BLASTP 2.0.10 [Aug-26-1999]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= PAB1057 (nrd) DE:ribonucleotide reductase (nrd)
(2122 letters)
Database: ./suso.pep; /banques/blast2/nr.pep
598,487 sequences; 189,106,746 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
pir||B75009 ribonucleotide reductase (nrd) PAB1057 - Pyrococcus ... 4314 0.0
pir||T43215 ribonucleotide reductase (EC 1.17.4.-) class II, ade... 1806 0.0
pir||H71143 probable ribonucleoside-diphosphate reductase - Pyro... 1696 0.0
pdb|1DQ3|A Chain A, Crystal Structure Of An Archaeal Intein-Enco... 644 0.0
pir||D75281 ribonucleoside-diphosphate reductase-related protein... 330 8e-89
gi|11499254 ribonucleotide reductase (nrd) [Archaeoglobus fulgid... 280 1e-73
gb|AAK41209.1| Ribonucleotide reductase (nrd) [Sulfolobus solfat... 251 7e-65
emb|CAC12593.1| (AL445067) ribonucleotide reductase [Thermoplasm... 232 4e-59
pir||T37459 ribonucleotide reductase (EC 1.17.4.-), B12-dependen... 229 2e-58
pir||G69186 ribonucleoside-diphosphate reductase (EC 1.17.4.1) l... 229 2e-58
pir||F72414 ribonucleotide reductase, B12-dependent - Thermotoga... 218 6e-55
gi|9630286 ribunucleotide reductase large subunit [Bacteriophage... 205 4e-51
pir||A70933 probable nrdZ protein - Mycobacterium tuberculosis (... 204 1e-50
gb|AAG19899.1| (AE005073) ribonucleoside reductase large chain; ... 180 2e-43
pir||A69927 ribonucleoside-diphosphate reductase (alph) homolog ... 179 3e-43
dbj|BAB06529.1| (AP001516) ribonucleoside-diphosphate reductase ... 159 3e-37
gb|AAB92484.1| (AF012906) ribonucleotide reductase homolog [Baci... 155 4e-36
gi|6677823 ribonucleotide reductase M1 [Mus musculus] >gi|200765... 148 5e-34
pir||A24050 ribonucleoside-diphosphate reductase (EC 1.17.4.1) c... 148 5e-34
pir||T35125 ribonucleotide reductase - Streptomyces coelicolor >... 148 6e-34
sp|P07742|RIR1_MOUSE RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE M1 CHA... 147 1e-33
sp|O61065|RIR1_CRYPV RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE ... 147 1e-33
gb|AAC12280.2| (AF043243) ribonucleotide reductase R1 subunit [C... 146 2e-33
gi|4506749 ribonucleotide reductase M1 polypeptide [Homo sapiens... 146 3e-33
gi|11435736 ribonucleotide reductase M1 polypeptide [Homo sapiens] 146 3e-33
gb|AAD37491.1| (AF107045) ribonucleotide reductase M1 subunit [H... 146 3e-33
emb|CAA12167.1| (AJ224870) vitamin B12-dependent ribonucleotide ... 145 4e-33
pir||B83502 ribonucleoside reductase, large chain PA1156 [import... 143 2e-32
pir||T51069 ribonucleoside-diphosphate reductase large chain (un... 143 2e-32
pir||T43711 ribonucleoside-diphosphate reductase (EC 1.17.4.1) l... 143 2e-32
gi|9632159 similar to Schizosaccharomyces ribonucleotide reducta... 143 3e-32
emb|CAB77640.1| (AJ390500) ribonucleotide reductase large subuni... 143 3e-32
gb|AAG20478.1| (AE005120) ribonucleoside reductase large chain; ... 141 6e-32
sp|Q9Z6S5|RIR1_CHLPN RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE ALPHA ... 141 8e-32
gb|AAF04636.1|AF099142_4 (AF099142) large subunit of ribonucleot... 141 1e-31
sp|Q03604|RIR1_CAEEL PROBABLE RIBONUCLEOSIDE-DIPHOSPHATE REDUCTA... 140 2e-31
emb|CAB82485.1| (AJ276618) ribonucleotide-diphosphate reductase ... 138 7e-31
gi|9627579 K4L [Variola virus] >gi|417658|sp|P32984|RIR1_VARV RI... 137 1e-30
gi|9790995 I4L; putative [Vaccinia virus] >gi|132610|sp|P20503|R... 137 1e-30
sp|P12848|RIR1_VACCV RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE ... 137 1e-30
sp|O84834|RIR1_CHLTR RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE ALPHA ... 137 1e-30
pir||D71466 probable ribonucleoside reductase, large chain - Chl... 137 1e-30
emb|CAC17629.1| (AJ295338) ribonucleotide-diphosphate reductase ... 137 1e-30
emb|CAB94611.1| (AL359214) ribonucleotide-diphosphate reductase ... 137 2e-30
sp|P50648|RIR1_PLAF4 RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE ... 136 2e-30
pir||A49412 ribonucleoside-diphosphate reductase (EC 1.17.4.1) l... 136 2e-30
sp|P36602|RIR1_SCHPO RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE ... 136 2e-30
gi|9634441 TI4L [Vaccinia virus (strain Tian Tan)] >gi|6969720|g... 136 2e-30
pir||S34807 ribonucleoside-diphosphate reductase (EC 1.17.4.1) l... 136 3e-30
prf||1913428A ribonucleotide reductase:SUBUNIT=large [Schizosacc... 136 3e-30
sp|P79732|RIR1_BRARE RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE M1 CHA... 135 5e-30
pir||F81728 ribonucleoside-diphosphate reductase, alpha chain TC... 135 5e-30
pir||T51813 ribonucleoside-diphosphate reductase (EC 1.17.4.1) l... 134 1e-29
gb|AAD20398.1| (AC007019) putative ribonucleoside-diphosphate re... 134 1e-29
emb|CAB90707.2| (AJ277778) ribonucleotide-diphosphate reductase ... 134 1e-29
gi|9633253 L4L protein [variola minor virus] >gi|7519872|pir||H7... 134 1e-29
sp|O66503|RIR1_AQUAE RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE ALPHA ... 133 2e-29
emb|CAC17631.1| (AJ295339) ribonucleotide-diphosphate reductase ... 133 2e-29
pir||WZVZH4 ribonucleoside-diphosphate reductase (EC 1.17.4.1) l... 132 5e-29
gi|9634360 ORF139 ribonucleotide reductase large subunit (rr1) [... 132 5e-29
gb|AAD33590.1|AF132143_1 (AF132143) ribonucleoside reductase M1 ... 131 7e-29
gb|AAF52913.1| (AE003628) RnrL gene product [Drosophila melanoga... 131 7e-29
gb|AAA48274.1| (M20299) Vaccinia virus matrix 1 protein 130 2e-28
sp|O15909|RIR1_TRYBB RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE ... 129 3e-28
emb|CAA67423.1| (X98924) ribonucleotide reductase [Spodoptera li... 129 4e-28
gb|AAA34569.1| (M58012) ribonucleotide reductase DNA damage-indu... 128 8e-28
pir||WMBY3L ribonucleoside-diphosphate reductase (EC 1.17.4.1) 3... 128 8e-28
gi|6322123 Ribonucleotide reductase (ribonucleoside-diphosphate ... 128 8e-28
emb|CAA71815.1| (Y10861) ribonucleotide reductase [Nicotiana tab... 127 1e-27
pir||B82959 hypothetical protein PA5497 [imported] - Pseudomonas... 126 2e-27
emb|CAA71816.1| (Y10862) ribonucleotide reductase [Nicotiana tab... 123 1e-26
dbj|BAA78761.1| (AB023482) ESTs C27722(C52692),AU058088(S0509) c... 123 2e-26
gi|6320914 ribonucleotide reductase; Rnr1p [Saccharomyces cerevi... 122 4e-26
sp|P50647|RIR1_PLAFG RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE ... 120 1e-25
gb|AAD37499.1|AF111267_1 (AF111267) regulatory protein SCTI [Str... 115 7e-24
pir||E64477 replication factor C homolog - Methanococcus jannasc... 102 4e-20
gb|AAG27192.1|AF275348_12 (AF275348) ribonucleotide reductase, l... 100 2e-19
pir||H72510 probable ribonucleotide reductase APE2062 - Aeropyru... 99 4e-19
gi|9628153 ribonucleotide reductase large subunit [African swine... 99 4e-19
sp|P26685|RIR1_ASFM2 RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE ... 98 1e-18
pir||D75028 h+-transporting ATP synthase, chain alpha (atpa) PAB... 93 3e-17
pir||E82223 ribonucleoside-diphosphate reductase, alpha chain VC... 93 4e-17
dbj|BAB04220.1| (AP001508) ribonucleoside-diphosphate reductase ... 92 5e-17
pir||C81418 ribonucleoside-diphosphate reductase (EC 1.17.4.1) a... 92 8e-17
sp|P55982|RIR1_HELPY RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE ALPHA ... 91 1e-16
sp|Q9ZLF9|RIR1_HELPJ RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE ALPHA ... 91 1e-16
pir||B81101 ribonucleoside-diphosphate reductase, alpha chain NM... 88 1e-15
pir||C82710 ribonucleoside-diphosphate reductase alpha chain XF1... 88 1e-15
gi|9625894 ORF19 (AA1-775) [Human herpesvirus 3] >gi|132612|sp|P... 87 2e-15
sp|P74240|RIR1_SYNY3 RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE ALPHA ... 87 2e-15
sp|P57276|RIR1_BUCAI RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE ALPHA ... 87 2e-15
pir||G81841 ribonucleoside-diphosphate reductase (EC 1.17.4.1) I... 87 3e-15
sp|P37426|RIR1_SALTY RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 1 ALPH... 86 4e-15
emb|CAC12850.1| (AJ250333) DNA polymerase and endonucleases [The... 86 4e-15
pdb|1RLR| Structure Of Ribonucleotide Reductase Protein R1 86 5e-15
sp|Q58815|YE20_METJA HYPOTHETICAL PROTEIN MJ1420 >gi|2127939|pir... 85 8e-15
gb|AAB66912.1| (AF006675) DNA helicase [Rhodothermus marinus] 85 8e-15
emb|CAA74140.1| (Y13813) helicase [Rhodothermus marinus] 85 8e-15
sp|P00452|RIR1_ECOLI RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 1 ALPH... 84 1e-14
pdb|4R1R|A Chain A, Ribonucleotide Reductase R1 Protein With Sub... 84 1e-14
pdb|1R1R|A Chain A, Ribonucleotide Reductase R1 Protein Mutant Y... 84 1e-14
pdb|5R1R|A Chain A, Ribonucleotide Reductase E441a Mutant R1 Pro... 84 1e-14
pdb|6R1R|A Chain A, Ribonucleotide Reductase E441d Mutant R1 Pro... 84 1e-14
pdb|7R1R|A Chain A, Ribonucleotide Reductase E441q Mutant R1 Pro... 84 1e-14
sp|O83972|RIR1_TREPA RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE ALPHA ... 84 1e-14
sp|Q58242|Y832_METJA HYPOTHETICAL PROTEIN MJ0832 >gi|2129243|pir... 84 2e-14
sp|P50642|RIR1_HSVE4 RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE ... 83 3e-14
gi|9629746 21 [Equine herpesvirus 4] >gi|11256458|pir||T42564 ri... 83 3e-14
gi|9629420 ribonucleotide reductase large subunit [human herpesv... 83 4e-14
pir||WMBEB1 ribonucleoside-diphosphate reductase (EC 1.17.4.1) l... 83 4e-14
gb|AAA45805.1| (M18410) ribonucleotide reductase 1 [human herpes... 83 4e-14
emb|CAA30056.1| (X06999) ribonucleotide reductase [Escherichia c... 82 7e-14
pir||B64135 ribonucleoside-diphosphate reductase (EC 1.17.4.1) a... 82 9e-14
sp|P43754|RIR1_HAEIN RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE ALPHA ... 82 9e-14
sp|P39452|RIR3_ECOLI RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 2 ALPH... 82 9e-14
gi|9629309 ribonucleotide reductase large subunit [human herpesv... 80 3e-13
gi|9632790 NDP reductase [Bacteriophage T4] >gi|417656|sp|P32282... 79 5e-13
sp|P09853|RIR1_HSV23 RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE ... 77 2e-12
sp|P50640|RIR1_MYCTU RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE ALPHA ... 77 2e-12
gi|10140905 UL39 product homolog [Gallid herpesvirus 1 (serotype... 77 2e-12
pir||G71213 probable H(+)-transporting ATP synthase subunit A - ... 77 2e-12
emb|CAC18555.1| (AJ245819) DNA polymerase and endonucleases [The... 76 3e-12
pir||F71231 probable replication factor C subunit - Pyrococcus h... 76 5e-12
sp|P30317|DPOL_THELI DNA POLYMERASE (VENT DNA POLYMERASE) [CONTA... 75 1e-11
pir||S34271 ribonucleoside-diphosphate reductase (EC 1.17.4.1) -... 75 1e-11
sp|Q08698|RIR3_SALTY RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 2 ALPH... 75 1e-11
sp|Q55418|DNAB_SYNY3 REPLICATIVE DNA HELICASE >gi|7470824|pir||S... 74 2e-11
gb|AAG30079.1|AF282130_42 (AF282130) UL39 ribonucleotide reducta... 74 2e-11
emb|CAC17731.1| (AJ251716) GyrA protein [Mycobacterium gastri] 74 2e-11
gb|AAA64444.1| (L34407) ribonucleotide reductase R1 subunit [Myc... 74 2e-11
>pir||B75009 ribonucleotide reductase (nrd) PAB1057 - Pyrococcus abyssi (strain
Orsay) >gi|5459026|emb|CAB50512.1| (AJ248288)
ribonucleotide reductase (nrd) [Pyrococcus abyssi]
Length = 2122
Score = 4314 bits (11064), Expect = 0.0
Identities = 2122/2122 (100%), Positives = 2122/2122 (100%)
Query: 1 MPVEKVMKRDGRIVPFDESRIRWAVQRAMWEVGVRDERKLDEVVKNIVKRINELYDGKIP 60
MPVEKVMKRDGRIVPFDESRIRWAVQRAMWEVGVRDERKLDEVVKNIVKRINELYDGKIP
Sbjct: 1 MPVEKVMKRDGRIVPFDESRIRWAVQRAMWEVGVRDERKLDEVVKNIVKRINELYDGKIP 60
Query: 61 HIENIQDIVELELMRAGLFEVAKAYILYRKKKAEIREEKKRILNKKELDEIDKRFSINAL 120
HIENIQDIVELELMRAGLFEVAKAYILYRKKKAEIREEKKRILNKKELDEIDKRFSINAL
Sbjct: 61 HIENIQDIVELELMRAGLFEVAKAYILYRKKKAEIREEKKRILNKKELDEIDKRFSINAL 120
Query: 121 RVLASRYLKRDENGNIIESPRELFERVSILAVIPDLLYDERVFDKDGNYKQDLKRVEYYL 180
RVLASRYLKRDENGNIIESPRELFERVSILAVIPDLLYDERVFDKDGNYKQDLKRVEYYL
Sbjct: 121 RVLASRYLKRDENGNIIESPRELFERVSILAVIPDLLYDERVFDKDGNYKQDLKRVEYYL 180
Query: 181 ENFEKFDGKYSIGKYKLNKYHFERMVNLYRELAEKGKMKVSIDEFLSMLERGEFDKYEKE 240
ENFEKFDGKYSIGKYKLNKYHFERMVNLYRELAEKGKMKVSIDEFLSMLERGEFDKYEKE
Sbjct: 181 ENFEKFDGKYSIGKYKLNKYHFERMVNLYRELAEKGKMKVSIDEFLSMLERGEFDKYEKE 240
Query: 241 IEEYFKLMTNQVFMPNTPALINSGRPLGMLSACFVVPIEDDMESIMKAAHDVAMIQKMGG 300
IEEYFKLMTNQVFMPNTPALINSGRPLGMLSACFVVPIEDDMESIMKAAHDVAMIQKMGG
Sbjct: 241 IEEYFKLMTNQVFMPNTPALINSGRPLGMLSACFVVPIEDDMESIMKAAHDVAMIQKMGG 300
Query: 301 GCIDGNAKIIFENEGEEHLTTMAEMYERYRHLGEFYDENYNRWGIDVSSVPIYVKSFDPE 360
GCIDGNAKIIFENEGEEHLTTMAEMYERYRHLGEFYDENYNRWGIDVSSVPIYVKSFDPE
Sbjct: 301 GCIDGNAKIIFENEGEEHLTTMAEMYERYRHLGEFYDENYNRWGIDVSSVPIYVKSFDPE 360
Query: 361 TRRVVKGRVRAIWKYELGEEIPKYEIRTHKGTKILTSPWHPFFVLTPDFEVIEKRADELK 420
TRRVVKGRVRAIWKYELGEEIPKYEIRTHKGTKILTSPWHPFFVLTPDFEVIEKRADELK
Sbjct: 361 TRRVVKGRVRAIWKYELGEEIPKYEIRTHKGTKILTSPWHPFFVLTPDFEVIEKRADELK 420
Query: 421 VGDILIGGMPDGEDHELIFDYWLAGFIAGNGNLDDSEREYKARELLDGIENGIPPKILRK 480
VGDILIGGMPDGEDHELIFDYWLAGFIAGNGNLDDSEREYKARELLDGIENGIPPKILRK
Sbjct: 421 VGDILIGGMPDGEDHELIFDYWLAGFIAGNGNLDDSEREYKARELLDGIENGIPPKILRK 480
Query: 481 GKNAVLSFITGLFDAEGHVNDKSGIELGMVNKKLIEAVTHYLNSLGIKARMREKRRKNGI 540
GKNAVLSFITGLFDAEGHVNDKSGIELGMVNKKLIEAVTHYLNSLGIKARMREKRRKNGI
Sbjct: 481 GKNAVLSFITGLFDAEGHVNDKSGIELGMVNKKLIEAVTHYLNSLGIKARMREKRRKNGI 540
Query: 541 DYIMHVEEYSSLLRFYELIGKHLQNNEKKEKLEILLHKHNGGAFDLSLNFNAFKEWASRY 600
DYIMHVEEYSSLLRFYELIGKHLQNNEKKEKLEILLHKHNGGAFDLSLNFNAFKEWASRY
Sbjct: 541 DYIMHVEEYSSLLRFYELIGKHLQNNEKKEKLEILLHKHNGGAFDLSLNFNAFKEWASRY 600
Query: 601 GVEFKTNGNQILAIIGNEKVSLGQWHARGHVSKAVLVKMLRKLYEVTKNDEVKEMLHLIE 660
GVEFKTNGNQILAIIGNEKVSLGQWHARGHVSKAVLVKMLRKLYEVTKNDEVKEMLHLIE
Sbjct: 601 GVEFKTNGNQILAIIGNEKVSLGQWHARGHVSKAVLVKMLRKLYEVTKNDEVKEMLHLIE 660
Query: 661 SLEVVKEITITNEPKTFYDLTVDKYQNYLAGENGMIFVHNTGLNFSKLRPEGDIVGTTTG 720
SLEVVKEITITNEPKTFYDLTVDKYQNYLAGENGMIFVHNTGLNFSKLRPEGDIVGTTTG
Sbjct: 661 SLEVVKEITITNEPKTFYDLTVDKYQNYLAGENGMIFVHNTGLNFSKLRPEGDIVGTTTG 720
Query: 721 AACFTGDTRILTEKGLIPIEEIVHETGKKPKVVTHAGLKDIIETYDNGEMEVFRVTTEDG 780
AACFTGDTRILTEKGLIPIEEIVHETGKKPKVVTHAGLKDIIETYDNGEMEVFRVTTEDG
Sbjct: 721 AACFTGDTRILTEKGLIPIEEIVHETGKKPKVVTHAGLKDIIETYDNGEMEVFRVTTEDG 780
Query: 781 YELKVTGDHKFLVFDENGNPTLKPLKELKVGDYVYILAPEWKGGEYVELDTNIELKGKGY 840
YELKVTGDHKFLVFDENGNPTLKPLKELKVGDYVYILAPEWKGGEYVELDTNIELKGKGY
Sbjct: 781 YELKVTGDHKFLVFDENGNPTLKPLKELKVGDYVYILAPEWKGGEYVELDTNIELKGKGY 840
Query: 841 NVNLPSKLDEKLAYLLGIIYADGHIRHYFENGKRKNSKIEIYLHQDETEIKEKVKRYFKE 900
NVNLPSKLDEKLAYLLGIIYADGHIRHYFENGKRKNSKIEIYLHQDETEIKEKVKRYFKE
Sbjct: 841 NVNLPSKLDEKLAYLLGIIYADGHIRHYFENGKRKNSKIEIYLHQDETEIKEKVKRYFKE 900
Query: 901 IFGIEPKEFLKEEQHKVILVIPSTKIVKFLEINGLLKDKSENIRVPEAIFRSRPSVIAAF 960
IFGIEPKEFLKEEQHKVILVIPSTKIVKFLEINGLLKDKSENIRVPEAIFRSRPSVIAAF
Sbjct: 901 IFGIEPKEFLKEEQHKVILVIPSTKIVKFLEINGLLKDKSENIRVPEAIFRSRPSVIAAF 960
Query: 961 LAGFFDGDGSIDQNYRIAFKSISREFIKEAQLLFLALGIVTSIQEYNPPNPNNKTVYTLR 1020
LAGFFDGDGSIDQNYRIAFKSISREFIKEAQLLFLALGIVTSIQEYNPPNPNNKTVYTLR
Sbjct: 961 LAGFFDGDGSIDQNYRIAFKSISREFIKEAQLLFLALGIVTSIQEYNPPNPNNKTVYTLR 1020
Query: 1021 VQTRDMKIKAFNVLKESVKLSKIMKEAISKLEENGKNKKFSFPFNAIYHIKDPKIRAKIQ 1080
VQTRDMKIKAFNVLKESVKLSKIMKEAISKLEENGKNKKFSFPFNAIYHIKDPKIRAKIQ
Sbjct: 1021 VQTRDMKIKAFNVLKESVKLSKIMKEAISKLEENGKNKKFSFPFNAIYHIKDPKIRAKIQ 1080
Query: 1081 RDYKILSYNSKVTHRAFINNILKLKEELGLDDEEVKYFEMLSKLYPTKITKIEPLGKAHV 1140
RDYKILSYNSKVTHRAFINNILKLKEELGLDDEEVKYFEMLSKLYPTKITKIEPLGKAHV
Sbjct: 1081 RDYKILSYNSKVTHRAFINNILKLKEELGLDDEEVKYFEMLSKLYPTKITKIEPLGKAHV 1140
Query: 1141 YDLQVEDVHLLTGNGIYTSNSGPVSFMHLIDAVSDVIKQGGVRRGANMGILEIWHPDIEK 1200
YDLQVEDVHLLTGNGIYTSNSGPVSFMHLIDAVSDVIKQGGVRRGANMGILEIWHPDIEK
Sbjct: 1141 YDLQVEDVHLLTGNGIYTSNSGPVSFMHLIDAVSDVIKQGGVRRGANMGILEIWHPDIEK 1200
Query: 1201 FIHAKEKNIGTNVLSNFNISVGIWEDFWEALKEGKKYPLINPRTGEVVKEIDPKTLFEEL 1260
FIHAKEKNIGTNVLSNFNISVGIWEDFWEALKEGKKYPLINPRTGEVVKEIDPKTLFEEL
Sbjct: 1201 FIHAKEKNIGTNVLSNFNISVGIWEDFWEALKEGKKYPLINPRTGEVVKEIDPKTLFEEL 1260
Query: 1261 AYMAWAKADPGVIFFDIINRRNVLKEAKGGPIRATNPCVVGETRILTPEGYIKAEELFKL 1320
AYMAWAKADPGVIFFDIINRRNVLKEAKGGPIRATNPCVVGETRILTPEGYIKAEELFKL
Sbjct: 1261 AYMAWAKADPGVIFFDIINRRNVLKEAKGGPIRATNPCVVGETRILTPEGYIKAEELFKL 1320
Query: 1321 AKERGKMEAIAVEGIAEGGEPYAYSLEILLPGDKQVKYETVHGNAVEVADPVSVPAYVWK 1380
AKERGKMEAIAVEGIAEGGEPYAYSLEILLPGDKQVKYETVHGNAVEVADPVSVPAYVWK
Sbjct: 1321 AKERGKMEAIAVEGIAEGGEPYAYSLEILLPGDKQVKYETVHGNAVEVADPVSVPAYVWK 1380
Query: 1381 VGMKEVARVRTKEGYEITATLDHKLMTPEGWKEIKDLKPGDKILLPRFEVEEDFGSESIG 1440
VGMKEVARVRTKEGYEITATLDHKLMTPEGWKEIKDLKPGDKILLPRFEVEEDFGSESIG
Sbjct: 1381 VGMKEVARVRTKEGYEITATLDHKLMTPEGWKEIKDLKPGDKILLPRFEVEEDFGSESIG 1440
Query: 1441 EDLAFVLGWFIGDGYLNVKDKRAWFYFNAEKEEEIAWKIREILAKRFEIKAEPHRYGNQI 1500
EDLAFVLGWFIGDGYLNVKDKRAWFYFNAEKEEEIAWKIREILAKRFEIKAEPHRYGNQI
Sbjct: 1441 EDLAFVLGWFIGDGYLNVKDKRAWFYFNAEKEEEIAWKIREILAKRFEIKAEPHRYGNQI 1500
Query: 1501 KLGVRGKAYEWLESIVKTNEKRIPEIVYRLKPNEIASFLRGLFSADGYVDNDMAIRLTSK 1560
KLGVRGKAYEWLESIVKTNEKRIPEIVYRLKPNEIASFLRGLFSADGYVDNDMAIRLTSK
Sbjct: 1501 KLGVRGKAYEWLESIVKTNEKRIPEIVYRLKPNEIASFLRGLFSADGYVDNDMAIRLTSK 1560
Query: 1561 SRELLREVQDLLLLFGILSKIYERPYKREFKYTTKDGEERTYTTEGYYELVIANYSRKIF 1620
SRELLREVQDLLLLFGILSKIYERPYKREFKYTTKDGEERTYTTEGYYELVIANYSRKIF
Sbjct: 1561 SRELLREVQDLLLLFGILSKIYERPYKREFKYTTKDGEERTYTTEGYYELVIANYSRKIF 1620
Query: 1621 AERIGLEGYKMEKLSLEKIKVDEPIVTVESVEILGKKLVYDFTVPEHHMYISNGFMSHNC 1680
AERIGLEGYKMEKLSLEKIKVDEPIVTVESVEILGKKLVYDFTVPEHHMYISNGFMSHNC
Sbjct: 1621 AERIGLEGYKMEKLSLEKIKVDEPIVTVESVEILGKKLVYDFTVPEHHMYISNGFMSHNC 1680
Query: 1681 GEEPLYEYESCNLASINLAKFVKYDENGKPYFDWDEYAYVIQKVAKYLDNSIDVNKFPLP 1740
GEEPLYEYESCNLASINLAKFVKYDENGKPYFDWDEYAYVIQKVAKYLDNSIDVNKFPLP
Sbjct: 1681 GEEPLYEYESCNLASINLAKFVKYDENGKPYFDWDEYAYVIQKVAKYLDNSIDVNKFPLP 1740
Query: 1741 EIDYNTKLTRRIGVGMMGLADALFKLGIPYNSEEGFKFMRKVTEYLTFYAYKYSIEAAKK 1800
EIDYNTKLTRRIGVGMMGLADALFKLGIPYNSEEGFKFMRKVTEYLTFYAYKYSIEAAKK
Sbjct: 1741 EIDYNTKLTRRIGVGMMGLADALFKLGIPYNSEEGFKFMRKVTEYLTFYAYKYSIEAAKK 1800
Query: 1801 RGTFPLYEKTGYPKGELPVEGFYHPEIWNLPWDKLVEEIKKYGVRNAMVTTCPPTGSVSM 1860
RGTFPLYEKTGYPKGELPVEGFYHPEIWNLPWDKLVEEIKKYGVRNAMVTTCPPTGSVSM
Sbjct: 1801 RGTFPLYEKTGYPKGELPVEGFYHPEIWNLPWDKLVEEIKKYGVRNAMVTTCPPTGSVSM 1860
Query: 1861 IADTSSGIEPIFALVYKKSVTVGEFYYVDPVFEAELKRRGLYSEELLKKISDNYGSVQGL 1920
IADTSSGIEPIFALVYKKSVTVGEFYYVDPVFEAELKRRGLYSEELLKKISDNYGSVQGL
Sbjct: 1861 IADTSSGIEPIFALVYKKSVTVGEFYYVDPVFEAELKRRGLYSEELLKKISDNYGSVQGL 1920
Query: 1921 EEIPEDMRRVFVTALDIHWLDHLLAQANIQMWLTDSASKTINMINEATVEDVKAAYLIAH 1980
EEIPEDMRRVFVTALDIHWLDHLLAQANIQMWLTDSASKTINMINEATVEDVKAAYLIAH
Sbjct: 1921 EEIPEDMRRVFVTALDIHWLDHLLAQANIQMWLTDSASKTINMINEATVEDVKAAYLIAH 1980
Query: 1981 FLGCKGVTVYRDGSLSVQVYSVEGEKKRRYKPKPSEYAKKVLLEIVEKEPWIKNFINVDE 2040
FLGCKGVTVYRDGSLSVQVYSVEGEKKRRYKPKPSEYAKKVLLEIVEKEPWIKNFINVDE
Sbjct: 1981 FLGCKGVTVYRDGSLSVQVYSVEGEKKRRYKPKPSEYAKKVLLEIVEKEPWIKNFINVDE 2040
Query: 2041 ILNGKRQELNFSLTGLKRETHEVKKVEVKQQNNKIPEEKIKELLGVVYCPVCYEREGKLV 2100
ILNGKRQELNFSLTGLKRETHEVKKVEVKQQNNKIPEEKIKELLGVVYCPVCYEREGKLV
Sbjct: 2041 ILNGKRQELNFSLTGLKRETHEVKKVEVKQQNNKIPEEKIKELLGVVYCPVCYEREGKLV 2100
Query: 2101 ELRMESGCATCPVCGWSKCVIS 2122
ELRMESGCATCPVCGWSKCVIS
Sbjct: 2101 ELRMESGCATCPVCGWSKCVIS 2122
>pir||T43215 ribonucleotide reductase (EC 1.17.4.-) class II, adenosylcobalamin
dependent - Pyrococcus furiosus
>gi|1688292|gb|AAB36947.1| (U78098) ribonucleotide
reductase [Pyrococcus furiosus]
Length = 1740
Score = 1806 bits (4626), Expect = 0.0
Identities = 951/1420 (66%), Positives = 1088/1420 (75%), Gaps = 100/1420 (7%)
Query: 757 GLKDIIETYDNG-EMEVFRVTTEDGYELKVTGDHKFLVFDENGNPTLKPLKELKVGDYVY 815
G ++I Y+ G ++ + + T G ++ + H F V + K ELK GD +
Sbjct: 367 GKVNVIWKYELGKDVTKYEIITNKGTKILTSPWHPFFVLTPDFKIVEKRADELKEGDILI 426
Query: 816 ILAPEWKGGEYVELDTNIELKGKGYNVNLPSKLDEKLAY---LLGIIYADGHIRHYFENG 872
GG +P D K + L G I DG Y +
Sbjct: 427 -------GG-------------------MPDGEDYKFIFDYWLAGFIAGDGCFDKYHSHV 460
Query: 873 KRKN---SKIEIYLHQDETEIKEKVKRYFKEIFGIEPKEFLKEEQHKVILVIPSTKIVK- 928
K ++ IY ++ ET E + Y ++ FG K ++++++ + I + I
Sbjct: 461 KGHEYIYDRLRIYDYRIET--FEIINDYLEKTFG--RKYSIQKDRNIYYIDIKARNITSH 516
Query: 929 FLEINGLLKDKSENIRVPEAIFRSRPSVIAAFLAGFFDGDGSIDQNYRIAFKSISREFIK 988
+L+ L + +N +P I + + + +F+AG FD +G + I +++ I+
Sbjct: 517 YLK----LLEGIDN-GIPPQILKEGKNAVLSFIAGLFDAEGHVSNKPGIELGMVNKRLIE 571
Query: 989 EAQLLFLALGIVTSIQEYNPPNPNNKTVYTLRVQTRDMKIKAFNVLKESVKLSKIMKEAI 1048
+ ALGI I+E + Y L V+ ++ + ++ ++++ ++ +E +
Sbjct: 572 DVTHYLNALGIKARIRE---KLRKDGIDYVLHVEEYSSLLRFYELIGKNLQ-NEEKREKL 627
Query: 1049 SKLEENGKNKKFSFP--FNAIYH-IKDPKIRAKIQRDYKILSYN------------SKVT 1093
K+ N K F P FNA + + K I N ++V+
Sbjct: 628 EKVLSNHKGGNFGLPLNFNAFKEWASEYGVEFKTNGSQTIAIINDERISLGQWHTRNRVS 687
Query: 1094 HRAFINNILKLKEELGLDDEEVKYFEMLSKLYPTKI-----TKIEPLGKAHVYDLQVEDV 1148
+ + KL E DEEVK ML + ++ T EP YDL VE+
Sbjct: 688 KAVLVKMLRKLYE--ATKDEEVK--RMLHLIEGLEVVRHITTTNEP---RTFYDLTVENY 740
Query: 1149 --HLLTGNG-IYTSN----------------------SGPVSFMHLIDAVSDVIKQGGVR 1183
+L NG I+ N SGPVSFMHLIDAVSDVIKQGGVR
Sbjct: 741 QNYLAGENGMIFVHNTGLNFSKLRPEGDIVGTTTGAASGPVSFMHLIDAVSDVIKQGGVR 800
Query: 1184 RGANMGILEIWHPDIEKFIHAKEKNIGTNVLSNFNISVGIWEDFWEALKEGKKYPLINPR 1243
RGANMGILEIWHPDIEKFIHAKEKNIGTNVLSNFNISVGIWEDFWEALKEGKKYPLINPR
Sbjct: 801 RGANMGILEIWHPDIEKFIHAKEKNIGTNVLSNFNISVGIWEDFWEALKEGKKYPLINPR 860
Query: 1244 TGEVVKEIDPKTLFEELAYMAWAKADPGVIFFDIINRRNVLKEAKGGPIRATNPCVVGET 1303
TGEVVKE+DPKTLFEELAYMAWAKADPGVIFFD+INRRNVLK+AKGGPIRATNPCVVG+T
Sbjct: 861 TGEVVKEVDPKTLFEELAYMAWAKADPGVIFFDVINRRNVLKKAKGGPIRATNPCVVGDT 920
Query: 1304 RILTPEGYIKAEELFKLAKERGKMEAIAVEGIAEGGEPYAYSLEILLPGDKQVKYETVHG 1363
RILTPEGY+KAEE+F LAKERGK EA+AVEGIAE GEPYAYS+EILLPG+++V+YETVHG
Sbjct: 921 RILTPEGYLKAEEIFSLAKERGKKEAVAVEGIAEEGEPYAYSVEILLPGEEKVEYETVHG 980
