BLASTP 2.0.10 [Aug-26-1999]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= PAB0913 (PAB0913) DE:multidrug resistance protein
(410 letters)
Database: ./suso.pep; /banques/blast2/nr.pep
598,487 sequences; 189,106,746 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
pir||E75048 multidrug resistance protein PAB0913 - Pyrococcus ab... 797 0.0
pir||D71112 hypothetical protein PH0667 - Pyrococcus horikoshii ... 600 e-170
pir||G64494 quinolone resistance protein norA homolog - Methanoc... 129 8e-29
pir||F72384 conserved hypothetical protein - Thermotoga maritima... 124 2e-27
gb|AAD38864.1| (L09121) hypothetical protein [Thermus thermophilus] 97 3e-19
gb|AAG18975.1| (AE004998) multidrug resistance protein homolog; ... 97 4e-19
emb|CAA07482.1| (AJ007367) multi-drug resistance efflux pump [St... 97 4e-19
sp|P39843|BMR2_BACSU MULTIDRUG RESISTANCE PROTEIN 2 (MULTIDRUG-E... 96 7e-19
dbj|BAB06030.1| (AP001515) unknown conserved protein [Bacillus h... 96 1e-18
pir||D75094 transport protein, permease PAB0761 - Pyrococcus aby... 94 2e-18
pir||S74875 quinolone resistance protein norA - Synechocystis sp... 94 4e-18
gi|11498923 multidrug resistance protein [Archaeoglobus fulgidus... 94 4e-18
sp|P25744|YCEE_ECOLI HYPOTHETICAL 43.9 KDA PROTEIN IN MSYB-HTRB ... 92 1e-17
dbj|BAB05494.1| (AP001513) multidrug-efflux transporter [Bacillu... 91 2e-17
dbj|BAB04893.1| (AP001511) multidrug-efflux transporter [Bacillu... 90 3e-17
dbj|BAB06311.1| (AP001516) unknown conserved protein [Bacillus h... 90 4e-17
pir||E75042 transporter (major facilitator family) related PAB08... 90 5e-17
gb|AAA16158.1| (M80252) norA1199 protein [Staphylococcus aureus]... 89 7e-17
pir||H71070 hypothetical protein PH1260 - Pyrococcus horikoshii ... 89 9e-17
gi|4505527 organic cation transporter-like 2; Beckwith-Wiedemann... 88 2e-16
gb|AAC14725.1| (AF059663) tumor suppressing STF cDNA 5 [Homo sap... 88 2e-16
dbj|BAA32779.1| (AB012083) ITM [Homo sapiens] 88 2e-16
gi|11440671 organic cation transporter-like 2 [Homo sapiens] 88 2e-16
sp|P40760|YUXJ_BACSU HYPOTHETICAL 39.1 KD PROTEIN IN KAPD-PBPD I... 87 5e-16
sp|P21191|NORA_STAAU QUINOLONE RESISTANCE NORA PROTEIN >gi|97835... 86 6e-16
gb|AAB31949.1| (S74031) NorA {ISP794, quinolone resistance} [Sta... 86 6e-16
gb|AAB82727.1| (AF028738) imprinted multi-membrane spanning poly... 86 6e-16
gb|AAC17492.1| (AF030302) p45-BWR1A [Homo sapiens] 86 6e-16
gb|AAC23505.1| (AF070479) efflux transporter like protein [Homo ... 86 6e-16
gb|AAD10060.1| (AF113952) multidrug-efflux transporter [Campylob... 86 8e-16
pir||D81282 probable efflux protein Cj1375 [imported] - Campylob... 86 8e-16
gb|AAD09860.1| (AF090987) drug efflux protein TetA [Agrobacteriu... 85 1e-15
pir||D64464 hypothetical protein MJ1317 - Methanococcus jannasch... 85 2e-15
emb|CAC11303.1| (AL445063) conserved hypothetical protein [Therm... 84 2e-15
pir||B70065 antibiotic resistance protein homolog ywoG - Bacillu... 83 5e-15
dbj|BAA36484.1| (AB019536) NorA [Staphylococcus aureus] 83 7e-15
emb|CAA76069.1| (Y16103) tetracycline resistance efflux protein ... 81 2e-14
pir||B71247 hypothetical protein PH0233 - Pyrococcus horikoshii ... 81 3e-14
sp|P51564|TCR8_PASMU TETRACYCLINE RESISTANCE PROTEIN, CLASS H (T... 80 4e-14
pir||G71118 hypothetical protein PH0718 - Pyrococcus horikoshii ... 80 4e-14
pir||H75515 tetracycline-efflux transporter - Deinococcus radiod... 80 5e-14
gb|AAK40865.1| Multidrug resistance related protein [Sulfolobus ... 80 6e-14
emb|CAB57751.1| (Y18930) hypothetical protein [Sulfolobus solfat... 80 6e-14
pir||D83117 probable MFS transporter PA4233 [imported] - Pseudom... 79 8e-14
emb|CAA75663.1| (Y15510) tetracycline resistance efflux protein ... 79 1e-13
emb|CAC08220.1| (AJ245947) tetracycline resistance efflux protei... 79 1e-13
dbj|BAA32780.1| (AB012084) ITM [Mus musculus] >gi|11191803|emb|C... 78 1e-13
pir||B75211 multidrug resistance protein PAB0146 - Pyrococcus ab... 78 1e-13
gi|10957271 tetracycline antiporter protein [Salmonella typhi] >... 78 2e-13
gi|9507600 tetracycline resistance protein [Plasmid R100] >gi|13... 77 4e-13
pir||E71116 hypothetical protein PH0700 - Pyrococcus horikoshii ... 77 4e-13
pir||B81080 drug resistance translocase family protein NMB1461 [... 76 5e-13
pir||G75306 drug transport protein - Deinococcus radiodurans (st... 76 5e-13
pir||B75044 hypothetical protein PAB0885 - Pyrococcus abyssi (st... 76 7e-13
dbj|BAB06930.1| (AP001518) multidrug resistance protein [Bacillu... 76 7e-13
gb|AAB82728.1| (AF028739) multi-membrane spanning polyspecific t... 75 2e-12
gi|10955433 TetA protein [Escherichia coli] >gi|43701|emb|CAA238... 74 3e-12
sp|P33449|BMR1_BACSU MULTIDRUG RESISTANCE PROTEIN 1 (MULTIDRUG-E... 74 3e-12
gi|6679180 organic cationic transporter-like 2 [Mus musculus] >g... 74 4e-12
pir||A72413 conserved hypothetical protein - Thermotoga maritima... 73 6e-12
pir||C55220 msyB homolog, pbpD 5'-region - Bacillus subtilis (fr... 72 1e-11
pir||F72774 hypothetical protein APE0184 - Aeropyrum pernix (str... 72 1e-11
dbj|BAB13163.1| (AP001119) hypothetical protein [Buchnera sp. APS] 72 1e-11
pir||B72579 probable drug resistance protein APE1914 - Aeropyrum... 70 5e-11
gb|AAG20506.1| (AE005122) Vng2419c [Halobacterium sp. NRC-1] 69 9e-11
>pir||E75048 multidrug resistance protein PAB0913 - Pyrococcus abyssi (strain
Orsay) >gi|5458795|emb|CAB50282.1| (AJ248287) multidrug
resistance protein [Pyrococcus abyssi]
Length = 410
Score = 797 bits (2037), Expect = 0.0
Identities = 410/410 (100%), Positives = 410/410 (100%)
Query: 1 MRPRELAILQGLQEKSGKIRKITMRKNILMFAIGMFFADFAWGLGFPYLGVYMKLIGGTM 60
MRPRELAILQGLQEKSGKIRKITMRKNILMFAIGMFFADFAWGLGFPYLGVYMKLIGGTM
Sbjct: 1 MRPRELAILQGLQEKSGKIRKITMRKNILMFAIGMFFADFAWGLGFPYLGVYMKLIGGTM 60
Query: 61 FLVGLLSVVYNLTSTIFQYPFGYLSDKTGKRKPFIILGILASGTTYGLVALITSPILLLG 120
FLVGLLSVVYNLTSTIFQYPFGYLSDKTGKRKPFIILGILASGTTYGLVALITSPILLLG
Sbjct: 61 FLVGLLSVVYNLTSTIFQYPFGYLSDKTGKRKPFIILGILASGTTYGLVALITSPILLLG 120
Query: 121 LRAFQGALGASLAPAHSALISELSPRIGSMFGFFGFVENLGFMAGNFAGGYIVKTLGMKM 180
LRAFQGALGASLAPAHSALISELSPRIGSMFGFFGFVENLGFMAGNFAGGYIVKTLGMKM
Sbjct: 121 LRAFQGALGASLAPAHSALISELSPRIGSMFGFFGFVENLGFMAGNFAGGYIVKTLGMKM 180
Query: 181 MFIITSLVSLIGILFLLKIKERGRAKAGGDRLIIVKEGRESDRVELKEIAFKKLMKGRLG 240
MFIITSLVSLIGILFLLKIKERGRAKAGGDRLIIVKEGRESDRVELKEIAFKKLMKGRLG
Sbjct: 181 MFIITSLVSLIGILFLLKIKERGRAKAGGDRLIIVKEGRESDRVELKEIAFKKLMKGRLG 240
Query: 241 IFYVAVLLAMIASGAVYATVSVYFEEKFGEEFVGYLFGIDSLSAALSALIIGRLIDKYGE 300
IFYVAVLLAMIASGAVYATVSVYFEEKFGEEFVGYLFGIDSLSAALSALIIGRLIDKYGE
Sbjct: 241 IFYVAVLLAMIASGAVYATVSVYFEEKFGEEFVGYLFGIDSLSAALSALIIGRLIDKYGE 300
Query: 301 KLFFRLSLVGYIITFMGYALANSVIIMALISILSGLKWTMLTNSSSTYVARRVPTSERGQ 360
KLFFRLSLVGYIITFMGYALANSVIIMALISILSGLKWTMLTNSSSTYVARRVPTSERGQ
Sbjct: 301 KLFFRLSLVGYIITFMGYALANSVIIMALISILSGLKWTMLTNSSSTYVARRVPTSERGQ 360
Query: 361 GMGLLNTMMTLGWVIGPLIGGILADNFGFAVMLYSTVPILFLGFLLSFRI 410
GMGLLNTMMTLGWVIGPLIGGILADNFGFAVMLYSTVPILFLGFLLSFRI
Sbjct: 361 GMGLLNTMMTLGWVIGPLIGGILADNFGFAVMLYSTVPILFLGFLLSFRI 410
>pir||D71112 hypothetical protein PH0667 - Pyrococcus horikoshii
>gi|3257075|dbj|BAA29758.1| (AP000003) 413aa long
hypothetical protein [Pyrococcus horikoshii]
Length = 413
Score = 600 bits (1530), Expect = e-170
Identities = 290/409 (70%), Positives = 352/409 (85%)
Query: 1 MRPRELAILQGLQEKSGKIRKITMRKNILMFAIGMFFADFAWGLGFPYLGVYMKLIGGTM 60
M+ R+ ILQG++E++GK R+ T+++NI FAIGMFFA+ AWG+G+PYL VYMK+IGGTM
Sbjct: 4 MKTRKNTILQGIRERAGKARRNTLKRNITFFAIGMFFANLAWGIGYPYLTVYMKIIGGTM 63
Query: 61 FLVGLLSVVYNLTSTIFQYPFGYLSDKTGKRKPFIILGILASGTTYGLVALITSPILLLG 120
FLVGLLSV+YNLTS IFQYPFGYLSDK GKRKPFIILG+L SGTTY LV I++PILLL
Sbjct: 64 FLVGLLSVIYNLTSAIFQYPFGYLSDKIGKRKPFIILGVLFSGTTYVLVIFISTPILLLS 123
Query: 121 LRAFQGALGASLAPAHSALISELSPRIGSMFGFFGFVENLGFMAGNFAGGYIVKTLGMKM 180
LR QGALGAS APAHSALISELS R+GSMFGFF FVEN+GFM GNF GGYIVK +G+K
Sbjct: 124 LRGTQGALGASFAPAHSALISELSTRVGSMFGFFNFVENMGFMVGNFLGGYIVKKVGIKS 183
Query: 181 MFIITSLVSLIGILFLLKIKERGRAKAGGDRLIIVKEGRESDRVELKEIAFKKLMKGRLG 240
F+ TS+VSL+ ILFL ++KER R K + ++EGRES++VE+K AFK LMKG LG
Sbjct: 184 AFLATSIVSLVSILFLTQVKERERKKKNIGSFLPIREGRESEKVEMKSSAFKMLMKGELG 243
Query: 241 IFYVAVLLAMIASGAVYATVSVYFEEKFGEEFVGYLFGIDSLSAALSALIIGRLIDKYGE 300
FY++VLLAMIASG VYATV VYF+EKFGEEFVG+L GIDSL+AAL +L+IGRLIDKYGE
Sbjct: 244 AFYLSVLLAMIASGEVYATVPVYFQEKFGEEFVGFLLGIDSLAAALGSLLIGRLIDKYGE 303
Query: 301 KLFFRLSLVGYIITFMGYALANSVIIMALISILSGLKWTMLTNSSSTYVARRVPTSERGQ 360
K+F++L+++GYI+TF+GYA A ++IIMAL+S+LSG+KW M+T+S+STYVARRVP ERGQ
Sbjct: 304 KVFYKLAILGYILTFIGYAWATTIIIMALVSLLSGVKWAMITSSASTYVARRVPHRERGQ 363
Query: 361 GMGLLNTMMTLGWVIGPLIGGILADNFGFAVMLYSTVPILFLGFLLSFR 409
GMGLLNTMMTLGWVIGPLIGG++ADNFGF+VMLYST L + FLL+F+
Sbjct: 364 GMGLLNTMMTLGWVIGPLIGGLIADNFGFSVMLYSTTLPLIVSFLLAFK 412
>pir||G64494 quinolone resistance protein norA homolog - Methanococcus
jannaschii >gi|1592184|gb|AAB99579.1| (U67596)
multidrug-efflux transporter (bmr1) [Methanococcus
jannaschii]
Length = 386
Score = 129 bits (320), Expect = 8e-29
Identities = 98/399 (24%), Positives = 190/399 (47%), Gaps = 30/399 (7%)
Query: 24 MRKNILMFAIGMFFADFAWGLGFPYLGVYMKLIGGTMFLVGLLSVVYNLTSTIFQYPFGY 83
+ KN+ + I F G P + +Y + +G T +GL+ + L T+ Q P G
Sbjct: 4 LEKNVFVIWITTFTTMLGVGFIAPIMAIYAQTLGATNLEIGLIFGSFALARTVAQIPVGV 63
Query: 84 LSDKTGKRKPFIILGILASGTTYGLVALITSPILLLGLRAFQGALGASLAPAHSALISEL 143
LSD GK K FI+ G G + + +++ + L +R F G A + P + I+ +
Sbjct: 64 LSDIYGK-KFFIVCGTFFYGVSTLMYNFVSTVLGFLIVRIFTGIFSAFVTPVAGSYIAAI 122
Query: 144 SP--RIGSMFGFFGFVENLGFMAGNFAGGYIVKTLGMKMMFIITSLVSLI-GILFLLKIK 200
+P R+G G F LGF G F GG + G+KM F + ++ I+ +K++
Sbjct: 123 APKTRLGEYMGIFNSAITLGFGIGPFIGGILADMYGIKMPFYFCGFLGILAAIISYMKLE 182
Query: 201 ERGRAKAGGDRLIIVKEGRESDRVELKEI----AFKKLMKGRLGIFYVAVLLAMIASGAV 256
+ I+ + +E ++++K+I +F+ L ++ + ++ + +
Sbjct: 183 D-----------IVFNKNKE--KIDVKKISTLFSFEFLKNRNFSSSFIINVSNVMINAGI 229
Query: 257 YATVSVY-FEEKFGEEFVGYLFGIDSLSAALSALIIGRLIDKYGEKLFFRLSLVG-YIIT 314
YA +++Y VG++ + ++ AL G+L DK G + ++G +II+
Sbjct: 230 YAYLALYAINYNITISQVGFMIALTNILMALLQRSFGKLYDKLGNIMI----IIGIFIIS 285
Query: 315 FMGYALANSVIIMALISILS--GLKWTMLTNSSSTYVARRVPTSERGQGMGLLNTMMTLG 372
F Y L+ S + +++ L+ + ++ + ++++ + +PT +G+ MGL T + +G
Sbjct: 286 FGMYLLSTSTTFLTILASLTIIAVGSSISSTATTSLAVKDIPTHRKGEAMGLFTTSINIG 345
Query: 373 WVIGPLIGGILADNFGFAVML-YSTVPILFLGFLLSFRI 410
IG + G LAD G A M +S + + +G + RI
Sbjct: 346 MFIGAVSFGFLADILGIANMYKFSAIFSIVVGIISYLRI 384
>pir||F72384 conserved hypothetical protein - Thermotoga maritima (strain MSB8)
>gi|4980872|gb|AAD35455.1|AE001717_1 (AE001717)
conserved hypothetical protein [Thermotoga maritima]
Length = 369
Score = 124 bits (308), Expect = 2e-27
Identities = 92/361 (25%), Positives = 170/361 (46%), Gaps = 32/361 (8%)
Query: 53 MKLIGGTMFLVGLLSVVYNLTSTIFQYPFGYLSDKTGKRKPFIILGILASGTTYGLVALI 112
MK IG T+FL+GLLS + +T +G +SDK GKRK FIIL ++ + Y L A+I
Sbjct: 24 MKEIGATLFLIGLLSSLQGAMNTFSNVFWGRISDKIGKRKVFIILSLVLASAFYPLYAVI 83
Query: 113 TSPILLLGLRAFQGALGASLAPAHSALISELSPRIGSMFGFFGFVENLGFMAGNFAGGYI 172
P +L + PA AL S + ++ F + +LG + + G++
Sbjct: 84 DVPSAILIVSMIIAFFNGMYPPAAMAL-SSTAKKMSLGFSLYNSSNSLGMLLSRISIGFL 142
Query: 173 VKTLGMKMMFIITSLVSLIGILFLLKIKERGRAKAGGDRLIIVKEGRESDRVELKEIAF- 231
+ + +K+ F+ S+V + ++ L +KE +++ +E D F
Sbjct: 143 LMFMDLKLAFVFFSIVVAVSVIPALGLKEEK-----------IQKKKEED------FHFG 185
Query: 232 KKLMKGRLGIFYVAVLLAMIASGAVYATVSVYFEEKF--GEEFVGYLFGIDSLSAALSAL 289
+K+M+ + Y+ LL + + + ++VY E+F +G++ ++ L S
Sbjct: 186 RKVMEHGIWALYLGSLLRQMGTSGSMSLIAVYLNERFHYSASTIGFITAVNPLVQIPSHF 245
Query: 290 IIGRLIDKYGEKLFFRLSL-VGYIITFMGYALANSVIIMALISILSGLKWTMLTNSSSTY 348
+ G++++K K L + + ++ F+ N ++A + G + N S+ +
Sbjct: 246 LFGKMVEKVDPKFISVLGIFMSSLVPFLMMIPENWAPVLAYAFL--GASFGAFINGSNNF 303
Query: 349 VARRVPTSERGQGMGLLNTMMTLGWVIGPLIGGILAD--------NFGFAVMLYSTVPIL 400
+ RR +RG+ +GLL++ LG IGP + G+LA+ G AV+ V +L
Sbjct: 304 LGRRFHYLQRGRALGLLSSARFLGATIGPFLAGLLAEKSYSLMFSTLGLAVLSGGIVVLL 363
Query: 401 F 401
F
Sbjct: 364 F 364
>gb|AAD38864.1| (L09121) hypothetical protein [Thermus thermophilus]
Length = 385
Score = 97.1 bits (238), Expect = 3e-19
Identities = 98/394 (24%), Positives = 168/394 (41%), Gaps = 42/394 (10%)
Query: 39 DFAWGLGFPYLGVYMKLIGGTMFLVGLLSVVYNLTSTIFQYPFGYLSDKTGKRKPFIILG 98
D A + +P L +++ +G +GL+ V T+++F+ G LSD+ G+R+PF++LG
Sbjct: 2 DVASEMAYPLLPLFLASLGAGPGTIGLVEGVAEATASLFKVVGGRLSDRLGRRRPFLLLG 61
Query: 99 ILASGTTYGLVALITSPILLLGLRAFQGALGASLAPA-HSALISELSPR--IGSMFGFFG 155
L+AL SP +L L F G L A ALI+E +P+ +G +G
Sbjct: 62 YGLPALFRPLLALAQSPFHVL-LYRFLDRTGKGLRTAPRDALIAESAPKEALGRAYGLHR 120
Query: 156 FVENLGFMAGNFAGGYIVKTLGMKMMFIITSLVSLIGILFLLKIKERGRAKAGGDRLIIV 215
++ LG G F ++ LG + +F +++L +L+ L L ++E R +
Sbjct: 121 SLDTLGATLGPFLAFLLLPLLGFRGVFWLSALPALLAFLLLFAVRETPRPPS-------- 172
Query: 216 KEGRESDRVELKEIAFKKLMKGRLGIFYVAVLLAMIASGAVYATVSVYFEEKFGEEFVGY 275
L +A L G V+ L A+ S + + + E +E V
Sbjct: 173 ---------PLPPLALGHLSPGYRRFLLVSGLFALALSSNAFLLLRLK-ELGLSQEEVAL 222
Query: 276 LFGIDSLSAALSALIIGRLIDKYGEKLFFRLSLVGYIITFMGYALANSVIIMALISILSG 335
+ + +L AL A +G L D+ G Y + ++G+A A + L
Sbjct: 223 AYTLYNLLYALLAYPLGGLADRVGLGRMVATGFGLYALVYLGFAWARTAFWALGFLFLYA 282
Query: 336 LKWTMLTNSSSTYVARRVPTSERGQGMGLLNTMM-----------------TLGWVIGP- 377
L ++ Y+A VP + +GL +T++ +G ++ P
Sbjct: 283 LYSAAFEGANRAYLATLVPEEAKAGAIGLYHTVVGVLLLPAKAGAIGLYHTVVGVLLLPA 342
