + ND + T L +K+ + V + LKELR L ELA+ +D
Sbjct: 91 -ELINRLGDVGRKLHTARSRNDQVATDEKLYLKKEIKEVLQLLKELRKTLVELAETTVDF 149
Query: 143 VCIGRTHGQHAVPTTYGMKFALWLDEIQRHIERLQQLKDRVLVGKMRGAVGTAASFGDKA 202
V TH Q A P F + + + + ERL RV +G+ A G
Sbjct: 150 VMPSYTHLQRAQPIRVAHYFLAYREILLKDSERLMDTYRRV----DELPLGSGAVAG-VD 204
Query: 203 FEIEKLVMEDLGLKPARITNQII----QRDVYAELMFFLALVASTLDKMA--LEIRNLQR 256
F +++ +L L R+T + +RD E + AL+A L ++A L I N +
Sbjct: 205 FPLDRFYTAEL-LGFNRVTRNSMYATAERDFIIEFLSNCALIAQHLSRLAEDLIIWNTEE 263
Query: 257 TEILEVSEPFGEKQVGSSTMPHKRNPIRTEKVCGLARVLYSNVIPALLNN----PLWHER 312
+E+ + + GSS MP K+NP E + G +Y N+I ALL P+ + R
Sbjct: 264 FNFVELPD---KLCTGSSIMPQKKNPDVLELIRGKTGRIYGNLI-ALLTTMKALPMAYNR 319
Query: 313 DLTNSSVERVILPESFVLLDEMLKVMKKVLKGLEFFPENIKRNLYLTKNLIMAEPLMLKL 372
D+ ++ L ++ L M+K M VL L +N+++ + N ++ + L
Sbjct: 320 DMQE---DKEPLFDTLKNLKNMIKGMTLVLSDLRVKEQNMRK---ASGNFLLITDIANYL 373
Query: 373 AEKGMGRQEAHELVRQLAMKAFKEGRDLLEVVRKNEEAMKYLTENDL-EGLKPEN----- 426
EKG+ + AH + + ++G+ L E+ + + E D+ + L PE
Sbjct: 374 VEKGVPFRTAHHIAGSIVAYLLEKGKKLEEMTLEEFKQFSEKFEEDVFDILSPERAADRK 433
Query: 427 --YIGKAREIVENVVNYVEEME 446
Y G A+E + ++ + E
Sbjct: 434 RVYGGTAKEEILRIIEVAKAEE 455
>sp|P44797|PUR8_HAEIN ADENYLOSUCCINATE LYASE (ADENYLOSUCCINASE) (ASL)
>gi|1573637|gb|AAC22299.1| (U32747) adenylosuccinate
lyase (purB) [Haemophilus influenzae Rd]
Length = 456
Score = 98.7 bits (242), Expect = 1e-19
Identities = 125/470 (26%), Positives = 212/470 (44%), Gaps = 55/470 (11%)
Query: 2 AVHPIDYRYGSE--EMRRVWEEENKLQKLLDVEAALARAHAKLGNIPE-------ESARV 52
A+ P+D RY + +R ++ E ++ + VE + A +I E +A +
Sbjct: 8 ALSPLDGRYQDKVTPLRAIFSEFGLMKFRVAVEVRWLQKLASTADITEVPPFSTQANAFL 67
Query: 53 ISERANTKWVKLERVKEIEAEIHHDIMAVVKALSEVCGEH------GKYVHLGATSNDII 106
AN R+KEIE +HD+ AV L E +++H TS DI
Sbjct: 68 DGIVANFNEADAARIKEIERTTNHDVKAVEYFLKEKIQNEVELVKVSEFIHFACTSEDIN 127
Query: 107 DTANALLIKESLAIVEKDLKELRSILKE---LAKKHIDTVCIGRTHGQHAVPTTYGMKFA 163
+ ++AL++ S A E L E + ++ E LA+++ + RTHGQ A P+T G + A
Sbjct: 128 NLSHALML--STARDEVILPEWQKLIDEITRLAEEYKTIPLLSRTHGQPASPSTVGKEMA 185
Query: 164 LWLDEIQRHIERLQQLKDRVLVGKMRGAVGT-----AASFGDKAFEIEKLVMEDLGLKPA 218
+ ++R ++LQ + ++GK+ GAVG +A + + + LG++
Sbjct: 186 NVVYRLKRQFKQLQNAE---ILGKINGAVGNYNAHLSAYPNIDWHKFSEEFVTSLGIQWN 242
Query: 219 RITNQIIQRDVYAELMFFLALVASTLDKMALEIRNLQRTEILEVSEPFGEKQVGSSTMPH 278
T QI D E FF A+V + + + + ++GSSTMPH
Sbjct: 243 PYTTQIEPHDYITE--FFDAVVRFNTIIIDFDRDLWGYIALNHFKQRTIAGEIGSSTMPH 300
Query: 279 KRNPI---RTEKVCGLARVLYSNVIPALLNNPLWHERDLTNSSVER---VILPESFVLLD 332
K NPI +E GLA + ++ + L W +RDLT+S+V R V L +
Sbjct: 301 KVNPIDFENSEGNLGLANAVMTH-LGQKLPISRW-QRDLTDSTVLRNLGVGLGYCLIAYA 358
Query: 333 EMLKVMKKVLKGLEFFPENIKRNLYLTKNLIMAEPLMLKLAEKGMGR--QEAHELVR--Q 388
K + K+ E + +N ++AEP+ + G+ + ++ EL R +
Sbjct: 359 STRKGISKLEVNQPHLLEELNQNWE-----VLAEPIQTVMRRYGIEKPYEKLKELTRGKR 413
Query: 389 LAMKAFKEGRDLLEVVRKNEEAMKYLTENDLEGLKPENYIGKAREIVENV 438
+ +A +E D L++ EE ++ L+ L P YIG A E+VE +
Sbjct: 414 VTEQAMREFIDKLDI--PQEEKLR------LQKLTPATYIGAAVELVEKL 455
>pir||D64083 adenylosuccinate lyase (EC 4.3.2.2) - Haemophilus influenzae
(strain Rd KW20)
Length = 507
Score = 98.7 bits (242), Expect = 1e-19
Identities = 125/470 (26%), Positives = 212/470 (44%), Gaps = 55/470 (11%)
Query: 2 AVHPIDYRYGSE--EMRRVWEEENKLQKLLDVEAALARAHAKLGNIPE-------ESARV 52
A+ P+D RY + +R ++ E ++ + VE + A +I E +A +
Sbjct: 59 ALSPLDGRYQDKVTPLRAIFSEFGLMKFRVAVEVRWLQKLASTADITEVPPFSTQANAFL 118
Query: 53 ISERANTKWVKLERVKEIEAEIHHDIMAVVKALSEVCGEH------GKYVHLGATSNDII 106
AN R+KEIE +HD+ AV L E +++H TS DI
Sbjct: 119 DGIVANFNEADAARIKEIERTTNHDVKAVEYFLKEKIQNEVELVKVSEFIHFACTSEDIN 178
Query: 107 DTANALLIKESLAIVEKDLKELRSILKE---LAKKHIDTVCIGRTHGQHAVPTTYGMKFA 163
+ ++AL++ S A E L E + ++ E LA+++ + RTHGQ A P+T G + A
Sbjct: 179 NLSHALML--STARDEVILPEWQKLIDEITRLAEEYKTIPLLSRTHGQPASPSTVGKEMA 236
Query: 164 LWLDEIQRHIERLQQLKDRVLVGKMRGAVGT-----AASFGDKAFEIEKLVMEDLGLKPA 218
+ ++R ++LQ + ++GK+ GAVG +A + + + LG++
Sbjct: 237 NVVYRLKRQFKQLQNAE---ILGKINGAVGNYNAHLSAYPNIDWHKFSEEFVTSLGIQWN 293
Query: 219 RITNQIIQRDVYAELMFFLALVASTLDKMALEIRNLQRTEILEVSEPFGEKQVGSSTMPH 278
T QI D E FF A+V + + + + ++GSSTMPH
Sbjct: 294 PYTTQIEPHDYITE--FFDAVVRFNTIIIDFDRDLWGYIALNHFKQRTIAGEIGSSTMPH 351
Query: 279 KRNPI---RTEKVCGLARVLYSNVIPALLNNPLWHERDLTNSSVER---VILPESFVLLD 332
K NPI +E GLA + ++ + L W +RDLT+S+V R V L +
Sbjct: 352 KVNPIDFENSEGNLGLANAVMTH-LGQKLPISRW-QRDLTDSTVLRNLGVGLGYCLIAYA 409
Query: 333 EMLKVMKKVLKGLEFFPENIKRNLYLTKNLIMAEPLMLKLAEKGMGR--QEAHELVR--Q 388
K + K+ E + +N ++AEP+ + G+ + ++ EL R +
Sbjct: 410 STRKGISKLEVNQPHLLEELNQNWE-----VLAEPIQTVMRRYGIEKPYEKLKELTRGKR 464
Query: 389 LAMKAFKEGRDLLEVVRKNEEAMKYLTENDLEGLKPENYIGKAREIVENV 438
+ +A +E D L++ EE ++ L+ L P YIG A E+VE +
Sbjct: 465 VTEQAMREFIDKLDI--PQEEKLR------LQKLTPATYIGAAVELVEKL 506
>gb|AAF66620.1|AF143209_1 (AF143209) argininosuccinate lyase [Nostoc PCC73102]
Length = 461
Score = 98.3 bits (241), Expect = 2e-19
Identities = 98/398 (24%), Positives = 187/398 (46%), Gaps = 41/398 (10%)
Query: 27 KLLDVEAALARAHAKLGNIPEESARVISERANTKWVKLERVKE----------IEAEIHH 76
+L++ + ++AHAK+ + + SE LE++++ ++AE H
Sbjct: 31 ELIEYDLTGSQAHAKM---LAHTGIISSEEGEQLVAGLEQIRQEHRQGKFHPGVDAEDVH 87
Query: 77 DIMAVVKALSEVCGEHGKYVHLGATSNDIIDTANALLIKESLAIVEKDLKELRSILKELA 136
AV + L+E+ G+ GK +H + ND + T L +++ + ++ +L+E + +L ++A
Sbjct: 88 --FAVERRLTEIVGDVGKKLHTARSRNDQVGTDTRLYLRDQIQQIKSELREFQGVLLDIA 145
Query: 137 KKHIDTVCIGRTHGQHAVPTTYGMKFALWLDEIQRHIERLQQLKDRVLVGKMR-GAVGTA 195
+KH++T+ G TH Q A P + + QR ERL + RV + + GA+
Sbjct: 146 EKHVETLIPGYTHLQRAQPVSLAHHLLAYFQMAQRDWERLGDVSRRVNISPLGCGALAGT 205
Query: 196 ASFGDKAFEIEKLVMEDLGLKPARITNQIIQRDVYAELMFFLALVASTLDKMALEIRNLQ 255
D+ + + L +++ A + + RD E + +L+ L ++A E+
Sbjct: 206 TFPIDRHYTAKLLDFDNI---YANSLDGVSDRDFAIEFLCAASLIMVHLSRLAEEV---- 258
Query: 256 RTEILEVSEPF------GEKQVGSSTMPHKRNPIRTEKVCGLARVLYSNVIPALL---NN 306
IL SE F GSS MP K+NP E V G ++ ++ L+
Sbjct: 259 ---ILWSSEEFRFVILKDSCATGSSIMPQKKNPDVPELVRGKTGRVFGHLQAMLVIMKGL 315
Query: 307 PLWHERDLTNSSVERVILPESFVLLDEMLKVMKKVLK-GLEFFPENIKRNLYLTKNLIMA 365
PL + +DL ++ L +S + L+ M +L+ GLEF + + + +T+N A
Sbjct: 316 PLAYNKDLQE---DKEGLFDSVNTVKASLEAMTILLREGLEFRTQRLAQ--AVTENFSNA 370
Query: 366 EPLMLKLAEKGMGRQEAHELVRQLAMKAFKEGRDLLEV 403
+ LA +G+ +EA+ LV ++ + G+ L ++
Sbjct: 371 TDVADYLAARGVPFREAYNLVGKVVKTSIAAGKLLKDL 408
>sp|P57351|PUR8_BUCAI ADENYLOSUCCINATE LYASE (ADENYLOSUCCINASE) (ASL)
>gi|10038938|dbj|BAB12973.1| (AP001118) adenylosuccinate
lyase [Buchnera sp. APS]
Length = 456
Score = 96.0 bits (235), Expect = 8e-19
Identities = 121/472 (25%), Positives = 219/472 (45%), Gaps = 59/472 (12%)
Query: 2 AVHPIDYRYGSEE--MRRVWEEENKLQKLLDVEAALARAHAKLGNIPE----ESARV--- 52
A+ P+D RY + +R ++ E L+ L++E + + I + E +
Sbjct: 8 AISPVDGRYSNLTILLRNIFSEFGFLKYRLNIEVQWLKKIISMSQILDINNIEYKEILFL 67
Query: 53 --ISERANTKWVKLERVKEIEAEIHHDIMAVVKALSEVCGEH------GKYVHLGATSND 104
I E N K L +K IE E +HDI A+ L + ++VH G TS D
Sbjct: 68 DSIVEEFNEKDAIL--IKNIEKETNHDIKALEYFLKNKIAQSKNLLTISEFVHFGCTSED 125
Query: 105 IIDTANALLIKESLAIVEKDL-KELRSILKELAKKHIDTVCIGRTHGQHAVPTTYGMKFA 163
I + A +L+IK++ + L ++ S LK++ K+ + THGQ A P+T G + A
Sbjct: 126 INNIAYSLMIKDARDKIILPLWYKIISTLKKMVFKYQHYPLLSLTHGQPATPSTMGKEIA 185
Query: 164 LWLDEIQRHIERLQQLKDRVLVGKMRGAVGT----AASFGD-KAFEIEKLVMEDLGLKPA 218
+ ++R L++++ ++GK+ G+ G A++ D +I K + G+
Sbjct: 186 NFYYRMKRQYIILKKIE---ILGKINGSTGNYNAHLAAYPDINWHKISKDFITSFGINWN 242
Query: 219 RITNQIIQRDVYAELMFFLALVASTLDKMALEIRNLQRTEILEVSEPFGEKQVGSSTMPH 278
T QI D AE ++L + L ++ + + + ++GSS MPH
Sbjct: 243 PYTTQIEPHDYIAEFFSCMSLFNTILINFNRDMWGY--ISLNYFKQRTIDYEIGSSIMPH 300
Query: 279 KRNPI---RTEKVCGLARVLYSNVIPALLNNPL--WHERDLTNSSVER---VILPESFVL 330
K NPI +E GL+ L +++I L P+ W +RDL++S+V R V + + +
Sbjct: 301 KVNPIDFENSEGNLGLSNALMNHMITKL---PISRW-QRDLSDSTVLRNIGVAISYAIIA 356
Query: 331 LDEMLKVMKKVLKGLEFFPENIKRNLYLTKN-LIMAEPLMLKLAEKGMGRQEAHELVRQL 389
+ +L + K LE + +N L KN I++EP+ + G+ + A+E +++L
Sbjct: 357 YNSVLSGINK----LEINESELLKN--LDKNWSILSEPIQTIMRRYGI--KNAYEKLKKL 408
Query: 390 AMKAFKEGRDLLEVVRKNEEAMKYLTEND---LEGLKPENYIGKAREIVENV 438
G+++ V + + E + L+ + P NYIG A +I+ +
Sbjct: 409 T-----RGKEINRNVIHTFISSLNIPEEEKKRLKNMTPFNYIGAASQIINEI 455
>sp|Q58201|ARLY_METJA ARGININOSUCCINATE LYASE (ARGINOSUCCINASE) (ASAL)
>gi|2127767|pir||G64398 argininosuccinate lyase (EC
4.3.2.1) - Methanococcus jannaschii
>gi|1591489|gb|AAB98785.1| (U67523) argininosuccinate
lyase (argH) [Methanococcus jannaschii]
Length = 484
Score = 95.2 bits (233), Expect = 1e-18
Identities = 106/405 (26%), Positives = 180/405 (44%), Gaps = 29/405 (7%)
Query: 43 GNIPEESARVISERANTKWVKLERVKEIEAEIHHDIMAVVKALSEVCGEH-GKYVHLGAT 101
G I +E A+ I E + K ++ + M + L + GE +H G +
Sbjct: 49 GIIKKEDAKKIIEGLKEIYKKGMENLNLDPSLDDIHMVIESELIKKLGEDVAGRMHTGRS 108
Query: 102 SNDIIDTANALLIKESLAIVEKDLKELRSILKELAKKHIDTVCIGRTHGQHAVPTTYGMK 161
ND + T + ++E + I+ K L ++ + ELA+KH +T+ +G TH QHA P T+
Sbjct: 109 RNDEVATDLRIALREKVLIIAKSLIKMLKDILELAEKHKETLIVGYTHLQHAQPVTFAHH 168
Query: 162 FALWLDEIQRHIERLQQLKDRVLVGKMRGAVGTAASFGDKAFEIEKLVMEDLGLKPARIT 221
++ I+R I RL R+ + + G A+ G F+I + ++L A I
Sbjct: 169 LLSYVSAIERDILRLLDAYKRINISPL--GCGAMATTG---FKINRERTKELLGFDALIE 223
Query: 222 NQ---IIQRDVYAELMFFLALVASTLDKMALEIRNLQRTEI--LEVSEPFGEKQVGSSTM 276
N + RD E M LA++ + L K+ E+ E +E++ F SS M
Sbjct: 224 NSMDGVSARDFILETMADLAILGTNLSKICEELILFSTYEFGTIEIANEFCST---SSIM 280
Query: 277 PHKRNPIRTEKVCGLARVLYSNVIPALL---NNPLWHERDLTNSSVERVILPESFVLLDE 333
P K+NP E L N++ AL P + RDL S L +S +
Sbjct: 281 PQKKNPDVAEIARAKLSKLNGNLVTALTILKALPNTYNRDLQEISPH---LWDSVYTTID 337
Query: 334 MLKVMKKVLKGLEFFPENIKRNLYLTKNLIMAEPLMLKLAEKGMGRQEAHELVRQLAMKA 393
+K++ +LK ++ E ++ L E + E G+ + AH +V ++ ++
Sbjct: 338 TIKMVHGMLKTIKINKERME-ELAKANYSTATELADTLVRETGIPFRTAHGIVGEVVRRS 396
Query: 394 FKEGRDLLEVVRKNEEAMKYLTENDLEGLKPENYIGKAREIVENV 438
+E +D++EV+ E KY + D E +K KA + ENV
Sbjct: 397 IEEKKDMIEVI--YEVLEKYNLKVDEEKIK------KALDPYENV 433
>sp|P05083|CRD2_CHICK DELTA CRYSTALLIN II (ARGININOSUCCINATE LYASE >gi|68370|pir||CYCHD2
delta-2-crystallin - chicken >gi|211673|gb|AAA48727.1|
(M10806) delta-2 crystallin [Gallus gallus]
Length = 466
Score = 92.8 bits (227), Expect = 7e-18
Identities = 111/429 (25%), Positives = 195/429 (44%), Gaps = 42/429 (9%)
Query: 29 LDVEAALARAHA--KLGNIPE-ESARVIS--ERANTKWVK-LERVKEIEAEIHHDIMAVV 82
+D++ ++A A A K G + + E +++S E+ + +W K + VK+ + +IH A
Sbjct: 37 VDIQGSMAYAKALEKAGILTKTELEKILSGLEKISEEWSKGVFVVKQSDEDIH---TANE 93
Query: 83 KALSEVCGEHGKYVHLGATSNDIIDTANALLIKESLAIVEKDLKELRSILKELAKKHIDT 142
+ L E+ G+ +H G + ND + T LL+K S++++ L +L L E A ID
Sbjct: 94 RRLKELIGDIAGKLHTGRSRNDQVVTDLKLLLKSSISVISTHLLQLIKTLVERAATEIDV 153
Query: 143 VCIGRTHGQHAVPTTYGMKFALWLDEIQRHIERLQQLKDRVLVGKMRGAVGTAASFGDKA 202
+ G TH Q A+P + + R ERL ++K R+ V + G+ A G+
Sbjct: 154 IMPGYTHLQKALPIRWSQFLLSHAVALIRDSERLGEVKKRMSVLPL----GSGALAGNPL 209
Query: 203 FEIEKLVMEDLGLKPARITNQ--IIQRDVYAELMFFLALVASTLDKMALEIRNLQRTE-- 258
+L+ +L + + I +RD EL+ L+ L K+A ++ TE
Sbjct: 210 EIDRELLRSELDFASISLNSMDAISERDFVVELLSVATLLMIHLSKLAEDLIIFSTTEFG 269
Query: 259 ILEVSEPFGEKQVGSSTMPHKRNPIRTEKVCGLARVLYSN---VIPALLNNPLWHERDLT 315
+ +S+ + GSS +P K+NP E + A ++ V+ L P + +DL
Sbjct: 270 FVTLSDAY---STGSSLLPQKKNPDSLELIRSKAGRVFGRLAAVLMVLKGLPSTYNKDLQ 326
Query: 316 NSSVERVILPESFVLLDEMLKVMKKVLKGLEFFPENIKRNLYLTKNLIMAEPLMLKLAEK 375
++ + + L +L+V V+ L+ EN+++ LT L+ + L L L K
Sbjct: 327 E---DKEAVFDVVDTLTAVLQVATGVISTLQVNKENMEK--ALTPELLSTD-LALYLVRK 380
Query: 376 GMGRQEAHELVRQLAMKAFKEGRDLLEVVRKNEEAMKYLTENDLEGLKPENYIGKAREIV 435
GM ++AH + A +G A+ LT DL+ + P V
Sbjct: 381 GMPFRQAHVASGKAVHLAETKG-----------IAINKLTLEDLKSISP--LFASDVSQV 427
Query: 436 ENVVNYVEE 444
N+VN VE+
Sbjct: 428 FNIVNSVEQ 436
>pir||CYDKD2 delta-2-crystallin - duck
Length = 468
Score = 91.3 bits (223), Expect = 2e-17
Identities = 98/368 (26%), Positives = 172/368 (46%), Gaps = 29/368 (7%)
Query: 29 LDVEAALARAHA--KLGNIPE-ESARVIS--ERANTKWVK-LERVKEIEAEIHHDIMAVV 82
+D++ ++A A A K G + + E +++S E+ + +W K + VK+ + +IH A
Sbjct: 39 VDIQGSMAYAKALEKAGILTKTELEKILSGLEKISEEWSKGVFVVKQSDEDIH---TANE 95
Query: 83 KALSEVCGEHGKYVHLGATSNDIIDTANALLIKESLAIVEKDLKELRSILKELAKKHIDT 142
+ L E+ G+ +H G + ND + T L +K SL+I+ L +L L E A ID
Sbjct: 96 RRLKELIGDIAGKLHTGRSRNDQVVTDLKLFMKNSLSIISTHLLQLIKTLVERAAIEIDV 155
Query: 143 VCIGRTHGQHAVPTTYGMKFALWLDEIQRHIERLQQLKDRVLVGKMRGAVGTAASFGDKA 202
+ G TH Q A P + + R ERL ++K R+ V + G+ A G+
Sbjct: 156 ILPGYTHLQKAQPIRWSQFLLSHAVALTRDSERLGEVKKRINVLPL----GSGALAGNPL 211
Query: 203 FEIEKLVMEDLGLKPARITNQ--IIQRDVYAELMFFLALVASTLDKMA--LEIRNLQRTE 258
+++ +L + + I +RD E +F L+ L KMA L I +
Sbjct: 212 DIDREMLRSELEFASISLNSMDAISERDFVVEFLFLATLLMIHLSKMAEDLIIYSTSEFG 271
Query: 259 ILEVSEPFGEKQVGSSTMPHKRNPIRTEKVCGLARVLY---SNVIPALLNNPLWHERDLT 315
L +S+ F GSS MP K+NP E + A ++ ++++ L P + +DL
Sbjct: 272 FLTLSDAF---STGSSLMPQKKNPDSLELIRSKAGRVFGRLASILMVLKGLPSTYNKDLQ 328
Query: 316 NSSVERVILPESFVLLDEMLKVMKKVLKGLEFFPENIKRNLYLTKNLIMAEPLMLKLAEK 375
++ + + L +L+V V+ L+ EN+++ L ++A L L L K
Sbjct: 329 E---DKEAVFDVVDTLTAVLQVATGVISTLQISKENMEKAL---TPEMLATDLALYLVRK 382
Query: 376 GMGRQEAH 383
G+ ++AH
Sbjct: 383 GVPFRQAH 390