Query: 1364 NAVEVADPVSVPAYVWKVGMKEVARVRTKEGYEITATLDHKLMTPEGWKEIKDLKPGDKI 1423
+ VADPV+VPAYVWKVG K+VARV+TKEGYEITATLDHKLMTPEGWKE+ LK GDKI
Sbjct: 981 KVLAVADPVAVPAYVWKVGRKKVARVKTKEGYEITATLDHKLMTPEGWKEVGKLKEGDKI 1040
Query: 1424 LLPRFEVEEDFGSESIGEDLAFVLGWFIGDGYLNVKDKRAWFYFNAEKEEEIAWKIREIL 1483
LLPRFEVEE+FGSESIGEDLAFVLGWFIGDGYLNV DKRAWFYFNAEKEEEIA +IR+IL
Sbjct: 1041 LLPRFEVEEEFGSESIGEDLAFVLGWFIGDGYLNVNDKRAWFYFNAEKEEEIAVRIRDIL 1100
Query: 1484 AKRFEIKAEPHRYGNQIKLGVRGKAYEWLESIVKTNEKRIPEIVYRLKPNEIASFLRGLF 1543
K F IKAE HRYGNQIKLGVRG+AY WLE+IVK NEKRIPEIVYRLKP EIA+FLRGLF
Sbjct: 1101 VKHFGIKAELHRYGNQIKLGVRGEAYRWLENIVKNNEKRIPEIVYRLKPREIAAFLRGLF 1160
Query: 1544 SADGYVDNDMAIRLTSKSRELLREVQDLLLLFGILSKIYERPYKREFKYTTKDGEERTYT 1603
SADGYVD DMAIRLTSKSRELLREVQDLLLLFGILSKIYE+PY+ EF YTTK+GEER Y
Sbjct: 1161 SADGYVDKDMAIRLTSKSRELLREVQDLLLLFGILSKIYEKPYESEFHYTTKNGEERIYR 1220
Query: 1604 TEGYYELVIANYSRKIFAERIGLEGYKMEKLSLEKIKVDEPIVTVESVEILGKKLVYDFT 1663
++GYYELVI NYSRK+FAE+IGLEGYKMEKLSL+K KVD+PIVTVESVE+LG+++VYDFT
Sbjct: 1221 SKGYYELVITNYSRKLFAEKIGLEGYKMEKLSLKKTKVDQPIVTVESVEVLGEEIVYDFT 1280
Query: 1664 VPEHHMYISNGFMSHNCGEEPLYEYESCNLASINLAKFVKYDENGKPYFDWDEYAYVIQK 1723
VP +HMYISNGFMSHNCGEEPLYEYESCNLASINLAKFVKYDENGKPYFDWDEYAYVIQK
Sbjct: 1281 VPNYHMYISNGFMSHNCGEEPLYEYESCNLASINLAKFVKYDENGKPYFDWDEYAYVIQK 1340
Query: 1724 VAKYLDNSIDVNKFPLPEIDYNTKLTRRIGVGMMGLADALFKLGIPYNSEEGFKFMRKVT 1783
VAKYLDNSIDVNKFPLPEIDYNTKLTRRIGVGMMGLADALFKLGIPYNSEEGFKFMRKVT
Sbjct: 1341 VAKYLDNSIDVNKFPLPEIDYNTKLTRRIGVGMMGLADALFKLGIPYNSEEGFKFMRKVT 1400
Query: 1784 EYLTFYAYKYSIEAAKKRGTFPLYEKTGYPKGELPVEGFYHPEIWNLPWDKLVEEIKKYG 1843
EYLTFYAYKYS+EAAKKRGTFPLY+KT YP+G+LPVEGFYHPEIWNLPWDKLVEEIKKYG
Sbjct: 1401 EYLTFYAYKYSVEAAKKRGTFPLYDKTEYPEGKLPVEGFYHPEIWNLPWDKLVEEIKKYG 1460
Query: 1844 VRNAMVTTCPPTGSVSMIADTSSGIEPIFALVYKKSVTVGEFYYVDPVFEAELKRRGLYS 1903
+RNAMVTTCPPTGSVSMIADTSSGIEP++ALVYKKSVTVGEFYYVDPVFE ELK+RGLYS
Sbjct: 1461 LRNAMVTTCPPTGSVSMIADTSSGIEPVYALVYKKSVTVGEFYYVDPVFEEELKKRGLYS 1520
Query: 1904 EELLKKISDNYGSVQGLEEIPEDMRRVFVTALDIHWLDHLLAQANIQMWLTDSASKTINM 1963
EELLKKISDNYGSVQGLEEIPEDM+RVFVTALDIHWLDH++AQA+IQMWLTDSASKTINM
Sbjct: 1521 EELLKKISDNYGSVQGLEEIPEDMQRVFVTALDIHWLDHIIAQASIQMWLTDSASKTINM 1580
Query: 1964 INEATVEDVKAAYLIAHFLGCKGVTVYRDGSLSVQVYSVEGE-KKRRYKPKPSEYAKKVL 2022
INEATVEDVKAAYLIA FLGCKGVTVYRDGSLSVQVYSVEGE KKRR+KPKPSEYAKK+L
Sbjct: 1581 INEATVEDVKAAYLIARFLGCKGVTVYRDGSLSVQVYSVEGEKKKRRFKPKPSEYAKKIL 1640
Query: 2023 LEIVEKEPWIKNFINVDEILNGKRQELNFSLTGLKRETHEVKKVEVKQQNNKIPEEKIKE 2082
LEIVEKEPWIKNFINVDEILNGK+++L FSL +V E + + IPEEKI+E
Sbjct: 1641 LEIVEKEPWIKNFINVDEILNGKKEQLLFSLRPANESKLKVPGREEEVRPGNIPEEKIRE 1700
Query: 2083 LLGVVYCPVCYEREGKLVELRMESGCATCPVCGWSKCVIS 2122
LLGVVYCPVCYE+EGKLVEL+MESGCATCPVCGWSKCVIS
Sbjct: 1701 LLGVVYCPVCYEKEGKLVELKMESGCATCPVCGWSKCVIS 1740
Score = 1152 bits (2948), Expect = 0.0
Identities = 580/777 (74%), Positives = 641/777 (81%), Gaps = 55/777 (7%)
Query: 1 MPVEKVMKRDGRIVPFDESRIRWAVQRAMWEVGVRDERKLDEVVKNIVKRINELYDGKIP 60
M VEKVMKRDGRIVPFDESRIRWAVQRAMWEVG+RDE+KLDEVVK+IV+RINELYDGKIP
Sbjct: 1 MAVEKVMKRDGRIVPFDESRIRWAVQRAMWEVGIRDEKKLDEVVKSIVQRINELYDGKIP 60
Query: 61 HIENIQDIVELELMRAGLFEVAKAYILYRKKKAEIREEKKRILNKKELDEIDKRFSINAL 120
HIENIQDIVELELMRAGLFEVAKAYILYRKKKAEIREEKKRILNKKELDEIDKRFSINAL
Sbjct: 61 HIENIQDIVELELMRAGLFEVAKAYILYRKKKAEIREEKKRILNKKELDEIDKRFSINAL 120
Query: 121 RVLASRYLKRDENGNIIESPRELFERVSILAVIPDLLYDERVFDKDGNYKQDLKRVEYYL 180
RVLASRYLK+DENGNI+ESPRELFERV+ILAVIPDLLYDERVFDK+GNY QDLKRVEYYL
Sbjct: 121 RVLASRYLKKDENGNIVESPRELFERVAILAVIPDLLYDERVFDKNGNYSQDLKRVEYYL 180
Query: 181 ENFEKFDGKYSIGKYKLNKYHFERMVNLYRELAEKGKMKVSIDEFLSMLERGEFDKYEKE 240
E+FE+FD KYSIGKYKLNKYHFERMVNLY+ELAE+GKMKVSIDEFL+MLE+GEF++YEKE
Sbjct: 181 EHFEEFDRKYSIGKYKLNKYHFERMVNLYKELAEQGKMKVSIDEFLAMLEKGEFNEYEKE 240
Query: 241 IEEYFKLMTNQVFMPNTPALINSGRPLGMLSACFVVPIEDDMESIMKAAHDVAMIQKMGG 300
I EYF+LMTNQ+FMPNTPALINSGRPLGMLSACFVVPIEDDMESIMKAAHDVAMIQKMGG
Sbjct: 241 INEYFRLMTNQIFMPNTPALINSGRPLGMLSACFVVPIEDDMESIMKAAHDVAMIQKMGG 300
Query: 301 GCIDGNAKIIFENEGEEHLTTMAEMYERYRHLGEFYDENYNRWGIDVSSVPIYVKSFDPE 360
GCIDG AKIIFENEGEEHLTTM EMYERY+HLGEFYDE YNRWGIDVS+VPIYVKSFDPE
Sbjct: 301 GCIDGKAKIIFENEGEEHLTTMEEMYERYKHLGEFYDEEYNRWGIDVSNVPIYVKSFDPE 360
Query: 361 TRRVVKGRVRAIWKYELGEEIPKYEIRTHKGTKILTSPWHPFFVLTPDFEVIEKRADELK 420
++RVVKG+V IWKYELG+++ KYEI T+KGTKILTSPWHPFFVLTPDF+++EKRADELK
Sbjct: 361 SKRVVKGKVNVIWKYELGKDVTKYEIITNKGTKILTSPWHPFFVLTPDFKIVEKRADELK 420
Query: 421 VGDILIGGMPDGEDHELIFDYWLAGFIAGNGNLDDSEREYKARELL-------------- 466
GDILIGGMPDGED++ IFDYWLAGFIAG+G D K E +
Sbjct: 421 EGDILIGGMPDGEDYKFIFDYWLAGFIAGDGCFDKYHSHVKGHEYIYDRLRIYDYRIETF 480
Query: 467 ----DGIENGIPPKI-LRKGKNAVLSFITGLFDAEGHVNDKSGIELGMVNK--------- 512
D +E K ++K +N I ++ GI+ G+ +
Sbjct: 481 EIINDYLEKTFGRKYSIQKDRNIYYIDIKARNITSHYLKLLEGIDNGIPPQILKEGKNAV 540
Query: 513 -----KLIEAVTHYLNSLG----------------------IKARMREKRRKNGIDYIMH 545
L +A H N G IKAR+REK RK+GIDY++H
Sbjct: 541 LSFIAGLFDAEGHVSNKPGIELGMVNKRLIEDVTHYLNALGIKARIREKLRKDGIDYVLH 600
Query: 546 VEEYSSLLRFYELIGKHLQNNEKKEKLEILLHKHNGGAFDLSLNFNAFKEWASRYGVEFK 605
VEEYSSLLRFYELIGK+LQN EK+EKLE +L H GG F L LNFNAFKEWAS YGVEFK
Sbjct: 601 VEEYSSLLRFYELIGKNLQNEEKREKLEKVLSNHKGGNFGLPLNFNAFKEWASEYGVEFK 660
Query: 606 TNGNQILAIIGNEKVSLGQWHARGHVSKAVLVKMLRKLYEVTKNDEVKEMLHLIESLEVV 665
TNG+Q +AII +E++SLGQWH R VSKAVLVKMLRKLYE TK++EVK MLHLIE LEVV
Sbjct: 661 TNGSQTIAIINDERISLGQWHTRNRVSKAVLVKMLRKLYEATKDEEVKRMLHLIEGLEVV 720
Query: 666 KEITITNEPKTFYDLTVDKYQNYLAGENGMIFVHNTGLNFSKLRPEGDIVGTTTGAA 722
+ IT TNEP+TFYDLTV+ YQNYLAGENGMIFVHNTGLNFSKLRPEGDIVGTTTGAA
Sbjct: 721 RHITTTNEPRTFYDLTVENYQNYLAGENGMIFVHNTGLNFSKLRPEGDIVGTTTGAA 777
>pir||H71143 probable ribonucleoside-diphosphate reductase - Pyrococcus horikoshii
>gi|3256754|dbj|BAA29437.1| (AP000002) 1291aa long
hypothetical ribonucleoside-diphosphate reductase
[Pyrococcus horikoshii]
Length = 1291
Score = 1696 bits (4343), Expect = 0.0
Identities = 823/967 (85%), Positives = 894/967 (92%), Gaps = 11/967 (1%)
Query: 1161 SGPVSFMHLIDAVSDVIKQGGVRRGANMGILEIWHPDIEKFIHAKEKNIGTNVLSNFNIS 1220
SGPVSFMHLIDAVSDVIKQGGVRRGANMGILEIWHPDIEKFIHAKEKNIGTNVLSNFNIS
Sbjct: 331 SGPVSFMHLIDAVSDVIKQGGVRRGANMGILEIWHPDIEKFIHAKEKNIGTNVLSNFNIS 390
Query: 1221 VGIWEDFWEALKEGKKYPLINPRTGEVVKEIDPKTLFEELAYMAWAKADPGVIFFDIINR 1280
VGIWEDF EALKEGKKYPLINPRTGEVV+E+DPK+LFEELAYMAWAKADPGVIFFDIINR
Sbjct: 391 VGIWEDFLEALKEGKKYPLINPRTGEVVREVDPKSLFEELAYMAWAKADPGVIFFDIINR 450
Query: 1281 RNVLKEAKGGPIRATNPCVVGETRILTPEGYIKAEELFKLAKERGKME-AIAVEGIAEGG 1339
RNVLKEAKGGPIRATNPCVVG+TRILTPEGY+K E+LF++AKER E +AVEGIAEGG
Sbjct: 451 RNVLKEAKGGPIRATNPCVVGDTRILTPEGYLKIEDLFRMAKERNNGEKVVAVEGIAEGG 510
Query: 1340 EPYAYSLEILLPGD--KQVKYETVHGNAVEVADPVSVPAYVWKVGMKEVARVRTKEGYEI 1397
E +AY + ILLP + K+V YETVHG + +ADP+ V AYVWKVG K+VAR++TKEGYEI
Sbjct: 511 EEFAYPVAILLPNEEEKEVIYETVHGKQLAIADPIEVKAYVWKVGKKKVARIKTKEGYEI 570
Query: 1398 TATLDHKLMTPEGWKEIKDLKPGDKILLPRFEVEEDFGSESIGEDLAFVLGWFIGDGYLN 1457
ATLDHK+MT +GWK ++DLK GD I+LPRFEVE++FGSESIGEDLAFVLGW IGDGY+N
Sbjct: 571 IATLDHKIMTKDGWKAVEDLKEGDLIVLPRFEVEDNFGSESIGEDLAFVLGWLIGDGYIN 630
Query: 1458 VKDKRAWFYFNAEKEEEIAWKIREILAKRFEIKAEPHRYGNQIKLGVRGKAYEWLESIVK 1517
DKR WFYFNAEKEEEIA KI EIL KRF KAEPHRYG++IKLGVRG+AY++ E IVK
Sbjct: 631 TDDKRVWFYFNAEKEEEIAQKISEILKKRFNSKAEPHRYGSEIKLGVRGEAYKFFEKIVK 690
Query: 1518 TNEKRIPEIVYRLKPNEIASFLRGLFSADGYVDNDMAIRLTSKSRELLREVQDLLLLFGI 1577
TN+KR+PEIVY LKPNEI +FLRGLF+ADGYVDND AIRLTSKSRELLR+VQDLLLLFGI
Sbjct: 691 TNDKRVPEIVYHLKPNEIRAFLRGLFTADGYVDNDGAIRLTSKSRELLRDVQDLLLLFGI 750
Query: 1578 LSKIYERPYKREFKYTTKDGEERTYTTEGYYELVIANYSRKIFAERIGLEGYKMEKLSLE 1637
+SKIYERPYK F+YTTK+GE++ YT +GYYELVIANYSRK+FAE+IG EG K +K+ L
Sbjct: 751 ISKIYERPYKGTFEYTTKEGEKKVYTAQGYYELVIANYSRKLFAEKIGFEGEKQKKIKLN 810
Query: 1638 KIKVDEPIVTVESVEILGKKLVYDFTVPEHHMYISNGFMSHNCGEEPLYEYESCNLASIN 1697
K K+DEP VESVEI+G+++VYD TVP H YISNGF+SHNCGEEPLYEYESCNLASIN
Sbjct: 811 KTKIDEPYARVESVEIIGEEIVYDLTVPGIHSYISNGFISHNCGEEPLYEYESCNLASIN 870
Query: 1698 LAKFVKYDENGKPYFDWDEYAYVIQKVAKYLDNSIDVNKFPLPEIDYNTKLTRRIGVGMM 1757
LAKFVKYDENGKPYFDWDEYAYVIQKV KYLDN+IDVNKFPLPEID+NTKLTRRIGVGMM
Sbjct: 871 LAKFVKYDENGKPYFDWDEYAYVIQKVTKYLDNAIDVNKFPLPEIDHNTKLTRRIGVGMM 930
Query: 1758 GLADALFKLGIPYNSEEGFKFMRKVTEYLTFYAYKYSIEAAKKRGTFPLYEKTGYPKGEL 1817
GLADALFKLGIPYNSEEGFKFMRKVTEYLTFYAYKYS+EAAK+RGTFPLYEKT YPKG+L
Sbjct: 931 GLADALFKLGIPYNSEEGFKFMRKVTEYLTFYAYKYSVEAAKRRGTFPLYEKTEYPKGKL 990
Query: 1818 PVEGFYHPEIWNLPWDKLVEEIKKYGVRNAMVTTCPPTGSVSMIADTSSGIEPIFALVYK 1877
PVEGFYHPEIWNLPWDKLVEEIKKYG+RNAMVTTCPPTGSVSMIADTSSGIEPI+ALVYK
Sbjct: 991 PVEGFYHPEIWNLPWDKLVEEIKKYGLRNAMVTTCPPTGSVSMIADTSSGIEPIYALVYK 1050
Query: 1878 KSVTVGEFYYVDPVFEAELKRRGLYSEELLKKISDNYGSVQGLEEIPEDMRRVFVTALDI 1937
KSVTVGEFYYVDPVFEAELK+RGLYSEELLKKISDNYGS+QGLEEIPEDM+RVFVTALDI
Sbjct: 1051 KSVTVGEFYYVDPVFEAELKKRGLYSEELLKKISDNYGSIQGLEEIPEDMKRVFVTALDI 1110
Query: 1938 HWLDHLLAQANIQMWLTDSASKTINMINEATVEDVKAAYLIAHFLGCKGVTVYRDGSLSV 1997
HWLDHLLAQA+IQMWLTDSASKTINMINEATVEDVKAAYLIAHFLGCKGVTVYRDGSLSV
Sbjct: 1111 HWLDHLLAQASIQMWLTDSASKTINMINEATVEDVKAAYLIAHFLGCKGVTVYRDGSLSV 1170
Query: 1998 QVYSVEGE-KKRRYKPKPSEYAKKVLLEIVEKEPWIKNFINVDEILNGKRQ-ELNFSLTG 2055
QVYSVEGE KKR+YKPKPSEYAKKV LEIVEKEPWIKNFINVDEILNGKR+ L FSL+
Sbjct: 1171 QVYSVEGEKKKRKYKPKPSEYAKKVFLEIVEKEPWIKNFINVDEILNGKRESNLTFSLS- 1229
Query: 2056 LKRETHEVKKVEVKQQNNKIPEEKIKELLGVVYCPVCYEREGKLVELRMESGCATCPVCG 2115
+K+E H+ E Q+N IPEEKIKELLGVVYCPVCYEREGKLVELRMESGCATCPVCG
Sbjct: 1230 IKKE-HQ----EKPQENKGIPEEKIKELLGVVYCPVCYEREGKLVELRMESGCATCPVCG 1284
Query: 2116 WSKCVIS 2122
WSKCVIS
Sbjct: 1285 WSKCVIS 1291
Score = 577 bits (1471), Expect = e-163
Identities = 285/301 (94%), Positives = 296/301 (97%)
Query: 1 MPVEKVMKRDGRIVPFDESRIRWAVQRAMWEVGVRDERKLDEVVKNIVKRINELYDGKIP 60
M VEKVMKRDGRIVPFDESRIRWAVQRAMWEVGVRDE+KLDEVVK IV+RINELYDGKIP
Sbjct: 8 MVVEKVMKRDGRIVPFDESRIRWAVQRAMWEVGVRDEKKLDEVVKAIVQRINELYDGKIP 67
Query: 61 HIENIQDIVELELMRAGLFEVAKAYILYRKKKAEIREEKKRILNKKELDEIDKRFSINAL 120
HIENIQDIVELELMRAGLFEVAKAYILYRKKKAEIREEKKRILNKKELDEIDKRFSINAL
Sbjct: 68 HIENIQDIVELELMRAGLFEVAKAYILYRKKKAEIREEKKRILNKKELDEIDKRFSINAL 127
Query: 121 RVLASRYLKRDENGNIIESPRELFERVSILAVIPDLLYDERVFDKDGNYKQDLKRVEYYL 180
RVLASRYLKRDENGNIIESPRELFERV+ILAVIPDLLYDERVFDKDGNY QDLKRVEYYL
Sbjct: 128 RVLASRYLKRDENGNIIESPRELFERVAILAVIPDLLYDERVFDKDGNYSQDLKRVEYYL 187
Query: 181 ENFEKFDGKYSIGKYKLNKYHFERMVNLYRELAEKGKMKVSIDEFLSMLERGEFDKYEKE 240
E+FE+FDGKYSIGKYKLNKYHFERMVNLY+ELAEKGKMKVSIDEFL MLERGEF+KYEKE
Sbjct: 188 EHFEEFDGKYSIGKYKLNKYHFERMVNLYKELAEKGKMKVSIDEFLGMLERGEFNKYEKE 247
Query: 241 IEEYFKLMTNQVFMPNTPALINSGRPLGMLSACFVVPIEDDMESIMKAAHDVAMIQKMGG 300
I+EYF+LMTNQ+FMPNTPALINSGRPLGMLSACFVVPIEDDMESIMKAAHDVA+IQK GG
Sbjct: 248 IDEYFRLMTNQIFMPNTPALINSGRPLGMLSACFVVPIEDDMESIMKAAHDVALIQKAGG 307
Query: 301 G 301
G
Sbjct: 308 G 308
Score = 94.0 bits (230), Expect = 2e-17
Identities = 102/388 (26%), Positives = 161/388 (41%), Gaps = 92/388 (23%)
Query: 663 EVVKEITITNEPKTFYDLTVDKYQNYLAGENGMIFVHNTGLNFSKLRPEGDIVGTTTGAA 722
EVV+E+ +PK+ ++ Y + + G+IF +G + T
Sbjct: 416 EVVREV----DPKSLFEELA--YMAWAKADPGVIFFDIINRRNVLKEAKGGPIRATN--P 467
Query: 723 CFTGDTRILTEKGLIPIEEIVH---ETGKKPKVVTHAGLKD------------------- 760
C GDTRILT +G + IE++ E KVV G+ +
Sbjct: 468 CVVGDTRILTPEGYLKIEDLFRMAKERNNGEKVVAVEGIAEGGEEFAYPVAILLPNEEEK 527
Query: 761 --IIETYDN------------------GEMEVFRVTTEDGYELKVTGDHKFLVFDENGNP 800
I ET G+ +V R+ T++GYE+ T DHK + D
Sbjct: 528 EVIYETVHGKQLAIADPIEVKAYVWKVGKKKVARIKTKEGYEIIATLDHKIMTKDG---- 583
Query: 801 TLKPLKELKVGDYVYILAPEWKGGEYVELDTNIELKGKGYNVNLPSKLDEKLAYLLGIIY 860
K +++LK GD + + P + E++ N + G E LA++LG +
Sbjct: 584 -WKAVEDLKEGDLIVL--PRF------EVEDNFGSESIG----------EDLAFVLGWLI 624
Query: 861 ADGHIRHYFENGKRKNSKIEIYLHQD-ETEIKEKVKRYFKEIFG--IEPKEFLKEEQHKV 917
DG+I + ++ Y + + E EI +K+ K+ F EP + E + V
Sbjct: 625 GDGYIN-------TDDKRVWFYFNAEKEEEIAQKISEILKKRFNSKAEPHRYGSEIKLGV 677
Query: 918 ILVIPSTKIVKFLEINGLLKDKSENIRVPEAIFRSRPSVIAAFLAGFFDGDGSIDQNYRI 977
+ KF E DK RVPE ++ +P+ I AFL G F DG +D + I
Sbjct: 678 -----RGEAYKFFEKIVKTNDK----RVPEIVYHLKPNEIRAFLRGLFTADGYVDNDGAI 728
Query: 978 AFKSISREFIKEAQLLFLALGIVTSIQE 1005
S SRE +++ Q L L GI++ I E
Sbjct: 729 RLTSKSRELLRDVQDLLLLFGIISKIYE 756
>pdb|1DQ3|A Chain A, Crystal Structure Of An Archaeal Intein-Encoded Homing
Endonuclease Pi-Pfui
Length = 454
Score = 644 bits (1642), Expect = 0.0
Identities = 319/454 (70%), Positives = 361/454 (79%), Gaps = 55/454 (12%)
Query: 302 CIDGNAKIIFENEGEEHLTTMAEMYERYRHLGEFYDENYNRWGIDVSSVPIYVKSFDPET 361
CIDG AKIIFENEGEEHLTTM EMYERY+HLGEFYDE YNRWGIDVS+VPIYVKSFDPE+
Sbjct: 1 CIDGKAKIIFENEGEEHLTTMEEMYERYKHLGEFYDEEYNRWGIDVSNVPIYVKSFDPES 60
Query: 362 RRVVKGRVRAIWKYELGEEIPKYEIRTHKGTKILTSPWHPFFVLTPDFEVIEKRADELKV 421
+RVVKG+V IWKYELG+++ KYEI T+KGTKILTSPWHPFFVLTPDF+++EKRADELK
Sbjct: 61 KRVVKGKVNVIWKYELGKDVTKYEIITNKGTKILTSPWHPFFVLTPDFKIVEKRADELKE 120
Query: 422 GDILIGGMPDGEDHELIFDYWLAGFIAGNGNLD-------------DSEREY-------- 460
GDILIGGMPDGED++ IFDYWLAGFIAG+G D D R Y
Sbjct: 121 GDILIGGMPDGEDYKFIFDYWLAGFIAGDGCFDKYHSHVKGHEYIYDRLRIYDYRIETFE 180
Query: 461 ---------------------------KAR-------ELLDGIENGIPPKILRKGKNAVL 486
KAR +LL+GI+NGIPP+IL++GKNAVL
Sbjct: 181 IINDYLEKTFGRKYSIQKDRNIYYIDIKARNITSHYLKLLEGIDNGIPPQILKEGKNAVL 240
Query: 487 SFITGLFDAEGHVNDKSGIELGMVNKKLIEAVTHYLNSLGIKARMREKRRKNGIDYIMHV 546
SFI GLFDAEGHV++K GIELGMVNK+LIE VTHYLN+LGIKAR+REK RK+GIDY++HV
Sbjct: 241 SFIAGLFDAEGHVSNKPGIELGMVNKRLIEDVTHYLNALGIKARIREKLRKDGIDYVLHV 300
Query: 547 EEYSSLLRFYELIGKHLQNNEKKEKLEILLHKHNGGAFDLSLNFNAFKEWASRYGVEFKT 606
EEYSSLLRFYELIGK+LQN EK+EKLE +L H GG F L LNFNAFKEWAS YGVEFKT
Sbjct: 301 EEYSSLLRFYELIGKNLQNEEKREKLEKVLSNHKGGNFGLPLNFNAFKEWASEYGVEFKT 360
Query: 607 NGNQILAIIGNEKVSLGQWHARGHVSKAVLVKMLRKLYEVTKNDEVKEMLHLIESLEVVK 666
NG+Q +AII +E++SLGQWH R VSKAVLVKMLRKLYE TK++EVK MLHLIE LEVV+
Sbjct: 361 NGSQTIAIINDERISLGQWHTRNRVSKAVLVKMLRKLYEATKDEEVKRMLHLIEGLEVVR 420
Query: 667 EITITNEPKTFYDLTVDKYQNYLAGENGMIFVHN 700
IT TNEP+TFYDLTV+ YQNYLAGENGMIFVHN
Sbjct: 421 HITTTNEPRTFYDLTVENYQNYLAGENGMIFVHN 454
>pir||D75281 ribonucleoside-diphosphate reductase-related protein - Deinococcus
radiodurans (strain R1)
>gi|6460188|gb|AAF11919.1|AE002068_2 (AE002068)
ribonucleoside-diphosphate reductase-related protein
[Deinococcus radiodurans]
Length = 1418
Score = 330 bits (838), Expect = 8e-89
Identities = 273/933 (29%), Positives = 430/933 (45%), Gaps = 162/933 (17%)
Query: 1160 NSGPVSFMHLIDA-VSDVIKQGGVRRGANMGILEIWHPDIEKFIHAKE--KNIGTNVLSN 1216
+SGP++ + + A V V++QGG RRGA M + I HPD+ F+ AK+ + +S
Sbjct: 352 DSGPINTLRYVYAPVLRVVRQGGTRRGAGMATISIGHPDVLDFLTAKDLDREAAEGDIST 411
Query: 1217 FNISVGIWEDFWEALKE------------GKKYPLINPRTGEVV---------------- 1248
FNIS+ + FW+ L+ GK +P+ P+ GE
Sbjct: 412 FNISILVDTKFWDTLQADGVWTIDAQDVPGKYFPV--PQEGEYAGTFPELPTRAEDGAKG 469
Query: 1249 -----KEIDPKTLFEELAYMAWAKADPGVIFFDIINRRNVLKE-AKGGPIRATNPCVVGE 1302
I + L++++A AW+ +PG+IF D +N + LK + IR+TNPCV +
Sbjct: 470 VPVYGSGIPARWLWDQIAQHAWSTGEPGLIFNDRVNEYSALKNLGERYEIRSTNPCVTAD 529
Query: 1303 TRILTPEGYIKAEELFKLAKERGKMEAIAVEGIAEGGEPYAYSLEILLPGDKQVKYETVH 1362
T + T G + ++L GK V G
Sbjct: 530 TWVSTAFGARQVQDLI------GKDFCATVNG---------------------------- 555
Query: 1363 GNAVEVADPVSVPAYVWKVGMKEVARVRTKEGYEITATLDHKLMT---------PEGWKE 1413
+ S W G+K V +V T+ GYE+ T +H+L+ W E
Sbjct: 556 -------ESFSARGGFWLTGVKSVLKVTTRRGYELRLTGNHQLLKVTHQTRKVQQTAWVE 608
Query: 1414 IKDLKPGDKILLPRFEVEEDF-GSESIGEDLAFVLGWFIGDGYLNVKDKR--AWFYFNAE 1470
L GD+I+L + + G+ + E ++LG IGDG R A F E
Sbjct: 609 TATLAAGDRIMLNDHRTVKPWAGAGNFSE--GWLLGSLIGDGTFLTDKARPMAALGFWGE 666
Query: 1471 KEEEIAWKIREILAKRFEIKA---EPHRYGNQIKLGVRGKAYEWLESIVKTNEKRIPEIV 1527
+ + A + L+K +K +++L A + V K + + V
Sbjct: 667 ERQAQADSAQARLSKLGAVKKLWRSNDEQRQRVRLSSEALAELGAKYGVVHGHKTLTDKV 726
Query: 1528 YRLKPNEIASFLRGLFSADGYVDND----MAIRLTSKSRELLREVQDLLLLFGILSKIY- 1582
+ L+GLF ADG V +++RL LL+ Q +L GI+S +Y
Sbjct: 727 EQGGYEFYRGVLQGLFDADGSVQGTQSKGVSVRLAQSDLSLLKRAQRMLSRLGIMSSLYA 786
Query: 1583 ERPYKREFKYTTKDGEERTYTTEGYYELVIANYSRKIFAERIGLE-----GYKMEKLSLE 1637
ER G Y T+ +EL+I+ + +FAER+G EKL+
Sbjct: 787 ERRLAGTSTLPDGKGGSAEYPTQAQHELIISGSNLAVFAERVGFSEAGKAARLAEKLAGY 846
Query: 1638 KIKVDEPIVTVESVEIL--GKKLVYDFTVPEHHMYISNGFMSHNCGEEPLYEYESCNLAS 1695
++ + E V I+ G++ VYD TV + H + +NG ++HNCGE PL E C+L +
Sbjct: 847 ARNLNRERFSDEIVSIVPDGEEAVYDVTVEQVHAFDANGVLAHNCGEIPLTVGEPCDLGA 906
Query: 1696 INLAKFVKYDENGKPYFDWDEYAYVIQKVAKYLDNSIDVNKFPLPEIDYNTKLTRRIGVG 1755
INLA +V+ + FD+ + ++ ++LD+ +DVN F L + ++ RR+G+G
Sbjct: 907 INLAAYVRGSD-----FDFAAFRADVRTCVRFLDDVLDVNVFALEDNRVASQDLRRLGLG 961
Query: 1756 MMGLADALFKLGIPYNSEEGFKFMRKVTEYLTFYAYKYSIEAAKKRGTFPLYEKTGYPKG 1815
+MGLADAL K+G+ Y++E G + + + L A S ++RG +P+YE+
Sbjct: 962 VMGLADALIKMGLRYDNESGRQAIYDIMSALREEAVAESERLGQERGFYPVYERNR---- 1017
Query: 1816 ELPVEGFYHPEIWNLPWDKLVEEIKKYGVRNAMVTTCPPTGSVSMIADTSSGIEPIFA-L 1874
E++ RN V T PTG+ SM+ SSGIEP+F+
Sbjct: 1018 ---------------------EQVPHDPRRNVAVLTVAPTGTTSMLMGVSSGIEPVFSPF 1056
Query: 1875 VYKKSVTVGEFY--YVDPVFEAEL----------KRRGLYSEELLKKISDNYGSVQGLEE 1922
+++K +G Y + P+F L K G +++ + +S+N+GSV GL
Sbjct: 1057 IWRK---IGSEYRALLAPLFVELLESYPAPKGMEKDGGWDWDKVTEAVSENHGSVVGLSF 1113
Query: 1923 IPEDMRRVFVTALDIHWLDHLLAQANIQMWLTD-------SASKTINMINEATVEDVKAA 1975
IP+ +++VFV A DI +DH+ Q +Q D S SKTIN+ N A+V+DVK+A
Sbjct: 1114 IPDALQQVFVCAHDISPVDHVRMQGTVQRAFDDGGQLAANSLSKTINLPNSASVDDVKSA 1173
Query: 1976 YLIAHFLGCKGVTVYRDGSLSVQVYSVEGEKKR 2008
Y A+ GCKG+TVYRDGS QV S +K +
Sbjct: 1174 YEEAYRTGCKGITVYRDGSRQFQVLSTSKKKAK 1206
>gi|11499254 ribonucleotide reductase (nrd) [Archaeoglobus fulgidus]
>gi|7483938|pir||G69457 ribonucleoside-diphosphate
reductase (EC 1.17.4.1) large chain nrd - Archaeoglobus
fulgidus >gi|2648891|gb|AAB89584.1| (AE000988)
ribonucleotide reductase (nrd) [Archaeoglobus fulgidus]
Length = 752
Score = 280 bits (708), Expect = 1e-73
Identities = 156/339 (46%), Positives = 219/339 (64%), Gaps = 35/339 (10%)
Query: 1680 CGEEPLYEYESCNLASINLAKFVKYDENGKPYFDWDEYAYVIQKVAKYLDNSIDVNKFPL 1739
CGE+PL YESCNL SINLAKFVK E DWD V+ ++LD+ IDVN +P+
Sbjct: 269 CGEQPLLPYESCNLGSINLAKFVKDGE-----IDWDGLREVVWIAVRFLDDVIDVNSYPI 323
Query: 1740 PEIDYNTKLTRRIGVGMMGLADALFKLGIPYNSEEGFKFMRKVTEYLTFYAYKYSIEAAK 1799
PEI+ TK R+IG+G+MG AD LF L IPY+S+E + KV +++ +++ S + A+
Sbjct: 324 PEIEQMTKANRKIGLGVMGWADMLFLLNIPYDSDEAIQLAEKVMKFIQEESHRASQQLAE 383
Query: 1800 KRGTFPLYEKTGYPKGELPVEGFYHPEIWNLPWDKLVEEIKKYGVRNAMVTTCPPTGSVS 1859
+RG FP + KG + W+K K +RNA TT PTG++S
Sbjct: 384 ERGVFPNW------KGSV--------------WEK-----KGIKMRNATTTTIAPTGTIS 418
Query: 1860 MIADTSSGIEPIFALVYKKSVTVG--EFYYVDPVFEAELKRRGLYSEELLKKISDNYGSV 1917
+IA SSGIEPIFAL YK++ + EF+ ++ +FE L+RRGLY++EL++K+++ GS+
Sbjct: 419 IIAGCSSGIEPIFALAYKRTNILDGEEFFEINEIFEEVLRRRGLYTDELIEKVAEK-GSI 477
Query: 1918 QGLEEIPEDMRRVFVTALDIHWLDHLLAQANIQMWLTDSASKTINMINEATVEDVKAAYL 1977
Q +EEIPED+RRVF ALDI H+ QA Q + ++ SKTINM N AT +DV+ A+L
Sbjct: 478 QEIEEIPEDIRRVFKCALDISPEWHVRMQAAFQKYTDNAVSKTINMPNSATRKDVEKAFL 537
Query: 1978 IAHFLGCKGVTVYRDGSLSVQVYSVE--GEKKRRYKPKP 2014
+A+ LGCKG+TVYRDGS QV ++ E+K+ KP+P
Sbjct: 538 LAYELGCKGITVYRDGSREEQVLRIKKAEEEKKEAKPRP 576
Score = 142 bits (354), Expect = 5e-32
Identities = 78/149 (52%), Positives = 95/149 (63%), Gaps = 7/149 (4%)
Query: 1161 SGPVSFMHLIDAVSDVIKQGGVRRGANMGILEIWHPDIEKFIHAKEKNIGTNVLSNFNIS 1220
SGPVSFM + DA ++ IKQGG RRGANMG+L + HPDIE+FI AK + VL NFNIS
Sbjct: 137 SGPVSFMKIFDAATEQIKQGGRRRGANMGVLNVHHPDIEEFIKAKWEE---GVLRNFNIS 193
Query: 1221 VGIWEDFWEALKEGKKYPLINPRTGEVVKEIDPKTLFEELAYMAWAKADPGVIFFDIINR 1280
V + F EALK+ Y LINPRTGEVV+ + + +F + AW +PG+IF D INR
Sbjct: 194 VAATDAFMEALKKDDDYDLINPRTGEVVRRVPARKIFNLIVEGAWRNGEPGMIFIDTINR 253
Query: 1281 RNVLKEAKGGPIRATNPCVVGETRILTPE 1309
N G I ATNPC GE +L E
Sbjct: 254 FNPTPHV--GQIEATNPC--GEQPLLPYE 278
Score = 78.0 bits (189), Expect = 1e-12
Identities = 34/64 (53%), Positives = 47/64 (73%)
Query: 238 EKEIEEYFKLMTNQVFMPNTPALINSGRPLGMLSACFVVPIEDDMESIMKAAHDVAMIQK 297
E+ E++FKL+ Q FMPN+P L+N+G L LSACFV+P+ED ++ I KA D+A +QK
Sbjct: 51 EEWAEKFFKLLWEQKFMPNSPTLMNAGTELNQLSACFVIPVEDSIDGIFKALWDMAKVQK 110
Query: 298 MGGG 301
GGG
Sbjct: 111 SGGG 114
>gb|AAK41209.1| Ribonucleotide reductase (nrd) [Sulfolobus solfataricus]
Length = 841
Score = 251 bits (634), Expect = 7e-65
Identities = 153/409 (37%), Positives = 231/409 (56%), Gaps = 25/409 (6%)
Query: 1658 LVYDFTVPEHH--MYISNGFMSHNCGEEPLYEYESCNLASINLAKFVKYDENGKPYFDWD 1715
L++ T+ H Y+ ++ CGEEPL +ESCNL SINL KFV + +GK DWD
Sbjct: 429 LLFIDTINRRHPVWYLGKINATNPCGEEPLLPWESCNLGSINLEKFV-IERDGKAAIDWD 487
Query: 1716 EYAYVIQKVAKYLDNSIDVNKFPLPEIDYNTKLTRRIGVGMMGLADALFKLGIPYNSEEG 1775
A +I+ ++LDN ID N++PL +I+ TK TR++G+G+MGLA KLGI Y+S +
Sbjct: 488 GLAEIIRYGVRFLDNVIDANRYPLKQIEDATKRTRKVGLGVMGLARMFIKLGIAYDSVDA 547
Query: 1776 FKFMRKVTEYLTFYAYKYSIEAAKKRGTFPLYEKTGYP---KGELPVEGFYHPE------ 1826
++ +++ ++AYK SIE AK++GTFP Y+ Y + L +
Sbjct: 548 IYLSYQLAKFIFYHAYKASIEIAKEKGTFPTYDARLYRDIWESALDFDSLLQTAEISDKP 607
Query: 1827 ----------IWNLPWDKLVEEIKKYGVRNAMVTTCPPTGSVSMIADTSSGIEPIFALVY 1876
+ L +D L E KYG+RN+ V + PTG++S+IA TSS IEP+FAL +
Sbjct: 608 SDYVKKLTSVVDKLDFDLLKGERLKYGLRNSTVVSIAPTGTISIIAGTSSSIEPLFALAF 667
Query: 1877 KKSVTVGEFYYVDPVFEAELKRRGLYSEELLKKISDNYGSVQGLEEIPEDMRRVFVTALD 1936
++V VG+F +DP+F L++ L E+++KI+++ G + +P +R++F TA +
Sbjct: 668 VRNVAVGKFIEIDPLFLEYLRKYELDDPEVIQKIAES-GIIGDNVFMPRSLRKLFRTAHE 726
Query: 1937 IHWLDHLLAQANIQMWLTDSASKTINMINEATVEDVKAAYLIAHFLGCKGVTVYRDGSLS 1996
+ + H++ QA Q W SKTIN+ +E E V+ YL+A LG KG+TVYRD S
Sbjct: 727 VPPIYHVMHQAAWQQWNDSGTSKTINLRSEEPPETVEKVYLLAWKLGIKGITVYRDKSKQ 786
Query: 1997 VQVYSVEGEKKR-RYKPKPSEYAKKVLLEIVEKEPWIKNFINVDEILNG 2044
