BLASTP 2.0.10 [Aug-26-1999]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= PAB0961 (PAB0961) DE:dehydrogenase
         (392 letters)

Database: ./suso.pep; /banques/blast2/nr.pep
           598,487 sequences; 189,106,746 total letters

Searching..................................................done

                                                                   Score     E
Sequences producing significant alignments:                        (bits)  Value

pir||G75056 dehydrogenase PAB0961 - Pyrococcus abyssi (strain Or...   771  0.0
pir||D71175 hypothetical protein PH0600 - Pyrococcus horikoshii ...   733  0.0
pir||C69276 coenzyme F420--quinone oxidoreductase (EC 1.6.5.-) 4...   189  5e-47
gi|11497827 conserved hypothetical protein [Archaeoglobus fulgid...   189  5e-47
gb|AAG19915.1| (AE005075) Vng1663c [Halobacterium sp. NRC-1]          171  9e-42
sp|Q58799|YE04_METJA HYPOTHETICAL PROTEIN MJ1404 >gi|2128840|pir...   131  1e-29
emb|CAC11941.1| (AL445065) conserved hypothetical protein [Therm...    91  2e-17
sp|Q59011|IMDH_METJA INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (IMP...    90  5e-17
gb|AAK42850.1| Conserved hypothetical protein [Sulfolobus solfat...    88  2e-16
sp|O58045|IMDH_PYRHO INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (IMP...    86  8e-16
sp|P42851|IMDH_PYRFU INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (IMP...    84  2e-15
gb|AAK40395.1| Conserved hypothetical protein [Sulfolobus solfat...    83  5e-15
pir||D69030 MJ1225-related protein MTH1223 - Methanobacterium th...    82  1e-14
pir||E75015 IMP dehydrogenase (EC 1.1.1.205) PAB1250 - Pyrococcu...    80  3e-14
pir||F72780 hypothetical protein APE0231 - Aeropyrum pernix (str...    80  6e-14
sp|Q58332|Y922_METJA HYPOTHETICAL PROTEIN MJ0922 >gi|2127741|pir...    79  1e-13
sp|Q58629|YC32_METJA HYPOTHETICAL PROTEIN MJ1232 >gi|2128738|pir...    78  2e-13
pir||D69035 MJ1232 protein homolog MTH126 - Methanobacterium the...    78  2e-13
pir||C69030 MJ1225 protein homolog MTH1222 - Methanobacterium th...    78  2e-13
sp|P15889|YR33_THEPE HYPOTHETICAL 33.4 KD PROTEIN IN RIBOSOMAL R...    76  5e-13
pir||F69185 yhcV homolog MTH644 - Methanobacterium thermoautotro...    76  6e-13
sp|P50100|IMDH_METKA PUTATIVE INOSINE-5'-MONOPHOSPHATE DEHYDROGE...    75  1e-12
gi|11498454 conserved hypothetical protein [Archaeoglobus fulgid...    75  1e-12
sp|Q58622|YC25_METJA HYPOTHETICAL PROTEIN MJ1225 >gi|2128050|pir...    75  2e-12
pir||C72264 IMP dehydrogenase (EC 1.1.1.205) - Thermotoga mariti...    74  3e-12
pir||C75148 hypothetical protein PAB2118 - Pyrococcus abyssi (st...    73  6e-12
gb|AAK43302.1| Conserved hypothetical protein [Sulfolobus solfat...    73  7e-12
pir||H72780 hypothetical protein APE0233 - Aeropyrum pernix (str...    73  7e-12
sp|O67820|IMDH_AQUAE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (IMP...    72  1e-11
pir||C71188 conserved hypothetical protein MJ1225 homolog - Pyro...    71  2e-11
pir||B72265 hypothetical protein TM1354 - Thermotoga maritima (s...    71  2e-11

>pir||G75056 dehydrogenase PAB0961 - Pyrococcus abyssi (strain Orsay)
           >gi|5458861|emb|CAB50348.1| (AJ248287) dehydrogenase
           [Pyrococcus abyssi]
           Length = 392
           
 Score =  771 bits (1968), Expect = 0.0
 Identities = 392/392 (100%), Positives = 392/392 (100%)

Query: 1   MVGIQVQEVMTDRYAKIDINAPLSEAIGIIEKEDPDLILVFDDNVYKGVLTQDLIIRSHL 60
           MVGIQVQEVMTDRYAKIDINAPLSEAIGIIEKEDPDLILVFDDNVYKGVLTQDLIIRSHL
Sbjct: 1   MVGIQVQEVMTDRYAKIDINAPLSEAIGIIEKEDPDLILVFDDNVYKGVLTQDLIIRSHL 60

Query: 61  KWDPTKAKVRDVYKPAPVVKPTDDLSHAAKLLLETDLRSLPVGENKAEILGVISDMALLE 120
           KWDPTKAKVRDVYKPAPVVKPTDDLSHAAKLLLETDLRSLPVGENKAEILGVISDMALLE
Sbjct: 61  KWDPTKAKVRDVYKPAPVVKPTDDLSHAAKLLLETDLRSLPVGENKAEILGVISDMALLE 120

Query: 121 RVVAEEFGKRKVEEFMTKDVITLGPDDTVAKALATMRDHGISRIPVVDEEGKLEGLVTLH 180
           RVVAEEFGKRKVEEFMTKDVITLGPDDTVAKALATMRDHGISRIPVVDEEGKLEGLVTLH
Sbjct: 121 RVVAEEFGKRKVEEFMTKDVITLGPDDTVAKALATMRDHGISRIPVVDEEGKLEGLVTLH 180

Query: 181 DLIIRFIKPRFKAQYGELAGEKIPPFSMKLREAMIKGVITIMPEATIREAVSTMKDNNID 240
           DLIIRFIKPRFKAQYGELAGEKIPPFSMKLREAMIKGVITIMPEATIREAVSTMKDNNID
Sbjct: 181 DLIIRFIKPRFKAQYGELAGEKIPPFSMKLREAMIKGVITIMPEATIREAVSTMKDNNID 240

Query: 241 GLVVVDENNKVVGILTVKDLLLPISRMVEKEARFYLQLGGDASALSEFTRERIINDIKRF 300
           GLVVVDENNKVVGILTVKDLLLPISRMVEKEARFYLQLGGDASALSEFTRERIINDIKRF
Sbjct: 241 GLVVVDENNKVVGILTVKDLLLPISRMVEKEARFYLQLGGDASALSEFTRERIINDIKRF 300

Query: 301 VDGYADLLGNEGIIYLYIRRFNEKFRGVHLYQARMRVVTDRGVFIARGETWGAIQAVHDA 360
           VDGYADLLGNEGIIYLYIRRFNEKFRGVHLYQARMRVVTDRGVFIARGETWGAIQAVHDA
Sbjct: 301 VDGYADLLGNEGIIYLYIRRFNEKFRGVHLYQARMRVVTDRGVFIARGETWGAIQAVHDA 360

Query: 361 IRAIERQLLQKAELERDIRYAKRFIEKLELWR 392
           IRAIERQLLQKAELERDIRYAKRFIEKLELWR
Sbjct: 361 IRAIERQLLQKAELERDIRYAKRFIEKLELWR 392


>pir||D71175 hypothetical protein PH0600 - Pyrococcus horikoshii
           >gi|3257006|dbj|BAA29689.1| (AP000002) 392aa long
           hypothetical protein [Pyrococcus horikoshii]
           Length = 392
           
 Score =  733 bits (1873), Expect = 0.0
 Identities = 366/392 (93%), Positives = 386/392 (98%)

Query: 1   MVGIQVQEVMTDRYAKIDINAPLSEAIGIIEKEDPDLILVFDDNVYKGVLTQDLIIRSHL 60
           MVGIQVQEVMTD+YAKIDI+APLSEAIGIIEKEDPDLILVFDDNVYKGVLTQDLIIRSHL
Sbjct: 1   MVGIQVQEVMTDKYAKIDISAPLSEAIGIIEKEDPDLILVFDDNVYKGVLTQDLIIRSHL 60

Query: 61  KWDPTKAKVRDVYKPAPVVKPTDDLSHAAKLLLETDLRSLPVGENKAEILGVISDMALLE 120
           KWDPTKAKVRD+YKPAPVVKPTDDLSHAAKLLLETDLRSLPVGENKAEI+GVISD+ALLE
Sbjct: 61  KWDPTKAKVRDIYKPAPVVKPTDDLSHAAKLLLETDLRSLPVGENKAEIIGVISDIALLE 120

Query: 121 RVVAEEFGKRKVEEFMTKDVITLGPDDTVAKALATMRDHGISRIPVVDEEGKLEGLVTLH 180
           RVVAEEFGK+KVEEFMTKDVITL PDDTVAKALA MRDHGISRIP+V+EEGKLEGLVTLH
Sbjct: 121 RVVAEEFGKKKVEEFMTKDVITLTPDDTVAKALAVMRDHGISRIPIVNEEGKLEGLVTLH 180

Query: 181 DLIIRFIKPRFKAQYGELAGEKIPPFSMKLREAMIKGVITIMPEATIREAVSTMKDNNID 240
           DLI+RFIKPRFKAQ GEL GEKIPPFSMKLREAMI+GVITI+P AT+REAV+TMKDN+ID
Sbjct: 181 DLILRFIKPRFKAQTGELVGEKIPPFSMKLREAMIRGVITILPTATVREAVATMKDNDID 240

Query: 241 GLVVVDENNKVVGILTVKDLLLPISRMVEKEARFYLQLGGDASALSEFTRERIINDIKRF 300
           GLVVVDE NKVVGILTVKDLLLPISRMVEKEA+FYLQLGGDASALS+FTRERIINDIK+F
Sbjct: 241 GLVVVDEGNKVVGILTVKDLLLPISRMVEKEAKFYLQLGGDASALSDFTRERIINDIKKF 300

Query: 301 VDGYADLLGNEGIIYLYIRRFNEKFRGVHLYQARMRVVTDRGVFIARGETWGAIQAVHDA 360
           VDGY+DLLGNEGIIYLYIRRFNEKFRGVHLYQARMR+VTD+GVFIARGETWGAIQAVHDA
Sbjct: 301 VDGYSDLLGNEGIIYLYIRRFNEKFRGVHLYQARMRIVTDKGVFIARGETWGAIQAVHDA 360

