BLASTP 2.0.10 [Aug-26-1999] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= PAB0961 (PAB0961) DE:dehydrogenase (392 letters) Database: ./suso.pep; /banques/blast2/nr.pep 598,487 sequences; 189,106,746 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value pir||G75056 dehydrogenase PAB0961 - Pyrococcus abyssi (strain Or... 771 0.0 pir||D71175 hypothetical protein PH0600 - Pyrococcus horikoshii ... 733 0.0 pir||C69276 coenzyme F420--quinone oxidoreductase (EC 1.6.5.-) 4... 189 5e-47 gi|11497827 conserved hypothetical protein [Archaeoglobus fulgid... 189 5e-47 gb|AAG19915.1| (AE005075) Vng1663c [Halobacterium sp. NRC-1] 171 9e-42 sp|Q58799|YE04_METJA HYPOTHETICAL PROTEIN MJ1404 >gi|2128840|pir... 131 1e-29 emb|CAC11941.1| (AL445065) conserved hypothetical protein [Therm... 91 2e-17 sp|Q59011|IMDH_METJA INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (IMP... 90 5e-17 gb|AAK42850.1| Conserved hypothetical protein [Sulfolobus solfat... 88 2e-16 sp|O58045|IMDH_PYRHO INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (IMP... 86 8e-16 sp|P42851|IMDH_PYRFU INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (IMP... 84 2e-15 gb|AAK40395.1| Conserved hypothetical protein [Sulfolobus solfat... 83 5e-15 pir||D69030 MJ1225-related protein MTH1223 - Methanobacterium th... 82 1e-14 pir||E75015 IMP dehydrogenase (EC 1.1.1.205) PAB1250 - Pyrococcu... 80 3e-14 pir||F72780 hypothetical protein APE0231 - Aeropyrum pernix (str... 80 6e-14 sp|Q58332|Y922_METJA HYPOTHETICAL PROTEIN MJ0922 >gi|2127741|pir... 79 1e-13 sp|Q58629|YC32_METJA HYPOTHETICAL PROTEIN MJ1232 >gi|2128738|pir... 78 2e-13 pir||D69035 MJ1232 protein homolog MTH126 - Methanobacterium the... 78 2e-13 pir||C69030 MJ1225 protein homolog MTH1222 - Methanobacterium th... 78 2e-13 sp|P15889|YR33_THEPE HYPOTHETICAL 33.4 KD PROTEIN IN RIBOSOMAL R... 76 5e-13 pir||F69185 yhcV homolog MTH644 - Methanobacterium thermoautotro... 76 6e-13 sp|P50100|IMDH_METKA PUTATIVE INOSINE-5'-MONOPHOSPHATE DEHYDROGE... 75 1e-12 gi|11498454 conserved hypothetical protein [Archaeoglobus fulgid... 75 1e-12 sp|Q58622|YC25_METJA HYPOTHETICAL PROTEIN MJ1225 >gi|2128050|pir... 75 2e-12 pir||C72264 IMP dehydrogenase (EC 1.1.1.205) - Thermotoga mariti... 74 3e-12 pir||C75148 hypothetical protein PAB2118 - Pyrococcus abyssi (st... 73 6e-12 gb|AAK43302.1| Conserved hypothetical protein [Sulfolobus solfat... 73 7e-12 pir||H72780 hypothetical protein APE0233 - Aeropyrum pernix (str... 73 7e-12 sp|O67820|IMDH_AQUAE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (IMP... 72 1e-11 pir||C71188 conserved hypothetical protein MJ1225 homolog - Pyro... 71 2e-11 pir||B72265 hypothetical protein TM1354 - Thermotoga maritima (s... 71 2e-11 >pir||G75056 dehydrogenase PAB0961 - Pyrococcus abyssi (strain Orsay) >gi|5458861|emb|CAB50348.1| (AJ248287) dehydrogenase [Pyrococcus abyssi] Length = 392 Score = 771 bits (1968), Expect = 0.0 Identities = 392/392 (100%), Positives = 392/392 (100%) Query: 1 MVGIQVQEVMTDRYAKIDINAPLSEAIGIIEKEDPDLILVFDDNVYKGVLTQDLIIRSHL 60 MVGIQVQEVMTDRYAKIDINAPLSEAIGIIEKEDPDLILVFDDNVYKGVLTQDLIIRSHL Sbjct: 1 MVGIQVQEVMTDRYAKIDINAPLSEAIGIIEKEDPDLILVFDDNVYKGVLTQDLIIRSHL 60 Query: 61 KWDPTKAKVRDVYKPAPVVKPTDDLSHAAKLLLETDLRSLPVGENKAEILGVISDMALLE 120 KWDPTKAKVRDVYKPAPVVKPTDDLSHAAKLLLETDLRSLPVGENKAEILGVISDMALLE Sbjct: 61 KWDPTKAKVRDVYKPAPVVKPTDDLSHAAKLLLETDLRSLPVGENKAEILGVISDMALLE 120 Query: 121 RVVAEEFGKRKVEEFMTKDVITLGPDDTVAKALATMRDHGISRIPVVDEEGKLEGLVTLH 180 RVVAEEFGKRKVEEFMTKDVITLGPDDTVAKALATMRDHGISRIPVVDEEGKLEGLVTLH Sbjct: 121 RVVAEEFGKRKVEEFMTKDVITLGPDDTVAKALATMRDHGISRIPVVDEEGKLEGLVTLH 180 Query: 181 DLIIRFIKPRFKAQYGELAGEKIPPFSMKLREAMIKGVITIMPEATIREAVSTMKDNNID 240 DLIIRFIKPRFKAQYGELAGEKIPPFSMKLREAMIKGVITIMPEATIREAVSTMKDNNID Sbjct: 181 DLIIRFIKPRFKAQYGELAGEKIPPFSMKLREAMIKGVITIMPEATIREAVSTMKDNNID 240 Query: 241 GLVVVDENNKVVGILTVKDLLLPISRMVEKEARFYLQLGGDASALSEFTRERIINDIKRF 300 GLVVVDENNKVVGILTVKDLLLPISRMVEKEARFYLQLGGDASALSEFTRERIINDIKRF Sbjct: 241 GLVVVDENNKVVGILTVKDLLLPISRMVEKEARFYLQLGGDASALSEFTRERIINDIKRF 300 Query: 301 VDGYADLLGNEGIIYLYIRRFNEKFRGVHLYQARMRVVTDRGVFIARGETWGAIQAVHDA 360 VDGYADLLGNEGIIYLYIRRFNEKFRGVHLYQARMRVVTDRGVFIARGETWGAIQAVHDA Sbjct: 301 VDGYADLLGNEGIIYLYIRRFNEKFRGVHLYQARMRVVTDRGVFIARGETWGAIQAVHDA 360 Query: 361 IRAIERQLLQKAELERDIRYAKRFIEKLELWR 392 IRAIERQLLQKAELERDIRYAKRFIEKLELWR Sbjct: 361 IRAIERQLLQKAELERDIRYAKRFIEKLELWR 392 >pir||D71175 hypothetical protein PH0600 - Pyrococcus horikoshii >gi|3257006|dbj|BAA29689.1| (AP000002) 392aa long hypothetical protein [Pyrococcus horikoshii] Length = 392 Score = 733 bits (1873), Expect = 0.0 Identities = 366/392 (93%), Positives = 386/392 (98%) Query: 1 MVGIQVQEVMTDRYAKIDINAPLSEAIGIIEKEDPDLILVFDDNVYKGVLTQDLIIRSHL 60 MVGIQVQEVMTD+YAKIDI+APLSEAIGIIEKEDPDLILVFDDNVYKGVLTQDLIIRSHL Sbjct: 1 MVGIQVQEVMTDKYAKIDISAPLSEAIGIIEKEDPDLILVFDDNVYKGVLTQDLIIRSHL 60 Query: 61 KWDPTKAKVRDVYKPAPVVKPTDDLSHAAKLLLETDLRSLPVGENKAEILGVISDMALLE 120 KWDPTKAKVRD+YKPAPVVKPTDDLSHAAKLLLETDLRSLPVGENKAEI+GVISD+ALLE Sbjct: 61 KWDPTKAKVRDIYKPAPVVKPTDDLSHAAKLLLETDLRSLPVGENKAEIIGVISDIALLE 120 Query: 121 RVVAEEFGKRKVEEFMTKDVITLGPDDTVAKALATMRDHGISRIPVVDEEGKLEGLVTLH 180 RVVAEEFGK+KVEEFMTKDVITL PDDTVAKALA MRDHGISRIP+V+EEGKLEGLVTLH Sbjct: 121 RVVAEEFGKKKVEEFMTKDVITLTPDDTVAKALAVMRDHGISRIPIVNEEGKLEGLVTLH 180 Query: 181 DLIIRFIKPRFKAQYGELAGEKIPPFSMKLREAMIKGVITIMPEATIREAVSTMKDNNID 240 DLI+RFIKPRFKAQ GEL GEKIPPFSMKLREAMI+GVITI+P AT+REAV+TMKDN+ID Sbjct: 181 DLILRFIKPRFKAQTGELVGEKIPPFSMKLREAMIRGVITILPTATVREAVATMKDNDID 240 Query: 241 GLVVVDENNKVVGILTVKDLLLPISRMVEKEARFYLQLGGDASALSEFTRERIINDIKRF 300 GLVVVDE NKVVGILTVKDLLLPISRMVEKEA+FYLQLGGDASALS+FTRERIINDIK+F Sbjct: 241 GLVVVDEGNKVVGILTVKDLLLPISRMVEKEAKFYLQLGGDASALSDFTRERIINDIKKF 300 Query: 301 VDGYADLLGNEGIIYLYIRRFNEKFRGVHLYQARMRVVTDRGVFIARGETWGAIQAVHDA 360 VDGY+DLLGNEGIIYLYIRRFNEKFRGVHLYQARMR+VTD+GVFIARGETWGAIQAVHDA Sbjct: 301 VDGYSDLLGNEGIIYLYIRRFNEKFRGVHLYQARMRIVTDKGVFIARGETWGAIQAVHDA 360 Query: 361 IRAIERQLLQKAELERDIRYAKRFIEKLELWR 392 IRAIERQLLQKAELERDIRYAKRFIEKLELWR Sbjct: 361 IRAIERQLLQKAELERDIRYAKRFIEKLELWR 392 >pir||C69276 coenzyme F420--quinone oxidoreductase (EC 1.6.5.