Query: 378 -LIGGILADNFGFAVMLYSTVPILFLGFLLSFRI 410
L+ G+L FG A + T L LG LL F +
Sbjct: 343 SLLFGLLWQAFG-AAAAFLTGAALALGALLLFLV 375
>gb|AAG18975.1| (AE004998) multidrug resistance protein homolog; YfmO2
[Halobacterium sp. NRC-1]
Length = 420
Score = 96.7 bits (237), Expect = 4e-19
Identities = 94/335 (28%), Positives = 143/335 (42%), Gaps = 32/335 (9%)
Query: 62 LVGLLSVVYNLTSTIFQYPFGYLSDKTGKRKPFIILGILASGTTYGLVALITSPILLLGL 121
L+G++ + ++ Q G LSD+TG RKPFI+ G++ G A ++ LLL L
Sbjct: 64 LIGIVLSTFGFLNSFLQPFTGRLSDRTGVRKPFILGGLVLLALASGAYAFVSDYRLLLVL 123
Query: 122 RAFQGALGASLAPAHSALISEL--SPRIGSMFGFFGFVENLGFMAGNFAGGYIVKTLGMK 179
RA QG A PA AL+SEL + GS FG F +GF G G +++
Sbjct: 124 RALQGIGAALTVPATVALVSELGTTETRGSNFGVFNTFRLIGFGFGPIIAGVVLEVFSFN 183
Query: 180 MMFIIT---SLVSLIGILFLLKIKERGRAKAGGDRLIIVKEGRESDRVELKEIAFKKLMK 236
F + +L S + + + + A AG D I V+ D L +
Sbjct: 184 AAFGVAAAGALTSFVLVELTVDEPDTDGADAGDDLSIAVR----GDDAVLDPVF------ 233
Query: 237 GRLGIFYVAVLLAMIASGAVYATVSVYFEEKFGEEFV--GYLFGIDSLSAALSALIIGRL 294
LGI VA+ + + A++AT+ K + + G FG +L+ + + IG
Sbjct: 234 -ALGIATVAMGICI----AMFATLEAKINGKLDQSSILFGAEFGAVTLANVMFQVPIGTA 288
Query: 295 IDKYGEKLFFRLSLVGYIITF-----MGYALANSVIIMALISILSGLKWTMLTNSSSTYV 349
D YG + F + G+II GYA + +I+A + G+ + S
Sbjct: 289 SDTYGRRPFI---IAGFIILIPATIAQGYAPTPATMILA--RFVQGIAVAAVFAPSLAVA 343
Query: 350 ARRVPTSERGQGMGLLNTMMTLGWVIGPLIGGILA 384
E G + +L LG IGPL G LA
Sbjct: 344 GDLAGAGESGSTLAVLTMGFGLGTAIGPLASGFLA 378
>emb|CAA07482.1| (AJ007367) multi-drug resistance efflux pump [Streptococcus
pneumoniae]
Length = 399
Score = 96.7 bits (237), Expect = 4e-19
Identities = 93/387 (24%), Positives = 173/387 (44%), Gaps = 25/387 (6%)
Query: 21 KITMRKNILMFAIGMFFADFAWGLGFPYLGVYMKLIG----GTMFLVGLLSVVYNLTSTI 76
+I + N+ + G F + L P++ ++++ +G F GL V +++ +
Sbjct: 3 EINWKDNLRIAWFGNFLTGASISLVVPFMPIFVENLGVGSQQVAFYAGLAISVSAISAAL 62
Query: 77 FQYPFGYLSDKTGKRKPFIILGILASGTTYGLVALITSPILLLGLRAFQGALGASLAPAH 136
F +G L+DK G RKP +I LA T G +A + + L+ LR G A P
Sbjct: 63 FSPIWGILADKYG-RKPMMIRAGLAMTITMGGLAFVPNIYWLIFLRLLNGVF-AGFVPNA 120
Query: 137 SALISELSPR--IGSMFGFFGFVENLGFMAGNFAGGYIVKTLGMKMMFIIT-SLVSLIGI 193
+ALI+ P+ GS G G + G F GG+I + G++ +F++ S + L I
Sbjct: 121 TALIASQVPKEKSGSALGTLSTGVVAGTLTGPFIGGFIAELFGIRTVFLLVGSFLFLAAI 180
Query: 194 LFLLKIKERGRAKAGGDRLIIVKEGRESDRVELKEIAFKKLMKGRLGIFYVAVLLAMIAS 253
L + IKE D + KE + + + L+ L +F + ++ A
Sbjct: 181 LTICFIKE--------DFQPVAKEKAIPTKELFTSVKYPYLL---LNLFLTSFVIQFSAQ 229
Query: 254 GAVYATVSVYFEEKFGEEFVGYLFGID----SLSAALSALIIGRLIDKYGEKLFFRLSLV 309
++ +++Y + E + ++ G+ S+ +SA ++G+L DK G ++
Sbjct: 230 -SIGPILALYVRDLGQTENLLFVSGLIVSSMGFSSMMSAGVMGKLGDKVGNHRLLVVAQF 288
Query: 310 GYIITFMGYALANSVIIMALISILSGLKWTMLTNSSSTYVARRVPTSERGQGMGLLNTMM 369
+I ++ A A+S + + L L GL L + +++ P + +
Sbjct: 289 YSVIIYLLCANASSPLQLGLYRFLFGLGTGALIPGVNALLSKMTPKAGISRVFAFNQVFF 348
Query: 370 TLGWVIGPLIGGILADNFGFAVMLYST 396
LG V+GP+ G +A FG+ + Y+T
Sbjct: 349 YLGGVVGPMAGSAVAGQFGYHAVFYAT 375
>sp|P39843|BMR2_BACSU MULTIDRUG RESISTANCE PROTEIN 2 (MULTIDRUG-EFFLUX TRANSPORTER 2)
>gi|2119909|pir||I39792 multidrug-efflux transporter blt
- Bacillus subtilis >gi|483941|gb|AAC36944.1| (L32599)
blt gene product [Bacillus subtilis]
>gi|1303699|dbj|BAA12355.1| (D84432) Blt [Bacillus
subtilis] >gi|2635104|emb|CAB14600.1| (Z99117)
multidrug-efflux transporter [Bacillus subtilis]
Length = 400
Score = 96.0 bits (235), Expect = 7e-19
Identities = 106/406 (26%), Positives = 195/406 (47%), Gaps = 48/406 (11%)
Query: 20 RKITMRKNILMFAIGMFFADFAW-GLGFPYLGVYMKLI---GGTM-FLVGLLSVVYNLTS 74
+ I +K I + + F F GL P + +MK++ G TM +LV ++ +TS
Sbjct: 3 KSINEQKTIFIILLSNIFVAFLGIGLIIPVMPSFMKIMHLSGSTMGYLVAAFAISQLITS 62
Query: 75 TIFQYPF-GYLSDKTGKRKPFIILGILASGTTYGLVALITSPILLLGLRAFQGALGASLA 133
PF G D+ G++K IILG+L + + L T + R G A +
Sbjct: 63 -----PFAGRWVDRFGRKK-MIILGLLIFSLSELIFGLGTHVSIFYFSRILGGVSAAFIM 116
Query: 134 PAHSALISELSP--RIGSMFGFFGFVENLGFMAGNFAGGYIVKTLGMKMMFIITSLVSLI 191
PA +A +++++ G+ + GF+ G AGG+I G++M F S ++LI
Sbjct: 117 PAVTAYVADITTLKERSKAMGYVSAAISTGFIIGPGAGGFIAG-FGIRMPFFFASAIALI 175
Query: 192 GIL---FLLKIKERGRAKAGGDRLIIVKEGRESDRVELKEIAFKKLMKGRLG-IFYVAVL 247
+ F+LK + L I E R KE F K +K + ++++A +
Sbjct: 176 AAVTSVFILK-----------ESLSI--EERHQLSSHTKESNFIKDLKRSIHPVYFIAFI 222
Query: 248 LAMIASGAV--YATV-SVYFEEKFG--EEFVGYLFGIDSLSAA-LSALIIGRLIDKYGEK 301
+ + + + Y TV S++ + KFG + + + I S+ A + L+ G+L++K GEK
Sbjct: 223 IVFVMAFGLSAYETVFSLFSDHKFGFTPKDIAAIITISSIVAVVIQVLLFGKLVNKLGEK 282
Query: 302 LFFRLSLV-GYIITFMGYALANSVIIMALISILSGLKWTMLTNSSSTYVARRVPTSERGQ 360
+L L+ G I+ F+ ++ + ++ L++ L + +L + + +++ + +++G
Sbjct: 283 RMIQLCLITGAILAFVSTVMSGFLTVL-LVTCFIFLAFDLLRPALTAHLSN-MAGNQQGF 340
Query: 361 GMGLLNTMMTLGWVIGPLIGGILADNFGFAVMLYSTVPILFLGFLL 406
G+ +T +LG + GP +GGIL D L P LF GF++
Sbjct: 341 VAGMNSTYTSLGNIFGPALGGILFD-------LNIHYPFLFAGFVM 379
>dbj|BAB06030.1| (AP001515) unknown conserved protein [Bacillus halodurans]
Length = 391
Score = 95.6 bits (234), Expect = 1e-18
Identities = 91/394 (23%), Positives = 164/394 (41%), Gaps = 33/394 (8%)
Query: 26 KNILMFAIGMFFADFAWGLGFPYLGVYMKLIGGTMFLVGLLSVVYNLTSTIFQYPFGYLS 85
+N ++F FF F+ + P L Y++ +GG +GL+ Y + + P G +S
Sbjct: 8 RNKVIFYSVSFFLWFSHFVYLPILSPYIEFLGGKYVYIGLVLSSYGFMQFVCRLPIGIVS 67
Query: 86 DKTGKRKPFIILGILASGTTYGLVALITSPILLLGLRAFQGALGASLAPAHSALISE--L 143
D +RKPFII G+ S + L AL L+L RA G A+ + L S
Sbjct: 68 DLLKRRKPFIIFGMGTSAASCFLFALTEHLGLVLLARALAGVAAATWV-VFTVLFSSCFT 126
Query: 144 SPRIGSMFGFFGFVENLGFMAGNFAGGYIVKTLGMKMMFIITSLVSLIGILFLLKIKERG 203
R+ F+ L + G G++V +LG F I L+SL+G L I E
Sbjct: 127 DSRVHEAMSSISFIVVLAQLLGMIVSGFLVDSLGWHAPFWIGGLLSLLGATLALLIYEPN 186
Query: 204 RAKAGGDRLIIVKEGRESDRVELKEIAFKKLMKGRLGIFYVAVLLAMIASGAVYATVSVY 263
VK G +L + + L+ L + +++++ I ++ + Y
Sbjct: 187 -----------VKAGAPVQLGDLSSVIREPLL---LKVSFLSIIAHSIIFTTMFGFLPTY 232
Query: 264 FE----EKFGEEFVGYLFGIDSLSAALSALIIGR-LIDKYGEKLFFRLSLVGYIITFMGY 318
G F+ + F I A+ L +G ++ + G+ ++ +G ++ +
Sbjct: 233 ATRIGLNTQGLSFIVFAFMIPH---AIGTLFLGNVIVPRLGKWNALNVAFLGTVVFTLLT 289
Query: 319 ALANS----VIIMALISILSGLKWTMLTNSSSTYVARRVPTSERGQGMGLLNTMMTLGWV 374
+ ++ +++ G+ + +L S +AR +R MG+ + +G
Sbjct: 290 PMIDTKVPLMVVQGFNGFFLGILFPLLLGMSIESIAR----EKRATAMGVYQALYAVGMF 345
Query: 375 IGPLIGGILADNFGFAVMLYSTVPILFLGFLLSF 408
GP + GIL+ + G AV Y + L +L F
Sbjct: 346 TGPFLAGILSASLGLAVGFYFCAGLALLASILVF 379
>pir||D75094 transport protein, permease PAB0761 - Pyrococcus abyssi (strain
Orsay) >gi|5458569|emb|CAB50057.1| (AJ248286) TRANSPORT
PROTEIN, permease [Pyrococcus abyssi]
Length = 372
Score = 94.4 bits (231), Expect = 2e-18
Identities = 99/383 (25%), Positives = 171/383 (43%), Gaps = 42/383 (10%)
Query: 28 ILMFAIGMFFADFAWGLGFPYLG-VYMKLIGGTMFLVGLLSVVYNLTSTIFQYPFGYLSD 86
+++ ++G F +++ + P L + MK +G +GLL L ++ Q P GY+ D
Sbjct: 7 LILISLGWIF-NYSHRMAVPSLAPIIMKDLGINNAEIGLLMTSLLLPYSLIQVPAGYIGD 65
Query: 87 KTGKRKPFIILGILASGTTYGLVALITSPILLLGLRAFQGAL-GASLAPAHSALISEL-S 144
K G++K + + IL + L+ L L+ +RA G G APA +ALISEL
Sbjct: 66 KIGRKK-LLTISILGYSLSSALIVLTRDYWDLVTVRALYGFFAGLYYAPA-TALISELFR 123
Query: 145 PRIGSMFGFFGFVENLGFMAGNFAGGYIVKTLGMKMMFIITSLVS-LIGILFLLKIKERG 203
R GS GFF +G + TL + F++ S++S ++GIL ++ IK
Sbjct: 124 ERKGSALGFFMVGPAIGSGITPLIVVPVALTLSWRYAFLVLSIMSSIVGILLMVAIK--- 180
Query: 204 RAKAGGDRLIIVKEGRESDRVELKEIAFKKLMKGRLGIFYVAVLLAMIASGAVYAT---- 259
+ ++++ + FK G+F ++ L + GA +A
Sbjct: 181 -----------------GEPIKVEGVKFKIPR----GVFLLS-LANFLGLGAFFAMLTFL 218
Query: 260 VSVYFEEKFGEEFVGYLFGIDSLSAALSALIIGRLIDKYGEKLFFRLSLVGYIITFMGYA 319
VS G E +F + SL L ++I G L D G+ + ++TF+
Sbjct: 219 VSYLVSRGVGMEKASLMFSMLSLVGILGSIIAGFLYDHLGKVSVLLAYALNSLLTFLVIV 278
Query: 320 LANSVIIMALISILSGLKWTMLTNSSSTYVARRVPTSERGQGMGLLNTMMTLGWVIGPLI 379
+ + + ++ L +L + M + Y + + G MG +N + G IGP I
Sbjct: 279 IPSPLFLIPLGLVLYSVGGIM-----TAYTSEKASRENLGVVMGFVNMVGFFGATIGPYI 333
Query: 380 GGILADNFGFAVMLYSTVPILFL 402
G L D G+++ L S VP+ +L
Sbjct: 334 VGFLIDRLGYSLALLS-VPLAYL 355
>pir||S74875 quinolone resistance protein norA - Synechocystis sp. (strain PCC
6803) >gi|1652918|dbj|BAA17836.1| (D90909) quinolene
resistance protein NorA [Synechocystis sp.]
Length = 418
Score = 93.6 bits (229), Expect = 4e-18
Identities = 84/370 (22%), Positives = 167/370 (44%), Gaps = 13/370 (3%)
Query: 23 TMRKNILMFAIGMFFADFAWGLGFPYLGVYMKLIGGTMFLVGLLSVVYNLTSTIFQYPFG 82
T + L+FA + F L P L +Y + +G T VG + + L + G
Sbjct: 14 TQKTFALLFASVLMFWLSLTAL-LPTLPMYAQDVGATKQQVGWIMGSFALGLLGSRIWIG 72
Query: 83 YLSDKTGKRKPFIILGILASGTTYGLVALITSPI-LLLGLRAFQGALGASLAPAHSALIS 141
L D+ G++ +I ++ + G L+T+ + L+ +RAF G A+ +++L+
Sbjct: 73 QLVDRRGRKIAIVIGALVVALAPLGY--LLTATVGALMAIRAFHGICLAAYTTGYNSLVV 130
Query: 142 ELSP--RIGSMFGFFGFVENLGFMAGNFAGGYIVKTLGMKMMFIITSLVSLIGILFLLKI 199
+LSP + G + G+ +G G G YI +++G + +FI +SL+ I ++ L++
Sbjct: 131 DLSPPQQRGEIIGYMSLAVPIGMGFGPAVGAYISQSIGYEFLFIASSLLGFISLVLALQV 190
Query: 200 KERGRAKAGGDRLIIVKEGRESDRVELKEIAFKKLMKGRLGIFYVAVLLAMIASGAVYAT 259
+E + DR + I K L + + + +LL + G +
Sbjct: 191 RENRPPDQSSAEDVF------GDRPRPRSIG-KLLTSRSMAVPTLVLLLIGLLFGNLATF 243
Query: 260 VSVYFEEKFGEEFVGYLFGIDSLSAALSALIIGRLIDKYGEKLFFRLSLVGYIITFMGYA 319
+ ++ E + G + + ++++ + L +G L D YG LF SL+ Y+++ + A
Sbjct: 244 LPLFVREIDLATYAGVFYSVAAIASFVPRLFLGSLADTYGRGLFIVGSLICYLLSMVCLA 303
Query: 320 LANSVIIMALISILSGLKWTMLTNSSSTYVARRVPTSERGQGMGLLNTMMTLGWVIGPLI 379
A++ + + L G +L ++ ++ R ERG+ + + G I I
Sbjct: 304 QADNSWELLTAAALEGAGSGILLPTTIALISDRSSLEERGRVFSVCMSGFDGGIAIAAPI 363
Query: 380 GGILADNFGF 389
G+L + FG+
Sbjct: 364 MGVLNEIFGY 373
>gi|11498923 multidrug resistance protein [Archaeoglobus fulgidus]
>gi|7483887|pir||D69415 multidrug resistance protein
homolog - Archaeoglobus fulgidus
>gi|2649251|gb|AAB89920.1| (AE001012) multidrug
resistance protein [Archaeoglobus fulgidus]
Length = 371
Score = 93.6 bits (229), Expect = 4e-18
Identities = 90/374 (24%), Positives = 163/374 (43%), Gaps = 38/374 (10%)
Query: 28 ILMFAIGMFFADFAWGLGFPYLGVYMKLIGGTMFLVGLLSVVYNLTSTIFQYPFGYLSDK 87
+L + FFA + P + Y +G ++FL + V+ L I PFG LS+
Sbjct: 1 MLRLILSGFFAYASLSCVIPIIPSYASSLGASVFLSAFAAGVFALFPAIAMTPFGMLSEV 60
Query: 88 TGKRKPFIILGILASGTTYGLVALITSPILLLGLRAFQGALGASLAPAHSALISELSP-- 145
G+R+ F++ G + S L ++ LL+ R G A P+ +AL++++S
Sbjct: 61 YGRRR-FLVAGAVTSLLASLLYLQSSTAELLVFSRTLHGLGSALYIPSINALVADISEES 119
Query: 146 RIGSMFGFFGFVENLGFMAGNFAGGYIVKTLGMKMMFIITSLVSLIGILFLLKIKERGRA 205
R G G LGF AG AGG++ G+K +F++ + S ++ ++ ++ER +
Sbjct: 120 RRGEAMGKLQTALMLGFFAGPLAGGFVSDFFGVKAVFLLALVFSAAALVPVVGVRERSKG 179
Query: 206 KAGGDRLIIVKEGRESDRVELKEIAFKKLMKGRLGIFYVAVLLAMIASGAVYATVSVYFE 265
G K+ F + + + +V +A +S A++A E
Sbjct: 180 GEIG-----------------KQFIFPRKLAPLFAVMFVG--MATGSSLALFAIPFYAPE 220
Query: 266 EKFGEEFVGYLFGIDSLSAALSALIIGRLIDKYGEKLFFRLSLVGYIITFMGY--ALANS 323
++ G L + L +A+ + G L D+ G + +L+G ++T +G A
Sbjct: 221 LNISQQQAGLLVAVLFLFSAIIRVPAGILADRAGRNV---TALLGMVVTGLGLFSAFKPD 277
Query: 324 VIIMALISIL----SGLKWTMLTNSSSTYVARRVPTSERGQGMGLLNTMMTLGWVIGPLI 379
+ L S+L +G+ T + ++S Y RG MG+ NT++ G G +
Sbjct: 278 FPFLFLASLLCGAGNGIVNTAVFAAASDY-------ENRGYAMGVANTVLNAGIFAGTTL 330
Query: 380 GGILADNFGFAVML 393
G +A F M+
Sbjct: 331 AGFMAGFLSFQSMM 344
>sp|P25744|YCEE_ECOLI HYPOTHETICAL 43.9 KDA PROTEIN IN MSYB-HTRB INTERGENIC REGION (ORF1)
>gi|95972|pir||B42290 probable membrane protein b1053 -
Escherichia coli >gi|42029|emb|CAA42562.1| (X59939) ORF1
[Escherichia coli] >gi|1787291|gb|AAC74137.1| (AE000206)
putative transport protein [Escherichia coli K12]
>gi|4062627|dbj|BAA35851.1| (D90742) Probable integral
membrane protein. [Escherichia coli]
>gi|4062636|dbj|BAA35862.1| (D90743) Probable integral
membrane protein. [Escherichia coli]
Length = 408
Score = 91.7 bits (224), Expect = 1e-17
Identities = 93/394 (23%), Positives = 178/394 (44%), Gaps = 28/394 (7%)
Query: 22 ITMRKNILMFAIGMFFADFAWGLGFPYLGVYMKLIG--GTMFLVGLLSVVYNLT---STI 76
I ++N+++ +G F A+ L P+L +Y++ +G G L +V+++T S I
Sbjct: 10 INWKRNLIVAWLGCFLTGAAFSLVMPFLPLYVEQLGVTGHSALNMWSGIVFSITFLFSAI 69
Query: 77 FQYPFGYLSDKTGKRKPFIILGILASGTTYGLVALITSPILLLGLRAFQGALGASLAPAH 136
+G L+D+ G RK ++ L G L+ L + L LRA G LG P
Sbjct: 70 ASPFWGGLADRKG-RKLMLLRSALGMGIVMVLMGLAQNIWQFLILRALLGLLGG-FVPNA 127
Query: 137 SALISELSPR--IGSMFGFFGFVENLGFMAGNFAGGYIVKTLGMKMMFIIT-SLVSLIGI 193
+ALI+ PR G G G + G AGG + + G++ +F IT S++ L
Sbjct: 128 NALIATQVPRNKSGWALGTLSTGGVSGALLGPMAGGLLADSYGLRPVFFITASVLILCFF 187
Query: 194 LFLLKIKERGRAKAGGDRLIIVKEGRESDRVELKEIAFKKLMKGRLGIFYVAVLLAMIAS 253
+ L I+E+ + + + + + ++E+ + +V L+ +A+
Sbjct: 188 VTLFCIREKFQPVS------------KKEMLHMREVVTSLKNPKLVLSLFVTTLIIQVAT 235
Query: 254 GAVYATVSVYFEEKFGE----EFV-GYLFGIDSLSAALSALIIGRLIDKYGEKLFFRLSL 308
G++ +++Y E G F+ G + + ++A LSA +G+L D+ G + +L
Sbjct: 236 GSIAPILTLYVRELAGNVSNVAFISGMIASVPGVAALLSAPRLGKLGDRIGPEKILITAL 295
Query: 309 VGYIITFMGYALANSVIIMALISILSGLKWTMLTNSSSTYVARRVPTSERGQGMGLLNTM 368
+ ++ + + + + + ++ L G L + T + G+ +
Sbjct: 296 IFSVLLLIPMSYVQTPLQLGILRFLLGAADGALLPAVQTLLVYNSSNQIAGRIFSYNQSF 355
Query: 369 MTLGWVIGPLIGGILADNFGF-AVMLYSTVPILF 401
+G V GPL+G ++ N+GF AV L + +LF
Sbjct: 356 RDIGNVTGPLMGAAISANYGFRAVFLVTAGVVLF 389
>dbj|BAB05494.1| (AP001513) multidrug-efflux transporter [Bacillus halodurans]
Length = 409
Score = 91.3 bits (223), Expect = 2e-17
Identities = 85/381 (22%), Positives = 176/381 (45%), Gaps = 36/381 (9%)
Query: 21 KITMRKNILMFAIGMFFADFAWGLGFPYLGVYMKLIGGTMFLVGLLSVVYNLTSTIFQYP 80
K R +++ I MF A ++G+ P L Y++ IG GL+ ++ +