>gb|AAG21593.1|AC025781_1 (AC025781) adenylosuccinate lyase-like protein; 104558-106845
[Arabidopsis thaliana]
Length = 518
Score = 91.3 bits (223), Expect = 2e-17
Identities = 109/386 (28%), Positives = 177/386 (45%), Gaps = 40/386 (10%)
Query: 66 RVKEIEAEIHHDIMAVVKALSEVCGEHGK------YVHLGATSNDIIDTANALLIKESLA 119
+VK+IE +HD+ AV L + C H + + H TS DI + ++AL+++E+L+
Sbjct: 138 QVKKIERVTNHDVKAVEYFLKQKCESHPEIAKVLEFFHFACTSEDINNLSHALMLQEALS 197
Query: 120 -IVEKDLKELRSILKELAKKHIDTVCIGRTHGQHAVPTTYGMKFALWLDEIQRHIERLQQ 178
++ + EL + +AK + RTHGQ A PTT G + A++ ++ +ER +
Sbjct: 198 SVILPTMDELIKSISLMAKSFAYVPMLSRTHGQPASPTTLGKEMAIF--AVRLSVER-RY 254
Query: 179 LKDRVLVGKMRGAVG------TAASFGDKAFEIEKLVMEDLGLKPARITNQIIQRDVYAE 232
L + + GK GAVG +A S D E+ V LGL QI D A
Sbjct: 255 LSETKIKGKFAGAVGNYNAHISAYSNIDWPHVAEEFV-TSLGLTFNPYVTQIEPHDYMAR 313
Query: 233 LMFFLALVASTLDKMALEIRNLQRTEILEVSEPFGEKQVGSSTMPHKRNPIRTEKVCGLA 292
L ++ + L +I + + + GE +GSSTMPHK NPI E G
Sbjct: 314 LFNTISQFNNVLIDFDRDIWSY--ISLGYFKQATGE--IGSSTMPHKVNPIDFENSEGNL 369
Query: 293 RVLYSNVIPALLNNPLWH-ERDLTNSSVERVILPESFVLLDEMLKVMKKVLKG---LEFF 348
+ + + P+ +RDLT+S+V L L L K ++G L+
Sbjct: 370 GKANAELAFLSMKLPISRMQRDLTDSTV----LRNMGGALGHSLLAYKSAIQGIGKLQVN 425
Query: 349 PENIKRNLYLTKNLIMAEPLMLKLAEKGMGRQEAHELVRQLAM-KAFKEG--RDLLEVVR 405
+K +L T ++AEP+ + G+ E +E +++L +A E R ++ +
Sbjct: 426 EARLKDDLDHTWE-VLAEPIQTVMRRYGV--PEPYEKLKELTRGRAVNEESIRKFIKSLE 482
Query: 406 KNEEAMKYLTENDLEGLKPENYIGKA 431
EEA ++ L L P Y+G A
Sbjct: 483 LPEEA-----KDQLLKLTPHTYVGAA 503
>emb|CAB59872.1| (AL132764) adenylosuccinate lyase [Leishmania major]
Length = 479
Score = 90.9 bits (222), Expect = 3e-17
Identities = 100/385 (25%), Positives = 169/385 (42%), Gaps = 41/385 (10%)
Query: 67 VKEIEAEIHHDIMAV---VKALSEVCGEHGK--YVHLGATSNDIIDTANALLIKESL--- 118
+K+IEA +HDI AV +K CG + ++H G TS DI +T+ +L++++L
Sbjct: 109 IKDIEAVTNHDIKAVEYYLKDKMSACGLEAEKEFIHFGLTSQDINNTSIPMLLRDALHHH 168
Query: 119 --AIVEKDLKELRSILKELAKKHIDTVCIGRTHGQHAVPTTYGMKFALWLDEIQRHIERL 176
+++ + L+S L E D + RTHGQ A PT +F +W++ ++ L
Sbjct: 169 YIPTLDQLIAHLKSKLPEW-----DVPMLARTHGQPASPTNLAKEFMVWIERLEEQRTML 223
Query: 177 QQLKDRVLVGKMRGAVGT-----AASFGDKAFEIEKLVMED-LGLKPARITNQIIQRDVY 230
+ + GK GA G A G E +L + LGL+ R T QI D
Sbjct: 224 LSIPN---TGKFGGATGNFNAHLCAYPGVNWLEFGELFLSKYLGLRRQRYTTQIEHYDNL 280
Query: 231 AELMFFLALVASTLDKMALEIRNLQRTEILEVSEPFGEKQVGSSTMPHKRNPIRTEKVCG 290
A + A + + L +A ++ + GE VGSS MPHK NPI E G
Sbjct: 281 AAICDACARLHTILMDLAKDVWQYISLGYFDQKVKAGE--VGSSAMPHKVNPIDFENAEG 338
Query: 291 LARVLYSNVIPALLNNPL---WHERDLTNSSVER---VILPESFVLLDEMLKVMKKVLKG 344
+ SN + L+ L +RDLT+S+V R V L + + + + + K+L
Sbjct: 339 --NLGMSNAVLGFLSAKLPISRLQRDLTDSTVLRNLGVPLSHALIAFASLQRGIGKLLLN 396
Query: 345 LEFFPENIKRNLYLTKNLIMAEPLMLKLAEKGMGRQEAHELVRQLAMKAFKEGRDLLEVV 404
+ +++ N ++AE + L +G + +E ++ L + +
Sbjct: 397 KDVIAADLEGNW-----AVVAEGIQTVLRREGY--PKPYEALKDLTRGNAHVTEETVHRF 449
Query: 405 RKNEEAMKYLTENDLEGLKPENYIG 429
+ E + +L + P Y+G
Sbjct: 450 IQQLEGITEEVRQELLAITPFTYVG 474
>sp|Q46104|ARLY_CAMJE ARGININOSUCCINATE LYASE (ARGINOSUCCINASE) (ASAL)
>gi|11269754|pir||B81367 argininosuccinate lyase (EC
4.3.2.1) Cj0931c [imported] - Campylobacter jejuni
(strain NCTC 11168) >gi|6968368|emb|CAB73188.1|
(AL139076) argininosuccinate lyase [Campylobacter
jejuni]
Length = 460
Score = 90.9 bits (222), Expect = 3e-17
Identities = 102/406 (25%), Positives = 183/406 (44%), Gaps = 25/406 (6%)
Query: 12 SEEMRRVWEEENKLQKLL---DVEAALARAHA--KLGNIPEESARVISERANTKWVKLER 66
S+E+ + + + K L D++ ++A A G + +E I + ++E+
Sbjct: 14 SDELLKEFNASLNVDKTLFNEDIQGSIAHATMLESCGILKKEELDAIIKGLEQVRSEIEQ 73
Query: 67 VKEIEAEIHHDI-MAVVKALSEVCG-EHGKYVHLGATSNDIIDTANALLIKESLAIVEKD 124
K I DI MAV K LSE+ G E G +H + ND + T L +K+S + K
Sbjct: 74 GKFIFDIKDEDIHMAVEKRLSEIIGSEIGGRLHTARSRNDQVATDFKLFVKKSHIELIKL 133
Query: 125 LKELRSILKELAKKHIDTVCIGRTHGQHAVPTTYGMKFALWLDEIQRHIERLQQLKDRVL 184
LKEL + E AK H T+ TH QHA P ++ + + R I+RLQ +
Sbjct: 134 LKELIQTMLEHAKVHKKTIMPSFTHLQHAQPVSFSFYILAYAFMLMRDIKRLQNSLELAD 193
Query: 185 VGKMRGAVGTAASFGDKAFEIEKLVMEDLGLKP--ARITNQIIQRDVYAELMFFLALVAS 242
+ G+ A G +L + LG K + + RD +L++ +A++ +
Sbjct: 194 FSPL----GSCACAGTSYAINRELSAKILGFKDIMPNAMDGVSDRDFALDLLYDIAVIFT 249
Query: 243 TLDKMALEIRNLQRTE--ILEVSEPFGEKQVGSSTMPHKRNPIRTEKVCGLARVLYSNVI 300
++ E+ +E + +S+ F GSS MP K+NP E + G +Y N+I
Sbjct: 250 HTSRLCEEMILFSSSEFSFITISDSF---STGSSIMPQKKNPDVCELIRGKTGRVYGNLI 306
Query: 301 PALL---NNPLWHERDLTNSSVERVILPESFVLLDEMLKVMKKVLKGLEFFPENIKRNLY 357
L PL + +D+ ++ + +S + L ++ +LK ++ EN+ N
Sbjct: 307 SLLTIMKALPLAYNKDMQE---DKEGIFDSVKTAKDSLIILNAMLKEIQINKENM-LNAC 362
Query: 358 LTKNLIMAEPLMLKLAEKGMGRQEAHELVRQLAMKAFKEGRDLLEV 403
+L+ + + EK + ++AH +V + +A +G D+ E+
Sbjct: 363 KKGHLLATDLADYLVREKNIPFRKAHFIVGNVVAQAEAQGIDISEI 408
>sp|P24058|CRD2_ANAPL DELTA CRYSTALLIN II (ARGININOSUCCINATE LYASE
>gi|3417287|gb|AAC31658.1| (M35132) delta-2-crystallin
[Anas platyrhynchos]
Length = 468
Score = 90.5 bits (221), Expect = 3e-17
Identities = 98/368 (26%), Positives = 172/368 (46%), Gaps = 29/368 (7%)
Query: 29 LDVEAALARAHA--KLGNIPE-ESARVIS--ERANTKWVK-LERVKEIEAEIHHDIMAVV 82
+D++ ++A A A K G + + E +++S E+ + +W K + VK+ + +IH A
Sbjct: 39 VDIQGSMAYAKALEKAGILTKTELEKILSGLEKISEEWSKGVFVVKQSDEDIH---TANE 95
Query: 83 KALSEVCGEHGKYVHLGATSNDIIDTANALLIKESLAIVEKDLKELRSILKELAKKHIDT 142
+ L E+ G+ +H G + ND + T L +K SL+I+ L +L L E A ID
Sbjct: 96 RRLKELIGDIAGKLHTGRSRNDQVVTDLKLFMKNSLSIISTHLLQLIKTLVERAAIEIDV 155
Query: 143 VCIGRTHGQHAVPTTYGMKFALWLDEIQRHIERLQQLKDRVLVGKMRGAVGTAASFGDKA 202
+ G TH Q A P + + R ERL ++K R+ V + G+ A G+
Sbjct: 156 ILPGYTHLQKAQPIRWSQFLLSHAVALTRDSERLGEVKKRINVLPL----GSGALAGNPL 211
Query: 203 FEIEKLVMEDLGLKPARITNQ--IIQRDVYAELMFFLALVASTLDKMA--LEIRNLQRTE 258
+++ +L + + I +RD E + F L+ L KMA L I +
Sbjct: 212 DIDREMLRSELEFASISLNSMDAISERDFVVEFLSFATLLMIHLSKMAEDLIIYSTSEFG 271
Query: 259 ILEVSEPFGEKQVGSSTMPHKRNPIRTEKVCGLARVLY---SNVIPALLNNPLWHERDLT 315
L +S+ F GSS MP K+NP E + A ++ ++++ L P + +DL
Sbjct: 272 FLTLSDAF---STGSSLMPQKKNPDSLELIRSKAGRVFGRLASILMVLKGLPSTYNKDLQ 328
Query: 316 NSSVERVILPESFVLLDEMLKVMKKVLKGLEFFPENIKRNLYLTKNLIMAEPLMLKLAEK 375
++ + + L +L+V V+ L+ EN+++ L ++A L L L K
Sbjct: 329 E---DKEAVFDVVDTLTAVLQVATGVISTLQISKENMEKAL---TPEMLATDLALYLVRK 382
Query: 376 GMGRQEAH 383
G+ ++AH
Sbjct: 383 GVPFRQAH 390
>sp|P50514|ARLZ_SCHPO PROBABLE ARGININOSUCCINATE LYASE (ARGINOSUCCINASE) (ASAL)
>gi|7492402|pir||T39462 probable argininosuccinate lyase
(EC 4.3.2.1) - fission yeast (Schizosaccharomyces pombe)
>gi|619217|gb|AAA58961.1| (U13259) L-argininosuccinate
lyase [Schizosaccharomyces pombe]
>gi|5579048|emb|CAB51335.1| (AL096874) probable
argininosuccinate lyase (EC 4.3.2.1)
[Schizosaccharomyces pombe]
Length = 460
Score = 88.9 bits (217), Expect = 1e-16
Identities = 91/375 (24%), Positives = 165/375 (43%), Gaps = 39/375 (10%)
Query: 83 KALSEVCGEH--GKYVHLGATSNDIIDTANALLIKESLAIVEKDLKELRSILKELAKKHI 140
+ L E+ G GK +H G + ND + T L +++ L I++K L L + A+ +
Sbjct: 93 RRLGEIIGTGIAGK-LHTGRSRNDQVTTDMRLWLRDELDIIQKSLVGLLQVFVARAESDL 151
Query: 141 DTVCIGRTHGQHAVPTTYGMKFALWLDEIQRHIERLQQLKDRVLVGKMRGAVGTAASFGD 200
D + G TH Q A P + I ++RL+Q+ RV R +G A G+
Sbjct: 152 DIIMPGYTHLQRAQPIRWSHFLLSHAFSILNDLDRLKQIYSRV----NRLPLGAGALAGN 207
Query: 201 KAFEIEKLVMEDLGLKPARIT--NQIIQRDVYAELMFFLALVASTLDKMA--LEIRNLQR 256
K + ++LG + + N + RD E MF+ ++V + + ++A L I +
Sbjct: 208 PFAVDRKFLQKELGFEGVIMNSMNAVADRDYVIEFMFWASMVMTHISRLAEDLIIYSTSE 267
Query: 257 TEILEVSEPFGEKQVGSSTMPHKRNPIRTEKVCGLARVLYSNVIPALLN---NPLWHERD 313
+ +S+ + GSS MP K+NP E + G + ++ N++ +++ P + +D
Sbjct: 268 FNFVTLSDAY---STGSSIMPQKKNPDSLELLRGKSGRVFGNMMGFMVSVKGIPSTYNKD 324
Query: 314 LTNSSVERVILPESFVLLDEMLKVMKKVLKGLEFFPENIKRNLYLTKNLIMAEPLMLKLA 373
L + + S +LD ++++ VL L PENI ++L ++A L L
Sbjct: 325 LQED--KEPLFDSSKTVLDS-IQILTGVLSTLTVNPENIAKSLTAD---MLATDLAEYLV 378
Query: 374 EKGMGRQEAHELVRQLAMKAFKEGRDLLEVVRKNEEAMKYLTENDLEGLKPENYIGKARE 433
KG+ +E H + + + + + L+ D + L P E
Sbjct: 379 RKGVPFRETHHI-----------SGSAVRMAEERNTTIDKLSVEDFKSLHP-----LYEE 422
Query: 434 IVENVVNYVEEMERR 448
V +V NY +E+R
Sbjct: 423 DVADVFNYESSVEKR 437
>sp|Q01592|CRD1_COLLI DELTA CRYSTALLIN (ARGININOSUCCINATE LYASE >gi|478770|pir||S29247
argininosuccinate lyase (EC 4.3.2.1) - pigeon
>gi|62718|emb|CAA47031.1| (X66404) argininosuccinate
lyase [Columba livia]
Length = 466
Score = 88.2 bits (215), Expect = 2e-16
Identities = 110/434 (25%), Positives = 190/434 (43%), Gaps = 42/434 (9%)
Query: 29 LDVEAALARAHA--KLGNIPE-ESARVIS--ERANTKWVK-LERVKEIEAEIHHDIMAVV 82
+D++ ++A A A K G + + E + +S E+ + +W K + V + +IH A
Sbjct: 37 VDIQGSMAYAKALEKAGILSKSELEKTLSGLEKISEEWSKGVFVVTPTDEDIH---TANE 93
Query: 83 KALSEVCGEHGKYVHLGATSNDIIDTANALLIKESLAIVEKDLKELRSILKELAKKHIDT 142
+ L E+ G+ +H G + ND + T L +K SL+++ L +L L E A +D
Sbjct: 94 RRLKELIGDIAGKLHTGRSRNDQVVTDLKLFMKNSLSVISTHLLQLIKTLVERAAIEVDV 153
Query: 143 VCIGRTHGQHAVPTTYGMKFALWLDEIQRHIERLQQLKDRVLVGKMRGAVGTAASFGDKA 202
+ G TH Q P + + R ERL ++K R+ + + G+ A G+
Sbjct: 154 ILPGYTHLQKTQPIRWSQFLLSHAVALTRDSERLGEIKKRINILPL----GSGALAGNPL 209
Query: 203 FEIEKLVMEDLGLKPARITNQ--IIQRDVYAELMFFLALVASTLDKMA--LEIRNLQRTE 258
+L+ +L + + + QRD E + AL+ L KMA L I +
Sbjct: 210 EIDRELLRSELDFASISLNSMDAVRQRDSVVEFLSVAALLMIHLSKMAEDLIIYSTSEFG 269
Query: 259 ILEVSEPFGEKQVGSSTMPHKRNPIRTEKVCGLARVLYSN---VIPALLNNPLWHERDLT 315
L +S+ + GSS MP K+NP E + A ++ ++ L P + +DL
Sbjct: 270 FLTLSDTY---CTGSSVMPQKKNPDSLELIRSKAGRVFGRLAAILMVLKGLPSTYNKDLQ 326
Query: 316 NSSVERVILPESFVLLDEMLKVMKKVLKGLEFFPENIKRNLYLTKNLIMAEPLMLKLAEK 375
++ + + L+ +L+V V+ L+ EN+++ L I++ L L L K
Sbjct: 327 E---DKEAVFDVVDTLNAVLQVATGVISTLQINKENMEKAL---SPEILSSDLALYLVHK 380
Query: 376 GMGRQEAHELVRQLAMKAFKEGRDLLEVVRKNEEAMKYLTENDLEGLKPENYIGKAREIV 435
GM ++AH + A +G L L+ +DL+ + P G V
Sbjct: 381 GMPFRQAHVASGKAVHLAESKGITL-----------NNLSLDDLKSISP--LFGSDVSQV 427
Query: 436 ENVVNYVEEMERRG 449
NVVN VE+ G
Sbjct: 428 FNVVNSVEQYTALG 441
>dbj|BAB06905.1| (AP001518) argininosuccinate lyase [Bacillus halodurans]
Length = 458
Score = 87.8 bits (214), Expect = 2e-16
Identities = 92/414 (22%), Positives = 191/414 (45%), Gaps = 27/414 (6%)
Query: 30 DVEAALARAHA--KLGNIPEESARVISERANTKWVKLERVKEIEAEI---HHDI-MAVVK 83
D+E +LA K G + E I + + + LE+ K+ E + DI + + K
Sbjct: 34 DIEGSLAHVTMLEKSGILANEEVEQIKKGLH---ILLEKAKKGELNYSVANEDIHLNIEK 90
Query: 84 ALSEVCGEHGKYVHLGATSNDIIDTANALLIKESLAIVEKDLKELRSILKELAKKHIDTV 143
L + G G +H G + ND + T L +++ + + +K +++ L E AK+H++T+
Sbjct: 91 LLIDEIGPVGGKLHTGRSRNDQVATDMHLYLRKQTKEILQLVKNVQAALVEQAKQHVETL 150
Query: 144 CIGRTHGQHAVPTTYGMKFALWLDEIQRHIERLQQLKDRVLVGKMRGAVGTAASFG-DKA 202
G TH Q A P ++ + ++R R + R+ V + +F D+
Sbjct: 151 IPGYTHLQRAQPISFAHHLLAYFWMLERDYGRYEDSLKRLNVSPLGAGALAGTTFPIDRE 210
Query: 203 FEIEKLVMEDLGLKPARITNQIIQRDVYAELMFFLALVASTLDKMALE--IRNLQRTEIL 260
+ E L + + + + RD E + +L+ + L ++ E + + Q + +
Sbjct: 211 YTAELLGFDGI---YENSLDAVSDRDFIVEFLSASSLLMTHLSRLCEELILWSSQEFQFV 267
Query: 261 EVSEPFGEKQVGSSTMPHKRNPIRTEKVCGLARVLYS---NVIPALLNNPLWHERDLTNS 317
E+ + F GSS MP K+NP E + G +Y +++ L PL + +D+
Sbjct: 268 EMDDAFA---TGSSIMPQKKNPDMAELIRGKTGRVYGSLFSLLTVLKGLPLAYNKDMQE- 323
Query: 318 SVERVILPESFVLLDEMLKVMKKVLKGLEFFPENIKRNLYLTKNLIMAEPLMLKLAEKGM 377
++ + ++ + L + +++ ++ E + + ++ ++ A L LA KGM
Sbjct: 324 --DKEGMFDAVKTVKGSLAIFAGMIQTMKVKEETMTKAVH--QDFSNATELADYLATKGM 379
Query: 378 GRQEAHELVRQLAMKAFKEGRDLLEVVRKNEEAMKYLTENDL-EGLKPENYIGK 430
+EAHE+V +L + ++G LL++ + +A L + D+ + L+P+ + +
Sbjct: 380 PFREAHEVVGKLVLLCIQKGIYLLDLPLSDYKAASDLFDEDIYDVLQPKTVVAR 433
>gb|AAB70982.1| (AF025459) Contains similarity to Pfam domain: PF00206 (lyase_1),
Score=728.0, E-value=1.3e-215, N=1 [Caenorhabditis
elegans]
Length = 501
Score = 87.4 bits (213), Expect = 3e-16
Identities = 96/349 (27%), Positives = 158/349 (44%), Gaps = 34/349 (9%)
Query: 95 YVHLGATSNDIIDTANALLI-KESLAIVEKDLKELRSILKELAKKHIDTVCIGRTHGQHA 153
+V++ +SND TA + + +E + + LK+LR+ L A++ D + IGRTH Q A
Sbjct: 171 HVNMSQSSNDTFPTAMHIAVGREVNSRLLPALKKLRTALHNKAEEFKDIIKIGRTHTQDA 230
Query: 154 VPTTYGMKFALWLDEIQRHIERLQQLKDRVLVGKMRGAVGTAASFG---DKAF--EIEKL 208
VP T G +F+ ++ ++ I R++ R+ A GTA G K F ++
Sbjct: 231 VPLTLGQEFSAYVTQLDNSIARVESTLPRLY---QLAAGGTAVGTGLNTRKGFAEKVAAT 287
Query: 209 VMEDLGLKPARITNQ---IIQRDVYAELMFFLALVASTLDKMALEIRNL---QRTEILEV 262
V E GL N+ + D E+ L VA + K+ +IR L R + E+
Sbjct: 288 VSELTGLPFVTAPNKFEALAAHDALVEVHGALNTVAVSFMKIGNDIRFLGSGPRCGLGEL 347
Query: 263 SEPFGEKQVGSSTMPHKRNPIRTEKVCGLARVLYSNVIPALLNNPLWH-ERDLTNSSVER 321
S P E + GSS MP K NP + E + +A + N + + H E ++ + R
Sbjct: 348 SLP--ENEPGSSIMPGKVNPTQCEAITMVAAQVMGNQVAVSVGGSNGHFELNVFKPLIVR 405
Query: 322 VILPESFVLLDEMLKVMKKVLKGLEFFPENIKRNLYLTKNLIMAEPLMLKLAEKGMGRQE 381
+L + +L D + + G+ +NI + IM E LML A +
Sbjct: 406 NVLQSTRLLADSAVSFTDHCVDGIVANKDNIAK--------IMRESLMLVTA---LNPHI 454
Query: 382 AHELVRQLAMKAFKEGRDLLEVVRKNEEAMKYLTENDL-EGLKPENYIG 429
++ ++A A K G L++ K + LTE + +KPEN +G
Sbjct: 455 GYDNAAKIAKTAHKNGTTLVQEAVK----LGILTEEQFAQWVKPENMLG 499
>pdb|1AUW|A Chain A, H91n Delta 2 Crystallin From Duck >gi|2981710|pdb|1AUW|B
Chain B, H91n Delta 2 Crystallin From Duck
>gi|2981711|pdb|1AUW|C Chain C, H91n Delta 2 Crystallin
From Duck >gi|2981712|pdb|1AUW|D Chain D, H91n Delta 2
Crystallin From Duck
