BLASTP 2.0.10 [Aug-26-1999]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= PAB0894 (leuA-3) DE:2-isopropylmalate synthase (leuA-3)
(526 letters)
Database: ./suso.pep; /banques/blast2/nr.pep
598,487 sequences; 189,106,746 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
pir||E75045 2-isopropylmalate synthase (leua-3) PAB0894 - Pyroco... 1045 0.0
sp|O66682|LY41_AQUAE PUTATIVE LYASE AQ_356 >gi|7447064|pir||F703... 645 0.0
sp|Q9WZ22|LY41_THEMA PUTATIVE LYASE TM0552 >gi|7447065|pir||F723... 638 0.0
sp|P74269|LY41_SYNY3 PUTATIVE LYASE SLL1564 >gi|7447061|pir||S75... 535 e-151
gb|AAK40481.1| 2-isopropylmalate synthase, putative (leuA-1) [S... 509 e-143
sp|O86511|LY41_STRCO PUTATIVE LYASE SC1C2.10 >gi|7480336|pir||T2... 499 e-140
emb|CAB60077.1| (Y18874) 2-isopropylmalate synthase [Synechococc... 294 2e-78
sp|Q58787|YD92_METJA PUTATIVE 2-ISOPROPYLMALATE/HOMOCITRATE SYNT... 273 3e-72
gi|11498562 2-isopropylmalate synthase (leuA-1) [Archaeoglobus f... 272 7e-72
pir||D69064 isopropylmalate synthase - Methanobacterium thermoau... 268 1e-70
sp|Q58595|YB95_METJA PUTATIVE 2-ISOPROPYLMALATE/HOMOCITRATE SYNT... 258 9e-68
gi|11497835 2-isopropylmalate synthase (leuA-2) [Archaeoglobus f... 241 1e-62
pir||H69084 2-isopropylmalate synthase - Methanobacterium thermo... 235 1e-60
sp|Q57926|Y503_METJA PUTATIVE 2-ISOPROPYLMALATE/HOMOCITRATE SYNT... 227 3e-58
pir||F69196 2-isopropylmalate synthase - Methanobacterium thermo... 223 4e-57
dbj|BAB06777.1| (AP001517) 2-isopropylmalate synthase [Bacillus ... 217 3e-55
gb|AAK41252.1| 2-isopropylmalate synthase (leuA-2) [Sulfolobus s... 209 7e-53
sp|P94565|LEU1_BACSU 2-ISOPROPYLMALATE SYNTHASE (ALPHA-ISOPROPYL... 207 3e-52
pir||A75045 2-isopropylmalate synthase (leua-1) PAB0890 - Pyroco... 204 2e-51
sp|O67862|LEU1_AQUAE 2-ISOPROPYLMALATE SYNTHASE (ALPHA-ISOPROPYL... 201 1e-50
sp|Q9WZ23|LEU1_THEMA 2-ISOPROPYLMALATE SYNTHASE (ALPHA-ISOPROPYL... 199 8e-50
pir||S40588 hypothetical protein - Escherichia coli >gi|216492|d... 196 5e-49
sp|P09151|LEU1_ECOLI 2-ISOPROPYLMALATE SYNTHASE (ALPHA-ISOPROPYL... 196 5e-49
gi|10954458 2-isopropylmalate synthase [Buchnera aphidicola] >gi... 196 5e-49
pir||B71181 probable 2-isopropylmalate synthase - Pyrococcus hor... 195 9e-49
sp|Q02141|LEU1_LACLA 2-ISOPROPYLMALATE SYNTHASE (ALPHA-ISOPROPYL... 193 3e-48
gb|AAB81913.1| (U92974) LeuA [Lactococcus lactis] 193 3e-48
sp|P94907|LEU1_MICAE 2-ISOPROPYLMALATE SYNTHASE (ALPHA-ISOPROPYL... 190 4e-47
sp|P48576|LEU1_SYNY3 2-ISOPROPYLMALATE SYNTHASE (ALPHA-ISOPROPYL... 189 9e-47
pir||E64106 2-isopropylmalate synthase (EC 4.1.3.12) - Haemophil... 188 2e-46
gi|10954450 isopropylmalate synthase [Buchnera aphidicola] >gi|3... 188 2e-46
sp|P43861|LEU1_HAEIN 2-ISOPROPYLMALATE SYNTHASE (ALPHA-ISOPROPYL... 187 3e-46
emb|CAA07305.2| (AJ006878) 2-isoproylmalate synthase [Buchnera a... 187 3e-46
gi|10957107 2-isopropylmalate synthase [Buchnera sp. APS] >gi|11... 187 3e-46
sp|P48571|LEU1_BUCRP 2-ISOPROPYLMALATE SYNTHASE (ALPHA-ISOPROPYL... 186 6e-46
pir||F82070 2-isopropylmalate synthase VC2490 [imported] - Vibri... 185 1e-45
sp|P48575|LEU1_ANASP 2-ISOPROPYLMALATE SYNTHASE (ALPHA-ISOPROPYL... 180 3e-44
gb|AAK42554.1| 2-isopropylmalate synthase, putative (leuA-3) [S... 179 8e-44
pir||G75159 2-isopropylmalate synthase (leua-2) PAB0286 - Pyroco... 178 1e-43
pir||A82634 2-isopropylmalate synthase XF1818 [imported] - Xylel... 178 2e-43
pir||F75391 2-isopropylmalate synthase - Deinococcus radiodurans... 176 4e-43
pir||G81125 2-isopropylmalate synthase NMB1070 [imported] - Neis... 175 9e-43
pir||C81895 probable 2-isopropylmalate synthase (EC 4.1.3.12) NM... 175 1e-42
gb|AAG31927.1|AF200469_1 (AF200469) 2-isopropylmalate synthase [... 173 6e-42
dbj|BAB08874.1| (AB026660) 2-isopropylmalate synthase-like; homo... 172 7e-42
gb|AAG31395.1| (AF197454) 2-isopropylmaltate synthase [Buchnera ... 172 7e-42
gb|AAG31377.1| (AF197448) 2-isopropylmaltate synthase [Buchnera ... 171 1e-41
gb|AAG31398.1| (AF197455) 2-isopropylmaltate synthase [Buchnera ... 171 2e-41
gb|AAG31401.1| (AF197456) 2-isopropylmaltate synthase [Buchnera ... 169 5e-41
gb|AAG31404.1| (AF197457) 2-isopropylmaltate synthase [Buchnera ... 169 5e-41
gb|AAG31383.1| (AF197450) 2-isopropylmaltate synthase [Buchnera ... 168 1e-40
gb|AAG31389.1| (AF197452) 2-isopropylmaltate synthase [Buchnera ... 168 1e-40
gb|AAG31386.1| (AF197451) 2-isopropylmaltate synthase [Buchnera ... 166 4e-40
gb|AAG31392.1| (AF197453) 2-isopropylmaltate synthase [Buchnera ... 166 4e-40
gb|AAF13763.1|AF117351_20 (AF117351) homocitrate synthase [Zymom... 166 7e-40
sp|O87198|HOSC_THETH HOMOCITRATE SYNTHASE >gi|11268243|pir||T511... 165 1e-39
pir||C81270 2-isopropylmalate synthase (EC 4.1.3.12) Cj1719c [im... 165 1e-39
dbj|BAB09819.1| (AB006708) 2-isopropylmalate synthase-like prote... 163 5e-39
emb|CAB91069.1| (AJ239033) homocitrate sythase 1 [Anabaena varia... 160 3e-38
gb|AAG31926.1|AF200468_1 (AF200468) 2-isopropylmalate synthase [... 157 4e-37
sp|Q12726|HOSM_YARLI HOMOCITRATE SYNTHASE, MITOCHONDRIAL PRECURS... 156 5e-37
emb|CAB91068.1| (AJ239032) homocitrate synthase 2 [Anabaena vari... 156 6e-37
pir||T39279 probable homocitrate synthase (EC 4.1.3.21), mitocho... 155 1e-36
gi|6320071 homocitrate synthase, highly homologous to YDL182W; L... 153 3e-36
gb|AAG27075.1|AF105225_11 (AF105225) NifV [Acetobacter diazotrop... 153 3e-36
gi|6320019 homocitrate synthase, highly homologous to YDL131W; L... 153 3e-36
gb|AAF36732.1| (AC016662) putative 2-isopropylmalate synthase; 3... 152 9e-36
sp|Q39891|LEU1_SOYBN PROBABLE 2-ISOPROPYLMALATE SYNTHASE (ALPHA-... 152 1e-35
sp|O94225|HOSM_PENCH HOMOCITRATE SYNTHASE, MITOCHONDRIAL PRECURS... 151 2e-35
sp|O04973|LU1A_LYCPN 2-ISOPROPYLMALATE SYNTHASE A (ALPHA-ISOPROP... 150 3e-35
sp|P15875|LEU1_SALTY 2-ISOPROPYLMALATE SYNTHASE (ALPHA-ISOPROPYL... 150 5e-35
sp|P54610|NIFV_FRASP HOMOCITRATE SYNTHASE >gi|1280032|gb|AAB3687... 148 1e-34
pir||D75418 homocitrate synthase - Deinococcus radiodurans (stra... 148 1e-34
sp|Q47884|NIFV_FRAAL HOMOCITRATE SYNTHASE >gi|1256029|gb|AAA9626... 147 2e-34
sp|O04974|LU1B_LYCPN 2-ISOPROPYLMALATE SYNTHASE B (ALPHA-ISOPROP... 147 2e-34
gb|AAG31380.1| (AF197449) 2-isopropylmaltate synthase [Buchnera ... 146 5e-34
gb|AAF26002.1|AC013354_21 (AC013354) F15H18.3 [Arabidopsis thali... 143 6e-33
emb|CAA72697.1| (Y11966) 2-isopropylmalate synthase [Buchnera ap... 142 1e-32
pir||S02508 homocitrate synthase (EC 4.1.3.21) - Klebsiella pneu... 136 5e-31
sp|Q07179|NIFV_RHOCA HOMOCITRATE SYNTHASE >gi|486695|pir||S34817... 136 6e-31
sp|P05342|NIFV_AZOVI HOMOCITRATE SYNTHASE >gi|420863|pir||S29758... 136 6e-31
sp|Q56216|LEU1_THETH 2-ISOPROPYLMALATE SYNTHASE (ALPHA-ISOPROPYL... 135 1e-30
gb|AAA22169.1| (M17349) nifV protein [Azotobacter vinelandii] 133 4e-30
sp|Q52070|NIFV_ENTAG HOMOCITRATE SYNTHASE >gi|1480128|emb|CAA680... 133 5e-30
sp|Q01181|NIFV_RHOSH HOMOCITRATE SYNTHASE >gi|282178|pir||D41880... 132 1e-29
sp|P05345|NIFV_KLEPN HOMOCITRATE SYNTHASE >gi|479601|pir||S34848... 131 3e-29
pir||S37297 nifV protein - Klebsiella pneumoniae >gi|149345|gb|A... 130 3e-29
gb|AAF66618.1|AF142777_1 (AF142777) homocitrate synthase [Neuros... 130 3e-29
sp|P23122|NIFV_AZOCH HOMOCITRATE SYNTHASE >gi|280010|pir||C43706... 120 3e-26
emb|CAA91564.1| (Z67750) putative protein [Saccharomyces cerevis... 118 1e-25
pir||C83494 probable 2-isopropylmalate synthase PA1217 [imported... 113 6e-24
sp|P70728|NIFV_AZOBR HOMOCITRATE SYNTHASE >gi|1597740|gb|AAC4617... 106 8e-22
sp|Q44290|NIFV_ANASP HOMOCITRATE SYNTHASE >gi|1487879|emb|CAA681... 105 1e-21
sp|Q00853|NIVA_CLOPA HOMOCITRATE SYNTHASE, ALPHA SUBUNIT >gi|986... 101 2e-20
pir||B70567 probable mhpE protein - Mycobacterium tuberculosis (... 87 5e-16
sp|O31046|LEU1_STRCO 2-ISOPROPYLMALATE SYNTHASE (ALPHA-ISOPROPYL... 87 6e-16
sp|O59736|LEU1_SCHPO 2-ISOPROPYLMALATE SYNTHASE (ALPHA-ISOPROPYL... 84 4e-15
gi|6324225 alpha-isopropylmalate synthase (2-Isopropylmalate Syn... 77 5e-13
gb|AAA34744.1| (M12893) alpha-isopropylmalate synthase (EC 4.1.3... 77 5e-13
sp|Q9X7L2|LEU1_RHIME 2-ISOPROPYLMALATE SYNTHASE (ALPHA-ISOPROPYL... 76 9e-13
emb|CAB69749.1| (AL137166) 2-ispoprylmalate synthase [Streptomyc... 76 9e-13
emb|CAB39977.1| (AJ132004) 2-isopropylmalate synthase [Sinorhizo... 76 1e-12
sp|Q51983|CMTG_PSEPU 4-HYDROXY-2-OXOVALERATE ALDOLASE (HOA) >gi|... 76 1e-12
sp|Q00852|NIVO_CLOPA HOMOCITRATE SYNTHASE, OMEGA SUBUNIT >gi|986... 75 2e-12
emb|CAA19166.1| (AL023596) 2-isopropylmalate synthase [Mycobacte... 73 6e-12
dbj|BAA90528.1| (AB029822) 2-phosphinomethylmalic acid synthase ... 73 1e-11
sp|P51020|MHPE_ECOLI 4-HYDROXY-2-OXOVALERATE ALDOLASE (HOA) >gi|... 72 2e-11
sp|P51014|BPHF_PSES1 4-HYDROXY-2-OXOVALERATE ALDOLASE (HOA) >gi|... 70 5e-11
dbj|BAA82884.1| (AB024335) 4-hydroxy-2-ketovalerate aldolase [Co... 69 9e-11
>pir||E75045 2-isopropylmalate synthase (leua-3) PAB0894 - Pyrococcus abyssi
(strain Orsay) >gi|5458771|emb|CAB50258.1| (AJ248287)
2-isopropylmalate synthase (leuA-3) [Pyrococcus abyssi]
Length = 526
Score = 1045 bits (2672), Expect = 0.0
Identities = 526/526 (100%), Positives = 526/526 (100%)
Query: 1 MLMKRRVELYDTTLRDGSQMEGISFSLEDKLKITEKLDEFGIHYIEGGWPGSNPKDIQYF 60
MLMKRRVELYDTTLRDGSQMEGISFSLEDKLKITEKLDEFGIHYIEGGWPGSNPKDIQYF
Sbjct: 1 MLMKRRVELYDTTLRDGSQMEGISFSLEDKLKITEKLDEFGIHYIEGGWPGSNPKDIQYF 60
Query: 61 KAVRDLPLENAKIAAFGSTRRPRLRPEEDPNLNALVESEAPIATIFGKSWDLHVTEALRT 120
KAVRDLPLENAKIAAFGSTRRPRLRPEEDPNLNALVESEAPIATIFGKSWDLHVTEALRT
Sbjct: 61 KAVRDLPLENAKIAAFGSTRRPRLRPEEDPNLNALVESEAPIATIFGKSWDLHVTEALRT 120
Query: 121 TLENNIQMIIDSIEYLRDHGMVVFYDAEHFFDGYRENPEYAMKTIKAAEEAGAERIVLAD 180
TLENNIQMIIDSIEYLRDHGMVVFYDAEHFFDGYRENPEYAMKTIKAAEEAGAERIVLAD
Sbjct: 121 TLENNIQMIIDSIEYLRDHGMVVFYDAEHFFDGYRENPEYAMKTIKAAEEAGAERIVLAD 180
Query: 181 TNGGSLPSFIKEVVEKVKEEVKTPLGIHAHNDSELAVANSLIAFEAGVVQIQGTINGYGE 240
TNGGSLPSFIKEVVEKVKEEVKTPLGIHAHNDSELAVANSLIAFEAGVVQIQGTINGYGE
Sbjct: 181 TNGGSLPSFIKEVVEKVKEEVKTPLGIHAHNDSELAVANSLIAFEAGVVQIQGTINGYGE 240
Query: 241 RCGNANLISIIPALELKYGVEVVGKERLRKLKELAHFVAELANMEIPRNQPYVGDSAFAH 300
RCGNANLISIIPALELKYGVEVVGKERLRKLKELAHFVAELANMEIPRNQPYVGDSAFAH
Sbjct: 241 RCGNANLISIIPALELKYGVEVVGKERLRKLKELAHFVAELANMEIPRNQPYVGDSAFAH 300
Query: 301 KGGVHVSAVLKNPRTYEHIDPELVGNRRKVVVSELSGRSNLIYKAKELGIELEERDIKRI 360
KGGVHVSAVLKNPRTYEHIDPELVGNRRKVVVSELSGRSNLIYKAKELGIELEERDIKRI
Sbjct: 301 KGGVHVSAVLKNPRTYEHIDPELVGNRRKVVVSELSGRSNLIYKAKELGIELEERDIKRI 360
Query: 361 VEEIKKLEFEGYHFEAAEASLELLIERLRGRYKPFFELERARVITEIFQGQPPISEANVV 420
VEEIKKLEFEGYHFEAAEASLELLIERLRGRYKPFFELERARVITEIFQGQPPISEANVV
Sbjct: 361 VEEIKKLEFEGYHFEAAEASLELLIERLRGRYKPFFELERARVITEIFQGQPPISEANVV 420
Query: 421 VRVNSRRVHTTAEGNGPVNALDLALRKALTKFYPELKEIKLVDYKVRVLGSEKGTAAKVR 480
VRVNSRRVHTTAEGNGPVNALDLALRKALTKFYPELKEIKLVDYKVRVLGSEKGTAAKVR
Sbjct: 421 VRVNSRRVHTTAEGNGPVNALDLALRKALTKFYPELKEIKLVDYKVRVLGSEKGTAAKVR 480
Query: 481 VLVQTSDGKKTWGTVGASTNIIEASLNAIMESMEYWLMKEREKDEK 526
VLVQTSDGKKTWGTVGASTNIIEASLNAIMESMEYWLMKEREKDEK
Sbjct: 481 VLVQTSDGKKTWGTVGASTNIIEASLNAIMESMEYWLMKEREKDEK 526
>sp|O66682|LY41_AQUAE PUTATIVE LYASE AQ_356 >gi|7447064|pir||F70331 2-isopropylmalate
synthase - Aquifex aeolicus >gi|2983027|gb|AAC06637.1|
(AE000685) 2-isopropylmalate synthase [Aquifex aeolicus]
Length = 528
Score = 645 bits (1645), Expect = 0.0
Identities = 313/525 (59%), Positives = 411/525 (77%), Gaps = 4/525 (0%)
Query: 3 MKRRVELYDTTLRDGSQMEGISFSLEDKLKITEKLDEFGIHYIEGGWPGSNPKDIQYFKA 62
M +V +YDTTLRDGSQMEG+SFSLEDK++I EKLD+FGIHYIEGGWP +NPKD +F+
Sbjct: 1 MAEKVYIYDTTLRDGSQMEGVSFSLEDKIRIAEKLDDFGIHYIEGGWPYANPKDNLFFQK 60
Query: 63 VRDLPLENAKIAAFGSTRRPRLRPEEDPNLNALVESEAPIATIFGKSWDLHVTEALRTTL 122
+ + +NAK+ AFGSTRRP + EDP + +L+++E P+ TIFGKSWDLHVT+AL+TTL
Sbjct: 61 AKKMNFKNAKLTAFGSTRRPNKKVSEDPQVESLIKAETPVVTIFGKSWDLHVTDALKTTL 120
Query: 123 ENNIQMIIDSIEYLRDHGMVVFYDAEHFFDGYRENPEYAMKTIKAAEEAGAERIVLADTN 182
E N+ MI +++EYL+ + V +DAEHFFDGY+ NPEYA++ ++AA + GA+ +VL DTN
Sbjct: 121 EENLNMIYETVEYLKRYVDEVIFDAEHFFDGYKSNPEYALQVLEAALKGGADWVVLCDTN 180
Query: 183 GGSLPSFIKEVVEKVKEEVK-TPLGIHAHNDSELAVANSLIAFEAGVVQIQGTINGYGER 241
GG+LP I E+ +KVKE K +GIHAHNDSE AVANSL+A AG Q+ GTING GER
Sbjct: 181 GGTLPHEIYEITKKVKERFKDANVGIHAHNDSETAVANSLMAVLAGARQVHGTINGIGER 240
Query: 242 CGNANLISIIPALELKYGVEVVGKERLRKLKELAHFVAELANMEIPRNQPYVGDSAFAHK 301
GNANL SIIP L+LK G +V+ +E L+KL ELA+FVAE+ NM +PRN PYVG+SAFAHK
Sbjct: 241 TGNANLCSIIPNLQLKLGFDVIPQENLKKLTELANFVAEIINMPLPRNMPYVGESAFAHK 300
Query: 302 GGVHVSAVLKNPRTYEHIDPELVGNRRKVVVSELSGRSNLIYKAKELGIELEER--DIKR 359
GGVH SAVLKN +TYEHI+PELVGN+RK+ VS+L+GRSNL++K KE GIE++ + ++K+
Sbjct: 301 GGVHASAVLKNAKTYEHINPELVGNKRKITVSDLAGRSNLVHKLKEFGIEIDPKSPELKK 360
Query: 360 IVEEIKKLEFEGYHFEAAEASLELLIERLRGRYKPFFELERARV-ITEIFQGQPPISEAN 418
++++IK+LE EGYHFEAAEASLELLI+R G K +F+ + RV I + P SEA
Sbjct: 361 LIDKIKELEKEGYHFEAAEASLELLIKRHFGLVKDYFDFDAYRVLIAKRRDDSLPTSEAT 420
Query: 419 VVVRVNSRRVHTTAEGNGPVNALDLALRKALTKFYPELKEIKLVDYKVRVLGSEKGTAAK 478
V + V HT + GNGP++ALD ALRKAL +FYP LKE++L+DYKVR++ GT+AK
Sbjct: 421 VRLSVEGVEEHTASLGNGPISALDRALRKALEEFYPNLKELQLIDYKVRIINESAGTSAK 480
Query: 479 VRVLVQTSDGKKTWGTVGASTNIIEASLNAIMESMEYWLMKEREK 523
VRVL++++DGK+ WGTVG S N+IEAS A+ +S+ Y LMK+ E+
Sbjct: 481 VRVLIESTDGKRKWGTVGVSENVIEASWIALRDSIVYKLMKDEEE 525
>sp|Q9WZ22|LY41_THEMA PUTATIVE LYASE TM0552 >gi|7447065|pir||F72362 hypothetical protein
TM0552 - Thermotoga maritima (strain MSB8)
>gi|4981067|gb|AAD35637.1|AE001730_5 (AE001730)
2-isopropylmalate synthase, putative [Thermotoga
maritima]
Length = 538
Score = 638 bits (1627), Expect = 0.0
Identities = 312/529 (58%), Positives = 403/529 (75%), Gaps = 12/529 (2%)
Query: 7 VELYDTTLRDGSQMEGISFSLEDKLKITEKLDEFGIHYIEGGWPGSNPKDIQYFKAVRDL 66
+++YDTTLRDG+Q G+SFSLEDK++I E LD+ G+HY+EGGWPGSNPKDI +F+AV+ +
Sbjct: 3 IKVYDTTLRDGAQAFGVSFSLEDKIRIAEALDDLGVHYLEGGWPGSNPKDIAFFEAVKGM 62
Query: 67 PLENAKIAAFGSTRRPRLRPEEDPNLNALVESEAPIATIFGKSWDLHVTEALRTTLENNI 126
+N K+AAF STRRP ++ EED N+ L+++E P+ TIFGKSWDLHV +ALRTTLE N+
Sbjct: 63 NFKNLKVAAFSSTRRPDVKIEEDANIQTLIKAETPVYTIFGKSWDLHVEKALRTTLEENL 122
Query: 127 QMIIDSIEYLRDHGMVVFYDAEHFFDGYRENPEYAMKTIKAAEEAGAERIVLADTNGGSL 186
+MI D++ YL+ V YDAEHFFDGY+ N EYA+KT+K AEEAGA+ +VLADTNGG+L
Sbjct: 123 KMIYDTVSYLKRFADEVIYDAEHFFDGYKANREYALKTLKVAEEAGADCLVLADTNGGTL 182
Query: 187 PSFIKEVVEKVKEEVKTPLGIHAHNDSELAVANSLIAFEAGVVQIQGTINGYGERCGNAN 246
P I+E++E VK+ VK PLGIHAHNDS++AVAN+L A G V +QGTING GERCGNAN
Sbjct: 183 PHEIEEIIEDVKKHVKAPLGIHAHNDSDVAVANTLAAVRKGAVHVQGTINGLGERCGNAN 242
Query: 247 LISIIPALELKYGVEVVGKERLRKLKELAHFVAELANMEIPRNQPYVGDSAFAHKGGVHV 306
L S+IP L LK G+EV+ KE L+KL ++AH VAEL+ N PYVGD AFAHKGGVHV
Sbjct: 243 LCSVIPNLVLKMGLEVIPKENLKKLFDVAHLVAELSGRPHIENMPYVGDYAFAHKGGVHV 302
Query: 307 SAVLKNPRTYEHIDPELVGNRRKVVVSELSGRSNLIYKAKELGIELEERD--IKRIVEEI 364
SA+ ++PRTYEHIDPELVGNRR + +SELSG+SN++ K KE+G E++E ++ I+++I
Sbjct: 303 SAIKRDPRTYEHIDPELVGNRRIISISELSGKSNVLEKIKEMGFEIDESSPKVREILKKI 362
Query: 365 KKLEFEGYHFEAAEASLELLIERLRGRYKPFFELERARVITEIFQGQPPISEANVVVRVN 424
K+LE +GYHFE AEAS ELL+ + G+ K +FE V+T + + SEA V VRV
Sbjct: 363 KELEAQGYHFEGAEASFELLVRDMLGKRKKYFEFLGFTVMTIKNRDEESFSEATVKVRVP 422
Query: 425 ---SRRV-------HTTAEGNGPVNALDLALRKALTKFYPELKEIKLVDYKVRVLGSEKG 474
++R+ HT AEG GPV ALD A+RKAL KFYP LK+ KL DYKVR+L + G
Sbjct: 423 DEVAKRLGHDEPFEHTAAEGEGPVEALDRAVRKALEKFYPSLKDTKLTDYKVRILNEQAG 482
Query: 475 TAAKVRVLVQTSDGKKTWGTVGASTNIIEASLNAIMESMEYWLMKEREK 523
T A RVL+++SDGK+ WGTVG S NIIEAS A++ES+EY L K+ E+
Sbjct: 483 TKATTRVLIESSDGKRRWGTVGVSPNIIEASWTALLESLEYKLHKDEEE 531
>sp|P74269|LY41_SYNY3 PUTATIVE LYASE SLL1564 >gi|7447061|pir||S75904 hypothetical protein
- Synechocystis sp. (strain PCC 6803)
>gi|1653449|dbj|BAA18363.1| (D90913)
alpha-isopropylmalate synthase [Synechocystis sp.]
Length = 547
Score = 535 bits (1363), Expect = e-151
Identities = 275/528 (52%), Positives = 364/528 (68%), Gaps = 14/528 (2%)
Query: 4 KRRVELYDTTLRDGSQMEGISFSLEDKLKITEKLDEFGIHYIEGGWPGSNPKDIQYFKAV 63
K + LYDTTLRDG+Q EGIS SL DKL I +LD+ GI +IEGGWPG+NPKD+Q+F +
Sbjct: 5 KTSLWLYDTTLRDGAQREGISLSLTDKLTIARRLDQLGIPFIEGGWPGANPKDVQFFWQL 64
Query: 64 RDLPLENAKIAAFGSTRRPRLRPEEDPNLNALVESEAPIATIFGKSWDLHVTEALRTTLE 123
++ PLE A+I AF STRRP E D L A++ + TIFGKSWDLHV E L+T+L
Sbjct: 65 QEEPLEQAEIVAFCSTRRPHKAVETDKMLQAILSAGTRWVTIFGKSWDLHVLEGLQTSLA 124
Query: 124 NNIQMIIDSIEYLRDHGMVVFYDAEHFFDGYRENPEYAMKTIKAAEEAGAERIVLADTNG 183
N+ MI D+I YLR G V YDAEH+FDGYR NP+YA+ T+ A++AGAE +V+ DTNG
Sbjct: 125 ENLAMISDTIAYLRSQGRRVIYDAEHWFDGYRANPDYALATLATAQQAGAEWLVMCDTNG 184
Query: 184 GSLPSFIKEVVEKVKEEV--------KTPLGIHAHNDSELAVANSLIAFEAGVVQIQGTI 235
G+LP I E+ KV+ + + LGIHAHNDS AVANSL+A EAG +QGTI
Sbjct: 185 GTLPGQISEITTKVRRSLGLDGQSDRQPQLGIHAHNDSGTAVANSLLAVEAGATMVQGTI 244
Query: 236 NGYGERCGNANLISIIPALELKYGVEVVGKERLRKLKELAHFVAELANMEIPRNQPYVGD 295
NGYGERCGNANL ++IP L+LK + + E+L L + ++E+ N+ + P+VG
Sbjct: 245 NGYGERCGNANLCTLIPNLQLKLDYDCIEPEKLAHLTSTSRLISEIVNLAPDDHAPFVGR 304
Query: 296 SAFAHKGGVHVSAVLKNPRTYEHIDPELVGNRRKVVVSELSGRSNLIYKAKELGIELEER 355
SAFAHKGG+HVSAV +NP TYEHI P LVGN R++VVSE +G SN++ KA+ GI L+ +
Sbjct: 305 SAFAHKGGIHVSAVQRNPFTYEHIAPNLVGNERRIVVSEQAGLSNVLSKAELFGIALDRQ 364
Query: 356 D--IKRIVEEIKKLEFEGYHFEAAEASLELLIERLRGRYKPFFELERARVITEIF-QGQP 412
+ + I+ +K LE +GY FEAAEAS ELL+ + G +P F ++ +V ++ +
Sbjct: 365 NPACRTILATLKDLEQQGYQFEAAEASFELLMRQAMGDRQPLFLVQGFQVHCDLLTPAEN 424
Query: 413 PI---SEANVVVRVNSRRVHTTAEGNGPVNALDLALRKALTKFYPELKEIKLVDYKVRVL 469
P + A V V VN + + AEGNGPV+ALD ALRKALT+FYP++ + L DYKVR+L
Sbjct: 425 PAYRNALATVKVTVNGQNILEVAEGNGPVSALDQALRKALTRFYPQIADFHLTDYKVRIL 484
Query: 470 GSEKGTAAKVRVLVQTSDGKKTWGTVGASTNIIEASLNAIMESMEYWL 517
GT+AK RVLV++S+G + W TVG S NI+EAS A++E +EY L
Sbjct: 485 DGGAGTSAKTRVLVESSNGDRRWTTVGVSGNILEASYQAVVEGIEYGL 532
>gb|AAK40481.1| 2-isopropylmalate synthase, putative (leuA-1) [Sulfolobus
solfataricus]
Length = 553
Score = 509 bits (1297), Expect = e-143
Identities = 259/521 (49%), Positives = 363/521 (68%), Gaps = 11/521 (2%)
Query: 4 KRRVELYDTTLRDGSQMEGISFSLEDKLKITEKLDEFGIHYIEGGWPGSNPKDIQYFKAV 63
K+ VE+ DTTLRDGSQ ISF+L DK+KI LDE G+ YIEGGWPGSNPKD ++F+ +
Sbjct: 30 KKSVEVLDTTLRDGSQGANISFTLNDKIKIALLLDELGVDYIEGGWPGSNPKDEEFFREI 89
Query: 64 RDLPLENAKIAAFGSTRRPRLRPEEDPNLNALVESEAPIATIFGKSWDLHVTEALRTTLE 123
+ L AKIAAFGST+R + +ED +LN++V+++ +A IFGKSW LH TE L+ T +
Sbjct: 90 KKYRLSKAKIAAFGSTKRKDVSVKEDISLNSIVKADVDVAVIFGKSWSLHATEVLKVTKQ 149
Query: 124 NNIQMIIDSIEYLRDHGMVVFYDAEHFFDGYRENPEYAMKTIKAAEEAGAERIVLADTNG 183
+N+ ++ DSI YL+ HG+ V +DAEHF+ G++E+PEYA++ +K AE AGA+ I LADTNG
Sbjct: 150 DNLDIVYDSINYLKSHGLKVIFDAEHFYQGFKEDPEYALEVVKTAESAGADVIALADTNG 209
Query: 184 GSLPSFIKEVVEKVKEEVKTPLGIHAHNDSELAVANSLIAFEAGVVQIQGTINGYGERCG 243
G+ P + E+ +KV+E ++ LGIHAHND AVANSL+A +AG +QGTING GER G
Sbjct: 210 GTPPFEVYEITKKVREVLQVKLGIHAHNDIGCAVANSLMAIKAGARHVQGTINGIGERTG 269
Query: 244 NANLISIIPALELKYGVEVV-GKERLRKLKELAHFVAELANMEIPRNQPYVGDSAFAHKG 302
NA+LI IIP L LK G+ + G+E LRKL+E++ V E+ + QPYVGD+AFAHK
Sbjct: 270 NADLIQIIPTLILKMGLNALNGQESLRKLREVSRIVYEILGLPPNPYQPYVGDNAFAHKA 329
Query: 303 GVHVSAVLKNPRTYEHIDPELVGNRRKVVVSELSGRSNLIYKAKELGIELEERD--IKRI 360
GVHV AV+K PR YEH+DP LVGN RK V+SELSG +NL+ + LGI ++++D +K+
Sbjct: 330 GVHVDAVMKVPRAYEHVDPSLVGNDRKFVISELSGTANLVSYLQGLGIAVDKKDERLKKA 389
Query: 361 VEEIKKLEFEGYHFEAAEASLELLIERLRGRYKPFFELERARVITEIFQGQPPISEANVV 420
+ +IK+LE GY F+ AS L+ + YK + LE +VI E +S +
Sbjct: 390 LNKIKELEARGYSFDVGPASAILITLKELNIYKNYINLEYWKVINE----NNGLSIG--I 443
Query: 421 VRVNSRRVHTTAEGNGPVNALDLALRKALTKFYPELKEIKLVDYKVRVLGSEKGTAAKVR 480
V+VNS+ AEG GPVNA+D ALR AL + YPE+ E+KL+DY+V + K T + VR
Sbjct: 444 VKVNSQL--EVAEGVGPVNAIDRALRMALQRVYPEIGEVKLIDYRVILPSEIKNTESVVR 501
Query: 481 VLVQTSDGKKTWGTVGASTNIIEASLNAIMESMEYWLMKER 521
V ++ +D K W T G S +++EAS+ A+++ ++Y+L ++
Sbjct: 502 VTIEFTDNKMNWRTEGVSKSVVEASVMALVDGLDYYLQLKK 542
>sp|O86511|LY41_STRCO PUTATIVE LYASE SC1C2.10 >gi|7480336|pir||T29059 probable
2-isopropylmalate synthase (EC 4.1.3.12) - Streptomyces
coelicolor >gi|3355677|emb|CAA19977.1| (AL031124)
putative lyase [Streptomyces coelicolor A3(2)]
Length = 534
Score = 499 bits (1271), Expect = e-140
Identities = 252/515 (48%), Positives = 350/515 (67%), Gaps = 4/515 (0%)
Query: 9 LYDTTLRDGSQMEGISFSLEDKLKITEKLDEFGIHYIEGGWPGSNPKDIQYF-KAVRDLP 67
++DTTLRDG+Q EGI+ ++ DKL I LD+FG+ +IEGGWPG+NP+D ++F +A +++
Sbjct: 13 VFDTTLRDGAQREGINLTVADKLAIARHLDDFGVGFIEGGWPGANPRDTEFFARARQEID 72
Query: 68 LENAKIAAFGSTRRPRLRPEEDPNLNALVESEAPIATIFGKSWDLHVTEALRTTLENNIQ 127
++A++ AFGSTRR ED + AL++S A + T+ KS D HV ALRTTL+ N+
Sbjct: 73 FKHAQLVAFGSTRRAGANAAEDHQVKALLDSGAQVITLVAKSHDRHVELALRTTLDENLA 132
Query: 128 MIIDSIEYLRDHGMVVFYDAEHFFDGYRENPEYAMKTIKAAEEAGAERIVLADTNGGSLP 187
M+ D++ +L+ G VF D EHFFDGYR NPEYA ++ A EAGA+ +VL DTNGG LP
Sbjct: 133 MVADTVSHLKAQGRRVFVDCEHFFDGYRANPEYAKSVVRTASEAGADVVVLCDTNGGMLP 192
Query: 188 SFIKEVVEKVKEEVKTPLGIHAHNDSELAVANSLIAFEAGVVQIQGTINGYGERCGNANL 247
+ I+ VV V + LGIHA +D+ AVAN+L A +AG +Q T NGYGER GNANL
Sbjct: 193 AQIQAVVATVLADTGARLGIHAQDDTGCAVANTLAAVDAGATHVQCTANGYGERVGNANL 252
Query: 248 ISIIPALELKYGVEVVGKERLRKLKELAHFVAELANMEIPRNQPYVGDSAFAHKGGVHVS 307
++ ALELKYG +V+ + RLR++ ++H +AE+ N+ +QPYVG SAFAHK G+H S
Sbjct: 253 FPVVAALELKYGKQVLPEGRLREMTRISHAIAEVVNLTPSTHQPYVGVSAFAHKAGLHAS 312
Query: 308 AVLKNPRTYEHIDPELVGNRRKVVVSELSGRSNLIYKAKELGIEL--EERDIKRIVEEIK 365
A+ +P Y+HIDPELVGN +++VS+++GR+++ K KELGI+L + + R+VE +K
Sbjct: 313 AIKVDPDLYQHIDPELVGNTMRMLVSDMAGRASIELKGKELGIDLGGDRELVGRVVERVK 372
Query: 366 KLEFEGYHFEAAEASLELLIE-RLRGRYKPFFELERARVITEIFQGQPPISEANVVVRVN 424
+ E GY +EAA+AS ELL+ GR +FE+E R ITE +EA V +
Sbjct: 373 ERELAGYTYEAADASFELLLRAEAEGRPLKYFEVESWRAITEDRPDGSHANEATVKLWAK 432
Query: 425 SRRVHTTAEGNGPVNALDLALRKALTKFYPELKEIKLVDYKVRVLGSEKGTAAKVRVLVQ 484
R+ TAEGNGPVNALD +LR AL K YPEL ++ LVDYKVR+L GT + RVL+
Sbjct: 433 GERIVATAEGNGPVNALDRSLRVALEKIYPELAKLDLVDYKVRILEGVHGTQSTTRVLIS 492
Query: 485 TSDGKKTWGTVGASTNIIEASLNAIMESMEYWLMK 519
TSDG W TVG + N+I AS A+ ++ Y L++
Sbjct: 493 TSDGTGEWATVGVAENVIAASWQALEDAYTYGLLR 527
>emb|CAB60077.1| (Y18874) 2-isopropylmalate synthase [Synechococcus PCC6301]
Length = 268
Score = 294 bits (744), Expect = 2e-78
Identities = 147/259 (56%), Positives = 182/259 (69%), Gaps = 8/259 (3%)
Query: 7 VELYDTTLRDGSQMEGISFSLEDKLKITEKLDEFGIHYIEGGWPGSNPKDIQYFKAVRDL 66
+ +YDTTLRDG+Q EG+S SLEDKL+I LD G+ +IEGGWPG+NPKD+Q+F ++
Sbjct: 9 IAVYDTTLRDGAQREGLSLSLEDKLRIAHCLDRLGVKFIEGGWPGANPKDVQFFWELQQR 68
Query: 67 PLENAKIAAFGSTRRPRLRPEEDPNLNALVESEAPIATIFGKSWDLHVTEALRTTLENNI 126
PL+ A++ AF STRRP ED L AL+ + TIFGKSWDLHV E L+T+L+ N+
Sbjct: 69 PLQQAEVVAFCSTRRPGQIAGEDELLKALLAAGTTWVTIFGKSWDLHVVEGLKTSLDENL 128
Query: 127 QMIIDSIEYLRDHGMVVFYDAEHFFDGYRENPEYAMKTIKAAEEAGAERIVLADTNGGSL 186
MI DSI YLR V YDAEH+FDGY NP+YA++T+ AA EAGAE IVL DTNGG L
Sbjct: 129 VMISDSIAYLRTCDRRVIYDAEHWFDGYLANPDYALQTLAAAIEAGAEWIVLCDTNGGCL 188
Query: 187 PSFIKEVVEKV--------KEEVKTPLGIHAHNDSELAVANSLIAFEAGVVQIQGTINGY 238
P I E+V V ++ LGIH HNDSE AVAN++ A +AG + GTINGY
Sbjct: 189 PHQISEIVAAVLDRFPSLAPDQTGPQLGIHTHNDSETAVANAIAAVQAGARMVHGTINGY 248
Query: 239 GERCGNANLISIIPALELK 257
GERCGNANL S+IP L+LK
Sbjct: 249 GERCGNANLCSVIPNLQLK 267
>sp|Q58787|YD92_METJA PUTATIVE 2-ISOPROPYLMALATE/HOMOCITRATE SYNTHASE MJ1392
>gi|2127716|pir||G64473 2-isopropylmalate synthase (EC
4.1.3.12) - Methanococcus jannaschii
>gi|1592039|gb|AAB99402.1| (U67579) 2-isopropylmalate
synthase (leuA) [Methanococcus jannaschii]
Length = 491
Score = 273 bits (691), Expect = 3e-72
Identities = 168/512 (32%), Positives = 282/512 (54%), Gaps = 25/512 (4%)
Query: 7 VELYDTTLRDGSQMEGISFSLEDKLKITEKLDEFGIHYIEGGWPGSNPKDIQYFKAVRDL 66
V ++DTTLRDG Q G+S + DKL+I +KLDE G+ IE G ++ + + K +
Sbjct: 3 VRIFDTTLRDGEQTPGVSLTPNDKLEIAKKLDELGVDVIEAGSAITSKGEREGIKLITKE 62
Query: 67 PLENAKIAAFGSTRRPRLRPEEDPNLNALVESEAPIATIFGKSWDLHVTEALRTTLENNI 126
L NA+I +F R P + ++A +E + + + +H+ LR T + +
Sbjct: 63 GL-NAEICSF-----VRALPVD---IDAALECDVDSVHLVVPTSPIHMKYKLRKTEDEVL 113
Query: 127 QMIIDSIEYLRDHGMVVFYDAEHFFDGYRENPEYAMKTIKAAEEAGAERIVLADTNGGSL 186
+ + ++EY ++HG++V AE D R + + +K E+ GA+R+ + DT G
Sbjct: 114 ETALKAVEYAKEHGLIVELSAE---DATRSDVNFLIKLFNEGEKVGADRVCVCDTVGVLT 170
Query: 187 PSFIKEVVEKVKEEVKTPLGIHAHNDSELAVANSLIAFEAGVVQIQGTINGYGERCGNAN 246
P +E+ +K+ E V P+ +H HND +A AN+ A G VQ T+NG GER GNA+
Sbjct: 171 PQKSQELFKKITENVNLPVSVHCHNDFGMATANTCSAVLGGAVQCHVTVNGIGERAGNAS 230
Query: 247 LISIIPALELKYGVEVVGKERLRKLKELAHFVAELANMEIPRNQPYVGDSAFAHKGGVHV 306
L ++ AL++ YG + K ++ KL E++ V+ L + +P N+ VGD+AFAH+ G+HV
Sbjct: 231 LEEVVAALKILYGYDT--KIKMEKLYEVSRIVSRLMKLPVPPNKAIVGDNAFAHEAGIHV 288
Query: 307 SAVLKNPRTYEHIDPELVGNRRKVVVSELSGRSNLIYKAKELGIELEERDIKRIVEEIKK 366
++KN TYE I PE+VGNRR++++ + SGR L YK +GI + + + +I E +K
Sbjct: 289 DGLIKNTETYEPIKPEMVGNRRRIILGKHSGRKALKYKLDLMGINVSDEQLNKIYERVK- 347
Query: 367 LEFEGYHFEAAEASLELLIERLRGR-YKPFFELERARVITEIFQGQPPISEANVVVRVNS 425
EF ++A L ++ + G+ + +L+ V++ PI+ + +
Sbjct: 348 -EFGDLGKYISDADLLAIVREVTGKLVEEKIKLDELTVVSG--NKITPIASVKLHYKGED 404
Query: 426 RRVHTTAEGNGPVNALDLALRKALTKFYPELKEIKLVDYKVRVLGSEKGTAAKVRVLVQT 485
+ TA G GPV+A A+RKA++ + +IKLV+Y+V +G GT A + V+V+
Sbjct: 405 ITLIETAYGVGPVDAAINAVRKAIS----GVADIKLVEYRVEAIGG--GTDALIEVVVKL 458
Query: 486 SDGKKTWGTVGASTNIIEASLNAIMESMEYWL 517
G + + +II AS++A+ME + L
Sbjct: 459 RKGTEIVEVRKSDADIIRASVDAVMEGINMLL 490
>gi|11498562 2-isopropylmalate synthase (leuA-1) [Archaeoglobus fulgidus]
>gi|7447057|pir||E69369 2-isopropylmalate synthase
(leuA-1) homolog - Archaeoglobus fulgidus
>gi|2649641|gb|AAB90286.1| (AE001038) 2-isopropylmalate
synthase (leuA-1) [Archaeoglobus fulgidus]
Length = 489
Score = 272 bits (688), Expect = 7e-72
Identities = 174/514 (33%), Positives = 285/514 (54%), Gaps = 36/514 (7%)
Query: 6 RVELYDTTLRDGSQMEGISFSLEDKLKITEKLDEFGIHYIEGGWPGSNPKDIQYFKAVRD 65
+V++ DTTLRDG Q G+S S+E K+ I E LD G+ IE G ++ D Q K +
Sbjct: 2 QVKILDTTLRDGEQTPGVSLSVEQKVMIAEALDNLGVDIIEAGTAIASEGDFQAIKEISQ 61
Query: 66 LPLENAKIAAFGSTRRPRLRPEEDPNLNALVESEAPIATIFGKSWDLHVTEALR-TTLEN 124
L NA+I +F +R +++A ++ A + S D+H+ +
Sbjct: 62 RGL-NAEICSFARIKRE--------DIDAAADAGAESIFMVAPSSDIHINAKFPGKDRDY 112
Query: 125 NIQMIIDSIEYLRDHGMVVFYDAEHFFDGYRENPEYAMKTIKAAEEAGAERIVLADTNGG 184
I+ +++IEY ++ G++V + AE D R + ++ ++ K AEEA A+RI ADT G
Sbjct: 113 VIEKSVEAIEYAKERGLIVEFGAE---DASRADLDFVIQLFKRAEEAKADRITFADTVGV 169
Query: 185 SLPSFIKEVVEKVKEEVKTPLGIHAHNDSELAVANSLIAFEAGVVQIQGTINGYGERCGN 244
P ++E+V K+K +VK PL IH H+D LA AN++ +AG + GTING GER GN
Sbjct: 170 LSPEKMEEIVRKIKAKVKLPLAIHCHDDFGLATANTIFGIKAGAEEFHGTINGLGERAGN 229
Query: 245 ANLISIIPALELKYGVEV-VGKERLRKLKELAHFVAELANMEIPRNQPYVGDSAFAHKGG 303
A + ++ ALE YG++ + KERL +L V +L+ + +P N+P VGD+AF H+ G
Sbjct: 230 AAIEEVVIALEYLYGIKTKIKKERLYNTSKL---VEKLSRVVVPPNKPIVGDNAFTHESG 286
Query: 304 VHVSAVLKNPRTYEHIDPELVGNRRKVVVSELSGRSNLIYKAKELGIELEERDIKRIVEE 363
+H SA+ ++ ++YE I PE+VG +R +V+ + +GR+++ ELG + +K I+
Sbjct: 287 IHTSALFRDAKSYEPISPEVVGRKRVIVLGKHAGRASVEAIMNELGYKATPEQMKEILAR 346
Query: 364 IKKLEFEGYHFEAAEASLELLIERLRGRYKPFFELERARVI----TEIFQGQPPISEANV 419
IK++ +G +A + +IE + +++R + + IF G+ + A+V
Sbjct: 347 IKEIGDKGK--RVTDADVRTIIETV-------LQIKREKKVKLEDLAIFSGKNVMPMASV 397
Query: 420 VVRVNSRRVHTTAEGNGPVNALDLALRKALTKFYPELKEIKLVDYKVRVLGSEKGTAAKV 479
++++ + A G GPV+A A+R+A+ +F +IKLV Y V + GT A V
Sbjct: 398 KLKIDGQERIEAAVGLGPVDAAINAIRRAIKEF----ADIKLVSYHVDAITG--GTDALV 451
Query: 480 RVLVQTSDGKKTWGTVGASTNIIEASLNAIMESM 513
V+VQ K GA T+II AS+ A +E +
Sbjct: 452 DVVVQLKKDNKIVTARGARTDIIMASVEAFIEGI 485
