BLASTP 2.0.10 [Aug-26-1999]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= PAB1008 (PAB1008) DE:HYPOTHETICAL DEHYDROGENASE
(333 letters)
Database: ./suso.pep; /banques/blast2/nr.pep
598,487 sequences; 189,106,746 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
pir||D75067 probable dehydrogenase PAB1008 - Pyrococcus abyssi (... 665 0.0
pir||C71165 probable dehydrogenase - Pyrococcus horikoshii >gi|3... 526 e-148
pir||B75057 glycerate dehydrogenase PAB2374 - Pyrococcus abyssi ... 265 4e-70
pir||A71175 probable dehydrogenase - Pyrococcus horikoshii >gi|3... 264 9e-70
pir||E72568 probable D-3-phosphoglycerate dehydrogenase APE1831 ... 235 8e-61
pir||E71011 probable phosphoglycerate dehydrogenase - Pyrococcus... 213 3e-54
sp|O27051|SERA_METTH D-3-PHOSPHOGLYCERATE DEHYDROGENASE (PGDH) >... 210 2e-53
pir||B75120 phosphoglycerate dehydrogenase truncated homolog PAB... 206 3e-52
sp|Q58424|SERA_METJA D-3-PHOSPHOGLYCERATE DEHYDROGENASE (PGDH) >... 201 1e-50
pir||H70032 glycerate dehydrogenase homolog yvcT - Bacillus subt... 195 5e-49
emb|CAB08066.1| (Z94043) hypothetical protein [Bacillus subtilis] 195 5e-49
dbj|BAB07033.1| (AP001518) glycerate dehydrogenase [Bacillus hal... 190 2e-47
pir||A70464 D-3-phosphoglycerate dehydrogenase - Aquifex aeolicu... 181 1e-44
gb|AAF79644.1|AC025416_18 (AC025416) F5O11.29 [Arabidopsis thali... 178 1e-43
pir||C83158 probable 2-hydroxyacid dehydrogenase PA3896 [importe... 177 1e-43
gi|11499368 2-hydroxyacid dehydrogenase, putative [Archaeoglobus... 176 2e-43
pir||B72257 D-3-phosphoglycerate dehydrogenase - Thermotoga mari... 174 2e-42
gb|AAD21956.1| (AF101234) unknown [Staphylococcus aureus] 174 2e-42
pir||C72483 probable formate dehydrogenase APE2507 - Aeropyrum p... 170 2e-41
sp|O04130|SERA_ARATH D-3-PHOSPHOGLYCERATE DEHYDROGENASE PRECURSO... 169 5e-41
pir||F83362 probable 2-hydroxyacid dehydrogenase PA2263 [importe... 168 7e-41
sp|P73821|SERA_SYNY3 D-3-PHOSPHOGLYCERATE DEHYDROGENASE (PGDH) >... 168 9e-41
gi|11498419 phosphoglycerate dehydrogenase (serA) [Archaeoglobus... 168 1e-40
pir||T35831 probable D-3-phosphoglycerate dehydrogenase - Strept... 166 3e-40
dbj|BAB05321.1| (AP001512) D-3-phosphoglycerate dehydrogenase [B... 165 6e-40
sp|O53243|SERA_MYCTU D-3-PHOSPHOGLYCERATE DEHYDROGENASE (PGDH) >... 164 1e-39
gb|AAF09059.1|AC011717_26 (AC011717) putative D-isomer specific ... 164 1e-39
pir||T00876 hypothetical protein F17K2.16 - Arabidopsis thaliana... 163 2e-39
sp|O33116|SERA_MYCLE D-3-PHOSPHOGLYCERATE DEHYDROGENASE (PGDH) >... 159 4e-38
pir||S47774 hypothetical protein o365 - Escherichia coli >gi|466... 159 6e-38
sp|P35136|SERA_BACSU D-3-PHOSPHOGLYCERATE DEHYDROGENASE (PGDH) >... 159 6e-38
sp|P37666|YIAE_ECOLI PROBABLE 2-HYDROXYACID DEHYDROGENASE IN BIS... 158 7e-38
pir||C65154 probable 2-hydroxyacid dehydrogenase in bisC-cspA in... 158 7e-38
pir||A72390 hypothetical protein TM0327 - Thermotoga maritima (s... 156 4e-37
pir||T51423 formate dehydrogenase (FDH) - Arabidopsis thaliana >... 154 1e-36
gi|5729974 phosphoglycerate dehydrogenase; 3-phosphoglycerate de... 152 4e-36
gi|11422415 phosphoglycerate dehydrogenase [Homo sapiens] 152 4e-36
gb|AAC71709.1| (AF061070) PtxD [Pseudomonas stutzeri] 152 6e-36
emb|CAA21970.1| (AL033497) YNL274C homologue [Candida albicans] 152 7e-36
sp|O08651|SERA_RAT D-3-PHOSPHOGLYCERATE DEHYDROGENASE (PGDH) >gi... 151 1e-35
dbj|BAA99698.1| (AB025624) phosphoglycerate dehydrogenase [Arabi... 151 1e-35
gb|AAF51963.1| (AE003602) CG1236 gene product [Drosophila melano... 151 1e-35
gb|AAF00955.1|AF183408_3 (AF183408) McyI [Microcystis aeruginosa] 150 2e-35
emb|CAC11910.1| (AL445065) 2-hydroxyacid dehydrogenase related p... 150 2e-35
dbj|BAB12215.1| (AB032549) d-3-phosphoglycerate dehydrogenase [M... 149 5e-35
pir||T05416 probable phosphoglycerate dehydrogenase (EC 1.1.1.95... 148 1e-34
pir||G70363 D-lactate dehydrogenase - Aquifex aeolicus >gi|29833... 148 1e-34
emb|CAB61802.1| (AL133236) putative dehydrogenase [Streptomyces ... 147 2e-34
pir||D83529 D-lactate dehydrogenase (fermentative) PA0927 [impor... 146 2e-34
sp|Q07511|FDH_SOLTU MITOCHONDRIAL FORMATE DEHYDROGENASE PRECURSO... 146 3e-34
gb|AAF53930.1| (AE003668) CG9332 gene product [Drosophila melano... 145 7e-34
sp|O88712|CTB1_MOUSE C-TERMINAL BINDING PROTEIN 1 >gi|3452507|em... 144 2e-33
gb|AAD14596.1| (AF091554) C-terminal binding protein [Xenopus la... 144 2e-33
gi|7304989 C-terminal binding protein 1 [Mus musculus] >gi|60154... 144 2e-33
gi|4557497 C-terminal binding protein 1 [Homo sapiens] >gi|11436... 143 2e-33
gi|9506527 C-terminal binding protein 1 [Rattus norvegicus] >gi|... 143 3e-33
gi|4557499 C-terminal binding protein 2 [Homo sapiens] >gi|11432... 142 5e-33
gi|6753548 C-terminal binding protein 2 [Mus musculus] >gi|35135... 142 6e-33
pir||T19602 hypothetical protein C31C9.2 - Caenorhabditis elegan... 141 1e-32
gb|AAD41370.1|AF152006_1 (AF152006) Tcf-3 co-repressor CtBP [Xen... 141 1e-32
sp|P43885|SERA_HAEIN D-3-PHOSPHOGLYCERATE DEHYDROGENASE (PGDH) >... 140 2e-32
gb|AAF53929.1| (AE003668) CG9331 gene product [Drosophila melano... 140 2e-32
gi|6912396 glyoxylate reductase/hydroxypyruvate reductase [Homo ... 139 3e-32
sp|Q61753|SERA_MOUSE D-3-PHOSPHOGLYCERATE DEHYDROGENASE (PGDH) (... 139 3e-32
dbj|BAA77337.1| (AB019533) Nad-dependent formate dehydrogenase [... 139 3e-32
sp|P44501|DDH_HAEIN 2-HYDROXYACID DEHYDROGENASE HOMOLOG >gi|1073... 139 4e-32
gi|6324055 Ynl274cp [Saccharomyces cerevisiae] >gi|1730640|sp|P5... 139 5e-32
sp|P56546|CTB2_MOUSE C-TERMINAL BINDING PROTEIN 2 >gi|2909779|gb... 138 7e-32
pir||H64531 phosphoglycerate dehydrogenase - Helicobacter pylori... 137 2e-31
gb|AAG20511.1| (AE005123) phosphoglycerate dehydrogenase; SerA1 ... 137 2e-31
sp|Q07103|FDH_NEUCR FORMATE DEHYDROGENASE (NAD-DEPENDENT FORMATE... 137 2e-31
pir||G71974 probable keto-acid dehydrogenase - Helicobacter pylo... 137 2e-31
pir||C81380 probable D-2-hydroxyacid dehydrogenase Cj0373 [impor... 137 2e-31
pir||C81362 phosphoglycerate dehydrogenase (EC 1.1.1.95) Cj0891c... 136 3e-31
emb|CAA12074.1| (AJ224690) C-terminal binding protein [Drosophil... 136 4e-31
gb|AAF54891.1| (AE003698) CtBP gene product [alt 2] [Drosophila ... 136 4e-31
pir||S48189 hydroxypyruvate reductase (EC 1.1.1.81) - Hyphomicro... 136 5e-31
dbj|BAA25287.1| (AB011840) CtBP [Drosophila melanogaster] 136 5e-31
pir||D71373 probable D-specific D-2-hydroxyacid dehydrogenase - ... 135 8e-31
gb|AAG34690.1|AF310956_5 (AF310956) D-2-hydroxyacid dehydrogenas... 135 8e-31
pir||S75499 D-isomer specific 2-hydroxyacid dehydrogenase family... 134 1e-30
sp|Q59516|DHGY_METEX GLYCERATE DEHYDROGENASE (NADH-DEPENDENT HYD... 134 1e-30
gb|AAG10470.1|AF279106_32 (AF279106) predicted NAD-dependent for... 134 2e-30
gb|AAD19834.1| (AF060799) D-lactate dehydrogenase [Amycolatopsis... 133 2e-30
dbj|BAA36181.1| (D88272) formate dehydrogenase [Hordeum vulgare] 133 3e-30
gb|AAF16561.1|AC012563_14 (AC012563) hydroxypyruvate reductase (... 132 4e-30
sp|P52643|LDHD_ECOLI D-LACTATE DEHYDROGENASE (D-LDH) >gi|7431359... 132 7e-30
emb|CAA73696.1| (Y13245) NAD-dependent formate dehydrogenase [Mo... 132 7e-30
sp|P30799|DDH_ZYMMO 2-HYDROXYACID DEHYDROGENASE HOMOLOG >gi|5387... 131 9e-30
pir||A75414 D-3-phosphoglycerate dehydrogenase - Deinococcus rad... 131 9e-30
pir||T50134 2-hydroxyacid dehydrogenase [imported] - fission yea... 131 9e-30
pdb|2NAD|A Chain A, Nad-Dependent Formate Dehydrogenase (E.C.1.2... 131 1e-29
gb|AAB36206.1| NAD(+)-dependent formate dehydrogenase, McFDH {EC... 131 1e-29
sp|P33160|FDH_PSESR FORMATE DEHYDROGENASE (NAD-DEPENDENT FORMATE... 131 1e-29
gb|AAF72362.1|AF192329_23 (AF192329) VanHB [Enterococcus faecalis] 131 1e-29
sp|Q05709|VANH_ENTFC D-SPECIFIC ALPHA-KETO ACID DEHYDROGENASE (V... 131 2e-29
dbj|BAA19751.1| (D85339) hydroxypyruvate reductase [Arabidopsis ... 131 2e-29
gb|AAF19554.1|AC005761_2 (AC005761) D-3-phosphoglycerate dehydro... 131 2e-29
sp|P45250|YF56_HAEIN PUTATIVE 2-HYDROXYACID DEHYDROGENASE HI1556... 130 3e-29
pir||F82022 probable glycerate dehydrogenase (EC 1.1.1.29) NMA02... 129 5e-29
pir||JU0334 formate dehydrogenase (EC 1.2.1.2) - Pseudomonas sp 129 6e-29
sp|P87228|SERA_SCHPO PUTATIVE D-3-PHOSPHOGLYCERATE DEHYDROGENASE... 128 1e-28
gb|AAC23583.1| (U82965) D-lactate dehydrogenase [Streptomyces to... 128 1e-28
sp|Q47748|VANH_ENTFA D-SPECIFIC ALPHA-KETO ACID DEHYDROGENASE (V... 127 1e-28
pir||S68164 glycerate dehydrogenase (EC 1.1.1.29) splice form HP... 127 2e-28
pir||S68165 glycerate dehydrogenase (EC 1.1.1.29) splice form HP... 127 2e-28
sp|P13443|DHGY_CUCSA GLYCERATE DEHYDROGENASE (NADH-DEPENDENT HYD... 127 2e-28
gi|9631622 contains D-isomer specific 2-hydroxyacid dehydrogenas... 127 2e-28
pir||T42743 hypothetical protein - fission yeast (Schizosaccharo... 126 3e-28
pir||T41705 probable 2-hydroxyacid dehydrogenase - fission yeast... 126 3e-28
pdb|1GDH|A Chain A, D-Glycerate Dehydrogenase (Apo Form) (E.C.1.... 125 7e-28
sp|P36234|DHGY_HYPME GLYCERATE DEHYDROGENASE (NADH-DEPENDENT HYD... 125 7e-28
sp|Q03134|FDH_EMENI PROBABLE FORMATE DEHYDROGENASE (NAD-DEPENDEN... 125 9e-28
gb|AAD23831.1|AF123482_1 (AF123482) NAD-dependent formate dehydr... 125 9e-28
pir||H81245 glycerate dehydrogenase NMB0029 [imported] - Neisser... 125 9e-28
gb|AAF53080.1| (AE003631) CG6287 gene product [Drosophila melano... 124 2e-27
pir||F69895 phosphoglycerate dehydrogenase homolog yoaD - Bacill... 123 3e-27
gb|AAC46259.1| (AF006000) D-3-phosphoglycerate dehydrogenase hom... 123 3e-27
gb|AAF36802.1|AF155139_1 (AF155139) putative lactate dehydrogena... 123 3e-27
emb|CAB61228.1| (Y15705) vanh protein [Bacillus circulans] 122 6e-27
pir||F81053 D-lactate dehydrogenase NMB1685 [imported] - Neisser... 122 6e-27
pir||T35362 probable D-lactate dehydrogenase - Streptomyces coel... 122 8e-27
pir||C71864 d-3-phosphoglycerate dehydrogenase - Helicobacter py... 121 1e-26
gb|AAC28494.1| (AF079881) D-3-phosphoglycerate dehydrogenase [En... 120 2e-26
pir||C82072 D-3-phosphoglycerate dehydrogenase VC2481 [imported]... 120 2e-26
sp|P08328|SERA_ECOLI D-3-PHOSPHOGLYCERATE DEHYDROGENASE (PGDH) >... 120 2e-26
pdb|1PSD|A Chain A, D-3-Phosphoglycerate Dehydrogenase (Phosphog... 120 2e-26
gi|6320925 3-phosphoglycerate dehydrogenase; Ser3p [Saccharomyce... 120 3e-26
pir||E64569 phosphoglycerate dehydrogenase - Helicobacter pylori... 118 7e-26
pir||F82068 2-hydroxyacid dehydrogenase family protein VC2504 [i... 118 9e-26
gi|6322116 3-phosphoglycerate dehydrogenase; Ser33p [Saccharomyc... 118 1e-25
gb|AAD51059.1|AF175293_4 (AF175293) D-lactate dehydrogenase [Ent... 118 1e-25
gb|AAK41187.1| D-3-phosphoglycerate dehydrogenase (serA-1) [Sulf... 117 2e-25
pir||S45534 phosphoglycerate dehydrogenase (EC 1.1.1.95) - Bacil... 117 2e-25
pir||C83607 D-3-phosphoglycerate dehydrogenase PA0316 [imported]... 115 6e-25
gb|AAC49766.1| (AF004096) NAD-dependent formate dehydrogenase [C... 115 8e-25
emb|CAA09466.2| (AJ011046) formate dehydrogenase [Candida boidinii] 115 8e-25
sp|P26298|LDHD_LACPE D-LACTATE DEHYDROGENASE (D-LDH) >gi|98677|p... 115 1e-24
gb|AAG21503.1|AC067754_18 (AC067754) phosphoglycerate dehydrogen... 115 1e-24
pir||JC4252 formate dehydrogenase (EC 1.2.1.2) - yeast (Candida ... 114 2e-24
dbj|BAB04668.1| (AP001510) D-3-phosphoglycerate dehydrogenase [B... 113 2e-24
dbj|BAA14985.1| (D90775) D-lactate dehydrogenase (EC 1.1.1.28) (... 112 5e-24
sp|P30901|LDHD_LACHE D-LACTATE DEHYDROGENASE (D-LDH) >gi|478777|... 111 9e-24
gb|AAC99363.1| (AF071558) D-lactate dehydrogenase [Lactobacillus... 111 9e-24
sp|Q59642|LDHD_PEDAC D-LACTATE DEHYDROGENASE (D-LDH) >gi|897794|... 111 1e-23
pir||C70645 hypothetical protein Rv0728c - Mycobacterium tubercu... 110 2e-23
pir||T34290 hypothetical protein F49E10.5 - Caenorhabditis elega... 109 3e-23
emb|CAA04756.1| (AJ001428) D-mandelate dehydrogenase [Rhodotorul... 109 3e-23
prf||2124425A CtBP protein [Rattus norvegicus] 109 4e-23
dbj|BAA13058.1| (D86240) unknown [Staphylococcus aureus] 109 6e-23
emb|CAA42781.1| (X60220) D-lactate dehydrogenase [Lactobacillus... 106 4e-22
gb|AAG39286.1|AF113215_1 (AF113215) MSTP035 [Homo sapiens] 106 4e-22
pir||T35499 probable D-lactate dehydrogenase - Streptomyces coel... 105 9e-22
pdb|1QP8|A Chain A, Crystal Structure Of A Putative Formate Dehy... 104 1e-21
pir||D75365 probable 2-hydroxyacid dehydrogenase - Deinococcus r... 104 1e-21
pir||B82587 D-3-phosphoglycerate dehydrogenase XF2206 [imported]... 104 2e-21
pir||C82118 erythronate-4-phosphate dehydrogenase VC2108 [import... 102 4e-21
sp|P26297|LDHD_LACDE D-LACTATE DEHYDROGENASE (D-LDH) >gi|538959|... 102 6e-21
pir||JC7190 D-2-hydroxy-acid dehydrogenase (EC 1.1.99.6) - human... 101 1e-20
emb|CAC04225.1| (AL391515) putative dehydrogenase [Streptomyces ... 100 3e-20
pir||S51787 D-2-hydroxyisocaproate dehydrogenase (EC 1.1.1.-) - ... 99 5e-20
sp|P17584|DHD2_LACCA D-2-HYDROXYISOCAPROATE DEHYDROGENASE (D-HIC... 99 9e-20
emb|CAC11987.1| (AL445065) glycerate dehydrogenase related prote... 99 9e-20
pir||DELBC D-2-hydroxyisocaproate dehydrogenase (EC 1.1.1.-) - L... 98 1e-19
pir||S48145 D-hydroxyisocaproate dehydrogenase - Lactobacillus d... 98 1e-19
gb|AAG19748.1| (AE005060) phosphoglycerate dehydrogenase; SerA2 ... 97 3e-19
gb|AAG18731.1| (AE004977) phosphoglycerate dehydrogenase; SerA3 ... 94 2e-18
sp|P05459|PDXB_ECOLI ERYTHRONATE-4-PHOSPHATE DEHYDROGENASE >gi|6... 94 3e-18
sp|P51011|LDHD_LEUMC D-LACTATE DEHYDROGENASE (D-LDH) >gi|508506|... 93 4e-18
gb|AAD51414.1|AF171236_1 (AF171236) 3-phosphoglycerate dehydroge... 93 4e-18
gi|6321253 Ygl185cp [Saccharomyces cerevisiae] >gi|1723944|sp|P5... 92 6e-18
emb|CAB92262.1| (AL356595) putative 2-hydroxyacid dehydrogenase ... 91 2e-17
emb|CAB56144.1| (AL117669) putative dehydrogenase [Streptomyces ... 86 5e-16
pir||D82435 D-3-phosphoglycerate dehydrogenase-related protein V... 78 2e-13
emb|CAB55710.1| (AL117387) possible dehydrogenase [Streptomyces ... 77 3e-13
gb|AAK43287.1| D-3-phosphoglycerate dehydrogenase, putative (se... 69 5e-11
>pir||D75067 probable dehydrogenase PAB1008 - Pyrococcus abyssi (strain Orsay)
>gi|5458946|emb|CAB50433.1| (AJ248287) hypothetical
DEHYDROGENASE [Pyrococcus abyssi]
Length = 333
Score = 665 bits (1696), Expect = 0.0
Identities = 333/333 (100%), Positives = 333/333 (100%)
Query: 1 MKPRIGVLFKMKSKPLEELKKYTDVVLKPYPSEEELKEIIPELDGIIIAPVTRITKDILE 60
MKPRIGVLFKMKSKPLEELKKYTDVVLKPYPSEEELKEIIPELDGIIIAPVTRITKDILE
Sbjct: 1 MKPRIGVLFKMKSKPLEELKKYTDVVLKPYPSEEELKEIIPELDGIIIAPVTRITKDILE 60
Query: 61 RAERLKVISCQSAGYDHVDVEEATKRGIYVTKVSGLLSEAVAEFALGLLISLMRKIHYAD 120
RAERLKVISCQSAGYDHVDVEEATKRGIYVTKVSGLLSEAVAEFALGLLISLMRKIHYAD
Sbjct: 61 RAERLKVISCQSAGYDHVDVEEATKRGIYVTKVSGLLSEAVAEFALGLLISLMRKIHYAD 120
Query: 121 SFIREGKWESHTFVWREFKEVETLYGKEVGIVGMGAIGKAIARRLKPFGCEIYYWSRHRK 180
SFIREGKWESHTFVWREFKEVETLYGKEVGIVGMGAIGKAIARRLKPFGCEIYYWSRHRK
Sbjct: 121 SFIREGKWESHTFVWREFKEVETLYGKEVGIVGMGAIGKAIARRLKPFGCEIYYWSRHRK 180
Query: 181 EDIEREVNAKYLDLDELLEEVDIVILALPLTKETYHIINEERVKKLEGKYLVNIGRGALI 240
EDIEREVNAKYLDLDELLEEVDIVILALPLTKETYHIINEERVKKLEGKYLVNIGRGALI
Sbjct: 181 EDIEREVNAKYLDLDELLEEVDIVILALPLTKETYHIINEERVKKLEGKYLVNIGRGALI 240
Query: 241 DEKALVKAIKEGKLKGFATDVFEEEPVKEHELFRFKWETVLTPHYAGLGKDVLEDMGFRA 300
DEKALVKAIKEGKLKGFATDVFEEEPVKEHELFRFKWETVLTPHYAGLGKDVLEDMGFRA
Sbjct: 241 DEKALVKAIKEGKLKGFATDVFEEEPVKEHELFRFKWETVLTPHYAGLGKDVLEDMGFRA 300
Query: 301 VENLLKVLRGEIPEDLVNKEVLKVRPIDEVKML 333
VENLLKVLRGEIPEDLVNKEVLKVRPIDEVKML
Sbjct: 301 VENLLKVLRGEIPEDLVNKEVLKVRPIDEVKML 333
>pir||C71165 probable dehydrogenase - Pyrococcus horikoshii
>gi|3256925|dbj|BAA29608.1| (AP000002) 333aa long
hypothetical dehydrogenase [Pyrococcus horikoshii]
Length = 333
Score = 526 bits (1340), Expect = e-148
Identities = 248/333 (74%), Positives = 299/333 (89%)
Query: 1 MKPRIGVLFKMKSKPLEELKKYTDVVLKPYPSEEELKEIIPELDGIIIAPVTRITKDILE 60
M+P++GVL KMK + LEELKKY DV + YPS EELK +I DGII++P T+IT+++LE
Sbjct: 1 MRPKVGVLLKMKREALEELKKYADVEIILYPSGEELKGVIGRFDGIIVSPTTKITREVLE 60
Query: 61 RAERLKVISCQSAGYDHVDVEEATKRGIYVTKVSGLLSEAVAEFALGLLISLMRKIHYAD 120
AERLKVISC SAGYD++D+EEATKRGIYVTKVSGLLSEAVAEF +GL+I+LMRKIHYAD
Sbjct: 61 NAERLKVISCHSAGYDNIDLEEATKRGIYVTKVSGLLSEAVAEFTVGLIINLMRKIHYAD 120
Query: 121 SFIREGKWESHTFVWREFKEVETLYGKEVGIVGMGAIGKAIARRLKPFGCEIYYWSRHRK 180
FIR G+WESH +W FK +E+LYGK+VGI+GMGAIGKAIARRL PFG ++YYWSRHRK
Sbjct: 121 KFIRRGEWESHAKIWTGFKRIESLYGKKVGILGMGAIGKAIARRLIPFGVKLYYWSRHRK 180
Query: 181 EDIEREVNAKYLDLDELLEEVDIVILALPLTKETYHIINEERVKKLEGKYLVNIGRGALI 240
++E+E+ A+Y+D+DELLE+ DIVILALPLT++TYHIINEERVKKLEGKYLVNIGRGAL+
Sbjct: 181 VNVEKELKARYMDIDELLEKSDIVILALPLTRDTYHIINEERVKKLEGKYLVNIGRGALV 240
Query: 241 DEKALVKAIKEGKLKGFATDVFEEEPVKEHELFRFKWETVLTPHYAGLGKDVLEDMGFRA 300
DEKA+ +AIK+GKLKG+ATDVFE+EPV+EHELF+++WETVLTPHYAGL + ED+GFRA
Sbjct: 241 DEKAVTEAIKQGKLKGYATDVFEKEPVREHELFKYEWETVLTPHYAGLALEAQEDVGFRA 300
Query: 301 VENLLKVLRGEIPEDLVNKEVLKVRPIDEVKML 333
VENLLKVLRGE+PEDLVNKEVL+VRPI+ VKML
Sbjct: 301 VENLLKVLRGEVPEDLVNKEVLEVRPIENVKML 333
>pir||B75057 glycerate dehydrogenase PAB2374 - Pyrococcus abyssi (strain Orsay)
>gi|5458864|emb|CAB50351.1| (AJ248287) GLYCERATE
DEHYDROGENASE [Pyrococcus abyssi]
Length = 335
Score = 265 bits (671), Expect = 4e-70
Identities = 143/329 (43%), Positives = 206/329 (62%), Gaps = 6/329 (1%)
Query: 2 KPRIGVLFKMKSKPLEELKKYTDVVLKPYPSE---EELKEIIPELDGIIIAPVTRITKDI 58
KPR+ + ++ +E L+K +V + E E L E + ++D ++ RI +++
Sbjct: 3 KPRVFITREIPEVGIEMLEKEFEVEVWEDEREIPREILLEKVKDVDALVTMLSERIDREV 62
Query: 59 LERAERLKVISCQSAGYDHVDVEEATKRGIYVTKVSGLLSEAVAEFALGLLISLMRKIHY 118
ERA RL++++ + GYD++DVEEATKRGIYVT G+L++A A+ A LL++ R +
Sbjct: 63 FERAPRLRIVANYAVGYDNIDVEEATKRGIYVTNTPGVLTDATADLAFALLLATARHLVK 122
Query: 119 ADSFIREGKWESHTFVWR-EFKEVETLYGKEVGIVGMGAIGKAIARRLKPFGCEIYYWSR 177
D F R G+W+ W ++ +YGK +GI+G G IG+AIA+R + F I Y+SR
Sbjct: 123 GDKFTRSGEWKKRGVAWHPKWFLGYDVYGKTIGIIGFGRIGQAIAKRARGFDMRILYYSR 182
Query: 178 HRKEDIEREVNAKYLDLDELLEEVDIVILALPLTKETYHIINEERVKKLE-GKYLVNIGR 236
RK ++E+E+NA++ LDELL E D V+LA+PL KETYH+INEER+K ++ L+N+ R
Sbjct: 183 TRKPEVEKELNAEFKPLDELLRESDFVVLAVPLNKETYHMINEERLKMMKRTAILINVAR 242
Query: 237 GALIDEKALVKAIKEGKLKGFATDVFEEEPVKEHELFRFKWETVLTPHYAGLGKDVLEDM 296
G +ID KAL+KA+KEG + G DV+EEEP ELF VLTPH E M
Sbjct: 243 GKVIDTKALIKALKEGWIAGAGLDVYEEEPYYNEELFSLD-NVVLTPHIGSATFGAREGM 301
Query: 297 GFRAVENLLKVLRGEIPEDLVNKEVLKVR 325
ENL+ RGE+P LVN+EVLKVR
Sbjct: 302 AKLVAENLIAFKRGEVPPTLVNREVLKVR 330
>pir||A71175 probable dehydrogenase - Pyrococcus horikoshii
>gi|3257003|dbj|BAA29686.1| (AP000002) 376aa long
hypothetical dehydrogenase [Pyrococcus horikoshii]
Length = 376
Score = 264 bits (668), Expect = 9e-70
Identities = 140/331 (42%), Positives = 210/331 (63%), Gaps = 8/331 (2%)
Query: 1 MKPRIGVLFKMKSKPLEELKKYTDVVL----KPYPSEEELKEIIPELDGIIIAPVTRITK 56
MKP++ + ++ ++ L+ +V + K P E LK++ E+D ++ RI K
Sbjct: 43 MKPKVFITREIPEVGIKMLEDEFEVEVWGDEKEIPREILLKKV-KEVDALVTMLSERIDK 101
Query: 57 DILERAERLKVISCQSAGYDHVDVEEATKRGIYVTKVSGLLSEAVAEFALGLLISLMRKI 116
++ E A +L++++ + GYD++D+EEATKRGIYVT +L++A A+ A LL++ R +
Sbjct: 102 EVFENAPKLRIVANYAVGYDNIDIEEATKRGIYVTNTPDVLTDATADLAFALLLATARHV 161
Query: 117 HYADSFIREGKWESHTFVWR-EFKEVETLYGKEVGIVGMGAIGKAIARRLKPFGCEIYYW 175
D F+R G+W+ W ++ +YGK +GI+G+G IG+AIA+R K F I Y+
Sbjct: 162 VKGDRFVRSGEWKKRGVAWHPKWFLGYDVYGKTIGIIGLGRIGQAIAKRAKGFNMRILYY 221
Query: 176 SRHRKEDIEREVNAKYLDLDELLEEVDIVILALPLTKETYHIINEERVKKL-EGKYLVNI 234
SR RKE++ERE+NA++ L++LL E D V+LA+PLT+ETYH+INEER+K + + L+NI
Sbjct: 222 SRTRKEEVERELNAEFKPLEDLLRESDFVVLAVPLTRETYHLINEERLKLMKKTAILINI 281
Query: 235 GRGALIDEKALVKAIKEGKLKGFATDVFEEEPVKEHELFRFKWETVLTPHYAGLGKDVLE 294
RG ++D ALVKA+KEG + G DVFEEEP ELF+ VLTPH E
Sbjct: 282 ARGKVVDTNALVKALKEGWIAGAGLDVFEEEPYYNEELFKLD-NVVLTPHIGSASFGARE 340
Query: 295 DMGFRAVENLLKVLRGEIPEDLVNKEVLKVR 325
M +NL+ RGEIP LVN+EV+K+R
Sbjct: 341 GMAELVAKNLIAFKRGEIPPTLVNREVIKIR 371
>pir||E72568 probable D-3-phosphoglycerate dehydrogenase APE1831 - Aeropyrum
pernix (strain K1) >gi|5105521|dbj|BAA80834.1|
(AP000062) 347aa long hypothetical D-3-phosphoglycerate
dehydrogenase [Aeropyrum pernix]
Length = 347
Score = 235 bits (592), Expect = 8e-61
Identities = 140/330 (42%), Positives = 197/330 (59%), Gaps = 7/330 (2%)
Query: 2 KPRIGVLFKMKSKPLEELKKYTDV-VLKPY--PSEEELKEIIPELDGIIIAPVTRITKDI 58
+PR+ V ++ + LE L KY DV V Y P E L E D + RI D+
Sbjct: 15 RPRVFVTREVFPEALELLSKYYDVEVWDKYQPPPYETLLSKAREADALYTLLTDRIDCDL 74
Query: 59 LERAERLKVISCQSAGYDHVDVEEATKRGIYVTKVSGLLSEAVAEFALGLLISLMRKIHY 118
L +A RL++++ + G+D++DVE AT+ GIYVT G+L+EA AEF L+++ R++
Sbjct: 75 LSQAPRLRIVAQMAVGFDNIDVECATRLGIYVTNTPGVLTEATAEFTWALILAAARRVVE 134
Query: 119 ADSFIREGKWESHTFVWREFKEVET-LYGKEVGIVGMGAIGKAIARRLKPFGCEIYYWSR 177
AD F+R G+W W + L GK +GI+GMG IG +A K FG I Y SR
Sbjct: 135 ADHFVRWGEWWRLRTGWHPMMMLGVELRGKTLGILGMGRIGSRVAEIGKAFGMRIIYHSR 194
Query: 178 HRKEDIEREVNAKYLDLDELLEEVDIVILALPLTKETYHIINEERVKKLEGK-YLVNIGR 236
RK +IE+E+ A+Y L++LL E DI+ + LPLT ET H+I E +K ++ LVN GR
Sbjct: 195 SRKREIEKELGAEYRSLEDLLRESDILSIHLPLTDETRHLIGESELKLMKKTAILVNTGR 254
Query: 237 GALIDEKALVKAIKEGKLKGFATDVFEEEPVK-EHELFRFKWETVLTPHYAGLGKDVLED 295
GA++D ALVKA++EG + A DVFEEEP+ H L FK VL PH A ++
Sbjct: 255 GAIVDTGALVKALREGWIAAAALDVFEEEPLNPNHPLTAFK-NVVLAPHAASATRETRLR 313
Query: 296 MGFRAVENLLKVLRGEIPEDLVNKEVLKVR 325
M A ENL+ +G++P +LVN+EV+KVR
Sbjct: 314 MAMMAAENLVAFAQGKVPPNLVNREVVKVR 343
>pir||E71011 probable phosphoglycerate dehydrogenase - Pyrococcus horikoshii
>gi|3257810|dbj|BAA30493.1| (AP000006) 307aa long
hypothetical phosphoglycerate dehydrogenase [Pyrococcus
horikoshii]
Length = 307
Score = 213 bits (536), Expect = 3e-54
Identities = 118/310 (38%), Positives = 185/310 (59%), Gaps = 10/310 (3%)
Query: 4 RIGVLFKMKSKPLEELKKY-TDVVLKPYPSEEELKEIIPELDGIIIAPVTRITKDILERA 62
++ V + K ++ LK +V+ + YP E+ L E++ +++ II+ ++T+ ++E A
Sbjct: 5 KVLVAAPLHEKAIQVLKDAGLEVIYEEYPDEDRLVELVKDVEAIIVRSKPKVTRRVIESA 64
Query: 63 ERLKVISCQSAGYDHVDVEEATKRGIYVTKVSGLLSEAVAEFALGLLISLMRKIHYADSF 122
+LKVI+ G D++DVE A ++GI V S +VAE A+GL+ S+ RKI +AD
Sbjct: 65 PKLKVIARAGVGLDNIDVEAAKEKGIEVVNAPAASSRSVAELAVGLMFSVARKIAFADRK 124
Query: 123 IREGKWESHTFVWREFKEVETLYGKEVGIVGMGAIGKAIARRLKPFGCEIYYWSRHRKED 182
+REG W +E +E L GK +GI+G G IG +A+ G I + + E+
Sbjct: 125 MREGVWAK-----KEAMGIE-LEGKTIGIIGFGRIGYQVAKIANALGMNILLYDPYPNEE 178
Query: 183 IEREVNAKYLDLDELLEEVDIVILALPLTKETYHIINEERVKKL-EGKYLVNIGRGALID 241
+EVN K++DL+ LL+E D+V + +PL + TYH+INEER+K + + L+N RG ++D
Sbjct: 179 RAKEVNGKFVDLETLLKESDVVTIHVPLVESTYHLINEERLKLMKKTAILINTSRGPVVD 238
Query: 242 EKALVKAIKEGKLKGFATDVFEEEPV-KEHELFRFKWETVLTPHYAGLGKDVLEDMGFRA 300
ALVKA+KEG + G DVFEEEP+ K+H L +F VLTPH + E G
Sbjct: 239 TNALVKALKEGWIAGAGLDVFEEEPLPKDHPLTKFD-NVVLTPHIGASTVEAQERAGVEV 297
Query: 301 VENLLKVLRG 310
E ++K+L+G
Sbjct: 298 AEKVVKILKG 307
>sp|O27051|SERA_METTH D-3-PHOSPHOGLYCERATE DEHYDROGENASE (PGDH) >gi|7431368|pir||H69229
phosphoglycerate dehydrogenase - Methanobacterium
thermoautotrophicum (strain Delta H)
>gi|2622068|gb|AAB85466.1| (AE000870) phosphoglycerate
dehydrogenase [Methanobacterium thermoautotrophicum]
Length = 525
Score = 210 bits (528), Expect = 2e-53
Identities = 115/313 (36%), Positives = 179/313 (56%), Gaps = 8/313 (2%)
Query: 11 MKSKPLEELKKYTDVVLKPYPSEEELKEIIPELDGIIIAPVTRITKDILERAERLKVISC 70
+ K + EL++ +VV+ + EEL + I + D I++ T++T++++E A RLK+I+
Sbjct: 12 INEKGISELEEVAEVVVNTTITPEELLDAIKDFDAIVVRSRTKVTREVIEAAPRLKIIAR 71
Query: 71 QSAGYDHVDVEEATKRGIYVTKVSGLLSEAVAEFALGLLISLMRKIHYADSFIREGKWES 130
G D+VDV+ AT RGI V S VAE ++GL+++L RKI AD ++EGKWE
Sbjct: 72 AGVGVDNVDVKAATDRGIMVINAPESTSITVAEHSIGLMLALARKIAIADRSVKEGKWEK 131
Query: 131 HTFVWREFKEVETLYGKEVGIVGMGAIGKAIARRLKPFGCEIYYWSRHRKEDIEREVNAK 190
+ F+ E L GK +GI+GMG IG + R K FG +I + + ++ E+
Sbjct: 132 NRFMGIE------LNGKTLGIIGMGRIGSQVVVRTKAFGMDIMVYDPYISKEAAEEMGVT 185
Query: 191 YLDLDELLEEVDIVILALPLTKETYHIINEERVKKL-EGKYLVNIGRGALIDEKALVKAI 249
DL+ LL E DIV + +PLT ET H+I+E+ K + + ++VN RG +IDE AL +A+
Sbjct: 186 VTDLETLLRESDIVTIHVPLTPETRHLISEDEFKLMKDTAFIVNCARGGIIDEDALYRAL 245
Query: 250 KEGKLKGFATDVFEEEPVKEHELFRFKWETVLTPHYAGLGKDVLEDMGFRAVENLLKVLR 309
K+G++ G A DVFEEEP + L + VLTPH + D + V +
Sbjct: 246 KDGEIAGAALDVFEEEPPEGSPLLELE-NVVLTPHIGASTSEAQRDAAIIVANEIKTVFQ 304
Query: 310 GEIPEDLVNKEVL 322
G P +++N V+
Sbjct: 305 GGAPRNVLNMPVM 317
>pir||B75120 phosphoglycerate dehydrogenase truncated homolog PAB0514 [imported]
- Pyrococcus abyssi (strain Orsay)
>gi|5458186|emb|CAB49675.1| (AJ248285) phosphoglycerate
dehydrogenase (serA), Nter fragment [Pyrococcus abyssi]
Length = 307
Score = 206 bits (519), Expect = 3e-52
Identities = 110/289 (38%), Positives = 173/289 (59%), Gaps = 9/289 (3%)
Query: 24 DVVLKPYPSEEELKEIIPELDGIIIAPVTRITKDILERAERLKVISCQSAGYDHVDVEEA 83
+V+ + YP E+ L E++ +++ II+ ++T+ ++E A +LKVI+ G D++DVE A
Sbjct: 26 EVIYEEYPEEDRLVELVKDVEAIIVRSKPKVTRKVIESAPKLKVIARAGVGLDNIDVEAA 85
Query: 84 TKRGIYVTKVSGLLSEAVAEFALGLLISLMRKIHYADSFIREGKWESHTFVWREFKEVET 143
+RGI V S +VAE A+ L+ ++ RKI +AD +REG W + E
Sbjct: 86 KERGIEVVNAPAASSRSVAELAVALMFAVARKIAFADRKMREGVWAKKQAMGIE------ 139
Query: 144 LYGKEVGIVGMGAIGKAIARRLKPFGCEIYYWSRHRKEDIEREVNAKYLDLDELLEEVDI 203
L GK +GI+G G IG +A+ + G + + + E+ +EV K++DL+ LL E DI
Sbjct: 140 LEGKTLGIIGFGRIGYQVAKIARALGMNLLLYDPYPNEERAKEVGGKFVDLETLLRESDI 199
Query: 204 VILALPLTKETYHIINEERVKKL-EGKYLVNIGRGALIDEKALVKAIKEGKLKGFATDVF 262
V + +PL + TYH+INEER+K + + L+N RGA++D ALVKA++EG + G DV+
Sbjct: 200 VTIHVPLLESTYHLINEERLKLMKKSAILINTSRGAVVDTNALVKALEEGWIAGAGLDVY 259
Query: 263 EEEPV-KEHELFRFKWETVLTPHYAGLGKDVLEDMGFRAVENLLKVLRG 310
EEEP+ K+H L +F VLTPH + E G E ++K+L+G
Sbjct: 260 EEEPLPKDHPLTKFD-NVVLTPHIGASTVEAQERAGVEVAEKVVKILKG 307
>sp|Q58424|SERA_METJA D-3-PHOSPHOGLYCERATE DEHYDROGENASE (PGDH) >gi|2129189|pir||A64427
phosphoglycerate dehydrogenase (EC 1.1.1.95) -
Methanococcus jannaschii >gi|1591676|gb|AAB99020.1|
(U67544) phosphoglycerate dehydrogenase (serA)
[Methanococcus jannaschii]
Length = 524
Score = 201 bits (505), Expect = 1e-50
Identities = 108/302 (35%), Positives = 181/302 (59%), Gaps = 9/302 (2%)
Query: 32 SEEELKEIIPELDGIIIAPVTRITKDILERAERLKVISCQSAGYDHVDVEEATKRGIYVT 91
++EEL E I + D +++ T++T+D++E+AE+LKVI G D++DVE AT++GI V
Sbjct: 31 TKEELLEKIKDADVLVVRSGTKVTRDVIEKAEKLKVIGRAGVGVDNIDVEAATEKGIIVV 90
Query: 92 KVSGLLSEAVAEFALGLLISLMRKIHYADSFIREGKWESHTFVWREFKEVETLYGKEVGI 151
S +VAE +GL+++ R I A + ++ G+W+ + FK +E LYGK +G+
Sbjct: 91 NAPDASSISVAELTMGLMLAAARNIPQATASLKRGEWDR-----KRFKGIE-LYGKTLGV 144
Query: 152 VGMGAIGKAIARRLKPFGCEIYYWSRHRKEDIEREVNAKYL-DLDELLEEVDIVILALPL 210
+G+G IG+ + +R K FG I + + +++ + + + D++EL + D + L +PL
Sbjct: 145 IGLGRIGQQVVKRAKAFGMNIIGYDPYIPKEVAESMGVELVDDINELCKRADFITLHVPL 204
Query: 211 TKETYHIINEERVKKL-EGKYLVNIGRGALIDEKALVKAIKEGKLKGFATDVFEEEPVKE 269
T +T HII E++ + + +VN RG LIDEKAL +A+KEGK++ A DVFEEEP K+
Sbjct: 205 TPKTRHIIGREQIALMKKNAIIVNCARGGLIDEKALYEALKEGKIRAAALDVFEEEPPKD 264
Query: 270 HELFRFKWETVLTPHYAGLGKDVLEDMGFRAVENLLKVLRGEIPEDLVNKEVLKVRPIDE 329
+ L + TPH ++ + G E + KVLRGE+ E++VN + + +
Sbjct: 265 NPLLTLD-NVIGTPHQGASTEEAQKAAGTIVAEQIKKVLRGELAENVVNMPNIPQEKLGK 323
Query: 330 VK 331
+K
Sbjct: 324 LK 325
>pir||H70032 glycerate dehydrogenase homolog yvcT - Bacillus subtilis
>gi|2635981|emb|CAB15473.1| (Z99121) similar to
glycerate dehydrogenase [Bacillus subtilis]
Length = 325
Score = 195 bits (491), Expect = 5e-49
Identities = 110/293 (37%), Positives = 169/293 (57%), Gaps = 17/293 (5%)
Query: 36 LKEIIPELDGIIIAPVT--RITKDILERAERLKVISCQSAGYDHVDVEEATKRGIYVTKV 93
L E + E +G++ + + I +++LE A +LKV+S QS GYD+ D+E +RG+ T
Sbjct: 39 LFEKLKEAEGLLTSGTSGPSINRELLEHAPKLKVVSNQSVGYDNFDIEAMKERGVVGTHT 98
Query: 94 SGLLSEAVAEFALGLLISLMRKIHYADSFIREGKWESHTFVWREFKEVETLYGKEV---- 149
L + VA+ A L++S R++ D F+R GKW + E E L+G +V
Sbjct: 99 PYTLDDTVADLAFSLILSSARRVAELDRFVRAGKWGT--------VEEEALFGIDVHHQT 150
Query: 150 -GIVGMGAIGKAIARRLK-PFGCEIYYWSRHRKEDIEREVNAKYLDLDELLEEVDIVILA 207
GI+GMG IG+ ARR K F E+ Y +RHRK++ E + KY +LD LLE+ D ++L
Sbjct: 151 LGIIGMGRIGEQAARRAKFGFDMEVLYHNRHRKQETEDSIGVKYAELDTLLEQSDFILLI 210
Query: 208 LPLTKETYHIINEERVKKLEGKYL-VNIGRGALIDEKALVKAIKEGKLKGFATDVFEEEP 266
PLT ETYH+I E K ++ + VNI RG +DEKAL++A++EG ++G DV+E+EP
Sbjct: 211 TPLTDETYHMIGEREFKLMKNSAIFVNISRGKTVDEKALIRALQEGWIRGAGLDVYEKEP 270
Query: 267 VKEHELFRFKWETVLTPHYAGLGKDVLEDMGFRAVENLLKVLRGEIPEDLVNK 319
V + L PH V +M +A EN+L ++G+ P++L +
Sbjct: 271 VTQDNPLLQLDNVTLLPHIGSATAKVRFNMCKQAAENMLAAIQGQTPKNLTRE 323
>emb|CAB08066.1| (Z94043) hypothetical protein [Bacillus subtilis]
Length = 288
Score = 195 bits (491), Expect = 5e-49
Identities = 110/293 (37%), Positives = 169/293 (57%), Gaps = 17/293 (5%)
Query: 36 LKEIIPELDGIIIAPVT--RITKDILERAERLKVISCQSAGYDHVDVEEATKRGIYVTKV 93
L E + E +G++ + + I +++LE A +LKV+S QS GYD+ D+E +RG+ T
Sbjct: 2 LFEKLKEAEGLLTSGTSGPSINRELLEHAPKLKVVSNQSVGYDNFDIEAMKERGVVGTHT 61
Query: 94 SGLLSEAVAEFALGLLISLMRKIHYADSFIREGKWESHTFVWREFKEVETLYGKEV---- 149
L + VA+ A L++S R++ D F+R GKW + E E L+G +V
Sbjct: 62 PYTLDDTVADLAFSLILSSARRVAELDRFVRAGKWGT--------VEEEALFGIDVHHQT 113
Query: 150 -GIVGMGAIGKAIARRLK-PFGCEIYYWSRHRKEDIEREVNAKYLDLDELLEEVDIVILA 207
GI+GMG IG+ ARR K F E+ Y +RHRK++ E + KY +LD LLE+ D ++L
Sbjct: 114 LGIIGMGRIGEQAARRAKFGFDMEVLYHNRHRKQETEDSIGVKYAELDTLLEQSDFILLI 173
Query: 208 LPLTKETYHIINEERVKKLEGKYL-VNIGRGALIDEKALVKAIKEGKLKGFATDVFEEEP 266
PLT ETYH+I E K ++ + VNI RG +DEKAL++A++EG ++G DV+E+EP
Sbjct: 174 TPLTDETYHMIGEREFKLMKNSAIFVNISRGKTVDEKALIRALQEGWIRGAGLDVYEKEP 233
Query: 267 VKEHELFRFKWETVLTPHYAGLGKDVLEDMGFRAVENLLKVLRGEIPEDLVNK 319
V + L PH V +M +A EN+L ++G+ P++L +
Sbjct: 234 VTQDNPLLQLDNVTLLPHIGSATAKVRFNMCKQAAENMLAAIQGQTPKNLTRE 286
>dbj|BAB07033.1| (AP001518) glycerate dehydrogenase [Bacillus halodurans]
Length = 324
Score = 190 bits (478), Expect = 2e-47
Identities = 108/298 (36%), Positives = 168/298 (56%), Gaps = 9/298 (3%)
Query: 29 PYPSEEELKEIIPELDGIIIAPVTRITKDILERAERLKVISCQSAGYDHVDVEEATKRGI 88
P P E LKE+ E DG+ R + ERA+RLKV+S + GYD++D++EATKRG+
Sbjct: 32 PMPRELFLKEL-EEADGVFTNLTDRFDVEAFERAKRLKVVSTMAVGYDNIDIKEATKRGV 90
Query: 89 YVTKVSGLLSEAVAEFALGLLISLMRKIHYADSFIREGKWESHTFVWREFKEV-ETLYGK 147
V G+L+EA A+ LL++ R++ + ++R +W+S W F + +YG
Sbjct: 91 SVGHTPGVLTEATADLTFALLMATGRRLRESIDYVRNDQWKS----WGPFMLTGQAIYGT 146
Query: 148 EVGIVGMGAIGKAIARRLKPFGCEIYYWSRHRKEDIEREVNAKYLDLDELLEEVDIVILA 207
+GI+GMG IG+A+A+R K F + Y +R R E E+E+ A Y LD LL D V+L
Sbjct: 147 TLGIIGMGRIGQAVAKRAKGFNMTLLYHNRSRNEQAEKELGATYCSLDHLLARSDYVVLL 206
Query: 208 LPLTKETYHIINEERVKKLEG-KYLVNIGRGALIDEKALVKAIKEGKLKGFATDVFEEEP 266
P T ET ++ + +K++ + +N RG +DE+AL +A+ EG + G DV+E+EP
Sbjct: 207 APSTDETRKMMGPAQFQKMKSTAHFINTSRGTNVDEQALYRALTEGWIAGAGLDVYEKEP 266
Query: 267 VK-EHELFRFKWETVLTPHYAGLGKDVLEDMGFRAVENLLKVLRGEIPEDLVNKEVLK 323
+ +H L + V PH +M A+ENLL ++G+ + N EVL+
Sbjct: 267 ISADHPLVQLP-NVVALPHIGSAEVGTRREMVRLAIENLLLGIKGKSLTHIANPEVLE 323