Query: 361 IRAIERQLLQKAELERDIRYAKRFIEKLELWR 392
           IRAIERQLLQKAELERDIRYAKRFIEKLELWR
Sbjct: 361 IRAIERQLLQKAELERDIRYAKRFIEKLELWR 392


>pir||C69276 coenzyme F420--quinone oxidoreductase (EC 1.6.5.-) 41K chain
           [validated] - Archaeoglobus fulgidus
           Length = 390
           
 Score =  189 bits (475), Expect = 5e-47
 Identities = 122/391 (31%), Positives = 216/391 (55%), Gaps = 17/391 (4%)

Query: 6   VQEVMTDRYAKIDINAPLSEAIGIIEKEDPD---LILVFDDNVYKGVLTQDLIIRSHLKW 62
           ++E++ D +  I+ N  +S+   ++EK D D    ILV +D    GV+ +  +IR  +  
Sbjct: 6   LKELIRDDFEVINANETVSKLFPMLEKLDRDKANAILVEEDGKIVGVVREKDLIRGSVLK 65

Query: 63  DPTKAKVRDVYKPAPVVKPTD-DLSHAAKLLLE--TDLRSLPVGENKAEILGVISDMALL 119
           +P + KV+ +      +   + D    A+  +E  T    + + + +  ++ +   ++ L
Sbjct: 66  NPHETKVKSLLVRTGKIDLNELDPYKVARRFVEDSTPFVIVQIDDKRVGVIYINDFLSAL 125

Query: 120 ERVVAEEFGKRKVEEFMTKDVITLGPDDTVAKALATMRDHGISRIPVVDEEGKLEGLVTL 179
           +    +EF   KV E M  +VIT+   D+ AKAL+ MR HGI R+ VVDE  K+ G++T 
Sbjct: 126 K----DEFKDVKVREVMNPEVITVRRFDSAAKALSVMRTHGIDRVVVVDENNKVIGILTG 181

Query: 180 HDLIIRFIKPRFKAQYGELAGEKIPPFSMKLREAMIKGVITIMPEATIREAVSTMKDNNI 239
            D++ R I PR +A+ G+ +GEK    S+ +   M   V+++    ++ E +  M +N I
Sbjct: 182 KDVVDRVISPRKRARMGDSSGEKEKTLSIMVESIMSSPVVSVSRNDSVAEVIDLMVENRI 241

Query: 240 DGLVVVDENNKVVGILTVKDLLLPISRMVEKEAR--FYLQLGGDASALSEFTRERIINDI 297
              VVV  +    GI+  KD+L      ++KE+R  F +Q+      L EF RE I+ D+
Sbjct: 242 SS-VVVTRDGLPDGIVIKKDIL---EYYLKKESRKEFNVQISTADITLDEFDREAILEDV 297

Query: 298 KRFVDGYADLLGNEGIIYLYIRRFNEKFRGVHLYQARMRVVTDRGVFIARGETWGAIQAV 357
           ++ +  ++D LG E  +++YI+R  E FR + L   R+++ +++G F+  GE+WG   AV
Sbjct: 298 EKLMRKFSDFLG-ESFLFIYIKRHKEHFRNLPLIHVRLKLASEKGNFMVSGESWGVEYAV 356

Query: 358 HDAIRAIERQLLQKAELERDIRYAKRFIEKL 388
           H A++ +ER++L++ EL  D R  KRF E++
Sbjct: 357 HVALKKLEREILKEKELLEDKRMIKRFYEEV 387


>gi|11497827 conserved hypothetical protein [Archaeoglobus fulgidus]
           >gi|2650431|gb|AAB91022.1| (AE001091) conserved
           hypothetical protein [Archaeoglobus fulgidus]
           Length = 393
           
 Score =  189 bits (475), Expect = 5e-47
 Identities = 122/391 (31%), Positives = 216/391 (55%), Gaps = 17/391 (4%)

Query: 6   VQEVMTDRYAKIDINAPLSEAIGIIEKEDPD---LILVFDDNVYKGVLTQDLIIRSHLKW 62
           ++E++ D +  I+ N  +S+   ++EK D D    ILV +D    GV+ +  +IR  +  
Sbjct: 9   LKELIRDDFEVINANETVSKLFPMLEKLDRDKANAILVEEDGKIVGVVREKDLIRGSVLK 68

Query: 63  DPTKAKVRDVYKPAPVVKPTD-DLSHAAKLLLE--TDLRSLPVGENKAEILGVISDMALL 119
           +P + KV+ +      +   + D    A+  +E  T    + + + +  ++ +   ++ L
Sbjct: 69  NPHETKVKSLLVRTGKIDLNELDPYKVARRFVEDSTPFVIVQIDDKRVGVIYINDFLSAL 128

Query: 120 ERVVAEEFGKRKVEEFMTKDVITLGPDDTVAKALATMRDHGISRIPVVDEEGKLEGLVTL 179
           +    +EF   KV E M  +VIT+   D+ AKAL+ MR HGI R+ VVDE  K+ G++T 
Sbjct: 129 K----DEFKDVKVREVMNPEVITVRRFDSAAKALSVMRTHGIDRVVVVDENNKVIGILTG 184

Query: 180 HDLIIRFIKPRFKAQYGELAGEKIPPFSMKLREAMIKGVITIMPEATIREAVSTMKDNNI 239
            D++ R I PR +A+ G+ +GEK    S+ +   M   V+++    ++ E +  M +N I
Sbjct: 185 KDVVDRVISPRKRARMGDSSGEKEKTLSIMVESIMSSPVVSVSRNDSVAEVIDLMVENRI 244

Query: 240 DGLVVVDENNKVVGILTVKDLLLPISRMVEKEAR--FYLQLGGDASALSEFTRERIINDI 297
              VVV  +    GI+  KD+L      ++KE+R  F +Q+      L EF RE I+ D+
Sbjct: 245 SS-VVVTRDGLPDGIVIKKDIL---EYYLKKESRKEFNVQISTADITLDEFDREAILEDV 300

Query: 298 KRFVDGYADLLGNEGIIYLYIRRFNEKFRGVHLYQARMRVVTDRGVFIARGETWGAIQAV 357
           ++ +  ++D LG E  +++YI+R  E FR + L   R+++ +++G F+  GE+WG   AV
Sbjct: 301 EKLMRKFSDFLG-ESFLFIYIKRHKEHFRNLPLIHVRLKLASEKGNFMVSGESWGVEYAV 359

Query: 358 HDAIRAIERQLLQKAELERDIRYAKRFIEKL 388
           H A++ +ER++L++ EL  D R  KRF E++
Sbjct: 360 HVALKKLEREILKEKELLEDKRMIKRFYEEV 390


>gb|AAG19915.1| (AE005075) Vng1663c [Halobacterium sp. NRC-1]
           Length = 380
           
 Score =  171 bits (430), Expect = 9e-42
 Identities = 108/387 (27%), Positives = 203/387 (51%), Gaps = 12/387 (3%)

Query: 4   IQVQEVMTDRYAKIDINAPLSEAIGIIEKEDPDLILVFDDNVYKGVLTQDLIIRSHLKWD 63
           + + ++  + Y ++D    L +   + E+E+P  ++V +   Y GV+T+  +I+SH+  D
Sbjct: 1   MDISDIAANDYVEVDAEQRLGKVRSLFERENPKGVIVTEAGAYDGVITERQLIQSHIGDD 60

Query: 64  PTKAKVRDVYKPAPVVKPTDDLSHAAKLLLETDLRSLPVGENKAEILGVISDMALLERVV 123
               +V  +   AP V  T+D+   A++L+E   +  PV E    + GVI++ A+L+ V+
Sbjct: 61  ---TRVAAMVTDAPKVSRTEDVRETARMLVEGGTKIAPVFE-AGSLWGVITEDAILDAVL 116

Query: 124 AEEFGKRKVEEFMTKDVITLGPDDTVAKALATMRDHGISRIPVVDEEGKLEGLVTLHDLI 183
           A       V +  T+ V+T+  DD++ + +  +R+HGISR+PVVD+ G L G+VT +D++
Sbjct: 117 AN-LDALDVRDIYTEHVVTVDEDDSMGRVINLLREHGISRLPVVDDAGLLSGIVTRYDIV 175

Query: 184 IRFIKPRFKAQYGELAGEKIPPFSMKLREAMIKGVITIMPEATIREAVSTMKDNNIDGLV 243
              ++   K   G+ +GE      + + + M   V T   + ++R+AV  M  ++  G++
Sbjct: 176 DFVVRDTEKTTVGDRSGEIERLLDLPVSDEMTSPVKTASFDDSVRDAVDDMLAHDYSGVI 235

Query: 244 VV--DENNKVVGILTVKDLLLPISRMVEKEARFYLQLGGDASALSEFTRERIINDIKRFV 301
           V   D+   V GILT  D+L  +S   E+     +    +   L   +R+ +   I+  V
Sbjct: 236 VTPDDDERAVGGILTKTDVLRALSYTEEEHLDVQIT---NIDLLDTLSRQEVRERIENVV 292

Query: 302 DGYADLLGNEGIIYLYIRRFNEKFRGVHLYQARMRVVTDRGVFIARGETWGAIQAVHDAI 361
             Y D+  +    ++ + +  EK RG  L Q+++R+ T++G     GE +GA  + H A+
Sbjct: 293 AKYGDMDVHHA--HVRLSKHKEKLRGTPLIQSQIRLRTNKGQIAGTGEGYGADNSFHVAL 350

Query: 362 RAIERQLLQKAELERDIRYAKRFIEKL 388
             +ER +L+   +E D  Y  + + KL
Sbjct: 351 DKLERNVLELKGIEHDEEYEGQLLRKL 377


>sp|Q58799|YE04_METJA HYPOTHETICAL PROTEIN MJ1404 >gi|2128840|pir||C64475 hypothetical
           protein MJ1404 - Methanococcus jannaschii
           >gi|1592053|gb|AAB99421.1| (U67581) M. jannaschii
           predicted coding region MJ1404 [Methanococcus
           jannaschii]
           Length = 421
           
 Score =  131 bits (326), Expect = 1e-29
 Identities = 108/397 (27%), Positives = 193/397 (48%), Gaps = 41/397 (10%)