Sbjct: 2 KSEQRHKMILLMINMFIAIASFGIIIPILPAYLESIGEGGTAAGLMIAIFAGAQLVMSPV 61
Query: 81 FGYLSDKTGKRKPFIILGILASGTTYGLVALITSPILLLGLRAFQGALGASLAPAHSALI 140
G +D+ G+R IILG+ + + S L R G A L PA A +
Sbjct: 62 AGKWTDQYGRRY-MIILGLGGLTLSMFVFYFFDSIWWLYASRVVGGVGAALLIPAIFAYV 120
Query: 141 SELSPRIGSMFG--FFGFVENLGFMAGNFAGGYIVKTLGMKMMFIITSLVSLIGILFLLK 198
++++ G +LGF+ G GG++ G+KM ++++++SL+ +LF +
Sbjct: 121 ADITTIDERAKGNSLVSAAMSLGFVVGPGIGGFLAD-FGLKMPILLSAILSLVAVLFSIM 179
Query: 199 IKERGRAKAGGDRLIIVKEGRESDRVELKEIAFKKLMKGRLGIFYVAVLLAMIASGAVYA 258
+ + + + + + ++ ES V K+L++ +++ +++ ++ S + A
Sbjct: 180 LLKESQTEEAKE--LTAEQVSESPLV-------KQLIQSVKKPYFIPLVITLVMSFGLMA 230
Query: 259 TVSV---YFEEKFGE---EFVGYLFGIDSLSAALSALIIGRLIDKYGEK----LFFRLSL 308
S+ + + +FG + L I ++S + ++ RL+ GE+ LF ++
Sbjct: 231 YESILGLFVDNQFGATPGQIAILLTSIGTISVIVQLFVVERLVRWLGERTVLSLFLGVAS 290
Query: 309 VGYIITFM----GYALANSVIIMALISILSGLKWTMLTNSSSTYVARRVPTSERGQGMGL 364
G++++ G A ++ I SIL + T+++ ++ +E+G MG+
Sbjct: 291 FGFLLSLFAPSYGMFFAVTMFIFLATSILRPVLTTLIS---------KLAGNEQGFAMGM 341
Query: 365 LNTMMTLGWVIGPLIGGILAD 385
N M++G V+GP + G+L D
Sbjct: 342 NNAYMSIGNVLGPALAGVLFD 362
>dbj|BAB04893.1| (AP001511) multidrug-efflux transporter [Bacillus halodurans]
Length = 399
Score = 90.5 bits (221), Expect = 3e-17
Identities = 91/369 (24%), Positives = 171/369 (45%), Gaps = 27/369 (7%)
Query: 25 RKNILMFAIGMFFADFAWGLGFPYLGVYMKLIGGTMFLVGLLSVVYNLTSTIFQYPFGYL 84
RK +LM + MF GL P L Y++ G + +GLL +++ + +G L
Sbjct: 6 RKPLLMLMVNMFVVMMGIGLVIPILPYYIEAFGASSVELGLLIAIFSFMQFLLAPFWGRL 65
Query: 85 SDKTGKRKPFIILGILASGTTYGLVALITSPILLLGLRAFQGALGASLAPAHSALISELS 144
SDK G RKP I +G+ + A T +L R GA G+++ PA A +S+ +
Sbjct: 66 SDKVG-RKPLIAVGMFGFAVAEFIFAFATQFWMLFVSRILAGAFGSAVMPAAMAYVSDRT 124
Query: 145 --PRIGSMFGFFGFVENLGFMAGNFAGGYIVK-TLGMKMMF--IITSLVSLIGILFLLKI 199
+ G G G LG + G GG++ + +L +F S ++ +L+L
Sbjct: 125 SEEKRGHGMGLLGASMALGIVVGPGIGGWLAEFSLATPFLFAGFAASFAAIFSLLWL--- 181
Query: 200 KERGRAKAGGDRLIIVKEGRESDRVELKEIAFKKLMKGRLG--IFYVAVLLAMIASGAVY 257
+ L + K E + V + + + ++ +G +F V L +A+
Sbjct: 182 ---------PESLPLEKRKTEVEPVN-QFVQMWQAVRSPIGFLLFLVFGLSFGLANFQTI 231
Query: 258 ATVSVYFEEKFGEEFVGYLFGIDSLSAALS-ALIIGRLIDKYGEK--LFFRLSLVGYIIT 314
+ + VG++ + + A++ ++GRL ++YGE+ + LSL G I
Sbjct: 232 FGIFALHRFHYNPSEVGFIMVLTGIVGAIAQGSLVGRLTERYGEEKVVLGSLSLSG--IG 289
Query: 315 FMGYALANSVIIMALISILSGLKWTMLTNSSSTYVARRVPTSERGQGMGLLNTMMTLGWV 374
F+ LA + + + L L ++L + ++++ ++ ++G MGL N++++LG V
Sbjct: 290 FLIMMLAFNYWTVIATTCLFFLGNSILRPAVQSFLS-KMAGDQQGMIMGLNNSILSLGNV 348
Query: 375 IGPLIGGIL 383
+G L+ G+L
Sbjct: 349 VGALLAGLL 357
Score = 78.4 bits (190), Expect = 1e-13
Identities = 58/167 (34%), Positives = 80/167 (47%), Gaps = 10/167 (5%)
Query: 244 VAVLLAMIASGAVYATVSVYFEEKFGEEFV--GYLFGIDSLSAALSALIIGRLIDKYGEK 301
V + + M+ G V + Y+ E FG V G L I S L A GRL DK G K
Sbjct: 14 VNMFVVMMGIGLVIPILP-YYIEAFGASSVELGLLIAIFSFMQFLLAPFWGRLSDKVGRK 72
Query: 302 LFFRLSLVGYIITFMGYALANSVIIMALISILSGLKWTMLTNSSSTYVARRVPTSERGQG 361
+ + G+ + +A A ++ + IL+G + + ++ YV+ R +RG G
Sbjct: 73 PLIAVGMFGFAVAEFIFAFATQFWMLFVSRILAGAFGSAVMPAAMAYVSDRTSEEKRGHG 132
Query: 362 MGLLNTMMTLGWVIGPLIGGILADNFGFAVMLYSTVPILFLGFLLSF 408
MGLL M LG V+GP IGG LA+ F A P LF GF SF
Sbjct: 133 MGLLGASMALGIVVGPGIGGWLAE-FSLA------TPFLFAGFAASF 172
>dbj|BAB06311.1| (AP001516) unknown conserved protein [Bacillus halodurans]
Length = 409
Score = 90.1 bits (220), Expect = 4e-17
Identities = 89/400 (22%), Positives = 164/400 (40%), Gaps = 29/400 (7%)
Query: 25 RKNILMFAIGMFFADFAWGLGFPYLGVYMKLIGGT-----MFLVGLLSVVYNLTSTIFQY 79
++N+ + + F A + P+L +Y++ +G T G++ LT+ +F
Sbjct: 5 KRNLYILVVCQFLVVSAMTMIIPFLPLYLQELGVTDPSEVSLWAGIIFAANFLTAFLFSP 64
Query: 80 PFGYLSDKTGKRKPFIILGILASGTTYGLVALITSPILLLGLRAFQGALGASLAPAHSAL 139
+ L+D+ G RK I+ GL P+ LL LR G + + PA L
Sbjct: 65 LWSRLADRYG-RKMMILRSGFGMALIIGLTGFAQGPLSLLCLRLLNGVISGFI-PASIGL 122
Query: 140 ISELSPR--IGSMFGFFGFVENLGFMAGNFAGGYIVKTLGMKMMFIITSL-VSLIGILFL 196
++ +P+ G GF G + G GG + + G +M+F +T L + + ++ L
Sbjct: 123 VATNTPKEKAGYALGFLQAGAVSGGICGPLIGGIMAQAFGYRMIFFLTGLCIFIAALVVL 182
Query: 197 LKIKERGRAKAGGDRLIIVKEGRESDRVELKEI-AFKKLMKGRLGIFYVAVLLAMIASGA 255
L + E+ KE + + E K+I A + + YV V L A
Sbjct: 183 LFVNEQFTPNP--------KEEKTNTWGEFKKITAIRPIFS-----LYVVVFLIQFAVMG 229
Query: 256 VYATVSVYFEEKFGEE----FVGYLFGIDSLSAALSALIIGRLIDKYGEKLFFRLSLVGY 311
V +S++ EE F G + LS++ +G+L DK G L+G
Sbjct: 230 VNPLISLFVEELVSGVNVALFAGLAISATGFANMLSSMQLGKLSDKAGAHHVLFFCLLGT 289
Query: 312 IITFMGYALANSVIIMALISILSGLKWTMLTNSSSTYVARRVPTSERGQGMGLLNTMMTL 371
+I + A + + ++ GL L +++ V P + G + + L
Sbjct: 290 VIFMIPQAFVQQLWQLIVLRFFVGLSLGGLLPAANALVRMHAPKGMESRTYGFSTSALYL 349
Query: 372 GWVIGPLIGGILADNFGF-AVMLYSTVPILFLGFLLSFRI 410
G ++GP +GG + G + L S +L +++ ++
Sbjct: 350 GNMVGPTVGGAVVATVGIRGLFLISAFTLLLTVWIVKGKV 389
>pir||E75042 transporter (major facilitator family) related PAB0874 - Pyrococcus
abyssi (strain Orsay) >gi|5458747|emb|CAB50234.1|
(AJ248287) TRANSPORTER (MAJOR FACILITATOR FAMILY)
related [Pyrococcus abyssi]
Length = 392
Score = 89.7 bits (219), Expect = 5e-17
Identities = 105/391 (26%), Positives = 170/391 (42%), Gaps = 46/391 (11%)
Query: 27 NILMFAIGMFFADFAWGLGFPYLGVYM-------KLIGGTMFLVGLLSVVYNLTSTIFQY 79
N+ + + F D + + P + Y+ KL G+ ++GL+ + S++F+
Sbjct: 12 NVFLLGLVSFLNDMSSEMIAPIVPSYLTDILKIGKLASGS--IMGLIESL----SSLFKV 65
Query: 80 PFGYLSDKTGKRKPFIILGILASGTTYGLVALITSPILLLGLRAFQG-ALGASLAPAHSA 138
FGY+SDK KRK F+ LG L S + G +A+ S L LR G AP A
Sbjct: 66 LFGYISDKFRKRKAFVALGYLISTISKGALAVTHSWWDFLILRILDRIGKGIRTAP-RDA 124
Query: 139 LISELSP--RIGSMFGFFGFVENLGFMAGNFAGGYIV-------KTLGMKMMFIITSLVS 189
LI+E S + G FGF ++ LG +AG ++ K L + +F+I+++
Sbjct: 125 LIAESSEKGKSGKSFGFHRMMDTLGAVAGPLVAMGLLALLANYPKELAYRYIFLISAVPG 184
Query: 190 LIGILF-LLKIKERGRAKAGGDRLIIVKEGRESDRVELKEIAFKKLMKGRLGIFYVAVLL 248
+IG+L LL +K++G V+ K L L IF V V +
Sbjct: 185 VIGVLIVLLLVKDKG------------------SEVKKKIKGISALKSSNLRIFLVIVAI 226
Query: 249 AMIASGAVYATVSVYFEEKFGEEFVGY-LFGIDSLSAALSALIIGRLIDKYGEKLFFRLS 307
A + + YA EE F G + + ++ ALSA IG DK G+K+ +
Sbjct: 227 AALGRYS-YAFTLWKAEELGYSVFQGLGFYALFNVIYALSAYPIGYYSDKVGKKIIITIG 285
Query: 308 LVGYIITFMGYALANSVIIMALISILSGLKWTMLTNSSSTYVARRVPTSERGQGMGLLNT 367
+ + +A AN++ + L +L GL + Y+A E+G +G +T
Sbjct: 286 FGIAGLASLIFAYANNLPTLLLAFVLYGLYMAIEDTIPRAYMADLAKEFEKGTVIGAYHT 345
Query: 368 MMTLGWVIGPLIGGILADNFGFAV-MLYSTV 397
+ + +I G L + V LYS V
Sbjct: 346 VFGVFVFPASIIVGYLWQTYSLTVGFLYSAV 376
>gb|AAA16158.1| (M80252) norA1199 protein [Staphylococcus aureus]
>gi|153055|gb|AAA26658.1| (M97169) norA [Staphylococcus
aureus]
Length = 388
Score = 89.3 bits (218), Expect = 7e-17
Identities = 89/376 (23%), Positives = 162/376 (42%), Gaps = 38/376 (10%)
Query: 24 MRKNILMFAIGMFFADFAWGLGFPYLGVYMKLIGGTMFLVGLLSVVYNLTSTIFQYPFGY 83
M K IL+ +F GL P L VY+K +G T +GLL + L+ I G
Sbjct: 1 MNKQILVLYFNIFLIFLGIGLVIPVLPVYLKDLGLTGSDLGLLVAAFALSQMIISPFGGT 60
Query: 84 LSDKTGKRKPFIILGILASGTTYGLVALITSPILLLGLRAFQGALGASLAPAHSALISEL 143
L+DK GK K I +G++ + + A+ + ++L+ R G + P + LI+++
Sbjct: 61 LADKLGK-KLIICIGLILFSVSEFMFAIGQNFLILMLSRVIGGMSAGMVMPGVTGLIADI 119
Query: 144 SP--RIGSMFGFFGFVENLGFMAGNFAGGYIVKTLGMKMMFIITSLVSLIGILFLLKIKE 201
SP + FG+ + N GF+ G GG++ + + +M F + ++ +
Sbjct: 120 SPSHQKAKNFGYMSAIINSGFILGPGIGGFMAE-VSHRMPFYFAGALGILAFIM------ 172
Query: 202 RGRAKAGGDRLIIVKEGRESDRVELKEIAFKKLMKGRLGIFYVAVLLAMIASGAVYATVS 261
++++ + ++ +++ + L K +F V+L ++ S + A +
Sbjct: 173 ---------SIVLIHDPKKVSTNGFQKLEPQLLTKINWKVFITPVILTLVLSFGLSAFET 223
Query: 262 VYFEEKFGEEFVGYLFGIDSLSAALSALIIGRLIDKYGEKLFFRLSLVGYIITFMGYALA 321
+Y + + V Y D A I G L Y F + +TF+ ++L
Sbjct: 224 LY--SLYTADKVNY-SPKDISIAITGGGIFGALFQIY---FFDKFMKYFSELTFIAWSLI 277
Query: 322 NSVIIMALISILSGLKWTMLTNSSSTYVA------------RRVPTSERGQGMGLLNTMM 369
SVI++ L+ I G WT++ S ++ + +G GL +T
Sbjct: 278 YSVIVLVLLVIADGY-WTIMVISFVVFIGFDMIRPAITNYFSNIAGDRQGFAGGLNSTFT 336
Query: 370 TLGWVIGPLIGGILAD 385
++G IGPLI G L D
Sbjct: 337 SMGNFIGPLIAGALFD 352
>pir||H71070 hypothetical protein PH1260 - Pyrococcus horikoshii
>gi|3257679|dbj|BAA30362.1| (AP000005) 372aa long
hypothetical protein [Pyrococcus horikoshii]
Length = 372
Score = 88.9 bits (217), Expect = 9e-17
Identities = 98/380 (25%), Positives = 168/380 (43%), Gaps = 36/380 (9%)
Query: 28 ILMFAIGMFFADFAWGLGFPYLG-VYMKLIGGTMFLVGLLSVVYNLTSTIFQYPFGYLSD 86
+++ ++G F +++ + P L + MK + VGLL L ++ Q P GY+ D
Sbjct: 7 LILISLGWIF-NYSHRMAVPSLAPILMKELSINNTEVGLLMTALLLPYSLIQVPAGYIGD 65
Query: 87 KTGKRKPFIILGILASGTTYGLVALITSPILLLGLRAFQGAL-GASLAPAHSALISEL-S 144
K G++K + L IL + L+ L + L+ +RA G G APA S LISEL
Sbjct: 66 KIGRKK-LLTLSILGYSISSALIVLARNYWDLVAIRALYGFFAGLYYAPATS-LISELFR 123
Query: 145 PRIGSMFGFFGFVENLGFMAGNFAGGYIVKTLGMKMMFIITSLVS-LIGILFLLKIKERG 203
+ GS GFF +G + L ++ F++ S++S ++G+L +L +K
Sbjct: 124 EKKGSALGFFMIGPAIGSGITPLIVVPVALMLNWRLSFLVLSIMSSIVGVLLVLTVK--- 180
Query: 204 RAKAGGDRLIIVKEGRESDRVELKEIAFKKLMKGRLGIFYVAVLLAMIASGAVYATVSVY 263
+ VE++ F + KG L + +A L + A A+ + Y
Sbjct: 181 -----------------GEPVEVERAKFS-IPKGVL-LLSLANFLGLGAFFAMLTFLVSY 221
Query: 264 FEEKFGE-EFVGYLFGIDSLSAALSALIIGRLIDKYGEKLFFRLSLVGYIITFMGYALAN 322
K + + +F I SL ++ G L D G+ F L+ +++TF+
Sbjct: 222 LVSKGVDIKEASLMFSILSLVGVFGSVTAGFLYDYAGKVSVFLAYLLNFLLTFLIIVFPT 281
Query: 323 SVIIMALISILSGLKWTMLTNSSSTYVARRVPTSERGQGMGLLNTMMTLGWVIGPLIGGI 382
++++ L GL + + Y A + S G MG +N + G GP + G
Sbjct: 282 PLLLIPL-----GLVLYSVGGIITAYTAEKAEKSNLGVVMGFVNMVGFFGATTGPYVVGF 336
Query: 383 LADNFGFAVMLYSTVPILFL 402
L D G++ L S VP+ +L
Sbjct: 337 LIDKLGYSRALLS-VPLAYL 355
>gi|4505527 organic cation transporter-like 2; Beckwith-Wiedemann region 1A;
Beckwith-Wiedemann syndrome chromosome region 1,
candidate a; imprinted polyspecific membrane transporter
1 [Homo sapiens] >gi|2921449|gb|AAC04787.1| (AF037064)
organic cation transporter-like protein 2 [Homo sapiens]
Length = 424
Score = 88.2 bits (215), Expect = 2e-16
Identities = 99/376 (26%), Positives = 167/376 (44%), Gaps = 23/376 (6%)
Query: 47 PYLGVYMKLIGGTMFLVGLLSVVYNLTSTIFQYPFGYLSDKTGKRKPFIILGILASGTTY 106
PYL + +G G L + + + FG +D+ G R + L LA+ Y
Sbjct: 48 PYLS---RKLGLDSIAFGYLQTTFGVLQLLGGPVFGRFADQRGARAA-LTLSFLAALALY 103
Query: 107 GLVALITSPIL----LLGLRAFQGALGASLAPAHSALISELSP--RIGSMFGFFGFVENL 160
L+A +SP L LL GAL +L PA +I++LS + G G +
Sbjct: 104 LLLAAASSPALPGVYLLFASRLPGALMHTL-PAAQMVITDLSAPEERPAALGRLGLCFGV 162
Query: 161 GFMAGNFAGGYIVKTLGMKMMFIITSLVSLIGILFLLKIKERGRAKAGGDRLIIVKEGRE 220
G + G+ GG +V G++ I+ +L +L+G + A D + G
Sbjct: 163 GVILGSLLGGTLVSAYGIQCPAILAALATLLGAVLSFTCIPASTKGAKTDAQAPLPGGPR 222
Query: 221 SDRVELKEIAFKKLMKGRLGIFYVAVLLAMIASGAVYATVSVYFEEKFGEEFV--GYL-- 276
+ +LK IA + IF V V + +G S+ + F E GYL
Sbjct: 223 ASVFDLKAIASLLRLPDVPRIFLVKVA-SNCPTGLFMVMFSIISMDFFQLEAAQAGYLMS 281
Query: 277 -FGIDSLSAALSALIIGRLIDKYGEKLFFRLSLVGYIITFMGYALANSVIIMALISILSG 335
FG+ L L+IG+L + E++ R S++ +I+ + A +SV L+ + G
Sbjct: 282 FFGL--LQMVTQGLVIGQLSSHFSEEVMLRASVLVFIVVGLAMAWMSSVFHFCLL--VPG 337
Query: 336 LKWTMLTNS--SSTYVARRVPTSERGQGMGLLNTMMTLGWVIGPLIGGILADNFGFAVML 393
L +++ T + + + + + V TS+ G +GL ++ L +GP +GG+L +FG V
Sbjct: 338 LVFSLCTLNVVTDSMLIKAVSTSDTGTMLGLCASVQPLLRTLGPTVGGLLYRSFGVPVFG 397
Query: 394 YSTVPILFLGFLLSFR 409
+ V I L L+ +R
Sbjct: 398 HVQVAINTLVLLVLWR 413
>gb|AAC14725.1| (AF059663) tumor suppressing STF cDNA 5 [Homo sapiens]
Length = 424
Score = 88.2 bits (215), Expect = 2e-16
Identities = 99/376 (26%), Positives = 167/376 (44%), Gaps = 23/376 (6%)
Query: 47 PYLGVYMKLIGGTMFLVGLLSVVYNLTSTIFQYPFGYLSDKTGKRKPFIILGILASGTTY 106
PYL + +G G L + + + FG +D+ G R + L LA+ Y
Sbjct: 48 PYLS---RKLGLDSIAFGYLQTTFGVLQLLGGPVFGRFADQRGARAA-LTLSFLAALALY 103
Query: 107 GLVALITSPIL----LLGLRAFQGALGASLAPAHSALISELSP--RIGSMFGFFGFVENL 160
L+A +SP L LL GAL +L PA +I++LS + G G +
Sbjct: 104 LLLAAASSPALPGVYLLFASRLPGALMHTL-PAAQMVITDLSAPEERPAALGRLGLCFGV 162
Query: 161 GFMAGNFAGGYIVKTLGMKMMFIITSLVSLIGILFLLKIKERGRAKAGGDRLIIVKEGRE 220
G + G+ GG +V G++ I+ +L +L+G + A D + G
Sbjct: 163 GVILGSLLGGTLVSAYGIQCPAILAALATLLGAVLSFTCIPASTKGAKTDAQAPLPGGPR 222
Query: 221 SDRVELKEIAFKKLMKGRLGIFYVAVLLAMIASGAVYATVSVYFEEKFGEEFV--GYL-- 276
+ +LK IA + IF V V + +G S+ + F E GYL
Sbjct: 223 ASVFDLKAIASLLRLPDVPRIFLVKVA-SNCPTGLFMVMFSIISMDFFQLEAAQAGYLMS 281
Query: 277 -FGIDSLSAALSALIIGRLIDKYGEKLFFRLSLVGYIITFMGYALANSVIIMALISILSG 335
FG+ L L+IG+L + E++ R S++ +I+ + A +SV L+ + G
Sbjct: 282 FFGL--LQMVTQGLVIGQLSSHFSEEVLLRASVLVFIVVGLAMAWMSSVFHFCLL--VPG 337
Query: 336 LKWTMLTNS--SSTYVARRVPTSERGQGMGLLNTMMTLGWVIGPLIGGILADNFGFAVML 393
L +++ T + + + + + V TS+ G +GL ++ L +GP +GG+L +FG V
Sbjct: 338 LVFSLCTLNVVTDSMLIKAVSTSDTGTMLGLCASVQPLLRTLGPTVGGLLYRSFGVPVFG 397
Query: 394 YSTVPILFLGFLLSFR 409
+ V I L L+ +R
Sbjct: 398 HVQVAINTLVLLVLWR 413
>dbj|BAA32779.1| (AB012083) ITM [Homo sapiens]
Length = 408
Score = 88.2 bits (215), Expect = 2e-16
Identities = 99/376 (26%), Positives = 167/376 (44%), Gaps = 23/376 (6%)
Query: 47 PYLGVYMKLIGGTMFLVGLLSVVYNLTSTIFQYPFGYLSDKTGKRKPFIILGILASGTTY 106
PYL + +G G L + + + FG +D+ G R + L LA+ Y
Sbjct: 32 PYLS---RKLGLDSIAFGYLQTTFGVLQLLGGPVFGRFADQRGARAA-LTLSFLAALALY 87
Query: 107 GLVALITSPIL----LLGLRAFQGALGASLAPAHSALISELSP--RIGSMFGFFGFVENL 160
L+A +SP L LL GAL +L PA +I++LS + G G +
Sbjct: 88 LLLAAASSPALPGVYLLFASRLPGALMHTL-PAAQMVITDLSAPEERPAALGRLGLCFGV 146
Query: 161 GFMAGNFAGGYIVKTLGMKMMFIITSLVSLIGILFLLKIKERGRAKAGGDRLIIVKEGRE 220
G + G+ GG +V G++ I+ +L +L+G + A D + G