QV +K+R Y+ K E KK L + K F+ V E G
Sbjct: 787 QQVIYFGVKKEREEYEKKKEEVEKKTQL-LPSSLRMEKKFVEVSETYAG 834
Score = 103 bits (254), Expect = 2e-20
Identities = 68/187 (36%), Positives = 100/187 (53%), Gaps = 24/187 (12%)
Query: 1161 SGPVSFMHLIDAVSDVIKQGGVRRGANMGILEIWHPDIEKFIHAKEKNIGTNVLSNFNIS 1220
SGPVSFM + DA +DVIKQGG RRGANMG++ WH DIE FI AK + L NFNIS
Sbjct: 259 SGPVSFMKVFDASTDVIKQGGKRRGANMGVMHAWHADIEDFIRAKTGQLKDVQLQNFNIS 318
Query: 1221 VGIWEDFWEALKEGKKYPLINPRTGEVVKEIDPKTLFEELAYMA--WAKADPGVIFFDII 1278
VG ++ F +A+ +G+ PLINPR ++ + + YM+ W + VI ++
Sbjct: 319 VGAYDYFMDAVVKGESVPLINPRKTKIAGRDHEYYITKARGYMSEEWIQE---VILSEL- 374
Query: 1279 NRRNVLKEAKGGPIRATNPCVVGETRILTPEGYI----KAEELFKLAKERGKMEAIAVEG 1334
E KGG + + E++I+T + + K + K + + I V+G
Sbjct: 375 -------EEKGGVVS------LDESKIITVDEALVIASKEGAVVKYVNAKSLFDEI-VKG 420
Query: 1335 IAEGGEP 1341
+ G+P
Sbjct: 421 AWDSGDP 427
>emb|CAC12593.1| (AL445067) ribonucleotide reductase [Thermoplasma acidophilum]
Length = 770
Score = 232 bits (585), Expect = 4e-59
Identities = 142/352 (40%), Positives = 211/352 (59%), Gaps = 39/352 (11%)
Query: 1680 CGEEPLYEYESCNLASINLAKFVKYDENGKPYFDWDEYAYVIQKVAKYLDNSIDVNKFPL 1739
CGE+PL YESCNL SINL+K+V +GK D+D + ++LD+ ID NKFP+
Sbjct: 436 CGEQPLLPYESCNLGSINLSKYVV---DGKK-IDFDRLRETVWTATRFLDDVIDANKFPV 491
Query: 1740 PEIDYNTKLTRRIGVGMMGLADALFKLGIPYNSEEGFKFMRKVTEYLTFYAYKYSIEAAK 1799
+I T++TR+IG+G+MG AD L KL IPYNS E + KV ++ ++K S A+
Sbjct: 492 EQIKKVTRMTRKIGLGVMGFADMLIKLEIPYNSWEALEIGEKVMSFINDESHKASQALAE 551
Query: 1800 KRGTFPLYEKTGYPKGELPVEGFYHPEIWNLPWDKLVEEIKKYGVRNAMVTTCPPTGSVS 1859
+RG FP + + W+K E IK +RN+ TT PTG++S
Sbjct: 552 ERGVFPAW--------------------YGSEWEK--EGIK---MRNSTTTTIAPTGTIS 586
Query: 1860 MIADTSSGIEPIFALVYKKSVTVG-EFYYVDPVFEAELKRRGLYSEELLKKISDNYGSVQ 1918
+IA SS IEPIFAL + + V G E V+P+FE + + G+YSEEL++++++ G+++
Sbjct: 587 IIAGCSSSIEPIFALAFVRHVLNGQELLEVNPLFEEKTRELGIYSEELMRQVAET-GNLE 645
Query: 1919 GLEEIPEDMRRVFVTALDIHWLDHLLAQANIQMWLTDSASKTINMINEATVEDVKAAYLI 1978
+ +I E+++++FVTA +I H+L QA Q + SKTINM ++AT ED+ AY +
Sbjct: 646 NV-KINEEVKKIFVTAHEIDPQWHVLMQATFQRYCDSGVSKTINMRSDATREDIARAYRM 704
Query: 1979 AHFLGCKGVTVYRDGSLSVQVYSVEGEKKRRYKPKPSEYAKKVLLEIVEKEP 2030
A L CKG+TVYRD S +VQV + + + KP E K ++E+V K P
Sbjct: 705 AKDLHCKGITVYRDKSKTVQVLTAGTAETK----KPEE---KEVIELVTKMP 749
Score = 162 bits (406), Expect = 4e-38
Identities = 101/304 (33%), Positives = 175/304 (57%), Gaps = 32/304 (10%)
Query: 3 VEKVMKRDGRIVPFDESRIRWAVQRAMWEVGVRDERKLDEVVKNIVKRINELYDGKIPHI 62
+++V+KRDG +VPF++++I A+ +AM V + +++ +V R+ D + P +
Sbjct: 4 IKEVVKRDGTVVPFEKNKITMAIYKAMLSVKNGTMKDAEQLADKVVARLK---DKERPSV 60
Query: 63 ENIQDIVELELMRAGL-----FEVAKAYILYRKKKAEIREEKKRILNKKELDEIDKRFSI 117
E IQD+VE LM + + +VAK+YILYR+K+ IREEK+ + K +L + ++
Sbjct: 61 EEIQDVVEDVLMTSKIDGKTFTDVAKSYILYREKRRAIREEKELMGVKDDL-----KLTL 115
Query: 118 NALRVLASRYLKRDENGNIIESPRELFERVSILAVIPDLLYDERVFDKDGNYKQDLKRVE 177
NA++VL +RYL +DE+G IIE+PR++F RV+ I + LYD + K G ++ + +
Sbjct: 116 NAVKVLEARYLLKDEDGKIIETPRQMFRRVASHIGIVEALYDYIKYKKTGKVPENAEII- 174
Query: 178 YYLENFEKFDGKYSIGKYKLNKYHFERMVNLYRELAEKGKMKVSIDEFLSMLERGEFDKY 237
GK S + ++ + F M E G ++ + +EF+ ++ +
Sbjct: 175 ----------GKVSPTQEEVLRRAFGYM-------KEDGIIEGTFEEFMDFIQT-KGTSA 216
Query: 238 EKEIEEYFKLMTNQVFMPNTPALINSGRPLGMLSACFVVPIEDDMESIMKAAHDVAMIQK 297
I + ++M++ F+PN+P L+N+G LG LSACFV+P+ D +E I + + A+I K
Sbjct: 217 GHYINRFEEVMSSLDFVPNSPTLMNAGTKLGQLSACFVLPVGDSIEDIFETLKNTALIHK 276
Query: 298 MGGG 301
GGG
Sbjct: 277 SGGG 280
Score = 141 bits (352), Expect = 8e-32
Identities = 75/149 (50%), Positives = 98/149 (65%), Gaps = 6/149 (4%)
Query: 1161 SGPVSFMHLIDAVSDVIKQGGVRRGANMGILEIWHPDIEKFIHAKEKNIGTNVLSNFNIS 1220
SGPVSFM + D +DVIKQGG RRGANMGIL HPDI +FI +K+ VLSNFNIS
Sbjct: 303 SGPVSFMKIFDVTTDVIKQGGKRRGANMGILNYNHPDIMEFILSKDSE--NKVLSNFNIS 360
Query: 1221 VGIWEDFWEALKEGKKYPLINPRTGEVVKEIDPKTLFEELAYMAWAKADPGVIFFDIINR 1280
VG+ +DF++ L L+NPRT +++K I + +++ + AW ADPG+IF D INR
Sbjct: 361 VGVTDDFFDKLDNDDYVDLVNPRTKKIMKRIKAREIWDAIIDQAWKTADPGLIFLDEINR 420
Query: 1281 RNVLKEAKGGPIRATNPCVVGETRILTPE 1309
+N +K G I +TNPC GE +L E
Sbjct: 421 KNPVKNV--GDIESTNPC--GEQPLLPYE 445
>pir||T37459 ribonucleotide reductase (EC 1.17.4.-), B12-dependent - Thermoplasma
acidophilum >gi|1657993|gb|AAB18239.1| (U73619)
ribonucleotide reductase [Thermoplasma acidophilum]
Length = 857
Score = 229 bits (579), Expect = 2e-58
Identities = 141/352 (40%), Positives = 210/352 (59%), Gaps = 39/352 (11%)
Query: 1680 CGEEPLYEYESCNLASINLAKFVKYDENGKPYFDWDEYAYVIQKVAKYLDNSIDVNKFPL 1739
CGE+PL YESCNL SINL+K+V +GK D+D + ++LD+ ID NKFP+
Sbjct: 434 CGEQPLLPYESCNLGSINLSKYVV---DGKK-IDFDRLRETVWTATRFLDDVIDANKFPV 489
Query: 1740 PEIDYNTKLTRRIGVGMMGLADALFKLGIPYNSEEGFKFMRKVTEYLTFYAYKYSIEAAK 1799
+I T++TR+IG+G+MG AD L KL IPYNS E + KV ++ ++K S A+
Sbjct: 490 EQIKKVTRMTRKIGLGVMGFADMLIKLEIPYNSWEALEIGEKVMSFINDESHKASQALAE 549
Query: 1800 KRGTFPLYEKTGYPKGELPVEGFYHPEIWNLPWDKLVEEIKKYGVRNAMVTTCPPTGSVS 1859
+R FP + + W+K E IK +RN+ TT PTG++S
Sbjct: 550 ERAVFPAW--------------------YGSEWEK--EGIK---MRNSTTTTIAPTGTIS 584
Query: 1860 MIADTSSGIEPIFALVYKKSVTVG-EFYYVDPVFEAELKRRGLYSEELLKKISDNYGSVQ 1918
+IA SS IEPIFAL + + V G E V+P+FE + + G+YSEEL++++++ G+++
Sbjct: 585 IIAGCSSSIEPIFALAFVRHVLNGQELLEVNPLFEEKTRELGIYSEELMRQVAET-GNLE 643
Query: 1919 GLEEIPEDMRRVFVTALDIHWLDHLLAQANIQMWLTDSASKTINMINEATVEDVKAAYLI 1978
+ +I E+++++FVTA +I H+L QA Q + SKTINM ++AT ED+ AY +
Sbjct: 644 NV-KINEEVKKIFVTAHEIDPQWHVLMQATFQRYCDSGVSKTINMRSDATREDIARAYRM 702
Query: 1979 AHFLGCKGVTVYRDGSLSVQVYSVEGEKKRRYKPKPSEYAKKVLLEIVEKEP 2030
A L CKG+TVYRD S +VQV + + + KP E K ++E+V K P
Sbjct: 703 AKDLHCKGITVYRDKSKTVQVLTAGTAETK----KPEE---KEVIELVTKMP 747
Score = 162 bits (406), Expect = 4e-38
Identities = 101/304 (33%), Positives = 175/304 (57%), Gaps = 32/304 (10%)
Query: 3 VEKVMKRDGRIVPFDESRIRWAVQRAMWEVGVRDERKLDEVVKNIVKRINELYDGKIPHI 62
+++V+KRDG +VPF++++I A+ +AM V + +++ +V R+ D + P +
Sbjct: 2 IKEVVKRDGTVVPFEKNKITMAIYKAMLSVKNGTMKDAEQLADKVVARLK---DKERPSV 58
Query: 63 ENIQDIVELELMRAGL-----FEVAKAYILYRKKKAEIREEKKRILNKKELDEIDKRFSI 117
E IQD+VE LM + + +VAK+YILYR+K+ IREEK+ + K +L + ++
Sbjct: 59 EEIQDVVEDVLMTSKIDGKTFTDVAKSYILYREKRRAIREEKELMGVKDDL-----KLTL 113
Query: 118 NALRVLASRYLKRDENGNIIESPRELFERVSILAVIPDLLYDERVFDKDGNYKQDLKRVE 177
NA++VL +RYL +DE+G IIE+PR++F RV+ I + LYD + K G ++ + +
Sbjct: 114 NAVKVLEARYLLKDEDGKIIETPRQMFRRVASHIGIVEALYDYIKYKKTGKVPENAEII- 172
Query: 178 YYLENFEKFDGKYSIGKYKLNKYHFERMVNLYRELAEKGKMKVSIDEFLSMLERGEFDKY 237
GK S + ++ + F M E G ++ + +EF+ ++ +
Sbjct: 173 ----------GKVSPTQEEVLRRAFGYM-------KEDGIIEGTFEEFMDFIQT-KGTSA 214
Query: 238 EKEIEEYFKLMTNQVFMPNTPALINSGRPLGMLSACFVVPIEDDMESIMKAAHDVAMIQK 297
I + ++M++ F+PN+P L+N+G LG LSACFV+P+ D +E I + + A+I K
Sbjct: 215 GHYINRFEEVMSSLDFVPNSPTLMNAGTKLGQLSACFVLPVGDSIEDIFETLKNTALIHK 274
Query: 298 MGGG 301
GGG
Sbjct: 275 SGGG 278
Score = 141 bits (352), Expect = 8e-32
Identities = 75/149 (50%), Positives = 98/149 (65%), Gaps = 6/149 (4%)
Query: 1161 SGPVSFMHLIDAVSDVIKQGGVRRGANMGILEIWHPDIEKFIHAKEKNIGTNVLSNFNIS 1220
SGPVSFM + D +DVIKQGG RRGANMGIL HPDI +FI +K+ VLSNFNIS
Sbjct: 301 SGPVSFMKIFDVTTDVIKQGGKRRGANMGILNYNHPDIMEFILSKDSE--NKVLSNFNIS 358
Query: 1221 VGIWEDFWEALKEGKKYPLINPRTGEVVKEIDPKTLFEELAYMAWAKADPGVIFFDIINR 1280
VG+ +DF++ L L+NPRT +++K I + +++ + AW ADPG+IF D INR
Sbjct: 359 VGVTDDFFDKLDNDDYVDLVNPRTKKIMKRIKAREIWDAIIDQAWKTADPGLIFLDEINR 418
Query: 1281 RNVLKEAKGGPIRATNPCVVGETRILTPE 1309
+N +K G I +TNPC GE +L E
Sbjct: 419 KNPVKNV--GDIESTNPC--GEQPLLPYE 443
>pir||G69186 ribonucleoside-diphosphate reductase (EC 1.17.4.1) large chain,
intein containing precursor - Methanobacterium
thermoautotrophicum (strain Delta H)
>gi|2621734|gb|AAB85157.1| (AE000845) ribonucleotide
reductase, large subunit [Methanobacterium
thermoautotrophicum]
Length = 703
Score = 229 bits (578), Expect = 2e-58
Identities = 132/350 (37%), Positives = 204/350 (57%), Gaps = 33/350 (9%)
Query: 1645 IVTVESVEILGKKLVYDFTVPEHHMYISNGFMSHNCGEEPLYEYESCNLASINLAKFVKY 1704
+ T + G++ VYD TV + +NGF+ HNCGE+PL +ESCNL S+NL+ V
Sbjct: 365 LATFRGLRGAGRQDVYDATVYGASAFTANGFIVHNCGEQPLLTHESCNLGSVNLSLMV-- 422
Query: 1705 DENGKPYFDWDEYAYVIQKVAKYLDNSIDVNKFPLPEIDYNTKLTRRIGVGMMGLADALF 1764
G +W++ I +LDN IDVN +PL ++ T TR+IG+G+MG AD L
Sbjct: 423 ---GPSGINWEKLRRTIHVAVHFLDNVIDVNSYPLRPVEEMTLRTRKIGLGVMGFADMLI 479
Query: 1765 KLGIPYNSEEGFKFMRKVTEYLTFYAYKYSIEAAKKRGTFPLYEKTGYPKGELPVEGFYH 1824
KLGIPYNS + +V +++ A + S+E A++RG+FP + KG
Sbjct: 480 KLGIPYNSVAALEVAGRVMSFISSEARRASMELARERGSFPEF------KG--------- 524
Query: 1825 PEIWNLPWDKLVEEIKKYGVRNAMVTTCPPTGSVSMIADTSSGIEPIFALVYKKSVTVGE 1884
IW++ + +RNA +TT PTGS+S+IA TSSGIEP+FA+ + +++
Sbjct: 525 -SIWDIQGFEC--------MRNATLTTIAPTGSLSIIAGTSSGIEPLFAVSFTRNILGRS 575
Query: 1885 FYYVDPVFEAELKRRGLYSEELLKKISDNYGSVQGLEEIPEDMRRVFVTALDIHWLDHLL 1944
F+ + P+F+ R S E + ++ GS++G+ +P +RR+FVTA +I + H+
Sbjct: 576 FHELHPLFKTMAGRLDKRSLEAI----ESRGSLRGVPGVPARIRRLFVTAHEIDPVFHVK 631
Query: 1945 AQANIQMWLTDSASKTINMINEATVEDVKAAYLIAHFLGCKGVTVYRDGS 1994
QA Q ++ ++ SKT+N+ +++ DV+ + AH LGCKGVTVYR GS
Sbjct: 632 MQAAFQRYVDNAVSKTVNLPADSSPADVERVFRAAHELGCKGVTVYRYGS 681
Score = 143 bits (356), Expect = 3e-32
Identities = 91/268 (33%), Positives = 134/268 (49%), Gaps = 53/268 (19%)
Query: 1161 SGPVSFMHLIDAVSDVIKQGGVRRGANMGILEIWHPDIEKFIHAKEKNIGTNVLSNFNIS 1220
SGPVSFM + D DVIKQGG RRGANMG+L + HPDI FI AK + L NFN+S
Sbjct: 138 SGPVSFMRIFDVAVDVIKQGGRRRGANMGVLHVSHPDIFSFIDAKSRE---GPLRNFNLS 194
Query: 1221 VGIWEDFWEALKEGKKYPLINPRTGEVVKEIDPKTLFEELAYMAWAKADPGVIFFDIINR 1280
V + ++F + + LINPR GEVV ++ + + + + AW DPG++F D INR
Sbjct: 195 VAVPDEF----MDDRPVDLINPRNGEVVDSVESRVILKRIVEAAWRSGDPGILFEDRINR 250
Query: 1281 RNVLKEAKGGPIRATNPCVVGETRILTPEGYIKAEELFKLAKERGKMEAIAVEGIAEGGE 1340
N + G I ATNPCV G+T ++T G EL GK + G G
Sbjct: 251 YNPTPQL--GRIEATNPCVSGDTIVMTSGGPRTVAEL------EGKPFTALIRG---SGY 299
Query: 1341 PYAYSLEILLPGDKQVKYETVHGNAVEVADPVSVPAYVWKVGMKEVARVRTKEGYEITAT 1400
P P+ ++ ++V +RT+EG+ + T
Sbjct: 300 P--------------------------------CPSGFFRTCERDVYDLRTREGHCLRLT 327
Query: 1401 LDHKLMTPEG---WKEIKDLKPGDKILL 1425
DH+++ +G W+ +L+ GD++++
Sbjct: 328 HDHRVLVMDGGLEWRAAGELERGDRLVM 355
Score = 71.8 bits (173), Expect = 8e-11
Identities = 29/60 (48%), Positives = 44/60 (73%)
Query: 242 EEYFKLMTNQVFMPNTPALINSGRPLGMLSACFVVPIEDDMESIMKAAHDVAMIQKMGGG 301
E ++ +M N F+PN+P L+N+G P+ LSACFV+P+ED ++SI + D+A+I K GGG
Sbjct: 56 EAFYSVMGNLEFLPNSPTLMNAGTPINQLSACFVLPVEDSIDSIFSSLRDMAIIHKSGGG 115
>pir||F72414 ribonucleotide reductase, B12-dependent - Thermotoga maritima (strain
MSB8) >gi|2440216|emb|CAA73377.1| (Y12877) ribonucleotide
reductase [Thermotoga maritima]
>gi|4980610|gb|AAD35212.1|AE001698_1 (AE001698)
ribonucleotide reductase, B12-dependent [Thermotoga
maritima]
Length = 827
Score = 218 bits (549), Expect = 6e-55
Identities = 133/327 (40%), Positives = 190/327 (57%), Gaps = 18/327 (5%)
Query: 1680 CGEEPLYEYESCNLASINLAKFVKYDENGKPYFDWDEYAYVIQKVAKYLDNSIDVNKFPL 1739
CGE L +YE+CNL SI++AKF NG + D + ++Q ++LDN IDVN FP+
Sbjct: 322 CGEIGLSDYEACNLGSIDVAKFYN---NG--FVDLEALQELVQIAVRFLDNVIDVNVFPI 376
Query: 1740 PEIDYNTKLTRRIGVGMMGLADALFKLGIPYNSEEGFKFMRKVTEYLTFYAYKYSIEAAK 1799
+I K +RR+G+G+MG AD L+KL IPYNS+E F + ++ +A++ S E K
Sbjct: 377 DKITKAVKESRRLGLGIMGFADLLYKLEIPYNSQEARDFAANLMAFIALHAHRTSYELGK 436
Query: 1800 KRGTFPLYEKTGYPKGELPVEGFYHPEIWNLP-WDKLVEEIKKYGV---RNAMVTTCPPT 1855
++G FPL E + Y E + P + +D + E+ K RN + T PT
Sbjct: 437 EKGNFPLLEISRY-----RTEDNFVPFAMGMSNYDDEIREVMKMTKEFRRNVALLTIAPT 491
Query: 1856 GSVSMIADTSSGIEPIFALVYKKSVTVGEFYYVDPVFEAELKRRGLYSEELLKKISDNY- 1914
GS+S IADTSSG+EP F L Y + VT E +P+ R + E+LK+I
Sbjct: 492 GSISNIADTSSGLEPNFLLAYTRFVT-KEDGTKEPLLYVNQVLREKLNPEILKRIEKELI 550
Query: 1915 --GSVQGLEEIPEDMRRVFVTALDIHWLDHLLAQANIQMWLTDSASKTINMINEATVEDV 1972
GS++ + ++PE +++VFV ALDI +DHLL Q Q ++ ++ SKTINM ATV+DV
Sbjct: 551 EKGSLKDIPDVPEKIKKVFVVALDIDPMDHLLMQDAFQRYVDNNISKTINMPQSATVDDV 610
Query: 1973 KAAYLIAHFLGCKGVTVYRDGSLSVQV 1999
YL A +G+TVYRDGSL QV
Sbjct: 611 LNVYLEALRTNVRGITVYRDGSLQTQV 637
Score = 108 bits (267), Expect = 7e-22
Identities = 65/147 (44%), Positives = 89/147 (60%), Gaps = 6/147 (4%)
Query: 1155 GIYTSNSGPVSFMHLIDAVSDVIKQGGVRRGANMGILEIWHPDIEKFIHAKEKNIGTNVL 1214
G + SGPVSFMH+ ++ V+KQG RRGA MGIL I HPDIE+FI AK++N G VL
Sbjct: 179 GTHGKASGPVSFMHVFNSAISVVKQGYRRRGALMGILNINHPDIEEFIDAKKENTGEAVL 238
Query: 1215 SNFNISVGIWEDFWEALK---EGKKYPLINPRTGEVVKEIDPKTLFEELAYMAWAKADPG 1271
+ FN+SVG D E LK E + L +PR+ + K++ + LF ++A AW DPG
Sbjct: 239 NFFNLSVGFPMDKKEILKLYEEDGELELSHPRS-TIRKKVKIRELFRKIATNAWKSGDPG 297
Query: 1272 VIFFDIINRRNVLKEAKGGPIRATNPC 1298
+ F +N+ L + I +TNPC
Sbjct: 298 LAFLGEMNKYYPLYPHR--KINSTNPC 322
>gi|9630286 ribunucleotide reductase large subunit [Bacteriophage SPBc2]
>gi|7475802|pir||T12925 ribunucleotide reductase large
chain - Bacillus subtilis phage SPBc2
>gi|3025639|gb|AAC13134.1| (AF020713) ribunucleotide
reductase large subunit [Bacteriophage SPBc2]
Length = 1084
Score = 205 bits (517), Expect = 4e-51
Identities = 208/841 (24%), Positives = 356/841 (41%), Gaps = 151/841 (17%)
Query: 1156 IYTSNSGPVSFMHLIDAVSDVIKQGGVRRGANMGILEIWHPDIEKFIHAKEKNIGTNV-L 1214
+ + G V M L+D Q G R+G+ L ++HPDI F+ K+ + +V +
Sbjct: 215 VENATKGVVGVMKLLDNAFRYADQMGQRQGSGAVYLSVFHPDITDFLDTKKISADEDVRV 274
Query: 1215 SNFNISVGIWEDFWEALKEGKKYPLINPRT-----GEVVKEID----------------- 1252
+I V + + F E +E K Y + P + G+ + E+D
Sbjct: 275 KTLSIGVVVPDKFIELAREDKDYYMFYPHSVYKEYGQYLDELDINEMYDELVENPRVRKA 334
Query: 1253 ---PKTLFEELAYMAWAKADPGVIFFDIINRRNVLKEAKGGPIRATNPCVVGETRILTPE 1309
+ L E+LA + P ++F D +N+ V ++ +N CV GET +LT
Sbjct: 335 KGNARKLLEQLAILRSESGYPYIMFADNVNK--VHPNEHISKVKFSNLCVTGETLLLTEN 392
Query: 1310 GYIKAEELFKLAKERGKMEAIAVEGIAEGGEPYAYSLEILLPGDKQVKYETVHGNAVEVA 1369
GY KA +L+K + L++++ D + K V +
Sbjct: 393 GYEKAADLYKKQND----------------------LKVVI--DNRTKDFAVGSKGTTIV 428
Query: 1370 DPVSVPAYVWKVGMKEVARVRTKEGYEITATLDHKLMTPEGWK----EIKDLKPGDKILL 1425
D ++P + K E+ +V+TK+GYEI AT HK + ++ LK GDK+L+
Sbjct: 429 D--AIPMQLTKKDA-EIFKVKTKQGYEIRATEWHKFYVKRDGEIQKLQLNQLKTGDKLLV 485
Query: 1426 PRFEVEEDFGSESIGE-DLAFVLGWFIGDGYLNVKDKRAWFYFNAEK-EEEIAWKIREIL 1483
E +G I E DLA+++G GDG + K + + Y N + E+++ + I+
Sbjct: 486 Q--SAEGAYGK--IHEPDLAYIMGIIAGDGTITEKTAKIYLYDNKKVLEQKVTDAVHRII 541
Query: 1484 AKRFEIKAEPHRYGNQIKLGVRGKAYE---WLESIV-----------KTNEKRIPEIVYR 1529
K +A H + + ++ S V K + R+PE +++
Sbjct: 542 QKHKVDRAYKHNTSLLPTFNMANPEKQDLLYMNSTVLFDILKKFGMNKETKTRVPEFIFQ 601
Query: 1530 LKPNEIASFLRGLFSADGYVDND-----MAIRLTSKSRELLREVQDLLLLFGILSKIYER 1584
A++L GLF DG V+ + + I LTS E L++VQ LLL G+ + IY
Sbjct: 602 ANKETQAAYLSGLFQTDGCVNANHKAKALTIELTSIHYESLQDVQKLLLNMGVYTTIYSN 661
Query: 1585 PYKREFKYTTKDGEERTYTTEGYYELVIANY-SRKIFAERIGLEGYKMEKLSL------E 1637
+ + G + Y + +++ I + SR++F + ++ Y + K +L
Sbjct: 662 NKRSQELLPDGKGGSKLYNVKPTHKISIQDRNSRELFMSIVEMKEYDVYKFNLLTETLQP 721
Query: 1638 KIKVDEPIVTVE--SVEILGKKLVYDFTVPEHHMYISNGFMSHNCGE-------EPLYEY 1688
K + + T E S+E G + VYD T ++H I NG ++ NC E +Y
Sbjct: 722 KSRKPKHDFTAEIISIEEDGVEDVYDTTQEDYHSLIFNGIVTGNCSEVLQSSQVSVYTDY 781
Query: 1689 E---------SCNLASINLAKFVKYDENGKPYFDWDEYAYVIQKVAKYLDNSID------ 1733
+ SCNL S+N+ + Q +A + +ID
Sbjct: 782 DKEDEIGLDISCNLGSMNIVNVMSN-----------------QSIASTVRIAIDSLTTVT 824
Query: 1734 --VNKFPLPEIDYNTKLTRRIGVGMMGLADALFKLGIPYNSEEGFKFMRKVTEYLTFYAY 1791
N P + L R IG+G M L L + I Y SEE F + FY+
Sbjct: 825 RKTNIVNAPAVARANTLMRSIGLGQMNLHGFLAQNNIAYESEEAKDFANTYFMMVNFYSL 884
Query: 1792 KYSIEAAKKRG-TFPLYEKTGYPKGEL---PVEGFYHPEIWNLP-------------WDK 1834
+ S+E A++ G T+ ++ + Y GE V Y P+ + W K
Sbjct: 885 QRSMEIARETGETYYKFDGSTYKSGEYFEKYVTNDYSPQYEKVKKLFGDQHIPNIQDWMK 944
Query: 1835 LVEEIKKYGVRNAMVTTCPPTGSVSMIADTSSGIEPIFALVYKKSVTVGEFYYVDPVFEA 1894
L E++ KYG+ ++ PTGS+S + +++G+ PI + +++ + YY P A
Sbjct: 945 LKEDVMKYGLYHSYRQAIAPTGSISYVQSSTAGVMPIMERIEERTYGNSKTYYPMPGLSA 1004
Query: 1895 E 1895
+
Sbjct: 1005 Q 1005
Score = 107 bits (265), Expect = 1e-21
Identities = 130/516 (25%), Positives = 206/516 (39%), Gaps = 103/516 (19%)
Query: 704 NFSKLRPEGDIVGTTTGAACFTGDTRILTEKGLIPIEEIVHETGKKPKVVTHAGLKD--- 760
N +K+ P I C TG+T +LTE G ++ ++ KVV KD
Sbjct: 362 NVNKVHPNEHISKVKFSNLCVTGETLLLTENGYEKAADL-YKKQNDLKVVIDNRTKDFAV 420
Query: 761 ----------IIETYDNGEMEVFRVTTEDGYELKVTGDHKFLVFDENGNPTLKPLKELKV 810
I + E+F+V T+ GYE++ T HKF V +G L +LK
Sbjct: 421 GSKGTTIVDAIPMQLTKKDAEIFKVKTKQGYEIRATEWHKFYV-KRDGEIQKLQLNQLKT 479
Query: 811 GDYVYILAPEWKGGEYVELDTNIELKGKGYNVNLPSKLDEKLAYLLGIIYADGHIR---- 866
GD + + + E G+ E D LAY++GII DG I
Sbjct: 480 GDKLLVQSAEGAYGKIHEPD---------------------LAYIMGIIAGDGTITEKTA 518
Query: 867 --HYFENGKRKNSKIEIYLHQDETEIKEKVKRYFKEIFGIEPKEFLKEEQHKVILVIPST 924
+ ++N K K+ +H+ K KV R +K + P + + + +L + ST
Sbjct: 519 KIYLYDNKKVLEQKVTDAVHRIIQ--KHKVDRAYKHNTSLLPTFNMANPEKQDLLYMNST 576
Query: 925 KIVKFLEINGLLKDKSENIRVPEAIFRSRPSVIAAFLAGFFDGDGSIDQNYR-----IAF 979
+ L+ G+ +K RVPE IF++ AA+L+G F DG ++ N++ I
Sbjct: 577 VLFDILKKFGM--NKETKTRVPEFIFQANKETQAAYLSGLFQTDGCVNANHKAKALTIEL 634
Query: 980 KSISREFIKEAQLLFLALGIVTSIQEYNPPNPNNKTVYTLRVQTRDMKIKAFNVLKESVK 1039
SI E +++ Q L L +G+ T+I NNK L + K +NV K + K
Sbjct: 635 TSIHYESLQDVQKLLLNMGVYTTIYS------NNKRSQELLPDGKGGS-KLYNV-KPTHK 686
Query: 1040 LSKIMKEAISKLEENGKNKKFSFPFNAIYHIKDPKIRAKIQRDYKILSYNSKVTHRAFIN 1099
+S +++ + F +I +K +Y + +N +
Sbjct: 687 IS---------IQDRNSRELFM----SIVEMK----------EYDVYKFN-------LLT 716
Query: 1100 NILKLKEELGLDDEEVKYFEMLSKLYPTKITKIEPLGKAHVYDLQVEDVHLLTGNGIYTS 1159
L+ K D + +I IE G VYD ED H L NGI T
Sbjct: 717 ETLQPKSRKPKHD------------FTAEIISIEEDGVEDVYDTTQEDYHSLIFNGIVTG 764
Query: 1160 NSGPVSFMHLIDAVSDVIKQG--GVRRGANMGILEI 1193
N V + +D K+ G+ N+G + I
Sbjct: 765 NCSEVLQSSQVSVYTDYDKEDEIGLDISCNLGSMNI 800
>pir||A70933 probable nrdZ protein - Mycobacterium tuberculosis (strain H37RV)
>gi|2909629|emb|CAA17441.1| (AL021942) nrdZ
[Mycobacterium tuberculosis]
Length = 692
Score = 204 bits (513), Expect = 1e-50
Identities = 120/327 (36%), Positives = 181/327 (54%), Gaps = 32/327 (9%)
Query: 1680 CGEEPLYEYESCNLASINLAKFVKYDENGKPYFDWDEYAYVIQKVAKYLDNSIDVNKFPL 1739
CGE PL YESCNL SINLA+ + +G+ DWD V ++LD+ IDV+++P
Sbjct: 377 CGEVPLLPYESCNLGSINLARMLA---DGR--VDWDRLEEVAGVAVRFLDDVIDVSRYPF 431
Query: 1740 PEIDYNTKLTRRIGVGMMGLADALFKLGIPYNSEEGFKFMRKVTEYLTFYAYKYSIEAAK 1799
PE+ + TR+IG+G+MGLA+ L LGIPY+SEE + ++ + A+ S A+
Sbjct: 432 PELGEAARATRKIGLGVMGLAELLAALGIPYDSEEAVRLATRLMRRIQQAAHTASRRLAE 491
Query: 1800 KRGTFPLYEKTGYPKGELPVEGFYHPEIWNLPWDKLVEEIKKYGVRNAMVTTCPPTGSVS 1859
+RG FP + + + + P RNA VT+ PTG++S
Sbjct: 492 ERGAFPAFTDSRFARSG--------PR------------------RNAQVTSVAPTGTIS 525
Query: 1860 MIADTSSGIEPIFALVYKKSVTVGEFYYVDPVFEAELKRRGLYSEELLKKISDNYGSVQG 1919
+IA T++GIEP+FA+ + +++ V+P F+ + RG Y +EL+ +I+ G V+G
Sbjct: 526 LIAGTTAGIEPMFAIAFTRAIVGRHLLEVNPCFDRLARDRGFYRDELIAEIAQR-GGVRG 584
Query: 1920 LEEIPEDMRRVFVTALDIHWLDHLLAQANIQMWLTDSASKTINMINEATVEDVKAAYLIA 1979
+P ++R F TA +I HL QA +Q + + SKT+N+ ATV+DV+A Y+ A
Sbjct: 585 YPRLPAEVRAAFPTAAEIAPQWHLRMQAAVQRHVEAAVSKTVNLPATATVDDVRAIYVAA 644
Query: 1980 HFLGCKGVTVYRDGSLSVQVYSVEGEK 2006
KG+TVYR GS QV S K
Sbjct: 645 WKAKVKGITVYRYGSREGQVLSYAAPK 671
Score = 114 bits (283), Expect = 1e-23
Identities = 63/149 (42%), Positives = 91/149 (60%), Gaps = 6/149 (4%)
Query: 1161 SGPVSFMHLIDAVSDVIKQGGVRRGANMGILEIWHPDIEKFIHAKEKNIGTNVLSNFNIS 1220
SGPVSF+ L D+ + V+ GG RRGA M +L++ HPDI F+ AK ++ + L +FN+S
Sbjct: 244 SGPVSFLRLYDSAAGVVSMGGRRRGACMAVLDVSHPDICDFVTAKAES--PSELPHFNLS 301
Query: 1221 VGIWEDFWEALKEGKKYPLINPRTGEVVKEIDPKTLFEELAYMAWAKADPGVIFFDIINR 1280
VG+ + F A++ + L+NPRTG++V + LF+ + A A DPG++F D INR
Sbjct: 302 VGVTDAFLRAVERNGLHRLVNPRTGKIVARMPAAELFDAICKAAHAGGDPGLVFLDTINR 361
Query: 1281 RNVLKEAKGGPIRATNPCVVGETRILTPE 1309
N + G I ATNPC GE +L E
Sbjct: 362 ANPVPGR--GRIEATNPC--GEVPLLPYE 386
Score = 90.9 bits (222), Expect = 1e-16
Identities = 57/142 (40%), Positives = 80/142 (56%), Gaps = 9/142 (6%)
Query: 5 KVMKRDGRIVPFDESRIRWAVQRAMWEVGVRDERKLDEVVKNIVKRINELYDGKIPHIEN 64
KV +RDG +VPFD +RI AV RA EV D ++ + K + + I +E+
Sbjct: 8 KVRRRDGTLVPFDIARIEAAVTRAAREVACDDP----DMPGTVAKAVADALGRGIAPVED 63
Query: 65 IQDIVELELMRAGLFEVAKAYILYRKKKAEIREEKKRILNKKELDEIDKRFSINALRVLA 124
IQD VE L AGL +VA+ YI+YR+++AE+R K + + EL + S+ A+ VL
Sbjct: 64 IQDCVEARLGEAGLDDVARVYIIYRQRRAELRTAKALLGVRDEL-----KLSLAAVTVLR 118
Query: 125 SRYLKRDENGNIIESPRELFER 146
RYL DE G ES EL +R
Sbjct: 119 ERYLLHDEQGRPAESTGELMDR 140
>gb|AAG19899.1| (AE005073) ribonucleoside reductase large chain; NrdB2 [Halobacterium
sp. NRC-1]
Length = 1051
Score = 180 bits (451), Expect = 2e-43
Identities = 140/492 (28%), Positives = 226/492 (45%), Gaps = 47/492 (9%)
Query: 1590 FKYTTKDGEERTYTTEGYYELVIANYSRKIFAERIGLEGYKM--EKLSLEKIKVDEPIVT 1647
F + GEE T+T E IA K R GL Y E+L+L ++ IV
Sbjct: 336 FMEALEAGEEYTFTNPRTGEAHIATEETKEMYSRYGLGHYVTPGEELTLPAEELWSRIV- 394
Query: 1648 VESVEILGKK-LVYDFTVPEHHMYISNGFMSHN------CGEEPLYEYESCNLASINLAK 1700
E G+ ++Y V + H + H CGE+PL EYE+CNL INL+
Sbjct: 395 -EGAHENGEPGVIYLERVNDEHSFDVEEHPDHRILATNPCGEQPLEEYEACNLGHINLST 453
Query: 1701 FVKYD----------------ENGKPYF-----DWDEYAYVIQKVAKYLDNSIDVNKFPL 1739
D E G F D D + I+ ++L+N + ++ FP+
Sbjct: 454 LAAQDAPDWRVWSQTHDFDTLEAGVSRFLDEAMDTDAFQRRIEMGTRFLENVVTMSDFPV 513
Query: 1740 PEIDYNTKLTRRIGVGMMGLADALFKLGIPYNSEEGFKFMRKVTEYLTFYAYKYSIEAAK 1799
PEI+ R+IG+G+MGLA +LG+ Y SEEG + ++ + + + S E A
Sbjct: 514 PEIEQKVSEMRKIGLGVMGLAQLYIQLGVKYGSEEGNEIASQLMQTINHDSKTASHELAL 573
Query: 1800 KRGTFPLYEKTGYPKGELPVEGFYHPEIWNLPWDKLVEEIKKYGVRNAMVTTCPPTGSVS 1859
+RG+F ++ + + + F H + + Y +RN TT PTG+ S
Sbjct: 574 ERGSFDEWDNSKFAAPTEYADWFEHHT-----GEDAADWADGYPIRNHNTTTIAPTGTTS 628