>pir||A70464 D-3-phosphoglycerate dehydrogenase - Aquifex aeolicus
>gi|2984165|gb|AAC07698.1| (AE000762)
D-3-phosphoglycerate dehydrogenase [Aquifex aeolicus]
Length = 533
Score = 181 bits (454), Expect = 1e-44
Identities = 106/302 (35%), Positives = 170/302 (56%), Gaps = 13/302 (4%)
Query: 24 DVVLKPYPSEEELKEIIPELDGIIIAPVTRITKDILERAERLKVISCQSAGYDHVDVEEA 83
+V +P S EEL EII + D II T +TK++LERAE+LKV+ G D+VD+EEA
Sbjct: 25 EVYNEPDISYEELLEIIKDFDAIITRSRTPVTKELLERAEKLKVVGRAGVGVDNVDIEEA 84
Query: 84 TKRGIYVTKVSGLLSEAVAEFALGLLISLMRKIHYADSFIREGKWESHTFVWREFKEVET 143
TKRGI V G + E + ++++MR H A + KW+ F+ E
Sbjct: 85 TKRGILVVNTPGANTIGATELTMMHMLTIMRNGHKAHESMLNYKWDRKKFMGEE------ 138
Query: 144 LYGKEVGIVGMGAIGKAIARRLKPFGCEIYYWSRHRKEDIEREVNAKYLD-LDELLEEVD 202
LYG+ +GI+G+G IG +A R K FG ++ + + + ++ K +D L ++L E+D
Sbjct: 139 LYGRILGIIGLGNIGSQVAIRAKAFGMKVMAYDPYIPREKAEKLGVKLVDNLHDMLREID 198
Query: 203 IVILALPLTKETYHIINEERVKKL-EGKYLVNIGRGALIDEKALVKAIKEGKLKGFATDV 261
++ + PLT ET ++I+E+ + + +G Y+VN RG +I+EKAL+K ++ GK+KG A DV
Sbjct: 199 VLTIHAPLTHETKNMIDEKEFEIMKDGVYIVNCARGGIINEKALIKYMESGKIKGVALDV 258
Query: 262 FEEEP-----VKEHELFRFKWETVLTPHYAGLGKDVLEDMGFRAVENLLKVLRGEIPEDL 316
+ +EP + E + K L+PH + ++ + +LK L+G+ E
Sbjct: 259 YSKEPPPPEFIDELKRLADKVNISLSPHIGANTYESQRNVAVIVAQQVLKALKGQTVEYA 318
Query: 317 VN 318
VN
Sbjct: 319 VN 320
>gb|AAF79644.1|AC025416_18 (AC025416) F5O11.29 [Arabidopsis thaliana]
>gi|9502370|gb|AAF88077.1|AC025417_5 (AC025417) T12C24.9
[Arabidopsis thaliana]
Length = 323
Score = 178 bits (446), Expect = 1e-43
Identities = 105/279 (37%), Positives = 156/279 (55%), Gaps = 15/279 (5%)
Query: 32 SEEELKEIIPE----LDGIIIAPVTRITKDILERAERLKVISCQSAGYDHVDVEEATKRG 87
S E L P +I+ +T ++L L+++ C S G DH+D+ +RG
Sbjct: 38 SSESLPSFFPRHASSARAFVISGRLPVTDELLSHLPSLQILVCTSVGIDHIDLAACKRRG 97
Query: 88 IYVTKVSGLLSEAVAEFALGLLISLMRKIHYADSFIREGKWESHTFVWREFKEVETLYGK 147
I +T S+ VA+ A+GLLIS++R+I AD ++R G W + +F+ + GK
Sbjct: 98 IVITNAGNAFSDDVADCAVGLLISVLRRIPAADRYVRSGNWAK----FGDFQLGSKVSGK 153
Query: 148 EVGIVGMGAIGKAIARRLKPFGCEIYYWSRHRKEDIEREVNAKYLDLDELLEEVDIVILA 207
VGIVG+G+IG +A+RL+ FGC I Y SR +K+ Y D+ L E D+++L
Sbjct: 154 RVGIVGLGSIGSFVAKRLESFGCVISYNSRSQKQSSPYRY---YSDILSLAENNDVLVLC 210
Query: 208 LPLTKETYHIINEERVKKLEGK--YLVNIGRGALIDEKALVKAIKEGKLKGFATDVFEEE 265
LT ET+HI+N E V +L GK ++N+GRG LIDEK +VK + +G + G DVFE E
Sbjct: 211 CSLTDETHHIVNRE-VMELLGKDGVVINVGRGKLIDEKEMVKCLVDGVIGGAGLDVFENE 269
Query: 266 PVKEHELFRFKWETVLTPHYAGLGKDVLEDMGFRAVENL 304
P ELF VL+PH+A L+++ A+ NL
Sbjct: 270 PAVPQELFGLD-NVVLSPHFAVATPGSLDNVAQIALANL 307
>pir||C83158 probable 2-hydroxyacid dehydrogenase PA3896 [imported] -
Pseudomonas aeruginosa (strain PAO1)
>gi|9950078|gb|AAG07283.1|AE004807_2 (AE004807) probable
2-hydroxyacid dehydrogenase [Pseudomonas aeruginosa]
Length = 325
Score = 177 bits (445), Expect = 1e-43
Identities = 113/326 (34%), Positives = 184/326 (55%), Gaps = 10/326 (3%)
Query: 1 MKPRIGVLFKMKSKPLEELKKYTDV-VLKPYPSEEELK--EIIPELDGIIIAPVTRITKD 57
MK + V ++ + LE L+ +V VL+P + + + +P+ G+I +
Sbjct: 1 MKKNVFVFSRLAPEHLERLQCQFNVRVLEPKQGDIDAQYAAALPDTHGMIGVGRPLGARQ 60
Query: 58 ILERAERLKVISCQSAGYDHVDVEEATKRGIYVTKVSGLLSEAVAEFALGLLISLMRKIH 117
LE+A++L+VIS S GYD+ D++ +RGI +T +L+E A+ LLIS R++
Sbjct: 61 -LEQAKQLEVISSVSVGYDNYDLDYLNRRGIALTNTPDVLTETTADLGFALLISAARRVA 119
Query: 118 YADSFIREGKWESHTFVWREFKEVETLYGKEVGIVGMGAIGKAIARRLK-PFGCEIYYWS 176
D++++ G W+ T +F ++GK++GI+G+G IG AIARR + FG ++ Y
Sbjct: 120 ELDAWVKAGNWK-RTVDAPQFG--TDVHGKKLGILGLGRIGAAIARRGRFGFGMQVLYHG 176
Query: 177 RHRKEDIEREVNAKYLDLDELLEEVDIVILALPLTKETYHIINEERVKKLE-GKYLVNIG 235
+RK ++E+E+ A++L DELL E D V + +PL +T +I + ++ LVN+
Sbjct: 177 NNRKPELEQELGARFLGFDELLGEADFVCVVVPLGAQTRQLIGARELGLMKPSAILVNVA 236
Query: 236 RGALIDEKALVKAIKEGKLKGFATDVFEEEPVKEHELFRFKWETVLTPHYAGLGKDVLED 295
RG ++DE ALV A++E ++ G DV+E+EP+ E LF V PH +
Sbjct: 237 RGQVVDEAALVAALREKRILGAGLDVYEKEPLAESPLFALD-NVVTLPHIGSATHETRRA 295
Query: 296 MGFRAVENLLKVLRGEIPEDLVNKEV 321
M RA++N LRGE P DLVN +V
Sbjct: 296 MAERALQNFEAALRGERPLDLVNPQV 321
>gi|11499368 2-hydroxyacid dehydrogenase, putative [Archaeoglobus fulgidus]
>gi|7431350|pir||B69472 2-hydroxyacid dehydrogenase
homolog - Archaeoglobus fulgidus
>gi|2648765|gb|AAB89467.1| (AE000979) 2-hydroxyacid
dehydrogenase, putative [Archaeoglobus fulgidus]
Length = 323
Score = 176 bits (443), Expect = 2e-43
Identities = 112/300 (37%), Positives = 173/300 (57%), Gaps = 11/300 (3%)
Query: 25 VVLKPYPSEEELKEIIPELDGIIIAPVT---RITKDILERAERLKVISCQSAGYDHVDVE 81
VV+ Y E + E + + D I+I T IT++++ E++K+I S GY+++DVE
Sbjct: 30 VVIGEY-DERRILEAVRDAD-IVIGDYTFKIPITEEMMRAMEKVKLIQQPSTGYNNIDVE 87
Query: 82 EATKRGIYVTKVSGLLSEAVAEFALGLLISLMRKIHYADSFIREGKWESHTFVWREFKEV 141
A K I V V G+ + +VAE + ++L+R++ YA + + G+WE V
Sbjct: 88 AAKKLSITVANVGGVNALSVAEHTVMFALALLRRLIYAHNSVLSGRWEQDEMA---NLGV 144
Query: 142 ETLYGKEVGIVGMGAIGKAIARRLKPFGCEIYYWSRHRKEDIEREVNAKYLDLDELLEEV 201
L+GK GI+GMGA G+ + +RL+ +G +I Y R EDIE E ++ D D LL E
Sbjct: 145 YELHGKTWGIIGMGAQGREVTKRLQGWGVKIIYHDVRRAEDIE-EYGVEFRDFDALLREA 203
Query: 202 DIVILALPLTKETYHIINEERVKKLEGK-YLVNIGRGALIDEKALVKAIKEGKLKGFATD 260
DIV L +PLT+ET +I E +K ++ L+N+ RG ++DE ALV+AIKE + G A D
Sbjct: 204 DIVSLHVPLTEETRGMIGERELKMMKNSAILINVARGEVVDENALVRAIKERWIAGAALD 263
Query: 261 VFEEEPVKEHELFRFKWETVL-TPHYAGLGKDVLEDMGFRAVENLLKVLRGEIPEDLVNK 319
VF +EP + EL K V+ TPH AG + + A+EN+ + LRGE + +V++
Sbjct: 264 VFAKEPPEGSELLELKSHNVIFTPHIAGATNEARLRIIREAMENIGRALRGEEVKHVVSR 323
>pir||B72257 D-3-phosphoglycerate dehydrogenase - Thermotoga maritima (strain
MSB8) >gi|4981965|gb|AAD36472.1|AE001793_2 (AE001793)
D-3-phosphoglycerate dehydrogenase [Thermotoga maritima]
Length = 306
Score = 174 bits (436), Expect = 2e-42
Identities = 100/287 (34%), Positives = 159/287 (54%), Gaps = 14/287 (4%)
Query: 26 VLKPYPSEEELKEIIPELDGIIIAPVTRITKDILERAERLKVISCQSAGYDHVDVEEATK 85
V + ++EL +IIPE+D +++ T++T DI+E + LK+I+ G D++DV++A +
Sbjct: 28 VTSEHLEKDELMKIIPEVDVLVVRSATKVTADIIEAGKNLKIIARAGIGLDNIDVQKAKE 87
Query: 86 RGIYVTKVSGLLSEAVAEFALGLLISLMRKIHYADSFIREGKWESHTFVWREFKEVETLY 145
+GI V G + +VAE A+GL+++ R I A ++EGKWE +E L
Sbjct: 88 KGIKVLNTPGASAPSVAELAMGLMLACARHIARATVSLKEGKWEKKALKGKE------LL 141
Query: 146 GKEVGIVGMGAIGKAIARRLKPFGCEIYYWSRHRKEDIEREVNAKYLDLDELLEEVDIVI 205
GK +G++G G IG+ +A+R FG +I + + E ++ +Y+DLD L +E D +
Sbjct: 142 GKTLGLIGFGNIGQEVAKRALAFGMKIIAYDPAKP---ETDLPVEYVDLDTLFKESDFIS 198
Query: 206 LALPLTKETYHIINEERVKKL-EGKYLVNIGRGALIDEKALVKAIKEGKLKGFATDVFEE 264
L +PLT+ T HIIN E + K+ +G +VN RG IDE+AL + + GK+ DVFE
Sbjct: 199 LHVPLTESTRHIINRESIAKMKDGVIIVNTARGGTIDEEALYEEVVSGKVYAAGLDVFEV 258
Query: 265 EPVKE---HELFRFKWETVLTPHYAGLGKDVLEDMGFRAVENLLKVL 308
EP + +L V TPH + +G VE + K L
Sbjct: 259 EPPTDEIRRKLLSLD-NVVATPHIGASTAEAQRRVGIELVEKIFKEL 304
>gb|AAD21956.1| (AF101234) unknown [Staphylococcus aureus]
Length = 319
Score = 174 bits (436), Expect = 2e-42
Identities = 103/321 (32%), Positives = 166/321 (51%), Gaps = 10/321 (3%)
Query: 4 RIGVLFKMKSKPLEELKKYTDVV-----LKPYPSEEELKEIIPELDGIIIAPVTRITKDI 58
+I V K+ K ++L K DVV L P P +++ + + D I +I +I
Sbjct: 3 KIVVSRKIPDKFYQQLSKLGDVVMWQKSLVPMP-KDQFVTALRDADACFITLSEQIDAEI 61
Query: 59 LERAERLKVISCQSAGYDHVDVEEATKRGIYVTKVSGLLSEAVAEFALGLLISLMRKIHY 118
L ++ LKVI+ + GYD++DVE AT + VT +L+E AE L++++ R+I
Sbjct: 62 LAQSPNLKVIANMAVGYDNIDVESATANNVVVTNTPNVLTETTAELGFTLMLAIARRIVE 121
Query: 119 ADSFIREGKWESHTFVWREFKEVETLYGKEVGIVGMGAIGKAIARRLKPFGCEIYYWSRH 178
A+ ++ W+S K+V + +GI GMG IGKA ARRL+ F I Y +R
Sbjct: 122 AEKYVEADAWQSWGPYLLSGKDV---FNSTIGIYGMGDIGKAFARRLQGFNTNILYHNRS 178
Query: 179 RKEDIEREVNAKYLDLDELLEEVDIVILALPLTKETYHIINEERVKKLEGKYL-VNIGRG 237
R +D E + NA Y+ + LL E D +I PLTKET+H N E ++++ + +NIGRG
Sbjct: 179 RHKDAEADFNATYVSFETLLAESDFIICTAPLTKETHHKFNAEAFEQMKNDAIFINIGRG 238
Query: 238 ALIDEKALVKAIKEGKLKGFATDVFEEEPVKEHELFRFKWETVLTPHYAGLGKDVLEDMG 297
++DE AL+ A+ ++ DV EP+ + ++TPH ++M
Sbjct: 239 QIVDETALIDALDNKEILACGLDVLANEPIDHTHPLMGRDNVLITPHIGSASVTTRDNMI 298
Query: 298 FRAVENLLKVLRGEIPEDLVN 318
+ N+ V+ ++P VN
Sbjct: 299 QLCINNIEAVMTNQVPHTPVN 319
>pir||C72483 probable formate dehydrogenase APE2507 - Aeropyrum pernix (strain
K1) >gi|5106212|dbj|BAA81523.1| (AP000064) 326aa long
hypothetical formate dehydrogenase [Aeropyrum pernix]
Length = 326
Score = 170 bits (427), Expect = 2e-41
Identities = 104/299 (34%), Positives = 165/299 (54%), Gaps = 18/299 (6%)
Query: 31 PSEEELKEIIPELDGIIIAPVT---RITKDILERAERLKVISCQSAGYDHVDVEEATKRG 87
P E L+E+ ++I T RI ++ ER++++ S GYDH+DVE + G
Sbjct: 32 PRERVLEELRDA--DVVIGDYTFQMRIDAEMCAAMERVRLVQQPSTGYDHIDVEACARHG 89
Query: 88 IYVTKVSGLLSEAVAEFALGLLISLMRKIHYADSFIREGKWESHTFVWREFKEVET--LY 145
+ V G + +VAE+ + ++L++++ YA G W WR E+ T L
Sbjct: 90 VPVANAGGANAVSVAEYTIMAALALLKRLLYAHRETVAGGWPQ----WR-LMEMGTFDLQ 144
Query: 146 GKEVGIVGMGAIGKAIARRLKPFGCEIYYWSRHRKEDIEREVNAKYLDLDELLEEVDIVI 205
GK GI+G+G IG+ +A+RL+PF Y+ + R ED ERE+ +Y L LL E D+V
Sbjct: 145 GKTWGIIGLGRIGREVAKRLRPFEVRTVYFDKVRMEDAERELGVEYRSLSRLLRESDVVS 204
Query: 206 LALPLTKETYHIINEERVKKLE-GKYLVNIGRGALIDEKALVKAIKEGKLKGFATDVFEE 264
+ +PLT ET +I E ++ ++ L+N RG ++DE+AL +A++E + G A DV+
Sbjct: 205 IHVPLTSETRGMIGEGELRMMKPTAVLINPSRGEIVDEEALARAVRERWIAGAAVDVYSR 264
Query: 265 E-PVKEHELFRFKWET----VLTPHYAGLGKDVLEDMGFRAVENLLKVLRGEIPEDLVN 318
E P +H L R E +LTPH AG D + ++EN+++VL+G PE +VN
Sbjct: 265 EPPPPDHPLIRAAGEADVNLILTPHIAGANTDARSRIIQFSIENIVRVLKGGKPEAVVN 323
>sp|O04130|SERA_ARATH D-3-PHOSPHOGLYCERATE DEHYDROGENASE PRECURSOR (PGDH)
>gi|2189964|dbj|BAA20405.1| (AB003280) Phosphoglycerate
dehydrogenase [Arabidopsis thaliana]
>gi|2804258|dbj|BAA24440.1| (AB010407) phosphoglycerate
dehydrogenase [Arabidopsis thaliana]
>gi|9802747|gb|AAF99816.1|AC034257_8 (AC034257)
D-3-phosphoglycerate dehydrogenase [Arabidopsis
thaliana]
Length = 624
Score = 169 bits (423), Expect = 5e-41
Identities = 107/332 (32%), Positives = 170/332 (50%), Gaps = 10/332 (3%)
Query: 2 KPRIGVLFKMKSKPLEELKKYTDVVLKPYPSEEELKEIIPELDGIIIAPVTRITKDILER 61
KPRI V K+ + L+++ DV S E+LK+ + E D +I+ T++T+++ E
Sbjct: 82 KPRILVTEKLGEAGVNLLREFGDVDCSYDLSPEDLKKKVAESDALIVRSGTKVTREVFEA 141
Query: 62 AE-RLKVISCQSAGYDHVDVEEATKRGIYVTKVSGLLSEAVAEFALGLLISLMRKIHYAD 120
A+ RLKV+ G D+VD++ AT+ G V + A AE + LL S+ R + AD
Sbjct: 142 AKGRLKVVGRAGVGIDNVDLQAATEHGCLVVNAPTANTVAAAEHGIALLASMARNVAQAD 201
Query: 121 SFIREGKWESHTFVWREFKEVETLYGKEVGIVGMGAIGKAIARRLKPFGCEIYYWSRHRK 180
+ I+ GKWE +V +L GK + ++G G +G +ARR K G + +
Sbjct: 202 ASIKAGKWERSKYVG------VSLVGKTLAVMGFGKVGTEVARRAKGLGMTVISHDPYAP 255
Query: 181 EDIEREVNAKYLDLDELLEEVDIVILALPLTKETYHIINEERVKKLE-GKYLVNIGRGAL 239
D R + + D+ + D V L +PLT T + N+E K++ G L+N+ RG +
Sbjct: 256 ADRARALGVDLVSFDQAISTADFVSLHMPLTPATKKVFNDETFSKMKKGVRLINVARGGV 315
Query: 240 IDEKALVKAIKEGKLKGFATDVF-EEEPVKEHELFRFKWETVLTPHYAGLGKDVLEDMGF 298
IDE ALV+A+ G + A DVF EE P K+ L + + TV TPH K+ E +
Sbjct: 316 IDEDALVRALDAGIVAQAALDVFCEEPPSKDSRLIQHENVTV-TPHLGASTKEAQEGVAI 374
Query: 299 RAVENLLKVLRGEIPEDLVNKEVLKVRPIDEV 330
E + L+GE+ VN ++ + E+
Sbjct: 375 EIAEAVAGALKGELSATAVNAPMVAPEVLSEL 406
>pir||F83362 probable 2-hydroxyacid dehydrogenase PA2263 [imported] -
Pseudomonas aeruginosa (strain PAO1)
>gi|9948291|gb|AAG05651.1|AE004652_4 (AE004652) probable
2-hydroxyacid dehydrogenase [Pseudomonas aeruginosa]
Length = 328
Score = 168 bits (422), Expect = 7e-41
Identities = 107/318 (33%), Positives = 171/318 (53%), Gaps = 10/318 (3%)
Query: 7 VLFKMKSKPL-EELKKYTDVVLKPYPSEE---ELKEIIPELDGIIIAPVTRITKDILERA 62
VL+K S PL E L++ +V+L P + L++ +PE G++ A + R+ +L+ A
Sbjct: 5 VLYKRLSAPLMERLRERVEVLLVEEPGRDGLARLRDALPEAHGLLGASL-RLDAGLLDLA 63
Query: 63 ERLKVISCQSAGYDHVDVEEATKRGIYVTKVSGLLSEAVAEFALGLLISLMRKIHYADSF 122
RL+ I+ S G D+ D++ +RGI ++ +L+E A+ L+++ R++ +
Sbjct: 64 PRLEAIASVSVGVDNYDIDYLDRRGILLSNTPDVLTETTADTGFALILATARRVVELAGW 123
Query: 123 IREGKWESHTFVWREFKEVETLYGKEVGIVGMGAIGKAIARR-LKPFGCEIYYWSRHRKE 181
+R G+W+ + +V +GK +GIVGMG IG+A+ARR FG + Y S K
Sbjct: 124 VRAGEWKKSVGAAQFGTDV---HGKTLGIVGMGRIGEALARRGHHGFGMRVLYHSHSPKP 180
Query: 182 DIEREVNAKYLDLDELLEEVDIVILALPLTKETYHIINEERVKKLEGKYL-VNIGRGALI 240
+E A Y LD LLEE D V L LPLT T +I + ++ + + +NI RG ++
Sbjct: 181 HVEERYAASYRPLDALLEESDFVCLTLPLTAATEGLIGAAQFARMRPQAIFINISRGRVV 240
Query: 241 DEKALVKAIKEGKLKGFATDVFEEEPVKEHELFRFKWETVLTPHYAGLGKDVLEDMGFRA 300
DE AL++A+ + +++ DVFE EP+ V TPH ++ E M A
Sbjct: 241 DEAALIEALAQRRIRAAGLDVFEREPLSPDSPLLRLPNVVATPHIGSATEETREAMARCA 300
Query: 301 VENLLKVLRGEIPEDLVN 318
V+NLL L G P +LVN
Sbjct: 301 VDNLLAALAGARPLNLVN 318
>sp|P73821|SERA_SYNY3 D-3-PHOSPHOGLYCERATE DEHYDROGENASE (PGDH) >gi|7431369|pir||S75016
phosphoglycerate dehydrogenase - Synechocystis sp.
(strain PCC 6803) >gi|1652961|dbj|BAA17878.1| (D90910)
phosphoglycerate dehydrogenase [Synechocystis sp.]
Length = 554
Score = 168 bits (421), Expect = 9e-41
Identities = 99/304 (32%), Positives = 163/304 (53%), Gaps = 8/304 (2%)
Query: 16 LEELKKYTDVVLKPYPSEEELKEIIPELDGIIIAPVTRITKDILERAERLKVISCQSAGY 75
++ LK+ V +K SE E+ +I+PE D I++ T++T+ I++ +LK+I G
Sbjct: 43 IDILKQVAQVDVKTGLSEAEIIDIVPEYDAIMLRSATKVTEKIIQAGSQLKIIGRAGVGV 102
Query: 76 DHVDVEEATKRGIYVTKVSGLLSEAVAEFALGLLISLMRKIHYADSFIREGKWESHTFVW 135
D++DV AT++GI V + A AE AL ++++L R I A+ ++E KWE F+
Sbjct: 103 DNIDVPAATRQGIVVVNSPEGNTIAAAEHALAMMMALARHIPDANKSVKESKWERKQFIG 162
Query: 136 REFKEVETLYGKEVGIVGMGAIGKAIARRLKPFGCEIYYWSRHRKEDIEREVNAKYLDLD 195
E +Y K +G+VG+G IG +A K G ++ + ++ ++ +DLD
Sbjct: 163 TE------VYKKTLGVVGLGKIGSHVAGVAKAMGMKLLAYDPFISQERADQIGCTLVDLD 216
Query: 196 ELLEEVDIVILALPLTKETYHIINEERVKKLE-GKYLVNIGRGALIDEKALVKAIKEGKL 254
L E D + L +P T ET ++IN E + K++ ++N RG +IDE+ALV AI+ ++
Sbjct: 217 LLFSEADFITLHIPKTPETANLINAETLAKMKPTARIINCSRGGIIDEEALVTAIETAQI 276
Query: 255 KGFATDVFEEEPVKEHELFRFKWETVLTPHYAGLGKDVLEDMGFRAVENLLKVLRGEIPE 314
G A DVF +EP+ E L F +LTPH ++ ++ E + VL G
Sbjct: 277 GGAALDVFAQEPLGESRLREFS-NVILTPHLGASTEEAQVNVAVDVAEQIRDVLLGLPAR 335
Query: 315 DLVN 318
VN
Sbjct: 336 SAVN 339
>gi|11498419 phosphoglycerate dehydrogenase (serA) [Archaeoglobus fulgidus]
>gi|3122861|sp|O29445|SERA_ARCFU D-3-PHOSPHOGLYCERATE
DEHYDROGENASE (PGDH) >gi|7431372|pir||E69351
phosphoglycerate dehydrogenase (serA) homolog -
Archaeoglobus fulgidus >gi|2649798|gb|AAB90429.1|
(AE001048) phosphoglycerate dehydrogenase (serA)
[Archaeoglobus fulgidus]
Length = 527
Score = 168 bits (420), Expect = 1e-40
Identities = 93/300 (31%), Positives = 161/300 (53%), Gaps = 7/300 (2%)
Query: 20 KKYTDVVLKPYPSEEELKEIIPELDGIIIAPVTRITKDILERAERLKVISCQSAGYDHVD 79
K +V +K S EEL +P+ + I++ T++ ++++ A+ LK+I G D++D
Sbjct: 19 KNGLEVEVKTGMSREELIREVPKYEAIVVRSQTKVDAEVIQAAKNLKIIGRAGVGVDNID 78
Query: 80 VEEATKRGIYVTKVSGLLSEAVAEFALGLLISLMRKIHYADSFIREGKWESHTFVWREFK 139
+ AT+RGI V G + + AE A+ L+++ RKI AD ++EGKWE F+ E
Sbjct: 79 INAATQRGIVVVNAPGGNTISTAEHAIALMLAAARKIPQADRSVKEGKWERKKFMGIE-- 136
Query: 140 EVETLYGKEVGIVGMGAIGKAIARRLKPFGCEIYYWSRHRKEDIEREVNAKYLDLDELLE 199
L GK G++G+G +G +A+R K + + ++ ++ K +D D LL
Sbjct: 137 ----LRGKTAGVIGLGRVGFEVAKRCKALEMNVLAYDPFVSKERAEQIGVKLVDFDTLLA 192
Query: 200 EVDIVILALPLTKETYHIINEERVKKL-EGKYLVNIGRGALIDEKALVKAIKEGKLKGFA 258
D++ + +P TKET +I + + +K+ +G +VN RG ++DE AL +AIK GK+ A
Sbjct: 193 SSDVITVHVPRTKETIGLIGKGQFEKMKDGVIVVNAARGGIVDEAALYEAIKAGKVAAAA 252
Query: 259 TDVFEEEPVKEHELFRFKWETVLTPHYAGLGKDVLEDMGFRAVENLLKVLRGEIPEDLVN 318
DV+E+EP V TPH A ++ ++G E+++ + +G + VN
Sbjct: 253 LDVYEKEPPSPDNPLLKLDNVVTTPHIAASTREAQLNVGMIIAEDIVNMAKGLPVRNAVN 312
>pir||T35831 probable D-3-phosphoglycerate dehydrogenase - Streptomyces
coelicolor >gi|4467266|emb|CAB37591.1| (AL035569)
probable D-3-phosphoglycerate dehydrogenase
[Streptomyces coelicolor A3(2)]
Length = 529
Score = 166 bits (417), Expect = 3e-40
Identities = 102/321 (31%), Positives = 164/321 (50%), Gaps = 20/321 (6%)
Query: 11 MKSKPL----EELKKYTDVVLKPY--------PSEEELKEIIPELDGIIIAPVTRITKDI 58
M SKP+ EEL T L P EL I ++D I++ T++ +
Sbjct: 1 MSSKPVVLIAEELSPATVDALGPDFEIRHCNGADRAELLPAIADVDAILVRSATKVDAEA 60
Query: 59 LERAERLKVISCQSAGYDHVDVEEATKRGIYVTKVSGLLSEAVAEFALGLLISLMRKIHY 118
+ A++LKV++ G D+VDV ATK G+ V AE A GL+++ R I
Sbjct: 61 VAAAKKLKVVARAGVGLDNVDVSAATKAGVMVVNAPTSNIVTAAELACGLIVATARNIPQ 120
Query: 119 ADSFIREGKWESHTFVWREFKEVETLYGKEVGIVGMGAIGKAIARRLKPFGCEIYYWSRH 178
A++ ++ G+W+ + E E K +G+VG+G IG +A+R+ FG ++ + +
Sbjct: 121 ANAALKNGEWKRSKYTGVELAE------KTLGVVGLGRIGALVAQRMSAFGMKVVAYDPY 174
Query: 179 RKEDIEREVNAKYLDLDELLEEVDIVILALPLTKETYHIINEERVKKLEGKY-LVNIGRG 237
+ ++ K L LDELLE D + + LP T ET +I +E ++K++ +VN RG
Sbjct: 175 VQPARAAQMGVKVLSLDELLEVSDFITVHLPKTPETLGLIGDEALRKVKPSVRIVNAARG 234
Query: 238 ALIDEKALVKAIKEGKLKGFATDVFEEEPVKEHELFRFKWETVLTPHYAGLGKDVLEDMG 297
++DE+AL A+KEG++ G DV+ +EP + LF F + V TPH + E G
Sbjct: 235 GIVDEEALYSALKEGRVAGAGLDVYAKEPCTDSPLFEFD-QVVATPHLGASTDEAQEKAG 293
Query: 298 FRAVENLLKVLRGEIPEDLVN 318
+++ L GE+ D VN
Sbjct: 294 IAVAKSVRLALAGELVPDAVN 314
>dbj|BAB05321.1| (AP001512) D-3-phosphoglycerate dehydrogenase [Bacillus halodurans]
Length = 540
Score = 165 bits (414), Expect = 6e-40
Identities = 94/291 (32%), Positives = 155/291 (52%), Gaps = 8/291 (2%)
Query: 42 ELDGIIIAPVTRITKDILERAERLKVISCQSAGYDHVDVEEATKRGIYVTKVSGLLSEAV 101
E D +++ T +T++++E+ LK+I+ G D++D++ ATK GI V + +
Sbjct: 55 EYDALLVRSATTVTEELMEKMSSLKIIARAGVGVDNIDIDAATKHGIVVVNAPDGNTIST 114
Query: 102 AEFALGLLISLMRKIHYADSFIREGKWESHTFVWREFKEVETLYGKEVGIVGMGAIGKAI 161
AE ++ SL+RKI A++ I+ G+W+ F E L GK +GI+G G IG I
Sbjct: 115 AEHTFAMICSLLRKIPQANASIKAGEWKRKAFQGTE------LRGKTLGIIGFGRIGSQI 168
Query: 162 ARRLKPFGCEIYYWSRHRKEDIEREVNAKYLDLDELLEEVDIVILALPLTKETYHIINEE 221
A+R K F Y + + ++ LD++L+ DI+ + PLTKET ++ +
Sbjct: 169 AKRAKAFEMTPYVFDPFLTKARAEKLGVTVASLDDVLQVADIITVHTPLTKETKGLLGMK 228
Query: 222 RV-KKLEGKYLVNIGRGALIDEKALVKAIKEGKLKGFATDVFEEEPVKEHELFRFKWETV 280
+ K +G +L+N RG +IDE+AL ++EG + G A DVFEEEPV + EL F +
Sbjct: 229 NIGKTKKGVFLINCARGGIIDEEALKHYLREGHIAGAALDVFEEEPVADEELLAFD-NVI 287
Query: 281 LTPHYAGLGKDVLEDMGFRAVENLLKVLRGEIPEDLVNKEVLKVRPIDEVK 331
TPH A K+ ++ + + +L L G + +N L ++VK
Sbjct: 288 ATPHIAASTKEAQLNVAEQVSQEVLHFLEGNPVSNSINLPTLSKEVYEKVK 338
>sp|O53243|SERA_MYCTU D-3-PHOSPHOGLYCERATE DEHYDROGENASE (PGDH) >gi|7431374|pir||G70854
probable serA protein - Mycobacterium tuberculosis
(strain H37RV) >gi|2791593|emb|CAA16081.1| (AL021287)
serA [Mycobacterium tuberculosis]
Length = 528
Score = 164 bits (411), Expect = 1e-39
Identities = 94/289 (32%), Positives = 151/289 (51%), Gaps = 8/289 (2%)
Query: 31 PSEEELKEIIPELDGIIIAPVTRITKDILERAERLKVISCQSAGYDHVDVEEATKRGIYV 90
P ++L +PE D +++ T + ++L A +LK+++ G D+VDV+ AT RG+ V
Sbjct: 32 PDRDKLLAAVPEADALLVRSATTVDAEVLAAAPKLKIVARAGVGLDNVDVDAATARGVLV 91
Query: 91 TKVSGLLSEAVAEFALGLLISLMRKIHYADSFIREGKWESHTFVWREFKEVETLYGKEVG 150
+ AE AL LL++ R+I AD+ +RE W+ +F E ++GK VG
Sbjct: 92 VNAPTSNIHSAAEHALALLLAASRQIPAADASLREHTWKRSSFSGTE------IFGKTVG 145
Query: 151 IVGMGAIGKAIARRLKPFGCEIYYWSRHRKEDIEREVNAKYLDLDELLEEVDIVILALPL 210
+VG+G IG+ +A+R+ FG + + + ++ + L LD+LL D + + LP
Sbjct: 146 VVGLGRIGQLVAQRIAAFGAYVVAYDPYVSPARAAQLGIELLSLDDLLARADFISVHLPK 205
Query: 211 TKETYHIINEERVKKLE-GKYLVNIGRGALIDEKALVKAIKEGKLKGFATDVFEEEPVKE 269
T ET +I++E + K + G +VN RG L+DE AL AI G ++ DVF EP +
Sbjct: 206 TPETAGLIDKEALAKTKPGVIIVNAARGGLVDEAALADAITGGHVRAAGLDVFATEPCTD 265
Query: 270 HELFRFKWETVLTPHYAGLGKDVLEDMGFRAVENLLKVLRGEIPEDLVN 318
LF + V+TPH + + G E++ L GE D VN
Sbjct: 266 SPLFELA-QVVVTPHLGASTAEAQDRAGTDVAESVRLALAGEFVPDAVN 313
>gb|AAF09059.1|AC011717_26 (AC011717) putative D-isomer specific 2-hydroxyacid dehydrogenase;
59386-58329 [Arabidopsis thaliana]
Length = 313
Score = 164 bits (411), Expect = 1e-39
Identities = 93/241 (38%), Positives = 143/241 (58%), Gaps = 10/241 (4%)
Query: 65 LKVISCQSAGYDHVDVEEATKRGIYVTKVSGLLSEAVAEFALGLLISLMRKIHYADSFIR 124
L+++S S G D +D+ + ++GI VT +L+E VA+ A+GL+++L+R++ D ++R
Sbjct: 68 LEIVSSFSVGLDKIDLGKCKEKGIRVTNTPDVLTEDVADLAIGLILALLRRLCECDRYVR 127
Query: 125 EGKWESHTFVWREFKEVETLYGKEVGIVGMGAIGKAIARRLKPFGCEIYYWSRHRKEDIE 184
GKW+ EF+ GK VGI+G+G IG AIA+R + F C I Y+SR K D+
Sbjct: 128 SGKWKQ-----GEFQLTTKFSGKSVGIIGLGRIGTAIAKRAEAFSCPINYYSRTIKPDVA 182
Query: 185 REVNAKYLDLDELLEEVDIVILALPLTKETYHIINEERVKKLEGK-YLVNIGRGALIDEK 243
+ Y + +L + DI+++A PLT++T HI++ + + L K L+NIGRG +DE+
Sbjct: 183 YKY---YPTVVDLAQNSDILVVACPLTEQTRHIVDRQVMDALGAKGVLINIGRGPHVDEQ 239
Query: 244 ALVKAIKEGKLKGFATDVFEEEPVKEHELFRFKWETVLTPHYAGLGKDVLEDMGFRAVEN 303
L+KA+ EG+L G A DVFE+EP ELF + VL PH + M V N
Sbjct: 240 ELIKALTEGRLGGAALDVFEQEPHVPEELFGLE-NVVLLPHVGSGTVETRNAMADLVVGN 298
Query: 304 L 304
L
Sbjct: 299 L 299
>pir||T00876 hypothetical protein F17K2.16 - Arabidopsis thaliana
>gi|2979553|gb|AAC06162.1| (AC003680) putative glycerate
dehydrogenase [Arabidopsis thaliana]
Length = 327
Score = 163 bits (409), Expect = 2e-39
Identities = 110/304 (36%), Positives = 169/304 (55%), Gaps = 24/304 (7%)
Query: 26 VLKPYPSEEELKEIIP-ELDGI--IIAPVTR-ITKDILERAERLKVISCQSAGYDHVDVE 81
+LK + S L E + D I IIAPV +T D++ L+++ SAG DHVD+
Sbjct: 37 ILKAFESPLPLPEFLAYHSDSISAIIAPVAAPVTADLIRILPNLRLVVTTSAGVDHVDLV 96
Query: 82 EATKRGIYVTKVSGLLSEAVAEFALGLLISLMRKIHYADSFIREGKWESHTFVWREFKEV 141
E +RGI V SE VA+ A+GLLI + R+I A+ F+++ W + ++
Sbjct: 97 ECRRRGISVANAGSSFSEDVADTAVGLLIDVFRRISAANRFVKQRFWP----LKGDYPLG 152
Query: 142 ETLYGKEVGIVGMGAIGKAIARRLKPFGCEIYYWSRHRKE-DIEREVNAKYLDLDELLEE 200
L K +GIVG+G+IG +A RL FGC+I Y SR+RK D+ Y+D++E+
Sbjct: 153 SKLGRKRIGIVGLGSIGSKVATRLDAFGCQISYSSRNRKPYDVPYHY---YMDIEEMAAN 209
Query: 201 VDIVILALPLTKETYHIINEERVKKLEGK--YLVNIGRGALIDEKALVKAIKEGKLKGFA 258
D +I+ L ++T +IN++ + L GK +VN+ RGA+IDE+ +V+ ++EG++ G
Sbjct: 210 SDALIICCELNEKTLRLINKDVLSAL-GKRGVIVNVARGAIIDEEEMVRCLREGEIGGAG 268
Query: 259 TDVFEEEPVKEHELFRFKWETVLTPHYAGLGKDVLEDMGFRAVENLLKVLRGEIPEDLVN 318
DVFE+EP ELF V +PH A + + LE++G KV+ G I N
Sbjct: 269 LDVFEDEPNVPKELFELD-NVVFSPHSAFMTLEGLEELG--------KVVVGNIEAFFSN 319
Query: 319 KEVL 322
K +L
Sbjct: 320 KPLL 323
>sp|O33116|SERA_MYCLE D-3-PHOSPHOGLYCERATE DEHYDROGENASE (PGDH) >gi|11251649|pir||T45418
phosphoglycerate dehydrogenase [imported] -
Mycobacterium leprae >gi|2414551|emb|CAB16440.1|
(Z99263) phosphoglycerate dehydrogenase [Mycobacterium
leprae]
Length = 528
Score = 159 bits (398), Expect = 4e-38
Identities = 94/317 (29%), Positives = 157/317 (48%), Gaps = 8/317 (2%)
Query: 3 PRIGVLFKMKSKPLEELKKYTDVVLKPYPSEEELKEIIPELDGIIIAPVTRITKDILERA 62
P + + K+ + L +V P +L +PE D +++ T + ++L A
Sbjct: 4 PVVLIADKLAQSTVAALGDQVEVRWVDGPDRTKLLAAVPEADALLVRSATTVDAEVLAAA 63
Query: 63 ERLKVISCQSAGYDHVDVEEATKRGIYVTKVSGLLSEAVAEFALGLLISLMRKIHYADSF 122
+LK+++ G D+VDV+ AT RG+ V + AE AL LL++ R+I AD+
Sbjct: 64 PKLKIVARAGVGLDNVDVDAATARGVLVVNAPTSNIHSAAEHALALLLAASRQIAEADAS 123
Query: 123 IREGKWESHTFVWREFKEVETLYGKEVGIVGMGAIGKAIARRLKPFGCEIYYWSRHRKED 182
+R W+ +F E ++GK VG+VG+G IG+ +A R+ FG + + +
Sbjct: 124 LRAHIWKRSSFSGTE------IFGKTVGVVGLGRIGQLVAARIAAFGAHVIAYDPYVAPA 177
Query: 183 IEREVNAKYLDLDELLEEVDIVILALPLTKETYHIINEERVKKLE-GKYLVNIGRGALID 241
++ + + D+LL D + + LP T ET +I++E + K + G +VN RG L+D
Sbjct: 178 RAAQLGIELMSFDDLLARADFISVHLPKTPETAGLIDKEALAKTKPGVIIVNAARGGLVD 237
Query: 242 EKALVKAIKEGKLKGFATDVFEEEPVKEHELFRFKWETVLTPHYAGLGKDVLEDMGFRAV 301
E AL A++ G ++ DVF EP + LF + V+TPH + + G
Sbjct: 238 EVALADAVRSGHVRAAGLDVFATEPCTDSPLFELS-QVVVTPHLGASTAEAQDRAGTDVA 296
Query: 302 ENLLKVLRGEIPEDLVN 318
E++ L GE D VN
Sbjct: 297 ESVRLALAGEFVPDAVN 313
>pir||S47774 hypothetical protein o365 - Escherichia coli
>gi|466691|gb|AAB18530.1| (U00039) No definition line
found [Escherichia coli]
Length = 365
Score = 159 bits (397), Expect = 6e-38
Identities = 103/337 (30%), Positives = 174/337 (51%), Gaps = 11/337 (3%)
Query: 1 MKPRIGVLFKMKSKPLEELKKYTDVV----LKPYPSEEELKEIIPELDGIIIAPVTRITK 56
MKP + + + L+ L+++ V L P E+ I E +G++ +
Sbjct: 5 MKPSVILYKALPDDLLQRLQEHFTVHQVANLSPQTVEQNAA-IFAEAEGLL-GSNENVNA 62
Query: 57 DILERAERLKVISCQSAGYDHVDVEEATKRGIYVTKVSGLLSEAVAEFALGLLISLMRKI 116
+LE+ +L+ S S GYD+ DV+ T R I + +L+E VA+ + L++S R++
Sbjct: 63 ALLEKMPKLRATSTISVGYDNFDVDALTARKILLMHTPTVLTETVADTLMALVLSTARRV 122
Query: 117 HYADSFIREGKWESHTFVWREFKEVETLYGKEVGIVGMGAIGKAIARRLK-PFGCEIYYW 175
++ G+W + + ++ + ++ K +GIVGMG IG A+A+R F I Y
Sbjct: 123 VEVAERVKAGEWTAS--IGPDWYGTD-VHHKTLGIVGMGRIGMALAQRAHFGFNMPILYN 179
Query: 176 SRHRKEDIEREVNAKYLDLDELLEEVDIVILALPLTKETYHIINEERVKKLEGKYL-VNI 234
+R ++ E NA+Y DLD LL+E D V L LPLT ET+H+ E+ K++ + +N
Sbjct: 180 ARRHHKEAEERFNARYCDLDTLLQESDFVCLILPLTDETHHLFGAEQFAKMKSSAIFINA 239
Query: 235 GRGALIDEKALVKAIKEGKLKGFATDVFEEEPVKEHELFRFKWETVLTPHYAGLGKDVLE 294
GRG ++DE AL+ A+++G++ DVFE+EP+ V PH +
Sbjct: 240 GRGPVVDENALIAALQKGEIHAAGLDVFEQEPLSVDSPLLSMANVVAVPHIGSATHETRY 299
Query: 295 DMGFRAVENLLKVLRGEIPEDLVNKEVLKVRPIDEVK 331
M AV+NL+ L+G++ ++ VN V + VK
Sbjct: 300 GMAACAVDNLIDALQGKVEKNCVNPHVATKPRLRRVK 336
>sp|P35136|SERA_BACSU D-3-PHOSPHOGLYCERATE DEHYDROGENASE (PGDH) >gi|7427681|pir||C69705
phosphoglycerate dehydrogenase (EC 1.1.1.95) serA -
Bacillus subtilis >gi|1146196|gb|AAC83943.1| (L47648)
phosphoglycerate dehydrogenase [Bacillus subtilis]
>gi|2634742|emb|CAB14239.1| (Z99116) phosphoglycerate
dehydrogenase [Bacillus subtilis]
Length = 525
Score = 159 bits (397), Expect = 6e-38
Identities = 98/336 (29%), Positives = 172/336 (51%), Gaps = 19/336 (5%)
Query: 4 RIGVLFKMKSKPLEEL--KKYTDVVLKPYPSEEELKEIIPELDGIIIAPVTRITKDILER 61
R+ V KM + L+ L + ++V K E+ + D +++ T++T+D+ +
Sbjct: 3 RVLVSDKMSNDGLQPLIESDFIEIVQKNVADAEDE---LHTFDALLVRSATKVTEDLFNK 59
Query: 62 AERLKVISCQSAGYDHVDVEEATKRGIYVTKVSGLLSEAVAEFALGLLISLMRKIHYADS 121
LK++ G D++D++EATK G+ V + + AE ++ SLMR I A+
Sbjct: 60 MTSLKIVGRAGVGVDNIDIDEATKHGVIVINAPNGNTISTAEHTFAMISSLMRHIPQANI 119
Query: 122 FIREGKWESHTFVWREFKEVETLYGKEVGIVGMGAIGKAIARRLKPFGCEIYYWSRHRKE 181
++ +W +V E LYGK +GIVG+G IG IA+R FG ++ + E
Sbjct: 120 SVKSREWNRTAYVGSE------LYGKTLGIVGLGRIGSEIAQRRGAFGMTVHVFDPFLTE 173
Query: 182 DIEREVNAKYLDLDELLEEVDIVILALPLTKETYHIINEERVKKL-EGKYLVNIGRGALI 240
+ +++ +E+LE DI+ + PLTKET ++N+E + K +G L+N RG +I
Sbjct: 174 ERAKKIGVNSRTFEEVLESADIITVHTPLTKETKGLLNKETIAKTKKGVRLINCARGGII 233
Query: 241 DEKALVKAIKEGKLKGFATDVFEEEPVKEHELFRFKWETVLTPHYAGLGKDVLEDMGFRA 300
DE AL++A++ G + G A DVFE EP +++L + TPH K+ ++ +
Sbjct: 234 DEAALLEALENGHVAGAALDVFEVEPPVDNKLVDHPL-VIATPHLGASTKEAQLNVAAQV 292
Query: 301 VENLLKVLRGEIPEDLVN------KEVLKVRPIDEV 330
E +L+ +G +N E K++P ++
Sbjct: 293 SEEVLQFAKGLPVMSAINLPAMTKDEFAKIKPYHQI 328
>sp|P37666|YIAE_ECOLI PROBABLE 2-HYDROXYACID DEHYDROGENASE IN BISC-CSPA INTERGENIC REGION
Length = 324
Score = 158 bits (396), Expect = 7e-38
Identities = 101/327 (30%), Positives = 171/327 (51%), Gaps = 11/327 (3%)
Query: 1 MKPRIGVLFKMKSKPLEELKKYTDVV----LKPYPSEEELKEIIPELDGIIIAPVTRITK 56
MKP + + + L+ L+++ V L P E+ I E +G++ +
Sbjct: 1 MKPSVILYKALPDDLLQRLQEHFTVHQVANLSPQTVEQNAA-IFAEAEGLL-GSNENVNA 58
Query: 57 DILERAERLKVISCQSAGYDHVDVEEATKRGIYVTKVSGLLSEAVAEFALGLLISLMRKI 116
+LE+ +L+ S S GYD+ DV+ T R I + +L+E VA+ + L++S R++
Sbjct: 59 ALLEKMPKLRATSTISVGYDNFDVDALTARKILLMHTPTVLTETVADTLMALVLSTARRV 118
Query: 117 HYADSFIREGKWESHTFVWREFKEVETLYGKEVGIVGMGAIGKAIARRLK-PFGCEIYYW 175
++ G+W + + ++ + ++ K +GIVGMG IG A+A+R F I Y
Sbjct: 119 VEVAERVKAGEWTAS--IGPDWYGTD-VHHKTLGIVGMGRIGMALAQRAHFGFNMPILYN 175
Query: 176 SRHRKEDIEREVNAKYLDLDELLEEVDIVILALPLTKETYHIINEERVKKLEGKYL-VNI 234
+R ++ E NA+Y DLD LL+E D V L LPLT ET+H+ E+ K++ + +N
Sbjct: 176 ARRHHKEAEERFNARYCDLDTLLQESDFVCLILPLTDETHHLFGAEQFAKMKSSAIFINA 235
Query: 235 GRGALIDEKALVKAIKEGKLKGFATDVFEEEPVKEHELFRFKWETVLTPHYAGLGKDVLE 294
GRG ++DE AL+ A+++G++ DVFE+EP+ V PH +
Sbjct: 236 GRGPVVDENALIAALQKGEIHAAGLDVFEQEPLSVDSPLLSMANVVAVPHIGSATHETRY 295
Query: 295 DMGFRAVENLLKVLRGEIPEDLVNKEV 321
M AV+NL+ L+G++ ++ VN V
Sbjct: 296 GMAACAVDNLIDALQGKVEKNCVNPHV 322
>pir||C65154 probable 2-hydroxyacid dehydrogenase in bisC-cspA intergenic region
- Escherichia coli (strain K-12)
>gi|2367243|gb|AAC76577.1| (AE000432) putative
dehydrogenase [Escherichia coli K12]
Length = 328
Score = 158 bits (396), Expect = 7e-38
Identities = 101/327 (30%), Positives = 171/327 (51%), Gaps = 11/327 (3%)
Query: 1 MKPRIGVLFKMKSKPLEELKKYTDVV----LKPYPSEEELKEIIPELDGIIIAPVTRITK 56
MKP + + + L+ L+++ V L P E+ I E +G++ +
Sbjct: 5 MKPSVILYKALPDDLLQRLQEHFTVHQVANLSPQTVEQNAA-IFAEAEGLL-GSNENVNA 62
Query: 57 DILERAERLKVISCQSAGYDHVDVEEATKRGIYVTKVSGLLSEAVAEFALGLLISLMRKI 116
+LE+ +L+ S S GYD+ DV+ T R I + +L+E VA+ + L++S R++
Sbjct: 63 ALLEKMPKLRATSTISVGYDNFDVDALTARKILLMHTPTVLTETVADTLMALVLSTARRV 122
Query: 117 HYADSFIREGKWESHTFVWREFKEVETLYGKEVGIVGMGAIGKAIARRLK-PFGCEIYYW 175
++ G+W + + ++ + ++ K +GIVGMG IG A+A+R F I Y
Sbjct: 123 VEVAERVKAGEWTAS--IGPDWYGTD-VHHKTLGIVGMGRIGMALAQRAHFGFNMPILYN 179
Query: 176 SRHRKEDIEREVNAKYLDLDELLEEVDIVILALPLTKETYHIINEERVKKLEGKYL-VNI 234
+R ++ E NA+Y DLD LL+E D V L LPLT ET+H+ E+ K++ + +N
Sbjct: 180 ARRHHKEAEERFNARYCDLDTLLQESDFVCLILPLTDETHHLFGAEQFAKMKSSAIFINA 239
Query: 235 GRGALIDEKALVKAIKEGKLKGFATDVFEEEPVKEHELFRFKWETVLTPHYAGLGKDVLE 294
GRG ++DE AL+ A+++G++ DVFE+EP+ V PH +
Sbjct: 240 GRGPVVDENALIAALQKGEIHAAGLDVFEQEPLSVDSPLLSMANVVAVPHIGSATHETRY 299
Query: 295 DMGFRAVENLLKVLRGEIPEDLVNKEV 321
M AV+NL+ L+G++ ++ VN V
Sbjct: 300 GMAACAVDNLIDALQGKVEKNCVNPHV 326
>pir||A72390 hypothetical protein TM0327 - Thermotoga maritima (strain MSB8)
>gi|4980828|gb|AAD35414.1|AE001714_5 (AE001714)
phosphoglycerate dehydrogenase, putative [Thermotoga
maritima]
Length = 327
Score = 156 bits (390), Expect = 4e-37
Identities = 98/318 (30%), Positives = 175/318 (54%), Gaps = 16/318 (5%)
Query: 10 KMKSKPLEELKKYTDVVLKPYPSEEELKEIIPELDGIIIAPVTRITKDILERAERLKVIS 69
K +P+E L+K +++ S+ +I+ E+D +I+ +T +++E + LK+I+
Sbjct: 13 KYSQEPVEFLRKEGFEIIR---SDTIDPDILKEVDALIVG-THPVTAEMVENSS-LKIIA 67
Query: 70 CQSAGYDHVDVEEATKRGIYVTKVSGLLSEAVAEFALGLLISLMRKIHYA-DSFIREGKW 128
G D++D+E ATK+GI VT +G S +VAE + + +L R + +A + E +W
Sbjct: 68 KHGVGVDNIDLEAATKKGIPVTITAGANSLSVAELTIAFIFALSRGLVWAHNKLFLERRW 127
Query: 129 ESHTFVWREFKEVETLYGKEVGIVGMGAIGKAIARRLKPFGCEIYYWSRHRKEDIEREVN 188
E + + GK +G+VG G+IG+ + ++ G + + + +D R +
Sbjct: 128 EGTVG--------QEVSGKTLGVVGFGSIGREVVKKAVCLGMNVLVYDPYVSKDSVRLLE 179
Query: 189 AKYLD-LDELLEEVDIVILALPLTKETYHIINEERVKKLE-GKYLVNIGRGALIDEKALV 246
A +D L++LL+E D V L +PL + T ++I E + ++ +L+N RG L+DE+ALV
Sbjct: 180 ATPVDDLEQLLKESDFVSLHVPLNESTKNMIGERELSLMKKSAFLINTSRGELVDEEALV 239
Query: 247 KAIKEGKLKGFATDVFEEEPVKEHELFRFKWETVLTPHYAGLGKDVLEDMGFRAVENLLK 306
KA+KEG++ G A DVF EEP + + T H K+ + M A ++++
Sbjct: 240 KALKEGRIAGAALDVFSEEPPDANSPLFECPNLITTAHIGAHTKEAIFRMNMMAAQSIVD 299
Query: 307 VLRGEIPEDLVNKEVLKV 324
+G IP +VNKEV+++
Sbjct: 300 FFKGRIPRYVVNKEVIRI 317
>pir||T51423 formate dehydrogenase (FDH) - Arabidopsis thaliana
>gi|6625953|gb|AAF19435.1|AF208028_1 (AF208028)
NAD-dependent formate dehydrogenase 1A [Arabidopsis
thaliana] >gi|6625955|gb|AAF19436.1|AF208029_1
(AF208029) NAD-dependent formate dehydrogenase 1B
[Arabidopsis thaliana] >gi|6681408|dbj|BAA88683.1|
(AB023897) formate dehydrogenase [Arabidopsis thaliana]
>gi|7677266|gb|AAF67100.1|AF217195_1 (AF217195) formate
dehydrogenase [Arabidopsis thaliana]
>gi|9755746|emb|CAC01877.1| (AL391149) formate
dehydrogenase (FDH) [Arabidopsis thaliana]
Length = 384
Score = 154 bits (385), Expect = 1e-36