Query: 1   MVGIQVQEVMTDRYAKIDINAPLSEAIGIIEKEDPDLILVFDDN----VYKGVLTQDLII 56
           M+   V+E+MT     +  + P+S+A+GI+E+     ++V D       Y  +  +DL++
Sbjct: 4   MLNEPVKEIMTKDVVTVTPDTPVSKALGIMEENGFHHLIVVDKKDGKEEYYLISMRDLLL 63

Query: 57  RSHLKWDPTKAKVRDVYKPAPVVKPTDDLSHAAKLLLETDLRSLPVGENKAEILGVISDM 116
            S      T  +VR +   A  V        A   +L++  R+ P+  N  +++G+I+D 
Sbjct: 64  ASS-----TDEEVRSLMYKAHCVHEDTPFLDAVCEMLDSGQRAAPIVNNVGKMVGIITDY 118

Query: 117 ALLERVVAEEFGK-RKVEEFMTKDVITLGPDDTVAKALATMRDHGISRIPVVDEEGKLEG 175
            ++ R    +  K  KV + MT++VIT+  +D++ KA A MRD+ I R+ VVD+EG   G
Sbjct: 119 DIMARAAKSKIMKDTKVTKIMTRNVITINENDSIGKARALMRDNNIGRLVVVDDEGNPVG 178

Query: 176 LVTLHDLIIRFIKPRFKAQYGELAGEKIPPFSMKLREAMIKGVITIMPEATIREAVSTMK 235
           +VT  D++ +  KP+ K   GE  GEK+P     +R  M   +IT+  +A+  +A   M+
Sbjct: 179 MVTEVDILKKVFKPKKKMTAGEFKGEKVPRMGQPVRLIMNTPLITVDVDASAADAARVMQ 238

Query: 236 DNNIDGLVVVDENNKVVGILTVKDLLLPISRMVEKEARFYLQLGGDASALSEFTRERII- 294
           + +I G+ VV +   + GI+T  D++  I+ + +K A   ++L G      +   ERII 
Sbjct: 239 EYDIRGVPVV-KGKSLRGIVTRLDIIKYIADL-KKGAMIEIELHGMLDPEFKDLAERIIA 296

Query: 295 NDIKRFVDGYADLLGNEGIIYLYIRRFNEKFRGVHLYQARMRVVTDRGVFIARG------ 348
            ++K+ V       G    I + I++  +K  GV  Y+    V T   +++  G      
Sbjct: 297 TEVKKMVKH----AGKIHWIKITIKKERDK-GGVPYYRITTYVKTPNKLYVGEGRPKASL 351

Query: 349 -----------------ETWGAIQAVHDAIRAIERQL 368
                            E W  I  + +++ ++ RQL
Sbjct: 352 PNKLEAEGEDIAYVSEHERWEFIDVLKESLESVLRQL 388


>emb|CAC11941.1| (AL445065) conserved hypothetical protein [Thermoplasma
           acidophilum]
           Length = 362
           
 Score = 90.9 bits (222), Expect = 2e-17
 Identities = 82/373 (21%), Positives = 179/373 (47%), Gaps = 16/373 (4%)

Query: 4   IQVQEVMTDRYAKIDINAPLSEAIGIIEKEDPDLILVFDDNVYKGVLT-QDLIIRSHLKW 62
           ++V E+MT     + I+   S+ +  + +     + V D + Y G++T  DL+ +  ++ 
Sbjct: 1   MKVSELMTTDPITVSIDDTFSKVMSKMNETGIHQLPVMDGDRYAGMITYSDLLKKRSIQ- 59

Query: 63  DPTKAKVRDVYKPAPVVKPTDDLSHAAKLLLETDLRSLPVGENKAEILGVISDMALLERV 122
              K+K+ +     P +   DD+  A +L+ +T L +LPV + K +++G+IS   +++ +
Sbjct: 60  --VKSKISNYTISTPTLNADDDVLEAVRLIKDTGLSALPVFQ-KGKLVGIISRTDIIKNL 116

Query: 123 VA-EEFGKRKVEEFMTKDVITLGPDDTVAKALATMRDHGISRIPVVDEEGKLEGLVTLHD 181
               +    ++ + M+ D I +  DD + +A  +MR      IPV   + KL G++ L+ 
Sbjct: 117 PQIVDVRDVRIFQIMSSDPIYVYEDDDIEEAFDSMRMLNEVEIPVASRDEKLSGIIRLNS 176

Query: 182 LIIRFIKPRFKAQYGELAGEKIPPFSMKLREAMIKGVITIMPEATIREAVSTMKDNNIDG 241
           ++    + + K +YG   GEK  P  +K + +++   +++   A I EAV  M   ++  
Sbjct: 177 ILNILYRQKEKIKYGGY-GEK-EPVEIKCK-SLMDPPVSVDRYAGIDEAVKLMMQYSLH- 232

Query: 242 LVVVDENNKVVGILTVKDLLLPISRMVEKEARFYLQLGGDASALSEFTRERIINDIKRFV 301
           ++ V ++ K+VGI+   DL+  I    E +    +++ G      E   +      +RF+
Sbjct: 233 IMPVTDSGKIVGIVDFSDLINMIK--TESKEGILIEISG-LDVYDEDLYDIAFELSERFL 289

Query: 302 DGYADLLG-NEGIIYLYIRRFNEKFRGVHLYQARMRVVTDRGVFIARGETWGAIQAVHDA 360
           D ++ +   ++G + +++ ++  K +G   Y  R R+       +  G  W   + + + 
Sbjct: 290 DKFSKMTDVSQGKLLIHVMKY--KTQGSTKYSIRTRISAPPLFLVQNGSGWNFAEVLGEI 347

Query: 361 IRAIERQLLQKAE 373
               E ++ +  E
Sbjct: 348 FDRYEERIKKMKE 360


>sp|Q59011|IMDH_METJA INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (IMP DEHYDROGENASE) (IMPDH)
           (IMPD) >gi|2117504|pir||G64501 IMP dehydrogenase (EC
           1.1.1.205) - Methanococcus jannaschii
           >gi|1592337|gb|AAB99638.1| (U67602)
           inosine-5'-monophosphate dehydrogenase, (guaB)
           [Methanococcus jannaschii]
           Length = 496
           
 Score = 89.7 bits (219), Expect = 5e-17
 Identities = 51/152 (33%), Positives = 84/152 (54%), Gaps = 18/152 (11%)

Query: 110 LGVISDMALLERVVAEEFGKRKVEEFMTKDVITLGPDDTVAKALATMRDHGISRIPVVDE 169
           LGVI     +E  V +    +K +E + KDVIT+ PDDTV +A+  M  + IS +PVVD 
Sbjct: 70  LGVIHRNMSIEEQVHQVQAVKKADEVVIKDVITVSPDDTVGEAINVMETYSISGLPVVDN 129

Query: 170 EGKLEGLVTLHDLIIRFIKPRFKAQYGELAGEKIPPFSMKLREAMIKGVITIMPEATIRE 229
           E KL G++T  D  ++ I+ + K                K+++ M K V+    +    E
Sbjct: 130 EDKLVGIITHRD--VKAIEDKTK----------------KVKDVMTKDVVCAKEDVEEEE 171

Query: 230 AVSTMKDNNIDGLVVVDENNKVVGILTVKDLL 261
           A+  M  N ++ L +VD+ N+++GI+T++D+L
Sbjct: 172 ALELMYANRVERLPIVDDENRLIGIITLRDIL 203


>gb|AAK42850.1| Conserved hypothetical protein [Sulfolobus solfataricus]
           Length = 250
           
 Score = 88.2 bits (215), Expect = 2e-16
 Identities = 62/242 (25%), Positives = 125/242 (51%), Gaps = 21/242 (8%)

Query: 23  LSEAIGIIEKEDPDLILVFDDNVYKGVLTQDLIIRSHLKWDPT--KAKVRDVY-KPAPVV 79
           L EAI I+       I+V  +    G+++   ++ S  ++       KV+D+  K   +V
Sbjct: 20  LKEAIDILSNNPSGRIVVLKEEKPIGIVSTRDVVASFSEYGTNIYDLKVKDIMSKDLVIV 79

Query: 80  KPTDDLSHAAKLLLETDLRSLPVGENKAEILGVISDMALLERVVAEEFGKRKVEEFMTKD 139
            P DD++H  +++L  ++  +PV +N   I+G+ ++  +L+ + +  F    V+  M+ +
Sbjct: 80  SPNDDVNHVVRIMLMNNIGGIPVVDNNV-IVGIFTEREILKLIASSMFSGL-VDSVMSSN 137

Query: 140 VITLGPDDTVAKALATMRDHGISRIPVVDEEGKLEGLVTLHDLIIRFIKPRFKAQYGELA 199
           +I++G ++T+  A   M  + + R+PV  ++ +L G++T  D++      ++ A+   + 
Sbjct: 138 IISIGEENTIMDAAKLMVMNNVRRLPVFSKDNRLVGIITAADIV------KYLAKNKNIG 191

Query: 200 GEKIPPFSMKLREAMIKGVITIMPEATIREAVSTMKDNNIDGLVVVDENNKVVGILTVKD 259
                    K+ +A  K  ITI    +I  A   M +  I G ++V EN K+VGI+T +D
Sbjct: 192 ---------KVLDAGTKNPITINRYYSILNAAKLMIEKRI-GTLLVMENQKLVGIVTERD 241

Query: 260 LL 261
           L+
Sbjct: 242 LM 243


>sp|O58045|IMDH_PYRHO INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (IMP DEHYDROGENASE) (IMPDH)
           (IMPD) >gi|7427688|pir||E71456 IMP dehydrogenase (EC
           1.1.1.205) - Pyrococcus horikoshii
           >gi|3256697|dbj|BAA29380.1| (AP000001) 486aa long
           hypothetical inosine-5'-monophosphate dehydrogenase
           [Pyrococcus horikoshii]
           Length = 486
           
 Score = 85.8 bits (209), Expect = 8e-16
 Identities = 68/196 (34%), Positives = 101/196 (50%), Gaps = 29/196 (14%)