Sbjct: 147 GVILGSLLGGTLVSAYGIQCPAILAALATLLGAVLSFTCIPASTKGAKTDAQAPLPGGPR 206
Query: 221 SDRVELKEIAFKKLMKGRLGIFYVAVLLAMIASGAVYATVSVYFEEKFGEEFV--GYL-- 276
+ +LK IA + IF V V + +G S+ + F E GYL
Sbjct: 207 ASVFDLKAIASLLRLPDVPRIFLVKVA-SNCPTGLFMVMFSIISMDFFQLEAAQAGYLMS 265
Query: 277 -FGIDSLSAALSALIIGRLIDKYGEKLFFRLSLVGYIITFMGYALANSVIIMALISILSG 335
FG+ L L+IG+L + E++ R S++ +I+ + A +SV L+ + G
Sbjct: 266 FFGL--LQMVTQGLVIGQLSSHFSEEVLLRASVLVFIVVGLAMAWMSSVFHFCLL--VPG 321
Query: 336 LKWTMLTNS--SSTYVARRVPTSERGQGMGLLNTMMTLGWVIGPLIGGILADNFGFAVML 393
L +++ T + + + + + V TS+ G +GL ++ L +GP +GG+L +FG V
Sbjct: 322 LVFSLCTLNVVTDSMLIKAVSTSDTGTMLGLCASVQPLLRTLGPTVGGLLYRSFGVPVFG 381
Query: 394 YSTVPILFLGFLLSFR 409
+ V I L L+ +R
Sbjct: 382 HVQVAINTLVLLVLWR 397
>gi|11440671 organic cation transporter-like 2 [Homo sapiens]
Length = 424
Score = 88.2 bits (215), Expect = 2e-16
Identities = 99/376 (26%), Positives = 167/376 (44%), Gaps = 23/376 (6%)
Query: 47 PYLGVYMKLIGGTMFLVGLLSVVYNLTSTIFQYPFGYLSDKTGKRKPFIILGILASGTTY 106
PYL + +G G L + + + FG +D+ G R + L LA+ Y
Sbjct: 48 PYLS---RKLGLDSIAFGYLQTTFGVLQLLGGPVFGRFADQRGARAA-LTLSFLAALALY 103
Query: 107 GLVALITSPIL----LLGLRAFQGALGASLAPAHSALISELSP--RIGSMFGFFGFVENL 160
L+A +SP L LL GAL +L PA +I++LS + G G +
Sbjct: 104 LLLAAASSPALPGVYLLFASRLPGALMHTL-PAAQMVITDLSAPEERPAALGRLGLCFGV 162
Query: 161 GFMAGNFAGGYIVKTLGMKMMFIITSLVSLIGILFLLKIKERGRAKAGGDRLIIVKEGRE 220
G + G+ GG +V G++ I+ +L +L+G + A D + G
Sbjct: 163 GVILGSLLGGTLVSAYGIQCPAILAALATLLGAVLSFTCIPASTKGAKTDAQAPLPGGPR 222
Query: 221 SDRVELKEIAFKKLMKGRLGIFYVAVLLAMIASGAVYATVSVYFEEKFGEEFV--GYL-- 276
+ +LK IA + IF V V + +G S+ + F E GYL
Sbjct: 223 ASVFDLKAIASLLRLPDVPRIFLVKVA-SNCPTGLFMVMFSIISMDFFQLEAAQAGYLMS 281
Query: 277 -FGIDSLSAALSALIIGRLIDKYGEKLFFRLSLVGYIITFMGYALANSVIIMALISILSG 335
FG+ L L+IG+L + E++ R S++ +I+ + A +SV L+ + G
Sbjct: 282 FFGL--LQMVTQGLVIGQLSSHFSEEVLLRASVLVFIVVGLAMAWMSSVFHFCLL--VPG 337
Query: 336 LKWTMLTNS--SSTYVARRVPTSERGQGMGLLNTMMTLGWVIGPLIGGILADNFGFAVML 393
L +++ T + + + + + V TS+ G +GL ++ L +GP +GG+L +FG V
Sbjct: 338 LVFSLCTLNVVTDSMLIKAVSTSDTGTMLGLCASVQPLLRTLGPTVGGLLYRSFGVPVFG 397
Query: 394 YSTVPILFLGFLLSFR 409
+ V I L L+ +R
Sbjct: 398 HVQVAINTLVLLVLWR 413
>sp|P40760|YUXJ_BACSU HYPOTHETICAL 39.1 KD PROTEIN IN KAPD-PBPD INTERGENIC REGION (ORF1)
>gi|7446746|pir||C70025 multidrug-efflux transporter
homolog yuxJ - Bacillus subtilis
>gi|1934783|emb|CAB07914.1| (Z93933) unknown [Bacillus
subtilis] >gi|2635644|emb|CAB15137.1| (Z99120) alternate
gene name: yugC~similar to multidrug-efflux transporter
[Bacillus subtilis]
Length = 356
Score = 86.6 bits (211), Expect = 5e-16
Identities = 80/334 (23%), Positives = 142/334 (41%), Gaps = 27/334 (8%)
Query: 81 FGYLSDKTGKRKPFIILGILASGTTYGL----VALITSPILLLGLRAFQGALGASLAPAH 136
+G DK G +K ++A+GT L + +TS L LR G L P
Sbjct: 20 WGRFGDKRGYKKI-----LMATGTGIALSIFFMGFVTSVYQLFFLRMAMG-LVTGFIPTS 73
Query: 137 SALISELSPR--IGSMFGFFGFVENLGFMAGNFAGGYIVKTLGMKMMFIITSLVSLIGIL 194
A+IS +P+ G G + G + G GG + G F ITS V +L
Sbjct: 74 LAMISAQTPKSSAGKTLGTLQMGQVSGSLFGPLLGGMLADRFGFTYTFFITSFVIFSSVL 133
Query: 195 FLL-KIKERGRAKAGGDRLIIVKEGRESDRVELKEIAFKKLMKGRLGIFYVAVLLAMIAS 253
+L +KE+ A+ R + KE+ L + + +L +
Sbjct: 134 LVLFGVKEKHLAEKTAKRTSYSR----------KEVLSYIFHHPALWVMMLLTMLIQTGN 183
Query: 254 GAVYATVSVYFEEKFGEEFVGYLFGIDSLSAALSALIIGRLIDKYGEKLFFRLSLVGYII 313
++ +++Y E G + + G+ + L +L++ R G++ R L+G ++
Sbjct: 184 FSIQPLLALYVNELHGPVNLAFFSGMAFSATGLGSLLLARKWGDLGDRYGHRRILIGLLL 243
Query: 314 T----FMGYALANSVIIMALISILSGLKWTMLTNSSSTYVARRVPTSERGQGMGLLNTMM 369
F+ ALA+S+ ++ + L G+ L + + + P S +G+ +G +
Sbjct: 244 AASFFFIPQALASSLSVLLVFRFLFGMAMGGLLPCITAAIRVQAPGSIQGEVLGYNVSFR 303
Query: 370 TLGWVIGPLIGGILADNFGFAVMLYSTVPILFLG 403
LG V+GPL+GGI++ +F + Y T + F G
Sbjct: 304 FLGNVLGPLLGGIISSHFTISATFYVTAFLFFAG 337
>sp|P21191|NORA_STAAU QUINOLONE RESISTANCE NORA PROTEIN >gi|97835|pir||A37838 norA
protein - Staphylococcus aureus
>gi|216975|dbj|BAA14147.1| (D90119) ORF for norA
[Staphylococcus aureus]
Length = 388
Score = 86.2 bits (210), Expect = 6e-16
Identities = 83/370 (22%), Positives = 158/370 (42%), Gaps = 26/370 (7%)
Query: 24 MRKNILMFAIGMFFADFAWGLGFPYLGVYMKLIGGTMFLVGLLSVVYNLTSTIFQYPFGY 83
M K I + +F GL P L VY+K +G T +GLL + L+ I G
Sbjct: 1 MNKQIFVLYFNIFLIFLGIGLVIPVLPVYLKDLGLTGSDLGLLVAAFALSQMIISPFGGT 60
Query: 84 LSDKTGKRKPFIILGILASGTTYGLVALITSPILLLGLRAFQGALGASLAPAHSALISEL 143
L+DK GK K I +G++ + + A+ + +L+ R G + P + LI+++
Sbjct: 61 LADKLGK-KLIICIGLILFSVSEFMFAVGHNFSVLMLSRVIGGMSAGMVMPGVTGLIADI 119
Query: 144 SP--RIGSMFGFFGFVENLGFMAGNFAGGYIVKTLGMKMMFIITSLVSLIGILFLLKIKE 201
SP + FG+ + N GF+ G GG++ + + +M F + ++ +
Sbjct: 120 SPSHQKAKNFGYMSAIINSGFILGPGIGGFMAE-VSHRMPFYFAGALGILAFIM------ 172
Query: 202 RGRAKAGGDRLIIVKEGRESDRVELKEIAFKKLMKGRLGIFYVAVLLAMIAS---GAVYA 258
++++ + ++S +++ + L K +F V+L ++ S A
Sbjct: 173 ---------SIVLIHDPKKSTTSGFQKLEPQLLTKINWKVFITPVILTLVLSFGLSAFET 223
Query: 259 TVSVYFEEKFG---EEFVGYLFGIDSLSAALSALIIGRLIDKYGEKLFFRLSLVGYIITF 315
S+Y +K ++ + G A + + + E F SL+ ++
Sbjct: 224 LYSLYTADKVNYSPKDISIAITGGGIFGALFQIYFFDKFMKYFSELTFIAWSLLYSVVVL 283
Query: 316 MGYALANSVIIMALISILSGLKWTMLTNSSSTYVARRVPTSERGQGMGLLNTMMTLGWVI 375
+ AN + LIS + + + M+ + + Y + + +G GL +T ++G I
Sbjct: 284 ILLVFANGYWSIMLISFVVFIGFDMIRPAITNYFS-NIAGERQGFAGGLNSTFTSMGNFI 342
Query: 376 GPLIGGILAD 385
GPLI G L D
Sbjct: 343 GPLIAGALFD 352
>gb|AAB31949.1| (S74031) NorA {ISP794, quinolone resistance} [Staphylococcus
aureus, NCTC 8325, Peptide Insertion, 388 aa]
Length = 388
Score = 86.2 bits (210), Expect = 6e-16
Identities = 83/370 (22%), Positives = 158/370 (42%), Gaps = 26/370 (7%)
Query: 24 MRKNILMFAIGMFFADFAWGLGFPYLGVYMKLIGGTMFLVGLLSVVYNLTSTIFQYPFGY 83
M K I + +F GL P L VY+K +G T +GLL + L+ I G
Sbjct: 1 MNKQIFVLYFNIFLIFLGIGLVIPVLPVYLKDLGLTGSDLGLLVAAFALSQMIISPFGGT 60
Query: 84 LSDKTGKRKPFIILGILASGTTYGLVALITSPILLLGLRAFQGALGASLAPAHSALISEL 143
L+DK GK K I +G++ + + A+ + +L+ R G + P + LI+++
Sbjct: 61 LADKLGK-KLIICIGLILFSVSEFMFAVGHNFSVLMLSRVIGGMSAGMVMPGVTGLIADI 119
Query: 144 SP--RIGSMFGFFGFVENLGFMAGNFAGGYIVKTLGMKMMFIITSLVSLIGILFLLKIKE 201
SP + FG+ + N GF+ G GG++ + + +M F + ++ +
Sbjct: 120 SPSHQKAKNFGYMSAIINSGFILGPGIGGFMAE-VSHRMPFYFAGALGILAFIM------ 172
Query: 202 RGRAKAGGDRLIIVKEGRESDRVELKEIAFKKLMKGRLGIFYVAVLLAMIAS---GAVYA 258
++++ + ++S +++ + L K +F V+L ++ S A
Sbjct: 173 ---------SIVLIHDPKKSTTSGFQKLEPQLLTKINWKVFITPVILTLVLSFGLSAFET 223
Query: 259 TVSVYFEEKFG---EEFVGYLFGIDSLSAALSALIIGRLIDKYGEKLFFRLSLVGYIITF 315
S+Y +K ++ + G A + + + E F SL+ ++
Sbjct: 224 LYSLYTADKVNYSPKDISIAITGGGIFGALFQIYFFDKFMKYFSELTFIAWSLLYSVVVL 283
Query: 316 MGYALANSVIIMALISILSGLKWTMLTNSSSTYVARRVPTSERGQGMGLLNTMMTLGWVI 375
+ AN + LIS + + + M+ + + Y + + +G GL +T ++G I
Sbjct: 284 ILLVFANDYWSIMLISFVVFIGFDMIRPAITNYFS-NIAGERQGFAGGLNSTFTSMGNFI 342
Query: 376 GPLIGGILAD 385
GPLI G L D
Sbjct: 343 GPLIAGALFD 352
>gb|AAB82727.1| (AF028738) imprinted multi-membrane spanning polyspecific
transporter-related protein [Homo sapiens]
Length = 408
Score = 86.2 bits (210), Expect = 6e-16
Identities = 99/376 (26%), Positives = 166/376 (43%), Gaps = 23/376 (6%)
Query: 47 PYLGVYMKLIGGTMFLVGLLSVVYNLTSTIFQYPFGYLSDKTGKRKPFIILGILASGTTY 106
PYL + +G G L + + + FG +D+ G R + L LA+ Y
Sbjct: 32 PYLS---RKLGLDSIAFGYLQTTFGVLQLLGGPVFGRFADQRGARAA-LTLSFLAALALY 87
Query: 107 GLVALITSPIL----LLGLRAFQGALGASLAPAHSALISELSP--RIGSMFGFFGFVENL 160
L+A +SP L LL GAL +L PA +I++LS + G G +
Sbjct: 88 LLLAAASSPALPGVYLLFASRLPGALMHTL-PAAQMVITDLSAPEERPAALGRLGLCFGV 146
Query: 161 GFMAGNFAGGYIVKTLGMKMMFIITSLVSLIGILFLLKIKERGRAKAGGDRLIIVKEGRE 220
G + G+ GG +V G++ I+ +L +L+G + A D + G
Sbjct: 147 GVILGSLLGGTLVSAYGIQCPAILAALATLLGAVLSFTCIPASTKGAKTDAQAPLPGGPR 206
Query: 221 SDRVELKEIAFKKLMKGRLGIFYVAVLLAMIASGAVYATVSVYFEEKFGEEFV--GYL-- 276
+ ELK IA + IF V V + +G S+ + F E GYL
Sbjct: 207 ASVFELKGIASLLRLPDVPKIFLVKVA-SNCPTGLFMVMFSIISMDFFQLEAAKAGYLMS 265
Query: 277 -FGIDSLSAALSALIIGRLIDKYGEKLFFRLSLVGYIITFMGYALANSVIIMALISILSG 335
FG+ L L+IG+L + E++ S++ +I+ + A +SV L+ + G
Sbjct: 266 FFGL--LQMVTQGLVIGQLSSHFSEEVLLGASVLVFIVVGLAMAWMSSVFHFCLL--VPG 321
Query: 336 LKWTMLTNS--SSTYVARRVPTSERGQGMGLLNTMMTLGWVIGPLIGGILADNFGFAVML 393
L +++ T + + + + + V TS+ G +GL ++ L +GP +GG+L +FG V
Sbjct: 322 LVFSLCTLNVVTDSMLIKAVSTSDTGTMLGLCASVQPLLRTLGPTVGGLLYRSFGVPVFG 381
Query: 394 YSTVPILFLGFLLSFR 409
+ V I L L+ +R
Sbjct: 382 HVQVAINTLVLLVLWR 397
>gb|AAC17492.1| (AF030302) p45-BWR1A [Homo sapiens]
Length = 424
Score = 86.2 bits (210), Expect = 6e-16
Identities = 98/376 (26%), Positives = 167/376 (44%), Gaps = 23/376 (6%)
Query: 47 PYLGVYMKLIGGTMFLVGLLSVVYNLTSTIFQYPFGYLSDKTGKRKPFIILGILASGTTY 106
PYL + +G G L + + + FG +++ G R + L LA+ Y
Sbjct: 48 PYLS---RKLGLDSIAFGYLQTTFGVLQLLGGPVFGRFANQRGARAA-LTLSFLAALALY 103
Query: 107 GLVALITSPIL----LLGLRAFQGALGASLAPAHSALISELSP--RIGSMFGFFGFVENL 160
L+A +SP L LL GAL +L PA +I++LS + G G +
Sbjct: 104 LLLAAASSPALPGVYLLFASRLPGALMHTL-PAAQMVITDLSAPEERPAALGRLGLCFGV 162
Query: 161 GFMAGNFAGGYIVKTLGMKMMFIITSLVSLIGILFLLKIKERGRAKAGGDRLIIVKEGRE 220
G + G+ GG +V G++ I+ +L +L+G + A D + G
Sbjct: 163 GVILGSLLGGTLVSAYGIQCPAILAALATLLGAVLSFTCIPASTKGAKTDAQAPLPGGPR 222
Query: 221 SDRVELKEIAFKKLMKGRLGIFYVAVLLAMIASGAVYATVSVYFEEKFGEEFV--GYL-- 276
+ +LK IA + IF V V + +G S+ + F E GYL
Sbjct: 223 ASVFDLKAIASLLRLPDVPRIFLVKVA-SNCPTGLFMVMFSIISMDFFQLEAAQAGYLMS 281
Query: 277 -FGIDSLSAALSALIIGRLIDKYGEKLFFRLSLVGYIITFMGYALANSVIIMALISILSG 335
FG+ L L+IG+L + E++ R S++ +I+ + A +SV L+ + G
Sbjct: 282 FFGL--LQMVTQGLVIGQLSSHFSEEVLLRASVLVFIVVGLAMAWMSSVFHFCLL--VPG 337
Query: 336 LKWTMLTNS--SSTYVARRVPTSERGQGMGLLNTMMTLGWVIGPLIGGILADNFGFAVML 393
L +++ T + + + + + V TS+ G +GL ++ L +GP +GG+L +FG V
Sbjct: 338 LVFSLCTLNVVTDSMLIKAVSTSDTGTMLGLCASVQPLLRTLGPTVGGLLYRSFGVPVFG 397
Query: 394 YSTVPILFLGFLLSFR 409
+ V I L L+ +R
Sbjct: 398 HVQVAINTLVLLVLWR 413
>gb|AAC23505.1| (AF070479) efflux transporter like protein [Homo sapiens]
Length = 424
Score = 86.2 bits (210), Expect = 6e-16
Identities = 99/376 (26%), Positives = 166/376 (43%), Gaps = 23/376 (6%)
Query: 47 PYLGVYMKLIGGTMFLVGLLSVVYNLTSTIFQYPFGYLSDKTGKRKPFIILGILASGTTY 106
PYL + +G G L + + + FG +D+ G R + L LA+ Y
Sbjct: 48 PYLS---RKLGLDSIAFGYLQTTFGVLQLLGGPVFGRFADQRGARAA-LTLSFLAALALY 103
Query: 107 GLVALITSPIL----LLGLRAFQGALGASLAPAHSALISELSP--RIGSMFGFFGFVENL 160
L+A +SP L LL GAL +L PA +I++LS + G G +
Sbjct: 104 LLLAAASSPALPGVYLLFASRLPGALMHTL-PAAQMVITDLSAPEERPAALGRLGLCFGV 162
Query: 161 GFMAGNFAGGYIVKTLGMKMMFIITSLVSLIGILFLLKIKERGRAKAGGDRLIIVKEGRE 220
G + G+ GG +V G++ I+ +L +L+G + A D + G
Sbjct: 163 GVILGSLLGGTLVSAYGIQCPAILAALATLLGAVLSFTCIPASTKGAKTDAQAPLPGGPR 222
Query: 221 SDRVELKEIAFKKLMKGRLGIFYVAVLLAMIASGAVYATVSVYFEEKFGEEFV--GYL-- 276
+ ELK IA + IF V V + +G S+ + F E GYL
Sbjct: 223 ASVFELKGIASLLRLPDVPKIFLVKVA-SNCPTGLFMVMFSIISMDFFQLEAAKAGYLMS 281
Query: 277 -FGIDSLSAALSALIIGRLIDKYGEKLFFRLSLVGYIITFMGYALANSVIIMALISILSG 335
FG+ L L+IG+L + E++ S++ +I+ + A +SV L+ + G
Sbjct: 282 FFGL--LQMVTQGLVIGQLSSHFSEEVLLGASVLVFIVVGLAMAWMSSVFHFCLL--VPG 337
Query: 336 LKWTMLTNS--SSTYVARRVPTSERGQGMGLLNTMMTLGWVIGPLIGGILADNFGFAVML 393
L +++ T + + + + + V TS+ G +GL ++ L +GP +GG+L +FG V
Sbjct: 338 LVFSLCTLNVVTDSMLIKAVSTSDTGTMLGLCASVQPLLRTLGPTVGGLLYRSFGVPVFG 397
Query: 394 YSTVPILFLGFLLSFR 409
+ V I L L+ +R
Sbjct: 398 HVQVAINTLVLLVLWR 413
>gb|AAD10060.1| (AF113952) multidrug-efflux transporter [Campylobacter jejuni]
Length = 431
Score = 85.8 bits (209), Expect = 8e-16
Identities = 87/359 (24%), Positives = 153/359 (42%), Gaps = 24/359 (6%)
Query: 29 LMFAIGMFFADFAWGLGFPYLGVY-MKLIGGTMFLVGLLSVVYNLTSTIFQYPFGYLSDK 87
L F +G F F + P L +Y +KL G FLVGLL VY LT I Q PFG LSDK
Sbjct: 8 LSFIVGTRF--FGLFIVLPVLSLYALKLEGANEFLVGLLVGVYALTQMILQMPFGILSDK 65
Query: 88 TGKRKPFII-LGILASGTTYGLVALITSPILLLGLRAFQGALGASLAPAHSALISELSPR 146
G++K +I L I G+ A +LL + GA+GA S I+E
Sbjct: 66 IGRKKTMLIGLIIFIIGSLICSFAENIYTMLLGRMLQGAGAIGAVATAMISDFITE--EN 123
Query: 147 IGSMFGFFGFVENLGFMAGNFAGGYIVKTLGMKMMFIITSLVSLIGILFLLKIKERGRAK 206
G G L F A + G+ +F +++ +SL+ I+ L
Sbjct: 124 RGKAMAVMGSFIGLSFAASMVISPLMSAKWGLSSLFDLSAALSLLCIILLY--------- 174
Query: 207 AGGDRLIIVKEGRESDRVELKEIAFKKLMKGRLGIFYVAVLLAMIASGAVYATVSVYFEE 266
++ KE + + E K F + + L + + + + + ++ + +
Sbjct: 175 -----TVVPKENKITHENE-KTPFFHLIKQKNLALMNLTNFMQKMLMSIAFLSIPIILVK 228
Query: 267 K--FGEEFVGYLFGIDSLSAALSALIIGRLIDKYG-EKLFFRLSLVGYIITFMGYALANS 323
F + + ++ ++ ++ G L +K G K L +V +I++++ +A +NS
Sbjct: 229 HLGFASDKLWIVYSASMVAGFIAMGFAGSLGEKRGLAKQILLLGIVFFILSYLFFAFSNS 288
Query: 324 VIIMALISILSGLKWTMLTNSSSTYVARRVPTSERGQGMGLLNTMMTLGWVIGPLIGGI 382
+ + ++ + + + + ++ E+G +GL N G IG +IGGI
Sbjct: 289 IDFFIIAVVIFFIGFNLHEPIMQSCASKFCKVHEKGAALGLFNAFGYGGSFIGGIIGGI 347
>pir||D81282 probable efflux protein Cj1375 [imported] - Campylobacter jejuni
(strain NCTC 11168) >gi|6968809|emb|CAB73802.1|
(AL139078) putative efflux protein [Campylobacter
jejuni]
Length = 431
Score = 85.8 bits (209), Expect = 8e-16
Identities = 87/359 (24%), Positives = 153/359 (42%), Gaps = 24/359 (6%)
Query: 29 LMFAIGMFFADFAWGLGFPYLGVY-MKLIGGTMFLVGLLSVVYNLTSTIFQYPFGYLSDK 87
L F +G F F + P L +Y +KL G FLVGLL VY LT I Q PFG LSDK
Sbjct: 8 LSFIVGTRF--FGLFIVLPVLSLYALKLEGANEFLVGLLVGVYALTQMILQMPFGILSDK 65
Query: 88 TGKRKPFII-LGILASGTTYGLVALITSPILLLGLRAFQGALGASLAPAHSALISELSPR 146
G++K +I L I G+ A +LL + GA+GA S I+E
Sbjct: 66 IGRKKTMLIGLIIFIIGSLICSFAENIYTMLLGRMLQGAGAIGAVATAMISDFITE--EN 123
Query: 147 IGSMFGFFGFVENLGFMAGNFAGGYIVKTLGMKMMFIITSLVSLIGILFLLKIKERGRAK 206