>pir||D69064 isopropylmalate synthase - Methanobacterium thermoautotrophicum
(strain Delta H) >gi|2622597|gb|AAB85956.1| (AE000909)
isopropylmalate synthase [Methanobacterium
thermoautotrophicum]
Length = 505
Score = 268 bits (678), Expect = 1e-70
Identities = 168/514 (32%), Positives = 283/514 (54%), Gaps = 26/514 (5%)
Query: 1 MLMKRRVELYDTTLRDGSQMEGISFSLEDKLKITEKLDEFGIHYIEGGWPGSNPKDIQYF 60
M + V ++DTTLRDG Q G++ ++E+K I KLD G+ IE G+P ++P ++
Sbjct: 10 MNLPENVRIFDTTLRDGEQTPGVALTVEEKTGIARKLDALGVDTIEAGFPAASPGEMNSI 69
Query: 61 KAVRDLPLENAKIAAFGSTRRPRLRPEEDPNLNALVESEAPIATIFGKSWDLHVTEALRT 120
+ + +L LE A I LR + D ++ V+ I T G S LH L+
Sbjct: 70 RRIVELGLE-ANICGLARV----LREDIDAAIDCGVDY---IHTFIGTS-PLHREYKLKM 120
Query: 121 TLENNIQMIIDSIEYLRDHGMVVFYDAEHFFDGYRENPEYAMKTIKAAEEAGAERIVLAD 180
+ + I + +EY +HG+ V + AE D R +Y ++ +AAE+AGAE I + D
Sbjct: 121 SPDEIIDRAVFGVEYAAEHGLKVEFSAE---DATRTEFDYLVEVYRAAEDAGAEIINVPD 177
Query: 181 TNGGSLPSFIKEVVEKVKEEVKTPLGIHAHNDSELAVANSLIAFEAGVVQIQGTINGYGE 240
T G +P + +V ++KEE++ P+ +H HND LAVANSL A EAG Q+ T+NG GE
Sbjct: 178 TVGVMIPRAMNHLVSRLKEELRVPISVHCHNDFGLAVANSLAAVEAGASQVHATVNGLGE 237
Query: 241 RCGNANLISIIPALELKYGVEVVGKERLRKLKELAHFVAELANMEIPRNQPYVGDSAFAH 300
R GNA L ++ AL +Y + V R +L ++ FV+++ + +P N+ VG++AFAH
Sbjct: 238 RAGNAALEEVVMALITRYDLPV--DIRTVELVNISEFVSKITGVRMPPNKAIVGENAFAH 295
Query: 301 KGGVHVSAVLKNPRTYEHIDPELVGNRRKVVVSELSGRSNLIYKAKELGIELEERDIKRI 360
+ G+HV VL+ TYE I PE+VG++R++V+ + +G + L K +E GIE++E +
Sbjct: 296 EAGIHVHGVLEKAETYEPITPEMVGHKRRIVLGKHTGANALRSKLQEYGIEMKEEQFCTL 355
Query: 361 VEEIKKLEFEGYHFEAAEASLELLIERLRGR-YKPFFELERARVITEIFQGQPPISEANV 419
E++K+L +G +A L + + G+ + +LE V+T G+ + A V
Sbjct: 356 YEQVKRLGDKGKRI--TDADLRAMAVTILGKASREIVKLEGIAVMT----GESVMPTATV 409
Query: 420 VVRVNSRRVHTTAEGNGPVNALDLALRKALTKFYPELKEIKLVDYKVRVLGSEKGTAAKV 479
+R+ T+ G GPV+A A++ ++ E +I+L +Y + + A+V
Sbjct: 410 KLRIGDEVKTTSMTGVGPVDAAINAIQSLVS----ETADIELDEYNIEAITGGTNALAEV 465
Query: 480 RVLVQTSDGKKTWGTVGASTNIIEASLNAIMESM 513
V++ +G K G +I+ AS+ A+++++
Sbjct: 466 FVVMSDGEGNKATGR-STREDIVMASVEAVLDAI 498
>sp|Q58595|YB95_METJA PUTATIVE 2-ISOPROPYLMALATE/HOMOCITRATE SYNTHASE MJ1195
>gi|2127714|pir||B64449 2-isopropylmalate synthase (EC
4.1.3.12) - Methanococcus jannaschii
>gi|1591824|gb|AAB99199.1| (U67561) 2-isopropylmalate
synthase (leuA) [Methanococcus jannaschii]
Length = 518
Score = 258 bits (653), Expect = 9e-68
Identities = 178/525 (33%), Positives = 288/525 (53%), Gaps = 36/525 (6%)
Query: 6 RVELYDTTLRDGSQMEGISFSLEDKLKITEKLDEFGIHYIEGGWPGSNPKDIQYFKAVRD 65
RV ++DTTLRDG Q G+S + E+K+ I KLD+ G+ IE G+P S+ + + K +
Sbjct: 23 RVYIFDTTLRDGEQTPGVSLTPEEKIDIAIKLDDLGVDVIEAGFPVSSLGEQEAIKKICS 82
Query: 66 LPLENAKIAAFGSTRRPRLRPEEDPNLNALVESEAPIATIFGKSWDLHVTEALRTTLENN 125
L L+ A+I ++ + D ++ V+ I T S LH L+ + E
Sbjct: 83 LNLD-AEICGLARA----VKKDIDVAIDCGVDR---IHTFIATS-PLHRKYKLKKSKEEI 133
Query: 126 IQMIIDSIEYLRDHGMVVFYDAEHFFDGYRENPEYAMKTIKAAEEAGAERIVLADTNGGS 185
I + +D+IEY+++HG+ V + AE D R +Y ++ K A +AGA+ I + DT G
Sbjct: 134 IDIAVDAIEYIKEHGIRVEFSAE---DATRTEIDYLIEVYKKAVDAGADIINVPDTVGVM 190
Query: 186 LPSFIKEVVEKVKEEVKTPLGIHAHNDSELAVANSLIAFEAGVVQIQGTINGYGERCGNA 245
+P + ++ ++K+E+K P+ +H HND LAVANSL A EAG Q+ TING GER GNA
Sbjct: 191 IPRAMYYLINELKKEIKVPISVHCHNDFGLAVANSLAAVEAGAEQVHCTINGLGERGGNA 250
Query: 246 NLISIIPALELKYGVEVVGKERLRKLKELAHFVAELANMEIPRNQPYVGDSAFAHKGGVH 305
L ++ +L YGV+ + +KL E++ V++ +++ N+ VG++AFAH+ G+H
Sbjct: 251 ALEEVVMSLMSIYGVKT--NIKTQKLYEISQLVSKYTEIKVQPNKAIVGENAFAHESGIH 308
Query: 306 VSAVLKNPRTYEHIDPELVGNRRKVVVSELSGRSNLIYKAKELGIE----LEERDIKRIV 361
VL + TYE I PELVG +RK+++ + +G + K KELGIE + + IV
Sbjct: 309 AHGVLAHALTYEPIPPELVGQKRKIILGKHTGTHAIEAKLKELGIEVGKDINKDQFDEIV 368
Query: 362 EEIKKLEFEGYHFEAAEASLELLIERLRGRYKP---FFELERARVITEIFQGQPPISEAN 418
+ IK L +G + +E ++E + G+ ELE+ V+T G I A+
Sbjct: 369 KRIKALGDKGK--RVTDRDVEAIVEDVVGKLAKKDRVVELEQIAVMT----GNRVIPTAS 422
Query: 419 VVVRVNSRRVHTTAEGNGPVNALDLALRKALTKFYPELKEIKLVDYKVRVLGSEKGTAAK 478
V +++ ++A G GPV+A A++KA+ ++IKL +Y + + GT A
Sbjct: 423 VALKIEEEIKKSSAIGVGPVDAAVKAIQKAIG------EKIKLKEYHINAITG--GTDAL 474
Query: 479 VRVLVQTSDGKKTWGTVGASTNIIEASLNAIMESMEYWLMKEREK 523
V+V + T AS +I+ AS+ A+++ + L K REK
Sbjct: 475 AEVIVTLEGYGREITTKAASEDIVRASVEAVIDGINKILAK-REK 518
>gi|11497835 2-isopropylmalate synthase (leuA-2) [Archaeoglobus fulgidus]
>gi|7447060|pir||C69277 2-isopropylmalate synthase
(leuA-2) homolog - Archaeoglobus fulgidus
>gi|2650424|gb|AAB91014.1| (AE001091) 2-isopropylmalate
synthase (leuA-2) [Archaeoglobus fulgidus]
Length = 503
Score = 241 bits (609), Expect = 1e-62
Identities = 153/521 (29%), Positives = 278/521 (52%), Gaps = 30/521 (5%)
Query: 7 VELYDTTLRDGSQMEGISFSLEDKLKITEKLDEFGIHYIEGGWPGSNPKDIQYFKAVRDL 66
+ ++DTTLRDG QM G+S LE K++I ++LD+ G+ IE G+P + + + K + L
Sbjct: 8 IRVFDTTLRDGEQMPGVSLPLEYKIRIAKQLDKLGVDVIEAGFPSATKGEFESVKEISSL 67
Query: 67 PLENAKIAAFGSTRRPRLRPEEDPNLNALVESEAPIATIFGKSWDLHVTEALRTTLENNI 126
L NA+I R+ E+ ++A + + + IF + + + ++ + E I
Sbjct: 68 SL-NAEICGLA-----RIVKED---IDAAINANVDMVHIFVPTSRIQIEHTVKMSKEEII 118
Query: 127 QMIIDSIEYLRDHGMVVFYDAEHFFDGYRENPEYAMKTIKAAEEAGAERIVLADTNGGSL 186
+ ++ +EY++ HG+ + A D R EY + KA E A + + + DT G +
Sbjct: 119 EKSVECVEYIKSHGVKCMFSA---MDATRTEVEYLKQIFKAVENAKVDIVNVPDTVGVAT 175
Query: 187 PSFIKEVVEKVKEEVKTPLGIHAHNDSELAVANSLIAFEAGVVQIQGTINGYGERCGNAN 246
P E++++++E +K P+ +H HND LAVAN+ A AG ++Q T+NG GER GNA+
Sbjct: 176 PFKFYELIKQLREHLKVPIDVHCHNDFGLAVANTYAAVMAGANEVQVTVNGIGERAGNAD 235
Query: 247 LISIIPALELKYGVEVVGKERLRKLKELAHFVAELANMEIPRNQPYVGDSAFAHKGGVHV 306
L ++ L G++ + L E + V L +++P N P VG++AF+H+ G+H
Sbjct: 236 LAQVVMILHAIEGIKT--NIKTEHLFETSKLVERLTGVKMPPNHPIVGENAFSHESGIHA 293
Query: 307 SAVLKNPRTYEH--IDPELVGNRRKVVVSELSGRSNLIYKAKELGIELEERDIKRIVEEI 364
VLK T+E + PE+VG++R++V+ + +GR + +E G L++ + +I E++
Sbjct: 294 HGVLKEYSTFEPGVVTPEMVGHKRRIVIGKHAGRYQIKKILEEAGYHLDDEKLNQIFEKV 353
Query: 365 KKLEFEGYHFEAAEASLELLIERLRGRYKPFFELERARVITE--IFQGQPPISEANVVVR 422
K++ +G + L + E + G K E+A ++ E + G A +
Sbjct: 354 KEMGDKGK--RVTDLDLFAIAEVVIGELK---REEKAILVDEVTVLTGNKITPTAVLNAE 408
Query: 423 VNSRRVHTTAEGNGPVNALDLALRKALTKFYPELKEIKLVDYKVRVLGSEKGTAAKVRVL 482
V R T+A G GPV+ A KA+T E I++ ++++ + A+V V
Sbjct: 409 VFGHRKVTSAIGVGPVD----ASLKAVTSLVGE--SIRITEFRMDAITGGSDALAEVYVT 462
Query: 483 VQTSDGKKTWGTVGASTNIIEASLNAIMESMEYWLMKEREK 523
V+ +G ++ + GA+ +I+ AS++A++ ++ Y L +R K
Sbjct: 463 VEDDEG-HSFTSRGAAQDIVMASIDAVINAVNYLLRMKRRK 502
>pir||H69084 2-isopropylmalate synthase - Methanobacterium thermoautotrophicum
(strain Delta H) >gi|2622757|gb|AAB86103.1| (AE000922)
2-isopropylmalate synthase [Methanobacterium
thermoautotrophicum]
Length = 391
Score = 235 bits (593), Expect = 1e-60
Identities = 128/366 (34%), Positives = 214/366 (57%), Gaps = 14/366 (3%)
Query: 6 RVELYDTTLRDGSQMEGISFSLEDKLKITEKLDEFGIHYIEGGWPGSNPKDIQYFKAVRD 65
R+ +YDTTLRDG Q G+ E+KL+I KLDE GIH IE G+P + ++ K++ +
Sbjct: 19 RITIYDTTLRDGEQTPGVCLGTEEKLEIARKLDELGIHQIESGFPVVSEQERVSVKSIAN 78
Query: 66 LPLENAKIAAFGSTRRPRLRPEEDPNLNALVESEAPIATIFGKSWDLHVTEALRTTLENN 125
L NA+I A T++ +++A ++ + F + DLH+ L+ T E
Sbjct: 79 EGL-NAEILALCRTKKD--------DIDAAIDCDVDGVITFMATSDLHLKHKLKLTREEA 129
Query: 126 IQMIIDSIEYLRDHGMVVFYDAEHFFDGYRENPEYAMKTIKAAEEAGAERIVLADTNGGS 185
+ + ++SIEY +DHG+ + + AE D R + ++ + + AE GA+R+ +ADT G
Sbjct: 130 LNVCMNSIEYAKDHGLFLAFSAE---DATRTDLDFLKQIYRKAENYGADRVHIADTVGAI 186
Query: 186 LPSFIKEVVEKVKEEVKTPLGIHAHNDSELAVANSLIAFEAGVVQIQGTINGYGERCGNA 245
P + +V +++ ++K + +H HND +A++NS+ AG + T+NG GER GN
Sbjct: 187 SPQGMDYLVRELRRDIKVDIALHCHNDFGMALSNSIAGLLAGGTAVSTTVNGIGERAGNT 246
Query: 246 NLISIIPALELKYGVEVVGKERLRKLKELAHFVAELANMEIPRNQPYVGDSAFAHKGGVH 305
+L +I AL + Y V++ + L EL+ V + M++P N+P VG + F H+ G+H
Sbjct: 247 SLEELIMALRIIYEVDL--GFNIGVLYELSRLVEKHTRMKVPENKPIVGRNVFRHESGIH 304
Query: 306 VSAVLKNPRTYEHIDPELVGNRRKVVVSELSGRSNLIYKAKELGIELEERDIKRIVEEIK 365
V AV++ P TYE PE++G++RK+V+ + SG + K +E GI++ ++ RIVEE+K
Sbjct: 305 VDAVIEEPLTYEPFLPEMIGHQRKIVLGKHSGCRAVKAKLEEYGIDVTRDELCRIVEEVK 364
Query: 366 KLEFEG 371
K +G
Sbjct: 365 KNREKG 370
>sp|Q57926|Y503_METJA PUTATIVE 2-ISOPROPYLMALATE/HOMOCITRATE SYNTHASE MJ0503
>gi|2127715|pir||G64362 2-isopropylmalate synthase (EC
4.1.3.12) - Methanococcus jannaschii
>gi|1591206|gb|AAB98494.1| (U67500) 2-isopropylmalate
synthase (leuA) [Methanococcus jannaschii]
Length = 406
Score = 227 bits (572), Expect = 3e-58
Identities = 137/389 (35%), Positives = 218/389 (55%), Gaps = 17/389 (4%)
Query: 7 VELYDTTLRDGSQMEGISFSLEDKLKITEKLDEFGIHYIEGGWPGSNPKDIQYFKAVRDL 66
+ +YDTTLRDG Q G+ F+ E KL+I KLDE G+ IE G+P + ++ K + +
Sbjct: 32 IYIYDTTLRDGEQTPGVCFTKEQKLEIARKLDELGLKQIEAGFPIVSEREADIVKTIANE 91
Query: 67 PLENAKIAAFGSTRRPRLRPEEDPNLNALVESEAPIATIFGKSWDLHVTEALRT-TLENN 125
L NA I A + +++ +E + F + LH+ +L+
Sbjct: 92 GL-NADILALCRALKK--------DIDKAIECDVDGIITFIATSPLHLKYKFNNKSLDEI 142
Query: 126 IQMIIDSIEYLRDHGMVVFYDAEHFFDGYRENPEYAMKTIKAAEEAGAERIVLADTNGGS 185
++M ++++EY ++HG+ V + AE D R E +K KAAEEAGA+R+ +ADT G +
Sbjct: 143 LEMGVEAVEYAKEHGLFVAFSAE---DATRTPIEDLIKVHKAAEEAGADRVHIADTTGCA 199
Query: 186 LPSFIKEVVEKVKEEVKTP-LGIHAHNDSELAVANSLIAFEAGVVQIQGTINGYGERCGN 244
P ++ + + +KE +K +G+H HND AV NS+ G + T+NG GER GN
Sbjct: 200 TPQSMEFICKTLKENLKKAHIGVHCHNDFGFAVINSIYGLIGGAKAVSTTVNGIGERAGN 259
Query: 245 ANLISIIPALELKYGVEVVGKERLRKLKELAHFVAELANMEIPRNQPYVGDSAFAHKGGV 304
A L +I AL + Y V++ L L EL V E + +++P+N+P VG+ FAH+ G+
Sbjct: 260 AALEELIMALTVLYDVDL--GLNLEVLPELCRMVEEYSGIKMPKNKPIVGELVFAHESGI 317
Query: 305 HVSAVLKNPRTYEHIDPELVGNRRKVVVSELSGRSNLIYKAKELGIELEERDIKRIVEEI 364
HV AV++NP TYE PE +G +R +++ + SG + YK K +GI+ + + IV+++
Sbjct: 318 HVDAVIENPLTYEPFLPEKIGLKRNILLGKHSGCRAVAYKLKLMGIDYDREMLCEIVKKV 377
Query: 365 KKLEFEGYHFEAAEASLELLIERLRGRYK 393
K++ EG F E E++ E LR R K
Sbjct: 378 KEIREEG-KFITDEVFKEIVEEVLRKRNK 405
>pir||F69196 2-isopropylmalate synthase - Methanobacterium thermoautotrophicum
(strain Delta H) >gi|2621811|gb|AAB85228.1| (AE000851)
2-isopropylmalate synthase [Methanobacterium
thermoautotrophicum]
Length = 496
Score = 223 bits (562), Expect = 4e-57
Identities = 159/519 (30%), Positives = 253/519 (48%), Gaps = 28/519 (5%)
Query: 6 RVELYDTTLRDGSQMEGISFSLEDKLKITEKLDEFGIHYIEGGWPGSNPKDIQYFKAVRD 65
+V + DTTLRDG Q G+S + E+KL+I K+D G IE G ++ + + + +
Sbjct: 2 QVRVLDTTLRDGEQTPGVSLTPEEKLRIALKIDALGADIIEAGSAITSEGEREGIRKITS 61
Query: 66 LPLENAKIAAFGSTRRPRLRPEEDPNLNALVESEAPIATIFGKSWDLHVTEALRTTLENN 125
L A+I +F R +++A + + + + DLH+ LR T E
Sbjct: 62 EGLR-AEICSFARAVRE--------DIDAAISCDVDSVHLVVPTSDLHLEHKLRKTREEV 112
Query: 126 IQMIIDSIEYLRDHGMVVFYDAEHFFDGYRENPEYAMKTIKAAEEAGAERIVLADTNGGS 185
++ +D EY DHG++V AE D R + ++ + EAGAERI DT G
Sbjct: 113 LEQAVDCTEYAVDHGILVELSAE---DSTRSDMDFLRTIFREGIEAGAERICACDTVGIL 169
Query: 186 LPSFIKEVVEKVKEEVKTPLGIHAHNDSELAVANSLIAFEAGVVQIQGTINGYGERCGNA 245
P E + E + PL +H HND LAVANSL AG ++ TING GER GNA
Sbjct: 170 TPERSYEFYRGLSE-LGAPLSVHCHNDFGLAVANSLAGLRAGASEVHATINGIGERAGNA 228
Query: 246 NLISIIPALELKYGVEVVGKERLRKLKELAHFVAELANMEIPRNQPYVGDSAFAHKGGVH 305
L ++ AL+ Y V+ + L E + VA + + + N+ VG++AFAH+ G+H
Sbjct: 229 ALEEVVVALKSLYDVDT--SINIEMLYETSRMVARMTGVYLQPNKAIVGENAFAHESGIH 286
Query: 306 VSAVLKNPRTYEHIDPELVGNRRKVVVSELSGRSNLIYKAKELGIELEERDIKRIVEEIK 365
VLK TYE I PE+VG+ R V+ + G L + ELG+++ + + I +K
Sbjct: 287 ADGVLKKAETYEPITPEMVGHGRGFVMGKHIGTHALRKRLDELGMKVADDKLMEIFRRVK 346
Query: 366 KLEFEGYHFEAAEASLELLIERLRGRYK-PFFELERARVITEIFQGQPPISEANVVVRVN 424
L G + L+ + E + G + +L+ +++ G A+V +RV+
Sbjct: 347 TLGDMGKC--VTDVDLQAIAEDVLGVMEDKVVDLQEVTIVS----GNRVTPTASVKLRVD 400
Query: 425 SRRVHTTAEGNGPVNALDLALRKALTKFYPELKEIKLVDYKVRVLGSEKGTAAKVRVLVQ 484
R V G GPV+A +A++K+L F +I L +Y V + GT A + V+++
Sbjct: 401 DREVLEAGTGVGPVDAAIVAIKKSLEDF----ADITLEEYHVDAITG--GTDALIDVVIK 454
Query: 485 TSDGKKTWGTVGASTNIIEASLNAIMESMEYWLMKEREK 523
G + +II AS+ A + + L E+ +
Sbjct: 455 LRHGDRIISARSTQPDIIMASVEAFLSGVNRLLANEKSE 493
>dbj|BAB06777.1| (AP001517) 2-isopropylmalate synthase [Bacillus halodurans]
Length = 515
Score = 217 bits (546), Expect = 3e-55
Identities = 159/529 (30%), Positives = 269/529 (50%), Gaps = 38/529 (7%)
Query: 5 RRVELYDTTLRDGSQMEGISFSLEDKLKITEKLDEFGIHYIEGGWPGSNPKDIQYFKAVR 64
R++ ++DTTLRDG Q G++ + E+K++I ++L+ G+ IE G+P S+ D Q KA+
Sbjct: 2 RKISVFDTTLRDGEQSAGVNLNFEEKMEIAKQLERLGVDIIEAGFPASSQGDFQSVKAIA 61
Query: 65 DLPLENAKIAAFGSTRRPRLRPEEDPNLNALVESEAPIATIFGKSWDLHVTEALRTTLEN 124
+ ++ + + + ++ + D AL +E P +F + +H+ LR T E
Sbjct: 62 ET-VKGSSVTGLARS----VQKDIDAAWEALKSAEEPRIHLFIATSPIHMEHKLRMTPEQ 116
Query: 125 NIQMIIDSIEYLRDHGMVVFYDAEHFFDGYRENPEYAMKTIKAAEEAGAERIVLADTNGG 184
I+ ++S++Y V + AE D R + + + I+A +AGA I L DT G
Sbjct: 117 VIEKAVESVKYAASRFKHVQWSAE---DASRSDFPFLAQIIEAVIQAGATVINLPDTVGY 173
Query: 185 SLPSFIKEVVEKVKEEV----KTPLGIHAHNDSELAVANSLIAFEAGVVQIQGTINGYGE 240
+ P IK + + +K+ V K L H H+D +AVANSL A + G Q++ TING GE
Sbjct: 174 TTPQEIKRMFQYMKQNVPSIDKVSLSTHNHDDLGMAVANSLAAIQGGADQVECTINGIGE 233
Query: 241 RCGNANLISIIPALEL-KYGVEVVGKERLRKLKELAHFVAELANMEIPRNQPYVGDSAFA 299
R GNA+L I AL + K E L+++K + V++L M +P N+ VG +AFA
Sbjct: 234 RAGNASLEEIAVALNIRKDHYETETGLILKEIKRTSSLVSKLTGMVVPNNKAVVGANAFA 293
Query: 300 HKGGVHVSAVLKNPRTYEHIDPELVG-NRRKVVVSELSGRSNLIYKAKELGIELEERDIK 358
H+ G+H VLKN +TYE I PE+VG + +V+ + SGR K +ELG + +
Sbjct: 294 HESGIHQDGVLKNKQTYEIITPEMVGVSSNSMVLGKHSGRHAFKTKVQELGFTGTDEQLN 353
Query: 359 RIVEEIKKLEFEGYHFEAAEASL-ELLIERLRGRYKPFFELERARVITEIFQGQPPISEA 417
I + K L + E E L L+ E+ G +EL+ ++ G + A
Sbjct: 354 NIFKAFKDLADK--KKEITEDDLFALMTEQTVGGETNHYELQ----TLQVNYGSNLTNTA 407
Query: 418 NVVVRVNSRRV-HTTAEGNGPVNALDLALRKALTKFYPELKEIKLVDYKVRVLGSEKGTA 476
+ +++ S V A G+G V A+ L + L +KL+DY+++ + +
Sbjct: 408 TITMKLPSGEVAEEAATGSGSVEAIYNTLERLLD------APVKLLDYRIQSITGGRDAL 461
Query: 477 AKVRVLVQ----TSDGKKTWGTVGASTNIIEASLNAIMESMEYWLMKER 521
A V V + S G+ G + +++EAS A + ++ + +++
Sbjct: 462 ADVYVQMDYQGVVSSGR------GTAHDVLEASAKAYLNAVNRTINRKK 504
>gb|AAK41252.1| 2-isopropylmalate synthase (leuA-2) [Sulfolobus solfataricus]
Length = 461
Score = 209 bits (526), Expect = 7e-53
Identities = 125/361 (34%), Positives = 202/361 (55%), Gaps = 12/361 (3%)
Query: 6 RVELYDTTLRDGSQMEGISFSLEDKLKITEKLDEFGIHYIEGGWPGSNPKDIQYFKAVRD 65
+V + D+TLR+G Q G+ F+++ +++I + L + G+ IE G P +P + K +
Sbjct: 3 KVGILDSTLREGEQTPGVIFTVDQRVEIAKALSDLGVSMIEAGHPAVSPDIYEGIKRIVK 62
Query: 66 LPLENAKIAAFGSTRRPRLRPEEDPNLNALVESEAPIATIFGKSWDLHVTEALRTTLENN 125
L E + R R D + A +E + IA +G S D+H+ + T E
Sbjct: 63 LKKEGIITSEIVGHSRAVKR---DIEIAAELEVDR-IAIFYGVS-DIHLKAKHKATREEA 117
Query: 126 IQMIIDSIEYLRDHGMVVFYDAEHFFDGYRENPEYAMKTIKAAEEAGAERIVLADTNGGS 185
+++I ++I Y R HG+ V + AE DG R + ++ + + A +AGA+R+ +ADT G
Sbjct: 118 LRVIAETISYARSHGVKVRFTAE---DGSRTDFDFLVTVSRTARDAGADRVSIADTVGIL 174
Query: 186 LPSFIKEVVEKVKEEVKT-PLGIHAHNDSELAVANSLIAFEAGVVQIQGTINGYGERCGN 244
PS KE+ + EV IHAHND LAVAN+L A E G + T+NG GER G
Sbjct: 175 YPSKTKELFSALIREVPNLEYDIHAHNDLGLAVANALAAVEGGATIVHATVNGLGERVGI 234
Query: 245 ANLISIIPALELKYGVEVVGKERLRKLKELAHFVAELANMEIPRNQPYVGDSAFAHKGGV 304
L I+ A++ +G+EVV +L KL+ ++ + + + + +P N P GD AF HK GV
Sbjct: 235 VPLQQIVAAIKYHFGIEVV---KLDKLQYVSSLIEKYSGIPMPPNYPITGDYAFLHKAGV 291
Query: 305 HVSAVLKNPRTYEHIDPELVGNRRKVVVSELSGRSNLIYKAKELGIELEERDIKRIVEEI 364
HV+ VL +PRTYE + PE G R + + +G+ L K ++LG+++ E ++ +I+ +I
Sbjct: 292 HVAGVLSDPRTYEFMPPETFGRTRDYTIDKYTGKHALRDKYEKLGVKISEAEMDQILAKI 351
Query: 365 K 365
K
Sbjct: 352 K 352
>sp|P94565|LEU1_BACSU 2-ISOPROPYLMALATE SYNTHASE (ALPHA-ISOPROPYLMALATE SYNTHASE)
(ALPHA-IPM SYNTHETASE) >gi|7447054|pir||H69649
2-isopropylmalate synthase (EC 4.1.3.12) - Bacillus
subtilis >gi|1770069|emb|CAA99531.1| (Z75208)
2-isopropylmalate synthase [Bacillus subtilis]
>gi|2635293|emb|CAB14788.1| (Z99118) 2-isopropylmalate
synthase [Bacillus subtilis]
Length = 518
Score = 207 bits (521), Expect = 3e-52
Identities = 157/523 (30%), Positives = 260/523 (49%), Gaps = 31/523 (5%)
Query: 5 RRVELYDTTLRDGSQMEGISFSLEDKLKITEKLDEFGIHYIEGGWPGSNPKDIQYFKAVR 64
R++ +DTTLRDG Q G++ + ++KL I ++L+ G IE G+P S+ D F AV+
Sbjct: 2 RKINFFDTTLRDGEQSPGVNLNTQEKLAIAKQLERLGADIIEAGFPASSRGD---FLAVQ 58
Query: 65 DLPLENAKIAAFGSTRRPRLRPEEDPNLNALVESEAPIATIFGKSWDLHVTEALRTTLEN 124
++ + G R ++ + D AL + P +F + D+H+ L+ T E
Sbjct: 59 EIARTIKNCSVTGLARC--VKGDIDAAWEALKDGAQPRIHVFIATSDIHLKHKLKMTREQ 116
Query: 125 NIQMIIDSIEYLRDHGMVVFYDAEHFFDGYRENPEYAMKTIKAAEEAGAERIVLADTNGG 184
I+ + ++Y ++ +V + AE D R + + ++ +AGA I L DT G
Sbjct: 117 VIERAVGMVKYAKERFPIVQWSAE---DACRTELPFLAEIVEKVIDAGASVINLPDTVGY 173
Query: 185 SLPSFIKEVVEKVKEEV----KTPLGIHAHNDSELAVANSLIAFEAGVVQIQGTINGYGE 240
P+ + + +KE V K L H H+D +AVANSL A E G QI+ +NG GE
Sbjct: 174 LAPAEYGNIFKYMKENVPNIHKAKLSAHCHDDLGMAVANSLAAIENGADQIECAVNGIGE 233
Query: 241 RCGNANLISIIPALELK---YGVEVVGKERLRKLKELAHFVAELANMEIPRNQPYVGDSA 297
R GNA L I AL + Y VE L ++K + V++L M +PRN+ VGD+A
Sbjct: 234 RAGNAALEEIAVALHTRKDFYQVET--GITLNEIKRTSDLVSKLTGMAVPRNKAVVGDNA 291
Query: 298 FAHKGGVHVSAVLKNPRTYEHIDPELVG-NRRKVVVSELSGRSNLIYKAKELGIELEERD 356
FAH+ G+H LK TYE I PELVG +V+ + SGR + LG + + +
Sbjct: 292 FAHESGIHQDGFLKEKSTYEIISPELVGVTADALVLGKHSGRHAFKDRLTALGFQFDSEE 351
Query: 357 IKRIVEEIKKLEFEGYHFEAAEASLELLIERLRGRYKPFFELERARVITEIFQGQPPISE 416
I + K+L + + +L E++ R K +E +V Q P +
Sbjct: 352 INKFFTMFKELTEKKKEITDEDLVSLILEEKVTDR-KIGYEFLSLQV--HYGTSQVPTAT 408
Query: 417 ANVVVRVNSRRVHTTAEGNGPVNALDLALRKALTKFYPELKEIKLVDYKVRVLGSEKGTA 476
++ + N++ + A G G V A+ L + + K+++L+DY R+ + KG
Sbjct: 409 LSLKNQENAQLIQEAATGAGSVEAIYNTLERCID------KDVELLDY--RIQSNRKGED 460
Query: 477 AKVRVLVQT-SDGKKTWGTVGASTNIIEASLNAIMESMEYWLM 518
A +V V+ +GK++ G G + +++EAS A + ++ L+
Sbjct: 461 AFAQVYVRVLVNGKESAGR-GIAQDVLEASAKAYLNAVNRQLV 502
>pir||A75045 2-isopropylmalate synthase (leua-1) PAB0890 - Pyrococcus abyssi
(strain Orsay) >gi|5458767|emb|CAB50254.1| (AJ248287)
2-isopropylmalate synthase (leuA-1) [Pyrococcus abyssi]
Length = 486
Score = 204 bits (514), Expect = 2e-51
Identities = 159/510 (31%), Positives = 266/510 (51%), Gaps = 35/510 (6%)
Query: 5 RRVELYDTTLRDGSQMEGISFSLEDKLKITEKLDEFGIHYIEGGWPGSNPKDIQYFKAVR 64
R+V ++DTTLRDG Q G+S ++E+K++I ++L + + IE G+P ++ + FKAV+
Sbjct: 2 RKVYIFDTTLRDGEQTPGVSLTVEEKVEIAKQLAKLNVDVIEAGFPIASEGE---FKAVK 58
Query: 65 DLP--LENAKIAAFGSTRRPRLRPEEDPNLNALVESEAPIATIFGKSWDLHVTEALRTTL 122
+ +E+ IAA + + D AL +E F + +H+ LR
Sbjct: 59 KIATEVEDPTIAALARA----VEKDIDRAGEALRNAEKNRIHTFIATSPIHMKYKLRKEP 114
Query: 123 ENNIQMIIDSIEYLRDHGMVVFYDAEHFFDGYRENPEYAMKTIKAAEEAGAERIVLADTN 182
E ++ + ++E+ + V + AE D R + ++ ++ +A +AGA I + DT
Sbjct: 115 EEVKKLAVKAVEHATKYTEDVEFSAE---DATRSDWDFLVEVYEAVIDAGATVINVPDTV 171
Query: 183 GGSLPSFIKEVVEKVKEEVKTPLGI----HAHNDSELAVANSLIAFEAGVVQIQGTINGY 238
G + P E+V ++ + G+ H H+D LAVANSL A AG Q++ T+NG
Sbjct: 172 GYATPEEFYELVRYLRRNISNIKGVQISVHCHDDLGLAVANSLSAIRAGADQVEVTVNGI 231
Query: 239 GERCGNANLISIIPALELKYGVEVVGKE-RLRKLKELAHFVAELANMEIPRNQPYVGDSA 297
GER GNA L +I AL+++ V + L+++ + V+ L +E+P N+ VG +A
Sbjct: 232 GERAGNAALEEVIVALDVRRDFYKVKTDVNLKEIARTSKLVSHLTGIEVPPNKAIVGGNA 291
Query: 298 FAHKGGVHVSAVLKNPRTYEHIDPELVG-NRRKVVVSELSGRSNLIYKAKELGIELEERD 356
FAH+ G+H VLK TYE IDP+ +G + K+V+ + SGR K +ELG L E
Sbjct: 292 FAHESGIHQDGVLKERTTYEIIDPKKLGFSGSKIVLGKHSGRHAFRKKLEELGYSLTEEH 351
Query: 357 IKRIVEEIKKLEFEGYHFEAAEASLELLIERLRGRYKPFFELERARVITEIFQGQPPISE 416
++R ++ K + + +E +I+ + ++E I + G+ +S
Sbjct: 352 LERAFKKFKDIADRKRWI--TDTDIEAIIQEELTKSNGKLKVE----IIHVTSGK--VST 403
Query: 417 ANVVVRVN-SRRVHTTAEGNGPVNALDLALRKALTKFYPELKEIKLVDYKVRVLGSEKGT 475
A V + +N R+ NGP++AL A+ KAL +E KL +Y+V + S K +
Sbjct: 404 ATVRISMNGEERIEVAWFKNGPIDALFSAINKALG------EEFKLREYRVSSVTSGKDS 457
Query: 476 AAKVRVLVQTSDGKKTWGTVGASTNIIEAS 505
+V V V+ +G+ G G ST+IIEAS
Sbjct: 458 LGEVLVRVEV-NGEIFVGR-GLSTDIIEAS 485
>sp|O67862|LEU1_AQUAE 2-ISOPROPYLMALATE SYNTHASE (ALPHA-ISOPROPYLMALATE SYNTHASE)
(ALPHA-IPM SYNTHETASE) >gi|7447051|pir||B70479
2-isopropylmalate synthase (EC 4.1.3.12) - Aquifex
aeolicus >gi|2984301|gb|AAC07824.1| (AE000772)
2-isopropylmalate synthase [Aquifex aeolicus]
Length = 524
Score = 201 bits (507), Expect = 1e-50
Identities = 158/541 (29%), Positives = 268/541 (49%), Gaps = 42/541 (7%)
Query: 3 MKRRVELYDTTLRDGSQMEGISFSLEDKLKITEKLDEFGIHYIEGGWPGSNPKDIQYFKA 62
M +V ++DTTLRDG Q G S + E+KL++ +L + + IE G+ ++ D F+A
Sbjct: 5 MGEKVYIFDTTLRDGEQAPGFSMTTEEKLQMAHQLAKLNVDIIEAGFAAASKGD---FEA 61
Query: 63 VRDLPLENAKIAAFGSTRRPRLRPEEDPNLNALVESEAPIATIFGKSWDLHVTEALRTTL 122
V + E K S R L + + AL +E F + +H+ LR T
Sbjct: 62 VNRIAKE-VKGPVICSLARA-LESDIEIAAKALEPAERKRIHTFIATSPIHMEYKLRMTP 119
Query: 123 ENNIQMIIDSIEYLRDHGMVVFYDAEHFFDGYRENPEYAMKTIKAAEEAGAERIVLADTN 182
+ ++ I ++ + R+ V + E D R E+ + I+ A + GA I + DT
Sbjct: 120 DQVLERIKKAVSFARNFTDDVEFSCE---DATRSEREFLYRAIETAIKHGATVINIPDTV 176
Query: 183 GGSLPSFIKEVVEKVKEEV----KTPLGIHAHNDSELAVANSLIAFEAGVVQIQGTINGY 238
G ++P +++E + V K L +H H+D LA ANSL A + G Q++ TING
Sbjct: 177 GYAIPEEFGQLIEDIMNNVPNIDKVILSVHCHDDLGLATANSLTAVKHGARQVECTINGI 236
Query: 239 GERCGNANLISIIPALELK--YGVEVVGKERLRKLKELAHFVAELANMEIPRNQPYVGDS 296
GER GNA L ++ AL+++ + ++ +++ + + + + + N+ VGD+
Sbjct: 237 GERAGNAALEEVVMALKVRKDFFGDLYTDVNTKEIYKTSRLLCRITGNFVQPNKAIVGDN 296
Query: 297 AFAHKGGVHVSAVLKNPRTYEHIDPELVG-NRRKVVVSELSGRSNLIYKAKELGIELEER 355
AFAH+ G+H VL + TYE ++PE VG ++V+ + SGR L + +ELG + +
Sbjct: 297 AFAHESGIHQHGVLSHRMTYEIMNPEDVGFPMSRIVLGKHSGRHALKRRLEELGFKFTKE 356
Query: 356 DIKRIVEEIKKLEFEGYHFEAAEASLELLIERLRGRYKPFFELERARVIT----EIFQGQ 411
++ RI E+ K E E + LE LI Y+ F ++E + ++ G
Sbjct: 357 ELDRIFEKFK--ELADRKKEVYDEDLEALI------YQEFMKIEDHEPVKVLHFQVQSGD 408
Query: 412 PPISEANVVVRVNSRRVHTTAEGNGPVNALDLALRKALTKFYPELKEIKLVDYKVRVLGS 471
I A V + ++ GNGPV+A A++KAL E KL+DY ++ L
Sbjct: 409 NMIPTATVKLEFKGEEREASSTGNGPVDATIKAIQKALG------IEPKLLDYSIKALTP 462
Query: 472 EKGTAAKVRVLVQTSDGKKTWGTVGASTNIIEASLNAIMESM-------EYWLMKEREKD 524
A+ RV+++ DG K G G T+II+AS+ A +++ EY + ++ ++
Sbjct: 463 NTDAQAEARVVLEL-DGVKASGR-GVDTDIIKASVKAFTDALNRAIVRKEYIIQRQEIRE 520
Query: 525 E 525
E
Sbjct: 521 E 521
>sp|Q9WZ23|LEU1_THEMA 2-ISOPROPYLMALATE SYNTHASE (ALPHA-ISOPROPYLMALATE SYNTHASE)
(ALPHA-IPM SYNTHETASE) >gi|7447055|pir||G72362
2-isopropylmalate synthase - Thermotoga maritima (strain
MSB8) >gi|4981068|gb|AAD35638.1|AE001730_6 (AE001730)
2-isopropylmalate synthase [Thermotoga maritima]
Length = 513
Score = 199 bits (500), Expect = 8e-50
Identities = 156/527 (29%), Positives = 264/527 (49%), Gaps = 40/527 (7%)
Query: 5 RRVELYDTTLRDGSQMEGISFSLEDKLKITEKLDEFGIHYIEGGWPGSNPKDIQYFKAVR 64
RR++++DTTLRDG Q G S S+E+K+++ L++ G+ IE G+P S+P F+AV+
Sbjct: 2 RRIKIFDTTLRDGEQSPGASMSIEEKVEMALMLEDLGVDLIEAGFPVSSPVQ---FEAVK 58
Query: 65 DLPLENAKIAAFGSTRRPRLRPEEDPNLNALVE--SEAPIATIFGKSWDLHVTEALRTTL 122
+ K G R + + D AL + + + +F + +H LR
Sbjct: 59 RVASAVQKPIVVGLAR--CVEKDIDAAYEALKDRPKDKRMIHVFIATSPIHRKYKLRMEK 116
Query: 123 ENNIQMIIDSIEYLRDHGMVVFYDAEHFFDGYRENPEYAMKTIKAAEEAGAERIVLADTN 182
E ++ I + Y + +V + AE D R + ++ K A EAGA I + DT
Sbjct: 117 EEILERIRRYVGYAKQFFDLVEFSAE---DASRTEVPFLIEAYKTAIEAGATTINVPDTV 173
Query: 183 GGSLPSFIKEVVEKVKEEV----KTPLGIHAHNDSELAVANSLIAFEAGVVQIQGTINGY 238
G +LP E+++ ++E V L +H HND LAVANSL A + G Q++ T+NG
Sbjct: 174 GYALPDEFGELIKTLREGVPGIENVDLSVHCHNDLGLAVANSLAAVQNGATQVEVTLNGI 233
Query: 239 GERCGNANLISIIPALEL---KYGVEVVGKERLRKLKELAHFVAELANMEIPRNQPYVGD 295
GER GN L + L++ K E K L + + + + + RN+P VG+
Sbjct: 234 GERAGNCALEEFVMILKVRKDKLPYETGIKTEL--IYPASRLLTHITGLIPSRNKPIVGE 291
Query: 296 SAFAHKGGVHVSAVLKNPRTYEHIDPELVG-NRRKVVVSELSGRSNLIYKAKELGIELEE 354
+ F H+ G+H VLK+ TYE + P +G + +V+ SG+ L K + GI+L+E
Sbjct: 292 NVFLHESGIHQDGVLKHRETYEIMKPSDIGRSSETLVLGRHSGKHALRKKLETYGIKLDE 351
Query: 355 RDIKRIVEEIKKL---EFEGYHFEAAEASLELLIERLRGRYKPFFELERARVITEIFQGQ 411
+++ E+ +L + E Y + E+L E + G YK V + G
Sbjct: 352 ETFQKVFEKFTELADRKKEVYDDDLFSIVSEVLREPING-YK--------LVHFHVHTGN 402
Query: 412 PPISEANVVVRVNSRRVHTTAEGNGPVNALDLALRKALTKFYPELKEIKLVDYKVRVLGS 471
+ A VV++V + + GNGPV+A+ A+ KAL P+L+E Y ++ +G+
Sbjct: 403 TLLPTAAVVLQVGNEKREAAEAGNGPVDAIFKAIDKAL-GIQPKLEE-----YIIQAVGT 456
Query: 472 EKGTAAKVRVLVQTSDGKKTWGTVGASTNIIEASLNAIMESMEYWLM 518
K +V++ ++ + + + G ST+I+EAS A + ++ +L+
Sbjct: 457 GKNAQGEVKLTLRIDN--ELYSGRGVSTDIVEASAIAYINAINKYLI 501
>pir||S40588 hypothetical protein - Escherichia coli >gi|216492|dbj|BAA01343.1|
(D10483) 2-Isopropylmalate synthase homolog(PIR:S08431)
[Escherichia coli]
Length = 523
Score = 196 bits (493), Expect = 5e-49
Identities = 154/531 (29%), Positives = 270/531 (50%), Gaps = 32/531 (6%)
Query: 3 MKRRVELYDTTLRDGSQMEGISFSLEDKLKITEKLDEFGIHYIEGGWPGSNPKDIQYFKA 62
M ++V ++DTTLRDG Q S S+++KL+I L+ G+ +E G+P S+P D + +
Sbjct: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60
Query: 63 VRDLPLENAKIAAFGSTRRPRLRPEEDPNLNALVESEAPIATIFGKSWDLHVTEALRTTL 122
+ ++N+++ A + + D +L +EA F + +H+ LR+TL
Sbjct: 61 IAR-QVKNSRVCALARC----VEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTL 115
Query: 123 ENNIQMIIDSIEYLRDHGMVVFYDAEHFFDGYRENPEYAMKTIKAAEEAGAERIVLADTN 182
+ I+ I ++ R++ V + E D R + ++AA AGA I + DT
Sbjct: 116 DEVIERAIYMVKRARNYTDDVEFSCE---DAGRTPIADLARVVEAAINAGATTINIPDTV 172
Query: 183 GGSLP----SFIKEVVEKVKEEVKTPLGIHAHNDSELAVANSLIAFEAGVVQIQGTINGY 238
G ++P I + E+V K + +H H+D LAV NSL A AG Q++G +NG
Sbjct: 173 GYTMPFEFAGIISGLYERVPSIGKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGI 232
Query: 239 GERCGNANLISIIPALELKYGV-EVVGKERLRKLKELAHFVAELANMEIPRNQPYVGDSA 297
GER GN +L +I A++++ + V +++ + V+++ NM IP N+ VG A
Sbjct: 233 GERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGA 292
Query: 298 FAHKGGVHVSAVLKNPRTYEHIDPELVG-NRRKVVVSELSGRSNLIYKAKELGIELEERD 356
FAH G+H VLKN YE + PE +G N+ ++ ++ SGR+ + ++ E+G + E +
Sbjct: 293 FAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYN 352
Query: 357 IKRIVEEIKKL-EFEGYHFEAAEASLELLIERLRGRYKP-FFELERARVITEIFQGQPPI 414
+ + + KL + +G F + LE L + + +P F L+ + G I
Sbjct: 353 LDNLYDAFLKLADKKGQVF---DYDLEALAFIGKQQEEPEHFRLD----YFSVQSGSNDI 405
Query: 415 SEANVVVRVNSRRVHTTAEGNGPVNALDLALRKALTKFYPELKEIKLVDYKVRVLGSEKG 474
+ A V + A GNGPV+A+ A+ + +T++ ++LV Y + G K
Sbjct: 406 ATAAVKLACGEEVKAEAANGNGPVDAVYQAINR-ITEY-----NVELVKYSLTAKGHGKD 459
Query: 475 TAAKVRVLVQTSDGKKTWGTVGASTNIIEASLNAIMESM-EYWLMKEREKD 524
+V + V +G++ G VG +T+I+E+S A++ + W E EK+
Sbjct: 460 ALGQVDI-VANYNGRRFHG-VGLATDIVESSAKAMVHVLNNIWRAAEVEKE 508
>sp|P09151|LEU1_ECOLI 2-ISOPROPYLMALATE SYNTHASE (ALPHA-ISOPROPYLMALATE SYNTHASE)
(ALPHA-IPM SYNTHETASE) >gi|7447053|pir||B64729
2-isopropylmalate synthase (EC 4.1.3.12) - Escherichia
coli >gi|1786261|gb|AAC73185.1| (AE000117)
2-isopropylmalate synthase [Escherichia coli K12]
Length = 523
Score = 196 bits (493), Expect = 5e-49
Identities = 154/531 (29%), Positives = 270/531 (50%), Gaps = 32/531 (6%)
Query: 3 MKRRVELYDTTLRDGSQMEGISFSLEDKLKITEKLDEFGIHYIEGGWPGSNPKDIQYFKA 62
M ++V ++DTTLRDG Q S S+++KL+I L+ G+ +E G+P S+P D + +
Sbjct: 1 MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60
Query: 63 VRDLPLENAKIAAFGSTRRPRLRPEEDPNLNALVESEAPIATIFGKSWDLHVTEALRTTL 122
+ ++N+++ A + + D +L +EA F + +H+ LR+TL
Sbjct: 61 IAR-QVKNSRVCALARC----VEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTL 115
Query: 123 ENNIQMIIDSIEYLRDHGMVVFYDAEHFFDGYRENPEYAMKTIKAAEEAGAERIVLADTN 182
+ I+ I ++ R++ V + E D R + ++AA AGA I + DT
Sbjct: 116 DEVIERAIYMVKRARNYTDDVEFSCE---DAGRTPIADLARVVEAAINAGATTINIPDTV 172
Query: 183 GGSLP----SFIKEVVEKVKEEVKTPLGIHAHNDSELAVANSLIAFEAGVVQIQGTINGY 238
G ++P I + E+V K + +H H+D LAV NSL A AG Q++G +NG
Sbjct: 173 GYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGI 232
Query: 239 GERCGNANLISIIPALELKYGV-EVVGKERLRKLKELAHFVAELANMEIPRNQPYVGDSA 297
GER GN +L +I A++++ + V +++ + V+++ NM IP N+ VG A