Length = 468
Score = 86.2 bits (210), Expect = 7e-16
Identities = 97/368 (26%), Positives = 171/368 (46%), Gaps = 29/368 (7%)
Query: 29 LDVEAALARAHA--KLGNIPE-ESARVIS--ERANTKWVK-LERVKEIEAEIHHDIMAVV 82
+D++ ++A A A K G + + E +++S E+ + +W K + VK+ + +I+ A
Sbjct: 39 VDIQGSMAYAKALEKAGILTKTELEKILSGLEKISEEWSKGVFVVKQSDEDIN---TANE 95
Query: 83 KALSEVCGEHGKYVHLGATSNDIIDTANALLIKESLAIVEKDLKELRSILKELAKKHIDT 142
+ L E+ G+ +H G + ND + T L +K SL+I+ L +L L E A ID
Sbjct: 96 RRLKELIGDIAGKLHTGRSRNDQVVTDLKLFMKNSLSIISTHLLQLIKTLVERAAIEIDV 155
Query: 143 VCIGRTHGQHAVPTTYGMKFALWLDEIQRHIERLQQLKDRVLVGKMRGAVGTAASFGDKA 202
+ G TH Q A P + + R ERL ++K R+ V + G+ A G+
Sbjct: 156 ILPGYTHLQKAQPIRWSQFLLSHAVALTRDSERLGEVKKRINVLPL----GSGALAGNPL 211
Query: 203 FEIEKLVMEDLGLKPARITNQ--IIQRDVYAELMFFLALVASTLDKMA--LEIRNLQRTE 258
+++ +L + + I +RD E + F L+ L KMA L I +
Sbjct: 212 DIDREMLRSELEFASISLNSMDAISERDFVVEFLSFATLLMIHLSKMAEDLIIYSTSEFG 271
Query: 259 ILEVSEPFGEKQVGSSTMPHKRNPIRTEKVCGLARVLY---SNVIPALLNNPLWHERDLT 315
L S+ F GSS MP K+NP E + A ++ ++++ L P + +DL
Sbjct: 272 FLTDSDAF---STGSSLMPQKKNPDSLELIRSKAGRVFGRLASILMVLKGLPSTYNKDLQ 328
Query: 316 NSSVERVILPESFVLLDEMLKVMKKVLKGLEFFPENIKRNLYLTKNLIMAEPLMLKLAEK 375
++ + + L +L+V V+ L+ EN+++ L ++A L L L K
Sbjct: 329 E---DKEAVFDVVDTLTAVLQVATGVISTLQISKENMEKAL---TPEMLATDLALYLVRK 382
Query: 376 GMGRQEAH 383
G+ ++AH
Sbjct: 383 GVPFRQAH 390
>sp|P24057|CRD1_ANAPL DELTA CRYSTALLIN I >gi|68369|pir||CYDKD1 delta-1-crystallin - duck
>gi|213089|gb|AAC31659.1| (M35133) delta-1-crystallin
[Anas platyrhynchos]
Length = 466
Score = 85.4 bits (208), Expect = 1e-15
Identities = 113/437 (25%), Positives = 187/437 (41%), Gaps = 48/437 (10%)
Query: 29 LDVEAALARAHAKLGNIPEESARVISERANTKWVK-LERVKE-------IEAEIHHDIM- 79
+D++A++A A A E A ++++ K + LE++ E + + DI
Sbjct: 37 VDIQASIAYAKAL------EKAGILTKTELEKILSGLEKISEELSKGVIVVTQSDEDIQT 90
Query: 80 AVVKALSEVCGEHGKYVHLGATSNDIIDTANALLIKESLAIVEKDLKELRSILKELAKKH 139
A + L E+ G+ +H G + N+ + T L +K SL+I+ L +L L E A
Sbjct: 91 ANERRLKELIGDIAGKLHTGRSRNEQVVTDLKLFMKNSLSIISTHLLQLIKTLVERAAIE 150
Query: 140 IDTVCIGRTHGQHAVPTTYGMKFALWLDEIQRHIERLQQLKDRVLVGKMRGAVGTAASFG 199
ID + G TH Q A P + + R ERL ++K R+ V + G+ A G
Sbjct: 151 IDVILPGYTHLQKAQPIRWSQFLLSHAVALTRDSERLGEVKKRINVLPL----GSGALAG 206
Query: 200 DKAFEIEKLVMEDLGLKPARITNQ--IIQRDVYAELMFFLALVASTLDKMA--LEIRNLQ 255
+ +++ +L + + I +RD E + L+ L KMA L I +
Sbjct: 207 NPLDIDREMLRSELEFASISLNSMDAISERDFVVEFLSVATLLLIHLSKMAEDLIIYSTS 266
Query: 256 RTEILEVSEPFGEKQVGSSTMPHKRNPIRTEKVCGLARVLY---SNVIPALLNNPLWHER 312
L +S+ F GSS MP K+NP E + A ++ ++++ L P + +
Sbjct: 267 EFGFLTLSDAF---STGSSLMPQKKNPDSLELIRSKAGRVFGRLASILMVLKGLPSTYNK 323
Query: 313 DLTNSSVERVILPESFVLLDEMLKVMKKVLKGLEFFPENIKRNLYLTKNLIMAEPLMLKL 372
DL E VI + L +L+V V+ L+ EN+++ L ++A L L L
Sbjct: 324 DLQEDK-EAVI--DVVDTLTAVLQVATGVISTLQISKENMEKAL---TPEMLATDLALYL 377
Query: 373 AEKGMGRQEAHELVRQLAMKAFKEGRDLLEVVRKNEEAMKYLTENDLEGLKPENYIGKAR 432
KGM ++AH + A +G A+ LT DL+ + P
Sbjct: 378 VRKGMPFRQAHTASGKAVHLAETKG-----------IAINNLTLEDLKSISP--LFSSDV 424
Query: 433 EIVENVVNYVEEMERRG 449
V N VN VE+ G
Sbjct: 425 SQVFNFVNSVEQYTALG 441
>sp|P33110|CRD1_ANSAN DELTA CRYSTALLIN (ARGININOSUCCINATE LYASE >gi|418805|pir||JN0486
argininosuccinate lyase (EC 4.3.2.1) - goose
>gi|65326|emb|CAA50208.1| (X70855) argininosuccinate
lyase [Anser anser]
Length = 466
Score = 84.7 bits (206), Expect = 2e-15
Identities = 105/441 (23%), Positives = 201/441 (44%), Gaps = 37/441 (8%)
Query: 29 LDVEAALARAHA--KLGNIPE-ESARVIS--ERANTKWVK-LERVKEIEAEIHHDIMAVV 82
+D++A++A A A K G + + E +++S E+ + +W K + V + + +IH A
Sbjct: 37 VDIQASIAYAKALEKAGILTKTELEKILSGLEKISEEWSKGVFVVTQSDEDIH---TANE 93
Query: 83 KALSEVCGEHGKYVHLGATSNDIIDTANALLIKESLAIVEKDLKELRSILKELAKKHIDT 142
+ L E+ G+ ++ G + N+ + T L +K SL+++ L +L L E A ID
Sbjct: 94 RRLKELIGDIAGKLNTGRSRNEQVVTDLKLFMKNSLSVISTHLLQLIKTLVERAAIEIDV 153
Query: 143 VCIGRTHGQHAVPTTYGMKFALWLDEIQRHIERLQQLKDRVLVGKMRGAVGTAASFGDKA 202
+ G TH Q A P + + R ERL ++K R+ V + G+ A G+
Sbjct: 154 ILPGYTHLQKAQPIRWSQFLLSHAVALTRDSERLGEVKRRINVLPL----GSGALAGNPL 209
Query: 203 FEIEKLVMEDLGLKPARITNQ--IIQRDVYAELMFFLALVASTLDKMA--LEIRNLQRTE 258
+++ +L + + I +RD E + L+ L KMA L I +
Sbjct: 210 DIDREMLRSELDFASISLNSMDAISERDFVVEFLSVATLLMIHLSKMAEDLIIYSTSEFG 269
Query: 259 ILEVSEPFGEKQVGSSTMPHKRNPIRTEKVCGLARVLY---SNVIPALLNNPLWHERDLT 315
L +S+ F GSS MP K+NP E + A ++ ++++ L P + +DL
Sbjct: 270 FLTLSDAF---STGSSLMPQKKNPDSLELIRSKAGRVFGRLASILMVLKGLPSTYNKDLQ 326
Query: 316 NSSVERVILPESFVLLDEMLKVMKKVLKGLEFFPENIKRNLYLTKNLIMAEPLMLKLAEK 375
++ + + L +L+V V+ L+ EN+++ LT ++ + L L L K
Sbjct: 327 E---DKEAVFDVVDTLTAVLQVATGVISTLQISKENMEK--ALTPEMLSTD-LALYLVRK 380
Query: 376 GMGRQEAHELVRQLAMKAFKEGRDLLEVVRKNEEAMKYLTENDLEGL-----KPENYI-- 428
GM ++AH + A +G + + ++ +++ L +D+ + E Y
Sbjct: 381 GMPFRQAHTASGKAVHLAETKGITINNLTLEDLKSISPLFSSDVSQVFNFVNSVEQYTAM 440
Query: 429 -GKAREIVENVVNYVEEMERR 448
G A+ V + ++ E+ ++
Sbjct: 441 GGTAKSSVTTQIEHLRELMKK 461
>gb|AAA93048.1| (M77188) argininosuccinate lyase [Campylobacter jejuni]
Length = 459
Score = 83.9 bits (204), Expect = 3e-15
Identities = 90/345 (26%), Positives = 153/345 (44%), Gaps = 29/345 (8%)
Query: 12 SEEMRRVWEEENKLQKLL---DVEAALARAHA--KLGNIPEESARVISERANTKWVKLER 66
S+E+ + + + K L D++ ++A A G + +E I + ++E+
Sbjct: 14 SDELLKEFNASLNVDKTLFNEDIQGSIAHATMLESCGILKKEQLDAIIKGLEQVRSEIEQ 73
Query: 67 VKEIEAEIHHDI-MAVVKALSEVCG-EHGKYVHLGATSNDIIDTANALLIKESLAIVEKD 124
K I DI MAV K LSE+ G E G +H + ND + T L +K+S + K
Sbjct: 74 GKFIFDIKDEDIHMAVEKRLSEIIGSEIGGRLHTARSRNDQVATDFKLFVKKSHIELIKL 133
Query: 125 LKELRSILKELAKKHIDTVCIGRTHGQHAVPTTYGMKFALWLDEIQRHIERLQQLKDRVL 184
KEL + E AK H T+ TH QHA P ++ + + R I+RLQ +
Sbjct: 134 FKELIQTMLEHAKVHKKTIMPSFTHLQHAQPVSFSFYILAYAFMLMRDIKRLQNSLELAD 193
Query: 185 VGKMRGAVGTAASFGDKAFEIEKLVMEDLGLKPARIT--NQIIQRDVYAELMFFLALVAS 242
+ G+ A G +L E LG K + + + RD +L++ +A++ +
Sbjct: 194 FSPL----GSCACAGTSYRTNRELSAEILGFKDIMLNAMDGVSDRDFALDLLYDIAVIFT 249
Query: 243 TLDKMALEIRNLQRTE--ILEVSEPFGEKQVGSSTMPHKRNPIRTEKVCGLARVLYSNVI 300
++ E+ +E + +S+ F GSS MP K+NP E + G +Y N+I
Sbjct: 250 HTSRLCEEMILFSSSEFSFITISDSF---STGSSIMPQKKNPDVCELIRGKTGRVYGNLI 306
Query: 301 ---------PALLNNPLWHERDLTNSSVERVILPESFVLLDEMLK 336
P N + +++ SV+ +S ++L+ MLK
Sbjct: 307 SLLTIMKALPLAYNKDMQEDKEGIFDSVKTA--KDSLIILNAMLK 349
>pir||S32580 argininosuccinate lyase (EC 4.3.2.1) - fission yeast
(Schizosaccharomyces pombe)
Length = 461
Score = 82.7 bits (201), Expect = 8e-15
Identities = 99/426 (23%), Positives = 180/426 (42%), Gaps = 42/426 (9%)
Query: 34 ALARAHAKLGNIPEESARVIS---ERANTKWVKLERVKEIEAEIHHDIMAVVKALSEVCG 90
A A+A + I EE I E+ +W + V E E H A + L+E+ G
Sbjct: 45 AYAKALCQKNVISEEELNSILKGLEQIQREWNSGQFVLEPSDEDVHT--ANERRLTEIIG 102
Query: 91 EHGKYVHLGATSNDIIDTANALLIKESLAIVEKDLKELRSILKELAKKHIDTVCIGRTHG 150
+ +H G + ND + T L + + VE + L + A+ ID + G TH
Sbjct: 103 DVAGKLHTGRSRNDQVTTDLRLWLCRKIKEVEVYVINLLKVFTNRAEMEIDVIMSGYTHL 162
Query: 151 QHAVPTTYGMKFALWLDEIQRHIERLQQLKDRVLVGKMRGAVGTAASFGDKAFEIEK-LV 209
Q A P + + + RL+QL R V ++ G A K F +++ +
Sbjct: 163 QRAQPVRWSHFLMSHALPLLGDLGRLRQLYTR--VSQLTAGAGALAG---KPFNVDREFL 217
Query: 210 MEDLGLKPARIT--NQIIQRDVYAELMFFLALVASTLDKMALEIRNLQRTE--ILEVSEP 265
++LG + + N + RD E MF+ +V + + A ++ +E + +S+
Sbjct: 218 PKELGFEGIIMNSMNAVGDRDFVIEFMFWAGMVMLHISRFAEDLIIYSSSEFGFVTLSDA 277
Query: 266 FGEKQVGSSTMPHKRNPIRTEKVCGLARVLYSNVIPALL---NNPLWHERDLTNSSVERV 322
+ GSS MP K+NP E + G + + ++I ++ P + +DL ++
Sbjct: 278 Y---STGSSIMPQKKNPDSLELLRGKSGRVLGDMIGLMITVKGTPTTYNKDLQE---DKE 331
Query: 323 ILPESFVLLDEMLKVMKKVLKGLEFFPENIKRNLYLTKNLIMAEPLMLKLAEKGMGRQEA 382
L ++F + + L+++ V+ L P I + LT +L+ + L L KG+ ++
Sbjct: 332 PLFDAFKTVSDSLQILTGVVSTLTINPTKIAES--LTPDLLASTDLAEYLVRKGLPFRQT 389
Query: 383 HELVRQLAMKAFKEGRDLLEVVRKNEEAMKYLTENDLEGLKPENYIGKAREIVENVVNYV 442
H + + + + + L+ +DL+ L P E V V NY
Sbjct: 390 HHI-----------SGSAVRMAEERNTTLDKLSVSDLQSLHP-----LFDEDVSKVFNYE 433
Query: 443 EEMERR 448
E +E+R
Sbjct: 434 ESVEKR 439
>gb|AAF43427.1|AF233374_1 (AF233374) argininosuccinate lyase [Volvox carteri]
Length = 482
Score = 82.7 bits (201), Expect = 8e-15
Identities = 101/434 (23%), Positives = 184/434 (42%), Gaps = 42/434 (9%)
Query: 16 RRVWEEENKLQKLLDVEAALARA----HAKLGNIPEESARVISERANTKWVKLERVKEIE 71
+R+W E+ K + ALA+A H + +I + ++V E + +V VK +
Sbjct: 44 KRLWAEDIKGSQAY--AKALAKAGILTHVEAASIVDGLSKVAEEWQSGVFV----VKPGD 97
Query: 72 AEIHHDIMAVVKALSEVCGEHGKYVHLGATSNDIIDTANALLIKESLAIVEKDLKELRSI 131
+IH A + L+E+ G G +H G + ND + T L + +A++ +L+EL +
Sbjct: 98 EDIH---TANERRLTELIGAVGGKLHTGRSRNDQVATDYRLWLTHQVAVMRSELQELIRV 154
Query: 132 LKELAKKHIDTVCIGRTHGQHAVPTTYGMKFALWLDEIQRHIERLQQLKDRVLVGKMRGA 191
+ ++ ++ + G TH Q+A+ + QR RL+ L RV +
Sbjct: 155 AADRSEAEVEVLMPGFTHLQNAMAVRWSHWLMCHCAAWQRDDMRLRDLTPRVATLPL--- 211
Query: 192 VGTAASFGDKAFEIEKLVMEDLGLKPARITNQ---IIQRDVYAELMFFLALVASTLDKMA 248
G+ A G+ + + +LG N + RD E +F +L+ + L + A
Sbjct: 212 -GSGALAGNPFRVDRQFIARELGFVGGVCPNSMDAVSDRDFVIETVFACSLLCTHLSRWA 270
Query: 249 LEIRNLQRTEILEVSEPFGEKQ------VGSSTMPHKRNPIRTEKVCGLARVLYSN---V 299
++ I+ S PFG Q GSS MP K+NP E + G + N V
Sbjct: 271 EDL-------IIYSSGPFGYVQCSDAYATGSSLMPQKKNPDALELIRGKGGRIQGNLTGV 323
Query: 300 IPALLNNPLWHERDLTNSSVERVILPESFVLLDEMLKVMKKVLKGLEFFPENIKRNLYLT 359
+ L P + +D +L ++ + +++++ VL ++ PE +K L
Sbjct: 324 LAVLKGTPTTYNKDFQEC---WELLFDTVDTVHDVVRIATGVLSTIKIRPEKMKSGLSAD 380
Query: 360 KNLIMAEPLMLKLAEKGMGRQEAHELVRQLAMKAFKEGRDLLEVVRKNEEAMKYLTENDL 419
++A L L KG+ +E H L A G L E+ ++ + + L D+
Sbjct: 381 ---MLATDLAEYLVRKGVPFRETHHLSGAAVKMAEDRGVGLSELRVEDLQTIHPLFTEDV 437
Query: 420 EGLKPENYIGKARE 433
+ N + R+
Sbjct: 438 VAVWDFNRSAEMRD 451
>sp|P40369|ARLY_SCHPO ARGININOSUCCINATE LYASE (ARGINOSUCCINASE) (ASAL)
>gi|4910|emb|CAA44915.1| (X63262) argininosuccinate
lyase [Schizosaccharomyces pombe]
Length = 461
Score = 81.9 bits (199), Expect = 1e-14
Identities = 99/426 (23%), Positives = 180/426 (42%), Gaps = 42/426 (9%)
Query: 34 ALARAHAKLGNIPEESARVIS---ERANTKWVKLERVKEIEAEIHHDIMAVVKALSEVCG 90
A A+A + I EE I E+ +W + V E E H A + L+E+ G
Sbjct: 45 AYAKALCQKNVISEEELNSILKGLEQIQREWNSGQFVLEPSDEDVHT--ANERRLTEIIG 102
Query: 91 EHGKYVHLGATSNDIIDTANALLIKESLAIVEKDLKELRSILKELAKKHIDTVCIGRTHG 150
+ +H G + ND + T L + + VE + L + A+ ID + G TH
Sbjct: 103 DVAGKLHTGRSRNDQVTTDLRLWLCRKIKEVEVYVINLLKVFTNRAEMEIDVIMSGYTHL 162
Query: 151 QHAVPTTYGMKFALWLDEIQRHIERLQQLKDRVLVGKMRGAVGTAASFGDKAFEIEK-LV 209
Q A P + + + RL+QL R V ++ G A K F +++ +
Sbjct: 163 QRAQPVRWSHFLMSHALPLLGDLGRLRQLYTR--VSQLTAGAGALAG---KPFNVDREFL 217
Query: 210 MEDLGLKPARIT--NQIIQRDVYAELMFFLALVASTLDKMALEIRNLQRTE--ILEVSEP 265
++LG + + N + RD E MF+ +V + + A ++ +E + +S+
Sbjct: 218 PKELGSEGIIMNSMNAVGDRDFVIEFMFWAGMVMLHISRFAEDLIIYSSSEFGFVTLSDA 277
Query: 266 FGEKQVGSSTMPHKRNPIRTEKVCGLARVLYSNVIPALL---NNPLWHERDLTNSSVERV 322
+ GSS MP K+NP E + G + + ++I ++ P + +DL ++
Sbjct: 278 Y---STGSSIMPQKKNPDSLELLRGKSGRVLGDMIGLMITVKGTPTTYNKDLQE---DKE 331
Query: 323 ILPESFVLLDEMLKVMKKVLKGLEFFPENIKRNLYLTKNLIMAEPLMLKLAEKGMGRQEA 382
L ++F + + L+++ V+ L P I + LT +L+ + L L KG+ ++
Sbjct: 332 PLFDAFKTVSDSLQILTGVVSTLTINPTKIAES--LTPDLLASTDLAEYLVRKGLPFRQT 389
Query: 383 HELVRQLAMKAFKEGRDLLEVVRKNEEAMKYLTENDLEGLKPENYIGKAREIVENVVNYV 442
H + + + + + L+ +DL+ L P E V V NY
Sbjct: 390 HHI-----------SGSAVRMAEERNTTLDKLSVSDLQSLHP-----LFDEDVSKVFNYE 433
Query: 443 EEMERR 448
E +E+R
Sbjct: 434 ESVEKR 439
>prf||2105196A argininosuccinate lyase [Rana catesbeiana]
Length = 467
Score = 80.4 bits (195), Expect = 4e-14
Identities = 97/410 (23%), Positives = 184/410 (44%), Gaps = 27/410 (6%)
Query: 34 ALARAHAKLGNI-PEESARVIS--ERANTKWVKLERV-KEIEAEIHHDIMAVVKALSEVC 89
A +A K G + P E +++ ++ + +W K V + + +IH A + L E+
Sbjct: 44 AYVKALEKAGLVSPTEMEHILTGLDQIHEEWSKGTFVLTKADEDIH---TANERRLKELI 100
Query: 90 GEHGKYVHLGATSNDIIDTANALLIKESLAIVEKDLKELRSILKELAKKHIDTVCIGRTH 149
GE +H G + ND + T L +++S + + L L + + A ID + G TH
Sbjct: 101 GEPAGKLHTGRSRNDQVVTDMRLWLRDSCSALHLHLTRLIRTMVDRAAIEIDILFPGYTH 160
Query: 150 GQHAVPTTYGMKFALWLDEIQRHIERLQQLKDRVLVGKM-RGAVGTAASFGDKAFEIEKL 208
Q A P + + R ERL +L+ R+ V + GA+ D+ ++L
Sbjct: 161 NQRAQPIRWSHWILSHAVALCRDAERLGELRKRINVLPLGSGAIAGNPLGVDRELLRKEL 220
Query: 209 VMEDLGLKPARITNQIIQRDVYAELMFFLALVASTLDKMA--LEIRNLQRTEILEVSEPF 266
+ + L T+ +RD AE +F+ +L + L KM+ L I + + + +S+ +
Sbjct: 221 EFDSVSLNSMDATS---ERDFIAEFLFWASLCMTHLSKMSEDLIIYSTKEFSFVTLSDSY 277
Query: 267 GEKQVGSSTMPHKRNPIRTEKVCGLARVLY---SNVIPALLNNPLWHERDLTNSSVERVI 323
GSS MP K+NP E + A ++ S + L P + +DL ++
Sbjct: 278 ---STGSSLMPQKKNPDSLELIRSKAGRVFGRCSGFLMTLKGLPSTYNKDLQE---DKEA 331
Query: 324 LPESFVLLDEMLKVMKKVLKGLEFFPENIKRNLYLTKNLIMAEPLMLKLAEKGMGRQEAH 383
+ + + + +L+V V+ L+ E +++ L ++A + L KGM ++AH
Sbjct: 332 MFDVYDTVCAVLQVASGVISTLQINKEGMEKAL---SPDMLATDIAYYLVRKGMPFRQAH 388
Query: 384 ELVRQLAMKAFKEGRDLLEVVRKNEEAMKYLTENDLEGLKPENYIGKARE 433
L ++ A +G L ++ ++ +++ L ND+ K NY +
Sbjct: 389 GLSGKVVQLAETKGIALNKLSLEDLKSISPLFSNDVS--KVWNYTNSVEQ 436
>sp|P73257|ARLY_SYNY3 ARGININOSUCCINATE LYASE (ARGINOSUCCINASE) (ASAL)
>gi|7437146|pir||S77437 argininosuccinate lyase (EC
4.3.2.1) - Synechocystis sp. (strain PCC 6803)
>gi|1652362|dbj|BAA17284.1| (D90905) L-argininosuccinate
lyase [Synechocystis sp.]