G G L F A + G+ +F +++ +SL+ I+ L
Sbjct: 124 RGKAMAVMGSFIGLSFAASMVISPLMSAKWGLSSLFDLSAALSLLCIILLY--------- 174
Query: 207 AGGDRLIIVKEGRESDRVELKEIAFKKLMKGRLGIFYVAVLLAMIASGAVYATVSVYFEE 266
++ KE + + E K F + + L + + + + + ++ + +
Sbjct: 175 -----TVVPKENKITHENE-KTPFFHLIKQKNLALMNLTNFMQKMLMSIAFLSIPIILVK 228
Query: 267 K--FGEEFVGYLFGIDSLSAALSALIIGRLIDKYG-EKLFFRLSLVGYIITFMGYALANS 323
F + + ++ ++ ++ G L +K G K L +V +I++++ +A +NS
Sbjct: 229 HLGFASDKLWIVYSASMVAGFIAMGFAGSLGEKKGLAKQILLLGIVFFILSYLFFAFSNS 288
Query: 324 VIIMALISILSGLKWTMLTNSSSTYVARRVPTSERGQGMGLLNTMMTLGWVIGPLIGGI 382
+ + ++ + + + + ++ E+G +GL N G IG +IGGI
Sbjct: 289 IDFFIIAVVIFFIGFNLHEPIMQSCASKFCKVHEKGAALGLFNAFGYGGSFIGGIIGGI 347
>gb|AAD09860.1| (AF090987) drug efflux protein TetA [Agrobacterium tumefaciens]
Length = 394
Score = 85.4 bits (208), Expect = 1e-15
Identities = 97/349 (27%), Positives = 175/349 (49%), Gaps = 28/349 (8%)
Query: 43 GLGFPYL-GVYMKLIGG--TMFLVGLLSVVYNLTSTIFQYPFGYLSDKTGKRKPFIILGI 99
GL FP L + +++ GG FL G++ V+ + +F G LSD+ G+R P ++L +
Sbjct: 20 GLIFPILPDILVEVTGGGDIGFLYGVMLGVFAVMQFVFSPILGALSDRFGRR-PVLLLSL 78
Query: 100 LASGTTYGLVALITSP---ILLLGLRAFQGALGASLAPAHSALISELSP--RIGSMFGFF 154
+GT + + SP +L++G RA G A++A A SA I++++P + FG
Sbjct: 79 --AGTLLDYLVMAFSPLGWVLVVG-RAMAGITSANMAVA-SAYITDITPAEQRAQRFGTV 134
Query: 155 GFVENLGFMAGNFAGGYIVKTLGMKMMFIITSLVSLIGILFLLKIKERGRAKAGGDRLII 214
G V +LGF+ G GG ++ ++ F++ +L + + + L + R KAG +
Sbjct: 135 GAVMSLGFIIGPVIGG-VIGAWWLRAPFLVAALFNGLNLFVALFVLPESR-KAGPGKFAF 192
Query: 215 VKEGRESDRVELKEIAFKKLMKGRLGIFYVAVLLAMIASGAVYATVSV-YFEEKFGEEFV 273
+ + V L FK L L + V+V+ ++A A+ T+ V Y E+FG + V
Sbjct: 193 KELNPLAPLVWLWN--FKPL----LPLVTVSVVFGLVA--AIPGTIWVLYGAERFGWDSV 244
Query: 274 --GYLFGIDSLSAALS-ALIIGRLIDKYGEKLFFRLSLVGYIITFMGYALANSVIIMALI 330
G + +S AL+ A ++G L ++G+ + + ++ +M A AN + +
Sbjct: 245 HMGLSLSVFGVSGALAQAFLVGPLSRRFGDLGTLMIGVGFDMLAYMLMAFANQSWMGYAV 304
Query: 331 SILSGLKWTMLTNSSSTYVARRVPTSERGQGMGLLNTMMTLGWVIGPLI 379
+ L L + S V RV ++GQ G+L ++M+L +IGP++
Sbjct: 305 APLFALGGVAMPALQSL-VTSRVSDDQQGQLQGVLASLMSLAGIIGPVL 352
>pir||D64464 hypothetical protein MJ1317 - Methanococcus jannaschii
>gi|1591956|gb|AAB99324.1| (U67571) hypothetical protein
[Methanococcus jannaschii]
Length = 398
Score = 84.7 bits (206), Expect = 2e-15
Identities = 99/411 (24%), Positives = 166/411 (40%), Gaps = 33/411 (8%)
Query: 10 QGLQEKSGKIRKITMRKNILMFAIGMFFADFAWGLGFPYLGVYMKLIGGTMFLVGLLSVV 69
Q LQ+ + R+++ KN+ + F D + + P L + + +GG +GL+ +
Sbjct: 8 QNLQKNNENDRELS--KNVYLLGFTSFLNDMSSEMIMPILPMLITSVGGGSLSIGLVGGL 65
Query: 70 YNLTSTIFQYPFGYLSDKTGKRKPFIILGILASGTTYGLVALITSPILLLGLRAFQG--- 126
S I GY SDK KRK F++LG L S L+ L S LG F
Sbjct: 66 REFISNILMVLIGYCSDKVRKRKIFVVLGYLTSSMFKLLLGLSKS---WLGAVIFSSLER 122
Query: 127 -ALGASLAPAHSALISELSPR-IGSMFGFFGFVENLGFMAGNFAGGYIVKTL--GMKMMF 182
G AP A+ISE P+ +G FG + G + G+ + L +
Sbjct: 123 MGKGIRTAP-RDAIISESMPKTLGKGFGIQRAFDTAGAILGSTLSLLFILYLQYSFNQII 181
Query: 183 IITSLVSLIGILFLLKIKERGRAKAGGDRLIIVKEGRESDRVELKEIAFKKLMKG-RLGI 241
+I +++ + ++ L +KE K ++++ + + K L K +L I
Sbjct: 182 LIAAVIGFLTLIPLYFVKE--------------KPSPSNNKITFR-VGIKNLPKELKLFI 226
Query: 242 FYVAVLLAMIASGAVYATVSVYF----EEKFGEEFVGYLFGIDSLSAALSALIIGRLIDK 297
A+ S Y + F +EK L+ + ++ A ++ G L DK
Sbjct: 227 LISAIFTLSNFSYMFYILRAQEFLMIVDEKMAIIIPIALYILYNIFYATFSIPFGILSDK 286
Query: 298 YGEKLFFRLSLVGYIITFMGYALANSVIIMALISILSGLKWTMLTNSSSTYVARRVPTSE 357
G K + + Y I +G+A S + L+ L G+ + + + YV+
Sbjct: 287 IGRKSVLTIGYIVYGIVSLGFAYFISQKSLILLFALYGIAYALFAGNQKAYVSDLSSEDI 346
Query: 358 RGQGMGLLNTMMTLGWVIGPLIGGILADNFGFAVMLYSTVPILFLGFLLSF 408
R +GL T++ L + LI G L LY +V + G LL F
Sbjct: 347 RATALGLFYTVVGLTSLPASLIAGYLWKISPEMTFLYGSVLAIISGLLLLF 397
>emb|CAC11303.1| (AL445063) conserved hypothetical protein [Thermoplasma
acidophilum]
Length = 427
Score = 84.3 bits (205), Expect = 2e-15
Identities = 91/411 (22%), Positives = 178/411 (43%), Gaps = 51/411 (12%)
Query: 38 ADFAWGLGFPYLGVYMKL-IGGTMFLVGLLSVVYNLTSTIFQYPFGYLSDKTGKRKPFII 96
+ A G+ P + +++ + + +F VGL S V + S +G LSD KRK F++
Sbjct: 13 SSMASGITNPMIPLFVVVYLHSNVFFVGLASAVSSAASVPALILWGDLSDAVSKRKIFVL 72
Query: 97 LGILASGTTYGLVALITSPILLLGLRAFQGALGASLAPAHSALISELSPRI--GSMFGFF 154
+G + ++ + + S L + L + P + ++ E + R + F
Sbjct: 73 IGFFGAFVSFLPIVFVHSIYQYLAILITFQVLAMASVPVSTIMLLEQNDRSVWPQIISKF 132
Query: 155 GFVENLGFMAGNFAGGYIV----KTLGMKMMFIITSLVSLI-GILFLLKIKE------RG 203
V +G + G G ++ + ++I++S V LI GI+ L I E R
Sbjct: 133 SMVSGIGSVLGLGLGTALITFYYSPSDLPYVYIVSSAVYLIAGIMALRFIHEPRRILNRN 192
Query: 204 RAKAGGDRLII-----------------VKEGRESDRVELKEIAFKKLMKGRLGIFYVAV 246
+A R+I G DR + IA + IF+V
Sbjct: 193 AIQANTFRIIERPRYFPVAVIHYLRLNGKNNGHRLDRNLVLFIAMTAFLMFGFQIFFVPY 252
Query: 247 LLAMIASGAVYATVSVYFEEKFGEEFVGYLFGIDSLSAALSALIIGRLIDKYGEKLFFRL 306
+ +I GA + F+ Y+F +S + +S + GR++++ G K L
Sbjct: 253 PVMVIDFGANNTLI-----------FLMYMF--NSAFSTVSFIFSGRIVNRIGGKTSLFL 299
Query: 307 SLVGYIITFMGYAL-----ANSVIIMALISILSGLK--WTMLTNSSSTYVARRVPTSERG 359
++ I+ F +L + + I++ +SI S L W++++ S + YV++ RG
Sbjct: 300 AVTTRIMVFGLSSLIPNISSRDLAIISAVSIYSFLGGIWSIISVSQTNYVSKNATQQTRG 359
Query: 360 QGMGLLNTMMTLGWVIGPLIGGILADNFGFAVMLYSTVPILFLGFLLSFRI 410
+ +GL N+++ +G + G L+ G + FG+++ ++ +G ++ RI
Sbjct: 360 KAIGLYNSLLGVGQIFGGLVSGEVTTLFGYSIDYIMAAAVITIGMVIILRI 410
>pir||B70065 antibiotic resistance protein homolog ywoG - Bacillus subtilis
>gi|1684651|emb|CAB05383.1| (Z82987) unknown similar to
quinolon resistance protein NorA [Bacillus subtilis]
>gi|2636170|emb|CAB15662.1| (Z99122) similar to
antibiotic resistance protein [Bacillus subtilis]
Length = 396
Score = 83.1 bits (202), Expect = 5e-15
Identities = 89/389 (22%), Positives = 164/389 (41%), Gaps = 31/389 (7%)
Query: 28 ILMFAIGMFFADFAWGLGFPYLGVY-MKLIGGTMFLVGLLSVVYNLTSTIFQYPF-GYLS 85
I++ + +F F + L +Y ++ +GGT GLL ++ L S I PF G +
Sbjct: 13 IMVLLVNLFVFVFFYTF-LTVLPIYTLQELGGTESQGGLLISLF-LLSAIITRPFSGAIV 70
Query: 86 DKTGKRKPFIILGILASGTTYGLVALITSPI----LLLGLRAFQGALGASLAPAHSALIS 141
++ GK++ I+ S + L + + PI LLLGLR FQG + L A+ +
Sbjct: 71 ERFGKKRMAIV-----SMALFALSSFLYMPIHNFSLLLGLRFFQGIWFSILTTVTGAIAA 125
Query: 142 ELSP--RIGSMFGFFGFVENLGFMAGNFAGGYIVKTLGMKMMFIITSLVSLIGILFLLKI 199
++ P R G G+F NL G F G +++ + + F +L + G+L I
Sbjct: 126 DIIPAKRRGEGLGYFAMSMNLAMAIGPFLGLNLMRVVSFPVFFTAFALFMVAGLLVSFLI 185
Query: 200 KERGRAKAGGDRLIIVKEGRESDRVELKEIAFKKLMKGRLGIFYVAVLLAMIASGAVYAT 259
K V + ++S + KG L I V + ++ S V +
Sbjct: 186 K--------------VPQSKDSGTTVFRFAFSDMFEKGALKIATVGLFISFCYS-TVTSY 230
Query: 260 VSVYFEEKFGEEFVGYLFGIDSLSAALSALIIGRLIDKYGEKLFFRLSLVGYIITFMGYA 319
+SV+ + + GY F +++ ++ G+L DK G + S++ + + +
Sbjct: 231 LSVFAKSVDLSDISGYFFVCFAVTMMIARPFTGKLFDKVGPGIVIYPSILIFSVGLCMLS 290
Query: 320 LANSVIIMALISILSGLKWTMLTNSSSTYVARRVPTSERGQGMGLLNTMMTLGWVIGPLI 379
+S +++ L + GL + + T ++ P G T G +G +
Sbjct: 291 FTHSGLMLLLSGAVIGLGYGSIVPCMQTLAIQKSPAHRSGFATATFFTFFDSGIAVGSYV 350
Query: 380 GGILADNFGFAVMLYSTVPILFLGFLLSF 408
G+ + GF+ +Y T + L LL +
Sbjct: 351 FGLFVASAGFSA-IYLTAGLFVLIALLLY 378
>dbj|BAA36484.1| (AB019536) NorA [Staphylococcus aureus]
Length = 388
Score = 82.7 bits (201), Expect = 7e-15
Identities = 87/376 (23%), Positives = 159/376 (42%), Gaps = 38/376 (10%)
Query: 24 MRKNILMFAIGMFFADFAWGLGFPYLGVYMKLIGGTMFLVGLLSVVYNLTSTIFQYPFGY 83
M K I + +F GL P L VY+K +G T +GLL + L+ I G
Sbjct: 1 MNKQIFVLYFNIFLIFLGIGLVIPVLPVYLKDLGLTGSDLGLLVAAFALSQMIISPFGGT 60
Query: 84 LSDKTGKRKPFIILGILASGTTYGLVALITSPILLLGLRAFQGALGASLAPAHSALISEL 143
L+DK GK K I +G++ + + A+ + +L+ R G + P + LI+++
Sbjct: 61 LADKLGK-KLIICIGLILFSVSEFMFAVGHNFSVLMLSRVIGGMSAGMVMPGVTGLIADV 119
Query: 144 SP--RIGSMFGFFGFVENLGFMAGNFAGGYIVKTLGMKMMFIITSLVSLIGILFLLKIKE 201
SP + FG+ + N GF+ G GG++ + + +M F + ++ +
Sbjct: 120 SPSHQKAKNFGYMSAIINSGFILGPGIGGFMAE-VSHRMPFYFAGALGILAFIM------ 172
Query: 202 RGRAKAGGDRLIIVKEGRESDRVELKEIAFKKLMKGRLGIFYVAVLLAMIASGAVYATVS 261
++++ + ++S +++ + L K +F +L ++ + + A +
Sbjct: 173 ---------SVVLIHDPKKSTTSGFQKLEPQLLTKINWKVFITPAILTLVLAFGLSAFET 223
Query: 262 VYFEEKFGEEFVGYLFGIDSLSAALSALIIGRLIDKYGEKLFFRLSLVGYIITFMGYALA 321
+Y + V Y D A I G L Y F + +TF+ ++L
Sbjct: 224 LY--SLYTSYKVNY-SPKDISIAITGGGIFGALFQIY---FFDKFMKYFSELTFIAWSLI 277
Query: 322 NSVIIMALISILSGLKWTMLTNSSSTYVA------------RRVPTSERGQGMGLLNTMM 369
SVI++ L+ I G WT++ S ++ + +G GL +T
Sbjct: 278 YSVIVLVLLVIADGY-WTIMVISFVVFIGFDMIRPAITNYFSNIAGDRQGFAGGLNSTFT 336
Query: 370 TLGWVIGPLIGGILAD 385
++G IGPLI G L D
Sbjct: 337 SMGNFIGPLIAGALFD 352
>emb|CAA76069.1| (Y16103) tetracycline resistance efflux protein of class H
[Pasteurella haemolytica]
Length = 400
Score = 81.1 bits (197), Expect = 2e-14
Identities = 89/328 (27%), Positives = 150/328 (45%), Gaps = 30/328 (9%)
Query: 64 GLLSVVYNLTSTIFQYPFGYLSDKTGKRKPFIILGILASGTTYGLVALITSPILLLGLRA 123
G+L +Y IF G LSDK G RKP ++ +L + Y L+A T+ +L R
Sbjct: 44 GVLLALYATMQVIFAPILGRLSDKYG-RKPILLFSLLGAALDYLLMAFSTTLWMLYIGRI 102
Query: 124 FQGALGASLAPAHSALISELSPRIG--SMFGFFGFVENLGFMAGNFAGGYIVKTLGMKMM 181
G GA+ A SA+ S+++P FGF G +G + G GG ++ + M
Sbjct: 103 IAGITGATGAVCASAM-SDVTPAKNRTRYFGFLGGAFGVGLIIGPMLGG-LLGDISAHMP 160
Query: 182 FIITSLV-SLIGILFLLKIKERGRAKAGGDRLIIVKEGRESDRVELKEIAFKKLMKGRLG 240
FI ++ S++ IL LL +E + +A L+ + + FKK + L
Sbjct: 161 FIFAAISHSILLILSLLFFRETQKREA----LVANRTPENQTASNTVTVFFKKSLYFWLA 216
Query: 241 IFYVAVLLAMIASGAVYATVSVYFEE---KFGEEFVGYLFGI-DSLSAALSALIIGRLID 296
+++ L+ G + AT+ V F + + +G G+ L A++ G+L
Sbjct: 217 TYFIIQLI-----GQIPATIWVLFTQYRFDWNTTSIGMSLGVLGVLHIFFQAIVAGKLAQ 271
Query: 297 KYGEKLFFRLSLVGYIITFMGYALAN-----SVIIMALISILSGLKWTMLTNSSSTYVAR 351
K+GEK +S+ I MG L VI+ ALI + +G M + Y+++
Sbjct: 272 KWGEKTTIMISM---SIDMMGCLLLAWIGHVWVILPALICLAAG---GMGQPALQGYLSK 325
Query: 352 RVPTSERGQGMGLLNTMMTLGWVIGPLI 379
V + +G+ G L ++ + +IGPL+
Sbjct: 326 SVDDNAQGKLQGTLVSLTNITGIIGPLL 353
>pir||B71247 hypothetical protein PH0233 - Pyrococcus horikoshii
>gi|3256622|dbj|BAA29305.1| (AP000001) 387aa long
hypothetical protein [Pyrococcus horikoshii]
Length = 387
Score = 80.8 bits (196), Expect = 3e-14
Identities = 86/370 (23%), Positives = 158/370 (42%), Gaps = 25/370 (6%)
Query: 47 PYLGVYMKLIGGTMFLVGLLSVVYNLTSTIFQYPFGYLSDKTGKRKPFI---ILGILASG 103
P + Y +G FLVGL++ V + S + + GY+ D+ + ILGI+ SG
Sbjct: 24 PLISPYAITLGAEPFLVGLVAGVTSGVSLVSKLFGGYIGDRGYRFHAMFLGNILGII-SG 82
Query: 104 TTYGLVALITSPILLLGLRAFQGALGASLAPAHSALISELSP--RIGSMFGFFGFVENLG 161
Y + A+ S + RA G P+ + +L+P R+G G+ G + +LG
Sbjct: 83 VFYIISAMFHSIFIFAIGRAIHGVGMGIFFPSSLSSAVDLAPKGRVGEALGWRGMMFSLG 142
Query: 162 FMAGNFAGGYIVKTLGMKMMFIITSLVSLIGILFLLKI-KERGRAKAGGDRLIIVKEGRE 220
+ G GG++ G F++ L S+IG +F+L + +E G +K +
Sbjct: 143 NIIGPGIGGFVSDRFGFVSAFLLAILFSIIGAIFVLAVWREVGE----------IKFEKR 192
Query: 221 SDRVELKEIAFKKLMKGRLGIFYVAVLLAMIASGAVYATVSVYFEEKFGEEFVGYLFGID 280
+R +E+ + L +F+++V SG V ++Y G+ G I
Sbjct: 193 EERSGYRELIRVFFITACLSLFFISVAY----SGVVTFLPALYKVSGLGQGIFGLYMMIM 248
Query: 281 SLSAALSALIIGRLIDKYGEKLFFRLSLVGYIITFMGYALANSVIIMALISILSGLKWTM 340
+S+ L+ ++ GR D++G R+ + +I++ L++ +SG + +
Sbjct: 249 GVSSFLTRVVGGRSADRFGPIPVARIGVGMILISYALLVKFKFPPHSYLVAFISGAGFGL 308
Query: 341 LTNSSSTYVARRVPTSERGQGMGLLNTMMTLGWVIGPLIGGILADNFGFAVMLYSTVPIL 400
+ ++P R G + LG + G + G +A G+ P++
Sbjct: 309 TYPALQYMALAKLPGRIRTMGSSIYTMFFDLGMLSGQVGLGYVAQLSGYE----GVFPVV 364
Query: 401 FLGFLLSFRI 410
L LLS I
Sbjct: 365 ALLPLLSLLI 374
>sp|P51564|TCR8_PASMU TETRACYCLINE RESISTANCE PROTEIN, CLASS H (TETA(H))
>gi|392873|gb|AAC43250.1| (U00792) tetracycline
resistance protein [Pasteurella multocida]
Length = 400
Score = 80.4 bits (195), Expect = 4e-14
Identities = 90/328 (27%), Positives = 151/328 (45%), Gaps = 30/328 (9%)
Query: 64 GLLSVVYNLTSTIFQYPFGYLSDKTGKRKPFIILGILASGTTYGLVALITSPILLLGLRA 123
G+L +Y IF G LSDK G RKP ++ +L + Y L+A T+ +L R
Sbjct: 44 GVLLALYATMQVIFAPILGRLSDKYG-RKPILLFSLLGAALDYLLMAFSTTLWMLYIGRI 102
Query: 124 FQGALGASLAPAHSALISELSPRIG--SMFGFFGFVENLGFMAGNFAGGYIVKTLGMKMM 181
G GA+ A SA+ S+++P FGF G V +G + G GG ++ + M
Sbjct: 103 IAGITGATGAVCASAM-SDVTPAKNRTRYFGFLGGVFGVGLIIGPMLGG-LLGDISAHMP 160
Query: 182 FIITSLV-SLIGILFLLKIKERGRAKAGGDRLIIVKEGRESDRVELKEIAFKKLMKGRLG 240
FI ++ S++ IL LL +E + +A L+ + + FKK + L
Sbjct: 161 FIFAAISHSILLILSLLFFRETQKREA----LVANRTPENQTASNTVTVFFKKSLYFWLA 216
Query: 241 IFYVAVLLAMIASGAVYATVSVYFEE---KFGEEFVGY-LFGIDSLSAALSALIIGRLID 296
+++ L+ G + AT+ V F + + +G L + L A++ G+L
Sbjct: 217 TYFIIQLI-----GQIPATIWVLFTQYRFDWNTTSIGMSLAVLGVLHIFFQAIVAGKLAQ 271
Query: 297 KYGEKLFFRLSLVGYIITFMGYALAN-----SVIIMALISILSGLKWTMLTNSSSTYVAR 351
K+GEK +S+ I MG L VI+ ALI + +G M + Y+++
Sbjct: 272 KWGEKTTIMISM---SIDMMGCLLLAWIGHVWVILPALICLAAG---GMGQPALQGYLSK 325
Query: 352 RVPTSERGQGMGLLNTMMTLGWVIGPLI 379
V + +G+ G L ++ + +IGPL+
Sbjct: 326 SVDDNAQGKLQGTLVSLTNITGIIGPLL 353
>pir||G71118 hypothetical protein PH0718 - Pyrococcus horikoshii
>gi|3257126|dbj|BAA29809.1| (AP000003) 398aa long
hypothetical protein [Pyrococcus horikoshii]
Length = 398
Score = 80.4 bits (195), Expect = 4e-14
Identities = 104/399 (26%), Positives = 176/399 (44%), Gaps = 38/399 (9%)
Query: 14 EKSGKIRKITMRKNILMFAIGMFFADFAWGLGFPYLGVYMK--LIGGTMFLVGLLSVVYN 71
EK KI I+ N+ + + F D + + P + Y+ L G + ++ ++ +
Sbjct: 5 EKERKIAGISW--NVFLLGLVSFLNDMSSEMIAPIVPTYLTDILKMGKLASGSIMGLIES 62
Query: 72 LTSTIFQYPFGYLSDKTGKRKPFIILGILASGTTYGLVALITSPILLLGLRAFQG-ALGA 130
L+S +F+ FGY+SD KRK F+ LG L S G +AL S L LR G
Sbjct: 63 LSS-LFKVIFGYISDVFRKRKTFVALGYLLSTIAKGALALTHSWWDFLTLRILDRIGKGI 121