Query: 1860 MIADTSSGIEPIFALVYKKSVT--------VGEF--YYVDPVFEAELKRRGLYSEELLKK 1909
M+ +T+ G EPI+ + Y K+V+ + EF Y++ + + ++ + + E +
Sbjct: 629 MVGNTTGGCEPIYNVAYYKNVSDDVQGDEMLVEFDDYFLRTLEDNDIDVQAVKEEAQTQM 688
Query: 1910 ISDNYGSVQGLEEIPEDMRRVFVTALDIHWLDHLLAQANIQMWLTDSASKTINMINEATV 1969
++++ V GL +P+ + +FV D+ DH Q Q + + SKT N N+A+V
Sbjct: 689 ANNDFDGVDGLTTVPDAIGELFVVTSDLSGKDHAAVQTACQNGVDSAISKTCNFPNDASV 748
Query: 1970 EDVKAAYLIAHFLGCKGVTVYRDGSLSVQVYSVEGEKKRRYKPKPSEYAKKVLLEIVEKE 2029
ED+ Y + G KGVTVYRDG+ S QV + + E A ++ I E
Sbjct: 749 EDMDEVYRYIYDNGGKGVTVYRDGTRSKQVLTTRADNTEFSGLDEEEAAAAMVDTIQETF 808
Query: 2030 PWIKNFINVDEI 2041
I+ F+ D+I
Sbjct: 809 GGIEGFLENDDI 820
>pir||A69927 ribonucleoside-diphosphate reductase (alph) homolog yosO - Bacillus
subtilis >gi|2634398|emb|CAB13897.1| (Z99114) similar to
ribonucleoside-diphosphate reductase (alpha subunit)
[Bacillus subtilis]
Length = 786
Score = 179 bits (449), Expect = 3e-43
Identities = 183/730 (25%), Positives = 313/730 (42%), Gaps = 127/730 (17%)
Query: 1241 NPRTGEVVKEIDPKTLFEELAYMAWAKADPGVIFFDIINRRNVLKEAKGGPIRATNPCVV 1300
NPR + + + + L E+LA + P ++F D +N+ V ++ +N CV
Sbjct: 30 NPRVRKA--KGNARKLLEQLAILRSESGYPYIMFADNVNK--VHPNEHISKVKFSNLCVT 85
Query: 1301 GETRILTPEGYIKAEELFKLAKERGKMEAIAVEGIAEGGEPYAYSLEILLPGDKQVKYET 1360
GET +LT GY KA +L+K + L++++ D + K
Sbjct: 86 GETLLLTENGYEKAADLYKKQND----------------------LKVVI--DNRTKDFA 121
Query: 1361 VHGNAVEVADPVSVPAYVWKVGMKEVARVRTKEGYEITATLDHKLMTPEGWK----EIKD 1416
V + D ++P + K E+ +V+TK+GYEI AT HK + ++
Sbjct: 122 VGSKGTTIVD--AIPMQLTKKDA-EIFKVKTKQGYEIRATEWHKFYVKRDGEIQKLQLNQ 178
Query: 1417 LKPGDKILLPRFEVEEDFGSESIGE-DLAFVLGWFIGDGYLNVKDKRAWFYFNAEK-EEE 1474
LK GDK+L+ E +G I E DLA+++G GDG + K + + Y N + E++
Sbjct: 179 LKTGDKLLVQ--SAEGAYGK--IHEPDLAYIMGIIAGDGTITEKTAKIYLYDNKKVLEQK 234
Query: 1475 IAWKIREILAKRFEIKAEPHRYGNQIKLGVRGKAYE---WLESIV-----------KTNE 1520
+ + I+ K +A H + + ++ S V K +
Sbjct: 235 VTDAVHRIIQKHKVDRAYKHNTSLLPTFNMANPEKQDLLYMNSTVLFDILKKFGMNKETK 294
Query: 1521 KRIPEIVYRLKPNEIASFLRGLFSADGYVDND-----MAIRLTSKSRELLREVQDLLLLF 1575
R+PE +++ A++L GLF DG V+ + + I LTS E L++VQ LLL
Sbjct: 295 TRVPEFIFQANKETQAAYLSGLFQTDGCVNANHKAKALTIELTSIHYESLQDVQKLLLNM 354
Query: 1576 GILSKIYERPYKREFKYTTKDGEERTYTTEGYYELVIANY-SRKIFAERIGLEGYKMEKL 1634
G+ + IY + + G + Y + +++ I + SR++F + ++ Y + K
Sbjct: 355 GVYTTIYSNNKRSQELLPDGKGGSKLYNVKPTHKISIQDRNSRELFMSIVEMKEYDVYKF 414
Query: 1635 SL------EKIKVDEPIVTVE--SVEILGKKLVYDFTVPEHHMYISNGFMSHNCGE---- 1682
+L K + + T E S+E G + VYD T ++H I NG ++ NC E
Sbjct: 415 NLLTETLQPKSRKPKHDFTAEIISIEEDGVEDVYDTTQEDYHSLIFNGIVTGNCSEVLQS 474
Query: 1683 ---EPLYEYE---------SCNLASINLAKFVKYDENGKPYFDWDEYAYVIQKVAKYLDN 1730
+Y+ SCNL S+N+ + Q +A +
Sbjct: 475 SQVSVYTDYDKEDEIGLDISCNLGSMNIVNVMSN-----------------QSIASTVRI 517
Query: 1731 SID--------VNKFPLPEIDYNTKLTRRIGVGMMGLADALFKLGIPYNSEEGFKFMRKV 1782
+ID N P + L R IG+G M L L + I Y SEE F
Sbjct: 518 AIDSLTTVTRKTNIVNAPAVARANTLMRSIGLGQMNLHGFLAQNNIAYESEEAKDFANTY 577
Query: 1783 TEYLTFYAYKYSIEAAKKRG-TFPLYEKTGYPKGEL---PVEGFYHPEIWNLP------- 1831
+ FY+ + S+E A++ G T+ ++ + Y GE V Y P+ +
Sbjct: 578 FMMVNFYSLQRSMEIARETGETYYKFDGSTYKSGEYFEKYVTNDYSPQYEKVKKLFGDQH 637
Query: 1832 ------WDKLVEEIKKYGVRNAMVTTCPPTGSVSMIADTSSGIEPIFALVYKKSVTVGEF 1885
W KL E++ KYG+ ++ PTGS+S + +++G+ PI + +++ +
Sbjct: 638 IPNIQDWMKLKEDVMKYGLYHSYRQAIAPTGSISYVQSSTAGVMPIMERIEERTYGNSKT 697
Query: 1886 YYVDPVFEAE 1895
YY P A+
Sbjct: 698 YYPMPGLSAQ 707
Score = 107 bits (265), Expect = 1e-21
Identities = 130/516 (25%), Positives = 206/516 (39%), Gaps = 103/516 (19%)
Query: 704 NFSKLRPEGDIVGTTTGAACFTGDTRILTEKGLIPIEEIVHETGKKPKVVTHAGLKD--- 760
N +K+ P I C TG+T +LTE G ++ ++ KVV KD
Sbjct: 64 NVNKVHPNEHISKVKFSNLCVTGETLLLTENGYEKAADL-YKKQNDLKVVIDNRTKDFAV 122
Query: 761 ----------IIETYDNGEMEVFRVTTEDGYELKVTGDHKFLVFDENGNPTLKPLKELKV 810
I + E+F+V T+ GYE++ T HKF V +G L +LK
Sbjct: 123 GSKGTTIVDAIPMQLTKKDAEIFKVKTKQGYEIRATEWHKFYV-KRDGEIQKLQLNQLKT 181
Query: 811 GDYVYILAPEWKGGEYVELDTNIELKGKGYNVNLPSKLDEKLAYLLGIIYADGHIR---- 866
GD + + + E G+ E D LAY++GII DG I
Sbjct: 182 GDKLLVQSAEGAYGKIHEPD---------------------LAYIMGIIAGDGTITEKTA 220
Query: 867 --HYFENGKRKNSKIEIYLHQDETEIKEKVKRYFKEIFGIEPKEFLKEEQHKVILVIPST 924
+ ++N K K+ +H+ K KV R +K + P + + + +L + ST
Sbjct: 221 KIYLYDNKKVLEQKVTDAVHRIIQ--KHKVDRAYKHNTSLLPTFNMANPEKQDLLYMNST 278
Query: 925 KIVKFLEINGLLKDKSENIRVPEAIFRSRPSVIAAFLAGFFDGDGSIDQNYR-----IAF 979
+ L+ G+ +K RVPE IF++ AA+L+G F DG ++ N++ I
Sbjct: 279 VLFDILKKFGM--NKETKTRVPEFIFQANKETQAAYLSGLFQTDGCVNANHKAKALTIEL 336
Query: 980 KSISREFIKEAQLLFLALGIVTSIQEYNPPNPNNKTVYTLRVQTRDMKIKAFNVLKESVK 1039
SI E +++ Q L L +G+ T+I NNK L + K +NV K + K
Sbjct: 337 TSIHYESLQDVQKLLLNMGVYTTIYS------NNKRSQELLPDGKGGS-KLYNV-KPTHK 388
Query: 1040 LSKIMKEAISKLEENGKNKKFSFPFNAIYHIKDPKIRAKIQRDYKILSYNSKVTHRAFIN 1099
+S +++ + F +I +K +Y + +N +
Sbjct: 389 IS---------IQDRNSRELFM----SIVEMK----------EYDVYKFN-------LLT 418
Query: 1100 NILKLKEELGLDDEEVKYFEMLSKLYPTKITKIEPLGKAHVYDLQVEDVHLLTGNGIYTS 1159
L+ K D + +I IE G VYD ED H L NGI T
Sbjct: 419 ETLQPKSRKPKHD------------FTAEIISIEEDGVEDVYDTTQEDYHSLIFNGIVTG 466
Query: 1160 NSGPVSFMHLIDAVSDVIKQG--GVRRGANMGILEI 1193
N V + +D K+ G+ N+G + I
Sbjct: 467 NCSEVLQSSQVSVYTDYDKEDEIGLDISCNLGSMNI 502
>dbj|BAB06529.1| (AP001516) ribonucleoside-diphosphate reductase (major subunit)
[Bacillus halodurans]
Length = 852
Score = 159 bits (398), Expect = 3e-37
Identities = 132/437 (30%), Positives = 196/437 (44%), Gaps = 70/437 (16%)
Query: 1680 CGEEPLYEYESCNLASINLAKFVKYDENGKPYFDWDEYAYVIQKVAKYLDNSIDVNKFPL 1739
CGE+PL Y CNLA+INLA+ E D+ + ++ + DN ID + L
Sbjct: 478 CGEQPLAPYSVCNLAAINLAEMANKQEKT---VDFKKLKQTVEVGVRMQDNVIDATPYFL 534
Query: 1740 PEIDYNTKLTRRIGVGMMGLADALFKLGIPYNSEEGFKFMRKVTEYLTFYAYKYSIEAAK 1799
E K RR+G+G+MGL D L Y SEEG K + ++ E + AY+ SIE AK
Sbjct: 535 EENTKQAKGERRVGLGVMGLHDLLIYTETVYGSEEGNKLVDQIFETIATTAYRTSIELAK 594
Query: 1800 KRGTFP-LYEKTGYPKGELPVEGFYHPEIWNLPWDKLVEEIKKYGVRNAMVTTCPPTGSV 1858
++G+FP L +T +L + +P D + + + +YG+RN+ + T PTGS
Sbjct: 595 EKGSFPFLVGQTDEETKQLRQRFIGTGYMKKMPED-IRQGVLEYGIRNSHLLTVAPTGST 653
Query: 1859 SMIADTSSGIEPIFALVYKKSVTVGEFYYVDPVFEAELKRRGLYSEELLKKISDNYGSVQ 1918
+ S+G+EP F+ Y +S +G+F V E R ++E
Sbjct: 654 GTMVGVSTGLEPYFSFSYFRSGRLGKFIEVKAEIVQEYLRAHPEADE------------- 700
Query: 1919 GLEEIPEDMRRVFVTALDIHWLDHLLAQANIQMWLTDSASKTINMINEATVEDVKAAYLI 1978
+PE F++ +++ H Q IQ W+ S SKT+N TVE V+A Y
Sbjct: 701 --NHLPE----WFISTMELAPEAHADVQCIIQRWVDSSLSKTVNAPRGYTVEQVQAVYER 754
Query: 1979 AHFLGCKGVTVYRDGSLSVQVYSVEGEKKRRYKPKPSEYAKKVLLEIVEKEPWIKNFINV 2038
+ G KG TVY DGS QV S++ E+ + + VL E + E K + V
Sbjct: 755 LYRGGAKGGTVYVDGSRDAQVLSLKAEE--------NTLDEDVLAETEQSE---KKIVLV 803
Query: 2039 DEILNGKRQELNFSLTGLKRETHEVKKVEVKQQNNKIPEEKIKELLGVVYCPVCYEREGK 2098
D I Q++ + + E + CPVC REG
Sbjct: 804 DTI-----QDVRTTDVTIGSEVGDT-------------------------CPVC--REGT 831
Query: 2099 LVELRMESGCATCPVCG 2115
+ +L GC TC CG
Sbjct: 832 VEDL---GGCNTCTNCG 845
>gb|AAB92484.1| (AF012906) ribonucleotide reductase homolog [Bacillus subtilis]
Length = 661
Score = 155 bits (389), Expect = 4e-36
Identities = 150/586 (25%), Positives = 254/586 (42%), Gaps = 96/586 (16%)
Query: 1385 EVARVRTKEGYEITATLDHKLMTPEGWK----EIKDLKPGDKILLPRFEVEEDFGSESIG 1440
E+ +V+TK+GYEI AT HK + ++ LK GDK+L+ E +G I
Sbjct: 18 EIFKVKTKQGYEIRATEWHKFYVKRDGEIQKLQLNQLKTGDKLLVQ--SAEGAYGK--IH 73
Query: 1441 E-DLAFVLGWFIGDGYLNVKDKRAWFYFNAEK-EEEIAWKIREILAKRFEIKAEPHRYGN 1498
E DLA+++G GDG + K + + Y N + E+++ + I+ K +A H
Sbjct: 74 EPDLAYIMGIIAGDGTITEKTAKIYLYDNKKVLEQKVTDAVHRIIQKHKVDRAYKHNTSL 133
Query: 1499 QIKLGVRGKAYE---WLESIV-----------KTNEKRIPEIVYRLKPNEIASFLRGLFS 1544
+ + ++ S V K + R+PE +++ A++L GLF
Sbjct: 134 LPTFNMANPEKQDLLYMNSTVLFDILKKFGMNKETKTRVPEFIFQANKETQAAYLSGLFQ 193
Query: 1545 ADGYVDND-----MAIRLTSKSRELLREVQDLLLLFGILSKIYERPYKREFKYTTKDGEE 1599
DG V+ + + I LTS E L++VQ LLL G+ + IY + + G
Sbjct: 194 TDGCVNANHKAKALTIELTSIHYESLQDVQKLLLNMGVYTTIYSNNKRSQELLPDGKGGS 253
Query: 1600 RTYTTEGYYELVIANY-SRKIFAERIGLEGYKMEKLSL------EKIKVDEPIVTVE--S 1650
+ Y + +++ I + SR++F + ++ Y + K +L K + + T E S
Sbjct: 254 KLYNVKPTHKISIQDRNSRELFMSIVEMKEYDVYKFNLLTETLQPKSRKPKHDFTAEIIS 313
Query: 1651 VEILGKKLVYDFTVPEHHMYISNGFMSHNCGE-------EPLYEYE---------SCNLA 1694
+E G + VYD T ++H I NG ++ NC E +Y+ SCNL
Sbjct: 314 IEEDGVEDVYDTTQEDYHSLIFNGIVTGNCSEVLQSSQVSVYTDYDKEDEIGLDISCNLG 373
Query: 1695 SINLAKFVKYDENGKPYFDWDEYAYVIQKVAKYLDNSID--------VNKFPLPEIDYNT 1746
S+N+ + Q +A + +ID N P +
Sbjct: 374 SMNIVNVMSN-----------------QSIASTVRIAIDSLTTVTRKTNIVNAPAVARAN 416
Query: 1747 KLTRRIGVGMMGLADALFKLGIPYNSEEGFKFMRKVTEYLTFYAYKYSIEAAKKRG-TFP 1805
L R IG+G M L L + I Y SEE F + FY+ + S+E A++ G T+
Sbjct: 417 TLMRSIGLGQMNLHGFLAQNNIAYESEEAKDFANTYFMMVNFYSLQRSMEIARETGETYY 476
Query: 1806 LYEKTGYPKGEL---PVEGFYHPEIWNLP-------------WDKLVEEIKKYGVRNAMV 1849
++ + Y GE V Y P+ + W KL E++ KYG+ ++
Sbjct: 477 KFDGSTYKSGEYFEKYVTNDYSPQYEKVKKLFGDQHIPNIQDWMKLKEDVMKYGLYHSYR 536
Query: 1850 TTCPPTGSVSMIADTSSGIEPIFALVYKKSVTVGEFYYVDPVFEAE 1895
PTGS+S + +++G+ PI + +++ + YY P A+
Sbjct: 537 QAIAPTGSISYVQSSTAGVMPIMERIEERTYGNSKTYYPMPGLSAQ 582
Score = 98.3 bits (241), Expect = 8e-19
Identities = 112/438 (25%), Positives = 180/438 (40%), Gaps = 89/438 (20%)
Query: 769 EMEVFRVTTEDGYELKVTGDHKFLVFDENGNPTLKPLKELKVGDYVYILAPEWKGGEYVE 828
+ E+F+V T+ GYE++ T HKF V +G L +LK GD + + + E G+ E
Sbjct: 16 DAEIFKVKTKQGYEIRATEWHKFYV-KRDGEIQKLQLNQLKTGDKLLVQSAEGAYGKIHE 74
Query: 829 LDTNIELKGKGYNVNLPSKLDEKLAYLLGIIYADGHIR------HYFENGKRKNSKIEIY 882
D LAY++GII DG I + ++N K K+
Sbjct: 75 PD---------------------LAYIMGIIAGDGTITEKTAKIYLYDNKKVLEQKVTDA 113
Query: 883 LHQDETEIKEKVKRYFKEIFGIEPKEFLKEEQHKVILVIPSTKIVKFLEINGLLKDKSEN 942
+H+ K KV R +K + P + + + +L + ST + L+ G+ +K
Sbjct: 114 VHRIIQ--KHKVDRAYKHNTSLLPTFNMANPEKQDLLYMNSTVLFDILKKFGM--NKETK 169
Query: 943 IRVPEAIFRSRPSVIAAFLAGFFDGDGSIDQNYR-----IAFKSISREFIKEAQLLFLAL 997
RVPE IF++ AA+L+G F DG ++ N++ I SI E +++ Q L L +
Sbjct: 170 TRVPEFIFQANKETQAAYLSGLFQTDGCVNANHKAKALTIELTSIHYESLQDVQKLLLNM 229
Query: 998 GIVTSIQEYNPPNPNNKTVYTLRVQTRDMKIKAFNVLKESVKLSKIMKEAISKLEENGKN 1057
G+ T+I NNK L + K +NV K + K+S +++
Sbjct: 230 GVYTTIYS------NNKRSQELLPDGKGGS-KLYNV-KPTHKIS---------IQDRNSR 272
Query: 1058 KKFSFPFNAIYHIKDPKIRAKIQRDYKILSYNSKVTHRAFINNILKLKEELGLDDEEVKY 1117
+ F +I +K +Y + +N + L+ K D
Sbjct: 273 ELFM----SIVEMK----------EYDVYKFN-------LLTETLQPKSRKPKHD----- 306
Query: 1118 FEMLSKLYPTKITKIEPLGKAHVYDLQVEDVHLLTGNGIYTSNSGPVSFMHLIDAVSDVI 1177
+ +I IE G VYD ED H L NGI T N V + +D
Sbjct: 307 -------FTAEIISIEEDGVEDVYDTTQEDYHSLIFNGIVTGNCSEVLQSSQVSVYTDYD 359
Query: 1178 KQG--GVRRGANMGILEI 1193
K+ G+ N+G + I
Sbjct: 360 KEDEIGLDISCNLGSMNI 377
>gi|6677823 ribonucleotide reductase M1 [Mus musculus] >gi|200765|gb|AAA40061.1|
(K02927) ribonucleotide reductase subunit M1 [Mus
musculus]
Length = 792
Score = 148 bits (371), Expect = 5e-34
Identities = 89/283 (31%), Positives = 149/283 (52%), Gaps = 16/283 (5%)
Query: 1687 EYESCNLASINLAKFVKYDENGKPYFDWDEYAYVIQKVAKYLDNSIDVNKFPLPEIDYNT 1746
E CNLAS+ L +V + +D+++ A V + + + L+ ID+N +P+PE +
Sbjct: 440 EVAVCNLASLALNMYVTPEHT----YDFEKLAEVTKVIVRNLNKIIDINYYPIPEAHLSN 495
Query: 1747 KLTRRIGVGMMGLADALFKLGIPYNSEEGFKFMRKVTEYLTFYAYKYSIEAAKKRGTFPL 1806
K R IG+G+ GLADA + P+ S E +++ E + + A + S E AK+ G +
Sbjct: 496 KRHRPIGIGVQGLADAFILMRYPFESPEAQLLNKQIFETIYYGALEASCELAKEYGPYET 555
Query: 1807 YEKTGYPKGELPVEGFYHPEIWNLP------WDKLVEEIKKYGVRNAMVTTCPPTGSVSM 1860
YE + KG L + +WN+ W L E+I KYG+RN+++ PT S +
Sbjct: 556 YEGSPVSKGILQYD------MWNVAPTDLWDWKPLKEKIAKYGIRNSLLIAPMPTASTAQ 609
Query: 1861 IADTSSGIEPIFALVYKKSVTVGEFYYVDPVFEAELKRRGLYSEELLKKISDNYGSVQGL 1920
I + IEP + +Y + V GEF V+P +L RGL++EE+ +I GS+Q +
Sbjct: 610 ILGNNESIEPYTSNIYTRRVLSGEFQIVNPHLLKDLTERGLWNEEMKNQIIACNGSIQSI 669
Query: 1921 EEIPEDMRRVFVTALDIHWLDHLLAQANIQMWLTDSASKTINM 1963
EIP+D+++++ T +I L A ++ S S I++
Sbjct: 670 PEIPDDLKQLYKTVWEISQKTVLKMAAERGAFIDQSQSLNIHI 712
>pir||A24050 ribonucleoside-diphosphate reductase (EC 1.17.4.1) chain M1 - mouse
Length = 792
Score = 148 bits (371), Expect = 5e-34
Identities = 89/283 (31%), Positives = 149/283 (52%), Gaps = 16/283 (5%)
Query: 1687 EYESCNLASINLAKFVKYDENGKPYFDWDEYAYVIQKVAKYLDNSIDVNKFPLPEIDYNT 1746
E CNLAS+ L +V + +D+++ A V + + + L+ ID+N +P+PE +
Sbjct: 440 EVAVCNLASLALNMYVTPEHT----YDFEKLAEVTKVIVRNLNKIIDINYYPIPEAHLSN 495
Query: 1747 KLTRRIGVGMMGLADALFKLGIPYNSEEGFKFMRKVTEYLTFYAYKYSIEAAKKRGTFPL 1806
K R IG+G+ GLADA + P+ S E +++ E + + A + S E AK+ G +
Sbjct: 496 KRHRPIGIGVQGLADAFILMRYPFESPEAQLLNKQIFETIYYGALEASCELAKEYGPYET 555
Query: 1807 YEKTGYPKGELPVEGFYHPEIWNLP------WDKLVEEIKKYGVRNAMVTTCPPTGSVSM 1860
YE + KG L + +WN+ W L E+I KYG+RN+++ PT S +
Sbjct: 556 YEGSPVSKGILQYD------MWNVAPTDLWDWKPLKEKIAKYGIRNSLLIAPMPTASTAQ 609
Query: 1861 IADTSSGIEPIFALVYKKSVTVGEFYYVDPVFEAELKRRGLYSEELLKKISDNYGSVQGL 1920
I + IEP + +Y + V GEF V+P +L RGL++EE+ +I GS+Q +
Sbjct: 610 ILGNNESIEPYTSNIYTRRVLSGEFQIVNPHLLKDLTERGLWNEEMKNQIIACNGSIQSI 669
Query: 1921 EEIPEDMRRVFVTALDIHWLDHLLAQANIQMWLTDSASKTINM 1963
EIP+D+++++ T +I L A ++ S S I++
Sbjct: 670 PEIPDDLKQLYKTVWEISQKTVLKMAAERGAFIDQSQSLNIHI 712
>pir||T35125 ribonucleotide reductase - Streptomyces coelicolor
>gi|2995313|emb|CAA18341.1| (AL022268) ribonucleotide
reductase [Streptomyces coelicolor A3(2)]
Length = 967
Score = 148 bits (370), Expect = 6e-34
Identities = 120/403 (29%), Positives = 189/403 (46%), Gaps = 36/403 (8%)
Query: 1660 YDFTVPEHHMYISNGFM--SHNCGEEPLYEYESCNLASINLAKFVKYDENGKPYFDWDEY 1717
YD T+ H +G + S+ C E + SCNLAS+NL KF+K D G FD + +
Sbjct: 344 YDDTINAWHTCPESGRINGSNPCSEYMHLDNTSCNLASLNLMKFLKDDGKGNQSFDAERF 403
Query: 1718 AYVIQKVAKYLDNSIDVNKFPLPEIDYNTKLTRRIGVGMMGLADALFKLGIPYNSEEGFK 1777
+ V++ V +D SI FP +I NT+ R++G+G L L G Y+S+ G
Sbjct: 404 SKVVELVITAMDISICFADFPTQKIGENTRAFRQLGIGYANLGALLMATGHAYDSDGGRA 463
Query: 1778 FMRKVTEYLTFYAYKYSIEAAKKRGTFPLYEKTGYPKGELPVEGFYHPE----------- 1826
+T +T +Y+ S E A G + Y + P L V + E
Sbjct: 464 LAGAITSLMTGTSYRRSAELAAIVGPYDGYARNAKP--HLRVMKQHSDENAKAVRMDDLD 521
Query: 1827 --IW---NLPWDKLVEEIKKYGVRNAMVTTCPPTGSV--SMIADTSSGIEPIFALV-YKK 1878
IW W ++ +K G RN+ + PTG++ +M DT +G+EP ALV +KK
Sbjct: 522 TPIWAAATEAWQDVLRLGEKNGFRNSQASVIAPTGTIGLAMSCDT-TGLEPDLALVKFKK 580
Query: 1879 SVTVGEFYYVDPVFEAELKRRGLYSEE---LLKKISDNYGSVQGLEEIPEDMRRVFVTAL 1935
V G V+ L+R G E+ ++ I++N G+V + + VF A+
Sbjct: 581 LVGGGSMQIVNGTVPQALRRLGYQEEQIEAIVAHIAEN-GNVIDAPGLKPEHYEVFDCAM 639
Query: 1936 ---DIHWLDHLLAQANIQMWLTDSASKTINMINEATVEDVKAAYLIAHFLGCKGVTVYRD 1992
I + H+ A IQ W++ + SKT+N+ ATVEDV+ Y A +G K + +YRD
Sbjct: 640 GERSISAMGHVRMMAAIQPWISGALSKTVNLPESATVEDVEEVYFEAWKMGVKALAIYRD 699
Query: 1993 G-----SLSVQVYSVEGEKKRRYKPKPSEYAKKVLLEIVEKEP 2030
LS + +V+ +K K ++ + ++VE P
Sbjct: 700 NCKVGQPLSAKTKTVKDTEKAEITEKTEAAIRETVEKVVEYRP 742
Score = 103 bits (254), Expect = 2e-20
Identities = 65/159 (40%), Positives = 88/159 (54%), Gaps = 23/159 (14%)
Query: 1161 SGPVSFMHLIDAVSDVIKQGGV-RRGANMGILEIWHPDIEKFIHAKEKNI---------- 1209
SGPVSFM DA + IK GG RR A M IL++ HPDIE FI K K
Sbjct: 210 SGPVSFMRGADASAGTIKSGGATRRAAKMVILDVDHPDIEDFIQTKVKEEEKIRALRDAG 269
Query: 1210 ------GTNVLS----NFNISVGIWEDFWEALKEGKKYPLINPRTGEVVKEIDPKTLFEE 1259
G ++ S N N SV + + F +A+++G K+ L + TGEV++E+D K LF +
Sbjct: 270 FDMDLGGDDITSVQYQNANNSVRVNDTFMKAVQDGGKFGLTSRMTGEVIEEVDAKALFRK 329
Query: 1260 LAYMAWAKADPGVIFFDIINRRNVLKEAKGGPIRATNPC 1298
+A AWA ADPG+ + D IN + E+ G I +NPC
Sbjct: 330 MAEAAWACADPGIQYDDTINAWHTCPES--GRINGSNPC 366
>sp|P07742|RIR1_MOUSE RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE M1 CHAIN (RIBONUCLEOTIDE
REDUCTASE LARGE CHAIN)
Length = 792
Score = 147 bits (367), Expect = 1e-33
Identities = 88/283 (31%), Positives = 149/283 (52%), Gaps = 16/283 (5%)
Query: 1687 EYESCNLASINLAKFVKYDENGKPYFDWDEYAYVIQKVAKYLDNSIDVNKFPLPEIDYNT 1746
E CNLAS+ L +V + +D+++ A V + + + L+ ID+N +P+PE +
Sbjct: 440 EVAVCNLASLALNMYVTPEHT----YDFEKLAEVTKVIVRNLNKIIDINYYPIPEAHLSN 495
Query: 1747 KLTRRIGVGMMGLADALFKLGIPYNSEEGFKFMRKVTEYLTFYAYKYSIEAAKKRGTFPL 1806
K R IG+G+ GLADA + P+ S E +++ E + + A + S E AK+ G +
Sbjct: 496 KRHRPIGIGVQGLADAFILMRYPFESPEAQLLNKQIFETIYYGALEASCELAKEYGPYET 555
Query: 1807 YEKTGYPKGELPVEGFYHPEIWNLP------WDKLVEEIKKYGVRNAMVTTCPPTGSVSM 1860
YE + KG L + +WN+ W L E+I KYG+RN+++ PT S +
Sbjct: 556 YEGSPVSKGILQYD------MWNVAPTDLWDWKPLKEKIAKYGIRNSLLIAPMPTASTAQ 609
Query: 1861 IADTSSGIEPIFALVYKKSVTVGEFYYVDPVFEAELKRRGLYSEELLKKISDNYGSVQGL 1920
I + IEP + +Y + V GEF V+P +L RGL+++E+ +I GS+Q +
Sbjct: 610 ILGNNESIEPYTSNIYTRRVLSGEFQIVNPHLLKDLTERGLWNKEMKNQIIACNGSIQSI 669
Query: 1921 EEIPEDMRRVFVTALDIHWLDHLLAQANIQMWLTDSASKTINM 1963
EIP+D+++++ T +I L A ++ S S I++
Sbjct: 670 PEIPDDLKQLYKTVWEISQKTVLKMAAERGAFIDQSQSLNIHI 712
>sp|O61065|RIR1_CRYPV RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE CHAIN (RIBONUCLEOTIDE
REDUCTASE R1 SUBUNIT)
Length = 803
Score = 147 bits (367), Expect = 1e-33
Identities = 92/280 (32%), Positives = 146/280 (51%), Gaps = 4/280 (1%)
Query: 1687 EYESCNLASINLAKFVKYDENGKPYFDWDEYAYVIQKVAKYLDNSIDVNKFPLPEIDYNT 1746
E CNLASI L KFV D+N K FD+D+ V + + + L+ IDV + L E +
Sbjct: 438 EVAVCNLASIALPKFV--DKNNKT-FDFDKLKEVTKVITRNLNKLIDVGYYSLKECKKSN 494
Query: 1747 KLTRRIGVGMMGLADALFKLGIPYNSEEGFKFMRKVTEYLTFYAYKYSIEAAKKRGTFPL 1806
R +G+G+ GLAD L +PY SE K +++ E + + A S E A+K G +
Sbjct: 495 LRHRPLGIGIQGLADCFMMLRMPYESEGAKKLNKQIFEVIYYAALDASCELAEKYGPYET 554
Query: 1807 YEKTGYPKGELPVEGF-YHPEIWNLPWDKLVEEIKKYGVRNAMVTTCPPTGSVSMIADTS 1865
Y + KG L ++ + P+ WD L + I K+G+RN+++ + PT S S I +
Sbjct: 555 YSASPESKGILQIDMWGVTPDSGLCDWDLLKDRISKHGIRNSLLISPMPTASTSQILGNN 614
Query: 1866 SGIEPIFALVYKKSVTVGEFYYVDPVFEAELKRRGLYSEELLKKISDNYGSVQGLEEIPE 1925
+EP + +Y + V GEF+ V+P +L GL+ + L + I N G +Q + IPE
Sbjct: 615 ESLEPFTSNIYHRRVLSGEFFVVNPHLLNDLLELGLWDDRLKQNIIANNGRIQNILTIPE 674
Query: 1926 DMRRVFVTALDIHWLDHLLAQANIQMWLTDSASKTINMIN 1965
D+R ++ T +I + A+ ++ S S I+M N
Sbjct: 675 DIRELYKTVWEIKQKTGIDIAADRGPYVCQSQSLNIHMEN 714
>gb|AAC12280.2| (AF043243) ribonucleotide reductase R1 subunit [Cryptosporidium
parvum]
Length = 803
Score = 146 bits (366), Expect = 2e-33
Identities = 93/280 (33%), Positives = 145/280 (51%), Gaps = 4/280 (1%)
Query: 1687 EYESCNLASINLAKFVKYDENGKPYFDWDEYAYVIQKVAKYLDNSIDVNKFPLPEIDYNT 1746
E CNLASI L KFV D+N K FD+D+ V + + + L+ IDV + L E +
Sbjct: 438 EVAVCNLASIGLPKFV--DKNNKT-FDFDKLKEVTKVITRNLNKLIDVGYYSLKECKKSN 494
Query: 1747 KLTRRIGVGMMGLADALFKLGIPYNSEEGFKFMRKVTEYLTFYAYKYSIEAAKKRGTFPL 1806
R +G+G+ GLAD L +PY SE K +++ E + + A S E A+K G +
Sbjct: 495 LRHRPLGIGIQGLADCFMMLRMPYESEGAKKLNKQIFEVIYYAALDASCELAEKYGPYET 554
Query: 1807 YEKTGYPKGELPVEGF-YHPEIWNLPWDKLVEEIKKYGVRNAMVTTCPPTGSVSMIADTS 1865
Y + KG L + + P+ WD L + I K+G+RN+++ + PT S S I +
Sbjct: 555 YSGSPASKGILQFDMWGVTPDSGLCDWDLLKDRISKHGIRNSLLISPMPTASTSQILGNN 614
Query: 1866 SGIEPIFALVYKKSVTVGEFYYVDPVFEAELKRRGLYSEELLKKISDNYGSVQGLEEIPE 1925
EP + +Y + V GEF+ V+P +L GL+ + L + I N GS+Q + IPE
Sbjct: 615 ESFEPFTSNIYHRRVLSGEFFVVNPHLLNDLLELGLWDDRLKQNIIANNGSIQNILTIPE 674
Query: 1926 DMRRVFVTALDIHWLDHLLAQANIQMWLTDSASKTINMIN 1965
D+R ++ T +I + A+ ++ S S I+M N
Sbjct: 675 DIRELYKTVWEIKQKTVIDMAADRGPYVCQSQSLNIHMEN 714
>gi|4506749 ribonucleotide reductase M1 polypeptide [Homo sapiens]
>gi|132608|sp|P23921|RIR1_HUMAN
RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE M1 CHAIN
(RIBONUCLEOTIDE REDUCTASE) >gi|107610|pir||S16680
ribonucleoside-diphosphate reductase (EC 1.17.4.1) chain
M1 - human >gi|36065|emb|CAA42118.1| (X59543) M1 subunit
of ribonucleotide reductase [Homo sapiens]
>gi|36153|emb|CAA42180.1| (X59617) large subunit
ribonucleotide reductase [Homo sapiens]
Length = 792
Score = 146 bits (364), Expect = 3e-33
Identities = 89/283 (31%), Positives = 148/283 (51%), Gaps = 16/283 (5%)
Query: 1687 EYESCNLASINLAKFVKYDENGKPYFDWDEYAYVIQKVAKYLDNSIDVNKFPLPEIDYNT 1746
E CNLAS+ L +V + +D+ + A V + V + L+ ID+N +P+PE +
Sbjct: 440 EVAVCNLASLALNMYVTSEHT----YDFKKLAEVTKVVVRNLNKIIDINYYPVPEACLSN 495
Query: 1747 KLTRRIGVGMMGLADALFKLGIPYNSEEGFKFMRKVTEYLTFYAYKYSIEAAKKRGTFPL 1806
K R IG+G+ GLADA + P+ S E +++ E + + A + S + AK++G +
Sbjct: 496 KRHRPIGIGVQGLADAFILMRYPFESAEAQLLNKQIFETIYYGALEASCDLAKEQGPYET 555
Query: 1807 YEKTGYPKGELPVEGFYHPEIWNLP------WDKLVEEIKKYGVRNAMVTTCPPTGSVSM 1860
YE + KG L + +WN+ W L E+I KYG+RN+++ PT S +
Sbjct: 556 YEGSPVSKGILQYD------MWNVTPTDLWDWKVLKEKIAKYGIRNSLLIAPMPTASTAQ 609
Query: 1861 IADTSSGIEPIFALVYKKSVTVGEFYYVDPVFEAELKRRGLYSEELLKKISDNYGSVQGL 1920
I + IEP + +Y + V GEF V+P +L RGL+ EE+ +I GS+Q +
Sbjct: 610 ILGNNESIEPYTSNIYTRRVLSGEFQIVNPHLLKDLTERGLWHEEMKNQIIACNGSIQSI 669
Query: 1921 EEIPEDMRRVFVTALDIHWLDHLLAQANIQMWLTDSASKTINM 1963
EIP+D+++++ T +I L A ++ S S I++
Sbjct: 670 PEIPDDLKQLYKTVWEISQKTVLKMAAERGAFIDQSQSLNIHI 712
>gi|11435736 ribonucleotide reductase M1 polypeptide [Homo sapiens]
Length = 792
Score = 146 bits (364), Expect = 3e-33
Identities = 89/283 (31%), Positives = 148/283 (51%), Gaps = 16/283 (5%)
Query: 1687 EYESCNLASINLAKFVKYDENGKPYFDWDEYAYVIQKVAKYLDNSIDVNKFPLPEIDYNT 1746
E CNLAS+ L +V + +D+ + A V + V + L+ ID+N +P+PE +
Sbjct: 440 EVAVCNLASLALNMYVTSEHT----YDFKKLAEVTKVVVRNLNKIIDINYYPVPEACLSN 495
Query: 1747 KLTRRIGVGMMGLADALFKLGIPYNSEEGFKFMRKVTEYLTFYAYKYSIEAAKKRGTFPL 1806
K R IG+G+ GLADA + P+ S E +++ E + + A + S + AK++G +
Sbjct: 496 KRHRPIGIGVQGLADAFILMRYPFESAEAQLLNKQIFETIYYGALEASCDLAKEQGPYET 555
Query: 1807 YEKTGYPKGELPVEGFYHPEIWNLP------WDKLVEEIKKYGVRNAMVTTCPPTGSVSM 1860
YE + KG L + +WN+ W L E+I KYG+RN+++ PT S +
Sbjct: 556 YEGSPVSKGILQYD------MWNVTPTDLWDWKVLKEKIAKYGIRNSLLIAPMPTASTAQ 609
Query: 1861 IADTSSGIEPIFALVYKKSVTVGEFYYVDPVFEAELKRRGLYSEELLKKISDNYGSVQGL 1920
I + IEP + +Y + V GEF V+P +L RGL+ EE+ +I GS+Q +