Length = 461
Score = 80.4 bits (195), Expect = 4e-14
Identities = 83/361 (22%), Positives = 165/361 (44%), Gaps = 27/361 (7%)
Query: 80 AVVKALSEVCGEHGKYVHLGATSNDIIDTANALLIKESLAIVEKDLKELRSILKELAKKH 139
AV + L+E+ G+ GK +H + ND + T L ++ + + + L++ +++L +LA+ +
Sbjct: 88 AVERRLTELVGDVGKKLHTARSRNDQVGTDVRLYLRAQIDDIRQRLRDFQAVLLQLAETN 147
Query: 140 IDTVCIGRTHGQHAVPTTYGMKFALWLDEIQRHIERLQQLKDRVLVGKMRGAVGTAASFG 199
++T+ G TH Q A P + + QR +RL +++ R V + +F
Sbjct: 148 VETLIPGYTHLQRAQPVSLAHHLLAYFQMAQRDWQRLGEIRARTNVSPLGSGALAGTTFP 207
Query: 200 -DKAFEIEKLVMEDLGLKPARITNQIIQRDVYAELMFFLALVASTLDKMALEIRNLQRTE 258
D+ + E L + A + + RD E + +L+ L +++ E+
Sbjct: 208 IDRHYSAELLGFAGV---YANSLDGVSDRDFAIEFLNAASLIMVHLSRLSEEM------- 257
Query: 259 ILEVSEPFG------EKQVGSSTMPHKRNPIRTEKVCGLA-RVL--YSNVIPALLNNPLW 309
IL S+ F GSS MP K+NP E + G A RV+ ++ + PL
Sbjct: 258 ILWASQEFSFISLTDSCATGSSIMPQKKNPDVPELIRGKAGRVMGHLQGMLVLMKGLPLA 317
Query: 310 HERDLTNSSVERVILPESFVLLDEMLKVMKKVL-KGLEFFPENIKRNLYLTKNLIMAEPL 368
+ +DL ++ L ++ + L+ M +L +G+ F E + + ++ A +
Sbjct: 318 YNKDLQE---DKEALFDAVKTVQVSLEAMTILLDEGIVFRQERLAE--AVAEDFSNATDV 372
Query: 369 MLKLAEKGMGRQEAHELVRQLAMKAFKEGRDLLEVVRKNEEAMKYLTENDL-EGLKPENY 427
LA KG+ +EA+ LV ++ + G+ L ++ +A+ E D+ + + P+
Sbjct: 373 ADYLAAKGVPFREAYNLVGKVVKTSLAAGKLLKDLTLAEWQALHPAFEEDIYQAITPQQV 432
Query: 428 I 428
+
Sbjct: 433 V 433
>emb|CAB76090.1| (AL157956) argininosuccinate lyase [Streptomyces coelicolor A3(2)]
Length = 475
Score = 80.4 bits (195), Expect = 4e-14
Identities = 97/395 (24%), Positives = 171/395 (42%), Gaps = 34/395 (8%)
Query: 27 KLLDVEAALARAHAKLGNIPEESARVISERANTKWVK-LERVKEIEAE-------IHHDI 78
+L + A +RAHA++ + +A +++E T+ + L+R++ A+ D+
Sbjct: 35 RLAPYDIAGSRAHARVLH----AAGLLTEDELTRMIAGLDRLEADVADGSFTGTIADEDV 90
Query: 79 -MAVVKALSEVCG-EHGKYVHLGATSNDIIDTANALLIKESLAIVEKDLKELRSILKELA 136
A+ + L E G + G + G + ND + T + +++ V + +L+ L LA
Sbjct: 91 HTALERGLLERLGPDLGGKLRAGRSRNDQVATLFRMYLRDHARTVGSLIADLQDALVGLA 150
Query: 137 KKHIDTVCIGRTHGQHAVPTTYGMKFALWLDEIQRHIERLQQLKDRVLVGKMRGAVGTAA 196
+ H D GRTH QHA P + + R ERL+Q R V G+ A
Sbjct: 151 EAHPDVAMPGRTHLQHAQPVLFAHHVLAHAQALGRDAERLRQWDARTAV----SPYGSGA 206
Query: 197 SFGDKAFEIEKLVMEDLGLKPARITNQI---IQRDVYAELMFFLALVASTLDKMALE--I 251
G + V DLG + + N I RD AE F A++ + ++A E I
Sbjct: 207 LAGSSLGLDPEAVARDLGFEHGSVGNSIDGTASRDFVAEFAFITAMIGVNVSRIAEEIII 266
Query: 252 RNLQRTEILEVSEPFGEKQVGSSTMPHKRNPIRTEKVCGLARVLYSN---VIPALLNNPL 308
N + + + + F GSS MP K+NP E G + L N ++ L PL
Sbjct: 267 WNTKEFSFVTLHDAF---STGSSIMPQKKNPDIAELARGKSGRLIGNLTGLMATLKALPL 323
Query: 309 WHERDLTNSSVERVILPESFVLLDEMLKVMKKVLKGLEFFPENIKRNLYLTKNLIMAEPL 368
+ RDL ++ + +S L+ +L ++ L E ++ +A +
Sbjct: 324 AYNRDLQE---DKEPVFDSIDQLEVLLPAFTGMMATLTVHRERMEE--LAPAGFSLATDI 378
Query: 369 MLKLAEKGMGRQEAHELVRQLAMKAFKEGRDLLEV 403
L ++G+ + AHE+ + A +G++L E+
Sbjct: 379 AEWLVKQGVPFRVAHEVAGECVKVAEADGKELDEL 413
>sp|P02521|CRD1_CHICK DELTA CRYSTALLIN I >gi|68371|pir||CYCHD delta-1-crystallin -
chicken >gi|211672|gb|AAA48726.1| (M10806) delta-1
crystallin [Gallus gallus] >gi|313705|emb|CAA26144.1|
(X02222) delta-crystallin [Gallus gallus]
Length = 466
Score = 80.0 bits (194), Expect = 5e-14
Identities = 92/373 (24%), Positives = 169/373 (44%), Gaps = 33/373 (8%)
Query: 26 QKLLDVEAALARAHAKLGNIPEESARVISERANTKWVK-LERVKE-------IEAEIHHD 77
Q+L +V+ + A+AK E A ++++ K + LE++ E + + D
Sbjct: 32 QRLTEVDIQASMAYAKA----LEKASILTKTELEKILSGLEKISEESSKGVLVMTQSDED 87
Query: 78 IM-AVVKALSEVCGEHGKYVHLGATSNDIIDTANALLIKESLAIVEKDLKELRSILKELA 136
I A+ + L E+ G+ + G + N+ + T LL+K S++++ L +L L E A
Sbjct: 88 IQTAIERRLKELIGDIAGKLQTGRSRNEQVVTDLKLLLKSSISVISTHLLQLIKTLVERA 147
Query: 137 KKHIDTVCIGRTHGQHAVPTTYGMKFALWLDEIQRHIERLQQLKDRVLVGKMRGAVGTAA 196
ID + G TH Q A+P + + R ERL ++K R+ V + G+ A
Sbjct: 148 AIEIDIIMPGYTHLQKALPIRWSQFLLSHAVALTRDSERLGEVKKRITVLPL----GSGA 203
Query: 197 SFGDKAFEIEKLVMEDLGLKPARIT--NQIIQRDVYAELMFFLALVASTLDKMALEIRNL 254
G+ +L+ +L + + + I +RD EL+ L+ L K+A ++
Sbjct: 204 LAGNPLEIDRELLRSELDMTSITLNSIDAISERDFVVELISVATLLMIHLSKLAEDLIIF 263
Query: 255 QRTE--ILEVSEPFGEKQVGSSTMPHKRNPIRTEKVCGLARVLYSN---VIPALLNNPLW 309
TE + +S+ + GSS +P K+NP E + A ++ ++ L P
Sbjct: 264 STTEFGFVTLSDAY---STGSSLLPQKKNPDSLELIRSKAGRVFGRLAAILMVLKGIPST 320
Query: 310 HERDLTNSSVERVILPESFVLLDEMLKVMKKVLKGLEFFPENIKRNLYLTKNLIMAEPLM 369
+DL ++ + + L +L+V V+ L+ EN+++ LT L+ + L
Sbjct: 321 FSKDLQE---DKEAVLDVVDTLTAVLQVATGVISTLQVNKENMEK--ALTPELLSTD-LA 374
Query: 370 LKLAEKGMGRQEA 382
L L KGM ++A
Sbjct: 375 LYLVRKGMPIRQA 387
>emb|CAA25260.1| (X00626) delta-crystallin [Gallus gallus] >gi|459706|gb|AAA51616.1|
(K03257) delta-1 crystallin [Gallus gallus]
Length = 447
Score = 79.2 bits (192), Expect = 9e-14
Identities = 92/371 (24%), Positives = 166/371 (43%), Gaps = 29/371 (7%)
Query: 26 QKLLDVEAALARAHAKLGNIPEESARVISERANTKWVK-LERVKE-------IEAEIHHD 77
Q+L +V+ + A+AK E A ++++ K + LE++ E + + D
Sbjct: 32 QRLTEVDIQASMAYAKA----LEKASILTKTELEKILSGLEKISEESSKGVLVMTQSDED 87
Query: 78 IM-AVVKALSEVCGEHGKYVHLGATSNDIIDTANALLIKESLAIVEKDLKELRSILKELA 136
I A+ + L E+ G+ + G + N+ + T LL+K S +++ L +L L E A
Sbjct: 88 IQTAIERRLKELIGDIAGKLQTGRSRNEQVLTDLKLLLKSSTSVISTHLLQLIKTLVERA 147
Query: 137 KKHIDTVCIGRTHGQHAVPTTYGMKFALWLDEIQRHIERLQQLKDRVLVGKMRGAVGTAA 196
ID + G TH Q A+P + + R ERL ++K R+ V + G+ A
Sbjct: 148 AIEIDIIMPGYTHLQKALPIRWSQFLLSHAVALTRDSERLGEVKKRITVLPL----GSGA 203
Query: 197 SFGDKAFEIEKLVMEDLGLKPARIT--NQIIQRDVYAELMFFLALVASTLDKMALEIRNL 254
G+ +L+ +L + + + I +RD EL+ L+ L K+A ++
Sbjct: 204 LAGNPLEIDRELLRSELDMTSITLNSIDAISERDFVVELISVATLLMIHLSKLAEDLIIF 263
Query: 255 QRTEILEVSEPFGEKQVGSSTMPHKRNPIRTEKVCGLARVLYSN---VIPALLNNPLWHE 311
TE V+ F GSS +P K+NP E + A ++ ++ L P
Sbjct: 264 STTEFGFVT-LFDAYSTGSSLLPQKKNPDSLELIRSKAGRVFGRLAAILMVLKGIPSTFS 322
Query: 312 RDLTNSSVERVILPESFVLLDEMLKVMKKVLKGLEFFPENIKRNLYLTKNLIMAEPLMLK 371
+DL ++ + + L +L+ +V+ L+ EN+++ LT L+ + L L
Sbjct: 323 KDLQE---DKEAVLDVVDTLTAVLQAATEVISTLQVNKENMEK--ALTPELLSTD-LALY 376
Query: 372 LAEKGMGRQEA 382
L KGM ++A
Sbjct: 377 LVRKGMPIRQA 387
>sp|P51464|ARLY_RANCA ARGININOSUCCINATE LYASE (ARGINOSUCCINASE) (ASAL)
>gi|944979|dbj|BAA07421.1| (D38302) argininosuccinate
lyase [Rana catesbeiana]
Length = 467
Score = 79.2 bits (192), Expect = 9e-14
Identities = 97/410 (23%), Positives = 184/410 (44%), Gaps = 27/410 (6%)
Query: 34 ALARAHAKLGNI-PEESARVIS--ERANTKWVKLERV-KEIEAEIHHDIMAVVKALSEVC 89
A +A K G + P E +++ ++ + +W K V + + +IH A + L E+
Sbjct: 44 AYVKALEKAGLVSPTEMEHILTGLDQIHEEWSKGTFVLTKADEDIH---TANERRLKELI 100
Query: 90 GEHGKYVHLGATSNDIIDTANALLIKESLAIVEKDLKELRSILKELAKKHIDTVCIGRTH 149
GE +H G + ND + T L +++S + + L L + + A ID + G TH
Sbjct: 101 GEPAGKLHTGRSRNDQVVTDMRLWLRDSCSALHLHLTRLIRTMVDRAAIEIDILFPGYTH 160
Query: 150 GQHAVPTTYGMKFALWLDEIQRHIERLQQLKDRVLVGKM-RGAVGTAASFGDKAFEIEKL 208
Q A P + + R ERL +L+ R+ V + GA+ D+ ++L
Sbjct: 161 MQRAQPIRWSHWILSHAVALCRDAERLGELRKRINVLPLGSGAIAGNPLGVDRELLRKEL 220
Query: 209 VMEDLGLKPARITNQIIQRDVYAELMFFLALVASTLDKMA--LEIRNLQRTEILEVSEPF 266
+ + L T+ +RD AE +F+ +L + L KM+ L I + + + +S+ +
Sbjct: 221 EFDSVSLNSMDATS---ERDFIAEFLFWASLCMTHLSKMSEDLIIYSTKEFSFVTLSDSY 277
Query: 267 GEKQVGSSTMPHKRNPIRTEKVCGLARVLY---SNVIPALLNNPLWHERDLTNSSVERVI 323
GSS MP K+NP E + A ++ S + L P + +DL ++
Sbjct: 278 ---STGSSLMPQKKNPDSLELIRSKAGRVFGRCSGFLMTLKGLPSTYNKDLQE---DKEA 331
Query: 324 LPESFVLLDEMLKVMKKVLKGLEFFPENIKRNLYLTKNLIMAEPLMLKLAEKGMGRQEAH 383
+ + + + +L+V V+ L+ E +++ L ++A + L KGM ++AH
Sbjct: 332 MFDVYDTVCAVLQVASGVISTLQINKEGMEKAL---SPDMLATDIAYYLVRKGMPFRQAH 388
Query: 384 ELVRQLAMKAFKEGRDLLEVVRKNEEAMKYLTENDLEGLKPENYIGKARE 433
L ++ A +G L ++ ++ +++ L ND+ K NY +
Sbjct: 389 GLSGKVVQLAETKGIALNKLSLEDLKSISPLFSNDVS--KVWNYTNSVEQ 436
>pir||S52133 argininosuccinate lyase (EC 4.3.2.1) - bullfrog
Length = 467
Score = 79.2 bits (192), Expect = 9e-14
Identities = 97/410 (23%), Positives = 184/410 (44%), Gaps = 27/410 (6%)
Query: 34 ALARAHAKLGNI-PEESARVIS--ERANTKWVKLERV-KEIEAEIHHDIMAVVKALSEVC 89
A +A K G + P E +++ ++ + +W K V + + +IH A + L E+
Sbjct: 44 AYVKALEKAGLVSPTEMEHILTGLDQIHEEWSKGTFVLTKADEDIH---TANERRLKELI 100
Query: 90 GEHGKYVHLGATSNDIIDTANALLIKESLAIVEKDLKELRSILKELAKKHIDTVCIGRTH 149
GE +H G + ND + T L +++S + + L L + + A ID + G TH
Sbjct: 101 GEPAGKLHTGRSRNDQVVTDMRLWLRDSCSALHLHLTRLIRTMVDRAAIEIDILFPGYTH 160
Query: 150 GQHAVPTTYGMKFALWLDEIQRHIERLQQLKDRVLVGKM-RGAVGTAASFGDKAFEIEKL 208
Q A P + + R ERL +L+ R+ V + GA+ D+ ++L
Sbjct: 161 MQRAQPIRWSHWILSHAVALCRDAERLGELRKRINVLPLGSGAIAGNPLGVDRELLRKEL 220
Query: 209 VMEDLGLKPARITNQIIQRDVYAELMFFLALVASTLDKMA--LEIRNLQRTEILEVSEPF 266
+ + L T+ +RD AE +F+ +L + L KM+ L I + + + +S+ +
Sbjct: 221 EFDSVSLNSMDATS---ERDFIAEFLFWASLCMTHLSKMSEDLIIYSTKEFSFVTLSDSY 277
Query: 267 GEKQVGSSTMPHKRNPIRTEKVCGLARVLY---SNVIPALLNNPLWHERDLTNSSVERVI 323
GSS MP K+NP E + A ++ S + L P + +DL ++
Sbjct: 278 ---STGSSLMPQKKNPDSLELIRSKAGRVFGRCSGFLMTLKGLPSTYNKDLQE---DKEA 331
Query: 324 LPESFVLLDEMLKVMKKVLKGLEFFPENIKRNLYLTKNLIMAEPLMLKLAEKGMGRQEAH 383
+ + + + +L+V V+ L+ E +++ L ++A + L KGM ++AH
Sbjct: 332 MFDVYDTVCAVLQVASGVISTLQINKEGMEKAL---SPDMLATDIAYYLVRKGMPFRQAH 388
Query: 384 ELVRQLAMKAFKEGRDLLEVVRKNEEAMKYLTENDLEGLKPENYIGKARE 433
L ++ A +G L ++ ++ +++ L ND+ K NY +
Sbjct: 389 GLSGKVVQLAETKGIALNKLSLEDLKSISPLFSNDVS--KVWNYTNSVEQ 436
>gb|AAA48728.1| (J00843) delta-crystallin mRNA [Gallus gallus]
Length = 447
Score = 78.4 bits (190), Expect = 1e-13
Identities = 91/373 (24%), Positives = 168/373 (44%), Gaps = 33/373 (8%)
Query: 26 QKLLDVEAALARAHAKLGNIPEESARVISERANTKWVK-LERVKE-------IEAEIHHD 77
Q+L +V+ + A+AK E A ++++ K + LE++ E + + D
Sbjct: 32 QRLTEVDIQASMAYAKA----LEKASILTKTELEKILSGLEKISEESSKGVLVMTQSDED 87
Query: 78 IM-AVVKALSEVCGEHGKYVHLGATSNDIIDTANALLIKESLAIVEKDLKELRSILKELA 136
I A+ + L E+ G+ + G + N+ + T LL+K S++++ L +L L E A
Sbjct: 88 IQTAIERRLKELIGDIAGKLQTGRSRNEQVVTDLKLLLKSSISVISTHLLQLIKTLVERA 147
Query: 137 KKHIDTVCIGRTHGQHAVPTTYGMKFALWLDEIQRHIERLQQLKDRVLVGKMRGAVGTAA 196
ID + G TH Q A+P + + R ERL ++K R+ V + G+ A
Sbjct: 148 AIEIDIIMPGYTHLQKALPIRWSQFLLSHAVALTRDSERLGEVKKRITVLPL----GSGA 203
Query: 197 SFGDKAFEIEKLVMEDLGLKPARIT--NQIIQRDVYAELMFFLALVASTLDKMALEIRNL 254
G+ +L+ +L + + + I +RD EL+ L+ L K+A ++
Sbjct: 204 LAGNPLEIDRELLRSELDMTSITLNSIDAISERDFVVELISVATLLMIHLSKLAEDLIIF 263
Query: 255 QRTE--ILEVSEPFGEKQVGSSTMPHKRNPIRTEKVCGLARVLYSN---VIPALLNNPLW 309
TE + +S+ + GSS +P K+NP E + A ++ ++ L P
Sbjct: 264 STTEFGFVTLSDAY---STGSSLLPQKKNPDSLELIRSKAGRVFGRLAAILMVLKGIPST 320
Query: 310 HERDLTNSSVERVILPESFVLLDEMLKVMKKVLKGLEFFPENIKRNLYLTKNLIMAEPLM 369
+DL ++ + + L +L+ V+ L+ EN+++ LT L+ + L
Sbjct: 321 FSKDLQE---DKEAVLDVVDTLTAVLQAATGVISTLQVNKENMEK--ALTPELLSTD-LA 374
Query: 370 LKLAEKGMGRQEA 382
L L KGM ++A
Sbjct: 375 LYLVRKGMPIRQA 387
>pir||UFBSC8 fumarate hydratase (EC 4.2.1.2) - Bacillus subtilis
>gi|39844|emb|CAA25849.1| (X01701) fumarase [Bacillus
subtilis]
Length = 462
Score = 78.0 bits (189), Expect = 2e-13
Identities = 99/347 (28%), Positives = 157/347 (44%), Gaps = 34/347 (9%)
Query: 96 VHLGATSNDIIDTANALLIKESLAIVEK---DLKELRSILKELAKKHIDTVCIGRTHGQH 152
V+ +SND TA + + LA+ E+ L +LR+ L E AK + D V IGRTH Q
Sbjct: 132 VNRSQSSNDTFPTA--MHVAAVLAVYEQLVPALDQLRNTLDEKAKAYNDIVKIGRTHLQD 189
Query: 153 AVPTTYGMKFALWLDEIQRHIERLQQLKDRVLVGKMRG-AVGTAAS----FGD-KAFEIE 206
A P T G + + W+ + R E + + D++ + G AVGT + FG+ + EI
Sbjct: 190 ATPLTLGQEISGWVHMLDRSKEMILEATDKMRALAIGGTAVGTGINAHPEFGELVSEEIT 249
Query: 207 KLVMEDLGLKPARITNQIIQRDVYAELMFFLALVASTLDKMALEIRNL---QRTEILEVS 263
KL + P + + + D L +A+ L K+A ++R L R I E+
Sbjct: 250 KLTGQTFSSSPNKF-HALTSHDEITYAHGALKALAADLMKIANDVRWLASGPRCGIGEIV 308
Query: 264 EPFGEKQVGSSTMPHKRNPIRTEKVCGL-ARVLYSNVIPALLNNPLWHERDLTNSSVERV 322
P E + GSS MP K NP ++E + + A+++ ++ + E ++ +
Sbjct: 309 IP--ENEPGSSIMPGKVNPTQSEALTMIAAQIMGNDATIGFAASQGNFELNVFKPVIIYN 366
Query: 323 ILPESFVLLDEMLKVMKKVLKGLEFFPENIKRNLYLTKNLIMAEPLMLKLAEKGMGRQEA 382
L +L D M K G+E E I+ NL + LML A +
Sbjct: 367 FLQSVQLLSDGMNSFHDKCAVGIEPNKETIQENL--------SNSLMLVTA---LNPHIG 415
Query: 383 HELVRQLAMKAFKEGRDLLEVVRKNEEAMKYLTENDL-EGLKPENYI 428
+E ++A A KEG L E K ++ LTE E +KPE+ +
Sbjct: 416 YENAAKIAKLAHKEGLTLKEAALK----LELLTEEQFNEMVKPEDMV 458
>sp|P07343|FUMH_BACSU FUMARATE HYDRATASE, CLASS-II (FUMARASE) >gi|2635801|emb|CAB15294.1|
(Z99120) fumarate hydratase [Bacillus subtilis]
>gi|2832825|emb|CAA11749.1| (AJ223978) fumarase protein,
CitG [Bacillus subtilis]
Length = 462
Score = 78.0 bits (189), Expect = 2e-13
Identities = 99/347 (28%), Positives = 157/347 (44%), Gaps = 34/347 (9%)
Query: 96 VHLGATSNDIIDTANALLIKESLAIVEK---DLKELRSILKELAKKHIDTVCIGRTHGQH 152
V+ +SND TA + + LA+ E+ L +LR+ L E AK + D V IGRTH Q
Sbjct: 132 VNRSQSSNDTFPTA--MHVAAVLAVYEQLVPALDQLRNTLDEKAKAYNDIVKIGRTHLQD 189
Query: 153 AVPTTYGMKFALWLDEIQRHIERLQQLKDRVLVGKMRG-AVGTAAS----FGD-KAFEIE 206
A P T G + + W+ + R E + + D++ + G AVGT + FG+ + EI
Sbjct: 190 ATPLTLGQEISGWVHMLDRSKEMILEATDKMRALAIGGTAVGTGINAHPEFGELVSEEIT 249
Query: 207 KLVMEDLGLKPARITNQIIQRDVYAELMFFLALVASTLDKMALEIRNL---QRTEILEVS 263
KL + P + + + D L +A+ L K+A ++R L R I E+
Sbjct: 250 KLTGQTFSSSPNKF-HALTSHDEITYAHGALKALAADLMKIANDVRWLASGPRCGIGEIV 308
Query: 264 EPFGEKQVGSSTMPHKRNPIRTEKVCGL-ARVLYSNVIPALLNNPLWHERDLTNSSVERV 322
P E + GSS MP K NP ++E + + A+++ ++ + E ++ +
Sbjct: 309 IP--ENEPGSSIMPGKVNPTQSEALTMIAAQIMGNDATIGFAASQGNFELNVFKPVIIYN 366
Query: 323 ILPESFVLLDEMLKVMKKVLKGLEFFPENIKRNLYLTKNLIMAEPLMLKLAEKGMGRQEA 382
L +L D M K G+E E I+ NL + LML A +
Sbjct: 367 FLQSVQLLSDGMNSFHDKCAVGIEPNKETIQENL--------SNSLMLVTA---LNPHIG 415
Query: 383 HELVRQLAMKAFKEGRDLLEVVRKNEEAMKYLTENDL-EGLKPENYI 428
+E ++A A KEG L E K ++ LTE E +KPE+ +
Sbjct: 416 YENAAKIAKLAHKEGLTLKEAALK----LELLTEEQFNEMVKPEDMV 458
>pir||T39679 argininosuccinate lyase - fission yeast (Schizosaccharomyces pombe)
>gi|3850092|emb|CAA21919.1| (AL033389) argininosuccinate
lyase [Schizosaccharomyces pombe]
Length = 461
Score = 78.0 bits (189), Expect = 2e-13
Identities = 99/425 (23%), Positives = 178/425 (41%), Gaps = 41/425 (9%)
Query: 34 ALARAHAKLGNIPEESARVIS---ERANTKWVKLERVKEIEAEIHHDIMAVVKALSEVCG 90
A A+A + I EE I E+ +W + V E E H A + L+E+ G
Sbjct: 45 AYAKALCQKNVISEEELNSILKGLEQIQREWNSGQFVLEPSDEDVHT--ANERRLTEIIG 102
Query: 91 EHGKYVHLGATSNDIIDTANALLIKESLAIVEKDLKELRSILKELAKKHIDTVCIGRTHG 150
+ +H G + ND + T L + + VE + L + A+ ID + G TH
Sbjct: 103 DVAGKLHTGRSRNDQVTTDLRLWLCRKIKEVEVYVINLLKVFTNRAEMEIDVIMSGYTHL 162
Query: 151 QHAVPTTYGMKFALWLDEIQRHIERLQQLKDRVLVGKMRGAVGTAASFGDKAFEIEKLVM 210
Q A P + + + RL+QL RV + +G A G+ + +
Sbjct: 163 QRAQPVRWSHFLMSHALPLLGDLGRLRQLYTRV----SQLPLGAGALAGNPFNVDREFLR 218
Query: 211 EDLGLKPARIT--NQIIQRDVYAELMFFLALVASTLDKMALEIRNLQRTE--ILEVSEPF 266
++LG + + N + RD E MF+ +V + + A ++ +E + +S+ +
Sbjct: 219 KELGFEGIIMNSMNAVGDRDFVIEFMFWAGMVMLHISRFAEDLIIYSSSEFGFVTLSDAY 278
Query: 267 GEKQVGSSTMPHKRNPIRTEKVCGLARVLYSNVIPALL---NNPLWHERDLTNSSVERVI 323
GSS MP K+NP E + G + + ++I ++ P + +DL ++
Sbjct: 279 ---STGSSIMPQKKNPDSLELLRGKSGRVLGDMIGLMITVKGTPTTYNKDLQE---DKEP 332
Query: 324 LPESFVLLDEMLKVMKKVLKGLEFFPENIKRNLYLTKNLIMAEPLMLKLAEKGMGRQEAH 383
L ++F + + L+++ V+ L P I + LT +L +A L L KG+ ++ H
Sbjct: 333 LFDAFKTVSDSLQILTGVVSTLTINPTKIAES--LTPDL-LATDLAEYLVRKGLPFRQTH 389
Query: 384 ELVRQLAMKAFKEGRDLLEVVRKNEEAMKYLTENDLEGLKPENYIGKAREIVENVVNYVE 443
+ + + + + L+ +DL+ L P E V V NY E
Sbjct: 390 HI-----------SGSAVRMAEERNTTLDKLSVSDLQSLHP-----LFDEDVSKVFNYEE 433
Query: 444 EMERR 448
+E+R
Sbjct: 434 SVEKR 438
>gi|11024648 argininosuccinate lyase [Rattus norvegicus]
>gi|114160|sp|P20673|ARLY_RAT ARGININOSUCCINATE LYASE
(ARGINOSUCCINASE) (ASAL) >gi|68367|pir||WZRTRS
argininosuccinate lyase (EC 4.3.2.1) - rat
>gi|203008|gb|AAA40766.1| (M22697) argininosuccinate
lyase [Rattus norvegicus] >gi|551296|dbj|BAA05859.1|