Sbjct: 233 GERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGA 292
Query: 298 FAHKGGVHVSAVLKNPRTYEHIDPELVG-NRRKVVVSELSGRSNLIYKAKELGIELEERD 356
FAH G+H VLKN YE + PE +G N+ ++ ++ SGR+ + ++ E+G + E +
Sbjct: 293 FAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYN 352
Query: 357 IKRIVEEIKKL-EFEGYHFEAAEASLELLIERLRGRYKP-FFELERARVITEIFQGQPPI 414
+ + + KL + +G F + LE L + + +P F L+ + G I
Sbjct: 353 LDNLYDAFLKLADKKGQVF---DYDLEALAFIGKQQEEPEHFRLD----YFSVQSGSNDI 405
Query: 415 SEANVVVRVNSRRVHTTAEGNGPVNALDLALRKALTKFYPELKEIKLVDYKVRVLGSEKG 474
+ A V + A GNGPV+A+ A+ + +T++ ++LV Y + G K
Sbjct: 406 ATAAVKLACGEEVKAEAANGNGPVDAVYQAINR-ITEY-----NVELVKYSLTAKGHGKD 459
Query: 475 TAAKVRVLVQTSDGKKTWGTVGASTNIIEASLNAIMESM-EYWLMKEREKD 524
+V + V +G++ G VG +T+I+E+S A++ + W E EK+
Sbjct: 460 ALGQVDI-VANYNGRRFHG-VGLATDIVESSAKAMVHVLNNIWRAAEVEKE 508
>gi|10954458 2-isopropylmalate synthase [Buchnera aphidicola]
>gi|3282740|gb|AAD12600.1| (AF041837) 2-isopropylmalate
synthase [Buchnera aphidicola]
Length = 516
Score = 196 bits (493), Expect = 5e-49
Identities = 155/539 (28%), Positives = 276/539 (50%), Gaps = 43/539 (7%)
Query: 3 MKRRVELYDTTLRDGSQMEGISFSLEDKLKITEKLDEFGIHYIEGGWPGSNPKDIQYFKA 62
M +V ++DTTLRDG Q S S+++KL+I L++ GI IE G+P S+P D FK+
Sbjct: 1 MSSKVIIFDTTLRDGEQALQASLSVKEKLQIALSLEKCGIDIIEVGFPISSPGD---FKS 57
Query: 63 VRDLP--LENAKIAAFGSTRRPRLRPEEDPNLNALVESEAPIATIFGKSWDLHVTEALRT 120
V+ + ++N++I + + D A+ S+ IF + LH+ LR
Sbjct: 58 VQTISKKIKNSRICSLARCVEKDIEVAGD----AMSSSDFFRIHIFLATSTLHMESKLRK 113
Query: 121 TLENNIQMIIDSIEYLRDHGMVVFYDAEHFFDGYRENPEYAMKTIKAAEEAGAERIVLAD 180
+ I M + S++ + V + E D R + + ++ +AG + I + D
Sbjct: 114 NFDEIIDMAVSSVKKALRYTDDVEFSCE---DASRTTMDNLCRIVEKLIKAGVKTINIPD 170
Query: 181 TNGGSLPSFIKEVVEKVKEEV----KTPLGIHAHNDSELAVANSLIAFEAGVVQIQGTIN 236
T G ++P+ + +++ + E V K+ + +H HND +AV NS+ A +AG QI+GTIN
Sbjct: 171 TVGYTIPNELSNIIKNLFERVPNIHKSIISVHCHNDLGMAVGNSISAIQAGARQIEGTIN 230
Query: 237 GYGERCGNANLISIIPALELKYGVEVVGKERLRK-LKELAHFVAELANMEIPRNQPYVGD 295
G GER GN L II A++++ + V + K + + ++++ NM IP N+ VG
Sbjct: 231 GIGERAGNTALEEIIMAIKVREDILGVSTNIVHKEIYRTSQIISQICNMPIPANKAIVGS 290
Query: 296 SAFAHKGGVHVSAVLKNPRTYEHIDPELVGNRR-KVVVSELSGRSNLIYKAKELGIELEE 354
+AFAH G+H VLKN + YE ++P +G + K+ ++ SGR+ + Y ++G + ++
Sbjct: 291 NAFAHSSGIHQDGVLKNRKNYEIMEPNTIGVKEVKLNLTSRSGRAAVKYYMDKMGYKDDD 350
Query: 355 RDIKRIVEEIKKL-EFEGYHFEAAEASLELLIERLRGR---YKPFFELERARVITEIFQG 410
DI + KL + +G F+ +L + ++ Y FF ++ I G
Sbjct: 351 YDIDELYSAFLKLADKKGQVFDYDLEALAIFSKKQENAEYFYLKFFSVQ------SISNG 404
Query: 411 QPPISEANVVVRVNSRRVHT--TAEGNGPVNALDLALRKALTKFYPELKEIKLVDYKVRV 468
+S A+V ++ ++V+T + NGPV+A AL K + +P I L +++
Sbjct: 405 ---LSTASVKLKC-GKKVYTESSTTSNGPVDATYQALNKIIN--FP----ITLQKFQLVA 454
Query: 469 LGSEKGTAAKVRVLVQTSDGKKTWGTVGASTNIIEASLNAIMESM-EYWLMKEREKDEK 526
G K +V +LV+ + + + +G +T+IIE+S A++ + W ++ K K
Sbjct: 455 KGKGKDALGQVDILVKYEN--RQFHGIGLATDIIESSAQAMINVLNNIWKSQQVNKKLK 511
>pir||B71181 probable 2-isopropylmalate synthase - Pyrococcus horikoshii
>gi|3258158|dbj|BAA30841.1| (AP000007) 361aa long
hypothetical 2-isopropylmalate synthase [Pyrococcus
horikoshii]
Length = 361
Score = 195 bits (491), Expect = 9e-49
Identities = 120/357 (33%), Positives = 194/357 (53%), Gaps = 17/357 (4%)
Query: 9 LYDTTLRDGSQMEGISFSLEDKLKITEKLDEFGIHYIEGGWPGSNPKDIQYFKAVRDLPL 68
+ D+TLR+G Q G+++S E +L+I LDE G+ +IE G P + K + L
Sbjct: 2 ILDSTLREGEQTPGVNYSPEQRLRIALALDEIGVDFIEVGHPAVSKDVFIGIKLIASQDL 61
Query: 69 ENAKIAAFGSTRRPRLRPEEDPNLNALVESEAPIATIFGKSWDLHVTEALRTTLENNIQM 128
NA + A R L +++ +++++ IF + + + R +L ++
Sbjct: 62 -NANLLAHS---RALLE-----DIDYVIQADVEWVGIFFCLSNACLRKRFRMSLSQALER 112
Query: 129 IIDSIEYLRDHGMVVFYDAEHFFDGYRENPEYAMKTIKAAEEAGAERIVLADTNGGSLPS 188
I +IEY +DHG+ V + E D R E + I+ A+E +RI +ADT GG+ P
Sbjct: 113 ISKAIEYAKDHGLKVRFTPE---DTTRTEWENLRRAIELAKELKVDRISVADTTGGTHPL 169
Query: 189 FIKEVVEKVKEEVKTPLGIHAHNDSELAVANSLIAFEAGVVQIQGTINGYGERCGNANLI 248
+V+KV P+ +H HND LA+AN+++ E G + T+NG GER G +L
Sbjct: 170 RFYTLVKKVVN-FGIPVNVHCHNDLGLALANAIMGIEGGATVVDATVNGLGERAGIVDLA 228
Query: 249 SIIPALELKYGVEVVGKERLRKLKELAHFVAELANMEIPRNQPYVGDSAFAHKGGVHVSA 308
I+ L YGV+ K RL KL E++ V+E+ + + N P VG++AF HK G+HVSA
Sbjct: 229 QIVTVLYYHYGVK---KYRLDKLYEISRMVSEITGIALQPNYPIVGENAFTHKAGLHVSA 285
Query: 309 VLKNPRTYEHIDPELVGNRRKVVVSELSGRSNLIYKAKELGIELEERDIKRIVEEIK 365
VLK+PR YE + E+ G R + V +G+ + Y ++LGI +E +K +++ +K
Sbjct: 286 VLKDPRFYEFLPAEVFGRERTIYVDRFAGKDTIRYYLQKLGIN-DEEFVKVLLKRVK 341
>sp|Q02141|LEU1_LACLA 2-ISOPROPYLMALATE SYNTHASE (ALPHA-ISOPROPYLMALATE SYNTHASE)
(ALPHA-IPM SYNTHETASE) >gi|486724|pir||S35132
2-isopropylmalate synthase (EC 4.1.3.12) - Lactococcus
lactis subsp. lactis
Length = 513
Score = 193 bits (486), Expect = 3e-48
Identities = 142/514 (27%), Positives = 245/514 (47%), Gaps = 30/514 (5%)
Query: 5 RRVELYDTTLRDGSQMEGISFSLEDKLKITEKLDEFGIHYIEGGWPGSNPKDIQYFKAVR 64
R++E +DT+LRDG Q G+SFS+ +K+ I ++L+++ I IE G+ ++P + K +
Sbjct: 2 RKIEFFDTSLRDGEQTPGVSFSISEKVTIAKQLEKWRISVIEAGFSAASPDSFEAVKQIA 61
Query: 65 DLPLENAKIAAFGSTRRPRLRPEEDPNLNALVESEAPIATIFGKSWDLHVTEALRTTLEN 124
D L + + A + + D + A+ ++ P +F + +H+ L+ + E
Sbjct: 62 D-SLNDTAVTALARC----VISDIDKAVEAVKGAKYPQIHVFIATSPIHMKYKLKISPEE 116
Query: 125 NIQMIIDSIEYLRDHGMVVFYDAEHFFDGYRENPEYAMKTIKAAEEAGAERIVLADTNGG 184
++ I + Y R+ VV + E D R + ++ ++ A +AGA I + DT G
Sbjct: 117 VLKNIDKCVRYARERVEVVEFSPE---DATRTELNFLLEAVQTAVDAGATYINIPDTVGY 173
Query: 185 SLPS----FIKEVVEKVKEEVKTPLGIHAHNDSELAVANSLIAFEAGVVQIQGTINGYGE 240
+ P K +++ K + + H H+D +AVANSL A +AG +++GT+NG GE
Sbjct: 174 TTPEEYGKIFKFLIDNTKSDREIIFSPHCHDDLGMAVANSLAAIKAGAGRVEGTVNGIGE 233
Query: 241 RCGNANLISIIPALEL-KYGVEVVGKERLRKLKELAHFVAELANMEIPRNQPYVGDSAFA 299
R GNA L I AL + K + +L + A +++ + + IP+N+ VG +AFA
Sbjct: 234 RAGNAALEEIAVALHIRKDFYQAQSPLKLSETAATAELISQFSGIAIPKNKAIVGANAFA 293
Query: 300 HKGGVHVSAVLKNPRTYEHIDPELVG-NRRKVVVSELSGRSNLIYKAKELGIELEERDIK 358
H+ G+H VLKN TYE I PELVG + + +LSGR K EL I ++ +
Sbjct: 294 HESGIHQDGVLKNAETYEIITPELVGIKHNSLPLGKLSGRHAFSEKLTELNIAYDDESLA 353
Query: 359 RIVEEIKKLEFEGYHFEAAEASLELLIERLRGRYKPFFELERARVITEIFQGQPPISEAN 418
+ E+ KKL + E +A + L + F L+ ++ Q E
Sbjct: 354 ILFEKFKKLADK--KKEITDADIHALFTGETVKNLAGFILDNVQIDGHKALVQLKNQEEE 411
Query: 419 VVVRVNSRRVHTTAEGNGPVNALDLALRKALTKFYPELKEIKLVDYKVRVLGSEKGTAAK 478
+ V + EG+G V+A+ A+ K ++KL+ Y V + A
Sbjct: 412 IYV--------SQGEGSGSVDAIFKAIDKVFN------HQLKLISYSVDAVTDGIDAQAT 457
Query: 479 VRVLVQTSDGKKTWGTVGASTNIIEASLNAIMES 512
V V+ + G ++++ S A M +
Sbjct: 458 TLVSVENLSTGTIFNAKGVDYDVLKGSAIAYMNA 491
>gb|AAB81913.1| (U92974) LeuA [Lactococcus lactis]
Length = 565
Score = 193 bits (486), Expect = 3e-48
Identities = 142/514 (27%), Positives = 245/514 (47%), Gaps = 30/514 (5%)
Query: 5 RRVELYDTTLRDGSQMEGISFSLEDKLKITEKLDEFGIHYIEGGWPGSNPKDIQYFKAVR 64
R++E +DT+LRDG Q G+SFS+ +K+ I ++L+++ I IE G+ ++P + K +
Sbjct: 54 RKIEFFDTSLRDGEQTPGVSFSISEKVTIAKQLEKWRISVIEAGFSAASPDSFEAVKQIA 113
Query: 65 DLPLENAKIAAFGSTRRPRLRPEEDPNLNALVESEAPIATIFGKSWDLHVTEALRTTLEN 124
D L + + A + + D + A+ ++ P +F + +H+ L+ + E
Sbjct: 114 D-SLNDTAVTALARC----VISDIDKAVEAVKGAKYPQIHVFIATSPIHMKYKLKISPEE 168
Query: 125 NIQMIIDSIEYLRDHGMVVFYDAEHFFDGYRENPEYAMKTIKAAEEAGAERIVLADTNGG 184
++ I + Y R+ VV + E D R + ++ ++ A +AGA I + DT G
Sbjct: 169 VLKNIDKCVRYARERVEVVEFSPE---DATRTELNFLLEAVQTAVDAGATYINIPDTVGY 225
Query: 185 SLPS----FIKEVVEKVKEEVKTPLGIHAHNDSELAVANSLIAFEAGVVQIQGTINGYGE 240
+ P K +++ K + + H H+D +AVANSL A +AG +++GT+NG GE
Sbjct: 226 TTPEEYGKIFKFLIDNTKSDREIIFSPHCHDDLGMAVANSLAAIKAGAGRVEGTVNGIGE 285
Query: 241 RCGNANLISIIPALEL-KYGVEVVGKERLRKLKELAHFVAELANMEIPRNQPYVGDSAFA 299
R GNA L I AL + K + +L + A +++ + + IP+N+ VG +AFA
Sbjct: 286 RAGNAALEEIAVALHIRKDFYQAQSPLKLSETAATAELISQFSGIAIPKNKAIVGANAFA 345
Query: 300 HKGGVHVSAVLKNPRTYEHIDPELVG-NRRKVVVSELSGRSNLIYKAKELGIELEERDIK 358
H+ G+H VLKN TYE I PELVG + + +LSGR K EL I ++ +
Sbjct: 346 HESGIHQDGVLKNAETYEIITPELVGIKHNSLPLGKLSGRHAFSEKLTELNIAYDDESLA 405
Query: 359 RIVEEIKKLEFEGYHFEAAEASLELLIERLRGRYKPFFELERARVITEIFQGQPPISEAN 418
+ E+ KKL + E +A + L + F L+ ++ Q E
Sbjct: 406 ILFEKFKKLADK--KKEITDADIHALFTGETVKNLAGFILDNVQIDGHKALVQLKNQEEE 463
Query: 419 VVVRVNSRRVHTTAEGNGPVNALDLALRKALTKFYPELKEIKLVDYKVRVLGSEKGTAAK 478
+ V + EG+G V+A+ A+ K ++KL+ Y V + A
Sbjct: 464 IYV--------SQGEGSGSVDAIFKAIDKVFN------HQLKLISYSVDAVTDGIDAQAT 509
Query: 479 VRVLVQTSDGKKTWGTVGASTNIIEASLNAIMES 512
V V+ + G ++++ S A M +
Sbjct: 510 TLVSVENLSTGTIFNAKGVDYDVLKGSAIAYMNA 543
>sp|P94907|LEU1_MICAE 2-ISOPROPYLMALATE SYNTHASE (ALPHA-ISOPROPYLMALATE SYNTHASE)
(ALPHA-IPM SYNTHETASE) >gi|1783285|dbj|BAA12849.1|
(D85684) 2-isopropylmalate synthase [Microcystis
aeruginosa]
Length = 533
Score = 190 bits (477), Expect = 4e-47
Identities = 150/544 (27%), Positives = 261/544 (47%), Gaps = 50/544 (9%)
Query: 6 RVELYDTTLRDGSQMEGISFSLEDKLKITEKLDEFGIHYIEGGWPGSNPKDIQYFKAVRD 65
RV ++DTTLRDG Q G + ++++KL I L G+ IE G+P ++P D F+AV+
Sbjct: 7 RVIIFDTTLRDGEQSPGAALNVDEKLTIARALARLGVDVIEAGFPHASPGD---FEAVQK 63
Query: 66 LP------LENAKIAAFGSTRRPRLRPEEDPNLNALVESEAPIATIFGKSWDLHVTEALR 119
+ ++ I + ++ D AL + P F + D+H+ L+
Sbjct: 64 IAGSVGSEADSPIICGLARATQKDIKSAAD----ALRPAAKPRIHTFLATSDIHLQYKLK 119
Query: 120 TTLENNIQMIIDSIEYLRDHGMVVFYDAEHFFDGYRENPEYAMKTIKAAEEAGAERIVLA 179
T + ++++ + + Y + V + E D R +PE+ + ++ A AGA + +
Sbjct: 120 KTRQEVLEIVPEMVAYAKSFLNDVEFSPE---DAGRSDPEFLYQVLERAIAAGATTVNIP 176
Query: 180 DTNGGSLPSFIKEVVEKVKEEV----KTPLGIHAHNDSELAVANSLIAFEAGVVQIQGTI 235
DT G + PS ++ +KE V + + +H H+D LAVAN L A + G Q++ TI
Sbjct: 177 DTVGYTTPSEFGALIRGIKENVPNIDQAIISVHGHDDLGLAVANFLEAVKNGARQLECTI 236
Query: 236 NGYGERCGNANLISIIPALELK------------YGVEVVGKERLRKLKELAHFVAELAN 283
NG GER GNA+L ++ AL ++ E + K +++ + V+ L
Sbjct: 237 NGIGERAGNASLEELVMALHVRRSYFNPFLGRPAESTEPLTKINTKEIYRTSRLVSNLTG 296
Query: 284 MEIPRNQPYVGDSAFAHKGGVHVSAVLKNPRTYEHIDPELVG-NRRKVVVSELSGRSNLI 342
M + N+ VG +AFAH+ G+H VLK+ TYE +D E +G ++V+ +LSGR+
Sbjct: 297 MIVQPNKAIVGANAFAHESGIHQDGVLKHKLTYEIMDAESIGLTNNQIVLGKLSGRNAFR 356
Query: 343 YKAKELGIELEERDIKRIVEEIKKLEFEGYHFEAAEASLELLIERLRGRYKPFFELERAR 402
+ +ELG EL E ++ + K E E + LE ++ F LE
Sbjct: 357 SRLQELGFELSETELNNAFIQFK--EMADRKKEITDRDLEAIVNDEIDTVPDHFRLE--- 411
Query: 403 VITEIFQGQPPISEANVVVRV-NSRRVHTTAEGNGPVNALDLALRKALTKFYPELKEIKL 461
+ ++ G A V +R + + A G GPV+AL A+ + + P +L
Sbjct: 412 -LVQVSCGNNARPTATVTIRTPDGSELSDAAIGTGPVDALCKAIDRVVQ--IPN----EL 464
Query: 462 VDYKVRVLGSEKGTAAKVRVLVQTSDGKKTWGTVGASTNIIEASLNAIMESME--YWLMK 519
+ + VR + +G A V ++ +T+ A T+II AS A + ++ + ++
Sbjct: 465 ISFSVREV--TEGIDALGEVTIRLRYAGRTYSARAADTDIIVASARAYVSALNRLHVALQ 522
Query: 520 EREK 523
++EK
Sbjct: 523 QKEK 526
>sp|P48576|LEU1_SYNY3 2-ISOPROPYLMALATE SYNTHASE (ALPHA-ISOPROPYLMALATE SYNTHASE)
(ALPHA-IPM SYNTHETASE) >gi|7447052|pir||S76101
hypothetical protein - Synechocystis sp. (strain PCC
6803) >gi|1001454|dbj|BAA10079.1| (D63999)
2-isopropylmalate synthase [Synechocystis sp.]
Length = 533
Score = 189 bits (474), Expect = 9e-47
Identities = 152/531 (28%), Positives = 253/531 (47%), Gaps = 47/531 (8%)
Query: 6 RVELYDTTLRDGSQMEGISFSLEDKLKITEKLDEFGIHYIEGGWPGSNPKDIQYF-KAVR 64
R+ ++DTTLRDG Q G + ++E+KL I L G+ IE G+P ++P D + K +
Sbjct: 7 RILIFDTTLRDGEQSPGATLTVEEKLSIARALARLGVDIIEAGFPFASPGDFEAVQKIAQ 66
Query: 65 DLPLENAKIAAFGSTRRPRLRPEEDPNLNALVESEAPIAT----IFGKSWDLHVTEALRT 120
+ EN + L ++ A E+ P A F + D+H+ L+
Sbjct: 67 TVGTENGPVIC-------GLARATQKDIKAAAEALKPAAKHRIHTFLATSDIHLEHKLKK 119
Query: 121 TLENNIQMIIDSIEYLRDHGMVVFYDAEHFFDGYRENPEYAMKTIKAAEEAGAERIVLAD 180
T + ++ + + Y + + + E D R +PE+ + ++AA AGA I + D
Sbjct: 120 TRAEVLAIVPEMVAYAKSLVNDIEFSPE---DAGRSDPEFLYQVLEAAISAGATTINIPD 176
Query: 181 TNGGSLPS----FIKEVVEKVKEEVKTPLGIHAHNDSELAVANSLIAFEAGVVQIQGTIN 236
T G + P+ IK + + V + + +H HND LAVAN L A + G Q++ TIN
Sbjct: 177 TVGYTTPAEYGALIKGIADNVPNIDQAIISVHGHNDLGLAVANFLEAVKNGARQLECTIN 236
Query: 237 GYGERCGNANLISIIPALELK--YGVEVVGKER----------LRKLKELAHFVAELANM 284
G GER GNA L ++ AL ++ Y +G+ + + + V+EL M
Sbjct: 237 GIGERAGNAALEELVMALHVRRSYFNPFLGRPADSTAPLTNIDTKHIYATSRLVSELTGM 296
Query: 285 EIPRNQPYVGDSAFAHKGGVHVSAVLKNPRTYEHIDPELVG-NRRKVVVSELSGRSNLIY 343
+ N+ VG +AFAH+ G+H VLKN TYE +D E +G ++V+ +LSGR+
Sbjct: 297 MVQPNKAIVGANAFAHESGIHQDGVLKNKLTYEIMDAESIGLTNNQIVLGKLSGRNAFGT 356
Query: 344 KAKELGIELEERDIKRIVEEIKKLEFEGYHFEAAEASLELLIERLRGRYKPFFELERARV 403
+ KELG +L + ++ K E E + LE ++ + F LER +V
Sbjct: 357 RLKELGFDLSDTELNNAFIRFK--EVADKRKEITDWDLEAIVNDEIRQPPELFRLERVQV 414
Query: 404 ITEIFQGQPPISEANVVVRVNSRRVHT-TAEGNGPVNALDLALRKALTKFYPELKEIKLV 462
G+P + A + +R + T A G GPV+A+ A+ + + P +L+
Sbjct: 415 SC----GEPSVPTATLTIRTPAGPEETAVAIGTGPVDAVYKAINQIVQ--LPN----ELL 464
Query: 463 DYKVRVLGSEKGTAAKVRVLVQTSDGKKTWGTVGASTNIIEASLNAIMESM 513
+Y V + +G A +V V+ + A+T+II AS A + ++
Sbjct: 465 EYSVTSV--TEGIDALGKVSVRLRHNGVIYTGYAANTDIIVASARAYLGAL 513
>pir||E64106 2-isopropylmalate synthase (EC 4.1.3.12) - Haemophilus influenzae
(strain Rd KW20) >gi|1574015|gb|AAC22647.1| (U32779)
2-isopropylmalate synthase (leuA) [Haemophilus
influenzae Rd]
Length = 531
Score = 188 bits (472), Expect = 2e-46
Identities = 147/521 (28%), Positives = 268/521 (51%), Gaps = 30/521 (5%)
Query: 1 MLMKRRVELYDTTLRDGSQMEGISFSLEDKLKITEKLDEFGIHYIEGGWPGSNPKDIQYF 60
++M RV ++DTTLRDG Q S ++++KL+I L+ G+ +E G+P S+ D +
Sbjct: 15 IVMTDRVIIFDTTLRDGEQALKASLTVKEKLQIALALERLGVDVMEVGFPVSSQGDFESV 74
Query: 61 KAVRDLPLENAKIAAFGSTRRPRLRPEEDPNLNALVESEAPIATIFGKSWDLHVTEALRT 120
+ + ++NA++AA + + D AL +EA F S LHV L+
Sbjct: 75 QTIAR-HIKNARVAALSRA----VDKDIDAAYEALKVAEAFRIHTFIASSALHVEAKLKR 129
Query: 121 TLENNIQMIIDSIEYLRDHGMVVFYDAEHFFDGYRENPEYAMKTIKAAEEAGAERIVLAD 180
+ ++ + M + +++ R++ V + E D R + + ++AA AGA + + D
Sbjct: 130 SFDDVVGMAVAAVKRARNYTDDVEFSCE---DAGRTGIDNICRIVEAAINAGATTVNIPD 186
Query: 181 TNGGSLPSFIKEVVEKVKEEV----KTPLGIHAHNDSELAVANSLIAFEAGVVQIQGTIN 236
T G LP+ ++ +V+ V K + +H HND +A ANSL A + G QI+ TIN
Sbjct: 187 TVGFCLPNEYGNIIAQVRNCVPNIDKAVISVHCHNDLGMATANSLTAVQNGARQIECTIN 246
Query: 237 GYGERCGNANLISIIPALELKYGVEVVGKE-RLRKLKELAHFVAELANMEIPRNQPYVGD 295
G GER GN +L ++ A++++ V +++ ++ V++L NM I N+ VG
Sbjct: 247 GIGERAGNTSLEEVVMAMKVRQDFMGVDTHINTQEIHRVSQMVSQLCNMPIQPNKAIVGS 306
Query: 296 SAFAHKGGVHVSAVLKNPRTYEHIDPELVG-NRRKVVVSELSGRSNLIYKAKELGIELEE 354
+AFAH G+H +LKN TYE + PE +G + K+ ++ SGR+ + ++G ++
Sbjct: 307 NAFAHSSGIHQDGMLKNKNTYEILSPETIGLKKEKLNLTARSGRAAVKGHMADMGYNEQD 366
Query: 355 RDIKRIVEEIKKL-EFEGYHFEAAEASLELLIERLRGRYKPFFELERARVITEIFQGQPP 413
D+ ++ +E KL + +G F+ +L + + + + A E
Sbjct: 367 YDLDKLYDEFLKLADKKGQVFDYDLEALAFIDMQQGDEDRLVLDKLSAHSTKEY------ 420
Query: 414 ISEANVVVRVNSRRVHTTA-EGNGPVNALDLALRKALTKFYPELKEIKLVDYKVRVLGSE 472
+ A V ++++ ++ T++ GNGPV+A+ A+ LT EIK+ Y + G
Sbjct: 421 PATAFVQLKLDGEKLSTSSIGGNGPVDAVYNAILN-LTGL-----EIKMSHYNLTAKGEG 474
Query: 473 KGTAAKVRVLVQTSDGKKTWGTVGASTNIIEASLNAIMESM 513
+V ++V+ G+K G VG +T+I+E+S A++ ++
Sbjct: 475 AEALGQVDIVVE-HKGRKFHG-VGLATDIVESSALALVHAI 513
>gi|10954450 isopropylmalate synthase [Buchnera aphidicola]
>gi|3282732|gb|AAD12593.1| (AF041836) isopropylmalate
synthase [Buchnera aphidicola]
Length = 518
Score = 188 bits (472), Expect = 2e-46
Identities = 152/536 (28%), Positives = 272/536 (50%), Gaps = 39/536 (7%)
Query: 3 MKRRVELYDTTLRDGSQMEGISFSLEDKLKITEKLDEFGIHYIEGGWPGSNPKDIQYFKA 62
M +V ++DTTLRDG Q S S++ KL+I L+ GI IE G+P S+P D FK+
Sbjct: 1 MNSQVIIFDTTLRDGEQALQASLSVKQKLQIALSLENAGIDIIEVGFPISSPGD---FKS 57
Query: 63 VRDLP--LENAKIAAFGSTRRPRLRPEEDPNLNALVESEAPIATIFGKSWDLHVTEALRT 120
V+ + ++N++I + L + D A+ S IF + LH+ L+
Sbjct: 58 VQTISKNIKNSRICSLARC----LNKDIDTAAEAMSSSNTFRIHIFLATSTLHMESKLKK 113
Query: 121 TLENNIQMIIDSIEYLRDHGMVVFYDAEHFFDGYRENPEYAMKTIKAAEEAGAERIVLAD 180
+ I M I S++ + V + E D R + + ++ +AG + I + D
Sbjct: 114 NFDQIIDMAISSVKRALRYTDDVEFSCE---DASRTTMDNLCRIVEQLIKAGVKTINIPD 170
Query: 181 TNGGSLPSFIKEVVEKVKEEV----KTPLGIHAHNDSELAVANSLIAFEAGVVQIQGTIN 236
T G ++P+ + ++ + + V ++ + +H HND +AV NS+ A +AG QI+GTIN
Sbjct: 171 TVGYTVPNELSTIIHNLFKRVPNIDQSIISVHCHNDLGMAVGNSISAIQAGARQIEGTIN 230
Query: 237 GYGERCGNANLISIIPALELKYGVEVVGKERLRKLKEL---AHFVAELANMEIPRNQPYV 293
G GER GN L +I A++++ +++G K KE+ + ++++ N+ IP N+ V
Sbjct: 231 GIGERAGNTALEEVIMAIKVR--EDILGVSTNIKHKEIYRTSQIISQICNLPIPPNKAIV 288
Query: 294 GDSAFAHKGGVHVSAVLKNPRTYEHIDPELVGNRR-KVVVSELSGRSNLIYKAKELGIEL 352
G +AFAH G+H VLKN + YE ++P +G + K+ ++ SGR+ + Y ++G +
Sbjct: 289 GSNAFAHSSGIHQDGVLKNRKNYEIMEPSSIGLKEVKLNLTSRSGRAAVKYYMTQMGYKE 348
Query: 353 EERDIKRIVEEIKKL-EFEGYHFEAAEASLELLIERLRGRYKPFFELERARVITEIFQGQ 411
+ +I + KL + +G F+ +L + ++ +F L V I G
Sbjct: 349 CDYNIDELYTSFLKLADKKGQVFDYDLEALAFI--NMQQEESEYFSLSFFSV-QSISNG- 404
Query: 412 PPISEANVVVRVNSR-RVHTTAEGNGPVNALDLALRKALTKFYPELKEIKLVDYKVRVLG 470
+S A+V + + + + NGP++A+ AL + +T F I L Y++ G
Sbjct: 405 --LSTASVKLLCGKKVSIESATTSNGPIDAIYQALNR-ITNF-----PITLQKYQLVAKG 456
Query: 471 SEKGTAAKVRVLVQTSDGKKTWGTVGASTNIIEASLNAIMESMEYWLMKEREKDEK 526
+ +V +LV+ K+ + VG +T+IIE+S A++ + + K + +EK
Sbjct: 457 KGRDALGQVDILVEYK--KRKFHGVGLATDIIESSAQAMVNVLNN-IWKANQVNEK 509
>sp|P43861|LEU1_HAEIN 2-ISOPROPYLMALATE SYNTHASE (ALPHA-ISOPROPYLMALATE SYNTHASE)
(ALPHA-IPM SYNTHETASE)
Length = 515
Score = 187 bits (470), Expect = 3e-46
Identities = 147/519 (28%), Positives = 266/519 (50%), Gaps = 30/519 (5%)
Query: 3 MKRRVELYDTTLRDGSQMEGISFSLEDKLKITEKLDEFGIHYIEGGWPGSNPKDIQYFKA 62
M RV ++DTTLRDG Q S ++++KL+I L+ G+ +E G+P S+ D + +
Sbjct: 1 MTDRVIIFDTTLRDGEQALKASLTVKEKLQIALALERLGVDVMEVGFPVSSQGDFESVQT 60
Query: 63 VRDLPLENAKIAAFGSTRRPRLRPEEDPNLNALVESEAPIATIFGKSWDLHVTEALRTTL 122
+ ++NA++AA + + D AL +EA F S LHV L+ +
Sbjct: 61 IAR-HIKNARVAALSRA----VDKDIDAAYEALKVAEAFRIHTFIASSALHVEAKLKRSF 115
Query: 123 ENNIQMIIDSIEYLRDHGMVVFYDAEHFFDGYRENPEYAMKTIKAAEEAGAERIVLADTN 182
++ + M + +++ R++ V + E D R + + ++AA AGA + + DT
Sbjct: 116 DDVVGMAVAAVKRARNYTDDVEFSCE---DAGRTGIDNICRIVEAAINAGATTVNIPDTV 172
Query: 183 GGSLPSFIKEVVEKVKEEV----KTPLGIHAHNDSELAVANSLIAFEAGVVQIQGTINGY 238
G LP+ ++ +V+ V K + +H HND +A ANSL A + G QI+ TING
Sbjct: 173 GFCLPNEYGNIIAQVRNCVPNIDKAVISVHCHNDLGMATANSLTAVQNGARQIECTINGI 232
Query: 239 GERCGNANLISIIPALELKYGVEVVGKE-RLRKLKELAHFVAELANMEIPRNQPYVGDSA 297
GER GN +L ++ A++++ V +++ ++ V++L NM I N+ VG +A
Sbjct: 233 GERAGNTSLEEVVMAMKVRQDFMGVDTHINTQEIHRVSQMVSQLCNMPIQPNKAIVGSNA 292
Query: 298 FAHKGGVHVSAVLKNPRTYEHIDPELVG-NRRKVVVSELSGRSNLIYKAKELGIELEERD 356
FAH G+H +LKN TYE + PE +G + K+ ++ SGR+ + ++G ++ D
Sbjct: 293 FAHSSGIHQDGMLKNKNTYEILSPETIGLKKEKLNLTARSGRAAVKGHMADMGYNEQDYD 352
Query: 357 IKRIVEEIKKL-EFEGYHFEAAEASLELLIERLRGRYKPFFELERARVITEIFQGQPPIS 415
+ ++ +E KL + +G F+ +L + + + + A E +
Sbjct: 353 LDKLYDEFLKLADKKGQVFDYDLEALAFIDMQQGDEDRLVLDKLSAHSTKEY------PA 406
Query: 416 EANVVVRVNSRRVHTTA-EGNGPVNALDLALRKALTKFYPELKEIKLVDYKVRVLGSEKG 474
A V ++++ ++ T++ GNGPV+A+ A+ LT EIK+ Y + G
Sbjct: 407 TAFVQLKLDGEKLSTSSIGGNGPVDAVYNAILN-LTGL-----EIKMSHYNLTAKGEGAE 460
Query: 475 TAAKVRVLVQTSDGKKTWGTVGASTNIIEASLNAIMESM 513
+V ++V+ G+K G VG +T+I+E+S A++ ++
Sbjct: 461 ALGQVDIVVE-HKGRKFHG-VGLATDIVESSALALVHAI 497
>emb|CAA07305.2| (AJ006878) 2-isoproylmalate synthase [Buchnera aphidicola]
Length = 519
Score = 187 bits (470), Expect = 3e-46
Identities = 150/535 (28%), Positives = 273/535 (50%), Gaps = 35/535 (6%)
Query: 3 MKRRVELYDTTLRDGSQMEGISFSLEDKLKITEKLDEFGIHYIEGGWPGSNPKDIQYFKA 62
MK +V ++DTTLRDG Q S S+++KL+I L++ GI +E G+P S+P D FK+
Sbjct: 1 MKSKVVIFDTTLRDGEQALQASLSVKEKLQIALSLEKCGIDILEIGFPVSSPGD---FKS 57
Query: 63 VRDLP--LENAKIAAFGSTRRPRLRPEEDPNLNALVESEAPIATIFGKSWDLHVTEALRT 120
V+ + ++N++I + + + D A+ S++ IF + LH+ L+
Sbjct: 58 VQTISKNIKNSRICSLARC----IEKDIDAAGEAMSSSDSFRIHIFLATSTLHMESKLKK 113
Query: 121 TLENNIQMIIDSIEYLRDHGMVVFYDAEHFFDGYRENPEYAMKTIKAAEEAGAERIVLAD 180
I M + S++ + + + E D R + + ++ ++G + I + D
Sbjct: 114 NFNEIIDMAVFSVKKALRYTDDIEFSCE---DATRTTMDNLCRIVETLIKSGVKTINIPD 170
Query: 181 TNGGSLPS----FIKEVVEKVKEEVKTPLGIHAHNDSELAVANSLIAFEAGVVQIQGTIN 236
T G ++P+ IK ++E+V K+ + +H H+D +AV NS+ A +AG QI+GTIN
Sbjct: 171 TVGYTVPNELSCIIKNLLERVPNIHKSIISVHCHDDLGMAVGNSISAIQAGARQIEGTIN 230
Query: 237 GYGERCGNANLISIIPALELKYGVEVVGKE-RLRKLKELAHFVAELANMEIPRNQPYVGD 295
G GER GN L II A++++ + V +++ + V+++ NM IP N+ VG
Sbjct: 231 GIGERAGNTALEEIIMAIKVREDILSVSTNINYKEIYRTSKIVSQICNMPIPSNKAIVGS 290
Query: 296 SAFAHKGGVHVSAVLKNPRTYEHIDPELVGNRR-KVVVSELSGRSNLIYKAKELGIELEE 354
+AFAH G+H VLKN + YE ++P +G + K+ ++ SGR+ + + E+G +
Sbjct: 291 NAFAHSSGIHQDGVLKNRKNYEIMEPSSIGLKEVKLNLTSRSGRAAVKHYMDEMGYNNSD 350
Query: 355 RDIKRI-VEEIKKLEFEGYHFEAAEASLELLIERLRGRYKPFFELERARVITEIFQGQPP 413
+I + + +K + +G F+ +L I + + ++ +F L+ +
Sbjct: 351 YNIDELYIAFLKLADKKGQVFDYDLEAL-AFINKQQDEWE-YFSLK----FFSVQSISNS 404
Query: 414 ISEANVVVRVNSRR-VHTTAEGNGPVNALDLALRKALTKFYPELKEIKLVDYKVRVLGSE 472
+S A+V + + ++ NGPV+A+ AL + +P I L +++ G
Sbjct: 405 LSTASVKLLCGKKTYTESSTTSNGPVDAIYQALNRIAC--FP----IILQKFQLVAKGKG 458
Query: 473 KGTAAKVRVLVQTSDGKKTWGTVGASTNIIEASLNAIMESM-EYWLMKEREKDEK 526
K +V +LV+ K+ + VG +T+IIEAS A++ + W K+ K K
Sbjct: 459 KDALGQVDILVEHK--KRKFHGVGLATDIIEASAQAMINVLNNIWKAKQVNKKLK 511
>gi|10957107 2-isopropylmalate synthase [Buchnera sp. APS]
>gi|11182435|sp|Q9ZEY8|LEU1_BUCAI 2-ISOPROPYLMALATE
SYNTHASE (ALPHA-ISOPROPYLMALATE SYNTHASE) (ALPHA-IPM
SYNTHETASE) >gi|7707821|dbj|BAA95423.1| (AP001071)
2-isopropylmalate synthase [Buchnera sp. APS]
Length = 519
Score = 187 bits (469), Expect = 3e-46
Identities = 151/535 (28%), Positives = 271/535 (50%), Gaps = 35/535 (6%)
Query: 3 MKRRVELYDTTLRDGSQMEGISFSLEDKLKITEKLDEFGIHYIEGGWPGSNPKDIQYFKA 62
MK +V ++DTTLRDG Q S S+++KL+I L++ GI +E G+P S+P D FK+
Sbjct: 1 MKSKVVIFDTTLRDGEQALQASLSVKEKLQIALSLEKCGIDILEIGFPVSSPGD---FKS 57
Query: 63 VRDLP--LENAKIAAFGSTRRPRLRPEEDPNLNALVESEAPIATIFGKSWDLHVTEALRT 120
V+ + ++N++I + + + D A+ S++ IF + LH+ L+
Sbjct: 58 VQTISKNIKNSRICSLARC----IEKDIDAAGEAMSSSDSFRIHIFLATSTLHMESKLKK 113
Query: 121 TLENNIQMIIDSIEYLRDHGMVVFYDAEHFFDGYRENPEYAMKTIKAAEEAGAERIVLAD 180
I M + S++ + + + E D R + + ++ ++G + I + D
Sbjct: 114 NFNEIIDMAVFSVKKALRYTDDIEFSCE---DATRTTMDNLCRIVETLIKSGVKTINIPD 170
Query: 181 TNGGSLPS----FIKEVVEKVKEEVKTPLGIHAHNDSELAVANSLIAFEAGVVQIQGTIN 236
T G ++P+ IK + E+V K+ + +H H+D +AV NS+ A +AG QI+GTIN
Sbjct: 171 TVGYTVPNELSCIIKNLFERVPNIHKSIISVHCHDDLGMAVGNSISAIQAGARQIEGTIN 230
Query: 237 GYGERCGNANLISIIPALELKYGVEVVGKE-RLRKLKELAHFVAELANMEIPRNQPYVGD 295
G GER GN L II A++++ + V +++ + V+++ NM IP N+ VG
Sbjct: 231 GIGERAGNTALEEIIMAIKVREDILSVSTNINYKEIYRTSKIVSQICNMPIPSNKAIVGS 290
Query: 296 SAFAHKGGVHVSAVLKNPRTYEHIDPELVGNRR-KVVVSELSGRSNLIYKAKELGIELEE 354
+AFAH G+H VLKN + YE ++P +G + K+ ++ SGR+ + + E+G +
Sbjct: 291 NAFAHSSGIHQDGVLKNRKNYEIMEPSSIGLKEVKLNLTSRSGRAAVKHYMDEMGYNNSD 350
Query: 355 RDIKRIVEEIKKL-EFEGYHFEAAEASLELLIERLRGRYKPFFELERARVITEIFQGQPP 413
+I + KL + +G F+ +L I + + ++ +F L+ +
Sbjct: 351 YNIDELYTAFLKLADKKGQVFDYDLEAL-AFINKQQDEWE-YFSLK----FFSVQSISNS 404
Query: 414 ISEANVVVRVNSRR-VHTTAEGNGPVNALDLALRKALTKFYPELKEIKLVDYKVRVLGSE 472
+S A+V + + ++ NGPV+A+ AL + +P I L +++ G
Sbjct: 405 LSTASVKLLCGKKTYTESSTTSNGPVDAIYQALNRIAC--FP----IILQKFQLVAKGKG 458
Query: 473 KGTAAKVRVLVQTSDGKKTWGTVGASTNIIEASLNAIMESM-EYWLMKEREKDEK 526
K +V +LV+ K+ + VG +T+IIEAS A++ + W K+ K K
Sbjct: 459 KDALGQVDILVEHK--KRKFHGVGLATDIIEASAQAMINVLNNIWKAKQVNKKLK 511
>sp|P48571|LEU1_BUCRP 2-ISOPROPYLMALATE SYNTHASE (ALPHA-ISOPROPYLMALATE SYNTHASE)
(ALPHA-IPM SYNTHETASE) >gi|899388|emb|CAA50615.1|
(X71612) 2-isopropylmalate synthase [Buchnera
aphidicola]
Length = 518
Score = 186 bits (467), Expect = 6e-46
Identities = 155/537 (28%), Positives = 269/537 (49%), Gaps = 41/537 (7%)
Query: 3 MKRRVELYDTTLRDGSQMEGISFSLEDKLKITEKLDEFGIHYIEGGWPGSNPKDIQYFKA 62
M +V ++DTTLRDG Q S S++ KL+I L+ GI IE G+P S+P D FK+
Sbjct: 1 MNSQVIIFDTTLRDGEQALQASLSVKQKLQIALSLENTGIDIIEVGFPISSPGD---FKS 57
Query: 63 VRDLP--LENAKIAAFGSTRRPRLRPEEDPNLNALVESEAPIATIFGKSWDLHVTEALRT 120
V+ + ++N++I + L + D A+ S A IF + LH+ L+
Sbjct: 58 VQTISKNIKNSRICSLARC----LDKDIDAAAEAMHSSNAFRIHIFLATSILHMESKLKK 113
Query: 121 TLENNIQMIIDSIEYLRDHGMVVFYDAEHFFDGYRENPEYAMKTIKAAEEAGAERIVLAD 180
+ I M I S++ + V + E D R + + ++ AG + I + D
Sbjct: 114 NFDQIIDMAITSVKRALRYTDDVEFSCE---DASRTTMDNLCRIVEKLINAGVKTINIPD 170
Query: 181 TNGGSLPSFIKEVVEKVKEEV----KTPLGIHAHNDSELAVANSLIAFEAGVVQIQGTIN 236
T G ++P+ + ++ + + V K+ + +H HND +AV NS+ A +AG QI+GTIN
Sbjct: 171 TVGYTVPNELSSIIHNLFQRVPNIDKSIISVHCHNDLGMAVGNSISAIQAGARQIEGTIN 230
Query: 237 GYGERCGNANLISIIPALELKYGV-EVVGKERLRKLKELAHFVAELANMEIPRNQPYVGD 295
G GER GN L +I A++++ V V K + +++ + ++++ N+ IP N+ VG
Sbjct: 231 GIGERAGNTALEEVIIAIKVREDVLGVSTKIKHKEIYRTSQIISQICNLPIPPNKAIVGS 290
Query: 296 SAFAHKGGVHVSAVLKNPRTYEHIDPELVGNRR-KVVVSELSGRSNLIYKAKELGIELEE 354
+AFAH G+H VLKN + YE ++P +G + K+ ++ SGR+ + + E+G +
Sbjct: 291 NAFAHSSGIHQDGVLKNRKNYEIMEPSSIGLKEVKLNLTSRSGRAAVKHYMTEMGYRECD 350
Query: 355 RDIKRIVEEIKKL-EFEGYHFE---AAEASLELLIERLRGRYKPFFELERARVITEIFQG 410
I + KL + +G F+ A A + E L FF ++ I G
Sbjct: 351 YKIDELYASFLKLADKKGQVFDYDLEALAFINQQQEELEHFSLSFFSVQ------SISNG 404
Query: 411 QPPISEANVVVRVNSRR-VHTTAEGNGPVNALDLALRKALTKFYPELKEIKLVDYKVRVL 469
+S A+V + + + + NGP++A+ AL + +T F I L Y++
Sbjct: 405 ---LSTASVKLLCGKKTFIESATTSNGPIDAIYQALNR-ITHF-----PIILQKYQLIAK 455
Query: 470 GSEKGTAAKVRVLVQTSDGKKTWGTVGASTNIIEASLNAIMESMEYWLMKEREKDEK 526
G K +V +LV+ K+ + +G +T+IIE+S A++ + + K + +EK
Sbjct: 456 GKGKDALGQVDILVEHK--KRKFHGMGLATDIIESSAQAMVNVLNN-IWKANQVNEK 509
>pir||F82070 2-isopropylmalate synthase VC2490 [imported] - Vibrio cholerae
(group O1 strain N16961) >gi|9657070|gb|AAF95632.1|
(AE004318) 2-isopropylmalate synthase [Vibrio cholerae]
Length = 516
Score = 185 bits (464), Expect = 1e-45
Identities = 149/518 (28%), Positives = 260/518 (49%), Gaps = 36/518 (6%)
Query: 3 MKRRVELYDTTLRDGSQMEGISFSLEDKLKITEKLDEFGIHYIEGGWPGSNPKDIQYFKA 62
M +V ++DTTLRDG Q S ++++KL+I L+ G+ IE G+P S+P D + +
Sbjct: 1 MNNQVIIFDTTLRDGEQALSASLTVKEKLQIAYALERLGVDIIEAGFPVSSPGDFESVQT 60
Query: 63 VRDLPLENAKIAAFGSTRRPRLRPEEDPNLNALVESEAPIATIFGKSWDLHVTEALRTTL 122
+ ++N+++ A + + D AL +EA F + +HV + LR +
Sbjct: 61 IAK-NIKNSRVCALSRA----VAKDIDAAAEALKVAEAFRIHTFISTSTIHVQDKLRRSY 115
Query: 123 ENNIQMIIDSIEYLRDHGMVVFYDAEHFFDGYRENPEYAMKTIKAAEEAGAERIVLADTN 182
++ + M + ++++ R + V + E D R + + ++AA AGA I + DT
Sbjct: 116 DDVVAMAVKAVKHARQYTDDVEFSCE---DAGRTPIDNLCRMVEAAINAGARTINIPDTV 172
Query: 183 GGSLPS----FIKEVVEKVKEEVKTPLGIHAHNDSELAVANSLIAFEAGVVQIQGTINGY 238
G ++PS I+ + +V K + +H H+D ++VANS+ A +AG Q++GTING
Sbjct: 173 GYTVPSEFGGIIQTLFNRVPNIDKAIISVHCHDDLGMSVANSIAAIQAGARQVEGTINGI 232
Query: 239 GERCGNANLISIIPALELKYGVEVVGKERLRKLKELAH---FVAELANMEIPRNQPYVGD 295
GER GN L I A+ +K E++G K E++ V++L NM I N+ VG
Sbjct: 233 GERAGNCALEEI--AMIIKTRQELLGVTTGIKHDEISRTSKLVSQLCNMPIQSNKAIVGA 290
Query: 296 SAFAHKGGVHVSAVLKNPRTYEHIDPELVGNRRKVV-VSELSGRSNLIYKAKELGIELEE 354
+AF+H G+H +LKN TYE + PE +G + + + ++ SGR+ + +G E
Sbjct: 291 NAFSHSSGIHQDGMLKNKNTYEIMTPESIGLKNQALNLTSRSGRAAVKSHMDSMGYNENE 350
Query: 355 RDIKRIVEEIKKL-EFEGYHFEAAEASLELLIERLRGRYK-PFFELERARVITEIFQGQP 412
++ + E+ KL + +G F + LE L+ R + F++L V Q
Sbjct: 351 YNLDALYEDFLKLADRKGQVF---DYDLEALMHFSNLREEDDFYKLNYLSV-----QSGS 402
Query: 413 PISEANVVVRVNSRRVHTTAEGNGPVNALDLALRKALTKFYPELKEIKLVDYKVRVLGSE 472
++ ++ + A GNGPV+AL + + +T + EI L + + G
Sbjct: 403 VMATTSIKLLCGGEEKCEAAVGNGPVDALYQCIYR-ITGY-----EIVLDKFDLTAKGEG 456
Query: 473 KGTAAKVRVLVQTSDGKKTWGTVGASTNIIEASLNAIM 510
+ + ++ G+K GT G ST+I+EAS A++
Sbjct: 457 EDGLGQADIIANYK-GRKYHGT-GVSTDIVEASGQALL 492
>sp|P48575|LEU1_ANASP 2-ISOPROPYLMALATE SYNTHASE (ALPHA-ISOPROPYLMALATE SYNTHASE)
(ALPHA-IPM SYNTHETASE) >gi|1084180|pir||S52294
2-isopropylmalate synthase (EC 4.1.3.12) - Anabaena sp.