Query: 110 LGVISDMALLERVVAEEFGKRKVEEFMTKDVITLGPDDTVAKALATMRDHGISRIPVVDE 169
           LGVI     +E  V +    ++ E  + +DVIT+ PD+TV  AL  M  HGI  +PVV++
Sbjct: 73  LGVIHRNMGIEEQVEQVKRVKRAERLIVEDVITIAPDETVDFALFLMEKHGIDGLPVVED 132

Query: 170 EGKLEGLVTLHDLIIRFIKPRFKAQYGELAGEKIPPFSMKLREAMIKGVITIMPEATIRE 229
           E K+ G++T  D+          A+ G+L           ++E M K VIT+     + E
Sbjct: 133 E-KVVGIITKKDIA---------AREGKL-----------VKELMTKEVITVPESIEVEE 171

Query: 230 AVSTMKDNNIDGLVVVDENNKVVGILTVKDLLLPISRMVEKEARFYLQLGGD---ASALS 286
           A+  M +N ID L VVDE  K+VG++T+ DL   ++R   K A       G+   A+A+S
Sbjct: 172 ALKIMIENRIDRLPVVDERGKLVGLITMSDL---VARKKYKNA--VRDENGELLVAAAVS 226

Query: 287 EFTRERIINDIKRFVD 302
            F  +R I   K  VD
Sbjct: 227 PFDIKRAIELDKAGVD 242


 Score = 72.6 bits (175), Expect = 7e-12
 Identities = 73/264 (27%), Positives = 132/264 (49%), Gaps = 21/264 (7%)

Query: 8   EVMTDRYAKIDINAP-LSEAIGIIEKEDPDLILVFDDNVYKGVLTQDLIIRSHLKW-DPT 65
           +V T     + +N P LS A+  + + +  + +  +  +  GV+ +++ I   ++     
Sbjct: 35  DVSTRITPNVKLNIPILSAAMDTVTEWEMAVAMAREGGL--GVIHRNMGIEEQVEQVKRV 92

Query: 66  KAKVRDVYKPAPVVKPTDDLSHAAKLLLETDLRSLPVGENKAEILGVISDMALLERVVAE 125
           K   R + +    + P + +  A  L+ +  +  LPV E++ +++G+I+     ++ +A 
Sbjct: 93  KRAERLIVEDVITIAPDETVDFALFLMEKHGIDGLPVVEDE-KVVGIIT-----KKDIAA 146

Query: 126 EFGKRKVEEFMTKDVITLGPDDTVAKALATMRDHGISRIPVVDEEGKLEGLVTLHDLIIR 185
             GK  V+E MTK+VIT+     V +AL  M ++ I R+PVVDE GKL GL+T+ DL+ R
Sbjct: 147 REGKL-VKELMTKEVITVPESIEVEEALKIMIENRIDRLPVVDERGKLVGLITMSDLVAR 205

Query: 186 -FIKPRFKAQYGE-LAGEKIPPFSMK----LREAMIKGVITIMPEATIREAVSTMKD--N 237
              K   + + GE L    + PF +K    L +A +  ++     A   +A+ +MK+   
Sbjct: 206 KKYKNAVRDENGELLVAAAVSPFDIKRAIELDKAGVDVIVVDTAHAHNLKAIKSMKEMRQ 265

Query: 238 NIDGLVVVDE--NNKVVGILTVKD 259
            +D   +V    N K V  LT  D
Sbjct: 266 KVDADFIVGNIANPKAVDDLTFAD 289


>sp|P42851|IMDH_PYRFU INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (IMP DEHYDROGENASE) (IMPDH)
           (IMPD) >gi|2117506|pir||JC4998 IMP dehydrogenase (EC
           1.1.1.205) - Pyrococcus furiosus
           >gi|595287|gb|AAC44532.1| (U08814) IMP dehydrogenase
           [Pyrococcus furiosus]
           Length = 485
           
 Score = 84.3 bits (205), Expect = 2e-15
 Identities = 50/152 (32%), Positives = 81/152 (52%), Gaps = 21/152 (13%)

Query: 110 LGVISDMALLERVVAEEFGKRKVEEFMTKDVITLGPDDTVAKALATMRDHGISRIPVVDE 169
           LGVI     +E  V +    ++ E F+ +DVIT+ PD+T+  AL  M  HGI  +PVV+E
Sbjct: 73  LGVIHRNMSIEEQVEQVKRVKRAERFIVEDVITIAPDETIDYALFLMEKHGIDGLPVVEE 132

Query: 170 EGKLEGLVTLHDLIIRFIKPRFKAQYGELAGEKIPPFSMKLREAMIKGVITIMPEATIRE 229
           + ++ G++T  D+  R                        ++E M + VIT+     + E
Sbjct: 133 D-RVVGIITKKDIAARE--------------------GRTVKELMTREVITVPESVDVEE 171

Query: 230 AVSTMKDNNIDGLVVVDENNKVVGILTVKDLL 261
           A+  M +N ID L VV+E+ K+VG++T+ DL+
Sbjct: 172 ALKIMMENRIDRLPVVNEDGKLVGLITMSDLV 203


 Score = 71.0 bits (171), Expect = 2e-11
 Identities = 70/264 (26%), Positives = 129/264 (48%), Gaps = 21/264 (7%)

Query: 8   EVMTDRYAKIDINAP-LSEAIGIIEKEDPDLILVFDDNVYKGVLTQDLIIRSHLKW-DPT 65
           +V T     + +N P LS A+  + + +  + +  +  +  GV+ +++ I   ++     
Sbjct: 35  DVSTQITPNVKLNIPILSAAMDTVTEWEMAVAMAREGGL--GVIHRNMSIEEQVEQVKRV 92

Query: 66  KAKVRDVYKPAPVVKPTDDLSHAAKLLLETDLRSLPVGENKAEILGVISDMALLERVVAE 125
           K   R + +    + P + + +A  L+ +  +  LPV E    ++G+I+     ++ +A 
Sbjct: 93  KRAERFIVEDVITIAPDETIDYALFLMEKHGIDGLPVVEED-RVVGIIT-----KKDIAA 146

Query: 126 EFGKRKVEEFMTKDVITLGPDDTVAKALATMRDHGISRIPVVDEEGKLEGLVTLHDLIIR 185
             G R V+E MT++VIT+     V +AL  M ++ I R+PVV+E+GKL GL+T+ DL+ R
Sbjct: 147 REG-RTVKELMTREVITVPESVDVEEALKIMMENRIDRLPVVNEDGKLVGLITMSDLVAR 205

Query: 186 -FIKPRFKAQYGE-LAGEKIPPFSMK----LREAMIKGVITIMPEATIREAVSTMKDN-- 237
              K   + + GE L    + PF ++    L  A +  ++     A   +A+  MK+   
Sbjct: 206 KKYKNAVRNEKGELLVAAAVSPFDLRRAIELDRAGVDVIVVDTAHAHNLKAIKAMKEMRQ 265

Query: 238 --NIDGLVVVDENNKVVGILTVKD 259
             + D +V    N K V  LT  D
Sbjct: 266 KVSADFIVGNIANPKAVDDLTFAD 289


>gb|AAK40395.1| Conserved hypothetical protein [Sulfolobus solfataricus]
           Length = 380
           
 Score = 83.1 bits (202), Expect = 5e-15
 Identities = 79/356 (22%), Positives = 168/356 (47%), Gaps = 19/356 (5%)

Query: 23  LSEAIGIIEKEDPDLILVFDDNVYKGVLT-QDLIIRSHLKWDPTKAKVRDVYKPAPVVKP 81
           LS+ I  +++     + V  D    G+++ +DL+ R        + K  ++  P+  V+ 
Sbjct: 20  LSDIISKMKENKMWTVPVIKDRKLIGLISYKDLLSRRV----SLETKAINIMSPSVTVQI 75

Query: 82  TDDLSHAAKLLLETDLRSLPVGENKAEILGVISDMALLERVV-AEEFGK-RKVEEFMTKD 139
            +D++        T  R +PV   K E +G+++  +LL  ++ A E  + R   E+MT  
Sbjct: 76  DEDINRLIAKFYTTKARVIPVINEKREFIGLVTRESLLSYLLKANEIPENRTAREYMTSP 135

Query: 140 VITLGPDDTVAKALATMRDHGISRIPVVDEEGKLEGLVTLHDLIIRFIKPRFKAQYGELA 199
             ++  +D++A+A   M    ISR+P   +E +L G+++  D++        + +   + 
Sbjct: 136 ATSIDENDSIARARWLMIRDNISRLPAT-KEYRLTGIISARDIVDALYSVSGRKRESIMK 194

Query: 200 GEKIPPFSMKLREAMIKGVITIMPEATIREAVSTMKDNNIDGLVVVDENNKVVGILTVKD 259
            E+    +M ++E M   VIT   + ++ + V  +    I G+ V+ E +++ G+++  D
Sbjct: 195 DEE-RVMAMPVKEIMKYPVITANGKDSLTDVVEKLLKFRISGMPVM-EGDRLSGVISGLD 252

Query: 260 LLLPISRMVEKEARFYLQLGGDASALSEFTRERIINDIKRFVDGYADLLGNEGIIYLYIR 319
           ++  ++  ++       ++  +  +  EF     I+DI   ++ Y   +     +  +  
Sbjct: 253 IIKAVAEKMQLSIPIEAKIPQELKSNLEFKAN--IDDI---LERYLSKIERLTEVINFKV 307

Query: 320 RFNEKFR----GVHLYQARMRVVTDRGVFIARGETWGAIQAVHDAIRAIERQLLQK 371
            F E+ R       LY A +RV T  G ++AR   W  + A+ +A+  IE ++L+K
Sbjct: 308 SFKEEMRSSTGNKKLYTAMVRVTTKIGDYVARDTDWEPVVALKNAVEKIEERILRK 363


>pir||D69030 MJ1225-related protein MTH1223 - Methanobacterium
           thermoautotrophicum (strain Delta H)
           >gi|2622334|gb|AAB85712.1| (AE000890)
           inosine-5'-monophosphate dehydrogenase related protein
           II [Methanobacterium thermoautotrophicum]
           Length = 281
           
 Score = 81.9 bits (199), Expect = 1e-14
 Identities = 76/280 (27%), Positives = 132/280 (47%), Gaps = 22/280 (7%)