(D28501) argininosuccinate lyase [Rattus norvegicus]
>gi|360236|prf||1402279A argininosuccinate lyase [Rattus
norvegicus]
Length = 461
Score = 77.6 bits (188), Expect = 3e-13
Identities = 81/343 (23%), Positives = 157/343 (45%), Gaps = 18/343 (5%)
Query: 83 KALSEVCGEHGKYVHLGATSNDIIDTANALLIKESLAIVEKDLKELRSILKELAKKHIDT 142
+ L E+ GE +H G + ND + T L ++++ + + LK L + + A+ +
Sbjct: 94 RRLKELIGEAAGKLHTGRSRNDQVVTDLRLWMRQTYSKLSTFLKVLIEAMVDRAEAECEV 153
Query: 143 VCIGRTHGQHAVPTTYGMKFALWLDEIQRHIERLQQLKDRVLVGKM-RGAVGTAASFGDK 201
+ G TH Q A P + + R +ERL++++ R+ V + GA+ D+
Sbjct: 154 LFPGYTHLQRAQPIRWSHWILSHAVALTRDLERLKEVQKRINVLPLGSGAIAGNPLGVDR 213
Query: 202 AFEIEKLVMEDLGLKPARITNQIIQRDVYAELMFFLALVASTLDKMA--LEIRNLQRTEI 259
F +L + L T+ +RD AE +F+ +L + L +MA L + +
Sbjct: 214 EFLCAELNFGAITLNSMDATS---ERDFVAEFLFWASLCMTHLSRMAEDLILYGTKEFNF 270
Query: 260 LEVSEPFGEKQVGSSTMPHKRNPIRTEKVCGLARVLY---SNVIPALLNNPLWHERDLTN 316
+++S+ + GSS MP K+NP E + AR ++ + ++ L P + +DL
Sbjct: 271 VQLSDAY---STGSSLMPQKKNPDSLELIRSKARRVFGRCAGLLMTLKGLPSTYNKDLQE 327
Query: 317 SSVERVILPESFVLLDEMLKVMKKVLKGLEFFPENIKRNLYLTKNLIMAEPLMLKLAEKG 376
++ + E + +L+V V+ L+ EN+ + L ++A L L KG
Sbjct: 328 ---DKEAVFEVSDTMTAVLQVATGVISTLQIHRENMAQAL---SPDMLATDLAYYLVRKG 381
Query: 377 MGRQEAHELVRQLAMKAFKEGRDLLEVVRKNEEAMKYLTENDL 419
M ++AHE + + A +G L ++ + + + L +D+
Sbjct: 382 MPFRQAHEASGKAVVVAEMKGVALNQLSLQELQTVSPLFSSDV 424
>pir||B75250 fumarate hydratase - Deinococcus radiodurans (strain R1)
>gi|6460457|gb|AAF12164.1|AE002092_2 (AE002092) fumarate
hydratase [Deinococcus radiodurans]
Length = 464
Score = 77.3 bits (187), Expect = 3e-13
Identities = 103/414 (24%), Positives = 179/414 (42%), Gaps = 51/414 (12%)
Query: 36 ARAHAKLGNIPEESARVISERANT----------KWVKLERVKEIEAEIHHDIMAVVKAL 85
A+A+A+LG +P + A +I + A+ V + ++ ++ + + +A+
Sbjct: 58 AQANAELGELPADVADLIVKAADEVIAGKLDEHFPLVVFQTGSGTQSNMNANEVISNRAI 117
Query: 86 SEVCGEHGK--------YVHLGATSNDIIDTA-NALLIKESLAIVEKDLKELRSILKELA 136
GE G +V+ G +SND TA + ++ E + + +LR L A
Sbjct: 118 ELAGGEMGSKKPVHPNDHVNRGQSSNDTFPTAMHIAVVLELNERLYGAVGKLRDTLHAKA 177
Query: 137 KKHIDTVCIGRTHGQHAVPTTYGMKFALWLDEIQRHIERLQQLKDRVLVGKMRG-AVGTA 195
+++ D V +GRTH Q A P T G + W+ ++ + ++ + +L + G AVGT
Sbjct: 178 EQYKDLVKVGRTHLQDATPITLGQEIGGWVAQLDYALSEVKHAGEGLLDLAIGGTAVGTG 237
Query: 196 AS----FGDKAFEIEKLVMEDLGLKPARITNQ---IIQRDVYAELMFFLALVASTLDKMA 248
+ FGD A K E+ G N+ + D + L +A L KMA
Sbjct: 238 LNAHPKFGDLA---AKKYEEETGYHFRSAENKFAALSAHDALVQTSAALRTLAGALMKMA 294
Query: 249 LEIRNL---QRTEILEVSEPFGEKQVGSSTMPHKRNPIRTEKVCGLA-RVLYSNVIPALL 304
++R L R I E++ P E + GSS MP K NP ++E + +A RV ++ A
Sbjct: 295 NDVRWLASGPRNGIGEITIP--ENEPGSSIMPGKVNPTQSEAMTMVATRVFGNDATVAFA 352
Query: 305 NNPLWHERDLTNSSVERVILPESFVLLDEMLKVMKKVLKGLEFFPENIKRNLYLTKNLIM 364
+ + ++ + +L ++ D L G++ IK N L KNL+
Sbjct: 353 GSQGNFQLNVFKPVMVHAVLESIRLISDACLAFNDHCAVGIQPNEAKIKEN--LDKNLMQ 410
Query: 365 AEPLMLKLAEKGMGRQEAHELVRQLAMKAFKEGRDLLEVVRKNEEAMKYLTEND 418
L R ++ +A KA KEG L + A+ Y+TE++
Sbjct: 411 VTAL---------NRHIGYDKAAAIAKKAHKEGTSLKDAAL----ALGYVTEDE 451
>dbj|BAB05145.1| (AP001512) aspartate ammonia-lyase [Bacillus halodurans]
Length = 471
Score = 77.3 bits (187), Expect = 3e-13
Identities = 82/342 (23%), Positives = 153/342 (43%), Gaps = 38/342 (11%)
Query: 83 KALSEVCGEHGKY--------VHLGATSNDIIDTANALLIKESLAIVEKDLKELRSILKE 134
+A+ + GE G+Y V++ ++ND TA + + + L++L + +KE
Sbjct: 113 RAIEILGGEKGEYLRVSPNTHVNMAQSTNDAFPTAIHIACLYLAKGLIQSLEDLIAAIKE 172
Query: 135 LAKKHIDTVCIGRTHGQHAVPTTYGMKFALWLDEIQRHIERLQQLKDRVLVGKMRGAVGT 194
++ D + +GRTH Q AVP G +F + + R + R++ D + M GA
Sbjct: 173 KEQQFDDVLKMGRTHLQDAVPIRMGQEFGAYRRVLTRDLGRIRSSIDHMHEINM-GATAV 231
Query: 195 AASFGDKAFEIEKLV--MEDLGLKPARITNQII----QRDVYAELMFFLALVASTLDKMA 248
K +EK+V + D+ P R ++ D Y EL L ++A L KMA
Sbjct: 232 GTGLNAKPEYMEKVVAYLSDITEFPFRHAADLVDATQNTDAYTELSSALKILAINLSKMA 291
Query: 249 LEIRNLQ---RTEILEVSEPFGEKQVGSSTMPHKRNPIRTEKVCGLARVLYSNVIPALLN 305
+IR + RT + E++ P +Q GSS MP K NP+ E + ++ + N
Sbjct: 292 NDIRLMSSGPRTGLNEINLP--PRQPGSSIMPGKVNPVMAEVINQISFQVIGND------ 343
Query: 306 NPLWHERDLTNSSVERVILPESFVLLDEMLKVMKKVLKGLEFFP----ENIKRNLYLTKN 361
H L + + + + VL+ +L+ + + G++ F E + N+ K
Sbjct: 344 ----HTISLASEAGQLELNVMEPVLVFNLLQSLSILQNGMKVFRQHAIEGMTANVERCKE 399
Query: 362 LIMAEPLMLKLAEKGMGRQEAHELVRQLAMKAFKEGRDLLEV 403
++ + ++ +G +E ++A +A + GR + E+
Sbjct: 400 MVESSVGIITAINPHVG----YETASRIAKEAIQTGRPVREI 437
>sp|P57159|ARLY_BUCAI ARGININOSUCCINATE LYASE (ARGINOSUCCINASE) (ASAL)
>gi|10038739|dbj|BAB12774.1| (AP001118)
argininosuccinate lyase [Buchnera sp. APS]
Length = 459
Score = 76.9 bits (186), Expect = 4e-13
Identities = 82/350 (23%), Positives = 159/350 (45%), Gaps = 27/350 (7%)
Query: 81 VVKALSEVCGEHGKYVHLGATSNDIIDTANALLIKESLAIVEKDLKELRSILKELAKKHI 140
+ + L + G GK +H G + ND I T L ++ + ++ +++ EL+ A+ +
Sbjct: 88 IEEKLIQKIGILGKKLHTGRSRNDQITTDLKLWCRKKIHLLLENIIELQKTFILSAESNH 147
Query: 141 DTVCIGRTHGQHAVPTTYGMKFALWLDEIQRHIERLQQLKDRVLVGKMRGAVGTAASFGD 200
+ + G TH Q A P T+ +++ +R RL+ + R+ V + G+AA G
Sbjct: 148 NIIMPGYTHLQRAQPITFSYWCLAYVEMFRRDFSRLKDVLKRLNVSPL----GSAALSG- 202
Query: 201 KAFEIEKLVMEDLGLKPA------RITNQIIQRDVYAELMFFLALVASTLDKMALEI--R 252
A++I + E+L L + + RD EL+ ++ L + + +I
Sbjct: 203 TAWKINR---EELALSMGFDSATNNALDTVSDRDYVVELLSSASISMMHLSRFSEDIIFF 259
Query: 253 NLQRTEILEVSEPFGEKQVGSSTMPHKRNPIRTEKV---CGLARVLYSNVIPALLNNPLW 309
N + +E+S+ GSS MP K+NP E + CG +++ L + PL
Sbjct: 260 NSGEADFIELSDTITS---GSSLMPQKKNPDALELIRAKCGRVHGSLISILVILKSLPLS 316
Query: 310 HERDLTNSSVERVILPESFVLLDEMLKVMKKVLKGLEFFPENIKRNLYLTKNLIMAEPLM 369
+ +D+ ++ L +S ++ L + VLK ++ E+ ++ + A +
Sbjct: 317 YNKDMQE---DKEGLFDSIKTWNDCLCMAILVLKNMQIKNESCRK--AAEEGYSNATEIA 371
Query: 370 LKLAEKGMGRQEAHELVRQLAMKAFKEGRDLLEVVRKNEEAMKYLTENDL 419
L +KG+ +EAH + QL ++A E + L E+ + L +ND+
Sbjct: 372 DYLVKKGIAFREAHNISGQLVLRAISEKKSLNELKLSVFQMYSNLIKNDI 421
>gi|8393358 fumarate hydratase [Rattus norvegicus]
>gi|120605|sp|P14408|FUMH_RAT FUMARATE HYDRATASE,
MITOCHONDRIAL PRECURSOR (FUMARASE) >gi|68295|pir||UFRT
fumarate hydratase (EC 4.2.1.2) precursor, mitochondrial
- rat >gi|204188|gb|AAA41177.1| (J04473) fumarase
precursor (EC 4.2.1.2) [Rattus norvegicus]
Length = 507
Score = 76.5 bits (185), Expect = 6e-13
Identities = 90/347 (25%), Positives = 155/347 (43%), Gaps = 30/347 (8%)
Query: 95 YVHLGATSNDIIDTANALLIK-ESLAIVEKDLKELRSILKELAKKHIDTVCIGRTHGQHA 153
+V+ +SND TA + E ++ L++L L +K+ + IGRTH Q A
Sbjct: 177 HVNKSQSSNDTFPTAMHIAAALEVHQVLLPGLQKLHDALSAKSKEFAQVIKIGRTHTQDA 236
Query: 154 VPTTYGMKFALWLDEIQRHIERLQQLKDRVLVGKMRG-AVGTAAS----FGDK-AFEIEK 207
VP T G +F+ ++ ++Q +ER++ R+ G AVGT + F +K A ++
Sbjct: 237 VPLTLGQEFSGYVQQVQYAMERIKAAMPRIYELAAGGTAVGTGLNTRIGFAEKVAAKVAA 296
Query: 208 LVMEDLGLKPARITNQIIQRDVYAELMFFLALVASTLDKMALEIRNL---QRTEILEVSE 264
L P + + D EL + A +L K+A +IR L R+ + E+
Sbjct: 297 LTGLPFVTAPNKF-EALAAHDALVELSGAMNTTACSLMKIANDIRFLGSGPRSGLGELIL 355
Query: 265 PFGEKQVGSSTMPHKRNPIRTEKVCGLARVLYSNVIPALLNNPLWH-ERDLTNSSVERVI 323
P E + GSS MP K NP + E + +A + N + + H E ++ + + +
Sbjct: 356 P--ENEPGSSIMPGKVNPTQCEAMTMVAAQVMGNHVAVTVGGSNGHFELNVFKPMMIKNV 413
Query: 324 LPESFVLLDEMLKVMKKVLKGLEFFPENIKRNLYLTKNLIMAEPLMLKLAEKGMGRQEAH 383
L + +L D + + + G++ E I N +M E LML A + +
Sbjct: 414 LHSARLLGDASVSFTENCVVGIQANTERI--------NKLMNESLMLVTA---LNPHIGY 462
Query: 384 ELVRQLAMKAFKEGRDLLEVVRKNEEAMKYLTENDL-EGLKPENYIG 429
+ ++A A K G L +K + YLT E +KP++ +G
Sbjct: 463 DKAAKIAKTAHKNGSTL----KKTAIELGYLTAEQFDEWVKPKDMLG 505
>prf||1709138A fumarase [Rattus norvegicus]
Length = 507
Score = 76.5 bits (185), Expect = 6e-13
Identities = 90/347 (25%), Positives = 155/347 (43%), Gaps = 30/347 (8%)
Query: 95 YVHLGATSNDIIDTANALLIK-ESLAIVEKDLKELRSILKELAKKHIDTVCIGRTHGQHA 153
+V+ +SND TA + E ++ L++L L +K+ + IGRTH Q A
Sbjct: 177 HVNKSQSSNDTFPTAMHIAAALEVHQVLLPGLQKLHDALSAKSKEFAQVIKIGRTHTQDA 236
Query: 154 VPTTYGMKFALWLDEIQRHIERLQQLKDRVLVGKMRG-AVGTAAS----FGDK-AFEIEK 207
VP T G +F+ ++ ++Q +ER++ R+ G AVGT + F +K A ++
Sbjct: 237 VPLTLGQQFSGYVQQVQYAMERIKAAMPRIYELAAGGTAVGTGLNTRIGFAEKVAAKVAA 296
Query: 208 LVMEDLGLKPARITNQIIQRDVYAELMFFLALVASTLDKMALEIRNL---QRTEILEVSE 264
L P + + D EL + A +L K+A +IR L R+ + E+
Sbjct: 297 LTGLPFVTAPNKF-EALAAHDALVELSGAMNTTACSLMKIANDIRFLGSGPRSGLGELIL 355
Query: 265 PFGEKQVGSSTMPHKRNPIRTEKVCGLARVLYSNVIPALLNNPLWH-ERDLTNSSVERVI 323
P E + GSS MP K NP + E + +A + N + + H E ++ + + +
Sbjct: 356 P--ENEPGSSIMPGKVNPTQCEAMTMVAAQVMGNHVAVTVGGSNGHFELNVFKPMMIKNV 413
Query: 324 LPESFVLLDEMLKVMKKVLKGLEFFPENIKRNLYLTKNLIMAEPLMLKLAEKGMGRQEAH 383
L + +L D + + + G++ E I N +M E LML A + +
Sbjct: 414 LHSARLLGDASVSFTENCVVGIQANTERI--------NKLMNESLMLVTA---LNPHIGY 462
Query: 384 ELVRQLAMKAFKEGRDLLEVVRKNEEAMKYLTENDL-EGLKPENYIG 429
+ ++A A K G L +K + YLT E +KP++ +G
Sbjct: 463 DKAAKIAKTAHKNGSTL----KKTAIELGYLTAEQFDEWVKPKDMLG 505
>sp|P11447|ARLY_ECOLI ARGININOSUCCINATE LYASE (ARGINOSUCCINASE) (ASAL)
>gi|7437145|pir||C65203 argininosuccinate lyase (EC
4.3.2.1) - Escherichia coli >gi|396307|gb|AAC43066.1|
(U00006) argininosuccinate lyase [Escherichia coli]
>gi|1790398|gb|AAC76942.1| (AE000470) argininosuccinate
lyase [Escherichia coli K12]
Length = 457
Score = 76.5 bits (185), Expect = 6e-13
Identities = 98/400 (24%), Positives = 176/400 (43%), Gaps = 30/400 (7%)
Query: 28 LLDVEAALARAHAKLGNIPEESARVISERANTKWVKLERVKEIEAEIHHDIMAVVKALSE 87
L+ V A A+L EE+ V+ E + +++ E +AE H V L +
Sbjct: 44 LVTVGVLTAEEQAQL----EEALNVLLEDVRAR---PQQILESDAEDIHSW--VEGKLID 94
Query: 88 VCGEHGKYVHLGATSNDIIDTANALLIKESLAIVEKDLKELRSILKELAKKHIDTVCIGR 147
G+ GK +H G + ND + T L K++++ + ++L+S L E A+ + D V G
Sbjct: 95 KVGQLGKKLHTGRSRNDQVATDLKLWCKDTVSELLTANRQLQSALVETAQNNQDAVMPGY 154
Query: 148 THGQHAVPTTYGMKFALWLDEIQRHIERLQQLKDRVLVGKMRGAVGTAASFGDKAFEIEK 207
TH Q A P T+ +++ + R RLQ R+ V + G A G A+EI++
Sbjct: 155 THLQRAQPVTFAHWCLAYVEMLARDESRLQDALKRLDVSPL----GCGALAG-TAYEIDR 209
Query: 208 LVMED-LGLKPA--RITNQIIQRDVYAELMFFLALVASTLDKMA--LEIRNLQRTEILEV 262
+ LG A + + RD EL+ A+ L + A L N +E+
Sbjct: 210 EQLAGWLGFASATRNSLDSVSDRDHVLELLSAAAIGMVHLSRFAEDLIFFNTGEAGFVEL 269
Query: 263 SEPFGEKQVGSSTMPHKRNPIRTEKV---CGLARVLYSNVIPALLNNPLWHERDLTNSSV 319
S+ GSS MP K+NP E + CG + + ++ L PL + +D+
Sbjct: 270 SD---RVTSGSSLMPQKKNPDALELIRGKCGRVQGALTGMMMTLKGLPLAYNKDMQE--- 323
Query: 320 ERVILPESFVLLDEMLKVMKKVLKGLEFFPENIKRNLYLTKNLIMAEPLMLKLAEKGMGR 379
++ L ++ + L + VL G++ + + + A L L KG+
Sbjct: 324 DKEGLFDALDTWLDCLHMAALVLDGIQV--KRPRCQEAAQQGYANATELADYLVAKGVPF 381
Query: 380 QEAHELVRQLAMKAFKEGRDLLEVVRKNEEAMKYLTENDL 419
+EAH +V + ++A ++G+ L ++ + + + D+
Sbjct: 382 REAHHIVGEAVVEAIRQGKPLEDLPLSELQKFSQVIDEDV 421
>pir||T43727 fumarate hydratase (EC 4.2.1.2) [imported] - Thermus aquaticus
(subsp. thermophilus) >gi|3062847|dbj|BAA25700.1|
(AB010884) class II fumarase [Thermus thermophilus]
Length = 466
Score = 76.5 bits (185), Expect = 6e-13
Identities = 110/458 (24%), Positives = 199/458 (43%), Gaps = 55/458 (12%)
Query: 7 DYRYGSEEMRRVWEEENKLQKLLDVEAALARAHAKLGNIPEESARVISERANT----KW- 61
++R+G++ R E L + A ARA+ +LG +PEE A+ I + A KW
Sbjct: 31 NFRFGTDRFRMPLEIIRAYGML---KKAAARANLELGELPEEIAKAIIQAAEEVVQGKWD 87
Query: 62 -----VKLERVKEIEAEIHHDIMAVVKALSEVCGEH--GKYVH------LGATSNDIIDT 108
V + + ++ + + +A SE+ G+ KYVH G +SND T
Sbjct: 88 DHFPLVVFQTGSGTQTNMNVNEVIANRA-SEILGKPLGSKYVHPNDHVNRGQSSNDTFPT 146
Query: 109 ANALLIKESLAIVEKDLKELRSILKELAKK---HIDTVCIGRTHGQHAVPTTYGMKFALW 165
A + + +LA+ ++ + +++ K V +GRTH AVP T G + W
Sbjct: 147 A--MYVAVALALHQRLYPAVEGLIRTFTAKAQAFDQIVKVGRTHLMDAVPITLGQEIGSW 204
Query: 166 LDEIQRHIERLQQLKDRVLVGKMRG-AVGTAASFGDKAFE-IEKLVMEDLGLKPARITNQ 223
+++ + +++++ + + G AVGT + + E + K + E+ GL P R+
Sbjct: 205 AAQLKTTLAAVKEMEKGLYNLAIGGTAVGTGLNGHPRFGELVAKYLAEETGL-PFRVAEN 263
Query: 224 ----IIQRDVYAELMFFLALVASTLDKMALEIRNLQR---TEILEVSEPFGEKQVGSSTM 276
+ D +M + +A L K+ ++R L I E++ P E GSS M
Sbjct: 264 RFAALAAHDELVNVMGAIRTLAGALMKIGNDVRWLASGPYAGIGEITIPANEP--GSSIM 321
Query: 277 PHKRNPIRTEKVCGLARVLYSN-VIPALLNNPLWHERDLTNSSVERVILPESFVLLDEML 335
P K NP + E + + +Y N A + + ++ + L +L D +
Sbjct: 322 PGKVNPTQVEALTMVVVRVYGNDHTVAFAGSQGNFQLNVYKPVMAYSTLESINLLADAVA 381
Query: 336 KVMKKVLKGLEFFPENIKRNLYLTKNLIMAEPLMLKLAEKGMGRQEAHELVRQLAMKAFK 395
+ +G+E E I+ +L KN P++ K +G +A E+V+ KA K
Sbjct: 382 SFDAHLAQGIEPNLERIEE--HLQKN-----PMLATALNKAIGYDKAAEIVK----KALK 430
Query: 396 EGRDLLEVVRKNEEAMKYLTENDLEGLKPENYIGKARE 433
E + L + + + YLTE + + + + K E
Sbjct: 431 EKKTLKQAALE----LGYLTEEEFDRIVVPMRLAKPHE 464
>sp|O34858|ARLY_BACSU ARGININOSUCCINATE LYASE (ARGINOSUCCINASE) (ASAL)
>gi|7437147|pir||C69589 argininosuccinate lyase argH -
Bacillus subtilis >gi|2293243|gb|AAC00321.1| (AF008220)
arginine succinate lyase [Bacillus subtilis]
>gi|2635409|emb|CAB14904.1| (Z99118) argininosuccinate
lyase [Bacillus subtilis] >gi|2635428|emb|CAB14922.1|
(Z99119) argininosuccinate lyase [Bacillus subtilis]
Length = 461
Score = 75.7 bits (183), Expect = 1e-12
Identities = 97/410 (23%), Positives = 169/410 (40%), Gaps = 42/410 (10%)
Query: 30 DVEAALARAHA--KLGNIPEESARVISERANTKWVKLER-VKEIEAEIHHDIMAVVKALS 86
D+ +LA A K G + E I E NT K E E + + + K L
Sbjct: 34 DITGSLAHAAMLKKCGILTAEEELKIREGLNTLLQKAEEGALEFSVDYEDIHLNIEKMLI 93
Query: 87 EVCGEHGKYVHLGATSNDIIDTANALLIKESLAIVEKDLKELRSILKELAKKHIDTVCIG 146
+ G G +H G + ND + T L +K + + + ++ +S L E A+ +++T+ G
Sbjct: 94 DEIGPLGGKLHTGRSRNDQVATDMHLYLKNHVGHIIELIEAFQSALIEKAEANVETILPG 153
Query: 147 RTHGQHAVPTTYGMKFALWLDEIQRHIERLQQLKDRVLVGKMRGAVGTAASFGDKAFEIE 206
TH Q A P ++ + ++R ER Q R+ + +G A G F I+
Sbjct: 154 YTHLQRAQPISFAHHLLAYFWMLERDKERFQDSMKRI----NKSPLGCGALAG-TTFPID 208
Query: 207 KLVMEDLGLKPARITNQ---IIQRDVYAELMFFLALVASTLDKMALEI--RNLQRTEILE 261
+ +L A N + RD E + +++ L + + EI Q + +E
Sbjct: 209 RDYSAELLGFDAIYENSLDGVSDRDFILEFLSNSSMLMMHLSRFSEEIILWCSQEFKFIE 268
Query: 262 VSEPFGEKQVGSSTMPHKRNPIRTEKVCGLARVLYSNVI---PALLNNPLWHERDLTNSS 318
+ + + GSS MP K+NP E + G +Y +++ + PL + +DL
Sbjct: 269 LDDTYA---TGSSMMPQKKNPDMAELIRGKTGRVYGDMMGLFTIMKGLPLAYNKDLQEDK 325
Query: 319 VERVILPESFVLLDEMLKVMKKVLKGLEFFPENIKRNLYLTKNLIM---------AEPLM 369
+ M +K V L+ F I + + + K+++ A L
Sbjct: 326 -------------EGMFDTVKTVEGSLQIFTGMI-QTMTVNKDVMKQATKQDFSNATELA 371
Query: 370 LKLAEKGMGRQEAHELVRQLAMKAFKEGRDLLEVVRKNEEAMKYLTENDL 419
LA+KGM +EAHE+V +L + G L ++ + L E D+
Sbjct: 372 DYLAKKGMPFREAHEVVGKLVYTCIERGIYLSDMPFGEFQQASTLFEEDI 421
>emb|CAB88663.1| (AJ277474) argininosuccinate lyase [Agaricus bisporus]
Length = 402
Score = 75.7 bits (183), Expect = 1e-12
Identities = 80/333 (24%), Positives = 146/333 (43%), Gaps = 35/333 (10%)
Query: 66 RVKEIEAEIHHDIMAVVKALSEVCGEHGKYVHLGATSNDIIDTANALLIKESLAIVEKDL 125
+VKE + +IH A + L+E+ G G +H G + ND + T L + + + VE+ L
Sbjct: 21 QVKEDDEDIH---TANERRLTELIGPLGGKLHTGRSRNDQVATDMRLWLLDEVRDVEQGL 77
Query: 126 KELRSILKELAKKHIDTVCIGRTHGQHAVPTTYGMKFALWLDEIQRHIERLQQLKDRVLV 185
+ L ++ E A + D + G TH Q P + + +ERLQQL R+ V
Sbjct: 78 RALIRVMIERADQEKDYLLPGYTHLQRGQPIRWSHLLLSHAFSFRSDLERLQQLIPRISV 137
Query: 186 GKMRGAVGTAASFGDKAFEIEKLVMEDLGLKPARITN--QIIQRDVYAELMFFLALVAST 243
+ G A G+ + + ++LG + + + RD E + + +L
Sbjct: 138 LPL----GCGALAGNPFAVDREFLAKELGFQHVAENSLWGVGDRDFIVEFLQWSSLTMVH 193
Query: 244 LDKMA--LEIRNLQRTEILEVSEPFGEKQVGSSTMPHKRNPIRTEKVCGLARVLYSNV-- 299
+ +MA L I + + +S+ + GSS MP K+NP E + G + ++ N+
Sbjct: 194 ISRMAEDLIIYSTAEFGFVTLSDAY---STGSSIMPQKKNPDSLELLRGKSGRIFGNMAG 250
Query: 300 -------IPALLNNPLWHERDLTNSSVERVILPESFVLLDEMLKVMKKVLKGLEFFPENI 352
+P+ N L +++ +V+ V LK+ + V+ L PE +
Sbjct: 251 FLMTYKGLPSTYNKDLQEDKEPLFDAVDNV---------SASLKIAEGVIATLTVHPERM 301
Query: 353 KRNLYLTKNLIMAEPLMLKLAEKGMGRQEAHEL 385
++ L + ++A L L KG+ +E H +
Sbjct: 302 RQALTMD---VLATDLADYLVRKGVPFRETHHI 331
>dbj|BAA03088.1| (D13978) argininosuccinate lyase [Rattus sp.]