Identities = 89/282 (31%), Positives = 161/282 (56%), Gaps = 9/282 (3%)
Query: 35 ELKEIIPELDGIIIAPV--TRITKDILERAERLKVISCQSAGYDHVDVEEATKRGIYVTK 92
EL++ IP+L +I P +T + +++A+ LK++ G DH+D++ A G+ V +
Sbjct: 88 ELEKHIPDLHVLISTPFHPAYVTAERIKKAKNLKLLLTAGIGSDHIDLQAAAAAGLTVAE 147
Query: 93 VSGLLSEAVAEFALGLLISLMRKIHYADSFIREGKWESHTFVWREFKEVETLYGKEVGIV 152
V+G +VAE L ++ LMR + + +G+W +R + L GK +G V
Sbjct: 148 VTGSNVVSVAEDELMRILILMRNFVPGYNQVVKGEWNVAGIAYRAYD----LEGKTIGTV 203
Query: 153 GMGAIGKAIARRLKPFGCEIYYWSR-HRKEDIEREVNAKYL-DLDELLEEVDIVILALPL 210
G G IGK + +RLKPFGC + Y R ++E+E AK++ DL+E+L + D++++ +PL
Sbjct: 204 GAGRIGKLLLQRLKPFGCNLLYHDRLQMAPELEKETGAKFVEDLNEMLPKCDVIVINMPL 263
Query: 211 TKETYHIINEERVKKLE-GKYLVNIGRGALIDEKALVKAIKEGKLKGFATDVFEEEPVKE 269
T++T + N+E + KL+ G +VN RGA+++ +A+V A++ G + G++ DV++ +P +
Sbjct: 264 TEKTRGMFNKELIGKLKKGVLIVNNARGAIMERQAVVDAVESGHIGGYSGDVWDPQPAPK 323
Query: 270 HELFRFKWETVLTPHYAGLGKDVLEDMGFRAVENLLKVLRGE 311
+R+ +TPH +G D + L + +GE
Sbjct: 324 DHPWRYMPNQAMTPHTSGTTIDAQLRYAAGTKDMLERYFKGE 365
>gi|5729974 phosphoglycerate dehydrogenase; 3-phosphoglycerate dehydrogenase
[Homo sapiens] >gi|6094272|sp|O43175|SERA_HUMAN
D-3-PHOSPHOGLYCERATE DEHYDROGENASE (PGDH)
>gi|2674062|gb|AAB88664.1| (AF006043) 3-phosphoglycerate
dehydrogenase [Homo sapiens]
>gi|5771523|gb|AAD51415.1|AF171237_1 (AF171237)
3-phosphoglycerate dehydrogenase [Homo sapiens]
Length = 533
Score = 152 bits (381), Expect = 4e-36
Identities = 89/299 (29%), Positives = 157/299 (51%), Gaps = 8/299 (2%)
Query: 25 VVLKPYPSEEELKEIIPELDGIIIAPVTRITKDILERAERLKVISCQSAGYDHVDVEEAT 84
VV K S+EEL + + +G+I+ T++T D++ AE+L+V+ G D+VD+E AT
Sbjct: 30 VVEKQNLSKEELIAELQDCEGLIVRSATKVTADVINAAEKLQVVGRAGTGVDNVDLEAAT 89
Query: 85 KRGIYVTKVSGLLSEAVAEFALGLLISLMRKIHYADSFIREGKWESHTFVWREFKEVETL 144
++GI V S + AE G+++ L R+I A + +++GKWE F+ E L
Sbjct: 90 RKGILVMNTPNGNSLSAAELTCGMIMCLARQIPQATASMKDGKWERKKFMGTE------L 143
Query: 145 YGKEVGIVGMGAIGKAIARRLKPFGCEIYYWSRHRKEDIEREVNAKYLDLDELLEEVDIV 204
GK +GI+G+G IG+ +A R++ FG + + ++ + L L+E+ D +
Sbjct: 144 NGKTLGILGLGRIGREVATRMQSFGMKTIGYDPIISPEVSASFGVQQLPLEEIWPLCDFI 203
Query: 205 ILALPLTKETYHIINEERVKKL-EGKYLVNIGRGALIDEKALVKAIKEGKLKGFATDVFE 263
+ PL T ++N+ + +G +VN RG ++DE AL++A++ G+ G A DVF
Sbjct: 204 TVHTPLLPSTTGLLNDNTFAQCKKGVRVVNCARGGIVDEGALLRALQSGQCAGAALDVFT 263
Query: 264 EEPVKEHELFRFKWETVLTPHYAGLGKDVLEDMGFRAVENLLKVLRGEIPEDLVNKEVL 322
EEP ++ L + + PH K+ G + +++G+ +VN + L
Sbjct: 264 EEPPRDRALVDHE-NVISCPHLGASTKEAQSRCGEEIAVQFVDMVKGKSLTGVVNAQAL 321
>gi|11422415 phosphoglycerate dehydrogenase [Homo sapiens]
Length = 569
Score = 152 bits (381), Expect = 4e-36
Identities = 89/299 (29%), Positives = 157/299 (51%), Gaps = 8/299 (2%)
Query: 25 VVLKPYPSEEELKEIIPELDGIIIAPVTRITKDILERAERLKVISCQSAGYDHVDVEEAT 84
VV K S+EEL + + +G+I+ T++T D++ AE+L+V+ G D+VD+E AT
Sbjct: 66 VVEKQNLSKEELIAELQDCEGLIVRSATKVTADVINAAEKLQVVGRAGTGVDNVDLEAAT 125
Query: 85 KRGIYVTKVSGLLSEAVAEFALGLLISLMRKIHYADSFIREGKWESHTFVWREFKEVETL 144
++GI V S + AE G+++ L R+I A + +++GKWE F+ E L
Sbjct: 126 RKGILVMNTPNGNSLSAAELTCGMIMCLARQIPQATASMKDGKWERKKFMGTE------L 179
Query: 145 YGKEVGIVGMGAIGKAIARRLKPFGCEIYYWSRHRKEDIEREVNAKYLDLDELLEEVDIV 204
GK +GI+G+G IG+ +A R++ FG + + ++ + L L+E+ D +
Sbjct: 180 NGKTLGILGLGRIGREVATRMQSFGMKTIGYDPIISPEVSASFGVQQLPLEEIWPLCDFI 239
Query: 205 ILALPLTKETYHIINEERVKKL-EGKYLVNIGRGALIDEKALVKAIKEGKLKGFATDVFE 263
+ PL T ++N+ + +G +VN RG ++DE AL++A++ G+ G A DVF
Sbjct: 240 TVHTPLLPSTTGLLNDNTFAQCKKGVRVVNCARGGIVDEGALLRALQSGQCAGAALDVFT 299
Query: 264 EEPVKEHELFRFKWETVLTPHYAGLGKDVLEDMGFRAVENLLKVLRGEIPEDLVNKEVL 322
EEP ++ L + + PH K+ G + +++G+ +VN + L
Sbjct: 300 EEPPRDRALVDHE-NVISCPHLGASTKEAQSRCGEEIAVQFVDMVKGKSLTGVVNAQAL 357
>gb|AAC71709.1| (AF061070) PtxD [Pseudomonas stutzeri]
Length = 336
Score = 152 bits (380), Expect = 6e-36
Identities = 98/331 (29%), Positives = 172/331 (51%), Gaps = 16/331 (4%)
Query: 1 MKPRIGVLFKMKSKPLEELKKYTDVVLKPYPS---EEELKEIIPELDGIIIAPVTRITKD 57
M P++ + ++ + L+ L + +++ S EE+ + ++ R+ D
Sbjct: 1 MLPKLVITHRVHDEILQLLAPHCELMTNQTDSTLTREEILRRCRDAQAMMAFMPDRVDAD 60
Query: 58 ILERAERLKVISCQSAGYDHVDVEEATKRGIYVTKVSGLLSEAVAEFALGLLISLMRKIH 117
L+ L+V+ C G+D+ DV+ T RG+++T V LL+ AE A+GL + L R +
Sbjct: 61 FLQACPELRVVGCALKGFDNFDVDACTARGVWLTFVPDLLTVPTAELAIGLAVGLGRHLR 120
Query: 118 YADSFIREGKWESHTFVWREFKEVETLYGKEVGIVGMGAIGKAIARRLKPFGCEI-YYWS 176
AD+F+R G+++ W+ L VGI+GMGAIG A+A RL+ +G + Y+ +
Sbjct: 121 AADAFVRSGEFQG----WQPQFYGTGLDNATVGILGMGAIGLAMADRLQGWGATLQYHEA 176
Query: 177 RHRKEDIEREVNAKYLDLDELLEEVDIVILALPLTKETYHIINEERVKKLE-GKYLVNIG 235
+ E+ + + + EL D ++LALPL +T H++N E + + G LVN
Sbjct: 177 KALDTQTEQRLGLRQVACSELFASSDFILLALPLNADTQHLVNAELLALVRPGALLVNPC 236
Query: 236 RGALIDEKALVKAIKEGKLKGFATDVFEEEPVKEHELFRF-------KWETVLTPHYAGL 288
RG+++DE A++ A++ G+L G+A DVFE E + R T+ TPH
Sbjct: 237 RGSVVDEAAVLAALERGQLGGYAADVFEMEDWARADRPRLIDPALLAHPNTLFTPHIGSA 296
Query: 289 GKDVLEDMGFRAVENLLKVLRGEIPEDLVNK 319
+ V ++ A +N+++VL G P + N+
Sbjct: 297 VRAVRLEIERCAAQNIIQVLAGARPINAANR 327
>emb|CAA21970.1| (AL033497) YNL274C homologue [Candida albicans]
Length = 342
Score = 152 bits (379), Expect = 7e-36
Identities = 89/234 (38%), Positives = 132/234 (56%), Gaps = 3/234 (1%)
Query: 65 LKVISCQSAGYDHVDVEEATKRGIYVTKVSGLLSEAVAEFALGLLISLMRKIHYADSFIR 124
LK +S AGYD VDVE T+ G+ V+ V+ + A+ A+ L+++ MR +
Sbjct: 82 LKSVSHCGAGYDQVDVEPFTRLGVQVSNVTEPVERPTADVAVFLVLACMRNFLQGRQILM 141
Query: 125 EGKWESHTFVWREFKEV-ETLYGKEVGIVGMGAIGKAIARRLKPFGCEIYYWSRHRKEDI 183
G+W S+ + T GK VGI+GMG IG+AI RLKPFG + + ++
Sbjct: 142 NGEWPSNGDKEAAGAPLGHTPQGKVVGILGMGGIGRAIRDRLKPFGFDRIVYYNRKQLSS 201
Query: 184 EREVNAKYLDLDELLEEVDIVILALPLTKETYHIINEERVKKL-EGKYLVNIGRGALIDE 242
E E A+Y+ +DEL ++ D++I+ +PL +T H+I++E ++K+ +G LVNI RGA+IDE
Sbjct: 202 ELEKGAEYVTMDELFKQSDVIIIGVPLNAKTRHLIDKEAIQKMKDGVVLVNIARGAIIDE 261
Query: 243 KALVKAIKEGKLKGFATDVFEEEPVKEHELFRFKWETVLTPHYAGLGKDVLEDM 296
K L + IK GK+ F DVFE EP EL V PH + L +M
Sbjct: 262 KHLPELIKSGKIGAFGADVFEHEPEVSPELVNLP-NVVALPHMGTHSVEALTNM 314
>sp|O08651|SERA_RAT D-3-PHOSPHOGLYCERATE DEHYDROGENASE (PGDH)
>gi|1944614|emb|CAA66374.1| (X97772)
D-3-phosphoglycerate dehydrogenase [Rattus norvegicus]
>gi|7688285|emb|CAB89828.1| (AJ271975)
3-phosphoglycerate dehydrogenase [Rattus norvegicus]
Length = 533
Score = 151 bits (378), Expect = 1e-35
Identities = 88/299 (29%), Positives = 157/299 (52%), Gaps = 8/299 (2%)
Query: 25 VVLKPYPSEEELKEIIPELDGIIIAPVTRITKDILERAERLKVISCQSAGYDHVDVEEAT 84
VV K S+EEL + + +G+I+ T++T D++ AE+L+V+ G D+VD+E AT
Sbjct: 30 VVEKQNLSKEELIAELQDCEGLIVRSATKVTADVINAAEKLQVVGRAGTGVDNVDLEAAT 89
Query: 85 KRGIYVTKVSGLLSEAVAEFALGLLISLMRKIHYADSFIREGKWESHTFVWREFKEVETL 144
++G+ V S + AE G+L+ L R+I A + +++GKW+ F+ E L
Sbjct: 90 RKGVLVMNTPNGNSLSAAELTCGMLMCLARQIPQATASMKDGKWDRKKFMGTE------L 143
Query: 145 YGKEVGIVGMGAIGKAIARRLKPFGCEIYYWSRHRKEDIEREVNAKYLDLDELLEEVDIV 204
GK +GI+G+G IG+ +A R++ FG + + ++ + L L+E+ D +
Sbjct: 144 NGKTLGILGLGRIGREVAARMQAFGMKTVGYDPIISPEVAASFGVQQLPLEEIWPLCDFI 203
Query: 205 ILALPLTKETYHIINEERVKKL-EGKYLVNIGRGALIDEKALVKAIKEGKLKGFATDVFE 263
+ PL T ++N+ + +G +VN RG ++DE AL++A++ G+ G A DVF
Sbjct: 204 TVHTPLLPSTTGLLNDSTFAQCKKGVRVVNCARGGIVDEGALLRALQSGQCAGAALDVFT 263
Query: 264 EEPVKEHELFRFKWETVLTPHYAGLGKDVLEDMGFRAVENLLKVLRGEIPEDLVNKEVL 322
EEP ++ L + + PH K+ G + +++G+ +VN + L
Sbjct: 264 EEPPRDRALVDHE-NVISCPHLGASTKEAQSRCGEEIAVQFVDMVKGKSLTGVVNAQAL 321
>dbj|BAA99698.1| (AB025624) phosphoglycerate dehydrogenase [Arabidopsis thaliana]
Length = 588
Score = 151 bits (378), Expect = 1e-35
Identities = 101/333 (30%), Positives = 166/333 (49%), Gaps = 10/333 (3%)
Query: 2 KPRIGVLFKMKSKPLEELKKYTDVVLKPYPSEEELKEIIPELDGIIIAPVTRITKDILER 61
KP I V K+ ++ LKKY +V S EEL I D +I+ T++ +D+ E
Sbjct: 46 KPTILVTEKLGQAGIDLLKKYANVDCSYDLSLEELCTKISLCDALIVRSGTKVGRDVFES 105
Query: 62 AE-RLKVISCQSAGYDHVDVEEATKRGIYVTKVSGLLSEAVAEFALGLLISLMRKIHYAD 120
+ RLKV+ G D+VD+ AT+ G V + A AE + LL ++ R I AD
Sbjct: 106 SRGRLKVVGRAGVGIDNVDLAAATEYGCLVVNAPTANTVAAAEHGIALLTAMARNIAQAD 165
Query: 121 SFIREGKWESHTFVWREFKEVETLYGKEVGIVGMGAIGKAIARRLKPFGCEIYYWSRHRK 180
+ I+ GKW + +V +L GK + ++G G +G +ARR + G + +
Sbjct: 166 ASIKAGKWTRNKYVG------VSLVGKTLAVLGFGKVGSEVARRARGLGMHVITHDPYAP 219
Query: 181 EDIEREVNAKYLDLDELLEEVDIVILALPLTKETYHIINEERVKKLE-GKYLVNIGRGAL 239
D R + + + + + D + L LPLT T ++N+ ++ G +VN+ RG +
Sbjct: 220 ADRARAIGVELVSFEVAISTADFISLHLPLTAATSKMMNDVTFAMMKKGVRIVNVARGGV 279
Query: 240 IDEKALVKAIKEGKLKGFATDVFE-EEPVKEHELFRFKWETVLTPHYAGLGKDVLEDMGF 298
IDE+AL++A+ G + A DVF E PVK+++L + T TPH + E +
Sbjct: 280 IDEEALLRALDSGIVAQAALDVFTVEPPVKDNKLVLHESVTA-TPHLGASTMEAQEGVSI 338
Query: 299 RAVENLLKVLRGEIPEDLVNKEVLKVRPIDEVK 331
E ++ LRGE+ VN ++ + + E+K
Sbjct: 339 EVAEAVIGALRGELAATAVNAPMVPLEVLRELK 371
>gb|AAF51963.1| (AE003602) CG1236 gene product [Drosophila melanogaster]
Length = 325
Score = 151 bits (377), Expect = 1e-35
Identities = 93/286 (32%), Positives = 150/286 (51%), Gaps = 7/286 (2%)
Query: 29 PYPSEEELKEIIPELDGIIIAPVTRITKDILERA-ERLKVISCQSAGYDHVDVEEATKRG 87
P P EL ++ D + A ++ K++L+ A +LK ++ S GYDH+DVEE KRG
Sbjct: 36 PVP-RSELIRVVAGKDALYCALTDKVDKEVLDAAGPQLKCVATISVGYDHIDVEECRKRG 94
Query: 88 IYVTKVSGLLSEAVAEFALGLLISLMRKIHYADSFIREGKWESHTFVWREFKEVETLYGK 147
I V +L++A AE L LL++ R++ A+ + G W+S +W + L G
Sbjct: 95 IRVGFTPDVLTDATAELTLALLLATNRRLFEANKQVYNGGWKSWAPMW---MCGQGLKGS 151
Query: 148 EVGIVGMGAIGKAIARRLKPF-GCEIYYWSRHRKEDIEREVNAKYLDLDELLEEVDIVIL 206
VG++G G IG+ IA R+ PF EI Y +R + VNA+++D DE+L E D++++
Sbjct: 152 RVGLLGFGRIGQEIAARIVPFKPTEITYTTRSLRPKEAAAVNARHVDFDEMLRESDLIVV 211
Query: 207 ALPLTKETYHIINEERVKKLEGK-YLVNIGRGALIDEKALVKAIKEGKLKGFATDVFEEE 265
LT ET I N +K++ L+N RG ++D+KAL +A+K ++ DV E
Sbjct: 212 CCALTPETKEIFNATAFQKMKPNCILINTARGGVVDQKALYEALKTKRILAAGLDVTTPE 271
Query: 266 PVKEHELFRFKWETVLTPHYAGLGKDVLEDMGFRAVENLLKVLRGE 311
P+ + V+ PH + ++M N+L L G+
Sbjct: 272 PLPIDDPLLKLDNVVILPHIGSADIETRKEMSRITARNILAALAGD 317
>gb|AAF00955.1|AF183408_3 (AF183408) McyI [Microcystis aeruginosa]
Length = 337
Score = 150 bits (375), Expect = 2e-35
Identities = 101/324 (31%), Positives = 169/324 (51%), Gaps = 11/324 (3%)
Query: 2 KPRIGVLFKMKSKPLEEL-KKYTDVVLKPYPSEEELKEIIPELDGIIIAPVTRITKDILE 60
KPR+ ++ KM + ++L ++ T++ + P+ EE+ E I E+ G+ + + +
Sbjct: 15 KPRVLLIGKMYDEAGQKLLEESTNIEILSNPTPEEINEAIQEVSGVFVRYPNNLEASSIR 74
Query: 61 RAERLKVISCQSAGYDHVDVEEATKRGIYVTKVSGLLSEAVAEFALGLLISLMRKIHYAD 120
A+ LKVIS G D +D+ AT++G+ V G+ + AVAE L ++++L +K+ + D
Sbjct: 75 LAKHLKVISTSGFGTDSIDIMAATEQGVIVVNNPGMSTTAVAEHTLSMILALAKKLPFLD 134
Query: 121 SFIREGKWESHTFVWREFKEVETLYGKEVGIVGMGAIGKAIARRLK-PFGCEIYYWSRHR 179
+++G ++ R + L K +GIVG+G IG +A + G + + +
Sbjct: 135 HCVKKG-----NYLIRNQMQPIQLENKTLGIVGLGRIGTLVAHKCNLALGMRVLAYDPYV 189
Query: 180 KEDIEREVNAKYL-DLDELLEEVDIVILALPLTKETYHIINEERVKKLE-GKYLVNIGRG 237
V A L DLD LL E D V L LT ET + N KK++ +L+N RG
Sbjct: 190 PASKAETVGATLLKDLDVLLAESDFVSLHTELTSETREMFNISVFKKMKPTAFLINTSRG 249
Query: 238 ALIDEKALVKAIKEGKLKGFATDVFE-EEPVKEHELFRFKWETVLTPHYAGLGKDVLEDM 296
++ EK L A+ + + G A DVFE E P ++ L+ F+ +L+PH AG+ +
Sbjct: 250 KVVCEKDLGIALNQKLISGCALDVFEPEPPALDNPLYNFE-NVILSPHLAGVTPEASLAA 308
Query: 297 GFRAVENLLKVLRGEIPEDLVNKE 320
A +L+VLRGE P ++N E
Sbjct: 309 AVSAANQILQVLRGEKPPYMINPE 332
>emb|CAC11910.1| (AL445065) 2-hydroxyacid dehydrogenase related protein
[Thermoplasma acidophilum]
Length = 309
Score = 150 bits (375), Expect = 2e-35
Identities = 92/302 (30%), Positives = 159/302 (52%), Gaps = 12/302 (3%)
Query: 15 PLEELKKYTDVVLKPYPSEEELKEIIPELDGIIIAPVTRITKDILERAERLKVISCQSAG 74
PL++++ + + + + + +I+ T + D+L++ RL+ + S G
Sbjct: 12 PLDQIRSAVSTITQDVEVRTDTDFDRSDAEILIVTTFTPVNGDLLKKMPRLRFVQVASIG 71
Query: 75 YDHVDVEEATKRGIYVTKVSGLLSEAVAEFALGLLISLMRKIHYADSFIREGKWESHTFV 134
YD+VD+ K GI V+ + +++VAE AL +++SL++ + D+ IR G+W T
Sbjct: 72 YDNVDMNAMKKNGIMVSNIPTASADSVAEHALSMVLSLIKDQRFLDAEIRSGRWPRIT-- 129
Query: 135 WREFKEVETLYGKEVGIVGMGAIGKAIARRLKPFGCEIYYWSRHR-KEDIEREVNAKYLD 193
L GK GIVGMG+IG+A+A RL PF I Y R E E E A ++
Sbjct: 130 -----RSSDLMGKTFGIVGMGSIGRALAARLLPFKVAIIYNDTKRMSEAEEEEYGATFVS 184
Query: 194 LDELLEEVDIVILALPLTKETYHIINEERVKKL-EGKYLVNIGRGALIDEKALVKAIKEG 252
LD LL + D++ + +PL + T H+ N R + +G +N RG ++ EK L++AI++
Sbjct: 185 LDRLLSDSDVISVHVPLNETTRHMFNSSRFGLMKDGAIFINTSRGEVVVEKDLIEAIQKK 244
Query: 253 KLKGFATDVFEEEPVKEHE-LFRFKWETVLTPHYAGLGKDVLEDMGFRAVENLLKVLRGE 311
++ DVFE EP + LFR + T+ +PH AG+ + + N+++ ++G
Sbjct: 245 GIRA-GLDVFEHEPPDPNSPLFRLE-NTLFSPHIAGVTAESQMRFFRETIANVMRYMQGY 302
Query: 312 IP 313
P
Sbjct: 303 DP 304
>dbj|BAB12215.1| (AB032549) d-3-phosphoglycerate dehydrogenase [Microcystis
aeruginosa]
Length = 337
Score = 149 bits (372), Expect = 5e-35
Identities = 99/325 (30%), Positives = 173/325 (52%), Gaps = 11/325 (3%)
Query: 2 KPRIGVLFKMKSKPLEEL-KKYTDVVLKPYPSEEELKEIIPELDGIIIAPVTRITKDILE 60
KPR+ ++ KM + ++L ++ T++ + P+ EE+ E I E+ G+ + ++ +
Sbjct: 15 KPRVLLIGKMYDEAGQKLLEESTNIEILSNPTLEEINEAIQEVSGVFVRYPNKLEASSIR 74
Query: 61 RAERLKVISCQSAGYDHVDVEEATKRGIYVTKVSGLLSEAVAEFALGLLISLMRKIHYAD 120
A++LKVIS G D +D+ AT++G+ V G+ + +VAE L ++++L +K+ + D
Sbjct: 75 LAKQLKVISTSGFGTDSIDIMAATEQGVIVVNNPGMSTTSVAEHTLSMILALAKKLPFLD 134
Query: 121 SFIREGKWESHTFVWREFKEVETLYGKEVGIVGMGAIGKAIARRLK-PFGCEIYYWSRHR 179
+++G ++ R + L K +GIVG+G IG +A + G + + +
Sbjct: 135 HCVKKG-----NYLIRNQMQPIQLENKTLGIVGLGRIGTLVAHKCNLALGMRVLAYDPYV 189
Query: 180 KEDIEREVNAKYL-DLDELLEEVDIVILALPLTKETYHIINEERVKKLE-GKYLVNIGRG 237
V A ++ DLD LL E D V L LT ET + N KK++ +L+N RG
Sbjct: 190 PASKAETVGATWVKDLDVLLAESDFVSLHTELTSETREMFNISVFKKMKPTAFLINTSRG 249
Query: 238 ALIDEKALVKAIKEGKLKGFATDVFE-EEPVKEHELFRFKWETVLTPHYAGLGKDVLEDM 296
++ EK L A+ + + G A DVFE E P ++ L+ F+ +L+PH AG+ +
Sbjct: 250 KVVCEKDLGIALNQKLIAGCALDVFEPEPPALDNPLYNFE-NVILSPHLAGVTPEASLAA 308
Query: 297 GFRAVENLLKVLRGEIPEDLVNKEV 321
A +L+VL+GE P ++N EV
Sbjct: 309 AVSAANQILQVLQGEKPPYMINPEV 333
>pir||T05416 probable phosphoglycerate dehydrogenase (EC 1.1.1.95) - Arabidopsis
thaliana >gi|2911042|emb|CAA17552.1| (AL021961)
Phosphoglycerate dehydrogenase-like protein [Arabidopsis
thaliana] >gi|7270370|emb|CAB80137.1| (AL161585)
Phosphoglycerate dehydrogenase-like protein [Arabidopsis
thaliana]
Length = 603
Score = 148 bits (369), Expect = 1e-34
Identities = 97/333 (29%), Positives = 164/333 (49%), Gaps = 10/333 (3%)
Query: 2 KPRIGVLFKMKSKPLEELKKYTDVVLKPYPSEEELKEIIPELDGIIIAPVTRITKDILER 61
KP I V K+ ++ L+ +V + EEL I D +I+ T++ +++ E
Sbjct: 61 KPTILVAEKLGDAGIKLLEDVANVDCSYNMTPEELNIKISLCDALIVRSGTKVGREVFES 120
Query: 62 AE-RLKVISCQSAGYDHVDVEEATKRGIYVTKVSGLLSEAVAEFALGLLISLMRKIHYAD 120
+ RLKV+ G D+VD+ AT+ G V + A AE + L+ ++ R + AD
Sbjct: 121 SHGRLKVVGRAGVGIDNVDLSAATEFGCLVVNAPTANTIAAAEHGIALMAAMARNVAQAD 180
Query: 121 SFIREGKWESHTFVWREFKEVETLYGKEVGIVGMGAIGKAIARRLKPFGCEIYYWSRHRK 180
+ ++ G+W+ + +V +L GK + ++G G +G +ARR K G + +
Sbjct: 181 ASVKAGEWKRNKYVG------VSLVGKTLAVLGFGKVGTEVARRAKGLGMRVIAHDPYAP 234
Query: 181 EDIEREVNAKYLDLDELLEEVDIVILALPLTKETYHIINEERVKKLE-GKYLVNIGRGAL 239
D + + DE L D + L +PLT T I+N+E K++ G +VN+ RG +
Sbjct: 235 ADRAHAIGVDLVSFDEALATADFISLHMPLTPTTSKILNDETFAKMKKGVRIVNVARGGV 294
Query: 240 IDEKALVKAIKEGKLKGFATDVF-EEEPVKEHELFRFKWETVLTPHYAGLGKDVLEDMGF 298
IDE ALV+A+ G + A DVF +E P K+ +L + + TV TPH + E +
Sbjct: 295 IDEDALVRALDAGIVAQAALDVFTKEPPAKDSKLVQHERVTV-TPHLGASTMEAQEGVAI 353
Query: 299 RAVENLLKVLRGEIPEDLVNKEVLKVRPIDEVK 331
E ++ L GE+ VN ++ + E+K
Sbjct: 354 EIAEAVVGALNGELAATAVNAPMVSAEVLTELK 386
>pir||G70363 D-lactate dehydrogenase - Aquifex aeolicus
>gi|2983307|gb|AAC06898.1| (AE000704) D-lactate
dehydrogenase [Aquifex aeolicus]
Length = 334
Score = 148 bits (369), Expect = 1e-34
Identities = 101/330 (30%), Positives = 174/330 (52%), Gaps = 32/330 (9%)
Query: 3 PRIGVLFKMKSKPLEELKKYTDVVLKPYPSEEELKEIIPELDGIIIAPVTRITKDILERA 62
P+ V F ++ LK YT V K E ELK+ EL + + ++T+++L +
Sbjct: 9 PQEDVPFYQEALKDLSLKIYTTDVSKV--PENELKKA--ELISVFV--YDKLTEELLSKM 62
Query: 63 ERLKVISCQSAGYDHVDVEEATKRGIYVTKVSGLLSEAVAEFALGLLISLMRKIHYADSF 122
RLK+I +S G+DH+D++ K+GI VT + E+VAE ++++L++++ +
Sbjct: 63 PRLKLIHTRSVGFDHIDLDYCKKKGILVTHIPAYSPESVAEHTFAMILTLVKRLKRIEDR 122
Query: 123 IREGKWESHTFVWREFKEVETLYGKEVGIVGMGAIGKAIARRLKPFGCEIYYWSRHRKED 182
+++ + + + +E+ L +G++G G IG +A FG ++ + ++ED
Sbjct: 123 VKKLNFSQDSEILA--RELNRL---TLGVIGTGRIGSRVAMYGLAFGMKVLCYDVVKRED 177
Query: 183 IEREVNAKYLDLDELLEEVDIVILALPLTKETYHIINEERVKKL-EGKYLVNIGRGALID 241
+ +E Y LDELL+E D++ L +P TKET+H+INEER+ + +G YL+N RG ++D
Sbjct: 178 L-KEKGCVYTSLDELLKESDVISLHVPYTKETHHMINEERISLMKDGVYLINTARGKVVD 236
Query: 242 EKALVKAIKEGKLKGFATDVFEEEPV-------------KEHELFRF--KWETVLTPHYA 286
AL +A + GK G DVFE+E + K ++ K ++TPH A
Sbjct: 237 TDALYRAYQRGKFSGLGLDVFEDEEILILKKYTEGKATDKNLKILELACKDNVIITPHIA 296
Query: 287 GLGKDVLEDMGFRAVENLLKVLRGEIPEDL 316
LE R E +KV++ + DL
Sbjct: 297 YYTDKSLE----RIREETVKVVKAFVKGDL 322
>emb|CAB61802.1| (AL133236) putative dehydrogenase [Streptomyces coelicolor A3(2)]
Length = 344
Score = 147 bits (367), Expect = 2e-34
Identities = 98/281 (34%), Positives = 146/281 (51%), Gaps = 14/281 (4%)
Query: 47 IIAPVTRITKDILERAERLKVISCQSAGYDHVDVEEATKRGIYVTKVSGLLSEAVAEFAL 106
I+ IT+ +++R RLKVI G D VDVE AT+RGI V V +EAV++ A+
Sbjct: 62 IVVQYAAITEQVMDRLPRLKVIGRYGVGVDSVDVEAATRRGILVCNVPDYGTEAVSDHAI 121
Query: 107 GLLISLMRKIHYADSFIREGKWESHTFVWREFKEVETLY--GKEV-GIVGMGAIGKAIAR 163
GL +S+ R I D +R G + + V LY G+ V G+VGMG IG A AR
Sbjct: 122 GLALSVARGIPRLDRGVRAGSF--------DLPAVRPLYQVGQRVFGVVGMGLIGAATAR 173
Query: 164 RLKPFGCEIYYWSRHRKEDIEREVNAKYLDLDELLEEVDIVILALPLTKETYHIINEERV 223
+ G ++ + D + + + L ELLE +V + PLT++T ++ +
Sbjct: 174 KAAGLGYDVIAYDSAADPDAQTFRGFRSVGLHELLERAQVVSVHTPLTEQTRGLLGADAF 233
Query: 224 KKLE-GKYLVNIGRGALIDEKALVKAIKEGKLKGFATDVFEEEPV-KEHELFRFKWETVL 281
++ +VN RG +ID ALV A+K G + G DV E EP+ ++H L F VL
Sbjct: 234 ARMRPDAIVVNTSRGGVIDTGALVDALKRGAVAGAGIDVHEIEPLPRDHPLTSFD-NVVL 292
Query: 282 TPHYAGLGKDVLEDMGFRAVENLLKVLRGEIPEDLVNKEVL 322
TPH A ++ ++ R VEN++ G P ++VN E L
Sbjct: 293 TPHLAWYSEESYAELKRRTVENVVDACAGRTPRNVVNPEAL 333
>pir||D83529 D-lactate dehydrogenase (fermentative) PA0927 [imported] -
Pseudomonas aeruginosa (strain PAO1)
>gi|9946831|gb|AAG04316.1|AE004527_3 (AE004527)
D-lactate dehydrogenase (fermentative) [Pseudomonas
aeruginosa]
Length = 329
Score = 146 bits (366), Expect = 2e-34
Identities = 93/267 (34%), Positives = 150/267 (55%), Gaps = 23/267 (8%)
Query: 54 ITKDILER--AERLKVISCQSAGYDHVDVEEATKRGIYVTKVSGLLSEAVAEFALGLLIS 111
+++ +LER A ++++ +SAGY+HVD+ A G+ V V AVAE A+GL+++
Sbjct: 56 LSRPVLERLAAGGTRLVALRSAGYNHVDLAAAEALGLPVVHVPAYSPHAVAEHAVGLILT 115
Query: 112 LMRKIHYADSFIREGKWESHTFVWREFKEVETLYGKEVGIVGMGAIGKAIARRLKPFGCE 171
L R++H A + REG + H + L+GK VG++G G IG+ AR + FGCE
Sbjct: 116 LNRRLHRAYNRTREGDFSLHGLTGFD------LHGKRVGVIGTGQIGETFARIMAGFGCE 169
Query: 172 IYYWSRHRKEDIEREVNAKYLDLDELLEEVDIVILALPLTKETYHIINEERVKKLE-GKY 230
+ + + I+ + +YL LD LL E DIV L PLT +T H+I+ +R+ ++ G
Sbjct: 170 LLAYDPYPNPRIQ-ALGGRYLALDALLAESDIVSLHCPLTADTRHLIDAQRLATMKPGAM 228
Query: 231 LVNIGRGALIDEKALVKAIKEGKLKGFATDVFEEE-----------PVKEHELFRFKW-- 277
L+N GRGAL++ AL++A+K G+L DV+EEE P+++ L R
Sbjct: 229 LINTGRGALVNAAALIEALKSGQLGYLGLDVYEEEADIFFEDRSDQPLQDDVLARLLSFP 288
Query: 278 ETVLTPHYAGLGKDVLEDMGFRAVENL 304
V+T H A L ++ L + ++N+
Sbjct: 289 NVVVTAHQAFLTREALAAIADTTLDNI 315
>sp|Q07511|FDH_SOLTU MITOCHONDRIAL FORMATE DEHYDROGENASE PRECURSOR (NAD-DEPENDENT
FORMATE DEHYDROGENASE) (FDH) >gi|542089|pir||JQ2272
formate dehydrogenase (EC 1.2.1.2) precursor,
mitochondrial - potato >gi|297798|emb|CAA79702.1|
(Z21493) mitochondrial formate dehydrogenase precursor
[Solanum tuberosum]
Length = 379
Score = 146 bits (365), Expect = 3e-34
Identities = 85/258 (32%), Positives = 149/258 (56%), Gaps = 9/258 (3%)
Query: 35 ELKEIIPELDGIIIAPV--TRITKDILERAERLKVISCQSAGYDHVDVEEATKRGIYVTK 92
EL++ IP+L +I P +T + +++A+ L+++ G DHVD++ A G+ V +
Sbjct: 83 ELEKHIPDLHVLISTPFHPAYVTAERIKKAKNLQLLLTAGIGSDHVDLKAAAAAGLTVAE 142
Query: 93 VSGLLSEAVAEFALGLLISLMRKIHYADSFIREGKWESHTFVWREFKEVETLYGKEVGIV 152
V+G + +VAE L ++ L+R + G+W R + L GK VG V
Sbjct: 143 VTGSNTVSVAEDELMRILILVRNFLPGHHQVINGEWNVAAIAHRAYD----LEGKTVGTV 198
Query: 153 GMGAIGKAIARRLKPFGCEIYYWSRHRKE-DIEREVNAKYL-DLDELLEEVDIVILALPL 210
G G IG+ + +RLKPF C + Y R + + ++E ++ AK+ DLD++L + DIV++ PL
Sbjct: 199 GAGRIGRLLLQRLKPFNCNLLYHDRLKMDSELENQIGAKFEEDLDKMLSKCDIVVINTPL 258
Query: 211 TKETYHIINEERVKKLE-GKYLVNIGRGALIDEKALVKAIKEGKLKGFATDVFEEEPVKE 269
T++T + ++ER+ KL+ G +VN RGA++D +A+V A G + G++ DV+ +P +
Sbjct: 259 TEKTKGMFDKERIAKLKKGVLIVNNARGAIMDTQAVVDACNSGHIAGYSGDVWYPQPAPK 318
Query: 270 HELFRFKWETVLTPHYAG 287
+R+ +TPH +G
Sbjct: 319 DHPWRYMPNQAMTPHISG 336
>gb|AAF53930.1| (AE003668) CG9332 gene product [Drosophila melanogaster]
Length = 598
Score = 145 bits (362), Expect = 7e-34
Identities = 98/300 (32%), Positives = 154/300 (50%), Gaps = 7/300 (2%)
Query: 16 LEELKKYTDVVLKPYPSEEELKEIIPELDGIIIAPVTRITKDILERA-ERLKVISCQSAG 74
L+E + V+ +P + E+ E I +I + +IL+ A +LK +S S+G
Sbjct: 295 LKEQCEILQVINEPPKNRPEILEKIRGAHAVIWGGRDILNAEILDAAGPQLKAVSTMSSG 354
Query: 75 YDHVDVEEATKRGIYVTKVSGLLSEAVAEFALGLLISLMRKIHYADSFIREGKWESHTFV 134
++VDV E KRGI + +L+ AVA+ +GLLI+ R+ I KW+
Sbjct: 355 INNVDVPELKKRGIPLGSTPAMLTVAVADLTVGLLIAAARRFQEGRRKIDSDKWDKDHLN 414
Query: 135 WREFKEVETLYGKEVGIVGMGAIGKAIARRLKPFGCE-IYYWSRHR-KEDIEREVNAKYL 192
W +++ VG G G IG+A+A+RL F + + Y +R+R +DIE NAK +
Sbjct: 415 WMLGQDIR---DSTVGFYGFGGIGQAVAKRLMGFDIKRMLYTTRNRVSQDIEERFNAKKV 471
Query: 193 DLDELLEEVDIVILALPLTKETYHIINEERVKKL-EGKYLVNIGRGALIDEKALVKAIKE 251
D + LL E D +I+A PLTKET + N K+ E LVN+GRG ++++ L +A+K
Sbjct: 472 DFETLLAESDFLIIASPLTKETLGLFNATVFNKMKETAVLVNVGRGKIVNQDDLYEALKS 531
Query: 252 GKLKGFATDVFEEEPVKEHELFRFKWETVLTPHYAGLGKDVLEDMGFRAVENLLKVLRGE 311
++ DV + EP+ ++ V+TPH + D A N+LK L GE
Sbjct: 532 NRIFAAGLDVMDPEPLPSNDKLLTLDNVVVTPHVGYATRRTRVDAANLASRNVLKGLAGE 591
Score = 103 bits (254), Expect = 3e-21
Identities = 68/213 (31%), Positives = 112/213 (51%), Gaps = 8/213 (3%)
Query: 29 PYPSEEELKEIIPELDGIIIAPVTRITKDILERAERLKVISCQSAGYDHVDVEEATKRGI 88
P P+ E L+ E II V +IL++ L+ +S S+G D VD+ E KRGI
Sbjct: 41 PAPALELLRSRGAET--IICQSVPPSRDEILQKVPGLRCVSTMSSGIDFVDIPEFQKRGI 98
Query: 89 YVTKVSGLLSEAVAEFALGLLISLMRKIHYADSFIREGKWESHTFVWREFKEVETLYGKE 148
+ G++ AVA+ A+GL+I+ R H + I +W+ W +E+
Sbjct: 99 PLGHTPGVVKNAVADLAIGLMIAAGRHFHAGRTEIERSQWKIEQINWMMGQEIR---DSV 155
Query: 149 VGIVGMGAIGKAIARRLKPFG-CEIYYWSRHRKEDIEREVNAKYLDLDELLEEVDIVILA 207
+G G G I +AIA+RL+ + +I Y +R RKE+ + + A+++ ++LL+E D +++A
Sbjct: 156 IGFFGFGGISQAIAKRLQCWDVAKIIYHTRTRKEN-DGDFKAEHVSFEQLLQESDFLVVA 214
Query: 208 LPLTKETYHIINEERVKKLE-GKYLVNIGRGAL 239
PLT ET N + ++ VN+ RG L
Sbjct: 215 APLTNETREKFNGKAFNLMKRSSVFVNVARGGL 247
>sp|O88712|CTB1_MOUSE C-TERMINAL BINDING PROTEIN 1 >gi|3452507|emb|CAA09219.1| (AJ010483)
CtBP1 protein [Mus musculus]
Length = 440
Score = 144 bits (359), Expect = 2e-33
Identities = 92/305 (30%), Positives = 157/305 (51%), Gaps = 5/305 (1%)
Query: 19 LKKYTDVVLKPYPSEEELKE-IIPELDGIIIAPVTRITKDILERAERLKVISCQSAGYDH 77
LK V S +E+ E ++ E G ++ +T++ LE+ + L++I +G+D+
Sbjct: 45 LKDVATVAFCDAQSTQEIHEKVLNEAVGALMYHTITLTREDLEKFKALRIIVRIGSGFDN 104
Query: 78 VDVEEATKRGIYVTKVSGLLSEAVAEFALGLLISLMRKIHYADSFIREGKWESHTFVWRE 137
+D++ A GI V V E A+ L +++L R+ + +REG RE
Sbjct: 105 IDIKSAGDLGIAVCNVPAASVEETADSTLCHILNLYRRTTWLHQALREGTRVQSVEQIRE 164
Query: 138 FKE-VETLYGKEVGIVGMGAIGKAIARRLKPFGCEIYYWSRHRKEDIEREVNAKYLD-LD 195
+ G+ +GI+G+G +G+A+A R K FG + ++ + + IER + + + L
Sbjct: 165 VASGAARIRGETLGIIGLGRVGQAVALRAKAFGFNVLFYDPYLSDGIERALGLQRVSTLQ 224
Query: 196 ELLEEVDIVILALPLTKETYHIINEERVKKL-EGKYLVNIGRGALIDEKALVKAIKEGKL 254
+LL D V L L + +H+IN+ VK++ +G +LVN RG L+DEKAL +A+KEG++
Sbjct: 225 DLLFHSDCVTLHCGLNEHNHHLINDFTVKQMRQGAFLVNTARGGLVDEKALAQALKEGRI 284
Query: 255 KGFATDVFEEEPVK-EHELFRFKWETVLTPHYAGLGKDVLEDMGFRAVENLLKVLRGEIP 313
+G A DV E EP + + TPH A + +M A + + + G IP
Sbjct: 285 RGAALDVHESEPFSFSQGPLKDAPNLICTPHAAWYSEQASIEMREEAAREIRRAITGRIP 344
Query: 314 EDLVN 318
+ L N
Sbjct: 345 DSLKN 349
>gb|AAD14596.1| (AF091554) C-terminal binding protein [Xenopus laevis]
Length = 440
Score = 144 bits (359), Expect = 2e-33
Identities = 90/305 (29%), Positives = 158/305 (51%), Gaps = 5/305 (1%)
Query: 19 LKKYTDVVLKPYPSEEELKE-IIPELDGIIIAPVTRITKDILERAERLKVISCQSAGYDH 77
LK V S +E+ E ++ E G ++ +T++ LE+ + L++I +G+D+
Sbjct: 45 LKDVATVAFCDAQSTQEIHEKVLNEAVGALMYHTITLTREDLEKFKALRIIVRIGSGFDN 104
Query: 78 VDVEEATKRGIYVTKVSGLLSEAVAEFALGLLISLMRKIHYADSFIREGKWESHTFVWRE 137
+D++ A GI V V E A+ + +++L R+ + +REG RE
Sbjct: 105 IDIKSAGDLGIAVCNVPAASVEETADSTMCHILNLYRRTTWLHQALREGTRVQSVEQIRE 164
Query: 138 FKE-VETLYGKEVGIVGMGAIGKAIARRLKPFGCEIYYWSRHRKEDIEREVNAKYLD-LD 195
+ G+ +GI+G+G +G+A+A R K FG ++++ + + IER + + + L
Sbjct: 165 VASGAARIRGETLGIIGLGRVGQAVALRAKTFGFNVFFYDPYLSDGIERALGLQRVSTLQ 224
Query: 196 ELLEEVDIVILALPLTKETYHIINEERVKKL-EGKYLVNIGRGALIDEKALVKAIKEGKL 254
+LL D V L L + +H+IN+ +K++ +G +LVN RG L+DEKAL +A+KEG++
Sbjct: 225 DLLFHSDCVTLHCGLNEHNHHLINDFTIKQMRQGAFLVNTARGGLVDEKALAQALKEGRI 284
Query: 255 KGFATDVFEEEPVK-EHELFRFKWETVLTPHYAGLGKDVLEDMGFRAVENLLKVLRGEIP 313
+G A DV E EP + + TPH A + +M A + + + G IP
Sbjct: 285 RGAALDVHESEPFSFTQGPLKDAPNLICTPHAAWYSEQASIEMREEAAREIRRAITGRIP 344
Query: 314 EDLVN 318
+ L N
Sbjct: 345 DSLKN 349
>gi|7304989 C-terminal binding protein 1 [Mus musculus]
>gi|6015474|dbj|BAA85180.1| (AB033122) C-terminal
binding protein 1 [Mus musculus]
Length = 441
Score = 144 bits (359), Expect = 2e-33
Identities = 92/305 (30%), Positives = 157/305 (51%), Gaps = 5/305 (1%)
Query: 19 LKKYTDVVLKPYPSEEELKE-IIPELDGIIIAPVTRITKDILERAERLKVISCQSAGYDH 77
LK V S +E+ E ++ E G ++ +T++ LE+ + L++I +G+D+
Sbjct: 45 LKDVATVAFCDAQSTQEIHEKVLNEAVGALMYHTITLTREDLEKFKALRIIVRIGSGFDN 104
Query: 78 VDVEEATKRGIYVTKVSGLLSEAVAEFALGLLISLMRKIHYADSFIREGKWESHTFVWRE 137
+D++ A GI V V E A+ L +++L R+ + +REG RE
Sbjct: 105 IDIKSAGDLGIAVCNVPAASVEETADSTLCHILNLYRRTTWLHQALREGTRVQSVEQIRE 164
Query: 138 FKE-VETLYGKEVGIVGMGAIGKAIARRLKPFGCEIYYWSRHRKEDIEREVNAKYLD-LD 195
+ G+ +GI+G+G +G+A+A R K FG + ++ + + IER + + + L
Sbjct: 165 VASGAARIRGETLGIIGLGRVGQAVALRAKAFGFNVLFYDPYLSDGIERALGLQRVSTLQ 224
Query: 196 ELLEEVDIVILALPLTKETYHIINEERVKKL-EGKYLVNIGRGALIDEKALVKAIKEGKL 254
+LL D V L L + +H+IN+ VK++ +G +LVN RG L+DEKAL +A+KEG++
Sbjct: 225 DLLFHSDCVTLHCGLNEHNHHLINDFTVKQMRQGAFLVNTARGGLVDEKALAQALKEGRI 284
Query: 255 KGFATDVFEEEPVK-EHELFRFKWETVLTPHYAGLGKDVLEDMGFRAVENLLKVLRGEIP 313
+G A DV E EP + + TPH A + +M A + + + G IP
Sbjct: 285 RGAALDVHESEPFSFSQGPLKDAPNLICTPHAAWYSEQASIEMREEAAREIRRAITGRIP 344
Query: 314 EDLVN 318
+ L N
Sbjct: 345 DSLKN 349
>gi|4557497 C-terminal binding protein 1 [Homo sapiens]
>gi|11436083|ref|XP_003445.1| C-terminal binding protein
1 [Homo sapiens] >gi|6014741|sp|Q13363|CTB1_HUMAN
C-TERMINAL BINDING PROTEIN 1 (CTBP1)
>gi|3702075|gb|AAC62822.1| (U37408) phosphoprotein CtBP
[Homo sapiens] >gi|4262370|gb|AAD14597.1| (AF091555)
C-terminal binding protein [Homo sapiens]
Length = 440
Score = 143 bits (358), Expect = 2e-33
Identities = 91/305 (29%), Positives = 157/305 (50%), Gaps = 5/305 (1%)
Query: 19 LKKYTDVVLKPYPSEEELKE-IIPELDGIIIAPVTRITKDILERAERLKVISCQSAGYDH 77
LK V S +E+ E ++ E G ++ +T++ LE+ + L++I +G+D+
Sbjct: 45 LKDVATVAFCDAQSTQEIHEKVLNEAVGALMYHTITLTREDLEKFKALRIIVRIGSGFDN 104
Query: 78 VDVEEATKRGIYVTKVSGLLSEAVAEFALGLLISLMRKIHYADSFIREGKWESHTFVWRE 137
+D++ A GI V V E A+ L +++L R+ + +REG RE
Sbjct: 105 IDIKSAGDLGIAVCNVPAASVEETADSTLCHILNLYRRATWLHQALREGTRVQSVEQIRE 164
Query: 138 FKE-VETLYGKEVGIVGMGAIGKAIARRLKPFGCEIYYWSRHRKEDIEREVNAKYLD-LD 195
+ G+ +GI+G+G +G+A+A R K FG + ++ + + +ER + + + L
Sbjct: 165 VASGAARIRGETLGIIGLGRVGQAVALRAKAFGFNVLFYDPYLSDGVERALGLQRVSTLQ 224
Query: 196 ELLEEVDIVILALPLTKETYHIINEERVKKL-EGKYLVNIGRGALIDEKALVKAIKEGKL 254
+LL D V L L + +H+IN+ VK++ +G +LVN RG L+DEKAL +A+KEG++
Sbjct: 225 DLLFHSDCVTLHCGLNEHNHHLINDFTVKQMRQGAFLVNTARGGLVDEKALAQALKEGRI 284
Query: 255 KGFATDVFEEEPVK-EHELFRFKWETVLTPHYAGLGKDVLEDMGFRAVENLLKVLRGEIP 313
+G A DV E EP + + TPH A + +M A + + + G IP
Sbjct: 285 RGAALDVHESEPFSFSQGPLKDAPNLICTPHAAWYSEQASIEMREEAAREIRRAITGRIP 344
Query: 314 EDLVN 318
+ L N
Sbjct: 345 DSLKN 349
>gi|9506527 C-terminal binding protein 1 [Rattus norvegicus]
>gi|3925357|gb|AAC79427.1| (AF067795) BFA-dependent
ADP-ribosylation substrate BARS50 [Rattus norvegicus]
Length = 430
Score = 143 bits (357), Expect = 3e-33
Identities = 92/305 (30%), Positives = 157/305 (51%), Gaps = 5/305 (1%)
Query: 19 LKKYTDVVLKPYPSEEELKE-IIPELDGIIIAPVTRITKDILERAERLKVISCQSAGYDH 77
LK V S +E+ E ++ E G ++ +T++ LE+ + L++I +G+D+
Sbjct: 34 LKDVATVAFCDAQSTQEIHEKVLNEAVGALMYHTITLTREDLEKFKALRIIVRIGSGFDN 93
Query: 78 VDVEEATKRGIYVTKVSGLLSEAVAEFALGLLISLMRKIHYADSFIREGKWESHTFVWRE 137
+D++ A GI V V E A+ L +++L R+ + +REG RE
Sbjct: 94 IDIKSAGDLGIAVCNVPAASVEETADSTLCHILNLYRRTTWLHQALREGTRVQSVEQIRE 153
Query: 138 FKE-VETLYGKEVGIVGMGAIGKAIARRLKPFGCEIYYWSRHRKEDIEREVNAKYLD-LD 195
+ G+ +GI+G+G +G+A+A R K FG + ++ + + IER + + + L
Sbjct: 154 VASGAARIRGETLGIIGLGRVGQAVALRAKAFGFNVLFYDPYLSDGIERALGLQRVSTLQ 213
Query: 196 ELLEEVDIVILALPLTKETYHIINEERVKKL-EGKYLVNIGRGALIDEKALVKAIKEGKL 254
+LL D V L L + +H+IN+ VK++ +G +LVN RG L+DEKAL +A+KEG++
Sbjct: 214 DLLFHSDCVTLHCGLNEHNHHLINDFTVKQMRQGAFLVNTARGGLMDEKALAQALKEGRI 273
Query: 255 KGFATDVFEEEPVK-EHELFRFKWETVLTPHYAGLGKDVLEDMGFRAVENLLKVLRGEIP 313
+G A DV E EP + + TPH A + +M A + + + G IP
Sbjct: 274 RGAALDVHESEPFSFSQGPLKDAPNLICTPHAAWYSEQASIEMREEAAREIRRAITGRIP 333
Query: 314 EDLVN 318
+ L N
Sbjct: 334 DSLKN 338
>gi|4557499 C-terminal binding protein 2 [Homo sapiens]
>gi|11432544|ref|XP_005960.1| similar to C-terminal
binding protein 2 (H. sapiens) [Homo sapiens]
>gi|3182976|sp|P56545|CTB2_HUMAN C-TERMINAL BINDING
PROTEIN 2 >gi|2909777|gb|AAC39603.1| (AF016507)
C-terminal binding protein 2 [Homo sapiens]
Length = 445
Score = 142 bits (355), Expect = 5e-33
Identities = 95/310 (30%), Positives = 161/310 (51%), Gaps = 8/310 (2%)
Query: 19 LKKYTDVVLKPYPSEEELKE-IIPELDGIIIAPVTRITKDILERAERLKVISCQSAGYDH 77
LK V S +E+ E ++ E G ++ +T++ LE+ + L+VI +GYD+
Sbjct: 51 LKDLATVAFCDAQSTQEIHEKVLNEAVGAMMYHTITLTREDLEKFKALRVIVRIGSGYDN 110
Query: 78 VDVEEATKRGIYVTKVSGLLSEAVAEFALGLLISLMRKIHYADSFIREGKWESHTFVWRE 137
VD++ A + GI V + E A+ + +++L R+ + +REG RE
Sbjct: 111 VDIKAAGELGIAVCNIPSAAVEETADSTICHILNLYRRNTWLYQALREGTRVQSVEQIRE 170
Query: 138 FKE-VETLYGKEVGIVGMGAIGKAIARRLKPFGCEIYYWSRHRKEDIEREVNAKYL-DLD 195
+ G+ +G++G G G+A+A R K FG + ++ + ++ IER + + + L
Sbjct: 171 VASGAARIRGETLGLIGFGRTGQAVAVRAKAFGFSVIFYDPYLQDGIERSLGVQRVYTLQ 230
Query: 196 ELLEEVDIVILALPLTKETYHIINEERVKKL-EGKYLVNIGRGALIDEKALVKAIKEGKL 254
+LL + D V L L + +H+IN+ +K++ +G +LVN RG L+DEKAL +A+KEG++
Sbjct: 231 DLLYQSDCVSLHCNLNEHNHHLINDFTIKQMRQGAFLVNAARGGLVDEKALAQALKEGRI 290
Query: 255 KGFATDVFEEEPVK-EHELFRFKWETVLTPHYAGLGKDVLEDMGFRAVENLLKVLRGEIP 313
+G A DV E EP + + TPH A + +M A + + + G IP
Sbjct: 291 RGAALDVHESEPFSFAQGPLKDAPNLICTPHTAWYSEQASLEMREAAATEIRRAITGRIP 350
Query: 314 EDL---VNKE 320
E L VNKE
Sbjct: 351 ESLRNCVNKE 360
>gi|6753548 C-terminal binding protein 2 [Mus musculus]
>gi|3513571|gb|AAC33873.1| (AF059735) C-terminal binding