-) 41K chain [validated] - Archaeoglobus fulgidus Length = 390 Score = 189 bits (475), Expect = 5e-47 Identities = 122/391 (31%), Positives = 216/391 (55%), Gaps = 17/391 (4%) Query: 6 VQEVMTDRYAKIDINAPLSEAIGIIEKEDPD---LILVFDDNVYKGVLTQDLIIRSHLKW 62 ++E++ D + I+ N +S+ ++EK D D ILV +D GV+ + +IR + Sbjct: 6 LKELIRDDFEVINANETVSKLFPMLEKLDRDKANAILVEEDGKIVGVVREKDLIRGSVLK 65 Query: 63 DPTKAKVRDVYKPAPVVKPTD-DLSHAAKLLLE--TDLRSLPVGENKAEILGVISDMALL 119 +P + KV+ + + + D A+ +E T + + + + ++ + ++ L Sbjct: 66 NPHETKVKSLLVRTGKIDLNELDPYKVARRFVEDSTPFVIVQIDDKRVGVIYINDFLSAL 125 Query: 120 ERVVAEEFGKRKVEEFMTKDVITLGPDDTVAKALATMRDHGISRIPVVDEEGKLEGLVTL 179 + +EF KV E M +VIT+ D+ AKAL+ MR HGI R+ VVDE K+ G++T Sbjct: 126 K----DEFKDVKVREVMNPEVITVRRFDSAAKALSVMRTHGIDRVVVVDENNKVIGILTG 181 Query: 180 HDLIIRFIKPRFKAQYGELAGEKIPPFSMKLREAMIKGVITIMPEATIREAVSTMKDNNI 239 D++ R I PR +A+ G+ +GEK S+ + M V+++ ++ E + M +N I Sbjct: 182 KDVVDRVISPRKRARMGDSSGEKEKTLSIMVESIMSSPVVSVSRNDSVAEVIDLMVENRI 241 Query: 240 DGLVVVDENNKVVGILTVKDLLLPISRMVEKEAR--FYLQLGGDASALSEFTRERIINDI 297 VVV + GI+ KD+L ++KE+R F +Q+ L EF RE I+ D+ Sbjct: 242 SS-VVVTRDGLPDGIVIKKDIL---EYYLKKESRKEFNVQISTADITLDEFDREAILEDV 297 Query: 298 KRFVDGYADLLGNEGIIYLYIRRFNEKFRGVHLYQARMRVVTDRGVFIARGETWGAIQAV 357 ++ + ++D LG E +++YI+R E FR + L R+++ +++G F+ GE+WG AV Sbjct: 298 EKLMRKFSDFLG-ESFLFIYIKRHKEHFRNLPLIHVRLKLASEKGNFMVSGESWGVEYAV 356 Query: 358 HDAIRAIERQLLQKAELERDIRYAKRFIEKL 388 H A++ +ER++L++ EL D R KRF E++ Sbjct: 357 HVALKKLEREILKEKELLEDKRMIKRFYEEV 387 >gi|11497827 conserved hypothetical protein [Archaeoglobus fulgidus] >gi|2650431|gb|AAB91022.1| (AE001091) conserved hypothetical protein [Archaeoglobus fulgidus] Length = 393 Score = 189 bits (475), Expect = 5e-47 Identities = 122/391 (31%), Positives = 216/391 (55%), Gaps = 17/391 (4%) Query: 6 VQEVMTDRYAKIDINAPLSEAIGIIEKEDPD---LILVFDDNVYKGVLTQDLIIRSHLKW 62 ++E++ D + I+ N +S+ ++EK D D ILV +D GV+ + +IR + Sbjct: 9 LKELIRDDFEVINANETVSKLFPMLEKLDRDKANAILVEEDGKIVGVVREKDLIRGSVLK 68 Query: 63 DPTKAKVRDVYKPAPVVKPTD-DLSHAAKLLLE--TDLRSLPVGENKAEILGVISDMALL 119 +P + KV+ + + + D A+ +E T + + + + ++ + ++ L Sbjct: 69 NPHETKVKSLLVRTGKIDLNELDPYKVARRFVEDSTPFVIVQIDDKRVGVIYINDFLSAL 128 Query: 120 ERVVAEEFGKRKVEEFMTKDVITLGPDDTVAKALATMRDHGISRIPVVDEEGKLEGLVTL 179 + +EF KV E M +VIT+ D+ AKAL+ MR HGI R+ VVDE K+ G++T Sbjct: 129 K----DEFKDVKVREVMNPEVITVRRFDSAAKALSVMRTHGIDRVVVVDENNKVIGILTG 184 Query: 180 HDLIIRFIKPRFKAQYGELAGEKIPPFSMKLREAMIKGVITIMPEATIREAVSTMKDNNI 239 D++ R I PR +A+ G+ +GEK S+ + M V+++ ++ E + M +N I Sbjct: 185 KDVVDRVISPRKRARMGDSSGEKEKTLSIMVESIMSSPVVSVSRNDSVAEVIDLMVENRI 244 Query: 240 DGLVVVDENNKVVGILTVKDLLLPISRMVEKEAR--FYLQLGGDASALSEFTRERIINDI 297 VVV + GI+ KD+L ++KE+R F +Q+ L EF RE I+ D+ Sbjct: 245 SS-VVVTRDGLPDGIVIKKDIL---EYYLKKESRKEFNVQISTADITLDEFDREAILEDV 300 Query: 298 KRFVDGYADLLGNEGIIYLYIRRFNEKFRGVHLYQARMRVVTDRGVFIARGETWGAIQAV 357 ++ + ++D LG E +++YI+R E FR + L R+++ +++G F+ GE+WG AV Sbjct: 301 EKLMRKFSDFLG-ESFLFIYIKRHKEHFRNLPLIHVRLKLASEKGNFMVSGESWGVEYAV 359 Query: 358 HDAIRAIERQLLQKAELERDIRYAKRFIEKL 388 H A++ +ER++L++ EL D R KRF E++ Sbjct: 360 HVALKKLEREILKEKELLEDKRMIKRFYEEV 390 >gb|AAG19915.1| (AE005075) Vng1663c [Halobacterium sp. NRC-1] Length = 380 Score = 171 bits (430), Expect = 9e-42 Identities = 108/387 (27%), Positives = 203/387 (51%), Gaps = 12/387 (3%) Query: 4 IQVQEVMTDRYAKIDINAPLSEAIGIIEKEDPDLILVFDDNVYKGVLTQDLIIRSHLKWD 63 + + ++ + Y ++D L + + E+E+P ++V + Y GV+T+ +I+SH+ D Sbjct: 1 MDISDIAANDYVEVDAEQRLGKVRSLFERENPKGVIVTEAGAYDGVITERQLIQSHIGDD 60 Query: 64 PTKAKVRDVYKPAPVVKPTDDLSHAAKLLLETDLRSLPVGENKAEILGVISDMALLERVV 123 +V + AP V T+D+ A++L+E + PV E + GVI++ A+L+ V+ Sbjct: 61 ---TRVAAMVTDAPKVSRTEDVRETARMLVEGGTKIAPVFE-AGSLWGVITEDAILDAVL 116 Query: 124 AEEFGKRKVEEFMTKDVITLGPDDTVAKALATMRDHGISRIPVVDEEGKLEGLVTLHDLI 183 A V + T+ V+T+ DD++ + + +R+HGISR+PVVD+ G L G+VT +D++ Sbjct: 117 AN-LDALDVRDIYTEHVVTVDEDDSMGRVINLLREHGISRLPVVDDAGLLSGIVTRYDIV 175 Query: 184 IRFIKPRFKAQYGELAGEKIPPFSMKLREAMIKGVITIMPEATIREAVSTMKDNNIDGLV 243 ++ K G+ +GE + + + M V T + ++R+AV M ++ G++ Sbjct: 176 DFVVRDTEKTTVGDRSGEIERLLDLPVSDEMTSPVKTASFDDSVRDAVDDMLAHDYSGVI 235 Query: 244 VV--DENNKVVGILTVKDLLLPISRMVEKEARFYLQLGGDASALSEFTRERIINDIKRFV 301 V D+ V GILT D+L +S E+ + + L +R+ + I+ V Sbjct: 236 VTPDDDERAVGGILTKTDVLRALSYTEEEHLDVQIT---NIDLLDTLSRQEVRERIENVV 292 Query: 302 DGYADLLGNEGIIYLYIRRFNEKFRGVHLYQARMRVVTDRGVFIARGETWGAIQAVHDAI 361 Y D+ + ++ + + EK RG L Q+++R+ T++G GE +GA + H A+ Sbjct: 293 AKYGDMDVHHA--HVRLSKHKEKLRGTPLIQSQIRLRTNKGQIAGTGEGYGADNSFHVAL 350 Query: 362 RAIERQLLQKAELERDIRYAKRFIEKL 388 +ER +L+ +E D Y + + KL Sbjct: 351 DKLERNVLELKGIEHDEEYEGQLLRKL 377 >sp|Q58799|YE04_METJA HYPOTHETICAL PROTEIN MJ1404 >gi|2128840|pir||C64475 hypothetical protein MJ1404 - Methanococcus jannaschii >gi|1592053|gb|AAB99421.1| (U67581) M. jannaschii predicted coding region MJ1404 [Methanococcus jannaschii] Length = 421 Score = 131 bits (326), Expect = 1e-29 Identities = 108/397 (27%), Positives = 193/397 (48%), Gaps = 41/397 (10%) Query: 1 MVGIQVQEVMTDRYAKIDINAPLSEAIGIIEKEDPDLILVFDDN----VYKGVLTQDLII 56 M+ V+E+MT + + P+S+A+GI+E+ ++V D Y + +DL++ Sbjct: 4 MLNEPVKEIMTKDVVTVTPDTPVSKALGIMEENGFHHLIVVDKKDGKEEYYLISMRDLLL 63 Query: 57 RSHLKWDPTKAKVRDVYKPAPVVKPTDDLSHAAKLLLETDLRSLPVGENKAEILGVISDM 116 S T +VR + A V A +L++ R+ P+ N +++G+I+D Sbjct: 64 ASS-----TDEEVRSLMYKAHCVHEDTPFLDAVCEMLDSGQRAAPIVNNVGKMVGIITDY 118 Query: 117 ALLERVVAEEFGK-RKVEEFMTKDVITLGPDDTVAKALATMRDHGISRIPVVDEEGKLEG 175 ++ R + K KV + MT++VIT+ +D++ KA A MRD+ I R+ VVD+EG G Sbjct: 119 DIMARAAKSKIMKDTKVTKIMTRNVITINENDSIGKARALMRDNNIGRLVVVDDEGNPVG 178 Query: 176 LVTLHDLIIRFIKPRFKAQYGELAGEKIPPFSMKLREAMIKGVITIMPEATIREAVSTMK 235 +VT D++ + KP+ K GE GEK+P +R M +IT+ +A+ +A M+ Sbjct: 179 MVTEVDILKKVFKPKKKMTAGEFKGEKVPRMGQPVRLIMNTPLITVDVDASAADAARVMQ 238 Query: 236 DNNIDGLVVVDENNKVVGILTVKDLLLPISRMVEKEARFYLQLGGDASALSEFTRERII- 294 + +I G+ VV + + GI+T D++ I+ + +K A ++L G + ERII Sbjct: 239 EYDIRGVPVV-KGKSLRGIVTRLDIIKYIADL-KKGAMIEIELHGMLDPEFKDLAERIIA 296 Query: 295 NDIKRFVDGYADLLGNEGIIYLYIRRFNEKFRGVHLYQARMRVVTDRGVFIARG------ 348 ++K+ V G I + I++ +K GV Y+ V T +++ G Sbjct: 297 TEVKKMVKH----AGKIHWIKITIKKERDK-GGVPYYRITTYVKTPNKLYVGEGRPKASL 351 Query: 349 -----------------ETWGAIQAVHDAIRAIERQL 368 E W I + +++ ++ RQL Sbjct: 352 PNKLEAEGEDIAYVSEHERWEFIDVLKESLESVLRQL 388 >emb|CAC11941.1| (AL445065) conserved hypothetical protein [Thermoplasma acidophilum] Length = 362 Score = 90.9 bits (222), Expect = 2e-17 Identities = 82/373 (21%), Positives = 179/373 (47%), Gaps = 16/373 (4%) Query: 4 IQVQEVMTDRYAKIDINAPLSEAIGIIEKEDPDLILVFDDNVYKGVLT-QDLIIRSHLKW 62 ++V E+MT + I+ S+ + + + + V D + Y G++T DL+ + ++ Sbjct: 1 MKVSELMTTDPITVSIDDTFSKVMSKMNETGIHQLPVMDGDRYAGMITYSDLLKKRSIQ- 59 Query: 63 DPTKAKVRDVYKPAPVVKPTDDLSHAAKLLLETDLRSLPVGENKAEILGVISDMALLERV 122 K+K+ + P + DD+ A +L+ +T L +LPV + K +++G+IS +++ + Sbjct: 60 --VKSKISNYTISTPTLNADDDVLEAVRLIKDTGLSALPVFQ-KGKLVGIISRTDIIKNL 116 Query: 123 VA-EEFGKRKVEEFMTKDVITLGPDDTVAKALATMRDHGISRIPVVDEEGKLEGLVTLHD 181 + ++ + M+ D I + DD + +A +MR IPV + KL G++ L+ Sbjct: 117 PQIVDVRDVRIFQIMSSDPIYVYEDDDIEEAFDSMRMLNEVEIPVASRDEKLSGIIRLNS 176 Query: 182 LIIRFIKPRFKAQYGELAGEKIPPFSMKLREAMIKGVITIMPEATIREAVSTMKDNNIDG 241 ++ + + K +YG GEK P +K + +++ +++ A I EAV M ++ Sbjct: 177 ILNILYRQKEKIKYGGY-GEK-EPVEIKCK-SLMDPPVSVDRYAGIDEAVKLMMQYSLH- 232 Query: 242 LVVVDENNKVVGILTVKDLLLPISRMVEKEARFYLQLGGDASALSEFTRERIINDIKRFV 301 ++ V ++ K+VGI+ DL+ I E + +++ G E + +RF+ Sbjct: 233 IMPVTDSGKIVGIVDFSDLINMIK--TESKEGILIEISG-LDVYDEDLYDIAFELSERFL 289 Query: 302 DGYADLLG-NEGIIYLYIRRFNEKFRGVHLYQARMRVVTDRGVFIARGETWGAIQAVHDA 360 D ++ + ++G + +++ ++ K +G Y R R+ + G W + + + Sbjct: 290 DKFSKMTDVSQGKLLIHVMKY--KTQGSTKYSIRTRISAPPLFLVQNGSGWNFAEVLGEI 347 Query: 361 IRAIERQLLQKAE 373 E ++ + E Sbjct: 348 FDRYEERIKKMKE 360 >sp|Q59011|IMDH_METJA INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (IMP DEHYDROGENASE) (IMPDH) (IMPD) >gi|2117504|pir||G64501 IMP dehydrogenase (EC 1.1.1.205) - Methanococcus jannaschii >gi|1592337|gb|AAB99638.1| (U67602) inosine-5'-monophosphate dehydrogenase, (guaB) [Methanococcus jannaschii] Length = 496 Score = 89.7 bits (219), Expect = 5e-17 Identities = 51/152 (33%), Positives = 84/152 (54%), Gaps = 18/152 (11%) Query: 110 LGVISDMALLERVVAEEFGKRKVEEFMTKDVITLGPDDTVAKALATMRDHGISRIPVVDE 169 LGVI +E V + +K +E + KDVIT+ PDDTV +A+ M + IS +PVVD Sbjct: 70 LGVIHRNMSIEEQVHQVQAVKKADEVVIKDVITVSPDDTVGEAINVMETYSISGLPVVDN 129 Query: 170 EGKLEGLVTLHDLIIRFIKPRFKAQYGELAGEKIPPFSMKLREAMIKGVITIMPEATIRE 229 E KL G++T D ++ I+ + K K+++ M K V+ + E Sbjct: 130 EDKLVGIITHRD--VKAIEDKTK----------------KVKDVMTKDVVCAKEDVEEEE 171 Query: 230 AVSTMKDNNIDGLVVVDENNKVVGILTVKDLL 261 A+ M N ++ L +VD+ N+++GI+T++D+L Sbjct: 172 ALELMYANRVERLPIVDDENRLIGIITLRDIL 203 >gb|AAK42850.1| Conserved hypothetical protein [Sulfolobus solfataricus] Length = 250 Score = 88.2 bits (215), Expect = 2e-16 Identities = 62/242 (25%), Positives = 125/242 (51%), Gaps = 21/242 (8%) Query: 23 LSEAIGIIEKEDPDLILVFDDNVYKGVLTQDLIIRSHLKWDPT--KAKVRDVY-KPAPVV 79 L EAI I+ I+V + G+++ ++ S ++ KV+D+ K +V Sbjct: 20 LKEAIDILSNNPSGRIVVLKEEKPIGIVSTRDVVASFSEYGTNIYDLKVKDIMSKDLVIV 79 Query: 80 KPTDDLSHAAKLLLETDLRSLPVGENKAEILGVISDMALLERVVAEEFGKRKVEEFMTKD 139 P DD++H +++L ++ +PV +N I+G+ ++ +L+ + + F V+ M+ + Sbjct: 80 SPNDDVNHVVRIMLMNNIGGIPVVDNNV-IVGIFTEREILKLIASSMFSGL-VDSVMSSN 137 Query: 140 VITLGPDDTVAKALATMRDHGISRIPVVDEEGKLEGLVTLHDLIIRFIKPRFKAQYGELA 199 +I++G ++T+ A M + + R+PV ++ +L G++T D++ ++ A+ + Sbjct: 138 IISIGEENTIMDAAKLMVMNNVRRLPVFSKDNRLVGIITAADIV------KYLAKNKNIG 191 Query: 200 GEKIPPFSMKLREAMIKGVITIMPEATIREAVSTMKDNNIDGLVVVDENNKVVGILTVKD 259 K+ +A K ITI +I A M + I G ++V EN K+VGI+T +D Sbjct: 192 ---------KVLDAGTKNPITINRYYSILNAAKLMIEKRI-GTLLVMENQKLVGIVTERD 241 Query: 260 LL 261 L+ Sbjct: 242 LM 243 >sp|O58045|IMDH_PYRHO INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (IMP DEHYDROGENASE) (IMPDH) (IMPD) >gi|7427688|pir||E71456 IMP dehydrogenase (EC 1.1.1.205) - Pyrococcus horikoshii >gi|3256697|dbj|BAA29380.1| (AP000001) 486aa long hypothetical inosine-5'-monophosphate dehydrogenase [Pyrococcus horikoshii] Length = 486 Score = 85.8 bits (209), Expect = 8e-16 Identities = 68/196 (34%), Positives = 101/196 (50%), Gaps = 29/196 (14%) Query: 110 LGVISDMALLERVVAEEFGKRKVEEFMTKDVITLGPDDTVAKALATMRDHGISRIPVVDE 169 LGVI +E V + ++ E + +DVIT+ PD+TV AL M HGI +PVV++ Sbjct: 73 