Query: 1   MVGIQVQEVMTDRYAKIDINAPLSEAIGIIEKEDPDLILVFD-DNVYKGVLTQDLIIRSH 59
           MV + +  +MTD    +D    ++ A  ++ +     ++V D D    G++T+  I R  
Sbjct: 1   MVTVDIGSIMTDEVIVMDETQQVAYARNLMLRHGISRVVVVDADGKPVGIVTETDITRKL 60

Query: 60  LKWDPT-------KAKVRDVYKPAPV-VKPTDDLSHAAKLLLETDLRSLPVGENKAEILG 111
               P        K  +R V    PV V   D    AA+L+L  ++ SL V + + E+ G
Sbjct: 61  RVNGPDWRRRPIDKISIRRVMTENPVTVNVNDTPRDAAELMLRKNVGSLLVMDGE-ELAG 119

Query: 112 VISDMALLERVVAEEFGKRKVEEFMTKDVITLGPDDTVAKALATMRDHGISRIPVVDEEG 171
           +++   LL        G+ KV + MT+DV T+ P+ T++  +  M ++ ISR+ VV + G
Sbjct: 120 IVTKKDLLRFFKDRCAGRWKVRDLMTEDVKTVTPNHTLSHVIGVMEENNISRV-VVTDNG 178

Query: 172 KLEGLVTLHDL-IIRFIKPR---------FKAQYGELAGEKIPPFSMKLREAMIKGVITI 221
            +EG++T  +L    F  P          F ++  E          +   + M + VI +
Sbjct: 179 AVEGIITSENLSFATFEDPERGIPVERVYFISRTSEEKKRVRTIAMLTAGDIMTEDVIKV 238

Query: 222 MPEATIREAVSTMKDNNIDGLVVVDENNKVVGILTVKDLL 261
            P      A + M +N I GL VV E++++VGI+T  D++
Sbjct: 239 EPSVDASSAAAMMLENGISGLPVV-EDDELVGIITKTDII 277


>pir||E75015 IMP dehydrogenase (EC 1.1.1.205) PAB1250 - Pyrococcus abyssi
           (strain Orsay) >gi|5459077|emb|CAB50563.1| (AJ248288)
           INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (EC 1.1.1.205)
           (IMP DEHYDROGENASE) (IMPDH) (IMPD). [Pyrococcus abyssi]
           Length = 485
           
 Score = 80.4 bits (195), Expect = 3e-14
 Identities = 51/152 (33%), Positives = 82/152 (53%), Gaps = 21/152 (13%)

Query: 110 LGVISDMALLERVVAEEFGKRKVEEFMTKDVITLGPDDTVAKALATMRDHGISRIPVVDE 169
           LGVI     +E  V +    +K E F+ +DVIT+ P++TV  AL  M  H I  +PVV+ 
Sbjct: 73  LGVIHRNMSIEEQVEQVKRVKKAERFIVEDVITISPEETVDFALFLMEKHDIDGLPVVEN 132

Query: 170 EGKLEGLVTLHDLIIRFIKPRFKAQYGELAGEKIPPFSMKLREAMIKGVITIMPEATIRE 229
           E K+ G+++  D+          A+ G+L           ++E M K VIT+     + E
Sbjct: 133 E-KVVGIISKKDIA---------AREGKL-----------VKELMTKDVITVPENIEVEE 171

Query: 230 AVSTMKDNNIDGLVVVDENNKVVGILTVKDLL 261
           A+  M +N ID L VVD+  +++G++T+ DL+
Sbjct: 172 ALKIMIENRIDRLPVVDKEGRLIGLITMSDLV 203


 Score = 78.0 bits (189), Expect = 2e-13
 Identities = 75/264 (28%), Positives = 133/264 (49%), Gaps = 21/264 (7%)

Query: 8   EVMTDRYAKIDINAP-LSEAIGIIEKEDPDLILVFDDNVYKGVLTQDLIIRSHLKW-DPT 65
           +V T     + +N P LS A+  + + +  + +  +  +  GV+ +++ I   ++     
Sbjct: 35  DVSTQITPNVKLNIPILSAAMDTVTEWEMAVAMAREGGL--GVIHRNMSIEEQVEQVKRV 92

Query: 66  KAKVRDVYKPAPVVKPTDDLSHAAKLLLETDLRSLPVGENKAEILGVISDMALLERVVAE 125
           K   R + +    + P + +  A  L+ + D+  LPV EN+ +++G+IS     ++ +A 
Sbjct: 93  KKAERFIVEDVITISPEETVDFALFLMEKHDIDGLPVVENE-KVVGIIS-----KKDIAA 146

Query: 126 EFGKRKVEEFMTKDVITLGPDDTVAKALATMRDHGISRIPVVDEEGKLEGLVTLHDLIIR 185
             GK  V+E MTKDVIT+  +  V +AL  M ++ I R+PVVD+EG+L GL+T+ DL+ R
Sbjct: 147 REGKL-VKELMTKDVITVPENIEVEEALKIMIENRIDRLPVVDKEGRLIGLITMSDLVAR 205

Query: 186 -FIKPRFKAQYGE-LAGEKIPPF----SMKLREAMIKGVITIMPEATIREAVSTMKD--N 237
              K   + + GE L    + PF    +++L  A    ++     A   +A+  MK+   
Sbjct: 206 KKYKNAVRDENGELLVAAAVSPFDIRRAIELDRAGADVIVVDTAHAHNLKAIKAMKEMRQ 265

Query: 238 NIDGLVVVDE--NNKVVGILTVKD 259
            +D   +V    N K V  LT  D
Sbjct: 266 KVDADFIVGNIANPKAVDDLTFAD 289


>pir||F72780 hypothetical protein APE0231 - Aeropyrum pernix (strain K1)
           >gi|5103623|dbj|BAA79144.1| (AP000058) 287aa long
           hypothetical protein [Aeropyrum pernix]
           Length = 287
           
 Score = 79.6 bits (193), Expect = 6e-14
 Identities = 53/161 (32%), Positives = 85/161 (51%), Gaps = 22/161 (13%)

Query: 131 KVEEFMTKDVITLGPDDTVAKALATMRDHGISRIPVVDEEGKLEGLVTLHDLIIRFIKPR 190
           +V  +MT+DV T+ PDDT+A A   M  H ISR+PVV E  KL G++T+ D+    ++ +
Sbjct: 4   RVVSYMTRDVYTVSPDDTLAHARKLMLTHDISRLPVV-EGSKLRGIITITDIADALVR-K 61

Query: 191 FKAQYGELAGEKIPPFSMKLREAMIKGVITIMPEATIREAVSTMKDNNIDGLVVVDENNK 250
           + ++         P  S+ +RE M + V+TI    +++ A S M  +NI G+ VV  +  
Sbjct: 62  YPSR---------PANSIYVREVMARDVVTIEGTKSVKTAASLMLKHNIGGVPVVAPDGT 112

Query: 251 VVGILTVKDLLLPISRMVEKEARFYLQLGGDASALSEFTRE 291
           + GI+T  DL            R+Y +     + + EF RE
Sbjct: 113 LEGIITRTDL-----------TRYYSEKMKGVNLVKEFMRE 142


 Score = 71.0 bits (171), Expect = 2e-11
 Identities = 61/195 (31%), Positives = 95/195 (48%), Gaps = 24/195 (12%)

Query: 70  RDVYKPAPVVKPTDDLSHAAKLLLETDLRSLPVGE-NKAEILGVISDMA--LLERVVAEE 126
           RDVY     V P D L+HA KL+L  D+  LPV E +K   +  I+D+A  L+ +  +  
Sbjct: 11  RDVY----TVSPDDTLAHARKLMLTHDISRLPVVEGSKLRGIITITDIADALVRKYPSRP 66

Query: 127 FGKRKVEEFMTKDVITLGPDDTVAKALATMRDHGISRIPVVDEEGKLEGLVTLHDLIIRF 186
                V E M +DV+T+    +V  A + M  H I  +PVV  +G LEG++T  DL  R+
Sbjct: 67  ANSIYVREVMARDVVTIEGTKSVKTAASLMLKHNIGGVPVVAPDGTLEGIITRTDL-TRY 125

Query: 187 IKPRFKAQYGELAGEKIPPFSMKL-REAMIKGVITIMPEATIREAVSTMKDNNIDGLVVV 245
              + K     L  E +     K  RE  I  V+ +M             + +  G V++
Sbjct: 126 YSEKMKGV--NLVKEFMREIYAKARREHSIFYVLKLM-------------EIDATGKVLI 170

Query: 246 DENNKVVGILTVKDL 260
            +  K+VG++T +D+
Sbjct: 171 LDGGKLVGVITKRDI 185


>sp|Q58332|Y922_METJA HYPOTHETICAL PROTEIN MJ0922 >gi|2127741|pir||B64415 yhcV homolog -
           Methanococcus jannaschii >gi|1591595|gb|AAB98926.1|
           (U67535) conserved hypothetical protein [Methanococcus
           jannaschii]
           Length = 138
           
 Score = 78.8 bits (191), Expect = 1e-13
 Identities = 49/143 (34%), Positives = 81/143 (56%), Gaps = 18/143 (12%)

Query: 131 KVEEFMTKDVITLGPDDTVAKALATMRDHGISRIPVVDEEGKLEGLVTLHDLIIRFIKPR 190
           KV++ MTK+VIT    + V +A   M  + IS +PV+D+E K+ G+VT  D+    I+ +
Sbjct: 9   KVKDVMTKNVITAKRHEGVVEAFEKMLKYKISSLPVIDDENKVIGIVTTTDIGYNLIRDK 68

Query: 191 FKAQYGELAGEKIPPFSMKLREAMIKGVITIMPEATIREAVSTM-----KDNNIDGLVVV 245
           +  +               + + M K VITI  +A+I EA+  M     K+  I+ L VV
Sbjct: 69  YTLE-------------TTIGDVMTKDVITIHEDASILEAIKKMDISGKKEEIINQLPVV 115

Query: 246 DENNKVVGILTVKDLLLPISRMV 268
           D+NNK+VGI++  D++  IS+++
Sbjct: 116 DKNNKLVGIISDGDIIRTISKII 138


>sp|Q58629|YC32_METJA HYPOTHETICAL PROTEIN MJ1232 >gi|2128738|pir||G64453 conserved
           hypothetical protein MJ1232 - Methanococcus jannaschii
           >gi|1591864|gb|AAB99237.1| (U67564) conserved
           hypothetical protein [Methanococcus jannaschii]
           Length = 296
           