protein 2 CtBP2 [Mus musculus]
>gi|6015476|dbj|BAA85181.1| (AB033123) C-terminal
binding protein 2 [Mus musculus]
Length = 445
Score = 142 bits (354), Expect = 6e-33
Identities = 95/310 (30%), Positives = 161/310 (51%), Gaps = 8/310 (2%)
Query: 19 LKKYTDVVLKPYPSEEELKE-IIPELDGIIIAPVTRITKDILERAERLKVISCQSAGYDH 77
LK V S +E+ E ++ E G ++ +T++ LE+ + L+VI +GYD+
Sbjct: 51 LKDLATVAFCDAQSTQEIHEKVLNEAVGAMMYHTITLTREDLEKFKALRVIVRIGSGYDN 110
Query: 78 VDVEEATKRGIYVTKVSGLLSEAVAEFALGLLISLMRKIHYADSFIREGKWESHTFVWRE 137
VD++ A + GI V + E A+ + +++L R+ + +REG RE
Sbjct: 111 VDIKAAGELGIAVCNIPSAAVEETADSTVCHILNLYRRNTWLYQALREGTRVQSVEQIRE 170
Query: 138 FKE-VETLYGKEVGIVGMGAIGKAIARRLKPFGCEIYYWSRHRKEDIEREVNAKYL-DLD 195
+ G+ +G++G G G+A+A R K FG + ++ + ++ IER + + + L
Sbjct: 171 VASGAARIRGETLGLIGFGRTGQAVAVRAKAFGFSVIFYDPYLQDGIERSLGVQRVYTLQ 230
Query: 196 ELLEEVDIVILALPLTKETYHIINEERVKKL-EGKYLVNIGRGALIDEKALVKAIKEGKL 254
+LL + D V L L + +H+IN+ +K++ +G +LVN RG L+DEKAL +A+KEG++
Sbjct: 231 DLLYQSDCVSLHCNLNEHNHHLINDFTIKQMRQGAFLVNAARGGLVDEKALAQALKEGRI 290
Query: 255 KGFATDVFEEEPVK-EHELFRFKWETVLTPHYAGLGKDVLEDMGFRAVENLLKVLRGEIP 313
+G A DV E EP + + TPH A + +M A + + + G IP
Sbjct: 291 RGAALDVHESEPFSFAQGPLKDAPNLICTPHTAWYSEQASLEMREAAATEIRRAITGRIP 350
Query: 314 EDL---VNKE 320
E L VNKE
Sbjct: 351 ESLRNCVNKE 360
>pir||T19602 hypothetical protein C31C9.2 - Caenorhabditis elegans
>gi|3874647|emb|CAB05694.1| (Z83219) contains similarity
to Pfam domain: PF00389 (D-isomer specific 2-hydroxyacid
dehydrogenases), Score=247.0, E-value=2.5e-101, N=1~cDNA
EST EMBL:T00729 comes from this gene~cDNA EST yk636a9.3
comes from this gene~cDNA EST yk636a9.5 comes from th>
Length = 322
Score = 141 bits (352), Expect = 1e-32
Identities = 86/301 (28%), Positives = 158/301 (51%), Gaps = 9/301 (2%)
Query: 24 DVVLKPYPSEEELKEIIPELDGIIIAPVTRITKDILER-AERLKVISCQSAGYDHVDVEE 82
+V +K +++EL +P+ D +I+ T+IT ++L A +LK++ G D++DV
Sbjct: 28 EVTVKTKQTKDELLVTLPQHDAVIVRSATKITAELLAASAGKLKLVGRAGTGVDNIDVPA 87
Query: 83 ATKRGIYVTKVSGLLSEAVAEFALGLLISLMRKIHYADSFIREGKWESHTFVWREFKEVE 142
A+ I V S + AE L++SL R + A + ++ GKW F+ E
Sbjct: 88 ASANKILVMNTPQANSRSAAELTCTLILSLSRHVPQAAASMKAGKWARKDFMGEE----- 142
Query: 143 TLYGKEVGIVGMGAIGKAIARRLKPFGCEIYYWSRHRKEDIEREVNAKYLDLDELLEEVD 202
+YG+ + ++G+G IG +A RL+ FG ++ + ++ N + L L+++ + D
Sbjct: 143 -VYGRTLAVLGLGRIGSEVAVRLQAFGMKVIGFDPMVTKEQAEAKNIELLSLEQIWPQAD 201
Query: 203 IVILALPLTKETYHIINEERVKKL-EGKYLVNIGRGALIDEKALVKAIKEGKLKGFATDV 261
+ + +PL K+T ++IN+E + K +G ++N+ RG +++E LV+++ G KG A DV
Sbjct: 202 YITVHVPLIKQTENLINKETLAKCKKGVRIINVARGGIVNEVDLVESLNAGHAKGAAFDV 261
Query: 262 FEEEPVKEHELFRFKWETVLTPHYAGLGKDVLEDMGFRAVENLLKVLRGEIPEDLVNKEV 321
FE+EP EL + TPH D + +N+++ +G + L +EV
Sbjct: 262 FEQEPPTFRELIDHPL-VIATPHLGASTIDAQLRVASEIADNIVQYNKGTMLGVLNAREV 320
Query: 322 L 322
L
Sbjct: 321 L 321
>gb|AAD41370.1|AF152006_1 (AF152006) Tcf-3 co-repressor CtBP [Xenopus laevis]
Length = 437
Score = 141 bits (352), Expect = 1e-32
Identities = 90/312 (28%), Positives = 163/312 (51%), Gaps = 8/312 (2%)
Query: 19 LKKYTDVVLKPYPSEEELKE-IIPELDGIIIAPVTRITKDILERAERLKVISCQSAGYDH 77
LK V S +E+ E ++ E G ++ ++++ LE+ + L++I +GYD+
Sbjct: 48 LKDVATVAFCDAQSTQEIHEKVLSEAVGALMYHTITLSREDLEKFKALRIIIKIGSGYDN 107
Query: 78 VDVEEATKRGIYVTKVSGLLSEAVAEFALGLLISLMRKIHYADSFIREGKWESHTFVWRE 137
+D++ A + GI V + E A+ L +++L R++ + +REG + RE
Sbjct: 108 IDIKSAAELGIAVCNIPSASVEETADSTLCHILNLYRRVTWLHQAMREGNRPASVEQIRE 167
Query: 138 FKE-VETLYGKEVGIVGMGAIGKAIARRLKPFGCEIYYWSRHRKEDIEREVNAKYL-DLD 195
+ G+ +GI+G+G IG+A+A R K F + ++ + + +ER + + + L
Sbjct: 168 VAGGAARIRGETLGIIGLGRIGQAVALRAKAFNFTVIFYDPYLADGVERSLGLQRMATLQ 227
Query: 196 ELLEEVDIVILALPLTKETYHIINEERVKKL-EGKYLVNIGRGALIDEKALVKAIKEGKL 254
ELL D + L L + +H+IN+ +K++ +G +LVN RG L+DEKAL +A+K+G++
Sbjct: 228 ELLMHSDCITLHCNLNEHNHHLINDFTIKQMRQGCFLVNTARGGLVDEKALAQALKDGRI 287
Query: 255 KGFATDVFEEEPVK-EHELFRFKWETVLTPHYAGLGKDVLEDMGFRAVENLLKVLRGEIP 313
+G A DV E EP + + TPH A + + A + + + + G IP
Sbjct: 288 RGAALDVHESEPFSFSQGPLKDAPNLICTPHTAWYSEHASIEAREEAAKEIRRAIAGPIP 347
Query: 314 EDL---VNKEVL 322
+ L VNK+ L
Sbjct: 348 DSLRNCVNKDYL 359
>sp|P43885|SERA_HAEIN D-3-PHOSPHOGLYCERATE DEHYDROGENASE (PGDH) >gi|1075144|pir||C64070
phosphoglycerate dehydrogenase (EC 1.1.1.95) -
Haemophilus influenzae (strain Rd KW20)
>gi|1573443|gb|AAC22124.1| (U32729) D-3-phosphoglycerate
dehydrogenase (serA) [Haemophilus influenzae Rd]
Length = 410
Score = 140 bits (349), Expect = 2e-32
Identities = 92/282 (32%), Positives = 148/282 (51%), Gaps = 21/282 (7%)
Query: 34 EELKEIIPELDGIIIAPVTRITKDILERAERLKVISCQSAGYDHVDVEEATKRGIYVTKV 93
+ELKE I ++ I + T +T +++E A +L + C G + VD+ A RGI V
Sbjct: 46 DELKEAIKDVHFIGLRSRTHLTAEMIEAAPKLIAVGCFCIGTNQVDLNAAKARGIPVFNA 105
Query: 94 SGLLSEAVAEFALGLLISLMRKIHYADSFIREGKWESHTFVWREFKEVETLYGKEVGIVG 153
+ +VAE LG ++ LMR + A++ + G W E + GK++GI+G
Sbjct: 106 PFSNTRSVAELVLGEILLLMRNVPQANAEVHRGVWNKSATGSHEVR------GKKLGIIG 159
Query: 154 MGAIGKAIARRLKPFGCEIYYWSRHRKEDIEREV---NAKYL-DLDELLEEVDIVILALP 209
G IG ++ + G ++Y++ DIE ++ NAK + L+ELL D+V L +P
Sbjct: 160 YGHIGSQLSIIAESLGMDVYFY------DIENKLPLGNAKQVRSLEELLSSCDVVSLHVP 213
Query: 210 LTKETYHIINEERVKKL-EGKYLVNIGRGALIDEKALVKAIKEGKLKGFATDVFEEEPVK 268
T +++N R+ +L +G L+N RG ++D AL +A+K+GKL+G A DVF EP
Sbjct: 214 ELPSTKNLMNVARIAQLKQGAILINAARGTVVDIDALAQALKDGKLQGAAIDVFPVEPAS 273
Query: 269 EHELF----RFKWETVLTPHYAGLGKDVLEDMGFRAVENLLK 306
+E F R +LTPH G + E++GF +K
Sbjct: 274 INEEFISPLREFDNVILTPHIGGSTAEAQENIGFEVAGKFVK 315
>gb|AAF53929.1| (AE003668) CG9331 gene product [Drosophila melanogaster]
Length = 248
Score = 140 bits (349), Expect = 2e-32
Identities = 87/243 (35%), Positives = 129/243 (52%), Gaps = 6/243 (2%)
Query: 72 SAGYDHVDVEEATKRGIYVTKVSGLLSEAVAEFALGLLISLMRKIHYADSFIREGKWESH 131
SAG D+VDV E +R I + +L+ AVA+ A+GLLI+ R+ H I KWE++
Sbjct: 2 SAGIDYVDVPEVKRRKIPLGHTPTVLNTAVADLAVGLLIAASRRFHEGRKTIDNDKWENY 61
Query: 132 TFVWREFKEVETLYGKEVGIVGMGAIGKAIARRLKPFGCE-IYYWSRHR-KEDIEREVNA 189
W +++ VG G G IG+AIA+RL F + + Y +R R ++IE E NA
Sbjct: 62 HLNWLLGQDIR---DSTVGFYGFGGIGQAIAKRLSGFDIDKVLYTTRRRVHKEIEEEFNA 118
Query: 190 KYLDLDELLEEVDIVILALPLTKETYHIINEERVKKL-EGKYLVNIGRGALIDEKALVKA 248
K +D D LL E D V++A PLTK+T + N K+ + LVNI RG ++++ L +A
Sbjct: 119 KKVDFDTLLAESDFVVIASPLTKDTQGVFNATAFNKMKQTAVLVNIARGKIVNQDDLYEA 178
Query: 249 IKEGKLKGFATDVFEEEPVKEHELFRFKWETVLTPHYAGLGKDVLEDMGFRAVENLLKVL 308
+K ++ DV + EP+ + V+ PH K DM A N+L+ L
Sbjct: 179 LKANRIFSAGLDVTDPEPLSPKDKLLTLDNVVVLPHIGSATKRTRADMSTIAAHNVLRGL 238
Query: 309 RGE 311
GE
Sbjct: 239 AGE 241
>gi|6912396 glyoxylate reductase/hydroxypyruvate reductase [Homo sapiens]
>gi|11428924|ref|XP_005487.1| glyoxylate
reductase/hydroxypyruvate reductase [Homo sapiens]
>gi|5639830|gb|AAD45886.1|AF146018_1 (AF146018)
hydroxypyruvate reductase [Homo sapiens]
>gi|5669919|gb|AAD46517.1|AF146689_1 (AF146689)
hydroxypyruvate reductase [Homo sapiens]
>gi|6002730|gb|AAF00111.1|AF134895_1 (AF134895)
glyoxylate reductase [Homo sapiens]
Length = 328
Score = 139 bits (348), Expect = 3e-32
Identities = 106/333 (31%), Positives = 166/333 (49%), Gaps = 24/333 (7%)
Query: 1 MKP-RIGVLFKMKSKPLE---ELKKYTDVVLKPYPSEE-----ELKEIIPELDGIIIAPV 51
M+P R+ +F + P E L + D ++ + S+E EL+ + G++
Sbjct: 1 MRPVRLMKVFVTRRIPAEGRVALARAADCEVEQWDSDEPIPAKELERGVAGAHGLLCLLS 60
Query: 52 TRITKDILERA-ERLKVISCQSAGYDHVDVEEATKRGIYVTKVSGLLSEAVAEFALGLLI 110
+ K IL+ A LKVIS S G DH+ ++E KRGI V +L++ AE A+ LL+
Sbjct: 61 DHVDKRILDAAGANLKVISTMSVGIDHLALDEIKKRGIRVGYTPDVLTDTTAELAVSLLL 120
Query: 111 SLMRKIHYADSFIREGKWESHTFVWREFKEVETLYG---KEVGIVGMGAIGKAIARRLKP 167
+ R++ A ++ G W S +W YG VGI+G+G IG+AIARRLKP
Sbjct: 121 TTCRRLPEAIEEVKNGGWTSWKPLWL------CGYGLTQSTVGIIGLGRIGQAIARRLKP 174
Query: 168 FGCEIY-YWSRHRKEDIEREVNAKYLDLDELLEEVDIVILALPLTKETYHIINEERVKKL 226
FG + + Y R + + E A+++ EL + D +++A LT T + N++ +K+
Sbjct: 175 FGVQRFLYTGRQPRPEEAAEFQAEFVSTPELAAQSDFIVVACSLTPATEGLCNKDFFQKM 234
Query: 227 -EGKYLVNIGRGALIDEKALVKAIKEGKLKGFATDVFEEEPV-KEHELFRFKWETVLTPH 284
E +NI RG ++++ L +A+ GK+ DV EP+ H L K V+ PH
Sbjct: 235 KETAVFINISRGDVVNQDDLYQALASGKIAAAGLDVTSPEPLPTNHPLLTLK-NCVILPH 293
Query: 285 YAGLGKDVLEDMGFRAVENLLKVLRGE-IPEDL 316
M A NLL LRGE +P +L
Sbjct: 294 IGSATHRTRNTMSLLAANNLLAGLRGEPMPSEL 326
>sp|Q61753|SERA_MOUSE D-3-PHOSPHOGLYCERATE DEHYDROGENASE (PGDH) (A10)
>gi|986918|gb|AAB67986.1| (L21027) A10 [Mus musculus]
Length = 485
Score = 139 bits (348), Expect = 3e-32
Identities = 79/280 (28%), Positives = 145/280 (51%), Gaps = 8/280 (2%)
Query: 44 DGIIIAPVTRITKDILERAERLKVISCQSAGYDHVDVEEATKRGIYVTKVSGLLSEAVAE 103
+G+I+ T++T D++ AE+L+V+ G D+VD+E T++GI V S + AE
Sbjct: 1 EGLIVRSATKVTADVINAAEKLQVVGRAVTGVDNVDLEPPTRKGILVMNTPNGNSLSAAE 60
Query: 104 FALGLLISLMRKIHYADSFIREGKWESHTFVWREFKEVETLYGKEVGIVGMGAIGKAIAR 163
G+++ L R+I + +++GKW+ F+ E L GK +GI+G+G IG+ +A
Sbjct: 61 LTCGMIMCLARQIPQTTASMKDGKWDRKKFMGTE------LNGKTLGILGLGRIGREVAT 114
Query: 164 RLKPFGCEIYYWSRHRKEDIEREVNAKYLDLDELLEEVDIVILALPLTKETYHIINEERV 223
R++ FG + + ++ + L L+E+ D + + PL T ++N+
Sbjct: 115 RMQSFGMKTVGYDPIISPEVAASFGVQQLPLEEIWPLCDFITVHTPLLPSTTGLLNDSTF 174
Query: 224 KKL-EGKYLVNIGRGALIDEKALVKAIKEGKLKGFATDVFEEEPVKEHELFRFKWETVLT 282
+ +G +VN RG ++DE AL++A++ G+ G A DVF EEP ++ L + +
Sbjct: 175 AQCKKGVRVVNCARGGIVDEGALLRALQSGQCAGAALDVFTEEPPRDRALVDHE-NVISC 233
Query: 283 PHYAGLGKDVLEDMGFRAVENLLKVLRGEIPEDLVNKEVL 322
PH K+ G + +++G+ +VN + L
Sbjct: 234 PHLGASTKEAQSRCGEEIAVQFVDMVKGKSLTGVVNAQAL 273
>dbj|BAA77337.1| (AB019533) Nad-dependent formate dehydrogenase [Oryza sativa]
Length = 376
Score = 139 bits (348), Expect = 3e-32
Identities = 80/258 (31%), Positives = 147/258 (56%), Gaps = 9/258 (3%)
Query: 35 ELKEIIPELDGIIIAPV--TRITKDILERAERLKVISCQSAGYDHVDVEEATKRGIYVTK 92
EL++ I ++ +I P ++ + +++A+ L+++ G DH+D+ A G+ V +
Sbjct: 80 ELEKHIEDMHVLITTPFHPAYVSAERIKKAKNLELLLTAGIGSDHIDLPAAAAAGLTVAE 139
Query: 93 VSGLLSEAVAEFALGLLISLMRKIHYADSFIREGKWESHTFVWREFKEVETLYGKEVGIV 152
V+G + +VAE L ++ L+R + G+W +R + L GK VG V
Sbjct: 140 VTGSNTVSVAEDELMRILILLRNFLPGYQQVVHGEWNVAGIAYRAYD----LEGKTVGTV 195
Query: 153 GMGAIGKAIARRLKPFGCEIYYWSRHRKE-DIEREVNAKYL-DLDELLEEVDIVILALPL 210
G G IG+ + +RLKPF C + Y R + + ++E+E+ AKY DLD +L + D++++ PL
Sbjct: 196 GAGRIGRLLLQRLKPFNCNLLYHDRLKIDPELEKEIGAKYEEDLDAMLPKCDVIVINTPL 255
Query: 211 TKETYHIINEERVKKLE-GKYLVNIGRGALIDEKALVKAIKEGKLKGFATDVFEEEPVKE 269
T++T + N+ER+ K++ G +VN RGA++D +A+ A G++ G+ DV+ +P +
Sbjct: 256 TEKTRGMFNKERIAKMKKGVIIVNNARGAIMDTQAVADACSSGQVAGYGGDVWFPQPAPK 315
Query: 270 HELFRFKWETVLTPHYAG 287
+R+ +TPH +G
Sbjct: 316 GPPWRYMPNHAMTPHISG 333
>sp|P44501|DDH_HAEIN 2-HYDROXYACID DEHYDROGENASE HOMOLOG >gi|1073777|pir||F64047
D-2-hydroxy-acid dehydrogenase (EC 1.1.99.6) -
Haemophilus influenzae (strain Rd KW20)
>gi|1573036|gb|AAC21763.1| (U32694) D-lactate
dehydrogenase, fermentative (ldhA) [Haemophilus
influenzae Rd]
Length = 331
Score = 139 bits (347), Expect = 4e-32
Identities = 88/279 (31%), Positives = 152/279 (53%), Gaps = 23/279 (8%)
Query: 55 TKDILERAERL--KVISCQSAGYDHVDVEEATKRGIYVTKVSGLLSEAVAEFALGLLISL 112
++ +LE+ L K+++ + AG+++VD++ A + GI V +V EAVAE +GL+++L
Sbjct: 57 SRKVLEKLAALGVKIVALRCAGFNNVDLKAAQELGIQVVRVPAYSPEAVAEHTIGLMMTL 116
Query: 113 MRKIHYADSFIREGKWESHTFVWREFKEVETLYGKEVGIVGMGAIGKAIARRLKPFGCEI 172
R+IH A RE + + +YG+ VG++G G IG A+ R LK FG I
Sbjct: 117 NRRIHRAYQRTREANFSLEGLIG------FNMYGRTVGVIGTGKIGIAVMRILKGFGMNI 170
Query: 173 YYWSRHRKEDIEREVNAKYLDLDELLEEVDIVILALPLTKETYHIINEERVKKL-EGKYL 231
+ + +E E+ +Y++LDEL + ++ L P T E YH++N E K+ +G +
Sbjct: 171 LAYDPFKNPVVE-ELGGQYVELDELYAKSHVITLHCPATPENYHLLNCEAFAKMKDGVMI 229
Query: 232 VNIGRGALIDEKALVKAIKEGKLKGFATDVFEEE----------PVKEHELFR---FKWE 278
VN RG+LID +A + A+K+ K+ DV+E E V + ++FR
Sbjct: 230 VNTSRGSLIDTQAAIDALKQRKIGALGMDVYENERDLFFEDKSNEVIQDDIFRRLSSCHN 289
Query: 279 TVLTPHYAGLGKDVLEDMGFRAVENLLKVLRGEIPEDLV 317
+LT H A L ++ L ++ + N+ K+ G++ E++V
Sbjct: 290 VLLTGHQAFLTEEALTNIADVTLSNIYKLKSGKVCENIV 328
>gi|6324055 Ynl274cp [Saccharomyces cerevisiae]
>gi|1730640|sp|P53839|YN14_YEAST HYPOTHETICAL 38.8 KD
PROTEIN IN MET2-SEC2 INTERGENIC REGION
>gi|2131951|pir||S63248 hypothetical protein YNL274c -
yeast (Saccharomyces cerevisiae)
>gi|1302340|emb|CAA96182.1| (Z71550) ORF YNL274c
[Saccharomyces cerevisiae]
Length = 350
Score = 139 bits (346), Expect = 5e-32
Identities = 101/307 (32%), Positives = 151/307 (48%), Gaps = 19/307 (6%)
Query: 18 ELKKYTDVVLKPYPSEEE--LKEIIPELDGI----IIAPVTRITKDILERAERLK----- 66
EL+K DV+ P + E L+E+ + + +I R K+ E L
Sbjct: 22 ELEKIADVITIPESTTREQFLREVKDPQNKLSQVQVITRTARSVKNTGRFDEELALALPS 81
Query: 67 --VISCQS-AGYDHVDVEEATKRGIYVTKVSGLLSEAVAEFALGLLISLMRKIHYADSFI 123
V C + AGYD +DVE KR I V V L+S A A+ + LL+ +R + +
Sbjct: 82 SVVAVCHTGAGYDQIDVEPFKKRHIQVANVPDLVSNATADTHVFLLLGALRNFGIGNRRL 141
Query: 124 REGKW-ESHTFVWREFKEVETLYGKEVGIVGMGAIGKAIARRLKPFGCEIYYWSRHRKED 182
EG W E+ F GK VGI+G+G IG+ I RLKPFG E + + +
Sbjct: 142 IEGNWPEAGPACGSPFGYDPE--GKTVGILGLGRIGRCILERLKPFGFENFIYHNRHQLP 199
Query: 183 IEREVNAKYLDLDELLEEVDIVILALPLTKETYHIINEERVKKL-EGKYLVNIGRGALID 241
E E +Y+ +E L+ DIV + +PL T+H+IN E ++K+ +G +VN RGA+ID
Sbjct: 200 SEEEHGCEYVGFEEFLKRSDIVSVNVPLNHNTHHLINAETIEKMKDGVVIVNTARGAVID 259
Query: 242 EKALVKAIKEGKLKGFATDVFEEEPVKEHELFRFKWETVLTPHYAGLGKDVLEDMGFRAV 301
E+A+ A++ GK++ DVFE EP EL + + PH + + M V
Sbjct: 260 EQAMTDALRSGKIRSAGLDVFEYEPKISKELLSMS-QVLGLPHMGTHSVETRKKMEELVV 318
Query: 302 ENLLKVL 308
EN V+
Sbjct: 319 ENAKNVI 325
>sp|P56546|CTB2_MOUSE C-TERMINAL BINDING PROTEIN 2 >gi|2909779|gb|AAC40043.1| (AF016508)
C-terminal binding protein 2 [Mus musculus]
Length = 420
Score = 138 bits (345), Expect = 7e-32
Identities = 93/310 (30%), Positives = 160/310 (51%), Gaps = 8/310 (2%)
Query: 19 LKKYTDVVLKPYPSEEELKE-IIPELDGIIIAPVTRITKDILERAERLKVISCQSAGYDH 77
LK V S +E+ E ++ E G ++ +T++ LE+ + L+VI +GYD+
Sbjct: 26 LKDLATVAFCDAQSTQEIHEKVLNEAVGAMMYHTITLTREDLEKFKALRVIVRIGSGYDN 85
Query: 78 VDVEEATKRGIYVTKVSGLLSEAVAEFALGLLISLMRKIHYADSFIREGKWESHTFVWRE 137
VD++ A + GI V + E A+ + +++L R+ + +REG R+
Sbjct: 86 VDIKAAGELGIAVCNIPSAAVEETADSTVCHILNLYRRNTWLYQALREGTRVQSVEQIRD 145
Query: 138 FKE-VETLYGKEVGIVGMGAIGKAIARRLKPFGCEIYYWSRHRKEDIEREVNAKYL-DLD 195
+ G+ +G++G G G+A+A R K FG + ++ + ++ IER + + + L
Sbjct: 146 VASGAARIRGETLGLIGFGRTGQAVAVRAKAFGFSVIFYDPYLQDGIERSLGVQRVYTLQ 205
Query: 196 ELLEEVDIVILALPLTKETYHIINEERVKKL-EGKYLVNIGRGALIDEKALVKAIKEGKL 254
+LL + D V L L + +H+IN+ +K++ +G +LVN RG L+DEKAL +A+KE ++
Sbjct: 206 DLLYQSDCVSLHCNLNEHNHHLINDFTIKQMRQGAFLVNAARGGLVDEKALAQALKEARI 265
Query: 255 KGFATDVFEEEPVK-EHELFRFKWETVLTPHYAGLGKDVLEDMGFRAVENLLKVLRGEIP 313
+G A DV E EP + + TPH A + +M A + + + G IP
Sbjct: 266 RGAALDVHESEPFSFAQGPLKDAPNLICTPHTAWYSEQASLEMREAAATEIRRAITGRIP 325
Query: 314 EDL---VNKE 320
E L VNKE
Sbjct: 326 ESLRNCVNKE 335
>pir||H64531 phosphoglycerate dehydrogenase - Helicobacter pylori (strain 26695)
>gi|2313177|gb|AAD07165.1| (AE000531) phosphoglycerate
dehydrogenase [Helicobacter pylori 26695]
Length = 314
Score = 137 bits (342), Expect = 2e-31
Identities = 96/315 (30%), Positives = 171/315 (53%), Gaps = 17/315 (5%)
Query: 6 GVLFKMKS---KPLEELKKYTDVVLKPYPSEEELKEIIPELDGIIIAPVTRITKDILERA 62
GV+ KS K LE LK+ D ++ E E + +++ V IT+++L +
Sbjct: 7 GVILDAKSVGLKALEVLKEVADFDFYEVTPPSQIVERSIEAEIMVLNKVV-ITQEVLSQL 65
Query: 63 ERLKVISCQSAGYDHVDVEEATKRGIYVTKVSGLLSEAVAEFALGLLISLMRKIHYADSF 122
+LK+I + G D+VD++ A GI V VS +E+VA+ L +SL+ +I+ D +
Sbjct: 66 PKLKLICITATGTDNVDIKSAKALGIEVKNVSAYSTESVAQHTLACALSLLGRINDYDRY 125
Query: 123 IREGKW-ESHTFVWREFKEVETLYGKEVGIVGMGAIGKAIARRLKPFGCEIYYWS-RHRK 180
+ G++ +S F ++ + G + G++G+G IGK +A+ + FG ++ Y+S + +K
Sbjct: 126 CKSGEYSQSDLFTHISDIKMGLIKGSQWGVIGLGTIGKRVAKLAQAFGAKVVYYSPKDKK 185
Query: 181 EDIEREVNAKYLDLDELLEEVDIVILALPLTKETYHIINEERVKKL-EGKYLVNIGRGAL 239
E+ ER L L +LL DI+ + PL + T +I + ++ L +G L+N+GRG +
Sbjct: 186 EEYER------LSLKDLLATSDIISIHAPLNESTRDLIALKELQSLKDGAILINVGRGGI 239
Query: 240 IDEKALVKAIKEGKLKGFATDVFEEEPVKEHELF---RFKWETVLTPHYAGLGKDVLEDM 296
++EK L + I E K +A+DVF +EP ++ F + + + +LTPH A D L+ +
Sbjct: 240 VNEKDLAE-ILETKDLYYASDVFVKEPFEKDHAFLNPKIQNKLLLTPHIAWAYSDSLKTL 298
Query: 297 GFRAVENLLKVLRGE 311
+ EN+ L +
Sbjct: 299 VEKTKENIQDFLASQ 313
>gb|AAG20511.1| (AE005123) phosphoglycerate dehydrogenase; SerA1 [Halobacterium sp.
NRC-1]
Length = 527
Score = 137 bits (342), Expect = 2e-31
Identities = 75/298 (25%), Positives = 143/298 (47%), Gaps = 6/298 (2%)
Query: 34 EELKEIIPELDGIIIAPVTRITKDILERAERLKVISCQSAGYDHVDVEEATKRGIYVTKV 93
+ L + + + +I+ T +T + E A L +++ G D++D++ AT G+ V
Sbjct: 33 DALLDAVSDAHALIVRSGTAVTDAVFEAAPDLVIVARAGIGVDNIDIDAATDHGVMVANA 92
Query: 94 SGLLSEAVAEFALGLLISLMRKIHYADSFIREGKWESHTFVWREFKEVETLYGKEVGIVG 153
A AE + L + R I A + + G W ++ E L GK +G+VG
Sbjct: 93 PAGNVRAAAEHTVALAFAAARSIPQAHARLDAGSWAKDDYLGTE------LSGKTLGVVG 146
Query: 154 MGAIGKAIARRLKPFGCEIYYWSRHRKEDIEREVNAKYLDLDELLEEVDIVILALPLTKE 213
+G +G+ +A RL G ++ + + ED ++ A+ +D++ + D + + +PLT E
Sbjct: 147 LGRVGQEVATRLDSLGMDLVAYDPYIGEDRAAQLGAELVDIETCVARADFLTIHVPLTDE 206
Query: 214 TYHIINEERVKKLEGKYLVNIGRGALIDEKALVKAIKEGKLKGFATDVFEEEPVKEHELF 273
T +I E + +++G Y++N+ RG ++DE AL A ++G + G A DVF EP+
Sbjct: 207 TDGLIGEAELARMDGGYVINVARGGVVDEDALADAAQDGVIAGAALDVFRTEPLPAASPL 266
Query: 274 RFKWETVLTPHYAGLGKDVLEDMGFRAVENLLKVLRGEIPEDLVNKEVLKVRPIDEVK 331
+ TPH K E++ + ++ L G+ + +N + D ++
Sbjct: 267 HDADSIITTPHLGASTKAAQENVATDTADQVVAALAGDPVVNALNAPSAERSAFDRIR 324
>sp|Q07103|FDH_NEUCR FORMATE DEHYDROGENASE (NAD-DEPENDENT FORMATE DEHYDROGENASE) (FDH)
>gi|539386|pir||A47117 formate dehydrogenase (EC
1.2.1.2) - Neurospora crassa >gi|1321604|gb|AAA99900.1|
(L13964) formate dehydrogenase [Neurospora crassa]
>gi|11595632|emb|CAC18252.1| (AL451018) formate
dehydrogenase [Neurospora crassa]
Length = 375
Score = 137 bits (341), Expect = 2e-31
Identities = 93/278 (33%), Positives = 150/278 (53%), Gaps = 18/278 (6%)
Query: 54 ITKDILERAERLKVISCQSAGYDHVDVEEATKR--GIYVTKVSGLLSEAVAEFALGLLIS 111
+T + L RA++LK+ G DHVD+ A K GI V +V+G +VAE L ++
Sbjct: 75 LTAERLARAKKLKLAVTAGIGSDHVDLNAANKTNGGITVAEVTGSNVVSVAEHVLMTILV 134
Query: 112 LMRKIHYADSFIREGKWESHTFVWREFKEVETLYGKEVGIVGMGAIGKAIARRLKPFGCE 171
L+R A I+EG+W+ EF L GK VG VG+G IG+ + RRLKPF C+
Sbjct: 135 LVRNFVPAHEQIQEGRWDVAEAAKNEFD----LEGKVVGTVGVGRIGERVLRRLKPFDCK 190
Query: 172 --IYYWSRHRKEDIEREVNAKYL-DLDELLEEVDIVILALPLTKETYHIINEERVKKLE- 227
+YY + + E E+ + + DL+E+L + D+V + PL ++T + N+E + K++
Sbjct: 191 ELLYYDYQPLSAEKEAEIGCRRVADLEEMLAQCDVVTINCPLHEKTQGLFNKELISKMKK 250
Query: 228 GKYLVNIGRGALIDEKALVKAIKEGKLKGFATDVFEEEPVKEHELFR-----FKWETVLT 282
G +LVN RGA++ ++ + +A+K G L+G+ DV+ +P + R F +
Sbjct: 251 GSWLVNTARGAIVVKEDVAEALKSGHLRGYGGDVWFPQPAPQDHPLRYAKNPFGGGNAMV 310
Query: 283 PHYAGLGKDVLE--DMGFRA-VENLLKVLRGEIPEDLV 317
PH +G D + G +A +E+ L PEDL+
Sbjct: 311 PHMSGTSLDAQKRYAAGTKAIIESYLSGKHDYRPEDLI 348
>pir||G71974 probable keto-acid dehydrogenase - Helicobacter pylori (strain
J99) >gi|4154596|gb|AAD05669.1| (AE001448) putative
keto-acid dehydrogenase [Helicobacter pylori J99]
Length = 314
Score = 137 bits (341), Expect = 2e-31
Identities = 97/315 (30%), Positives = 172/315 (53%), Gaps = 17/315 (5%)
Query: 6 GVLFKMKS---KPLEELKKYTDVVLKPYPSEEELKEIIPELDGIIIAPVTRITKDILERA 62
GV+ KS K LE LK+ D S ++ E E + +++ V IT+++L +
Sbjct: 7 GVILDAKSVGLKALEVLKEVADFDFYEVTSPNQIVERSIEAEIMVLNKVV-ITQEVLSQL 65
Query: 63 ERLKVISCQSAGYDHVDVEEATKRGIYVTKVSGLLSEAVAEFALGLLISLMRKIHYADSF 122
+LK+I + G D+VD++ A GI V VS +E+VA+ L +SL+ +I+ D +
Sbjct: 66 PKLKLICITATGTDNVDIKSAKALGIEVKNVSAYSTESVAQHTLACALSLLGRINDYDRY 125
Query: 123 IREGKW-ESHTFVWREFKEVETLYGKEVGIVGMGAIGKAIARRLKPFGCEIYYWS-RHRK 180
+ G++ +S F ++ + G + G++G+G IGK +A+ + FG ++ Y+S + +K
Sbjct: 126 CKSGEYSQSDIFTHISDIKMGLIKGGQWGVIGLGNIGKRVAKLAQAFGAKVVYFSPKDKK 185
Query: 181 EDIEREVNAKYLDLDELLEEVDIVILALPLTKETYHIINEERVKKL-EGKYLVNIGRGAL 239
E+ ER L L+ELL+ I+ + PL + T +I + ++ L +G L+N+GRG +
Sbjct: 186 EEYER------LSLEELLKTSGIISIHAPLNESTRDLIALKELQSLKDGAILINVGRGGI 239
Query: 240 IDEKALVKAIKEGKLKGFATDVFEEEPVKEHELF---RFKWETVLTPHYAGLGKDVLEDM 296
++EK L I E K +A+DVF +EP ++ F + + + +LTPH A D L+ +
Sbjct: 240 VNEKDLA-LILETKDLYYASDVFVKEPFEKDHAFLNPKIQNKLLLTPHIAWAYSDSLKTL 298
Query: 297 GFRAVENLLKVLRGE 311
+ EN+ L +
Sbjct: 299 VEKTKENIQDFLASQ 313
>pir||C81380 probable D-2-hydroxyacid dehydrogenase Cj0373 [imported] -
Campylobacter jejuni (strain NCTC 11168)
>gi|6967847|emb|CAB74209.1| (AL139075) putative
D-2-hydroxyacid dehydrogenase [Campylobacter jejuni]
Length = 311
Score = 137 bits (341), Expect = 2e-31
Identities = 78/244 (31%), Positives = 136/244 (54%), Gaps = 8/244 (3%)
Query: 54 ITKDILERAERLKVISCQSAGYDHVDVEEATKRGIYVTKVSGLLSEAVAEFALGLLISLM 113
I KD+++ + LK+I + G +++D+E A ++GI V +G + +V + + + +
Sbjct: 53 IDKDVIDACKNLKLILETATGVNNIDIEYAKEKGIIVKNAAGYSTMSVVQHTFAFMFAFL 112
Query: 114 RKIHYADSFIREGKWESHTFVWREFKEVETLYGKEVGIVGMGAIGKAIARRLKPFGCEIY 173
++ Y D + +EGKW + + TL GK+ GI+G+G IGK +A+ K FG EIY
Sbjct: 113 NQVLYYDKWSKEGKWCESPIFTDYSRILNTLSGKKHGIIGLGTIGKEVAKISKAFGAEIY 172
Query: 174 YWSRHRKEDIEREVNAKYLDLDELLEEVDIVILALPLTKETYHIINEERVKKL-EGKYLV 232
Y+S + + +L+L +LL+ DI+ + PL ++T +++ E +K L + L+
Sbjct: 173 YYS---TSGANKNADFVHLELKDLLKTCDIISIHAPLNEKTKNLLAFEELKLLKDNAILI 229
Query: 233 NIGRGALIDEKALVKAIKEGKLKGFATDVFEEEP-VKEHEL--FRFKWETVLTPHYAGLG 289
N+GRG +++E L K I E ++ DV E EP +K H L + K ++TPH A
Sbjct: 230 NVGRGGIVNENDLAKIIDEKNIR-VGLDVLEIEPMMKNHPLLSIKNKENLIITPHVAWAS 288
Query: 290 KDVL 293
K+ L
Sbjct: 289 KEAL 292
>pir||C81362 phosphoglycerate dehydrogenase (EC 1.1.1.95) Cj0891c [imported] -
Campylobacter jejuni (strain NCTC 11168)
>gi|6968329|emb|CAB73149.1| (AL139076)
D-3-phosphoglycerate dehydrogenase [Campylobacter
jejuni]
Length = 527
Score = 136 bits (340), Expect = 3e-31
Identities = 98/319 (30%), Positives = 162/319 (50%), Gaps = 20/319 (6%)
Query: 1 MKPRIGVLFKMKSKPLEELKKYTDVVL---KPYPSEEELKEIIPELDGIIIAPVTRITKD 57
MK +I V + K ++ L+K D+ L +P ++EL +++ +++ I T + +
Sbjct: 1 MKKKIIVCDAILDKGVDILRKAEDIELIEAAKFP-KDELMQMLSDIEVAITRSSTDVDVN 59
Query: 58 ILERAERLKVISCQSAGYDHVDVEEATKRGIYVTKVSGLLSEAVAEFALGLLISLMRKIH 117
L A++LK + G D+VD+ E +KRG+ V V + A E + L++ R
Sbjct: 60 FLNHAKKLKALVRAGVGVDNVDIPECSKRGVIVMNVPTANTIAAVELTMAHLLTSARSFV 119
Query: 118 YADSFIR-EGKWESHTFVWREFKEVETLYGKEVGIVGMGAIGKAIARRLKPFGCEIY--- 173
A +F++ E KWE + E L K +G++G G IG +A R K FG +I
Sbjct: 120 NAHNFLKIERKWEREKWYGIE------LMNKTLGVIGFGNIGSRVAIRAKAFGMKILAYD 173
Query: 174 -YWSRHRKEDIEREVNAKYLDLDELLEEVDIVILALPLTKETYHIINEERVKKL-EGKYL 231
Y S + D++ E AK +LDE+LE+ D + + P TKET +I ++ + K+ +G L
Sbjct: 174 PYISASKITDLDME-QAK--NLDEILEKSDFITIHTPKTKETNGMIGKQEIAKMKDGIRL 230
Query: 232 VNIGRGALIDEKALVKAIKEGKLKGFATDVFEEEPVKEHELFRFKWETVLTPHYAGLGKD 291
+N RG L E+AL + +K GK+ DVF++EP H L F+ +T H +
Sbjct: 231 INCARGGLYTEEALYEGLKSGKIAWLGIDVFDKEPATNHPLLDFE-NISVTSHLGANTLE 289
Query: 292 VLEDMGFRAVENLLKVLRG 310
+++ A E L RG
Sbjct: 290 SQDNIAREACEQALSAARG 308
>emb|CAA12074.1| (AJ224690) C-terminal binding protein [Drosophila melanogaster]
Length = 386
Score = 136 bits (339), Expect = 4e-31
Identities = 94/316 (29%), Positives = 161/316 (50%), Gaps = 8/316 (2%)
Query: 19 LKKYTDVVLKPYPSEEELKE-IIPELDGIIIAPVTRITKDILERAERLKVISCQSAGYDH 77
LK V S E+ E ++ E G ++ +TK+ LE+ + L++I +G D+
Sbjct: 45 LKDVATVAFCDAQSTSEIHEKVLNEAVGALMWHTIILTKEDLEKFKALRIIVRIGSGTDN 104
Query: 78 VDVEEATKRGIYVTKVSGLLSEAVAEFALGLLISLMRKIHYADSFIREGKWESHTFVWRE 137
+DV+ A + GI V V G E VA+ + L+++L R+ ++ + +REGK + RE
Sbjct: 105 IDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRRTYWLANMVREGKKFTGPEQVRE 164
Query: 138 FKE-VETLYGKEVGIVGMGAIGKAIARRLKPFGCEIYYWSRHRKEDIEREVN-AKYLDLD 195
+ G +G+VG+G IG A+A R K FG + ++ + + I++ + + L
Sbjct: 165 AAHGCARIRGDTLGLVGLGRIGSAVALRAKAFGFNVIFYDPYLPDGIDKSLGLTRVYTLQ 224
Query: 196 ELLEEVDIVILALPLTKETYHIINEERVKKLE-GKYLVNIGRGALIDEKALVKAIKEGKL 254
+LL + D V L L + +H+INE +K++ G +LVN RG L+D++ L A+K+G++
Sbjct: 225 DLLFQSDCVSLHCTLNEHNHHLINEFTIKQMRPGAFLVNTARGGLVDDETLALALKQGRI 284
Query: 255 KGFATDVFEEEPVKEHE-LFRFKWETVLTPHYAGLGKDVLEDMGFRAVENLLKVLRGEIP 313
+ A DV E EP + + + TPH A ++ A + + + G IP
Sbjct: 285 RAAALDVHENEPYNVFQGALKDAPNLICTPHAAFFSDASATELREMAATEIRRAIVGNIP 344
Query: 314 EDL---VNKEVLKVRP 326
+ L VNKE P
Sbjct: 345 DVLRNCVNKEYFMRTP 360
>gb|AAF54891.1| (AE003698) CtBP gene product [alt 2] [Drosophila melanogaster]
>gi|7299710|gb|AAF54892.1| (AE003698) CtBP gene product
[alt 1] [Drosophila melanogaster]
Length = 386
Score = 136 bits (339), Expect = 4e-31
Identities = 94/316 (29%), Positives = 161/316 (50%), Gaps = 8/316 (2%)
Query: 19 LKKYTDVVLKPYPSEEELKE-IIPELDGIIIAPVTRITKDILERAERLKVISCQSAGYDH 77
LK V S E+ E ++ E G ++ +TK+ LE+ + L++I +G D+
Sbjct: 45 LKDVATVAFCDAQSTSEIHEKVLNEAVGALMWHTIILTKEDLEKFKALRIIVRIGSGTDN 104
Query: 78 VDVEEATKRGIYVTKVSGLLSEAVAEFALGLLISLMRKIHYADSFIREGKWESHTFVWRE 137
+DV+ A + GI V V G E VA+ + L+++L R+ ++ + +REGK + RE
Sbjct: 105 IDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRRTYWLANMVREGKKFTGPEQVRE 164
Query: 138 FKE-VETLYGKEVGIVGMGAIGKAIARRLKPFGCEIYYWSRHRKEDIEREVN-AKYLDLD 195
+ G +G+VG+G IG A+A R K FG + ++ + + I++ + + L
Sbjct: 165 AAHGCARIRGDTLGLVGLGRIGSAVALRAKAFGFNVIFYDPYLPDGIDKSLGLTRVYTLQ 224
Query: 196 ELLEEVDIVILALPLTKETYHIINEERVKKLE-GKYLVNIGRGALIDEKALVKAIKEGKL 254
+LL + D V L L + +H+INE +K++ G +LVN RG L+D++ L A+K+G++
Sbjct: 225 DLLFQSDCVSLHCTLNEHNHHLINEFTIKQMRPGAFLVNTARGGLVDDETLALALKQGRI 284
Query: 255 KGFATDVFEEEPVKEHE-LFRFKWETVLTPHYAGLGKDVLEDMGFRAVENLLKVLRGEIP 313
+ A DV E EP + + + TPH A ++ A + + + G IP
Sbjct: 285 RAAALDVHENEPYNVFQGALKDAPNLICTPHAAFFSDASATELREMAATEIRRAIVGNIP 344
Query: 314 EDL---VNKEVLKVRP 326
+ L VNKE P
Sbjct: 345 DVLRNCVNKEYFMRTP 360
>pir||S48189 hydroxypyruvate reductase (EC 1.1.1.81) - Hyphomicrobium
methylovorum >gi|1304133|dbj|BAA06662.1| (D31857)
hydroxypyruvate reductase [Hyphomicrobium methylovorum]
Length = 322
Score = 136 bits (338), Expect = 5e-31
Identities = 93/311 (29%), Positives = 158/311 (49%), Gaps = 13/311 (4%)
Query: 2 KPRIGVLFKMKSKPLEELKKYTDVVLK---PYPSEEELKEIIPELDGIIIAPVTRITKDI 58
K +I + + + + ++ DV+ P + +E+ E +D ++I + K++
Sbjct: 3 KKKILITWPLPEAAMARARESYDVIAHGDDPKITIDEMIETAKSVDALLITLNEKCRKEV 62
Query: 59 LERA-ERLKVISCQSAGYDHVDVEEATKRGIYVTKVSGLLSEAVAEFALGLLISLMRKIH 117
++R E +K IS S G+DH+D++ RGI V ++ A AE A+ LL+ R+
Sbjct: 63 IDRIPENIKCISTYSIGFDHIDLDACKARGIKVGNAPHGVTVATAEIAMLLLLGSARRAG 122
Query: 118 YADSFIREGKWESHTFVWREFKEV-ETLYGKEVGIVGMGAIGKAIARRLKPFGCEIYYWS 176
+ IR W W+ + V + L K +GI G G IG+A+A+R + F ++Y+
Sbjct: 123 EGEKMIRTRSWPG----WQPLQLVGQRLDNKTLGIYGFGKIGQALAQRARGFDMNVHYYD 178
Query: 177 RHR-KEDIEREVNAKYLD-LDELLEEVDIVILALPLTKETYHIINEERVKKL-EGKYLVN 233
+R K ++E + NA Y D LD LL+ + P T ET + N+E ++KL +G +VN
Sbjct: 179 IYRAKPEVEAKYNATYHDSLDSLLKVSQFFSINAPSTPETRYFFNKETIEKLPQGAIVVN 238
Query: 234 IGRGALIDEKALVKAIKEGKLKGFATDVFEEEPVKEHELFRFKWETVLTPHYAGLGKDVL 293
RG L+ + ++ A+K G+L DVF EP +E + T L PH +
Sbjct: 239 TARGDLVKDDDVIAALKSGRLAYAGFDVFAGEP-NINEGYYDLPNTFLFPHLGSAAIEAR 297
Query: 294 EDMGFRAVENL 304
MGF A++N+
Sbjct: 298 NQMGFEALDNI 308
>dbj|BAA25287.1| (AB011840) CtBP [Drosophila melanogaster]
Length = 383
Score = 136 bits (338), Expect = 5e-31
Identities = 94/315 (29%), Positives = 161/315 (50%), Gaps = 9/315 (2%)
Query: 19 LKKYTDVVLKPYPSEEELKE-IIPELDGIIIAPVTRITKDILERAERLKVISCQSAGYDH 77
LK V S E+ E ++ E G ++ +TK+ LE+ + L++I +G D+
Sbjct: 45 LKDVATVAFCDAQSTSEIHEKVLNEAVGALMWHTIILTKEDLEKFKALRIIVRIGSGTDN 104
Query: 78 VDVEEATKRGIYVTKVSGLLSEAVAEFALGLLISLMRKIHYADSFIREGKWESHTFVWRE 137
+DV+ A + GI V V G E VA+ + L+++L R+ ++ + +REGK + RE
Sbjct: 105 IDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRRTYWLANMVREGKKFTGPEQVRE 164
Query: 138 FKE-VETLYGKEVGIVGMGAIGKAIARRLKPFGCEIYYWSRHRKEDIEREVN-AKYLDLD 195
+ G +G+VG+G IG A+A R K FG + ++ + + I++ + + L
Sbjct: 165 AAHGCARIRGDTLGLVGLGRIGSAVALRAKAFGFNVIFYDPYLPDGIDKSLGLTRVYTLQ 224
Query: 196 ELLEEVDIVILALPLTKETYHIINEERVKKLE-GKYLVNIGRGALIDEKALVKAIKEGKL 254
+LL + D V L L + +H+INE +K++ G +LVN RG L+D++ L A+K+G++
Sbjct: 225 DLLFQSDCVSLHCTLNEHNHHLINEFTIKQMRPGAFLVNTARGGLVDDETLALALKQGRI 284
Query: 255 KGFATDVFEEEPVKEHELFRFKWETVLTPHYAGLGKDVLEDMGFRAVENLLKVLRGEIPE 314
+ A DV E EP + + + TPH A ++ A + + + G IP+
Sbjct: 285 RAAALDVHENEPY--NGALKDAPNLICTPHAAFFSDASATELREMAATEIRRAIVGNIPD 342
Query: 315 DL---VNKEVLKVRP 326
L VNKE P
Sbjct: 343 VLRNCVNKEYFMRTP 357
>pir||D71373 probable D-specific D-2-hydroxyacid dehydrogenase - syphilis
spirochete >gi|3322294|gb|AAC65033.1| (AE001189)
D-specific D-2-hydroxyacid dehydrogenase [Treponema
pallidum]
Length = 331
Score = 135 bits (336), Expect = 8e-31
Identities = 92/327 (28%), Positives = 168/327 (51%), Gaps = 29/327 (8%)
Query: 7 VLFKMKSKPLEELKKYTD----VVLKPY--PSEEELKEIIPELDGIIIAPVTRITKDILE 60
V+F ++ + ++K+ VV+ Y P + KE++ +G+++ + ++ +
Sbjct: 4 VVFNLREEEAPYVEKWKQSHPGVVVDTYEEPLTAKNKELLKGYEGLVVMQFLAMEDEVYD 63
Query: 61 R--AERLKVISCQSAGYDHVDVEEATKRGIYVTKVSGLLSEAVAEFALGLLISLMRKIHY 118
A +LKV+S ++AG+D + K GI +T V A+ E+AL + L R
Sbjct: 64 YMGACKLKVLSTRTAGFDMYNATLLKKHGIRLTNVPSYSPNAIGEYALAAALQLTRHARE 123
Query: 119 ADSFIREGKWESHTFVWREFKEVETLYGKEVGIVGMGAIGKAIARRLKPFGCEIYYWSRH 178
++F+R+ F W++ + L VGI+G G IG+A AR K G ++ + +
Sbjct: 124 IETFVRK-----RDFRWQKPILSKELRCSRVGILGTGRIGQAAARLFKGVGAQVVGFDPY 178
Query: 179 RKEDIEREVNAKYLDLDELLEEVDIVILALPLTKETYHIINEERVKKL-EGKYLVNIGRG 237
+ + + Y+ +DELL D++ L +P TK+++H+IN + + ++ +G YLVN RG
Sbjct: 179 PNDAAKEWLT--YVSMDELLSTSDVISLHMPATKDSHHLINAKTIAQMKDGVYLVNTARG 236
Query: 238 ALIDEKALVKAIKEGKLKGFATDVFEEE-----------PVKEHELFRF--KWETVLTPH 284
A+ID +AL+ ++ +GK+ G A D +E E P+ + R + TPH
Sbjct: 237 AVIDSQALLDSLDKGKIAGAALDAYEFEGPYIPKDNGNNPITDTVYARLVAHERIIYTPH 296
Query: 285 YAGLGKDVLEDMGFRAVENLLKVLRGE 311
A + +E+M F +++ VLRGE
Sbjct: 297 IAFYTETAIENMVFNSLDACTTVLRGE 323
>gb|AAG34690.1|AF310956_5 (AF310956) D-2-hydroxyacid dehydrogenase VanHB2 [Enterococcus
faecium]
Length = 323
Score = 135 bits (336), Expect = 8e-31
Identities = 93/265 (35%), Positives = 144/265 (54%), Gaps = 39/265 (14%)
Query: 65 LKVISCQSAGYDHVDVEEATKRGIYVTKVSGLLSEAVAEFALGLLISLMRKIHYADSFIR 124
+K IS +S G DH+D A + GI V V+ ++VA++AL L++ IR
Sbjct: 73 VKYISTRSIGCDHIDTTAAERMGISVGTVA-YSPDSVADYALMLMLMA----------IR 121
Query: 125 EGKWESHTFVWREFKEVETLYGKE-----VGIVGMGAIGKAIARRLKPFGCEIYYWSRHR 179
K H ++F+ ++ + GKE VG++G G IG+A+ +RL+ FGC + + R
Sbjct: 122 GAKPTMHAVAQQDFR-LDRIRGKELGDMTVGVIGTGHIGQAVVKRLRGFGCHVLAYDNSR 180
Query: 180 KEDIEREVNAKYLDLDELLEEVDIVILALPLTKETYHIINEERVKKL-EGKYLVNIGRGA 238
K D A Y+ LDELL+ DIV L +PL +T H+I ++++ ++ +G +L+N GRGA
Sbjct: 181 KMD------ADYVQLDELLKNSDIVTLHVPLCADTRHLIGQKQIGEMKQGAFLINTGRGA 234
Query: 239 LIDEKALVKAIKEGKLKGFATDVFEEE----------PVKEH----ELFRFKWETVLTPH 284
L+D ALV+A++ GKL G A DV E E V +H +L R ++TPH
Sbjct: 235 LVDTGALVEALESGKLGGAALDVLEGEDQFVYTDCSQKVLDHPFLSQLLRMP-NVIITPH 293
Query: 285 YAGLGKDVLEDMGFRAVENLLKVLR 309
A + VL+D + + N L R
Sbjct: 294 TAYYTERVLQDTTEKTIRNCLNFER 318
>pir||S75499 D-isomer specific 2-hydroxyacid dehydrogenase family -
Synechocystis sp. (strain PCC 6803)
>gi|1653144|dbj|BAA18060.1| (D90911) D-isomer specific
2-hydroxyacid dehydrogenase family [Synechocystis sp.]