LGVIHRNMGIEEQVEQVKRVKRAERLIVEDVITIAPDETVDFALFLMEKHGIDGLPVVED 132 Query: 170 EGKLEGLVTLHDLIIRFIKPRFKAQYGELAGEKIPPFSMKLREAMIKGVITIMPEATIRE 229 E K+ G++T D+ A+ G+L ++E M K VIT+ + E Sbjct: 133 E-KVVGIITKKDIA---------AREGKL-----------VKELMTKEVITVPESIEVEE 171 Query: 230 AVSTMKDNNIDGLVVVDENNKVVGILTVKDLLLPISRMVEKEARFYLQLGGD---ASALS 286 A+ M +N ID L VVDE K+VG++T+ DL ++R K A G+ A+A+S Sbjct: 172 ALKIMIENRIDRLPVVDERGKLVGLITMSDL---VARKKYKNA--VRDENGELLVAAAVS 226 Query: 287 EFTRERIINDIKRFVD 302 F +R I K VD Sbjct: 227 PFDIKRAIELDKAGVD 242 Score = 72.6 bits (175), Expect = 7e-12 Identities = 73/264 (27%), Positives = 132/264 (49%), Gaps = 21/264 (7%) Query: 8 EVMTDRYAKIDINAP-LSEAIGIIEKEDPDLILVFDDNVYKGVLTQDLIIRSHLKW-DPT 65 +V T + +N P LS A+ + + + + + + + GV+ +++ I ++ Sbjct: 35 DVSTRITPNVKLNIPILSAAMDTVTEWEMAVAMAREGGL--GVIHRNMGIEEQVEQVKRV 92 Query: 66 KAKVRDVYKPAPVVKPTDDLSHAAKLLLETDLRSLPVGENKAEILGVISDMALLERVVAE 125 K R + + + P + + A L+ + + LPV E++ +++G+I+ ++ +A Sbjct: 93 KRAERLIVEDVITIAPDETVDFALFLMEKHGIDGLPVVEDE-KVVGIIT-----KKDIAA 146 Query: 126 EFGKRKVEEFMTKDVITLGPDDTVAKALATMRDHGISRIPVVDEEGKLEGLVTLHDLIIR 185 GK V+E MTK+VIT+ V +AL M ++ I R+PVVDE GKL GL+T+ DL+ R Sbjct: 147 REGKL-VKELMTKEVITVPESIEVEEALKIMIENRIDRLPVVDERGKLVGLITMSDLVAR 205 Query: 186 -FIKPRFKAQYGE-LAGEKIPPFSMK----LREAMIKGVITIMPEATIREAVSTMKD--N 237 K + + GE L + PF +K L +A + ++ A +A+ +MK+ Sbjct: 206 KKYKNAVRDENGELLVAAAVSPFDIKRAIELDKAGVDVIVVDTAHAHNLKAIKSMKEMRQ 265 Query: 238 NIDGLVVVDE--NNKVVGILTVKD 259 +D +V N K V LT D Sbjct: 266 KVDADFIVGNIANPKAVDDLTFAD 289 >sp|P42851|IMDH_PYRFU INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (IMP DEHYDROGENASE) (IMPDH) (IMPD) >gi|2117506|pir||JC4998 IMP dehydrogenase (EC 1.1.1.205) - Pyrococcus furiosus >gi|595287|gb|AAC44532.1| (U08814) IMP dehydrogenase [Pyrococcus furiosus] Length = 485 Score = 84.3 bits (205), Expect = 2e-15 Identities = 50/152 (32%), Positives = 81/152 (52%), Gaps = 21/152 (13%) Query: 110 LGVISDMALLERVVAEEFGKRKVEEFMTKDVITLGPDDTVAKALATMRDHGISRIPVVDE 169 LGVI +E V + ++ E F+ +DVIT+ PD+T+ AL M HGI +PVV+E Sbjct: 73 LGVIHRNMSIEEQVEQVKRVKRAERFIVEDVITIAPDETIDYALFLMEKHGIDGLPVVEE 132 Query: 170 EGKLEGLVTLHDLIIRFIKPRFKAQYGELAGEKIPPFSMKLREAMIKGVITIMPEATIRE 229 + ++ G++T D+ R ++E M + VIT+ + E Sbjct: 133 D-RVVGIITKKDIAARE--------------------GRTVKELMTREVITVPESVDVEE 171 Query: 230 AVSTMKDNNIDGLVVVDENNKVVGILTVKDLL 261 A+ M +N ID L VV+E+ K+VG++T+ DL+ Sbjct: 172 ALKIMMENRIDRLPVVNEDGKLVGLITMSDLV 203 Score = 71.0 bits (171), Expect = 2e-11 Identities = 70/264 (26%), Positives = 129/264 (48%), Gaps = 21/264 (7%) Query: 8 EVMTDRYAKIDINAP-LSEAIGIIEKEDPDLILVFDDNVYKGVLTQDLIIRSHLKW-DPT 65 +V T + +N P LS A+ + + + + + + + GV+ +++ I ++ Sbjct: 35 DVSTQITPNVKLNIPILSAAMDTVTEWEMAVAMAREGGL--GVIHRNMSIEEQVEQVKRV 92 Query: 66 KAKVRDVYKPAPVVKPTDDLSHAAKLLLETDLRSLPVGENKAEILGVISDMALLERVVAE 125 K R + + + P + + +A L+ + + LPV E ++G+I+ ++ +A Sbjct: 93 KRAERFIVEDVITIAPDETIDYALFLMEKHGIDGLPVVEED-RVVGIIT-----KKDIAA 146 Query: 126 EFGKRKVEEFMTKDVITLGPDDTVAKALATMRDHGISRIPVVDEEGKLEGLVTLHDLIIR 185 G R V+E MT++VIT+ V +AL M ++ I R+PVV+E+GKL GL+T+ DL+ R Sbjct: 147 REG-RTVKELMTREVITVPESVDVEEALKIMMENRIDRLPVVNEDGKLVGLITMSDLVAR 205 Query: 186 -FIKPRFKAQYGE-LAGEKIPPFSMK----LREAMIKGVITIMPEATIREAVSTMKDN-- 237 K + + GE L + PF ++ L A + ++ A +A+ MK+ Sbjct: 206 KKYKNAVRNEKGELLVAAAVSPFDLRRAIELDRAGVDVIVVDTAHAHNLKAIKAMKEMRQ 265 Query: 238 --NIDGLVVVDENNKVVGILTVKD 259 + D +V N K V LT D Sbjct: 266 KVSADFIVGNIANPKAVDDLTFAD 289 >gb|AAK40395.1| Conserved hypothetical protein [Sulfolobus solfataricus] Length = 380 Score = 83.1 bits (202), Expect = 5e-15 Identities = 79/356 (22%), Positives = 168/356 (47%), Gaps = 19/356 (5%) Query: 23 LSEAIGIIEKEDPDLILVFDDNVYKGVLT-QDLIIRSHLKWDPTKAKVRDVYKPAPVVKP 81 LS+ I +++ + V D G+++ +DL+ R + K ++ P+ V+ Sbjct: 20 LSDIISKMKENKMWTVPVIKDRKLIGLISYKDLLSRRV----SLETKAINIMSPSVTVQI 75 Query: 82 TDDLSHAAKLLLETDLRSLPVGENKAEILGVISDMALLERVV-AEEFGK-RKVEEFMTKD 139 +D++ T R +PV K E +G+++ +LL ++ A E + R E+MT Sbjct: 76 DEDINRLIAKFYTTKARVIPVINEKREFIGLVTRESLLSYLLKANEIPENRTAREYMTSP 135 Query: 140 VITLGPDDTVAKALATMRDHGISRIPVVDEEGKLEGLVTLHDLIIRFIKPRFKAQYGELA 199 ++ +D++A+A M ISR+P +E +L G+++ D++ + + + Sbjct: 136 ATSIDENDSIARARWLMIRDNISRLPAT-KEYRLTGIISARDIVDALYSVSGRKRESIMK 194 Query: 200 GEKIPPFSMKLREAMIKGVITIMPEATIREAVSTMKDNNIDGLVVVDENNKVVGILTVKD 259 E+ +M ++E M VIT + ++ + V + I G+ V+ E +++ G+++ D Sbjct: 195 DEE-RVMAMPVKEIMKYPVITANGKDSLTDVVEKLLKFRISGMPVM-EGDRLSGVISGLD 252 Query: 260 LLLPISRMVEKEARFYLQLGGDASALSEFTRERIINDIKRFVDGYADLLGNEGIIYLYIR 319 ++ ++ ++ ++ + + EF I+DI ++ Y + + + Sbjct: 253 IIKAVAEKMQLSIPIEAKIPQELKSNLEFKAN--IDDI---LERYLSKIERLTEVINFKV 307 Query: 320 RFNEKFR----GVHLYQARMRVVTDRGVFIARGETWGAIQAVHDAIRAIERQLLQK 371 F E+ R LY A +RV T G ++AR W + A+ +A+ IE ++L+K Sbjct: 308 SFKEEMRSSTGNKKLYTAMVRVTTKIGDYVARDTDWEPVVALKNAVEKIEERILRK 363 >pir||D69030 MJ1225-related protein MTH1223 - Methanobacterium thermoautotrophicum (strain Delta H) >gi|2622334|gb|AAB85712.1| (AE000890) inosine-5'-monophosphate dehydrogenase related protein II [Methanobacterium thermoautotrophicum] Length = 281 Score = 81.9 bits (199), Expect = 1e-14 Identities = 76/280 (27%), Positives = 132/280 (47%), Gaps = 22/280 (7%) Query: 1 MVGIQVQEVMTDRYAKIDINAPLSEAIGIIEKEDPDLILVFD-DNVYKGVLTQDLIIRSH 59 MV + + +MTD +D ++ A ++ + ++V D D G++T+ I R Sbjct: 1 MVTVDIGSIMTDEVIVMDETQQVAYARNLMLRHGISRVVVVDADGKPVGIVTETDITRKL 60 Query: 60 LKWDPT-------KAKVRDVYKPAPV-VKPTDDLSHAAKLLLETDLRSLPVGENKAEILG 111 P K +R V PV V D AA+L+L ++ SL V + + E+ G Sbjct: 61 