Query: 131 SLAPAHSALISELSPR--IGSMFGFFGFVENLGFMAGNFAGGYIV-------KTLGMKMM 181
AP ALI+E S + G FGF ++ LG + G ++ K L + +
Sbjct: 122 RTAP-RDALIAESSEKGKSGKSFGFHRMMDTLGAVTGPLVAVGLLALLSKYPKELAYRYI 180
Query: 182 FIITSLVSLIGILFLL-KIKERGRAKAGGDRLIIVKEGRESDRVELKEIAFKKLMKGRLG 240
F+I+++ IG+L ++ +K+RG IVK+ ++KEI+ L L
Sbjct: 181 FLISAIPGAIGVLIVIFLVKDRGG---------IVKK-------KIKEIS--SLKSPHLR 222
Query: 241 IFYVAVLLAMIASGAVYATVSVYFEEKFGEEFVGYLF-GIDSLSAALSALIIGRLIDKYG 299
F V +A + + YA +E F G F + ++ AL+A IG DK G
Sbjct: 223 AFLAVVAIAALGRYS-YAFTLWKVKELGYSIFQGLEFYALFNVIYALAAYPIGSYSDKVG 281
Query: 300 EKLFFRLSLVGYIITFMGYALANSVIIMALISILSGLKWTMLTNSSSTYVARRVPTSERG 359
+K + + +A + S+ ++ L IL G+ + Y+A E+G
Sbjct: 282 KKKIITTGFGIAGLASLLFAYSKSLAMLMLAFILYGVYMAIEDTIPRAYMADLAKEYEKG 341
Query: 360 QGMGLLNTMMTLGWVIGPLIGGILADNFGFAV-MLYSTV 397
+G+ +T+ + +I G L + + LY++V
Sbjct: 342 TIIGMYHTVFGIFVFPASIIVGYLWQTYSLEIGFLYASV 380
>pir||H75515 tetracycline-efflux transporter - Deinococcus radiodurans (strain
R1) >gi|6458158|gb|AAF10051.1|AE001906_7 (AE001906)
tetracycline-efflux transporter [Deinococcus
radiodurans]
Length = 407
Score = 80.0 bits (194), Expect = 5e-14
Identities = 91/333 (27%), Positives = 157/333 (46%), Gaps = 27/333 (8%)
Query: 57 GGTMFLVGLLSVVYNLTSTIFQYPFGYLSDKTGKRKPFIILGILASGTTYGLVALITSPI 116
GG F +G+L+ Y IF G LSD+ G+R P ++L + +G + L SP
Sbjct: 45 GGARF-IGVLTAAYAAMQFIFAPILGTLSDRFGRR-PVLLLSL--AGMVLDYLLLFFSPN 100
Query: 117 L--LLGLRAFQGALGASLAPAHSALISELSPRIGSM-FGFFGFVENLGFMAGNFAGGYIV 173
L LL R G GASL A++ + +P + FG G +GF+ G GG++
Sbjct: 101 LWWLLVGRLIAGVTGASLTVANAYIADVTAPEDRAKNFGRLGATWGVGFILGPMLGGWLG 160
Query: 174 KTLGMKMMFI----ITSLVSLIGILFLLK-IKERGRAKAGGDRLIIVKEGRESDRVELKE 228
+ G++ F+ +T+L L G+L L + + R AGG L + L+
Sbjct: 161 EH-GLRAPFLFAAGLTALNFLYGLLVLPESLPPEKRGAAGGGTL--------NPFTPLRA 211
Query: 229 IAFKKLMKGRLGIFYVAVLLA--MIASGAVYATVSVYFEEKFGEEFVGYLFGIDSLSAAL 286
+ L++G L + +V + LA +I S V T V ++G+ L+A +
Sbjct: 212 LTEYPLLRG-LTLTFVLLGLAGQVIVSTWVLYTEGVLRWSPLQNGIAFAVYGL--LTAGV 268
Query: 287 SALIIGRLIDKYGEKLFFRLSLVGYIITFMGYALANSVIIMALISILSGLKWTMLTNSSS 346
A +I I ++GE+ LV + F+ ++A S ++ L S++ G + +
Sbjct: 269 QAGLISPFIARFGERRTIMTGLVASTLEFVVLSVARSAPVLYL-SLVVGALGGLAQPAMQ 327
Query: 347 TYVARRVPTSERGQGMGLLNTMMTLGWVIGPLI 379
++R+V E+G+ MG + ++ +L V GPL+
Sbjct: 328 GLISRQVGEQEQGRVMGAITSLNSLVGVFGPLL 360
>gb|AAK40865.1| Multidrug resistance related protein [Sulfolobus solfataricus]
Length = 393
Score = 79.6 bits (193), Expect = 6e-14
Identities = 95/413 (23%), Positives = 178/413 (43%), Gaps = 44/413 (10%)
Query: 11 GLQEKSGKIRKITMRKNILMFAIGMFFADFAWGLGFPYLGVYMKLIGGTMFLVGLLSVVY 70
GL++ +I I K +L F++ + + FA+ L Y + M + T F +G++ +
Sbjct: 2 GLKQTLKEIYYIVADKRLLYFSLSLGISTFAYSLLTYYFPIIMTNLDITTFTIGIIYSII 61
Query: 71 NLTSTIFQYPFGYLSDKTGKRKPFIILGILASGTTYGLVALITSPILLLGLRAFQGALG- 129
+ +F P G + DK G K + L L + + L+ + + ++ L F+ +
Sbjct: 62 SFLYVVFNIPLGAIVDKIGS-KNAVTLSALMAVPLFLLMGTLNPLLFIISLVIFESVIRI 120
Query: 130 ASLAPAHSALISELSPRIGSMFGFFGFVENLGFMAGNFAGGYIVKTLGMKMMF-IITSLV 188
+ AH +++ + G FG F + ++ G GGY+++ ++F II L
Sbjct: 121 VNSLGAHRFMLNYTN--AGKAFGVFSLITSILAAIGIMLGGYLLQHSVSTLLFTIIAVLF 178
Query: 189 SLIGILFLLKIKERGRAKAGGDRLIIVKEGRESDRVELK---EIAFKKLMKGRLGIFYVA 245
+ GI+ L++ ++ ++VE+K + FK L + + + Y
Sbjct: 179 GISGIIRFLELP------------------KDENKVEVKRSLRLGFKYLKEDKKLLLY-- 218
Query: 246 VLLAMIASGAVYAT--VSVYFEEK--FGEEFVGYLFGIDSLSAALSALIIGRLIDKYGEK 301
+L+++++SG T V++YF + FVG L+ +L A L+ ++ K
Sbjct: 219 LLVSILSSGLSLETYYVTIYFVKDLLLPLTFVGVLYSSYALIMAFLPLLFSVILSKRSNF 278
Query: 302 LFFRLSLVGYIITFMGYALANSVIIMALISILSGLKWTMLTNSSSTY---VARRVPTSE- 357
+ + + F L +V I+ L+ WT++ S VA+ V E
Sbjct: 279 KNLSILIFSNSVIFFLVPLFTNVYILFLLF----YAWTVIVAMESIVDYNVAQSVTKPEI 334
Query: 358 RGQGMGLLNTMMTLGWVIGPLIGGILADNFGFAVMLYSTVPILFLGFLLSFRI 410
RG + L++T + + V I G+L LYS FLG L F I
Sbjct: 335 RGTQVALISTFVRIFSVFYNAIVGLLFQ----ITPLYSFYFTGFLGILAIFTI 383
>emb|CAB57751.1| (Y18930) hypothetical protein [Sulfolobus solfataricus]
Length = 393
Score = 79.6 bits (193), Expect = 6e-14
Identities = 95/413 (23%), Positives = 178/413 (43%), Gaps = 44/413 (10%)
Query: 11 GLQEKSGKIRKITMRKNILMFAIGMFFADFAWGLGFPYLGVYMKLIGGTMFLVGLLSVVY 70
GL++ +I I K +L F++ + + FA+ L Y + M + T F +G++ +
Sbjct: 2 GLKQTLKEIYYIVADKRLLYFSLSLGISTFAYSLLTYYFPIIMTNLDITTFTIGIIYSII 61
Query: 71 NLTSTIFQYPFGYLSDKTGKRKPFIILGILASGTTYGLVALITSPILLLGLRAFQGALG- 129
+ +F P G + DK G K + L L + + L+ + + ++ L F+ +
Sbjct: 62 SFLYVVFNIPLGAIVDKIGS-KNAVTLSALMAVPLFLLMGTLNPLLFIISLVIFESVIRI 120
Query: 130 ASLAPAHSALISELSPRIGSMFGFFGFVENLGFMAGNFAGGYIVKTLGMKMMF-IITSLV 188
+ AH +++ + G FG F + ++ G GGY+++ ++F II L
Sbjct: 121 VNSLGAHRFMLNYTN--AGKAFGVFSLITSILAAIGIMLGGYLLQHSVSTLLFTIIAVLF 178
Query: 189 SLIGILFLLKIKERGRAKAGGDRLIIVKEGRESDRVELK---EIAFKKLMKGRLGIFYVA 245
+ GI+ L++ ++ ++VE+K + FK L + + + Y
Sbjct: 179 GISGIIRFLELP------------------KDENKVEVKRSLRLGFKYLKEDKKLLLY-- 218
Query: 246 VLLAMIASGAVYAT--VSVYFEEK--FGEEFVGYLFGIDSLSAALSALIIGRLIDKYGEK 301
+L+++++SG T V++YF + FVG L+ +L A L+ ++ K
Sbjct: 219 LLVSILSSGLSLETYYVTIYFVKDLLLPLTFVGVLYSSYALIMAFLPLLFSVILSKRSNF 278
Query: 302 LFFRLSLVGYIITFMGYALANSVIIMALISILSGLKWTMLTNSSSTY---VARRVPTSE- 357
+ + + F L +V I+ L+ WT++ S VA+ V E
Sbjct: 279 KNLSILIFSNSVIFFLVPLFTNVYILFLLF----YAWTVIVAMESIVDYNVAQSVTKPEI 334
Query: 358 RGQGMGLLNTMMTLGWVIGPLIGGILADNFGFAVMLYSTVPILFLGFLLSFRI 410
RG + L++T + + V I G+L LYS FLG L F I
Sbjct: 335 RGTQVALISTFVRIFSVFYNAIVGLLFQ----ITPLYSFYFTGFLGILAIFTI 383
>pir||D83117 probable MFS transporter PA4233 [imported] - Pseudomonas aeruginosa
(strain PAO1) >gi|9950449|gb|AAG07621.1|AE004840_7
(AE004840) probable MFS transporter [Pseudomonas
aeruginosa]
Length = 462
Score = 79.2 bits (192), Expect = 8e-14
Identities = 92/399 (23%), Positives = 174/399 (43%), Gaps = 45/399 (11%)
Query: 29 LMFA---IGMFFADFAWGLGFPYLGVY-MKLIGGTMFLVGLLSVVYNLTSTIFQYPFGYL 84
L+FA +GMF P L Y L G T L+GL Y LT I Q PFG +
Sbjct: 22 LVFAFRMLGMFMV-------LPVLATYGQDLAGATPALIGLAIGAYGLTQAILQIPFGTI 74
Query: 85 SDKTGKRKPFIILGILASGTTYGLVALITSPILLLGLRAFQGALGASLAPAHSALISELS 144
SD+ G R+P I++G+L L A S ++ R QGA +++ A AL+S+L+
Sbjct: 75 SDRIG-RRPVIVVGLLIFAAGAALAANADSIWGVIAGRVLQGA--GAISAAVMALLSDLT 131
Query: 145 --PRIGSMFGFFGFVENLGFMAGNFAGGYIVKTLGMKMMFIITSLVSLIGILFLLKIKER 202
G + F G + G+ +F T+ ++L+G+L +L +
Sbjct: 132 REQHRTKAMAMIGMSIGVSFAVAMVLGPVLTHLFGLHGLFWFTAGMALVGLLLILFFVPQ 191
Query: 203 GRAKAGGDRLIIVKEGRESDRVELKEIAFKKLMKGRLGIFYVAVLLAMIASGAVYATVSV 262
D + +E + + L + L++ GI +L A++ + V +++
Sbjct: 192 ------PDHMTQHRESSVARQALLPTLKHGDLLRLDAGIL---ILHAILMASFVALPLAL 242
Query: 263 YFEEKFGEEFVGYLFGIDSLSAALSALIIG-----RLIDKYGEKLFFRLSLVGYIITFMG 317
E +E +++ L+AL++G I +K + L G + T +
Sbjct: 243 VHEGGLPKEQHWWVY--------LTALLVGFFGMVPFIIYAEKKRRMKRVLTGAVATLLA 294
Query: 318 YAL-----ANSVIIMALISILSGLKWTMLTNSSSTYVARRVPTSERGQGMGLLNTMMTLG 372
L +S+ ++ + +++ + +L S + V++ P +G MG+ +T LG
Sbjct: 295 CELFFLVFGHSLAMLVVGTVVFFTAFNLLEASLPSLVSKVSPAGGKGTAMGVYSTSQFLG 354
Query: 373 WVIGPLIGGILADNFGFAVMLY--STVPILFLGFLLSFR 409
+G ++GG + + G +++ + + L+L ++ R
Sbjct: 355 AALGGILGGWMFQHGGLSMVFIGCAVLAALWLAIAVTMR 393
>emb|CAA75663.1| (Y15510) tetracycline resistance efflux protein of class H
[Pasteurella multocida]
Length = 400
Score = 78.8 bits (191), Expect = 1e-13
Identities = 89/328 (27%), Positives = 150/328 (45%), Gaps = 30/328 (9%)
Query: 64 GLLSVVYNLTSTIFQYPFGYLSDKTGKRKPFIILGILASGTTYGLVALITSPILLLGLRA 123
G+L +Y IF G LSDK G RKP ++ +L + Y L+A T+ +L R
Sbjct: 44 GVLLALYATMQVIFAPILGRLSDKYG-RKPILLFSLLGAALDYLLMAFSTTLWMLYIGRI 102
Query: 124 FQGALGASLAPAHSALISELSPRIG--SMFGFFGFVENLGFMAGNFAGGYIVKTLGMKMM 181
G GA+ A SA+ S+++P FGF G +G + G GG ++ + M
Sbjct: 103 IAGITGATGAVCASAM-SDVTPAKNRTRYFGFLGGAFGVGLIIGPMLGG-LLGDISAHMP 160
Query: 182 FIITSLV-SLIGILFLLKIKERGRAKAGGDRLIIVKEGRESDRVELKEIAFKKLMKGRLG 240
FI ++ S++ IL LL +E + +A L+ + + FKK + L
Sbjct: 161 FIFAAISHSILLILSLLFFRETQKREA----LVANRTPENQTASNTVTVFFKKSLYFWLA 216
Query: 241 IFYVAVLLAMIASGAVYATVSVYFEE---KFGEEFVGY-LFGIDSLSAALSALIIGRLID 296
+++ L+ G + AT+ V F + + +G L + L A++ G+L
Sbjct: 217 TYFIIQLI-----GQIPATIWVLFTQYRFDWNTTSIGMSLAVLGVLHIFFQAIVAGKLAQ 271
Query: 297 KYGEKLFFRLSLVGYIITFMGYALAN-----SVIIMALISILSGLKWTMLTNSSSTYVAR 351
K+GEK +S+ I MG L VI+ ALI + +G M + Y+++
Sbjct: 272 KWGEKTTIMISM---SIDMMGCLLLAWIGHVWVILPALICLAAG---GMGQPALQGYLSK 325
Query: 352 RVPTSERGQGMGLLNTMMTLGWVIGPLI 379
V + +G+ G L ++ + +IGPL+
Sbjct: 326 SVDDNAQGKLQGTLVSLTNITGIIGPLL 353
>emb|CAC08220.1| (AJ245947) tetracycline resistance efflux protein [Pasteurella
aerogenes]
Length = 392
Score = 78.8 bits (191), Expect = 1e-13
Identities = 89/328 (27%), Positives = 150/328 (45%), Gaps = 30/328 (9%)
Query: 64 GLLSVVYNLTSTIFQYPFGYLSDKTGKRKPFIILGILASGTTYGLVALITSPILLLGLRA 123
G+L +Y IF G LSDK G RKP ++ +L + Y L+A T+ +L R
Sbjct: 44 GVLLALYATMQVIFAPILGRLSDKYG-RKPILLFSLLGAALDYLLMAFSTTLWMLYIGRI 102
Query: 124 FQGALGASLAPAHSALISELSPRIG--SMFGFFGFVENLGFMAGNFAGGYIVKTLGMKMM 181
G GA+ A SA+ S+++P FGF G +G + G GG ++ + M
Sbjct: 103 IAGITGATGAVCASAM-SDVTPAKNRTRYFGFLGGAFGVGLIIGPMLGG-LLGDISAHMP 160
Query: 182 FIITSLV-SLIGILFLLKIKERGRAKAGGDRLIIVKEGRESDRVELKEIAFKKLMKGRLG 240
FI ++ S++ IL LL +E + +A L+ + + FKK + L
Sbjct: 161 FIFAAISHSILLILSLLFFRETQKREA----LVANRTPENQTASNTVTVFFKKSLYFWLA 216
Query: 241 IFYVAVLLAMIASGAVYATVSVYFEE---KFGEEFVGY-LFGIDSLSAALSALIIGRLID 296
+++ L+ G + AT+ V F + + +G L + L A++ G+L
Sbjct: 217 TYFIIQLI-----GQIPATIWVLFTQYRFDWNTTSIGMSLAVLGVLHIFFQAIVAGKLAQ 271
Query: 297 KYGEKLFFRLSLVGYIITFMGYALAN-----SVIIMALISILSGLKWTMLTNSSSTYVAR 351
K+GEK +S+ I MG L VI+ ALI + +G M + Y+++
Sbjct: 272 KWGEKTTIMISM---SIDMMGCLLLAWIGHVWVILPALICLAAG---GMGQPALQGYLSK 325
Query: 352 RVPTSERGQGMGLLNTMMTLGWVIGPLI 379
V + +G+ G L ++ + +IGPL+
Sbjct: 326 SVDDNAQGKLQGTLVSLTNITGIIGPLL 353
>dbj|BAA32780.1| (AB012084) ITM [Mus musculus] >gi|11191803|emb|CAC16401.1|
(AJ276505) tumor suppressing subtransferable candidate 5
[Mus musculus domesticus]
Length = 406
Score = 78.4 bits (190), Expect = 1e-13
Identities = 88/375 (23%), Positives = 165/375 (43%), Gaps = 23/375 (6%)
Query: 47 PYLGVYMKLIGGTMFLVGLLSVVYNLTSTIFQYPFGYLSDKTGKRKPFIILGILASGTTY 106
PYL + +G G L + + + FG +D+ G R + L LA+ Y
Sbjct: 32 PYLS---RTLGLDSVSFGYLQTTFGVLQLLGGPVFGRFADQCGARAA-LSLSFLAASALY 87
Query: 107 GLVALITSPILLLGLRAFQGALGASLA---PAHSALISELSPRIG--SMFGFFGFVENLG 161
L+ SP L F + ++L PA +I++L+ + G G +G
Sbjct: 88 LLLVASCSPALPGVFLLFASRIPSALMHTLPAAQMVITDLTAPTERPAALGRLGLCFGIG 147
Query: 162 FMAGNFAGGYIVKTLGMKMMFIITSLVSLIGILFLLKIKERGRAKAGGDRLIIVKEGRES 221
+ G+ GG + G++ I+ +V+L+G + +A + G ++
Sbjct: 148 IIFGSLLGGTLNTAYGIQCPAILAFVVTLLGAVLSFTCVPATTKEASVQSA--PQGGTKA 205
Query: 222 DRVELKEIAFKKLMKGRLGIFYVAVLLAMIASGAVYATVSVYFEEKFGEEFV--GYL--- 276
+LK I L+ L +F V V+ + SG S+ + F E GYL
Sbjct: 206 SVFDLKAITRLLLLPRVLPVFLVKVISGL-PSGLFLVMFSIISMDFFQLEAAQAGYLMSF 264
Query: 277 FGIDSLSAALSALIIGRLIDKYGEKLFFRLSLVGYIITFMGYALANSVIIMALISILSGL 336
FGI L + L+IGRL + E+ R S++ + + +G AL +SV+ ++ GL
Sbjct: 265 FGI--LQMMIQGLVIGRLSTHFPEEALLRSSVLVFAVVGLGMALMSSVLHFCF--LMPGL 320
Query: 337 KWTMLTNS--SSTYVARRVPTSERGQGMGLLNTMMTLGWVIGPLIGGILADNFGFAVMLY 394
+++ T + + + + + V S+ G +GL ++ L +GP +GG+L ++G + +
Sbjct: 321 VFSLCTLNVVTDSMLTKAVSASDTGTMLGLSASVQPLTRTLGPTLGGLLYRSYGVPIFGH 380
Query: 395 STVPILFLGFLLSFR 409
+ + L L+ ++
Sbjct: 381 VQLMVNLLVLLVLWK 395
>pir||B75211 multidrug resistance protein PAB0146 - Pyrococcus abyssi (strain
Orsay) >gi|5457646|emb|CAB49137.1| (AJ248283) MULTIDRUG
RESISTANCE PROTEIN [Pyrococcus abyssi]
Length = 387
Score = 78.4 bits (190), Expect = 1e-13
Identities = 91/379 (24%), Positives = 154/379 (40%), Gaps = 35/379 (9%)
Query: 24 MRKNILMFAIGMFFADFAWGLGFPYLGVYMKLIGGTMFLVGLLSVVYNLTSTIFQYPFGY 83
M KN+ FF + P + Y +G FLVG+++ V + S + GY
Sbjct: 1 MLKNLWFLNFSTFFFFLGISILNPLISPYAITLGAKPFLVGVVAGVASGISLFSKLIGGY 60
Query: 84 LSDKTGKRKPFIILGILA--SGTTYGLVALITSPILLLGLRAFQGALGASLAPAHSALIS 141
+ DK + + +L SG Y AL S ++ RA G P+ +
Sbjct: 61 IGDKGYRFHAMFLGNVLGIFSGLLYIASALSGSIMVFALGRAVHGFAMGIFFPSSLSSAV 120
Query: 142 ELSP--RIGSMFGFFGFVENLGFMAGNFAGGYIVKTLGMKMMFIITSLVSLIGILFLLKI 199
+L+P R+G G+ G + +LG + G GG+I G M F + + S++G +F+L +
Sbjct: 121 DLAPKGRVGEALGWRGMMFSLGNIVGPAIGGFISDKFGFGMAFFSSIVFSVLGAIFVLLV 180
Query: 200 -KERGRAKAGGDRLIIVKEGRESDRVELKEIAFKKLMKGRLGIFYVAVLLAMIASGAVYA 258
+E G +K + + +E+ + L +F++ +M SG V
Sbjct: 181 WREVGE----------IKVDKHEEHSGYRELLKPFFISACLSLFFI----SMAYSGVVTF 226
Query: 259 TVSVYFEEKFGEEFVGYLFGIDSLSAALSALIIGRLIDKYGEKLFFRLSLVGYIITFMGY 318
++Y G+ G I L++ ++ GR DK G R+ + G F+ Y
Sbjct: 227 LPALYKVSGLGQSVFGLYMMIMGLASFFMRVVGGRSADKLGPIPVIRVGVSG---IFLAY 283
Query: 319 AL-------ANSVIIMALISILSGLKWTMLTNSSSTYVA-RRVPTSERGQGMGLLNTMMT 370
L NS I A+ GL L Y+A ++P R G +
Sbjct: 284 LLLLKFKFPPNSYISAAISGAGFGLSLPAL-----QYMALAKLPGKIRTMGSSIYTMFFD 338
Query: 371 LGWVIGPLIGGILADNFGF 389
LG + G + G++A G+
Sbjct: 339 LGMLSGQVGLGLVAQVRGY 357
>gi|10957271 tetracycline antiporter protein [Salmonella typhi]
>gi|7739619|gb|AAF68936.1|AF223162_7 (AF223162)
tetracycline antiporter protein [Salmonella typhi]
>gi|7800324|gb|AAF69920.1|AF250878_81 (AF250878)
tetracycline antiporter protein [Salmonella typhi]
Length = 401
Score = 77.6 bits (188), Expect = 2e-13
Identities = 91/347 (26%), Positives = 161/347 (46%), Gaps = 38/347 (10%)
Query: 64 GLLSVVYNLTSTIFQYPFGYLSDKTGKRKPFIILGILASGTTYGLVALITSPILLLGLRA 123
G+L +Y L IF G +SD+ G+R P ++L ++ + Y L+A ++ +L R