Length = 318
Score = 134 bits (335), Expect = 1e-30
Identities = 83/282 (29%), Positives = 150/282 (52%), Gaps = 13/282 (4%)
Query: 32 SEEELKEIIPELDGIIIA--PVTRITKDILERAERLKVISCQSAGYDHVDVEEATKRGIY 89
SE EL E I + DG+I P T I ++ +LK ++ G D +D+ A + GI
Sbjct: 40 SEAELCEQIADFDGVIAGDDPFTARVLTIGKQG-KLKALAKWGIGVDAIDLAAAKQLGIL 98
Query: 90 VTKVSGLLSEAVAEFALGLLISLMRKIHYADSFIREGKWESHTFVWREFKEVETLYGKEV 149
+ + + VA+ A+G LI L R++H D +R+G+W +L GK
Sbjct: 99 TSNTPNVFGDEVADVAIGYLILLARELHCIDQAVRQGEWLK--------IRGHSLRGKTA 150
Query: 150 GIVGMGAIGKAIARRLKPFGCEIYYWSRHR-KEDIEREVNAKYLDLDELLEEVDIVILAL 208
GI+G+G+IG+AIA RL+ G ++ + H D + + L ++L++ D + LA
Sbjct: 151 GIIGVGSIGQAIAVRLQSMGLKLLGYDPHPISADFCEQTGLHPVPLQDVLQQADCLFLAC 210
Query: 209 PLTKETYHIINEERVKKLE-GKYLVNIGRGALIDEKALVKAIKEGKLKGFATDVFEEEPV 267
LT + +H++N + +++ G +L+N+ RG L+D+ AL++ ++ GK+ A DVFE+EP+
Sbjct: 211 NLTPDNFHLLNADTFDQMKPGVWLINVARGGLVDQAALIETLQTGKVAKAALDVFEQEPL 270
Query: 268 KEHELFRFKWETVLTPHYAGLGKDVLEDMGFRAVENLLKVLR 309
+ +L H ++ + + A++NL++ L+
Sbjct: 271 AADSPLTQLPQVILGSHNGSNTREAVLKVNQLAIDNLVRDLQ 312
>sp|Q59516|DHGY_METEX GLYCERATE DEHYDROGENASE (NADH-DEPENDENT HYDROXYPYRUVATE REDUCTASE)
(HPR) (GDH) (HYDROXYPYRUVATE DEHYDROGENASE) (GLYOXYLATE
REDUCTASE) (HPR-A)
Length = 314
Score = 134 bits (335), Expect = 1e-30
Identities = 90/297 (30%), Positives = 163/297 (54%), Gaps = 18/297 (6%)
Query: 28 KPYPSEEELKEIIPELDGIIIAPVTRITK--DILERAERLKVISCQSAGYDHVDVEEATK 85
K Y S +EI+ L G IA + ++ D L++ LK+I+ + G D VD A
Sbjct: 27 KEYESTWTPEEIVERLQGAEIAMINKVPMRADTLKQLPDLKLIAVAATGTDVVDKAAAKA 86
Query: 86 RGIYVTKVSGLLSEAVAEFALGLLISLMRKI-HYADSFIREGKW-ESHTFVWREFKEVET 143
+GI V + V E +GL+ +L R I YA+S +R G W +S F + ++ +
Sbjct: 87 QGITVVNIRNYAFNTVPEHVVGLMFALRRAIVPYANS-VRRGDWNKSKQFCYFDYP-IYD 144
Query: 144 LYGKEVGIVGMGAIGKAIARRLKPFGCEIYYWSRHRKEDIEREVNAKYLDLDELLEEVDI 203
+ G +GI+G GA+GK+IA+R + G ++ + ++ + +DL+ +L + D+
Sbjct: 145 IAGSTLGIIGYGALGKSIAKRAEALGMKVLAFDVFPQDGL--------VDLETILTQSDV 196
Query: 204 VILALPLTKETYHIINEERVKKLE-GKYLVNIGRGALIDEKALVKAIKEGKLKGFATDVF 262
+ L +PLT +T ++I E++KK++ L+N RG L+DE AL++A+K+G + G DV
Sbjct: 197 ITLHVPLTPDTKNMIGAEQLKKMKRSAILINTARGGLVDEAALLQALKDGTIGGAGFDVV 256
Query: 263 EEEPVKEHELF--RFKWETVLTPHYAGLGKDVLEDMGFRAVENLLKVLRGEIPEDLV 317
+EP K+ + ++TPH A K+ ++ + + V+N+ + G+ P+++V
Sbjct: 257 AQEPPKDGNILCDADLPNLIVTPHVAWASKEAMQILADQLVDNVEAFVAGK-PQNVV 312
>gb|AAG10470.1|AF279106_32 (AF279106) predicted NAD-dependent formate dehydrogenase
[uncultured proteobacterium EBAC31A08]
Length = 398
Score = 134 bits (333), Expect = 2e-30
Identities = 74/237 (31%), Positives = 134/237 (56%), Gaps = 7/237 (2%)
Query: 54 ITKDILERAERLKVISCQSAGYDHVDVEEATKRGIYVTKVSGLLSEAVAEFALGLLISLM 113
+T+D ++ A LK+ G DHVD++ A + V +V+ S +VAE + +++S++
Sbjct: 103 LTRDKMKTAPNLKMAITAGIGSDHVDLQAAMDNSVDVVEVTYCNSRSVAEHIVMMILSMV 162
Query: 114 RKIHYADSFIREGKWESHTFVWREFKEVETLYGKEVGIVGMGAIGKAIARRLKPFGCEIY 173
R H ++EG W V R + +VE G VG V G IG + R++KPF ++
Sbjct: 163 RDYHTQHRIVKEGGWNIADAVQRSY-DVE---GMHVGTVAAGRIGIDMLRKMKPFDVHLH 218
Query: 174 YWSRHR-KEDIEREVNAKYLD-LDELLEEVDIVILALPLTKETYHIINEERVKKLE-GKY 230
Y+ H+ ++IE E+N Y D ++ L+ D+V ++ PL +T H+ ++E + K++ G Y
Sbjct: 219 YFDIHKLSDEIEAELNLTYHDSVESLVAVCDVVNISCPLHPKTEHLFDDEMISKMKRGAY 278
Query: 231 LVNIGRGALIDEKALVKAIKEGKLKGFATDVFEEEPVKEHELFRFKWETVLTPHYAG 287
++N RG + D+ A+ + ++ G+L G+A DV+ +P ++R +TPH +G
Sbjct: 279 IINTARGKICDKDAIARGLESGQLSGYAGDVWFPQPAPNDHVWRTMPNHGMTPHTSG 335
>gb|AAD19834.1| (AF060799) D-lactate dehydrogenase [Amycolatopsis orientalis]
Length = 348
Score = 133 bits (332), Expect = 2e-30
Identities = 96/283 (33%), Positives = 151/283 (52%), Gaps = 29/283 (10%)
Query: 46 IIIAPVTRITKDILERAERLKV--ISCQSAGYDHVDVEEATKRGIYVTKVSGLLSEAVAE 103
I I T++T IL V IS +S G++H+DVE A GI V V+ ++VA+
Sbjct: 75 ISIGHKTKVTNSILLALAEAGVEYISTRSIGFNHIDVEYAASVGITVGNVA-YSPDSVAD 133
Query: 104 FALGLLISLMRKIHYADSFIREGKWESHTFVWREFKEVETLYGKEVGIVGMGAIGKAIAR 163
F L L++ +R A S IR + E H + E + E L VG+VG G IG A+
Sbjct: 134 FTLMLMLMAVRD---AKSIIR--RTEVHDYRLNEVRGKE-LRDLTVGVVGTGRIGVAVLD 187
Query: 164 RLKPFGCEIYYWSRHRKEDIEREVNAKYLDLDELLEEVDIVILALPLTKETYHIINEERV 223
RL+ FGC + + D +A Y+ LDELL++ DIV L +PL +TYH+++ + +
Sbjct: 188 RLRGFGCRVLAY------DTLLTASADYVPLDELLQQSDIVTLHVPLNNDTYHLLDRKNI 241
Query: 224 KKL-EGKYLVNIGRGALIDEKALVKAIKEGKLKGFATDVFEEE-----------PVKEHE 271
+++ +G Y++N GRG LI+ +AL+ A+++GKL G A DV E E P++
Sbjct: 242 ERMKDGAYIINTGRGPLIETEALISALEDGKLGGAALDVVEGEEGIFYADCRNKPLESET 301
Query: 272 LFRFKW--ETVLTPHYAGLGKDVLEDMGFRAVENLLKVLRGEI 312
L R + +++PH A L D ++ N L+ + E+
Sbjct: 302 LLRLEKLPNVLISPHTAYYTDHALSDTVENSIINCLQFRKREV 344
>dbj|BAA36181.1| (D88272) formate dehydrogenase [Hordeum vulgare]
Length = 377
Score = 133 bits (331), Expect = 3e-30
Identities = 78/258 (30%), Positives = 143/258 (55%), Gaps = 9/258 (3%)
Query: 35 ELKEIIPELDGIIIAPV--TRITKDILERAERLKVISCQSAGYDHVDVEEATKRGIYVTK 92
EL++ I ++ +I P +T + +++A+ +++ G DH+D+ A G+ V +
Sbjct: 81 ELEKHIEDMHVLITTPFHPAYVTAEKIKKAKTPELLLTAGIGSDHIDLPAAAAAGLTVAR 140
Query: 93 VSGLLSEAVAEFALGLLISLMRKIHYADSFIREGKWESHTFVWREFKEVETLYGKEVGIV 152
V+G + +VAE L ++ L+R + +G+W R + L GK VG V
Sbjct: 141 VTGSNTVSVAEDELMRILILLRNFLPGYQQVVKGEWNVAGIAHRAYD----LEGKTVGTV 196
Query: 153 GMGAIGKAIARRLKPFGCEIYYWSRHR-KEDIEREVNAKYL-DLDELLEEVDIVILALPL 210
G G G+ + +RLKPF C + Y R + ++E+E+ AK+ DLD +L + D+V++ PL
Sbjct: 197 GAGRYGRLLLQRLKPFNCNLLYHDRLQINPELEKEIGAKFEEDLDAMLPKCDVVVINTPL 256
Query: 211 TKETYHIINEERVKKLE-GKYLVNIGRGALIDEKALVKAIKEGKLKGFATDVFEEEPVKE 269
T++T + N+E++ K++ G +VN RGA++D +A+ A G + G+ DV+ +P +
Sbjct: 257 TEKTRGMFNKEKIAKMKKGVIIVNNARGAIMDTQAVADACSSGHIAGYGGDVWFPQPAPK 316
Query: 270 HELFRFKWETVLTPHYAG 287
+R+ +TPH +G
Sbjct: 317 DHPWRYMPNHAMTPHISG 334
>gb|AAF16561.1|AC012563_14 (AC012563) hydroxypyruvate reductase (HPR); 50972-48670
[Arabidopsis thaliana]
Length = 386
Score = 132 bits (330), Expect = 4e-30
Identities = 92/266 (34%), Positives = 135/266 (50%), Gaps = 28/266 (10%)
Query: 66 KVISCQSAGYDHVDVEEATKRGIYVTKVSGLLSEAVAEFALGLLISLMRKIHYADSFIRE 125
K S + GY++VDVE A K GI V G+L+E AE A L ++ R+I AD F+R
Sbjct: 88 KAFSNMAVGYNNVDVEAANKYGIAVGNTPGVLTETTAELAASLSLAAARRIVEADEFMRG 147
Query: 126 G---KWESHTFVWREFKEVETLYGKEVGIVGMGAIGKAIARRL-KPFGCEIYYWSRHRKE 181
G W H FV K G+ VG++G G IG A AR + + F + Y+ ++
Sbjct: 148 GLYEGWLPHLFVGNLLK------GQTVGVIGAGRIGSAYARMMVEGFKMNLIYFDLYQST 201
Query: 182 DIEREVNA----------------KYLDLDELLEEVDIVILALPLTKETYHIINEERVKK 225
+E+ V A + ++E+L E D++ L L K TYH++N+ER+
Sbjct: 202 RLEKFVTAYGQFLKANGEQPVTWKRASSMEEVLREADLISLHPVLDKTTYHLVNKERLAM 261
Query: 226 LEGK-YLVNIGRGALIDEKALVKAIKEGKLKGFATDVFEEEPVKEHELFRFKWETVLTPH 284
++ + LVN RG +IDE ALV+ +KE + DVFEEEP + L K ++ PH
Sbjct: 262 MKKEAILVNCSRGPVIDEAALVEHLKENPMFRVGLDVFEEEPFMKPGLADTK-NAIVVPH 320
Query: 285 YAGLGKDVLEDMGFRAVENLLKVLRG 310
A K E M A N+L ++G
Sbjct: 321 IASASKWTREGMATLAALNVLGRVKG 346
>sp|P52643|LDHD_ECOLI D-LACTATE DEHYDROGENASE (D-LDH) >gi|7431359|pir||G64888 D-lactate
dehydrogenase (EC 1.1.1.28) - Escherichia coli
>gi|1049265|gb|AAB51772.1| (U36928) D-lactate
dehydrogenase [Escherichia coli]
>gi|1742259|dbj|BAA14990.1| (D90776) D-lactate
dehydrogenase (EC 1.1.1.28) (D-LDH). [Escherichia coli]
>gi|1787645|gb|AAC74462.1| (AE000235) fermentative
D-lactate dehydrogenase, NAD-dependent [Escherichia coli
K12]
Length = 329
Score = 132 bits (328), Expect = 7e-30
Identities = 89/280 (31%), Positives = 149/280 (52%), Gaps = 24/280 (8%)
Query: 55 TKDILERAER--LKVISCQSAGYDHVDVEEATKRGIYVTKVSGLLSEAVAEFALGLLISL 112
++ +LE ++ +K I+ + AG+++VD++ A + G+ V +V EAVAE A+G++++L
Sbjct: 57 SRPVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTL 116
Query: 113 MRKIHYADSFIREGKWESHTFVWREFKEVETLYGKEVGIVGMGAIGKAIARRLKPFGCEI 172
R+IH A R+ + E T+YGK G++G G IG A+ R LK FG +
Sbjct: 117 NRRIHRAYQRTRDANFS------LEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRL 170
Query: 173 YYWSRHRKEDIEREVNAKYLDLDELLEEVDIVILALPLTKETYHIINEERVKKLE-GKYL 231
+ + E+ +Y+DL L E D++ L PLT E YH++NE ++++ G +
Sbjct: 171 LAFDPY-PSAAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMI 229
Query: 232 VNIGRGALIDEKALVKAIKEGKLKGFATDVFEEE----------PVKEHELFR---FKWE 278
VN RGALID +A ++A+K K+ DV+E E V + ++FR
Sbjct: 230 VNTSRGALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHN 289
Query: 279 TVLTPHYAGLGKDVLEDMGFRAVENLLKVLRGE-IPEDLV 317
+ T H A L + L + ++NL + +GE P +LV
Sbjct: 290 VLFTGHQAFLTAEALTSISQTTLQNLSNLEKGETCPNELV 329
>emb|CAA73696.1| (Y13245) NAD-dependent formate dehydrogenase [Moraxella sp.]
Length = 402
Score = 132 bits (328), Expect = 7e-30
Identities = 86/260 (33%), Positives = 138/260 (53%), Gaps = 9/260 (3%)
Query: 33 EEELKEIIPELDGIIIAPV--TRITKDILERAERLKVISCQSAGYDHVDVEEATKRGIYV 90
+ EL++ + + + II P +T + + +A +LK+ G DHVD++ A I V
Sbjct: 81 DSELEKHLHDAEVIISQPFWPAYLTAERIAKAPKLKLALTAGIGSDHVDLQAAIDNNITV 140
Query: 91 TKVSGLLSEAVAEFALGLLISLMRKIHYADSFIREGKWESHTFVWREFKEVETLYGKEVG 150
+V+ S +VAE + +++ L+R + + R G W V R + +VE G VG
Sbjct: 141 AEVTYCNSNSVAEHVVMMVLGLVRNYIPSHDWARNGGWNIADCVARSY-DVE---GMHVG 196
Query: 151 IVGMGAIGKAIARRLKPFGCEIYYWSRHR-KEDIEREVNAKY-LDLDELLEEVDIVILAL 208
V G IG + R L PF ++Y RHR E +E+E+N + +++ D+V L
Sbjct: 197 TVAAGRIGLRVLRLLAPFDMHLHYTDRHRLPEAVEKELNLTWHATREDMYGACDVVTLNC 256
Query: 209 PLTKETYHIINEERVKKLE-GKYLVNIGRGALIDEKALVKAIKEGKLKGFATDVFEEEPV 267
PL ET H+IN+E +K + G YLVN RG L D A+V+A++ G+L G+A DV+ +P
Sbjct: 257 PLHPETEHMINDETLKLFKRGAYLVNTARGKLCDRDAIVRALESGRLAGYAGDVWFPQPA 316
Query: 268 KEHELFRFKWETVLTPHYAG 287
+R +TPH +G
Sbjct: 317 PNDHPWRTMPHNGMTPHISG 336
>sp|P30799|DDH_ZYMMO 2-HYDROXYACID DEHYDROGENASE HOMOLOG >gi|538722|pir||D40649
D-2-hydroxy-acid dehydrogenase (EC 1.1.99.6) - Zymomonas
mobilis >gi|155574|gb|AAA71934.1| (L09650) Shows
homology to D-isomer specific
2-hydroxyaciddehydrogenases, including Lactobacillus
plantarum lactatedehydrogenase [Zymomonas mobilis]
Length = 331
Score = 131 bits (327), Expect = 9e-30
Identities = 86/270 (31%), Positives = 144/270 (52%), Gaps = 24/270 (8%)
Query: 65 LKVISCQSAGYDHVDVEEATKRGIYVTKVSGLLSEAVAEFALGLLISLMRKIHYADSFIR 124
+K+++ + AGY++VD++ A K I V +V +VAE+A+G+L++L R+I +R
Sbjct: 69 IKLVALRCAGYNNVDLDAAKKLNIKVVRVPAYSPYSVAEYAVGMLLTLNRQISRGLKRVR 128
Query: 125 EGKWESHTFVWREFKEVETLYGKEVGIVGMGAIGKAIARRLKP-FGCEIYYWSRHRKEDI 183
E + + + ++ K VGI+G+G IG A + FG + + H ++
Sbjct: 129 ENNFSLEGLIGLD------VHDKTVGIIGVGHIGSVFAHIMTHGFGANVIAYKPHPDPEL 182
Query: 184 EREVNAKYLDLDELLEEVDIVILALPLTKETYHIINEERVKKLE-GKYLVNIGRGALIDE 242
+V ++ LDE++E DI+ L PLT E +H+IN E + + + G YLVN RG L+D
Sbjct: 183 AEKVGFRFTSLDEVIETSDIISLHCPLTPENHHMINGETLARAKKGFYLVNTSRGGLVDT 242
Query: 243 KALVKAIKEGKLKGFATDVFEEEP---VKEH-----------ELFRFKWETVLTPHYAGL 288
KA++K++K L G+A DV+EEE + H L F V T H A L
Sbjct: 243 KAVIKSLKAKHLGGYAADVYEEEGPLFFENHADDIIEDDILERLIAFP-NVVFTGHQAFL 301
Query: 289 GKDVLEDMGFRAVENLLKVLRG-EIPEDLV 317
K+ L ++ ++++ G E+P+ LV
Sbjct: 302 TKEALSNIAHSILQDISDAEAGKEMPDALV 331
>pir||A75414 D-3-phosphoglycerate dehydrogenase - Deinococcus radiodurans
(strain R1) >gi|6459038|gb|AAF10861.1|AE001976_4
(AE001976) D-3-phosphoglycerate dehydrogenase
[Deinococcus radiodurans]
Length = 544
Score = 131 bits (327), Expect = 9e-30
Identities = 91/300 (30%), Positives = 152/300 (50%), Gaps = 10/300 (3%)
Query: 34 EELKEIIPELDGIIIAPVTRITKDILERA-ERLKVISCQSAGYDHVDVEEATKRGIYVTK 92
EE +P+ D +I T++ +++L+ A RLKVI G D++D+E A++RG+ V
Sbjct: 49 EETLRRLPDYDALITRSRTKVDRELLDAAGPRLKVIGRGGVGVDNIDLEYASRRGLLVLN 108
Query: 93 VSGLLSEAVAEFALGLLISLMRKIHYADSFIREGKWESHTFVWREFKEVETLYGKEVGIV 152
+ + AE A+ L++ R + +D R G+W+ R+F +E L K +GIV
Sbjct: 109 APESNNVSAAELAVMHLMAAARGLTRSDRKTRAGEWD------RKFLGLE-LTDKTLGIV 161
Query: 153 GMGAIGKAIARRLKPFGCEIYYWSRHRKED-IEREVNAKYLDLDELLEEVDIVILALPLT 211
G+G IG +A R + + + + E+ ER + LDELL +VD + + PLT
Sbjct: 162 GLGRIGSIVADRAQGLHMNVVAYDPYVPENKFERLGVQRAASLDELLGQVDALTVHTPLT 221
Query: 212 KETYHIINEERVKKLE-GKYLVNIGRGALIDEKALVKAIKEGKLKGFATDVFEEEPVKEH 270
ET +I E + L+ +VN RG +I+E+ALV A+ G L DVF +EP
Sbjct: 222 DETRGMIGERELALLKRDAIVVNAARGGIIEEQALVNALHAGHLFAAGVDVFVDEPPTAE 281
Query: 271 ELFRFKWETVLTPHYAGLGKDVLEDMGFRAVENLLKVLRGEIPEDLVNKEVLKVRPIDEV 330
+F +T H ++ E +G V +L L G++ + VN L + ++++
Sbjct: 282 HIFLGAPNLGITAHLGANTREAQERVGAEIVSRVLDALHGDVSKGAVNAPALDAKTMEQL 341
>pir||T50134 2-hydroxyacid dehydrogenase [imported] - fission yeast
(Schizosaccharomyces pombe) >gi|7024424|emb|CAB75871.1|
(AL157811) 2-hydroxyacid dehydrogenase
[Schizosaccharomyces pombe]
Length = 332
Score = 131 bits (327), Expect = 9e-30
Identities = 83/245 (33%), Positives = 138/245 (55%), Gaps = 24/245 (9%)
Query: 66 KVISCQSAGYDHVDVEEATKRGIYVTKVSGLLSEAVAEFALGLLISLMRKIHYADSFIRE 125
K+I+ + AG+++VD++ A GI V +V AVAE+ +GLL+SL RKIH A +RE
Sbjct: 70 KLIALRCAGFNNVDLKAAADNGITVVRVPAYSPYAVAEYTIGLLLSLNRKIHRAYVRVRE 129
Query: 126 GKWESHTFVWREFKEVETLYGKEVGIVGMGAIGKAIARRLK-PFGCEIYYWSRHRKEDIE 184
+ + + + L+GK +G++G G IG +A+ LK FGCE+ +++E
Sbjct: 130 DDFNLNGLLGHD------LHGKTIGLLGTGRIGGLVAKCLKLGFGCEVLAHDIKPNKELE 183
Query: 185 REVNAKYLDLDELLEEVDIVILALPLTKETYHIINEERVKKL-EGKYLVNIGRGALIDEK 243
+ ++++ E+L + D + L PLT +T H+++E+ + + +G ++N RG L+D K
Sbjct: 184 K-FGIQFVEQQEVLAKADFLCLHCPLTPDTEHLVDEKLLASMKKGVKIINTSRGGLVDTK 242
Query: 244 ALVKAIKEGKLKGFATDVFEEEPVKEHELFRFKWETVLTPHYAGLGKDVLEDMGFRAVEN 303
ALVKAI+ G++ G A DV+E E LF Y L +V++D F+ + N
Sbjct: 243 ALVKAIESGQVGGCAMDVYE----GERRLF-----------YRDLSNEVIKDTTFQQLAN 287
Query: 304 LLKVL 308
VL
Sbjct: 288 FPNVL 292
>pdb|2NAD|A Chain A, Nad-Dependent Formate Dehydrogenase (E.C.1.2.1.2) (Holo
Form) Complexed With Nad And Azide >gi|999848|pdb|2NAD|B
Chain B, Nad-Dependent Formate Dehydrogenase
(E.C.1.2.1.2) (Holo Form) Complexed With Nad And Azide
>gi|999845|pdb|2NAC|A Chain A, Nad-Dependent Formate
Dehydrogenase (E.C.1.2.1.2) (Apo Form)
>gi|999846|pdb|2NAC|B Chain B, Nad-Dependent Formate
Dehydrogenase (E.C.1.2.1.2) (Apo Form)
Length = 393
Score = 131 bits (326), Expect = 1e-29
Identities = 79/237 (33%), Positives = 132/237 (55%), Gaps = 7/237 (2%)
Query: 54 ITKDILERAERLKVISCQSAGYDHVDVEEATKRGIYVTKVSGLLSEAVAEFALGLLISLM 113
+T + + +A+ LK+ G DHVD++ A R + V +V+ S +VAE + +++SL+
Sbjct: 103 LTPERIAKAKNLKLALTAGIGSDHVDLQSAIDRNVTVAEVTYCNSISVAEHVVMMILSLV 162
Query: 114 RKIHYADSFIREGKWESHTFVWREFKEVETLYGKEVGIVGMGAIGKAIARRLKPFGCEIY 173
R + + R+G W V + ++E ++ VG V G IG A+ RRL PF ++
Sbjct: 163 RNYLPSHEWARKGGWNIADCVSHAY-DLEAMH---VGTVAAGRIGLAVLRRLAPFDVHLH 218
Query: 174 YWSRHR-KEDIEREVNAKY-LDLDELLEEVDIVILALPLTKETYHIINEERVKKLE-GKY 230
Y RHR E +E+E+N + +++ D+V L PL ET H+IN+E +K + G Y
Sbjct: 219 YTDRHRLPESVEKELNLTWHATREDMYPVCDVVTLNCPLHPETEHMINDETLKLFKRGAY 278
Query: 231 LVNIGRGALIDEKALVKAIKEGKLKGFATDVFEEEPVKEHELFRFKWETVLTPHYAG 287
+VN RG L D A+ +A++ G+L G+A DV+ +P + +R +TPH +G
Sbjct: 279 IVNTARGKLCDRDAVARALESGRLAGYAGDVWFPQPAPKDHPWRTMPYNGMTPHISG 335
>gb|AAB36206.1| NAD(+)-dependent formate dehydrogenase, McFDH {EC 1.2.1.2}
[Mycobacterium vaccae, N10, Peptide, 400 aa]
Length = 400
Score = 131 bits (326), Expect = 1e-29
Identities = 79/237 (33%), Positives = 132/237 (55%), Gaps = 7/237 (2%)
Query: 54 ITKDILERAERLKVISCQSAGYDHVDVEEATKRGIYVTKVSGLLSEAVAEFALGLLISLM 113
+T + + +A+ LK+ G DHVD++ A R + V +V+ S +VAE + +++SL+
Sbjct: 103 LTPERIAKAKNLKLALTAGIGSDHVDLQSAIDRNVTVAEVTYCNSISVAEHVVMMILSLV 162
Query: 114 RKIHYADSFIREGKWESHTFVWREFKEVETLYGKEVGIVGMGAIGKAIARRLKPFGCEIY 173
R + + R+G W V + ++E ++ VG V G IG A+ RRL PF ++
Sbjct: 163 RNYLPSHEWARKGGWNIADCVSHAY-DLEAMH---VGTVAAGRIGLAVLRRLAPFDVHLH 218
Query: 174 YWSRHR-KEDIEREVNAKY-LDLDELLEEVDIVILALPLTKETYHIINEERVKKLE-GKY 230
Y RHR E +E+E+N + +++ D+V L PL ET H+IN+E +K + G Y
Sbjct: 219 YTDRHRLPESVEKELNLTWHATREDMYPVCDVVTLNCPLHPETEHMINDETLKLFKRGAY 278
Query: 231 LVNIGRGALIDEKALVKAIKEGKLKGFATDVFEEEPVKEHELFRFKWETVLTPHYAG 287
+VN RG L D A+ +A++ G+L G+A DV+ +P + +R +TPH +G
Sbjct: 279 IVNTARGKLCDRDAVARALESGRLAGYAGDVWFPQPAPKDHPWRTMPYNGMTPHISG 335
>sp|P33160|FDH_PSESR FORMATE DEHYDROGENASE (NAD-DEPENDENT FORMATE DEHYDROGENASE) (FDH)
Length = 401
Score = 131 bits (326), Expect = 1e-29
Identities = 79/237 (33%), Positives = 132/237 (55%), Gaps = 7/237 (2%)
Query: 54 ITKDILERAERLKVISCQSAGYDHVDVEEATKRGIYVTKVSGLLSEAVAEFALGLLISLM 113
+T + + +A+ LK+ G DHVD++ A R + V +V+ S +VAE + +++SL+
Sbjct: 104 LTPERIAKAKNLKLALTAGIGSDHVDLQSAIDRNVTVAEVTYCNSISVAEHVVMMILSLV 163
Query: 114 RKIHYADSFIREGKWESHTFVWREFKEVETLYGKEVGIVGMGAIGKAIARRLKPFGCEIY 173
R + + R+G W V + ++E ++ VG V G IG A+ RRL PF ++
Sbjct: 164 RNYLPSHEWARKGGWNIADCVSHAY-DLEAMH---VGTVAAGRIGLAVLRRLAPFDVHLH 219
Query: 174 YWSRHR-KEDIEREVNAKY-LDLDELLEEVDIVILALPLTKETYHIINEERVKKLE-GKY 230
Y RHR E +E+E+N + +++ D+V L PL ET H+IN+E +K + G Y
Sbjct: 220 YTDRHRLPESVEKELNLTWHATREDMYPVCDVVTLNCPLHPETEHMINDETLKLFKRGAY 279
Query: 231 LVNIGRGALIDEKALVKAIKEGKLKGFATDVFEEEPVKEHELFRFKWETVLTPHYAG 287
+VN RG L D A+ +A++ G+L G+A DV+ +P + +R +TPH +G
Sbjct: 280 IVNTARGKLCDRDAVARALESGRLAGYAGDVWFPQPAPKDHPWRTMPYNGMTPHISG 336
>gb|AAF72362.1|AF192329_23 (AF192329) VanHB [Enterococcus faecalis]
Length = 323
Score = 131 bits (326), Expect = 1e-29
Identities = 91/265 (34%), Positives = 143/265 (53%), Gaps = 39/265 (14%)
Query: 65 LKVISCQSAGYDHVDVEEATKRGIYVTKVSGLLSEAVAEFALGLLISLMRKIHYADSFIR 124
+K IS +S G DH+D A + GI V V+ ++VA++AL L++ IR
Sbjct: 73 VKYISTRSIGCDHIDTTAAERMGISVGTVA-YSPDSVADYALMLMLMA----------IR 121
Query: 125 EGKWESHTFVWREFKEVETLYGKEVG-----IVGMGAIGKAIARRLKPFGCEIYYWSRHR 179
K H ++F+ ++ + GKE+G ++G G IG+A+ +RL+ FGC + + R
Sbjct: 122 GAKPTMHAVAQQDFR-LDRIRGKELGDMTVRVIGTGHIGQAVVKRLRGFGCHVLAYDNSR 180
Query: 180 KEDIEREVNAKYLDLDELLEEVDIVILALPLTKETYHIINEERVKKL-EGKYLVNIGRGA 238
K D A Y+ LDELL+ IV L +PL +T H+I ++++ ++ +G +L+N GRGA
Sbjct: 181 KMD------ADYVQLDELLKNSGIVTLHVPLCADTRHLIGQKQIGEMKQGAFLINTGRGA 234
Query: 239 LIDEKALVKAIKEGKLKGFATDVFEEE----------PVKEH----ELFRFKWETVLTPH 284
L+D ALV+A++ GKL G A DV E E V +H +L R ++TPH
Sbjct: 235 LVDTGALVEALESGKLGGAALDVLEGEDQFVYTDCSQKVLDHPFLSQLLRMP-NVIITPH 293
Query: 285 YAGLGKDVLEDMGFRAVENLLKVLR 309
A + VL+D + + N L R
Sbjct: 294 TAYYTERVLQDTTEKTIRNCLNFER 318
>sp|Q05709|VANH_ENTFC D-SPECIFIC ALPHA-KETO ACID DEHYDROGENASE (VANCOMYCIN RESISTANCE
PROTEIN VANH) >gi|79974|pir||JQ1191 vanH protein -
Enterococcus faecium plasmid pIP816
>gi|148330|gb|AAA24789.1| (M64304) vancomycin resistance
protein [Enterococcus faecium] >gi|155041|gb|AAA65955.1|
(M97297) vanH [Transposon Tn1546]
Length = 322
Score = 131 bits (325), Expect = 2e-29
Identities = 89/276 (32%), Positives = 147/276 (53%), Gaps = 29/276 (10%)
Query: 46 IIIAPVTRITKDILERAER--LKVISCQSAGYDHVDVEEATKRGIYVTKVSGLLSEAVAE 103
I + + I+ IL +R +K IS +S G +H+D A + GI V V+ ++VA+
Sbjct: 51 ISVGHKSEISASILLALKRAGVKYISTRSIGCNHIDTTAAKRMGITVDNVA-YSPDSVAD 109
Query: 104 FALGLLISLMRKIHYADSFIREGKWESHTFVWREFKEVETLYGKEVGIVGMGAIGKAIAR 163
+ + L++ +R + S +R E H F + + L VG+VG G IGKA+
Sbjct: 110 YTMMLILMAVRNVK---SIVRSV--EKHDFRL-DSDRGKVLSDMTVGVVGTGQIGKAVIE 163
Query: 164 RLKPFGCEIYYWSRHRKEDIEREVNAKYLDLDELLEEVDIVILALPLTKETYHIINEERV 223
RL+ FGC++ +SR R + Y+ DELL+ DIV L +PL +T++II+ E++
Sbjct: 164 RLRGFGCKVLAYSR------SRSIEVNYVPFDELLQNSDIVTLHVPLNTDTHYIISHEQI 217
Query: 224 KKL-EGKYLVNIGRGALIDEKALVKAIKEGKLKGFATDVFE-----------EEPVKEHE 271
+++ +G +L+N GRG L+D LVKA++ GKL G A DV E ++P+
Sbjct: 218 QRMKQGAFLINTGRGPLVDTYELVKALENGKLGGAALDVLEGEEEFFYSDCTQKPIDNQF 277
Query: 272 LFRFKW--ETVLTPHYAGLGKDVLEDMGFRAVENLL 305
L + + ++TPH A + L D + ++N L
Sbjct: 278 LLKLQRMPNVIITPHTAYYTEQALRDTVEKTIKNCL 313
>dbj|BAA19751.1| (D85339) hydroxypyruvate reductase [Arabidopsis thaliana]
Length = 386
Score = 131 bits (325), Expect = 2e-29
Identities = 91/266 (34%), Positives = 134/266 (50%), Gaps = 28/266 (10%)
Query: 66 KVISCQSAGYDHVDVEEATKRGIYVTKVSGLLSEAVAEFALGLLISLMRKIHYADSFIRE 125
K S + GY++VDVE A K GI V G+L+E AE A L ++ R+I AD F+R
Sbjct: 88 KAFSNMAVGYNNVDVEAANKYGIAVGNTPGVLTETTAELAASLSLAAARRIVEADEFMRG 147
Query: 126 G---KWESHTFVWREFKEVETLYGKEVGIVGMGAIGKAIARRL-KPFGCEIYYWSRHRKE 181
G W H FV K G+ VG++G G IG A AR + + F + Y+ ++
Sbjct: 148 GLYEGWLPHLFVGNLLK------GQTVGVIGAGRIGSAYARMMVEGFKMNLIYFDLYQST 201
Query: 182 DIEREVNA----------------KYLDLDELLEEVDIVILALPLTKETYHIINEERVKK 225
+E+ V A + ++E+L E D++ L L K TYH++N+ER+
Sbjct: 202 RLEKFVTAYGQFLKANGEQPVTWKRASSMEEVLREADLISLHPVLDKTTYHLVNKERLAM 261
Query: 226 LEGK-YLVNIGRGALIDEKALVKAIKEGKLKGFATDVFEEEPVKEHELFRFKWETVLTPH 284
++ + LVN RG +I E ALV+ +KE + DVFEEEP + L K ++ PH
Sbjct: 262 MKKEAILVNCSRGPVIHEAALVEHLKENPMFRVGLDVFEEEPFMKPGLADMK-NAIVVPH 320
Query: 285 YAGLGKDVLEDMGFRAVENLLKVLRG 310
A K E M A N+L ++G
Sbjct: 321 IASASKWTREGMATLAALNVLGRVKG 346
>gb|AAF19554.1|AC005761_2 (AC005761) D-3-phosphoglycerate dehydrogenase [Leishmania major]
Length = 407
Score = 131 bits (325), Expect = 2e-29
Identities = 95/303 (31%), Positives = 145/303 (47%), Gaps = 13/303 (4%)
Query: 34 EELKEIIPELDGIIIAPVTRITKDILERAERLKVISCQSAGYDHVDVEEATKRGIYVTKV 93
+ L E I ++ + I T++T+ IL+ A +L I C G + VD++ AT RG+ V
Sbjct: 42 DTLLEKIRDVHFLGIRSKTQVTQAILDAAPKLLGIGCFCIGTNQVDLDYATTRGVAVFNS 101
Query: 94 SGLLSEAVAEFALGLLISLMRKIHYADSFIREGKWESHTFVWREFKEVETLYGKEVGIVG 153
+ +VAE +G +ISL RK+ + G W E + GK VGIVG
Sbjct: 102 PFANTRSVAELVIGEIISLSRKMTQRSEEVHRGVWNKTHVGCYEVR------GKTVGIVG 155
Query: 154 MGAIGKAIARRLKPFGCEIYYWSRHRKEDIEREVNAKYLDLDELLEEVDIVILALPLTKE 213
G IG + + G + ++ I K+ +++LL D V + +P T
Sbjct: 156 YGHIGSQVGVLAEALGMNVVFYDVLPTLAIGNAT--KFTHINDLLTFSDFVTIHVPETDV 213
Query: 214 TYHIINEERVKKLE-GKYLVNIGRGALIDEKALVKAIKEGKLKGFATDVFEEEPVKEHEL 272
T +I EE+++ ++ G YL+N RG ++D +AL KA++EG L G A DV+ EEP EL
Sbjct: 214 TKGMIGEEQIRLMKKGSYLINASRGTVVDLEALAKALREGHLAGAAIDVYPEEPGSNKEL 273
Query: 273 FRFKWE----TVLTPHYAGLGKDVLEDMGFRAVENLLKVLRGEIPEDLVNKEVLKVRPID 328
R + +LTPH G + E +G L K + I VN L P+D
Sbjct: 274 HRTPLQGISNVILTPHVGGSTCEAQEAIGVEVGTALAKFVTSGITAGAVNFPELVRPPVD 333
Query: 329 EVK 331
K
Sbjct: 334 RSK 336
>sp|P45250|YF56_HAEIN PUTATIVE 2-HYDROXYACID DEHYDROGENASE HI1556 >gi|1075442|pir||F64129
probable phosphoglycerate dehydrogenase homolog -
Haemophilus influenzae (strain Rd KW20)
>gi|1574400|gb|AAC23205.1| (U32830) 2-hydroxyacid
dehydrogenase [Haemophilus influenzae Rd]
Length = 315
Score = 130 bits (323), Expect = 3e-29
Identities = 90/284 (31%), Positives = 150/284 (52%), Gaps = 18/284 (6%)
Query: 30 YPSEEELKEIIPELDGIIIAPVTRITKDILERAERLKVISCQSAGYDHVDVEEATKRGIY 89
+ S E+ E + + D +I + V ++ L++ +LK+I+ + G ++VD+ A + GI
Sbjct: 31 HTSAEQTIERVKDADIVITSKVI-FDRETLQQLPKLKLIAITATGTNNVDLVAAEEMGIA 89
Query: 90 VTKVSGLLSEAVAEFALGLLISLMRKIHYADSFIR---EGKW-ESHTFVWREFKEVETLY 145
V V+G S V E +GL+ SL H ++R E KW ES F + ++ + +
Sbjct: 90 VRNVTGYSSTTVPEHVIGLIFSLK---HSLAGWLRDQTEAKWAESKQFCYFDYP-ITDVR 145
Query: 146 GKEVGIVGMGAIGKAIARRLKPFGCEIYYWSRHRKEDIEREVNAKYLDLDELLEEVDIVI 205
G +G+ G G +G + R G ++ Y + H+ + RE Y DE+L++ DIV
Sbjct: 146 GSTLGVFGKGCLGTEVGRLANAVGMKVLY-AEHKDATVCRE---GYTPFDEVLKQADIVT 201
Query: 206 LALPLTKETYHIINEERVKKLE-GKYLVNIGRGALIDEKALVKAIKEGKLKGFATDVFEE 264
L PLT+ T +IN E + K++ G +L+N GRG LIDE ALV A+K G L G A DV +
Sbjct: 202 LHCPLTETTKDLINAETLSKMKKGAFLINTGRGPLIDELALVDALKTGHLGGAALDVMVK 261
Query: 265 EPVKEHELFRFKWET----VLTPHYAGLGKDVLEDMGFRAVENL 304
EP ++ +T ++TPH A + + + ++N+
Sbjct: 262 EPPEKDNPLILAAKTMPNLIITPHIAWASDSAVTTLVGKVMQNI 305
>pir||F82022 probable glycerate dehydrogenase (EC 1.1.1.29) NMA0274 [imported] -
Neisseria meningitidis (group A strain Z2491)
>gi|7379036|emb|CAB83582.1| (AL162752) putative
glycerate dehydrogenase [Neisseria meningitidis Z2491]
Length = 322
Score = 129 bits (321), Expect = 5e-29
Identities = 80/275 (29%), Positives = 143/275 (51%), Gaps = 7/275 (2%)
Query: 46 IIIAPVTRITKDILERAERLKVISCQSAGYDHVDVEEATKRGIYVTKVSGLLSEAVAEFA 105
I+I I+ DI+ +L++I+ + G ++VD+ A G+ V V +E+VAE A
Sbjct: 52 IVITNKVMISADIIAANPQLELIAVSATGVNNVDIGAAKAAGVAVCNVRAYGNESVAEHA 111
Query: 106 LGLLISLMRKIHYADSFIREGKWESHTFVWREFKEVETLYGKEVGIVGMGAIGKAIARRL 165
L+I+LMR + + G WE F + L GK + + G G IG+ +AR
Sbjct: 112 FMLMIALMRNLPAYQRDVAAGLWEKSPFFCHYGAPIRDLNGKTLAVFGRGNIGRTLARYA 171
Query: 166 KPFGCEIYYWSRHRKEDIEREVNAKYLDLDELLEEVDIVILALPLTKETYHIINEERVKK 225
+ FG + + + H+ RE Y+ ++ ++ D++ L PL +T ++I E +++
Sbjct: 172 QAFGMRVVF-AEHKHAHAVRE---GYVSFEDAVQTADVLSLHCPLNAQTENMIGENELRQ 227
Query: 226 LE-GKYLVNIGRGALIDEKALVKAIKEGKLKGFATDVFEEEPVK-EHELFRFKW-ETVLT 282
++ G L+N GRG L+DE AL+ A+K G++ G DV EEP + + L + ++T
Sbjct: 228 MKPGAVLINCGRGGLVDENALLAALKYGQIGGAGVDVLTEEPPRGGNPLLNARLPNLIVT 287
Query: 283 PHYAGLGKDVLEDMGFRAVENLLKVLRGEIPEDLV 317
PH A ++ L+ + + N+ ++GE +V
Sbjct: 288 PHTAWASREALDRLFDILLANIHSFVKGEAQNRVV 322
>pir||JU0334 formate dehydrogenase (EC 1.2.1.2) - Pseudomonas sp
Length = 393
Score = 129 bits (320), Expect = 6e-29
Identities = 78/237 (32%), Positives = 132/237 (54%), Gaps = 7/237 (2%)
Query: 54 ITKDILERAERLKVISCQSAGYDHVDVEEATKRGIYVTKVSGLLSEAVAEFALGLLISLM 113
+T + + +A+ LK+ G DHVD++ A R + +V+ + S +VAE + +++SL+
Sbjct: 103 LTPERIAKAKNLKLALTAGIGSDHVDLQSAIDRNVVTAEVTYVNSISVAEHVVMMILSLV 162
Query: 114 RKIHYADSFIREGKWESHTFVWREFKEVETLYGKEVGIVGMGAIGKAIARRLKPFGCEIY 173
R + + R+G W V + ++E ++ VG V G IG A+ RRL PF ++
Sbjct: 163 RNYLPSHEWARKGGWNIADCVSHAY-DLEAMH---VGTVAAGRIGLAVLRRLAPFDHVLH 218
Query: 174 YWSRHR-KEDIEREVNAKY-LDLDELLEEVDIVILALPLTKETYHIINEERVKKLE-GKY 230
Y RHR E +E+E+N + +++ D+V L PL ET H+IN+E +K + G Y
Sbjct: 219 YTDRHRLPESVEKELNLTWHATREDMYPVCDVVTLNCPLHPETEHMINDETLKLFKRGAY 278
Query: 231 LVNIGRGALIDEKALVKAIKEGKLKGFATDVFEEEPVKEHELFRFKWETVLTPHYAG 287
+VN RG L D A+ +A++ G+L G+A DV+ +P + +R +TPH +G
Sbjct: 279 IVNTARGKLCDRDAVARALESGRLAGYAGDVWFPQPAPKDHPWRTMPYDGMTPHISG 335
>sp|P87228|SERA_SCHPO PUTATIVE D-3-PHOSPHOGLYCERATE DEHYDROGENASE (PGDH)
>gi|7492817|pir||T41375 probable phosphoglycerate
dehydrogenase - fission yeast (Schizosaccharomyces
pombe) >gi|2213544|emb|CAB09778.1| (Z97052) putative
phosphoglycerate dehydrogenase [Schizosaccharomyces
pombe]
Length = 466
Score = 128 bits (318), Expect = 1e-28
Identities = 106/343 (30%), Positives = 159/343 (45%), Gaps = 27/343 (7%)
Query: 4 RIGVLFKMKSKPLEELKK--YTDVVLKPYPSEEELKEIIPELDGIIIAPVTRITKDILER 61
+I +L + L LK Y LK SE++L E I + I I TR+T+ +LE
Sbjct: 57 KILLLENVNQSALSNLKDEGYQVEFLKTSMSEDDLVEKIKGVHAIGIRSKTRLTRRVLEA 116
Query: 62 AERLKVISCQSAGYDHVDVEEATKRGIYVTKVSGLLSEAVAEFALGLLISLMRKIHYADS 121
A+ L VI C G + VD++ A +RGI V S +VAE +G +ISL R++
Sbjct: 117 ADSLIVIGCFCIGTNQVDLDFAAERGIAVFNSPYANSRSVAELVIGYIISLARQVGDRSL 176
Query: 122 FIREGKWESHTFVWREFKEVETLYGKEVGIVGMGAIGKAIARRLKPFGCEIYYWSRHRKE 181
+ G+W + E + GK +GI+G G IG ++ + G + Y+
Sbjct: 177 ELHRGEWNKVSSGCWEIR------GKTLGIIGYGHIGSQLSVLAEAMGLHVVYYD---IL 227
Query: 182 DIEREVNAKYL-DLDELLEEVDIVILALPLTKETYHIINEERVKKL-EGKYLVNIGRGAL 239
I +AK L L ELL D V L +P + ET ++I+ + + EG YL+N RG +
Sbjct: 228 PIMPLGSAKQLSSLPELLHRADFVSLHVPASPETKNMISSKEFAAMKEGSYLINASRGTV 287
Query: 240 IDEKALVKAIKEGKLKGFATDVFEEEPVKE-------------HELFRFKWETVLTPHYA 286
+D ALV A K GK+ G A DV+ EP EL K +LTPH
Sbjct: 288 VDIPALVDASKSGKIAGAAIDVYPSEPAGNGKDKFVDSLNSWTSELTHCK-NIILTPHIG 346
Query: 287 GLGKDVLEDMGFRAVENLLKVLRGEIPEDLVNKEVLKVRPIDE 329
G ++ ++G E L + + VN + +R + E
Sbjct: 347 GSTEEAQYNIGIEVSEALTRYINEGNSIGAVNFPEVSLRSLTE 389
>gb|AAC23583.1| (U82965) D-lactate dehydrogenase [Streptomyces toyocaensis]
Length = 330
Score = 128 bits (318), Expect = 1e-28
Identities = 93/276 (33%), Positives = 141/276 (50%), Gaps = 25/276 (9%)
Query: 50 PVTRITKDILERAERLKVISCQSAGYDHVDVEEATKRGIYVTKVSGLLSEAVAEFALGLL 109
PVT T L R + IS +S GY+H+DVE A GI V VS ++VA++ L L+
Sbjct: 61 PVTHATLRALGRVG-VGYISTRSIGYNHIDVEYADSIGIVVENVS-YSPDSVADYTLMLM 118
Query: 110 ISLMRKIHYADSFIREGKWESHTFVWREFKEVETLYGKEVGIVGMGAIGKAIARRLKPFG 169
+ ++R A + +R + KE+ L VG+VG G IG A+ RL+ FG
Sbjct: 119 LMVLRD---AKAIVRRTDMHDYRLSEVRGKELRDL---TVGVVGTGRIGTAVLDRLRGFG 172
Query: 170 CEIYYWSRHRKEDIEREVNAKYLDLDELLEEVDIVILALPLTKETYHIINEERVKKL-EG 228
C + H +R A+Y+ LDELL D+V L PLT T+H+++++R+ ++ +G
Sbjct: 173 CRVL---AHDNHPADRPGVAEYVPLDELLRRSDVVTLHAPLTTATHHLLDQQRLARMKDG 229
Query: 229 KYLVNIGRGALIDEKALVKAIKEGKLKGFATDVFEEE-----------PVKEHELFRFKW 277
++N GRG LID +ALV ++ G+L G A DV E E P++ L R +
Sbjct: 230 ALVINTGRGGLIDTEALVHELESGRLGGAALDVVEGEEGIFYADCRDRPMESKALLRLQE 289
Query: 278 --ETVLTPHYAGLGKDVLEDMGFRAVENLLKVLRGE 311
++TPH A L D ++ N L + E
Sbjct: 290 LPNALITPHTAYYTDHALRDTVENSLTNCLTFRKQE 325
>sp|Q47748|VANH_ENTFA D-SPECIFIC ALPHA-KETO ACID DEHYDROGENASE (VANCOMYCIN B-TYPE
RESISTANCE PROTEIN VANHB) >gi|1209530|gb|AAB05626.1|
(U35369) D-2-hydroxyacid dehydrogenase [Enterococcus
faecalis]
Length = 323
Score = 127 bits (317), Expect = 1e-28
Identities = 90/265 (33%), Positives = 139/265 (51%), Gaps = 39/265 (14%)
Query: 65 LKVISCQSAGYDHVDVEEATKRGIYVTKVSGLLSEAVAEFALGLLISLMRKIHYADSFIR 124
+K IS +S G +H+D A + GI V V+ ++VA++AL L++ IR
Sbjct: 73 VKYISTRSIGCNHIDTTAAERMGISVGTVA-YSPDSVADYALMLMLMA----------IR 121
Query: 125 EGKWESHTFVWREFKEVETLYGKE-----VGIVGMGAIGKAIARRLKPFGCEIYYWSRHR 179
K H + F+ ++ + GKE VG++G G IG+A+ +RL+ FGC + + R
Sbjct: 122 GAKSTIHAVAQQNFR-LDCVRGKELRDMTVGVIGTGHIGQAVVKRLRGFGCRVLAYDNSR 180
Query: 180 KEDIEREVNAKYLDLDELLEEVDIVILALPLTKETYHIINEERVKKL-EGKYLVNIGRGA 238
K + A Y+ LDELL+ DIV L +PL +T H+I + + ++ +G +L+N GRGA
Sbjct: 181 K------IEADYVQLDELLKNSDIVTLHVPLCADTRHLIGQSEIGEMKQGAFLINTGRGA 234
Query: 239 LIDEKALVKAIKEGKLKGFATDVFEEE----------PVKEH----ELFRFKWETVLTPH 284
L+D +LV+A+ GKL G A DV E E V +H +L R ++TPH
Sbjct: 235 LVDTGSLVEALGSGKLGGAALDVLEGEDQFVYTDCSQKVLDHPFLSQLLRMP-NVIITPH 293
Query: 285 YAGLGKDVLEDMGFRAVENLLKVLR 309
A + VL D + + N L R
Sbjct: 294 TAYYTERVLRDTTEKTIRNCLNFER 318
>pir||S68164 glycerate dehydrogenase (EC 1.1.1.29) splice form HPR1, microbody -
cucurbit >gi|1304042|dbj|BAA08410.1| (D49432)
hydroxypyruvate reductase [Cucurbita sp.]