>gi|226538|prf||1601424A argininosuccinate lyase [Rattus
norvegicus]
Length = 461
Score = 74.9 bits (181), Expect = 2e-12
Identities = 80/343 (23%), Positives = 156/343 (45%), Gaps = 18/343 (5%)
Query: 83 KALSEVCGEHGKYVHLGATSNDIIDTANALLIKESLAIVEKDLKELRSILKELAKKHIDT 142
+ L E+ GE +H G + ND + T L ++++ + + LK L + + A+ +
Sbjct: 94 RRLKELIGEAAGKLHTGRSRNDQVVTDLRLWMRQTCSKLSTFLKVLIEAMVDRAEAECEV 153
Query: 143 VCIGRTHGQHAVPTTYGMKFALWLDEIQRHIERLQQLKDRVLVGKM-RGAVGTAASFGDK 201
+ G TH Q A P + + R +ERL++++ R+ V + GA+ D+
Sbjct: 154 LFPGYTHLQRAQPIRWSHWILSHAVALTRDLERLKEVQKRINVLPLGSGAIAGNPLGVDR 213
Query: 202 AFEIEKLVMEDLGLKPARITNQIIQRDVYAELMFFLALVASTLDKMA--LEIRNLQRTEI 259
F +L + L T+ +RD AE +F+ +L + L +MA L + +
Sbjct: 214 EFLCAELNFGAITLNSMDATS---ERDFVAEFLFWASLCMTHLSRMAEDLILYGTKEFNF 270
Query: 260 LEVSEPFGEKQVGSSTMPHKRNPIRTEKVCGLARVLY---SNVIPALLNNPLWHERDLTN 316
+++S+ + GSS MP K+NP E + A ++ + ++ L P + +DL
Sbjct: 271 VQLSDAY---STGSSLMPQKKNPDSLELIRSKAGRVFGRCAGLLMTLKGLPSTYNKDLQE 327
Query: 317 SSVERVILPESFVLLDEMLKVMKKVLKGLEFFPENIKRNLYLTKNLIMAEPLMLKLAEKG 376
++ + E + +L+V V+ L+ EN+ + L ++A L L KG
Sbjct: 328 ---DKEAVFEVSDTMTAVLQVATGVISTLQIHRENMAQAL---SPDMLATDLAYYLVRKG 381
Query: 377 MGRQEAHELVRQLAMKAFKEGRDLLEVVRKNEEAMKYLTENDL 419
M ++AHE + + A +G L ++ + + + L +D+
Sbjct: 382 MPFRQAHEASGKAVVVAEMKGVALNQLSLQELQTVSPLFSSDV 424
>sp|Q9Z660|ARLY_ZYMMO ARGININOSUCCINATE LYASE (ARGINOSUCCINASE) (ASAL)
>gi|4378172|gb|AAD19417.1| (AF102543) arginosuccinate
lyase [Zymomonas mobilis]
Length = 468
Score = 74.9 bits (181), Expect = 2e-12
Identities = 86/376 (22%), Positives = 157/376 (40%), Gaps = 34/376 (9%)
Query: 79 MAVVKALSEVCGEHGKYVHLGATSNDIIDTANALLIKESLAIVEKDLKELRSILKELAKK 138
M K L+++ G +H + ND + T L +++++ +V+K L L++ L A++
Sbjct: 94 MVTEKRLADLIGSAAGRLHTARSRNDQVATDFKLWVRDAIDMVDKGLTALQTALVIRAEE 153
Query: 139 HIDTVCIGRTHGQHAVPTTYGMKFALWLDEIQRHIERLQQLKDRVLVGKMRGAVGTAASF 198
H TV G TH Q A P T G + + I R R + R+ + A F
Sbjct: 154 HAATVMPGFTHLQIAQPITLGHHLMAYYEMISRDRSRFSDGRKRLNQSPLGAAALAGTGF 213
Query: 199 GDKAFEIEKLVMEDLGLKPARITNQIIQRDVYAELMFFLALVASTLDKMALEIRNLQRTE 258
+ K + D A + + RD + + A L ++A EI
Sbjct: 214 NIDRHQTAKALGFD--SPTANSLDSVSDRDFALDYLMSATQTAIHLSRLAEEI------- 264
Query: 259 ILEVSEPFG------EKQVGSSTMPHKRNPIRTEKVCGLARVL---YSNVIPALLNNPLW 309
I+ S+P+G GSS MP KRNP E V G + + + ++ + PL
Sbjct: 265 IIWASQPYGFVSLPDAYSTGSSIMPQKRNPDAAELVRGHSGRIAGCMNALVMTMKGLPLA 324
Query: 310 HERDLTNSSVERVILPESFVLLDEMLKVMKKVLKGLEFFPENIKRNLY--LTKNLIMAEP 367
+ +D+ + ++ + E+ LL + M +++ L F PE +++ + +A+
Sbjct: 325 YSKDMQD---DKPPVFEAHDLLSLAIAAMTGMIETLTFIPEKMRKTAEAGFSTATDLADW 381
Query: 368 LMLKLAEKGMGRQEAHELVRQLAMKAFKEG--------RDLLEVVRKNEEAMKYLTENDL 419
L + + G+ +EAH + A +G DL + + +E++K + D
Sbjct: 382 L---VRQAGIPFREAHHITGSAVRLAETKGIALDALSIEDLKAIDPRIDESVKAVLSVDA 438
Query: 420 EGLKPENYIGKAREIV 435
+Y G A + V
Sbjct: 439 SVASRNSYGGTAPDQV 454
>sp|P22675|ARLY_CHLRE ARGININOSUCCINATE LYASE (ARGINOSUCCINASE) (ASAL)
>gi|7437143|pir||S78597 argininosuccinate lyase (EC
4.3.2.1) - Chlamydomonas reinhardtii
>gi|18112|emb|CAA34615.1| (X16619) argininosuccinate
lyase [Chlamydomonas reinhardtii]
Length = 471
Score = 74.1 bits (179), Expect = 3e-12
Identities = 97/434 (22%), Positives = 178/434 (40%), Gaps = 42/434 (9%)
Query: 16 RRVWEEENKLQKLLDVEAALARAHAKLGNIPEESARVISE---RANTKW-VKLERVKEIE 71
+R+W E+ K + A A+A AK G + + A I E + +W +K +
Sbjct: 37 KRLWAEDIKGSQ------AYAKALAKAGILAHDEAVTIVEGLAKVAEEWKAGAFVIKAGD 90
Query: 72 AEIHHDIMAVVKALSEVCGEHGKYVHLGATSNDIIDTANALLIKESLAIVEKDLKELRSI 131
+IH A + L+E+ G G +H G + ND + T L + + ++ ++ EL +
Sbjct: 91 EDIH---TANERRLTELVGAVGGKLHTGRSRNDQVATDYRLWLVGQVEVMRSEVGELMRV 147
Query: 132 LKELAKKHIDTVCIGRTHGQHAVPTTYGMKFALWLDEIQRHIERLQQLKDRVLVGKMRGA 191
+ ++ ++ + G TH Q+A+ + QR RL+ L RV +
Sbjct: 148 AADRSEAEVEVLMPGFTHLQNAMTVRWSHWLMSHAAAWQRDDMRLRDLLPRVATLPL--- 204
Query: 192 VGTAASFGDKAFEIEKLVMEDLGLKPARITNQ---IIQRDVYAELMFFLALVASTLDKMA 248
G+ A G+ + + ++LG N + RD E +F +L+ L + A
Sbjct: 205 -GSGALAGNPFLVDRQFIAKELGFGGGVCPNSMDAVSDRDFVIETVFAASLLCVHLSRWA 263
Query: 249 LEIRNLQRTEILEVSEPFGEKQ------VGSSTMPHKRNPIRTEKVCGLARVLYSN---V 299
++ I+ S PFG Q GSS MP K+NP E + G + N V
Sbjct: 264 EDL-------IIYSSGPFGYVQCSDAYATGSSLMPQKKNPDALELIRGKGGRVQGNLMGV 316
Query: 300 IPALLNNPLWHERDLTNSSVERVILPESFVLLDEMLKVMKKVLKGLEFFPENIKRNLYLT 359
+ L P + +D +L ++ + +++++ VL L P+ +K L
Sbjct: 317 MAVLKGTPTTYNKDFQEC---WELLFDTVDTVHDVVRIATGVLSTLRIKPDRMKAGLSAD 373
Query: 360 KNLIMAEPLMLKLAEKGMGRQEAHELVRQLAMKAFKEGRDLLEVVRKNEEAMKYLTENDL 419
++A L L KG+ +E H A G L ++ + + + L +D+
Sbjct: 374 ---MLATDLAEYLVRKGVPFRETHHHSGAAVKMAEDRGCTLFDLTVDDLKTIHPLFTDDV 430
Query: 420 EGLKPENYIGKARE 433
+ N + R+
Sbjct: 431 AAVWDFNRSAEMRD 444
>emb|CAA09001.1| (AJ010110) argininosuccinate lyase [Chlamydomonas reinhardtii]
Length = 473
Score = 74.1 bits (179), Expect = 3e-12
Identities = 97/434 (22%), Positives = 178/434 (40%), Gaps = 42/434 (9%)
Query: 16 RRVWEEENKLQKLLDVEAALARAHAKLGNIPEESARVISE---RANTKW-VKLERVKEIE 71
+R+W E+ K + A A+A AK G + + A I E + +W +K +
Sbjct: 39 KRLWAEDIKGSQ------AYAKALAKAGILAHDEAVTIVEGLAKVAEEWKAGAFVIKAGD 92
Query: 72 AEIHHDIMAVVKALSEVCGEHGKYVHLGATSNDIIDTANALLIKESLAIVEKDLKELRSI 131
+IH A + L+E+ G G +H G + ND + T L + + ++ ++ EL +
Sbjct: 93 EDIH---TANERRLTELVGAVGGKLHTGRSRNDQVATDYRLWLVGQVEVMRSEVGELMRV 149
Query: 132 LKELAKKHIDTVCIGRTHGQHAVPTTYGMKFALWLDEIQRHIERLQQLKDRVLVGKMRGA 191
+ ++ ++ + G TH Q+A+ + QR RL+ L RV +
Sbjct: 150 AADRSEAEVEVLMPGFTHLQNAMTVRWSHWLMSHAAAWQRDDMRLRDLLPRVATLPL--- 206
Query: 192 VGTAASFGDKAFEIEKLVMEDLGLKPARITNQ---IIQRDVYAELMFFLALVASTLDKMA 248
G+ A G+ + + ++LG N + RD E +F +L+ L + A
Sbjct: 207 -GSGALAGNPFLVDRQFIAKELGFGGGVCPNSMDAVSDRDFVIETVFAASLLCVHLSRWA 265
Query: 249 LEIRNLQRTEILEVSEPFGEKQ------VGSSTMPHKRNPIRTEKVCGLARVLYSN---V 299
++ I+ S PFG Q GSS MP K+NP E + G + N V
Sbjct: 266 EDL-------IIYSSGPFGYVQCSDAYATGSSLMPQKKNPDALELIRGKGGRVQGNLMGV 318
Query: 300 IPALLNNPLWHERDLTNSSVERVILPESFVLLDEMLKVMKKVLKGLEFFPENIKRNLYLT 359
+ L P + +D +L ++ + +++++ VL L P+ +K L
Sbjct: 319 MAVLKGTPTTYNKDFQEC---WELLFDTVDTVHDVVRIATGVLSTLRIKPDRMKAGLSAD 375
Query: 360 KNLIMAEPLMLKLAEKGMGRQEAHELVRQLAMKAFKEGRDLLEVVRKNEEAMKYLTENDL 419
++A L L KG+ +E H A G L ++ + + + L +D+
Sbjct: 376 ---MLATDLAEYLVRKGVPFRETHHHSGAAVKMAEDRGCTLFDLTVDDLKTIHPLFTDDV 432
Query: 420 EGLKPENYIGKARE 433
+ N + R+
Sbjct: 433 AAVWDFNRSAEMRD 446
>pir||T45269 fumarate hydratase (EC 4.2.1.2) [imported] - Thermus aquaticus
>gi|1311484|dbj|BAA12702.1| (D84646) fumarase [Thermus
aquaticus]
Length = 466
Score = 73.7 bits (178), Expect = 4e-12
Identities = 106/438 (24%), Positives = 187/438 (42%), Gaps = 60/438 (13%)
Query: 31 VEAALARAHAKLGNIPEESARVISERANTKWVKLERVKEIEAEIHHDIMA---------- 80
++ A ARA+ +LG +PEE AR I + A E V + + H ++
Sbjct: 52 LKKAAARANLELGELPEEIARAIIQAA-------EEVIAGKLDDHFPLVVFQTGSGTQTN 104
Query: 81 ------VVKALSEVCGEH--GKYVH------LGATSNDIIDTANALLIKESLAIVEK--- 123
+ SE+ G+ KYVH G +SND TA + + LA+ +
Sbjct: 105 MNVNEVIANRASEILGKPLGSKYVHPNDHVNRGQSSNDTFPTA--MYVATVLALHQHLYP 162
Query: 124 DLKELRSILKELAKKHIDTVCIGRTHGQHAVPTTYGMKFALWLDEIQRHIERLQQLKDRV 183
++ L + +E A+ V +GRTH AVP T G + W +++ + +++ + +
Sbjct: 163 AVEGLIATFEEKARAFDGIVKVGRTHLMDAVPITLGQEVGSWAAQLRNTLAMVKEAEKGL 222
Query: 184 LVGKMRG-AVGTAASFGDKAFE-IEKLVMEDLGLKPARITNQ----IIQRDVYAELMFFL 237
+ G AVGT + + E + + + E+ GL P R+ + D +M L
Sbjct: 223 YNLAIGGTAVGTGLNAHPRFGELVARYLAEETGL-PFRVAENRFAALAAHDELVHVMGAL 281
Query: 238 ALVASTLDKMALEIRNLQRTEILEVSEPF-GEKQVGSSTMPHKRNPIRTEKV-CGLARVL 295
+A L K+ +IR L + E F + GSS MP K NP + E + + RV
Sbjct: 282 RTLAGALMKIGNDIRWLASGPYGGIGEIFIPANEPGSSIMPGKVNPTQVEALPWVVVRVF 341
Query: 296 YSNVIPALLNNPLWHERDLTNSSVERVILPESFVLLDEMLKVMKKVLKGLEFFPENIKRN 355
++ A + + ++ + L +L D + + + +G+E E I+
Sbjct: 342 GNDQAVAFAGSQGNFQLNVYKPVMVDAALESIKLLGDAVASFDQHLAQGIEPNLERIEE- 400
Query: 356 LYLTKNLIMAEPLMLKLAEKGMGRQEAHELVRQLAMKAFKEGRDLLEVVRKNEEAMKYLT 415
+L KN P++ K +G +A E+V+ KA KE + L + + + YLT
Sbjct: 401 -HLNKN-----PMLATALNKAIGYDKAAEIVK----KAIKEKKSLKQAALE----LGYLT 446
Query: 416 ENDLEGLKPENYIGKARE 433
E + + + + K E
Sbjct: 447 EEEFDRIVVPMRLAKPHE 464
>pir||E82989 argininosuccinate lyase PA5263 [imported] - Pseudomonas aeruginosa
(strain PAO1) >gi|9951574|gb|AAG08648.1|AE004938_10
(AE004938) argininosuccinate lyase [Pseudomonas
aeruginosa]
Length = 464
Score = 73.7 bits (178), Expect = 4e-12
Identities = 84/357 (23%), Positives = 147/357 (40%), Gaps = 60/357 (16%)
Query: 73 EIHHDIMAVVKALSEVCGEHGKYVHLGATSNDIIDTANALLIKESLAIVEKDLKELRSIL 132
++H +I A L++ G GK +H G + ND + T L +++ + + ++ L+ L
Sbjct: 88 DVHMNIEA---RLTDRIGVTGKKLHTGRSRNDQVATDIRLWLRDEIDTILAEITRLQEGL 144
Query: 133 KELAKKHIDTVCIGRTHGQHAVPTTYGMKFALWLDEIQRHIERLQQLKDRVLVGKMRGAV 192
LA+ DT+ G TH Q A P T+G W + + R ERL + RV R +
Sbjct: 145 LGLAEAEADTIMPGFTHLQTAQPVTFGHHLLAWFEMLGRDYERLVDCRKRV----NRMPL 200
Query: 193 GTAASFGDKAFEIEKLVMEDLGLKPARITNQIIQRDVYAELMFFLALVASTLD-----KM 247
G+AA G T IQR++ +L+ F A+ ++LD
Sbjct: 201 GSAALAG---------------------TTYPIQREITCQLLGFDAVGGNSLDGVSDRDF 239
Query: 248 ALEIRNLQRTEILEVSEPFGEKQV------------------GSSTMPHKRNPIRTEKVC 289
A+E ++ +S F E+ V GSS MP K+NP E V
Sbjct: 240 AIEFCAAASLAMMHLSR-FSEELVLWTSAQFQFIDLPDRFCTGSSIMPQKKNPDVPELVR 298
Query: 290 GLARVLY---SNVIPALLNNPLWHERDLTNSSVERVILPESFVLLDEMLKVMKKVLKGLE 346
G + ++ + ++ + PL + +D + ++ L ++ L + L+ ++ +
Sbjct: 299 GKSGRVFGALTGLLTLMKGQPLAYNKD---NQEDKEPLFDAADTLRDSLRAFADMVPAIR 355
Query: 347 FFPENIKRNLYLTKNLIMAEPLMLKLAEKGMGRQEAHELVRQLAMKAFKEGRDLLEV 403
P + A L L KG+ ++ HE+V G+DL E+
Sbjct: 356 --PRREIMREAARRGFSTATDLADYLVRKGLPFRDCHEIVGHAVKYGVDSGKDLAEM 410
>sp|P26899|ASPA_BACSU ASPARTATE AMMONIA-LYASE (ASPARTASE) >gi|68299|pir||UFBSD aspartate
ammonia-lyase (EC 4.3.1.1) - Bacillus subtilis
>gi|142518|gb|AAA22244.1| (M63264) L-aspartase [Bacillus
subtilis] >gi|1303988|dbj|BAA12643.1| (D84432) AnsB
[Bacillus subtilis] >gi|2634792|emb|CAB14289.1| (Z99116)
L-aspartase [Bacillus subtilis]
Length = 475
Score = 73.4 bits (177), Expect = 5e-12
Identities = 82/360 (22%), Positives = 159/360 (43%), Gaps = 44/360 (12%)
Query: 83 KALSEVCGEHGKYVHLGATS--------NDIIDTANALLIKESLAIVEKDLKELRSILKE 134
+AL + + G Y+HL + ND+ TA + + L + K ++++ S+ K+
Sbjct: 117 RALEIMGHKKGDYIHLSPNTHVNMSQSQNDVFPTAIHISTLKLLEKLLKTMEDMHSVFKQ 176
Query: 135 LAKKHIDTVCIGRTHGQHAVPTTYGMKFALWLDEIQRHIERLQQLKDRVLVGKMRG-AVG 193
A++ + +GRTH Q AVP G +F + ++R I+R++Q + + M AVG
Sbjct: 177 KAQEFHSVIKMGRTHLQDAVPIRLGQEFEAYSRVLERDIKRIKQSRQHLYEVNMGATAVG 236
Query: 194 TAASFGDKAFEIEKLVMEDLGLKPARITNQII----QRDVYAELMFFLALVASTLDKMAL 249
T + + + + D+ P + ++ D Y E+ L + + K+A
Sbjct: 237 TGLNADPEYIKQVVKHLADISGLPLVGADHLVDATQNTDAYTEVSASLKVCMMNMSKIAN 296
Query: 250 EIRNL---QRTEILEVSEPFGEKQVGSSTMPHKRNPIRTEKVCGLARVLYSNVIPALLNN 306
++R + R + E+S P +Q GSS MP K NP+ E + +A + N +N
Sbjct: 297 DLRLMASGPRAGLAEISLP--ARQPGSSIMPGKVNPVMAELINQIAFQVIGN------DN 348
Query: 307 PLWHERDLTNSSVERVILPESFVLLDEMLKVMKKVLKGLEFFPENIKRNLYLTKNLIMAE 366
+ L + + + + VL+ +L+ + + G F +N K + E
Sbjct: 349 TIC----LASEAGQLELNVMEPVLVFNLLQSISIMNNGFRSFTDN------CLKGIEANE 398
Query: 367 PLMLKLAEKGMGRQEA------HELVRQLAMKAFKEGRDLLEVVRKNEEAMKYLTENDLE 420
M + EK G A +E ++A +A G+ + ++ +++ LTE +L+
Sbjct: 399 KRMKQYVEKSAGVITAVNPHLGYEAAARIAREAIMTGQSVRDLCLQHD----VLTEEELD 454
>sp|P56149|ASPA_HELPY ASPARTATE AMMONIA-LYASE (ASPARTASE) >gi|7436832|pir||A64601
aspartate ammonia-lyase - Helicobacter pylori (strain
26695) >gi|2313768|gb|AAD07709.1| (AE000578) aspartate
ammonia-lyase (aspA) [Helicobacter pylori 26695]
Length = 468
Score = 73.4 bits (177), Expect = 5e-12
Identities = 93/376 (24%), Positives = 166/376 (43%), Gaps = 36/376 (9%)
Query: 67 VKEIEAEIHHDIMAVVKALSEVCGEHGKYVHLGATSNDIIDTANALLIKESLAIVEKDLK 126
+ E+ A + + M K + C + +V+ ++ND +A + I E L+ + +K
Sbjct: 105 MNEVIANLALEYMGHQKGEYQFCHPND-HVNRSQSTNDAYPSALKIAIYERLSNLVAPMK 163
Query: 127 ELRSILKELAKKHIDTVCIGRTHGQHAVPTTYGMKFALWLDEIQRHIERLQQLKDRVLVG 186
LR + AK+ + +GRT Q AVP T G +F + + R IE++ ++ V
Sbjct: 164 ALRDAFAQKAKEFAHVIKMGRTQLQDAVPMTLGQEFETYALMVDRDIEQVLDARNWVREL 223
Query: 187 KMRG-AVGTAA-SFGDKAFEIEKLVMEDLGLKPARITNQIIQ----RDVYAELMFFLALV 240
+ G A+GT S D IEK + E G +P + N +I+ Y ++ L +
Sbjct: 224 NLGGTAIGTGINSHPDYRSLIEKKIQEVTG-RPFVMANNLIEATQSTGAYVQVSGVLKRI 282
Query: 241 ASTLDKMALEIRNLQ---RTEILEVSEPFGEKQVGSSTMPHKRNPIRTEKVCGLARVLYS 297
A L K+ ++R L R + E++ P + Q GSS MP K NP+ E V + +
Sbjct: 283 AVKLSKVCNDLRLLSSGPRAGLNEINLP--KMQPGSSIMPGKVNPVIPEVVNQVCFAVIG 340
Query: 298 NVIPALLNNPLWHERDLTNSSVERVI---LPESFVLLDEMLKVM-KKVLKGLEFFPENIK 353
N + L L + E VI L SFV+L ++ + K ++G+ +
Sbjct: 341 NDLSVAL---AAEGGQLQLNVFEPVIAYKLFHSFVILGRAIETLTTKCVEGITANEKICH 397
Query: 354 RNLYLTKNLIMAEPLMLKLAEKGMGRQEAHELVRQLAMKAFKEGRDLLEVVRKNEEAMKY 413
++ + ++ A + +E +A +A K R + ++ + K
Sbjct: 398 DYVFNSIGIVTA-----------LNPHIGYEKSAMIAKEALKSDRSIYDIALEK----KI 442
Query: 414 LTENDLEGL-KPENYI 428
LT+ L+ + KPEN +
Sbjct: 443 LTKEQLDDIFKPENML 458
>emb|CAA88927.2| (Z49111) argininosuccinate lyase [Streptomyces clavuligerus]
Length = 473
Score = 73.4 bits (177), Expect = 5e-12
Identities = 83/304 (27%), Positives = 128/304 (41%), Gaps = 27/304 (8%)
Query: 27 KLLDVEAALARAHAKLGN-----IPEESARVIS--ERANTKWVKLERVKEIEAEIHHDIM 79
+L + A +RAHA++ N +E R+++ +R W L + ++H
Sbjct: 35 RLAPYDIAGSRAHARVLNRAGLLTEDELTRMLAGLDRWPPMWRTLLHRTIADEDVH---T 91
Query: 80 AVVKALSEVCG-EHGKYVHLGATSNDIIDTANALLIKESLAIVEKDLKELRSILKELAKK 138
A+ + L E G E G + G + ND + T + ++ + + EL+ L LA+
Sbjct: 92 ALERGLLERLGAELGGKLRAGRSRNDQVATLFRMYLRTTPGSSGL-IAELQDALVGLAEA 150
Query: 139 HIDTVCIGRTHGQHAVPTTYGMKFALWLDEIQRHIERLQQLKDRVLVGKMRGAVGTAASF 198
H + GRTH QHA P + + + R ERL+Q R V G+ A
Sbjct: 151 HPEVAMPGRTHLQHAQPVLFAHHVLAHVQALSRDAERLRQWDARTAV----SPYGSGALA 206
Query: 199 GDKAFEIEKLVMEDLGLKPARITNQI---IQRDVYAELMFFLALVASTLDKMALE--IRN 253
G + V DLG + N I RD AE F A+ L ++A E I N
Sbjct: 207 GSSLGLDPEAVAADLGFEGGSAGNSIDGTASRDFVAEFAFITAMAGINLSRLAEEIIIWN 266
Query: 254 LQRTEILEVSEPFGEKQVGSSTMPHKRNPIRTEKVCGLARVLYSN---VIPALLNNPLWH 310
+ + + + F GSS MP K+NP E G + L N ++ L PL +
Sbjct: 267 TKEFSFVTLHDAF---STGSSIMPQKKNPDIAELARGKSGRLIGNLTGLLATLKALPLAY 323
Query: 311 ERDL 314
RDL
Sbjct: 324 NRDL 327
>emb|CAB10698.1| (Z97558) argininosuccinate lyase [Arabidopsis thaliana]
Length = 517
Score = 72.6 bits (175), Expect = 8e-12
Identities = 87/371 (23%), Positives = 164/371 (43%), Gaps = 33/371 (8%)
Query: 73 EIHHDIMAVVKALSEVCGEHGKYVHLGATSNDIIDTANALLIKESLAIVEKDLKELRSIL 132
++H +I A AL+++ GE K +H + ND + T L ++++ + ++ L+ L
Sbjct: 139 DVHMNIEA---ALTDLIGEPAKKLHTARSRNDQVATDFRLWCRDAIDTIIVKIRNLQRAL 195
Query: 133 KELAKKHIDTVCIGRTHGQHAVPTTYGMKFALWLDEIQRHIERLQQLKDRVLVGKMRGAV 192
ELA K+ + G TH Q A P ++++++R R + R+ + GA
Sbjct: 196 VELALKNEALIVPGYTHLQRAQPVLLPHVLLTFVEQLERDAGRYVDCRARLNFSPL-GAC 254
Query: 193 GTAASFGDKAFEIEKLVMED-LGL-KPARIT-NQIIQRDVYAELMFFLALVASTLDKMAL 249
A + I++ + + LG +P R + + + RD E ++ T +
Sbjct: 255 ALAGT----GLPIDRFMTANALGFTEPMRNSIDAVSDRDFVLEFLY-------TNANTGI 303
Query: 250 EIRNLQRTEILEVSEPFG------EKQVGSSTMPHKRNPIRTEKVCGLARVLYSNVIPAL 303
+ L +L SE FG GSS MP K+NP E V G + + +++ L
Sbjct: 304 HLSRLGEEWVLWASEEFGFMTPSDSVSTGSSIMPQKKNPDPMELVRGKSARVIGDLVTVL 363