Sbjct: 610 ILGNNESIEPYTSNIYTRRVLSGEFQIVNPHLLKDLTERGLWHEEMKNQIIACNGSIQSI 669
Query: 1921 EEIPEDMRRVFVTALDIHWLDHLLAQANIQMWLTDSASKTINM 1963
EIP+D+++++ T +I L A ++ S S I++
Sbjct: 670 PEIPDDLKQLYKTVWEISQKTVLKMAAERGAFIDQSQSLNIHI 712
>gb|AAD37491.1| (AF107045) ribonucleotide reductase M1 subunit [Homo sapiens]
Length = 792
Score = 146 bits (364), Expect = 3e-33
Identities = 89/283 (31%), Positives = 148/283 (51%), Gaps = 16/283 (5%)
Query: 1687 EYESCNLASINLAKFVKYDENGKPYFDWDEYAYVIQKVAKYLDNSIDVNKFPLPEIDYNT 1746
E CNLAS+ L +V + +D+ + A V + V + L+ ID+N +P+PE +
Sbjct: 440 EVAVCNLASLALNMYVTSEHT----YDFKKLAEVTKVVVRNLNKIIDINYYPVPEACLSN 495
Query: 1747 KLTRRIGVGMMGLADALFKLGIPYNSEEGFKFMRKVTEYLTFYAYKYSIEAAKKRGTFPL 1806
K R IG+G+ GLADA + P+ S E +++ E + + A + S + AK++G +
Sbjct: 496 KRHRPIGIGVQGLADAFILMRYPFESAEAQLLNKQIFETIYYGALEASCDLAKEQGPYET 555
Query: 1807 YEKTGYPKGELPVEGFYHPEIWNLP------WDKLVEEIKKYGVRNAMVTTCPPTGSVSM 1860
YE + KG L + +WN+ W L E+I KYG+RN+++ PT S +
Sbjct: 556 YEGSPVSKGILQYD------MWNVTPTDLWDWKVLKEKIAKYGIRNSLLIAPMPTASTAQ 609
Query: 1861 IADTSSGIEPIFALVYKKSVTVGEFYYVDPVFEAELKRRGLYSEELLKKISDNYGSVQGL 1920
I + IEP + +Y + V GEF V+P +L RGL+ EE+ +I GS+Q +
Sbjct: 610 ILGNNESIEPYTSNIYTRRVLSGEFQIVNPHLLKDLTERGLWHEEMKNQIIACNGSIQSI 669
Query: 1921 EEIPEDMRRVFVTALDIHWLDHLLAQANIQMWLTDSASKTINM 1963
EIP+D+++++ T +I L A ++ S S I++
Sbjct: 670 PEIPDDLKQLYKTVWEISQKTVLKMAAERGAFIDQSQSLNIHI 712
>emb|CAA12167.1| (AJ224870) vitamin B12-dependent ribonucleotide reductase
[Streptomyces clavuligerus]
Length = 961
Score = 145 bits (363), Expect = 4e-33
Identities = 113/397 (28%), Positives = 185/397 (46%), Gaps = 27/397 (6%)
Query: 1660 YDFTVPEHHMYISNGFM--SHNCGEEPLYEYESCNLASINLAKFVKYDENGKPYFDWDEY 1717
YD T+ H +G + S+ C E + SCNLAS+NL KF+ D G FD + +
Sbjct: 344 YDDTINRWHTCPESGRINGSNPCSEYMHLDNTSCNLASLNLMKFLTDDGEGNQSFDVERF 403
Query: 1718 AYVIQKVAKYLDNSIDVNKFPLPEIDYNTKLTRRIGVGMMGLADALFKLGIPYNSEEGFK 1777
A V++ V +D SI FP +I NT+ R++G+G L L G Y+S+ G
Sbjct: 404 AKVVELVITAMDISICFADFPTQKIGENTRAFRQLGIGYANLGALLMATGHAYDSDGGRA 463
Query: 1778 FMRKVTEYLTFYAYKYSIEAAKKRGTFPLYEKTGYPKGELPVE-----------GFYHPE 1826
++ +T +Y+ S E A G + Y + P ++ +
Sbjct: 464 IAGAISSLMTGTSYRRSAELAAVVGPYDGYARNAAPHNQVMRQHADANDTAVRMDDLDTP 523
Query: 1827 IW---NLPWDKLVEEIKKYGVRNAMVTTCPPTGSV--SMIADTSSGIEPIFALV-YKKSV 1880
IW W ++ +K G RNA + PTG++ +M DT +G+EP ALV +KK V
Sbjct: 524 IWAAATETWQDVLRLGEKNGFRNAQASVIAPTGTIGLAMSCDT-TGLEPDLALVKFKKLV 582
Query: 1881 TVGEFYYVDPVFEAELKRRGLYSEELLKKISD--NYGSVQGLEEIPEDMRRVFVTAL--- 1935
G V+ L+R G +E++ + +G+V + + +VF A+
Sbjct: 583 GGGSMQIVNGTVPQALRRLGYQAEQIEAIVEHIAEHGNVLDAPGLKTEHYKVFDCAMGER 642
Query: 1936 DIHWLDHLLAQANIQMWLTDSASKTINMINEATVEDVKAAYLIAHFLGCKGVTVYRDGSL 1995
I + H+ A IQ W++ + SKT+NM ATVE+V+ Y A +G K + +YRD
Sbjct: 643 SISAMGHVRMMAAIQPWISGALSKTVNMPESATVEEVEEIYFEAWKMGVKALAIYRDNCK 702
Query: 1996 SVQVYSVEGEKKRR--YKPKPSEYAKKVLLEIVEKEP 2030
Q S + ++K + K + + + +++E P
Sbjct: 703 VGQPLSAKTKEKEQDGIAEKTEDTIRAAVEKVIEYRP 739
Score = 100 bits (247), Expect = 2e-19
Identities = 63/159 (39%), Positives = 86/159 (53%), Gaps = 23/159 (14%)
Query: 1161 SGPVSFMHLIDAVSDVIKQGGV-RRGANMGILEIWHPDIEKFIHAKEKNI---------- 1209
SGPVSFM DA + IK GG RR A M IL++ HPDIE FI K K
Sbjct: 210 SGPVSFMRGADASAGTIKSGGATRRAAKMVILDVDHPDIEGFIETKVKEEEKIRALRDAG 269
Query: 1210 ------GTNVLS----NFNISVGIWEDFWEALKEGKKYPLINPRTGEVVKEIDPKTLFEE 1259
G ++ S N N SV + ++F A++ G + L TGE+++++D K LF +
Sbjct: 270 FDMDLGGDDITSVQYQNANNSVRVNDEFMRAVESGSAFGLRARMTGEIIEQVDAKALFRK 329
Query: 1260 LAYMAWAKADPGVIFFDIINRRNVLKEAKGGPIRATNPC 1298
+A AWA ADPG+ + D INR + E+ G I +NPC
Sbjct: 330 MAQAAWACADPGIQYDDTINRWHTCPES--GRINGSNPC 366
>pir||B83502 ribonucleoside reductase, large chain PA1156 [imported] - Pseudomonas
aeruginosa (strain PAO1)
>gi|9947078|gb|AAG04545.1|AE004545_8 (AE004545)
ribonucleoside reductase, large chain [Pseudomonas
aeruginosa]
Length = 963
Score = 143 bits (358), Expect = 2e-32
Identities = 99/337 (29%), Positives = 169/337 (49%), Gaps = 25/337 (7%)
Query: 1665 PEHHMYISNGFMSHNCGEEPLY----EYESCNLASINLAKFVKYDENGKPYFDWDEYAYV 1720
P+ H+ + + S+ C E L E CNL SINL V + +GK D +
Sbjct: 574 PQQHVGVVHS--SNLCTEITLNTNKDEIAVCNLGSINL---VNHIVDGK--LDTAKLEKT 626
Query: 1721 IQKVAKYLDNSIDVNKFPLPEIDYNTKLTRRIGVGMMGLADALFKLGIPYNSEEGFKFMR 1780
++ + LDN ID+N + +P+ + R +G+G+MG DAL+ IPY S+ F
Sbjct: 627 VKTAVRMLDNVIDINYYSVPQAQNSNFKHRPVGLGIMGFQDALYLQHIPYGSDAAIAFAD 686
Query: 1781 KVTEYLTFYAYKYSIEAAKKRGTFPLYEKTGYPKGELPVE---------GFYHPEI---W 1828
+ E +++YA + S + A +RG + ++ + + +G LP++ G + E+
Sbjct: 687 QSMEAISYYAIQASCDLADERGAYQTFQGSLWSQGILPIDSEKKLIEERGAKYIEVDLSE 746
Query: 1829 NLPWDKLVEEIKKYGVRNAMVTTCPPTGSVSMIADTSSGIEPIFALVYKKSVTVGEFYYV 1888
L W L E ++K G+RN+ + PT +++ I S IEP + +Y KS GEF +
Sbjct: 747 TLDWAPLRERVQK-GIRNSNIMAIAPTATIANITGVSQSIEPTYQNLYVKSNLSGEFTVI 805
Query: 1889 DPVFEAELKRRGLYSEELLKKISDNYGSVQGLEEIPEDMRRVFVTALDIHWLDHLLAQAN 1948
+P +LK RGL+ ++ + GSVQ +E IP+D++ ++ TA ++ + A +
Sbjct: 806 NPYLVRDLKARGLWDPVMVNDLKYYDGSVQQIERIPQDLKDLYATAFEVETRWIVEAASR 865
Query: 1949 IQMWLTDSASKTINMINEATVEDVKAAYLIAHFLGCK 1985
Q W+ D A I A+ + + Y +A F G K
Sbjct: 866 RQKWI-DQAQSLNLYIAGASGKKLDVTYRMAWFRGLK 901
>pir||T51069 ribonucleoside-diphosphate reductase large chain (un-24gene)
[imported] - Neurospora crassa
>gi|9368573|emb|CAB98233.1| (AL390092)
ribonucleoside-diphosphate reductase large chain
(un-24gene) [Neurospora crassa]
Length = 929
Score = 143 bits (358), Expect = 2e-32
Identities = 91/305 (29%), Positives = 153/305 (49%), Gaps = 16/305 (5%)
Query: 1687 EYESCNLASINLAKFVKYDENGKPYFDWDEYAYVIQKVAKYLDNSIDVNKFPLPEIDYNT 1746
E CNLAS+ L+ F+ Y+ +D+ + V Q V + L+ ID+N +P+ E +
Sbjct: 440 EVAVCNLASLALSAFIDYENAS---YDFKKLHEVTQVVVRNLNKIIDINHYPVKEAHNSN 496
Query: 1747 KLTRRIGVGMMGLADALFKLGIPYNSEEGFKFMRKVTEYLTFYAYKYSIEAAKKRGTFPL 1806
R IGVG+ GLADA L +P++S+ K ++ E + A S + AK++G +
Sbjct: 497 MRHRPIGVGVQGLADAFLALRMPFDSDAASKLNIQIFETIYHAALTASCQLAKEQGPYAT 556
Query: 1807 YEKTGYPKGELPVEGFYHPEIWNLP------WDKLVEEIKKYGVRNAMVTTCPPTGSVSM 1860
YE G +G ++WN+ W L +IKKYGVRN+++ PT S S
Sbjct: 557 YE------GSPVSQGILQYDMWNVTPTNLWDWTALKADIKKYGVRNSLLLAPMPTASTSQ 610
Query: 1861 IADTSSGIEPIFALVYKKSVTVGEFYYVDPVFEAELKRRGLYSEELLKKISDNYGSVQGL 1920
I + EP + +Y++ V GEF V+P +L GL+S+ + +I GS+Q +
Sbjct: 611 ILGNNECFEPYTSNIYQRRVLAGEFQVVNPWLLRDLVEMGLWSDAMKNRIIAEGGSIQNI 670
Query: 1921 EEIPEDMRRVFVTALDIHWLDHLLAQANIQMWLTDSASKTINMINEATVEDVKAAYLIAH 1980
+ IP D++ ++ T +I + A+ ++ S S I+M E T+ + + +
Sbjct: 671 QSIPNDIKALYKTVWEISQRTIVKMAADRGAFIDQSQSLNIHM-REPTMGKITSMHFAGW 729
Query: 1981 FLGCK 1985
+G K
Sbjct: 730 KMGLK 734
>pir||T43711 ribonucleoside-diphosphate reductase (EC 1.17.4.1) large chain
[imported] - Neurospora crassa >gi|5733808|gb|AAD49743.1|
(AF171697) ribonucleotide reductase large subunit
[Neurospora crassa]
Length = 929
Score = 143 bits (358), Expect = 2e-32
Identities = 91/305 (29%), Positives = 153/305 (49%), Gaps = 16/305 (5%)
Query: 1687 EYESCNLASINLAKFVKYDENGKPYFDWDEYAYVIQKVAKYLDNSIDVNKFPLPEIDYNT 1746
E CNLAS+ L+ F+ Y+ +D+ + V Q V + L+ ID+N +P+ E +
Sbjct: 440 EVAVCNLASLALSAFIDYENAS---YDFKKLHEVTQVVVRNLNKIIDINHYPVKEAHNSN 496
Query: 1747 KLTRRIGVGMMGLADALFKLGIPYNSEEGFKFMRKVTEYLTFYAYKYSIEAAKKRGTFPL 1806
R IGVG+ GLADA L +P++S+ K ++ E + A S + AK++G +
Sbjct: 497 MRHRPIGVGVQGLADAFLALRMPFDSDAASKLNIQIFETIYHAALTASCQLAKEQGPYAT 556
Query: 1807 YEKTGYPKGELPVEGFYHPEIWNLP------WDKLVEEIKKYGVRNAMVTTCPPTGSVSM 1860
YE G +G ++WN+ W L +IKKYGVRN+++ PT S S
Sbjct: 557 YE------GSPVSQGILQYDMWNVTPTNLWDWTALKADIKKYGVRNSLLLAPMPTASTSQ 610
Query: 1861 IADTSSGIEPIFALVYKKSVTVGEFYYVDPVFEAELKRRGLYSEELLKKISDNYGSVQGL 1920
I + EP + +Y++ V GEF V+P +L GL+S+ + +I GS+Q +
Sbjct: 611 ILGNNECFEPYTSNIYQRRVLAGEFQVVNPWLLRDLVEMGLWSDAMKNRIIAEGGSIQNI 670
Query: 1921 EEIPEDMRRVFVTALDIHWLDHLLAQANIQMWLTDSASKTINMINEATVEDVKAAYLIAH 1980
+ IP D++ ++ T +I + A+ ++ S S I+M E T+ + + +
Sbjct: 671 QSIPNDIKALYKTVWEISQRTIVKMAADRGAFIDQSQSLNIHM-REPTMGKITSMHFAGW 729
Query: 1981 FLGCK 1985
+G K
Sbjct: 730 KMGLK 734
>gi|9632159 similar to Schizosaccharomyces ribonucleotide reductase M1 chain,
corresponds to Swiss-Prot Accession Number P36602
[Paramecium bursaria Chlorella virus 1]
>gi|7461870|pir||T18131 probable
ribonucleoside-diphosphate reductase (EC 1.17.4.1) large
chain - Chlorella virus PBCV-1 >gi|2447101|gb|AAC96959.1|
(U42580) similar to Schizosaccharomyces ribonucleotide
reductase M1 chain, corresponds to Swiss-Prot Accession
Number P36602 [Paramecium bursaria Chlorella virus 1]
Length = 771
Score = 143 bits (356), Expect = 3e-32
Identities = 93/300 (31%), Positives = 153/300 (51%), Gaps = 7/300 (2%)
Query: 1691 CNLASINLAKFVKYDENGKPYFDWDEYAYVIQKVAKYLDNSIDVNKFPLPEIDYNTKLTR 1750
C + S+ L +VK D+ FD+D+ ++ +AK LD SIDV +P+ E + + K R
Sbjct: 456 CVIGSVVLKNYVKNDK-----FDFDDLRKNVKILAKNLDRSIDVMSYPIKEAETSNKRRR 510
Query: 1751 RIGVGMMGLADALFKLGIPYNSEEGFKFMRKVTEYLTFYAYKYSIEAAKKRGTFPLYEKT 1810
IGVG+ GL D FKL +P++S E R++ E++ + A + S+E A+ G P +E +
Sbjct: 511 PIGVGVQGLQDVFFKLKLPFDSPEARDLNREIFEHIYYAAVEASVELAEIHGPHPTFEGS 570
Query: 1811 GYPKGELPVEGFYHPEIWNLPWDKLVEEIKKYGVRNAMVTTCPPTGSVSMIADTSSGIEP 1870
KG L + NL W L E +KK GVRN+++T PT S + I + EP
Sbjct: 571 PASKGILQYHMWDVTPKSNLDWRGLEERVKK-GVRNSLLTALMPTASTAQICGSVEAFEP 629
Query: 1871 IFALVYKKSVTVGEFYYVDPVFEAELKRRGLYSEELLKKISDNYGSVQGLEEIPEDMRRV 1930
I + +Y + GEF V+ EL RG +SE + +I N GS+Q + I ++ V
Sbjct: 630 ITSNLYSRRTLAGEFPVVNSYLVRELIERGTWSENMKNQIIANGGSIQKVIGIHPSVKAV 689
Query: 1931 FVTALDIHWLDHLLAQANIQMWLTDSASKTINMINEATVEDVKAAYLIAHFLGCKGVTVY 1990
+ TA D+ + A+ ++ + S + + + T+++V + G K + Y
Sbjct: 690 YKTAWDLSMKSVIDMAADRGAFVDQTQSMNL-FLAQPTLKNVTSMLFYGWKSGLKSLQYY 748
>emb|CAB77640.1| (AJ390500) ribonucleotide reductase large subunit [Candida albicans]
Length = 854
Score = 143 bits (356), Expect = 3e-32
Identities = 106/407 (26%), Positives = 198/407 (48%), Gaps = 17/407 (4%)
Query: 1687 EYESCNLASINLAKFVKYDENGKPYFDWDEYAYVIQKVAKYLDNSIDVNKFPLPEIDYNT 1746
E CNLASI L FV+ DE ++++D+ V + V + L+ ID N +P+PE + +
Sbjct: 440 EVAVCNLASIALPSFVENDEKST-WYNFDKLHQVTKVVTRNLNRVIDRNHYPVPEAERSN 498
Query: 1747 KLTRRIGVGMMGLADALFKLGIPYNSEEGFKFMRKVTEYLTFYAYKYSIEAAKKRGTFPL 1806
R I +G+ GLADA +L +P++S+E + ++ E + A + SIE AK+ G +
Sbjct: 499 MRHRPIALGVQGLADAFMELRLPFDSQEARELNIQIFETIYHAAVEASIELAKEEGAYET 558
Query: 1807 YEKTGYPKGELPVEGFYHP--EIWNLPWDKLVEEIKKYGVRNAMVTTCPPTGSVSMIADT 1864
Y + +G L + + E+W+ WD L +++ K+G+RN+++ PT S S I
Sbjct: 559 YPGSPASQGLLQFDLWNRKPTELWD--WDTLKQDLAKHGMRNSLLVAPMPTASTSQILGN 616
Query: 1865 SSGIEPIFALVYKKSVTVGEFYYVDPVFEAELKRRGLYSEELLKKISDNYGSVQGLEEIP 1924
+ EP + +Y + V GEF V+P +L G++++ + I N GS+Q L IP
Sbjct: 617 NECFEPYTSNIYSRRVLAGEFQIVNPYLLKDLVDLGVWNDAMKSSIIANNGSIQALPNIP 676
Query: 1925 EDMRRVFVTALDIHWLDHLLAQANIQMWLTDSASKTINMINEATVEDVKAAYLIAHFLGC 1984
++++ ++ T +I H++ A + D + I + T+ + + HF G
Sbjct: 677 DEIKALYKTVWEIS-QKHIIDMAADRAAFIDQSQSLNIHIKDPTMGKLTS----MHFYGW 731
Query: 1985 KGVTVYRDGSLSVQVYSVEGEKKRRYKPKPSEYAKKVLLEIVEKEPWIKNFINVDEILNG 2044
K + G ++ + + K +E A + + + IK ++N + +
Sbjct: 732 K--KGLKTGMYYLRTQAASAAIQFTIDQKIAETAGHTVANLDKLN--IKKYVNKGRVESE 787
Query: 2045 KRQELNFSLTGLKRETHE--VKKVEVKQQNNKIPEEK-IKELLGVVY 2088
+ + + + E V +++K + K E+K I+EL +Y
Sbjct: 788 NTSDAPYKSPSTEPTSLESSVADLKIKDEGEKPAEDKTIEELENDIY 834
>gb|AAG20478.1| (AE005120) ribonucleoside reductase large chain; NrdB1 [Halobacterium
sp. NRC-1]
Length = 804
Score = 141 bits (353), Expect = 6e-32
Identities = 90/318 (28%), Positives = 157/318 (49%), Gaps = 20/318 (6%)
Query: 1679 NCGEEPLYEYESCNLASINLAKFVKYDENGKPYFDWDEYAYVIQKVAKYLDNSIDVNKFP 1738
N EE E CNL S+NLA+ + + D ++ + ++ + LDN +D+N +P
Sbjct: 441 NTSEE---ETAVCNLGSVNLARHLDDGD-----IDREQLSETVETAMRMLDNVVDLNFYP 492
Query: 1739 LPEIDYNTKLTRRIGVGMMGLADALFKLGIPYNSEEGFKFMRKVTEYLTFYAYKYSIEAA 1798
+ + R +G+G+MG DAL ++ +P S++ + EY+ ++A S + A
Sbjct: 493 TENAERSNMRHRPVGLGVMGFHDALQQMRVPMASDDALDRADALQEYVAYHAIGASADLA 552
Query: 1799 KKRGTFPLYEKTGYPKGELPVEGFYH-----------PEIWNLPWDKLVEEIKKYGVRNA 1847
+RGT+ YE + + + P + P L W + + + +G+RN+
Sbjct: 553 AERGTYESYEGSKWDRDVFPQDTVDRLESERGREIPVPREERLDWSDVRQRVATHGMRNS 612
Query: 1848 MVTTCPPTGSVSMIADTSSGIEPIFALVYKKSVTVGEFYYVDPVFEAELKRRGLYSEELL 1907
PT ++S IA T+ IEP+++ +Y KS G+F V+ A+L+ R L++EEL
Sbjct: 613 NTMAVAPTATISTIAGTTPSIEPVYSNLYVKSNMSGDFTVVNDRLVADLEERDLWTEELR 672
Query: 1908 KKISDNYGSVQGLEEIPEDMRRVFVTALDIHWLDHLLAQANIQMWLTDSASKTINMINEA 1967
K++ + GSVQ L+ +PED++ ++ TA +I L A +W+ S S + E
Sbjct: 673 DKLTYHDGSVQELDAVPEDVQELYRTAFEIDPRHQLRLAARRGVWIDQSQSVNV-FFPET 731
Query: 1968 TVEDVKAAYLIAHFLGCK 1985
+ Y A LG K
Sbjct: 732 DGSKLSEVYQTAWELGLK 749
>sp|Q9Z6S5|RIR1_CHLPN RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE ALPHA CHAIN (RIBONUCLEOTIDE
REDUCTASE) >gi|7468537|pir||A72010
ribonucleoside-diphosphate reductase, alpha chain CP0872
[imported] - Chlamydophila pneumoniae (strains CWL029 and
AR39) >gi|4377312|gb|AAD19121.1| (AE001679)
Ribonucleoside Reductase, Large Chain [Chlamydophila
pneumoniae CWL029] >gi|7189784|gb|AAF38661.1| (AE002245)
ribonucleoside-diphosphate reductase, alpha subunit
[Chlamydophila pneumoniae AR39]
>gi|8979357|dbj|BAA99191.1| (AP002548) ribonucleoside
reductase, large chain [Chlamydophila pneumoniae J138]
Length = 1044
Score = 141 bits (352), Expect = 8e-32
Identities = 100/349 (28%), Positives = 167/349 (47%), Gaps = 25/349 (7%)
Query: 1679 NCGEEPLYEYESCNLASINLAKFVKYDENGKPYFDWDEYAYVIQKVAKYLDNSIDVNKFP 1738
NC E E CNL SINL + ++ D+ D ++ I + LDN ID+N +P
Sbjct: 676 NCSES---ETAVCNLGSINLVEHIRNDK-----LDEEKLKETISIAIRILDNVIDLNFYP 727
Query: 1739 LPEIDYNTKLTRRIGVGMMGLADALFKLGIPYNSEEGFKFMRKVTEYLTFYAYKYSIEAA 1798
PE R +G+G+MG D L++L I Y S+E +F + +E + +YA S A
Sbjct: 728 TPEAKQANLTHRAVGLGVMGFQDVLYELNISYASQEAVEFSDECSEIIAYYAILASSLLA 787
Query: 1799 KKRGTFPLYEKTGYPKGELPVE---------GFYHPEI---WNLPWDKLVEEIKKYGVRN 1846
K+RGT+ Y + + +G LP++ G ++ + W + + I+KYG+RN
Sbjct: 788 KERGTYASYSGSKWDRGYLPLDTIELLKETRGEHNVLVDTSSKKDWTPVRDTIQKYGMRN 847
Query: 1847 AMVTTCPPTGSVSMIADTSSGIEPIFALVYKKSVTVGEFYYVDPVFEAELKRRGLYSEEL 1906
+ V PT ++S I + IEP++ ++ KS GEF + +LK GL+ E+
Sbjct: 848 SQVMAIAPTATISNIIGVTQSIEPMYKHLFVKSNLSGEFTIPNTYLIKKLKELGLWDAEM 907
Query: 1907 LKKISDNYGSVQGLEEIPEDMRRVFVTALDI--HWLDHLLAQANIQMWLTDSASKTINMI 1964
L + GS+ +E IP ++++F+TA +I W+ + + Q W+ S + +
Sbjct: 908 LDDLKYFDGSLLEIERIPNHLKKLFLTAFEIEPEWI--IECTSRRQKWIDMGVSLNL-YL 964
Query: 1965 NEATVEDVKAAYLIAHFLGCKGVTVYRDGSLSVQVYSVEGEKKRRYKPK 2013
E + + YL A G K R + + S KR +P+
Sbjct: 965 AEPDGKKLSNMYLTAWKKGLKTTYYLRSQAATSVEKSFIDINKRGIQPR 1013
>gb|AAF04636.1|AF099142_4 (AF099142) large subunit of ribonucleotide reductase [white spot
syndrome virus]
Length = 848
Score = 141 bits (351), Expect = 1e-31
Identities = 96/308 (31%), Positives = 163/308 (52%), Gaps = 15/308 (4%)
Query: 1691 CNLASINLAKFVKYDE--NGKPYFDWDEYAYVIQKVAKYLDNSIDVNKFPLPEIDYNTKL 1748
CNLASI + KFVKY + +PY D+ E V++ + + LD IDVN + + + +
Sbjct: 467 CNLASIAVNKFVKYSPIPSLRPYVDYREMKRVVKIMTRNLDKVIDVNFYAVDKTRISNMK 526
Query: 1749 TRRIGVGMMGLADALFKLGIPYNSEEGFKFMRKVTEYLTFYAYKYSIEAAKKRG-TFPLY 1807
TR +G+G+ GLAD FKL IP+ SEE +++ E + + A + S E AK++G T+ L+
Sbjct: 527 TRPMGLGVQGLADLFFKLRIPFESEEAALINKRIFETIYYGALEASCEIAKEKGETYELF 586
Query: 1808 EKTGYPKG----ELPVEGFYHPEIW--NLP---WDKLVEEIKKYGVRNAMVTTCPPTGSV 1858
E + KG ++ E + +I+ +LP W++L +I KYGV N+M PT S
Sbjct: 587 EGSPLSKGIFQFDMGKENIKNRDIYFNSLPIHDWEQLRRDIMKYGVHNSMFVAPMPTAST 646
Query: 1859 SMIADTSSGIEPIFALVYKKSVTVGEFYYVDPVFEAELKRRGLYSEELLKKISDNYGSVQ 1918
+ I S EP+ + +Y ++V G F V+ EL + G ++ ++I + GS+Q
Sbjct: 647 AQILGNSESFEPLTSNMYNRNVLSGSFQVVNEYVIRELIKLGEWNSVTKQRIMASGGSIQ 706
Query: 1919 GLEEIPEDMRRVFVTALDIHWLDHLLAQANIQMWLTDSASKTINM-INEATVEDVKAAYL 1977
L IP+ + +F T +I+ IQ + ++++N+ + E + V++ +
Sbjct: 707 TLPNIPKSTKELFKTVWEIN--PRTTLDMAIQRGMFVDQAQSLNLFVEEPELSKVRSMTM 764
Query: 1978 IAHFLGCK 1985
A G K
Sbjct: 765 YAWEKGIK 772
>sp|Q03604|RIR1_CAEEL PROBABLE RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE CHAIN
(RIBONUCLEOTIDE REDUCTASE) >gi|280558|pir||S28302
ribonucleoside-diphosphate reductase (EC 1.17.4.1) large
chain - Caenorhabditis elegans
>gi|3880121|emb|CAA79574.1| (Z19158)
Ribonucleoside-disphosphate reductase large chain,
contains similarity to Pfam domain: PF00317
(Ribonucleotide reductase), Score=1288.0, E-value=0,
N=1~cDNA EST EMBL:M89209 comes from this gene~cDNA EST
yk13e12.3 comes from this gene~cDNA EST >
Length = 788
Score = 140 bits (349), Expect = 2e-31
Identities = 87/299 (29%), Positives = 151/299 (50%), Gaps = 9/299 (3%)
Query: 1687 EYESCNLASINLAKFVKYDENGKPYFDWDEYAYVIQKVAKYLDNSIDVNKFPLPEIDYNT 1746
E CNLASI L ++V ++ FD+ + A V + + + L+ IDVN +P+ E +
Sbjct: 446 EIAVCNLASIALNRYVTPEKK----FDFVKLAEVTKVITRNLNKIIDVNYYPVEEARNSN 501
Query: 1747 KLTRRIGVGMMGLADALFKLGIPYNSEEGFKFMRKVTEYLTFYAYKYSIEAAKKRGTFPL 1806
R IG+G+ GLAD + P+ S E +++ E + + A + S E A+ G +
Sbjct: 502 MRHRPIGLGVQGLADCFMLMRYPFTSAEARDLNKRIFETIYYAALEASCELAELNGPYST 561
Query: 1807 YEKTGYPKGELPVEGFYHPEIWNLPWDKLVEEIKKYGVRNAMVTTCPPTGSVSMIADTSS 1866
YE + KG+L + + W L ++I K+G+RN+++ PT S + I +
Sbjct: 562 YEGSPVSKGQLQFDMWGVTPTDQCDWATLRKKIAKHGIRNSLLMAPMPTASTAQILGNNE 621
Query: 1867 GIEPIFALVYKKSVTVGEFYYVDPVFEAELKRRGLYSEELLKKISDNYGSVQGLEEIPED 1926
IEP + +Y + V G+F V+P +L RGL+++E+ ++ N GS+Q ++ IP D
Sbjct: 622 SIEPYTSNIYSRRVLSGDFQIVNPHMLKDLVERGLWTDEMKNRLIANNGSIQNIDGIPSD 681
Query: 1927 MRRVFVTALDIHWLDHLLAQANIQMWLTDSASKTINMINEATVEDVKAAYLIAHFLGCK 1985
++ ++ T +I D + A+ ++ S S I+M + A HF G K
Sbjct: 682 IKELYRTVWEISQKDIIEMAADRGAYIDQSQSLNIHMAKPS-----YAGITSMHFYGWK 735
>emb|CAB82485.1| (AJ276618) ribonucleotide-diphosphate reductase large subunit chain
[Streptomyces coelicolor A3(2)]
Length = 791
Score = 138 bits (344), Expect = 7e-31
Identities = 84/295 (28%), Positives = 140/295 (46%), Gaps = 4/295 (1%)
Query: 1691 CNLASINLAKFVKYDENGKPYFDWDEYAYVIQKVAKYLDNSIDVNKFPLPEIDYNTKLTR 1750
CNL S+NL FV + DW+ ++ +LD +D+N +P + + R
Sbjct: 453 CNLGSVNLGAFV---DPAHGDMDWERLDATVRTAVTFLDRVVDINFYPTEQAGRSNARWR 509
Query: 1751 RIGVGMMGLADALFKLGIPYNSEEGFKFMRKVTEYLTFYAYKYSIEAAKKRGTFPLYEKT 1810
+G+G MGL D F+L +P++S E ++ E + AY+ S + A++ G P +EKT
Sbjct: 510 PVGLGAMGLQDVFFQLRLPFDSPEAKALSTRIAERIMLAAYETSADLAERNGPLPAWEKT 569
Query: 1811 GYPKGELPVEGFYHPEIWNLPWDKLVEEIKKYGVRNAMVTTCPPTGSVSMIADTSSGIEP 1870
+G L + + W W L + G+RN+M+ PT +++ IA IEP
Sbjct: 570 RTARGVLHPDHYGVEPAWPERWAALRARMATTGLRNSMLLAIAPTATIASIAGVYECIEP 629
Query: 1871 IFALVYKKSVTVGEFYYVDPVFEAELKRRGLYSEELLKKISDNYGSVQGLEEIPEDMRRV 1930
+ ++K+ GEF V+ +LKR G++ + + + GSVQG IPED+R +
Sbjct: 630 QVSNLFKRETLSGEFLQVNSYLVDDLKRLGVWDARTREALREANGSVQGFTWIPEDVRAL 689
Query: 1931 FVTALDIHWLDHLLAQANIQMWLTDSASKTINMINEATVEDVKAAYLIAHFLGCK 1985
+ TA +I L+ A + D A + T+ + + Y A G K
Sbjct: 690 YRTAWEIPQRG-LIDMAAARTPYLDQAQSLNLFLETPTIGKLSSMYAYAWKQGLK 743
>gi|9627579 K4L [Variola virus] >gi|417658|sp|P32984|RIR1_VARV
RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE CHAIN
(RIBONUCLEOTIDE REDUCTASE) >gi|419351|pir||B36843
ribonucleoside-diphosphate reductase (EC 1.17.4.1) large
chain - variola virus (strain India-1967)
>gi|7433363|pir||T28496 ribonucleoside-diphosphate
reductase (EC 1.17.4.1) large chain - variola major virus
>gi|62335|emb|CAA47558.1| (X67119) ribonucleotide
reductase (large subunit) [Variola virus]
>gi|297239|emb|CAA48999.1| (X69198) K4L [Variola virus]
>gi|438976|gb|AAA60806.1| (L22579) homolog of vaccinia
virus CDS I4L (ribonucleotide reductase, large subunit);
putative [Variola major virus] >gi|544814|gb|AAB29605.1|
K4L product [variola virus VAR, India-1967, Peptide, 771
aa] >gi|745175|prf||2015436BP K4L gene [Variola major
virus]
Length = 771
Score = 137 bits (342), Expect = 1e-30
Identities = 86/283 (30%), Positives = 146/283 (51%), Gaps = 18/283 (6%)
Query: 1687 EYESCNLASINLAKFVKYDENGKPYFDWDEYAYVIQKVAKYLDNSIDVNKFPLPEIDYNT 1746
E CNLASI L FV + FD+ + V++ + + L+ ID+N +P+PE + +
Sbjct: 440 EVAVCNLASIALNMFVIDGQ-----FDFLKLKDVVKVIVRNLNKIIDINYYPIPEAEISN 494
Query: 1747 KLTRRIGVGMMGLADALFKLGIPYNSEEGFKFMRKVTEYLTFYAYKYSIEAAKKRGTFPL 1806
K R IG+G+ GLADA L P++S E +K+ E + + A + S E A+K G +
Sbjct: 495 KRHRPIGIGVQGLADAFILLNYPFDSLEAQDLNKKIFETIYYGALEASCELAEKEGPYDT 554
Query: 1807 YEKTGYPKGELPVEGFYHPEIWNL------PWDKLVEEIKKYGVRNAMVTTCPPTGSVSM 1860
Y G G ++WN+ W+ L ++I+ YG+RN+++ PT S +
Sbjct: 555 Y------VGSYASNGILQYDLWNVVPSDLWNWEPLKDKIRTYGLRNSLLVAPMPTASTAQ 608
Query: 1861 IADTSSGIEPIFALVYKKSVTVGEFYYVDPVFEAELKRRGLYSEELLKKISDNYGSVQGL 1920
I + +EP + +Y + V GEF V+P L R L+++E+ +I + GS+Q
Sbjct: 609 ILGNNESVEPYTSNIYTRRVLSGEFQVVNPHLLRVLTERKLWNDEIKNRIMVDGGSIQN- 667
Query: 1921 EEIPEDMRRVFVTALDIHWLDHLLAQANIQMWLTDSASKTINM 1963
+PED++RV+ T +I + A+ ++ S S I++
Sbjct: 668 TNLPEDIKRVYKTIWEIPQKTIIKMAADRGAFIDQSQSMNIHI 710
>gi|9790995 I4L; putative [Vaccinia virus] >gi|132610|sp|P20503|RIR1_VACCC
RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE CHAIN
(RIBONUCLEOTIDE REDUCTASE) >gi|66400|pir||WMVZ9J
ribonucleoside-diphosphate reductase (EC 1.17.4.1) large
chain - vaccinia virus (strain Copenhagen and Ankara)
>gi|335407|gb|AAA48059.1| (M35027) I4L; putative
[Vaccinia virus] >gi|2772697|gb|AAB96436.1| (U94848)
ribonucleotide reductase, large subunit [Vaccinia virus]
Length = 771
Score = 137 bits (342), Expect = 1e-30
Identities = 86/283 (30%), Positives = 148/283 (51%), Gaps = 18/283 (6%)
Query: 1687 EYESCNLASINLAKFVKYDENGKPYFDWDEYAYVIQKVAKYLDNSIDVNKFPLPEIDYNT 1746
E CNLAS+ L FV +G+ FD+ + V++ + + L+ ID+N +P+PE + +
Sbjct: 440 EVAVCNLASVALNMFVI---DGR--FDFLKLKDVVKVIVRNLNKIIDINYYPIPEAEISN 494
Query: 1747 KLTRRIGVGMMGLADALFKLGIPYNSEEGFKFMRKVTEYLTFYAYKYSIEAAKKRGTFPL 1806
K R IG+G+ GLADA L P++S E +K+ E + + A + S E A+K G +