 Score = 77.6 bits (188), Expect = 2e-13
 Identities = 61/202 (30%), Positives = 96/202 (47%), Gaps = 37/202 (18%)

Query: 83  DDLSH----AAKLLLETDLRSLPVGE---------NKAEILGVISDMALLERVV------ 123
           D +SH    ++K+ +E D +   +G+         NK  I G I     + R++      
Sbjct: 104 DTVSHEKCCSSKIHIEGDTKHFNIGDIIRVGPTYHNKIIINGKIIGRDDIHRILLIDVLG 163

Query: 124 AEEFGKRKVEEFMTKDVITLGPDDTVAKALATMRDHGISRIPVVDEEGKLEGLVTLHDLI 183
                  KV +   K+V T+ P+ T+ +      +  IS  PVVD + KL G+++LHD+ 
Sbjct: 164 VSSIPNIKVGDVGIKEVWTINPNCTLRETAKLFAEKYISGAPVVDND-KLVGVISLHDI- 221

Query: 184 IRFIKPRFKAQYGELAGEKIPPFSMKLREAMIKGVITIMPEATIREAVSTMKDNNIDGLV 243
                            E I     K++E M + VITI  +  I +A+  M  NN+  LV
Sbjct: 222 ----------------AENIDNIDKKVKEVMRRDVITIHKDEKIYDALKIMNKNNVGRLV 265

Query: 244 VVDENNKVVGILTVKDLLLPIS 265
           +VD+NNK+VGI+T  D+L  IS
Sbjct: 266 IVDDNNKIVGIITRTDILKIIS 287


>pir||D69035 MJ1232 protein homolog MTH126 - Methanobacterium
           thermoautotrophicum (strain Delta H)
           >gi|2621166|gb|AAB84632.1| (AE000802)
           inosine-5'-monophosphate dehydrogenase related protein
           VII [Methanobacterium thermoautotrophicum]
           Length = 302
           
 Score = 77.6 bits (188), Expect = 2e-13
 Identities = 53/178 (29%), Positives = 88/178 (48%), Gaps = 22/178 (12%)

Query: 90  KLLLETDLRSLPVGENKAEILGVI------SDMALLERVVAEEFGKRKVEEFMTKDVITL 143
           KL L   +R  P   NK  + GV+       ++ LL+        K+ V E  T+D++TL
Sbjct: 134 KLDLGDRVRIGPTPVNKLVVDGVVVGRDDMDNIILLDTTAIRSIPKKTVAEVATRDLVTL 193

Query: 144 GPDDTVAKALATMRDHGISRIPVVDEEGKLEGLVTLHDLIIRFIKPRFKAQYGELAGEKI 203
            PD TV +A A +   GI   P+V+++ +++G+VTL D+                AG + 
Sbjct: 194 APDITVKEAAARLSSLGIEGAPIVEDD-EVKGIVTLSDITASIA-----------AGTEF 241

Query: 204 PPFSMKLREAMIKGVITIMPEATIREAVSTMKDNNIDGLVVVDENNKVVGILTVKDLL 261
               M++ + M K +IT+  +  I +A+  M  +NI  L+V D   +  GI+T  D+L
Sbjct: 242 ----MQVSDIMSKNIITVKQDTMIADAIEVMNKHNIGRLIVTDSEGRPTGIITRTDIL 295


>pir||C69030 MJ1225 protein homolog MTH1222 - Methanobacterium
           thermoautotrophicum (strain Delta H)
           >gi|2622333|gb|AAB85711.1| (AE000890)
           inosine-5'-monophosphate dehydrogenase related protein I
           [Methanobacterium thermoautotrophicum]
           Length = 275
           
 Score = 77.6 bits (188), Expect = 2e-13
 Identities = 69/275 (25%), Positives = 135/275 (49%), Gaps = 24/275 (8%)

Query: 1   MVGIQVQEVMTDRYAKIDINAPLSEAIGIIEKEDPDLILVFDDNV-----YKGVLTQ-DL 54
           M  + ++ +M++    ID +  + +A+ +++K +   +LV + N        G++T+ D+
Sbjct: 1   MESMIIKNIMSEDPVCIDKDQNICDALRLMDKRNVSRLLVINTNSDHERELVGIVTEKDI 60

Query: 55  IIR----SHLKWDPTKAKVRDVYKPAPVV-KPTDDLSHAAKLLLETDLRSLPVGENKAEI 109
            ++     +    P+   V  V  P  +  +P  D  +AA ++LE ++ SLPV  +  EI
Sbjct: 61  ALKLGSSRYGNMAPSHFHVSTVMTPELITAEPDMDAGNAASVMLENNIGSLPVLHD-GEI 119

Query: 110 LGVISDMALLERVVAEEFGKRKVEEFMTKDVITLGPDDTVAKALATMRDHGISRIPVVDE 169
           +G+++   LL+      + K    + M+ ++IT+ P + V  A   M D GI R+ V+ E
Sbjct: 120 MGIVTKSDLLDICRGRAYEKYTAADVMSTEMITVSPAERVVHARRIMIDAGIGRLLVM-E 178

Query: 170 EGKLEGLVTLHDLIIRFIKPRFKAQYGELAGEKIPPFSMK---LREAMIKGVITIMPEAT 226
           E +L G++T  D+       R    + +L  ++  P  ++   + + M + V TI  E  
Sbjct: 179 EDELAGILTARDM------TRAVINFRKLVPDRHKPSRIRNLLVEDIMKQNVRTIEEETP 232

Query: 227 IREAVSTMKDNNIDGLVVVDENNKVVGILTVKDLL 261
           + E  S M +    G  V+ +  +V GI+T  D+L
Sbjct: 233 VTEVASLMLETGYGGFPVIKQ--EVEGIVTKTDIL 265


>sp|P15889|YR33_THEPE HYPOTHETICAL 33.4 KD PROTEIN IN RIBOSOMAL RNA OPERON
           >gi|81092|pir||S08244 conserved hypothetical protein
           MJ1225 homolog - Thermofilum pendens
           >gi|48226|emb|CAA32944.1| (X14835) open reading frame 1
           (300 AA) [Thermofilum pendens]
           Length = 300
           
 Score = 76.5 bits (185), Expect = 5e-13
 Identities = 61/227 (26%), Positives = 112/227 (48%), Gaps = 20/227 (8%)

Query: 41  FDDNVYKGVLTQDLIIRSHLKWDPTKAKVRDVYKPAPVVKPTDDLSHAAKLLLETDLRSL 100
           F+ +VYK +    +     LK+DP            P V    DL    +L++E  + +L
Sbjct: 73  FNGDVYKALEQTGV---EFLKYDP------------PYVYTRSDLREVIELMVERGIGAL 117

Query: 101 PVGENKAEILGVISDMALLERVVAEEFGKRKVEEFMTKDVITLGPDDTVAKALATMRDHG 160
            V +    ++G++S+  ++  ++A      KV+E MT +V+ L P D++ + +  M +  
Sbjct: 118 AVVDEDLRVVGIVSERHVIS-LLANVETHVKVKEIMTSEVVYLSPMDSLFEGMRVMSERR 176

Query: 161 ISRIPVVDEEGKLEGLVTLHDLIIRFIKPRFKAQYGELAGEKIPPFSMKLREAMIKGVIT 220
           I R+P+V  E +L G+VT+ D++    +    A+  E  G +   +   L     K V+ 
Sbjct: 177 IRRLPLVSGE-ELRGIVTIKDVLSYVSREDVLARLKE--GSRSAVYDTPLVYISSKPVLA 233

Query: 221 IMPEATIREAVSTMKDNNIDGLVVVDENNKVVGILTVKDLLLPISRM 267
           +  +  +  AVS MK + I G +VV  + K  GI+T +D+L  + R+
Sbjct: 234 VEDDVDVGLAVSLMKKHGI-GALVVTHDGKPRGIVTERDVLTRLPRV 279


>pir||F69185 yhcV homolog MTH644 - Methanobacterium thermoautotrophicum  (strain
           Delta H) >gi|2621725|gb|AAB85149.1| (AE000844) conserved
           protein [Methanobacterium thermoautotrophicum]
           Length = 157
           
 Score = 76.1 bits (184), Expect = 6e-13
 Identities = 46/150 (30%), Positives = 80/150 (52%), Gaps = 19/150 (12%)

Query: 131 KVEEFMTKDVITLGPDDTVAKALATMRDHGISRIPVVDEEGKLEGLVTLHDLI------- 183
           +V++ M  DVIT+    ++  A   +R++ IS  PVVDE+GKL G+++  D++       
Sbjct: 3   RVKDAMQSDVITVKRTSSIHDAARVLRENRISGAPVVDEDGKLVGIISEGDIMRLIEVHS 62

Query: 184 --IRFIKP----------RFKAQYGELAGEKIPPFSMKLREAMIKGVITIMPEATIREAV 231
             +  I P          R K +Y E+A        M++ E M   V+T+ P A++ +A 
Sbjct: 63  PSLNLIMPSPLDLLELPLRMKHEYDEIARGIRKAAVMRVEEIMTPKVVTVPPHASVSDAA 122

Query: 232 STMKDNNIDGLVVVDENNKVVGILTVKDLL 261
             M+ ++I  L V+DEN ++ GI+T  D++
Sbjct: 123 ELMERHDIKRLPVIDENGRLAGIITRGDII 152


>sp|P50100|IMDH_METKA PUTATIVE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (IMP DEHYDROGENASE)
           (IMPDH) (IMPD) (ORFX) >gi|1002715|gb|AAA92086.1|
           (U31567) similar to the inosine monophosphate
           dehydrogenase from Pyrococcus furiosus (SwissProt
           Accession Number P42851);  orfX protein;  Method:
           conceptual translation supplied by author [Methanopyrus
           kandleri]
           Length = 172
           
 Score = 75.3 bits (182), Expect = 1e-12
 Identities = 43/130 (33%), Positives = 72/130 (55%), Gaps = 12/130 (9%)