Query: 304 L---NNPLWHERDLTNSSVERVILPESFVLLDEMLKVMKKVLKGLEFFPENIKRNLYLTK 360
PL + RD ++ + +S + M+ V + + + F + IK++ L
Sbjct: 364 TLCKGLPLAYNRDFQE---DKEPMFDSTKTIMGMIDVSAEFAQNVTFNEDRIKKS--LPA 418
Query: 361 NLIMAEPLMLKLAEKGMGRQEAHELVRQLAMKAFKEGRDLLEVVRKNEEAMKYLTENDLE 420
+ A L L +KGM + +H++V +L +G +L + + + + + E D+
Sbjct: 419 GHLDATTLADYLVKKGMPFRSSHDIVGKLVGVCVSKGCELQNLSLEEMKKLSPVFEEDVF 478
Query: 421 G-LKPENYIGK 430
G L EN + K
Sbjct: 479 GFLGVENSVNK 489
>pir||T50801 argininosuccinate lyase (AtArgH) - Arabidopsis thaliana
>gi|8979726|emb|CAB96847.1| (AL365234) argininosuccinate
lyase (AtArgH) [Arabidopsis thaliana]
Length = 517
Score = 72.6 bits (175), Expect = 8e-12
Identities = 87/371 (23%), Positives = 164/371 (43%), Gaps = 33/371 (8%)
Query: 73 EIHHDIMAVVKALSEVCGEHGKYVHLGATSNDIIDTANALLIKESLAIVEKDLKELRSIL 132
++H +I A AL+++ GE K +H + ND + T L ++++ + ++ L+ L
Sbjct: 139 DVHMNIEA---ALTDLIGEPAKKLHTARSRNDQVATDFRLWCRDAIDTIIVKIRNLQRAL 195
Query: 133 KELAKKHIDTVCIGRTHGQHAVPTTYGMKFALWLDEIQRHIERLQQLKDRVLVGKMRGAV 192
ELA K+ + G TH Q A P ++++++R R + R+ + GA
Sbjct: 196 VELALKNEALIVPGYTHLQRAQPVLLPHVLLTFVEQLERDAGRYVDCRARLNFSPL-GAC 254
Query: 193 GTAASFGDKAFEIEKLVMED-LGL-KPARIT-NQIIQRDVYAELMFFLALVASTLDKMAL 249
A + I++ + + LG +P R + + + RD E ++ T +
Sbjct: 255 ALAGT----GLPIDRFMTANALGFTEPMRNSIDAVSDRDFVLEFLY-------TNANTGI 303
Query: 250 EIRNLQRTEILEVSEPFG------EKQVGSSTMPHKRNPIRTEKVCGLARVLYSNVIPAL 303
+ L +L SE FG GSS MP K+NP E V G + + +++ L
Sbjct: 304 HLSRLGEEWVLWASEEFGFMTPSDSVSTGSSIMPQKKNPDPMELVRGKSARVIGDLVTVL 363
Query: 304 L---NNPLWHERDLTNSSVERVILPESFVLLDEMLKVMKKVLKGLEFFPENIKRNLYLTK 360
PL + RD ++ + +S + M+ V + + + F + IK++ L
Sbjct: 364 TLCKGLPLAYNRDFQE---DKEPMFDSTKTIMGMIDVSAEFAQNVTFNEDRIKKS--LPA 418
Query: 361 NLIMAEPLMLKLAEKGMGRQEAHELVRQLAMKAFKEGRDLLEVVRKNEEAMKYLTENDLE 420
+ A L L +KGM + +H++V +L +G +L + + + + + E D+
Sbjct: 419 GHLDATTLADYLVKKGMPFRSSHDIVGKLVGVCVSKGCELQNLSLEEMKKLSPVFEEDVF 478
Query: 421 G-LKPENYIGK 430
G L EN + K
Sbjct: 479 GFLGVENSVNK 489
>sp|Q9ZLI5|ASPA_HELPJ ASPARTATE AMMONIA-LYASE (ASPARTASE) >gi|7436846|pir||H71913
aspartate ammonia-lyase - Helicobacter pylori (strain
J99) >gi|4155137|gb|AAD06167.1| (AE001491) ASPARTATE
AMMONIA-LYASE [Helicobacter pylori J99]
Length = 468
Score = 72.2 bits (174), Expect = 1e-11
Identities = 93/376 (24%), Positives = 165/376 (43%), Gaps = 36/376 (9%)
Query: 67 VKEIEAEIHHDIMAVVKALSEVCGEHGKYVHLGATSNDIIDTANALLIKESLAIVEKDLK 126
+ E+ A + + M K + C + +V+ ++ND +A + I E L+ + +K
Sbjct: 105 MNEVIANLALEYMGHQKGEYQFCHPND-HVNRSQSTNDAYPSALKIAIYERLSNLVAPMK 163
Query: 127 ELRSILKELAKKHIDTVCIGRTHGQHAVPTTYGMKFALWLDEIQRHIERLQQLKDRVLVG 186
LR + AK+ + +GRT Q AVP T G +F + + R IE++ ++ V
Sbjct: 164 ALRDAFAQKAKEFAHVIKMGRTQLQDAVPMTLGQEFETYALMVDRDIEQVLDARNWVREL 223
Query: 187 KMRGAV-GTAA-SFGDKAFEIEKLVMEDLGLKPARITNQIIQ----RDVYAELMFFLALV 240
+ G V GT S D IEK + E G +P + N +I+ Y ++ L +
Sbjct: 224 NLGGTVIGTGINSHPDYRSLIEKKIQEVTG-RPFVMANNLIEATQSTGAYVQVSGVLKRI 282
Query: 241 ASTLDKMALEIRNLQ---RTEILEVSEPFGEKQVGSSTMPHKRNPIRTEKVCGLARVLYS 297
A L K+ ++R L R + E++ P + Q GSS MP K NP+ E V + +
Sbjct: 283 AVKLSKVCNDLRLLSSGPRAGLNEINLP--KMQPGSSIMPGKVNPVIPEVVNQVCFAVIG 340
Query: 298 NVIPALLNNPLWHERDLTNSSVERVI---LPESFVLLDEMLKVM-KKVLKGLEFFPENIK 353
N + L L + E VI L SFV+L ++ + K ++G+ +
Sbjct: 341 NDLSVAL---AAEGGQLQLNVFEPVIAYKLFHSFVILGRAIETLTTKCVEGITANEKICH 397
Query: 354 RNLYLTKNLIMAEPLMLKLAEKGMGRQEAHELVRQLAMKAFKEGRDLLEVVRKNEEAMKY 413
++ + ++ A + +E +A +A K R + ++ + K
Sbjct: 398 DYVFNSIGIVTA-----------LNPHIGYEKSAMIAKEALKSDRSIYDIALEK----KI 442
Query: 414 LTENDLEGL-KPENYI 428
LT+ L+ + KPEN +
Sbjct: 443 LTKEQLDDIFKPENML 458
>gb|AAF52721.1| (AE003623) CG9510 gene product [Drosophila melanogaster]
Length = 445
Score = 72.2 bits (174), Expect = 1e-11
Identities = 88/389 (22%), Positives = 170/389 (43%), Gaps = 57/389 (14%)
Query: 29 LDVEAALARAHAKLGNIPEESARVISERANTKWVKLERVKEIEAEIH-----HDIMAV-V 82
LD A A A + G I A + K ++L R IE + D+ V
Sbjct: 42 LDASKAYAEALHRAGLINSAEADKL-----VKNLELLRFDWIEGTVKILPGDEDVHTVNE 96
Query: 83 KALSEVCGEHGKYVHLGATSNDIIDTANALLIKESLAIVEKDLKELRSILKELAKKHIDT 142
+ L E+ GE G+ +H G + ND + T L +++++ L + A+ H+
Sbjct: 97 RLLVEITGELGQRLHTGRSRNDQVVTDMKLWLRKAIRETLGRLSGIIETATRQAELHLGV 156
Query: 143 VCIGRTHGQHAVPTTYGMKFALWLDEIQRHIERLQQLKDRVLVGKMRGAVGTAASFGDKA 202
+ G TH Q A ++F+ WL + A +
Sbjct: 157 LMPGYTHLQRA----QTVQFSHWL-------------------------LSHAGALAGNP 187
Query: 203 FEIEKL-VMEDLGLK--PARITNQIIQRDVYAELMFFLALVASTLDKMA--LEIRNLQRT 257
I++L + E LG A + + RD + ++ ++V+ L ++A L I + +
Sbjct: 188 LGIDRLWLAERLGFSGVTANSMHAVGDRDFVVDFIYCCSMVSLHLSRLAEDLIIYSTKEF 247
Query: 258 EILEVSEPFGEKQVGSSTMPHKRNPIRTEKVCGLARVLYSN---VIPALLNNPLWHERDL 314
+ +++++ F GSS MP KRNP E + G+A V+ +N ++ + P + +DL
Sbjct: 248 DFIKLADGFSS---GSSLMPQKRNPDSLELIRGMAGVITANLTGIMMTIKGTPSTYNKDL 304
Query: 315 TNSSVERVILPESFVLLDEMLKVMKKVLKGLEFFPENIKRNLYLTKNLIMAEPLMLKLAE 374
++ +SF L ++L+V VL+ ++ E+++ L ++A L +
Sbjct: 305 ---QYDKQFCFQSFDKLSQVLEVTDGVLQTIQVKQESMEAAL---STDMLATDWAYYLVK 358
Query: 375 KGMGRQEAHELVRQLAMKAFKEGRDLLEV 403
KG+ ++AH ++ ++ +A K G D+ ++
Sbjct: 359 KGVPFRQAHHIIGRVVSEAEKRGVDITDL 387
>sp|P07954|FUMH_HUMAN FUMARATE HYDRATASE, MITOCHONDRIAL PRECURSOR (FUMARASE)
>gi|1545996|gb|AAB66354.1| (U59309) fumarase precursor
[Homo sapiens] >gi|4097195|gb|AAD00071.1| (U48857)
fumarase [Homo sapiens]
Length = 510
Score = 71.4 bits (172), Expect = 2e-11
Identities = 88/347 (25%), Positives = 154/347 (44%), Gaps = 30/347 (8%)
Query: 95 YVHLGATSNDIIDTANALLIK-ESLAIVEKDLKELRSILKELAKKHIDTVCIGRTHGQHA 153
+V+ +SND TA + E ++ L++L L +K+ + IGRTH Q A
Sbjct: 180 HVNKSQSSNDTFPTAMHIAAAIEVHEVLLPGLQKLHDALDAKSKEFAQIIKIGRTHTQDA 239
Query: 154 VPTTYGMKFALWLDEIQRHIERLQQLKDRVLVGKMRG-AVGTAAS----FGDK-AFEIEK 207
VP T G +F+ ++ +++ + R++ R+ G AVGT + F +K A ++
Sbjct: 240 VPLTLGQEFSGYVQQVKYAMTRIKAAMPRIYELAAGGTAVGTGLNTRIGFAEKVAAKVAA 299
Query: 208 LVMEDLGLKPARITNQIIQRDVYAELMFFLALVASTLDKMALEIRNL---QRTEILEVSE 264
L P + + D EL + A +L K+A +IR L R+ + E+
Sbjct: 300 LTGLPFVTAPNKF-EALAAHDALVELSGAMNTTACSLMKIANDIRFLGSGPRSGLGELIL 358
Query: 265 PFGEKQVGSSTMPHKRNPIRTEKVCGLARVLYSNVIPALLNNPLWH-ERDLTNSSVERVI 323
P E + GSS MP K NP + E + +A + N + + H E ++ + + +
Sbjct: 359 P--ENEPGSSIMPGKVNPTQCEAMTMVAAQVMGNHVAVTVGGSNGHFELNVFKPMMIKNV 416
Query: 324 LPESFVLLDEMLKVMKKVLKGLEFFPENIKRNLYLTKNLIMAEPLMLKLAEKGMGRQEAH 383
L + +L D + + + G++ E I N +M E LML A + +
Sbjct: 417 LHSARLLGDASVSFTENCVVGIQANTERI--------NKLMNESLMLVTA---LNPHIGY 465
Query: 384 ELVRQLAMKAFKEGRDLLEVVRKNEEAMKYLTENDL-EGLKPENYIG 429
+ ++A A K G L E + + YLT E +KP++ +G
Sbjct: 466 DKAAKIAKTAHKNGSTLKETAIE----LGYLTAEQFDEWVKPKDMLG 508
>dbj|BAB08741.1| (AB017063) fumarate hydratase [Arabidopsis thaliana]
Length = 499
Score = 71.4 bits (172), Expect = 2e-11
Identities = 90/347 (25%), Positives = 149/347 (42%), Gaps = 30/347 (8%)
Query: 95 YVHLGATSNDIIDTA-NALLIKESLAIVEKDLKELRSILKELAKKHIDTVCIGRTHGQHA 153
+V+ +SND T + E + + LK L S L+ + + D V IGRTH Q A
Sbjct: 168 HVNRSQSSNDTFPTVMHIAAATEITSRLIPSLKNLHSSLESKSFEFKDIVKIGRTHTQDA 227
Query: 154 VPTTYGMKFALWLDEIQRHIERLQQLKDRVLVGKMRG-AVGTAASFGDKAFEIE--KLVM 210
P T G +F + +++ + R+ R+ G AVGT + K F+++ V
Sbjct: 228 TPLTLGQEFGGYATQVEYGLNRVACTLPRIYQLAQGGTAVGTGLN-TKKGFDVKIAAAVA 286
Query: 211 EDLGLKPARITNQ---IIQRDVYAELMFFLALVASTLDKMALEIRNL---QRTEILEVSE 264
E+ L N+ + D E L +A++L K+A +IR L R + E+S
Sbjct: 287 EETNLPFVTAENKFEALAAHDACVETSGSLNTIATSLMKIANDIRFLGSGPRCGLGELSL 346
Query: 265 PFGEKQVGSSTMPHKRNPIRTEKVCGLARVLYSNVIPALLNNPLWH-ERDLTNSSVERVI 323
P E + GSS MP K NP + E + + + N + + H E ++ + +
Sbjct: 347 P--ENEPGSSIMPGKVNPTQCEALTMVCAQVMGNHVAVTIGGSNGHFELNVFKPVIASAL 404
Query: 324 LPESFVLLDEMLKVMKKVLKGLEFFPENIKRNLYLTKNLIMAEPLMLKLAEKGMGRQEAH 383
L ++ D K ++G+E E I + L+ E LML + + + +
Sbjct: 405 LHSIRLIADASASFEKNCVRGIEANRERISKLLH--------ESLMLVTS---LNPKIGY 453
Query: 384 ELVRQLAMKAFKEGRDLLEVVRKNEEAMKYLTENDLEGL-KPENYIG 429
+ +A +A KEG L K + LT + + L PE IG
Sbjct: 454 DNAAAVAKRAHKEGCTLKHAAMK----LGVLTSEEFDTLVVPEKMIG 496
>sp|P05042|FUMC_ECOLI FUMARATE HYDRATASE CLASS II (FUMARASE) >gi|68298|pir||UFEC fumarate
hydratase (EC 4.2.1.2) fumC [validated] - Escherichia
coli >gi|1942160|pdb|1FUO|A Chain A, Fumarase C With
Bound Citrate >gi|1942161|pdb|1FUO|B Chain B, Fumarase C
With Bound Citrate >gi|41513|emb|CAA27698.1| (X04065)
fumarase (fumC, AA 1-467) [Escherichia coli]
>gi|1742650|dbj|BAA15349.1| (D90803) Fumarate hydratase
(EC 4.2.1.2) FumC [Escherichia coli]
>gi|1742661|dbj|BAA15359.1| (D90804) Fumarate hydratase
(EC 4.2.1.2) FumC [Escherichia coli]
>gi|1787896|gb|AAC74683.1| (AE000256) fumarase C=
fumarate hydratase Class II; isozyme [Escherichia coli
K12]
Length = 467
Score = 70.2 bits (169), Expect = 4e-11
Identities = 93/351 (26%), Positives = 151/351 (42%), Gaps = 34/351 (9%)
Query: 96 VHLGATSNDIIDTAN---ALLIKESLAIVEKDLKELRSILKELAKKHIDTVCIGRTHGQH 152
V+ +SND+ TA ALL I + LK L L E ++ D V IGRTH Q
Sbjct: 134 VNKSQSSNDVFPTAMHVAALLALRKQLIPQ--LKTLTQTLNEKSRAFADIVKIGRTHLQD 191
Query: 153 AVPTTYGMKFALWLDEIQRHIERLQQLKDRVLVGKMRG-AVGTAASFGDK-----AFEIE 206
A P T G + + W+ ++ +++ ++ V + G AVGT + + A E+
Sbjct: 192 ATPLTLGQEISGWVAMLEHNLKHIEYSLPHVAELALGGTAVGTGLNTHPEYARRVADELA 251
Query: 207 KLVMEDLGLKPARITNQIIQRDVYAELMFFLALVASTLDKMALEIRNL---QRTEILEVS 263
+ P + + D + L +A++L K+A ++R L R I E+S
Sbjct: 252 VITCAPFVTAPNKF-EALATCDALVQAHGALKGLAASLMKIANDVRWLASGPRCGIGEIS 310
Query: 264 EPFGEKQVGSSTMPHKRNPIRTEKVCGLARVLYSNVIPALLNNPLWH-ERDLTNSSVERV 322
P E + GSS MP K NP + E + L + N + + + E ++ V
Sbjct: 311 IP--ENEPGSSIMPGKVNPTQCEALTMLCCQVMGNDVAINMGGASGNFELNVFRPMVIHN 368
Query: 323 ILPESFVLLDEMLKVMKKVLKGLEFFPENIKRNLYLTKNLIMAEPLMLKLAEKGMGRQEA 382
L +L D M K G+E E I N ++ E LML A +
Sbjct: 369 FLQSVRLLADGMESFNKHCAVGIEPNRERI--------NQLLNESLMLVTA---LNTHIG 417
Query: 383 HELVRQLAMKAFKEGRDLLEVVRKNEEAMKYLTENDLEG-LKPENYIGKAR 432
++ ++A KA KEG L + A+ YL+E + + ++PE +G +
Sbjct: 418 YDKAAEIAKKAHKEGLTL----KAAALALGYLSEAEFDSWVRPEQMVGSMK 464
>sp|P43061|ARLY_CANAL ARGININOSUCCINATE LYASE (ARGINOSUCCINASE) (ASAL)
>gi|7596999|gb|AAA34323.2| (L25051) argininosuccinate
lyase [Candida albicans]
Length = 468
Score = 70.2 bits (169), Expect = 4e-11
Identities = 86/373 (23%), Positives = 162/373 (43%), Gaps = 38/373 (10%)
Query: 41 KLGNIPEESARVIS---ERANTKWVKLERV-KEIEAEIHHDIMAVVKALSEVCGEH--GK 94
KLG I E +I E+ +W + + K + +IH A + L E+ G++ GK
Sbjct: 57 KLGLITTEELNLIHQGLEQIRQEWHDNKFIIKAGDEDIH---TANERRLGEIIGKNISGK 113
Query: 95 YVHLGATSNDIIDTANALLIKESLAIVEKDLKELRSILKELAKKHIDTVCIGRTHGQHAV 154
VH G + ND + T + ++ESL + K L + + + E A K ID + G TH Q A
Sbjct: 114 -VHTGRSRNDQVATDMRIFVRESLLNLSKILHQFITAILERAHKEIDVLMPGYTHLQKAQ 172
Query: 155 PTTYGMKFALWLDEIQRHIERLQQLKDRVLVGKMRGAVGTAASFGDKAFEIEKLVMEDLG 214
P + + + +RLQ++ RV + +G+ A G + + + LG
Sbjct: 173 PIRWAHWLSSYATYFTEDYKRLQEIITRV----NQSPLGSGALAGHPYGIDREFLAKGLG 228
Query: 215 LKP--ARITNQIIQRDVYAELMFFLALVASTLDKMALEIRNLQRTEILEVSEPFG----- 267
+ RD E +F+ L + + + + ++ I+ S FG
Sbjct: 229 FDGVIGNSLTAVSDRDFVVESLFWSTLFMNHISRFSEDL-------IIYSSGEFGFIKLA 281
Query: 268 -EKQVGSSTMPHKRNPIRTEKVCGLARVLY---SNVIPALLNNPLWHERDLTNSSVERVI 323
GSS MP K+NP E + G + ++ S + ++ + P + +D+ ++
Sbjct: 282 DAYSTGSSLMPQKKNPDSLELLRGKSGRVFGQLSGFLMSIKSIPSTYNKDMQE---DKEP 338
Query: 324 LPESFVLLDEMLKVMKKVLKGLEFFPENIKRNLYLTKNLIMAEPLMLKLAEKGMGRQEAH 383
L ++ ++ + + V+ L +N+++ L + ++A L L KG+ +E H
Sbjct: 339 LFDALTTVEHSILIATGVISTLSIDKQNMEKALTMD---MLATDLADYLVRKGVPFRETH 395
Query: 384 ELVRQLAMKAFKE 396
+ + KA +E
Sbjct: 396 HISGECVRKAEEE 408
>pdb|1FUQ|A Chain A, Fumarase With Bound Pyromellitic Acid
>gi|1942162|pdb|1FUP|A Chain A, Fumarase With Bound
Pyromellitic Acid >gi|1942163|pdb|1FUP|B Chain B,
Fumarase With Bound Pyromellitic Acid
>gi|1942165|pdb|1FUQ|B Chain B, Fumarase With Bound
Pyromellitic Acid
Length = 472
Score = 70.2 bits (169), Expect = 4e-11
Identities = 93/351 (26%), Positives = 151/351 (42%), Gaps = 34/351 (9%)
Query: 96 VHLGATSNDIIDTAN---ALLIKESLAIVEKDLKELRSILKELAKKHIDTVCIGRTHGQH 152
V+ +SND+ TA ALL I + LK L L E ++ D V IGRTH Q
Sbjct: 134 VNKSQSSNDVFPTAMHVAALLALRKQLIPQ--LKTLTQTLNEKSRAFADIVKIGRTHLQD 191
Query: 153 AVPTTYGMKFALWLDEIQRHIERLQQLKDRVLVGKMRG-AVGTAASFGDK-----AFEIE 206
A P T G + + W+ ++ +++ ++ V + G AVGT + + A E+
Sbjct: 192 ATPLTLGQEISGWVAMLEHNLKHIEYSLPHVAELALGGTAVGTGLNTHPEYARRVADELA 251
Query: 207 KLVMEDLGLKPARITNQIIQRDVYAELMFFLALVASTLDKMALEIRNL---QRTEILEVS 263
+ P + + D + L +A++L K+A ++R L R I E+S
Sbjct: 252 VITCAPFVTAPNKF-EALATCDALVQAHGALKGLAASLMKIANDVRWLASGPRCGIGEIS 310
Query: 264 EPFGEKQVGSSTMPHKRNPIRTEKVCGLARVLYSNVIPALLNNPLWH-ERDLTNSSVERV 322
P E + GSS MP K NP + E + L + N + + + E ++ V
Sbjct: 311 IP--ENEPGSSIMPGKVNPTQCEALTMLCCQVMGNDVAINMGGASGNFELNVFRPMVIHN 368
Query: 323 ILPESFVLLDEMLKVMKKVLKGLEFFPENIKRNLYLTKNLIMAEPLMLKLAEKGMGRQEA 382
L +L D M K G+E E I N ++ E LML A +
Sbjct: 369 FLQSVRLLADGMESFNKHCAVGIEPNRERI--------NQLLNESLMLVTA---LNTHIG 417
Query: 383 HELVRQLAMKAFKEGRDLLEVVRKNEEAMKYLTENDLEG-LKPENYIGKAR 432
++ ++A KA KEG L + A+ YL+E + + ++PE +G +
Sbjct: 418 YDKAAEIAKKAHKEGLTL----KAAALALGYLSEAEFDSWVRPEQMVGSMK 464
>pdb|2FUS|A Chain A, Mutations Of Fumarase That Distinguish Between The Active
Site And A Nearby Dicarboxylic Acid Binding Site
>gi|2392683|pdb|2FUS|B Chain B, Mutations Of Fumarase
That Distinguish Between The Active Site And A Nearby
Dicarboxylic Acid Binding Site
Length = 467
Score = 70.2 bits (169), Expect = 4e-11
Identities = 93/351 (26%), Positives = 151/351 (42%), Gaps = 34/351 (9%)
Query: 96 VHLGATSNDIIDTAN---ALLIKESLAIVEKDLKELRSILKELAKKHIDTVCIGRTHGQH 152
V+ +SND+ TA ALL I + LK L L E ++ D V IGRTH Q
Sbjct: 134 VNKSQSSNDVFPTAMHVAALLALRKQLIPQ--LKTLTQTLNEKSRAFADIVKIGRTHLQD 191
Query: 153 AVPTTYGMKFALWLDEIQRHIERLQQLKDRVLVGKMRG-AVGTAASFGDK-----AFEIE 206
A P T G + + W+ ++ +++ ++ V + G AVGT + + A E+
Sbjct: 192 ATPLTLGQEISGWVAMLEHNLKHIEYSLPHVAELALGGTAVGTGLNTHPEYARRVADELA 251
Query: 207 KLVMEDLGLKPARITNQIIQRDVYAELMFFLALVASTLDKMALEIRNL---QRTEILEVS 263
+ P + + D + L +A++L K+A ++R L R I E+S
Sbjct: 252 VITCAPFVTAPNKF-EALATCDALVQAHGALKGLAASLMKIANDVRWLASGPRCGIGEIS 310
Query: 264 EPFGEKQVGSSTMPHKRNPIRTEKVCGLARVLYSNVIPALLNNPLWH-ERDLTNSSVERV 322
P E + GSS MP K NP + E + L + N + + + E ++ V
Sbjct: 311 IP--ENEPGSSIMPGKVNPTQCEALTMLCCQVMGNDVAINMGGASGNFELNVFRPMVIHN 368
Query: 323 ILPESFVLLDEMLKVMKKVLKGLEFFPENIKRNLYLTKNLIMAEPLMLKLAEKGMGRQEA 382
L +L D M K G+E E I N ++ E LML A +
Sbjct: 369 FLQSVRLLADGMESFNKHCAVGIEPNRERI--------NQLLNESLMLVTA---LNTHIG 417
Query: 383 HELVRQLAMKAFKEGRDLLEVVRKNEEAMKYLTENDLEG-LKPENYIGKAR 432
++ ++A KA KEG L + A+ YL+E + + ++PE +G +
Sbjct: 418 YDKAAEIAKKAHKEGLTL----KAAALALGYLSEAEFDSWVRPEQMVGSMK 464
>emb|CAB95018.1| (AJ252020) argininosuccinase and n-acetylglutamate synthase
[Moritella sp. 2674]
Length = 470
Score = 69.9 bits (168), Expect = 6e-11
Identities = 92/396 (23%), Positives = 169/396 (42%), Gaps = 23/396 (5%)
Query: 34 ALARAHAKLGNIPEESARVISERANT-KWVKLERVKEIEAEIHHDIMAVVKA-LSEVCGE 91
A ++A +G + ++ I N K LE ++I DI + V+ L G+
Sbjct: 39 AWSKALVSVGILTQDEQLTIEAALNDLKLAVLENPEQILQSDAEDIHSWVETQLIAKVGD 98
Query: 92 HGKYVHLGATSNDIIDTANALLIKESLAIVEKDLKELRSILKELAKKHIDTVCIGRTHGQ 151
GK +H G + ND + T L K+ + L + + L LA++H TV G TH Q