Sbjct: 495 KRHRPIGIGVQGLADAFILLNYPFDSLEAQDLNKKIFETIYYGALEASCELAEKEGPYDT 554
Query: 1807 YEKTGYPKGELPVEGFYHPEIWNL------PWDKLVEEIKKYGVRNAMVTTCPPTGSVSM 1860
Y G G ++WN+ W+ L ++I+ YG+RN+++ PT S +
Sbjct: 555 Y------VGSYASNGILQYDLWNVVPSDLWNWEPLKDKIRTYGLRNSLLVAPMPTASTAQ 608
Query: 1861 IADTSSGIEPIFALVYKKSVTVGEFYYVDPVFEAELKRRGLYSEELLKKISDNYGSVQGL 1920
I + +EP + +Y + V GEF V+P L R L+++E+ +I + GS+Q
Sbjct: 609 ILGNNESVEPYTSNIYTRRVLSGEFQVVNPHLLRVLTERKLWNDEIKNRIMADGGSIQN- 667
Query: 1921 EEIPEDMRRVFVTALDIHWLDHLLAQANIQMWLTDSASKTINM 1963
+PED++RV+ T +I + A+ ++ S S I++
Sbjct: 668 TNLPEDIKRVYKTIWEIPQKTIIKMAADRGAFIDQSQSMNIHI 710
>sp|P12848|RIR1_VACCV RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE CHAIN (RIBONUCLEOTIDE
REDUCTASE) >gi|335666|gb|AAB59806.1| (J03399)
ribonucleotide reductase [Vaccinia virus]
Length = 771
Score = 137 bits (342), Expect = 1e-30
Identities = 86/283 (30%), Positives = 148/283 (51%), Gaps = 18/283 (6%)
Query: 1687 EYESCNLASINLAKFVKYDENGKPYFDWDEYAYVIQKVAKYLDNSIDVNKFPLPEIDYNT 1746
E CNLAS+ L FV +G+ FD+ + V++ + + L+ ID+N +P+PE + +
Sbjct: 440 EVAVCNLASVALNMFVI---DGR--FDFLKLKDVVKVIVRNLNKIIDINYYPIPEAEISN 494
Query: 1747 KLTRRIGVGMMGLADALFKLGIPYNSEEGFKFMRKVTEYLTFYAYKYSIEAAKKRGTFPL 1806
K R IG+G+ GLADA L P++S E +K+ E + + A + S E A+K G +
Sbjct: 495 KRHRPIGIGVQGLADAFILLNYPFDSLEAQDLNKKIFETIYYGALEASCELAEKEGPYDT 554
Query: 1807 YEKTGYPKGELPVEGFYHPEIWNL------PWDKLVEEIKKYGVRNAMVTTCPPTGSVSM 1860
Y G G ++WN+ W+ L ++I+ YG+RN+++ PT S +
Sbjct: 555 Y------VGSYASNGILQYDLWNVVPSDLWNWEPLKDKIRTYGLRNSLLVAPMPTASTAQ 608
Query: 1861 IADTSSGIEPIFALVYKKSVTVGEFYYVDPVFEAELKRRGLYSEELLKKISDNYGSVQGL 1920
I + +EP + +Y + V GEF V+P L R L+++E+ +I + GS+Q
Sbjct: 609 ILGNNESVEPYTSNIYTRRVLSGEFQVVNPHLLRVLTERKLWNDEIKNRIMADGGSIQN- 667
Query: 1921 EEIPEDMRRVFVTALDIHWLDHLLAQANIQMWLTDSASKTINM 1963
+PED++RV+ T +I + A+ ++ S S I++
Sbjct: 668 TNLPEDIKRVYKTIWEIPQKTIIKMAADRGAFIDQSQSMNIHI 710
>sp|O84834|RIR1_CHLTR RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE ALPHA CHAIN (RIBONUCLEOTIDE
REDUCTASE) >gi|6578115|gb|AAC68424.2| (AE001355)
Ribonucleoside Reductase, Large Chain [Chlamydia
trachomatis]
Length = 1047
Score = 137 bits (342), Expect = 1e-30
Identities = 103/370 (27%), Positives = 175/370 (46%), Gaps = 30/370 (8%)
Query: 1679 NCGEEPLYEYESCNLASINLAKFVKYDENGKPYFDWDEYAYVIQKVAKYLDNSIDVNKFP 1738
NC E E CNL SINL + + D D ++ + I + LDN ID+N +P
Sbjct: 678 NCSET---ETAVCNLGSINLVQHIVGDG-----LDEEKLSETISIAVRMLDNVIDINFYP 729
Query: 1739 LPEIDYNTKLTRRIGVGMMGLADALFKLGIPYNSEEGFKFMRKVTEYLTFYAYKYSIEAA 1798
E R IG+G+MG DAL+KL I Y S+E +F +E +++YA + S A
Sbjct: 730 TKEAKEANFAHRAIGLGVMGFQDALYKLDISYASQEAVEFADYSSELISYYAIQASCLLA 789
Query: 1799 KKRGTFPLYEKTGYPKGELPVEGF-----YHPEIWNL--------PWDKLVEEIKKYGVR 1845
K+RGT+ Y+ + + +G LP++ Y E NL W+ + +K++G+R
Sbjct: 790 KERGTYSSYKGSKWDRGLLPIDTIQLLANYRGEA-NLQMDTSSRKDWEPIRSLVKEHGMR 848
Query: 1846 NAMVTTCPPTGSVSMIADTSSGIEPIFALVYKKSVTVGEFYYVDPVFEAELKRRGLYSEE 1905
+ + PT ++S I + IEP + ++ KS GEF + +LK+ G++ +
Sbjct: 849 HCQLMAIAPTATISNIIGVTQSIEPTYKHLFVKSNLSGEFTIPNVYLIEKLKKLGIWDAD 908
Query: 1906 LLKKISDNYGSVQGLEEIPEDMRRVFVTALDI--HWLDHLLAQANIQMWLTDSASKTINM 1963
+L + GS+ +E IP+ ++ +F+TA +I W+ + + Q W+ S +
Sbjct: 909 MLDDLKYFDGSLLEIERIPDHLKHIFLTAFEIEPEWI--IECASRRQKWIDMGQSLNL-Y 965
Query: 1964 INEATVEDVKAAYLIAHFLGCKGVTVYRDGSLSVQVYSVEGEKKRRYKP---KPSEYAKK 2020
+ + + + YL A G K R S + S KR +P K +
Sbjct: 966 LAQPDGKKLSNMYLTAWKKGLKTTYYLRSSSATTVEKSFVDINKRGIQPRWMKNKSASAG 1025
Query: 2021 VLLEIVEKEP 2030
+++E +K P
Sbjct: 1026 IIVERAKKAP 1035
>pir||D71466 probable ribonucleoside reductase, large chain - Chlamydia
trachomatis (serotype D, strain UW3/Cx)
Length = 1053
Score = 137 bits (342), Expect = 1e-30
Identities = 103/370 (27%), Positives = 175/370 (46%), Gaps = 30/370 (8%)
Query: 1679 NCGEEPLYEYESCNLASINLAKFVKYDENGKPYFDWDEYAYVIQKVAKYLDNSIDVNKFP 1738
NC E E CNL SINL + + D D ++ + I + LDN ID+N +P
Sbjct: 684 NCSET---ETAVCNLGSINLVQHIVGDG-----LDEEKLSETISIAVRMLDNVIDINFYP 735
Query: 1739 LPEIDYNTKLTRRIGVGMMGLADALFKLGIPYNSEEGFKFMRKVTEYLTFYAYKYSIEAA 1798
E R IG+G+MG DAL+KL I Y S+E +F +E +++YA + S A
Sbjct: 736 TKEAKEANFAHRAIGLGVMGFQDALYKLDISYASQEAVEFADYSSELISYYAIQASCLLA 795
Query: 1799 KKRGTFPLYEKTGYPKGELPVEGF-----YHPEIWNL--------PWDKLVEEIKKYGVR 1845
K+RGT+ Y+ + + +G LP++ Y E NL W+ + +K++G+R
Sbjct: 796 KERGTYSSYKGSKWDRGLLPIDTIQLLANYRGEA-NLQMDTSSRKDWEPIRSLVKEHGMR 854
Query: 1846 NAMVTTCPPTGSVSMIADTSSGIEPIFALVYKKSVTVGEFYYVDPVFEAELKRRGLYSEE 1905
+ + PT ++S I + IEP + ++ KS GEF + +LK+ G++ +
Sbjct: 855 HCQLMAIAPTATISNIIGVTQSIEPTYKHLFVKSNLSGEFTIPNVYLIEKLKKLGIWDAD 914
Query: 1906 LLKKISDNYGSVQGLEEIPEDMRRVFVTALDI--HWLDHLLAQANIQMWLTDSASKTINM 1963
+L + GS+ +E IP+ ++ +F+TA +I W+ + + Q W+ S +
Sbjct: 915 MLDDLKYFDGSLLEIERIPDHLKHIFLTAFEIEPEWI--IECASRRQKWIDMGQSLNL-Y 971
Query: 1964 INEATVEDVKAAYLIAHFLGCKGVTVYRDGSLSVQVYSVEGEKKRRYKP---KPSEYAKK 2020
+ + + + YL A G K R S + S KR +P K +
Sbjct: 972 LAQPDGKKLSNMYLTAWKKGLKTTYYLRSSSATTVEKSFVDINKRGIQPRWMKNKSASAG 1031
Query: 2021 VLLEIVEKEP 2030
+++E +K P
Sbjct: 1032 IIVERAKKAP 1041
>emb|CAC17629.1| (AJ295338) ribonucleotide-diphosphate reductase large chain
[Streptomyces jumonjinensis]
Length = 804
Score = 137 bits (342), Expect = 1e-30
Identities = 72/247 (29%), Positives = 124/247 (50%), Gaps = 5/247 (2%)
Query: 1691 CNLASINLAKFVKYDENGKPYFDWDEYAYVIQKVAKYLDNSIDVNKFPLPEIDYNTKLTR 1750
CNL S+NLA FV D+ DW+ ++ +LD +D+N +P + + R
Sbjct: 464 CNLGSVNLAAFVTQDD-----IDWERLDATVRTAVTFLDRVVDINFYPTEQAGRSNNRWR 518
Query: 1751 RIGVGMMGLADALFKLGIPYNSEEGFKFMRKVTEYLTFYAYKYSIEAAKKRGTFPLYEKT 1810
+G+G MGL D F+L +P++S ++ E + AY+ S + A++ G P + +T
Sbjct: 519 PVGLGAMGLQDVFFQLKLPFDSPAARTLSTRIAERIMLAAYEASADLAERHGPLPAWNET 578
Query: 1811 GYPKGELPVEGFYHPEIWNLPWDKLVEEIKKYGVRNAMVTTCPPTGSVSMIADTSSGIEP 1870
G L + + W W+ L E I G+RN+++ PT +++ IA IEP
Sbjct: 579 RTAHGVLHPDHYNTTPHWPDRWNALRERIAATGLRNSLLLAIAPTATIASIAGVYECIEP 638
Query: 1871 IFALVYKKSVTVGEFYYVDPVFEAELKRRGLYSEELLKKISDNYGSVQGLEEIPEDMRRV 1930
+ ++K+ GEF V+ ELK G++ + + D GS+Q ++P D+R +
Sbjct: 639 QVSNLFKRETLSGEFLQVNTYLVQELKNLGVWDATTREALRDANGSIQNFTQVPADVREL 698
Query: 1931 FVTALDI 1937
+ TA +I
Sbjct: 699 YRTAWEI 705
>emb|CAB94611.1| (AL359214) ribonucleotide-diphosphate reductase large chain
[Streptomyces coelicolor A3(2)]
Length = 791
Score = 137 bits (341), Expect = 2e-30
Identities = 83/295 (28%), Positives = 140/295 (47%), Gaps = 4/295 (1%)
Query: 1691 CNLASINLAKFVKYDENGKPYFDWDEYAYVIQKVAKYLDNSIDVNKFPLPEIDYNTKLTR 1750
CNL S+NL FV + DW+ ++ +LD +D+N +P + + R
Sbjct: 453 CNLGSVNLGAFV---DPAHGDMDWERLDATVRTAVTFLDRVVDINFYPTEQAGRSNARWR 509
Query: 1751 RIGVGMMGLADALFKLGIPYNSEEGFKFMRKVTEYLTFYAYKYSIEAAKKRGTFPLYEKT 1810
+G+G MGL D F+L +P++S E ++ E + AY+ S + A++ G P +EKT
Sbjct: 510 PVGLGAMGLQDVFFQLRLPFDSPEAKALSTRIAERIMLAAYETSADLAERNGPLPAWEKT 569
Query: 1811 GYPKGELPVEGFYHPEIWNLPWDKLVEEIKKYGVRNAMVTTCPPTGSVSMIADTSSGIEP 1870
+G L + + W W L + G+RN+++ PT +++ IA IEP
Sbjct: 570 RTARGVLHPDHYGVEPAWPERWAALRARMATTGLRNSLLLAIAPTATIASIAGVYECIEP 629
Query: 1871 IFALVYKKSVTVGEFYYVDPVFEAELKRRGLYSEELLKKISDNYGSVQGLEEIPEDMRRV 1930
+ ++K+ GEF V+ +LKR G++ + + + GSVQG IPED+R +
Sbjct: 630 QVSNLFKRETLSGEFLQVNSYLVDDLKRLGVWDARTREALREANGSVQGFTWIPEDVRAL 689
Query: 1931 FVTALDIHWLDHLLAQANIQMWLTDSASKTINMINEATVEDVKAAYLIAHFLGCK 1985
+ TA +I L+ A + D A + T+ + + Y A G K
Sbjct: 690 YRTAWEIPQRG-LIDMAAARTPYLDQAQSLNLFLETPTIGKLSSMYAYAWKQGLK 743
>sp|P50648|RIR1_PLAF4 RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE CHAIN (RIBONUCLEOTIDE
REDUCTASE R1 SUBUNIT) >gi|497904|gb|AAA50171.1| (U01323)
ribonucleotide reductase large subunit [Plasmodium
falciparum]
Length = 806
Score = 136 bits (340), Expect = 2e-30
Identities = 82/282 (29%), Positives = 146/282 (51%), Gaps = 16/282 (5%)
Query: 1687 EYESCNLASINLAKFVKYDENGKPYFDWDEYAYVIQKVAKYLDNSIDVNKFPLPEIDYNT 1746
E CNLASI L KFV + K F++ + + + + + LD I+ N +P+ E +
Sbjct: 438 EVAVCNLASIALCKFVDLE---KKEFNFKKLYEITKIITRNLDKIIERNYYPVKEAKTSN 494
Query: 1747 KLTRRIGVGMMGLADALFKLGIPYNSEEGFKFMRKVTEYLTFYAYKYSIEAAKKRGTFPL 1806
R IG+G+ GLAD L PY S+ + +++ E + + A + S+E A G +
Sbjct: 495 TRHRPIGIGVQGLADTFMLLRYPYESDAAKELNKRIFETMYYAALEMSVELASIHGPYES 554
Query: 1807 YEKTGYPKGELPVEGFYHPEIWNLP-------WDKLVEEIKKYGVRNAMVTTCPPTGSVS 1859
Y+ G +G ++WN WD+L +I+K+G+RN+++ PT S S
Sbjct: 555 YQ------GSPASQGILQFDMWNAKVDNKYWDWDELKAKIRKHGLRNSLLLAPMPTASTS 608
Query: 1860 MIADTSSGIEPIFALVYKKSVTVGEFYYVDPVFEAELKRRGLYSEELLKKISDNYGSVQG 1919
I + EP + +Y + V GEF+ V+P +L RGL+ E++ +++ + GS+Q
Sbjct: 609 QILGNNESFEPYTSNIYYRRVLSGEFFVVNPHLLKDLFDRGLWDEDMKQQLIAHNGSIQY 668
Query: 1920 LEEIPEDMRRVFVTALDIHWLDHLLAQANIQMWLTDSASKTI 1961
+ EIP+D++ ++ T +I + + A+ +++ S S I
Sbjct: 669 ISEIPDDLKELYKTVWEIKQKNIIDMAADRGIFIDQSQSLNI 710
>pir||A49412 ribonucleoside-diphosphate reductase (EC 1.17.4.1) large chain -
malaria parasite (Plasmodium falciparum)
Length = 847
Score = 136 bits (340), Expect = 2e-30
Identities = 82/282 (29%), Positives = 146/282 (51%), Gaps = 16/282 (5%)
Query: 1687 EYESCNLASINLAKFVKYDENGKPYFDWDEYAYVIQKVAKYLDNSIDVNKFPLPEIDYNT 1746
E CNLASI L KFV + K F++ + + + + + LD I+ N +P+ E +
Sbjct: 479 EVAVCNLASIALCKFVDLE---KKEFNFKKLYEITKIITRNLDKIIERNYYPVKEAKTSN 535
Query: 1747 KLTRRIGVGMMGLADALFKLGIPYNSEEGFKFMRKVTEYLTFYAYKYSIEAAKKRGTFPL 1806
R IG+G+ GLAD L PY S+ + +++ E + + A + S+E A G +
Sbjct: 536 TRHRPIGIGVQGLADTFMLLRYPYESDAAKELNKRIFETMYYAALEMSVELASIHGPYES 595
Query: 1807 YEKTGYPKGELPVEGFYHPEIWNLP-------WDKLVEEIKKYGVRNAMVTTCPPTGSVS 1859
Y+ G +G ++WN WD+L +I+K+G+RN+++ PT S S
Sbjct: 596 YQ------GSPASQGILQFDMWNAKVDNKYWDWDELKAKIRKHGLRNSLLLAPMPTASTS 649
Query: 1860 MIADTSSGIEPIFALVYKKSVTVGEFYYVDPVFEAELKRRGLYSEELLKKISDNYGSVQG 1919
I + EP + +Y + V GEF+ V+P +L RGL+ E++ +++ + GS+Q
Sbjct: 650 QILGNNESFEPYTSNIYYRRVLSGEFFVVNPHLLKDLFDRGLWDEDMKQQLIAHNGSIQY 709
Query: 1920 LEEIPEDMRRVFVTALDIHWLDHLLAQANIQMWLTDSASKTI 1961
+ EIP+D++ ++ T +I + + A+ +++ S S I
Sbjct: 710 ISEIPDDLKELYKTVWEIKQKNIIDMAADRGIFIDQSQSLNI 751
>sp|P36602|RIR1_SCHPO RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE CHAIN (RIBONUCLEOTIDE
REDUCTASE) >gi|2130188|pir||S62577
ribonucleoside-diphosphate reductase large chain -
fission yeast (Schizosaccharomyces pombe)
>gi|7493296|pir||T38099 ribonucleoside-diphosphate
reductase large chain - fission yeast
(Schizosaccharomyces pombe) >gi|1067207|emb|CAA91952.1|
(Z67998) ribonucleoside-diphosphate reductase large chain
[Schizosaccharomyces pombe]
Length = 811
Score = 136 bits (340), Expect = 2e-30
Identities = 83/257 (32%), Positives = 139/257 (53%), Gaps = 17/257 (6%)
Query: 1687 EYESCNLASINLAKFVKYDENGKPYFDWDEYAYVIQKVAKYLDNSIDVNKFPLPEIDYNT 1746
E CNLAS+ L F+K +GK +++ + V++ V + L+ IDVN +P+PE +
Sbjct: 440 EVAVCNLASVALPTFIK---DGK--YNFQKLHDVVKVVTRNLNKIIDVNYYPVPEARRSN 494
Query: 1747 KLTRRIGVGMMGLADALFKLGIPYNSEEGFKFMRKVTEYLTFYAYKYSIEAAKKRGTFPL 1806
R +G+G+ GLADA F L +P+ S K ++ E + A + S E A+ GT+
Sbjct: 495 MRHRPVGLGVQGLADAFFALRLPFESAGAKKLNIQIFETIYHAALEASCEIAQVEGTYES 554
Query: 1807 YEKTGYPKGELPVEGFYHPEIWNL------PWDKLVEEIKKYGVRNAMVTTCPPTGSVSM 1860
YE G +G ++WN+ W +L E+I K+G+RN+++ PT S S
Sbjct: 555 YE------GSPASQGILQYDMWNVNPTDLWDWAELKEKIAKHGIRNSLLVAPMPTASTSQ 608
Query: 1861 IADTSSGIEPIFALVYKKSVTVGEFYYVDPVFEAELKRRGLYSEELLKKISDNYGSVQGL 1920
I + EP + +Y++ V GEF V+P +L R L++E++ K+ GS+Q +
Sbjct: 609 ILGFNECFEPYTSNMYQRRVLSGEFQIVNPWLLKDLVERDLWNEDMKNKLVMLDGSIQAI 668
Query: 1921 EEIPEDMRRVFVTALDI 1937
EIP+D++ ++ T +I
Sbjct: 669 PEIPQDLKDLYKTVWEI 685
>gi|9634441 TI4L [Vaccinia virus (strain Tian Tan)] >gi|6969720|gb|AAF33932.1|
(AF095689) TI4L [Vaccinia virus (strain Tian Tan)]
Length = 771
Score = 136 bits (340), Expect = 2e-30
Identities = 86/283 (30%), Positives = 147/283 (51%), Gaps = 18/283 (6%)
Query: 1687 EYESCNLASINLAKFVKYDENGKPYFDWDEYAYVIQKVAKYLDNSIDVNKFPLPEIDYNT 1746
E CNLAS+ L FV +G+ FD+ + V++ + + L+ ID+N +P+PE + +
Sbjct: 440 EVAVCNLASVALNMFVI---DGR--FDFLKLKDVVKVIVRNLNKIIDINYYPIPEAEISN 494
Query: 1747 KLTRRIGVGMMGLADALFKLGIPYNSEEGFKFMRKVTEYLTFYAYKYSIEAAKKRGTFPL 1806
K R IG+G+ GLADA L P++S E +K+ E + + A + S E A+K G +
Sbjct: 495 KRHRPIGIGVQGLADAFILLNYPFDSLEAQDLNKKIFETIYYGALEASCELAEKEGPYDT 554
Query: 1807 YEKTGYPKGELPVEGFYHPEIWNL------PWDKLVEEIKKYGVRNAMVTTCPPTGSVSM 1860
Y G G ++WN+ W+ L ++I+ YG RN+++ PT S +
Sbjct: 555 Y------VGSYASNGILQYDLWNVVPSDLWNWEPLKDKIRTYGFRNSLLVAPMPTASTAQ 608
Query: 1861 IADTSSGIEPIFALVYKKSVTVGEFYYVDPVFEAELKRRGLYSEELLKKISDNYGSVQGL 1920
I + +EP + +Y + V GEF V+P L R L+++E+ +I + GS+Q
Sbjct: 609 ILGNNESVEPYTSNIYTRRVLSGEFQVVNPHLLRVLTERKLWNDEIKNRIMADGGSIQN- 667
Query: 1921 EEIPEDMRRVFVTALDIHWLDHLLAQANIQMWLTDSASKTINM 1963
+PED++RV+ T +I + A+ ++ S S I++
Sbjct: 668 TNLPEDIKRVYKTIWEIPQKTIIKMAADRGAFIDQSQSMNIHI 710
>pir||S34807 ribonucleoside-diphosphate reductase (EC 1.17.4.1) large chain -
fission yeast (Schizosaccharomyces pombe)
>gi|297447|emb|CAA46232.1| (X65116) ribonucleotide
reductase, large subunit [Schizosaccharomyces pombe]
Length = 811
Score = 136 bits (339), Expect = 3e-30
Identities = 82/257 (31%), Positives = 139/257 (53%), Gaps = 17/257 (6%)
Query: 1687 EYESCNLASINLAKFVKYDENGKPYFDWDEYAYVIQKVAKYLDNSIDVNKFPLPEIDYNT 1746
E CNLAS+ L F+K +GK +++ + V++ V + L+ IDVN +P+PE +
Sbjct: 440 EVAVCNLASVALPTFIK---DGK--YNFQKLHDVVKVVTRNLNKIIDVNYYPVPEARRSN 494
Query: 1747 KLTRRIGVGMMGLADALFKLGIPYNSEEGFKFMRKVTEYLTFYAYKYSIEAAKKRGTFPL 1806
R +G+G+ GLADA F L +P+ S K ++ E + A + S E A+ GT+
Sbjct: 495 MRHRPVGLGVQGLADAFFALRLPFESAGAKKLNIQIFETIYHAALEASCEIAQVEGTYES 554
Query: 1807 YEKTGYPKGELPVEGFYHPEIWNL------PWDKLVEEIKKYGVRNAMVTTCPPTGSVSM 1860
YE G ++G ++WN+ W + E+I K+G+RN+++ PT S S
Sbjct: 555 YE------GSPCIQGILQYDMWNVNPTDLWDWAEFKEKIAKHGIRNSLLVAPMPTASTSQ 608
Query: 1861 IADTSSGIEPIFALVYKKSVTVGEFYYVDPVFEAELKRRGLYSEELLKKISDNYGSVQGL 1920
I + EP + +Y++ V GEF V+P +L R L++E++ K+ GS+Q +
Sbjct: 609 ILGFNECFEPYTSNMYQRRVLSGEFQIVNPWLLKDLVERDLWNEDMKNKLVMLDGSIQAI 668
Query: 1921 EEIPEDMRRVFVTALDI 1937
EIP+D++ ++ T +I
Sbjct: 669 PEIPQDLKDLYKTVWEI 685
>prf||1913428A ribonucleotide reductase:SUBUNIT=large [Schizosaccharomyces pombe]
Length = 811
Score = 136 bits (339), Expect = 3e-30
Identities = 82/257 (31%), Positives = 139/257 (53%), Gaps = 17/257 (6%)
Query: 1687 EYESCNLASINLAKFVKYDENGKPYFDWDEYAYVIQKVAKYLDNSIDVNKFPLPEIDYNT 1746
E CNLAS+ L F+K +GK +++ + V++ V + L+ IDVN +P+PE +
Sbjct: 440 EVAVCNLASVALPTFIK---DGK--YNFQKLHDVVKVVTRNLNKIIDVNYYPVPEARRSN 494
Query: 1747 KLTRRIGVGMMGLADALFKLGIPYNSEEGFKFMRKVTEYLTFYAYKYSIEAAKKRGTFPL 1806
R +G+G+ GLADA F L +P+ S K ++ E + A + S E A+ GT+
Sbjct: 495 MRHRPVGLGVQGLADAFFALRLPFESAGAKKLNIQIFETIYHAALEASCEIAQVEGTYES 554
Query: 1807 YEKTGYPKGELPVEGFYHPEIWNL------PWDKLVEEIKKYGVRNAMVTTCPPTGSVSM 1860
YE G ++G ++WN+ W + E+I K+G+RN+++ PT S S
Sbjct: 555 YE------GSPCIQGILQYDMWNVNPTDLWDWAEFKEKIAKHGIRNSLLVAPMPTASTSQ 608
Query: 1861 IADTSSGIEPIFALVYKKSVTVGEFYYVDPVFEAELKRRGLYSEELLKKISDNYGSVQGL 1920
I + EP + +Y++ V GEF V+P +L R L++E++ K+ GS+Q +
Sbjct: 609 ILGFNECFEPYTSNMYQRRVLSGEFQIVNPWLLKDLVERDLWNEDMKNKLVMLDGSIQAI 668
Query: 1921 EEIPEDMRRVFVTALDI 1937
EIP+D++ ++ T +I
Sbjct: 669 PEIPQDLKDLYKTVWEI 685
>sp|P79732|RIR1_BRARE RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE M1 CHAIN (RIBONUCLEOTIDE
REDUCTASE PROTEIN R1 CLASS I) >gi|1695829|gb|AAB37102.1|
(U57964) ribonucleotide reductase protein R1 class Ia
[Danio rerio]
Length = 794
Score = 135 bits (337), Expect = 5e-30
Identities = 86/279 (30%), Positives = 142/279 (50%), Gaps = 8/279 (2%)
Query: 1687 EYESCNLASINLAKFVKYDENGKPYFDWDEYAYVIQKVAKYLDNSIDVNKFPLPEIDYNT 1746
E CNLASI L +V + FD+ + A V + + K L+ ID+N +P+ E + +
Sbjct: 440 EVAVCNLASIALNMYVTSERT----FDFQKLASVTKVIVKNLNKIIDINYYPVKEAENSN 495
Query: 1747 KLTRRIGVGMMGLADALFKLGIPYNSEEGFKFMRKVTEYLTFYAYKYSIEAAKKRGTFPL 1806
K R IG+G+ GLADA + P+ S E ++ E + + A + S E A + G +
Sbjct: 496 KRHRPIGIGVQGLADAFILMRFPFESTEAQLLNTQIFETIYYAALESSCELAAEYGPYQT 555
Query: 1807 YEKTGYPKGELPVEGFYHP--EIWNLPWDKLVEEIKKYGVRNAMVTTCPPTGSVSMIADT 1864
Y KG L + + ++W+ W L E+I GVRN+++ PT S + I
Sbjct: 556 YAGCPVSKGILQYDMWEKTPTDLWD--WAALKEKIANDGVRNSLLLAPMPTASTAQILGN 613
Query: 1865 SSGIEPIFALVYKKSVTVGEFYYVDPVFEAELKRRGLYSEELLKKISDNYGSVQGLEEIP 1924
+ IEP + +Y + V GEF V+P +L RGL++EE+ +I GS+Q + IP
Sbjct: 614 NESIEPYTSNIYHRRVLSGEFQIVNPHLLKDLTERGLWNEEMKNQIIAQNGSIQTIPAIP 673
Query: 1925 EDMRRVFVTALDIHWLDHLLAQANIQMWLTDSASKTINM 1963
+D++ ++ T +I L A+ ++ S S I++
Sbjct: 674 DDLKELYKTVWEISQKTILKMAADRGAYIDQSQSLNIHI 712
>pir||F81728 ribonucleoside-diphosphate reductase, alpha chain TC0214 [imported] -
Chlamydia muridarum (strain Nigg)
>gi|7190252|gb|AAF39086.1| (AE002288)
ribonucleoside-diphosphate reductase, alpha subunit
[Chlamydia muridarum]
Length = 1047
Score = 135 bits (337), Expect = 5e-30
Identities = 99/369 (26%), Positives = 170/369 (45%), Gaps = 28/369 (7%)
Query: 1679 NCGEEPLYEYESCNLASINLAKFVKYDENGKPYFDWDEYAYVIQKVAKYLDNSIDVNKFP 1738
NC E E CNL S+NL + + D D ++ + I + LDN ID+N +P
Sbjct: 678 NCSET---ETAVCNLGSVNLVQHILDDG-----LDEEKLSETISIAVRMLDNVIDINFYP 729
Query: 1739 LPEIDYNTKLTRRIGVGMMGLADALFKLGIPYNSEEGFKFMRKVTEYLTFYAYKYSIEAA 1798
E R IG+G+MG DAL+KL I Y S+E +F +E +++YA + S A
Sbjct: 730 TKEAKEANFAHRAIGLGVMGFQDALYKLDISYASQEAVEFADYSSELISYYAIQASCLLA 789
Query: 1799 KKRGTFPLYEKTGYPKGELPV------------EGFYHPEIWNLPWDKLVEEIKKYGVRN 1846
K+RGT+ Y+ + + +G LP+ + W+ + I+++G+RN
Sbjct: 790 KERGTYSSYKGSKWDRGLLPIDTIQLLANYRGKDNLQMDTSVRKDWEPIRSLIREHGMRN 849
Query: 1847 AMVTTCPPTGSVSMIADTSSGIEPIFALVYKKSVTVGEFYYVDPVFEAELKRRGLYSEEL 1906
+ PT ++S I + IEP + ++ KS GEF + +LK+ G++ ++
Sbjct: 850 CQLMAIAPTATISNIIGVTQSIEPTYKHLFVKSNLSGEFTIPNVYLIEKLKKLGIWDADM 909
Query: 1907 LKKISDNYGSVQGLEEIPEDMRRVFVTALDI--HWLDHLLAQANIQMWLTDSASKTINMI 1964
L + GS+ +E +P+ ++ +F+TA +I W+ L + Q W+ S + +
Sbjct: 910 LDDLKYFDGSLLEIERVPDHIKHIFLTAFEIEPEWI--LECASRRQKWIDMGQSLNL-YL 966
Query: 1965 NEATVEDVKAAYLIAHFLGCKGVTVYRDGSLSVQVYSVEGEKKRRYKP---KPSEYAKKV 2021
+ + + YL A G K R S + S KR +P K + +
Sbjct: 967 AQPDGKKLSNMYLTAWKKGLKTTYYLRSSSATTVEKSFVDINKRGIQPRWMKNKSASAGI 1026
Query: 2022 LLEIVEKEP 2030
++E K P
Sbjct: 1027 VVERASKTP 1035
>pir||T51813 ribonucleoside-diphosphate reductase (EC 1.17.4.1) large chain
[imported] - Arabidopsis thaliana
>gi|3661603|gb|AAC61773.1| (AF092841)
ribonucleoside-diphosphate reductase large subunit
[Arabidopsis thaliana]
Length = 816
Score = 134 bits (334), Expect = 1e-29
Identities = 91/296 (30%), Positives = 144/296 (47%), Gaps = 31/296 (10%)
Query: 1691 CNLASINLAKFVKYDENGKP-----------------YFDWDEYAYVIQKVAKYLDNSID 1733
CNLASI L +FV+ E G P YFD+++ A V V L+ ID
Sbjct: 444 CNLASIALPRFVR--EKGVPLDSHPPKLAGSLDSKNRYFDFEKLAEVTATVTVNLNKIID 501
Query: 1734 VNKFPLPEIDYNTKLTRRIGVGMMGLADALFKLGIPYNSEEGFKFMRKVTEYLTFYAYKY 1793
VN +P+ + R IG+G+ GLADA LG+P++S E + + + E + ++A K
Sbjct: 502 VNYYPVETAKTSNMRHRPIGIGVQGLADAFILLGMPFDSPEAQQLNKDIFETIYYHALKA 561
Query: 1794 SIEAAKKRGTFPLYEKTGYPKGELPVEGFYHPEIWNL------PWDKLVEEIKKYGVRNA 1847
S E A + G + Y + KG L P++WN+ W L + I K GVRN+
Sbjct: 562 STELAARLGPYETYAGSPVSKGIL------QPDMWNVIPSDRWDWAVLRDMISKNGVRNS 615
Query: 1848 MVTTCPPTGSVSMIADTSSGIEPIFALVYKKSVTVGEFYYVDPVFEAELKRRGLYSEELL 1907
++ PT S S I + EP + +Y + V GEF V+ +L GL++ L
Sbjct: 616 LLVAPMPTASTSQILGNNECFEPYTSNIYSRRVLSGEFVVVNKHLLHDLTDMGLWTPTLK 675
Query: 1908 KKISDNYGSVQGLEEIPEDMRRVFVTALDIHWLDHLLAQANIQMWLTDSASKTINM 1963
K+ + GS+ + EIP+D++ ++ T +I + A+ ++ S S I+M
Sbjct: 676 NKLINENGSIVNVAEIPDDLKAIYRTVWEIKQRTVVDMAADRGCYIDQSQSLNIHM 731
>gb|AAD20398.1| (AC007019) putative ribonucleoside-diphosphate reductase large
subunit [Arabidopsis thaliana]
Length = 816
Score = 134 bits (334), Expect = 1e-29
Identities = 91/296 (30%), Positives = 144/296 (47%), Gaps = 31/296 (10%)
Query: 1691 CNLASINLAKFVKYDENGKP-----------------YFDWDEYAYVIQKVAKYLDNSID 1733
CNLASI L +FV+ E G P YFD+++ A V V L+ ID
Sbjct: 444 CNLASIALPRFVR--EKGVPLDSHPPKLAGSLDSKNRYFDFEKLAEVTATVTVNLNKIID 501
Query: 1734 VNKFPLPEIDYNTKLTRRIGVGMMGLADALFKLGIPYNSEEGFKFMRKVTEYLTFYAYKY 1793
VN +P+ + R IG+G+ GLADA LG+P++S E + + + E + ++A K
Sbjct: 502 VNYYPVETAKTSNMRHRPIGIGVQGLADAFILLGMPFDSPEAQQLNKDIFETIYYHALKA 561
Query: 1794 SIEAAKKRGTFPLYEKTGYPKGELPVEGFYHPEIWNL------PWDKLVEEIKKYGVRNA 1847
S E A + G + Y + KG L P++WN+ W L + I K GVRN+
Sbjct: 562 STELAARLGPYETYAGSPVSKGIL------QPDMWNVIPSDRWDWAVLRDMISKNGVRNS 615
Query: 1848 MVTTCPPTGSVSMIADTSSGIEPIFALVYKKSVTVGEFYYVDPVFEAELKRRGLYSEELL 1907
++ PT S S I + EP + +Y + V GEF V+ +L GL++ L
Sbjct: 616 LLVAPMPTASTSQILGNNECFEPYTSNIYSRRVLSGEFVVVNKHLLHDLTDMGLWTPTLK 675
Query: 1908 KKISDNYGSVQGLEEIPEDMRRVFVTALDIHWLDHLLAQANIQMWLTDSASKTINM 1963
K+ + GS+ + EIP+D++ ++ T +I + A+ ++ S S I+M
Sbjct: 676 NKLINENGSIVNVAEIPDDLKAIYRTVWEIKQRTVVDMAADRGCYIDQSQSLNIHM 731
>emb|CAB90707.2| (AJ277778) ribonucleotide-diphosphate reductase large subunit chain
[Streptomyces clavuligerus]
Length = 805
Score = 134 bits (334), Expect = 1e-29
Identities = 74/247 (29%), Positives = 123/247 (48%), Gaps = 3/247 (1%)
Query: 1691 CNLASINLAKFVKYDENGKPYFDWDEYAYVIQKVAKYLDNSIDVNKFPLPEIDYNTKLTR 1750
CNL S+NL FV + DW+ ++ +LD +D+N +P + + R
Sbjct: 463 CNLGSVNLGAFV---DPAHGDMDWERLDATVRTAVTFLDRVVDINFYPTEQAGRSNARWR 519
Query: 1751 RIGVGMMGLADALFKLGIPYNSEEGFKFMRKVTEYLTFYAYKYSIEAAKKRGTFPLYEKT 1810
+G+G MGL D F+L +P++S E ++ E + AY+ S + A++ G P +EKT
Sbjct: 520 PVGLGAMGLQDVFFQLRLPFDSPEAKALSTRIAERIMLAAYETSADLAERNGPLPAWEKT 579
Query: 1811 GYPKGELPVEGFYHPEIWNLPWDKLVEEIKKYGVRNAMVTTCPPTGSVSMIADTSSGIEP 1870
+G L + + W W L + G+RN+++ PT +++ IA IEP
Sbjct: 580 RTARGVLHPDHYGVEPAWPERWAALRARMATTGLRNSLLLAIAPTATIASIAGVYECIEP 639
Query: 1871 IFALVYKKSVTVGEFYYVDPVFEAELKRRGLYSEELLKKISDNYGSVQGLEEIPEDMRRV 1930