Length = 386
Score = 127 bits (316), Expect = 2e-28
Identities = 94/286 (32%), Positives = 142/286 (48%), Gaps = 33/286 (11%)
Query: 66 KVISCQSAGYDHVDVEEATKRGIYVTKVSGLLSEAVAEFALGLLISLMRKIHYADSFIRE 125
K S + GY++VDV A K GI V G+L+E AE A L ++ R+I AD F+R
Sbjct: 88 KAFSNMAVGYNNVDVNAANKYGIAVGNTPGVLTETTAELAASLSLAAARRIVEADEFMRA 147
Query: 126 GK---WESHTFVWREFKEVETLYGKEVGIVGMGAIGKAIARRL-KPFGCEIYYWSRHRKE 181
G W + FV K G+ VG++G G IG A AR + + F + Y+ ++
Sbjct: 148 GHYDGWLPNLFVGNLLK------GQTVGVIGAGRIGSAYARMMVEGFKMNLIYFDLYQST 201
Query: 182 DIEREVNA----------------KYLDLDELLEEVDIVILALPLTKETYHIINEERVKK 225
+E+ V A + +DE+L E D++ L L K T+H++N+E +K
Sbjct: 202 RLEKFVTAYGEFLKANGEVPVTWRRASSMDEVLREADVISLHPVLDKTTFHLVNKESLKA 261
Query: 226 L-EGKYLVNIGRGALIDEKALVKAIKEGKLKGFATDVFEEEPVKEHELFRFKWETVLTPH 284
+ + L+N RG +IDE ALV+ +KE + DVFE+EP + L K ++ PH
Sbjct: 262 MKKDAILINCSRGPVIDEAALVEHLKENPMFRVGLDVFEDEPYMKPGLADMK-NAIIVPH 320
Query: 285 YAGLGKDVLEDMGFRAVENLLKVLRGEIPEDLVNKEVLKVRP-IDE 329
A K E M A N+L G+I + V + +V P +DE
Sbjct: 321 IASASKWTREGMATLAALNVL----GKIKQYPVWADPNRVEPFLDE 362
>pir||S68165 glycerate dehydrogenase (EC 1.1.1.29) splice form HPR2 - cucurbit
>gi|1304044|dbj|BAA08411.1| (D49433) hydroxypyruvate
reductase [Cucurbita sp.]
Length = 381
Score = 127 bits (316), Expect = 2e-28
Identities = 94/286 (32%), Positives = 142/286 (48%), Gaps = 33/286 (11%)
Query: 66 KVISCQSAGYDHVDVEEATKRGIYVTKVSGLLSEAVAEFALGLLISLMRKIHYADSFIRE 125
K S + GY++VDV A K GI V G+L+E AE A L ++ R+I AD F+R
Sbjct: 88 KAFSNMAVGYNNVDVNAANKYGIAVGNTPGVLTETTAELAASLSLAAARRIVEADEFMRA 147
Query: 126 GK---WESHTFVWREFKEVETLYGKEVGIVGMGAIGKAIARRL-KPFGCEIYYWSRHRKE 181
G W + FV K G+ VG++G G IG A AR + + F + Y+ ++
Sbjct: 148 GHYDGWLPNLFVGNLLK------GQTVGVIGAGRIGSAYARMMVEGFKMNLIYFDLYQST 201
Query: 182 DIEREVNA----------------KYLDLDELLEEVDIVILALPLTKETYHIINEERVKK 225
+E+ V A + +DE+L E D++ L L K T+H++N+E +K
Sbjct: 202 RLEKFVTAYGEFLKANGEVPVTWRRASSMDEVLREADVISLHPVLDKTTFHLVNKESLKA 261
Query: 226 L-EGKYLVNIGRGALIDEKALVKAIKEGKLKGFATDVFEEEPVKEHELFRFKWETVLTPH 284
+ + L+N RG +IDE ALV+ +KE + DVFE+EP + L K ++ PH
Sbjct: 262 MKKDAILINCSRGPVIDEAALVEHLKENPMFRVGLDVFEDEPYMKPGLADMK-NAIIVPH 320
Query: 285 YAGLGKDVLEDMGFRAVENLLKVLRGEIPEDLVNKEVLKVRP-IDE 329
A K E M A N+L G+I + V + +V P +DE
Sbjct: 321 IASASKWTREGMATLAALNVL----GKIKQYPVWADPNRVEPFLDE 362
>sp|P13443|DHGY_CUCSA GLYCERATE DEHYDROGENASE (NADH-DEPENDENT HYDROXYPYRUVATE REDUCTASE)
(HPR) (GDH) >gi|65955|pir||DEKVG glycerate dehydrogenase
(EC 1.1.1.29) - cucumber >gi|18264|emb|CAA41434.1|
(X58542) NADH-dependent hydroxypyruvate reductase
[Cucumis sativus] >gi|18275|emb|CAA32764.1| (X14609)
NAPH-dependent hydroxypyruvate reductase (AA 1 - 382)
[Cucumis sativus]
Length = 382
Score = 127 bits (315), Expect = 2e-28
Identities = 85/266 (31%), Positives = 133/266 (49%), Gaps = 28/266 (10%)
Query: 66 KVISCQSAGYDHVDVEEATKRGIYVTKVSGLLSEAVAEFALGLLISLMRKIHYADSFIRE 125
K S + GY++VDV A K G+ V G+L+E AE A L ++ R+I AD F+R
Sbjct: 88 KAFSNMAVGYNNVDVNAANKYGVAVGNTPGVLTETTAELAASLSLAAARRIVEADEFMRA 147
Query: 126 GK---WESHTFVWREFKEVETLYGKEVGIVGMGAIGKAIARRL-KPFGCEIYYWSRHRKE 181
G+ W + FV K G+ VG++G G IG A AR + + F + Y+ ++
Sbjct: 148 GRYDGWLPNLFVGNLLK------GQTVGVIGAGRIGSAYARMMVEGFKMNLIYFDLYQST 201
Query: 182 DIEREVNA----------------KYLDLDELLEEVDIVILALPLTKETYHIINEERVKK 225
+E+ V A + +DE+L E D++ L L K T+H++N+E +K
Sbjct: 202 RLEKFVTAYGEFLKANGEAPVTWRRASSMDEVLREADVISLHPVLDKTTFHLVNKESLKA 261
Query: 226 L-EGKYLVNIGRGALIDEKALVKAIKEGKLKGFATDVFEEEPVKEHELFRFKWETVLTPH 284
+ + L+N RG +IDE ALV +++ + DVFE+EP + L K ++ PH
Sbjct: 262 MKKDAILINCSRGPVIDEAALVDHLRDNPMFRVGLDVFEDEPYMKPGLADMK-NAIIVPH 320
Query: 285 YAGLGKDVLEDMGFRAVENLLKVLRG 310
A K E M A N+L ++G
Sbjct: 321 IASASKWTREGMATLAALNVLGKIKG 346
>gi|9631622 contains D-isomer specific 2-hydroxyacid dehydrogenase signature;
similar to E. coli D-lactate dehydrogenase, corresponds
to Swiss-Prot Accession Number P52643 [Paramecium
bursaria Chlorella virus 1] >gi|7461865|pir||T17543
probable D-lactate dehydrogenase (EC 1.1.1.28) -
Chlorella virus PBCV-1 >gi|624075|gb|AAC96421.1|
(U42580) contains D-isomer specific 2-hydroxyacid
dehydrogenase signature; similar to E. coli D-lactate
dehydrogenase, corresponds to Swiss-Prot Accession
Number P52643 [Paramecium bursaria Chlorella virus 1]
Length = 363
Score = 127 bits (315), Expect = 2e-28
Identities = 83/283 (29%), Positives = 144/283 (50%), Gaps = 32/283 (11%)
Query: 49 APVTRITKDILERAERLKVISCQSAGYDHVDVEEATKRGIYVTKVSGLLSEAVAEFALGL 108
APV I K+ + I+ + AG+D +D+E A + G V +V +VAE AL
Sbjct: 85 APVLDILKNC-----GVSSITLRCAGFDRLDIEYAKELGFNVYRVPAYSPRSVAELALTH 139
Query: 109 LISLMRKIHYADSFIREGKWESHTFVWREFKEVETLYGKEVGIVGMGAIGKAIARRLKPF 168
+++L R I ++ G + V RE + K +GI+G G I + + +KP
Sbjct: 140 MMALSRNIQLVLPRVKTGNYTMEGLVGREITD------KTIGIIGTGKIAQEFIKLVKPM 193
Query: 169 GCEIYYWSRHRKEDIEREVNAKYLDLDELLEEVDIVILALPLTKETYHIINEERVKKL-E 227
I + + + DI +E+ +Y+ L ++++E D++ L PL K T+H+INE+ +K + +
Sbjct: 194 AGRIIAYDVY-ENDIVKEMGVEYMSLPDVIKESDVLSLHCPLMKSTFHMINEDTLKTMKK 252
Query: 228 GKYLVNIGRGALIDEKALVKAIKEGKLKGFATDVFEEE-----------PVKEHELFRFK 276
++N RG LID +AL+ A++ G + G A DV+E E P+++ F K
Sbjct: 253 TAVIINTARGGLIDTEALIDALESGVISGCAMDVYEHESGLFFTDRAVLPIEDRMKFWDK 312
Query: 277 W--------ETVLTPHYAGLGKDVLEDMGFRAVENLLKVLRGE 311
+++PH A L K+ L+++ +ENL +GE
Sbjct: 313 KFARLANLPNAIVSPHVAFLTKEALKNIADTTIENLTSAFKGE 355
>pir||T42743 hypothetical protein - fission yeast (Schizosaccharomyces pombe)
>gi|1749578|dbj|BAA13847.1| (D89185) similar to
Saccharomyces cerevisiae ORF YNL274C, EMBL Accession
Number Z71550 [Schizosaccharomyces pombe]
Length = 334
Score = 126 bits (314), Expect = 3e-28
Identities = 86/255 (33%), Positives = 133/255 (51%), Gaps = 12/255 (4%)
Query: 65 LKVISCQSAGYDHVDVEEATKRGIYVTKVSGLLSEAVAEFALGLLISLMRKIHYADSFIR 124
+K I AGY+ VDV T RGI V+ V + +A A+ + L++ +R + +
Sbjct: 81 VKFICHLGAGYETVDVAACTARGIQVSHVPKAVDDATADVGIFLMLGALRGFNQGIFELH 140
Query: 125 EGKWESHTFVWREFKEVETLYGKEVGIVGMGAIGKAIARRLKPFGCEIYYWSRHRKEDIE 184
+ W ++ K GK +GI+G+G IGK +A+R + F +I Y +R + E
Sbjct: 141 KNNWNANC------KPSHDPEGKTLGILGLGGIGKTMAKRARAFDMKIVYHNRTPLPEEE 194
Query: 185 REVNAKYLDLDELLEEVDIVILALPLTKETYHIINEERVKKLE-GKYLVNIGRGALIDEK 243
E A+++ D+LL + D++ L LPL T HII + +K++ G +VN RGA++DE
Sbjct: 195 AE-GAEFVSFDDLLAKSDVLSLNLPLNAHTRHIIGKPEFQKMKRGIVIVNTARGAVMDEA 253
Query: 244 ALVKAIKEGKLKGFATDVFEEEPVKEHELFRFKWETVLTPHYAGLGKDVLEDMGFRAVEN 303
ALV+A+ EG + DVFEEEP K H + +L PH LG + LE
Sbjct: 254 ALVEALDEGIVYSAGLDVFEEEP-KIHPGLLENEKVILLPH---LGTNSLETQYKMECAV 309
Query: 304 LLKVLRGEIPEDLVN 318
L+ V G + + L N
Sbjct: 310 LMNVKNGIVNDSLPN 324
>pir||T41705 probable 2-hydroxyacid dehydrogenase - fission yeast
(Schizosaccharomyces pombe) >gi|3395556|emb|CAA20140.1|
(AL031180) putative 2-hydroxyacid dehydrogenase
[Schizosaccharomyces pombe]
Length = 334
Score = 126 bits (314), Expect = 3e-28
Identities = 86/255 (33%), Positives = 133/255 (51%), Gaps = 12/255 (4%)
Query: 65 LKVISCQSAGYDHVDVEEATKRGIYVTKVSGLLSEAVAEFALGLLISLMRKIHYADSFIR 124
+K I AGY+ VDV T RGI V+ V + +A A+ + L++ +R + +
Sbjct: 81 VKFICHLGAGYETVDVAACTARGIQVSHVPKAVDDATADVGIFLMLGALRGFNQGIFELH 140
Query: 125 EGKWESHTFVWREFKEVETLYGKEVGIVGMGAIGKAIARRLKPFGCEIYYWSRHRKEDIE 184
+ W ++ K GK +GI+G+G IGK +A+R + F +I Y +R + E
Sbjct: 141 KNNWNANC------KPSHDPEGKTLGILGLGGIGKTMAKRARAFDMKIVYHNRTPLPEEE 194
Query: 185 REVNAKYLDLDELLEEVDIVILALPLTKETYHIINEERVKKLE-GKYLVNIGRGALIDEK 243
E A+++ D+LL + D++ L LPL T HII + +K++ G +VN RGA++DE
Sbjct: 195 AE-GAEFVSFDDLLAKSDVLSLNLPLNAHTRHIIGKPEFQKMKRGIVIVNTARGAVMDEA 253
Query: 244 ALVKAIKEGKLKGFATDVFEEEPVKEHELFRFKWETVLTPHYAGLGKDVLEDMGFRAVEN 303
ALV+A+ EG + DVFEEEP K H + +L PH LG + LE
Sbjct: 254 ALVEALDEGIVYSAGLDVFEEEP-KIHPGLLENEKVILLPH---LGTNSLETQYKMECAV 309
Query: 304 LLKVLRGEIPEDLVN 318
L+ V G + + L N
Sbjct: 310 LMNVKNGIVNDSLPN 324
>pdb|1GDH|A Chain A, D-Glycerate Dehydrogenase (Apo Form) (E.C.1.1.1.29)
>gi|494036|pdb|1GDH|B Chain B, D-Glycerate Dehydrogenase
(Apo Form) (E.C.1.1.1.29)
Length = 320
Score = 125 bits (311), Expect = 7e-28
Identities = 96/317 (30%), Positives = 152/317 (47%), Gaps = 14/317 (4%)
Query: 2 KPRIGVLFKMKSKPLEELKKYTDVVLK---PYPSEEELKEIIPELDGIIIAPVTRITKDI 58
K +I + + + + ++ DV+ P + +E+ E +D ++I + K++
Sbjct: 1 KKKILITWPLPEAAMARARESYDVIAHGDDPKITIDEMIETAKSVDALLITLNEKCRKEV 60
Query: 59 LERA-ERLKVISCQSAGYDHVDVEEATKRGIYVTKVSGLLSEAVAEFALGLLISLMRKIH 117
++R E +K IS S G+DH+D++ RGI V ++ A AE A+ LL+ R+
Sbjct: 61 IDRIPENIKCISTYSIGFDHIDLDACKARGIKVGNAPHGVTVATAEIAMLLLLGSARRAG 120
Query: 118 YADSFIREGKWESHTFVWREFKEV-ETLYGKEVGIVGMGAIGKAIARRLKPFGCEIYYWS 176
+ IR W W + V E L K +GI G G+IG+A+A+R + F +I Y+
Sbjct: 121 EGEKMIRTRSWPG----WEPLELVGEKLDNKTLGIYGFGSIGQALAKRAQGFDMDIDYFD 176
Query: 177 RHR-KEDIEREVNAKYLD-LDELLEEVDIVILALPLTKETYHIINEERVKKL-EGKYLVN 233
HR E A + D LD LL L P T ET + N+ +K L +G +VN
Sbjct: 177 THRASSSDEASYQATFHDSLDSLLSVSQFFSLNAPSTPETRYFFNKATIKSLPQGAIVVN 236
Query: 234 IGRGALIDEKALVKAIKEGKLKGFATDVFEEEPVKEHELFRFKWETVLTPHYAGLGKDVL 293
RG L+D + +V A++ G+L DVF EP +E + T L PH
Sbjct: 237 TARGDLVDNELVVAALEAGRLAYAGFDVFAGEP-NINEGYYDLPNTFLFPHIGSAATQAR 295
Query: 294 EDMGFRAVENLLKVLRG 310
EDM +A +L+ L G
Sbjct: 296 EDMAHQA-NDLIDALFG 311
>sp|P36234|DHGY_HYPME GLYCERATE DEHYDROGENASE (NADH-DEPENDENT HYDROXYPYRUVATE REDUCTASE)
(HPR) (GDH) (HYDROXYPYRUVATE DEHYDROGENASE) (GLYOXYLATE
REDUCTASE)
Length = 322
Score = 125 bits (311), Expect = 7e-28
Identities = 96/317 (30%), Positives = 152/317 (47%), Gaps = 14/317 (4%)
Query: 2 KPRIGVLFKMKSKPLEELKKYTDVVLK---PYPSEEELKEIIPELDGIIIAPVTRITKDI 58
K +I + + + + ++ DV+ P + +E+ E +D ++I + K++
Sbjct: 3 KKKILITWPLPEAAMARARESYDVIAHGDDPKITIDEMIETAKSVDALLITLNEKCRKEV 62
Query: 59 LERA-ERLKVISCQSAGYDHVDVEEATKRGIYVTKVSGLLSEAVAEFALGLLISLMRKIH 117
++R E +K IS S G+DH+D++ RGI V ++ A AE A+ LL+ R+
Sbjct: 63 IDRIPENIKCISTYSIGFDHIDLDACKARGIKVGNAPHGVTVATAEIAMLLLLGSARRAG 122
Query: 118 YADSFIREGKWESHTFVWREFKEV-ETLYGKEVGIVGMGAIGKAIARRLKPFGCEIYYWS 176
+ IR W W + V E L K +GI G G+IG+A+A+R + F +I Y+
Sbjct: 123 EGEKMIRTRSWPG----WEPLELVGEKLDNKTLGIYGFGSIGQALAKRAQGFDMDIDYFD 178
Query: 177 RHR-KEDIEREVNAKYLD-LDELLEEVDIVILALPLTKETYHIINEERVKKL-EGKYLVN 233
HR E A + D LD LL L P T ET + N+ +K L +G +VN
Sbjct: 179 THRASSSDEASYQATFHDSLDSLLSVSQFFSLNAPSTPETRYFFNKATIKSLPQGAIVVN 238
Query: 234 IGRGALIDEKALVKAIKEGKLKGFATDVFEEEPVKEHELFRFKWETVLTPHYAGLGKDVL 293
RG L+D + +V A++ G+L DVF EP +E + T L PH
Sbjct: 239 TARGDLVDNELVVAALEAGRLAYAGFDVFAGEP-NINEGYYDLPNTFLFPHIGSAATQAR 297
Query: 294 EDMGFRAVENLLKVLRG 310
EDM +A +L+ L G
Sbjct: 298 EDMAHQA-NDLIDALFG 313
>sp|Q03134|FDH_EMENI PROBABLE FORMATE DEHYDROGENASE (NAD-DEPENDENT FORMATE
DEHYDROGENASE) (FDH) >gi|419908|pir||S30088 aciA protein
- Emericella nidulans >gi|5545|emb|CAA77687.1| (Z11612)
AciA [Emericella nidulans] >gi|384296|prf||1905380A aciA
gene [Emericella nidulans]
Length = 377
Score = 125 bits (310), Expect = 9e-28
Identities = 80/243 (32%), Positives = 132/243 (53%), Gaps = 28/243 (11%)
Query: 54 ITKDILERAERLKVISCQSAGYDHVDVEEATKR--GIYVTKVSGLLSEAVAEFALGLLIS 111
+T + L +A+ LK+ G DHVD++ A K GI V +V+G +VAE + ++
Sbjct: 70 LTAERLAKAKNLKLAVTAGIGSDHVDLDAANKTNGGITVAEVTGSNVVSVAEHVVMTILL 129
Query: 112 LMRKIHYADSFIREGKWESHTFVWREFKEVETLYGKEVGIVGMGAIGKAIARRLKPFGCE 171
L+R A IR G W EF L K VG VG+G IG+ + RRLKPF C+
Sbjct: 130 LVRNFVPAHDQIRNGDWNVAAVAKNEFD----LENKVVGTVGVGRIGERVLRRLKPFDCK 185
Query: 172 --IYYWSRHRKEDIEREVNAKYLD-LDELLEEVDIVILALPLTKETYHIINEERVKKLE- 227
+YY + + ++E+E+ A+ +D L+E++ + D+V + PL ++T + N+E + K++
Sbjct: 186 ELLYYDYQPLRPEVEKEIGARRVDSLEEMVSQCDVVTINCPLHEKTRGLFNKELISKMKP 245
Query: 228 -----------------GKYLVNIGRGALIDEKALVKAIKEGKLKGFATDVFEEEPV-KE 269
G +LVN RGA++ ++ + +A+K G L+G+ DV+ +P KE
Sbjct: 246 GKSALLYLIIPMLMYHKGSWLVNTARGAIVVKEDVAEALKSGHLRGYGGDVWFPQPAPKE 305
Query: 270 HEL 272
H L
Sbjct: 306 HPL 308
>gb|AAD23831.1|AF123482_1 (AF123482) NAD-dependent formate dehydrogenase [Mycosphaerella
graminicola]
Length = 417
Score = 125 bits (310), Expect = 9e-28
Identities = 80/250 (32%), Positives = 135/250 (54%), Gaps = 16/250 (6%)
Query: 54 ITKDILERAERLKVISCQSAGYDHVDVEEATKR--GIYVTKVSGLLSEAVAEFALGLLIS 111
+T + L +A++LK+ G DHVD+ A K GI V +V+G +VAE + ++
Sbjct: 123 LTAERLAKAKKLKIAVTAGIGSDHVDLNAANKTNGGITVAEVTGSNVVSVAEHVVMTMLV 182
Query: 112 LMRKIHYADSFIREGKWESHTFVWREFKEVETLYGKEVGIVGMGAIGKAIARRLKPFGCE 171
L+R A I G W E+ L GK VG V +G IG+ + RRLKPF C+
Sbjct: 183 LVRNFVPAHEQIAAGDWNVAAVAKNEYD----LEGKVVGTVAVGRIGERVLRRLKPFDCK 238
Query: 172 --IYYWSRHRKEDIEREVNAKYLD-LDELLEEVDIVILALPLTKETYHIINEERVKKLE- 227
+Y+ + ++E+E+ + +D L+E+L + D+V + PL ++T + N+E + K++
Sbjct: 239 ELLYFDYQALAPEVEKEIGCRRVDTLEEMLAQCDVVTINCPLHEKTRGLFNKELISKMKK 298
Query: 228 GKYLVNIGRGALIDEKALVKAIKEGKLKGFATDVFEEEPVKEHELFR------FKWETVL 281
G +LVN RGA++ ++ + A+K G+L+G+ DV+ +PV FR + +
Sbjct: 299 GSWLVNTARGAIVVKEEVAAALKFGQLRGYGGDVWFPKPVPADHPFRTASYSTWGGGNAM 358
Query: 282 TPHYAGLGKD 291
PH +G D
Sbjct: 359 VPHMSGTSID 368
>pir||H81245 glycerate dehydrogenase NMB0029 [imported] - Neisseria meningitidis
(group B strain MD58) >gi|7225248|gb|AAF40500.1|
(AE002361) glycerate dehydrogenase [Neisseria
meningitidis MC58]
Length = 317
Score = 125 bits (310), Expect = 9e-28
Identities = 79/275 (28%), Positives = 140/275 (50%), Gaps = 7/275 (2%)
Query: 46 IIIAPVTRITKDILERAERLKVISCQSAGYDHVDVEEATKRGIYVTKVSGLLSEAVAEFA 105
I+I I+ DI+ +L++I+ + G ++VD+ A G+ V V +E+VAE A
Sbjct: 47 IVITNKVMISADIIAANPQLELIAVSATGVNNVDIGAAKAAGVAVCNVRAYGNESVAEHA 106
Query: 106 LGLLISLMRKIHYADSFIREGKWESHTFVWREFKEVETLYGKEVGIVGMGAIGKAIARRL 165
L+I+LMR + + G WE F + L GK + + G G IG+ +A
Sbjct: 107 FMLMIALMRNLPAYQRDVAAGLWEKSPFFCHYGAPIRDLNGKTLAVFGRGNIGRTLAGYA 166
Query: 166 KPFGCEIYYWSRHRKEDIEREVNAKYLDLDELLEEVDIVILALPLTKETYHIINEERVKK 225
+ FG + + + H+ RE Y+ ++ + D++ L PL +T ++I E +++
Sbjct: 167 QAFGMGVVF-AEHKHASAVRE---GYVSFEDAVRAADVLSLHCPLNAQTENMIGENELRQ 222
Query: 226 LE-GKYLVNIGRGALIDEKALVKAIKEGKLKGFATDVFEEEPVKE-HELFRFKW-ETVLT 282
++ G L+N GRG L+DE AL+ A+K G++ G DV EP K + L + ++T
Sbjct: 223 MKPGAVLINCGRGGLVDENALLAALKYGQIGGAGVDVLTNEPPKNGNPLLNARLPNLIVT 282
Query: 283 PHYAGLGKDVLEDMGFRAVENLLKVLRGEIPEDLV 317
PH A ++ L+ + + N+ ++GE +V
Sbjct: 283 PHTAWASREALDRLFDILLANIHAFVKGEAQNRVV 317
>gb|AAF53080.1| (AE003631) CG6287 gene product [Drosophila melanogaster]
Length = 332
Score = 124 bits (308), Expect = 2e-27
Identities = 86/298 (28%), Positives = 144/298 (47%), Gaps = 16/298 (5%)
Query: 34 EELKEIIPELDGIIIAPVTRITKDILERAE-RLKVISCQSAGYDHVDVEEATKRGIYVTK 92
EEL + + D I+ T+IT ++L LKV+ AG D++DV AT + + V
Sbjct: 38 EELCQEVKNFDAAIVRSDTKITAEVLAAGSGSLKVVGRAGAGVDNIDVPAATAQNVVVLN 97
Query: 93 VSGLLSEAVAEFALGLLISLMRKIHYADSFIREGKWESHTFVWREFKEVETLYGKEVGIV 152
G S + E L+ SL R + A ++EG+W+ + E LYGK + ++
Sbjct: 98 TPGGNSISACELTCILIGSLARPVVPAGQSMKEGRWDRKLYAGTE------LYGKTLAVL 151
Query: 153 GMGAIGKAIARRLKPFGCEIYYWSRHRKEDIEREVNAKYLDLDELLEEVDIVILALPLTK 212
G+G IG+ +A R+K +G I + E + + + L+E+ D + + PL
Sbjct: 152 GLGRIGREVAIRMKTWGMRIIGYDPITTEAEAKAAGIEKMTLEEIWPLADYITVHTPLIP 211
Query: 213 ETYHIINEERVKKL-EGKYLVNIGRGALIDEKALVKAIKEGKLKGFATDVFEEEPVKE-- 269
T ++I+ E + K +G +VN+ RG +IDE+A++ ++ GK+ G A DV+ EEP K
Sbjct: 212 ATRNLISAETLAKCKQGVKVVNVARGGIIDEQAVLDGLESGKVAGAAFDVYPEEPPKSAV 271
Query: 270 HELFRFKWETVLTPHYAGLGKDVLEDMGFRAVENLLKVLRGEIPE-----DLVNKEVL 322
+ + V TPH + + E + L G P+ ++NKE L
Sbjct: 272 TKALISHPKVVATPHLGASTSEAQVRVAVEVAEQFI-ALNGTSPKYTSYAGVINKEAL 328
>pir||F69895 phosphoglycerate dehydrogenase homolog yoaD - Bacillus subtilis
>gi|2619022|gb|AAB84446.1| (AF027868) YoaD [Bacillus
subtilis] >gi|2634250|emb|CAB13749.1| (Z99114) similar
to phosphoglycerate dehydrogenase [Bacillus subtilis]
Length = 344
Score = 123 bits (306), Expect = 3e-27
Identities = 91/298 (30%), Positives = 153/298 (50%), Gaps = 12/298 (4%)
Query: 33 EEELKEIIPELDGI-IIAPVTRITKDILERAERLKVISCQSAGYDHVDVEEATKRGIYVT 91
E+EL +++ + +I + ++T + L + +VDV A+KRGI V
Sbjct: 49 EDELIQLLKATNATGLITELDQVTDSVFASVPELSFVGVCRGMPSNVDVAAASKRGIPVF 108
Query: 92 KVSGLLSEAVAEFALGLLISLMRKIHYADSFIREGKWES-HTFVWREFKEVETLYGKEVG 150
G ++AVAE +G +IS +R ++ ++++G+W+S + + +FK E L GK VG
Sbjct: 109 YTPGRNAQAVAEMFIGNVISFLRHTSASNQWLKDGEWDSDYLQAYVKFKGNE-LTGKTVG 167
Query: 151 IVGMGAIGKAIARRLKPFGCEIYYWSRHRKEDIEREVNAKYLDLDELLEEVDIVILALPL 210
++G GA+G+ IA+ L F C+I Y+ + ++D A L + + DIV + LP
Sbjct: 168 MIGFGAVGQRIAKLLTAFDCKIKYYDPYIQDDHPLYEKA---SLKTVFSDSDIVSVHLPR 224
Query: 211 TKETYHIINEERVKKL-EGKYLVNIGRGALIDEKALVKAIKEGKLKGFATDVFEEEPVKE 269
T+ET +I+ + + E VN R +++ + L+ +KE K+ G DVF EP +E
Sbjct: 225 TEETLGLIDRQYFDLMKESAIFVNTSRAVVVNREDLLFVLKEHKISGAILDVFYHEPPEE 284
Query: 270 HELFRFKWETVL-TPHYAGLGKDVLEDMGFRAVENLLKVLRGEIP---EDLVNKEVLK 323
+ VL TPH AG +V ED + LK +GE + + NK+ LK
Sbjct: 285 SDYELISLPNVLATPHLAGATFEV-EDHHVTILNKALKKWKGEKTLNIQTMYNKDALK 341
>gb|AAC46259.1| (AF006000) D-3-phosphoglycerate dehydrogenase homolog [Bordetella
pertussis]
Length = 399
Score = 123 bits (305), Expect = 3e-27
Identities = 95/308 (30%), Positives = 150/308 (47%), Gaps = 24/308 (7%)
Query: 22 YTDVVLKP--YPSEEELKEIIPELDGIIIAPVTRITKDILERAERLKVISCQSAGYDHVD 79
YTD+V PS E L+E + + + I T + D+L L+V+ C G + VD
Sbjct: 23 YTDIVAHAAALPSGE-LREALRGAEVVGIRSRTHLDADLLAANPDLRVVGCFCIGTNQVD 81
Query: 80 VEEATKRGIYVTKVSGLLSEAVAEFALGLLISLMRKIHYADSFIREGKWESHTFVWREFK 139
++ A RG+ V + +VAE LG I L+R+I ++ + G W+ E +
Sbjct: 82 LDAAMMRGVPVFNAPFSNTRSVAELVLGETILLLRRIPEKNARVHLGHWDKSAAGAYEAR 141
Query: 140 EVETLYGKEVGIVGMGAIGKAIARRLKPFGCEIYYWSRHRKEDIEREV---NAKYL-DLD 195
GK +GIVG G IG I+ + G + ++ D+E ++ NA+ L
Sbjct: 142 ------GKTLGIVGYGNIGSQISTLAEAIGMRVVFF------DVEAKLPLGNARAAGSLA 189
Query: 196 ELLEEVDIVILALPLTKETYHIINEERVKKLE-GKYLVNIGRGALIDEKALVKAIKEGKL 254
ELLE+ D+V L +P K T +I+N + + +++ G L+N RG ++D +AL A+ G L
Sbjct: 190 ELLEQADVVTLHVPGGKSTQNIVNADTLARMKRGAILINASRGTVVDIQALHDALASGHL 249
Query: 255 KGFATDVFEEEPVKEHELFRFKW----ETVLTPHYAGLGKDVLEDMGFRAVENLLKVLRG 310
G A DVF EP E VLTPH G ++ E++G E L++ L+
Sbjct: 250 AGAALDVFPTEPKSADEPLASPLIGMPNVVLTPHIGGSTQESQENIGREVAEKLVRFLQA 309
Query: 311 EIPEDLVN 318
+ VN
Sbjct: 310 GTTKSAVN 317
>gb|AAF36802.1|AF155139_1 (AF155139) putative lactate dehydrogenase VanHE [Paenibacillus
popilliae]
Length = 322
Score = 123 bits (305), Expect = 3e-27
Identities = 82/264 (31%), Positives = 137/264 (51%), Gaps = 27/264 (10%)
Query: 65 LKVISCQSAGYDHVDVEEATKRGIYVTKVSGLLSEAVAEFALGLLISLMRKIHYADSFIR 124
+K IS +S G +H+DV+ A GI V V+ ++VA++ L L++ +R S
Sbjct: 72 VKYISTRSIGCNHIDVKAAESMGIAVGNVA-YSPDSVADYTLMLMLMAIRNAKSIVSRAE 130
Query: 125 EGKWESHTFVWREFKEVETLYGKEVGIVGMGAIGKAIARRLKPFGCEIYYWSRHRKEDIE 184
+ + T +E +E+ VG++G G IGKA+ RL+ FGC + +
Sbjct: 131 KYDFRLDTVPGKELREMT------VGVLGTGQIGKAVIERLRGFGCHVLAYGH------S 178
Query: 185 REVNAKYLDLDELLEEVDIVILALPLTKETYHIINEERVKKL-EGKYLVNIGRGALIDEK 243
+E A Y+ L+ELL++ DI+ + +PL +TYH+I E+++ + +G +L+N RG L+D
Sbjct: 179 KEAAANYVSLNELLQKSDILTIHVPLGTDTYHMIGHEQIEAVKQGAFLINTARGGLVDTG 238
Query: 244 ALVKAIKEGKLKGFATDVFE-----------EEPVKEHELFRFKW--ETVLTPHYAGLGK 290
AL+KA++ G+L G A DV E ++P+ L + ++TPH A
Sbjct: 239 ALIKALENGRLGGAALDVLEGEEGLFYFDCTQKPIDNQLLLKLHKMPNVIITPHTAYYTG 298
Query: 291 DVLEDMGFRAVENLLKVLRGEIPE 314
L D + + N L+ R E E
Sbjct: 299 RALYDTVEKTILNCLEFERRETLE 322
>emb|CAB61228.1| (Y15705) vanh protein [Bacillus circulans]
Length = 322
Score = 122 bits (303), Expect = 6e-27
Identities = 89/281 (31%), Positives = 145/281 (50%), Gaps = 39/281 (13%)
Query: 46 IIIAPVTRITKDILERAER--LKVISCQSAGYDHVDVEEATKRGIYVTKVSGLLSEAVAE 103
I + + I+ IL +R +K IS +S G +H+D A + GI V V+ ++VA+
Sbjct: 51 ISVGHKSEISASILVALKRGGVKYISTRSIGCNHIDTIAAKRIGITVGNVA-YSPDSVAD 109
Query: 104 FALGLLISLMRKIHYADSFIREGKWESHTFVWREFKEVETLYGK-----EVGIVGMGAIG 158
F + L++ +R S +R E H F ++++ GK VG+VG G IG
Sbjct: 110 FTMMLMLMAVRN---TKSIVRSV--EKHDF------RLDSVRGKVLSEMTVGVVGTGQIG 158
Query: 159 KAIARRLKPFGCEIYYWSRHRKEDIEREVNAKYLDLDELLEEVDIVILALPLTKETYHII 218
KA+ RL+ FGC++ +S + + Y+ DELL+ DIV L +PL +T++II
Sbjct: 159 KAVIERLRGFGCKVLAYSH------SKSIEVYYVPFDELLQNSDIVTLHVPLHTDTHYII 212
Query: 219 NEERVKKLE-GKYLVNIGRGALIDEKALVKAIKEGKLKGFATDVFEEE-----------P 266
E++++++ G +++N RG L+D ALVKA++ GKL G A DV E E P
Sbjct: 213 GHEQIQRMKKGAFIINTSRGPLVDTYALVKALENGKLGGAALDVLEGEEEFFYSDCTQRP 272
Query: 267 VKEHELFRFKW--ETVLTPHYAGLGKDVLEDMGFRAVENLL 305
+ L + + ++TPH A + L D + + N L
Sbjct: 273 IDNQFLLKLQKMPNVIITPHTAYYTEQALRDTVEKTITNCL 313
>pir||F81053 D-lactate dehydrogenase NMB1685 [imported] - Neisseria meningitidis
(group B strain MD58) >gi|7226939|gb|AAF42033.1|
(AE002519) D-lactate dehydrogenase [Neisseria
meningitidis MC58]
Length = 332
Score = 122 bits (303), Expect = 6e-27
Identities = 80/257 (31%), Positives = 132/257 (51%), Gaps = 25/257 (9%)
Query: 55 TKDILERAERL--KVISCQSAGYDHVDVEEATKRGIYVTKVSGLLSEAVAEFALGLLISL 112
++ +LE+ ++ K ++ + AG+++VD++ A + G+ V +V E+VAE +GL+++L
Sbjct: 57 SRPVLEKLAQIGVKTVALRCAGFNNVDLKAAEELGLKVVRVPAYSPESVAEHTVGLMLTL 116
Query: 113 MRKIHYADSFIREGKWESHTFVWREFKEVETLYGKEVGIVGMGAIGKAIARRLKPFGCEI 172
R+IH A R+ + E +YGK G++G G IG A R LK FG +
Sbjct: 117 NRRIHKAYQRTRDANFS------LEGLTGFNMYGKTAGVIGTGKIGIATMRILKGFGMNL 170
Query: 173 YYWSRHRKEDIEREVNAKYLDLDELLEEVDIVILALPLTKETYHIINEERVKKL-EGKYL 231
+ + E+ + KY+DLDEL DI+ L P T E ++++NE K+ +G +
Sbjct: 171 LAYDPFCNPEAEK-IGGKYVDLDELYARSDIITLHCPATPENHYMLNEAAFDKMKDGVMI 229
Query: 232 VNIGRGALIDEKALVKAIKEGKLKGFATDVFEEEPVKEHELFRFKWETVLTPHYAGLGKD 291
+N RG LID A ++A+K K+ DV+E E ELF + D
Sbjct: 230 INTSRGGLIDSAAAIEALKRRKIGALGMDVYE----NERELF-----------FEDKSND 274
Query: 292 VLEDMGFRAVENLLKVL 308
V+ D FR + + VL
Sbjct: 275 VITDDVFRRLSSCHNVL 291
>pir||T35362 probable D-lactate dehydrogenase - Streptomyces coelicolor
>gi|5123869|emb|CAB45461.1| (AL079348) putative
D-lactate dehydrogenase [Streptomyces coelicolor A3(2)]
Length = 337
Score = 122 bits (302), Expect = 8e-27
Identities = 81/217 (37%), Positives = 122/217 (55%), Gaps = 15/217 (6%)
Query: 50 PVTRITKDILERAERLKVISCQSAGYDHVDVEEATKRGIYVTKVSGLLSEAVAEFALGLL 109
PVT T L RA + IS +S GY+H+DV A GI V V+ VA++ L L+
Sbjct: 73 PVTPATLRALHRAG-VTYISTRSIGYNHIDVTYAAGVGISVENVT-YSPAGVADYTLMLM 130
Query: 110 ISLMRKIHYADSFIREGKWESHTFVWREFKEVETLYGKEVGIVGMGAIGKAIARRLKPFG 169
+ +R A S +R E H + E + E L VG++G G IG A+ RL+ FG
Sbjct: 131 LMAVRN---AKSTVRRA--ELHDYRLNEIRGKE-LRDLTVGVIGTGRIGAAVVDRLRGFG 184
Query: 170 CEIYYWSRHRKEDIEREVNAKYLDLDELLEEVDIVILALPLTKETYHIINEERVKKLE-G 228
+ + + + A Y+ LDELL DIV L +PLT +T+H++++ R+++++ G
Sbjct: 185 SRVLAYGKRPT------IAADYVSLDELLRSSDIVSLHVPLTPDTHHLLDQSRIRRMKSG 238
Query: 229 KYLVNIGRGALIDEKALVKAIKEGKLKGFATDVFEEE 265
+++N GRG LID +ALV A++ G+L G A DV E E
Sbjct: 239 AFVINTGRGPLIDTEALVPALESGRLSGAALDVIEGE 275
>pir||C71864 d-3-phosphoglycerate dehydrogenase - Helicobacter pylori (strain
J99) >gi|4155559|gb|AAD06553.1| (AE001527)
D-3-PHOSPHOGLYCERATE DEHYDROGENASE [Helicobacter pylori
J99]
Length = 524
Score = 121 bits (301), Expect = 1e-26
Identities = 82/312 (26%), Positives = 155/312 (49%), Gaps = 13/312 (4%)
Query: 4 RIGVLFKMKSKPLEELKKYTDVVLKPY---PSEEELKEIIPELDGIIIAPVTRITKDILE 60
++ + + +K ++ L+ D+VL Y P +E L+++IP +D +I +T IT D L+
Sbjct: 3 QVAICDPIHAKGIQILEAQKDIVLHDYSKCPKKELLEKLIP-MDALITRSMTPITSDFLK 61
Query: 61 RAERLKVISCQSAGYDHVDVEEATKRGIYVTKVSGLLSEAVAEFALGLLISLMRKIHYAD 120
LK I G D++D+E +++GI V + + A E + LI+ +R A+
Sbjct: 62 PLTHLKSIVRAGVGVDNIDLESCSQKGIVVMNIPTANTIAAVELTMAHLINAVRSFPCAN 121
Query: 121 SFIREGK-WESHTFVWREFKEVETLYGKEVGIVGMGAIGKAIARRLKPFGCEIYYWSRHR 179
I+ + W+ + E K K++GI+G G IG + R K F E+ + +
Sbjct: 122 DQIKHQRLWKREDWYGTELK------NKKLGIIGFGNIGSRVGIRAKAFEMEVLAYDPYI 175
Query: 180 KEDIEREVNAKYLDLDELLEEVDIVILALPLTKETYHIINEERVKKL-EGKYLVNIGRGA 238
++ Y E + + D++ + P KET ++I + ++++ +G L+N RG
Sbjct: 176 PSSKATDLGVIYTKNFEDILQCDMITIHTPKNKETINMIGAKEIERMKKGVILINCARGG 235
Query: 239 LIDEKALVKAIKEGKLKGFATDVFEEEPVKEHELFRFKWETVLTPHYAGLGKDVLEDMGF 298
L +E AL +A++ K++ DVF +EP ++L TPH + E++
Sbjct: 236 LYNEDALYEALETKKVRWLGIDVFSKEPGIHNKLLDLP-NVYATPHIGANTLESQEEISK 294
Query: 299 RAVENLLKVLRG 310
+A + +++ LRG
Sbjct: 295 QAAQGVMESLRG 306
>gb|AAC28494.1| (AF079881) D-3-phosphoglycerate dehydrogenase [Entodinium caudatum]
Length = 318
Score = 120 bits (299), Expect = 2e-26
Identities = 89/276 (32%), Positives = 141/276 (50%), Gaps = 24/276 (8%)
Query: 14 KPLEELKKYTDVVLKPYPSEEELKEIIPELDGIIIAPVTRITKDILERAERLKVISCQSA 73
K L E T +L+ Y +++EL + I + + II+ +ITK+I++ + LKVI+ A
Sbjct: 32 KKLVEKSGNTFKLLEKYKTKQELMDSIKDANAIIVRS-DKITKEIMDSSNNLKVIARAGA 90
Query: 74 GYDHVDVEEATKRGIYVTKVSGLLSEAVAEFALGLLISLMRKIHYADSFIREGKWESHTF 133
G+D++D+ A+K+GI V G + AVAE GLL+ R + S
Sbjct: 91 GFDNIDLGYASKKGIVVMNTPGQNANAVAELVFGLLVYAKRNFYDGSSGTE--------- 141
Query: 134 VWREFKEVETLYGKEVGIVGMGAIGKAIARRLKPFGCEIY-YWSRHRKEDIEREVNAKYL 192
L GK++G++ G +G+ +AR K FG EIY Y + KE +E+E
Sbjct: 142 ----------LKGKKLGLLAFGNVGRNVARIAKGFGMEIYSYDAFVPKEVLEKEGIHAVD 191
Query: 193 DLDELLEEVDIVILALPLTKETYHIINEERVKKL-EGKYLVNIGRGALIDEKALVKAIKE 251
++L + DIV L +P TKET + IN + K+ + L+N R +I+EK L+K ++E
Sbjct: 192 KQEDLFTDCDIVSLHIPATKETINSINYDLCSKMKKNAILINTSRKEVINEKELIKLMEE 251
Query: 252 GKLKGFATDVFEEEPVKEHELFRFKWETVLTPHYAG 287
K + TD+ + E L +FK TP G
Sbjct: 252 RKDIKYITDLKPDN--HEEFLNKFKGRYFATPKKMG 285
>pir||C82072 D-3-phosphoglycerate dehydrogenase VC2481 [imported] - Vibrio
cholerae (group O1 strain N16961)
>gi|9657060|gb|AAF95623.1| (AE004317)
D-3-phosphoglycerate dehydrogenase [Vibrio cholerae]
Length = 409
Score = 120 bits (299), Expect = 2e-26
Identities = 83/282 (29%), Positives = 134/282 (47%), Gaps = 19/282 (6%)
Query: 33 EEELKEIIPELDGIIIAPVTRITKDILERAERLKVISCQSAGYDHVDVEEATKRGIYVTK 92
E EL + I ++ + I + +T+ ++ AE+L I C G + VD+ A KRGI V
Sbjct: 44 EAELIKAIKDVHFVGIRSRSNLTEKVINAAEKLVAIGCFCIGTNQVDLNAAAKRGIPVFN 103
Query: 93 VSGLLSEAVAEFALGLLISLMRKIHYADSFIREGKWESHTFVWREFKEVETLY---GKEV 149
+ +VAE LG ++ L+R I ++ G W+ K + Y GK +
Sbjct: 104 APFSNTRSVAELVLGEILLLLRGIPEKNALAHRGIWK---------KSADNSYEARGKRL 154
Query: 150 GIVGMGAIGKAIARRLKPFGCEIYYWSRHRKEDIEREVNAKYLDLDELLEEVDIVILALP 209
GI+G G IG + + G +Y++ K + L ELL + D++ L +P
Sbjct: 155 GIIGYGHIGTQLGIIAENLGMHVYFYDIESKLSLGNATQVH--TLSELLNKCDVISLHVP 212
Query: 210 LTKETYHIINEERVKKLE-GKYLVNIGRGALIDEKALVKAIKEGKLKGFATDVFEEEPVK 268
T T +++ E +++ G +N RG ++D AL A++ G + G A DVF EEP
Sbjct: 213 ETAGTKNMMGAEEFARMKPGAIFINAARGTVVDIPALCNALESGHIAGAAIDVFPEEPAS 272
Query: 269 EHELFR---FKWETV-LTPHYAGLGKDVLEDMGFRAVENLLK 306
E F K++ V LTPH G ++ E++G L K
Sbjct: 273 NKEPFESPLMKFDNVILTPHVGGSTQEAQENIGIEVAGKLAK 314
>sp|P08328|SERA_ECOLI D-3-PHOSPHOGLYCERATE DEHYDROGENASE (PGDH) >gi|65956|pir||DEECPG
phosphoglycerate dehydrogenase (EC 1.1.1.95) -
Escherichia coli >gi|459755|gb|AAA24625.1| (L29397)
phosphoglycerate dehydrogenase [Escherichia coli]
>gi|882442|gb|AAA69080.1| (U28377) D-3-phosphoglycerate
dehydrogenase [Escherichia coli]
>gi|1789279|gb|AAC75950.1| (AE000374)
D-3-phosphoglycerate dehydrogenase [Escherichia coli
K12]
Length = 410
Score = 120 bits (298), Expect = 2e-26
Identities = 87/301 (28%), Positives = 143/301 (46%), Gaps = 16/301 (5%)
Query: 14 KPLEELKK--YTDVVL-KPYPSEEELKEIIPELDGIIIAPVTRITKDILERAERLKVISC 70
K LE L+ YT++ K +E+LKE I + I + T +T+D++ AE+L I C
Sbjct: 22 KALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVINAAEKLVAIGC 81
Query: 71 QSAGYDHVDVEEATKRGIYVTKVSGLLSEAVAEFALGLLISLMRKIHYADSFIREGKWES 130
G + VD++ A KRGI V + +VAE +G L+ L+R + A++ G W
Sbjct: 82 FCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEANAKAHRGVWNK 141
Query: 131 HTFVWREFKEVETLYGKEVGIVGMGAIGKAIARRLKPFGCEIYYWSRHRKEDIEREVNAK 190
E + GK++GI+G G IG + + G +Y++ K + +
Sbjct: 142 LAAGSFEAR------GKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGNATQVQ 195
Query: 191 YLDLDELLEEVDIVILALPLTKETYHIINEERVKKLE-GKYLVNIGRGALIDEKALVKAI 249
+ L +LL D+V L +P T +++ + + ++ G L+N RG ++D AL A+
Sbjct: 196 H--LSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALCDAL 253
Query: 250 KEGKLKGFATDVFEEEPVKEHELFRFKW----ETVLTPHYAGLGKDVLEDMGFRAVENLL 305
L G A DVF EP + F +LTPH G ++ E++G L+
Sbjct: 254 ASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVAGKLI 313
Query: 306 K 306
K
Sbjct: 314 K 314
>pdb|1PSD|A Chain A, D-3-Phosphoglycerate Dehydrogenase (Phosphoglycerate
Dehydrogenase) (E.C.1.1.1.95) >gi|1127237|pdb|1PSD|B
Chain B, D-3-Phosphoglycerate Dehydrogenase
(Phosphoglycerate Dehydrogenase) (E.C.1.1.1.95)
Length = 409
Score = 120 bits (298), Expect = 2e-26
Identities = 87/301 (28%), Positives = 143/301 (46%), Gaps = 16/301 (5%)
Query: 14 KPLEELKK--YTDVVL-KPYPSEEELKEIIPELDGIIIAPVTRITKDILERAERLKVISC 70
K LE L+ YT++ K +E+LKE I + I + T +T+D++ AE+L I C
Sbjct: 21 KALESLRAAGYTNIEFHKGALDDEQLKESIRDAHFIGLRSRTHLTEDVINAAEKLVAIGC 80
Query: 71 QSAGYDHVDVEEATKRGIYVTKVSGLLSEAVAEFALGLLISLMRKIHYADSFIREGKWES 130
G + VD++ A KRGI V + +VAE +G L+ L+R + A++ G W
Sbjct: 81 FCIGTNQVDLDAAAKRGIPVFNAPFSNTRSVAELVIGELLLLLRGVPEANAKAHRGVWNK 140
Query: 131 HTFVWREFKEVETLYGKEVGIVGMGAIGKAIARRLKPFGCEIYYWSRHRKEDIEREVNAK 190
E + GK++GI+G G IG + + G +Y++ K + +
Sbjct: 141 LAAGSFEAR------GKKLGIIGYGHIGTQLGILAESLGMYVYFYDIENKLPLGNATQVQ 194
Query: 191 YLDLDELLEEVDIVILALPLTKETYHIINEERVKKLE-GKYLVNIGRGALIDEKALVKAI 249
+ L +LL D+V L +P T +++ + + ++ G L+N RG ++D AL A+
Sbjct: 195 H--LSDLLNMSDVVSLHVPENPSTKNMMGAKEISLMKPGSLLINASRGTVVDIPALCDAL 252
Query: 250 KEGKLKGFATDVFEEEPVKEHELFRFKW----ETVLTPHYAGLGKDVLEDMGFRAVENLL 305
L G A DVF EP + F +LTPH G ++ E++G L+
Sbjct: 253 ASKHLAGAAIDVFPTEPATNSDPFTSPLCEFDNVLLTPHIGGSTQEAQENIGLEVAGKLI 312
Query: 306 K 306
K
Sbjct: 313 K 313
>gi|6320925 3-phosphoglycerate dehydrogenase; Ser3p [Saccharomyces cerevisiae]
>gi|731484|sp|P40054|SERA_YEAST D-3-PHOSPHOGLYCERATE
DEHYDROGENASE 1 (PGDH) >gi|1077676|pir||S50584 probable
phosphoglycerate dehydrogenase (EC 1.1.1.95) YER081w -
yeast (Saccharomyces cerevisiae)
>gi|603319|gb|AAB64636.1| (U18839) Yer081wp
[Saccharomyces cerevisiae]
Length = 469
Score = 120 bits (297), Expect = 3e-26
Identities = 92/292 (31%), Positives = 141/292 (47%), Gaps = 27/292 (9%)
Query: 33 EEELKEIIPELDGIIIAPVTRITKDILERAERLKVISCQSAGYDHVDVEEATKRGIYVTK 92
EEEL E I ++ I I TR+T ++L+ A+ L I C G + VD++ AT RGI V
Sbjct: 91 EEELIEKIKDVHAIGIRSKTRLTSNVLQHAKNLVCIGCFCIGTNQVDLDYATSRGIAVFN 150
Query: 93 VSGLLSEAVAEFALGLLISLMRKIHYADSFIREGKWESHTFVWREF-KEVETLYGKEVGI 151
S +VAE + +ISL R++ D I E HT W + + GK +GI
Sbjct: 151 SPFSNSRSVAELVIAEIISLARQL--GDRSI-----ELHTGTWNKVAARCWEVRGKTLGI 203