Query: 132 VEEFMTKDVITLGPDDTVAKALATMRDHGISRIPVVDEEGKLEGLVTLHDLIIRFIKPRF 191
           V E   +DVIT  P +T  +    MR+HGI  + +V+E+ +  G++T  DL+I+ +    
Sbjct: 6   VGEVARRDVITGSPTETAVEIAYKMREHGIGSVVIVNEKDEPIGIITERDLVIKVVSQ-- 63

Query: 192 KAQYGELAGEKIPPFSMKLREAMIKGVITIMPEATIREAVSTMKDNNIDGLVVVDENNKV 251
                   G+   P  +  R+ M + VIT+  +  + EAV  M D  I  L +VD+N K+
Sbjct: 64  --------GKN--PDEVIARDIMSQPVITVEEDMEVNEAVKLMVDKGIRRLPIVDDNGKL 113

Query: 252 VGILTVKDLL 261
           +GI+T++D+L
Sbjct: 114 IGIVTMQDIL 123


>gi|11498454 conserved hypothetical protein [Archaeoglobus fulgidus]
           >gi|7429331|pir||H69355 conserved hypothetical protein
           MJ1225 homolog - Archaeoglobus fulgidus
           >gi|2649753|gb|AAB90389.1| (AE001045) conserved
           hypothetical protein [Archaeoglobus fulgidus]
           Length = 284
           
 Score = 74.9 bits (181), Expect = 1e-12
 Identities = 51/188 (27%), Positives = 97/188 (51%), Gaps = 7/188 (3%)

Query: 79  VKPTDDLSHAAKLLLETDLRSLPVGENKAEILGVISDMALLERVVAEEFGKRKVEEFMTK 138
           V  +D L  A + + E ++   P+      ++G+I++  +L+ + A         ++MT 
Sbjct: 92  VNESDSLEEAVETMFEKNVGGCPIVNKDDVVVGIITERDILKYLGANRSIDGVASDYMTS 151

Query: 139 DVITLGPDDTVAKALATMRDHGISRIPVVDEEGKLEGLVTLHDLIIRF-IKPRFK-AQYG 196
            VITL P D++ +A+ TM +  + RIP++D +G L GL+T+ +++  F     F+    G
Sbjct: 152 SVITLRPKDSIERAMRTMIEKKLRRIPIID-DGILVGLITVREILRYFGTGEAFRMLTSG 210

Query: 197 ELAGEKIPPFSMKLRE---AMIKGVITIMPEATIREAVSTMKDNNIDGLVVVDENNKVVG 253
            +      P S  L      + K ++T     +I + VS+M +    G+ ++ EN K+ G
Sbjct: 211 NIKDAIDKPISTILANDELLVYKDILTFPRNISISQLVSSMLEKGY-GVALIVENGKLEG 269

Query: 254 ILTVKDLL 261
           I+T +DL+
Sbjct: 270 IITERDLI 277


 Score = 72.2 bits (174), Expect = 1e-11
 Identities = 48/147 (32%), Positives = 76/147 (51%), Gaps = 4/147 (2%)

Query: 134 EFMTKDVITLGPDDTVAKALATMRDHGISRIPVVDEEGK-LEGLVTLHDLIIRFIK-PRF 191
           E  TKDV TL P  T+  AL  M      RIP+ D   K LEG+++  D +  F   P+F
Sbjct: 3   EIATKDVFTLPPTSTLMNALKMMLRRNFRRIPIADPGTKRLEGIISATDFVNIFGGGPKF 62

Query: 192 KAQYGELAGEKIPPFSMKLREAMIKGVITIMPEATIREAVSTMKDNNIDGLVVVDENNKV 251
               G   G      +  +   M + V+T+    ++ EAV TM + N+ G  +V++++ V
Sbjct: 63  GLIKGRYGGNLSAAVNEVVETIMEREVVTVNESDSLEEAVETMFEKNVGGCPIVNKDDVV 122

Query: 252 VGILTVKDLL--LPISRMVEKEARFYL 276
           VGI+T +D+L  L  +R ++  A  Y+
Sbjct: 123 VGIITERDILKYLGANRSIDGVASDYM 149


>sp|Q58622|YC25_METJA HYPOTHETICAL PROTEIN MJ1225 >gi|2128050|pir||H64452 conserved
           hypothetical protein MJ1225 - Methanococcus jannaschii
           >gi|1591856|gb|AAB99228.1| (U67563) conserved
           hypothetical protein [Methanococcus jannaschii]
           Length = 280
           
 Score = 74.5 bits (180), Expect = 2e-12
 Identities = 60/244 (24%), Positives = 122/244 (49%), Gaps = 9/244 (3%)

Query: 19  INAPLSEAIGIIEKEDPDLILVFDDNVYKGVLTQDLIIRSHLKWDPTKAKVRDVYKPAPV 78
           +NA  ++ +GII   D   I+ F     K  L ++   R+ L        VR++ +   +
Sbjct: 41  VNAGNNKVVGIITSMD---IVDFMGGGSKYNLIREKHERNFLA--AINEPVREIMEENVI 95

Query: 79  -VKPTDDLSHAAKLLLETDLRSLPVGENKAEILGVISDMALLERVVAEEFGKRKVEEFMT 137
            +K   D+  A +  L  ++   P+  ++ +++ +I++  ++  ++ +      +++++T
Sbjct: 96  TLKENADIDEAIETFLTKNVGGAPIVNDENQLISLITERDVIRALLDKIDENEVIDDYIT 155

Query: 138 KDVITLGPDDTVAKALATMRDHGISRIPVVDEEGKLEGLVTLHDLIIRFIKPRFKAQYGE 197
           +DVI   P + +     TM  +G  R+PVV  EG+L G++T  D  I+ +   +   + +
Sbjct: 156 RDVIVATPGERLKDVARTMVRNGFRRLPVV-SEGRLVGIITSTD-FIKLLGSDWAFNHMQ 213

Query: 198 LAGEKIPPFSMKLREAMIKGVITIMPEATIREAVSTMKDNNIDGLVVVDENNKVVGILTV 257
             G      ++++ E M + VIT      +++    M  N+I  L VVDEN ++ GI+T 
Sbjct: 214 -TGNVREITNVRMEEIMKRDVITAKEGDKLKKIAEIMVTNDIGALPVVDENLRIKGIITE 272

Query: 258 KDLL 261
           KD+L
Sbjct: 273 KDVL 276


>pir||C72264 IMP dehydrogenase (EC 1.1.1.205) - Thermotoga maritima  (strain
           MSB8) >gi|4981907|gb|AAD36418.1|AE001789_3 (AE001789)
           inosine-5'-monophosphate dehydrogenase [Thermotoga
           maritima]
           Length = 482
           
 Score = 73.7 bits (178), Expect = 3e-12
 Identities = 54/175 (30%), Positives = 88/175 (49%), Gaps = 20/175 (11%)

Query: 130 RKVEEFMTKDVITLGPDDTVAKALATMRDHGISRIPVVDEEGKLEGLVTLHDLIIRFIKP 189
           +K E  +  D IT+ PD TV +A+  M ++ I  +PVVDEEG+L GL+T  D  +RF K 
Sbjct: 83  KKTENGIIYDPITVTPDMTVKEAIDLMAEYKIGGLPVVDEEGRLVGLLTNRD--VRFEK- 139

Query: 190 RFKAQYGELAGEKIPPFSMKLREAMI--KGVITIMPEATIREAVSTMKDNNIDGLVVVDE 247
                            S K+++ M   + +I   P+ ++ +A   +  + I+ L +V +
Sbjct: 140 ---------------NLSKKIKDLMTPREKLIVAPPDISLEKAKEILHQHRIEKLPLVSK 184

Query: 248 NNKVVGILTVKDLLLPISRMVEKEARFYLQLGGDASALSEFTRERIINDIKRFVD 302
           +NK+VG++T+KD++  I             L G A   S  T ER+   +K  VD
Sbjct: 185 DNKLVGLITIKDIMSVIEHPNAARDEKGRLLVGAAVGTSPETMERVEKLVKAGVD 239


>pir||C75148 hypothetical protein PAB2118 - Pyrococcus abyssi (strain Orsay)
           >gi|5457776|emb|CAB49266.1| (AJ248284) hypothetical
           protein [Pyrococcus abyssi]
           Length = 282
           
 Score = 73.0 bits (176), Expect = 6e-12
 Identities = 73/280 (26%), Positives = 125/280 (44%), Gaps = 28/280 (10%)

Query: 4   IQVQEVMTDRYAKIDINAPLSEAIGIIEKEDPDLILVFDDNVYKGVLTQDLIIRSHLKWD 63
           ++V+ +MT     I + A  + A+ I +K       V +    +G L   + I+  L   
Sbjct: 1   MKVKTIMTPNPVTITLPATRNYALDIFKKHKVRSFPVVNR---EGKLVGIISIKRVLTNP 57

Query: 64  PTKAKVRDVYKPAPVVKPTDDLSHAAKLLLETDLRSLPVGENKAEILGVISDMALLERVV 123
             +     V +  P VK  DDL  AA+L+LE D R + V +N+ + +G+++   ++ R +
Sbjct: 58  DEEQLAMLVKRDVPTVKENDDLKKAARLMLEHDYRRVVVVDNEGKPVGILTVGDIVRRYL 117

Query: 124 A--EEFGKRKVEEFMTKDVITLGPDDTVAKALATMRDHGISRIPVVDEEGKLEGLVTLHD 181
           A  E++ + ++E +  + V  +     +  AL  +       +PVVD+ G+L G++   D
Sbjct: 118 AKTEKYKEVEIEPYYQRHVSIVWKGTPLKAALKALLLSNAMALPVVDDNGELIGIIDETD 177

Query: 182 L-----IIRFIKPRFKAQYGE----------LAGEKIPPFSMKL-----REAMIKGVITI 221
           L     I+R +K    A   E          L  EK   F ++L      E M K VI  
Sbjct: 178 LLRDSEIVRIMKSTELAASSEEEWILESHPTLLFEK---FELQLPNKPVEEIMTKDVIVA 234

Query: 222 MPEATIREAVSTMKDNNIDGLVVVDENNKVVGILTVKDLL 261
            P  T+ E    M    I+ L V+     +VG++   DLL
Sbjct: 235 TPHMTVYEVAKKMVKYRIEQLPVIKGEGDLVGLIRDFDLL 274