+ ++K+ GEF V+ LKR G++ + + + GSVQG IPED+R +
Sbjct: 640 QVSNLFKRETLSGEFLQVNSYLVDALKRLGVWDARTREALREANGSVQGFPWIPEDVRAL 699
Query: 1931 FVTALDI 1937
+ TA I
Sbjct: 700 YRTAWKI 706
>gi|9633253 L4L protein [variola minor virus] >gi|7519872|pir||H72157 L4L protein
- variola minor virus (strain Garcia-1966)
>gi|1143665|emb|CAA53832.1| (X76263) ORF3L [Variola
virus] >gi|5830619|emb|CAB54658.1| (Y16780) L4L protein
[variola minor virus]
Length = 771
Score = 134 bits (333), Expect = 1e-29
Identities = 85/283 (30%), Positives = 145/283 (51%), Gaps = 18/283 (6%)
Query: 1687 EYESCNLASINLAKFVKYDENGKPYFDWDEYAYVIQKVAKYLDNSIDVNKFPLPEIDYNT 1746
E CNLASI L FV + FD+ + V++ + + L+ ID+N +P+PE + +
Sbjct: 440 EVAVCNLASIALNMFVIDGQ-----FDFLKLKDVVKVIVRNLNKIIDINYYPIPEAEISN 494
Query: 1747 KLTRRIGVGMMGLADALFKLGIPYNSEEGFKFMRKVTEYLTFYAYKYSIEAAKKRGTFPL 1806
K R IG+G+ GLA A L P++S E +K+ E + + A + S E A+K G +
Sbjct: 495 KRHRPIGIGVQGLAYAFILLNYPFDSLEAQDLNKKIFETIYYGALEASCELAEKEGPYDT 554
Query: 1807 YEKTGYPKGELPVEGFYHPEIWNL------PWDKLVEEIKKYGVRNAMVTTCPPTGSVSM 1860
Y G G ++WN+ W+ L ++I+ YG+RN+++ PT S +
Sbjct: 555 Y------VGSYASNGILQYDLWNVVPSDLWNWEPLKDKIRTYGLRNSLLVAPMPTASTAQ 608
Query: 1861 IADTSSGIEPIFALVYKKSVTVGEFYYVDPVFEAELKRRGLYSEELLKKISDNYGSVQGL 1920
I + +EP + +Y + V GEF V+P L R L+++E+ +I + GS+Q
Sbjct: 609 ILGNNESVEPYTSNIYTRRVLSGEFQVVNPHLLRVLTERKLWNDEIKNRIMVDGGSIQN- 667
Query: 1921 EEIPEDMRRVFVTALDIHWLDHLLAQANIQMWLTDSASKTINM 1963
+PED++RV+ T +I + A+ ++ S S I++
Sbjct: 668 TNLPEDIKRVYKTIWEIPQKTIIKMAADRGAFIDQSQSMNIHI 710
>sp|O66503|RIR1_AQUAE RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE ALPHA CHAIN (RIBONUCLEOTIDE
REDUCTASE) >gi|7433360|pir||D70309
ribonucleoside-diphosphate reductase (EC 1.17.4.1) alpha
chain [similarity] - Aquifex aeolicus
>gi|2982838|gb|AAC06460.1| (AE000673) ribonucleotide
reductase alpha chain [Aquifex aeolicus]
Length = 801
Score = 133 bits (332), Expect = 2e-29
Identities = 81/206 (39%), Positives = 111/206 (53%), Gaps = 16/206 (7%)
Query: 1691 CNLASINLAKFVKYDENGKPYFDWDEYAYVIQKVAKYLDNSIDVNKFPLPEIDYNTKLTR 1750
CNL S+NL K V +E E V+ + + LDN I++N + +PE +Y K R
Sbjct: 521 CNLGSVNLGK-VHTEE---------EIKEVLPLLVRMLDNVIEMNFYAIPEAEYTNKRYR 570
Query: 1751 RIGVGMMGLADALFKLGIPYNSEEGFKFMRKVTEYLTFYAYKYSIEAAKKRGTFPLYEKT 1810
IG+G+ L K GI + SEE KF K+ E + FYA K S+E AK+RG + L++ +
Sbjct: 571 AIGIGVSNYHYCLVKNGIKWESEEHLKFADKLFELIAFYALKGSLELAKERGRYKLFDGS 630
Query: 1811 GYPKGEL------PVEGFYHPEIWNLPWDKLVEEIKKYGVRNAMVTTCPPTGSVSMIADT 1864
+ KG L +E NLPW +L EEIKKYG+RNA + PTGS S+I
Sbjct: 631 NWSKGILFGRSVEEIEENSRQNGNNLPWRELAEEIKKYGIRNAYLLALMPTGSTSLILGA 690
Query: 1865 SSGIEPIFALVYKKSVTVGEFYYVDP 1890
+ I+PIFA YK+ G V P
Sbjct: 691 TPSIDPIFARFYKEENMSGILPQVPP 716
>emb|CAC17631.1| (AJ295339) ribonucleotide-diphosphate reductase large chain
[Streptomyces lipmanii]
Length = 786
Score = 133 bits (332), Expect = 2e-29
Identities = 80/295 (27%), Positives = 140/295 (47%), Gaps = 4/295 (1%)
Query: 1691 CNLASINLAKFVKYDENGKPYFDWDEYAYVIQKVAKYLDNSIDVNKFPLPEIDYNTKLTR 1750
CNL S+ L FV + DW+ ++ +LD +D+N +P + + R
Sbjct: 447 CNLGSVKLGAFV---DTASGELDWERLDATVRTAVTFLDRVVDINFYPTEQAGRSNSRWR 503
Query: 1751 RIGVGMMGLADALFKLGIPYNSEEGFKFMRKVTEYLTFYAYKYSIEAAKKRGTFPLYEKT 1810
+G+G MGL D F+L +P++S E +++E + AY+ S + A++ G P ++KT
Sbjct: 504 PVGLGAMGLQDVFFQLKLPFDSAEARALSTRISERIMLAAYEASADLAERNGPLPAWDKT 563
Query: 1811 GYPKGELPVEGFYHPEIWNLPWDKLVEEIKKYGVRNAMVTTCPPTGSVSMIADTSSGIEP 1870
+G L + + W W L I + G+RN+++ PT +++ IA IEP
Sbjct: 564 RTARGVLHHDHYDVELTWPERWAALRARIAEVGMRNSLLLAIAPTATIASIAGVYECIEP 623
Query: 1871 IFALVYKKSVTVGEFYYVDPVFEAELKRRGLYSEELLKKISDNYGSVQGLEEIPEDMRRV 1930
+ ++K+ GEF V+ ELKR G++ E + + ++ GSVQ +P + R +
Sbjct: 624 QVSNLFKRETLSGEFLQVNAYLVDELKRLGVWDAETREALRESSGSVQDFAWVPAETRAL 683
Query: 1931 FVTALDIHWLDHLLAQANIQMWLTDSASKTINMINEATVEDVKAAYLIAHFLGCK 1985
+ TA +I L+ A + D A + T+ + + Y A G K
Sbjct: 684 YRTAWEIPQRG-LIDMAAARTPFLDQAQSLNLFMETPTIGKLSSMYAYAWKQGLK 737
>pir||WZVZH4 ribonucleoside-diphosphate reductase (EC 1.17.4.1) large chain -
vaccinia virus (strain WR)
Length = 771
Score = 132 bits (328), Expect = 5e-29
Identities = 84/283 (29%), Positives = 146/283 (50%), Gaps = 18/283 (6%)
Query: 1687 EYESCNLASINLAKFVKYDENGKPYFDWDEYAYVIQKVAKYLDNSIDVNKFPLPEIDYNT 1746
E CNLAS+ L FV +G+ FD+ + V++ + + L+ ID+N +P+PE + +
Sbjct: 440 EVAVCNLASVALNMFVI---DGR--FDFLKLKVVVKVIVRNLNKIIDINYYPIPEAEISN 494
Query: 1747 KLTRRIGVGMMGLADALFKLGIPYNSEEGFKFMRKVTEYLTFYAYKYSIEAAKKRGTFPL 1806
K R IG+G+ GLADA L P++S E +K+ E + + A + S E A+K G +
Sbjct: 495 KRHRPIGIGVQGLADAFILLNYPFDSLEAQDINKKIFETIYYGALEASCELAEKEGPYDT 554
Query: 1807 YEKTGYPKGELPVEGFYHPEIWNL------PWDKLVEEIKKYGVRNAMVTTCPPTGSVSM 1860
Y G G ++WN+ W+ L ++I+ YG+RN+++ P +
Sbjct: 555 Y------VGSYASNGILQYDLWNVVPSDLWNWEPLKDKIRTYGLRNSLLVAPLPLHQHAQ 608
Query: 1861 IADTSSGIEPIFALVYKKSVTVGEFYYVDPVFEAELKRRGLYSEELLKKISDNYGSVQGL 1920
I + +EP + +Y + V GEF V+P L R L+++E+ +I + GS+Q
Sbjct: 609 ILGNNESVEPYTSNIYTRRVLSGEFQVVNPHLLRVLTERKLWNDEIKNRIMADGGSIQN- 667
Query: 1921 EEIPEDMRRVFVTALDIHWLDHLLAQANIQMWLTDSASKTINM 1963
+PED++RV+ T +I + A+ ++ S S I++
Sbjct: 668 TNLPEDIKRVYKTIWEIPQKTIIKMAADRGAFIDQSQSMNIHI 710
>gi|9634360 ORF139 ribonucleotide reductase large subunit (rr1) [Spodoptera
exigua nucleopolyhedrovirus] >gi|6960598|gb|AAF33668.1|
(AF169823) ORF139 ribonucleotide reductase large subunit
(rr1) [Spodoptera exigua nucleopolyhedrovirus]
Length = 770
Score = 132 bits (328), Expect = 5e-29
Identities = 91/272 (33%), Positives = 135/272 (49%), Gaps = 16/272 (5%)
Query: 1677 SHNCGEEPLY----EYESCNLASINLAKFVKYDENGKPYFDWDEYAYVIQKVAKYLDNSI 1732
S+ C E Y E CNLASI + K V D FD+ ++ + + + L+ I
Sbjct: 410 SNLCAEIVQYCDENETAVCNLASIAVNKCVDVDAKT---FDYVLLKHLTKIIVRNLNKII 466
Query: 1733 DVNKFPLPEIDYNTKLTRRIGVGMMGLADALFKLGIPYNSEEGFKFMRKVTEYLTFYAYK 1792
DVN +P E + + K R IGVG+ GLADA L I Y+S++ + E + F A +
Sbjct: 467 DVNHYPTAESERSNKKHRPIGVGIQGLADAFVLLDIAYDSDDARFVNYSIAETIYFAALE 526
Query: 1793 YSIEAAKKRGTFPLYEKTGYPKGELPVE------GFYHPE-IWNLPWDKLVEEIKKYGVR 1845
S E AK G + Y + +G L G YH +W+ W++L I KYGVR
Sbjct: 527 ASCELAKINGPYESYTDSPVSRGILHFHNYDDENGVYHSNNLWD--WNELQCNINKYGVR 584
Query: 1846 NAMVTTCPPTGSVSMIADTSSGIEPIFALVYKKSVTVGEFYYVDPVFEAELKRRGLYSEE 1905
N+++ PT + + I + EP + VY + V GEF V+ L +Y+ E
Sbjct: 585 NSLLVAYMPTATTAQILGNNESFEPFTSNVYLRRVLAGEFQVVNQYLVKALIDLDIYTPE 644
Query: 1906 LLKKISDNYGSVQGLEEIPEDMRRVFVTALDI 1937
L KI GSVQ ++EIP+ ++ +F TA +I
Sbjct: 645 LRNKILAENGSVQNIDEIPQHVKNLFKTAWEI 676
>gb|AAD33590.1|AF132143_1 (AF132143) ribonucleoside reductase M1 subunit [Drosophila
melanogaster]
Length = 812
Score = 131 bits (327), Expect = 7e-29
Identities = 84/279 (30%), Positives = 140/279 (50%), Gaps = 8/279 (2%)
Query: 1687 EYESCNLASINLAKFVKYDENGKPYFDWDEYAYVIQKVAKYLDNSIDVNKFPLPEIDYNT 1746
E CNLASI L FV ++ +D+ + V + V K L+ ID+N +PLPE +
Sbjct: 451 EIAVCNLASIALNMFVTPEKT----YDFKKLKEVTKIVTKNLNKIIDINYYPLPEARKSN 506
Query: 1747 KLTRRIGVGMMGLADALFKLGIPYNSEEGFKFMRKVTEYLTFYAYKYSIEAAKKRGTFPL 1806
R +G+G+ G ADAL + PY SEE +++ E + + A + S E A+ G +
Sbjct: 507 LRHRPVGIGIQGFADALILMRFPYESEEAGLLNQQIFETIYYGALEASCELAQTEGPYET 566
Query: 1807 YEKTGYPKGELPVEGF--YHPEIWNLPWDKLVEEIKKYGVRNAMVTTCPPTGSVSMIADT 1864
YE + KG L + + +W+ W KL E I+ +GVRN+++ PT S + I
Sbjct: 567 YEGSPVSKGILQYDMWDKVPTNLWD--WQKLKESIRMHGVRNSLLVAPMPTASTAQIMGN 624
Query: 1865 SSGIEPIFALVYKKSVTVGEFYYVDPVFEAELKRRGLYSEELLKKISDNYGSVQGLEEIP 1924
+ EP +Y + V GEF V+ +L L+ +++ +I + GS+Q +E IP
Sbjct: 625 NESFEPYTTNIYTRRVLSGEFQVVNHHLLRDLTELDLWDDDMKNQIISSRGSIQNIETIP 684
Query: 1925 EDMRRVFVTALDIHWLDHLLAQANIQMWLTDSASKTINM 1963
+R ++ T +I + A+ ++ S S I++
Sbjct: 685 PKVRDLYKTVWEISVKSTIKMAADRGAFIDQSQSFNIHV 723
>gb|AAF52913.1| (AE003628) RnrL gene product [Drosophila melanogaster]
Length = 771
Score = 131 bits (327), Expect = 7e-29
Identities = 84/279 (30%), Positives = 140/279 (50%), Gaps = 8/279 (2%)
Query: 1687 EYESCNLASINLAKFVKYDENGKPYFDWDEYAYVIQKVAKYLDNSIDVNKFPLPEIDYNT 1746
E CNLASI L FV ++ +D+ + V + V K L+ ID+N +PLPE +
Sbjct: 410 EIAVCNLASIALNMFVTPEKT----YDFKKLKEVTKIVTKNLNKIIDINYYPLPEARKSN 465
Query: 1747 KLTRRIGVGMMGLADALFKLGIPYNSEEGFKFMRKVTEYLTFYAYKYSIEAAKKRGTFPL 1806
R +G+G+ G ADAL + PY SEE +++ E + + A + S E A+ G +
Sbjct: 466 LRHRPVGIGIQGFADALILMRFPYESEEAGLLNQQIFETIYYGALEASCELAQTEGPYET 525
Query: 1807 YEKTGYPKGELPVEGF--YHPEIWNLPWDKLVEEIKKYGVRNAMVTTCPPTGSVSMIADT 1864
YE + KG L + + +W+ W KL E I+ +GVRN+++ PT S + I
Sbjct: 526 YEGSPVSKGILQYDMWDKVPTNLWD--WQKLKESIRMHGVRNSLLVAPMPTASTAQIMGN 583
Query: 1865 SSGIEPIFALVYKKSVTVGEFYYVDPVFEAELKRRGLYSEELLKKISDNYGSVQGLEEIP 1924
+ EP +Y + V GEF V+ +L L+ +++ +I + GS+Q +E IP
Sbjct: 584 NESFEPYTTNIYTRRVLSGEFQVVNHHLLRDLTELDLWDDDMKNQIISSRGSIQNIETIP 643
Query: 1925 EDMRRVFVTALDIHWLDHLLAQANIQMWLTDSASKTINM 1963
+R ++ T +I + A+ ++ S S I++
Sbjct: 644 PKVRDLYKTVWEISVKSTIKMAADRGAFIDQSQSFNIHV 682
>gb|AAA48274.1| (M20299) Vaccinia virus matrix 1 protein
Length = 771
Score = 130 bits (324), Expect = 2e-28
Identities = 83/283 (29%), Positives = 145/283 (50%), Gaps = 18/283 (6%)
Query: 1687 EYESCNLASINLAKFVKYDENGKPYFDWDEYAYVIQKVAKYLDNSIDVNKFPLPEIDYNT 1746
E CNL S+ L FV +G+ FD+ + V++ + + L+ ID+N +P+PE + +
Sbjct: 440 EVAVCNLGSVALNMFVI---DGR--FDFLKLKVVVKVIVRNLNKIIDINYYPIPEAEISN 494
Query: 1747 KLTRRIGVGMMGLADALFKLGIPYNSEEGFKFMRKVTEYLTFYAYKYSIEAAKKRGTFPL 1806
K R IG+G+ GLADA L P++S E +K+ E + + A + S E A+K G +
Sbjct: 495 KRHRPIGIGVQGLADAFILLNYPFDSLEAQDINKKIFETIYYGALEASCELAEKEGPYDT 554
Query: 1807 YEKTGYPKGELPVEGFYHPEIWNL------PWDKLVEEIKKYGVRNAMVTTCPPTGSVSM 1860
Y G G ++WN+ W+ L ++I+ YG+RN+++ P +
Sbjct: 555 Y------VGSYASNGILQYDLWNVVPSDLWNWEPLKDKIRTYGLRNSLLVAPLPLHQHAQ 608
Query: 1861 IADTSSGIEPIFALVYKKSVTVGEFYYVDPVFEAELKRRGLYSEELLKKISDNYGSVQGL 1920
I + +EP + +Y + V GEF V+P L R L+++E+ +I + GS+Q
Sbjct: 609 ILGNNESVEPYTSNIYTRRVLSGEFQVVNPHLLRVLTERKLWNDEIKNRIMADGGSIQN- 667
Query: 1921 EEIPEDMRRVFVTALDIHWLDHLLAQANIQMWLTDSASKTINM 1963
+PED++RV+ T +I + A+ ++ S S I++
Sbjct: 668 TNLPEDIKRVYKTIWEIPQKTIIKMAADRGAFIDQSQSMNIHI 710
>sp|O15909|RIR1_TRYBB RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE CHAIN (RIBONUCLEOTIDE
REDUCTASE R1 SUBUNIT) >gi|2411477|gb|AAB70704.1| (U80910)
ribonucleotide reductase large subunit [Trypanosoma
brucei]
Length = 838
Score = 129 bits (321), Expect = 3e-28
Identities = 98/350 (28%), Positives = 165/350 (47%), Gaps = 24/350 (6%)
Query: 1687 EYESCNLASINLAKFVKYDENGKPYFDWDEYAYVIQKVAKYLDNSIDVNKFPLPEIDYNT 1746
E CNLASI L +FVK FD+ V + V + L+ ID N +P+ E Y+
Sbjct: 450 EVAVCNLASIALPRFVKDGA-----FDYVALKEVTKVVTRNLNRVIDRNHYPVCEARYSN 504
Query: 1747 KLTRRIGVGMMGLADALFKLGIPYNSEEGFKFMRKVTEYLTFYAYKYSIEAAKKRGTFPL 1806
R +G+G+ GLADA L +P+ E K R++ E + A + S E A+K G +
Sbjct: 505 LRHRPVGIGVQGLADAFALLSLPFAHPEAKKLNRQIFETIYIAAVEASTELAEKDGPYET 564
Query: 1807 YEKTGYPKGELPVEGF---------------YHPEIWNLPWDKLVEEIKKYGVRNAMVTT 1851
++ + +G+L + + H +W+ WD L E + K G+RN+++
Sbjct: 565 FKGSPASEGKLQFDLWDEERRIRGMNEDSVHSHCGLWD--WDSLKERVVKVGMRNSLLIA 622
Query: 1852 CPPTGSVSMIADTSSGIEPIFALVYKKSVTVGEFYYVDPVFEAELKRRGLYSEELLKKIS 1911
PT S S I + IEP + +Y + V GEF V+ EL R L+++++ +KI
Sbjct: 623 PMPTASTSQILGNNECIEPFTSNIYVRRVLSGEFPVVNKHLVKELIRLRLWNDDMRRKII 682
Query: 1912 DNYGSVQGLEEIPEDMRRVFVTALDIHWLDHLLAQANIQMWLTDSASKTINMINEATVED 1971
GSV G++EIPE +R ++ +I D + A+ ++ S S + + T
Sbjct: 683 ALNGSVSGIKEIPERIRELYKVVWEIRQKDLIDMAADRGRYIDQSQSLNL-FLATPTSSQ 741
Query: 1972 VKAAYLIAHFLGCK-GVTVYRDGSLSVQVYSVEGEKKRRYKPKPSEYAKK 2020
+ + + + G K G+ R + + K + PKP + +K+
Sbjct: 742 LTSMHFYSWKKGLKTGMYYLRSQPAADAIKFTLDPKAMKELPKPDKQSKE 791
>emb|CAA67423.1| (X98924) ribonucleotide reductase [Spodoptera littoralis nuclear
polyhedrosis virus]
Length = 781
Score = 129 bits (320), Expect = 4e-28
Identities = 79/280 (28%), Positives = 142/280 (50%), Gaps = 8/280 (2%)
Query: 1687 EYESCNLASINLAKFVKYDENGKPYFDWDEYAYVIQKVAKYLDNSIDVNKFPLPEIDYNT 1746
E CNLASI + KFV +D++ + + + L+ ID N+ PL E + +
Sbjct: 439 EVAVCNLASIAVNKFVAPQPG---VYDFERLKEITKSCDRNLNRIIDANQCPLREAERSN 495
Query: 1747 KLTRRIGVGMMGLADALFKLGIPYNSEEGFKFMRKVTEYLTFYAYKYSIEAAKKRGTFPL 1806
+ R IG+G+ G+ADA + +P+ S+ + +K+ E + + A + + E A K G +
Sbjct: 496 QRNRPIGIGVQGMADAFVTMRMPFESDAAAELNKKIFETIFYGALEANCELAAKDGPYET 555
Query: 1807 YEKTGYPKGELPVE---GFYHPEIWNLPWDKLVEEIKKYGVRNAMVTTCPPTGSVSMIAD 1863
Y+ + +GEL + G +W+ W L +I KYG+RN+++ PT S + I
Sbjct: 556 YKGSPASRGELQYDMWNGATPSNLWD--WSLLKSKISKYGLRNSLLLAPMPTASTAQILG 613
Query: 1864 TSSGIEPIFALVYKKSVTVGEFYYVDPVFEAELKRRGLYSEELLKKISDNYGSVQGLEEI 1923
+ EP + +Y++ V GEF V+ +L GL+++ + I N GSVQ +E I
Sbjct: 614 NNESFEPFTSNIYQRRVLSGEFQVVNRHLVKDLAAIGLWNDTMKNLIMYNNGSVQNIESI 673
Query: 1924 PEDMRRVFVTALDIHWLDHLLAQANIQMWLTDSASKTINM 1963
P ++R+++ T ++ + A+ ++ S S + M
Sbjct: 674 PFEIRQLYKTVWEMSMRTMIRMAADRGAFIDQSQSFNVYM 713
>gb|AAA34569.1| (M58012) ribonucleotide reductase DNA damage-inducible regulatory
subunit [Saccharomyces cerevisiae]
Length = 756
Score = 128 bits (318), Expect = 8e-28
Identities = 72/248 (29%), Positives = 129/248 (51%), Gaps = 1/248 (0%)
Query: 1691 CNLASINLAKFVKYDENGKPY-FDWDEYAYVIQKVAKYLDNSIDVNKFPLPEIDYNTKLT 1749
CNLASI L FV+ E+GK ++++ + + + L+ ID N +P+PE +
Sbjct: 441 CNLASIALPAFVEVSEDGKTASYNFERLHEIAKVITHNLNRVIDRNYYPVPEARNSNMKH 500
Query: 1750 RRIGVGMMGLADALFKLGIPYNSEEGFKFMRKVTEYLTFYAYKYSIEAAKKRGTFPLYEK 1809
R I +G+ GLAD L +P+ SEE +++ E + + S E A+K G + +E
Sbjct: 501 RPIALGVQGLADTYMMLRLPFESEEAQTLNKQIFETIYHATLEASCELAQKEGKYSTFEG 560
Query: 1810 TGYPKGELPVEGFYHPEIWNLPWDKLVEEIKKYGVRNAMVTTCPPTGSVSMIADTSSGIE 1869
+ KG L + + W+ L ++I K+G+RN++ PT S S I + E
Sbjct: 561 SPASKGILQFDMWNAKPFGMWDWETLRKDIVKHGLRNSLTMAPMPTASTSQILGYNECFE 620
Query: 1870 PIFALVYKKSVTVGEFYYVDPVFEAELKRRGLYSEELLKKISDNYGSVQGLEEIPEDMRR 1929
P+ + +Y + V GEF V+P +L G++ + + + + GS+QGL +P++++
Sbjct: 621 PVTSNMYSRRVLSGEFQVVNPYLLRDLVDLGIWDDSMKQYLITQNGSIQGLPNVPQELKE 680
Query: 1930 VFVTALDI 1937
++ T +I
Sbjct: 681 LYKTVWEI 688
>pir||WMBY3L ribonucleoside-diphosphate reductase (EC 1.17.4.1) 3 large chain -
yeast (Saccharomyces cerevisiae)
>gi|557803|emb|CAA86157.1| (Z38060) rir3, len: 885, CAI:
0.29, conflict with RIR3_YEAST P21672
RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE [Saccharomyces
cerevisiae]
Length = 885
Score = 128 bits (318), Expect = 8e-28
Identities = 72/248 (29%), Positives = 129/248 (51%), Gaps = 1/248 (0%)
Query: 1691 CNLASINLAKFVKYDENGKPY-FDWDEYAYVIQKVAKYLDNSIDVNKFPLPEIDYNTKLT 1749
CNLASI L FV+ E+GK ++++ + + + L+ ID N +P+PE +
Sbjct: 459 CNLASIALPAFVEVSEDGKTASYNFERLHEIAKVITHNLNRVIDRNYYPVPEARNSNMKH 518
Query: 1750 RRIGVGMMGLADALFKLGIPYNSEEGFKFMRKVTEYLTFYAYKYSIEAAKKRGTFPLYEK 1809
R I +G+ GLAD L +P+ SEE +++ E + + S E A+K G + +E
Sbjct: 519 RPIALGVQGLADTYMMLRLPFESEEAQTLNKQIFETIYHATLEASCELAQKEGKYSTFEG 578
Query: 1810 TGYPKGELPVEGFYHPEIWNLPWDKLVEEIKKYGVRNAMVTTCPPTGSVSMIADTSSGIE 1869
+ KG L + + W+ L ++I K+G+RN++ PT S S I + E
Sbjct: 579 SPASKGILQFDMWNAKPFGMWDWETLRKDIVKHGLRNSLTMAPMPTASTSQILGYNECFE 638
Query: 1870 PIFALVYKKSVTVGEFYYVDPVFEAELKRRGLYSEELLKKISDNYGSVQGLEEIPEDMRR 1929
P+ + +Y + V GEF V+P +L G++ + + + + GS+QGL +P++++
Sbjct: 639 PVTSNMYSRRVLSGEFQVVNPYLLRDLVDLGIWDDSMKQYLITQNGSIQGLPNVPQELKE 698
Query: 1930 VFVTALDI 1937
++ T +I
Sbjct: 699 LYKTVWEI 706
>gi|6322123 Ribonucleotide reductase (ribonucleoside-diphosphate reductase) large
subunit; Rnr3p [Saccharomyces cerevisiae]
>gi|730516|sp|P21672|RIR3_YEAST
RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE CHAIN 2
(RIBONUCLEOTIDE REDUCTASE) (RIBONUCLEOTIDE REDUCTASE DNA
DAMAGE-INDUCIBLE REGULATORY SUBUNIT)
Length = 869
Score = 128 bits (318), Expect = 8e-28
Identities = 72/248 (29%), Positives = 129/248 (51%), Gaps = 1/248 (0%)
Query: 1691 CNLASINLAKFVKYDENGKPY-FDWDEYAYVIQKVAKYLDNSIDVNKFPLPEIDYNTKLT 1749
CNLASI L FV+ E+GK ++++ + + + L+ ID N +P+PE +
Sbjct: 443 CNLASIALPAFVEVSEDGKTASYNFERLHEIAKVITHNLNRVIDRNYYPVPEARNSNMKH 502
Query: 1750 RRIGVGMMGLADALFKLGIPYNSEEGFKFMRKVTEYLTFYAYKYSIEAAKKRGTFPLYEK 1809
R I +G+ GLAD L +P+ SEE +++ E + + S E A+K G + +E
Sbjct: 503 RPIALGVQGLADTYMMLRLPFESEEAQTLNKQIFETIYHATLEASCELAQKEGKYSTFEG 562
Query: 1810 TGYPKGELPVEGFYHPEIWNLPWDKLVEEIKKYGVRNAMVTTCPPTGSVSMIADTSSGIE 1869
+ KG L + + W+ L ++I K+G+RN++ PT S S I + E
Sbjct: 563 SPASKGILQFDMWNAKPFGMWDWETLRKDIVKHGLRNSLTMAPMPTASTSQILGYNECFE 622
Query: 1870 PIFALVYKKSVTVGEFYYVDPVFEAELKRRGLYSEELLKKISDNYGSVQGLEEIPEDMRR 1929
P+ + +Y + V GEF V+P +L G++ + + + + GS+QGL +P++++
Sbjct: 623 PVTSNMYSRRVLSGEFQVVNPYLLRDLVDLGIWDDSMKQYLITQNGSIQGLPNVPQELKE 682
Query: 1930 VFVTALDI 1937
++ T +I
Sbjct: 683 LYKTVWEI 690
>emb|CAA71815.1| (Y10861) ribonucleotide reductase [Nicotiana tabacum]
Length = 808
Score = 127 bits (317), Expect = 1e-27
Identities = 85/270 (31%), Positives = 129/270 (47%), Gaps = 31/270 (11%)
Query: 1691 CNLASINLAKFVKYDENGKP-----------------YFDWDEYAYVIQKVAKYLDNSID 1733
CNLASI L ++V+ E G P YFD+D+ A V V L+ ID
Sbjct: 444 CNLASIALPRYVR--EKGVPSESQPSKLVGSRGSKNRYFDFDKLAEVTALVTTNLNKIID 501
Query: 1734 VNKFPLPEIDYNTKLTRRIGVGMMGLADALFKLGIPYNSEEGFKFMRKVTEYLTFYAYKY 1793
VN +P+ + R IG+G+ GLAD LG+ ++S E + + + E + ++A K
Sbjct: 502 VNYYPVETAKRSNLRHRPIGIGVQGLADTFMLLGMAFDSREAQQLNKDIFETIYYHALKA 561
Query: 1794 SIEAAKKRGTFPLYEKTGYPKGELPVEGFYHPEIWNL------PWDKLVEEIKKYGVRNA 1847
S E A K G + Y G +G P++W + W L E I K GVRN+
Sbjct: 562 SSELAAKEGPYETY------AGSPVSKGIIQPDMWGVTPSDKWDWVALREMITKNGVRNS 615
Query: 1848 MVTTCPPTGSVSMIADTSSGIEPIFALVYKKSVTVGEFYYVDPVFEAELKRRGLYSEELL 1907
++ PT S S I + EP + +Y + V GEF V+ +L GL+S L
Sbjct: 616 LLVAPMPTASTSQILGNNECFEPYTSNIYSRRVLSGEFVVVNKHLLYDLTEMGLWSPALK 675
Query: 1908 KKISDNYGSVQGLEEIPEDMRRVFVTALDI 1937
+I GSVQ + EIP++++ ++ +I
Sbjct: 676 NRIIYEDGSVQKIPEIPDELKEIYKNVWEI 705
>pir||B82959 hypothetical protein PA5497 [imported] - Pseudomonas aeruginosa
(strain PAO1) >gi|9951832|gb|AAG08882.1|AE004962_6
(AE004962) hypothetical protein [Pseudomonas aeruginosa]
Length = 734
Score = 126 bits (314), Expect = 2e-27
Identities = 105/362 (29%), Positives = 162/362 (44%), Gaps = 40/362 (11%)
Query: 1680 CGEEPLYEYESCNLASINLAKFVKYDENGKPYFDWDEYAYVIQKVAKYLDNSIDVNKFPL 1739
CGE+PL Y SC L S+NL FV+ + FDWD + V++ + LDN +++N PL
Sbjct: 342 CGEQPLPPYGSCLLGSVNLTCFVEQPFGDEARFDWDRFREVVRVFTRMLDNVVEINGLPL 401
Query: 1740 PEIDYNTKLTRRIGVGMMGLADALFKLGIPYNSEEGFKFMRKVTEYLTFYAYKYSIEAAK 1799
+ RR G+G +GL L L + Y S E F +V + ++ ++E A+
Sbjct: 402 EQQRQEILGKRRHGMGFLGLGSTLTLLKLRYGSPEACVFTEEVAREMALVGWEVALELAR 461
Query: 1800 KRGTFPL----YEKT-------------GYPKGELPVEGFYHPEIWNLPW------DKLV 1836
++G P+ YE T GY G+ H + +L+
Sbjct: 462 EKGPAPILAQDYEVTAEMLRKRPEMAADGYKAGDRIRGSVLHAKYSRYMQRVAEHAPELI 521
Query: 1837 EEIKKYGVRNAMVTTCPPTG--SVSMIADTSSGIEPIFALVYKKSVTVGEFYYVDPVFEA 1894
E + + G R ++ PTG S+S+ + S+GIEP FA Y +++ + E E
Sbjct: 522 EALAETGARFTHHSSIAPTGTISLSLANNASNGIEPSFAHHYSRNL-IREGRKTKEKVE- 579
Query: 1895 ELKRRGLYSEELLKKISDNYGSVQGLEEIPEDMRRV---FVTALDIHWLDHLLAQANIQM 1951
+YS ELL + Q L + + RR+ F+TA + H+ QA Q
Sbjct: 580 ------VYSYELL--AYRTLVNAQALPDSDDPARRLPDYFITADSVTPAQHMDIQAAAQK 631
Query: 1952 WLTDSASKTINMINEATVEDVKAAYLIAHFLGCKGVTVYRDGSLSVQVYSVEGE--KKRR 2009
W+ S SKT N+ + ED K Y A G KG T +R + Q V+ +K R
Sbjct: 632 WVDSSISKTANVPTDYPFEDFKDIYRYAWHQGLKGCTTFRFNPEAFQGVLVKESDLEKTR 691
Query: 2010 YK 2011
Y+
Sbjct: 692 YR 693
>emb|CAA71816.1| (Y10862) ribonucleotide reductase [Nicotiana tabacum]
Length = 808
Score = 123 bits (307), Expect = 1e-26
Identities = 84/268 (31%), Positives = 129/268 (47%), Gaps = 27/268 (10%)
Query: 1691 CNLASINLAKFVKYDE---------------NGKPYFDWDEYAYVIQKVAKYLDNSIDVN 1735
CNLASI L ++V+ E + YFD+ + A V V L+ IDVN
Sbjct: 444 CNLASIALPRYVREKEVPDESQPSKLVGSRGSKNRYFDFAKLAEVTALVTTNLNKIIDVN 503
Query: 1736 KFPLPEIDYNTKLTRRIGVGMMGLADALFKLGIPYNSEEGFKFMRKVTEYLTFYAYKYSI 1795
+P+ + R IG+G+ GLAD LG+ ++S E + + + E + ++A K S
Sbjct: 504 YYPVETAKRSNLRHRPIGLGVQGLADTFILLGMSFDSPEAQQLNKDIFETIYYHALKASS 563
Query: 1796 EAAKKRGTFPLYEKTGYPKGELPVEGFYHPEIWNLP------WDKLVEEIKKYGVRNAMV 1849
E A K G + Y + KG L P++W + W L I K GVRN+++
Sbjct: 564 ELAAKEGPYETYAGSPVSKGIL------QPDMWGVTPSDRWDWGVLRGMIAKNGVRNSLL 617
Query: 1850 TTCPPTGSVSMIADTSSGIEPIFALVYKKSVTVGEFYYVDPVFEAELKRRGLYSEELLKK 1909
PT S S I + EP + +Y + V GEF V+ +L GL+S L +
Sbjct: 618 VAPMPTASTSQILGNNECFEPYTSNIYSRRVLSGEFVVVNKHLLHDLTEMGLWSPTLKNR 677
Query: 1910 ISDNYGSVQGLEEIPEDMRRVFVTALDI 1937
I + GSVQ + EIP+D++ ++ T +I
Sbjct: 678 IIYDDGSVQKIPEIPQDLKVIYKTVWEI 705
>dbj|BAA78761.1| (AB023482) ESTs C27722(C52692),AU058088(S0509) correspond to a region
of the predicted gene.; Similar to Arabidopsis thaliana
ribonucleoside-diphosphate reductase large subunit mRNA,
complete cds.(AF092841) [Oryza sativa]
Length = 832
Score = 123 bits (306), Expect = 2e-26
Identities = 79/253 (31%), Positives = 122/253 (47%), Gaps = 26/253 (10%)
Query: 1691 CNLASINLAKFVKYDENGKPYFDWDEYAYVIQKVAKYLDNSIDVNKFPLPEIDYNTKLTR 1750
CNLASI L +FV+ V V L+ ID+N +P+ + R
Sbjct: 491 CNLASIALPRFVREK--------------VTSTVTYNLNKIIDINYYPVETAKRSNMRHR 536
Query: 1751 RIGVGMMGLADALFKLGIPYNSEEGFKFMRKVTEYLTFYAYKYSIEAAKKRGTFPLYEKT 1810
IG+G+ GLAD LG+P++S E + + + E + F++ K S E A K G + YE +
Sbjct: 537 PIGIGVQGLADTFILLGMPFDSPEAQQLNKDIFETIYFHSLKASAELAGKEGPYETYEGS 596
Query: 1811 GYPKGELPVEGFYHPEIWNLP------WDKLVEEIKKYGVRNAMVTTCPPTGSVSMIADT 1864
KG L P++WN+ W L I K G+RN+++ PT S S I
Sbjct: 597 PVSKGIL------QPDMWNVVPSDRWNWPSLRSTISKVGLRNSLLVAPMPTASTSQILGN 650
Query: 1865 SSGIEPIFALVYKKSVTVGEFYYVDPVFEAELKRRGLYSEELLKKISDNYGSVQGLEEIP 1924
+ EP + +Y + V GEF V+ +L G+++ L KI GSVQ + IP
Sbjct: 651 NECFEPYTSNIYSRRVLSGEFVVVNKHLLHDLTEMGVWTPALKNKIIYEDGSVQKMTVIP 710
Query: 1925 EDMRRVFVTALDI 1937
+D++ ++ T +I
Sbjct: 711 DDLKAIYKTVWEI 723
>gi|6320914 ribonucleotide reductase; Rnr1p [Saccharomyces cerevisiae]