RVNGPDWRRRPIDKISIRRVMTENPVTVNVNDTPRDAAELMLRKNVGSLLVMDGE-ELAG 119 Query: 112 VISDMALLERVVAEEFGKRKVEEFMTKDVITLGPDDTVAKALATMRDHGISRIPVVDEEG 171 +++ LL G+ KV + MT+DV T+ P+ T++ + M ++ ISR+ VV + G Sbjct: 120 IVTKKDLLRFFKDRCAGRWKVRDLMTEDVKTVTPNHTLSHVIGVMEENNISRV-VVTDNG 178 Query: 172 KLEGLVTLHDL-IIRFIKPR---------FKAQYGELAGEKIPPFSMKLREAMIKGVITI 221 +EG++T +L F P F ++ E + + M + VI + Sbjct: 179 AVEGIITSENLSFATFEDPERGIPVERVYFISRTSEEKKRVRTIAMLTAGDIMTEDVIKV 238 Query: 222 MPEATIREAVSTMKDNNIDGLVVVDENNKVVGILTVKDLL 261 P A + M +N I GL VV E++++VGI+T D++ Sbjct: 239 EPSVDASSAAAMMLENGISGLPVV-EDDELVGIITKTDII 277 >pir||E75015 IMP dehydrogenase (EC 1.1.1.205) PAB1250 - Pyrococcus abyssi (strain Orsay) >gi|5459077|emb|CAB50563.1| (AJ248288) INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (EC 1.1.1.205) (IMP DEHYDROGENASE) (IMPDH) (IMPD). [Pyrococcus abyssi] Length = 485 Score = 80.4 bits (195), Expect = 3e-14 Identities = 51/152 (33%), Positives = 82/152 (53%), Gaps = 21/152 (13%) Query: 110 LGVISDMALLERVVAEEFGKRKVEEFMTKDVITLGPDDTVAKALATMRDHGISRIPVVDE 169 LGVI +E V + +K E F+ +DVIT+ P++TV AL M H I +PVV+ Sbjct: 73 LGVIHRNMSIEEQVEQVKRVKKAERFIVEDVITISPEETVDFALFLMEKHDIDGLPVVEN 132 Query: 170 EGKLEGLVTLHDLIIRFIKPRFKAQYGELAGEKIPPFSMKLREAMIKGVITIMPEATIRE 229 E K+ G+++ D+ A+ G+L ++E M K VIT+ + E Sbjct: 133 E-KVVGIISKKDIA---------AREGKL-----------VKELMTKDVITVPENIEVEE 171 Query: 230 AVSTMKDNNIDGLVVVDENNKVVGILTVKDLL 261 A+ M +N ID L VVD+ +++G++T+ DL+ Sbjct: 172 ALKIMIENRIDRLPVVDKEGRLIGLITMSDLV 203 Score = 78.0 bits (189), Expect = 2e-13 Identities = 75/264 (28%), Positives = 133/264 (49%), Gaps = 21/264 (7%) Query: 8 EVMTDRYAKIDINAP-LSEAIGIIEKEDPDLILVFDDNVYKGVLTQDLIIRSHLKW-DPT 65 +V T + +N P LS A+ + + + + + + + GV+ +++ I ++ Sbjct: 35 DVSTQITPNVKLNIPILSAAMDTVTEWEMAVAMAREGGL--GVIHRNMSIEEQVEQVKRV 92 Query: 66 KAKVRDVYKPAPVVKPTDDLSHAAKLLLETDLRSLPVGENKAEILGVISDMALLERVVAE 125 K R + + + P + + A L+ + D+ LPV EN+ +++G+IS ++ +A Sbjct: 93 KKAERFIVEDVITISPEETVDFALFLMEKHDIDGLPVVENE-KVVGIIS-----KKDIAA 146 Query: 126 EFGKRKVEEFMTKDVITLGPDDTVAKALATMRDHGISRIPVVDEEGKLEGLVTLHDLIIR 185 GK V+E MTKDVIT+ + V +AL M ++ I R+PVVD+EG+L GL+T+ DL+ R Sbjct: 147 REGKL-VKELMTKDVITVPENIEVEEALKIMIENRIDRLPVVDKEGRLIGLITMSDLVAR 205 Query: 186 -FIKPRFKAQYGE-LAGEKIPPF----SMKLREAMIKGVITIMPEATIREAVSTMKD--N 237 K + + GE L + PF +++L A ++ A +A+ MK+ Sbjct: 206 KKYKNAVRDENGELLVAAAVSPFDIRRAIELDRAGADVIVVDTAHAHNLKAIKAMKEMRQ 265 Query: 238 NIDGLVVVDE--NNKVVGILTVKD 259 +D +V N K V LT D Sbjct: 266 KVDADFIVGNIANPKAVDDLTFAD 289 >pir||F72780 hypothetical protein APE0231 - Aeropyrum pernix (strain K1) >gi|5103623|dbj|BAA79144.1| (AP000058) 287aa long hypothetical protein [Aeropyrum pernix] Length = 287 Score = 79.6 bits (193), Expect = 6e-14 Identities = 53/161 (32%), Positives = 85/161 (51%), Gaps = 22/161 (13%) Query: 131 KVEEFMTKDVITLGPDDTVAKALATMRDHGISRIPVVDEEGKLEGLVTLHDLIIRFIKPR 190 +V +MT+DV T+ PDDT+A A M H ISR+PVV E KL G++T+ D+ ++ + Sbjct: 4 RVVSYMTRDVYTVSPDDTLAHARKLMLTHDISRLPVV-EGSKLRGIITITDIADALVR-K 61 Query: 191 FKAQYGELAGEKIPPFSMKLREAMIKGVITIMPEATIREAVSTMKDNNIDGLVVVDENNK 250 + ++ P S+ +RE M + V+TI +++ A S M +NI G+ VV + Sbjct: 62 YPSR---------PANSIYVREVMARDVVTIEGTKSVKTAASLMLKHNIGGVPVVAPDGT 112 Query: 251 VVGILTVKDLLLPISRMVEKEARFYLQLGGDASALSEFTRE 291 + GI+T DL R+Y + + + EF RE Sbjct: 113 LEGIITRTDL-----------TRYYSEKMKGVNLVKEFMRE 142 Score = 71.0 bits (171), Expect = 2e-11 Identities = 61/195 (31%), Positives = 95/195 (48%), Gaps = 24/195 (12%) Query: 70 RDVYKPAPVVKPTDDLSHAAKLLLETDLRSLPVGE-NKAEILGVISDMA--LLERVVAEE 126 RDVY V P D L+HA KL+L D+ LPV E +K + I+D+A L+ + + Sbjct: 11 RDVY----TVSPDDTLAHARKLMLTHDISRLPVVEGSKLRGIITITDIADALVRKYPSRP 66 Query: 127 FGKRKVEEFMTKDVITLGPDDTVAKALATMRDHGISRIPVVDEEGKLEGLVTLHDLIIRF 186 V E M +DV+T+ +V A + M H I +PVV +G LEG++T DL R+ Sbjct: 67 ANSIYVREVMARDVVTIEGTKSVKTAASLMLKHNIGGVPVVAPDGTLEGIITRTDL-TRY 125 Query: 187 IKPRFKAQYGELAGEKIPPFSMKL-REAMIKGVITIMPEATIREAVSTMKDNNIDGLVVV 245 + K L E + K RE I V+ +M + + G V++ Sbjct: 126 YSEKMKGV--NLVKEFMREIYAKARREHSIFYVLKLM-------------EIDATGKVLI 170 Query: 246 DENNKVVGILTVKDL 260 + K+VG++T +D+ Sbjct: 171 LDGGKLVGVITKRDI 185 >sp|Q58332|Y922_METJA HYPOTHETICAL PROTEIN MJ0922 >gi|2127741|pir||B64415 yhcV homolog - Methanococcus jannaschii >gi|1591595|gb|AAB98926.1| (U67535) conserved hypothetical protein [Methanococcus jannaschii] Length = 138 Score = 78.8 bits (191), Expect = 1e-13 Identities = 49/143 (34%), Positives = 81/143 (56%), Gaps = 18/143 (12%) Query: 131 KVEEFMTKDVITLGPDDTVAKALATMRDHGISRIPVVDEEGKLEGLVTLHDLIIRFIKPR 190 KV++ MTK+VIT + V +A M + IS +PV+D+E K+ G+VT D+ I+ + Sbjct: 9 KVKDVMTKNVITAKRHEGVVEAFEKMLKYKISSLPVIDDENKVIGIVTTTDIGYNLIRDK 68 Query: 191 FKAQYGELAGEKIPPFSMKLREAMIKGVITIMPEATIREAVSTM-----KDNNIDGLVVV 245 + + + + M K VITI +A+I EA+ M K+ I+ L VV Sbjct: 69 YTLE-------------TTIGDVMTKDVITIHEDASILEAIKKMDISGKKEEIINQLPVV 115 Query: 246 DENNKVVGILTVKDLLLPISRMV 268 D+NNK+VGI++ D++ IS+++ Sbjct: 116 DKNNKLVGIISDGDIIRTISKII 138 >sp|Q58629|YC32_METJA HYPOTHETICAL PROTEIN MJ1232 >gi|2128738|pir||G64453 conserved hypothetical protein MJ1232 - Methanococcus jannaschii >gi|1591864|gb|AAB99237.1| (U67564) conserved hypothetical protein [Methanococcus jannaschii] Length = 296 Score = 77.6 bits (188), Expect = 2e-13 Identities = 61/202 (30%), Positives = 96/202 (47%), Gaps = 37/202 (18%) Query: 83 DDLSH----AAKLLLETDLRSLPVGE---------NKAEILGVISDMALLERVV------ 123 D +SH ++K+ +E D + +G+ NK I G I + R++ Sbjct: 104 DTVSHEKCCSSKIHIEGDTKHFNIGDIIRVGPTYHNKIIINGKIIGRDDIHRILLIDVLG 163 Query: 124 