Query: 152 VGMGAIGKAIARRLKPFGCEIYYWS--RHRKEDIEREVNAKYLDLDELLEEVDIVILALP 209
+G G IG ++ + G + Y+ R+V+ LDELL + D V L +P
Sbjct: 204 IGYGHIGSQLSVLAEAMGLHVLYYDIVTIMALGTARQVST----LDELLNKSDFVTLHVP 259
Query: 210 LTKETYHIINEERVKKL-EGKYLVNIGRGALIDEKALVKAIKEGKLKGFATDVFEEEPVK 268
T ET +++ + + +G Y++N RG ++D +L++A+K K+ G A DV+ EP K
Sbjct: 260 ATPETEKMLSAPQFAAMKDGAYVINASRGTVVDIPSLIQAVKANKIAGAALDVYPHEPAK 319
Query: 269 ------EHELFRFKWETV------LTPHYAGLGKDVLEDMGFRAVENLLKVL 308
EL + E V LTPH G ++ +G L K +
Sbjct: 320 NGEGSFNDELNSWTSELVSLPNIILTPHIGGSTEEAQSSIGIEVATALSKYI 371
>pir||E64569 phosphoglycerate dehydrogenase - Helicobacter pylori (strain 26695)
>gi|2313497|gb|AAD07461.1| (AE000555) phosphoglycerate
dehydrogenase (serA) [Helicobacter pylori 26695]
Length = 524
Score = 118 bits (294), Expect = 7e-26
Identities = 81/312 (25%), Positives = 154/312 (48%), Gaps = 13/312 (4%)
Query: 4 RIGVLFKMKSKPLEELKKYTDVVLKPY---PSEEELKEIIPELDGIIIAPVTRITKDILE 60
++ + + +K ++ L+ D+VL Y P +E L+++ P +D +I +T IT D L+
Sbjct: 3 QVAICDPIHAKGIQILEAQKDIVLHDYSKCPKKELLEKLTP-MDALITRSMTPITSDFLK 61
Query: 61 RAERLKVISCQSAGYDHVDVEEATKRGIYVTKVSGLLSEAVAEFALGLLISLMRKIHYAD 120
LK I G D++D+E +++GI V + + A E + LI+ +R A+
Sbjct: 62 PLTHLKSIVRAGVGVDNIDLESCSQKGIVVMNIPTANTIAAVELTMAHLINAVRSFPCAN 121
Query: 121 SFIREGK-WESHTFVWREFKEVETLYGKEVGIVGMGAIGKAIARRLKPFGCEIYYWSRHR 179
I+ + W+ + E K K++GI+G G IG + R K F E+ + +
Sbjct: 122 DQIKHQRLWKREDWYGTELK------NKKLGIIGFGNIGSRVGIRAKAFEMEVLAYDPYI 175
Query: 180 KEDIEREVNAKYLDLDELLEEVDIVILALPLTKETYHIINEERVKKL-EGKYLVNIGRGA 238
++ Y E + + D++ + P KET ++I + ++++ +G L+N RG
Sbjct: 176 PSSKATDLGVIYTKNFEDILQCDMITIHTPKNKETINMIGAKEIERMKKGVILLNCARGG 235
Query: 239 LIDEKALVKAIKEGKLKGFATDVFEEEPVKEHELFRFKWETVLTPHYAGLGKDVLEDMGF 298
L +E AL +A++ K++ DVF +EP ++L TPH + E++
Sbjct: 236 LYNEDALYEALETKKVRWLGIDVFSKEPGIHNKLLDLP-NVYATPHIGANTLESQEEISK 294
Query: 299 RAVENLLKVLRG 310
+A + +++ LRG
Sbjct: 295 QAAQGVMESLRG 306
>pir||F82068 2-hydroxyacid dehydrogenase family protein VC2504 [imported] -
Vibrio cholerae (group O1 strain N16961)
>gi|9657086|gb|AAF95646.1| (AE004320) 2-hydroxyacid
dehydrogenase family protein [Vibrio cholerae]
Length = 325
Score = 118 bits (293), Expect = 9e-26
Identities = 78/276 (28%), Positives = 138/276 (49%), Gaps = 8/276 (2%)
Query: 46 IIIAPVTRITKDILERAERLKVISCQSAGYDHVDVEEATKRGIYVTKVSGLLSEAVAEFA 105
I+I +T+++L + +LK+I+ + G ++VD+ I V V G + +V E
Sbjct: 54 IVITNKVVLTREMLIQLPKLKLIAISATGTNNVDLPACRDLNIAVCNVQGYATRSVPEHV 113
Query: 106 LGLLISLMRKIHYADSFIREGKWESHTFVWREFKEVETLYGKEVGIVGMGAIGKAIARRL 165
+ ++ +L R + + I G+W+ H + + G +GI+G GA+G+A A
Sbjct: 114 VAMMFALRRNLIGYHNDIAAGEWQRHKQFCFFTHPIGDIAGSTMGIIGSGALGQATANLA 173
Query: 166 KPFGCEIYYWSRHRKEDIEREVNAKYLDLDELLEEVDIVILALPLTKETYHIINEERVKK 225
+ G + RK +E Y +++L + D++ L PLT ET +II+E + +
Sbjct: 174 RALGMHVLL--AERKGQVE--CRDGYTSFEQVLAQSDVLSLHCPLTDETRNIISEAELAQ 229
Query: 226 LE-GKYLVNIGRGALIDEKALVKAIKEGKLKGFATDVFEEEPV-KEHELF--RFKWETVL 281
+ L+N GRG L+DE+ALV A+K ++ G DVF EP ++ L R +L
Sbjct: 230 MNPNALLINTGRGGLVDEQALVDALKRRQIAGAGVDVFSAEPADMDNPLIANRDLPNLLL 289
Query: 282 TPHYAGLGKDVLEDMGFRAVENLLKVLRGEIPEDLV 317
TPH A ++ + ++N+ +RGE +V
Sbjct: 290 TPHVAWGSDSSIQQLATILIDNISAFMRGEAKNRVV 325
>gi|6322116 3-phosphoglycerate dehydrogenase; Ser33p [Saccharomyces cerevisiae]
>gi|731830|sp|P40510|SE33_YEAST D-3-PHOSPHOGLYCERATE
DEHYDROGENASE 2 (PGDH) >gi|626300|pir||S48370 probable
phosphoglycerate dehydrogenase (EC 1.1.1.95) YIL074c -
yeast (Saccharomyces cerevisiae)
>gi|556873|emb|CAA86096.1| (Z37997) orf, len: 469, CAI:
0.23, similar to SERA_ECOLI P08328 D-3-PHOSPHOGLYCERATE
DEHYDROGENASE [Saccharomyces cerevisiae]
Length = 469
Score = 118 bits (292), Expect = 1e-25
Identities = 94/312 (30%), Positives = 147/312 (46%), Gaps = 27/312 (8%)
Query: 33 EEELKEIIPELDGIIIAPVTRITKDILERAERLKVISCQSAGYDHVDVEEATKRGIYVTK 92
E+EL E I ++ I I TR+T+ IL+ A L I C G + VD++ A +GI V
Sbjct: 91 EDELIEKIKDVHAIGIRSKTRLTEKILQHARNLVCIGCFCIGTNQVDLKYAASKGIAVFN 150
Query: 93 VSGLLSEAVAEFALGLLISLMRKIHYADSFIREGKWESHTFVWREF-KEVETLYGKEVGI 151
S +VAE +G +ISL R++ D I E HT W + + GK +GI
Sbjct: 151 SPFSNSRSVAELVIGEIISLARQL--GDRSI-----ELHTGTWNKVAARCWEVRGKTLGI 203
Query: 152 VGMGAIGKAIARRLKPFGCEIYYWS--RHRKEDIEREVNAKYLDLDELLEEVDIVILALP 209
+G G IG ++ + G + Y+ R+V+ LDELL + D V L +P
Sbjct: 204 IGYGHIGSQLSVLAEAMGLHVLYYDIVTIMALGTARQVST----LDELLNKSDFVTLHVP 259
Query: 210 LTKETYHIINEERVKKL-EGKYLVNIGRGALIDEKALVKAIKEGKLKGFATDVFEEEPVK 268
T ET +++ + + +G Y++N RG ++D +L++A+K K+ G A DV+ EP K
Sbjct: 260 ATPETEKMLSAPQFAAMKDGAYVINASRGTVVDIPSLIQAVKANKIAGAALDVYPHEPAK 319
Query: 269 ------EHELFRFKWETV------LTPHYAGLGKDVLEDMGFRAVENLLKVLRGEIPEDL 316
EL + E V LTPH G ++ +G L K +
Sbjct: 320 NGEGSFNDELNSWTSELVSLPNIILTPHIGGSTEEAQSSIGIEVATALSKYINEGNSVGS 379
Query: 317 VNKEVLKVRPID 328
VN + ++ +D
Sbjct: 380 VNFPEVSLKSLD 391
>gb|AAD51059.1|AF175293_4 (AF175293) D-lactate dehydrogenase [Enterococcus faecium]
Length = 323
Score = 118 bits (292), Expect = 1e-25
Identities = 84/259 (32%), Positives = 140/259 (53%), Gaps = 27/259 (10%)
Query: 65 LKVISCQSAGYDHVDVEEATKRGIYVTKVSGLLSEAVAEFALGLLISLMRKIHYADSFIR 124
+K IS +S G++H+D++ A G+ V V +VA++ + L++ LMR S +R
Sbjct: 73 VKYISTRSIGFNHIDIQAAGLLGMVVGTVE-YSPGSVADYTVMLMLMLMRG---TKSILR 128
Query: 125 EGKWESHTFVWREFKEVETLYGKEVGIVGMGAIGKAIARRLKPFGCEIYYWSRHRKEDIE 184
E + +++ KE+ + VG++G G IG+A+ RL+ FGC++ + R++K
Sbjct: 129 ETQRQNYCLNDLRGKELRDM---TVGVLGTGRIGQAVMERLEGFGCKVLAYDRNQK---- 181
Query: 185 REVNAKYLDLDELLEEVDIVILALPLTKETYHIINEERVKKLEGK-YLVNIGRGALIDEK 243
A Y+ ELL++ DIV L +PL ++T H+I E ++ ++ + L+N GRGAL+D
Sbjct: 182 --AGADYVSFHELLKKSDIVTLHIPLAEDTRHMIGYEELEMMKQEALLINTGRGALVDTA 239
Query: 244 ALVKAIKEGKLKGFATDVFE-EEPVKEHELFRFKWE------------TVLTPHYAGLGK 290
ALV+A+K K+ G A DV E EE + H+ + + E ++TPH A +
Sbjct: 240 ALVEALKGQKIGGAALDVLEGEEGIFYHDCTQRRIEHPFLSVLQGMPNVIVTPHTAYHTE 299
Query: 291 DVLEDMGFRAVENLLKVLR 309
VL D + N L R
Sbjct: 300 RVLVDTVRNTIRNCLNFER 318
>gb|AAK41187.1| D-3-phosphoglycerate dehydrogenase (serA-1) [Sulfolobus
solfataricus]
Length = 326
Score = 117 bits (291), Expect = 2e-25
Identities = 80/287 (27%), Positives = 148/287 (50%), Gaps = 15/287 (5%)
Query: 28 KPYPSEEELKEIIPELDGIIIAPVTRITKDILERAERLKVISCQSAGYDHVDVEEATKRG 87
KP + EEL +II + +I+ T++ K+I+ LK+I+ G D++D EEA+KR
Sbjct: 44 KPEITREELLKIIDQYQVLIVRSRTKVDKEIIRYGVNLKIIARAGIGLDNIDTEEASKRN 103
Query: 88 IYVTKVSGLLSEAVAEFALGLLISLMRKIHYADSFIREGKWESHTFVWREFKEVETLYGK 147
I + G +++ AE +GLLI+ RK++ + + + G ++++ + +E L GK
Sbjct: 104 IKIVYAPGASTDSAAELTIGLLIAAARKLYDSMNMAKGG-------IFKKIEGIE-LAGK 155
Query: 148 EVGIVGMGAIGKAIARRLKPFGCEIYYWSRHRKEDIEREVNAKYLD-LDELLEEVDIVIL 206
+GIVG G IG +A+ K + + ++ V + + L+ELL+ D++
Sbjct: 156 TIGIVGFGRIGTKVAKVCKALDMNVIAYDVINIKEKANIVGVRVAESLEELLKNSDVITF 215
Query: 207 ALPLTKETYHIINEERVKKL-EGKYLVNIGRGALIDEKALVKAIKEGKLKGFATDVFEEE 265
+ + K+ I+N++ + + ++N R +ID KAL++ I + L +ATDV E
Sbjct: 216 HVTVGKDAKPILNKDTFNYIKDNAIIINTSRAVVIDGKALLEYIDKKHLT-YATDVLWNE 274
Query: 266 PVKEH---ELFRFKWETVLTPHYAGLGKDVLEDMGFRAVENLLKVLR 309
P KE +L R + ++T H K+ + +NL+ L+
Sbjct: 275 PPKEDWEIKLLRHE-RVIVTTHIGAQTKEAQHRVAVVTTDNLITALK 320
>pir||S45534 phosphoglycerate dehydrogenase (EC 1.1.1.95) - Bacillus subtilis
(fragment) >gi|410116|gb|AAA67502.1| (L09228)
phosphoglycerate dehydrogenase [Bacillus subtilis]
Length = 419
Score = 117 bits (291), Expect = 2e-25
Identities = 72/227 (31%), Positives = 119/227 (51%), Gaps = 14/227 (6%)
Query: 111 SLMRKIHYADSFIREGKWESHTFVWREFKEVETLYGKEVGIVGMGAIGKAIARRLKPFGC 170
SLMR I A+ ++ +W +V E LYGK +GIVG+G IG IA+R FG
Sbjct: 3 SLMRHIPQANISVKSREWNRTAYVGSE------LYGKTLGIVGLGRIGSEIAQRRGAFGM 56
Query: 171 EIYYWSRHRKEDIEREVNAKYLDLDELLEEVDIVILALPLTKETYHIINEERVKKL-EGK 229
++ + E+ +++ +E+LE DI+ + PLTKET ++N+E + K +G
Sbjct: 57 TVHVFDPFLTEERAKKIGVNSRTFEEVLESADIITVHTPLTKETKGLLNKETIAKTKKGV 116
Query: 230 YLVNIGRGALIDEKALVKAIKEGKLKGFATDVFEEEPVKEHELFRFKWETVLTPHYAGLG 289
L+N RG +IDE AL++A++ G + G A DVFE EP +++L + TPH
Sbjct: 117 RLINCARGGIIDEAALLEALENGHVAGAALDVFEVEPPVDNKLVDHPL-VIATPHLGAST 175
Query: 290 KDVLEDMGFRAVENLLKVLRGEIPEDLVN------KEVLKVRPIDEV 330
K+ ++ + E +L+ +G +N E K++P ++
Sbjct: 176 KEAQLNVAAQVSEEVLQFAKGLPVMSAINLPAMTKDEFAKIKPYHQI 222
>pir||C83607 D-3-phosphoglycerate dehydrogenase PA0316 [imported] - Pseudomonas
aeruginosa (strain PAO1)
>gi|9946162|gb|AAG03705.1|AE004469_10 (AE004469)
D-3-phosphoglycerate dehydrogenase [Pseudomonas
aeruginosa]
Length = 409
Score = 115 bits (286), Expect = 6e-25
Identities = 89/291 (30%), Positives = 140/291 (47%), Gaps = 14/291 (4%)
Query: 22 YTDV-VLKPYPSEEELKEIIPELDGIIIAPVTRITKDILERAERLKVISCQSAGYDHVDV 80
YT++ LK S +ELKE I + I I T++T+++ + A++L + C G + VD+
Sbjct: 32 YTNIEYLKTALSGDELKERIADAHFIGIRSRTQLTEEVFDCAKKLIAVGCFCIGTNQVDL 91
Query: 81 EEATKRGIYVTKVSGLLSEAVAEFALGLLISLMRKIHYADSFIREGKWESHTFVWREFKE 140
A +RGI V + +VAE L I L+R I ++ G W E +
Sbjct: 92 NAARERGIAVFNAPYSNTRSVAELVLAEAILLLRGIPEKNASCHRGGWIKSAANSFEIR- 150
Query: 141 VETLYGKEVGIVGMGAIGKAIARRLKPFGCEIYYWSRHRKEDIEREVNAKYLDLDELLEE 200
GK++GIVG G+IG ++ + G +++++ K + V L ELL
Sbjct: 151 -----GKKLGIVGYGSIGTQLSVLAEALGMQVFFYDTVTKLPLGNAVQIG--SLHELLGM 203
Query: 201 VDIVILALPLTKETYHIINEERVKKL-EGKYLVNIGRGALIDEKALVKAIKEGKLKGFAT 259
DIV L +P T +I E+ ++ + +G L+N RG +++ L AIK+ L G A
Sbjct: 204 SDIVSLHVPELPSTQWMIGEKEIRAMKKGGILINAARGTVVELDHLAAAIKDEHLIGAAI 263
Query: 260 DVFEEEPVKEHELF----RFKWETVLTPHYAGLGKDVLEDMGFRAVENLLK 306
DVF EP E F R +LTPH G + ++G E L+K
Sbjct: 264 DVFPVEPKSNDEEFASPLRGLDRVILTPHIGGSTAEAQANIGLEVAEKLVK 314
>gb|AAC49766.1| (AF004096) NAD-dependent formate dehydrogenase [Candida boidinii]
>gi|5824352|emb|CAB54834.1| (AJ245934) formate
dehydrogenase [Candida boidinii]
Length = 364
Score = 115 bits (285), Expect = 8e-25
Identities = 82/270 (30%), Positives = 140/270 (51%), Gaps = 17/270 (6%)
Query: 35 ELKEIIPELDGIIIAPV--TRITKDILERAERLKVISCQSAGYDHVDVEEATKRG--IYV 90
EL + IP+ D II P ITK+ L++A+ LK++ G DH+D++ + G I V
Sbjct: 53 ELDKHIPDADIIITTPFHPAYITKERLDKAKNLKLVVVAGVGSDHIDLDYINQTGKKISV 112
Query: 91 TKVSGLLSEAVAEFALGLLISLMRKIHYADSFIREGKWESHTFVWREFKEVETLYGKEVG 150
+V+G +VAE + ++ L+R A I WE K+ + GK +
Sbjct: 113 LEVTGSNVVSVAEHVVMTMLVLVRNFVPAHEQIINHDWEVAAIA----KDAYDIEGKTIA 168
Query: 151 IVGMGAIGKAIARRLKPFGCE--IYYWSRHRKEDIEREVNAKYLD-LDELLEEVDIVILA 207
+G G IG + RL PF + +YY + ++ E +V A+ ++ ++EL+ + DIV +
Sbjct: 169 TIGAGRIGYRVLERLLPFNPKELLYYDYQALPKEAEEKVGARRVENIEELVAQADIVTVN 228
Query: 208 LPLTKETYHIINEERVKKLE-GKYLVNIGRGALIDEKALVKAIKEGKLKGFATDVFEEEP 266
PL T +IN+E + K + G +LVN RGA+ + + A++ G+L+G+ DV+ +P
Sbjct: 229 APLHAGTKGLINKELLSKFKKGAWLVNTARGAICVAEDVAAALESGQLRGYGGDVWFPQP 288
Query: 267 VKEHELFR-----FKWETVLTPHYAGLGKD 291
+ +R + +TPHY+G D
Sbjct: 289 APKDHPWRDMRNKYGAGNAMTPHYSGTTLD 318
>emb|CAA09466.2| (AJ011046) formate dehydrogenase [Candida boidinii]
Length = 364
Score = 115 bits (285), Expect = 8e-25
Identities = 81/269 (30%), Positives = 140/269 (51%), Gaps = 17/269 (6%)
Query: 36 LKEIIPELDGIIIAPV--TRITKDILERAERLKVISCQSAGYDHVDVEEATKRG--IYVT 91
L + IP+ D II P ITK+ +++A++LK++ G DH+D++ + G I V
Sbjct: 54 LDQHIPDADIIITTPFHPAYITKERIDKAKKLKLVVVAGVGSDHIDLDYINQTGKKISVL 113
Query: 92 KVSGLLSEAVAEFALGLLISLMRKIHYADSFIREGKWESHTFVWREFKEVETLYGKEVGI 151
+V+G +VAE + ++ L+R A I WE K+ + GK +
Sbjct: 114 EVTGSNVVSVAEHVVMTMLVLVRNFVPAHEQIINHDWEVAAIA----KDAYDIEGKTIAT 169
Query: 152 VGMGAIGKAIARRLKPFGCE--IYYWSRHRKEDIEREVNAKYLD-LDELLEEVDIVILAL 208
+G G IG + RL PF + +YY + +D E +V A+ ++ ++EL+ + DIV +
Sbjct: 170 IGAGRIGYRVLERLVPFNPKELLYYDYQALPKDAEEKVGARRVENIEELVAQADIVTVNA 229
Query: 209 PLTKETYHIINEERVKKLE-GKYLVNIGRGALIDEKALVKAIKEGKLKGFATDVFEEEPV 267
PL T +IN+E + K + G +LVN RGA+ + + A++ G+L+G+ DV+ +P
Sbjct: 230 PLHAGTKGLINKELLSKFKKGAWLVNTARGAICVAEDVAAALESGQLRGYGGDVWFPQPA 289
Query: 268 KEHELFR-----FKWETVLTPHYAGLGKD 291
+ +R + +TPHY+G D
Sbjct: 290 PKDHPWRDMRNKYGAGNAMTPHYSGTTLD 318
>sp|P26298|LDHD_LACPE D-LACTATE DEHYDROGENASE (D-LDH) >gi|98677|pir||A40885 D-lactate
dehydrogenase (EC 1.1.1.28) - Lactobacillus pentosus
(ATCC 8041) >gi|216746|dbj|BAA14352.1| (D90339)
D-lactate dehydrogenase [Lactobacillus plantarum]
Length = 332
Score = 115 bits (284), Expect = 1e-24
Identities = 77/255 (30%), Positives = 132/255 (51%), Gaps = 18/255 (7%)
Query: 19 LKKYTDVVLKPYPS--EEELKEIIPELDGIIIAPVTRITKDILERA--ERLKVISCQSAG 74
+K+ DV +K P E+ ++ DG + T ++L + E +K IS ++ G
Sbjct: 20 MKENPDVEVKLVPELLTEDNVDLAKGFDGADVYQQKDYTAEVLNKLADEGVKNISLRNVG 79
Query: 75 YDHVDVEEATKRGIYVTKVSGLLSEAVAEFALGLLISLMRKIHYADSFIREGKWESHTFV 134
D++DV RG+ ++ V A+AE ++ L+ L+R+ + K F
Sbjct: 80 VDNLDVPTVKARGLNISNVPAYSPNAIAELSVTQLMQLLRQTPMFNK-----KLAKQDFR 134
Query: 135 WRE--FKEVETLYGKEVGIVGMGAIGKAIARRLKPFGCEIYYWSRHRKEDIEREVNAKYL 192
W KE+ T+ VG++G G IG+A K FG ++ + +R ++E+E Y+
Sbjct: 135 WAPDIAKELNTM---TVGVIGTGRIGRAAIDIFKGFGAKVIGYDVYRNAELEKE--GMYV 189
Query: 193 D-LDELLEEVDIVILALPLTKETYHIINEERVKKL-EGKYLVNIGRGALIDEKALVKAIK 250
D LDEL + D++ L +P K+ YH++N + K+ +G Y++N RG LID + L+KA+
Sbjct: 190 DTLDELYAQADVITLHVPALKDNYHMLNADAFSKMKDGAYILNFARGTLIDSEDLIKALD 249
Query: 251 EGKLKGFATDVFEEE 265
GK+ G A +E E
Sbjct: 250 SGKVAGAALVTYEYE 264
>gb|AAG21503.1|AC067754_18 (AC067754) phosphoglycerate dehydrogenase, putative; 33424-31403
[Arabidopsis thaliana]
Length = 344
Score = 115 bits (284), Expect = 1e-24
Identities = 86/285 (30%), Positives = 144/285 (50%), Gaps = 28/285 (9%)
Query: 22 YTDVVLKPYP-------SEEELKEIIPELDGIIIAPVTRITKDILERAERLKVISCQSAG 74
+T L+PYP ++ E+I I +A ++ +++ RA +K+I G
Sbjct: 38 FTREYLQPYPFIKVDVVHYRDVPEVIKNYH-ICVAMTMQMDSNVISRASNIKLIMQYGVG 96
Query: 75 YDHVDVEEATKRGIYVTKVSGL---LSEAVAEFALGLLISLMRKIHYADSFIREGKWESH 131
D VD++ ATK GI V ++ + + +E A+ L++ L++K + +R
Sbjct: 97 LDGVDIDAATKHGIKVARIPSEGTGNAASCSEMAIYLMLGLLKKQNEMQISLRNRLLGEP 156
Query: 132 TFVWREFKEVETLYGKEVGIVGMGAIGKAIARRLKPFGCEIY----YWSRHRKEDIEREV 187
T +TL GK V I+G G IG +A+RLKPFG + +W + R V
Sbjct: 157 TG--------DTLLGKTVFILGYGNIGIELAKRLKPFGSRVIATKRFWPASIVDSDSRLV 208
Query: 188 NAK--YLDLDELLEEVDIVILALPLTKETYHIINEERVKKLE-GKYLVNIGRGALIDEKA 244
+ K + D+ + DIV++ L L KET I+N+E + ++ G LVNI RG LI+ ++
Sbjct: 209 DEKGSHEDIYTFAGKADIVVVCLRLNKETAEIVNKEFICSMKKGALLVNIARGGLINYES 268
Query: 245 LVKAIKEGKLKGFATDVFEEEPVKEHE-LFRFKWETVLTPHYAGL 288
+ ++ G L G DV EP ++ + +FK ++TPH AG+
Sbjct: 269 AFQNLESGHLGGLGIDVAWSEPFDPNDPILKFK-NVIITPHVAGV 312
>pir||JC4252 formate dehydrogenase (EC 1.2.1.2) - yeast (Candida methylica)
>gi|1181204|emb|CAA57036.1| (X81129) NAD-dependent
formate dehydrogenase [Candida methylica]
Length = 364
Score = 114 bits (282), Expect = 2e-24
Identities = 82/270 (30%), Positives = 139/270 (51%), Gaps = 17/270 (6%)
Query: 35 ELKEIIPELDGIIIAPV--TRITKDILERAERLKVISCQSAGYDHVDVEEATKRG--IYV 90
EL + IP+ D II P ITK+ L++A+ LK + G DH+D++ + G I V
Sbjct: 53 ELDKHIPDADIIITTPFHPAYITKERLDKAKNLKSVVVAGVGSDHIDLDYINQTGKKISV 112
Query: 91 TKVSGLLSEAVAEFALGLLISLMRKIHYADSFIREGKWESHTFVWREFKEVETLYGKEVG 150
+V+G +VAE + ++ L+R A I WE K+ + GK +
Sbjct: 113 LEVTGSNVVSVAEHVVMTMLVLVRNFVPAHEQIINHDWEVAAIA----KDAYDIEGKTIA 168
Query: 151 IVGMGAIGKAIARRLKPFGCE--IYYWSRHRKEDIEREVNAKYLD-LDELLEEVDIVILA 207
+G G IG + RL PF + +YY + ++ E +V A+ ++ ++EL+ + DIV +
Sbjct: 169 TIGAGRIGYRVLERLLPFNPKELLYYDYQALPKEAEEKVGARRVENIEELVAQADIVTVN 228
Query: 208 LPLTKETYHIINEERVKKLE-GKYLVNIGRGALIDEKALVKAIKEGKLKGFATDVFEEEP 266
PL T +IN+E + K + G +LVN RGA+ + + A++ G+L+G+ DV+ +P
Sbjct: 229 APLHAGTKGLINKELLSKFKKGAWLVNTARGAICVAEDVAAALESGQLRGYGGDVWFPQP 288
Query: 267 VKEHELFR-----FKWETVLTPHYAGLGKD 291
+ +R + +TPHY+G D
Sbjct: 289 APKDHPWRDMRNKYGAGNAMTPHYSGTTLD 318
>dbj|BAB04668.1| (AP001510) D-3-phosphoglycerate dehydrogenase [Bacillus halodurans]
Length = 316
Score = 113 bits (281), Expect = 2e-24
Identities = 79/275 (28%), Positives = 136/275 (48%), Gaps = 9/275 (3%)
Query: 17 EELKKYTDVVLKPYPSEEELKEIIPELDGIIIAPVTRITKDILERAERLKVISCQSAGYD 76
E L Y +V + E + + E D ++I +T++ L+ A++LK I SAG +
Sbjct: 16 ELLDDYPNVHFHFFERMEIVGSALEEAD-VLITYGEDVTEEHLQAAKKLKWIMVISAGVE 74
Query: 77 HVDVEEATKRGIYVTKVSGLLSEAVAEFALGLLISLMRKIHYADSFIREGKWESHTFVWR 136
+ + ++GI VT G+ + +AE+ L +++ + R S +E W+ R
Sbjct: 75 QLPFQAIKEKGIIVTNAKGIHAIPMAEYTLSMMLQVARNAKRLISLEQEQTWD------R 128
Query: 137 EFKEVETLYGKEVGIVGMGAIGKAIARRLKPFGCEIYYWSRHRKEDIEREVNAKYLDLDE 196
+E L G+ VG++G GAIG+ IAR K F + + + + +D
Sbjct: 129 RVPMIE-LNGQTVGVLGAGAIGQEIARLAKAFRMKTIGMNSTGRTVSSFDQIVPPASVDT 187
Query: 197 LLEEVDIVILALPLTKETYHIINEERVKKLE-GKYLVNIGRGALIDEKALVKAIKEGKLK 255
LL+ D V+ LP TK T + ER + ++ +NIGRG + + L+KA++E +
Sbjct: 188 LLKNSDFVVSVLPFTKRTEGFMTYERFQLMKPSAVFINIGRGKTVKQTELLKALEEKAIS 247
Query: 256 GFATDVFEEEPVKEHELFRFKWETVLTPHYAGLGK 290
DVFEEEP++E+ F +TPH +G+ +
Sbjct: 248 HAVLDVFEEEPLEENHPFWTMDSVTVTPHLSGISR 282
>dbj|BAA14985.1| (D90775) D-lactate dehydrogenase (EC 1.1.1.28) (D-LDH).
[Escherichia coli]
Length = 229
Score = 112 bits (278), Expect = 5e-24
Identities = 76/234 (32%), Positives = 120/234 (50%), Gaps = 22/234 (9%)
Query: 99 EAVAEFALGLLISLMRKIHYADSFIREGKWESHTFVWREFKEVETLYGKEVGIVGMGAIG 158
EAVAE A+G++++L R+IH A R+ + T+YGK G++G G IG
Sbjct: 3 EAVAEHAIGMMMTLNRRIHRAYQRTRDANFSLEGLTGF------TMYGKTAGVIGTGKIG 56
Query: 159 KAIARRLKPFGCEIYYWSRHRKEDIEREVNAKYLDLDELLEEVDIVILALPLTKETYHII 218
A+ R LK FG + + + E+ +Y+DL L E D++ L PLT E YH++
Sbjct: 57 VAMLRILKGFGMRLLAFDPYPSA-AALELGVEYVDLPTLFSESDVISLHCPLTPENYHLL 115
Query: 219 NEERVKKLE-GKYLVNIGRGALIDEKALVKAIKEGKLKGFATDVFEEE----------PV 267
NE ++++ G +VN RGALID +A ++A+K K+ DV+E E V
Sbjct: 116 NEAAFEQMKNGVMIVNTSRGALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDV 175
Query: 268 KEHELFR---FKWETVLTPHYAGLGKDVLEDMGFRAVENLLKVLRGE-IPEDLV 317
+ ++FR + T H A L + L + ++NL + +GE P +LV
Sbjct: 176 IQDDVFRRLSACHNVLFTGHQAFLTAEALTSISQTTLQNLSNLEKGETCPNELV 229
>sp|P30901|LDHD_LACHE D-LACTATE DEHYDROGENASE (D-LDH) >gi|478777|pir||S29296 D-lactate
dehydrogenase (EC 1.1.1.28) - Lactobacillus helveticus
>gi|1431687|pdb|2DLD|A Chain A, D-Lactate Dehydrogenase
Complexed With Nadh And Oxamate >gi|1431688|pdb|2DLD|B
Chain B, D-Lactate Dehydrogenase Complexed With Nadh And
Oxamate >gi|43997|emb|CAA47255.1| (X66723) D-lactate
dehydrogenase [Lactobacillus helveticus]
>gi|520453|gb|AAA20464.1| (U07604) D-lactate
dehydrogenase [Lactobacillus helveticus]
>gi|1095459|prf||2109198A D-lactate dehydrogenase
[Lactobacillus helveticus]
Length = 337
Score = 111 bits (276), Expect = 9e-24
Identities = 81/317 (25%), Positives = 152/317 (47%), Gaps = 38/317 (11%)
Query: 22 YTDVVLKPYPSEEELKEIIPELDGIIIAPVTRITKDILERAERLKV--ISCQSAGYDHVD 79
YTD +L P E ++ DG+++ T D L+ V +S ++ G D++D
Sbjct: 31 YTDKLLTP-----ETAKLAKGADGVVVYQQLDYTADTLQALADAGVTKMSLRNVGVDNID 85
Query: 80 VEEATKRGIYVTKVSGLLSEAVAEFALGLLISLMRKIHYADSFIREGKWESHTFVWREFK 139
+++A + G +T V A+AE A ++R+ D + + + RE +
Sbjct: 86 MDKAKELGFQITNVPVYSPNAIAEHAAIQAARVLRQDKRMDEKMAKRDLRWAPTIGREVR 145
Query: 140 EVETLYGKEVGIVGMGAIGKAIARRLKPFGCEIYYWSRHRKEDIEREVNAKYLD-LDELL 198
+ + VG+VG G IG+ R ++ FG ++ + + ++E++ Y+D LD+L
Sbjct: 146 D------QVVGVVGTGHIGQVFMRIMEGFGAKVIAYDIFKNPELEKK--GYYVDSLDDLY 197
Query: 199 EEVDIVILALPLTKETYHIINEERVKKL-EGKYLVNIGRGALIDEKALVKAIKEGKLKGF 257
++ D++ L +P H+IN++ + ++ +G +VN RG L+D A+++ + GK+ GF
Sbjct: 198 KQADVISLHVPDVPANVHMINDKSIAEMKDGVVIVNCSRGRLVDTDAVIRGLDSGKIFGF 257
Query: 258 ATDVFEEEPVKEHELFRFKWE-----------------TVLTPHYAGLGKDVLEDMGFRA 300
D +E+E +F WE ++TPH A + +M +A
Sbjct: 258 VMDTYEDEV----GVFNKDWEGKEFPDKRLADLIDRPNVLVTPHTAFYTTHAVRNMVVKA 313
Query: 301 VENLLKVLRGEIPEDLV 317
N LK++ GE P+ V
Sbjct: 314 FNNNLKLINGEKPDSPV 330
>gb|AAC99363.1| (AF071558) D-lactate dehydrogenase [Lactobacillus johnsonii]
Length = 337
Score = 111 bits (276), Expect = 9e-24
Identities = 81/318 (25%), Positives = 154/318 (47%), Gaps = 38/318 (11%)
Query: 21 KYTDVVLKPYPSEEELKEIIPELDGIIIAPVTRITKDILERAERLKV--ISCQSAGYDHV 78
+YTD +L P E ++ DG+++ T + L+ V +S ++ G D++
Sbjct: 30 EYTDKLLAP-----ETAKLAKGADGVVVYQQLDYTPETLQALADAGVTKMSLRNVGVDNI 84
Query: 79 DVEEATKRGIYVTKVSGLLSEAVAEFALGLLISLMRKIHYADSFIREGKWESHTFVWREF 138
D+++A + G +T V +A+AE A ++R+ D + + + RE
Sbjct: 85 DMDKAKELGFEITNVPVYSPDAIAEHAAIQAARVLRQDKRMDEKMAKRDLRWAPTIGREV 144
Query: 139 KEVETLYGKEVGIVGMGAIGKAIARRLKPFGCEIYYWSRHRKEDIEREVNAKYLD-LDEL 197
++ + VG+VG G IG+ + ++ FG ++ + + ++E++ Y+D LD+L
Sbjct: 145 RD------QVVGVVGTGHIGQVFMKIMEGFGAKVIAYDIFKNPELEKK--GYYVDSLDDL 196
Query: 198 LEEVDIVILALPLTKETYHIINEERVKKL-EGKYLVNIGRGALIDEKALVKAIKEGKLKG 256
++ D++ L +P H+IN+E + K+ +G +VN RG L+D A+++ + GK+ G
Sbjct: 197 YKQADVISLHVPDVPANVHMINDESIAKMKDGVVIVNCSRGPLVDTDAVIRGLDSGKIFG 256
Query: 257 FATDVFEEEPVKEHELFRFKWE-----------------TVLTPHYAGLGKDVLEDMGFR 299
F D +E E +F WE ++TPH A + +M +
Sbjct: 257 FVMDTYEGEV----GVFNEDWEGKEFPDARLADLIDRPNVLVTPHTAFYTTHAVRNMVTK 312
Query: 300 AVENLLKVLRGEIPEDLV 317
A +N LK++ GE P+ V
Sbjct: 313 AFDNNLKMINGEKPDSPV 330
>sp|Q59642|LDHD_PEDAC D-LACTATE DEHYDROGENASE (D-LDH) >gi|897794|emb|CAA50275.1| (X70925)
D-lactate dehydrogenase [Pediococcus acidilactici]
Length = 331
Score = 111 bits (275), Expect = 1e-23
Identities = 66/250 (26%), Positives = 128/250 (50%), Gaps = 12/250 (4%)
Query: 20 KKYTDVVLKPYPSEEELKEIIPELDGIIIAPVTRITKDILERAERLKV--ISCQSAGYDH 77
K + +V P + ++ + DG++ T D+ ++ + S ++ G D+
Sbjct: 22 KNHIEVKAVPDLLDSSNIDLAKDYDGVVAYQQKPYTADLFDKMHEFGIHAFSLRNVGLDN 81
Query: 78 VDVEEATKRGIYVTKVSGLLSEAVAEFALGLLISLMRKIHYADSFIREGKWESHTFVWRE 137
V + K I ++ V A+AE ++ L++L+RKI + + G + + E
Sbjct: 82 VPADALKKNDIKISNVPAYSPRAIAELSVTQLLALLRKIPEFEYKMAHGDYRWEPDIGLE 141
Query: 138 FKEVETLYGKEVGIVGMGAIGKAIARRLKPFGCEIYYWSRHRKEDIEREVNAKYLD-LDE 196
++ VG++G G IG+A KPFG ++ + R +E+E Y+D L+E
Sbjct: 142 LNQMT------VGVIGTGRIGRAAIDIFKPFGAKVIAYDVFRNPALEKE--GMYVDTLEE 193
Query: 197 LLEEVDIVILALPLTKETYHIINEERVKKLE-GKYLVNIGRGALIDEKALVKAIKEGKLK 255
L ++ +++ L +P K+ YH+++E+ +++ G +++N RG L+D AL+KA+ GK+
Sbjct: 194 LYQQANVITLHVPALKDNYHMLDEKAFGQMQDGTFILNFARGTLVDTPALLKALDSGKVA 253
Query: 256 GFATDVFEEE 265
G A D +E E
Sbjct: 254 GAALDTYENE 263
>pir||C70645 hypothetical protein Rv0728c - Mycobacterium tuberculosis (strain
H37RV) >gi|3261700|emb|CAB06474.1| (Z84395) hypothetical
protein Rv0728c [Mycobacterium tuberculosis]
Length = 326
Score = 110 bits (273), Expect = 2e-23
Identities = 92/333 (27%), Positives = 150/333 (44%), Gaps = 24/333 (7%)
Query: 2 KPRIGVLFKMKSKPLEELKKYTDVVLKP---------YPSEEELKEIIPELDGIIIAPVT 52
+PR V ++ +L++ DVV P Y +E+ I +++
Sbjct: 4 RPRALVTAPLRGPGFAQLRRLADVVYDPWIDQRPLRIYSAEQLADRITAVAADVLVVESD 63
Query: 53 RITKDILERAERLKVISCQSAGYDHVDVEEATKRGIYVTKVSGLLSEAVAEFALGLLISL 112
+ + ER L+V++ +VD+ AT GI V ++AVAE + LL+++
Sbjct: 64 SVGGPVFERG--LRVVAATRGDPSNVDIPGATAAGIPVLHTPARNADAVAEMTVALLLAV 121
Query: 113 MRKIHYADSFIREGK-WESHTFVWREFKEVETLYGKEVGIVGMGAIGKAIARRLKPFGCE 171
R + AD+ +R G + T ++ F+ E + G G+VG+GA+G+A+ RL G
Sbjct: 122 ARHLIPADADVRSGNIFRDGTIPYQRFRGAE-IAGLTAGLVGLGAVGRAVRWRLSGLGLR 180
Query: 172 IYYWSRHRKEDIEREVNAKYLDLDELLEEVDIVILALPLTKETYHIINEERVKKL-EGKY 230
+ +R + LDELL E DIV + +T +T +I ++ + +G
Sbjct: 181 VIAHDPYRDDAGH--------SLDELLAEADIVSMHAAVTDDTIGMIGAQQFAAMRDGAV 232
Query: 231 LVNIGRGALIDEKALVKAIKEGKLKGFATDVFEEEPV-KEHELFRFKWETVLTPHYAGLG 289
+N R L D ALV A++ GKL D F E + +H L VLTPH G
Sbjct: 233 FLNTARSQLRDTDALVDALRGGKLAAAGLDHFTGEWLPTDHPLVSMP-NVVLTPHIGGAT 291
Query: 290 KDVLEDMGFRAVENLLKVLRGEIPEDLVNKEVL 322
+ ++L +L G P +VN EVL
Sbjct: 292 WNTEARQARMVADDLGALLSGNRPAHVVNPEVL 324
>pir||T34290 hypothetical protein F49E10.5 - Caenorhabditis elegans
>gi|1255868|gb|AAC69109.1| (U53341) similar to the
D-isomer specific 2-hdroxyacid dehydrogenases family
[Caenorhabditis elegans]
Length = 612
Score = 109 bits (271), Expect = 3e-23
Identities = 90/325 (27%), Positives = 148/325 (44%), Gaps = 29/325 (8%)
Query: 19 LKKYTDVVLKPYPSEEELKE-IIPELDGIIIAPVTRITKDILERAERLKVISCQSAGYDH 77
LK V S +E+ E ++ E ++ ++ K+ LE+ + LKV+ G D+
Sbjct: 77 LKDVATVAFCDAQSTQEIHEKVLNEAVAALMYHSIKLEKEDLEKFKVLKVVFRIGYGIDN 136
Query: 78 VDVEEATKRGIYVTKVSGLLSEAVAEFALGLLISLMRKIH-YADSFIREGKWESHTFVWR 136
+DV+ AT+ GI V G E VA+ L L++ L R+ + +A S+ K V
Sbjct: 137 IDVKAATELGIAVCHAPGDYVEDVADSTLSLILDLFRRTYWHAKSYSETRKTIGADQVRE 196
Query: 137 EFKEVETLYGKEVGIVGMGAIGKAIARRLKPFGCEIYYW-----SRHRKEDIEREVNAKY 191
+ + G +GI+G G +G A+ R + FG I ++ H K + +
Sbjct: 197 NAVGSKKVRGSVLGILGCGRVGTAVGLRARAFGLHIIFYDPFVREGHDKASVTDLELFRV 256
Query: 192 LDLDELLEEVDIVILALPLTKETYHIINEERVKKLE-GKYLVNIGRGALIDEKALVKAIK 250
+DE + D + L L ET IIN + +++ + G Y+VN LI+E L A+K
Sbjct: 257 YTMDEFMSRSDCISLHCNLGDETRGIINADSLRQCKSGVYIVNTSHAGLINENDLAAALK 316
Query: 251 EGKLKGFATDVFEEEPVKEHELFRFK----------WETVLTPHYAGLGKDVLEDMGFRA 300
G +KG A DV H+ RF + TPH A + + +D+ A
Sbjct: 317 NGHVKGAALDV--------HDSVRFDPNCLNPLVGCPNIINTPHSAWMTEASCKDLRINA 368
Query: 301 VENLLKVLRGEIPEDL---VNKEVL 322
+ + K + G P+DL +NKE +
Sbjct: 369 AKEIRKAINGRCPQDLTHCINKEAV 393
>emb|CAA04756.1| (AJ001428) D-mandelate dehydrogenase [Rhodotorula graminis]
>gi|2385384|emb|CAA04757.1| (AJ001429) D-mandelate
dehydrogenase [Rhodotorula graminis]
Length = 351
Score = 109 bits (271), Expect = 3e-23
Identities = 84/266 (31%), Positives = 131/266 (48%), Gaps = 13/266 (4%)
Query: 65 LKVISCQSAGYDHVDVEEATKRGIYVTKVSGLLSEAVAEFALGLLISLMRKIHYADSFIR 124
LKV + AG+D +D++ +RG+ G A ++ AL L++S+ R Y++ R
Sbjct: 81 LKVFAAAGAGFDWLDLDALNERGVAFANSRGAGDTATSDLALYLILSVFRLASYSERAAR 140
Query: 125 EGKWESHTFVWREF-KEVETLYGKEVGIVGMGAIGKAIARR-LKPFGCE-IYYWSRHRKE 181
G E+ V E K G +G VG+GAI K IAR+ + G + +YY
Sbjct: 141 TGDPETFNRVHLEIGKSAHNPRGHVLGAVGLGAIQKEIARKAVHGLGMKLVYYDVAPADA 200
Query: 182 DIEREVNAKYLD-LDELLEEVDIVILALPLTKETYHIINEERVKKLE-GKYLVNIGRGAL 239
+ E+ + A+ +D L+EL D V +++P K T+H+I+E ++ G +VN RG +
Sbjct: 201 ETEKALGAERVDSLEELARRSDCVSVSVPYMKLTHHLIDEAFFAAMKPGSRIVNTARGPV 260
Query: 240 IDEKALVKAIKEGKLKGFATDVFEEEPVKEHELFRFKWETVLTPHYAGLGKDVLEDMGFR 299
I + AL+ A+K GKL DV E EP EL K T LT H G+ + +
Sbjct: 261 ISQDALIAALKSGKLLSAGLDVHEFEPQVSKELIEMKHVT-LTTHIGGVAIETFHEFERL 319
Query: 300 AVENLLKVLRGEIPEDLVNKEVLKVR 325
+ N+ + L L K +L VR
Sbjct: 320 TMTNIDRFL-------LQGKPLLTVR 338
>prf||2124425A CtBP protein [Rattus norvegicus]
Length = 439
Score = 109 bits (270), Expect = 4e-23
Identities = 83/314 (26%), Positives = 146/314 (46%), Gaps = 24/314 (7%)
Query: 19 LKKYTDVVLKPYPSEEELKE-IIPELDGIIIAPVTRITKDILERAERLKVISCQSAGYDH 77
LK V S +E+ E ++ E G ++ +T++ LE+ + L++I +G+D+
Sbjct: 45 LKDVATVAFCDAQSTQEIHEKVLNEAVGALMYHTITLTREDLEKFKALRIIVRIGSGFDN 104
Query: 78 VDVEEATKRGIYVTKVSGLLSEAVAEFALGLLISLMRKI----------HYADSFIREGK 127
+D++ A GI V V E A+ L +++L R+ H + + R +
Sbjct: 105 IDIKSAGDLGIAVCNVPAASVEETADSTLCHILNLYRRATGCTRRCGRAHESRASSRSAR 164
Query: 128 WESHTFVWREFKEVETLYGKEVGIVGMGAIGKAIARRLKPFGCEIYYWSRHRKEDIEREV 187
W R + + G GA G+ + G + ++ + + +ER +
Sbjct: 165 WRPRCQDPRGDLGHHRTWSRGAG---SGAAGQRV-------GFNVLFYDPYLSDGVERAL 214
Query: 188 NAKYLD-LDELLEEVDIVILALPLTKETYHIINEERVKKL-EGKYLVNIGRGALIDEKAL 245
+ + L +LL D V L L + +H+IN+ VK++ +G +LVN RG L+DEKAL
Sbjct: 215 GLQRVSTLQDLLFHSDCVTLHCGLNEHNHHLINDFTVKQMRQGAFLVNTARGGLVDEKAL 274
Query: 246 VKAIKEGKLKGFATDVFEEEPVK-EHELFRFKWETVLTPHYAGLGKDVLEDMGFRAVENL 304
+A+KEG+++G A DV E EP + + TPH A + +M A +
Sbjct: 275 AQALKEGRIRGAALDVHESEPFSFSQGPLKDAPNLICTPHAAWYSEQASIEMREEAAREI 334
Query: 305 LKVLRGEIPEDLVN 318
+ + G IP+ L N
Sbjct: 335 RRAITGRIPDSLKN 348
>dbj|BAA13058.1| (D86240) unknown [Staphylococcus aureus]
Length = 200
Score = 109 bits (269), Expect = 6e-23
Identities = 66/193 (34%), Positives = 103/193 (53%), Gaps = 6/193 (3%)
Query: 27 LKPYPSEEELKEIIPELDGIIIAPVTRITKDILERAERLKVISCQSAGYDHVDVEEATKR 86
L P P +++ + + D I +I +IL ++ LKVI+ + GYD++DVE AT
Sbjct: 6 LVPMP-KDQFVTALRDADACFITLSEQIDAEILAQSPNLKVIANMAVGYDNIDVESATAN 64
Query: 87 GIYVTKVSGLLSEAVAEFALGLLISLMRKIHYADSFIREGKWESHTFVWREFKEVETLYG 146
+ VT +L+E AE L++++ R+I A+ ++ W+S K+V +
Sbjct: 65 NVVVTNTPNVLTETTAELGFTLMLAIARRIVEAEKYVEADAWQSWGPYLLSGKDV---FN 121
Query: 147 KEVGIVGMGAIGKAIARRLKPFGCEIYYWSRHRKEDIEREVNAKYLDLDELLEEVDIVIL 206
+GI GMG IGKA ARRL+ F I Y +R R +D E + NA Y+ + LL E + +
Sbjct: 122 STIGIYGMGDIGKAFARRLQGFNTNILYHNRSRHKDAEADFNATYVSFETLLAESVLSSV 181
Query: 207 ALPLTKETYHIIN 219
L K+ HIIN
Sbjct: 182 QRHLQKK--HIIN 192
>emb|CAA42781.1| (X60220) D-lactate dehydrogenase [Lactobacillus delbrueckii]
>gi|228094|prf||1717214A lactate dehydrogenase
[Lactobacillus delbrueckii]
Length = 333
Score = 106 bits (262), Expect = 4e-22
Identities = 77/315 (24%), Positives = 151/315 (47%), Gaps = 38/315 (12%)
Query: 21 KYTDVVLKPYPSEEELKEIIPELDGIIIAPVTRITKDILERA--ERLKVISCQSAGYDHV 78
+YTD +L P E + DG+++ T + L+ + +S ++ G D++
Sbjct: 30 EYTDKLLTP-----ETVALAKGADGVVVYQQLDYTAETLQALADNGITKMSLRNVGVDNI 84
Query: 79 DVEEATKRGIYVTKVSGLLSEAVAEFALGLLISLMRKIHYADSFIREGKWESHTFVWREF 138
D+ +A + G +T V A+AE A +++R+ D + + RE
Sbjct: 85 DMAKAKELGFQITNVPVYSPNAIAEHAAIQAAAILRQDKAMDEKVARHDLRWAPTIGREV 144
Query: 139 KEVETLYGKEVGIVGMGAIGKAIARRLKPFGCEIYYWSRHRKEDIEREVNAKYLD-LDEL 197
++ + VG++G G IG+ + ++ FG ++ + R ++E++ Y+D LD+L
Sbjct: 145 RD------QVVGVIGTGHIGQVFMQIMEGFGAKVITYDIFRNPELEKK--GYYVDSLDDL 196
Query: 198 LEEVDIVILALPLTKETYHIINEERVKKL-EGKYLVNIGRGALIDEKALVKAIKEGKLKG 256
++ D++ L +P H+IN+E + K+ + +VN+ RG L+D A+++ + GK+ G
Sbjct: 197 YKQADVISLHVPDVPANVHMINDESIAKMKQDVVIVNVSRGPLVDTDAVIRGLDSGKIFG 256
Query: 257 FATDVFEEEPVKEHELFRFKWE-----------------TVLTPHYAGLGKDVLEDMGFR 299
+A DV+E E +F WE ++TPH A + +M +
Sbjct: 257 YAMDVYEGEV----GIFNEDWEGKEFPDARLADLIARPNVLVTPHTAFYTTHAVRNMVVK 312
Query: 300 AVENLLKVLRGEIPE 314
A +N L+++ G+ E
Sbjct: 313 AFDNNLELVEGKEAE 327
>gb|AAG39286.1|AF113215_1 (AF113215) MSTP035 [Homo sapiens]
Length = 248
Score = 106 bits (262), Expect = 4e-22
Identities = 78/252 (30%), Positives = 129/252 (50%), Gaps = 20/252 (7%)
Query: 1 MKP-RIGVLFKMKSKPLE---ELKKYTDVVLKPYPSEE-----ELKEIIPELDGIIIAPV 51
M+P R+ +F + P E L + D ++ + S+E EL+ + G++
Sbjct: 1 MRPVRLMKVFVTRRIPAEGRVALARAADCEVEQWDSDEPIPAKELERGVAGAHGLLCLLS 60
Query: 52 TRITKDILERA-ERLKVISCQSAGYDHVDVEEATKRGIYVTKVSGLLSEAVAEFALGLLI 110
+ K IL+ A LKVIS S G DH+ ++E KRGI V +L++ AE A+ LL+
Sbjct: 61 DHVDKRILDAAGANLKVISTMSVGIDHLALDEIKKRGIRVGYTPDVLTDTTAELAVSLLL 120
Query: 111 SLMRKIHYADSFIREGKWESHTFVWREFKEVETLYG---KEVGIVGMGAIGKAIARRLKP 167
+ R++ A ++ G W S +W YG VGI+G+G IG+AIARRLKP
Sbjct: 121 TTCRRLPEAIEEVKNGGWTSWKPLWL------CGYGLTQSTVGIIGLGRIGQAIARRLKP 174
Query: 168 FGCEIY-YWSRHRKEDIEREVNAKYLDLDELLEEVDIVILALPLTKETYHIINEERVKKL 226
FG + + Y R + + E A+++ EL + D +++A LT T + N++ +K+
Sbjct: 175 FGVQRFLYTGRQPRPEEAAEFQAEFVSTPELAAQSDFIVVACSLTPATEGLCNKDFFQKM 234