Sbjct: 44 GVLLALYALMQVIFAPWLGKMSDRFGRR-PVLLLSLIGASLDYLLLAFSSALWMLYLGRL 102
Query: 124 FQGALGASLAPAHSAL--ISELSPRIGSMFGFFGFVENLGFMAGNFAGGYIVKTLGMKMM 181
G GA+ A A S + + S R+ FG+ G LG +AG GG+ +
Sbjct: 103 LSGITGATGAVAASVIADTTSASQRV-KWFGWLGASFGLGLIAGPIIGGF-AGEISPHSP 160
Query: 182 FIITSLVSLIGILFLL-KIKERGRAKAGGDRLIIVKEGRESDRVELKEIAFKKLMKGRLG 240
F I +L++++ L ++ +E + D + V+ S + L K M L
Sbjct: 161 FFIAALLNIVAFLVVMFWFRETKNTRDNTDTEVGVETQSNSVYITL-----FKTMPILLI 215
Query: 241 IFYVAVLLAMIASGAVYATVSVYF-EEKFG--EEFVGY-LFGIDSLSAALSALIIGRLID 296
I++ A L+ G + ATV V F E +FG VG+ L G+ L + A + GR+
Sbjct: 216 IYFSAQLI-----GQIPATVWVLFTENRFGWNSMMVGFSLAGLGLLHSVFQAFVAGRIAT 270
Query: 297 KYGEKLFFRLSLVGYIITFMGYA----LANSVIIMALISILSGLKWTMLTNSSSTYVARR 352
K+GEK L+G+I +A ++ ++ ++ +L+G + + ++ +
Sbjct: 271 KWGEK---TAVLLGFIADSSAFAFLAFISEGWLVFPVLILLAG--GGIALPALQGVMSIQ 325
Query: 353 VPTSERGQGMGLLNTMMTLGWVIGPLIGGILADNFGFAVMLYSTVPI 399
+ ++G GLL ++ VIGPL+ FAV+ ++PI
Sbjct: 326 TKSHQQGALQGLLVSLTNATGVIGPLL---------FAVIYNHSLPI 363
>gi|9507600 tetracycline resistance protein [Plasmid R100]
>gi|135547|sp|P02980|TCR2_ECOLI TETRACYCLINE RESISTANCE
PROTEIN, CLASS B (TETA(B)) (METAL-TETRACYCLINE/H+
ANTIPORTER) >gi|72835|pir||YTECT0 tetracycline
resistance protein - Escherichia coli transposon Tn10
>gi|5103199|dbj|BAA78835.1| (AP000342) tetracycline
resistance protein [Plasmid R100]
>gi|5738089|gb|AAD50247.1|AF162223_6 (AF162223) TetA
[Shigella flexneri]
>gi|8489188|gb|AAF75607.1|AF217317_10 (AF217317) Tn10
tetracycline resistance protein TetA [Filamentous phage
cloning vector fd-tet]
Length = 401
Score = 76.9 bits (186), Expect = 4e-13
Identities = 90/346 (26%), Positives = 157/346 (45%), Gaps = 36/346 (10%)
Query: 64 GLLSVVYNLTSTIFQYPFGYLSDKTGKRKPFIILGILASGTTYGLVALITSPILLLGLRA 123
G+L +Y L IF G +SD+ G+R P ++L ++ + Y L+A ++ +L R
Sbjct: 44 GVLLALYALMQVIFAPWLGKMSDRFGRR-PVLLLSLIGASLDYLLLAFSSALWMLYLGRL 102
Query: 124 FQGALGASLAPAHSAL--ISELSPRIGSMFGFFGFVENLGFMAGNFAGGYIVKTLGMKMM 181
G GA+ A A S + + S R+ FG+ G LG +AG GG+ +
Sbjct: 103 LSGITGATGAVAASVIADTTSASQRV-KWFGWLGASFGLGLIAGPIIGGFAGEISPHSPF 161
Query: 182 FIITSLVSLIGILFLLKIKERGRAKAGGDRLIIVKEGRESDRVELKEIAFKKLMKGRLGI 241
FI L + ++ + +E + D + V+ S + L K M L I
Sbjct: 162 FIAALLNIVTFLVVMFWFRETKNTRDNTDTEVGVETQSNSVYITL-----FKTMPILLII 216
Query: 242 FYVAVLLAMIASGAVYATVSVYF-EEKFG--EEFVGY-LFGIDSLSAALSALIIGRLIDK 297
++ A L+ G + ATV V F E +FG VG+ L G+ L + A + GR+ K
Sbjct: 217 YFSAQLI-----GQIPATVWVLFTENRFGWNSMMVGFSLAGLGLLHSVFQAFVAGRIATK 271
Query: 298 YGEKLFFRLSLVGYIITFMGYA----LANSVIIMALISILSGLKWTMLTNSSSTYVARRV 353
+GEK L+G+I +A ++ ++ ++ +L+G + + ++ +
Sbjct: 272 WGEK---TAVLLGFIADSSAFAFLAFISEGWLVFPVLILLAG--GGIALPALQGVMSIQT 326
Query: 354 PTSERGQGMGLLNTMMTLGWVIGPLIGGILADNFGFAVMLYSTVPI 399
+ ++G GLL ++ VIGPL+ FAV+ ++PI
Sbjct: 327 KSHQQGALQGLLVSLTNATGVIGPLL---------FAVIYNHSLPI 363
>pir||E71116 hypothetical protein PH0700 - Pyrococcus horikoshii
>gi|3257108|dbj|BAA29791.1| (AP000003) 439aa long
hypothetical protein [Pyrococcus horikoshii]
Length = 439
Score = 76.9 bits (186), Expect = 4e-13
Identities = 98/371 (26%), Positives = 160/371 (42%), Gaps = 27/371 (7%)
Query: 57 GGTMFLVGLLSVVYNLTSTIFQYPFGYLSDKTGKRKPFIILGILASGTTYGLVALITSPI 116
GG VG S +L S + +G LSD+ G+RK +ILGI S + L+ + S
Sbjct: 56 GGGSTEVGYASGFGSLASMVGGMIWGRLSDRLGRRKILMILGIFGSSISVLLMGISLSIK 115
Query: 117 LLLGLRAFQGALGASLAPAHSALISELSPR--IGSMFGFFGFVENLGFMAGNFAGGYIVK 174
+ L F A+ P +LIS R I G F + G++ G G ++
Sbjct: 116 WTIILNIFYMFFLAATIPLPLSLISREFRRYEINKAIGRFNELGGWGWVVGLILGFTLIT 175
Query: 175 TLGMKMMFIITSLVSLIGILFLL-KIKE-----RGRAKAGGDRLIIVKEGRESDRVELKE 228
+ ++ + L+ ++ +F+ KIKE +G K G I R RV L
Sbjct: 176 LVNPRITTLTLGLLGVLSAVFMRSKIKEVPIHIKG-IKINGTPSIFTFHPR---RVSLTR 231
Query: 229 IAFKKLMKGRLGIFYVAVLLAMIASGAVYATVSVYFEEKFGEEFVGYLFGIDSLSAALSA 288
++ G L +V+ L + S V + + K + YL I S + SA
Sbjct: 232 ---PQVQDGMLKTMFVSSFLFWLGSMLVLTQYPIIAKSKGFDGKALYLVSISS--SVTSA 286
Query: 289 L--------IIGRLIDKYGEKLFFR-LSLVGYIITFMGYALANSVIIMALISILSGLKWT 339
L IIG + Y E L R L L+G + + + + M + SIL G W
Sbjct: 287 LMYQRVANSIIGSGMLNYVEGLILRGLGLMGLLFSTLLPSNMFLPASMLMYSIL-GYSWA 345
Query: 340 MLTNSSSTYVARRVPTSERGQGMGLLNTMMTLGWVIGPLIGGILADNFGFAVMLYSTVPI 399
+++ S+S+ ++ R P ++RG+ G N + + G +IG L G L + G V + +
Sbjct: 346 IVSISTSSIISSRTPENKRGRIFGSYNFICSSGAIIGSLGSGYLINKMGIQVDFMIGLWL 405
Query: 400 LFLGFLLSFRI 410
+ G +S +I
Sbjct: 406 ILPGIYMSSKI 416
>pir||B81080 drug resistance translocase family protein NMB1461 [imported] -
Neisseria meningitidis (group B strain MD58)
>gi|7226703|gb|AAF41820.1| (AE002496) drug resistance
translocase family protein [Neisseria meningitidis MC58]
Length = 461
Score = 76.5 bits (185), Expect = 5e-13
Identities = 89/367 (24%), Positives = 160/367 (43%), Gaps = 31/367 (8%)
Query: 33 IGMFFADFAWGLGFPYLGVYMKLIGGT---MFLVGLLSVVYNLTSTIFQYPFGYLSDKTG 89
+GMF L P L VY + G LVGL +Y LT + Q P G SDK G
Sbjct: 30 LGMF-------LVLPVLAVYAASLPGAEGNKTLVGLAMGIYGLTQALLQLPLGIASDKFG 82
Query: 90 KRKPFIILGILASGTTYGLVALITSPILLLGLRAFQGALGASLAPAHSALISELSP---R 146
++K I G++ L A + +L+ RA QGA +++ A +AL+++L+ R
Sbjct: 83 RKKT-IYAGLVVFAAGSFLAAAADTLPMLVAARAIQGA--GAVSAAVTALLADLTRDGVR 139
Query: 147 IGSMFGFFGFVENLGFMAGNFAGGYIVKTLGMKMMFIITSLVSLIGILFLLKIKERGRAK 206
+M G L F I +G++ +F++T ++++I I + +
Sbjct: 140 TRAM-AMIGLSIGLTFSVSLVVAPVIADAVGVRGLFMLTGILTVISIGVVAWMTPDPEVS 198
Query: 207 AGGDRLIIVKEGRESDRVELKEIAF-KKLMKGRLGIFYVAVLLAMIASGAVYATVSVYFE 265
+ E ++ + E+ ++L+ GIF + + + +A + E
Sbjct: 199 K-------LHEDTQAQPSRIGEVLKNRRLLTLDFGIFALHAAQMALFTALPFAMTQLGLE 251
Query: 266 EKFGEEFVGYLFG-IDSLSAALSALIIGRLIDKYGEKLFFRLSLVGYIITFMGYALA-NS 323
+ + + YL I L + +I+G +K K F L +V +G S
Sbjct: 252 KI--QHWKVYLPSTITGLVVMVPLIIVGETRNKL--KQVFVLGIVCIAAAQLGLLSGMRS 307
Query: 324 VIIMALISILSGLKWTMLTNSSSTYVARRVPTSERGQGMGLLNTMMTLGWVIGPLIGGIL 383
V ++ ++ + + +L S + V++ P+ +G MG+ NTM +LG G GG+L
Sbjct: 308 VGLITAYLVVYFIGFNVLEASLPSMVSKIAPSDLKGTAMGVYNTMQSLGLFAGGAAGGLL 367
Query: 384 ADNFGFA 390
+GF+
Sbjct: 368 FQKYGFS 374
>pir||G75306 drug transport protein - Deinococcus radiodurans (strain R1)
>gi|6459969|gb|AAF11718.1|AE002050_4 (AE002050) drug
transport protein [Deinococcus radiodurans]
Length = 441
Score = 76.5 bits (185), Expect = 5e-13
Identities = 103/408 (25%), Positives = 177/408 (43%), Gaps = 48/408 (11%)
Query: 25 RKNILMFAIGMFFADFAWGLGFPYLGVYMKLIGGTMFLVGLLSVVYNLTSTIFQYPFGYL 84
R I++F + +F A + FP +G + +G T +G S Y+L IF +G
Sbjct: 41 RTKIILF-LTIFIAMLGLSVLFPIIGPLGRQLGLTPAQIGWFSTSYSLMQFIFSPIWGNR 99
Query: 85 SDKTGKRKPFIILGILASGTTYGL------------VALITSPILLLGLRAFQGALGASL 132
S+ G R+P +++G++ ++GL +AL T LL+G R G ++
Sbjct: 100 SEHHG-RRPTLLMGLVGFSVSFGLFGLFAQLGMNGGLALGTLFALLVGTRIIGGIFSSAT 158
Query: 133 APAHSALISELS---PRIGSMFGFFGFVENLGFMAGNFAGGYIVKTLGMKMMFIITSLVS 189
P A+++++S R SM G G LG + G GG + + ++ L
Sbjct: 159 LPTAQAMMADISSEDDRAASM-GLIGAAFGLGVVFGPAIGGLLSGISLVAPVYFSAGLGL 217
Query: 190 LIGILFLLKIKERGRAKAGGDRLIIVKEGRESDRVELKEIAFKKLMKGRLGIFYVAVLLA 249
L + E G R V DR L L +G + +F A L
Sbjct: 218 FTAALAYFMVPE--TRHPGQTRTATV------DRRSL-------LSRGGIPLFLAASALT 262
Query: 250 MIASGAVYATVSVYFEEKF----GE--EFVGYLFGIDSLSAALSALIIGRLIDKYGEKL- 302
+AS + T+S Y ++ GE + VG + I + L+AL+ G I +KL
Sbjct: 263 TLASVGMEQTISFYVQDVMKLDPGETAKTVGKMLAIFGI---LAALVQGGAIRPLSKKLP 319
Query: 303 FFRLSLVGYIITFMGYALANSVI----IMALISILSGLKWTMLTNSSSTYVARRVPTSER 358
L LVG +I G L + I A ++++ G+ +L+ + S ++ V +
Sbjct: 320 PTPLILVGLVIMAAGMFLLPQMATYWPITAALALI-GVGSAILSPTLSAALSLSVGKDGQ 378
Query: 359 GQGMGLLNTMMTLGWVIGPLIGGILADNFGFAVMLYSTVPILFLGFLL 406
G GL ++ + LG ++GPL+G L + G ++ IL + F++
Sbjct: 379 GAVAGLNSSALALGRMVGPLLGTNLYQHVGHGAPYIASGSILAVLFVV 426
>pir||B75044 hypothetical protein PAB0885 - Pyrococcus abyssi (strain Orsay)
>gi|5458760|emb|CAB50247.1| (AJ248287) hypothetical
protein [Pyrococcus abyssi]
Length = 440
Score = 76.1 bits (184), Expect = 7e-13
Identities = 110/410 (26%), Positives = 177/410 (42%), Gaps = 47/410 (11%)
Query: 22 ITMRKNILMFAIGMFFADFAWGLGFPYLGVYMKLIGGTMFLVGLLSVVYNLTSTIFQYPF 81
+ ++K F + F F+ G+ P + + + GGT +G S + +L S I +
Sbjct: 22 LKVKKRGKWFYSFILFKVFSGGMA-PLVPILIVNEGGTPTEIGYTSGLGSLASMIGGVIW 80
Query: 82 GYLSDKTGKRKPFIILGILASGTTYGLVALITSPILLLGLRAFQGALGASLAPAHSALIS 141
G LSDK G+RK F+ LGI S + L+++ S L+ L A+ P ++IS
Sbjct: 81 GRLSDKLGRRKIFMSLGIFGSTISVILMSVSLSIKSLIFLNILYMFFLAATIPLPISIIS 140
Query: 142 ------ELSPRIGSM--FGFFGFVENL--GFMAGNFAGGYIVKTLGMKMMFIITSLVSLI 191
E++ IG G +G+V L GF NFA I LG+ + I++
Sbjct: 141 REFRKYEINEAIGKFNKLGGWGWVGGLILGFALINFANPRIA-ILGLGALGILS------ 193
Query: 192 GILFLLKIKE----RGRAKAGGDRLIIVKEGRESDRVELKEIAFKKLMKGRLGIFYVAVL 247
GIL + +IKE R + G + + ++ KL L I +++
Sbjct: 194 GILTIKRIKEVPIHPSRFRVNG-----IIPSLFTFHPRKITLSTPKLRDEILRIVFISSF 248
Query: 248 LAMIASGAVYATVSVYFEEKFGEEFVGYLFGIDSLSAALSAL--------IIGRLIDKYG 299
L I S V +EK + Y I S + SAL I+G I Y
Sbjct: 249 LFWIGSMLALTQFPVLAKEKGLDGETLYFVSISS--SVTSALTYQRVANSIVGIGILNYV 306
Query: 300 EKLFFR-LSLVGYIITFMGYALANSVIIMALISILS--GLKWTMLTNSSSTYVARRVPTS 356
L R L L G + L + ++A I + S G W M++ S+S+ ++ R +
Sbjct: 307 NGLILRSLGLAGLLFVV---PLPSKTFLLASILVYSILGYSWAMISISTSSIISARSSEN 363
Query: 357 ERGQGMGLLNTMMTLGWVIGPLIGGILADNFG----FAVMLYSTVPILFL 402
RG+ G N + + G +IG L G LA+N G A+ L +P +++
Sbjct: 364 TRGRIFGSYNLVCSSGAIIGSLGSGYLANNIGMQGDLAIGLSLMIPAIYV 413
>dbj|BAB06930.1| (AP001518) multidrug resistance protein [Bacillus halodurans]
Length = 388
Score = 76.1 bits (184), Expect = 7e-13
Identities = 86/356 (24%), Positives = 155/356 (43%), Gaps = 17/356 (4%)
Query: 39 DFAWGLGFPYLGVYMKLIGGT-MFLVGLLSVVYNLTSTIFQYPFGYLSDKTGKRKPFIIL 97
+ +G+ PY +Y+ G +GL+ ++ S + + G LSD+ G++K ++
Sbjct: 2 NIGFGMVVPYFAIYLGTYTGLDPVSIGLIVGTTSIGSLVGGFLGGTLSDQFGRKKIMLVS 61
Query: 98 GILASGTTYGLVALITSPILLLGLRAFQGALGASLAPAHSALISELSPRIGSM--FGFFG 155
++AS G + L +LL+ L G + P AL+++ + M F
Sbjct: 62 LVVASAIYAGFM-LQDYALLLVCLTLVMGFCTSFFEPCAKALMADFTESKKRMKAFSLRY 120
Query: 156 FVENLGFMAGNFAGGYIVKTLGMKMMFIITSLVSLIGILFLLKIKERGRAKAGGDRLIIV 215
N+GF G G T ++ FI+ S + L LFL + +A G + I +
Sbjct: 121 IGANIGFAIGPLIGIVAGVTASSRLPFIVVSTILLAYALFL-----QWLFRAFGVQEISI 175
Query: 216 KEGRESDRVELKEIAFKKLMKGR-LGIFYVAVLLAMIASGAVYATVSVYFEEKF--GEEF 272
E + V L AFK + R L +F LLA + G +S YFE +F G +
Sbjct: 176 ---GEKEHVNLTG-AFKAIQSDRVLLLFLFGGLLATVVHGQFSVILSQYFELEFQSGLAY 231
Query: 273 VGYLFGIDSLSAALSALIIGRLIDKYGEKLFFRLSLVGYIITFMGYALANSVIIMALISI 332
+ L+ + S + + + +++++ + + + + +G+A + + + L I
Sbjct: 232 LMLLWSVHSGVIVICGIPLVKVMERLSPLRAIVIGSLFFAVGVIGFAFSFNFMTFCLAMI 291
Query: 333 LSGLKWTMLTNSSSTYVARRVPTSERGQGMGLLNTMMTLGWVIGPLIGGILADNFG 388
+ + L + + V P RG G LN +LG IGP + GIL +FG
Sbjct: 292 VFTIGEMFLIPAEYSIVDEITPNHMRGTYYGSLN-FTSLGSFIGPWLSGILLVHFG 346
>gb|AAB82728.1| (AF028739) multi-membrane spanning polyspecific transporter [Mus
musculus]
Length = 406
Score = 74.5 bits (180), Expect = 2e-12
Identities = 87/375 (23%), Positives = 162/375 (43%), Gaps = 23/375 (6%)
Query: 47 PYLGVYMKLIGGTMFLVGLLSVVYNLTSTIFQYPFGYLSDKTGKRKPFIILGILASGTTY 106
PYL + +G G L + + + FG +D+ G R + L LA Y
Sbjct: 32 PYLS---RTLGLDSVSFGYLQTTFGVLQLLGGPVFGRFADQCGARAA-LSLSFLAGSALY 87
Query: 107 GLVALITSPILLLGLRAFQGALGASLA---PAHSALISELSPRIG--SMFGFFGFVENLG 161
L+ SP L F + ++L PA +I++L+ + G G +G
Sbjct: 88 LLLVASCSPALPGVFLLFASRIPSALMHTLPAAQMVITDLTAPTERPAALGRLGLCFGIG 147
Query: 162 FMAGNFAGGYIVKTLGMKMMFIITSLVSLIGILFLLKIKERGRAKAGGDRLIIVKEGRES 221
+ G+ GG + G++ I+ +V+L+ + +A + G +
Sbjct: 148 IIFGSLLGGTLNTAYGIQCPAILAFVVTLLRAVLSFTCVPATTKEASVQSA--PQGGTKG 205
Query: 222 DRVELKEIAFKKLMKGRLGIFYVAVLLAMIASGAVYATVSVYFEEKFGEEFV--GYL--- 276
+LK I L+ L +F V V+ + SG S+ + F E GYL
Sbjct: 206 SVFDLKAITRLLLLPRVLPVFLVKVISGL-PSGLFLVMFSIISMDFFQLEAAQAGYLMSF 264
Query: 277 FGIDSLSAALSALIIGRLIDKYGEKLFFRLSLVGYIITFMGYALANSVIIMALISILSGL 336
FGI L + L+IGRL + E+ R S++ + + +G AL +SV+ ++ GL
Sbjct: 265 FGI--LQMMIQGLVIGRLSTHFPEEALLRSSVLVFAVVGLGMALMSSVLHFCF--LMPGL 320
Query: 337 KWTMLTNS--SSTYVARRVPTSERGQGMGLLNTMMTLGWVIGPLIGGILADNFGFAVMLY 394
+++ T + + + + + V S+ G +GL ++ L +GP +GG+L ++G + +
Sbjct: 321 VFSLCTLNVVTDSMLTKAVSASDTGTMLGLSASVQPLTRTLGPTLGGLLYRSYGVPIFGH 380
Query: 395 STVPILFLGFLLSFR 409
+ + L L+ ++
Sbjct: 381 VQLMVNLLVLLVLWK 395
>gi|10955433 TetA protein [Escherichia coli] >gi|43701|emb|CAA23880.1| (V00611)
coding sequence [Escherichia coli]
>gi|154847|gb|AAB59094.1| (J01830) tetracycline
resistance protein (tetA) [Transposon Tn10]
>gi|5327032|emb|CAB46266.1| (AJ247373) tetracyclin
resistance protein [Cloning vector pYanni5]
>gi|8919961|emb|CAB96429.1| (AJ277653) TetA protein
[Escherichia coli]
Length = 401
Score = 74.1 bits (179), Expect = 3e-12
Identities = 85/323 (26%), Positives = 145/323 (44%), Gaps = 21/323 (6%)
Query: 64 GLLSVVYNLTSTIFQYPFGYLSDKTGKRKPFIILGILASGTTYGLVALITSPILLLGLRA 123
G+L +Y L IF G +SD+ G+R P ++L ++ + Y L+A ++ +L R
Sbjct: 44 GVLLALYALMQVIFAPWLGKMSDRFGRR-PVLLLSLIGASLDYLLLAFSSALWMLYLGRL 102
Query: 124 FQGALGASLAPAHSAL--ISELSPRIGSMFGFFGFVENLGFMAGNFAGGYIVKTLGMKMM 181
G GA+ A A S + + S R+ FG+ G LG +AG GG+ +
Sbjct: 103 LSGITGATGAVAASVIADTTSASQRV-KWFGWLGASFGLGLIAGPIIGGFAGEISPHSPF 161
Query: 182 FIITSLVSLIGILFLLKIKERGRAKAGGDRLIIVKEGRESDRVELKEIAFKKLMKGRLGI 241
FI L + ++ + +E + D + V+ S + L K M L I
Sbjct: 162 FIAALLNIVTFLVVMFWFRETKNTRDNTDTEVGVETQSNSVYITL-----FKTMPILLII 216
Query: 242 FYVAVLLAMIASGAVYATVSVYF-EEKFG--EEFVGY-LFGIDSLSAALSALIIGRLIDK 297
++ A L+ G + ATV V F E +FG VG+ L G+ L + A + GR+ K