(PCC 7120) >gi|662867|emb|CAA87005.1| (Z46907)
alpha-isopropylmalate synthase [Anabaena PCC7120]
Length = 531
Score = 180 bits (452), Expect = 3e-44
Identities = 152/534 (28%), Positives = 259/534 (48%), Gaps = 53/534 (9%)
Query: 6 RVELYDTTLRDGSQMEGISFSLEDKLKITEKLDEFGIHYIEGGWPGSNPKDIQYFKAVRD 65
++ ++DTTLRDG Q G + ++++KL I ++L G+ IE G+ ++P D F+AV
Sbjct: 7 KIIIFDTTLRDGEQCPGATLNIDEKLAIAKQLARLGVDIIEAGFAFASPGD---FEAVH- 62
Query: 66 LPLENAKIA-AFGSTRRP---RLRPEEDPNLNALVESEAPIAT----IFGKSWDLHVTEA 117
KIA G+ P L ++ A E+ P A F + D+H+
Sbjct: 63 ------KIAQTVGTQSGPVICSLARARHDDIKAAAEAIKPAAKGRIHTFIATSDIHLQYK 116
Query: 118 LRTTLENNIQMIIDSIEYLRDHGMVVFYDAEHFFDGYRENPEYAMKTIKAAEEAGAERIV 177
L+ T I + + + Y + V + E D R +PE+ + ++ A AGA I
Sbjct: 117 LKKTRPEVIAIAEEMVAYAKSFTDDVEFSPE---DAGRSDPEFLYQVLERAIAAGATTIN 173
Query: 178 LADTNGGSLPSFIKEVVEKVKEEV----KTPLGIHAHNDSELAVANSLIAFEAGVVQIQG 233
+ DT G + PS +++ +KE V + + +H HND LAVAN L A + G Q++
Sbjct: 174 IPDTVGYTTPSEFGAIIKGIKENVPNIDQAIISVHGHNDLGLAVANFLEAVKNGARQLEC 233
Query: 234 TINGYGERCGNANLISIIPALELK-------YGVEVVGKERL-----RKLKELAHFVAEL 281
TING GER GNA L ++ A+ ++ G +E L +++ + + V+ L
Sbjct: 234 TINGIGERAGNAALEELVMAMHVRRQYFNPFLGRHPDSEEALTNIDTKQIYKTSRLVSNL 293
Query: 282 ANMEIPRNQPYVGDSAFAHKGGVHVSAVLKNPRTYEHIDPELVG-NRRKVVVSELSGRSN 340
M + N+ VG +AFAH+ G+H VLKN TYE +D +L+G ++V+ + SGR+
Sbjct: 294 TGMLVQPNKAIVGANAFAHESGIHQDGVLKNKLTYEIMDAQLIGLTDNQIVLGKHSGRNA 353
Query: 341 LIYKAKELGIELEERDIKRIVEEIKKLEFEGYHFEAAEASLELLIERLRGRYKPFFELER 400
+ KELG EL E ++ + + K E E ++ LE ++ + F +E
Sbjct: 354 FRTRLKELGFELSETELNKAFVKFK--EVADKKKEISDWDLEAIVNDEIQQAPDLFRVEL 411
Query: 401 ARVITEIFQGQPPISEANVVVRV-NSRRVHTTAEGNGPVNALDLALRKALTKFYPELKEI 459
+V QP A V +R + + A G GPV+A+ A+ + + P
Sbjct: 412 VQVSAVAMHVQP----ATVTLRTPDGEELTDAAIGTGPVDAVYKAINRVVN--VPN---- 461
Query: 460 KLVDYKVRVLGSEKGTAAKVRVLVQTSDGKKTWGTVGASTNIIEASLNAIMESM 513
+L+++ V+ + + G A V ++ + + A+T+II AS A + ++
Sbjct: 462 QLIEFSVQSVTA--GIDAIGEVTIRLRYESRVFSGHAANTDIIVASAQAYVNAL 513
>gb|AAK42554.1| 2-isopropylmalate synthase, putative (leuA-3) [Sulfolobus
solfataricus]
Length = 347
Score = 179 bits (449), Expect = 8e-44
Identities = 119/346 (34%), Positives = 183/346 (52%), Gaps = 25/346 (7%)
Query: 33 ITEKLDEFGIHYIEGGWPGSNPKDIQYFKAVRDLPLE-NAKIAAFGSTRRPRLRPEEDPN 91
I KL + G+ IE G+P S+ + F A R + E ++ G +R + +
Sbjct: 2 IARKLADLGVDVIEAGFPASSEGE---FIATRKIFEEIGDQVEVIGLSRSNK------ND 52
Query: 92 LNALVESEAPIATIFGKSWDLHVTEALRTTLENNIQMIIDSIEYLRDHGMVVFYDAEHFF 151
++ + + +F + +LH+ L+ T E + I +S++Y +DHGM+V + E
Sbjct: 53 IDKTISTGISSIHLFIATSELHMKYKLKMTKEEVLNKIYESVKYAKDHGMIVEFSPE--- 109
Query: 152 DGYRENPEYAMKTIKAAEEAGAERIVLADTNGGSLP----SFIKEVVEKVKEEVKTPLGI 207
D R ++ I+ A EAGA+RI + DT G P IK++V V E + + +
Sbjct: 110 DATRTEEDFLFTAIRTAIEAGADRINIPDTVGTMHPFKYYDMIKKIVNFVGERII--VSV 167
Query: 208 HAHNDSELAVANSLIAFEAGVVQIQGTINGYGERCGNANLISIIPALE--LKYGVEVVGK 265
H HND LA ANSL AG Q T+NG GER GNA+L ++ ++ L Y V
Sbjct: 168 HCHNDFGLATANSLAGVYAGARQAHVTVNGIGERAGNASLEEVVMGIKKLLNYETNV--- 224
Query: 266 ERLRKLKELAHFVAELANMEIPRNQPYVGDSAFAHKGGVHVSAVLKNPRTYEHIDPELVG 325
+ KL E++ FVAE+ + +P + VGD+AF H+ G+HV V++NP TYE I PE VG
Sbjct: 225 -KTWKLYEVSRFVAEMTGVPVPYFKAIVGDNAFGHESGIHVHGVIENPFTYEPISPEEVG 283
Query: 326 NRRKVVVSELSGRSNLIYKAKELGIELEERDIKRIVEEIKKLEFEG 371
N R++ + + SG L +E GI L + +K ++ EIKKL G
Sbjct: 284 NFRRLALGKHSGIHGLRKLLEEQGIYLSDDKLKIVLAEIKKLAESG 329
>pir||G75159 2-isopropylmalate synthase (leua-2) PAB0286 - Pyrococcus abyssi
(strain Orsay) >gi|5457868|emb|CAB49358.1| (AJ248284)
2-isopropylmalate synthase (leuA-2) [Pyrococcus abyssi]
Length = 361
Score = 178 bits (447), Expect = 1e-43
Identities = 111/340 (32%), Positives = 183/340 (53%), Gaps = 16/340 (4%)
Query: 11 DTTLRDGSQMEGISFSLEDKLKITEKLDEFGIHYIEGGWPGSNPKDIQYFKAVRDLPLEN 70
D+TLR+G Q G++++ E +L+I LDE G+ +IE G P + + K + + L N
Sbjct: 4 DSTLREGEQTPGVNYTPEQRLEIAIALDEVGVDFIEIGHPAVSEDVFRGMKLIAEQGL-N 62
Query: 71 AKIAAFGSTRRPRLRPEEDPNLNALVESEAPIATIFGKSWDLHVTEALRTTLENNIQMII 130
++ A R E+ ++ ++++ IF + + + R TL++ ++ I
Sbjct: 63 VELLAHS-----RALIED---IDYVLKTGVDWVGIFFCLSEACLRKRFRITLDHALEKIS 114
Query: 131 DSIEYLRDHGMVVFYDAEHFFDGYRENPEYAMKTIKAAEEAGAERIVLADTNGGSLPSFI 190
+IEY +DHG+ V + E D R + I+ A+E +RI +ADT G + P
Sbjct: 115 RAIEYAKDHGLKVRFTPE---DTTRTEWANLKRAIRLAKELKVDRISVADTTGSTHPLRF 171
Query: 191 KEVVEKVKEEVKTPLGIHAHNDSELAVANSLIAFEAGVVQIQGTINGYGERCGNANLISI 250
+V+K+ P+ +H HND LA+AN+++ EAG + T+NG GER G +L I
Sbjct: 172 YTLVKKIVN-FGIPVNVHCHNDLGLALANAIMGIEAGATLVDATVNGLGERAGIVDLAQI 230
Query: 251 IPALELKYGVEVVGKERLRKLKELAHFVAELANMEIPRNQPYVGDSAFAHKGGVHVSAVL 310
I L YG++ K RL L +++ V+E+ + N P VG++AF HK G+HVSAVL
Sbjct: 231 ITVLYYHYGIK---KYRLDLLYRVSNLVSEITGISPQPNYPIVGENAFTHKAGLHVSAVL 287
Query: 311 KNPRTYEHIDPELVGNRRKVVVSELSGRSNLIYKAKELGI 350
K+PR YE + E+ G R + V +G+ + Y ++ GI
Sbjct: 288 KDPRFYEFLPAEVFGRERTIYVDRYAGKDTIRYYLEKFGI 327
>pir||A82634 2-isopropylmalate synthase XF1818 [imported] - Xylella fastidiosa
(strain 9a5c) >gi|9106897|gb|AAF84624.1|AE004003_3
(AE004003) 2-isopropylmalate synthase [Xylella
fastidiosa]
Length = 519
Score = 178 bits (446), Expect = 2e-43
Identities = 152/517 (29%), Positives = 248/517 (47%), Gaps = 40/517 (7%)
Query: 6 RVELYDTTLRDGSQMEGISFSLEDKLKITEKLDEFGIHYIEGGWPGSNPKDIQYFKAVRD 65
R+ ++DTTLRDG Q G S + KL + LD G+ IE G+P S+ D + +
Sbjct: 11 RIRIFDTTLRDGEQSPGCSMPAQQKLVMARALDALGVDIIETGFPASSQSDYEAMTLIAR 70
Query: 66 LPLENAKIAAFGSTRRPRLRPEEDPNLNALVESEAPIATIFGKSWDLHVTEALRTTLENN 125
L +A L+ + + + AL + P +F + LH LR + E
Sbjct: 71 -ELRRPTLAVLSRC----LQADIETSARALESATKPRLHVFLSTSPLHREHKLRMSKEQV 125
Query: 126 IQMIIDSIEYLRDHGMVVFYDAEHFFDGYRENPEYAMKTIKAAEEAGAERIVLADTNGGS 185
++ + + R V + AE D R ++ ++ + A AGA I L DT G S
Sbjct: 126 LESVHKHVSLSRTLIDDVEFSAE---DATRTEEDFLIEVTRVAIAAGATTINLPDTVGFS 182
Query: 186 LPSFIKEVVEKVKEEV----KTPLGIHAHNDSELAVANSLIAFEAGVVQIQGTINGYGER 241
P I+ + ++ V K H H+D LAVANSL A E G QI+ TING GER
Sbjct: 183 TPEEIRNMFTRIIANVEGANKVIFSAHCHDDLGLAVANSLAAIEGGARQIECTINGIGER 242
Query: 242 CGNANLISIIPALELK---YGVEVVGKERLRKLKELAHFVAELANMEIPRNQPYVGDSAF 298
GN L + L+++ Y ++ ++ + + L M + RN+ VG +AF
Sbjct: 243 AGNCALEELTMVLKVRNAFYNIDT--SIHTSRIVSTSQLLQRLVGMPVQRNKAVVGANAF 300
Query: 299 AHKGGVHVSAVLKNPRTYEHIDPELVG-NRRKVVVSELSGRSNLIYKAKELGIELEERDI 357
AH+ G+H +L++ TYE + P+ VG +V+ SGR+ + + + LG LEE D+
Sbjct: 301 AHESGIHQHGMLRHRGTYEIMRPQEVGWVCSHMVLGRHSGRAAVEQRLRALGYLLEEEDL 360
Query: 358 KRIVEEIKKLEFEGYHFEAAEASLELLIERLRGRYKPFFELERARVITEIFQGQPPISEA 417
K + EE K+L E + L++L++ ++ + L + I++I + A
Sbjct: 361 KLVFEEFKQL-CEKQRL-VTDVDLQVLMQDTTVQHG--YRLA-SMTISDIG------NRA 409
Query: 418 NVVVRVNS---RRVHTTAEGNGPVNALDLALRKALTKFYPELKEIKLVDYKVRVLGSEKG 474
N +V ++ +RV TA+GNGPV+AL AL A +++L Y+V +G
Sbjct: 410 NALVELSDPQGQRVAETAQGNGPVDALFGALAAATG------VKLELDSYQVHSVGIGAD 463
Query: 475 TAAKVRVLVQTSDGKKTWGTVGASTNIIEASLNAIME 511
+ + V+ +D + + G S +IIEAS A ++
Sbjct: 464 ARGEANLSVRHNDTQ--YEGTGTSKDIIEASALAWLD 498
>pir||F75391 2-isopropylmalate synthase - Deinococcus radiodurans (strain R1)
>gi|6459240|gb|AAF11047.1|AE001992_7 (AE001992)
2-isopropylmalate synthase [Deinococcus radiodurans]
Length = 522
Score = 176 bits (443), Expect = 4e-43
Identities = 150/517 (29%), Positives = 241/517 (46%), Gaps = 32/517 (6%)
Query: 4 KRRVELYDTTLRDGSQMEGISFSLEDKLKITEKLDEFGIHYIEGGWPGSNPKDIQYFKAV 63
++ + ++DTTLRDG Q G++ + KL+I L G+ IE G+P ++P D++ +
Sbjct: 13 QQHIRIFDTTLRDGEQSPGVALNHAQKLEIAHTLARMGVDVIEAGFPIASPGDLEGVSRI 72
Query: 64 RDLPLENAKIAAFGSTRRPRLRPEEDPNLNALVESEAPIATIFGKSWDLHVTEALRTTLE 123
+ I A R + E ++ I T S +H+ + L +
Sbjct: 73 AR-EVRGPVITALARANRADI---EAAAKGVEAAEKSRIHTFIATS-PIHMQKKLNLEPD 127
Query: 124 NNIQMIIDSIEYLRDHGMVVFYDAEHFFDGYRENPEYAMKTIKAAEEAGAERIVLADTNG 183
I+ ++++ R + V + AE D R ++ + KAA EAGA I + DT G
Sbjct: 128 AVIERAVEAVRLARQYVDDVEFSAE---DATRSEWDFLSRIFKAAVEAGATTINVPDTVG 184
Query: 184 GSLPSFIKEVVEKVKEEVKTP--LGIHAHNDSELAVANSLIAFEAGVVQIQGTINGYGER 241
+ P ++++ +K ++ L H H+D +AVANS+ A E G QI+ TING GER
Sbjct: 185 YTTPEEMRKLFAYLKAKLPAHVILSSHCHDDLGMAVANSIAAAEGGARQIECTINGIGER 244
Query: 242 CGNANLISIIPALELKYGVEVVGKE---RLRKLKELAHFVAELANMEIPRNQPYVGDSAF 298
GNA+L I+ A + +V G E R R+L + V+ L+ M + N+ VGD+AF
Sbjct: 245 AGNASLEEIVMAFHTRR--DVYGYETGIRTRELYRASRLVSRLSGMPVQPNKAIVGDNAF 302
Query: 299 AHKGGVHVSAVLKNPRTYEHIDPELVGNRRKV-VVSELSGRSNLIYKAKELGI-ELEERD 356
AH+ G+H V+K TYE ++ ELVG V V+ + SGR+ +LG ++ +
Sbjct: 303 AHESGIHQDGVIKARETYEIMNAELVGREAAVLVMGKHSGRAAFRKALTDLGYGDIPDDK 362
Query: 357 IKRIVEEIKKLEFEGYHFEAAEASLELLIERLRGRYKPFFELERARVITEIFQGQPPISE 416
++ + K L A + L L++ R F LE +I G +
Sbjct: 363 VQHLFGRFKDLADRKGQIYAED--LRALVD-ARSDVPQTFSLEG----FQITSGMNMMPV 415
Query: 417 ANVVVRVNSRRVHTTAEGNGPVNALDLALRKALTKFYPELKEIKLVDYKVRVLGSEKGTA 476
A V + V TA G+GPV A A+ K +T P L+ R+ +G
Sbjct: 416 AFVRLHTPDGPVDATAHGDGPVEAAFQAISK-ITGISPTLE-------SYRIQSVTRGDD 467
Query: 477 AKVRVLVQTSDGKKTWGTVGASTNIIEASLNAIMESM 513
A V + G+ G +T+I+EAS A + M
Sbjct: 468 ALGEVSIHVRHGETQLNGTGVATDIVEASARAWIRVM 504
>pir||G81125 2-isopropylmalate synthase NMB1070 [imported] - Neisseria
meningitidis (group B strain MD58)
>gi|7226309|gb|AAF41465.1| (AE002457) 2-isopropylmalate
synthase [Neisseria meningitidis MC58]
Length = 517
Score = 175 bits (440), Expect = 9e-43
Identities = 141/531 (26%), Positives = 250/531 (46%), Gaps = 50/531 (9%)
Query: 1 MLMKRRVELYDTTLRDGSQMEGISFSLEDKLKITEKLDEFGIHYIEGGWPGSNPKDIQYF 60
M RV ++DTTLRDG Q G + + E+K+++ +L++ G+ IE G+ ++P D F
Sbjct: 1 MTQTNRVIIFDTTLRDGEQSPGAAMTKEEKIRVARQLEKLGVDIIEAGFAAASPGD---F 57
Query: 61 KAVRDLPLENAKIAAFGSTRRPRLRPEEDPNLNALVESEAPIATI--FGKSWDLHVTEAL 118
+AV + K +R E D + AP I F + +H+ L
Sbjct: 58 EAVNAIAKTITKSTVCSLSRAI----ERDIRQAGEAVAPAPKKRIHTFIATSPIHMEYKL 113
Query: 119 RTTLENNIQMIIDSIEYLRDHGMVVFYDAEHFFDGYRENPEYAMKTIKAAEEAGAERIVL 178
+ + I+ + +++ R++ V + E D R ++ + A EAGA I +
Sbjct: 114 KMKPKQVIEAAVKAVKIAREYTDDVEFSCE---DALRSEIDFLAEICGAVIEAGATTINI 170
Query: 179 ADTNGGSLP----SFIKEVVEKVKEEVKTPLGIHAHNDSELAVANSLIAFEAGVVQIQGT 234
DT G S+P F +E++ K K H HND LAVANSL A + G Q++ T
Sbjct: 171 PDTVGYSIPYKTEEFFRELIAKTPNGGKVVWSAHCHNDLGLAVANSLAALKGGARQVECT 230
Query: 235 INGYGERCGNANLISIIPALELKYGVEVVGKER---LRKLKELAHFVAELANMEIPRNQP 291
+NG GER GNA++ I+ AL++++ ++ G E ++ + V+ + + N+
Sbjct: 231 VNGLGERAGNASVEEIVMALKVRH--DLFGLETGIDTTQIVPSSKLVSTITGYPVQPNKA 288
Query: 292 YVGDSAFAHKGGVHVSAVLKNPRTYEHIDPELVG-NRRKVVVSELSGRSNLIYKAKELGI 350
VG +AF+H+ G+H VLK+ TYE + E VG ++ + +LSGR+ K +LGI
Sbjct: 289 IVGANAFSHESGIHQDGVLKHRETYEIMSAESVGWATNRLSLGKLSGRNAFKTKLADLGI 348
Query: 351 ELEERD--------IKRIVEEIKKLEFEGYHFEAAEASLELLIERLRGRYKPFFELERAR 402
ELE + K + ++ +++ E H L+ + + ++ +
Sbjct: 349 ELESEEALNAAFARFKELADKKREIFDEDLH--------ALVSDEMGSMNAESYKFISQK 400
Query: 403 VITEIFQGQPPISEANVVVRVNSRRVHTTAEGNGPVNALDLALRKALTKFYPELKEIKLV 462
+ TE G+ P A++V + +A G+GPV+A+ A+ L
Sbjct: 401 ISTE--TGEEP--RADIVFSIKGEEKRASATGSGPVDAIFKAIESVAQ------SGAALQ 450
Query: 463 DYKVRVLGSEKGTAAKVRVLVQTSDGKKTWGTVGASTNIIEASLNAIMESM 513
Y V + +GT ++ V+ + G + GA T+++ A+ A + ++
Sbjct: 451 IYSVNAV--TQGTESQGETSVRLARGNRVVNGQGADTDVLVATAKAYLSAL 499
>pir||C81895 probable 2-isopropylmalate synthase (EC 4.1.3.12) NMA1270
[imported] - Neisseria meningitidis (group A strain
Z2491) >gi|7379949|emb|CAB84524.1| (AL162755) putative
2-isopropylmalate synthase [Neisseria meningitidis
Z2491]
Length = 517
Score = 175 bits (439), Expect = 1e-42
Identities = 141/531 (26%), Positives = 250/531 (46%), Gaps = 50/531 (9%)
Query: 1 MLMKRRVELYDTTLRDGSQMEGISFSLEDKLKITEKLDEFGIHYIEGGWPGSNPKDIQYF 60
M RV ++DTTLRDG Q G + + E+K+++ +L++ G+ IE G+ ++P D F
Sbjct: 1 MTQANRVIIFDTTLRDGEQSPGAAMTKEEKIRVARQLEKLGVDIIEAGFAAASPGD---F 57
Query: 61 KAVRDLPLENAKIAAFGSTRRPRLRPEEDPNLNALVESEAPIATI--FGKSWDLHVTEAL 118
+AV + K +R E D + AP I F + +H+ L
Sbjct: 58 EAVNAIAKTITKSTVCSLSRAI----ERDIRQAGEAVAPAPKKRIHTFIATSPIHMEYKL 113
Query: 119 RTTLENNIQMIIDSIEYLRDHGMVVFYDAEHFFDGYRENPEYAMKTIKAAEEAGAERIVL 178
+ + I+ + +++ R++ V + E D R ++ + A EAGA I +
Sbjct: 114 KMKPKQVIEAAVKAVKIAREYTDDVEFSCE---DALRSEIDFLAEICGAVIEAGATTINI 170
Query: 179 ADTNGGSLP----SFIKEVVEKVKEEVKTPLGIHAHNDSELAVANSLIAFEAGVVQIQGT 234
DT G S+P F +E++ K K H HND LAVANSL A + G Q++ T
Sbjct: 171 PDTVGYSIPYKTEEFFRELIVKTPNGGKVVWSAHCHNDLGLAVANSLAALKGGARQVECT 230
Query: 235 INGYGERCGNANLISIIPALELKYGVEVVGKER---LRKLKELAHFVAELANMEIPRNQP 291
+NG GER GNA++ I+ AL++++ ++ G E ++ + V+ + + N+
Sbjct: 231 VNGLGERAGNASVEEIVMALKVRH--DLFGLETGIDTTQIVPSSKLVSTITGYPVQPNKA 288
Query: 292 YVGDSAFAHKGGVHVSAVLKNPRTYEHIDPELVG-NRRKVVVSELSGRSNLIYKAKELGI 350
VG +AF+H+ G+H VLK+ TYE + E VG ++ + +LSGR+ K +LGI
Sbjct: 289 IVGANAFSHESGIHQDGVLKHRETYEIMSAESVGWATNRLSLGKLSGRNAFKTKLADLGI 348
Query: 351 ELEERD--------IKRIVEEIKKLEFEGYHFEAAEASLELLIERLRGRYKPFFELERAR 402
ELE + K + ++ +++ E H L+ + + ++ +
Sbjct: 349 ELESEEALNAAFARFKELADKKREIFDEDLH--------ALVSDEMGSMNAESYKFISQK 400
Query: 403 VITEIFQGQPPISEANVVVRVNSRRVHTTAEGNGPVNALDLALRKALTKFYPELKEIKLV 462
+ TE G+ P A++V + +A G+GPV+A+ A+ L
Sbjct: 401 ISTE--TGEEP--RADIVFSIKGEEKRASATGSGPVDAIFKAIESVAQ------SGAALQ 450
Query: 463 DYKVRVLGSEKGTAAKVRVLVQTSDGKKTWGTVGASTNIIEASLNAIMESM 513
Y V + +GT ++ V+ + G + GA T+++ A+ A + ++
Sbjct: 451 IYSVNAV--TQGTESQGETSVRLARGNRVVNGQGADTDVLVATAKAYLSAL 499
>gb|AAG31927.1|AF200469_1 (AF200469) 2-isopropylmalate synthase [Buchnera aphidicola]
Length = 502
Score = 173 bits (433), Expect = 6e-42
Identities = 146/525 (27%), Positives = 266/525 (49%), Gaps = 41/525 (7%)
Query: 16 DGSQMEGISFSLEDKLKITEKLDEFGIHYIEGGWPGSNPKDIQYFKAVRDLP--LENAKI 73
DG Q S S+++KL+I L++ G+ +E G+P S+P D FK+V+ + ++++++
Sbjct: 1 DGEQALQASLSVKEKLQIALCLEKSGVDIMEVGFPISSPGD---FKSVQTISQKIKHSRV 57
Query: 74 AAFGSTRRPRLRPEEDPNLNALVESEAPIATIFGKSWDLHVTEALRTTLENNIQMIIDSI 133
+ + + D A+ S++ IF + LH+ L+ I M I S+
Sbjct: 58 CSLARC----IEKDIDVAGEAMSASDSFRIHIFLATSTLHMESKLKKNFNEIIDMAIFSV 113
Query: 134 EYLRDHGMVVFYDAEHFFDGYRENPEYAMKTIKAAEEAGAERIVLADTNGGSLPS----F 189
+ + V + E D R + + ++ G + I + DT G ++P+
Sbjct: 114 KRALRYTDDVEFSCE---DASRTTIDNLCRIVEKLISCGVKTINIPDTVGYTIPNELSFI 170
Query: 190 IKEVVEKVKEEVKTPLGIHAHNDSELAVANSLIAFEAGVVQIQGTINGYGERCGNANLIS 249
IK + E+V K+ + +H HND +AV NS+ A +AG QI+GTING GER GN L
Sbjct: 171 IKNLFERVPNIHKSTISVHCHNDLGMAVGNSISAIQAGARQIEGTINGIGERAGNTALEE 230
Query: 250 IIPALELKYGVEVVGKERLRKLKEL---AHFVAELANMEIPRNQPYVGDSAFAHKGGVHV 306
+I A++++ +++G KE+ + V+ + NM IP N+ VG +AF+H G+H
Sbjct: 231 VIMAIKVR--EDILGLSTNINHKEIYRTSQIVSSICNMPIPSNKAIVGSNAFSHSSGIHQ 288
Query: 307 SAVLKNPRTYEHIDPELVGNRR-KVVVSELSGRSNLIYKAKELGIELEERDIKRIVEEIK 365
VLKN YE IDP +G ++ K+ ++ SGR+ + Y E+G + + +I + +
Sbjct: 289 DGVLKNRENYEIIDPISIGLKKVKLNLTSRSGRAAVKYYMNEMGYKENDYNIDELYTDFL 348
Query: 366 KL-EFEGYHFEAAEASLELLIERLRGRYKPFFELERARVITEIFQGQPPISEANVVVRVN 424
KL + +G F+ +L + + +F L+ + +S A+V + +
Sbjct: 349 KLADKKGQVFDYDLEALAFI--NKQQDESEYFSLK----FFSVQSISNNLSTASVTL-LC 401
Query: 425 SRRVHTTAE--GNGPVNALDLALRKALTKFYPELKEIKLVDYKVRVLGSEKGTAAKVRVL 482
++++T A NGPV+A+ AL + +T F L++ +L+ G K +V +L
Sbjct: 402 GKKIYTEASTTSNGPVDAIYQALNR-ITHFPIVLQKFQLI-----AKGKGKDALGQVDIL 455
Query: 483 VQTSDGKKTWGTVGASTNIIEASLNAIMESM-EYWLMKEREKDEK 526
V+ K+ + VG +T+I+E+S A++ + W+ K+ K+ K
Sbjct: 456 VEYK--KRKFHGVGLATDIMESSAKAMVNVLNNIWIAKQVNKNLK 498
>dbj|BAB08874.1| (AB026660) 2-isopropylmalate synthase-like; homocitrate
synthase-like [Arabidopsis thaliana]
Length = 506
Score = 172 bits (432), Expect = 7e-42
Identities = 121/409 (29%), Positives = 203/409 (49%), Gaps = 31/409 (7%)
Query: 7 VELYDTTLRDGSQMEGISFSLEDKLKITEKLDEFGIHYIEGGWPGSNPKDIQYFKAV--- 63
V ++DTTLRDG Q G S + KL+I +L + + +E G+PGS+ ++++ K +
Sbjct: 85 VRVFDTTLRDGEQSPGGSLTPPQKLEIARQLAKLRVDIMEVGFPGSSEEELETIKTIAKT 144
Query: 64 --RDLPLENAKIAAFGSTRRPRLRPEEDPNLNALVESEAPIATIFGKSWDLHVTEALRTT 121
++ E + + R + R E AL ++ P +F + D+H+ L+ T
Sbjct: 145 VGNEVDEETGYVPVICAIARCKHRDIE-ATWEALKYAKRPRILVFTSTSDIHMKYKLKKT 203
Query: 122 LENNIQMIIDSIEYLRDHGMVVFYDAEHFF-DGYRENPEYAMKTIKAAEEAGAERIVLAD 180
E I+M + SI + + G F D + DG R + ++ K + A +AG + + D
Sbjct: 204 QEEVIEMAVSSIRFAKSLG---FNDIQFGCEDGGRSDKDFLCKILGEAIKAGVTVVTIGD 260
Query: 181 TNGGSLPSFIKEVVEKVKEEVKTP------LGIHAHNDSELAVANSLIAFEAGVVQIQGT 234
T G ++P E+V +K TP + +H HND LA ANS+ AG Q++ T
Sbjct: 261 TVGINMPHEYGELVTYLK--ANTPGIDDVVVAVHCHNDLGLATANSIAGIRAGARQVEVT 318
Query: 235 INGYGERCGNANLISIIPALELKYGVEVVG---KERLRKLKELAHFVAELANMEIPRNQP 291
ING GER GNA+L ++ AL+ + + G K R++ + V E + + ++P
Sbjct: 319 INGIGERSGNASLEEVVMALKCRGAYVINGVYTKIDTRQIMATSKMVQEYTGLYVQAHKP 378
Query: 292 YVGDSAFAHKGGVHVSAVLKNPRTYEHIDPELVG----NRRKVVVSELSGRSNLIYKAKE 347
VG + F H+ G+H +LKN TYE + PE +G +V+ +LSGR + + KE
Sbjct: 379 IVGANCFVHESGIHQDGILKNRSTYEILSPEDIGIVKSQNSGLVLGKLSGRHAVKDRLKE 438
Query: 348 LGIELEERDIKRIVEEIKKLEFEGYHFEAAE------ASLELLIERLRG 390
LG EL++ + + + L A+ +S E+ +E+L G
Sbjct: 439 LGYELDDEKLNAVFSLFRDLTKNKKRITDADLKALVTSSDEISLEKLNG 487
>gb|AAG31395.1| (AF197454) 2-isopropylmaltate synthase [Buchnera aphidicola]
Length = 503
Score = 172 bits (432), Expect = 7e-42
Identities = 146/523 (27%), Positives = 262/523 (49%), Gaps = 37/523 (7%)
Query: 16 DGSQMEGISFSLEDKLKITEKLDEFGIHYIEGGWPGSNPKDIQYFKAVRDLP--LENAKI 73
DG Q S S+++KL+I L++ G+ +E G+P S+P D FK+V+ + ++N+++
Sbjct: 1 DGEQALQASLSVKEKLQIALCLEKSGVDIMEVGFPISSPGD---FKSVQTISQKIKNSRV 57
Query: 74 AAFGSTRRPRLRPEEDPNLNALVESEAPIATIFGKSWDLHVTEALRTTLENNIQMIIDSI 133
+ + + D A+ S + IF + LH+ LR I M I S+
Sbjct: 58 CSLARC----IEKDIDVAGEAMSASNSFRIHIFLATSTLHMESKLRKNFNEIIDMAIFSV 113
Query: 134 EYLRDHGMVVFYDAEHFFDGYRENPEYAMKTIKAAEEAGAERIVLADTNGGSLPS----F 189
+ + + + E D R + + ++ G + I + DT G ++P+
Sbjct: 114 KRALRYTDDIEFSCE---DASRTTIDNLCRIVEKLISCGVKTINIPDTVGYTIPNELSFI 170
Query: 190 IKEVVEKVKEEVKTPLGIHAHNDSELAVANSLIAFEAGVVQIQGTINGYGERCGNANLIS 249
IK + EKV K+ + +H H+D +AV NS+ A +AG QI+GTING GER GN L
Sbjct: 171 IKNLFEKVPNIHKSTISVHCHDDLGMAVGNSISAIQAGARQIEGTINGIGERAGNTALEE 230
Query: 250 IIPALELKYGVEVVGKE-RLRKLKELAHFVAELANMEIPRNQPYVGDSAFAHKGGVHVSA 308
+I A++++ + V +++ + V+ + NM IP N+ VG +AFAH G+H
Sbjct: 231 VIMAIKVREDILGVSTNINHKEIYRTSQIVSSICNMPIPSNKAIVGSNAFAHSSGIHQDG 290
Query: 309 VLKNPRTYEHIDPELVGNRR-KVVVSELSGRSNLIYKAKELGIELEERDIKRIVEEIKKL 367
VLKN YE IDP +G ++ K+ ++ SGR+ + + E+G + + +I + + KL
Sbjct: 291 VLKNRENYEIIDPISIGLKKVKLNLTSRSGRAAVKHYMNEMGYKENDYNIDELYTDFLKL 350
Query: 368 -EFEGYHFEAAEASLELLIERLRGRYKPFFELERARVITEIFQGQPPISEANVVVRVNSR 426
+ +G F+ +L + + +F L+ + +S A+V + + +
Sbjct: 351 ADKKGQVFDYDLEALAFI--NKQQDESEYFSLK----FFSVQSISNNLSTASVTL-LCGK 403
Query: 427 RVHTTAE--GNGPVNALDLALRKALTKFYPELKEIKLVDYKVRVLGSEKGTAAKVRVLVQ 484
+++T A NGPV+A+ AL + +T F L++ +LV G K +V +LV+
Sbjct: 404 KIYTEASTTSNGPVDAIYQALNR-ITHFPIVLQKFQLV-----AKGKGKDALGQVDILVE 457
Query: 485 TSDGKKTWGTVGASTNIIEASLNAIMESM-EYWLMKEREKDEK 526
K+ + VG +T+I+E+S A++ + W K+ K+ K
Sbjct: 458 YK--KRKFHGVGLATDIMESSAKAMVNVLNNIWKAKQVNKNLK 498
>gb|AAG31377.1| (AF197448) 2-isopropylmaltate synthase [Buchnera aphidicola]
Length = 502
Score = 171 bits (430), Expect = 1e-41
Identities = 146/527 (27%), Positives = 261/527 (48%), Gaps = 45/527 (8%)
Query: 16 DGSQMEGISFSLEDKLKITEKLDEFGIHYIEGGWPGSNPKDIQYFKAVRDLP--LENAKI 73
DG Q S S+++KL+I L++ G+ +E G+P S+P D FK+V+ + ++N++I
Sbjct: 1 DGEQALQASLSVKEKLQIALCLEKAGVDIMEVGFPISSPGD---FKSVQTISQNIKNSRI 57
Query: 74 AAFGSTRRPRLRPEEDPNLNALVESEAPIATIFGKSWDLHVTEALRTTLENNIQMIIDSI 133
+ + + D A+ + +F + LH+ LR + I M I S+
Sbjct: 58 CSLARC----IEKDIDTAGEAMSHCDFFRIHVFLATSTLHMESKLRKNFDEIIDMAIFSV 113
Query: 134 EYLRDHGMVVFYDAEHFFDGYRENPEYAMKTIKAAEEAGAERIVLADTNGGSLPS----F 189
+ + V + E D R + + ++ G + I + DT G ++P+
Sbjct: 114 KRALRYTDDVEFSCE---DASRTTMDNLCRIVEKLISCGVKTINIPDTVGYTIPNELSLI 170
Query: 190 IKEVVEKVKEEVKTPLGIHAHNDSELAVANSLIAFEAGVVQIQGTINGYGERCGNANLIS 249
IK + E+V K+ + +H HND +AV NS+ A +AG QI+GTING GER GN L
Sbjct: 171 IKNLFERVPNIHKSTISVHCHNDLGMAVGNSISAIQAGARQIEGTINGIGERAGNTALEE 230
Query: 250 IIPALELKYGVEVVGKERLRKLKEL---AHFVAELANMEIPRNQPYVGDSAFAHKGGVHV 306
+I A++++ +++G KE+ + ++ + NM IP N+ VG +AF+H G+H
Sbjct: 231 VIMAIKVR--EDILGLSTNINHKEIYRTSQVISRICNMPIPSNKAIVGSNAFSHSSGIHQ 288
Query: 307 SAVLKNPRTYEHIDPELVGNRR-KVVVSELSGRSNLIYKAKELGIELEERDIKRI-VEEI 364
VLKN YE +DP +G ++ K+ ++ SGR+ + Y E+G + + +I + V+ +
Sbjct: 289 DGVLKNRENYEIMDPSSIGLKKVKLNLTSRSGRAAVKYYMNEMGYKDSDYNIDELYVDFL 348
Query: 365 KKLEFEGYHFE---AAEASLELLIERLRGRYKPFFELERARVITEIFQGQPPISEANVVV 421
K + +G F+ A A + + L FF ++ +S A+V +
Sbjct: 349 KLADKKGQVFDYDLEALAFINKKQDELEHFCLKFFSVQSI---------SNNLSTASVTL 399
Query: 422 RVNSR-RVHTTAEGNGPVNALDLALRKALTKFYPELKEIKLVDYKVRVLGSEKGTAAKVR 480
+ ++ NGPV A+ AL + +T F L++ +L+ G K +V
Sbjct: 400 LCGDKIYTESSTTSNGPVXAIYQALNR-ITHFPIILQKFQLI-----AKGQGKDALGQVD 453
Query: 481 VLVQTSDGKKTWGTVGASTNIIEASLNAIMESM-EYWLMKEREKDEK 526
+LV+ K+ + VG +T+IIE+S A++ + W +K+ K+ K
Sbjct: 454 ILVKYK--KRQFHGVGLATDIIESSAQAMINVLNNIWKVKQVNKNLK 498
>gb|AAG31398.1| (AF197455) 2-isopropylmaltate synthase [Buchnera aphidicola]
Length = 502
Score = 171 bits (428), Expect = 2e-41
Identities = 144/525 (27%), Positives = 267/525 (50%), Gaps = 41/525 (7%)
Query: 16 DGSQMEGISFSLEDKLKITEKLDEFGIHYIEGGWPGSNPKDIQYFKAVRDLP--LENAKI 73
DG Q S S+++KL+I L++ G+ +E G+P S+P D FK+V+ + ++N++I
Sbjct: 1 DGEQALQASLSVKEKLQIALCLEKAGVDIMEVGFPISSPGD---FKSVQTISQNIKNSRI 57
Query: 74 AAFGSTRRPRLRPEEDPNLNALVESEAPIATIFGKSWDLHVTEALRTTLENNIQMIIDSI 133
+ + + D A+ S + IF + LH+ LR I M I ++
Sbjct: 58 CSLARC----IEKDIDAAGEAMSISNSFRIHIFLATSTLHMESKLRKNFNEIIDMAIFAV 113
Query: 134 EYLRDHGMVVFYDAEHFFDGYRENPEYAMKTIKAAEEAGAERIVLADTNGGSLPSFIKEV 193
+ + + + E D R + + ++ +G + I + DT G ++P+ + +
Sbjct: 114 KRALRYTDDIEFSCE---DASRTTIDNLCRIVEKLISSGVKTINIPDTVGYTIPNELSNI 170
Query: 194 VEKVKEEV----KTPLGIHAHNDSELAVANSLIAFEAGVVQIQGTINGYGERCGNANLIS 249
++ + E V K+ + +H HND +AV NS+ A +AG QI+GTING GER GN L
Sbjct: 171 IKSLFERVPNIHKSIISVHCHNDLGMAVGNSISAIQAGARQIEGTINGIGERAGNTALEE 230
Query: 250 IIPALELKYGVEVVGKERLRKLKEL---AHFVAELANMEIPRNQPYVGDSAFAHKGGVHV 306
II A++++ +++G KE+ + V+ + N+ IP N+ VG +AF+H G+H
Sbjct: 231 IIMAIKVR--EDILGLSTNINHKEIYRTSQIVSRICNVPIPSNKAIVGSNAFSHSSGIHQ 288
Query: 307 SAVLKNPRTYEHIDPELVGNRR-KVVVSELSGRSNLIYKAKELGIELEERDIKRIVEEIK 365
VLKN YE +DP +G ++ ++ ++ SGR+ + Y KE+G + + +I + +
Sbjct: 289 DGVLKNRENYEIMDPSSIGLKKVRLNLTSRSGRAAVKYYMKEMGYKENDYNIDELYTDFL 348
Query: 366 KL-EFEGYHFEAAEASLELLIERLRGRYKPFFELERARVITEIFQGQPPISEANVVVRVN 424
KL + +G F+ +L + + +F L+ + +S A+V + +
Sbjct: 349 KLADKKGQVFDYDLEALAFI--NKQQDESEYFSLK----FFSVQSISNNLSTASVTL-LC 401
Query: 425 SRRVHTTAE--GNGPVNALDLALRKALTKFYPELKEIKLVDYKVRVLGSEKGTAAKVRVL 482
++++T A NGPV+A+ AL + +T F L++ +L+ G K +V +L
Sbjct: 402 GKKIYTEASTTSNGPVDAIYQALNR-ITHFPIILQKFQLI-----AKGKGKDALGQVDIL 455
Query: 483 VQTSDGKKTWGTVGASTNIIEASLNAIMESM-EYWLMKEREKDEK 526
V+ K+ + VG +T+I+E+S A++ + W K+ K+ K
Sbjct: 456 VEYK--KRKFHGVGLATDIMESSAKAMVNVLNNIWKAKQVNKNLK 498
>gb|AAG31401.1| (AF197456) 2-isopropylmaltate synthase [Buchnera aphidicola]
Length = 502
Score = 169 bits (425), Expect = 5e-41
Identities = 142/510 (27%), Positives = 257/510 (49%), Gaps = 44/510 (8%)
Query: 16 DGSQMEGISFSLEDKLKITEKLDEFGIHYIEGGWPGSNPKDIQYFKAVRDLP--LENAKI 73
DG Q S S+++KL+I L++ G+ +E G+P S+P D FK+V+ + ++N++I
Sbjct: 1 DGEQALQASLSVKEKLQIALCLEKIGVDIMEIGFPISSPGD---FKSVQIISKNIKNSRI 57
Query: 74 AAFGSTRRPRLRPEEDPNLNALVESEAPIATIFGKSWDLHVTEALRTTLENNIQMIIDSI 133
+ + + D A+ S + IF + LH+ L+ I M I ++
Sbjct: 58 CSLARC----VEKDIDAAGEAMSASNSFRIHIFLATSTLHMEYKLKKNFHEIIDMAIFAV 113
Query: 134 EYLRDHGMVVFYDAEHFFDGYRENPEYAMKTIKAAEEAGAERIVLADTNGGSLPS----F 189
+ + + + E D R + + ++ G + I + DT G ++P+
Sbjct: 114 KRALRYTDDIEFSCE---DASRTTIDNLCRIVEKLIYHGVKTINIPDTVGYTVPNELSYI 170
Query: 190 IKEVVEKVKEEVKTPLGIHAHNDSELAVANSLIAFEAGVVQIQGTINGYGERCGNANLIS 249
IK ++E+V K+ + +H H+D +AV NS+ A +AG QI+GTING GER GN L
Sbjct: 171 IKNLLERVPNIHKSIISVHCHDDLGMAVGNSISAIQAGARQIEGTINGIGERAGNTALEE 230
Query: 250 IIPALELKYGVEVVGKERLRKLKELAH---FVAELANMEIPRNQPYVGDSAFAHKGGVHV 306
+I A++++ +++G KE+ H ++ + NM IP N+ VG +AF+H G+H
Sbjct: 231 VIMAIKVR--EDILGVSTNINYKEIYHTSKIISRICNMPIPPNKAIVGSNAFSHSSGIHQ 288