AEEFGKRKVEEFMTKDVITLGPDDTVAKALATMRDHGISRIPVVDEEGKLEGLVTLHDLI 183 KV + K+V T+ P+ T+ + + IS PVVD + KL G+++LHD+ Sbjct: 164 VSSIPNIKVGDVGIKEVWTINPNCTLRETAKLFAEKYISGAPVVDND-KLVGVISLHDI- 221 Query: 184 IRFIKPRFKAQYGELAGEKIPPFSMKLREAMIKGVITIMPEATIREAVSTMKDNNIDGLV 243 E I K++E M + VITI + I +A+ M NN+ LV Sbjct: 222 ----------------AENIDNIDKKVKEVMRRDVITIHKDEKIYDALKIMNKNNVGRLV 265 Query: 244 VVDENNKVVGILTVKDLLLPIS 265 +VD+NNK+VGI+T D+L IS Sbjct: 266 IVDDNNKIVGIITRTDILKIIS 287 >pir||D69035 MJ1232 protein homolog MTH126 - Methanobacterium thermoautotrophicum (strain Delta H) >gi|2621166|gb|AAB84632.1| (AE000802) inosine-5'-monophosphate dehydrogenase related protein VII [Methanobacterium thermoautotrophicum] Length = 302 Score = 77.6 bits (188), Expect = 2e-13 Identities = 53/178 (29%), Positives = 88/178 (48%), Gaps = 22/178 (12%) Query: 90 KLLLETDLRSLPVGENKAEILGVI------SDMALLERVVAEEFGKRKVEEFMTKDVITL 143 KL L +R P NK + GV+ ++ LL+ K+ V E T+D++TL Sbjct: 134 KLDLGDRVRIGPTPVNKLVVDGVVVGRDDMDNIILLDTTAIRSIPKKTVAEVATRDLVTL 193 Query: 144 GPDDTVAKALATMRDHGISRIPVVDEEGKLEGLVTLHDLIIRFIKPRFKAQYGELAGEKI 203 PD TV +A A + GI P+V+++ +++G+VTL D+ AG + Sbjct: 194 APDITVKEAAARLSSLGIEGAPIVEDD-EVKGIVTLSDITASIA-----------AGTEF 241 Query: 204 PPFSMKLREAMIKGVITIMPEATIREAVSTMKDNNIDGLVVVDENNKVVGILTVKDLL 261 M++ + M K +IT+ + I +A+ M +NI L+V D + GI+T D+L Sbjct: 242 ----MQVSDIMSKNIITVKQDTMIADAIEVMNKHNIGRLIVTDSEGRPTGIITRTDIL 295 >pir||C69030 MJ1225 protein homolog MTH1222 - Methanobacterium thermoautotrophicum (strain Delta H) >gi|2622333|gb|AAB85711.1| (AE000890) inosine-5'-monophosphate dehydrogenase related protein I [Methanobacterium thermoautotrophicum] Length = 275 Score = 77.6 bits (188), Expect = 2e-13 Identities = 69/275 (25%), Positives = 135/275 (49%), Gaps = 24/275 (8%) Query: 1 MVGIQVQEVMTDRYAKIDINAPLSEAIGIIEKEDPDLILVFDDNV-----YKGVLTQ-DL 54 M + ++ +M++ ID + + +A+ +++K + +LV + N G++T+ D+ Sbjct: 1 MESMIIKNIMSEDPVCIDKDQNICDALRLMDKRNVSRLLVINTNSDHERELVGIVTEKDI 60 Query: 55 IIR----SHLKWDPTKAKVRDVYKPAPVV-KPTDDLSHAAKLLLETDLRSLPVGENKAEI 109 ++ + P+ V V P + +P D +AA ++LE ++ SLPV + EI Sbjct: 61 ALKLGSSRYGNMAPSHFHVSTVMTPELITAEPDMDAGNAASVMLENNIGSLPVLHD-GEI 119 Query: 110 LGVISDMALLERVVAEEFGKRKVEEFMTKDVITLGPDDTVAKALATMRDHGISRIPVVDE 169 +G+++ LL+ + K + M+ ++IT+ P + V A M D GI R+ V+ E Sbjct: 120 MGIVTKSDLLDICRGRAYEKYTAADVMSTEMITVSPAERVVHARRIMIDAGIGRLLVM-E 178 Query: 170 EGKLEGLVTLHDLIIRFIKPRFKAQYGELAGEKIPPFSMK---LREAMIKGVITIMPEAT 226 E +L G++T D+ R + +L ++ P ++ + + M + V TI E Sbjct: 179 EDELAGILTARDM------TRAVINFRKLVPDRHKPSRIRNLLVEDIMKQNVRTIEEETP 232 Query: 227 IREAVSTMKDNNIDGLVVVDENNKVVGILTVKDLL 261 + E S M + G V+ + +V GI+T D+L Sbjct: 233 VTEVASLMLETGYGGFPVIKQ--EVEGIVTKTDIL 265 >sp|P15889|YR33_THEPE HYPOTHETICAL 33.4 KD PROTEIN IN RIBOSOMAL RNA OPERON >gi|81092|pir||S08244 conserved hypothetical protein MJ1225 homolog - Thermofilum pendens >gi|48226|emb|CAA32944.1| (X14835) open reading frame 1 (300 AA) [Thermofilum pendens] Length = 300 Score = 76.5 bits (185), Expect = 5e-13 Identities = 61/227 (26%), Positives = 112/227 (48%), Gaps = 20/227 (8%) Query: 41 FDDNVYKGVLTQDLIIRSHLKWDPTKAKVRDVYKPAPVVKPTDDLSHAAKLLLETDLRSL 100 F+ +VYK + + LK+DP P V DL +L++E + +L Sbjct: 73 FNGDVYKALEQTGV---EFLKYDP------------PYVYTRSDLREVIELMVERGIGAL 117 Query: 101 PVGENKAEILGVISDMALLERVVAEEFGKRKVEEFMTKDVITLGPDDTVAKALATMRDHG 160 V + ++G++S+ ++ ++A KV+E MT +V+ L P D++ + + M + Sbjct: 118 AVVDEDLRVVGIVSERHVIS-LLANVETHVKVKEIMTSEVVYLSPMDSLFEGMRVMSERR 176 Query: 161 ISRIPVVDEEGKLEGLVTLHDLIIRFIKPRFKAQYGELAGEKIPPFSMKLREAMIKGVIT 220 I R+P+V E +L G+VT+ D++ + A+ E G + + L K V+ Sbjct: 177 IRRLPLVSGE-ELRGIVTIKDVLSYVSREDVLARLKE--GSRSAVYDTPLVYISSKPVLA 233 Query: 221 IMPEATIREAVSTMKDNNIDGLVVVDENNKVVGILTVKDLLLPISRM 267 + + + AVS MK + I G +VV + K GI+T +D+L + R+ Sbjct: 234 VEDDVDVGLAVSLMKKHGI-GALVVTHDGKPRGIVTERDVLTRLPRV 279 >pir||F69185 yhcV homolog MTH644 - Methanobacterium thermoautotrophicum (strain Delta H) >gi|2621725|gb|AAB85149.1| (AE000844) conserved protein [Methanobacterium thermoautotrophicum] Length = 157 Score = 76.1 bits (184), Expect = 6e-13 Identities = 46/150 (30%), Positives = 80/150 (52%), Gaps = 19/150 (12%) Query: 131 KVEEFMTKDVITLGPDDTVAKALATMRDHGISRIPVVDEEGKLEGLVTLHDLI------- 183 +V++ M DVIT+ ++ A +R++ IS PVVDE+GKL G+++ D++ Sbjct: 3 RVKDAMQSDVITVKRTSSIHDAARVLRENRISGAPVVDEDGKLVGIISEGDIMRLIEVHS 62 Query: 184 --IRFIKP----------RFKAQYGELAGEKIPPFSMKLREAMIKGVITIMPEATIREAV 231 + I P R K +Y E+A M++ E M V+T+ P A++ +A Sbjct: 63 PSLNLIMPSPLDLLELPLRMKHEYDEIARGIRKAAVMRVEEIMTPKVVTVPPHASVSDAA 122 Query: 232 STMKDNNIDGLVVVDENNKVVGILTVKDLL 261 M+ ++I L V+DEN ++ GI+T D++ Sbjct: 123 ELMERHDIKRLPVIDENGRLAGIITRGDII 152 >sp|P50100|IMDH_METKA PUTATIVE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (IMP DEHYDROGENASE) (IMPDH) (IMPD) (ORFX) >gi|1002715|gb|AAA92086.1| (U31567) similar to the inosine monophosphate dehydrogenase from Pyrococcus furiosus (SwissProt Accession Number P42851); orfX protein; Method: conceptual translation supplied by author [Methanopyrus kandleri] Length = 172 Score = 75.3 bits (182), Expect = 1e-12 Identities = 43/130 (33%), Positives = 72/130 (55%), Gaps = 12/130 (9%) Query: 132 VEEFMTKDVITLGPDDTVAKALATMRDHGISRIPVVDEEGKLEGLVTLHDLIIRFIKPRF 191 V E +DVIT P +T + MR+HGI + +V+E+ + G++T DL+I+ + Sbjct: 6 VGEVARRDVITGSPTETAVEIAYKMREHGIGSVVIVNEKDEPIGIITERDLVIKVVSQ-- 63 Query: 192 KAQYGELAGEKIPPFSMKLREAMIKGVITIMPEATIREAVSTMKDNNIDGLVVVDENNKV 251 G+ P + R+ M + VIT+ + + EAV M D I L +VD+N K+ Sbjct: 64 --------GKN--PDEVIARDIMSQPVITVEEDMEVNEAVKLMVDKGIRRLPIVDDNGKL 113 Query: 252 VGILTVKDLL 261 +GI+T++D+L Sbjct: 114 IGIVTMQDIL 123 >gi|11498454 conserved hypothetical protein [Archaeoglobus fulgidus] >gi|7429331|pir||H69355 conserved hypothetical protein MJ1225 homolog - Archaeoglobus fulgidus >gi|2649753|gb|AAB90389.1| (AE001045) conserved hypothetical protein [Archaeoglobus fulgidus] Length = 284 Score = 74.9 bits (181), Expect = 1e-12 Identities = 51/188 (27%), Positives = 97/188 (51%), Gaps = 7/188 (3%) Query: 79 VKPTDDLSHAAKLLLETDLRSLPVGENKAEILGVISDMALLERVVAEEFGKRKVEEFMTK 138 V +D L A + + E ++ P+ ++G+I++ +L+ + A ++MT Sbjct: 92 VNESDSLEEAVETMFEKNVGGCPIVNKDDVVVGIITERDILKYLGANRSIDGVASDYMTS 151 Query: 139 DVITLGPDDTVAKALATMRDHGISRIPVVDEEGKLEGLVTLHDLIIRF-IKPRFK-AQYG 196 VITL P D++ +A+ TM + + RIP++D +G L GL+T+ +++ F F+ G Sbjct: 152 SVITLRPKDSIERAMRTMIEKKLRRIPIID-DGILVGLITVREILRYFGTGEAFRMLTSG 210 Query: 197 ELAGEKIPPFSMKLRE---AMIKGVITIMPEATIREAVSTMKDNNIDGLVVVDENNKVVG 253 + P S L + K ++T +I + VS+M + G+ ++ EN K+ G Sbjct: 211 NIKDAIDKPISTILANDELLVYKDILTFPRNISISQLVSSMLEKGY-GVALIVENGKLEG 269 Query: 254 ILTVKDLL 261 I+T +DL+ Sbjct: 270 IITERDLI 277 Score = 72.2 bits (174), Expect = 1e-11 Identities = 48/147 (32%), Positives = 76/147 (51%), Gaps = 4/147 (2%) Query: 134 EFMTKDVITLGPDDTVAKALATMRDHGISRIPVVDEEGK-LEGLVTLHDLIIRFIK-PRF 191 E TKDV TL P T+ AL M RIP+ D K LEG+++ D + F P+F Sbjct: 3 EIATKDVFTLPPTSTLMNALKMMLRRNFRRIPIADPGTKRLEGIISATDFVNIFGGGPKF 62 Query: 192 KAQYGELAGEKIPPFSMKLREAMIKGVITIMPEATIREAVSTMKDNNIDGLVVVDENNKV 251 G G + + M + V+T+ ++ EAV TM + N+ G +V++++ V Sbjct: 63 GLIKGRYGGNLSAAVNEVVETIMEREVVTVNESDSLEEAVETMFEKNVGGCPIVNKDDVV 122 Query: 252 VGILTVKDLL--LPISRMVEKEARFYL 276 VGI+T +D+L L +R ++ A Y+ Sbjct: 123 VGIITERDILKYLGANRSIDGVASDYM 149 >sp|Q58622|YC25_METJA HYPOTHETICAL PROTEIN MJ1225 >gi|2128050|pir||H64452 conserved hypothetical protein MJ1225 - Methanococcus jannaschii >gi|1591856|gb|AAB99228.1| (U67563) conserved hypothetical protein [Methanococcus jannaschii] Length = 280 Score = 74.5 bits (180), Expect = 2e-12 Identities = 60/244 (24%), Positives = 122/244 (49%), Gaps = 9/244 (3%) Query: 19 INAPLSEAIGIIEKEDPDLILVFDDNVYKGVLTQDLIIRSHLKWDPTKAKVRDVYKPAPV 78 +NA ++ +GII D I+ F K L ++ R+ L VR++ + + Sbjct: 41 VNAGNNKVVGIITSMD---IVDFMGGGSKYNLIREKHERNFLA--AINEPVREIMEENVI 95 Query: 79 -VKPTDDLSHAAKLLLETDLRSLPVGENKAEILGVISDMALLERVVAEEFGKRKVEEFMT 137 +K D+ A + L ++ P+ ++ +++ +I++ ++ ++ + +++++T Sbjct: 96 TLKENADIDEAIETFLTKNVGGAPIVNDENQLISLITERDVIRALLDKIDENEVIDDYIT 155 Query: 138 KDVITLGPDDTVAKALATMRDHGISRIPVVDEEGKLEGLVTLHDLIIRFIKPRFKAQYGE 197 +DVI P + + TM +G R+PVV EG+L G++T D I+ + + + + Sbjct: 156 RDVIVATPGERLKDVARTMVRNGFRRLPVV-SEGRLVGIITSTD-FIKLLGSDWAFNHMQ 213 Query: 198 LAGEKIPPFSMKLREAMIKGVITIMPEATIREAVSTMKDNNIDGLVVVDENNKVVGILTV 257 G ++++ E M + VIT +++ M N+I L VVDEN ++ GI+T Sbjct: 214 -TGNVREITNVRMEEIMKRDVITAKEGDKLKKIAEIMVTNDIGALPVVDENLRIKGIITE 272 Query: 258 KDLL 261 KD+L Sbjct: 273 KDVL 276 >pir||C72264 IMP dehydrogenase (EC 1.1.1.205) - Thermotoga maritima (strain MSB8) >gi|4981907|gb|AAD36418.1|AE001789_3 (AE001789) inosine-5'-monophosphate dehydrogenase [Thermotoga maritima] Length = 482 Score = 73.7 bits (178), Expect = 3e-12 Identities = 54/175 (30%), Positives = 88/175 (49%), Gaps = 20/175 (11%) Query: 130 RKVEEFMTKDVITLGPDDTVAKALATMRDHGISRIPVVDEEGKLEGLVTLHDLIIRFIKP 189 +K E + D IT+ PD TV +A+ M ++ I +PVVDEEG+L GL+T D +RF K Sbjct: 83 KKTENGIIYDPITVTPDMTVKEAIDLMAEYKIGGLPVVDEEGRLVGLLTNRD--VRFEK- 139 Query: 190 RFKAQYGELAGEKIPPFSMKLREAMI--KGVITIMPEATIREAVSTMKDNNIDGLVVVDE 247 S K+++ M + +I P+ ++ +A + + I+ L +V + Sbjct: 140 ---------------NLSKKIKDLMTPREKLIVAPPDISLEKAKEILHQHRIEKLPLVSK 184 Query: 248 NNKVVGILTVKDLLLPISRMVEKEARFYLQLGGDASALSEFTRERIINDIKRFVD 302 +NK+VG++T+KD++ I L G A S T ER+ +K VD Sbjct: 185 DNKLVGLITIKDIMSVIEHPNAARDEKGRLLVGAAVGTSPETMERVEKLVKAGVD 239 >pir||C75148 hypothetical protein PAB2118 - Pyrococcus abyssi (strain Orsay) >gi|5457776|emb|CAB49266.1| (AJ248284) hypothetical protein [Pyrococcus abyssi] Length = 282 Score = 73.0 bits (176), Expect = 6e-12 Identities = 73/280 (26%), Positives = 125/280 (44%), Gaps = 28/280 (10%) Query: 4 IQVQEVMTDRYAKIDINAPLSEAIGIIEKEDPDLILVFDDNVYKGVLTQDLIIRSHLKWD 63 ++V+ +MT I + A + A+ I +K V + +G L + I+ L Sbjct: 1 MKVKTIMTPNPVTITLPATRNYALDIFKKHKVRSFPVVNR---EGKLVGIISIKRVLTNP 57 Query: 64 PTKAKVRDVYKPAPVVKPTDDLSHAAKLLLETDLRSLPVGENKAEILGVISDMALLERVV 123 + V + P VK DDL AA+L+LE D R + V +N+ + +G+++ ++ R + Sbjct: 58 DEEQLAMLVKRDVPTVKENDDLKKAARLMLEHDYRRVVVVDNEGKPVGILTVGDIVRRYL 117 Query: 124 A--EEFGKRKVEEFMTKDVITLGPDDTVAKALATMRDHGISRIPVVDEEGKLEGLVTLHD 181 A E++ + ++E + + V + + AL + +PVVD+ G+L G++ D Sbjct: 118 AKTEKYKEVEIEPYYQRHVSIVWKGTPLKAALKALLLSNAMALPVVDDNGELIGIIDETD 177 Query: 182 L-----IIRFIKPRFKAQYGE----------LAGEKIPPFSMKL-----REAMIKGVITI 221 L I+R +K A E L EK F ++L E M K VI Sbjct: 178 LLRDSEIVRIMKSTELAASSEEEWILESHPTLLFEK---FELQLPNKPVEEIMTKDVIVA 234 Query: 222 MPEATIREAVSTMKDNNIDGLVVVDENNKVVGILTVKDLL 261 P T+ E M I+ L V+ +VG++ DLL Sbjct: 235 TPHMTVYEVAKKMVKYRIEQLPVIKGEGDLVGLIRDFDLL 274 >gb|AAK43302.1| Conserved hypothetical protein [Sulfolobus solfataricus] Length = 277 Score = 72.6 bits (175), Expect = 7e-12 Identities = 61/250 (24%), Positives = 127/250 (50%), Gaps = 29/250 (11%) Query: 38 ILVFDDNVYKGVLTQDLI--IRSHLK--------WDPTKAKVRDVYKPAPV-VKPTDDLS 86 I+V ++ + + T+DL+ + S+ K + + + D P PV V T D Sbjct: 35 IIVANEKIEGLLTTRDLLSTVESYCKDSCSQGDLYHISTTPIIDYMTPNPVTVYNTSDEF 94 Query: 87 HAAKLLLETDLRSLPVGENKAEILGVISD--MALLERVVAEEFGKRKVEEFMTKDVITLG 