Sbjct: 217 YFSAQLI-----GQIPATVWVLFTENRFGWNSMMVGFSLAGLGLLHSVFQAFVAGRIATK 271
Query: 298 YGEKLFFRLSLVGYIITFMGYA-LANSVIIMALISILSGLKWTMLTNSSSTYVARRVPTS 356
+GEK L + F A ++ + ++ +L+G + + ++ + +
Sbjct: 272 WGEKTAVLLEFIADSSAFAFLAFISEGWLDFPVLILLAG--GGIALPALQGVMSIQTKSH 329
Query: 357 ERGQGMGLLNTMMTLGWVIGPLI 379
E+G GLL ++ VIGPL+
Sbjct: 330 EQGALQGLLVSLTNATGVIGPLL 352
>sp|P33449|BMR1_BACSU MULTIDRUG RESISTANCE PROTEIN 1 (MULTIDRUG-EFFLUX TRANSPORTER 1)
>gi|80337|pir||A39705 multidrug-efflux transporter bmr -
Bacillus subtilis >gi|142606|gb|AAA22277.1| (M33768)
multidrug-resistance protein (BMR) [Bacillus subtilis]
>gi|409287|gb|AAB81539.1| (L25604) multidrug-efflux
transporter [Bacillus subtilis]
>gi|1303946|dbj|BAA12601.1| (D84432) Bmr [Bacillus
subtilis] >gi|2634835|emb|CAB14332.1| (Z99116)
multidrug-efflux transporter [Bacillus subtilis]
Length = 389
Score = 74.1 bits (179), Expect = 3e-12
Identities = 73/368 (19%), Positives = 155/368 (41%), Gaps = 22/368 (5%)
Query: 25 RKNILMFAI--GMFFADFAWGLGFPYLGVYMKLIGGTMFLVGLLSVVYNLTSTIFQYPFG 82
+KNI + + +F A GL P M + + VG + + +T I G
Sbjct: 3 KKNITLTILLTNLFIAFLGIGLVIPVTPTIMNELHLSGTAVGYMVACFAITQLIVSPIAG 62
Query: 83 YLSDKTGKRKPFIILGILASGTTYGLVALITSPILLLGLRAFQGALGASLAPAHSALISE 142
D+ G RK I++G+L + L + + +L R G + P +A I++
Sbjct: 63 RWVDRFG-RKIMIVIGLLFFSVSEFLFGIGKTVEMLFISRMLGGISAPFIMPGVTAFIAD 121
Query: 143 LSP--RIGSMFGFFGFVENLGFMAGNFAGGYIVKTLGMKMMFIITSLVSLIGILFLLKIK 200
++ G+ + GF+ G GG++ + F + L IL +L ++
Sbjct: 122 ITTIKTRPKALGYMSAAISTGFIIGPGIGGFLAEVHSRLPFFFAAAFALLAAILSILTLR 181
Query: 201 ERGRAKAGGDRLIIVKEGRESDRVELKEIAFKKLMKGRLGIFYVAVLLAMIASGAVYATV 260
E R E+ ++ ++ FK++ I ++ +L++ + +
Sbjct: 182 EPER-------------NPENQEIKGQKTGFKRIFAPMYFIAFLIILISSFGLASFESLF 228
Query: 261 SVYFEEKFG---EEFVGYLFGIDSLSAALSALIIGRLIDKYGEKLFFRLSLVGYIITFMG 317
+++ + KFG + + G + A ++ R +GE R SL+
Sbjct: 229 ALFVDHKFGFTASDIAIMITGGAIVGAITQVVLFDRFTRWFGEIHLIRYSLILSTSLVFL 288
Query: 318 YALANSVIIMALISILSGLKWTMLTNSSSTYVARRVPTSERGQGMGLLNTMMTLGWVIGP 377
+S + + L+++ + + ++ + +TY+++ + +E+G G+ + ++G V GP
Sbjct: 289 LTTVHSYVAILLVTVTVFVGFDLMRPAVTTYLSK-IAGNEQGFAGGMNSMFTSIGNVFGP 347
Query: 378 LIGGILAD 385
+IGG+L D
Sbjct: 348 IIGGMLFD 355
>gi|6679180 organic cationic transporter-like 2 [Mus musculus]
>gi|2921451|gb|AAC04788.1| (AF037065) organic cation
transporter-like protein 2 [Mus musculus]
Length = 409
Score = 73.7 bits (178), Expect = 4e-12
Identities = 86/375 (22%), Positives = 164/375 (42%), Gaps = 24/375 (6%)
Query: 47 PYLGVYMKLIGGTMFLVGLLSVVYNLTSTIFQYPFGYLSDKTGKRKPFIILGILASGTTY 106
PYL + +G G L + + + FG +++ G R + L LA+ Y
Sbjct: 36 PYLS---RTLGLDSVSFGYLQTTFGVLQLLGGPVFGRFANQCGARAA-LSLSFLAASALY 91
Query: 107 GLVALITSPILLLGLRAFQGALGASLA---PAHSALISELSPRIG--SMFGFFGFVENLG 161
L+ SP L F + ++L PA +I++L+ + G G +G
Sbjct: 92 LLLVASCSPALPGVFLLFASRIPSALMHTIPAAQMVITDLTAPTERPAALGRLGLCFGIG 151
Query: 162 FMAGNFAGGYIVKTLGMKMMFIITSLVSLIGILFLLKIKERGRAKAGGDRLIIVKEGRES 221
M G+ GG + G++ I+ +V+L+G + +A + G ++
Sbjct: 152 IMFGSLLGGTLNTAYGIQCPAILAFVVTLLGAVLSFTCVPATTKEASVQSA--PQGGTKA 209
Query: 222 DRVELKEIAFKKLMKGRLGIFYVAVLLAMIASGAVYATVSVYFEEKFGEEFV--GYL--- 276
+LK I L+ L +F + + + SG S+ + F E GYL
Sbjct: 210 SVFDLKAITRLLLLPRVLPVFLS--VFSGLPSGLFLVMFSIISMDFFQLEAAQAGYLMSF 267
Query: 277 FGIDSLSAALSALIIGRLIDKYGEKLFFRLSLVGYIITFMGYALANSVIIMALISILSGL 336
FGI L + L+IGRL + E+ R S++ + + +G AL +SV+ ++ GL
Sbjct: 268 FGI--LQMMIQGLVIGRLSTHFPEEALLRSSVLVFAVVGLGMALMSSVLHFCF--LMPGL 323
Query: 337 KWTMLTNS--SSTYVARRVPTSERGQGMGLLNTMMTLGWVIGPLIGGILADNFGFAVMLY 394
+++ T + + + + + V S+ G +GL ++ L +GP +GG+L ++G + +
Sbjct: 324 VFSLCTLNVVTDSMLTKAVSASDTGTMLGLSASVQPLTRTLGPTLGGLLYRSYGVPIFGH 383
Query: 395 STVPILFLGFLLSFR 409
+ + L L+ ++
Sbjct: 384 VQLMVNLLVLLVLWK 398
>pir||A72413 conserved hypothetical protein - Thermotoga maritima (strain MSB8)
>gi|4980623|gb|AAD35224.1|AE001699_1 (AE001699)
conserved hypothetical protein [Thermotoga maritima]
Length = 384
Score = 73.0 bits (176), Expect = 6e-12
Identities = 99/395 (25%), Positives = 170/395 (42%), Gaps = 37/395 (9%)
Query: 28 ILMFAIGMFFADFAWGLGFPYLGVYMKLIGGTMFLVGLLSVVYNLTSTIFQYPFGYLSDK 87
I++ + FAD + +G +MK +G + +G + LT F+ G LSDK
Sbjct: 10 IVLLGLVSLFADVTYEGARSIIGPFMKTLGASAAALGFAVGLGELTGYAFRLISGILSDK 69
Query: 88 TGKRKPFIILGILASGTTYGLVALI----TSPILLLGLRAFQGALGASLAPAHSALISEL 143
T K F ILG + +A T+ +L++ R F AL PA L+S
Sbjct: 70 TRKYWLFTILGYAINLFAVPALAFAGNWQTALVLIIAER-FGKAL---RTPARDVLLSFA 125
Query: 144 SPRI--GSMFGFFGFVENLGFMAGNFAGGY-IVKTLGMKMMFIITSLVSLIGILFLLKIK 200
S + G FG ++ +G + G A + + + F I + +L+ ++ LL
Sbjct: 126 SEEVGMGKGFGIHEALDQIGAILGPLALTFALAFEKSYRFCFFILLIPALVAMVLLL--- 182
Query: 201 ERGRAKAGGDRLIIVKEGRES--DRVELKEIAFKKLMKGRLGIFYVAVLLAMIASGAVYA 258
A+ L +K+ ++S DR G+ FY+A++ + + A +
Sbjct: 183 ---TARITFPALQEMKKKKDSPVDR-----------NLGKTYWFYLAIVSMVAFAFADFP 228
Query: 259 TVSVYFE--EKFGEEFVGYLFGIDSLSAALSALIIGRLIDKYGEKLFFRLSLVGYIITFM 316
++ + + E + FV + + A++AL+ G L DK G F L+ + +F
Sbjct: 229 IIAYHMKSFEVAKDFFVPATYSLAMAVDAVAALVFGHLFDKKG---FVALAYAVLLSSFF 285
Query: 317 G-YALANSVIIMALISILSGLKWTMLTNSSSTYVARRVPTSERGQGMGLLNTMMTLGWVI 375
+ +NS ++ IL G+ + VA+ VP +RG G+ T+ + W
Sbjct: 286 PVLSFSNSFPLIFAGVILWGIGMGAQESIMRAVVAKIVPAEKRGFAYGMFFTVYGVFWFF 345
Query: 376 GPLIGGILADNFGFAVMLYSTVPILFLGFLLSFRI 410
G I G L D F ++L+S V I F LL R+
Sbjct: 346 GSWIMGTLYDINRFYLILFSFV-IQFAAALLLLRM 379
>pir||C55220 msyB homolog, pbpD 5'-region - Bacillus subtilis (fragment)
>gi|520535|gb|AAA64942.1| (U11882) unknown [Bacillus
subtilis]
Length = 256
Score = 71.8 bits (173), Expect = 1e-11
Identities = 56/244 (22%), Positives = 106/244 (42%), Gaps = 15/244 (6%)
Query: 165 GNFAGGYIVKTLGMKMMFIITSLVSLIGILFLL-KIKERGRAKAGGDRLIIVKEGRESDR 223
G GG + G F ITS V +L +L +KE+ A+ R +
Sbjct: 4 GPLLGGMLADRFGFTYTFFITSFVIFSSVLLVLFGVKEKHLAEKTAKRTSYSR------- 56
Query: 224 VELKEIAFKKLMKGRLGIFYVAVLLAMIASGAVYATVSVYFEEKFGEEFVGYLFGIDSLS 283
KE+ L + + +L + ++ +++Y E G + + G+ +
Sbjct: 57 ---KEVLSYIFHHPALWVMMLLTMLIQTGNFSIQPLLALYVNELHGPVNLAFFSGMAFSA 113
Query: 284 AALSALIIGRLIDKYGEKLFFRLSLVGYIIT----FMGYALANSVIIMALISILSGLKWT 339
L +L++ R G++ R L+G ++ F+ ALA+S+ ++ + L G+
Sbjct: 114 TGLGSLLLARKWGDLGDRYGHRRILIGLLLAASFFFIPQALASSLSVLLVFRFLFGMAMG 173
Query: 340 MLTNSSSTYVARRVPTSERGQGMGLLNTMMTLGWVIGPLIGGILADNFGFAVMLYSTVPI 399
L + + + P S +G+ +G + LG V+GPL+GGI++ +F + Y T +
Sbjct: 174 GLLPCITAAIRVQAPGSIQGEVLGYNVSFRFLGNVLGPLLGGIISSHFTISATFYVTAFL 233
Query: 400 LFLG 403
F G
Sbjct: 234 FFAG 237
>pir||F72774 hypothetical protein APE0184 - Aeropyrum pernix (strain K1)
>gi|5103575|dbj|BAA79096.1| (AP000058) 412aa long
hypothetical protein [Aeropyrum pernix]
Length = 412
Score = 71.8 bits (173), Expect = 1e-11
Identities = 95/381 (24%), Positives = 165/381 (42%), Gaps = 29/381 (7%)
Query: 41 AWGLGFPYLGVYMKLIGGTMFLVGLLSVVYNLTSTIFQYPFGYLSDKTGKRKPFIILGIL 100
++G+ L YM G + GLL+ +TS IF G LSD G R+ + G +
Sbjct: 15 SFGVIVTVLAPYMYSAGFSGTEWGLLTSTATVTSIIFTLLSGPLSDALGARR-VVAAGYI 73
Query: 101 ASGTTYGLVALITSPILLLGLRAFQGALGASLAPAHSALISELSPRIGSMFGFFGFVENL 160
++ L+A+ ++ + G ++G S + A +AL++ S R + F F
Sbjct: 74 VKAASFTLLAVPSTVFMAAGFTLSGVSMGISWS-ATTALVAR-SGRDEMLHRSFTF---- 127
Query: 161 GFMAGNFAGGYIVKTLGM--KMMFIITSLVSL------IGILFLLKIKERGRAKAGGDRL 212
FMA N GG + +G+ ++ ITSL L I ++ L + + G A A +
Sbjct: 128 -FMASNMVGGALGSLMGVIPPLLSSITSLTLLEAYRATILLVAPLSLLQAGIALAVREE- 185
Query: 213 IIVKEGRESDRVELKEIAFKKLMKGRLGIFYVAVLLAMI----ASGAVYATVSVYFEEKF 268
+ EGR S F++ + R F + +L M+ AS +++ ++ YF K+
Sbjct: 186 -VSAEGRASIGPGELLRGFREAVSDRR--FRLLILFNMVIGLGASMSIH-NIAYYFAAKY 241
Query: 269 G--EEFVGYLFGIDSLSAALSALIIGRLIDKYGEKLFFRLSLVGYIITFM-GYALANSVI 325
G +G + ++ +S AL A+ R+ ++ G L ++L + + L +S +
Sbjct: 242 GVTSAEIGVVNALEQVSMALVAVGASRIAERVGSTLKVYIALTSLSVPLLVAMTLVDSYV 301
Query: 326 IMALISILSGLKWTMLTNSSSTYVARRVPTSERGQGMGLLNTMMTLGWVIGPLIGGILAD 385
+ A I ++ + R VP RG +L+ TL G IGG L D
Sbjct: 302 VAAAIYVVRTVLMNAANPLLEALTMRVVPRERRGSASSILSLSFTLPATAGRAIGGALLD 361
Query: 386 -NFGFAVMLYSTVPILFLGFL 405
N + L + + L L L
Sbjct: 362 INLELPLRLTAAIYTLALAHL 382
>dbj|BAB13163.1| (AP001119) hypothetical protein [Buchnera sp. APS]
Length = 390
Score = 71.8 bits (173), Expect = 1e-11
Identities = 96/392 (24%), Positives = 174/392 (43%), Gaps = 38/392 (9%)
Query: 29 LMFAIGMFFADFAWGLGFPYLGVY-MKLIGGTMFLVGLLSVVYNLTSTIFQYPFGYLSDK 87
L+ +GMF P L Y M L GG FL+GL +Y ++ IFQ PFG LSDK
Sbjct: 17 LLRMLGMFMI-------LPILSKYGMLLDGGNKFLIGLSMGIYGISQVIFQIPFGILSDK 69
Query: 88 TGKRKPFIILGILASGTTYGLVALITSPILLLGLRAFQGALGASLAPAHSALISEL---S 144
RK I+LG+ + A I S L+ R FQG+ +++ A +S+L
Sbjct: 70 F-NRKKIILLGLFMFFIGNIISASIHSIWGLIIGRFFQGS--GAISGVCMAFLSDLIREE 126
Query: 145 PRIGSMFGFFGFVENLGFMAGNFAGGYIVKTLGMKMMFIIT---SLVSLIGILFLLKIKE 201
R+ S+ G + F+ +G IV G +F I+ S+V +I + F + +
Sbjct: 127 NRVKSI-AAIGVSFAISFLIAVVSGPIIVHYFGFFSIFWISAFLSIVCMIIVCFFVPFSK 185
Query: 202 RGRAKAGGDRLIIVKEGR--ESDRVELKEIAFKKLMKGRLGIFYVAVLLAMIASGAV--Y 257
+ I+K+ + S + L + K + LG+F++ LL MI +
Sbjct: 186 KN----------ILKQNKTLHSYKKVLNFVLNKVFFRFYLGVFFLHFLL-MIKFTMIPNQ 234
Query: 258 ATVSVYFEEKFGEEFVGYLFGIDSLSAALSALIIGRLIDKYGEKLFFRLSLVGYIITFMG 317
+S + + + ++G + +S + L I KY + + ++ + + +
Sbjct: 235 FEISGFSLDNHWKVYLGTIL----ISFFVLFLFIFYCKYKYILENIIEICILFILFSEII 290
Query: 318 YALANSVIIMALISI-LSGLKWTMLTNSSSTYVARRVPTSERGQGMGLLNTMMTLGWVIG 376
+ A ++ +IS+ + + + L S++++R++ + RG M + +T LG G
Sbjct: 291 FLSAQKNLLFLIISLQIFFISFNFLEVFLSSHLSRQLSNNYRGSIMSIYSTSQFLGIFFG 350
Query: 377 PLIGGILADNFGFAVMLYSTVPILFLGFLLSF 408
+ G L F+ + Y + I+ L + SF
Sbjct: 351 GVFSGWLYSFLNFSQIFYFELFIILLWLIFSF 382
>pir||B72579 probable drug resistance protein APE1914 - Aeropyrum pernix
(strain K1) >gi|5105606|dbj|BAA80919.1| (AP000062) 372aa
long hypothetical drug resistance protein [Aeropyrum
pernix]
Length = 372
Score = 69.9 bits (168), Expect = 5e-11
Identities = 87/360 (24%), Positives = 147/360 (40%), Gaps = 31/360 (8%)
Query: 39 DFAWGLGFPYLGVYMKLIGGTMFLVGLLSVVYNLTSTIFQYPFGYLSDKTGKRKPFIILG 98
D A+ LG + Y + +G + G ++ +Y++ + G + DK G++K +I G
Sbjct: 2 DTAFLLGV--VAAYAEHLGASKAEAGFIAGLYSMAAIPASIAAGIVVDKVGRKKA-LIAG 58
Query: 99 ILASGTTYGLVALITSPILLLGLRAFQGALGASLAPAHSALISELSPRIGSMF--GFFGF 156
+ L ++P L R G+ + PA +++ + S R G + G +
Sbjct: 59 LAWDTLAVTLYTTASTPGELALYRGLHAIGGSLVYPAFFSIVGDTSRRGGEGYAAGRYLA 118
Query: 157 VENLGFMAGNFAGGYIVKTLGMKMMFIITSLVSLIGIL--FLLKIKERGRAKAGGDRLII 214
V G G+ AGG V+ LG + + SL+ IG L ++ G A+ G
Sbjct: 119 VIGAGVALGSAAGGRAVEMLGFQNALRLLSLILAIGTAAAVALPYRDSGIARRAG----- 173
Query: 215 VKEGRESDRVELKEIA--FKKLMKGRLGIFYVAVLLAMIASGAVYATVSVYFEEKFGEEF 272
V G + R+++ A L G GI + A+ G V E+
Sbjct: 174 VARGLMASRLKVLGAAATMASLYLG-FGILVGGLSTALTGEGVVEG-------EEEASAL 225
Query: 273 VGYLFGIDSLSAALSALIIGRLIDKYGEKLFFRLSLVGYIITFMGYALANS----VIIMA 328
G G+ S+++ + L+ GRLID L + + A + S ++ A
Sbjct: 226 AGLSIGVASIASLPAFLLSGRLIDAGRGALALAAASASALAGAAALAQSPSHPGVLVFAA 285
Query: 329 LISILSGLKWTMLTNSSSTYVARRVPTSERGQGMGLLNTMMTLGWVIGPLIGGILADNFG 388
L L G T+ STY+A VP RG + + LG +G +GG+L+ G
Sbjct: 286 LYGPLIGAGMTL-----STYLAITVPPWSRGTSIAIQQVSNILGVAVGAPLGGVLSGAMG 340
>gb|AAG20506.1| (AE005122) Vng2419c [Halobacterium sp. NRC-1]
Length = 387
Score = 69.1 bits (166), Expect = 9e-11
Identities = 74/314 (23%), Positives = 129/314 (40%), Gaps = 23/314 (7%)
Query: 81 FGYLSDKTGKRKPFIILGILASGTTYGLVALITSPILLLGLRAFQGALGASLAPAHS--- 137
+G SD+ G+R PFI G A Y ++A+ +P+ L G A + A GA+ A S
Sbjct: 61 WGAASDRAGRRTPFIAAGAAAGSLGYAVLAV--APLGLGGALALRVAQGAATIGAFSLAM 118
Query: 138 ALISELSPRIGSMFGFFGFVENLGFMAGNFAGGYIVKTLGMKMMFIITSLVSLIGILFLL 197
++ +LS G+ G G LG G GG + + L + ++ S+ + +
Sbjct: 119 TMLMDLSADHGADMGAAGIAIGLGTALGAPIGGQLTE-LAPRAPLVVGSVALAVAAAVTV 177
Query: 198 KIKERGRAKAGGDRLIIVKEGRESDRVELKEIAFKKLMKGRLGIFYVAVLLAMIASGAVY 257
++ + V R++ V L AF + + G F A++ +
Sbjct: 178 RLPDNAPTTTQSRLSAAVLAVRDTPAV-LVPYAFGFIDRFTAGFF------ALVGT---- 226
Query: 258 ATVSVYFEEKFGEEF--VGYLFGIDSLSAALSALIIGRLIDKYGEKLFFRLSLVGYIITF 315
+YF+ +FG + G + AL GRL D+ G + Y +
Sbjct: 227 ----LYFQSRFGLDAGATGLTLALFFAPFALLQYPFGRLSDRIGRTIPIAAGSALYGVAV 282
Query: 316 MGYALANSVIIMALISILSGLKWTMLTNSSSTYVARRVPTSERGQGMGLLNTMMTLGWVI 375
G +A + + + G+ ++ ++ V P +ERG M N +LG++
Sbjct: 283 AGVGVAPGLRVAQAGMVTVGVLGALMAPATMALVTDIAPDTERGVHMAGFNIAGSLGFLA 342
Query: 376 GPLIGGILADNFGF 389
G + GG +AD GF
Sbjct: 343 GIVGGGWIADRRGF 356
Database: ./suso.pep
Posted date: Jul 6, 2001 5:57 PM
Number of letters in database: 840,471
Number of sequences in database: 2977
Database: /banques/blast2/nr.pep
Posted date: Dec 14, 2000 12:46 PM
Number of letters in database: 188,266,275
Number of sequences in database: 595,510
Lambda K H
0.329 0.147 0.421
Gapped
Lambda K H
0.270 0.0470 0.230
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 140109077
Number of Sequences: 2977
Number of extensions: 5870093
Number of successful extensions: 26580
Number of sequences better than 1.0e-10: 65
Number of HSP's better than 0.0 without gapping: 3
Number of HSP's successfully gapped in prelim test: 62
Number of HSP's that attempted gapping in prelim test: 26330
Number of HSP's gapped (non-prelim): 123
length of query: 410
length of database: 189,106,746
effective HSP length: 54
effective length of query: 356
effective length of database: 156,788,448
effective search space: 55816687488
effective search space used: 55816687488
T: 11
A: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 40 (21.7 bits)
S2: 166 (69.1 bits)