Query: 307 SAVLKNPRTYEHIDPELVGNRR-KVVVSELSGRSNLIYKAKELGIELEERDIKRIVEEIK 365
VLKN + YE IDP +G ++ K+ ++ SGR+ + Y E+G + + +I + +
Sbjct: 289 DGVLKNRKNYEIIDPSSIGFKKLKLNLTSRSGRAAVKYYMSEMGYKDTDYNIDELYADFL 348
Query: 366 KL-EFEGYHFEAAEASLELLI---ERLRGRYKPFFELERARVITEIFQGQPPISEANVVV 421
KL + +G F+ SL + E L FF ++ I G +S A++ +
Sbjct: 349 KLADKKGQVFDYDLESLAFISKHPEELEHFCLKFFSVQ------SISNG---LSTASIKL 399
Query: 422 RVNSR-RVHTTAEGNGPVNALDLALRKALTKFYPELKEIKLVDYKVRVLGSEKGTAAKVR 480
+ + ++ NGPV+A+ AL K +T F L++ +L+ G K +V
Sbjct: 400 LCGQKLYIESSTTSNGPVDAIYQALNK-ITNFPIILQKFQLI-----AKGKGKDALGQVN 453
Query: 481 VLVQTSDGKKTWGTVGASTNIIEASLNAIM 510
+L++ K+ + +G +T+ IE+S A++
Sbjct: 454 ILIEYK--KRKFHGIGLATDFIESSAKAMV 481
>gb|AAG31404.1| (AF197457) 2-isopropylmaltate synthase [Buchnera aphidicola]
Length = 506
Score = 169 bits (425), Expect = 5e-41
Identities = 142/522 (27%), Positives = 261/522 (49%), Gaps = 35/522 (6%)
Query: 16 DGSQMEGISFSLEDKLKITEKLDEFGIHYIEGGWPGSNPKDIQYFKAVRDLP--LENAKI 73
DG Q S S+++KL+I L++ GI +E G+P S+P D FK+V+ + ++N++I
Sbjct: 1 DGEQALQASLSVKEKLQIALSLEKCGIDILEIGFPVSSPGD---FKSVQTISKNIKNSRI 57
Query: 74 AAFGSTRRPRLRPEEDPNLNALVESEAPIATIFGKSWDLHVTEALRTTLENNIQMIIDSI 133
+ + + D A+ S++ IF + LH+ L+ I M + S+
Sbjct: 58 CSLARC----IEKDIDAAGEAMSSSDSFRIHIFLATSTLHMESKLKKNFNEIIDMAVFSV 113
Query: 134 EYLRDHGMVVFYDAEHFFDGYRENPEYAMKTIKAAEEAGAERIVLADTNGGSLPS----F 189
+ + + + E D R + + ++ ++G + I + DT G ++P+
Sbjct: 114 KKALRYTDDIEFSCE---DATRTTMDNLCRIVETLIKSGVKTINIPDTVGYTVPNELSCI 170
Query: 190 IKEVVEKVKEEVKTPLGIHAHNDSELAVANSLIAFEAGVVQIQGTINGYGERCGNANLIS 249
IK + E+V K+ + +H H+D +AV NS+ A +AG QI+GTING GER GN L
Sbjct: 171 IKNLFERVPNIHKSIISVHCHDDLGMAVGNSISAIQAGARQIEGTINGIGERAGNTALEE 230
Query: 250 IIPALELKYGVEVVGKE-RLRKLKELAHFVAELANMEIPRNQPYVGDSAFAHKGGVHVSA 308
II A++++ + V +++ + V+++ NM IP N+ VG +AFAH G+H
Sbjct: 231 IIMAIKVREDILSVSTNINYKEIYRTSKIVSQICNMPIPSNKAIVGSNAFAHSSGIHQDG 290
Query: 309 VLKNPRTYEHIDPELVGNRR-KVVVSELSGRSNLIYKAKELGIELEERDIKRI-VEEIKK 366
VLKN + YE ++P +G + K+ ++ SGR+ + + E+G + +I + + +K
Sbjct: 291 VLKNRKNYEIMEPSSIGLKEVKLNLTSRSGRAAVKHYMDEMGYNNSDYNIDELYIAFLKL 350
Query: 367 LEFEGYHFEAAEASLELLIERLRGRYKPFFELERARVITEIFQGQPPISEANVVVRVNSR 426
+ +G F+ +L I + + ++ +F L+ + +S A+V + +
Sbjct: 351 ADKKGQVFDYDLEAL-AFINKQQDEWE-YFSLK----FFSVQSISNSLSTASVKLLCGKK 404
Query: 427 R-VHTTAEGNGPVNALDLALRKALTKFYPELKEIKLVDYKVRVLGSEKGTAAKVRVLVQT 485
++ NGPV+A+ AL + +P I L +++ G K +V +LV+
Sbjct: 405 TYTESSTTSNGPVDAIYQALNRIAC--FP----IILQKFQLVAKGKGKDALGQVDILVEH 458
Query: 486 SDGKKTWGTVGASTNIIEASLNAIMESM-EYWLMKEREKDEK 526
K+ + VG +T+IIEAS A++ + W K+ K K
Sbjct: 459 K--KRKFHGVGLATDIIEASAQAMINVLNNIWKAKQVNKKLK 498
>gb|AAG31383.1| (AF197450) 2-isopropylmaltate synthase [Buchnera aphidicola]
Length = 502
Score = 168 bits (421), Expect = 1e-40
Identities = 139/522 (26%), Positives = 256/522 (48%), Gaps = 35/522 (6%)
Query: 16 DGSQMEGISFSLEDKLKITEKLDEFGIHYIEGGWPGSNPKDIQYFKAVRDLP--LENAKI 73
DG Q S S+++KL+I L++ G+ IE G+P S+P D FK+V+ + ++N+KI
Sbjct: 1 DGEQSLQASLSVKEKLQIALCLEKAGVDIIEVGFPISSPGD---FKSVQTISQKIKNSKI 57
Query: 74 AAFGSTRRPRLRPEEDPNLNALVESEAPIATIFGKSWDLHVTEALRTTLENNIQMIIDSI 133
+ + + D A+ + IF + LH+ LR I+M I S+
Sbjct: 58 CSLARC----IEKDIDTAAEAMSVCNSFRIHIFLATSTLHIESKLRKNFNEIIEMAIFSV 113
Query: 134 EYLRDHGMVVFYDAEHFFDGYRENPEYAMKTIKAAEEAGAERIVLADTNGGSLPSFIKEV 193
+ + + + E D R + + ++ G + I + DT G ++P+ + V
Sbjct: 114 KRALRYTDDIEFSCE---DASRTTMDNLCRIVEKLIYCGVKTINIPDTVGYTVPNELSGV 170
Query: 194 VEKVKEEV----KTPLGIHAHNDSELAVANSLIAFEAGVVQIQGTINGYGERCGNANLIS 249
++ + E V K+ + +H HND +AV NS+ A +AG QI+GTING GER GN L
Sbjct: 171 IKNLFERVPNIHKSIISVHCHNDLGMAVGNSISAIQAGARQIEGTINGIGERAGNTALEE 230
Query: 250 IIPALELKYGVEVVGKE-RLRKLKELAHFVAELANMEIPRNQPYVGDSAFAHKGGVHVSA 308
+I A++++ + V +++ + + ++ + N+ +P N+ VG +AF+H G+H
Sbjct: 231 VIMAIKVREDILGVSTNINHKEIYQTSQIISRICNIPVPSNKAIVGSNAFSHSSGIHQDG 290
Query: 309 VLKNPRTYEHIDPELVGNRR-KVVVSELSGRSNLIYKAKELGIELEERDIKRIVEEIKKL 367
VLKN YE +DP +G ++ K+ ++ SGR+ + Y +G + + +I + KL
Sbjct: 291 VLKNRENYEIMDPNSIGLKKVKLNLTSRSGRAAVKYYMNYMGYKDSDYNIDELYFNFLKL 350
Query: 368 -EFEGYHFEAAEASLELLIERLRGRYKPFFELERARVITEIFQGQPPISEANVVVRVNSR 426
+ +G F+ +L + + +F L+ + +S A+V + +
Sbjct: 351 ADKKGQVFDYDLEALAFM--NKKHDESEYFSLQ----FFSVQSISNNLSTASVKLLCGKK 404
Query: 427 R-VHTTAEGNGPVNALDLALRKALTKFYPELKEIKLVDYKVRVLGSEKGTAAKVRVLVQT 485
++ NGPV A+ AL K +T+F I L +++ G K +V++LV+
Sbjct: 405 TYTESSTTSNGPVEAIYQALNK-ITQF-----PIVLQTFQLIAKGKGKDALGEVKILVEY 458
Query: 486 SDGKKTWGTVGASTNIIEASLNAIMESM-EYWLMKEREKDEK 526
K+ + +G + NIIE++ A++ + W K+ K K
Sbjct: 459 K--KRQFHGLGLAANIIESAAQAMINVLNNIWQAKQVNKKLK 498
>gb|AAG31389.1| (AF197452) 2-isopropylmaltate synthase [Buchnera aphidicola]
Length = 503
Score = 168 bits (421), Expect = 1e-40
Identities = 149/526 (28%), Positives = 261/526 (49%), Gaps = 43/526 (8%)
Query: 16 DGSQMEGISFSLEDKLKITEKLDEFGIHYIEGGWPGSNPKDIQYFKAVRDLP--LENAKI 73
DG Q S S+E+KL I L++ G+ +E G+P S+P D FK+V+ + ++N++I
Sbjct: 1 DGEQALQASLSVEEKLXIALCLEKTGVDIMEVGFPISSPGD---FKSVQTISKKIKNSQI 57
Query: 74 AAFGSTRRPRLRPEEDPNLNALVESEAPIATIFGKSWDLHVTEALRTTLENNIQMIIDSI 133
+ + + D A+ + IF + LH+ LR + I M I S+
Sbjct: 58 CSLARC----IEKDIDIAGEAMSVCDFFRIHIFLATSRLHMKSKLRKNFDEIIDMAIFSV 113
Query: 134 EYLRDHGMVVFYDAEHFFDGYRENPEYAMKTIKAAEEAGAERIVLADTNGGSLPS----F 189
+ + V + E D R + + ++ +G + I + DT G S+P+
Sbjct: 114 KRALRYTDDVQFSCE---DASRTTIDNLCRIVEKLINSGVKTINIPDTVGYSIPNELSFI 170
Query: 190 IKEVVEKVKEEVKTPLGIHAHNDSELAVANSLIAFEAGVVQIQGTINGYGERCGNANLIS 249
IK + ++V K + +H H+D +AV NS+ A +AG QI+GTING GER GN L
Sbjct: 171 IKNLFQRVPNIDKAVISVHCHDDLGMAVGNSISAIQAGARQIEGTINGIGERAGNTALEE 230
Query: 250 IIPALELK-YGVEVVGKERLRKLKELAHFVAELANMEIPRNQPYVGDSAFAHKGGVHVSA 308
+I A++++ + V +++ + ++ + NM IP N+ VG +AF+H G+H
Sbjct: 231 VIMAIKVREKNLGVYTNINHKEIYRTSQMISRICNMPIPSNKAIVGSNAFSHSSGIHQDG 290
Query: 309 VLKNPRTYEHIDPELVGNRR-KVVVSELSGRSNLIYKAKELGIELEERDIKRIVEEIKKL 367
VLKN YE IDP +G + ++ ++ SGR+ + Y E+G + + +I + + KL
Sbjct: 291 VLKNRENYEIIDPVSIGLKNVQLNLTSRSGRAAVKYYMNEMGYKDSDYNIDELYSDFLKL 350
Query: 368 -EFEGYHFEAAEASLELLI---ERLRGRYKPFFELERARVITEIFQGQPPISEANVVVRV 423
+ +G F+ SL + + L FF ++ I G +S A+V + +
Sbjct: 351 ADKKGQVFDYDLESLAFISKQQDELEYFCLKFFSVQ------SISNG---LSTASVKL-L 400
Query: 424 NSRRVHT--TAEGNGPVNALDLALRKALTKFYPELKEIKLVDYKVRVLGSEKGTAAKVRV 481
++V+T + NGPV+A+ AL + +T F L++ +L+ G K +V +
Sbjct: 401 CGKKVYTESSTTSNGPVDAIYQALNR-ITHFPITLQKFQLI-----AKGKGKDALGQVDI 454
Query: 482 LVQTSDGKKTWGTVGASTNIIEASLNAIMESM-EYWLMKEREKDEK 526
LV+ K+ + VG +T+IIE+S A++ + W K+ K K
Sbjct: 455 LVEYK--KRKFHGVGLATDIIESSAKAMINVLNNIWKAKQVNKKLK 498
>gb|AAG31386.1| (AF197451) 2-isopropylmaltate synthase [Buchnera aphidicola]
Length = 491
Score = 166 bits (417), Expect = 4e-40
Identities = 142/515 (27%), Positives = 263/515 (50%), Gaps = 43/515 (8%)
Query: 27 LEDKLKITEKLDEFGIHYIEGGWPGSNPKDIQYFKAVRDLP--LENAKIAAFGSTRRPRL 84
+++KL+I L++ G+ +E G+P S+P D FK+V+ + ++N++I + L
Sbjct: 1 VKEKLQIALSLEKAGVDIMEVGFPISSPGD---FKSVQTISKNIKNSRICSLARC----L 53
Query: 85 RPEEDPNLNALVESEAPIATIFGKSWDLHVTEALRTTLENNIQMIIDSIEYLRDHGMVVF 144
+ D A+ ++ IF + LH+ LR + M + S++ + V
Sbjct: 54 EKDIDAAGEAMSVCDSFRIHIFLATSTLHMESKLRKNFNEIVDMAVFSVKKALRYTDDVE 113
Query: 145 YDAEHFFDGYRENPEYAMKTIKAAEEAGAERIVLADTNGGSLPSFIKEVVEKVKEEV--- 201
+ E D R + + ++ ++G + I + DT G S+P+ + +++ + E V
Sbjct: 114 FSCE---DASRTTIDNLCRIVEKLIKSGVKTINIPDTVGYSIPNELTCIIQNLFERVPNI 170
Query: 202 -KTPLGIHAHNDSELAVANSLIAFEAGVVQIQGTINGYGERCGNANLISIIPALELKYGV 260
K+ + +H H+D +AV NS+ A +AG QI+GTING GER GN L +I A++++ +
Sbjct: 171 HKSIISVHCHDDLGMAVGNSISAIQAGARQIEGTINGIGERAGNTALEEVIMAIKVRKDI 230
Query: 261 EVVGKE-RLRKLKELAHFVAELANMEIPRNQPYVGDSAFAHKGGVHVSAVLKNPRTYEHI 319
V +++ + ++ + NM IP N+ VG +AF+H G+H VLKN YE +
Sbjct: 231 LGVSTNINHKEIYRTSQIISRICNMPIPSNKAIVGSNAFSHSSGIHQDGVLKNRENYEIM 290
Query: 320 DPELVGNRR-KVVVSELSGRSNLIYKAKELGIELEERDIKRIVEEIKKL-EFEGYHFEAA 377
DP+ +G ++ K+ ++ SGR+ + Y E+G + + +I + + KL + +G F+
Sbjct: 291 DPKSIGLKKVKLNLTSRSGRAAVRYYMNEMGYKDSDYNIDELYADFLKLADKKGQVFDYD 350
Query: 378 EASLELLIERLRGRYKPFFELERARVITEIFQGQP---PISEANVVVRVNSRRVHT--TA 432
SL + K ELE R+ + F Q +S A+V + + ++++T +
Sbjct: 351 LESLAFI-------NKQQDELEYFRL--QFFSVQSISNNLSTASVKL-LCGKKIYTESST 400
Query: 433 EGNGPVNALDLALRKALTKFYPELKEIKLVDYKVRVLGSEKGTAAKVRVLVQTSDGKKTW 492
NGPV+A+ AL + +T F I L +++ G K +V +LV+ K+ +
Sbjct: 401 TSNGPVDAVYQALNR-ITHF-----PIILQKFQLMAKGKGKDALGQVDILVEYK--KRKF 452
Query: 493 GTVGASTNIIEASLNAIMESM-EYWLMKEREKDEK 526
VG +T+IIE+S A++ + W K+ K+ K
Sbjct: 453 HGVGLATDIIESSAQAMVNVLNNIWKAKQVNKNLK 487
>gb|AAG31392.1| (AF197453) 2-isopropylmaltate synthase [Buchnera aphidicola]
Length = 502
Score = 166 bits (417), Expect = 4e-40
Identities = 143/525 (27%), Positives = 263/525 (49%), Gaps = 43/525 (8%)
Query: 16 DGSQMEGISFSLEDKLKITEKLDEFGIHYIEGGWPGSNPKDIQYFKAVRDLP--LENAKI 73
DG Q S S+++KL+I L++ + +E G+P S+P D FK+V+ + ++N++I
Sbjct: 1 DGEQALQASLSVKEKLQIALCLEKAKVDIMEVGFPISSPGD---FKSVQTISKNIKNSRI 57
Query: 74 AAFGSTRRPRLRPEEDPNLNALVESEAPIATIFGKSWDLHVTEALRTTLENNIQMIIDSI 133
+ + + D A+ ++ +F + LH+ LR I M + S+
Sbjct: 58 CSLARC----IEKDIDAAGEAMSVCDSFRIHLFLATSILHMESKLRKNFNEIIDMAVFSV 113
Query: 134 EYLRDHGMVVFYDAEHFFDGYRENPEYAMKTIKAAEEAGAERIVLADTNGGSLPS----F 189
+ + + + E D R + + ++ G + I + DT G ++P+
Sbjct: 114 KKALRYTDDIEFSCE---DASRSTIDNLCRIVEVLINTGVKTINIPDTVGYAVPNEFSFI 170
Query: 190 IKEVVEKVKEEVKTPLGIHAHNDSELAVANSLIAFEAGVVQIQGTINGYGERCGNANLIS 249
IK + E+V K+ + +H H+D +AV NS+ A +AG QI+GTING GER GN L
Sbjct: 171 IKSLFERVPNIHKSVISVHCHDDLGMAVGNSISAIQAGARQIEGTINGIGERAGNTALEE 230
Query: 250 IIPALELKYGVEVVGKE-RLRKLKELAHFVAELANMEIPRNQPYVGDSAFAHKGGVHVSA 308
II A++++ + V +++ + V+ + NM IP N+ VG +AF+H G+H
Sbjct: 231 IIMAIKVRENLLGVSTNINHKEIYRTSQIVSRICNMPIPSNKSIVGSNAFSHSSGIHQDG 290
Query: 309 VLKNPRTYEHIDPELVGNRR-KVVVSELSGRSNLIYKAKELGIELEERDIKRI-VEEIKK 366
VLKN YE +DP +G ++ K+ ++ SGR+ + Y ++G + + +I + V+ +K
Sbjct: 291 VLKNRENYEIMDPISIGVKKVKLNLTSRSGRAAVKYYMNQMGYKDSDYNIDELYVDFLKL 350
Query: 367 LEFEGYHFEAAEASLELL---IERLRGRYKPFFELERARVITEIFQGQPPISEANVVVRV 423
+ +G F+ SL + + L Y FF ++ +S A+V + +
Sbjct: 351 ADKKGQVFDYDLESLAFINKQQDELEHFYLKFFSVQSI---------SNSLSTASVKL-L 400
Query: 424 NSRRVHT--TAEGNGPVNALDLALRKALTKFYPELKEIKLVDYKVRVLGSEKGTAAKVRV 481
+ +HT + NGPV+A+ AL K +T F L++ +L+ G K +V +
Sbjct: 401 CGKDLHTESSTTSNGPVDAIYQALNK-ITHFPIVLQKFQLI-----AKGKGKDALGQVDI 454
Query: 482 LVQTSDGKKTWGTVGASTNIIEASLNAIMESMEYWLMKEREKDEK 526
+V+ K+ + VG +T+IIE+S A++ + + K ++ +EK
Sbjct: 455 IVEYK--KRKFHGVGLATDIIESSAKAMINVLNN-IWKAKQVNEK 496
>gb|AAF13763.1|AF117351_20 (AF117351) homocitrate synthase [Zymomonas mobilis]
Length = 386
Score = 166 bits (415), Expect = 7e-40
Identities = 117/365 (32%), Positives = 180/365 (49%), Gaps = 33/365 (9%)
Query: 11 DTTLRDGSQMEGISFSLEDKLKITEKLDEFGIHYIEGGWPGSNPKDIQYFKAV------- 63
DTTLRDG Q G++F+L +KL I + LD+ G+ IE G P +I+ + +
Sbjct: 13 DTTLRDGEQAPGVAFTLSEKLHIAKALDKAGVDEIEAGIPAMGASEIEAIRQIVQQSQTA 72
Query: 64 RDLPLENAKIAAFGSTRRPRLRPEEDPNLNALVESEAPIATIFGKSWDLHVTEALRTTLE 123
R +P KI+ E L S +P + K DL + L +
Sbjct: 73 RVIPWCRMKISDVDKAL------ETGAKTVHLSISSSPFQ-MAAKFPDLSAADILGLCQK 125
Query: 124 NNIQMIIDSIEYLRDHGMVVFYDAEHFFDGYRENPEYAMKTIKAAEEAGAERIVLADTNG 183
I Y +D G+ V AE D R + + EEAGA RI ADT G
Sbjct: 126 --------VISYAKDRGLEVSVGAE---DASRAEISFLTDLLGVIEEAGAFRIRFADTLG 174
Query: 184 GSLPSFIKEVVEKVKEEVKTPLGIHAHNDSELAVANSLIAFEAGVVQIQGTINGYGERCG 243
P E++ ++ + + H H+D LA ANSL A +AG T+ G GER G
Sbjct: 175 ILDPFATYEIISQLHQISPLDIEFHGHDDLGLATANSLAAIKAGAKGASVTVLGLGERAG 234
Query: 244 NANLISIIPALELKYGVEVVGKE---RLRKLKELAHFVAELANMEIPRNQPYVGDSAFAH 300
NA+L ++ A + GKE R KL LA +VA+ A IP ++ VG++ F H
Sbjct: 235 NASLEQVVIAAS-----HIAGKETRIRPEKLYNLAQYVAQAAGRTIPPDKAIVGEAVFQH 289
Query: 301 KGGVHVSAVLKNPRTYEHIDPELVGNRRKVVVSELSGRSNLIYKAKELGIELEERDIKRI 360
+ G+HV+ +L+NP +YE ++PE +G +R++V+ + SGR+ + + LGI+ +E I+ +
Sbjct: 290 ESGIHVAGLLRNPASYEALNPEKLGRQREIVLGKHSGRAAIRHALSLLGIKAQEDMIQNL 349
Query: 361 VEEIK 365
+ +K
Sbjct: 350 LAAVK 354
>sp|O87198|HOSC_THETH HOMOCITRATE SYNTHASE >gi|11268243|pir||T51170 homocitrate synthase
(EC 4.1.3.21) [validated] - Thermus aquaticus
>gi|3724367|dbj|BAA33785.1| (AB018379) homocitrate
synthase [Thermus thermophilus]
Length = 376
Score = 165 bits (414), Expect = 1e-39
Identities = 119/376 (31%), Positives = 188/376 (49%), Gaps = 27/376 (7%)
Query: 5 RRVELYDTTLRDGSQMEGISFSLEDKLKITEKLDEFGIHYIEGGWPGSNPKDIQYFKAVR 64
R ++ D+TLR+G Q E +FS +DK++I + LDEFGI YIE P ++P+ + + +
Sbjct: 2 REWKIIDSTLREGEQFEKANFSTQDKVEIAKALDEFGIEYIEVTTPVASPQSRKDAEVLA 61
Query: 65 DLPLENAKIAAFGSTRRPRLRPEEDPNLNALVESEAPIATIFGKSWDLHVTEALRTTLEN 124
L L+ AK+ R + + + I +FG S + LR
Sbjct: 62 SLGLK-AKVVTHIQCRLDAAKVAVETGVQG-------IDLLFGTS------KYLRAPHGR 107
Query: 125 NIQMIIDS----IEYLRDHG--MVVFYDAEHFFDGYRENPEYAMKTIKAAEEAGAERIVL 178
+I II+ I Y+R+ + V + AE F + E + + A +R+ L
Sbjct: 108 DIPRIIEEAKEVIAYIREAAPHVEVRFSAEDTF----RSEEQDLLAVYEAVAPYVDRVGL 163
Query: 179 ADTNGGSLPSFIKEVVEKVKEEV--KTPLGIHAHNDSELAVANSLIAFEAGVVQIQGTIN 236
ADT G + P + +V +V+ V + + H HND+ A+AN+ A EAG + TI
Sbjct: 164 ADTVGVATPRQVYALVREVRRVVGPRVDIEFHGHNDTGCAIANAYEAIEAGATHVDTTIL 223
Query: 237 GYGERCGNANLISIIPALELKYGVEVVGKERLRKLKELAHFVAELANMEIPRNQPYVGDS 296
G GER G L + + V K +L L EL VA + +EIP N G++
Sbjct: 224 GIGERNGITPLGGFLARMYTLQPEYVRRKYKLEMLPELDRMVARMVGVEIPFNNYITGET 283
Query: 297 AFAHKGGVHVSAVLKNPRTYEHIDPELVGNRRKVVV-SELSGRSNLIYKAKELGIELEER 355
AF+HK G+H+ A+ NP YE PE+ G +RK+++ S L+GR + +A+ELG+ E
Sbjct: 284 AFSHKAGMHLKAIYINPEAYEPYPPEVFGVKRKLIIASRLTGRHAIKARAEELGLHYGEE 343
Query: 356 DIKRIVEEIKKLEFEG 371
++ R+ + IK L G
Sbjct: 344 ELHRVTQHIKALADRG 359
>pir||C81270 2-isopropylmalate synthase (EC 4.1.3.12) Cj1719c [imported] -
Campylobacter jejuni (strain NCTC 11168)
>gi|6969134|emb|CAB73705.1| (AL139079) 2-isopropylmalate
synthase [Campylobacter jejuni]
Length = 511
Score = 165 bits (414), Expect = 1e-39
Identities = 153/522 (29%), Positives = 240/522 (45%), Gaps = 46/522 (8%)
Query: 6 RVELYDTTLRDGSQMEGISFSLEDKLKITEKLDEFGIHYIEGGWPGSNPKDIQYFKAVRD 65
++ ++DTTLRDG Q G S + KL+I L+ G+ IE G+P S+ D FKAV+
Sbjct: 5 KIIIFDTTLRDGEQALGSSLGINQKLQIALALENLGVDVIEAGFPVSSQGD---FKAVQK 61
Query: 66 LP--LENAKIAAFGSTRRPRLRPEEDPNLNAL-VESEAPIATIFGKSWDLHVTEALRTTL 122
+ ++N+ I A L + D AL V I T S LH+ + L+
Sbjct: 62 IASKVKNSTICALSRA----LDKDIDMAYEALKVAKHFRIHTFIATS-TLHMQDKLKKDF 116
Query: 123 ENNIQMIIDSIEYLRDHGMVVFYDAEHFFDGYRENPEYAMKTIKAAEEAGAERIVLADTN 182
+ + M +I R + V + E D R + ++ A +AGA+ I + DT
Sbjct: 117 DEILSMAKRAIIRARSYTDDVEFSCE---DAGRTPIDNLCFMVENAIKAGAKTINIPDTV 173
Query: 183 GGSLPS----FIKEVVEKVKEEVKTPLGIHAHNDSELAVANSLIAFEAGVVQIQGTINGY 238
G +LPS IK + KV K + +H HND +A NSL A G QI+ TING
Sbjct: 174 GYTLPSEFANIIKILFNKVPNIDKAIISVHCHNDLGMATGNSLSAILQGARQIECTINGL 233
Query: 239 GERCGNANLISIIPALELK--YGVEVVGKERLRKLKELAHFVAELANMEIPRNQPYVGDS 296
GER GN L ++ A++ + Y + + + + V+ + N IP ++ VG +
Sbjct: 234 GERAGNCALEEVVMAIKTRKDYLKGFYTDIKCENIFKTSKLVSAITNESIPSHKAIVGSN 293
Query: 297 AFAHKGGVHVSAVLKNPRTYEHIDPELVG-NRRKVVVSELSGRSNLIYKAKELGIELEER 355
AF+H G+H VLKN +TYE I P +G + +++++ SGR+ + + LG +
Sbjct: 294 AFSHSSGIHQDGVLKNRQTYEIISPSAIGIHENRMLMTARSGRAMIKTCLENLGYDENTY 353
Query: 356 DIKRIVEEI-----KKLEFEGYHFEAAEASLELLIERLRGRYKPFFELERARVITEIFQG 410
++ + E KK + Y EA L+ + F LE+ VI+
Sbjct: 354 NLDDVYERFLRLADKKGQVYDYDLEA------LMFLSYESEEENEFVLEKLSVIS----- 402
Query: 411 QPPISEANVVVRVNSRRVHTTAEGNGPVNALDLALRKALTKFYPELKEIKLVDYKVRVLG 470
I A V +R+ GNGPV A+ + + +T P LK Y +
Sbjct: 403 -GNIPTACVCMRIKEELKTEACTGNGPVEAVFNCIAR-ITNLKPALKA-----YSINAKS 455
Query: 471 SEKGTAAKVRVLVQTSDGKKTWGTVGASTNIIEASLNAIMES 512
S +V V ++ G+K G G ST++IEAS A + +
Sbjct: 456 SGVDAQGQVDVDLEFK-GRKFHGK-GLSTDVIEASAQAFVSA 495
>dbj|BAB09819.1| (AB006708) 2-isopropylmalate synthase-like protein [Arabidopsis
thaliana]
Length = 503
Score = 163 bits (408), Expect = 5e-39
Identities = 116/383 (30%), Positives = 189/383 (49%), Gaps = 25/383 (6%)
Query: 4 KRRVELYDTTLRDGSQMEGISFSLEDKLKITEKLDEFGIHYIEGGWPGSNPKDIQYFKAV 63
K V + DTTLRDG Q G + + KL+I +L + + +E G+P S+ ++ + K +
Sbjct: 82 KNYVRVLDTTLRDGEQSPGAALTPPQKLEIARQLAKLRVDIMEVGFPVSSEEEFEAIKTI 141
Query: 64 -----RDLPLENAKIAAFGSTRRPRLRPEEDPNLNALVESEAPIATIFGKSWDLHVTEAL 118
++ E + R + R E AL ++ P +F + ++H+ L
Sbjct: 142 AKTVGNEVDEETGYVPVICGIARCKKRDIE-ATWEALKYAKRPRVMLFTSTSEIHMKYKL 200
Query: 119 RTTLENNIQMIIDSIEYLRDHGMV-VFYDAEHFFDGYRENPEYAMKTIKAAEEAGAERIV 177
+ T E I+M ++S++Y + G + + E DG R ++ K + + +AGA +
Sbjct: 201 KKTKEEVIEMAVNSVKYAKSLGFKDIQFGCE---DGGRTEKDFICKILGESIKAGATTVG 257
Query: 178 LADTNGGSLPSFIKEVVEKVKEEVKTP------LGIHAHNDSELAVANSLIAFEAGVVQI 231
ADT G ++P E+V V E TP IH HND +A AN++ AG Q+
Sbjct: 258 FADTVGINMPQEFGELVAYVIEN--TPGADDIVFAIHCHNDLGVATANTISGICAGARQV 315
Query: 232 QGTINGYGERCGNANLISIIPALELKYGVEVVG---KERLRKLKELAHFVAELANMEIPR 288
+ TING GER GNA L ++ AL+ + + G K R++ + V E M +
Sbjct: 316 EVTINGIGERSGNAPLEEVVMALKCRGESLMDGVYTKIDSRQIMATSKMVQEHTGMYVQP 375
Query: 289 NQPYVGDSAFAHKGGVHVSAVLKNPRTYEHIDPELVG----NRRKVVVSELSGRSNLIYK 344
++P VGD+ F H+ G+H +LKN TYE + PE VG +V+ +LSGR + +
Sbjct: 376 HKPIVGDNCFVHESGIHQDGILKNRSTYEILSPEDVGIVKSENSGIVLGKLSGRHAVKDR 435
Query: 345 AKELGIELEERDIKRIVEEIKKL 367
KELG E+ + I ++L
Sbjct: 436 LKELGYEISDEKFNDIFSRYREL 458
>emb|CAB91069.1| (AJ239033) homocitrate sythase 1 [Anabaena variabilis]
Length = 381
Score = 160 bits (401), Expect = 3e-38
Identities = 110/365 (30%), Positives = 183/365 (50%), Gaps = 22/365 (6%)
Query: 6 RVELYDTTLRDGSQMEGISFSLEDKLKITEKLDEFGIHYIEGGWPGSNPKDIQYFKAVRD 65
+V + DTTLRDG Q G+ F+LE+K+ I + LD G+ +E G P ++++ A+ +
Sbjct: 3 KVLINDTTLRDGEQAAGVVFTLEEKVAIAKFLDTIGVPELEVGIPAMGEEEMRAICAISN 62
Query: 66 LPLENAKIAAFGSTRRPRLRPEEDPNLN----ALVESEAPIATIFGKSWDLHVTEALRTT 121
L L+ A + A+ ++ + A+ S IA F W +
Sbjct: 63 LGLK-ANLLAWNRAVISDIKASVACGMERVHIAIPVSGIQIAAKFHGQWRV--------- 112
Query: 122 LENNIQMIIDSIEYLRDHGMVVFYDAEHFFDGYRENPEYAMKTIKAAEEAGAERIVLADT 181
++Q + D I + D G+ V E D R + + + A+E GA R DT
Sbjct: 113 ---SLQRLKDCISFAVDQGLWVAVGGE---DSSRADENFLLDVALYAQEWGASRFRFCDT 166
Query: 182 NGGSLPSFIKEVVEKVKEEVKTPLGIHAHNDSELAVANSLIAFEAGVVQIQGTINGYGER 241
G P V+ + + P+ +H HND +A AN+L +AG + T+ G GER
Sbjct: 167 VGVLDPFTTYGKVKLLVSALTIPVEVHTHNDFGMATANALAGIKAGAASVNTTVIGLGER 226
Query: 242 CGNANLISIIPALELKYGVEVVGKERLRKLKELAHFVAELANMEIPRNQPYVGDSAFAHK 301
GNA L ++ A++ YGV++ G + R L EL+ VA + +P + VG++ FAH+
Sbjct: 227 AGNAALEEVVMAIKRIYGVDM-GIDTPRLL-ELSQLVAAASGANVPPWKAIVGENTFAHE 284
Query: 302 GGVHVSAVLKNPRTYEHIDPELVGNRRKVVVSELSGRSNLIYKAKELGIELEERDIKRIV 361
G+H VL+NP TYE PE VG R++VV + SGR ++ ++ GI L + + ++
Sbjct: 285 SGIHAHGVLQNPDTYEPFAPEEVGWERRLVVGKHSGRHSVSNLLEQHGIFLNPEETQSVL 344
Query: 362 EEIKK 366
+ +++
Sbjct: 345 DAVRQ 349
>gb|AAG31926.1|AF200468_1 (AF200468) 2-isopropylmalate synthase [Buchnera aphidicola]
Length = 437
Score = 157 bits (392), Expect = 4e-37
Identities = 129/447 (28%), Positives = 225/447 (49%), Gaps = 33/447 (7%)
Query: 29 DKLKITEKLDEFGIHYIEGGWPGSNPKDIQYFKAVRDLP--LENAKIAAFGSTRRPRLRP 86
+KL+I L++ G+ +E G+P S+P D FK+V+ + ++N++I + L
Sbjct: 1 EKLQIALSLEKIGVDIMEVGFPISSPGD---FKSVQTISKNIKNSRICSLARC----LEK 53
Query: 87 EEDPNLNALVESEAPIATIFGKSWDLHVTEALRTTLENNIQMIIDSIEYLRDHGMVVFYD 146
+ D A+ + IF + LH+ LR I+M I S++ + V +
Sbjct: 54 DIDAAGEAMSVCDNFRIHIFLATSTLHIESKLRKNFNEIIEMAIFSVKKALRYTNDVEFS 113
Query: 147 AEHFFDGYRENPEYAMKTIKAAEEAGAERIVLADTNGGSLPS----FIKEVVEKVKEEVK 202
E D R N + + ++ ++G + I + DT G S P IK + E+V K
Sbjct: 114 CE---DASRTNIDNLCRIVEKLIKSGVKTINIPDTVGYSTPDELTFIIKNLFERVPNIHK 170
Query: 203 TPLGIHAHNDSELAVANSLIAFEAGVVQIQGTINGYGERCGNANLISIIPALELKYGVEV 262
+ + +H H+D +AV NS+ A +AG QI+GTING GER GN L +I A++++ +
Sbjct: 171 SIISVHCHDDLGMAVGNSIAAIQAGARQIEGTINGIGERAGNTALEEVIMAIKVRKNILG 230
Query: 263 VGKE-RLRKLKELAHFVAELANMEIPRNQPYVGDSAFAHKGGVHVSAVLKNPRTYEHIDP 321
V +++ + ++ + NM IP N+ VG +AF+H G+H VLKN YE +DP
Sbjct: 231 VSTNINHKEIYRTSQMISRICNMPIPSNKAIVGSNAFSHSSGIHQDGVLKNRENYEIMDP 290
Query: 322 ELVGNRR-KVVVSELSGRSNLIYKAKELGIELEERDIKRIVEEIKKL-EFEGYHFEAAEA 379
+G ++ K+ ++ SGR+ + Y E+G + + +I + + KL + +G F+
Sbjct: 291 RSIGLKKVKLNLTSRSGRAAVKYYMSEMGYKDSDYNIDELYTDFLKLADKKGQVFDYDLE 350
Query: 380 SLELLIERLRGRYKPFFELERARVITEIFQGQP---PISEANV-VVRVNSRRVHTTAEGN 435
SL + K ELE R+ + F Q +S A+V ++ N ++ N
Sbjct: 351 SLAFI-------NKQQDELEYFRL--QFFSVQSISNNLSTASVKLLCGNKTYTESSTTSN 401
Query: 436 GPVNALDLALRKALTKFYPELKEIKLV 462
GPV+A+ AL + +T F L++ +L+
Sbjct: 402 GPVDAIYQALNR-ITHFPIILQKFQLI 427
>sp|Q12726|HOSM_YARLI HOMOCITRATE SYNTHASE, MITOCHONDRIAL PRECURSOR
>gi|1246864|emb|CAA88928.1| (Z49114) homocitrate
synthase (acetyl-coenzyme A:2-Ketoglutarate
C-acetyltransferase) [Yarrowia lipolytica]
Length = 446
Score = 156 bits (391), Expect = 5e-37
Identities = 105/363 (28%), Positives = 180/363 (48%), Gaps = 13/363 (3%)
Query: 6 RVELYDTTLRDGSQMEGISFSLEDKLKITEKLDEFGIHYIEGGWPGSNPKDIQYFKAVRD 65
+ +L ++TLR+G Q F E K++I + LD+FG+ YIE P ++ + +A+
Sbjct: 47 KFQLIESTLREGEQFASAFFDTETKIEIAKALDDFGVDYIELTSPAASEQSRSDCEAICK 106
Query: 66 LPLENAKIAAFGSTRRPRLRPEEDPNLNALVESEAPIATIFGKSWDLHVTEALRTTLENN 125
L L+ AKI +R D A+ + + G S L + +
Sbjct: 107 LGLK-AKILT-------HIRCHMDDARLAVSTGVDGVDVVIGTSQFLRQYSHGKD-MNYI 157
Query: 126 IQMIIDSIEYLRDHGMVVFYDAEHFFDGYRENPEYAMKTIKAAEEAGAERIVLADTNGGS 185
Q ++ IE+++ HG+ + + +E D +R + + + ++ G R+ +ADT G +
Sbjct: 158 AQSAVEVIEFVKSHGIEIRFSSE---DSFRSDLVDLLNIYRTVDKIGVNRVGIADTVGCA 214
Query: 186 LPSFIKEVVEKVKEEVKTPLGIHAHNDSELAVANSLIAFEAGVVQIQGTINGYGERCGNA 245
P + E+V +K V + H HND+ A+AN+ A EAG I ++ G GER G
Sbjct: 215 NPRQVYELVRTLKSVVSCDIECHFHNDTGCAIANAYTALEAGANLIDVSVLGIGERNGIT 274
Query: 246 NLISIIPALELKYGVEVVGKERLRKLKELAHFVAELANMEIPRNQPYVGDSAFAHKGGVH 305
+L ++ + V+ K +L KL++L + VA+ + IP N P G AF HK G+H
Sbjct: 275 SLGGLMARMIAADRDYVLSKYKLHKLRDLENLVADAVQVNIPFNNPITGFCAFTHKAGIH 334
Query: 306 VSAVLKNPRTYEHIDPELVGNRRKV-VVSELSGRSNLIYKAKELGIELEERDIKRIVEEI 364
A+L NP TYE ++P G R + + L+G + + + +L + L + K + +I
Sbjct: 335 AKAILANPSTYEILNPADFGLTRYIHFANRLTGWNAIKSRVDQLNLHLTDAQCKDVTAKI 394
Query: 365 KKL 367
KKL
Sbjct: 395 KKL 397
>emb|CAB91068.1| (AJ239032) homocitrate synthase 2 [Anabaena variabilis]
Length = 379
Score = 156 bits (390), Expect = 6e-37
Identities = 106/341 (31%), Positives = 166/341 (48%), Gaps = 30/341 (8%)
Query: 6 RVELYDTTLRDGSQMEGISFSLEDKLKITEKLDEFGIHYIEGGWPGSNPKDIQYFKAVRD 65
+V + DTTLRDG Q G++FS+E+K+ I + LD G+ IE G P + + +
Sbjct: 3 KVLINDTTLRDGEQAAGVAFSVEEKIAIAKFLDAIGVDEIEVGIPAMGKAEQEAIANIVK 62
Query: 66 LPLENAKIAAFGSTRRPRLRPEEDPNLN----ALVESEAPIATIFGKSWDLHVTEALRTT 121
L L +A + + ++ L ++ S IA F W +
Sbjct: 63 LNL-SANLLGWNRAVISDIQASIACGLQRVHISIPVSAIQIAAKFHGQWQV--------- 112
Query: 122 LENNIQMIIDSIEYLRDHGMVVFYDAEHFFDGYRENPEYAMKTIKAAEEAGAERIVLADT 181
+Q + DSI + D G+ V E D R + + + AA+E GA R DT
Sbjct: 113 ---VLQKLHDSISFAVDQGLFVSIGGE---DSSRAEESFLLDVVLAAQEWGALRFRFCDT 166
Query: 182 NGGSLPSFIKEVVEKVKEEVKTPLGIHAHNDSELAVANSLIAFEAGVVQIQGTINGYGER 241
G P ++++ + P+ +H HND LA AN+L +AG + + T+NG GER
Sbjct: 167 VGILDPFTTHAKIKQLVASLTIPVEMHTHNDFGLATANALAGIKAGALSVNTTVNGLGER 226
Query: 242 CGNANLISIIPALELKY----GVEVVGKERLRKLKELAHFVAELANMEIPRNQPYVGDSA 297
GNA L ++ AL+ Y G++ R+L E++ V + +P + VG++
Sbjct: 227 AGNAALEEVVMALKHLYHHDLGIDT------RRLLEISQLVVSASGHPVPPWKAIVGENT 280
Query: 298 FAHKGGVHVSAVLKNPRTYEHIDPELVGNRRKVVVSELSGR 338
FAH+ G+H VL+NP+TYE PE VG R++VV + SGR
Sbjct: 281 FAHESGIHAHGVLQNPQTYEPFAPEEVGRERRLVVGKHSGR 321
>pir||T39279 probable homocitrate synthase (EC 4.1.3.21), mitochondrial isozyme
precursor - fission yeast (Schizosaccharomyces pombe)
>gi|5531464|emb|CAB50965.1| (AL096851) probable
homocitrate synthase, mitochondrial isozyme precursor(ec
4.1.3.21) [Schizosaccharomyces pombe]
Length = 418
Score = 155 bits (387), Expect = 1e-36
Identities = 109/364 (29%), Positives = 182/364 (49%), Gaps = 21/364 (5%)
Query: 9 LYDTTLRDGSQMEGISFSLEDKLKITEKLDEFGIHYIEGGWPGSNPKDIQYFKAVRDLPL 68
+ ++TLR+G Q F E K++I + LD FG+ YIE P ++ + Q +A+ L L
Sbjct: 37 IIESTLREGEQFANAFFDTEKKIQIAKALDNFGVDYIELTSPVASEQSRQDCEAICKLGL 96