>gb|AAK43302.1| Conserved hypothetical protein [Sulfolobus solfataricus]
           Length = 277
           
 Score = 72.6 bits (175), Expect = 7e-12
 Identities = 61/250 (24%), Positives = 127/250 (50%), Gaps = 29/250 (11%)

Query: 38  ILVFDDNVYKGVLTQDLI--IRSHLK--------WDPTKAKVRDVYKPAPV-VKPTDDLS 86
           I+V ++ +   + T+DL+  + S+ K        +  +   + D   P PV V  T D  
Sbjct: 35  IIVANEKIEGLLTTRDLLSTVESYCKDSCSQGDLYHISTTPIIDYMTPNPVTVYNTSDEF 94

Query: 87  HAAKLLLETDLRSLPVGENKAEILGVISD--MALLERVVAEEFGKRKVEEFMTKDVITLG 144
            A  +++  +  SLPV +   + +G++++    LL + + E F    V+ FM+  V T+ 
Sbjct: 95  TAINIMVTRNFGSLPVVDINDKPVGIVTEREFLLLYKDLDEIF---PVKVFMSTKVQTIY 151

Query: 145 PDDTVAKALATMRDHGISRIPVVDEEGKLEGLVTLHDLIIRFIKPRFKAQYGELAGEKIP 204
            +  + +A+  M   G  R+PV+D++ K+ G+VT+ + I +  K          A +K+ 
Sbjct: 152 KEVRLDQAVKLMLRRGFRRLPVIDDDNKVVGIVTVVNAIKQLAK----------AVDKLD 201

Query: 205 P---FSMKLREAMIKGVITIMPEATIREAVSTMKDNNIDGLVVVDENNKVVGILTVKDLL 261
           P   +   +++ M+  ++TI   A++  A + M    I  L++++++N + GI+T +DLL
Sbjct: 202 PDYFYGKVVKDVMVTNLVTIDELASVNRAAAEMIVKRIGSLLILNKDNTIRGIITERDLL 261

Query: 262 LPISRMVEKE 271
           + +  ++  E
Sbjct: 262 IALHHILVME 271


>pir||H72780 hypothetical protein APE0233 - Aeropyrum pernix (strain K1)
           >gi|5103625|dbj|BAA79146.1| (AP000058) 340aa long
           hypothetical protein [Aeropyrum pernix]
           Length = 340
           
 Score = 72.6 bits (175), Expect = 7e-12
 Identities = 52/194 (26%), Positives = 103/194 (52%), Gaps = 7/194 (3%)

Query: 79  VKPTDDLSHAAKLLLETDLRSLPVGENKAEILGVISDMALLERVVAEEFGKRKVEEFMTK 138
           V  +DDL    ++++   +  LPV  +   + GVI++  +L R+    F K KV ++MT 
Sbjct: 152 VSVSDDLDTILRIMVGEGIGFLPVLYDDGTLHGVITERNILGRIADIPFDK-KVGDYMTA 210

Query: 139 DVITLGPDDTVAKALATMRDHGISRIPVVDEE-GKLEGLVTLHDLIIRFIKPRFKAQYGE 197
            ++ + P+  + +A+ +M  +G  R+ V+    G+++G++T  D++  F     +A    
Sbjct: 211 TIVGVDPEAPLKEAMRSMVTYGFRRLLVISSSTGEIKGVITAKDIVAYF--GEHEAFKNA 268

Query: 198 LAGEKIPPFSMKLREAMIKGVITIMPEATIREAVSTMKDNNIDGLVVVDENNKVVGILTV 257
            +G+     S+ +   M   V TI  +A++ +A   M +  +D L+VVD   +  GI+T 
Sbjct: 269 PSGKVSEAISIPVYMVMSPEVYTIDEKASVADAARRMVELGVDSLIVVD-GGEAKGIITE 327

Query: 258 KDLLLPISRMVEKE 271
           +D+L  ++ +VE E
Sbjct: 328 RDVL--VASVVEGE 339


>sp|O67820|IMDH_AQUAE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (IMP DEHYDROGENASE) (IMPDH)
           (IMPD) >gi|7427683|pir||H70473 IMP dehydrogenase (EC
           1.1.1.205) - Aquifex aeolicus >gi|2984252|gb|AAC07779.1|
           (AE000768) inosine monophosphate dehydrogenase [Aquifex
           aeolicus]
           Length = 490
           
 Score = 71.8 bits (173), Expect = 1e-11
 Identities = 51/140 (36%), Positives = 74/140 (52%), Gaps = 18/140 (12%)

Query: 124 AEEFGK-RKVEEFMTKDVITLGPDDTVAKALATMRDHGISRIPVVDEEGKLEGLVTLHDL 182
           AEE  K +K E  M  + +T+ PD  V +AL  M  + IS +PVVDEE KL G++T  DL
Sbjct: 83  AEEVEKVKKSESGMIINPVTVKPDTRVKEALDIMAKYKISGVPVVDEERKLIGILTNRDL 142

Query: 183 IIRFIKPRFKAQYGELAGEKIPPFSMKLREAMIKGVITIMPEA-TIREAVSTMKDNNIDG 241
             RFIKP                +S  + E M K  +   PE  T+ EA    +   I+ 
Sbjct: 143 --RFIKPE--------------DYSKPVSEFMTKENLITAPEGITLDEAEEIFRKYKIEK 186

Query: 242 LVVVDENNKVVGILTVKDLL 261
           L +VD+  K+ G++T+KD++
Sbjct: 187 LPIVDKEGKIKGLITIKDIV 206


>pir||C71188 conserved hypothetical protein MJ1225 homolog - Pyrococcus
           horikoshii >gi|3258215|dbj|BAA30898.1| (AP000007) 285aa
           long hypothetical protein [Pyrococcus horikoshii]
           Length = 285
           
 Score = 71.0 bits (171), Expect = 2e-11
 Identities = 73/283 (25%), Positives = 125/283 (43%), Gaps = 28/283 (9%)

Query: 1   MVGIQVQEVMTDRYAKIDINAPLSEAIGIIEKEDPDLILVFDDNVYKGVLTQDLIIRSHL 60
           M+ ++V+ +MT     I + A  + A+ + +K       V +    +G L   + ++  L
Sbjct: 1   MIWVRVKTIMTQNPVTITLPATRNYALELFKKYKVRSFPVVNK---EGKLVGIISVKRIL 57

Query: 61  KWDPTKAKVRDVYKPAPVVKPTDDLSHAAKLLLETDLRSLPVGENKAEILGVISDMALLE 120
                +     V +  PVVK  D L  AAKL+LE D R + V ++K + +G+++   ++ 
Sbjct: 58  VNPDEEQLAMLVKRDVPVVKENDTLKKAAKLMLEYDYRRVVVVDSKGKPVGILTVGDIIR 117

Query: 121 RVVA--EEFGKRKVEEFMTKDVITLGPDDTVAKALATMRDHGISRIPVVDEEGKLEGLVT 178
           R  A  E++   ++E +  + V  +     +  AL  +       +PVVD EG L G+V 
Sbjct: 118 RYFAKSEKYKGVEIEPYYQRYVSIVWEGTPLKAALKALLLSNSMALPVVDSEGNLVGIVD 177

Query: 179 LHDL-----IIRFIKPRFKAQYGE----------LAGEKIPPFSMKL-----REAMIKGV 218
             DL     I+R +K    A   E          L  EK   F ++L      E M + V
Sbjct: 178 ETDLLRDSEIVRIMKSTELAASSEEEWILESHPTLLFEK---FELQLPNKPVAEIMTRDV 234

Query: 219 ITIMPEATIREAVSTMKDNNIDGLVVVDENNKVVGILTVKDLL 261
           I   P  T+ E    M   +I+ L V+     ++G++   DLL
Sbjct: 235 IVATPHMTVHEVALKMAKYSIEQLPVIRGEGDLIGLIRDFDLL 277


>pir||B72265 hypothetical protein TM1354 - Thermotoga maritima (strain MSB8)
           >gi|4981914|gb|AAD36425.1|AE001789_10 (AE001789)
           inosine-5-monophosphate dehydrogenase-related protein
           [Thermotoga maritima]
           Length = 321
           
 Score = 71.0 bits (171), Expect = 2e-11
 Identities = 37/105 (35%), Positives = 62/105 (58%), Gaps = 1/105 (0%)

Query: 79  VKPTDDLSHAAKLLLETDLRSLPVGENKAEILGVISDMALLERVVAEEFGKRKVEEFMTK 138
           V P   L H  +++    +  +PV ++K  ++G++S   ++ + +   + K  VE+ MTK
Sbjct: 29  VTPDKTLLHVKEIMRIKRISGVPVVDDKKRVVGIVSLEDII-KALEGSYIKDSVEKRMTK 87

Query: 139 DVITLGPDDTVAKALATMRDHGISRIPVVDEEGKLEGLVTLHDLI 183
           +V+ L   DT+  A+ T   +G  R PVVD+EGKL G+VT HD+I
Sbjct: 88  NVVCLKETDTLQDAVKTFEKYGYGRFPVVDDEGKLVGIVTKHDII 132


  Database: ./suso.pep
    Posted date:  Jul 6, 2001  5:57 PM
  Number of letters in database: 840,471
  Number of sequences in database:  2977
  
  Database: /banques/blast2/nr.pep
    Posted date:  Dec 14, 2000 12:46 PM
  Number of letters in database: 188,266,275
  Number of sequences in database:  595,510
  
Lambda     K      H
   0.321    0.141    0.394 

Gapped
Lambda     K      H
   0.270   0.0470    0.230 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 138639362
Number of Sequences: 2977
Number of extensions: 5939473
Number of successful extensions: 17748
Number of sequences better than 1.0e-10: 31
Number of HSP's better than  0.0 without gapping: 6
Number of HSP's successfully gapped in prelim test: 25
Number of HSP's that attempted gapping in prelim test: 17557
Number of HSP's gapped (non-prelim): 77
length of query: 392
length of database: 189,106,746
effective HSP length: 57
effective length of query: 335
effective length of database: 154,992,987
effective search space: 51922650645
effective search space used: 51922650645
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 41 (21.8 bits)
S2: 166 (69.1 bits)