Sbjct: 99 LGKKLHTGRSRNDQVATDLKLWCKQQGEQLLMQLDKTQQQLVSLAREHQHTVLPGYTHLQ 158
Query: 152 HAVPTTYGMKFALWLDEIQRHIERLQQLKDRVLVGKMRGAVGTAASFGDKAFEIEKL-VM 210
A P T+ +++ ++R RL R+ + G+ A G A+ +++ +
Sbjct: 159 RAQPVTFSHWCLAYVEMLERDFSRLTDCLKRLDTCPL----GSGALAG-TAYPMDRTELA 213
Query: 211 EDLGLKPARIT--NQIIQRDVYAELMFFLALVASTLDKMA--LEIRNLQRTEILEVSEPF 266
LG A + + + RD ELM ++ L ++A L N + +E+++
Sbjct: 214 HTLGFASATLNSLDSVSDRDHVMELMSTASMSMIHLSRLAEDLIFYNSGESNFIELADAV 273
Query: 267 GEKQVGSSTMPHKRNPIRTEKVCGLARVLYSNVIPALLN---NPLWHERDLTNSSVERVI 323
GSS MP K+NP E + G ++ ++ L+ PL + +D+ ++
Sbjct: 274 TS---GSSLMPQKKNPDALELIRGKTGRVFGSLSAMLMTLKALPLAYNKDMQE---DKEG 327
Query: 324 LPESFVLLDEMLKVMKKVLKGLEFFPENIKRNLYLTKNLIMAEPLMLKLAEKGMGRQEAH 383
L ++ + L++ L G++ E K A L L KG+ +++H
Sbjct: 328 LFDALDTWSDCLEMAAMSLVGMKINEERTKE--AALGGYSNATELADYLVAKGVPFRDSH 385
Query: 384 ELVRQLAMKAFKEGRDLLEVVRKNEEAMKYLTENDL 419
+V + + A +G L + +A L E+D+
Sbjct: 386 HIVGEAVVAAIAKGVPLEALTLAEFKAFDVLIEDDV 421
>pir||T00433 fumarate hydratase (EC 4.2.1.2) - Arabidopsis thaliana
>gi|2443751|gb|AAB71399.1| (AF020303) fumarase
[Arabidopsis thaliana] >gi|2529676|gb|AAC62859.1|
(AC002535) putative fumarase [Arabidopsis thaliana]
Length = 492
Score = 69.5 bits (167), Expect = 7e-11
Identities = 91/355 (25%), Positives = 150/355 (41%), Gaps = 30/355 (8%)
Query: 87 EVCGEHGKYVHLGATSNDIIDTANALLIKESL-AIVEKDLKELRSILKELAKKHIDTVCI 145
E C +V+ +SND T + + + + LK L S L+ + + D V I
Sbjct: 153 EKCVHPNDHVNRSQSSNDTFPTVMHIAAATEINSRLIPSLKTLHSTLESKSFEFKDIVKI 212
Query: 146 GRTHGQHAVPTTYGMKFALWLDEIQRHIERLQQLKDRVLVGKMRG-AVGTAASFGDKAFE 204
GRTH Q A P T G +F + +++ + R+ R+ G AVGT + K F+
Sbjct: 213 GRTHTQDATPLTLGQEFGGYATQVKYGLNRVTCTLPRLYQLAQGGTAVGTGLN-TKKGFD 271
Query: 205 IE--KLVMEDLGLKPARITNQ---IIQRDVYAELMFFLALVASTLDKMALEIRNL---QR 256
++ V E+ L N+ + D E L +A++L K+A +IR L R
Sbjct: 272 VKIAAAVAEETNLPFVTAENKFEALAAHDACVETSGSLNTIATSLMKIANDIRFLGSGPR 331
Query: 257 TEILEVSEPFGEKQVGSSTMPHKRNPIRTEKVCGLARVLYSNVIPALLNNPLWH-ERDLT 315
+ E+ P E + GSS MP K NP + E + + + N + + H E ++
Sbjct: 332 CGLGELVLP--ENEPGSSIMPGKVNPTQCEALTMVCAQVMGNHVAVTVGGSNGHFELNVF 389
Query: 316 NSSVERVILPESFVLLDEMLKVMKKVLKGLEFFPENIKRNLYLTKNLIMAEPLMLKLAEK 375
+ +L ++ D K ++G+E E I + L+ E LML +
Sbjct: 390 KPVIASALLHSVRLIADASASFEKNCVRGIEANRERISKLLH--------ESLMLVTS-- 439
Query: 376 GMGRQEAHELVRQLAMKAFKEGRDLLEVVRKNEEAMKYLTENDLEGL-KPENYIG 429
+ + ++ +A KA KEG L E + LT + + L PE IG
Sbjct: 440 -LNPKIGYDNAAAVAKKAHKEGCTLKEAALN----LGVLTAEEFDTLVVPEKMIG 489
>sp|O74026|ARLY_METMP ARGININOSUCCINATE LYASE (ARGINOSUCCINASE) (ASAL)
>gi|3287177|emb|CAA76302.1| (Y16584) argininosuccinate
lyase [Methanococcus maripaludis]
Length = 481
Score = 69.5 bits (167), Expect = 7e-11
Identities = 99/389 (25%), Positives = 171/389 (43%), Gaps = 35/389 (8%)
Query: 77 DIMAVVKALSEVCGEHGKYV----HLGATSNDIIDTANALLIKESLAIVEKDLKELRSIL 132
DI V++ SE+ E G+ V H G + ND + T L +++ + + L + +
Sbjct: 82 DIHMVIE--SELIKELGEDVAGRMHTGRSRNDEVATDLRLSLRKKVLEIIGHLITMEKNM 139
Query: 133 KELAKKHIDTVCIGRTHGQHAVPTTYGMKFALWLDEIQRHIERLQQLKDRVLVGKMRGAV 192
++ H +T+ +G TH Q A P T+G + + I+R I R +R+ + +
Sbjct: 140 LTVSDAHKETLTVGYTHLQQAQPVTFGHQILSHVSAIERDISRFFDTYNRINISPL--GC 197
Query: 193 GTAASFGDKAFEIEKLVMEDLGLKPARITNQ---IIQRDVYAELMFFLALVASTLDKMAL 249
G A+ G F + + +DL I N + RD E M ++++ + L K+
Sbjct: 198 GAMATTG---FNLNRKRTKDLLGFYGIIENSMDGVSSRDFIVETMANISMLGTNLSKICE 254
Query: 250 EIRNLQRTEILEVSEPFGEKQVGSSTMPHKRNP----IRTEKVCGLARVLYSNVIPALLN 305
E+ E + E E SS MP K+NP I K+ L L + V+ +
Sbjct: 255 ELVVFSSAEFNTI-EIANEYTSTSSIMPQKKNPDVAEITRAKLSTLNGELVT-VLTIMKA 312
Query: 306 NPLWHERDLTNSSVERVILPESFVLLDEMLKVMKKVLKGLEFFPENIKRNLYLTKNLIMA 365
P + RDL S L +S L + ++++ ++ ++ E +K N KN A
Sbjct: 313 LPNTYNRDLQEISPH---LWKSVYTLIDSIQMVDGMISTVKVNKERMKEN--AEKNYSTA 367
Query: 366 EPLMLKLA-EKGMGRQEAHELVRQLAMKAFKEGRDLLEVV----RKNEEAM---KYLTEN 417
L L E G+ + AH +V +L ++ +E ++ E++ KN ++ K T
Sbjct: 368 TELADTLVRECGIAFRMAHGIVGELVKRSIEEKVEIKEIISEVLEKNNLSLSQEKIDTAL 427
Query: 418 D-LEGLKPENYI-GKAREIVENVVNYVEE 444
D E +K N I G A E VE ++ E
Sbjct: 428 DPFENVKLRNVIGGPAPEEVERAISSFNE 456
>sp|P55250|FUMH_RHIOR FUMARATE HYDRATASE PRECURSOR (FUMARASE) >gi|469103|emb|CAA55314.1|
(X78576) fumarase [Rhizopus oryzae]
Length = 494
Score = 69.5 bits (167), Expect = 7e-11
Identities = 93/348 (26%), Positives = 156/348 (44%), Gaps = 34/348 (9%)
Query: 95 YVHLGATSNDIIDTA-NALLIKESLAIVEKDLKELRSILKELAKKHIDTVCIGRTHGQHA 153
+V++ +SND TA + + E + L LR L+ + + + IGRTH Q A
Sbjct: 163 HVNMSQSSNDTFPTAMHVAAVVEIHGRLIPALTTLRDALQAKSAEFEHIIKIGRTHLQDA 222
Query: 154 VPTTYGMKFALWLDEIQRHIERLQQLKDRVLVGKMRG-AVGTAASFGDKAFE--IEKLVM 210
P T G +F+ + ++ I R+Q +R+ G AVGT + K F+ + + +
Sbjct: 223 TPLTLGQEFSGYTQQLTYGIARVQGTLERLYNLAQGGTAVGTGLN-TRKGFDAKVAEAIA 281
Query: 211 EDLGLKPARITNQ---IIQRDVYAELMFFLALVASTLDKMALEIRNL---QRTEILEVSE 264
GL N+ + D E L VA +L K+A +IR L R + E+S
Sbjct: 282 SITGLPFKTAPNKFEALAAHDALVEAHGALNTVACSLMKIANDIRYLGSGPRCGLGELSL 341
Query: 265 PFGEKQVGSSTMPHKRNPIRTE---KVCGLARVLYSNVIPALLNNPLWHERDLTNSSVER 321
P E + GSS MP K NP + E VC A+V+ +N ++ + E ++ + +
Sbjct: 342 P--ENEPGSSIMPGKVNPTQCEAMTMVC--AQVMGNNTAISVAGSNGQFELNVFKPVMIK 397
Query: 322 VILPESFVLLDEMLKVMKKVLKGLEFFPENIKRNLYLTKNLIMAEPLMLKLAEKGMGRQE 381
++ ++ D + K + G+E + I + IM E LML A +
Sbjct: 398 NLIQSIRLISDASISFTKNCVVGIEANEKKI--------SSIMNESLMLVTA---LNPHI 446
Query: 382 AHELVRQLAMKAFKEGRDLLEVVRKNEEAMKYLTENDL-EGLKPENYI 428
++ + A KA KEG L E ++ YLT + + ++PE+ I
Sbjct: 447 GYDKAAKCAKKAHKEGTTLKEAAL----SLGYLTSEEFDQWVRPEDMI 490
>pir||JC4293 fumarate hydratase (EC 4.2.1.2) precursor - Rhizopus oryzae
Length = 494
Score = 69.5 bits (167), Expect = 7e-11
Identities = 93/348 (26%), Positives = 156/348 (44%), Gaps = 34/348 (9%)
Query: 95 YVHLGATSNDIIDTA-NALLIKESLAIVEKDLKELRSILKELAKKHIDTVCIGRTHGQHA 153
+V++ +SND TA + + E + L LR L+ + + + IGRTH Q A
Sbjct: 163 HVNMSQSSNDTFPTAMHVAAVVEIHGRLIPALTTLRDALQAKSAEFEHIIKIGRTHLQDA 222
Query: 154 VPTTYGMKFALWLDEIQRHIERLQQLKDRVLVGKMRG-AVGTAASFGDKAFE--IEKLVM 210
P T G +F+ + ++ I R+Q +R+ G AVGT + K F+ + + +
Sbjct: 223 TPLTLGQEFSGYTQQLTYGIARVQGTLERLYNLAQGGTAVGTGLN-TRKGFDAKVAEAIA 281
Query: 211 EDLGLKPARITNQ---IIQRDVYAELMFFLALVASTLDKMALEIRNL---QRTEILEVSE 264
GL N+ + D E L VA +L K+A +IR L R + E+S
Sbjct: 282 SITGLPFKTAPNKFEALAAHDALVEAHGALNTVACSLMKIANDIRYLGSGPRCGLGELSL 341
Query: 265 PFGEKQVGSSTMPHKRNPIRTE---KVCGLARVLYSNVIPALLNNPLWHERDLTNSSVER 321
P E + GSS MP K NP + E VC A+V+ +N ++ + E ++ + +
Sbjct: 342 P--ENEPGSSIMPGKVNPTQCEAMTMVC--AQVMGNNTAISVAGSNGQFELNVFKPVMIK 397
Query: 322 VILPESFVLLDEMLKVMKKVLKGLEFFPENIKRNLYLTKNLIMAEPLMLKLAEKGMGRQE 381
++ ++ D + K + G+E + I + IM E LML A +
Sbjct: 398 NLIQSIRLISDASISFTKNCVVGIEANEKKI--------SSIMNESLMLVTA---LNPHI 446
Query: 382 AHELVRQLAMKAFKEGRDLLEVVRKNEEAMKYLTENDL-EGLKPENYI 428
++ + A KA KEG L E ++ YLT + + ++PE+ I
Sbjct: 447 GYDKAAKCAKKAHKEGTTLKEAAL----SLGYLTSEEFDQWVRPEDMI 490
>gb|AAB97818.1| (AF013216) fumarate hydratase [Myxococcus xanthus]
Length = 466
Score = 69.5 bits (167), Expect = 7e-11
Identities = 78/285 (27%), Positives = 130/285 (45%), Gaps = 24/285 (8%)
Query: 96 VHLGATSNDIIDTANALLIKESLAI-VEKDLKELRSILKELAKKHIDTVCIGRTHGQHAV 154
V+ G +SND+ TA ++ ++ V +LK LR +L + A+ D V +GRTH Q A
Sbjct: 136 VNKGQSSNDVFPTAMSVAAVAAITEHVLPELKALRDVLAQKARAFHDVVKVGRTHLQDAT 195
Query: 155 PTTYGMK---FALWLDEIQRHIER-LQQLKDRVLVGKMRGAVGTAAS----FGDK-AFEI 205
P T G + F LD + H+ER L L + L G AVGT + + ++ A E+
Sbjct: 196 PLTLGQEVGGFVAQLDHAKGHLERTLPHLLELALGGT---AVGTGLNAPKGYAERVAQEL 252
Query: 206 EKLVMEDLGLKPARITNQIIQRDVYAELMFFLALVASTLDKMALEIRNLQ---RTEILEV 262
+L P + + D + L +A+ L K+A ++R L R+ + E+
Sbjct: 253 AQLTGHPFVTAPNKF-EALAANDALVQAHGALKGLAAVLFKVANDVRWLSSGPRSGLAEI 311
Query: 263 SEPFGEKQVGSSTMPHKRNPIRTEKVCGLARVLYSNVIPALLNNPLWH-ERDLTNSSVER 321
+ P E + GSS MP K NP ++E + L + N + + + + ++ +
Sbjct: 312 TIP--ENEPGSSIMPGKVNPTQSEALTMLCAQVMGNDVAVTVGGASGNFQLNVFKPLIAH 369
Query: 322 VILPESFVLLDEMLKVMKKVLKGLE----FFPENIKRNLYLTKNL 362
+L +L D M G+E EN++R+L L L
Sbjct: 370 NLLQSCRLLADGMRSFRLHCAVGIEPNRPRIQENLERSLMLVTAL 414
>gb|AAF00228.1|AF173956_1 (AF173956) argininosuccinate lyase [Cloning vector pRS-Arg4*SpeI]
Length = 468
Score = 69.1 bits (166), Expect = 1e-10
Identities = 86/373 (23%), Positives = 162/373 (43%), Gaps = 38/373 (10%)
Query: 41 KLGNIPEESARVIS---ERANTKWVKLERV-KEIEAEIHHDIMAVVKALSEVCGEH--GK 94
KLG I E +I E+ +W + + K + +IH A + L E+ G++ GK
Sbjct: 57 KLGLITTEELNLIHQGLEQIRQEWHDNKFIIKAGDEDIH---TANERRLGEIIGKNISGK 113
Query: 95 YVHLGATSNDIIDTANALLIKESLAIVEKDLKELRSILKELAKKHIDTVCIGRTHGQHAV 154
VH G + ND + T + ++ESL + K L + + + E A K ID + G TH Q A
Sbjct: 114 -VHTGRSRNDQVATDMRIFVRESLLNLSKILHQFITAILERAHKEIDVLMPGYTHLQKAQ 172
Query: 155 PTTYGMKFALWLDEIQRHIERLQQLKDRVLVGKMRGAVGTAASFGDKAFEIEKLVMEDLG 214
P + + + +RLQ++ RV + +G+ A G + + + LG
Sbjct: 173 PIRWAHWLSSYATYFTEDYKRLQEIITRV----NQSPLGSGALAGHPYGIDREFLAKGLG 228
Query: 215 LKP--ARITNQIIQRDVYAELMFFLALVASTLDKMALEIRNLQRTEILEVSEPFG----- 267
+ RD E +F+ L + + + + ++ I+ S FG
Sbjct: 229 FDGVIGNSLTAVSDRDFVVESLFWSTLFMNHISRFSEDL-------IIYSSGEFGFIKLA 281
Query: 268 -EKQVGSSTMPHKRNPIRTEKVCGLARVLY---SNVIPALLNNPLWHERDLTNSSVERVI 323
GSS MP K+NP E + G + ++ S + ++ + P + +D+ ++
Sbjct: 282 DAYSTGSSLMPQKKNPDSLELLRGKSGRVFGQLSGFLMSIKSIPSTYNKDMQE---DKEP 338
Query: 324 LPESFVLLDEMLKVMKKVLKGLEFFPENIKRNLYLTKNLIMAEPLMLKLAEKGMGRQEAH 383
L ++ ++ + + V+ L +N+++ L + ++A L L KG+ +E H
Sbjct: 339 LFDALTTVEHSILIATGVISTLLIDKQNMEKALTMD---MLATDLADYLVRKGVPFRETH 395
Query: 384 ELVRQLAMKAFKE 396
+ + KA +E
Sbjct: 396 HISGECVRKAEEE 408
>dbj|BAA93044.1| (AB028242) aspartase [Bacillus sp. YM55-1]
Length = 468
Score = 69.1 bits (166), Expect = 1e-10
Identities = 98/415 (23%), Positives = 169/415 (40%), Gaps = 64/415 (15%)
Query: 31 VEAALARAHAKLGNIPEESARVISERANT----KWVKLERVKEIEA----EIHHDIMAVV 82
V+ + A A+ ++G + +E + I + A+ KW V I+ I+ + V+
Sbjct: 52 VKKSAALANMEVGLLDKEVGQYIVKAADEVIEGKWNDQFIVDPIQGGAGTSINMNANEVI 111
Query: 83 --KALSEVCGEHGKY--------VHLGATSNDIIDTANALLIKESLAIVEKDLKELRSIL 132
+AL + E G Y V++ ++ND TA + + L + + K ++
Sbjct: 112 ANRALELMGEEKGNYSKISPNSHVNMSQSTNDAFPTATHIAVLSLLNQLIETTKYMQQEF 171
Query: 133 KELAKKHIDTVCIGRTHGQHAVPTTYGMKFALWLDEIQRHIERLQQLKDRVL-VGKMRGA 191
+ A + + +GRTH Q AVP G +F + I R IER+ ++ + + A
Sbjct: 172 MKKADEFAGVIKMGRTHLQDAVPILLGQEFEAYARVIARDIERIANTRNNLYDINMGATA 231
Query: 192 VGTAASFGDKAFEIEKLVMEDLGLKPARITNQII----QRDVYAELMFFLALVASTLDKM 247
VGT + + I + P R ++ D Y E+ L + + K+
Sbjct: 232 VGTGLNADPEYISIVTEHLAKFSGHPLRSAQHLVDATQNTDCYTEVSSALKVCMINMSKI 291
Query: 248 ALEIRNL---QRTEILEVSEPFGEKQVGSSTMPHKRNPIRTEKVCGLARVLYSNVIPALL 304
A ++R + R + E+ P +Q GSS MP K NP+ E + +A ++ N
Sbjct: 292 ANDLRLMASGPRAGLSEIVLP--ARQPGSSIMPGKVNPVMPEVMNQVAFQVFGN------ 343
Query: 305 NNPLWHERDLTNSSVE-------RVILPESFVLLDEMLKVMKKVLKGLEFFPENIKRNLY 357
DLT +S V+ P F L + + +M V K F EN
Sbjct: 344 --------DLTITSASEAGQFELNVMEPVLFFNLIQSISIMTNVFKS---FTEN------ 386
Query: 358 LTKNLIMAEPLMLKLAEKGMGRQEA------HELVRQLAMKAFKEGRDLLEVVRK 406
K + E M + EK +G A +E +LA +A+ G + E+ K
Sbjct: 387 CLKGIKANEERMKEYVEKSIGIITAINPHVGYETAAKLAREAYLTGESIRELCIK 441
>gb|AAF46186.2| (AE003438) CG4094 gene product [Drosophila melanogaster]
Length = 408
Score = 69.1 bits (166), Expect = 1e-10
Identities = 85/302 (28%), Positives = 132/302 (43%), Gaps = 33/302 (10%)
Query: 141 DTVCIGRTHGQHAVPTTYGMKFALWLDEIQRHIERLQQLKDRVLVGKMRG-AVGTAAS-- 197
D + IGRTH AVP T G +F+ + ++ ER+ RV + G AVGT +
Sbjct: 125 DIIKIGRTHTMDAVPLTLGQEFSGYAQQLAYAQERIDACLPRVYELALGGTAVGTGLNTR 184
Query: 198 --FGDK-AFEIEKLVMEDLGLKPARITNQIIQRDVYAELMFFLALVASTLDKMALEIRNL 254
F +K A +I +L P + + RD E+ L +A +L K+A +IR L
Sbjct: 185 KGFAEKCAAKIAELTSLPFVTAPNKF-EALAARDAMVEVHGVLNTIAVSLMKIANDIRFL 243
Query: 255 ---QRTEILEVSEPFGEKQVGSSTMPHKRNPIRTEKVCGLARVLYSNVIPALLNNPLWH- 310
R + E+S P E + GSS MP K NP + E + L+ + N + + H
Sbjct: 244 GSGPRCGLGELSLP--ENEPGSSIMPGKVNPTQCESLTMLSAQVMGNQVAVTIGGSNGHF 301
Query: 311 ERDLTNSSVERVILPESFVLLDEMLKVMKKVLKGLEFFPENIKRNLYLTKNLIMAEPLML 370
E ++ + +L +L D + G++ ENI + IM E LML
Sbjct: 302 ELNVFKPLIVSNVLRSIRLLSDGSRTFTANCVNGIQANRENIAK--------IMNESLML 353
Query: 371 KLAEKGMGRQEAHELVRQLAMKAFKEGRDLLEVVRKNEEAMK--YLTENDL-EGLKPENY 427
A + ++ ++A A K G L EEA+ YLTE + ++PE
Sbjct: 354 VTA---LNPHIGYDKAAKIAKTAHKNGTTL------KEEAINLGYLTEQQFNDWVRPEQM 404
Query: 428 IG 429
+G
Sbjct: 405 LG 406
>gi|11428234 similar to argininosuccinate lyase (H. sapiens) [Homo sapiens]
>gi|11434116|ref|XP_007777.1| similar to
argininosuccinate lyase (H. sapiens) [Homo sapiens]
Length = 487
Score = 69.1 bits (166), Expect = 1e-10
Identities = 96/429 (22%), Positives = 184/429 (42%), Gaps = 31/429 (7%)
Query: 2 AVHPIDYRYGSEEM--RRVWEEENKLQKLLD--VEAALARAHAKLGNIPEESARVISERA 57
AV PI ++ + R +WE + + K +E A A++ I +V E A
Sbjct: 39 AVDPIMEKFNASIAYDRHLWEVDVQGSKAYSRGLEKAGLLTKAEMDQILHGLDKVAEEWA 98
Query: 58 NTKWVKLERVKEIEAEIHHDIMAVVKALSEVCGEHGKYVHLGATSNDIIDTANALLIKES 117
+ ++ + +IH A + L E+ G +H G + ND + T L ++++
Sbjct: 99 QGTF----KLNSNDEDIH---TANERRLKELIGATAGKLHTGRSRNDQVVTDLRLWMRQT 151
Query: 118 LAIVEKDLKELRSILKELAKKHIDTVCIGRTHGQHAVPTTYGMKFALWLDEIQRHIERLQ 177
+ + L EL + + A+ D + G TH Q A P + + R ERL
Sbjct: 152 CSTLSGLLWELIRTMVDRAEAERDVLFPGYTHLQRAQPIRWSHWILSHAVALTRDSERLL 211
Query: 178 QLKDRVLVGKMRGAVGTAASFGDKAFEIEKLVMEDLGLKPARITNQ--IIQRDVYAELMF 235
+++ R+ V + G+ A G+ +L+ +L + + +RD AE +F
Sbjct: 212 EVRKRINVLPL----GSGAIAGNPLGVDRELLRAELNFGAITLNSMDATSERDFVAEFLF 267
Query: 236 FLALVASTLDKMA--LEIRNLQRTEILEVSEPFGEKQVGSSTMPHKRNPIRTEKVCGLAR 293
+ +L + L +MA L + + +++S+ + GSS MP K+NP E + A
Sbjct: 268 WASLCMTHLSRMAEDLILYCTKEFSFVQLSDAY---STGSSLMPQKKNPDSLELIRSKAG 324
Query: 294 VLY---SNVIPALLNNPLWHERDLTNSSVERVILPESFVLLDEMLKVMKKVLKGLEFFPE 350
++ + ++ L P + +DL ++ + E + +L+V V+ L+ E
Sbjct: 325 RVFGRCAGLLMTLKGLPSTYNKDLQE---DKEAVFEVSDTMSAVLQVATGVISTLQIHQE 381
Query: 351 NIKRNLYLTKNLIMAEPLMLKLAEKGMGRQEAHELVRQLAMKAFKEGRDLLEVVRKNEEA 410
N+ + L ++A L L KGM ++AHE + A +G L ++ + +
Sbjct: 382 NMGQAL---SPDMLATDLAYYLVRKGMPFRQAHEASGKAVFMAETKGVALNQLSLQELQT 438
Query: 411 MKYLTENDL 419
+ L D+
Sbjct: 439 ISPLFSGDV 447
Database: ./suso.pep
Posted date: Jul 6, 2001 5:57 PM
Number of letters in database: 840,471
Number of sequences in database: 2977
Database: /banques/blast2/nr.pep
Posted date: Dec 14, 2000 12:46 PM
Number of letters in database: 188,266,275
Number of sequences in database: 595,510
Lambda K H
0.318 0.135 0.375
Gapped
Lambda K H
0.270 0.0470 0.230
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 149800203
Number of Sequences: 2977
Number of extensions: 5813202
Number of successful extensions: 22373
Number of sequences better than 1.0e-10: 134
Number of HSP's better than 0.0 without gapping: 40
Number of HSP's successfully gapped in prelim test: 97
Number of HSP's that attempted gapping in prelim test: 22040
Number of HSP's gapped (non-prelim): 141
length of query: 450
length of database: 189,106,746
effective HSP length: 60
effective length of query: 390
effective length of database: 153,197,526
effective search space: 59747035140
effective search space used: 59747035140
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 41 (21.7 bits)
S2: 166 (69.1 bits)