Query: 69 ENAKIAAFGSTRRPRLRPEEDPNLNALVESEAPIATIFGKSWDLHVTEALRTTLENNIQM 128
+ KI +R D A+ + + G S L + + ++
Sbjct: 97 K-CKILT-------HIRCHMDDARVAVETGVDGVDVVIGTSQYLR-----KYSHGKDMTY 143
Query: 129 IIDS----IEYLRDHGMVVFYDAEHFFDGYRENPEYAMKTIKAAEEAGAERIVLADTNGG 184
IIDS I +++ G+ V + +E D +R + + KA ++ G R+ +ADT G
Sbjct: 144 IIDSATEVINFVKSKGIEVRFSSE---DSFRSDLVDLLSLYKAVDKIGVNRVGIADTVGC 200
Query: 185 SLPSFIKEVVEKVKEEVKTPLGIHAHNDSELAVANSLIAFEAGVVQIQGTINGYGERCGN 244
+ P + +++ ++ V + H HND+ +A+AN+ A EAG I +I G GER G
Sbjct: 201 ATPRQVYDLIRTLRGVVSCDIECHFHNDTGMAIANAYCALEAGATHIDTSILGIGERNGI 260
Query: 245 ANLISIIPALELKYGVEVVGKERLRKLKELAHFVAELANMEIPRNQPYVGDSAFAHKGGV 304
L +++ + + + K +L +L+EL + VA+ ++IP N G AF HK G+
Sbjct: 261 TPLGALLARMYVTDREYITHKYKLNQLRELENLVADAVEVQIPFNNYITGMCAFTHKAGI 320
Query: 305 HVSAVLKNPRTYEHIDPELVGNRRKV-VVSELSGRSNLIYKAKELGIELEERDIKRIVEE 363
H A+L NP TYE + PE G R V V S L+G + + +A++L + L + K +
Sbjct: 321 HAKAILANPSTYEILKPEDFGMSRYVHVGSRLTGWNAIKSRAEQLNLHLTDAQAKELTVR 380
Query: 364 IKKL 367
IKKL
Sbjct: 381 IKKL 384
>gi|6320071 homocitrate synthase, highly homologous to YDL182W; Lys21p
[Saccharomyces cerevisiae]
>gi|2492788|sp|Q12122|HOSM_YEAST HOMOCITRATE SYNTHASE,
MITOCHONDRIAL PRECURSOR >gi|2131288|pir||S67674
homocitrate synthase homolog YDL131w - yeast
(Saccharomyces cerevisiae) >gi|1419231|emb|CAA65629.1|
(X96876) putative ORF [Saccharomyces cerevisiae]
>gi|1431199|emb|CAA98700.1| (Z74179) ORF YDL131w
[Saccharomyces cerevisiae]
Length = 440
Score = 153 bits (384), Expect = 3e-36
Identities = 103/364 (28%), Positives = 179/364 (48%), Gaps = 13/364 (3%)
Query: 5 RRVELYDTTLRDGSQMEGISFSLEDKLKITEKLDEFGIHYIEGGWPGSNPKDIQYFKAVR 64
+ +L D+TLR+G Q F E K++I LD+FG+ YIE P ++ + + +A+
Sbjct: 35 KNFQLIDSTLREGEQFANAFFDTEKKIEIARALDDFGVDYIELTSPVASEQSRKDCEAIC 94
Query: 65 DLPLENAKIAAFGSTRRPRLRPEEDPNLNALVESEAPIATIFGKSWDLHVTEALRTTLEN 124
L L+ AKI +R D A+ + + G S L + +
Sbjct: 95 KLGLK-AKILT-------HIRCHMDDARVAVETGVDGVDVVIGTSKFLRQYSHGKD-MNY 145
Query: 125 NIQMIIDSIEYLRDHGMVVFYDAEHFFDGYRENPEYAMKTIKAAEEAGAERIVLADTNGG 184
+ ++ IE+++ G+ + + +E D +R + + K ++ G R+ +ADT G
Sbjct: 146 IAKSAVEVIEFVKSKGIEIRFSSE---DSFRSDLVDLLNIYKTVDKIGVNRVGIADTVGC 202
Query: 185 SLPSFIKEVVEKVKEEVKTPLGIHAHNDSELAVANSLIAFEAGVVQIQGTINGYGERCGN 244
+ P + E++ +K V + H HND+ A+AN+ A E G I ++ G GER G
Sbjct: 203 ANPRQVYELIRTLKSVVSCDIECHFHNDTGCAIANAYTALEGGARLIDVSVLGIGERNGI 262
Query: 245 ANLISIIPALELKYGVEVVGKERLRKLKELAHFVAELANMEIPRNQPYVGDSAFAHKGGV 304
L ++ + + V K +L K++++ + VA+ + IP N P G AF HK G+
Sbjct: 263 TPLGGLMARMIVAAPDYVRSKYKLHKIRDIENLVADAVEVNIPFNNPITGFCAFTHKAGI 322
Query: 305 HVSAVLKNPRTYEHIDPELVGNRRKV-VVSELSGRSNLIYKAKELGIELEERDIKRIVEE 363
H A+L NP TYE +DP G +R + + L+G + + + +L + L + IK + +
Sbjct: 323 HAKAILANPSTYEILDPHDFGMKRYIHFANRLTGWNAIKSRVDQLNLNLTDDQIKEVTAK 382
Query: 364 IKKL 367
IKKL
Sbjct: 383 IKKL 386
>gb|AAG27075.1|AF105225_11 (AF105225) NifV [Acetobacter diazotrophicus]
Length = 378
Score = 153 bits (384), Expect = 3e-36
Identities = 111/360 (30%), Positives = 174/360 (47%), Gaps = 15/360 (4%)
Query: 6 RVELYDTTLRDGSQMEGISFSLEDKLKITEKLDEFGIHYIEGGWPGSNPKDIQYFKAVRD 65
R+ + DTTLRDG Q G++F+ +KL I LD G+ IE G P +I A+ D
Sbjct: 6 RLLISDTTLRDGEQAPGVAFTAWEKLAIAGALDAAGVDEIEAGVPAMGDAEIAMIAAIGD 65
Query: 66 LPLENAKIAAFGSTRRPRLRPEEDPNLNALVESEAPIATIFGKSWDLHVTEALRTTLENN 125
+E A++ + R + L ++ S ++T G+S A R + +
Sbjct: 66 -EVERARVIPWCRMRDEDVHAARRTGLGSVHLS---VSTSSGRS---RRNTACRASHAGH 118
Query: 126 IQMIIDSIEYLRDHGMVVFYDAEHFFDGYRENPEYAMKTIKAAEEAGAERIVLADTNGGS 185
++ RD+G+ V E D R +P Y + + EAGA R ADT G
Sbjct: 119 GARVVSRA---RDYGLAVSVGGE---DASRADPAYLVDLLGVIAEAGAFRFRFADTLGVM 172
Query: 186 LPSFIKEVVEKVKEEVKTPLGIHAHNDSELAVANSLIAFEAGVVQIQGTINGYGERCGNA 245
P + EV+ + + L H H+D LA AN+L A AG T+ G GER GNA
Sbjct: 173 DPFGVHEVMRYLCQSSPLQLEFHGHDDLGLATANTLAAVRAGAACASVTVLGLGERAGNA 232
Query: 246 NLISIIPALELKYGVEVVGKERLRKLKELAHFVAELANMEIPRNQPYVGDSAFAHKGGVH 305
L ++ + G K L L LA V+ A +IP ++ VGD+ F H+ G+H
Sbjct: 233 PLEEVVAGVYRLLGRPAGVK--LDSLPGLATLVSRAAVRDIPPDKAIVGDAVFRHESGIH 290
Query: 306 VSAVLKNPRTYEHIDPELVGNRRKVVVSELSGRSNLIYKAKELGIELEERDIKRIVEEIK 365
VS +L++ TYE +DP G +R++V+ + SGR+ + + LG++ +E I + ++
Sbjct: 291 VSGLLRDAATYEALDPVQFGRQREIVLGKHSGRAAVRHALAALGLDADETVIAATLAAVR 350
>gi|6320019 homocitrate synthase, highly homologous to YDL131W; Lys20p
[Saccharomyces cerevisiae]
>gi|1351812|sp|P48570|HOSC_YEAST HOMOCITRATE SYNTHASE,
CYTOSOLIC ISOZYME >gi|2131289|pir||S58735 homocitrate
synthase homolog YDL182w - yeast (Saccharomyces
cerevisiae) >gi|1004312|emb|CAA58264.1| (X83276) D1298
[Saccharomyces cerevisiae] >gi|1431295|emb|CAA98757.1|
(Z74230) ORF YDL182w [Saccharomyces cerevisiae]
Length = 428
Score = 153 bits (384), Expect = 3e-36
Identities = 103/361 (28%), Positives = 178/361 (48%), Gaps = 13/361 (3%)
Query: 8 ELYDTTLRDGSQMEGISFSLEDKLKITEKLDEFGIHYIEGGWPGSNPKDIQYFKAVRDLP 67
+L D+TLR+G Q F E K++I LD+FG+ YIE P ++ + + +A+ L
Sbjct: 24 QLIDSTLREGEQFANAFFDTEKKIEIARALDDFGVDYIELTSPVASEQSRKDCEAICKLG 83
Query: 68 LENAKIAAFGSTRRPRLRPEEDPNLNALVESEAPIATIFGKSWDLHVTEALRTTLENNIQ 127
L+ AKI +R D A+ + + G S L + + +
Sbjct: 84 LK-AKILT-------HIRCHMDDAKVAVETGVDGVDVVIGTSKFLRQYSHGKD-MNYIAK 134
Query: 128 MIIDSIEYLRDHGMVVFYDAEHFFDGYRENPEYAMKTIKAAEEAGAERIVLADTNGGSLP 187
++ IE+++ G+ + + +E D +R + + K ++ G R+ +ADT G + P
Sbjct: 135 SAVEVIEFVKSKGIEIRFSSE---DSFRSDLVDLLNIYKTVDKIGVNRVGIADTVGCANP 191
Query: 188 SFIKEVVEKVKEEVKTPLGIHAHNDSELAVANSLIAFEAGVVQIQGTINGYGERCGNANL 247
+ E++ +K V + H HND+ A+AN+ A E G I ++ G GER G L
Sbjct: 192 RQVYELIRTLKSVVSCDIECHFHNDTGCAIANAYTALEGGARLIDVSVLGIGERNGITPL 251
Query: 248 ISIIPALELKYGVEVVGKERLRKLKELAHFVAELANMEIPRNQPYVGDSAFAHKGGVHVS 307
++ + + V K +L K++++ + VA+ + IP N P G AF HK G+H
Sbjct: 252 GGLMARMIVAAPDYVKSKYKLHKIRDIENLVADAVEVNIPFNNPITGFCAFTHKAGIHAK 311
Query: 308 AVLKNPRTYEHIDPELVGNRRKV-VVSELSGRSNLIYKAKELGIELEERDIKRIVEEIKK 366
A+L NP TYE +DP G +R + + L+G + + + +L + L + IK + +IKK
Sbjct: 312 AILANPSTYEILDPHDFGMKRYIHFANRLTGWNAIKARVDQLNLNLTDDQIKEVTAKIKK 371
Query: 367 L 367
L
Sbjct: 372 L 372
>gb|AAF36732.1| (AC016662) putative 2-isopropylmalate synthase; 30920-27612
[Arabidopsis thaliana]
Length = 631
Score = 152 bits (380), Expect = 9e-36
Identities = 138/547 (25%), Positives = 251/547 (45%), Gaps = 59/547 (10%)
Query: 7 VELYDTTLRDGSQMEGISFSLEDKLKITEKLDEFGIHYIEGGWPGSNPKDIQYFKAVRD- 65
V ++DTTLRDG Q G + + ++KL I +L + G+ IE G+P ++ D + K + +
Sbjct: 87 VRIFDTTLRDGEQSPGATLTSKEKLDIARQLAKLGVDIIEAGFPAASKDDFEAVKTIAET 146
Query: 66 ---LPLENAKIAAFGSTRRPRLRPEEDPNLNALVESEAPIATIFGKSWDLHVTEALRTTL 122
EN + R + + + A+ ++ P F + D+H+ L+ +
Sbjct: 147 VGNTVDENGYVPVICGLSRCN-KKDIETAWEAVKYAKRPRIHTFIATSDIHLKYKLKKSK 205
Query: 123 ENNIQMIIDSIEYLRDHGMV-VFYDAEHFFDGYRENPEYAMKTIKAAEEAGAERIVLADT 181
E I++ + + + R G V + E D R EY + + +AGA + + DT
Sbjct: 206 EEVIEIARNMVRFARSLGCEDVEFSPE---DAGRSEREYLYEILGEVIKAGATTLNIPDT 262
Query: 182 NGGSLPSFIKEVVEKVKEEVKTP------LGIHAHNDSELAVANSLIAFEAGVVQIQGTI 235
G +LPS +++ +K TP + H ND L+ AN+L +G Q++ TI
Sbjct: 263 VGITLPSEFGQLIADIK--ANTPGIQNVIISTHCQNDLGLSTANTLSGAHSGARQVEVTI 320
Query: 236 NGYGERCGNANLISIIPALELKYGVEVVG----KERLRKLKELAHFVAELANMEIPRNQP 291
NG GER GNA+L ++ A++ + G V+G R + + V E M+ ++
Sbjct: 321 NGIGERAGNASLEEVVMAIKCR-GDHVLGGLFTGIDTRHIVMTSKMVEEYTGMQTQPHKA 379
Query: 292 YVGDSAFAHKGGVHVSAVLKNPRTYEHIDPELVGNRRK----VVVSELSGRSNLIYKAKE 347
VG +AFAH+ G+H +LK+ TYE + PE +G R +V+ +LSGR L + E
Sbjct: 380 IVGANAFAHESGIHQDGMLKHKGTYEIMSPEEIGLERSNDAGIVLGKLSGRHALKDRLNE 439
Query: 348 LGIELEERDIKRIVEEIKKLEFEGYHFEAAEASLELLIERLRGRYKPFFELERARVITEI 407
LG L++ + + K + + +A L L+ + + ++L + +I
Sbjct: 440 LGYVLDDGQLSNLFWRFKAVAEQ--KKRVTDADLIALVSDEVFQPEAVWKL----LDMQI 493
Query: 408 FQGQPPISEANVVVRVNSRRVHTTAE-GNGPVN----ALDLALRKALTKFYPELKEIKLV 462
G +S + V + + + H G GPV+ A+DL +++ T L+
Sbjct: 494 TCGTLGLSTSTVKLADSDGKEHVACSVGTGPVDAAYKAVDLIVKEPAT----------LL 543
Query: 463 DYKVRVLGSEKGTAAKVRVLVQTSDG------------KKTWGTVGASTNIIEASLNAIM 510
+Y + + A RVL++ + ++T+ GA +I+ +S+ A +
Sbjct: 544 EYSMNAVTEGIDAIATTRVLIRGDNNYSSTNAVTGESVERTFSGTGAGMDIVVSSVKAYV 603
Query: 511 ESMEYWL 517
++ L
Sbjct: 604 GALNKML 610
>sp|Q39891|LEU1_SOYBN PROBABLE 2-ISOPROPYLMALATE SYNTHASE (ALPHA-ISOPROPYLMALATE
SYNTHASE) (ALPHA-IPM SYNTHETASE) (LATE NODULIN 56)
(N-56) >gi|7447056|pir||T08590 2-isopropylmalate
synthase homolog - soybean >gi|532290|dbj|BAA07212.1|
(D38015) soybean late nodulin [Glycine max]
Length = 565
Score = 152 bits (379), Expect = 1e-35
Identities = 109/381 (28%), Positives = 187/381 (48%), Gaps = 28/381 (7%)
Query: 7 VELYDTTLRDGSQMEGISFSLEDKLKITEKLDEFGIHYIEGGWPGSNPKDIQYFKAVRDL 66
V + DTTLRDG Q G + + ++KL I +L + G+ I+ G+P ++ D K +
Sbjct: 33 VRILDTTLRDGEQSPGATMTAKEKLDIARQLVKLGVDIIQPGFPSASNSDFMAVKMIAQ- 91
Query: 67 PLENAK--------IAAFGSTRRPRLRPEEDPNLNALVESEAPIATIFGKSWDLHVTEAL 118
+ NA IA F + + A+ ++ P + +H+ L
Sbjct: 92 EVGNAVDDDGYVPVIAGFCRC----VEKDISTAWEAVKYAKRPRLCTSIATSPIHMEHKL 147
Query: 119 RTTLENNIQMIIDSIEYLRDHGMV-VFYDAEHFFDGYRENPEYAMKTIKAAEEAGAERIV 177
R + + IQ+ D +++ R G + + AE D R + E+ + + EAGA +
Sbjct: 148 RKSKDQVIQIARDMVKFARSLGCNDIQFGAE---DATRSDREFLYEILGVVIEAGATTVN 204
Query: 178 LADTNGGSLPSFIKEVVEKVKEEV----KTPLGIHAHNDSELAVANSLIAFEAGVVQIQG 233
+ADT G +P + +++ +K+ + H HND LA AN++ G Q++
Sbjct: 205 IADTVGIVMPLELGKLIVDIKDNTPGIANVIISTHCHNDLGLATANTIEGARTGARQLEV 264
Query: 234 TINGYGERCGNANLISIIPALELKYGVEVVG---KERLRKLKELAHFVAELANMEIPRNQ 290
TING GER GNA+L ++ AL K + G + R + E + V E + M + ++
Sbjct: 265 TINGIGERAGNASLEEVVMALASKGDHALNGLYTRINTRHILETSKMVEEYSGMHLQPHK 324
Query: 291 PYVGDSAFAHKGGVHVSAVLKNPRTYEHIDPELVGNRRK----VVVSELSGRSNLIYKAK 346
P VG +AF H G+H +LK+ TYE I PE +G++R +V+ +LSG L + +
Sbjct: 325 PLVGANAFVHASGIHQDGMLKHKGTYETISPEEIGHKRTTRIGIVLGKLSGSQALRKRLE 384
Query: 347 ELGIELEERDIKRIVEEIKKL 367
ELG +L+E ++ + + K +
Sbjct: 385 ELGYDLKEDEVDSVFWQFKAM 405
>sp|O94225|HOSM_PENCH HOMOCITRATE SYNTHASE, MITOCHONDRIAL PRECURSOR
>gi|4165570|emb|CAA11503.1| (AJ223630) homocitrate
synthase [Penicillium chrysogenum]
Length = 474
Score = 151 bits (377), Expect = 2e-35
Identities = 115/398 (28%), Positives = 191/398 (47%), Gaps = 19/398 (4%)
Query: 6 RVELYDTTLRDGSQMEGISFSLEDKLKITEKLDEFGIHYIEGGWPGSNPKDIQYFKAVRD 65
R ++ ++TLR+G Q F K++I + LD+FG+ YIE P ++ + +A+
Sbjct: 66 RFQIIESTLREGEQFANAFFDTAKKIEIAKALDDFGVDYIELTSPCASEQSRADCEAICK 125
Query: 66 LPLENAKIAAFGSTRRPRLRPEEDPNLNALVESEAPIATIFGKSWDL--HVTEALRTTLE 123
L L+ AKI +R D A+ + + G S L H T ++
Sbjct: 126 LGLK-AKILT-------HIRCHMDDARIAVETGVDGVDVVIGTSSYLREHSHGKDMTYIK 177
Query: 124 NNIQMIIDSIEYLRDHGMVVFYDAEHFFDGYRENPEYAMKTIKAAEEAGAERIVLADTNG 183
N I+ IE+++ G+ + + +E D +R + + A ++ G R+ +ADT G
Sbjct: 178 N---AAIEVIEFVKSKGIEIRFSSE---DSFRSDLVDLLSIYSAVDKVGVNRVGIADTVG 231
Query: 184 GSLPSFIKEVVEKVKEEVKTPLGIHAHNDSELAVANSLIAFEAGVVQIQGTINGYGERCG 243
+ P + E+V ++ V + H HND+ A+AN+ A EAG I ++ G GER G
Sbjct: 232 CASPRQVYELVRVLRGVVGCDIETHFHNDTGCAIANAFCALEAGATHIDTSVLGIGERNG 291
Query: 244 NANLISIIPALELKYGVEVVGKERLRKLKELAHFVAELANMEIPRNQPYVGDSAFAHKGG 303
L ++ + + V K +L KLKE+ VAE + IP N G AF HK G
Sbjct: 292 ITPLGGLMARMMVADREYVKSKYKLEKLKEIEDLVAEAVEVNIPFNNYITGFCAFTHKAG 351
Query: 304 VHVSAVLKNPRTYEHIDPELVGNRRKV-VVSELSGRSNLIYKAKELGIELEERDIKRIVE 362
+H A+L NP TYE I+P G R V S L+G + + +A++L +E+ + K
Sbjct: 352 IHAKAILNNPSTYEIINPADFGMSRYVHFASRLTGWNAIKSRAQQLKLEMTDTQYKECTA 411
Query: 363 EIKKL-EFEGYHFEAAEASLELLIERLR-GRYKPFFEL 398
+IK + + + A++ + L+ G KP +L
Sbjct: 412 KIKAMADIRPIAVDDADSIIRAYHRNLKSGENKPLLDL 449
>sp|O04973|LU1A_LYCPN 2-ISOPROPYLMALATE SYNTHASE A (ALPHA-ISOPROPYLMALATE SYNTHASE A)
(ALPHA-IPM SYNTHETASE A) >gi|2213882|gb|AAB61598.1|
(AF004165) 2-isopropylmalate synthase [Lycopersicon
pennellii]
Length = 589
Score = 150 bits (376), Expect = 3e-35
Identities = 141/559 (25%), Positives = 260/559 (46%), Gaps = 75/559 (13%)
Query: 7 VELYDTTLRDGSQMEGISFSLEDKLKITEKLDEFGIHYIEGGWPGSNPKDIQYFKAVRDL 66
V ++DTTLRDG Q G + + ++KL + +L + G+ IE G+P S+ D + K + +
Sbjct: 48 VRIFDTTLRDGEQSPGATMTTKEKLDVARQLAKLGVDIIEAGFPASSEADFESVKLIAEE 107
Query: 67 PLENAKIAAF-----GSTRRPRLRPEEDPNLNALVESEAPIATIFGKSWDLHVTEALRTT 121
N F G +R + + D A+ ++ P F + ++H+ L+ +
Sbjct: 108 IGNNTDENGFVPVICGLSRCN--KSDIDKAWEAVKYAKKPRVHTFIATSEIHMKYKLKMS 165
Query: 122 LENNIQMIIDSIEYLRDHGMV-VFYDAEHFFDGYRENPEYAMKTIKAAEEAGAERIVLAD 180
E ++ + Y R G V + E D R + E+ + +AGA + + D
Sbjct: 166 REQVVEKARSMVAYARSLGCEDVEFSPE---DAGRSDREFLYDILGEVIKAGATTLNIPD 222
Query: 181 TNGGSLPSFIKEVVEKVKEEVKTP------LGIHAHNDSELAVANSLIAFEAGVVQIQGT 234
T G ++PS +++ +K TP + H ND L+ AN+L AG Q++ T
Sbjct: 223 TVGYTVPSEFGQLITDIK--ANTPGIENVIISTHCQNDLGLSTANTLAGACAGARQLEVT 280
Query: 235 INGYGERCGNANLISIIPALELKYGVEVVG----KERLRKLKELAHFVAELANMEIPRNQ 290
ING GER GNA+L ++ AL+ + G +V+G + + + V E + +++ ++
Sbjct: 281 INGIGERAGNASLEEVVMALKCR-GEQVLGGLYTGINTQHIVPSSKMVEEYSGLQVQPHK 339
Query: 291 PYVGDSAFAHKGGVHVSAVLKNPRTYEHIDPELVG----NRRKVVVSELSGRSNLIYKAK 346
VG +AFAH+ G+H +LK+ TYE I P+ VG N +V+ +LSGR L K
Sbjct: 340 AIVGANAFAHESGIHQDGMLKHKDTYEIISPDDVGLSRSNEAGIVLGKLSGRHALKSKML 399
Query: 347 ELGIELEERDI-------KRIVEEIKKLEFEGYHFEAAEASLELLIERLRGRYKPFFELE 399
ELG +++ +++ K + E+ KK+ + A S E+L + +++L
Sbjct: 400 ELGYDIDGKELEDLFWRFKSVAEKKKKITDDDL---IALMSDEVLQPNV------YWKLG 450
Query: 400 RARVITEIFQGQPPISEANV-VVRVNSRRVHTTAEGNGPVN----ALDLALRKALTKFYP 454
+++ G +S A V ++ + + + G GPV+ A+DL ++ +T
Sbjct: 451 DVQIMC----GSLGLSTATVKLINTDGQEHIACSVGTGPVDAAYKAVDLIVKVPIT---- 502
Query: 455 ELKEIKLVDYKVRVLGSEKGTAAKVRVLVQTSDG------------KKTWGTVGASTNII 502
L++Y + + A RV + + D +T+ GA +++
Sbjct: 503 ------LLEYSMNAVTEGIDAIASTRVSICSIDRHTIMNGSTGQTIHRTFSGTGADMDVV 556
Query: 503 EASLNAIMESMEYWLMKER 521
+S+ A + ++ L E+
Sbjct: 557 ISSVRAYIGALNKMLSYEK 575
>sp|P15875|LEU1_SALTY 2-ISOPROPYLMALATE SYNTHASE (ALPHA-ISOPROPYLMALATE SYNTHASE)
(ALPHA-IPM SYNTHETASE) >gi|79038|pir||S08431
2-isopropylmalate synthase (EC 4.1.3.12) - Salmonella
typhimurium >gi|47968|emb|CAA35931.1| (X51583)
isopropylmalate synthase (AA 1-522) [Salmonella
typhimurium]
Length = 522
Score = 150 bits (374), Expect = 5e-35
Identities = 142/544 (26%), Positives = 241/544 (44%), Gaps = 59/544 (10%)
Query: 3 MKRRVELYDTTLRDGSQMEGISFSLEDKLKITEKLDEFGIHYIEGGWPGSNPKDIQYFKA 62
M ++V ++DTTLRDG Q S S ++KL+I L+ G+ +E G+P S+P D + +
Sbjct: 1 MSQQVIIFDTTLRDGEQALQASLSAKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT 60
Query: 63 VRDLPLENAKIAAFGSTRRPRLRPEEDPNLNALVESEAPIATIFGKSWDLHVTEALRTTL 122
+ ++N+++ A + + D AL ++A F + +H+ LR TL
Sbjct: 61 IART-IKNSRVCALARC----VEKDIDVAAQALKVADAFRIHTFIATSPMHIATKLRRTL 115
Query: 123 ENNIQMIIDSIEYLRDHGMVVFYDAEHFFDGYRENPEYAMKTIKAAEEAGAERIVLADTN 182
+ I+ + ++ R++ V + E D R + + ++AA AGA I + DT
Sbjct: 116 DEVIERAVYMVKRARNYTDDVEFSCE---DAGRTPVDDLARVVEAAINAGARTINIPDTV 172
Query: 183 GGSLP----SFIKEVVEKVKEEVKTPLGIHAHNDSELAVANSLIAFEAGVVQIQGTINGY 238
G ++P I + E+V K + +H H+D +AV NSL A AG Q++G +NG
Sbjct: 173 GYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGIAVGNSLAAVHAGARQVEGAMNGI 232
Query: 239 GERCGNANLISIIPALELKYGV-EVVGKERLRKLKELAHFVAELANMEIPRNQPYVGDSA 297
GER GN L +I A++++ + V + A ++ N+ P Q
Sbjct: 233 GERAGNCALEEVIMAIKVRKDIMNVHTNINHHETGAPARPSVQICNIADPSQQSDCRQRR 292
Query: 298 FAHKGGVHVSAVLKNPRTYEHIDPELVGNRRKVVVSEL----------SGRSNLIYKAKE 347
F H G+H VLKN YE + PE +G+ +L GR L
Sbjct: 293 FRHSSGIHQDGVLKNRENYEIMTPESIGSEPDTAEPDLPLWPCRRETSHGRDGL------ 346
Query: 348 LGIELEERDIKRIVEEI--KKLEFEGYHFEAAEASLELLIERLRGRYKPFFELERARVIT 405
G L+ R V E KK + Y EA L + F L+
Sbjct: 347 QGHRLQHGPPVRRVPEAGDKKGQVFDYDLEA------LAFINKQQEEPEHFRLD----YF 396
Query: 406 EIFQGQPPISEANVVVRVNSRRVHTTAEGNGPVNALDLALRKALTKFYPELKEIKLVDYK 465
+ G I+ A+V + A GNGPV+A+ A+ + +T + +++LV Y
Sbjct: 397 SVQSGSSDIATASVKLACGEEIKAEAANGNGPVDAIYQAINR-ITGY-----DVELVKYD 450
Query: 466 VRVLG-SEKGTAAKVRVLVQTSDGKKTWGTV---GASTNIIEASLNAIMESM-EYWLMKE 520
+ G + + + + R + +W + G +T+I+E+S A++ + W E
Sbjct: 451 LNAKGRARRAGSGRYR-------REPSWSPLPRRGLATDIVESSAKAMVHVLNNIWRAAE 503
Query: 521 REKD 524
EK+
Sbjct: 504 VEKE 507
>sp|P54610|NIFV_FRASP HOMOCITRATE SYNTHASE >gi|1280032|gb|AAB36875.1| (U53363)
homocitrate synthase [Frankia sp.]
Length = 401
Score = 148 bits (371), Expect = 1e-34
Identities = 113/362 (31%), Positives = 173/362 (47%), Gaps = 23/362 (6%)
Query: 7 VELYDTTLRDGSQMEGISFSLEDKLKITEKLDEFGIHYIEGGWPGSNPKDIQYFKAVRDL 66
V DTTLRDG Q G++F+ +KL I LD G+H IE G PG + +R++
Sbjct: 22 VRFCDTTLRDGEQAPGVAFTAAEKLAIAGALDAIGVHQIEAGIPGMGVTERD---VLREI 78
Query: 67 PLENAKIAAFGSTRRPRLRPEEDPNLNALVESEAPIATIFGKSWDLHVTEALRTTLENNI 126
+ K G R R E LV + I DLH+ L
Sbjct: 79 LATDPKAEIVGWCRADH-RDVEAAASCGLVTAHLTIPVS-----DLHLKSKLERDRAWAR 132
Query: 127 QMIIDSIEYLRDHGMVVFYDAEHFFDGYRENPEYAMKTIKAAEEAGAERIVLADTNGGSL 186
+ + D + D GM V + F D R + + + G R+ ADT G
Sbjct: 133 RRVRDCVVDGTDRGMRV---SVGFEDASRADDAFVTDLAGELRDVGVTRLRWADTVGLLD 189
Query: 187 PSFIKEVVEKVKEEVKTPLGIHAHNDSELAVANSLIAFEAGVVQIQGTINGYGERCGNAN 246
P + + ++ V P IHAH+D LA AN++ A +AG + T+ G GER GNA
Sbjct: 190 PVSAYDRLGRLVRAVPGPWEIHAHDDFGLATANTIAAVQAGFTWVSTTVLGLGERAGNAP 249
Query: 247 LISIIPALE--LKYGVEVVGKERLRKLKELAHFVAELANMEIPR-NQPYVGDSAFAHKGG 303
+ + AL LK ++ + R L +L + +P + VG+S FAH+ G
Sbjct: 250 IEEVAMALRHLLKLPID-LDTTSFRTLAQL------VVGWPLPAGKKAVVGESVFAHESG 302
Query: 304 VHVSAVLKNPRTYEHIDPELVGNRRKVVVSELSGRSNLIYKAKELGIELEERDIKRIVEE 363
+HV +L++P TYE DPE VG RR++ V + SGR++L + ++ GI EE +++ +VE+
Sbjct: 303 IHVHGILRHPATYEPFDPE-VGGRRRLTVGKHSGRASLRHALEQCGITAEESELEPLVEQ 361
Query: 364 IK 365
++
Sbjct: 362 VR 363
>pir||D75418 homocitrate synthase - Deinococcus radiodurans (strain R1)
>gi|6458984|gb|AAF10811.1|AE001972_1 (AE001972)
homocitrate synthase [Deinococcus radiodurans]
Length = 393
Score = 148 bits (370), Expect = 1e-34
Identities = 115/388 (29%), Positives = 182/388 (46%), Gaps = 29/388 (7%)
Query: 1 MLMKRRVELYDTTLRDGSQMEGISFSLEDKLKITEKLDEFGIHYIEGGWPGSNPKDIQYF 60
++ R + D+TLR+G Q +F +DK++I LD FG YIE P + + Q
Sbjct: 13 LIPARSWAIIDSTLREGEQFARGNFGTDDKVEIARALDAFGAEYIEVTTPMVSEQTRQDI 72
Query: 61 KAVRDLPLENAKIAAFGSTRRPRLRPEEDPNLNALVESEAPIATIFGKSWDLHVTEALRT 120
+ + L L AK ++ D ++ L +FG S L
Sbjct: 73 RKLTGLGLR-AKFLTHVRCHMEDVQRAVDTGVDGL-------DLLFGTSSFLR-----EF 119
Query: 121 TLENNIQMIIDS----IEYLRDHG--MVVFYDAEHFFDGYRENPEYAMKTIKAAEEAGAE 174
+ +I IID+ I +++ H + + + AE D +R M A E G
Sbjct: 120 SHGKSIAQIIDTAGEVIGWIKTHHPELEIRFSAE---DTFRSEEADLMAVYSAVSELGVH 176
Query: 175 RIVLADTNGGSLPSFIKEVVEKVKEEVKTPLGI--HAHNDSELAVANSLIAFEAGVVQIQ 232
R+ LADT G + P + +V +V++ + GI H HND+ AV+N+ A EAG I
Sbjct: 177 RVGLADTVGVATPRQVYTLVREVRKVIHEGCGIEFHGHNDTGCAVSNAYEAIEAGATHID 236
Query: 233 GTINGYGERCGNANLISIIPALELKYGVEVVGKERLRKLKELAHFVAELANMEIPRNQPY 292
TI G GER G L ++ + ++ K L L EL +A + ++ +P N
Sbjct: 237 TTILGIGERNGITPLGGLLARMFTFDPQGLIDKYNLELLPELDRMIARMVDLPVPWNNYL 296
Query: 293 VGDSAFAHKGGVHVSAVLKNPRTYEHIDPELVG-NRRKVVVSELSGRSNLIYKAKELGIE 351
G+ A+ HK G+H+ A+ NP YE I P + G RR S+++G+ + YKA+ELG+
Sbjct: 297 TGEFAYNHKAGMHLKAIYLNPGAYEAIPPGVFGVGRRIQAASKVTGKHAIAYKARELGLH 356
Query: 352 LEERDIKRIVEEIKKL----EFEGYHFE 375
E ++R+ + IK L E + H E
Sbjct: 357 YGEDALRRVTDHIKSLAEQDELDDAHLE 384
>sp|Q47884|NIFV_FRAAL HOMOCITRATE SYNTHASE >gi|1256029|gb|AAA96261.1| (L41344)
homocitrate synthase [Frankia alni]
Length = 351
Score = 147 bits (368), Expect = 2e-34
Identities = 108/347 (31%), Positives = 162/347 (46%), Gaps = 22/347 (6%)
Query: 7 VELYDTTLRDGSQMEGISFSLEDKLKITEKLDEFGIHYIEGGWP--GSNPKDIQYFKAVR 64
++ DTTLRDG Q G++F+ +KL I LD G+H IE G P G +D+ +R
Sbjct: 23 IKFCDTTLRDGEQAPGVAFTAAEKLAIAAALDAIGVHQIEAGIPAMGVTERDV-----LR 77
Query: 65 DLPLENAKIAAFGSTRRPRLRPEEDPNLNALVESEAPIATIFGKSWDLHVTEALRTTLEN 124
++ + G R R E LV + I DLH+ L
Sbjct: 78 EILATDPHADIVGWCRADH-RDVEAAASCGLVTAHLTIPVS-----DLHLKSKLGRDRAW 131
Query: 125 NIQMIIDSIEYLRDHGMVVFYDAEHFFDGYRENPEYAMKTIKAAEEAGAERIVLADTNGG 184
+ D + D GM V + F D R + + E G R+ ADT G
Sbjct: 132 ARLRVRDCVADATDRGMRV---SVGFEDASRADDAFVTDLAGELRELGVTRLRWADTVGL 188
Query: 185 SLPSFIKEVVEKVKEEVKTPLGIHAHNDSELAVANSLIAFEAGVVQIQGTINGYGERCGN 244
P + + ++ V P IHAH+D LA AN++ A +AG + T+ G GER GN
Sbjct: 189 LDPVSAHDRLGRLVRAVPGPWEIHAHDDFGLATANTIAAVQAGFTWVSTTVLGLGERAGN 248
Query: 245 ANLISIIPALE--LKYGVEVVGKERLRKLKELAHFVAELANMEIPRNQPYVGDSAFAHKG 302
A + + AL LK V++ + LA V+ A +P + VG+S FAH+
Sbjct: 249 APIEEVAMALRHLLKLPVDL----DTTSFRSLARLVSRAARRPLPAGKAVVGESVFAHES 304
Query: 303 GVHVSAVLKNPRTYEHIDPELVGNRRKVVVSELSGRSNLIYKAKELG 349
G+HV +L++P TYE DP VG RR++ + + SGR+++ Y ++ G
Sbjct: 305 GIHVHGILRHPATYEPFDPAEVGGRRRLAIGKHSGRASVRYALEQYG 351
>sp|O04974|LU1B_LYCPN 2-ISOPROPYLMALATE SYNTHASE B (ALPHA-ISOPROPYLMALATE SYNTHASE B)
(ALPHA-IPM SYNTHETASE B) >gi|2213884|gb|AAB61599.1|
(AF004166) 2-isopropylmalate synthase [Lycopersicon
pennellii]
Length = 612
Score = 147 bits (368), Expect = 2e-34
Identities = 137/550 (24%), Positives = 254/550 (45%), Gaps = 73/550 (13%)
Query: 7 VELYDTTLRDGSQMEGISFSLEDKLKITEKLDEFGIHYIEGGWPGSNPKDIQ----YFKA 62
V ++DTTLRDG Q G + + ++KL + + + G+ IE G+P S+ D++ K
Sbjct: 71 VRIFDTTLRDGEQSPGATMTTKEKLDVARQSAKLGVDIIEAGFPASSEADLEAVKLIAKE 130
Query: 63 VRDLPLENAKIAAFGSTRRPRLRPEEDPNLNALVESEAPIATIFGKSWDLHVTEALRTTL 122
V + E + R + + D A+ ++ P F + ++H+ L+ +
Sbjct: 131 VGNGVYEEEYVPVICGLARCN-KKDIDKAWEAVKYAKKPRIHTFIATSEVHMNYKLKMSR 189
Query: 123 ENNIQMIIDSIEYLRDHGMV-VFYDAEHFFDGYRENPEYAMKTIKAAEEAGAERIVLADT 181
+ ++ + Y R G V + E D R +PE+ + +AGA + + DT
Sbjct: 190 DQVVEKARSMVAYARSIGCEDVEFSPE---DAGRSDPEFLYHILGEVIKAGATTLNIPDT 246
Query: 182 NGGSLPSFIKEVVEKVKEEVKTP------LGIHAHNDSELAVANSLIAFEAGVVQIQGTI 235
G ++P +++ K+K TP + H ND L+ AN+L AG Q++ TI
Sbjct: 247 VGYTVPEEFGQLIAKIK--ANTPGVEDVIISTHCQNDLGLSTANTLAGACAGARQLEVTI 304
Query: 236 NGYGERCGNANLISIIPALELKYGVEVVG----KERLRKLKELAHFVAELANMEIPRNQP 291
NG GER GNA+L ++ AL+ + G +V+G + + + V ++ + + ++
Sbjct: 305 NGIGERAGNASLEEVVMALKCR-GEQVLGGLYTGINTQHILMSSKMVEGISGLHVQPHKA 363
Query: 292 YVGDSAFAHKGGVHVSAVLKNPRTYEHIDPELVG----NRRKVVVSELSGRSNLIYKAKE 347
VG +AF H+ G+H +LK+ TYE I PE +G N +V +LSG K E
Sbjct: 364 IVGANAFVHESGIHQDGMLKHKDTYEIISPEDIGLNRANESGIVFGKLSGVMLCKPKMLE 423
Query: 348 LGIELEERDI-------KRIVEEIKKLEFEGYHFEAAEASLELLIERLRGRYKPFFELER 400
LG E+E +++ K + E+ KK+ + + L+ + + ++P F +
Sbjct: 424 LGYEIEGKELDDLFWRFKSVAEKKKKI--------TDDDLVALMSDEV---FQPQFVWQL 472
Query: 401 ARVITEIFQGQPPISEANV-VVRVNSRRVHTTAEGNGPVN----ALDLALRKALTKFYPE 455
V ++ G +S A V ++ + R + + G GPV+ A+DL ++ +T
Sbjct: 473 QNV--QVTCGSLGLSTATVKLIDADGREHISCSVGTGPVDAAYKAVDLIVKVPVT----- 525
Query: 456 LKEIKLVDYKVRVLGSEKGTAAKVRVLVQTSDG------------KKTWGTVGASTNIIE 503
L++Y + + A RVL++ +G +T+ GA +I+
Sbjct: 526 -----LLEYSMNAVTQGIDAIASTRVLIRGENGHTSTHALTGETVHRTFSGTGADMDIVI 580
Query: 504 ASLNAIMESM 513
+S+ A + ++
Sbjct: 581 SSVRAYVGAL 590
>gb|AAG31380.1| (AF197449) 2-isopropylmaltate synthase [Buchnera aphidicola]
Length = 486
Score = 146 bits (365), Expect = 5e-34
Identities = 134/504 (26%), Positives = 246/504 (48%), Gaps = 41/504 (8%)
Query: 37 LDEFGIHYIEGGWPGSNPKDIQYFKAVRDLP--LENAKIAAFGSTRRPRLRPEEDPNLNA 94
L++ G+ +E G+P S+P D FK+V+ + ++N++I + + + D A
Sbjct: 6 LEKAGVDIMEVGFPISSPGD---FKSVQIISQHIKNSRICSLARC----IEKDIDAAGEA 58
Query: 95 LVESEAPIATIFGKSWDLHVTEALRTTLENNIQMIIDSIEYLRDHGMVVFYDAEHFFDGY 154
+ S+A IF + LH+ LR + I M I S++ + + + E D
Sbjct: 59 MSVSDAFRIHIFLATSTLHMESKLRKNFDEIIDMAIFSVKRALRYTDDIEFSCE---DAS 115
Query: 155 RENPEYAMKTIKAAEEAGAERIVLADTNGGSLPSFIKEVVEKVKEEVKTPLGI----HAH 210
R + + ++ G + I + DT G ++P+ + H H
Sbjct: 116 RTTIDNLCRIVEKLISFGVKTINIPDTVGYTVPNELSXXXXXXXXXXXXXXXXXXXXHCH 175
Query: 211 NDSELAVANSLIAFEAGVVQIQGTINGYGERCGNANLISIIPALELKYGVEVVGKERLRK 270
+D +AV NS+ A +AG QI+GTING GER GN L +I A++++ +++G
Sbjct: 176 DDLGMAVGNSISAIQAGARQIEGTINGIGERAGNTALEEVIMAIKVR--EDILGLSTNIN 233
Query: 271 LKEL---AHFVAELANMEIPRNQPYVGDSAFAHKGGVHVSAVLKNPRTYEHIDPELVGNR 327
KE+ + V+ + NM IP N+ VG +AF+H G+H VLKN YE +DP +G +
Sbjct: 234 YKEIYRTSQIVSRICNMPIPSNKAIVGSNAFSHSSGIHQDGVLKNRENYEIMDPSSIGLK 293
Query: 328 R-KVVVSELSGRSNLIYKAKELGIELEERDIKRIVEEIKKL-EFEGYHFEAAEASLELLI 385