Query: 227 EGKYLVNIGRGA 238
+ + + GA
Sbjct: 235 KEQLCSSTSAGA 246
>pir||T35499 probable D-lactate dehydrogenase - Streptomyces coelicolor
>gi|5689928|emb|CAB51966.1| (AL109661) putative
D-lactate dehydrogenase [Streptomyces coelicolor A3(2)]
Length = 331
Score = 105 bits (259), Expect = 9e-22
Identities = 76/266 (28%), Positives = 132/266 (49%), Gaps = 21/266 (7%)
Query: 66 KVISCQSAGYDHVDVEEATKRGIYVTKVSGLLSEAVAEFALGLLISLMRKIHYADSFIRE 125
++++ +S G+++VD++ A + G+ V +VS +VAEFA L +++ R+I A R+
Sbjct: 69 RMVAQRSTGFNNVDLDTADRLGMTVARVSYYSPHSVAEFAWALAMAVNRRIVRASIRTRD 128
Query: 126 GKWESHTFVWREFKEVETLYGKEVGIVGMGAIGKAIARRLKPFGCEIYYWSRHRKEDIER 185
+ + R+ L+G+ G++G G IG+A AR FG + W +
Sbjct: 129 FDFRLDGLMGRD------LHGRTAGVLGTGKIGEAFARIAHGFGMRLLGWD-VAENPACA 181
Query: 186 EVNAKYLDLDELLEEVDIVILALPLTKETYHIINEERVKKL-EGKYLVNIGRGALIDEKA 244
E+ +Y+ DELL D++ L +PL ET H+I+ +K + + L+N RG LID A
Sbjct: 182 ELGMRYVAKDELLARSDLITLHVPLMAETRHLIDATALKAMRDDAILINSSRGGLIDTAA 241
Query: 245 LVKAIKEGKLKGFATDVFEE-----------EPVKEHELFRFKW--ETVLTPHYAGLGKD 291
LV ++ G+ G DV+E E V++ L R ++T H A +D
Sbjct: 242 LVGELRAGRFAGVGLDVYEAEAGLFFLDKSLEAVEDDTLARLVTFPNVLVTSHQAYYTED 301
Query: 292 VLEDMGFRAVENLLKVLRGEIPEDLV 317
+ + V N+L G E+++
Sbjct: 302 AVGQIVGTTVRNVLDYREGRRSENVL 327
>pdb|1QP8|A Chain A, Crystal Structure Of A Putative Formate Dehydrogenase From
Pyrobaculum Aerophilum >gi|5542415|pdb|1QP8|B Chain B,
Crystal Structure Of A Putative Formate Dehydrogenase
From Pyrobaculum Aerophilum
Length = 303
Score = 104 bits (258), Expect = 1e-21
Identities = 88/302 (29%), Positives = 143/302 (47%), Gaps = 23/302 (7%)
Query: 29 PYPSEEELKEIIP-----ELDGIIIAPVTRITKDILERAERLKVISCQSAGYDHVDVEEA 83
P +EEEL++ +L + A V+RIT + L + RLK I +AG DH+ E
Sbjct: 10 PPEAEEELRKYFKIVRGGDLGNVEAALVSRITAEELAKXPRLKFIQVVTAGLDHLPWESI 69
Query: 84 TKRGIYVTKVSGLLSEAVAEFALGLLISLMRKIHYADSFIREGKWESHTFVWREFKEVET 143
+ V +G ++AVAEFAL LL++ ++I + G + E+
Sbjct: 70 PPH-VTVAGNAGSNADAVAEFALALLLAPYKRIIQYGEKXKRGDYGRDV-------EIPL 121
Query: 144 LYGKEVGIVGMGAIGKAIARRLKPFGCEIYYWSRHRKEDIEREVNAKYLDLDELLEEVDI 203
+ G++V ++G+G IG + + L G ++ +SR KE R N+ L+E L E
Sbjct: 122 IQGEKVAVLGLGEIGTRVGKILAALGAQVRGFSRTPKEGPWRFTNS----LEEALREARA 177
Query: 204 VILALPLTKETYHIINEERVK-KLEGKYLVNIGRGALIDEKALVKAIKEGKLKGFATDVF 262
+ ALPL K T ++ + + E VN+GR ++D +++ +KE FA+DV+
Sbjct: 178 AVCALPLNKHTRGLVKYQHLALXAEDAVFVNVGRAEVLDRDGVLRILKERPQFIFASDVW 237
Query: 263 --EEEPVKEHELFRFKWETVLTPHYA-GLGKD-VLEDMGFRAVENLLKVLRGEIPEDLVN 318
+ K+ E F V TP A G G + V AV NL+ G P ++
Sbjct: 238 WGRNDFAKDAEFFSLP-NVVATPWVAGGYGNERVWRQXVXEAVRNLITYATGGRPRNIAK 296
Query: 319 KE 320
+E
Sbjct: 297 RE 298
>pir||D75365 probable 2-hydroxyacid dehydrogenase - Deinococcus radiodurans
(strain R1) >gi|6459468|gb|AAF11256.1|AE002011_7
(AE002011) 2-hydroxyacid dehydrogenase, putative
[Deinococcus radiodurans]
Length = 311
Score = 104 bits (257), Expect = 1e-21
Identities = 81/274 (29%), Positives = 127/274 (45%), Gaps = 16/274 (5%)
Query: 42 ELDGIIIAPVTRITKDILERAERLKVISCQSAGYDHVDVEEATKRGIYVTKVSGLLSEAV 101
E G+++ T+D L L+ + +AG +HV + +G + L AV
Sbjct: 44 EAQGVVLWLANGATRDALLSVPGLQWVLTLTAGIEHV--QGKLPQGAALYNAHRLHDRAV 101
Query: 102 AEFALGLLISLMRKIHYADSFIREGKWESHTFVWREFKEVETLYGKEVGIVGMGAIGKAI 161
A + +++ R +H + G+W + + TL G++V + G G IGK +
Sbjct: 102 AVHVVAGMLAASRGLHRFRDAQQRGEWVRTSLA---DTGLSTLDGQKVVLWGYGHIGKIV 158
Query: 162 ARRLKPFGCEIYYWSRHRKEDIEREVNAKYLDLDELLEEVDIVILALPLTKETYHIINEE 221
L PFG ++Y + + D+ +D L E D V+L LP T+ T I+N E
Sbjct: 159 EELLAPFGAQVYGLTSKTEPDL----------VDYRLAEADWVVLLLPSTERTRGIVNAE 208
Query: 222 RVKKLE-GKYLVNIGRGALIDEKALVKAIKEGKLKGFATDVFEEEPVKEHELFRFKWETV 280
R+ L+ G +L N GRG LI L+ A+ G L G DV + EP+ + V
Sbjct: 209 RLTALKPGVWLSNQGRGDLIVTDDLLAALDSGHLGGAVLDVTDPEPLLAGHPLWDRENVV 268
Query: 281 LTPHYAGLGKDVLEDMGFRAVENLLKVLRGEIPE 314
+TPH A + D+LE A +L VL+G PE
Sbjct: 269 ITPHIASITSDLLERGAAYARSFILDVLQGRTPE 302
>pir||B82587 D-3-phosphoglycerate dehydrogenase XF2206 [imported] - Xylella
fastidiosa (strain 9a5c)
>gi|9107351|gb|AAF85005.1|AE004033_9 (AE004033)
D-3-phosphoglycerate dehydrogenase [Xylella fastidiosa]
Length = 413
Score = 104 bits (256), Expect = 2e-21
Identities = 82/283 (28%), Positives = 132/283 (45%), Gaps = 21/283 (7%)
Query: 33 EEELKEIIPELDGIIIAPVTRITKDILERAERLKVISCQSAGYDHVDVEEATKRGIYVTK 92
EE L+ I E I I T++ ++L A+RL I C G + VD++ A GI V
Sbjct: 46 EEALQAEIAEAHIIGIRSRTQLNAEVLGHAKRLMAIGCFCIGTNQVDLDTAELSGIPVFN 105
Query: 93 VSGLLSEAVAEFALGLLISLMRKIHYADSFIREGKWESHTFVWREFKEVETLYGKEVGIV 152
+ +VAE + I L+R I ++ G W E + GK +GIV
Sbjct: 106 APYSNTRSVAELIIAEAILLLRGIPQKNAECHRGGWSKSAINSHEAR------GKVLGIV 159
Query: 153 GMGAIGKAIARRLKPFGCEIYYWSRHRKEDIEREV---NAK-YLDLDELLEEVDIVILAL 208
G G IG ++ + G ++ ++ DIE ++ NA+ LDELL D+V L +
Sbjct: 160 GYGHIGTQVSVLAEAMGMQVIFY------DIESKLSLGNARPAASLDELLGIADVVTLHV 213
Query: 209 PLTKETYHIINEERVKKLE-GKYLVNIGRGALIDEKALVKAIKEGKLKGFATDVFEEEPV 267
P T T +++ + +++ G +L+N RG +++ AL A+ G L G A DVF EP
Sbjct: 214 PETAATKNMLGHAELARMKPGAHLINASRGTVVEIDALDAALVSGHLGGAAVDVFPSEPK 273
Query: 268 KEHELFRFKW----ETVLTPHYAGLGKDVLEDMGFRAVENLLK 306
+ F +LTPH G + +++G L++
Sbjct: 274 GNSDPFISPLSRHDNVILTPHIGGSTLEAQDNIGIEVAAKLIR 316
>pir||C82118 erythronate-4-phosphate dehydrogenase VC2108 [imported] - Vibrio
cholerae (group O1 strain N16961)
>gi|9656658|gb|AAF95254.1| (AE004284)
erythronate-4-phosphate dehydrogenase [Vibrio cholerae]
Length = 387
Score = 102 bits (253), Expect = 4e-21
Identities = 75/272 (27%), Positives = 132/272 (47%), Gaps = 38/272 (13%)
Query: 24 DVVLKPYPSEEELKEIIPELDGIIIAPVTRITKDILERAERLKVISCQSAGYDHVDVEEA 83
+V+LKP + + ++D ++I VT++ +L +A RLK + +AG DHVD
Sbjct: 27 EVILKP--GRTLTADDLIDVDALMIRSVTKVNDALLAKANRLKFVGTATAGMDHVDQALL 84
Query: 84 TKRGIYVTKVSGLLSEAVAEFALGLLISLMRKIHYADSFIREGKWESHTFVWREFKEVET 143
+RGI+ T G VAE+ +L+ L ++ + +
Sbjct: 85 RERGIFFTAAPGCNKVGVAEYVFSVLMVLAQQQGF------------------------S 120
Query: 144 LYGKEVGIVGMGAIGKAIARRLKPFGCEIYYWSRHRK-EDIEREVNAKYLDLDELLEEVD 202
++ K VGI+G G +G +A+ L G ++ ++ + ERE + +L+ LL++ D
Sbjct: 121 VFDKTVGIIGAGQVGSYLAKCLSGIGMKVLLNDPPKQAQGDERE----FTELETLLKQAD 176
Query: 203 IVILALPLTK----ETYHIINEERVKKLEG-KYLVNIGRGALIDEKALVKAIKEGKLKGF 257
++ L P+T+ T+H+I+ +++L + L+N RG ++D AL +++G
Sbjct: 177 VITLHTPITRGGEWPTHHLIDAAILEQLRSDQILINAARGPVVDNAALKARLQQGDGFTA 236
Query: 258 ATDVFEEEPVKEHELFRFKWETVLTPHYAGLG 289
DVFE EP + EL TPH AG G
Sbjct: 237 VLDVFEFEPQVDMELLPLL--AFATPHIAGYG 266
>sp|P26297|LDHD_LACDE D-LACTATE DEHYDROGENASE (D-LDH) >gi|538959|pir||A38094 D-lactate
dehydrogenase (EC 1.1.1.28) - Lactobacillus delbrueckii
subsp. bulgaricus >gi|149577|gb|AAA25246.1| (M85224)
D-lactate dehydrogenase [Lactobacillus delbrueckii]
Length = 333
Score = 102 bits (252), Expect = 6e-21
Identities = 77/311 (24%), Positives = 150/311 (47%), Gaps = 30/311 (9%)
Query: 21 KYTDVVLKPYPSEEELKEIIPELDGIIIAPVTRITKDILERA--ERLKVISCQSAGYDHV 78
+YTD +L P E + DG+++ T + L+ + +S ++ G D++
Sbjct: 30 EYTDKLLTP-----ETAALAKGADGVVVYQQLDYTAETLQALADNGITKMSLRNVGVDNI 84
Query: 79 DVEEATKRGIYVTKVSGLLSEAVAEFALGLLISLMRKIHYADSFIREGKWESHTFVWREF 138
D+ +A + G +T V A+AE A ++R+ D + + RE
Sbjct: 85 DMAKAKELGFQITNVPVYSPNAIAEHAAIQAARILRQAKAMDEKVARHDLRWAPTIGREV 144
Query: 139 KEVETLYGKEVGIVGMGAIGKAIARRLKPFGCEIYYWSRHRKEDIEREVNAKYLD-LDEL 197
++ + VG+VG G IG+ + ++ FG ++ + R ++E++ Y+D LD+L
Sbjct: 145 RD------QVVGVVGTGHIGQVFMQIMEGFGAKVIAYDIFRNPELEKK--GYYVDSLDDL 196
Query: 198 LEEVDIVILALPLTKETYHIINEERVKKL-EGKYLVNIGRGALIDEKALVKAIKEGKLKG 256
++ D++ L +P H+IN++ + K+ + +VN+ RG L+D A+++ + GK+ G
Sbjct: 197 YKQADVISLHVPDVPANVHMINDKSIAKMKQDVVIVNVSRGPLVDTDAVIRGLDSGKVFG 256
Query: 257 FATDVFEEE--------PVKEHELFRF-----KWETVLTPHYAGLGKDVLEDMGFRAVEN 303
+A DV+E E KE R + ++TPH A + +M +A +N
Sbjct: 257 YAMDVYEGEVGVFNEDREGKEFPDARLADLIARPNVLVTPHTAFYTTHAVRNMVVKAFDN 316
Query: 304 LLKVLRGEIPE 314
L+++ G+ E
Sbjct: 317 NLELVEGKEAE 327
>pir||JC7190 D-2-hydroxy-acid dehydrogenase (EC 1.1.99.6) - human
>gi|5852418|gb|AAD54066.1|AF113251_1 (AF113251) putative
2-hydroxyacid dehydrogenase [Homo sapiens]
Length = 248
Score = 101 bits (250), Expect = 1e-20
Identities = 80/253 (31%), Positives = 120/253 (46%), Gaps = 16/253 (6%)
Query: 72 SAGYDHVDVEEATKRGIYVTKVSGLLSEAVAEFALGLLISLMRKIHYADSFIREGKWESH 131
S G DH+ ++E KRGI V +L+ SL H + G S
Sbjct: 2 SVGIDHLALDEIKKRGIRVGYTPDVLTRYHRRTR-----SLPATYHLPP--VAGGHRGSE 54
Query: 132 TFVWREFKEVETL-YG---KEVGIVGMGAIGKAIARRLKPFGCEIY-YWSRHRKEDIERE 186
+ W +K + YG VGI+G+G IG+AIARRLKPFG + + Y R + + E
Sbjct: 55 EWWWTSWKPLWLCGYGLTQSTVGIIGLGRIGQAIARRLKPFGVQRFLYTGRQPRPEEAAE 114
Query: 187 VNAKYLDLDELLEEVDIVILALPLTKETYHIINEERVKKL-EGKYLVNIGRGALIDEKAL 245
A+++ EL + D +++A LT T + N++ +K+ E +NI RG ++++ L
Sbjct: 115 FQAEFVSTPELAAQSDFIVVACSLTPATEGLCNKDFFQKMKETAVFINISRGDVVNQDDL 174
Query: 246 VKAIKEGKLKGFATDVFEEEPVK-EHELFRFKWETVLTPHYAGLGKDVLEDMGFRAVENL 304
+A+ GK+ DV EP+ H L K V+ PH M A NL
Sbjct: 175 YQALASGKIAAAGLDVTSPEPLPTNHPLLTLK-NCVILPHIGSATHRTRNTMSLLAANNL 233
Query: 305 LKVLRGE-IPEDL 316
L LRGE +P +L
Sbjct: 234 LAGLRGEPMPSEL 246
>emb|CAC04225.1| (AL391515) putative dehydrogenase [Streptomyces coelicolor A3(2)]
Length = 312
Score = 100 bits (246), Expect = 3e-20
Identities = 76/274 (27%), Positives = 127/274 (45%), Gaps = 18/274 (6%)
Query: 54 ITKDI------LERAERLKVISCQSAGYDHVDVE-EATKRGIYVTKVSGLLSEAVAEFAL 106
+TKDI L RL+ + S+G D + E + R + + + + AE AL
Sbjct: 49 LTKDIDVIDRPLPHMTRLRAVQALSSGTDELRAELDRLPRPVTLCNAGAAPAPSTAELAL 108
Query: 107 GLLISLMRKIHYADSFIREGKWESHTFVWREFKEVETLYGKEVGIVGMGAIGKAIARRLK 166
L+++ +R I + G W F +LYG+ V +VG GA+G A+ L
Sbjct: 109 TLILASLRGIPESVRAQDGGAWGPEVF--------PSLYGRSVLVVGYGAVGSALEELLV 160
Query: 167 PFGCEIYYWSRHRKEDIEREVNAKYLDLDELLEEVDIVILALPLTKETYHIINEERVKKL 226
PFGC + + D R L L+ + D+V+L+ PLT +T + + + ++
Sbjct: 161 PFGCAVTRVA-GADRDAPRGPVRSAAHLPRLVSDADVVVLSTPLTPQTRQLFDAGMLARM 219
Query: 227 -EGKYLVNIGRGALIDEKALVKAIKEGKLKGFATDVFEEEPVKEHELFRFKWETVLTPHY 285
+G LVN+ RGA++D AL+K EG+L+ A DV + EP+ R ++TPH
Sbjct: 220 KDGALLVNVARGAVVDTDALLKETHEGRLRA-ALDVTDPEPLPPGHPLRETPGVLITPHV 278
Query: 286 AGLGKDVLEDMGFRAVENLLKVLRGEIPEDLVNK 319
+ + L + GE E++V++
Sbjct: 279 GAFTSSLWPRLEQLIRHQLSRFAAGEELENIVSR 312
>pir||S51787 D-2-hydroxyisocaproate dehydrogenase (EC 1.1.1.-) - Lactobacillus
delbrueckii subsp. bulgaricus >gi|509245|emb|CAA46324.1|
(X65222) D-hydroxyisocaproate dehydrogenase
[Lactobacillus delbrueckii]
Length = 333
Score = 99.5 bits (244), Expect = 5e-20
Identities = 69/268 (25%), Positives = 123/268 (45%), Gaps = 20/268 (7%)
Query: 65 LKVISCQSAGYDHVDVEEATKRGIYVTKVSGLLSEAVAEFALGLLISLMRKIHYADSFIR 124
+K I + G++ ++ + K + VT V A+AE + + L+RKI R
Sbjct: 71 VKCIGLRIVGFNTINFDWTKKYNLLVTNVPVYSPRAIAEMTVTQAMYLLRKI----GEFR 126
Query: 125 EGKWESHTFVWREFKEVETLYGKEVGIVGMGAIGKAIARRLKPFGCEIYYWSRHRKEDIE 184
H F W +Y VG++G+G IG +A G ++ + + E
Sbjct: 127 YRMDHDHDFTWPSNLISNEIYNLTVGLIGVGHIGSGLAEIFSAMGAKVIAYDVAYNPEFE 186
Query: 185 REVNAKYLDLDELLEEVDIVILALPLTKETYHIINEERVKKLE-GKYLVNIGRGALIDEK 243
+ Y D D +L+E DIV L PL T ++I E+++K+++ YL+N RG L+D
Sbjct: 187 PFLT--YTDFDTVLKEADIVSLHTPLFPSTENMIGEKQLKEMKKSAYLINCARGELVDTG 244
Query: 244 ALVKAIKEGKLKGFATDVF-------------EEEPVKEHELFRFKWETVLTPHYAGLGK 290
AL+KA+++G++ G D + E ++++ V+TPH A +
Sbjct: 245 ALIKALQDGEIAGAGLDTLAGESSYFGHTGLTDSEIPEDYKTLAKMPNVVITPHSAFYTE 304
Query: 291 DVLEDMGFRAVENLLKVLRGEIPEDLVN 318
+ +M + + L + +G P +VN
Sbjct: 305 TSIRNMVQICLTDQLTIAKGRRPRSIVN 332
>sp|P17584|DHD2_LACCA D-2-HYDROXYISOCAPROATE DEHYDROGENASE (D-HICDH)
>gi|2392297|pdb|1DXY| Structure Of
D-2-Hydroxyisocaproate Dehydrogenase
Length = 333
Score = 98.7 bits (242), Expect = 9e-20
Identities = 76/297 (25%), Positives = 148/297 (49%), Gaps = 26/297 (8%)
Query: 33 EEELKEIIPELDGIIIAPVTRITKDILER--AERLKVISCQSAGYDHVDVEEATKRGIYV 90
+E E DGI T + E+ A +K ++ ++ G D++D+ + GI +
Sbjct: 35 DENTVEWAKGFDGINSLQTTPYAAGVFEKMHAYGIKFLTIRNVGTDNIDMTAMKQYGIRL 94
Query: 91 TKVSGLLSEAVAEFALGLLISLMRKIHYADSFIREGKWE-SHTFVWREFKEVETLYGKEV 149
+ V A+AEFAL + L+R + + ++ G +E + TF+ +E + + V
Sbjct: 95 SNVPAYSPAAIAEFALTDTLYLLRNMGKVQAQLQAGDYEKAGTFIGKELGQ------QTV 148
Query: 150 GIVGMGAIGKAIARRLKPFGCEIYYWSRHRKEDIEREVNAKYLDLDELLEEVDIVILALP 209
G++G G IG+ + K FG ++ + + + + + Y+ L++L ++ D++ L +P
Sbjct: 149 GVMGTGHIGQVAIKLFKGFGAKVIAYDPYPMKGDHPDFD--YVSLEDLFKQSDVIDLHVP 206
Query: 210 LTKETYHIINEERVKKLE-GKYLVNIGRGALIDEKALVKAIKEGKLKGFATDVFEEEP-- 266
++ HIINE ++ G ++N R LID +A++ +K GKL G D +E E
Sbjct: 207 GIEQNTHIINEAAFNLMKPGAIVINTARPNLIDTQAMLSNLKSGKLAGVGIDTYEYETED 266
Query: 267 ---VKEHELFRFK-WE-------TVLTPHYAGLGKDVLEDMGFRAVENLLKVL-RGE 311
+ +H F+ W+ VL+PH A + + +M + ++++L+ L +GE
Sbjct: 267 LLNLAKHGSFKDPLWDELLGMPNVVLSPHIAYYTETAVHNMVYFSLQHLVDFLTKGE 323
>emb|CAC11987.1| (AL445065) glycerate dehydrogenase related protein [Thermoplasma
acidophilum]
Length = 303
Score = 98.7 bits (242), Expect = 9e-20
Identities = 74/275 (26%), Positives = 133/275 (47%), Gaps = 18/275 (6%)
Query: 53 RITKDILERAERLKVISCQSAGYDHVDVEEATKRGIYVTKVSGLLSEAVAEFALGLLISL 112
++ KD +R K+I SAG DH+DV + + +G S +VAE A LL++
Sbjct: 38 QVIKDRYVLGKRTKMIQAISAGVDHIDVN-GIPENVVLCSNAGAYSISVAEHAFALLLAH 96
Query: 113 MRKIHYADSFIREGKWESHTFVWREFKEVETLYGKEVGIVGMGAIGKAIARRLKPFGCEI 172
+ I + ++ G ++R+ LYGK +GI+G G IG+ +A K FG +
Sbjct: 97 AKNILENNELMKAG-------IFRQ-SPTTLLYGKALGILGYGGIGRRVAHLAKAFGMRV 148
Query: 173 YYWSRHRKEDIEREVNAKYLDLDELLEEVDIVILALPLTKETYHIINEERVKKL-EGKYL 231
++R +++ V+ +L + D V++A+PLT +T ++N + + +
Sbjct: 149 IAYTR---SSVDQNVDVISESPADLFRQSDFVLIAIPLTDKTRGMVNSRLLANARKNLTI 205
Query: 232 VNIGRGALIDEKALVKAIKEGKLKGFATDVFEEEPVKEHELFRFKWETVLTPHYAGLGKD 291
VN+ R ++ + ++ +KE + +DV+ EP R +L+PH AG
Sbjct: 206 VNVARADVVSKPDMIGFLKERSDVWYLSDVWWNEPEITETNLR---NAILSPHVAGGMSG 262
Query: 292 VLEDMGFR-AVENLLKVLRGEIPEDLVNKEVLKVR 325
+ D+ + A EN+ G P ++V KE +VR
Sbjct: 263 EIMDIAIQLAFENVRNFFEGH-PRNVVRKEEYRVR 296
>pir||DELBC D-2-hydroxyisocaproate dehydrogenase (EC 1.1.1.-) - Lactobacillus
casei >gi|149538|gb|AAA25236.1| (M26929)
D-2-hydroxyisocaproate dehydrogenase [Lactobacillus
casei]
Length = 335
Score = 98.3 bits (241), Expect = 1e-19
Identities = 74/293 (25%), Positives = 145/293 (49%), Gaps = 25/293 (8%)
Query: 33 EEELKEIIPELDGIIIAPVTRITKDILER--AERLKVISCQSAGYDHVDVEEATKRGIYV 90
+E E DGI T + E+ A +K ++ ++ G D++D+ + GI +
Sbjct: 35 DENTVEWAKGFDGINSLQTTPYAAGVFEKMHAYGIKFLTIRNVGTDNIDMTAMKQYGIRL 94
Query: 91 TKVSGLLSEAVAEFALGLLISLMRKIHYADSFIREGKWE-SHTFVWREFKEVETLYGKEV 149
+ V A+AEFAL + L+R + + ++ G +E + TF+ +E + + V
Sbjct: 95 SNVPAYSPAAIAEFALTDTLYLLRNMGKVQAQLQAGDYEKAGTFIGKELGQ------QTV 148
Query: 150 GIVGMGAIGKAIARRLKPFGCEIYYWSRHRKEDIEREVNAKYLDLDELLEEVDIVILALP 209
G++G G IG+ + K FG ++ + + + + + Y+ L++L ++ D++ L +P
Sbjct: 149 GVMGTGHIGQVAIKLFKGFGAKVIAYDPYPMKGDHPDFD--YVSLEDLFKQSDVIDLHVP 206
Query: 210 LTKETYHIINEERVKKLE-GKYLVNIGRGALIDEKALVKAIKEGKLKGFATDVFEEEP-- 266
++ HIINE ++ G ++N R LID +A++ +K GKL G D +E E
Sbjct: 207 GIEQNTHIINEAAFNLMKPGAIVINTARPNLIDTQAMLSNLKSGKLAGVGIDTYEYETED 266
Query: 267 ---VKEHELFRFK-WE-------TVLTPHYAGLGKDVLEDMGFRAVENLLKVL 308
+ +H F+ W+ VL+PH A + + +M + ++++L+ L
Sbjct: 267 LLNLAKHGSFKDPLWDELLGMPNVVLSPHIAYYTETAVHNMVYFSLQHLVDFL 319
>pir||S48145 D-hydroxyisocaproate dehydrogenase - Lactobacillus delbrueckii
Length = 333
Score = 98.3 bits (241), Expect = 1e-19
Identities = 69/267 (25%), Positives = 122/267 (44%), Gaps = 20/267 (7%)
Query: 66 KVISCQSAGYDHVDVEEATKRGIYVTKVSGLLSEAVAEFALGLLISLMRKIHYADSFIRE 125
K I + G++ ++ + K + VT V A+AE + + L+RKI R
Sbjct: 72 KCIGLRIVGFNTINFDWTKKYNLLVTNVPVYSPRAIAEMTVTQAMYLLRKI----GEFRY 127
Query: 126 GKWESHTFVWREFKEVETLYGKEVGIVGMGAIGKAIARRLKPFGCEIYYWSRHRKEDIER 185
H F W +Y VG++G+G IG +A G ++ + + E
Sbjct: 128 RMDHDHDFTWPSNLISNEIYNLTVGLIGVGHIGSGLAEIFSAMGAKVIAYDVAYNPEFEP 187
Query: 186 EVNAKYLDLDELLEEVDIVILALPLTKETYHIINEERVKKLE-GKYLVNIGRGALIDEKA 244
+ Y D D +L+E DIV L PL T ++I E+++K+++ YL+N RG L+D A
Sbjct: 188 FLT--YTDFDTVLKEADIVSLHHPLFPSTENMIGEKQLKEMKKSAYLINCARGELVDTGA 245
Query: 245 LVKAIKEGKLKGFATDVF-------------EEEPVKEHELFRFKWETVLTPHYAGLGKD 291
L+KA+++G++ G D + E ++++ V+TPH A +
Sbjct: 246 LIKALQDGEIAGAGLDTLAGESSYFGHTGLTDSEIPEDYKTLAKMPNVVITPHSAFYTET 305
Query: 292 VLEDMGFRAVENLLKVLRGEIPEDLVN 318
+ +M + + L + +G P +VN
Sbjct: 306 SIRNMVQICLTDQLTIAKGRRPRSIVN 332
>gb|AAG19748.1| (AE005060) phosphoglycerate dehydrogenase; SerA2 [Halobacterium sp.
NRC-1]
Length = 234
Score = 97.1 bits (238), Expect = 3e-19
Identities = 72/243 (29%), Positives = 122/243 (49%), Gaps = 13/243 (5%)
Query: 80 VEEATKRGIYVTKVSGLLSEAVAEFALGLLISLMRKIHYADSFIREGKWESHTFVWREFK 139
++ +RG+ VT +G+ + ++AE LG +++ R +H EG +R ++
Sbjct: 1 MDRLRERGVAVTNAAGIHAPSIAEQVLGSVLTFARNLH-------EGWRRQQRREYRHYQ 53
Query: 140 EVETLYGKEVGIVGMGAIGKAIARRLKPFGCEIY--YWSRHRKEDIEREVNAKYLDLDEL 197
E L G V +VG+GAIG A+ RL+ F + ++ + + + + +
Sbjct: 54 AHE-LGGSTVTVVGLGAIGHAVVDRLQGFDVDTIGVRYTPSKGGPTDEVIGFDDAAVHDA 112
Query: 198 LEEVDIVILALPLTKETYHIINEERVKKLEGK-YLVNIGRGALIDEKALVKAIKEGKLKG 256
L D ++LA PLT T +I+ L + LVN+ RG ++D ALV AI+ ++G
Sbjct: 113 LARTDYLVLATPLTDTTRGLIDAAAFDTLPPESVLVNVARGGVVDTDALVTAIRRQSIRG 172
Query: 257 FATDVFEEEPVKE-HELFRFKWETVLTPHYAGLGKDVLEDMGFRAVENLLKVLRGEIPED 315
A DV + EP+ E H L+ F+ +LTPH AG D + ENL ++ G+ E+
Sbjct: 173 AALDVTDPEPLPEDHPLWNFE-NVLLTPHNAGHTPDYWPRLADIVAENLSRLDAGDSLEN 231
Query: 316 LVN 318
V+
Sbjct: 232 RVD 234
>gb|AAG18731.1| (AE004977) phosphoglycerate dehydrogenase; SerA3 [Halobacterium sp.
NRC-1]
Length = 323
Score = 94.4 bits (231), Expect = 2e-18
Identities = 66/274 (24%), Positives = 116/274 (42%), Gaps = 9/274 (3%)
Query: 44 DGIIIAPVTRITKDILERAER-LKVISCQSAGYDHVDVEEATKRGIYVTKVSGLLSEAVA 102
D ++ P T + + + + + I G D +D A G+ V + V
Sbjct: 51 DAVVGGPETPVPAETIAEIDGDVAAIVRAGVGVDAIDCAAAADHGVAVANAPSYCTREVG 110
Query: 103 EFALGLLISLMRKIHYADSFIREGKWESHTFVWREFKEVETLYGKEVGIVGMGAIGKAIA 162
E AL L+ R++H D R G W W + L VG VG G I + +A
Sbjct: 111 EHALSLVFGAARRLHEYDRQTRRGGW-----AWNDAPAPLRLADATVGFVGFGEIARGVA 165
Query: 163 RRLKPFGCEIYYWSRHRKEDIEREVNAKYLDLDELLEEVDIVILALPLTKETYHIINEER 222
+ + + + + + + D++++ PLT+ET +++E
Sbjct: 166 DTATTVAESVIAYDPYVDAATAERHGVAMAEFEAVCAQSDVLVVFAPLTEETRGLVDEAA 225
Query: 223 VKKL-EGKYLVNIGRGALIDEKALVKAIKEGKLKGFATDVFEEEPVKEHELFRFKWETVL 281
+L EG +VN+GRGA++D+ AL A+++G + A DV EP E L + + ++
Sbjct: 226 CNRLPEGAVVVNVGRGAVVDDAALAGALEDGPVSAAALDVLPTEPPVESPLVG-RSDVLV 284
Query: 282 TPHYAGLGKDVLEDMGFRAVENLLKVLRGE-IPE 314
TPH + E + + V G+ +PE
Sbjct: 285 TPHCGWYSEAAAESLVASLAGTVAAVADGDGVPE 318
>sp|P05459|PDXB_ECOLI ERYTHRONATE-4-PHOSPHATE DEHYDROGENASE >gi|65958|pir||DEECPP
probable erythronate-4-phosphate dehydrogenase (EC
1.1.1.-) - Escherichia coli >gi|147124|gb|AAA24308.1|
(M29962) erythronate-4-phosphate dehydrogenase
[Escherichia coli] >gi|1684788|gb|AAB36530.1| (U76961)
4-phosphoerythronate dehydrogenase [Escherichia coli]
>gi|1788660|gb|AAC75380.1| (AE000321)
erythronate-4-phosphate dehyrogenase [Escherichia coli
K12] >gi|1799713|dbj|BAA16177.1| (D90863) probable
erythronate-4-phosphate dehydrogenase (EC 1.1.1.-)
[Escherichia coli]
Length = 378
Score = 93.6 bits (229), Expect = 3e-18
Identities = 76/274 (27%), Positives = 126/274 (45%), Gaps = 40/274 (14%)
Query: 19 LKKYTDVVLKPYPSEEELKEIIPELDGIIIAPVTRITKDILERAERLKVISCQSAGYDHV 78
L + T V +P P + + + D +++ VT++ + +L + +K + +AG DHV
Sbjct: 19 LGEVTAVPGRPIPVAQ-----LADADALMVRSVTKVNESLLA-GKPIKFVGTATAGTDHV 72
Query: 79 DVEEATKRGIYVTKVSGLLSEAVAEFALGLLISLMRKIHYADSFIREGKWESHTFVWREF 138
D + GI + G + AV E+ L+ L + D F
Sbjct: 73 DEAWLKQAGIGFSAAPGCNAIAVVEYVFSSLLMLAER----DGF---------------- 112
Query: 139 KEVETLYGKEVGIVGMGAIGKAIARRLKPFGCEIYYWSRHRKEDIEREVNAKYLDLDELL 198
+LY + VGIVG+G +G+ + RL+ G + R + R + LDEL+
Sbjct: 113 ----SLYDRTVGIVGVGNVGRRLQARLEALGIKTLLCDPPRAD---RGDEGDFRSLDELV 165
Query: 199 EEVDIVILALPLTKE----TYHIINEERVKKLE-GKYLVNIGRGALIDEKALVKAIKEGK 253
+ DI+ PL K+ T H+ +E+ ++ L+ G L+N RGA++D AL+ + EG+
Sbjct: 166 QRADILTFHTPLFKDGPYKTLHLADEKLIRSLKPGAILINACRGAVVDNTALLTCLNEGQ 225
Query: 254 LKGFATDVFEEEPVKEHELFRFKWETVLTPHYAG 287
DV+E EP EL K + T H AG
Sbjct: 226 KLSVVLDVWEGEPELNVEL--LKKVDIGTSHIAG 257
>sp|P51011|LDHD_LEUMC D-LACTATE DEHYDROGENASE (D-LDH) >gi|508506|gb|AAA99506.1| (L29327)
D-lactate dehydrogenase [Leuconostoc mesenteroides]
Length = 331
Score = 93.2 bits (228), Expect = 4e-18
Identities = 76/311 (24%), Positives = 143/311 (45%), Gaps = 34/311 (10%)
Query: 22 YTDVVLKPYPSEEELKEIIPELDGIIIAPVTRITKDILERAERLKV--ISCQSAGYDHVD 79
YT +L P E ++ D ++ T++ L + V +S ++ G D++D
Sbjct: 30 YTQELLTP-----ETAKLAEGSDSAVVYQQLDYTRETLTALANVGVTNLSLRNVGTDNID 84
Query: 80 VEEATKRGIYVTKVSGLLSEAVAEFALGLLISLMRKIHYADSFI--REGKWESHTFVWRE 137
+ A + ++ V A+AE ++ L L+R+ D+ I R+ +W T RE
Sbjct: 85 FDAAREFNFNISNVPVYSPNAIAEHSMLQLSRLLRRTKALDAKIAKRDLRWAPTT--GRE 142
Query: 138 FKEVETLYGKEVGIVGMGAIGKAIARRLKPFGCEIYYWSRHRKEDIEREVNAKYLD-LDE 196
+ + VG++G G IG+ LK FG ++ + ++ +++ E Y+D LDE
Sbjct: 143 MRM------QTVGVIGTGHIGRVAINILKGFGAKVIAYDKYPNAELQAE--GLYVDTLDE 194
Query: 197 LLEEVDIVILALPLTKETYHIINEERVKKL-EGKYLVNIGRGALIDEKALVKAIKEGKLK 255
L + D + L +P E +H+IN + + K+ +G ++N RG L+D A++ + GK+
Sbjct: 195 LYAQADAISLYVPGVPENHHLINADAIAKMKDGVVIMNAARGNLMDIDAIIDGLNSGKIS 254
Query: 256 GFATDVFEEEPVKEHELFRFK-------------WETVLTPHYAGLGKDVLEDMGFRAVE 302
F DV+E E ++ K ++TPH A + +M ++ +
Sbjct: 255 DFGMDVYENEVACSMKIGLVKNSPDAKIADLIARENVMITPHTAFYTTKAVLEMVHQSFD 314
Query: 303 NLLKVLRGEIP 313
+ +GE P
Sbjct: 315 AAVAFAKGEKP 325
>gb|AAD51414.1|AF171236_1 (AF171236) 3-phosphoglycerate dehydrogenase [Homo sapiens]
Length = 405
Score = 93.2 bits (228), Expect = 4e-18
Identities = 55/200 (27%), Positives = 99/200 (49%), Gaps = 8/200 (4%)
Query: 124 REGKWESHTFVWREFKEVETLYGKEVGIVGMGAIGKAIARRLKPFGCEIYYWSRHRKEDI 183
++GKWE F+ E L GK +GI+G+G IG+ +A R++ FG + + ++
Sbjct: 1 KDGKWERKKFMGTE------LNGKTLGILGLGRIGREVATRMQSFGMKTIGYDPIISPEV 54
Query: 184 EREVNAKYLDLDELLEEVDIVILALPLTKETYHIINEERVKKLE-GKYLVNIGRGALIDE 242
+ L L+E+ D + + PL T ++N+ + + G +VN RG ++DE
Sbjct: 55 SASFGVQQLPLEEIWPLCDFITVHTPLLPSTTGLLNDNTFAQCKKGVRVVNCARGGIVDE 114
Query: 243 KALVKAIKEGKLKGFATDVFEEEPVKEHELFRFKWETVLTPHYAGLGKDVLEDMGFRAVE 302
AL++A++ G+ G A DVF EEP ++ L + + PH K+ G
Sbjct: 115 GALLRALQSGQCAGAALDVFTEEPPRDRALVDHE-NVISCPHLGASTKEAQSRCGEEIAV 173
Query: 303 NLLKVLRGEIPEDLVNKEVL 322
+ +++G+ +VN + L
Sbjct: 174 QFVDMVKGKSLTGVVNAQAL 193
>gi|6321253 Ygl185cp [Saccharomyces cerevisiae]
>gi|1723944|sp|P53100|YGT5_YEAST HYPOTHETICAL 43.0 KD
PROTEIN IN COX4-GTS1 INTERGENIC REGION
>gi|2131615|pir||S61132 hypothetical protein YGL185c -
yeast (Saccharomyces cerevisiae)
>gi|1143562|emb|CAA62789.1| (X91489) putative
D-2-hydroxiacid dehydrogenase [Saccharomyces cerevisiae]
>gi|1322801|emb|CAA96897.1| (Z72707) ORF YGL185c
[Saccharomyces cerevisiae]
Length = 379
Score = 92.4 bits (226), Expect = 6e-18
Identities = 84/297 (28%), Positives = 136/297 (45%), Gaps = 35/297 (11%)
Query: 54 ITKDILERA----ERLKVISCQSAGYDHVDVEEATKRGIYVTKVSGLLSEA--------- 100
+T+ I+E + LK I S GYD D++ K I + +E
Sbjct: 76 MTRSIIEHKSFPRKNLKCIVLCSRGYDGWDLDTLRKHEIRLYNYQDDENEKLIDDLKLHQ 135
Query: 101 ----VAEFALGLLISLMRKIHYADSFIREG---------KWESHTFVW-REFKEV--ETL 144
VA+ AL ++ RK Y RE E F + E + E+
Sbjct: 136 VGNDVADCALWHILEGFRKFSYYQKLSRETGNTLTARAKAAEKSGFAFGHELGNMFAESP 195
Query: 145 YGKEVGIVGMGAIGKAIARRLK-PFGCEIYYWSRHRKEDIEREVNAKYLDLDEL----LE 199
GK+ I+G+G+IGK +A +L+ G EI+Y R + + + K+ LDE L
Sbjct: 196 RGKKCLILGLGSIGKQVAYKLQYGLGMEIHYCKRSEDCTMSQNESWKFHLLDETIYAKLY 255
Query: 200 EVDIVILALPLTKETYHIINEERVKKLE-GKYLVNIGRGALIDEKALVKAIKEGKLKGFA 258
+ +++ LP T +T H+IN + ++ G LVN+GRG ++D +A+ A+ G++
Sbjct: 256 QFHAIVVTLPGTPQTEHLINRKFLEHCNPGLILVNLGRGKILDLRAVSDALVTGRINHLG 315
Query: 259 TDVFEEEPVKEHELFRFKWETVLTPHYAGLGKDVLEDMGFRAVENLLKVLRGEIPED 315
DVF +EP + ++ T +TPH KDV E A+ +L+V+ GE D
Sbjct: 316 LDVFNKEPEIDEKIRSSDRLTSITPHLGSATKDVFEQSCELALTRILRVVSGEAASD 372
>emb|CAB92262.1| (AL356595) putative 2-hydroxyacid dehydrogenase [Streptomyces
coelicolor A3(2)]
Length = 330
Score = 90.9 bits (222), Expect = 2e-17
Identities = 69/259 (26%), Positives = 123/259 (46%), Gaps = 13/259 (5%)
Query: 30 YPSEEELKEIIPELDGIIIAPVTRIT--KDILERAERLKVISCQSAGYDHVDVEEATKRG 87
+P E+ L + + D I++ R+ ++ R RLK++ +D A G
Sbjct: 37 FPDEDALAAALADAD-IVVTLRERVPFPGSLIARLPRLKLLVASGMRNSVIDYAAADAHG 95
Query: 88 IYVTKVSGLLSEAVAEFALGLLISLMRKIHYADSFIREGKWESHTFVWREFKEVETLYGK 147
+ V + + V E L++ L R I + +REG W++ + L+G+
Sbjct: 96 VTVCGTASSSTPPV-ELTWALILGLARGIVQEANGLREGG------PWQQTVGAD-LHGR 147
Query: 148 EVGIVGMGAIGKAIARRLKPFGCEIYYWSRHRKEDIEREVNAKYLDL-DELLEEVDIVIL 206
+G++G+G IG +A+ FG + WS++ ++ EV + +ELL D V +
Sbjct: 148 RLGLLGLGKIGGRVAQVGLAFGMRVSAWSQNLTQERTDEVGVELASSKEELLRTADFVSV 207
Query: 207 ALPLTKETYHIINEERVKKLEGK-YLVNIGRGALIDEKALVKAIKEGKLKGFATDVFEEE 265
L L + T ++ + L+ YLVN R A++D++AL+ A+ EG++ G DVF+ E
Sbjct: 208 HLALGERTRGLLGPAELALLKPTAYLVNTSRAAIVDQEALLAALHEGRIAGAGVDVFDTE 267
Query: 266 PVKEHELFRFKWETVLTPH 284
P+ R + TPH
Sbjct: 268 PLPAGHPMRTAPRLLATPH 286
>emb|CAB56144.1| (AL117669) putative dehydrogenase [Streptomyces coelicolor A3(2)]
Length = 189
Score = 86.2 bits (210), Expect = 5e-16
Identities = 52/178 (29%), Positives = 92/178 (51%), Gaps = 8/178 (4%)
Query: 149 VGIVGMGAIGKAIARRLKPFGCEIYYWSRHRKEDIEREVNAKYLDLDELLEEVDIVILAL 208
+G++ GAI + +A R + FG E++ E R + + D+L+E D +++
Sbjct: 2 LGLLSFGAIARLVAERARAFGVEVWAHDPFVDESEIRAARVRPVSFDDLVEGADHLVVQA 61
Query: 209 PLTKETYHIINEERVKKLE-GKYLVNIGRGALIDEKALVKAIKEGKLKGFATDVFEEEPV 267
PLT +T+H + +++++ LVN RG ++++ AL +A+ G + G A D EEEP
Sbjct: 62 PLTPQTHHTFDRATLRRMKPTAVLVNTARGPIVEDAALYEALTGGWIAGAALDDIEEEPA 121
Query: 268 KEHE------LFRFKWETVLTPHYAGLGKDVLEDMGFRAVENLLKVLRGEIPEDLVNK 319
K+ + LF V+TPH A ++ + + A E ++VL GE VN+
Sbjct: 122 KQRDWRPNNPLFELP-NVVVTPHAAYYSEEAIGTVRTIAAEEAVRVLTGEPARYPVNE 178
>pir||D82435 D-3-phosphoglycerate dehydrogenase-related protein VCA0630
[imported] - Vibrio cholerae (group O1 strain N16961)
>gi|9658044|gb|AAF96531.1| (AE004393)
D-3-phosphoglycerate dehydrogenase-related protein
[Vibrio cholerae]
Length = 323
Score = 77.6 bits (188), Expect = 2e-13
Identities = 76/279 (27%), Positives = 123/279 (43%), Gaps = 12/279 (4%)
Query: 46 IIIAPVTRITKDILERAERLKVISCQSAGYDHVDVEEATKRGIYVTKVSGLLSE-AVAEF 104
++I T IT+++L LK+IS +H+DV + G VT + G+ S A AE
Sbjct: 51 VLIRERTPITENLLAHLPNLKLISQTGKVSNHIDVALCERYG--VTVLEGIGSPVAPAEL 108
Query: 105 ALGLLISLMRKIHYADSFIREGKWESHTFVWREFKEVETLYGKEVGIVGMGAIGKAIARR 164
GL+++ R + + G W+ + + TL G +GI G+G IG+ IA+
Sbjct: 109 CWGLILAASRHLPSYIEQLHAGHWQQNGGLGLG----RTLSGHTLGIWGLGKIGQRIAQF 164
Query: 165 LKPFGCEIYYWSRH--RKEDIEREVNAKYLDLDELLEEVDIVILALPLTKETYHIINEER 222
FG I W R++ +E A D E + D++ L L L T I+ ++
Sbjct: 165 GHVFGMPILVWGSEASRQKALELGYQAA-ADKAEFFAKADVLSLHLRLNDATRGIVTKQD 223
Query: 223 VKKLEGKYL-VNIGRGALIDEKALVKAIKEGKLKGFATDVFEEEPVKEHELFRFKWETVL 281
+ ++ L VN R L++ AL ++ + A DV+E EP + VL
Sbjct: 224 LLAMKPDSLFVNTSRAELVESGALYSVMQTNPTRQAAVDVYENEPALPNNEPLLSLPNVL 283
Query: 282 -TPHYAGLGKDVLEDMGFRAVENLLKVLRGEIPEDLVNK 319
PH + K+ E A EN++K L +K
Sbjct: 284 CAPHLGYVEKNSYEIYFQAAFENVVKFAHSAAKASLSDK 322
>emb|CAB55710.1| (AL117387) possible dehydrogenase [Streptomyces coelicolor A3(2)]
Length = 339
Score = 76.9 bits (186), Expect = 3e-13
Identities = 73/277 (26%), Positives = 121/277 (43%), Gaps = 18/277 (6%)
Query: 49 APVTRITKDILERAERLKVISCQSAGYDHVDVEEATK---RGIYVTKVSGLLSEAVAEFA 105
APV R + L ERL+ + + G +E+ RG+ S VAE+
Sbjct: 63 APVVRA--EHLPGTERLRAV-VYAGGVAATCLEDPAAFAARGVVAANARAANSGPVAEYT 119
Query: 106 LGLLISLMRKIHYADSFIREGKWESHTFVWREFKEVETL--YGKEVGIVGMGAIGKAIAR 163
L +++ +++ E ++ + + F Y + VGIVG +G+A+
Sbjct: 120 LAMILLANKRV-----LAEERRYRASRTLPDHFGAYAGRGNYRQTVGIVGASTVGRAVLG 174
Query: 164 RLKPFGCEIYYWSRHRKEDIEREVNAKYLDLDELLEEVDIVILALPLTKETYHIINEERV 223
L+PF ++ + + + A+ + LDEL+ +V L PLT T I+ R+
Sbjct: 175 LLRPFDLDVLLYDPTLTAEQAAALGARLVPLDELMAHSRVVSLHQPLTPATRGQIDAGRL 234
Query: 224 KKL-EGKYLVNIGRGALIDEKALVKAIKEGKLKGFATDVFEEEPVKEHELFRFKWETVLT 282
+ +G LVN RGA++D+ AL+ ++ G++ DV E EP VLT
Sbjct: 235 ALMPDGATLVNTARGAVVDQDALLAEVRTGRIDA-VLDVTEPEPPDPGSELWALDNVVLT 293
Query: 283 PHYAGLGKDVLEDMGFRAVENLLKVLRGE---IPEDL 316
PH AG L +G + + + G PEDL
Sbjct: 294 PHLAGSLGGELHRIGDAVADEVERFATGRPFAHPEDL 330
>gb|AAK43287.1| D-3-phosphoglycerate dehydrogenase, putative (serA-2) [Sulfolobus
solfataricus]
Length = 300
Score = 69.5 bits (167), Expect = 5e-11
Identities = 74/275 (26%), Positives = 121/275 (43%), Gaps = 25/275 (9%)
Query: 53 RITKDILERAERLKVISCQSAGYDHVDVEEATKRGIYVTKVSGLLSEAVAEFALGLLISL 112
R+ D++ + LKVI SAG D +D + V +G S +VAE A L+++
Sbjct: 41 RVNNDLIGKMPNLKVIQTFSAGVDDLDFSIIPSH-VKVFSNAGAYSLSVAEHAWALILAS 99
Query: 113 MRKIHYADSFIREGKWESHTFVWREFKEVETLYGKEVGIVGMGAIGKAIARRLKP-FGCE 171
+ + I V + K + I+G G IG +AR K F
Sbjct: 100 AKGVGTKKRTI-----------------VYDVSEKTLLILGGGGIGSEVARIGKTAFRNY 142
Query: 172 IYYWSRHRKEDIEREVNAKYLDLDELLEEVDIVILALPLTKETYHIINEERVKKLE-GKY 230
+ SR K+ + L E + E DI++ LPL K+T +++ + +K +
Sbjct: 143 VIGISRSFKKPEWFDERHGMTMLREKIGEADIIVDTLPLNKQTRGLLSYDLLKDIRRNAI 202
Query: 231 LVNIGRGALIDEKALVKAIKEGKLKGFATDVFEEEPVKEHELFRFKWET---VLTPHYAG 287
+VN+GRG +DE+ + K +KE + F TDVF + KE WE T H AG
Sbjct: 203 IVNVGRGETVDEEGIYKLLKERQDVRFGTDVFWRKNGKEDFYNTKLWELDNFTGTLHTAG 262
Query: 288 L--GKDVLEDMGFRAVENLLKVLRGEIPEDLVNKE 320
+ +++ A N+ K + I ++ V +E
Sbjct: 263 AYGNESIMKRAMLIACLNVKKYIDRGIADNEVRRE 297
Database: ./suso.pep
Posted date: Jul 6, 2001 5:57 PM
Number of letters in database: 840,471
Number of sequences in database: 2977
Database: /banques/blast2/nr.pep
Posted date: Dec 14, 2000 12:46 PM
Number of letters in database: 188,266,275
Number of sequences in database: 595,510
Lambda K H
0.319 0.140 0.398
Gapped
Lambda K H
0.270 0.0470 0.230
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 124112671
Number of Sequences: 2977
Number of extensions: 5460297
Number of successful extensions: 17401
Number of sequences better than 1.0e-10: 203
Number of HSP's better than 0.0 without gapping: 26
Number of HSP's successfully gapped in prelim test: 177
Number of HSP's that attempted gapping in prelim test: 16777
Number of HSP's gapped (non-prelim): 209
length of query: 333
length of database: 189,106,746
effective HSP length: 56
effective length of query: 277
effective length of database: 155,591,474
effective search space: 43098838298
effective search space used: 43098838298
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 41 (21.7 bits)
S2: 165 (68.7 bits)