144 A +++ + SLPV + + +G++++ LL + + E F V+ FM+ V T+ Sbjct: 95 TAINIMVTRNFGSLPVVDINDKPVGIVTEREFLLLYKDLDEIF---PVKVFMSTKVQTIY 151 Query: 145 PDDTVAKALATMRDHGISRIPVVDEEGKLEGLVTLHDLIIRFIKPRFKAQYGELAGEKIP 204 + + +A+ M G R+PV+D++ K+ G+VT+ + I + K A +K+ Sbjct: 152 KEVRLDQAVKLMLRRGFRRLPVIDDDNKVVGIVTVVNAIKQLAK----------AVDKLD 201 Query: 205 P---FSMKLREAMIKGVITIMPEATIREAVSTMKDNNIDGLVVVDENNKVVGILTVKDLL 261 P + +++ M+ ++TI A++ A + M I L++++++N + GI+T +DLL Sbjct: 202 PDYFYGKVVKDVMVTNLVTIDELASVNRAAAEMIVKRIGSLLILNKDNTIRGIITERDLL 261 Query: 262 LPISRMVEKE 271 + + ++ E Sbjct: 262 IALHHILVME 271 >pir||H72780 hypothetical protein APE0233 - Aeropyrum pernix (strain K1) >gi|5103625|dbj|BAA79146.1| (AP000058) 340aa long hypothetical protein [Aeropyrum pernix] Length = 340 Score = 72.6 bits (175), Expect = 7e-12 Identities = 52/194 (26%), Positives = 103/194 (52%), Gaps = 7/194 (3%) Query: 79 VKPTDDLSHAAKLLLETDLRSLPVGENKAEILGVISDMALLERVVAEEFGKRKVEEFMTK 138 V +DDL ++++ + LPV + + GVI++ +L R+ F K KV ++MT Sbjct: 152 VSVSDDLDTILRIMVGEGIGFLPVLYDDGTLHGVITERNILGRIADIPFDK-KVGDYMTA 210 Query: 139 DVITLGPDDTVAKALATMRDHGISRIPVVDEE-GKLEGLVTLHDLIIRFIKPRFKAQYGE 197 ++ + P+ + +A+ +M +G R+ V+ G+++G++T D++ F +A Sbjct: 211 TIVGVDPEAPLKEAMRSMVTYGFRRLLVISSSTGEIKGVITAKDIVAYF--GEHEAFKNA 268 Query: 198 LAGEKIPPFSMKLREAMIKGVITIMPEATIREAVSTMKDNNIDGLVVVDENNKVVGILTV 257 +G+ S+ + M V TI +A++ +A M + +D L+VVD + GI+T Sbjct: 269 PSGKVSEAISIPVYMVMSPEVYTIDEKASVADAARRMVELGVDSLIVVD-GGEAKGIITE 327 Query: 258 KDLLLPISRMVEKE 271 +D+L ++ +VE E Sbjct: 328 RDVL--VASVVEGE 339 >sp|O67820|IMDH_AQUAE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (IMP DEHYDROGENASE) (IMPDH) (IMPD) >gi|7427683|pir||H70473 IMP dehydrogenase (EC 1.1.1.205) - Aquifex aeolicus >gi|2984252|gb|AAC07779.1| (AE000768) inosine monophosphate dehydrogenase [Aquifex aeolicus] Length = 490 Score = 71.8 bits (173), Expect = 1e-11 Identities = 51/140 (36%), Positives = 74/140 (52%), Gaps = 18/140 (12%) Query: 124 AEEFGK-RKVEEFMTKDVITLGPDDTVAKALATMRDHGISRIPVVDEEGKLEGLVTLHDL 182 AEE K +K E M + +T+ PD V +AL M + IS +PVVDEE KL G++T DL Sbjct: 83 AEEVEKVKKSESGMIINPVTVKPDTRVKEALDIMAKYKISGVPVVDEERKLIGILTNRDL 142 Query: 183 IIRFIKPRFKAQYGELAGEKIPPFSMKLREAMIKGVITIMPEA-TIREAVSTMKDNNIDG 241 RFIKP +S + E M K + PE T+ EA + I+ Sbjct: 143 --RFIKPE--------------DYSKPVSEFMTKENLITAPEGITLDEAEEIFRKYKIEK 186 Query: 242 LVVVDENNKVVGILTVKDLL 261 L +VD+ K+ G++T+KD++ Sbjct: 187 LPIVDKEGKIKGLITIKDIV 206 >pir||C71188 conserved hypothetical protein MJ1225 homolog - Pyrococcus horikoshii >gi|3258215|dbj|BAA30898.1| (AP000007) 285aa long hypothetical protein [Pyrococcus horikoshii] Length = 285 Score = 71.0 bits (171), Expect = 2e-11 Identities = 73/283 (25%), Positives = 125/283 (43%), Gaps = 28/283 (9%) Query: 1 MVGIQVQEVMTDRYAKIDINAPLSEAIGIIEKEDPDLILVFDDNVYKGVLTQDLIIRSHL 60 M+ ++V+ +MT I + A + A+ + +K V + +G L + ++ L Sbjct: 1 MIWVRVKTIMTQNPVTITLPATRNYALELFKKYKVRSFPVVNK---EGKLVGIISVKRIL 57 Query: 61 KWDPTKAKVRDVYKPAPVVKPTDDLSHAAKLLLETDLRSLPVGENKAEILGVISDMALLE 120 + V + PVVK D L AAKL+LE D R + V ++K + +G+++ ++ Sbjct: 58 VNPDEEQLAMLVKRDVPVVKENDTLKKAAKLMLEYDYRRVVVVDSKGKPVGILTVGDIIR 117 Query: 121 RVVA--EEFGKRKVEEFMTKDVITLGPDDTVAKALATMRDHGISRIPVVDEEGKLEGLVT 178 R A E++ ++E + + V + + AL + +PVVD EG L G+V Sbjct: 118 RYFAKSEKYKGVEIEPYYQRYVSIVWEGTPLKAALKALLLSNSMALPVVDSEGNLVGIVD 177 Query: 179 LHDL-----IIRFIKPRFKAQYGE----------LAGEKIPPFSMKL-----REAMIKGV 218 DL I+R +K A E L EK F ++L E M + V Sbjct: 178 ETDLLRDSEIVRIMKSTELAASSEEEWILESHPTLLFEK---FELQLPNKPVAEIMTRDV 234 Query: 219 ITIMPEATIREAVSTMKDNNIDGLVVVDENNKVVGILTVKDLL 261 I P T+ E M +I+ L V+ ++G++ DLL Sbjct: 235 IVATPHMTVHEVALKMAKYSIEQLPVIRGEGDLIGLIRDFDLL 277 >pir||B72265 hypothetical protein TM1354 - Thermotoga maritima (strain MSB8) >gi|4981914|gb|AAD36425.1|AE001789_10 (AE001789) inosine-5-monophosphate dehydrogenase-related protein [Thermotoga maritima] Length = 321 Score = 71.0 bits (171), Expect = 2e-11 Identities = 37/105 (35%), Positives = 62/105 (58%), Gaps = 1/105 (0%) Query: 79 VKPTDDLSHAAKLLLETDLRSLPVGENKAEILGVISDMALLERVVAEEFGKRKVEEFMTK 138 V P L H +++ + +PV ++K ++G++S ++ + + + K VE+ MTK Sbjct: 29 VTPDKTLLHVKEIMRIKRISGVPVVDDKKRVVGIVSLEDII-KALEGSYIKDSVEKRMTK 87 Query: 139 DVITLGPDDTVAKALATMRDHGISRIPVVDEEGKLEGLVTLHDLI 183 +V+ L DT+ A+ T +G R PVVD+EGKL G+VT HD+I Sbjct: 88 NVVCLKETDTLQDAVKTFEKYGYGRFPVVDDEGKLVGIVTKHDII 132 Database: ./suso.pep Posted date: Jul 6, 2001 5:57 PM Number of letters in database: 840,471 Number of sequences in database: 2977 Database: /banques/blast2/nr.pep Posted date: Dec 14, 2000 12:46 PM Number of letters in database: 188,266,275 Number of sequences in database: 595,510 Lambda K H 0.321 0.141 0.394 Gapped Lambda K H 0.270 0.0470 0.230 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 138639362 Number of Sequences: 2977 Number of extensions: 5939473 Number of successful extensions: 17748 Number of sequences better than 1.0e-10: 31 Number of HSP's better than 0.0 without gapping: 6 Number of HSP's successfully gapped in prelim test: 25 Number of HSP's that attempted gapping in prelim test: 17557 Number of HSP's gapped (non-prelim): 77 length of query: 392 length of database: 189,106,746 effective HSP length: 57 effective length of query: 335 effective length of database: 154,992,987 effective search space: 51922650645 effective search space used: 51922650645 T: 11 A: 40 X1: 16 ( 7.4 bits) X2: 38 (14.8 bits) X3: 64 (24.9 bits) S1: 41 (21.8 bits) S2: 166 (69.1 bits)