R K+ ++ SGR+ + Y E+G + ++ +I + + KL + +G F+ +L +
Sbjct: 294 RVKLNLTSRSGRAAVKYYMSEMGYKEDDYNIDELYTDFLKLADKKGQVFDYDLEALAFI- 352
Query: 386 ERLRGRYKPFFELERARVITEIFQGQPPISEANVVVRVNSRRVHTTAE--GNGPVNALDL 443
+ +F L+ + +S A+V + + ++++T A NGPV+A+
Sbjct: 353 -NKQQDESEYFSLK----FFSVQSISNNLSTASVTL-LCGKKIYTEASTTSNGPVDAIYQ 406
Query: 444 ALRKALTKFYPELKEIKLVDYKVRVLGSEKGTAAKVRVLVQTSDGKKTWGTVGASTNIIE 503
AL + +T F L++ +L+ G + +V +LV+ K+ + VG +T+I+E
Sbjct: 407 ALNR-ITHFPIILQKFQLI-----AKGKGRDALGQVDILVEYK--KRKFHGVGLATDIME 458
Query: 504 ASLNAIMESM-EYWLMKEREKDEK 526
+S A++ + W K+ K+ K
Sbjct: 459 SSAKAMVNVLNNIWKAKQVNKNLK 482
>gb|AAF26002.1|AC013354_21 (AC013354) F15H18.3 [Arabidopsis thaliana]
Length = 675
Score = 143 bits (356), Expect = 6e-33
Identities = 146/572 (25%), Positives = 250/572 (43%), Gaps = 73/572 (12%)
Query: 7 VELYDTTLRDGSQMEGISFSLEDKLKITEKLDEFGIHYIEGGWPGSNPKDIQYFKAVRD- 65
V ++DTTLRDG Q G + + ++KL I +L + G+ IE G+P ++ D + K + +
Sbjct: 89 VRVFDTTLRDGEQSPGATLTSKEKLDIARQLAKLGVDIIEAGFPAASKDDFEAVKTIAET 148
Query: 66 ---LPLENAKIAAFGSTRRPRLRPEEDPNLNALVESEAPIATIFGKSWDLHVTEALRTTL 122
EN + R + + + +A+ ++ P F + D+H+ L+ T
Sbjct: 149 VGNTVDENGYVPVICGLSRCN-KKDIERAWDAVKYAKRPRIHTFIATSDIHLEYKLKKTK 207
Query: 123 ENNIQMIIDSIEYLRDHGMV-VFYDAEHFFDGYRENPEYAMKTIKAAEEAGAERIVLADT 181
I++ + + R G V + E D R EY + + +AGA + + DT
Sbjct: 208 AEVIEIARSMVRFARSLGCEDVEFSPE---DAGRSEREYLYEILGEVIKAGATTLNIPDT 264
Query: 182 NGGSLPSFIKEVVEKVKEEV----KTPLGIHAHNDSELAVANSLIAFEAGVVQIQGTING 237
G +LPS +++ +K + H ND L+ AN+L AG Q++ TING
Sbjct: 265 VGITLPSEFGQLITDLKANTPGIENVVISTHCQNDLGLSTANTLSGAHAGARQMEVTING 324
Query: 238 YGERCGNANLISIIPALELKYGVEVVG----KERLRKLKELAHFVAELANMEIPRNQPYV 293
GER GNA+L ++ A++ + G V+G R + + V E M+ ++ V
Sbjct: 325 IGERAGNASLEEVVMAIKCR-GDHVLGGLFTGIDTRHIVMTSKMVEEYTGMQTQPHKAIV 383
Query: 294 GDSAFAHKGGVHVSAVLKNPRTYEHIDPELVGNRRK----VVVSELSGRSNLIYKAKELG 349
G +AFAH+ G+H +LK+ TYE I PE +G R +V+ +LSGR L + E+
Sbjct: 384 GANAFAHESGIHQDGMLKHKGTYEIICPEEIGLERSNDAGIVLGKLSGRHALKDRLTEVH 443
Query: 350 IELEERD--IKRIVEEIKKLEFEGYHFEAAEASLELLIERLRGRYKPFFELER------- 400
L + I V + L HF+ + + + R+K E ++
Sbjct: 444 SNLTHTNTCIAIFVGDTNVL-LSFVHFQLGYQLDDEQLSTIFWRFKTVAEQKKRVTDADI 502
Query: 401 -ARVITEIFQ--------------GQPPISEANVVVRVNSRRVHTTAE-GNGPVNA---- 440
A V E+FQ G +S A V + + H G GPV++
Sbjct: 503 IALVSDEVFQPEAVWKLLDIQITCGTLGLSTATVKLADADGKEHVACSIGTGPVDSAYKA 562
Query: 441 -------LDLALRKALTKFYPELKEIKLVDYKVRVLGSEKGTAAKVRVLVQTS------- 486
L + LR + T PE L++Y + + A RVL++ S
Sbjct: 563 VDLIVKVLFIPLRLSSTNNSPE--PATLLEYSMNAVTEGIDAIATTRVLIRGSNKYSSTN 620
Query: 487 -----DGKKTWGTVGASTNIIEASLNAIMESM 513
+ ++T+ GA +I+ +S+ A + ++
Sbjct: 621 AITGEEVQRTFSGTGAGMDIVVSSVKAYVGAL 652
>emb|CAA72697.1| (Y11966) 2-isopropylmalate synthase [Buchnera aphidicola]
Length = 375
Score = 142 bits (354), Expect = 1e-32
Identities = 101/364 (27%), Positives = 190/364 (51%), Gaps = 22/364 (6%)
Query: 163 KTIKAAEEAGAERIVLADTNGGSLPSFIKEVVEKVKEEV----KTPLGIHAHNDSELAVA 218
+ +++A +AGA I + DT G ++PS K +++ + +V + H H+D LAV
Sbjct: 10 RIVESAIKAGATTINIPDTVGYTIPSQFKTIIKNLFNKVPNINNAIISAHCHDDLGLAVG 69
Query: 219 NSLIAFEAGVVQIQGTINGYGERCGNANLISIIPALELKYG-VEVVGKERLRKLKELAHF 277
N++ + EAGV QI+GTI+G GER GN L +I ++LK + V + +L +
Sbjct: 70 NAIASIEAGVRQIEGTISGIGERAGNTALEEVILTIKLKEELLNVFTNIKHNELYRTSQL 129
Query: 278 VAELANMEIPRNQPYVGDSAFAHKGGVHVSAVLKNPRTYEHIDPELVGNRR-KVVVSELS 336
+++L N IP N+ +G +AFAH G+H +LKN YE IDP+ +G + ++ ++ S
Sbjct: 130 ISQLCNTPIPANKSIIGSNAFAHSSGIHQDGILKNRANYEIIDPKTIGVKAVQLNLTSRS 189
Query: 337 GRSNLIYKAKELGIELEERDIKRI-VEEIKKLEFEGYHFEAAEASLELLIERLRGRYKPF 395
GR+ + + E+G + ++ D+ ++ V +K + +G F+ +L I + +
Sbjct: 190 GRAAVKHHMHEMGYQDDDYDLNQLYVNFLKLADKKGQVFDYDLEAL-AFISNQEDKDQEH 248
Query: 396 FELERARVITEIFQGQPPISEANVVVRVNSRRVH-TTAEGNGPVNALDLALRKALTKFYP 454
F+L+ I G +S A+V + ++ ++ NGP+N++ AL
Sbjct: 249 FQLK----YFSIHSGSTGVSTASVKLLCGNKILNEIITTRNGPINSIYQALN-------- 296
Query: 455 ELKEIKLVDYKVRVLGSEKGTAAKVRVLVQTSDGKKTWGTVGASTNIIEASLNAIMESM- 513
+ + +V K ++G +G A +V + + + +G +T+IIE+S+ A++ +
Sbjct: 297 NIAGLPIVLEKFHLVGKGEGRDALGQVDIVVKYNNRKFHGIGLATDIIESSIKAMLNVLN 356
Query: 514 EYWL 517
WL
Sbjct: 357 NIWL 360
>pir||S02508 homocitrate synthase (EC 4.1.3.21) - Klebsiella pneumoniae
>gi|43832|emb|CAA31676.1| (X13303) nifV protein (AA
1-380) [Klebsiella pneumoniae]
Length = 380
Score = 136 bits (340), Expect = 5e-31
Identities = 108/361 (29%), Positives = 167/361 (45%), Gaps = 14/361 (3%)
Query: 6 RVELYDTTLRDGSQMEGISFSLEDKLKITEKLDEFGIHYIEGGWPGSNPKDIQYFKAVRD 65
RV + DTTLRDG Q G++F +K+ I E L GI +E G P ++I + VR
Sbjct: 3 RVLINDTTLRDGEQSPGVAFRTSEKVAIAEALYAAGITAMEVGTPAMGDEEIARIQLVRR 62
Query: 66 LPLENAKIAAFGSTRRPRLRPEEDPNLNALVESEAPIATIFGKSWDLHVTEALRTTLENN 125
L +A + + +R D ++ V+ P + K + E L LE
Sbjct: 63 -QLPDATLMTWCRMNALEIRQSADLGID-WVDISIPASD---KLRQYKLREPLAVLLER- 116
Query: 126 IQMIIDSIEYLRDHGMVVFYDAEHFFDGYRENPEYAMKTIKAAEEAGAERIVLADTNGGS 185
+ M I L G+ V E D R + + + A++ A R+ ADT G
Sbjct: 117 LAMFIHLAHTL---GLKVCIGCE---DASRASGQTLRAIAEVAQQCAAARLRYADTVGLL 170
Query: 186 LPSFIKEVVEKVKEEVKTPLGIHAHNDSELAVANSLIAFEAGVVQIQGTINGYGERCGNA 245
P + +++ + +HAHND +A AN+L A AG + T+ G GER GNA
Sbjct: 171 DPFTTAAQISALRDVWSGEIEMHAHNDLGMATANTLAAVSAGATSVNTTVLGLGERAGNA 230
Query: 246 NLISIIPALELKYGVEVVGKERLRKLKELAHFVAELANMEIPRNQPYVGDSAFAHKGGVH 305
L ++ LE GVE L VAE A I QP VG+ F H+ GVH
Sbjct: 231 ALETVALGLERCLGVET--GVHFSALPASCQRVAEAAQRAIDPQQPLVGELVFTHESGVH 288
Query: 306 VSAVLKNPRTYEHIDPELVGNRRKVVVSELSGRSNLIYKAKELGIELEERDIKRIVEEIK 365
V+A+L++ +Y+ I P L+G ++V+ + SGR + ++G L I +++ I+
Sbjct: 289 VAALLRHSESYQSIAPSLMGRSYRLVLGKHSGRQAVNGVFDQMGYHLNAAQINQLLPAIR 348
Query: 366 K 366
+
Sbjct: 349 R 349
>sp|Q07179|NIFV_RHOCA HOMOCITRATE SYNTHASE >gi|486695|pir||S34817 nifV protein -
Rhodobacter capsulatus >gi|297919|emb|CAA48488.1|
(X68444) nifV [Rhodobacter capsulatus]
Length = 382
Score = 136 bits (339), Expect = 6e-31
Identities = 112/375 (29%), Positives = 170/375 (44%), Gaps = 42/375 (11%)
Query: 1 MLMKRRVELYDTTLRDGSQMEGISFSLEDKLKITEKLDEFGIHYIEGGWPGSNPKDIQYF 60
M R + L DTTLRDG Q G++FSL +K I LD G+ IE G ++
Sbjct: 1 MTPDRTLALCDTTLRDGEQTAGVAFSLAEKKAIARALDRAGVAEIEVGIAAMGWAEVAEI 60
Query: 61 KAVRD------------LPLENAKIAAFGSTRRPRLRPEEDPNLNALVESEAPIATIFGK 108
+AV L + + +A +R P A +E + + +
Sbjct: 61 RAVVAEIAHATPVVWCRLRMHDLDMAQKTGVKRVHFAV---PTSTAQLEGKLRV----DR 113
Query: 109 SWDLHVTEALRTTLENNIQMIIDSIEYLRDHGMVVFYDAEHFFDGYRENPEYAMKTIKAA 168
W L T AL + D G+ V AE D R +P++ ++ + A
Sbjct: 114 DWILRETAAL--------------VFCASDRGLQVSVGAE---DASRTDPDFLIRLAEVA 156
Query: 169 EEAGAERIVLADTNGGSLPSFIKEVVEKVKEEVKTPLGIHAHNDSELAVANSLIAFEAGV 228
AGA R +ADT G P +V ++ + P+ +HAHND +A AN+++A AG
Sbjct: 157 AAAGAIRFRIADTLGLLDPLGAFRLVAELSARISLPIEMHAHNDFGMATANTIMAAHAGA 216
Query: 229 VQIQGTINGYGERCGNANLISIIPALELKYGVEVVGKERLRKLKELAHFVAELANMEIPR 288
+ T+NG GER GNA + ALE G++ G + L L EL+ VA+ +
Sbjct: 217 THLSVTVNGLGERAGNAACEEVGAALEAG-GID-TGLD-LCALPELSAVVAKASGRAFRA 273
Query: 289 NQPYVGDS-AFAHKGGVHVSAVLKNPRTYE--HIDPELVGNRRKVVVSELSGRSNLIYKA 345
+P GD FAH+ G+HV A+LK TYE P G R++V+ + SG + L
Sbjct: 274 QKPITGDDWLFAHESGIHVDAILKRADTYEDPRCAPARFGRERQIVIGKHSGSAGLRAAL 333
Query: 346 KELGIELEERDIKRI 360
E G+ ++ + R+
Sbjct: 334 LEAGLPADDAVLDRL 348
>sp|P05342|NIFV_AZOVI HOMOCITRATE SYNTHASE >gi|420863|pir||S29758 nifV protein -
Azotobacter vinelandii >gi|142362|gb|AAA64727.1|
(M20568) homocitrate synthase (nifV) [Azotobacter
vinelandii]
Length = 385
Score = 136 bits (339), Expect = 6e-31
Identities = 97/355 (27%), Positives = 173/355 (48%), Gaps = 14/355 (3%)
Query: 11 DTTLRDGSQMEGISFSLEDKLKITEKLDEFGIHYIEGGWPGSNPKDIQYFKAVRDLPLEN 70
DTTLRDG Q G++F+ ++K+ I L E G+ +E G P ++ + A+ L L +
Sbjct: 8 DTTLRDGEQSAGVAFNADEKIAIARALAELGVPELEIGIPSMGEEEREVMHAIAGLGL-S 66
Query: 71 AKIAAFGSTRRPRLRPEEDPNLNALVESEAPIATIFGKSWDLHVTEALRTTLENNIQMII 130
+++ A+ L + +V+ P++ DL + L + ++ +
Sbjct: 67 SRLLAWCRLCDVDLAAARSTGVT-MVDLSLPVS-------DLMLHHKLNRDRDWALREVA 118
Query: 131 DSIEYLRDHGMVVFYDAEHFFDGYRENPEYAMKTIKAAEEAGAERIVLADTNGGSLPSFI 190
+ R G+ V E D R + E+ ++ + A+ AGA R+ ADT G P +
Sbjct: 119 RLVGEARMAGLEVCLGCE---DASRADLEFVVQVGEVAQAAGARRLRFADTVGVMEPFGM 175
Query: 191 KEVVEKVKEEVKTPLGIHAHNDSELAVANSLIAFEAGVVQIQGTINGYGERCGNANLISI 250
+ + + L +HAH+D LA AN+L A G I T+NG GER GNA L
Sbjct: 176 LDRFRFLSRRLDMELEVHAHDDFGLATANTLAAVMGGATHINTTVNGLGERAGNAALEEC 235
Query: 251 IPALELKYGVEVVGKERLRKLKELAHFVAELANMEIPRNQPYVGDSAFAHKGGVHVSAVL 310
+ AL+ +G++ G + R + ++ V + ++ + VG F H+ G+HV +L
Sbjct: 236 VLALKNLHGID-TGID-TRGIPAISALVERASGRQVAWQKSVVGAGVFTHEAGIHVDGLL 293
Query: 311 KNPRTYEHIDPELVGNRRKVVVSELSGRSNLIYKAKELGIELEERDIKRIVEEIK 365
K+ R YE ++P+ +G +V+ + SG + ++LGIEL + + ++ I+
Sbjct: 294 KHRRNYEGLNPDELGRSHSLVLGKHSGAHMVRNTYRDLGIELADWQSQALLGRIR 348
>sp|Q56216|LEU1_THETH 2-ISOPROPYLMALATE SYNTHASE (ALPHA-ISOPROPYLMALATE SYNTHASE)
(ALPHA-IPM SYNTHETASE) >gi|1293674|gb|AAB01162.1|
(U52907) isopropylmalate synthase [Thermus thermophilus]
Length = 331
Score = 135 bits (336), Expect = 1e-30
Identities = 100/311 (32%), Positives = 160/311 (51%), Gaps = 17/311 (5%)
Query: 205 LGIHAHNDSELAVANSLIAFEAGVVQIQGTINGYGERCGNANLISIIPALELKYG-VEVV 263
+ H H+D +A AN+L E G QI+ TING GER GN L ++ AL ++ +
Sbjct: 12 ISTHTHDDLGMATANALAGVENGAGQIECTINGIGERAGNCALEEVVMALYVRRDWYKAY 71
Query: 264 GKERLRKLKELAHFVAELANMEIPRNQPYVGDSAFAHKGGVHVSAVLKNPRTYEHIDPEL 323
+ R++ ++ V M +P N+ VGD+AFAH+ G+H V+K+ TYE +D EL
Sbjct: 72 TRINTREIYRVSRLVERYTGMPVPPNKAIVGDNAFAHESGIHQDGVIKHRATYEIMDAEL 131
Query: 324 VGNRRKV-VVSELSGRSNLIYKAKELGI-ELEERDIKRIVEEIKKLEFEGYHFEAAEASL 381
+G R V V+ + SGR+ ++LG +L E ++K++ K++ + A E L
Sbjct: 132 IGRRPAVLVLGKHSGRAAFKKALEDLGYKDLSEEEVKKLFARFKEIAEKKGPLSAEE--L 189
Query: 382 ELLIERLRGRYKPFFELERARVITEIFQGQPPISEANVVVRVNSRRVHTTAEGNGPVNAL 441
+ L+E R FF+LE + F G + A V V+ T G+GPV+A+
Sbjct: 190 QALVESEREPTSHFFQLEH----VQFFSGSGLLPTATVKVKTPDGERLATHTGDGPVDAV 245
Query: 442 DLALRKALTKFYPELKEIKLVDYKVRVLGSEKGTAAKVRVLVQTSDGKKTWGTVGASTNI 501
A+++A+ PEL+ Y+V + T A +V V+ G+ VG S +I
Sbjct: 246 YKAIQEAI-GLRPELEL-----YRVEAITG--STEALGQVTVRLRLGELQAVGVGVSPDI 297
Query: 502 IEASLNAIMES 512
IEAS A +++
Sbjct: 298 IEASALAFLDA 308
>gb|AAA22169.1| (M17349) nifV protein [Azotobacter vinelandii]
Length = 385
Score = 133 bits (332), Expect = 4e-30
Identities = 96/355 (27%), Positives = 172/355 (48%), Gaps = 14/355 (3%)
Query: 11 DTTLRDGSQMEGISFSLEDKLKITEKLDEFGIHYIEGGWPGSNPKDIQYFKAVRDLPLEN 70
DTTLRDG Q G++F+ ++K+ I L E G+ +E G P ++ + A+ L L +
Sbjct: 8 DTTLRDGEQSAGVAFNADEKIAIARALAELGVPELEIGIPSMGEEEREVMHAIAGLGL-S 66
Query: 71 AKIAAFGSTRRPRLRPEEDPNLNALVESEAPIATIFGKSWDLHVTEALRTTLENNIQMII 130
+++ A+ L + +V+ P++ DL + L + ++ +
Sbjct: 67 SRLLAWCRLCDVDLAAARSTGVT-MVDLSLPVS-------DLMLHHKLNRDRDWALREVA 118
Query: 131 DSIEYLRDHGMVVFYDAEHFFDGYRENPEYAMKTIKAAEEAGAERIVLADTNGGSLPSFI 190
+ R G+ V E D R + E+ ++ + A+ AGA + ADT G P +
Sbjct: 119 RLVGEARMAGLEVCLGCE---DASRADLEFVVQVGEVAQAAGARPLRFADTVGVMEPFGM 175
Query: 191 KEVVEKVKEEVKTPLGIHAHNDSELAVANSLIAFEAGVVQIQGTINGYGERCGNANLISI 250
+ + + L +HAH+D LA AN+L A G I T+NG GER GNA L
Sbjct: 176 LDRFRFLSRRLDMELEVHAHDDFGLATANTLAAVMGGATHINTTVNGLGERAGNAALEEC 235
Query: 251 IPALELKYGVEVVGKERLRKLKELAHFVAELANMEIPRNQPYVGDSAFAHKGGVHVSAVL 310
+ AL+ +G++ G + R + ++ V + ++ + VG F H+ G+HV +L
Sbjct: 236 VLALKNLHGID-TGID-TRGIPAISALVERASGRQVAWQKSVVGAGVFTHEAGIHVDGLL 293
Query: 311 KNPRTYEHIDPELVGNRRKVVVSELSGRSNLIYKAKELGIELEERDIKRIVEEIK 365
K+ R YE ++P+ +G +V+ + SG + ++LGIEL + + ++ I+
Sbjct: 294 KHRRNYEGLNPDELGRSHSLVLGKHSGAHMVRNTYRDLGIELADWQSQALLGRIR 348
>sp|Q52070|NIFV_ENTAG HOMOCITRATE SYNTHASE >gi|1480128|emb|CAA68021.1| (X99694) nifV
[Enterobacter agglomerans]
Length = 400
Score = 133 bits (331), Expect = 5e-30
Identities = 105/364 (28%), Positives = 163/364 (43%), Gaps = 22/364 (6%)
Query: 7 VELYDTTLRDGSQMEGISFSLEDKLKITEKLDEFGIHYIEGGWPGSNPKDIQYFKAVRDL 66
V + DTTLRDG Q G++F +KL+I + L G+ +E G P ++ +R
Sbjct: 18 VIINDTTLRDGEQSPGVAFRASEKLEIAQALVNAGVRELEAGTPALGEEECVRLAILRR- 76
Query: 67 PLENAKIAAFGSTRRPRLRPEEDPNLNALVESEAPIATIFGKSWDLHVTEALRTTLENNI 126
L + + ++ + ++ V+ P + DL + L I
Sbjct: 77 QLPDTVMMSWCRMNSAEIHDSARVGMD-WVDISVPAS-------DLLREQKLHRPWPAVI 128
Query: 127 QMIIDSIEYLRDHGMVVFYDAEHFFDGYRENPEYAMKTIKAAEEAGAERIVLADTNGGSL 186
+ ++ GM V E D R E + A + G ER+ ADT G
Sbjct: 129 ASLKPLVQLAHRLGMRVCMGCE---DASRSADETLHMLAEVAADLGIERMRFADTLGILD 185
Query: 187 PSFIKEVVEKVKEEVKTPLGIHAHNDSELAVANSLIAFEAGVVQIQGTINGYGERCGNAN 246
P + +++ L IHAHND +A AN+L A AG + T+ G GER GNA
Sbjct: 186 PFSTFTRISALRQHWHGGLEIHAHNDLGMATANTLAAVRAGATHVNTTVLGLGERAGNAA 245
Query: 247 LISIIPALE----LKYGVEVVGKERLRKLKELAHFVAELANMEIPRNQPYVGDSAFAHKG 302
L S+ +L+ L G++ +L L VA A I P VG F H+
Sbjct: 246 LESVTLSLDRCLHLDCGIDFT------ELPALCRLVAAAAGRTIDVQHPLVGGQVFTHES 299
Query: 303 GVHVSAVLKNPRTYEHIDPELVGNRRKVVVSELSGRSNLIYKAKELGIELEERDIKRIVE 362
G+HV+A+L++PR+Y+ IDP LVG +V+ + SGR + LG L E +++
Sbjct: 300 GLHVAALLRDPRSYQGIDPSLVGREFNLVLGKHSGRQAVSGICARLGYILSETQTLLMLQ 359
Query: 363 EIKK 366
E+K+
Sbjct: 360 EVKR 363
>sp|Q01181|NIFV_RHOSH HOMOCITRATE SYNTHASE >gi|282178|pir||D41880 isopropylmalate
synthetase homolog NIfV - Rhodobacter sphaeroides
>gi|151969|gb|AAA26138.1| (M86823) nifV [Rhodobacter
sphaeroides]
Length = 391
Score = 132 bits (328), Expect = 1e-29
Identities = 105/365 (28%), Positives = 162/365 (43%), Gaps = 25/365 (6%)
Query: 7 VELYDTTLRDGSQMEGISFSLEDKLKITEKLDEFGIHYIEGGWPGSNPKDIQYFKAVRDL 66
V L DTTLRDG Q G++F+ +K I E L G+ +E G P ++ +AV +
Sbjct: 19 VALCDTTLRDGEQTAGVAFTRAEKRAIAEALQAAGVAEVEVGVPAMGEEERADIRAVAAV 78
Query: 67 PLENAKIAAFGSTRRPRLRPEEDPNLNAL----VESEAPIATIFGKSWDLHVTEALRTTL 122
L+ A + R L + + L SE I+ GK +
Sbjct: 79 -LKTAAPVVWCRLRAEDLAAAQRTGVVRLHIGVPVSERQISAKLGKD---------AAWV 128
Query: 123 ENNIQMIIDSIEYLRDHGMVVFYDAEHFFDGYRENPEYAMKTIKAAEEAGAERIVLADTN 182
+ ++ ++ + + G V AE D R +P + + A EAGA R ++DT
Sbjct: 129 RDKVEKLVRAASWA---GHKVSVGAE---DASRADPFFLAEIAHVAAEAGAIRFRISDTL 182
Query: 183 GGSLPSFIKEVVEKVKEEVKTPLGIHAHNDSELAVANSLIAFEAGVVQIQGTINGYGERC 242
G P E+V +V P+ H HND +A ANSL A AG + T+NG GER
Sbjct: 183 GVLDPFAAHELVGRVVTRCPLPVEFHGHNDLGMATANSLAAARAGASHLSVTVNGLGERA 242
Query: 243 GNANLISIIPALELKYGVEVVGKERLRKLKELAHFVAELANMEIPRNQPYVGDSAFAHKG 302
GNA L + ALE V +L L EL VA + + +P VG+ F H+
Sbjct: 243 GNAALEEVAAALEAAGRATGVALGQLCALSEL---VARASGRPLSPQKPIVGEGVFTHEC 299
Query: 303 GVHVSAVLKNPRTYEHID--PELVGNRRKVVVSELSGRSNLIYKAKELGIELEERDIKRI 360
G+HV ++K+ TYE D PE G ++ + + S + L E G+ + + +
Sbjct: 300 GIHVDGLMKDRATYESADLRPERFGRSHRIAIGKHSSAAGLARALAEAGLPADAATLAAL 359
Query: 361 VEEIK 365
+ ++
Sbjct: 360 MPALR 364
>sp|P05345|NIFV_KLEPN HOMOCITRATE SYNTHASE >gi|479601|pir||S34848 homocitrate synthase
(EC 4.1.3.21) - Klebsiella pneumoniae
>gi|43881|emb|CAA31119.1| (X12600) nifV gene product (AA
1 - 381) [Klebsiella pneumoniae]
Length = 381
Score = 131 bits (325), Expect = 3e-29
Identities = 108/361 (29%), Positives = 166/361 (45%), Gaps = 13/361 (3%)
Query: 6 RVELYDTTLRDGSQMEGISFSLEDKLKITEKLDEFGIHYIEGGWPGSNPKDIQYFKAVRD 65
RV + DTTLRDG Q G++F +K+ I E L GI +E G P ++I + VR
Sbjct: 3 RVLINDTTLRDGEQSPGVAFRTSEKVAIAEALYAAGITAMEVGTPAMGDEEIARIQLVRR 62
Query: 66 LPLENAKIAAFGSTRRPRLRPEEDPNLNALVESEAPIATIFGKSWDLHVTEALRTTLENN 125
L +A + + +R D ++ V+ P + K + E L LE
Sbjct: 63 -QLPDATLMTWCRMNALEIRQSADLGID-WVDISIPASD---KLRQYKLREPLAVLLER- 116
Query: 126 IQMIIDSIEYLRDHGMVVFYDAEHFFDGYRENPEYAMKTIKAAEEAGAERIVLADTNGGS 185
+ M I L G+ V E D R + + + A+ A A R+ ADT G
Sbjct: 117 LAMFIHLAHTL---GLKVCIGCE---DASRASGQTLRAIAEVAQNAPAARLRYADTVGLL 170
Query: 186 LPSFIKEVVEKVKEEVKTPLGIHAHNDSELAVANSLIAFEAGVVQIQGTINGYGERCGNA 245
P + +++ + +HAHND +A AN+L A AG + T+ G GER GNA
Sbjct: 171 DPFTTAAQISALRDVWSGEIEMHAHNDLGMATANTLAAVSAGATSVNTTVLGLGERAGNA 230
Query: 246 NLISIIPALELKYGVEVVGKERLRKLKELAHFVAELANMEIPRNQPYVGDSAFAHKGGVH 305
AL L+ + V L L VAE A I QP VG+ F H+ GVH
Sbjct: 231 AAWKP-SALGLERCLGVETGVHFSALPALCQRVAEAAQRAIDPQQPLVGELVFTHESGVH 289
Query: 306 VSAVLKNPRTYEHIDPELVGNRRKVVVSELSGRSNLIYKAKELGIELEERDIKRIVEEIK 365
V+A+L++ +Y+ I P L+G ++V+ + SGR + ++G L I +++ I+
Sbjct: 290 VAALLRDSESYQSIAPSLMGRSYRLVLGKHSGRQAVNGVFDQMGYHLNAAQINQLLPAIR 349
Query: 366 K 366
+
Sbjct: 350 R 350
>pir||S37297 nifV protein - Klebsiella pneumoniae >gi|149345|gb|AAA25157.1|
(M17350) nifV-encoded protein [Klebsiella pneumoniae]
Length = 381
Score = 130 bits (324), Expect = 3e-29
Identities = 108/361 (29%), Positives = 166/361 (45%), Gaps = 13/361 (3%)
Query: 6 RVELYDTTLRDGSQMEGISFSLEDKLKITEKLDEFGIHYIEGGWPGSNPKDIQYFKAVRD 65
RV + DTTLRDG Q G++F +K+ I E L GI +E G P ++I + VR
Sbjct: 3 RVLINDTTLRDGEQSPGVAFRTSEKVAIAEALYAAGITAMEVGTPAMGDEEIARIQLVRR 62
Query: 66 LPLENAKIAAFGSTRRPRLRPEEDPNLNALVESEAPIATIFGKSWDLHVTEALRTTLENN 125
L +A + + +R D ++ V+ P + K + E L LE
Sbjct: 63 -QLPDATLMTWCRMNALEIRQSADLGID-WVDISIPASD---KLPQYKLREPLAVLLER- 116
Query: 126 IQMIIDSIEYLRDHGMVVFYDAEHFFDGYRENPEYAMKTIKAAEEAGAERIVLADTNGGS 185
+ M I L G+ V E D R + + + A+ A A R+ ADT G
Sbjct: 117 LAMFIHLAHTL---GLKVCIGCE---DASRASGQTLRAIAEVAQNAPAARLRYADTVGLL 170
Query: 186 LPSFIKEVVEKVKEEVKTPLGIHAHNDSELAVANSLIAFEAGVVQIQGTINGYGERCGNA 245
P + +++ + +HAHND +A AN+L A AG + T+ G GER GNA
Sbjct: 171 DPFTTAAQISALRDVWSGEIEMHAHNDLGMATANTLAAVSAGATSVNTTVLGLGERAGNA 230
Query: 246 NLISIIPALELKYGVEVVGKERLRKLKELAHFVAELANMEIPRNQPYVGDSAFAHKGGVH 305
AL L+ + V L L VAE A I QP VG+ F H+ GVH
Sbjct: 231 AAWKP-SALGLERCLGVETGVHFSALPALCQRVAEAAQRAIDPQQPLVGELVFTHESGVH 289
Query: 306 VSAVLKNPRTYEHIDPELVGNRRKVVVSELSGRSNLIYKAKELGIELEERDIKRIVEEIK 365
V+A+L++ +Y+ I P L+G ++V+ + SGR + ++G L I +++ I+
Sbjct: 290 VAALLRDSESYQSIAPSLMGRSYRLVLGKHSGRQAVNGVFDQMGYHLNAAQINQLLPAIR 349
Query: 366 K 366
+
Sbjct: 350 R 350
>gb|AAF66618.1|AF142777_1 (AF142777) homocitrate synthase [Neurospora crassa]
Length = 270
Score = 130 bits (324), Expect = 3e-29
Identities = 77/236 (32%), Positives = 123/236 (51%), Gaps = 4/236 (1%)
Query: 133 IEYLRDHGMVVFYDAEHFFDGYRENPEYAMKTIKAAEEAGAERIVLADTNGGSLPSFIKE 192
IEY++ G+ V + +E D +R + + +A ++ G R+ +ADT G + P + +
Sbjct: 2 IEYVKSKGLEVRFSSE---DSFRSDLVDLLSLYRAVDKVGVHRVGIADTVGCASPRQVYD 58
Query: 193 VVEKVKEEVKTPLGIHAHNDSELAVANSLIAFEAGVVQIQGTINGYGERCGNANLISIIP 252
+V ++ V + H H+D+ A+AN+ A EAG I ++ G GER G L ++
Sbjct: 59 LVRTLRGVVSCDIETHFHDDTGCAIANAYCALEAGATHIDTSVLGIGERNGITPLGGLMA 118
Query: 253 ALELKYGVEVVGKERLRKLKELAHFVAELANMEIPRNQPYVGDSAFAHKGGVHVSAVLKN 312
+ + V K +L KLKEL VAE + P N P G AF HK G+H A+L N
Sbjct: 119 RMIVTSPDYVKSKYKLHKLKELEDLVAEAVEINTPFNNPITGFCAFTHKAGIHAKAILNN 178
Query: 313 PRTYEHIDPELVGNRRKV-VVSELSGRSNLIYKAKELGIELEERDIKRIVEEIKKL 367
P TYE ++P G R V S L+G + + + +LG+E+ + +K +IK L
Sbjct: 179 PSTYEILNPADFGLTRYVHFASRLTGWNAVKTRVGQLGLEMTDDQVKECTAKIKAL 234
>sp|P23122|NIFV_AZOCH HOMOCITRATE SYNTHASE >gi|280010|pir||C43706 nifV protein -
Azotobacter chroococcum >gi|142389|gb|AAA22161.1|
(M60090) homocitrate synthase [Azotobacter chroococcum]
Length = 382
Score = 120 bits (299), Expect = 3e-26
Identities = 92/355 (25%), Positives = 167/355 (46%), Gaps = 16/355 (4%)
Query: 11 DTTLRDGSQMEGISFSLEDKLKITEKLDEFGIHYIEGGWPGSNPKDIQYFKAVRDLPLEN 70
DTTLRDG Q G++F+ ++K+ I L E G+ +E G P ++ + +A+ L L +
Sbjct: 8 DTTLRDGEQSAGVAFNADEKIAIRRALAELGVPELEIGIPSMGEEEREVMRAIAGLGLSS 67
Query: 71 AKIAAFGSTRRPRLRPEEDPNLNALVESEAPIATIFGKSWDLHVTEALRTTLENNIQMII 130
+A D +L+A + + + DL + L + + +
Sbjct: 68 RLLAWCRLC---------DFDLSAARSTGVTMVDLSLPISDLMLRHKLNRDRDWALGEVA 118
Query: 131 DSIEYLRDHGMVVFYDAEHFFDGYRENPEYAMKTIKAAEEAGAERIVLADTNGGSLPSFI 190
+ R G+ V E D R + ++ ++ + A +A ADT G P +
Sbjct: 119 RLVSEARMAGLEVCLGCE---DASRADQDFIVR-VGAVAQAARPPPAFADTVGVMEPFGM 174
Query: 191 KEVVEKVKEEVKTPLGIHAHNDSELAVANSLIAFEAGVVQIQGTINGYGERCGNANLISI 250
+ +++ + L +HAH+D LA AN+L A G I T+NG GER NA L
Sbjct: 175 LDRFRFLRQRLDVELEVHAHDDFGLATANTLAAVMGGATHINTTVNGLGERAANAALEEC 234
Query: 251 IPALELKYGVEVVGKERLRKLKELAHFVAELANMEIPRNQPYVGDSAFAHKGGVHVSAVL 310
+ AL+ +G++ G + R + ++ V + + P + ++ F H+ G+HV +L
Sbjct: 235 VLALKNLHGID-TGID-TRGIPAISALVERASGRQWPGRRAWLA-PVFTHEAGIHVDGLL 291
Query: 311 KNPRTYEHIDPELVGNRRKVVVSELSGRSNLIYKAKELGIELEERDIKRIVEEIK 365
K+ R YE ++P+ +G +V+ + SG + +ELGIEL + + ++ I+
Sbjct: 292 KHRRNYEGLNPDELGRSHSLVLGKHSGAHMVRNSYRELGIELADWQSQALLGRIR 346
>emb|CAA91564.1| (Z67750) putative protein [Saccharomyces cerevisiae]
>gi|1903292|emb|CAA98756.1| (Z74229) ORF YDL182w
[Saccharomyces cerevisiae]
Length = 254
Score = 118 bits (293), Expect = 1e-25
Identities = 65/197 (32%), Positives = 105/197 (52%), Gaps = 1/197 (0%)
Query: 172 GAERIVLADTNGGSLPSFIKEVVEKVKEEVKTPLGIHAHNDSELAVANSLIAFEAGVVQI 231
G R+ +ADT G + P + E++ +K V + H HND+ A+AN+ A E G I
Sbjct: 2 GVNRVGIADTVGCANPRQVYELIRTLKSVVSCDIECHFHNDTGCAIANAYTALEGGARLI 61
Query: 232 QGTINGYGERCGNANLISIIPALELKYGVEVVGKERLRKLKELAHFVAELANMEIPRNQP 291
++ G GER G L ++ + + V K +L K++++ + VA+ + IP N P
Sbjct: 62 DVSVLGIGERNGITPLGGLMARMIVAAPDYVKSKYKLHKIRDIENLVADAVEVNIPFNNP 121
Query: 292 YVGDSAFAHKGGVHVSAVLKNPRTYEHIDPELVGNRRKV-VVSELSGRSNLIYKAKELGI 350
G AF HK G+H A+L NP TYE +DP G +R + + L+G + + + +L +
Sbjct: 122 ITGFCAFTHKAGIHAKAILANPSTYEILDPHDFGMKRYIHFANRLTGWNAIKARVDQLNL 181
Query: 351 ELEERDIKRIVEEIKKL 367
L + IK + +IKKL
Sbjct: 182 NLTDDQIKEVTAKIKKL 198
>pir||C83494 probable 2-isopropylmalate synthase PA1217 [imported] - Pseudomonas
aeruginosa (strain PAO1)
>gi|9947145|gb|AAG04606.1|AE004551_10 (AE004551)
probable 2-isopropylmalate synthase [Pseudomonas
aeruginosa]
Length = 455
Score = 113 bits (279), Expect = 6e-24
Identities = 87/325 (26%), Positives = 149/325 (45%), Gaps = 22/325 (6%)
Query: 7 VELYDTTLRDGSQMEGISFSLEDKLKITEKLDEFGIHYIEGGWPGSNPKDIQYFKAVRDL 66
+ + D TLR+G Q SF +++ ++ G+ IE G P + + + +AV +
Sbjct: 2 IRVIDCTLREGCQARQCSFDSAQSVQLAREIAALGVDMIECGHPRISADERERVRAV--V 59
Query: 67 PLENAKIAAFGSTRRPRLRPEEDPNLNALVESEAPIATIFGKSWDLHV-TEALRTTLENN 125
+ + A RR +++A++E+ A +F + + T+ E
Sbjct: 60 AAVSTPVLAHARARRE--------DIDAVLETGAQWVGLFASINAISLETKFKGMNREEV 111
Query: 126 IQMIIDSIEYLRDHGMVVFYDAEHFFDGYRENPEYAMKTIKAAEEAGAERIVLADTNGGS 185
+++ D+I Y R+ G+ V E D R + + I A +AGA+RI AD+ G
Sbjct: 112 LELFHDAIRYARERGLRVRATVE---DAARTSVSDLVSMIATARDAGADRICFADSVGIL 168
Query: 186 LPSFIKEVVEKVKEEVKTPL-GIHAHNDSELAVANSLIAFEAGVVQIQGTINGYGERCGN 244
LP +V+ ++ E + H HND LA+ N+L A +AGV + NG GER G
Sbjct: 169 LPDETFDVLSLLRHEFPDVVFEYHVHNDRGLALGNTLAAIQAGVQWHSASCNGIGERAGI 228
Query: 245 ANLISIIPALELKYGVEVVGKERLRKLKELAHFVAELANMEIPRN--QPYVGDSAFAHKG 302
+ ++ L K+ + + + + EL A+ I R+ P VG++AF H
Sbjct: 229 TDTFQLLTLLHTKFAADRFNLKNVLAVSELVE-----AHSRIKRSPMHPVVGENAFVHVA 283
Query: 303 GVHVSAVLKNPRTYEHIDPELVGNR 327
+H A+ +N Y DPEL+ R
Sbjct: 284 RLHQLAMQENQDAYSAFDPELINGR 308
>sp|P70728|NIFV_AZOBR HOMOCITRATE SYNTHASE >gi|1597740|gb|AAC46178.1| (U26427) nifV
[Azospirillum brasilense]
Length = 376
Score = 106 bits (261), Expect = 8e-22
Identities = 88/303 (29%), Positives = 143/303 (47%), Gaps = 24/303 (7%)
Query: 11 DTTLRDGSQMEGISFSLEDKLKITEKLDEFGIHYIEGGWPGSNPKDIQYFKAVRDLPLEN 70
DT RDG Q G++F+L++K+ I + LDE G+ +E G P ++ + +AV L L+
Sbjct: 9 DTHARDGEQTAGVAFTLDEKIAIAQALDEAGVAELEIGIPAMGREERERIRAVASLGLK- 67
Query: 71 AKIAAFGSTRRPRLRPEEDPNLNALVESEAPIATIFGKSWDLHVTEALRTTLENNIQMII 130
A++ + D +L A + AP ++ D+H+T+ L + ++ I
Sbjct: 68 ARLMVWCRM--------HDTDLKARSTAVAPSLSV--PVSDIHITKKLNGSRAWALREIE 117
Query: 131 DSIEYLRDHGMVVFYDAEHFFDGYRENPEYAMKTIKAAEEAGAERIVLADTNGGSLPSFI 190
++ RDHG+ V E D R + ++ I AA A R ADT G L F
Sbjct: 118 RKVKTARDHGLEVSLGGE---DSSRADMDF---LIAAATVAQRPRFRFADTL-GVLDPFQ 170
Query: 191 KEVVEKVKEEVKTPLGIHAHNDSELAVANSLIAFEA---GVVQIQGTINGYGERCGNANL 247
+ +G HAH LA A + + A G + T+NG GER GNA L
Sbjct: 171 HARLHLTAAATDPEIGYHAHT-PRLANATAWVTLAAVLGGATHVNTTVNGLGERAGNAPL 229
Query: 248 ISIIPALELKYGVEVVGKERLRKLKELAHFVAELANMEIPRNQPYVGDSAFAHKGGVHVS 307
++ +L++ YG + G + R L ++ V +N + N+ V D+ F H+ G+HV
Sbjct: 230 EEVVVSLKVLYGQD-CGVD-TRALGAISDLVERASNRPVAVNKSIVRDAVFTHEAGIHVD 287
Query: 308 AVL 310
+L
Sbjct: 288 GLL 290
>sp|Q44290|NIFV_ANASP HOMOCITRATE SYNTHASE >gi|1487879|emb|CAA68174.1| (X99902)
homocitrate synthase [Anabaena sp.]
Length = 379
Score = 105 bits (260), Expect = 1e-21
Identities = 94/368 (25%), Positives = 166/368 (44%), Gaps = 32/368 (8%)
Query: 6 RVELYDTTLRDGSQMEGISFSLEDKLKITEKLDEFGIHYIEGGWPGSNPKDIQYFKAVRD 65
+V + DTTLRDG Q G+ F+LE+K+ I + LD G+ +E G P ++++ A+ +
Sbjct: 3 KVLINDTTLRDGEQAAGVVFTLEEKVAIAKFLDTIGVPELEVGIPAMGEEEMRAICAISN 62
Query: 66 LPLENAKIAAFGSTRRPRLRPEEDPNLNALVESEAPIATIFGK---SWDLHVTEALRTTL 122
L L+ A + A+ ++ + V P++ + K W + + + R
Sbjct: 63 LGLK-ANLLAWNRAVISDIKASVACGMER-VHIAIPVSDVKAKFHGQWRVSLPKTQRL-- 118
Query: 123 ENNIQMIIDSIEYLRDHGMVVFYDAEHFFDGYRENPEYAMKTIKAAEEAGAERIVLADTN 182
+ D G+ V E D R + + + A+E GA R DT
Sbjct: 119 ----------YHFAVDQGLWVAVGGE---DSSRADENFLLDVALYAQEWGASRFRFCDTV 165
Query: 183 GGSLPSFIKEVVEKVKEEVKTPLGIHAHNDSELAVANSLIAFEAGVVQIQGTINGYGERC 242
G P V+ + + P+ +H HND +A N+L +AG + T+ G GER
Sbjct: 166 GVLDPFTTYGKVKLLVSALTIPVEVHTHNDFGMATLNALAGIKAGASSVNTTVIGLGERA 225
Query: 243 GNANLISIIPALELKYGVEV-VGKERLRKLKELAHFVAELANMEIPRNQ----PYVGDSA 297
GNA L ++ A++ YGV++ + RL +L +L A + + R P + +
Sbjct: 226 GNAALEEVVMAIKRIYGVDMGIDTPRLLELSQLV-AAAPVLMSHLGRRSLVKIPLLTNQV 284
Query: 298 FAHKGGVHVSAVLKNPRTYEHIDPELVGNRRKVVVSELSGRSNLIYKAKELGIELEERDI 357
F H V + P + H+ VGN R +VV + SGR ++ ++ GI L +
Sbjct: 285 FMHM----VYCKILIPMNHSHL-KRSVGNAR-LVVGKHSGRHSVSNLLEQHGIFLNPEET 338
Query: 358 KRIVEEIK 365
+ +++ ++
Sbjct: 339 QSVLDAVR 346
>sp|Q00853|NIVA_CLOPA HOMOCITRATE SYNTHASE, ALPHA SUBUNIT >gi|98609|pir||B39403 probable
homocitrate synthase (EC 4.1.3.21) NifV omega chain -
Clostridium pasteurianum >gi|144879|gb|AAA23268.1|
(M68878) nitrogen fixation protein [Clostridium
pasteurianum]
Length = 269
Score = 101 bits (250), Expect = 2e-20
Identities = 70/261 (26%), Positives = 124/261 (46%), Gaps = 22/261 (8%)
Query: 7 VELYDTTLRDGSQMEGISFSLEDKLKITEKLDEFGIHYIEGGWPGSNPKDIQYFKAVRDL 66
+ + DTTLRDG Q GI+ S++DK++I + + E G+H IE G P D
Sbjct: 3 INIVDTTLRDGEQKAGIALSVQDKVEIAKIISEMGVHQIEAGIPAMGG----------DE 52
Query: 67 PLENAKIAAFG-STRRPRLRPEEDPNLNALVESEAPIATIFGKSWDLHVTEALRTTLENN 125
+ +KIAA G ++ +++ +E I I DL + +T LE +
Sbjct: 53 KISVSKIAALGLPSKIAAWNRMSTKDIDTSIECGVDIVHISSPVSDLQI----KTKLEKD 108
Query: 126 IQMIIDSIE----YLRDHGMVVFYDAEHFFDGYRENPEYAMKTIKAAEEAGAERIVLADT 181
+ + ++++ Y + V E D R + + ++ + G +R+ ADT
Sbjct: 109 RKWVAENLKRTVIYALEKDCEVTVGLE---DSSRADLNFLIQLCEMIFALGVKRVRYADT 165
Query: 182 NGGSLPSFIKEVVEKVKEEVKTPLGIHAHNDSELAVANSLIAFEAGVVQIQGTINGYGER 241
G P + ++K++++V + IH HND +A++NS AF+AG TI G GER
Sbjct: 166 VGIMEPKELYSQIKKIRDKVPIDIEIHVHNDFGMAISNSFAAFKAGAKFADCTITGMGER 225
Query: 242 CGNANLISIIPALELKYGVEV 262
GN + + + ++ G ++
Sbjct: 226 AGNCDFLKFVKVIQELTGEKI 246
>pir||B70567 probable mhpE protein - Mycobacterium tuberculosis (strain H37RV)
>gi|2104392|emb|CAB08693.1| (Z95390) mhpE [Mycobacterium
tuberculosis]
Length = 336
Score = 87.0 bits (212), Expect = 5e-16
Identities = 73/273 (26%), Positives = 120/273 (43%), Gaps = 44/273 (16%)
Query: 11 DTTLRDGSQMEGISFSLEDKLKITEKLDEFGIHYIE-------GGWPGSNP---KDIQYF 60
DTT+RDGS ++ +D +I LD GI YIE G P D +YF
Sbjct: 14 DTTVRDGSYAVNFQYTDDDVRRIVGDLDAAGIPYIEIGHGVTIGAAAAQGPAAHTDEEYF 73
Query: 61 KAVRDLPLENAKIAAFGSTRRPRLRPEEDPNLNALVESEAPIATIFGKSWDL--HVTEAL 118
+A R + + NA++ A +V + A I T+ DL + L
Sbjct: 74 RAARSV-VRNARLGA------------------VIVPALARIETV-----DLAGDYLDFL 109
Query: 119 R-TTLENNIQMIIDSIEYLRDHGMVVFYD--AEHFFDGYRENPEYAMKTIKAAEEAGAER 175
R + ++++ +E + G+ V H F+ P+ K A + G
Sbjct: 110 RICVIATEFELVMPFVERAQSKGLEVSIQLVKSHLFE-----PDVLAAAGKRARDVGVRI 164
Query: 176 IVLADTNGGSLPSFIKEVVEKVKEEVKTPLGIHAHNDSELAVANSLIAFEAGVVQIQGTI 235
+ + DT G LP + VE ++ +G H HN+ +AVAN+L AF+AG + GT+
Sbjct: 165 VYVVDTTGTFLPEDARRYVEALRGASDVSVGFHGHNNLAMAVANTLEAFDAGADFLDGTL 224
Query: 236 NGYGERCGNANLISIIPALELKYGVEVVGKERL 268
G+G GN + ++ AL+ + + V +R+
Sbjct: 225 MGFGRGAGNCQIECLVAALQRRGHLAAVDLDRI 257
>sp|O31046|LEU1_STRCO 2-ISOPROPYLMALATE SYNTHASE (ALPHA-ISOPROPYLMALATE SYNTHASE)
(ALPHA-IPM SYNTHETASE) >gi|2582531|gb|AAB82586.1|
(AF026444) 2-isopropylmalate synthase [Streptomyces
coelicolor]
Length = 573
Score = 86.6 bits (211), Expect = 6e-16
Identities = 120/551 (21%), Positives = 217/551 (38%), Gaps = 73/551 (13%)
Query: 12 TTLRDGSQMEGISFSLEDKLKITEKLDEFGIHYIEGGWPGSNPKDIQYFKAVRDLP---L 68
T LRDG+Q S K + + L + G IE G+P S D + +++ + P
Sbjct: 42 TDLRDGNQALIDPMSPVRKRAMFDLLVKMGYKVIEVGFPASGQTDFDFVRSIIEEPGAIP 101
Query: 69 ENAKIAAFGSTRRPRLRPEEDPNLNALVESEAPIATIFGKSWDLHVTEALRTTLENNIQM 128
++ I+ R + + + +L + +F + + R + ++ Q+
Sbjct: 102 DDVTISVLTQAREDLI----ERTVESLKGARRATVHLFNATAPVFRRVVFRGSRDDIKQI 157
Query: 129 IIDSIEYLRDHGMVVFYDAEHFFDGYRENPE--------YAMKTIKAAEEA-----GAER 175
+D + ++ + F GY+ +PE +A++ +A + G E
Sbjct: 158 AVDGTRLVMEYAEKLLGPETEF--GYQYSPEIFTDTELDFALEVCEAVMDTYQPGPGREI 215
Query: 176 IV-LADTNGGSLPSFIKEVVE----KVKEEVKTPLGIHAHNDSELAVANSLIAFEAGVVQ 230
I+ L T S PS + E + L +H HND AVA + +A AG +
Sbjct: 216 ILNLPATVERSTPSTHADRFEWMGRNLSRREHVCLSVHPHNDRGTAVAAAELALMAGADR 275
Query: 231 IQGTINGYGERCGNANLISIIPALELKYGVEVVGKERLRKLKELAHFVAELANMEIPRNQ 290
I+G + G GER GN +L+++ L + V + + E+ ME+
Sbjct: 276 IEGCLFGQGERTGNVDLVTLGMNL---FSQGVDPQIDFSDIDEIRRTWEYCNQMEVHPRH 332
Query: 291 PYVGDSAFAHKGGVHVSAVLKN--------------------PRTYEHIDPELVGNRRKV 330
PYVGD + G H A+ K Y IDP+ VG +
Sbjct: 333 PYVGDLVYTSFSGSHQDAIKKGFDAMEADAAARGVTVDDIEWAVPYLPIDPKDVGRSYEA 392
Query: 331 V--VSELSGRSNLIYKAK-ELGIELEERDIKRIVEEIKKLEFEGYHFEAAEASLELLIER 387
V V+ SG+ + Y K + ++L +R+ E KL E E + + +
Sbjct: 393 VIRVNSQSGKGGIAYVLKNDHSLDLP----RRMQIEFSKLIQAKTDAEGGEITPTAIWDV 448
Query: 388 LRGRYKPFFELERARVITEIFQGQPP-----ISEANVVVRVNSRRVHTTAEGNGPVNALD 442
+ Y P + R+ ++ GQ + V V+ GNGP++A
Sbjct: 449 FQDEYLPNPDNPWGRI--QVANGQTTTDRDGVDTLTVDATVDGAETTLVGSGNGPISAFF 506
Query: 443 LALRKALTKFYPELKEIKLVDYKVRVLGSEKGTAAKVRVLVQTSDGKKTWGTVGASTNII 502
AL+ +++L+DY+ + +G +A+ ++ + G K +G N
Sbjct: 507 HALQGVGI-------DVRLLDYQEHTM--SEGASAQAASYIECAIGDKVLWGIGIDANTT 557
Query: 503 EASLNAIMESM 513
ASL A++ ++
Sbjct: 558 RASLKAVVSAV 568
>sp|O59736|LEU1_SCHPO 2-ISOPROPYLMALATE SYNTHASE (ALPHA-ISOPROPYLMALATE SYNTHASE)
(ALPHA-IPM SYNTHETASE) >gi|7489938|pir||T40500
2-isopropylmalate synthase - fission yeast
(Schizosaccharomyces pombe) >gi|3560136|emb|CAA20723.1|
(AL031534) 2-isopropylmalate synthase.
[Schizosaccharomyces pombe]
Length = 584
Score = 83.9 bits (204), Expect = 4e-15
Identities = 121/553 (21%), Positives = 217/553 (38%), Gaps = 78/553 (14%)
Query: 12 TTLRDGSQMEGISFSLEDKLKITEKLDEFGIHYIEGGWPGSNPKDIQYFKAVRDLP---L 68
T LRDG+Q + ++KL+ + L G IE G+P ++ D + + + + P
Sbjct: 50 TDLRDGNQALPDPMNGQEKLRYFKLLCSIGFKEIEVGFPSASQTDFAFVRHLIETPGLIP 109
Query: 69 ENAKIAAFGSTRRPRLRPEEDPNLNALVESEAPIATIFGKSWDLHVTEALRTTLENNIQM 128
++ I+A +R P + + AL ++ ++ L R + + + +
Sbjct: 110 DDVTISALTPSREPLILR----TIEALRGAKNATVHLYNACSPLFREVVFRNSKQETLDL 165
Query: 129 IIDSIEYL----------RDHGMVVFYDAEHFFDGYRENPEYAMKTIKAAE----EAGAE 174
I + + ++ Y E F D P++A++ +A + + A+
Sbjct: 166 AIKGSKIVTAATKNALESKETNWGFEYSPETFSD---TEPDFALEVCEAVKGMWKPSAAQ 222
Query: 175 RIV--LADTNGGSLPSFIKEVVE----KVKEEVKTPLGIHAHNDSELAVANSLIAFEAGV 228
I+ L T S P+ +++E + E K + +H HND AVA + + AG
Sbjct: 223 PIIFNLPATVEMSTPNTYADLIEYFSTNISEREKVCVSLHPHNDRGTAVAAAELGQLAGG 282
Query: 229 VQIQGTINGYGERCGNANLISIIPALELKYGVEVVGKERLRKLKELAHFVAELANMEIPR 288
+I+G + G GER GN +L+++ L Y V KL E+ + + +
Sbjct: 283 DRIEGCLFGNGERTGNVDLVTLAFNL---YTQGVSPNLDFSKLDEIIRITEDCNKINVHP 339
Query: 289 NQPYVGDSAFAHKGGVHVSAVLKNPRTYEH--------------IDPELVGNRRKVV--V 332
PY G+ F G H A+ K + Y+ +DP V + + V
Sbjct: 340 RHPYAGNLVFTAFSGSHQDAISKGLKAYDERKAVDPVWKVPYLPLDPHDVNSEYAAIIRV 399
Query: 333 SELSGRSNLIYKAK-ELGIELEERDIKRIVEEIKKLEFEGYHFEAAEA-SLELLIERLRG 390
+ SG+ + Y K G++L ++EF + ++ EL I +
Sbjct: 400 NSQSGKGGVAYLLKTNCGLDL---------PRALQVEFGSIVKDYSDTKGKELSIGEISD 450
Query: 391 RYKPFFELE---RARVITEIFQGQPPISEA-NVVVRVNSRRVHTTAE------GNGPVNA 440
+ + LE R V P S+ VV + + T + GNGP++A
Sbjct: 451 LFYTTYYLEFPGRFSVNDYTLSSNGPQSKCIKCVVDIKGEKKDTPSRVVIEGVGNGPLSA 510
Query: 441 LDLALRKALTKFYPELKEIKLVDYKVRVLGSEKGTAAKVRVLVQTSDGKKTWGTVGASTN 500
L ALR+ + + Y +GS G A V + + WG VG +
Sbjct: 511 LVDALRRQFNISF------DIGQYSEHAIGSGNGVKAASYVEI-IFNNTSFWG-VGIDAD 562
Query: 501 IIEASLNAIMESM 513
+ A L A+M +
Sbjct: 563 VTSAGLKAVMSGV 575
>gi|6324225 alpha-isopropylmalate synthase (2-Isopropylmalate Synthase); Leu4p
[Saccharomyces cerevisiae]
>gi|126192|sp|P06208|LEU1_YEAST 2-ISOPROPYLMALATE
SYNTHASE (ALPHA-ISOPROPYLMALATE SYNTHASE) (ALPHA-IPM
SYNTHETASE) >gi|82873|pir||A23872 2-isopropylmalate
synthase (EC 4.1.3.12) - yeast (Saccharomyces
cerevisiae) >gi|171841|gb|AAA34743.1| (M12893)
alpha-isopropylmalate synthase (EC 4.1.3.12) long form
[Saccharomyces cerevisiae] >gi|929849|emb|CAA90522.1|
(Z50161) 2-Isopropylmalate Synthase [Saccharomyces
cerevisiae] >gi|1302020|emb|CAA95980.1| (Z71380) ORF
YNL104c [Saccharomyces cerevisiae]
Length = 619
Score = 76.9 bits (186), Expect = 5e-13
Identities = 123/561 (21%), Positives = 221/561 (38%), Gaps = 94/561 (16%)
Query: 12 TTLRDGSQMEGISFSLEDKLKITEKLDEFGIHYIEGGWPGSNPKDIQYFK-AVRDLPLEN 70
T LRDG+Q S+E K + KL G IE +P ++ D + + AV + P ++
Sbjct: 66 TDLRDGNQSLPDPMSVEQKKEYFHKLVNIGFKEIEVSFPSASQTDFDFTRYAVENAP-DD 124
Query: 71 AKIAAFGSTRRPRLRPEEDPNLNALVESEAPIATIFGKSWDLHVTEALRTTLENNIQMII 130
I +R ++ + A +A I T S D+ + E I +
Sbjct: 125 VSIQCLVQSREHLIKRTVEALTGA---KKATIHTYLATS-DMFREIVFNMSREEAISKAV 180
Query: 131 DSIEYLRD------HGMVVFYDAEHFFDGYRENP-EYAMK---TIKAAEEAGAERIVLAD 180
++ + +R + E + + + P E+A++ +K A E E ++ +
Sbjct: 181 EATKLVRKLTKDDPSQQATRWSYEFSPECFSDTPGEFAVEICEAVKKAWEPTEENPIIFN 240
Query: 181 ---TNGGSLPSFIKEVVE----KVKEEVKTPLGIHAHNDSELAVANSLIAFEAGVVQIQG 233
T + P+ + +E + E K + H HND VA + + AG +++G
Sbjct: 241 LPATVEVASPNVYADQIEYFATHITEREKVCISTHCHNDRGCGVAATELGMLAGADRVEG 300
Query: 234 TINGYGERCGNANLISIIPALELKYGVEVVGKERLRKLKELAHFVAELANMEIPRNQPYV 293
+ G GER GN +L+++ + Y V L + V + + + PY
Sbjct: 301 CLFGNGERTGNVDLVTVAMNM---YTQGVSPNLDFSDLTSVLDVVERCNKIPVSQRAPYG 357
Query: 294 GDSAFAHKGGVHVSAV-----LKNPR----------TYEHIDPELVGNRRKVV--VSELS 336
GD G H A+ L+N + Y +DP+ +G + V V+ S
Sbjct: 358 GDLVVCAFSGSHQDAIKKGFNLQNKKRAQGETQWRIPYLPLDPKDIGRDYEAVIRVNSQS 417
Query: 337 GRSNLIYK-AKELGIELEE------------------RDIKRIVEEIKKLEFEGYHFEAA 377
G+ + + LG++L R++K +EI KL E Y++
Sbjct: 418 GKGGAAWVILRSLGLDLPRNMQIEFSSAVQDHADSLGRELKS--DEISKLFKEAYNYNDE 475
Query: 378 EASLELLIERLRGRYKPFFELERARVITEIFQGQPPISEANVVVRVNSRRVHTTAEGNGP 437
+ L+ + +E+ +F GQ V+V + V GNGP
Sbjct: 476 QYQAISLVN---------YNVEKFGTERRVFTGQ---------VKVGDQIVDIEGTGNGP 517
Query: 438 VNALDLALRKALTKFYPELKEIKLVDYKVRVLGSEKGTAAKVRVLV---QTSDGKKT--W 492
+++L AL L + +Y LGS T A + + + +D +K W
Sbjct: 518 ISSLVDALSNLLN------VRFAVANYTEHSLGSGSSTQAASYIHLSYRRNADNEKAYKW 571
Query: 493 GTVGASTNIIEASLNAIMESM 513
G VG S ++ ++S+ AI ++
Sbjct: 572 G-VGVSEDVGDSSVRAIFATI 591
>gb|AAA34744.1| (M12893) alpha-isopropylmalate synthase (EC 4.1.3.12) short form
[Saccharomyces cerevisiae]
Length = 589
Score = 76.9 bits (186), Expect = 5e-13
Identities = 123/561 (21%), Positives = 221/561 (38%), Gaps = 94/561 (16%)
Query: 12 TTLRDGSQMEGISFSLEDKLKITEKLDEFGIHYIEGGWPGSNPKDIQYFK-AVRDLPLEN 70
T LRDG+Q S+E K + KL G IE +P ++ D + + AV + P ++
Sbjct: 36 TDLRDGNQSLPDPMSVEQKKEYFHKLVNIGFKEIEVSFPSASQTDFDFTRYAVENAP-DD 94
Query: 71 AKIAAFGSTRRPRLRPEEDPNLNALVESEAPIATIFGKSWDLHVTEALRTTLENNIQMII 130
I +R ++ + A +A I T S D+ + E I +
Sbjct: 95 VSIQCLVQSREHLIKRTVEALTGA---KKATIHTYLATS-DMFREIVFNMSREEAISKAV 150
Query: 131 DSIEYLRD------HGMVVFYDAEHFFDGYRENP-EYAMK---TIKAAEEAGAERIVLAD 180
++ + +R + E + + + P E+A++ +K A E E ++ +
Sbjct: 151 EATKLVRKLTKDDPSQQATRWSYEFSPECFSDTPGEFAVEICEAVKKAWEPTEENPIIFN 210
Query: 181 ---TNGGSLPSFIKEVVE----KVKEEVKTPLGIHAHNDSELAVANSLIAFEAGVVQIQG 233
T + P+ + +E + E K + H HND VA + + AG +++G
Sbjct: 211 LPATVEVASPNVYADQIEYFATHITEREKVCISTHCHNDRGCGVAATELGMLAGADRVEG 270
Query: 234 TINGYGERCGNANLISIIPALELKYGVEVVGKERLRKLKELAHFVAELANMEIPRNQPYV 293
+ G GER GN +L+++ + Y V L + V + + + PY
Sbjct: 271 CLFGNGERTGNVDLVTVAMNM---YTQGVSPNLDFSDLTSVLDVVERCNKIPVSQRAPYG 327
Query: 294 GDSAFAHKGGVHVSAV-----LKNPR----------TYEHIDPELVGNRRKVV--VSELS 336
GD G H A+ L+N + Y +DP+ +G + V V+ S
Sbjct: 328 GDLVVCAFSGSHQDAIKKGFNLQNKKRAQGETQWRIPYLPLDPKDIGRDYEAVIRVNSQS 387
Query: 337 GRSNLIYK-AKELGIELEE------------------RDIKRIVEEIKKLEFEGYHFEAA 377
G+ + + LG++L R++K +EI KL E Y++
Sbjct: 388 GKGGAAWVILRSLGLDLPRNMQIEFSSAVQDHADSLGRELKS--DEISKLFKEAYNYNDE 445
Query: 378 EASLELLIERLRGRYKPFFELERARVITEIFQGQPPISEANVVVRVNSRRVHTTAEGNGP 437
+ L+ + +E+ +F GQ V+V + V GNGP
Sbjct: 446 QYQAISLVN---------YNVEKFGTERRVFTGQ---------VKVGDQIVDIEGTGNGP 487
Query: 438 VNALDLALRKALTKFYPELKEIKLVDYKVRVLGSEKGTAAKVRVLV---QTSDGKKT--W 492
+++L AL L + +Y LGS T A + + + +D +K W
Sbjct: 488 ISSLVDALSNLLN------VRFAVANYTEHSLGSGSSTQAASYIHLSYRRNADNEKAYKW 541
Query: 493 GTVGASTNIIEASLNAIMESM 513
G VG S ++ ++S+ AI ++
Sbjct: 542 G-VGVSEDVGDSSVRAIFATI 561
>sp|Q9X7L2|LEU1_RHIME 2-ISOPROPYLMALATE SYNTHASE (ALPHA-ISOPROPYLMALATE SYNTHASE)
(ALPHA-IPM SYNTHETASE)
Length = 569
Score = 76.1 bits (184), Expect = 9e-13
Identities = 122/544 (22%), Positives = 214/544 (38%), Gaps = 77/544 (14%)
Query: 14 LRDGSQMEGISFSLEDKLKITEKLDEFGIHYIEGGWPGSNPKDIQYFKAVRDLPLENAKI 73
LRDG+Q + K ++ L + G IE G+P ++ D + + +E +
Sbjct: 48 LRDGNQALVDPMGHDRKARMFHLLLDMGFKEIEIGFPSASQTDYDFARWC----VEEGNV 103
Query: 74 AAFGSTR-----RPRLRPEEDPNLNALVESEAPIATIFGKSWDLHVTEALRTTLENNIQM 128
+ S + RP L AL + PI + + +L + Q+
Sbjct: 104 SEDVSLQVLVQCRPELIAR---TFEALEGAHRPIVHFYNSTSELQRRVVFGKDVAGIKQI 160
Query: 129 IIDSIEYLRDH------GMVVFYDAEHFFDGYRENP-EYAMKTIKAAEEAGAERIV--LA 179
D+ + + D G Y E F E E I+ +++ L
Sbjct: 161 ATDAAKMITDMAAKAGGGYRFEYSPESFTGTELEVALEICNAVIEIVRPTADNKLIINLP 220
Query: 180 DTNGGSLPSFIKEVVE----KVKEEVKTPLGIHAHNDSELAVANSLIAFEAGVVQIQGTI 235
T + P+ + +E + + +H HND +A + + AG +++GT+
Sbjct: 221 STVEMATPNIYADQIEWMCRNLDNRENLIVSLHPHNDRGTGIAATELGLMAGADRVEGTL 280
Query: 236 NGYGERCGNANLISIIPALELKYGVEVVGKERLRKLKELAHFVAELANMEIPRNQPYVGD 295
G GER GN +++++ + + + + ++KE+ + + M IP PYVG+
Sbjct: 281 FGNGERTGNVDVVTLALNMFTQGVDPKLDCSDIERIKEVYEYSNQ---MVIPERHPYVGE 337
Query: 296 SAFAHKGGVHVSAVLKNPRT------------YEHIDPELVGNRRKVV--VSELSGRSNL 341
+ G H A+ K + Y IDP VG + + ++ SG+ +
Sbjct: 338 LVYTAFSGSHQDAINKGMKAIKQANKPTWEVPYLPIDPRDVGRSYEAIIRINSQSGKGGI 397
Query: 342 IYKAKE---------LGIELEERDIKRIV-EEIKKLEFEGYHFEAAEASLELLIERLR-- 389
Y +E L IE E +++RI EE K+L + H E+ +E R++
Sbjct: 398 AYILQEDYGINLPRNLQIEFRE-EVQRITDEEGKELPSKRIHQRFIESYVEQPGARIKFV 456
Query: 390 -GRYKPFFELERARVITEIFQGQPPISEANVVVRVNSRRVHTTAEGNGPVNALDLALRKA 448
P E + RV+ A + +R++ +G GP++ AL
Sbjct: 457 DHHTYPAGEHKGLRVVA-----------AEITDGGETRQIE--GKGTGPIDGFINALSIY 503
Query: 449 LTKFYPELKEIKLVDYKVRVLGSEKGTAAKVRVLVQTSDGKKTWGTVGASTNIIEASLNA 508
L E+ + DY L AA V V+ G K +G VG +TNI+ ASL A
Sbjct: 504 LG------IELSVADYSEHSLQHGSNAAAIAYVEVEYPGG-KLFG-VGINTNIVAASLEA 555
Query: 509 IMES 512
I+ +
Sbjct: 556 IVSA 559
>emb|CAB69749.1| (AL137166) 2-ispoprylmalate synthase [Streptomyces coelicolor
A3(2)]
Length = 499
Score = 76.1 bits (184), Expect = 9e-13
Identities = 80/337 (23%), Positives = 137/337 (39%), Gaps = 46/337 (13%)
Query: 205 LGIHAHNDSELAVANSLIAFEAGVVQIQGTINGYGERCGNANLISIIPALELKYGVEVVG 264
L +H HND AVA + +A AG +I+G + G GER GN +L+++ L + V
Sbjct: 176 LSVHPHNDRGTAVAAAELALMAGADRIEGCLFGQGERTGNVDLVTLGMNL---FSQGVDP 232
Query: 265 KERLRKLKELAHFVAELANMEIPRNQPYVGDSAFAHKGGVHVSAVLKN------------ 312
+ + E+ ME+ PYVGD + G H A+ K
Sbjct: 233 QIDFSDIDEIRRTWEYCNQMEVHPRHPYVGDLVYTSFSGSHQDAIKKGFDAMEADAAARG 292
Query: 313 --------PRTYEHIDPELVGNRRKVV--VSELSGRSNLIYKAK-ELGIELEERDIKRIV 361
Y IDP+ VG + V V+ SG+ + Y K + ++L +R+
Sbjct: 293 VTVDDIEWAVPYLPIDPKDVGRSYEAVIRVNSQSGKGGIAYVLKNDHSLDLP----RRMQ 348
Query: 362 EEIKKLEFEGYHFEAAEASLELLIERLRGRYKPFFELERARVITEIFQGQPP-----ISE 416
E KL E E + + + + Y P + R+ ++ GQ +
Sbjct: 349 IEFSKLIQAKTDAEGGEITPTAIWDVFQDEYLPNPDNPWGRI--QVANGQTTTDRDGVDT 406
Query: 417 ANVVVRVNSRRVHTTAEGNGPVNALDLALRKALTKFYPELKEIKLVDYKVRVLGSEKGTA 476
V V+ GNGP++A AL+ +++L+DY+ + +G +
Sbjct: 407 LTVDATVDGAETTLVGSGNGPISAFFHALQGVGI-------DVRLLDYQEHTM--SEGAS 457
Query: 477 AKVRVLVQTSDGKKTWGTVGASTNIIEASLNAIMESM 513
A+ ++ + G K +G N ASL A++ ++
Sbjct: 458 AQAASYIECAIGDKVLWGIGIDANTTRASLKAVVSAV 494
>emb|CAB39977.1| (AJ132004) 2-isopropylmalate synthase [Sinorhizobium meliloti]
Length = 569
Score = 75.7 bits (183), Expect = 1e-12
Identities = 122/544 (22%), Positives = 214/544 (38%), Gaps = 77/544 (14%)
Query: 14 LRDGSQMEGISFSLEDKLKITEKLDEFGIHYIEGGWPGSNPKDIQYFKAVRDLPLENAKI 73
LRDG+Q + K ++ L + G IE G+P ++ D + + +E +
Sbjct: 48 LRDGNQALVDPMGHDRKARMFHLLLDMGFKEIEIGFPSASQTDYDFARWC----VEEGNV 103
Query: 74 AAFGSTR-----RPRLRPEEDPNLNALVESEAPIATIFGKSWDLHVTEALRTTLENNIQM 128
+ S + RP L AL + PI + + +L + Q+
Sbjct: 104 SEDVSLQVLVQCRPELIAR---TFEALEGAHRPIVHFYNSTSELQRRVVFGKDVAGIKQI 160
Query: 129 IIDSIEYLRDH------GMVVFYDAEHFFDGYRENP-EYAMKTIKAAEEAGAERIV--LA 179
D+ + + D G Y E F E E I+ +++ L
Sbjct: 161 ATDAAKMITDMAAKAGGGYRFEYSPESFTGTELEVALEICNAVIEIVRPTADNKLIINLP 220
Query: 180 DTNGGSLPSFIKEVVE----KVKEEVKTPLGIHAHNDSELAVANSLIAFEAGVVQIQGTI 235
T + P+ + +E + + +H HND +A + + AG +++GT+
Sbjct: 221 STVEMATPNIYADQIEWMCRNLDNRENLIVSLHPHNDRGTGIAATDLGLMAGADRVEGTL 280
Query: 236 NGYGERCGNANLISIIPALELKYGVEVVGKERLRKLKELAHFVAELANMEIPRNQPYVGD 295
G GER GN +++++ + + + + ++KE+ + + M IP PYVG+
Sbjct: 281 FGNGERTGNVDVVTLALNMFTQGVDPKLDCSDIERIKEVYEYSNQ---MVIPERHPYVGE 337
Query: 296 SAFAHKGGVHVSAVLKNPRT------------YEHIDPELVGNRRKVV--VSELSGRSNL 341
+ G H A+ K + Y IDP VG + + ++ SG+ +
Sbjct: 338 LVYTAFSGSHQDAINKGMKAIKQANKPTWEVPYLPIDPRDVGRSYEAIIRINSQSGKGGI 397
Query: 342 IYKAKE---------LGIELEERDIKRIV-EEIKKLEFEGYHFEAAEASLELLIERLR-- 389
Y +E L IE E +++RI EE K+L + H E+ +E R++
Sbjct: 398 AYILQEDYGINLPRNLQIEFRE-EVQRITDEEGKELPSKRIHQRFIESYVEQPGARIKFV 456
Query: 390 -GRYKPFFELERARVITEIFQGQPPISEANVVVRVNSRRVHTTAEGNGPVNALDLALRKA 448
P E + RV+ A + +R++ +G GP++ AL
Sbjct: 457 DHHTYPAGEHKGLRVVA-----------AEITDGGETRQIE--GKGTGPIDGFINALSIY 503
Query: 449 LTKFYPELKEIKLVDYKVRVLGSEKGTAAKVRVLVQTSDGKKTWGTVGASTNIIEASLNA 508
L E+ + DY L AA V V+ G K +G VG +TNI+ ASL A
Sbjct: 504 LG------IELSVADYSEHSLQHGSNAAAIAYVEVEYPGG-KLFG-VGINTNIVAASLEA 555
Query: 509 IMES 512
I+ +
Sbjct: 556 IVSA 559
>sp|Q51983|CMTG_PSEPU 4-HYDROXY-2-OXOVALERATE ALDOLASE (HOA) >gi|1263190|gb|AAB62295.1|
(U24215) 4-hydroxy-2-oxovalerate aldolase [Pseudomonas
putida] >gi|11138232|dbj|BAB17781.1| (AB042508)
4-hydroxy-2-oxovalerate aldolase [Pseudomonas putida]
>gi|1588772|prf||2209341M 4-hydroxy-2-oxovalerate
aldolase [Pseudomonas putida]
Length = 350
Score = 75.7 bits (183), Expect = 1e-12
Identities = 85/294 (28%), Positives = 126/294 (41%), Gaps = 50/294 (17%)
Query: 4 KRRVELYDTTLRDGSQMEGISFSLEDKLKITEKLDEFGIHYIE----GGWPGSN------ 53
++++ + D TLRDG +SL D +I LDE G+ IE G GS+
Sbjct: 5 RKKIYVSDVTLRDGMHAVRHQYSLADAERIARALDEAGVDSIEVAHGDGLQGSSFNYGFG 64
Query: 54 -PKDIQYFKAVRDLPLENAKIAAFGSTRRPRLRPEED-PNLNALVESEAPIATIFGKSWD 111
D+++ + V + AKIA P + D N NA S +AT
Sbjct: 65 AHTDLEWIERVA-ATVRRAKIATL---LLPGIGTVHDLKNANAAGASVVRVAT------- 113
Query: 112 LHVTEALRTTLENNIQMIIDSIEYLRDHGM--VVFYDAEHFFDGYRENPEYAMKTIKAAE 169
H TEA + IEY R GM V F H P K E
Sbjct: 114 -HCTEA---------DISQQHIEYARKLGMDTVGFLMMSHM-----TTPTALAVEAKKME 158
Query: 170 EAGAERIVLADTNGGSLPSFIKEVVEKVKE--EVKTPLGIHAHNDSELAVANSLIAFEAG 227
GA+ I + D+ G I + + +K+ + T G+HAH++ L VANS++A E G
Sbjct: 159 SYGAQCIYVVDSGGAMNMYDIADRFKALKDVLDPSTQTGMHAHHNLSLGVANSIVALEYG 218
Query: 228 VVQIQGTINGYGERCGNANL---ISIIPALELKYGVEV-----VGKERLRKLKE 273
+I ++ G G GNA L I+ + + LK+G +V +E +R L+E
Sbjct: 219 CDRIDASLTGMGAGAGNAPLEVFIAAVDRMGLKHGCDVRKLIDAAEEIVRPLQE 272
>sp|Q00852|NIVO_CLOPA HOMOCITRATE SYNTHASE, OMEGA SUBUNIT >gi|98608|pir||A39403 probable
homocitrate synthase (EC 4.1.3.21) NifV alpha chain -
Clostridium pasteurianum >gi|144878|gb|AAA23267.1|
(M68878) nitrogen fixation protein [Clostridium
pasteurianum]
Length = 352
Score = 75.3 bits (182), Expect = 2e-12
Identities = 50/195 (25%), Positives = 95/195 (48%), Gaps = 12/195 (6%)
Query: 176 IVLADTNGGSLPSFIKEV--VEKVKEEVKTPLGIHAHNDSELAVANSLIAFEAG--VVQI 231
IV N S FI E ++ +K + + A N +A A + AF G ++
Sbjct: 139 IVCLRINNLSKLDFIDEDFRIKDLKSKFNVLVDFCASNKYNMATAIIINAFLNGSDIITT 198
Query: 232 QGTINGYGERCGNANLISIIPALELKYGVEVVGKERLRKLKELAHFVAELANMEIPRNQP 291
+ N Y A + +I AL+ +E+ G L+ + +L ++ + + +P
Sbjct: 199 EFNSNDY------AAMEEVIIALKSIRNIEIRGD--LKLISKLTRIYEKITSERVYSMKP 250
Query: 292 YVGDSAFAHKGGVHVSAVLKNPRTYEHIDPELVGNRRKVVVSELSGRSNLIYKAKELGIE 351
+G+ F ++ G+H + KNP+ YE +PEL+G RK+ + + SG++ L+ K KEL +
Sbjct: 251 ILGEDIFKYESGIHADGIAKNPKNYEPFNPELIGTNRKLYIGKHSGKAALVVKFKELNLN 310
Query: 352 LEERDIKRIVEEIKK 366
D+ +++I++
Sbjct: 311 CNNIDMNLFLQDIRE 325
>emb|CAA19166.1| (AL023596) 2-isopropylmalate synthase [Mycobacterium leprae]
Length = 342
Score = 73.4 bits (177), Expect = 6e-12
Identities = 85/336 (25%), Positives = 134/336 (39%), Gaps = 46/336 (13%)
Query: 205 LGIHAHNDSELAVANSLIAFEAGVVQIQGTINGYGERCGNANLISIIPALELKYGVEVVG 264
L +H HND AVA + + + AG +I+G + G GER GN L+++ L L + V
Sbjct: 20 LSLHPHNDRGTAVAAAELGYHAGADRIEGCLFGNGERTGNVCLVTL--GLNL-FSRGVDP 76
Query: 265 KERLRKLKELAHFVAELANMEIPRNQPYVGDSAFAHKGGVHVSAVLKN------------ 312
+ + E+ V + + PY GD + G H A+ K
Sbjct: 77 QIDFSNIDEIRRTVEYCNKLRVHERHPYGGDLVYTAFSGSHQDAINKGLDQMKIDADAAD 136
Query: 313 --------PRTYEHIDPELVGNRRKVV--VSELSGRSNLIYKAK-ELGIELEER---DIK 358
Y IDP VG + V V+ SG+ + Y K + G+EL R +
Sbjct: 137 SDVDDILWQVPYLPIDPRDVGRTYEAVIRVNSQSGKGGVAYIMKADHGLELPRRLQIEFS 196
Query: 359 RIVEEIKKLEFEGYHFEAAEASLELLIERLRGRYKPFFELERARVITEIFQGQPPISEAN 418
R +++I E EG E E L P LER + + +
Sbjct: 197 RAIQKIS--EGEGGEITPTEMWDVFFEEYL----SPVQPLERIKQRVNAAEEDGGSTSIA 250
Query: 419 VVVRVNSRRVHTTAEGNGPVNALDLALRKALTKFYPELKEIKLVDYKVRVLGSEKGTAAK 478
V++N + GNGP+ A AL ++ ++DY + + G A+
Sbjct: 251 ATVKINGEETEISGVGNGPLAAFIDALGHVGL-------QVAVLDYSEHAMNA--GDDAQ 301
Query: 479 VRVLVQTS-DGKKTWGTVGASTNIIEASLNAIMESM 513
V+ S G WG VG + +I ASL A++ ++
Sbjct: 302 AAAYVEASVHGHTAWG-VGIAPSITTASLRAVVSAV 336
>dbj|BAA90528.1| (AB029822) 2-phosphinomethylmalic acid synthase [Streptomyces
hygroscopicus]
Length = 440
Score = 72.6 bits (175), Expect = 1e-11
Identities = 76/281 (27%), Positives = 126/281 (44%), Gaps = 27/281 (9%)
Query: 128 MIIDSIEYLRDHGMVVFYDAEHFFDGYRENPEYAM----KTIKAAEEAGAE---RIVLAD 180
M +D++ DHG+ H D R +P++ + +K AE AE R + D
Sbjct: 157 MYLDAVTMALDHGI---RPRVHLEDTTRSSPDFVRALVEEVLKTAERYPAELQPRFRVCD 213
Query: 181 TNGGSLPSFIKEVVEKVKEEVKTPLG---------IHAHNDSELAVANSLIAFEAGVVQI 231
T G LP + + ++ G +H HND+ L VAN L A G I
Sbjct: 214 TLGIGLPYDDVSLPRSIPRWIRLLRGFGLSPSQIELHPHNDTWLVVANCLAAIREGCGVI 273
Query: 232 QGTINGYGERCGNANLISIIPALELKYGVEVVGKERLRKLKELAHFVAELANMEIPRNQP 291
GT G GER GNA L +++ L L G + L + +L + E + P
Sbjct: 274 SGTTLGTGERTGNAPLEAVMVHL-LGMGYWSGARVNLPAVNKLVE-LYEGIGAGPSQKYP 331
Query: 292 YVGDSAFAHKGGVHVSAVLKNPRTYEHID-PELVGNRRKVVVSELSGRSNLIYKA-KELG 349
+ G A+ + G+H + K Y + P L G V +++ SG++ L++ K LG
Sbjct: 332 FFGRDAYVTRAGIHADGLNKFWWMYAPFNAPLLTGRELDVALTKDSGQAGLLFVLNKRLG 391
Query: 350 IELEERDIKRIVEEIKKL--EFEGYHFEAAE-ASLELLIER 387
++LE+ D R+ E + + +++ A E + LE ++E+
Sbjct: 392 LQLEKGD-PRVAEVLAWMDRQWDAGRVSAVEWSELEPVVEK 431
>sp|P51020|MHPE_ECOLI 4-HYDROXY-2-OXOVALERATE ALDOLASE (HOA) >gi|7465763|pir||H64762
4-hydroxy-2-oxovalerate aldolase (EC 4.1.3.-) -
Escherichia coli >gi|1657548|gb|AAB18076.1| (U73857)
similar to P. put4-hydroxy-2-oxovalerate aldolaseida
[Escherichia coli] >gi|1665751|dbj|BAA13057.1| (D86239)
MhpF [Escherichia coli] >gi|1786548|gb|AAC73455.1|
(AE000142) 4-hydroxy-2-ketovalerate aldolase
[Escherichia coli K12]
Length = 337
Score = 71.8 bits (173), Expect = 2e-11
Identities = 77/266 (28%), Positives = 118/266 (43%), Gaps = 40/266 (15%)
Query: 5 RRVELYDTTLRDGSQMEGISFSLEDKLKITEKLDEFGIHYIE----GGWPGSN------- 53
+++ + D TLRDG +SLE+ +I + LD+ + IE G GS+
Sbjct: 4 KKLYISDVTLRDGMHAIRHQYSLENVRQIAKALDDARVDSIEVAHGDGLQGSSFNYGFGA 63
Query: 54 PKDIQYFKAVRDLPLENAKIAAFGSTRRPRLRPEEDPNLNALVESEAPIATIFGKSWDLH 113
D+++ +A D+ +++AKIA P + D L ++ A + + H
Sbjct: 64 HSDLEWIEAAADV-VKHAKIATL---LLPGIGTIHD--LKNAWQAGARVVRVA-----TH 112
Query: 114 VTEALRTTLENNIQMIIDSIEYLRDHGM--VVFYDAEHFFDGYRENPEYAMKTIKAAEEA 171
TEA + I+Y R+ GM V F H PE K K E
Sbjct: 113 CTEA---------DVSAQHIQYARELGMDTVGFLMMSHM-----TTPENLAKQAKLMEGY 158
Query: 172 GAERIVLADTNGGSLPSFIKEVVEKVKEEVK--TPLGIHAHNDSELAVANSLIAFEAGVV 229
GA I + D+ G S I++ +K E+K T G+HAH++ L VANS+ A E G
Sbjct: 159 GATCIYVVDSGGAMNMSDIRDRFRALKAELKPETQTGMHAHHNLSLGVANSIAAVEEGCD 218
Query: 230 QIQGTINGYGERCGNANLISIIPALE 255
+I ++ G G GNA L I A +
Sbjct: 219 RIDASLAGMGAGAGNAPLEVFIAAAD 244
>sp|P51014|BPHF_PSES1 4-HYDROXY-2-OXOVALERATE ALDOLASE (HOA) >gi|1073055|pir||C55511
4-hydroxy-2-oxovalerate aldolase - Pseudomonas sp.
(strain KKS102) >gi|425214|dbj|BAA03893.1| (D16407)
4-hydroxy-2-oxovalerate aldolase [Pseudomonas sp.]
Length = 352
Score = 70.2 bits (169), Expect = 5e-11
Identities = 76/266 (28%), Positives = 115/266 (42%), Gaps = 40/266 (15%)
Query: 5 RRVELYDTTLRDGSQMEGISFSLEDKLKITEKLDEFGIHYIE----GGWPGSN------- 53
+++ + D TLRDGS +S+E I ++LDE + IE G GS+
Sbjct: 4 KKIYISDVTLRDGSHAIRHQYSVEQVRTIAKELDEAKVDSIEVAHGSGLQGSSFNYGFGA 63
Query: 54 PKDIQYFKAVRDLPLENAKIAAFGSTRRPRLRPEEDPNLNALVESEAPIATIFGKSWDLH 113
D+++ +AV + +++AKIA P + D L A ++ A I + H
Sbjct: 64 HTDLEWIEAVASV-VKHAKIATL---LLPGIGTIHD--LKAAYDAGARIVRVA-----TH 112
Query: 114 VTEALRTTLENNIQMIIDSIEYLRDHGM--VVFYDAEHFFDGYRENPEYAMKTIKAAEEA 171
TEA + IEY R GM V F H P+ + K E
Sbjct: 113 CTEA---------DISKQHIEYARHLGMEAVGFLMMSHM-----STPQGLAQQAKLMESY 158
Query: 172 GAERIVLADTNGGSLPSFIKEVVEKVKEEVK--TPLGIHAHNDSELAVANSLIAFEAGVV 229
GA + D+ G ++ K+ +K T GIHAH++ L VANS++A E G
Sbjct: 159 GATCCYVVDSGGALSMDDVRMRFRAFKDVLKPETETGIHAHHNLSLGVANSIVAIEEGCD 218
Query: 230 QIQGTINGYGERCGNANLISIIPALE 255
++ ++ G G GNA L I A E
Sbjct: 219 RVDASLAGMGAGAGNAPLEVFIAAAE 244
>dbj|BAA82884.1| (AB024335) 4-hydroxy-2-ketovalerate aldolase [Comamonas
testosteroni]
Length = 343
Score = 69.5 bits (167), Expect = 9e-11
Identities = 74/270 (27%), Positives = 117/270 (42%), Gaps = 40/270 (14%)
Query: 1 MLMKRRVELYDTTLRDGSQMEGISFSLEDKLKITEKLDEFGIHYIE----GGWPGSN--- 53
M +++ + D TLRDGS +S+E +I + LDE + IE G GS+
Sbjct: 1 MTQTKKIYISDVTLRDGSHAIRHQYSVEQARQIAQALDEARVDSIEVAHGDGLQGSSFNY 60
Query: 54 ----PKDIQYFKAVRDLPLENAKIAAFGSTRRPRLRPEEDPNLNALVESEAPIATIFGKS 109
D+++ +AV + +++AKI P + D L A E+ + +
Sbjct: 61 GFGAHTDLEWIEAVASV-VKHAKITTL---LLPGIGTVHD--LKAAYEAGVRVVRVA--- 111
Query: 110 WDLHVTEALRTTLENNIQMIIDSIEYLRDHGM--VVFYDAEHFFDGYRENPEYAMKTIKA 167
H TEA + IEY R GM V F H +P+ + K
Sbjct: 112 --THCTEA---------DVSRQHIEYARQLGMEAVGFLMMSHM-----TSPKALAEQAKL 155
Query: 168 AEEAGAERIVLADTNGGSLPSFIKEVVEKVKEEVK--TPLGIHAHNDSELAVANSLIAFE 225
E GA + D+ G + +++ K+ +K T G+HAH++ L VANS++A E
Sbjct: 156 MESYGATCCYVVDSGGALGMNDVRDRFRAFKDILKPETQTGMHAHHNLSLGVANSIVAVE 215
Query: 226 AGVVQIQGTINGYGERCGNANLISIIPALE 255
G ++ ++ G G GNA L I A E
Sbjct: 216 EGCDRVDASLAGMGAGAGNAPLEVFIAAAE 245
Database: ./suso.pep
Posted date: Jul 6, 2001 5:57 PM
Number of letters in database: 840,471
Number of sequences in database: 2977
Database: /banques/blast2/nr.pep
Posted date: Dec 14, 2000 12:46 PM
Number of letters in database: 188,266,275
Number of sequences in database: 595,510
Lambda K H
0.316 0.136 0.378
Gapped
Lambda K H
0.270 0.0470 0.230
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 186763641
Number of Sequences: 2977
Number of extensions: 7847855
Number of successful extensions: 23360
Number of sequences better than 1.0e-10: 109
Number of HSP's better than 0.0 without gapping: 30
Number of HSP's successfully gapped in prelim test: 79
Number of HSP's that attempted gapping in prelim test: 23022
Number of HSP's gapped (non-prelim): 124
length of query: 526
length of database: 189,106,746
effective HSP length: 60
effective length of query: 466
effective length of database: 153,197,526
effective search space: 71390047116
effective search space used: 71390047116
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 41 (21.6 bits)
S2: 167 (69.5 bits)