>gi|730514|sp|P21524|RIR1_YEAST
RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE CHAIN 1
(RIBONUCLEOTIDE REDUCTASE) >gi|1071828|pir||S50573
ribonucleotide reductase (EC 1.17.4.-) large chain 1 -
yeast (Saccharomyces cerevisiae)
>gi|603306|gb|AAB64606.1| (U18813) Rnr1p: Ribonucleotide
reductase [Saccharomyces cerevisiae]
Length = 888
Score = 122 bits (303), Expect = 4e-26
Identities = 71/248 (28%), Positives = 130/248 (51%), Gaps = 1/248 (0%)
Query: 1691 CNLASINLAKFVKYDENGKPY-FDWDEYAYVIQKVAKYLDNSIDVNKFPLPEIDYNTKLT 1749
CNLAS+ L F++ E+GK +++ + + + V + L+ ID N +P+ E +
Sbjct: 443 CNLASVALPAFIETSEDGKTSTYNFKKLHEIAKVVTRNLNRVIDRNYYPVEEARKSNMRH 502
Query: 1750 RRIGVGMMGLADALFKLGIPYNSEEGFKFMRKVTEYLTFYAYKYSIEAAKKRGTFPLYEK 1809
R I +G+ GLAD L +P++SEE ++ E + + + S E A+K G + ++
Sbjct: 503 RPIALGVQGLADTFMLLRLPFDSEEARLLNIQIFETIYHASMEASCELAQKDGPYETFQG 562
Query: 1810 TGYPKGELPVEGFYHPEIWNLPWDKLVEEIKKYGVRNAMVTTCPPTGSVSMIADTSSGIE 1869
+ +G L + + WD L ++I K+GVRN++ PT S S I + E
Sbjct: 563 SPASQGILQFDMWDQKPYGMWDWDTLRKDIMKHGVRNSLTMAPMPTASTSQILGYNECFE 622
Query: 1870 PIFALVYKKSVTVGEFYYVDPVFEAELKRRGLYSEELLKKISDNYGSVQGLEEIPEDMRR 1929
P+ + +Y + V GEF V+P +L G++ E + + + GS+QGL +P++++
Sbjct: 623 PVTSNMYSRRVLSGEFQVVNPYLLRDLVDLGIWDEGMKQYLITQNGSIQGLPNVPQELKD 682
Query: 1930 VFVTALDI 1937
++ T +I
Sbjct: 683 LYKTVWEI 690
>sp|P50647|RIR1_PLAFG RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE CHAIN (RIBONUCLEOTIDE
REDUCTASE R1 SUBUNIT) >gi|539408|pir||B48687
ribonucleoside-diphosphate reductase (EC 1.17.4.1) large
chain - malaria parasite (Plasmodium falciparum)
>gi|349792|gb|AAA29755.1| (AF205580) ribonucleotide
reductase large subunit [Plasmodium falciparum]
Length = 804
Score = 120 bits (299), Expect = 1e-25
Identities = 75/258 (29%), Positives = 132/258 (51%), Gaps = 17/258 (6%)
Query: 1687 EYESCNLASINLAKFVKYDENGKPYFDWDEYAYVIQKVAKYLDNSIDVNKFPLPEIDYNT 1746
E CNLASI L KFV + K F++ + + + + + LD I+ N +P+ E +
Sbjct: 438 EVAVCNLASIALCKFVDLE---KKEFNFKKLYEITKIITRNLDKIIERNYYPVKEAKTSN 494
Query: 1747 KLTRRIGVGMMGLADALFKLGIPYNSEEGFKFMRKVTEYLTFYAYKYSIEAAKKRGTFPL 1806
R IG+G+ GLAD L Y S+ + +++ E + + A + S++ + G +
Sbjct: 495 TRHRPIGIGVQGLADTFMLLRYLYESDAAKELNKRIYETMYYAALEMSVDWLQS-GPYES 553
Query: 1807 YEKTGYPKGELPVEGFYHPEIWNLP-------WDKLVEEIKKYGVRNAMVTTCPPTGSVS 1859
Y+ G +G ++WN WD+L +I K G+RN ++ PT S S
Sbjct: 554 YQ------GSPGSQGILQFDMWNAKVDNKYWDWDELKLKIAKTGLRNLLLLAPMPTASTS 607
Query: 1860 MIADTSSGIEPIFALVYKKSVTVGEFYYVDPVFEAELKRRGLYSEELLKKISDNYGSVQG 1919
I + EP + +Y + V GEF+ V+P +L RGL+ E++ +++ + GS+Q
Sbjct: 608 QILGNNESFEPYTSNIYYRRVLSGEFFVVNPHLLKDLFDRGLWDEDMKQQLIAHNGSIQY 667
Query: 1920 LEEIPEDMRRVFVTALDI 1937
+ EIP+D++ ++ T +I
Sbjct: 668 ISEIPDDLKELYKTVWEI 685
>gb|AAD37499.1|AF111267_1 (AF111267) regulatory protein SCTI [Streptomyces cattleya]
Length = 599
Score = 115 bits (284), Expect = 7e-24
Identities = 100/368 (27%), Positives = 162/368 (43%), Gaps = 30/368 (8%)
Query: 1690 SCNLASINLAKFVKYDE--------NGKPYFDWDEYAYVIQKVAKYLDNSIDVNKFPLPE 1741
SCNLAS+NL KF++ D G D + +A V++ V +D SI FP +
Sbjct: 7 SCNLASLNLMKFLRDDTASDGASGAGGNMSLDAERFAKVVELVITAMDISICFADFPTEK 66
Query: 1742 IDYNTKLTRRIGVGMMGLADALFKLGIPYNSEEGFKFMRKVTEYLTFYAYKYSIEAAKKR 1801
I T+ R++G+G L L G Y+S+ G +T +T +Y+ S E A
Sbjct: 67 IGETTRAFRQLGIGYANLGALLMATGHAYDSDGGRALAGAITSLMTGTSYRRSAELAAVV 126
Query: 1802 GTFPLYEKTGYPKGELPVEGF-----------YHPEIWNLP---WDKLVEEIKKYGVRNA 1847
G + Y + + + +W W ++ ++ RNA
Sbjct: 127 GPYEGYARNADAHKRVMRQHADANTAAQRMDDLDTPVWAAATEAWQDVLRLGEQNRFRNA 186
Query: 1848 MVTTCPPTGSVSMIADT-SSGIEPIFALV-YKKSVTVGEFYYVDPVFEAELKRRGLYSEE 1905
+ PTG++ ++ D ++G+EP ALV +KK V G V+ LKR G E+
Sbjct: 187 QASVLAPTGTIGLMMDCDTTGVEPDLALVKFKKLVGGGSMQIVNNTVPKALKRLGYQPEQ 246
Query: 1906 LLKKISD--NYGSVQGLEEIPEDMRRVFVTALD---IHWLDHLLAQANIQMWLTDSASKT 1960
+ ++ +G+V + + VF A+ I + H+ A Q +L+ + SKT
Sbjct: 247 VEAVVAHIAEHGNVIDAPGLKPEHYEVFDCAMGERAISPMGHVRMMAAAQPFLSGAISKT 306
Query: 1961 INMINEATVEDVKAAYLIAHFLGCKGVTVYRDGSLSVQVYSVEGEKKRRYKPKPSEYAKK 2020
+NM ATVE+++ Y LG K + +YRD Q S + +K+ P+E K
Sbjct: 307 VNMPESATVEEIEEIYYEGWKLGLKALAIYRDNCKVGQPLSAK-KKEEAKTEAPAEVEKV 365
Query: 2021 VLLEIVEK 2028
V V K
Sbjct: 366 VEYRPVRK 373
>pir||E64477 replication factor C homolog - Methanococcus jannaschii
>gi|1592072|gb|AAB99433.1| (U67583) activator 1
(replication factor C), 35 KD subunit [Methanococcus
jannaschii]
Length = 1847
Score = 102 bits (252), Expect = 4e-20
Identities = 112/441 (25%), Positives = 188/441 (42%), Gaps = 95/441 (21%)
Query: 1377 YVWKVGMKEVARVRTKEGYEITATLDHKLMTPEG-----WKEIKDLKPGDKILLPRFEVE 1431
YV+K + +++TK G E+ T H L+ W++ ++LK GDK+ PR+ +
Sbjct: 108 YVYKDKTNTLIKIKTKMGRELKVTTYHPLLINHKNGEIKWEKAENLKVGDKLATPRYIL- 166
Query: 1432 EDFGSESIGEDLAFVLGWFIGDGYLNVKDKRAWFYFNAEKEEEIAWKIREILAKRFEIKA 1491
F E+LA LG+FIGDG+ + + + F EK + ++ E L K +IK
Sbjct: 167 --FNESDYNEELAEWLGYFIGDGHADKESNKITFTNGDEKLRKRFAELTEKLFKDAKIKE 224
Query: 1492 EPHR------YGNQ-------IKLGVRGKAYEWLESIVKTNEKRIPEIVYRLKPNEIASF 1538
H+ Y N KLG+RGK K ++ RIP+ + ++ + + +F
Sbjct: 225 RIHKDRTPDIYVNSKEAVEFIDKLGLRGK---------KADKVRIPKEI--MRSDALRAF 273
Query: 1539 LRGLFSADGYVDNDMAIRLTSKSRELLREVQDLLLLFGILSKIYERPYKREFKYTTKDGE 1598
LR F DG ++ +I L++ S+E+ ++ LL FGI++K+ E+ K K
Sbjct: 274 LRAYFDCDGGIEKH-SIVLSTASKEMAEDLVYALLRFGIIAKLREKVNKNNNKV------ 326
Query: 1599 ERTYTTEGYYELVIANYSR-KIFAERIGLEGYKMEKLSLEKIKVDEP---IVTVESVEI- 1653
YY +VI+N S + F + IG + K LE IK + P ++T++ +I
Sbjct: 327 --------YYHIVISNSSNLRTFLDNIGFSQERKLKKLLEIIKDENPNLDVITIDKEKIR 378
Query: 1654 -----LGKKLVYDFTVPEHHMYISNGFMSHNCGEEPLYEYESCNLASINLAKFVKY---- 1704
L KL D E+ + Y C + L K + Y
Sbjct: 379 YIRDRLKVKLTRDI-------------------EKDNWSYNKCRKITQELLKEIYYRLEE 419
Query: 1705 --------DENGKPYFDWDEYAYVIQKVAKYLDNSID-----VNKFPLPEIDYNTKLTRR 1751
+EN DWDE A +++A+ D + P + K+
Sbjct: 420 LKEIEKALEEN--ILIDWDEVAERRKEIAEKTGIRSDRILEYIRGKRKPSLKNYIKIANT 477
Query: 1752 IGVGMMGLADALFKLGIPYNS 1772
+G + + DA+ Y+S
Sbjct: 478 LGKNIEKIIDAMRIFAKKYSS 498
Score = 95.2 bits (233), Expect = 7e-18
Identities = 105/409 (25%), Positives = 180/409 (43%), Gaps = 68/409 (16%)
Query: 723 CFTGDTRILTEKGLIPIEEIVHETGKKPKVVTHAGLKDIIETYDNGEMEVF--------- 773
C TGDT+++ + I E++ E VT ++ ++G++ F
Sbjct: 54 CLTGDTKVIVNGEIREIGEVIEEISNGKFGVTLTNNLKVLGIDEDGKIREFDVQYVYKDK 113
Query: 774 -----RVTTEDGYELKVTGDHKFLVFDENGNPTLKPLKELKVGDYVYILAPEWKGGEYVE 828
++ T+ G ELKVT H L+ +NG + + LKVGD
Sbjct: 114 TNTLIKIKTKMGRELKVTTYHPLLINHKNGEIKWEKAENLKVGD---------------- 157
Query: 829 LDTNIELKGKGYNVNLPSKLDEKLAYLLGIIYADGHIRHYFENGKRKNSKIEIYLHQDET 888
+L Y + S +E+LA LG DGH ++++KI T
Sbjct: 158 -----KLATPRYILFNESDYNEELAEWLGYFIGDGH-------ADKESNKITF------T 199
Query: 889 EIKEKVKRYFKEIFGIEPKEF-LKEEQHK---VILVIPSTKIVKFLEINGLLKDKSENIR 944
EK+++ F E+ K+ +KE HK + + S + V+F++ GL K++ +R
Sbjct: 200 NGDEKLRKRFAELTEKLFKDAKIKERIHKDRTPDIYVNSKEAVEFIDKLGLRGKKADKVR 259
Query: 945 VPEAIFRSRPSVIAAFLAGFFDGDGSIDQNYRIAFKSISREFIKEAQLLFLALGIVTSIQ 1004
+P+ I RS + AFL +FD DG I++ + I + S+E ++ L GI+ ++
Sbjct: 260 IPKEIMRS--DALRAFLRAYFDCDGGIEK-HSIVLSTASKEMAEDLVYALLRFGIIAKLR 316
Query: 1005 EYNPPNPNNKTVYTLRVQTRDMKIKAF--NV-LKESVKLSKIMKEAISKLEENGKNKKFS 1061
E N NN VY V + ++ F N+ + KL K++ E I +EN +
Sbjct: 317 E--KVNKNNNKVYYHIVISNSSNLRTFLDNIGFSQERKLKKLL-EIIK--DENPNLDVIT 371
Query: 1062 FPFNAIYHIKDPKIRAKIQRDYK--ILSYNS--KVTHRAFINNILKLKE 1106
I +I+D +++ K+ RD + SYN K+T +L+E
Sbjct: 372 IDKEKIRYIRD-RLKVKLTRDIEKDNWSYNKCRKITQELLKEIYYRLEE 419
>gb|AAG27192.1|AF275348_12 (AF275348) ribonucleotide reductase, large subunit [Cercopithecine
herpesvirus 7]
Length = 783
Score = 100 bits (246), Expect = 2e-19
Identities = 66/244 (27%), Positives = 113/244 (46%), Gaps = 10/244 (4%)
Query: 1691 CNLASINLAKFV-KYDENGKPYFDWDEYAYVIQKVAKYLDNSIDVNKFPLPEIDYNTKLT 1749
CNLA+IN+A + DE+G P F + + + ++ +L+ + FP +
Sbjct: 448 CNLANINIANCILNGDEDGPPEFSFADLTFAVRTAVVFLNGVLAAGNFPCKKSCEGVANN 507
Query: 1750 RRIGVGMMGLADALFKLGIPYNSEEGFKFMRKVTEYLTFYAYKYSIEAAKKRGTFPL--Y 1807
R +G+G+ GL A +LG+ + ++TE + + A S+ K+ G P +
Sbjct: 508 RSLGIGIQGLHTAFLRLGLDLTCPRARRLNVEITESMLYEAMFVSMNMCKQCGLQPFHEF 567
Query: 1808 EKTGYPKGELPVEGFYHPEIWNLPWDKLVEEIKKYGVRNAMVTTCPPTGSVSMIADTSSG 1867
E + Y G L +GF NLPW++L ++I +YG+ N+ PT + + + + S G
Sbjct: 568 ENSKYASGWLHFDGFPTCSYLNLPWEELRDDICQYGLYNSQFLAFMPTVASAQVTECSEG 627
Query: 1868 IEPIFALVYKKSVTVGEFYYVDPVFEAELKRRGLYSEELLKKISDNYGSVQGLEEIPEDM 1927
P+F ++ K GE + P E + R LY E D +Q LE+ +
Sbjct: 628 FSPVFTNMFSKVTISGE--TLRPNLELMDELRKLYPHE-----EDRSRIIQQLEKNQWSV 680
Query: 1928 RRVF 1931
R F
Sbjct: 681 LRTF 684
>pir||H72510 probable ribonucleotide reductase APE2062 - Aeropyrum pernix (strain
K1) >gi|5105760|dbj|BAA81072.1| (AP000063) 983aa long
hypothetical ribonucleotide reductase [Aeropyrum pernix]
Length = 983
Score = 99.5 bits (244), Expect = 4e-19
Identities = 70/200 (35%), Positives = 102/200 (51%), Gaps = 38/200 (19%)
Query: 1832 WDKLVEEIKKYGV---RNAMVTTCPPTGSVSMIADTSSGIEPIFALVYKKSVTVGEFYYV 1888
W L E ++ G RN + TT PTG++S++A TSSGIEP FALVYK+ V VG F V
Sbjct: 719 WRLLREYGRRLGAKAPRNTVTTTIAPTGTISILAGTSSGIEPYFALVYKRQVAVGTFLEV 778
Query: 1889 ----------------------DPVFEAELKRRG-------LYSEELLKKISDNYGSVQG 1919
+ V+E + +G + +E+L ++ D +
Sbjct: 779 VSRFREDLLKAAEKHGVGRDVLEIVYEEVRRHKGSLRWSLNVLAEKLDGRVDDGF----- 833
Query: 1920 LEEIPEDMRRVFVTALDIHWLDHLLAQANIQMWLTDSASKTINMINEATVEDVKAAYLIA 1979
LEE+ + R + T++D HL Q Q+++ + SKT+N+ AT +DV+A+YL A
Sbjct: 834 LEELAR-LARKYATSMDFPLWYHLAHQIAAQLYVDQAISKTVNLPRTATPDDVEASYLAA 892
Query: 1980 HFLGCKGVTVYRDGSLSVQV 1999
G KG TVYRD S QV
Sbjct: 893 WLGGLKGFTVYRDESKGRQV 912
Score = 88.5 bits (216), Expect = 7e-16
Identities = 49/129 (37%), Positives = 75/129 (57%), Gaps = 5/129 (3%)
Query: 1680 CGEEPLYEYESCNLASINLAKFVKYDENGKPYFDWDEYAYVIQKVAKYLDNSIDVNKFPL 1739
C E+ LY +E CNL S+++ K+V G+ FD + +A ++ + + +D ID+N+ P
Sbjct: 471 CSEQTLYPFEPCNLGSLSVDKYVA---GGR--FDLERFANDVEFLTEAMDAVIDLNRHPD 525
Query: 1740 PEIDYNTKLTRRIGVGMMGLADALFKLGIPYNSEEGFKFMRKVTEYLTFYAYKYSIEAAK 1799
D K TR+IG+G+MGLADAL LG PY+SEE F + L +++K S E
Sbjct: 526 ERQDTANKFTRKIGLGIMGLADALAGLGYPYDSEEAVAFTTILMAGLEVFSWKRSWEMGA 585
Query: 1800 KRGTFPLYE 1808
+ G P +E
Sbjct: 586 RLGHAPAFE 594
>gi|9628153 ribonucleotide reductase large subunit [African swine fever virus]
>gi|1172937|sp|P42491|RIR1_ASFB7
RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE CHAIN
(RIBONUCLEOTIDE REDUCTASE) >gi|780415|gb|AAA65275.1|
(U18466) ribonucleotide reductase large subunit [African
swine fever virus] >gi|1097434|prf||2113434AU
ribonucleotide reductase:SUBUNIT=large [African swine
fever virus]
Length = 778
Score = 99.5 bits (244), Expect = 4e-19
Identities = 73/281 (25%), Positives = 127/281 (44%), Gaps = 33/281 (11%)
Query: 1680 CGEEPLYEYESCNLASINLAKFVKYDENGKPYFDWDEYAYVIQKVAKYLDNSIDVNKFPL 1739
C E E CNLA++NLA F++ ENG +D+ V + LDN ID +P
Sbjct: 428 CWEGDKAEQGVCNLAAVNLAAFIR--ENG---YDYRGLIEASGNVTENLDNIIDNGYYPT 482
Query: 1740 PEIDYNTKLTRRIGVGMMGLADALFKLGIPYNSEEGFKFMRKVTEYLTFYAYKYSIEAAK 1799
+ R IG+G+ GLAD L + + S E + L + A + SIE AK
Sbjct: 483 EATRRSNMRHRPIGIGVFGLADVFASLKMKFGSPEAIAMDEAIHAALYYGAMRRSIELAK 542
Query: 1800 KRGTFPLYEKTGYPKGELPVEGFYHPEIW------NLPWDKLVEEIKK------------ 1841
++G+ P + G +G P++W + W++ V + +
Sbjct: 543 EKGSHPSF------PGSAASKGLLQPDLWVRCGDLSSSWEERVAQTTQGVLTRKSWWQLR 596
Query: 1842 ----YGVRNAMVTTCPPTGSVSMIADTSSGIEPIFALVYKKSVTVGEFYYVDPVFEAELK 1897
GVRN +T PT + S + EP + +Y + GEF ++ +LK
Sbjct: 597 LAAMQGVRNGYLTALMPTATSSNSTGKNECFEPFTSNLYTRRTLSGEFIVLNKYLIDDLK 656
Query: 1898 RRGLYSEELLKKISDNYGSVQGLEEIPEDMRRVFVTALDIH 1938
L++E + +++ + GS+Q + +IP ++R + T+ +++
Sbjct: 657 EIDLWTEAIQQQLLNAGGSIQHILDIPAEIRDRYKTSREMN 697
>sp|P26685|RIR1_ASFM2 RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE CHAIN (RIBONUCLEOTIDE
REDUCTASE) >gi|66403|pir||WMVZAL
ribonucleoside-diphosphate reductase (EC 1.17.4.1) large
chain - African swine fever virus (strain Malawi LIL20/1)
>gi|554615|gb|AAA42732.1| (M64728) ribonuclease reductase
[African swine fever virus]
Length = 779
Score = 97.5 bits (239), Expect = 1e-18
Identities = 73/281 (25%), Positives = 127/281 (44%), Gaps = 33/281 (11%)
Query: 1680 CGEEPLYEYESCNLASINLAKFVKYDENGKPYFDWDEYAYVIQKVAKYLDNSIDVNKFPL 1739
C E E CNLA++NLA F++ +D+ V + LDN ID +P
Sbjct: 429 CWEGNEAEQGVCNLAAVNLAAFIRESS-----YDYRGLIEAAGNVTENLDNIIDNGYYPT 483
Query: 1740 PEIDYNTKLTRRIGVGMMGLADALFKLGIPYNSEEGFKFMRKVTEYLTFYAYKYSIEAAK 1799
+ R IG+G+ GLAD L + + S E + L + A + SIE AK
Sbjct: 484 EATRRSNMRHRPIGIGVFGLADVFASLKMKFGSPEAIAIDEAIHAALYYGAMRRSIELAK 543
Query: 1800 KRGTFPLYEKTGYPKGELPVEGFYHPEIW-----NLP-WDKLVEEI-------KKY---- 1842
++G+ P + G +G P++W +P W+ V + KK+
Sbjct: 544 EKGSHPSF------PGSAASKGLLQPDLWVRCGDLIPSWENRVAQTTQGVLTPKKWWQLR 597
Query: 1843 -----GVRNAMVTTCPPTGSVSMIADTSSGIEPIFALVYKKSVTVGEFYYVDPVFEAELK 1897
GVRN +T PT + S + EP + +Y + GEF ++ +L+
Sbjct: 598 LAAIQGVRNGYLTALMPTATSSNSTGKNECFEPFTSNLYTRRTLSGEFIILNKYLMDDLE 657
Query: 1898 RRGLYSEELLKKISDNYGSVQGLEEIPEDMRRVFVTALDIH 1938
L+SE++ +++ + GS+Q + +IP ++R + T+ +++
Sbjct: 658 EINLWSEDIQQQLLNAGGSIQHILDIPAEIRERYKTSREMN 698
>pir||D75028 h+-transporting ATP synthase, chain alpha (atpa) PAB2378 - Pyrococcus
abyssi (strain Orsay) >gi|5459180|emb|CAB50666.1|
(AJ248288) H+-transporting ATP synthase, subunit Alpha
(atpA) [Pyrococcus abyssi]
Length = 1017
Score = 93.2 bits (228), Expect = 3e-17
Identities = 98/319 (30%), Positives = 150/319 (46%), Gaps = 42/319 (13%)
Query: 714 IVGTTTGAACFTGDTRILTEK-GLIPIEE---IVHETGKKP-----------KVVTHAGL 758
I G C GDT +LT++ GLI I++ I+ GKK + +T G
Sbjct: 232 IPGPFGSGKCVDGDTLVLTKEFGLIKIKDLYKILDGKGKKTVNGNEEWTELERPITLYGY 291
Query: 759 KD--IIE-----TYDNGEMEVFRVTTEDGYELKVTGDHKFLV--FDENGNPTLKPL-KEL 808
KD I+E Y + + T G ++KVT HK +NG + + K+L
Sbjct: 292 KDGKIVEIKATHVYKGFSAGMIEIRTRTGRKIKVTPIHKLFTGRVTKNGLEIREVMAKDL 351
Query: 809 KVGDYVYILAPEWKGGEYVELDTNIELKGKGYNVNLPSKLDEKLAYLLGIIYADGHIRHY 868
K GD + I+A + GGE V+L+ +E K +G + +P LDEKLA LG + ADG +
Sbjct: 352 KKGDRI-IVAKKIDGGERVKLNIRVEQK-RGKKIRIPDVLDEKLAEFLGYLIADGTL--- 406
Query: 869 FENGKRKNSKIEIYLHQDETEIKEKVKRYFKEIFGIEPKEFLKEEQHKVILVIPSTKIVK 928
K + IY + DE+ ++ + E+F IE K +K K +L I S +V+
Sbjct: 407 ------KPRTVAIY-NNDESLLR-RANELANELFNIEGK-IVKGRTVKALL-IHSKALVE 456
Query: 929 FLEINGLLKD-KSENIRVPEAIFRSRPSVIAAFLAGFFDGDGSIDQNY-RIAFKSISREF 986
F G+ ++ K+ +VP+ + S P V+ AF+ + DG D+N I + S E
Sbjct: 457 FFSKLGVPRNKKARTWKVPKELLISEPEVVKAFIKAYIMCDGYYDENKGEIEIVTASEEA 516
Query: 987 IKEAQLLFLALGIVTSIQE 1005
L LGI I+E
Sbjct: 517 AYGFSYLLAKLGIYAIIRE 535
Score = 73.0 bits (176), Expect = 3e-11
Identities = 102/383 (26%), Positives = 156/383 (40%), Gaps = 79/383 (20%)
Query: 1286 EAKGGPIRATNP-----CVVGETRILTPE-GYIKAEELFKLAKERGKMEAIAVEGIAEGG 1339
+AKGG P CV G+T +LT E G IK ++L+K+ +GK E E
Sbjct: 224 QAKGGTAAIPGPFGSGKCVDGDTLVLTKEFGLIKIKDLYKILDGKGKKTVNGNEEWTELE 283
Query: 1340 EPYAYSLEILLPGDKQVKYETVHGNAVEVADPVSVPAYVWKVGMKEVARVRTKEGYEITA 1399
P I L G K G VE+ +V+K + +RT+ G +I
Sbjct: 284 RP------ITLYGYKD-------GKIVEIK-----ATHVYKGFSAGMIEIRTRTGRKIKV 325
Query: 1400 TLDHKLMTPEGWKE--------IKDLKPGDKILLPR-----------FEVEEDFGS---- 1436
T HKL T K KDLK GD+I++ + VE+ G
Sbjct: 326 TPIHKLFTGRVTKNGLEIREVMAKDLKKGDRIIVAKKIDGGERVKLNIRVEQKRGKKIRI 385
Query: 1437 -ESIGEDLAFVLGWFIGDGYLNVKDKRAWFYFNAEKEEEIAWKIREILAKRFEIKAEPHR 1495
+ + E LA LG+ I DG L K + Y N +E + + E+ + F I+ + +
Sbjct: 386 PDVLDEKLAEFLGYLIADGTL--KPRTVAIYNN---DESLLRRANELANELFNIEGKIVK 440
Query: 1496 YGNQIKLGVRGKAY-EWLESI-VKTNEK----RIPEIVYRLKPNEIASFLRGLFSADGYV 1549
L + KA E+ + V N+K ++P+ + +P + +F++ DGY
Sbjct: 441 GRTVKALLIHSKALVEFFSKLGVPRNKKARTWKVPKELLISEPEVVKAFIKAYIMCDGYY 500
Query: 1550 D-NDMAIRLTSKSRELLREVQDLLLLFGILSKIYERPYKREFKYTTKDGEERTYTTEGYY 1608
D N I + + S E LL GI + I E+ + YY
Sbjct: 501 DENKGEIEIVTASEEAAYGFSYLLAKLGIYAII----------------REKIIGDKVYY 544
Query: 1609 ELVIANYS--RKIFAERIGLEGY 1629
+VI+ S K+ ER+G GY
Sbjct: 545 RVVISGESNLEKLGIERVG-RGY 566
>pir||E82223 ribonucleoside-diphosphate reductase, alpha chain VC1256 [imported] -
Vibrio cholerae (group O1 strain N16961)
>gi|9655739|gb|AAF94415.1| (AE004204)
ribonucleoside-diphosphate reductase, alpha subunit
[Vibrio cholerae]
Length = 761
Score = 92.8 bits (227), Expect = 4e-17
Identities = 69/240 (28%), Positives = 115/240 (47%), Gaps = 21/240 (8%)
Query: 1682 EEPLYEYESCNLASINLAKFVKYDENGKPYFDWDEYAYVIQKVAKYLDNSIDVNKFPLPE 1741
E+ E C L++ NL D D++E + + V + LD +D +PLP
Sbjct: 453 EDESGEIALCTLSAFNLGAIESLD-------DFEELSDL---VVRALDALLDYQDYPLPA 502
Query: 1742 IDYNTKLTRRIGVGMMGLADALFKLGIPYNSEEGFKFMRKVTEYLTFYAYKYSIEAAKKR 1801
++ R +GVG++ A L K G+ Y+ + E + ++ + S++ AK++
Sbjct: 503 ARRSSMNRRTLGVGVINYAYYLAKNGVKYSDGSANGLTHRTFEAMQYHLLRASMKLAKEQ 562
Query: 1802 GTFPLYEKTGYPKGELPVEGFYH------PEIWNLPWDKLVEEIKKYGVRNAMVTTCPPT 1855
G PL+ +T Y KG +P++ + E + WDKL EI ++G+RN+ +T P+
Sbjct: 563 GRCPLFHETNYAKGLMPIDTYKKDIDLVCAEPLHYDWDKLRHEIMEHGLRNSTLTALMPS 622
Query: 1856 GSVSMIADTSSGIEPIFALVYKKSVTVGEFYYVDPVFEAELKRRGLYSEELLKKISDNYG 1915
+ S I++ ++GIEP V K+ G V P F LK + ELL I N G
Sbjct: 623 ETSSQISNATNGIEPPRGYVSVKASKDGILKQVVPEF-TRLKE----NYELLWNIGSNDG 677
>dbj|BAB04220.1| (AP001508) ribonucleoside-diphosphate reductase alpha subunit
[Bacillus halodurans]
Length = 726
Score = 92.4 bits (226), Expect = 5e-17
Identities = 52/190 (27%), Positives = 98/190 (51%), Gaps = 14/190 (7%)
Query: 1687 EYESCNLASINLAKFVKYDENGKPYFDWDEYAYVIQKVAKYLDNSIDVNKFPLPEIDYNT 1746
+Y CNL+S++LA+ V+ D + +I + LDN IDVN+ + + +
Sbjct: 453 DYVVCNLSSLSLARVVEDDVLER----------LIPIQVRMLDNVIDVNRIEVKQAEQTN 502
Query: 1747 KLTRRIGVGMMGLADALFKLGIPYNSEEGFKFMRKVTEYLTFYAYKYSIEAAKKRGTFPL 1806
+ R IG+G G L K GI + SEE ++ ++ E + + + S++ A+++G +P+
Sbjct: 503 QKYRAIGLGTYGWHHLLAKKGIAWESEEAIRYADELYETINYLTIQASMKLAEEKGAYPM 562
Query: 1807 YEKTGYPKGELPVEGFYHPEIWNLPWDKLVEEIKKYGVRNAMVTTCPPTGSVSMIADTSS 1866
+ + + GE F + W +L E++K+ G+RN + P + ++I T++
Sbjct: 563 FGGSDWETGEY----FERRQYTTDKWTELAEQVKEKGLRNGYLLAVAPNATTALIGGTTA 618
Query: 1867 GIEPIFALVY 1876
I+PIF Y
Sbjct: 619 SIDPIFQKTY 628
>pir||C81418 ribonucleoside-diphosphate reductase (EC 1.17.4.1) alpha chain Cj0024
[imported] - Campylobacter jejuni (strain NCTC 11168)
>gi|6967529|emb|CAB72517.1| (AL139074)
ribonucleoside-diphosphate reductase alpha chain
[Campylobacter jejuni]
Length = 789
Score = 91.7 bits (224), Expect = 8e-17
Identities = 66/242 (27%), Positives = 114/242 (46%), Gaps = 25/242 (10%)
Query: 1691 CNLASINLAKFVKYDENGKPYFDWDEYAYVIQKVAKYLDNSIDVNKFPLPEIDYNTKLTR 1750
CNLASINL+K + ++ V+ + LDN ID+N +P ++ +R
Sbjct: 496 CNLASINLSKV----------YTKEDIERVVPTAIRMLDNVIDLNFYPHRKVKDTNLKSR 545
Query: 1751 RIGVGMMGLADALFKLGIPYNSEEGFKFMRKVTEYLTFYAYKYSIEAAKKRGTFPLYEKT 1810
IG+G+MG A L + I + S+E + ++ E ++F A S A ++G++ +E +
Sbjct: 546 AIGLGVMGEAQMLAEAKIHWGSDEHLNKIDEIMEQISFEAINASSNLALEKGSYEDFEGS 605
Query: 1811 GYPKGELPV-------------EGFYHPEIWNLPWDKLVEEIKKYGVRNAMVTTCPPTGS 1857
+ KG P+ EG + W KL E++KK G+RN + PT S
Sbjct: 606 NWSKGIFPIDVASPKAKALTLREGLFDQS--ECDWVKLREKVKKDGMRNGYLMAIAPTSS 663
Query: 1858 VSMIADTSSGIEPIFALVYKKSVTVGEFYYVDPVFEAELKRRGLYSEELLKKISDNYGSV 1917
+S++ T+ IEP++ + + G V P + + + EL +KI +V
Sbjct: 664 ISILVGTTQTIEPVYKRKWFEQNLSGMIPVVVPNLSLDTWQYYTPAYELDQKILVKAAAV 723
Query: 1918 QG 1919
+G
Sbjct: 724 RG 725
>sp|P55982|RIR1_HELPY RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE ALPHA CHAIN (RIBONUCLEOTIDE
REDUCTASE) >gi|7433358|pir||H64604
ribonucleoside-diphosphate reductase (EC 1.17.4.1) 1
alpha chain [similarity] - Helicobacter pylori (strain
26695) >gi|2313806|gb|AAD14884.1| (AE000581)
ribonucleoside-diphosphate reductase 1 alpha subunit
(nrdA) [Helicobacter pylori 26695]
Length = 788
Score = 90.9 bits (222), Expect = 1e-16
Identities = 85/322 (26%), Positives = 141/322 (43%), Gaps = 51/322 (15%)
Query: 1691 CNLASINLAKFVKYDENGKPYFDWDEYAYVIQKVAKYLDNSIDVNKFPLPEIDYNTKLTR 1750
CNLASINL+K + +E+ K V+ + + LDN ID+N +P ++ R
Sbjct: 497 CNLASINLSK-INTEEDIKR---------VVPIMVRLLDNVIDLNFYPNRKVKATNLQNR 546
Query: 1751 RIGVGMMGLADALFKLGIPYNSEEGFKFMRKVTEYLTFYAYKYSIEAAKKRGTFPLYEKT 1810
IG+G+MG A L + I + S+E + + + E ++++A S AK++G + +E +
Sbjct: 547 AIGLGVMGEAQMLAEHQIAWGSKEHLEKIDALMEQISYHAIDTSANLAKEKGVYKDFENS 606
Query: 1811 GYPKGELPVEGFYHPEI---------WNLPWDKLVEEIKKYGVRNAMVTTCPPTGSVSMI 1861
+ KG P++ + + W L E++K G+RN + PT S+S++
Sbjct: 607 EWSKGIFPIDKANNEALKLTEKGLFNHACDWQGLREKVKANGMRNGYLMAIAPTSSISIL 666
Query: 1862 ADTSSGIEPIFALVYKKSVTVGEFYYVDPVFEAELKRRGLYSEELLKKISDNYGSVQGLE 1921
T+ IEPI YKK FE L L+ + N
Sbjct: 667 VGTTQTIEPI----YKKK-----------WFEENL-------SGLIPVVVPN-------- 696
Query: 1922 EIPEDMRRVFVTALDIHWLDHLLAQANIQMWLTDSASKTINM-INEATVEDVKAAYLIAH 1980
+ + + +A DI D + A A Q W+ S + + I A+ + + Y +A
Sbjct: 697 -LNVETWNFYTSAYDIDAKDLIKAAAVRQKWIDQGQSLNVFLRIENASGKTLHDIYTLAW 755
Query: 1981 FLGCKGVTVYRDGSLSVQVYSV 2002
LG K R S S+ SV
Sbjct: 756 KLGLKSTYYLRSESPSIDEKSV 777
>sp|Q9ZLF9|RIR1_HELPJ RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE ALPHA CHAIN (RIBONUCLEOTIDE
REDUCTASE) >gi|7433359|pir||F71908
ribonucleoside-diphosphate reductase 1 alpha chain
[similarity] - Helicobacter pylori (strain J99)
>gi|4155174|gb|AAD06201.1| (AE001494)
RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 1 ALPHA CHAIN
[Helicobacter pylori J99]
Length = 788
Score = 90.9 bits (222), Expect = 1e-16
Identities = 85/322 (26%), Positives = 141/322 (43%), Gaps = 51/322 (15%)
Query: 1691 CNLASINLAKFVKYDENGKPYFDWDEYAYVIQKVAKYLDNSIDVNKFPLPEIDYNTKLTR 1750
CNLASINL+K + +E+ K V+ + + LDN ID+N +P ++ R
Sbjct: 497 CNLASINLSK-INTEEDIKR---------VVPIMVRLLDNVIDLNFYPNRKVKATNLQNR 546
Query: 1751 RIGVGMMGLADALFKLGIPYNSEEGFKFMRKVTEYLTFYAYKYSIEAAKKRGTFPLYEKT 1810
IG+G+MG A L + I + S+E + + + E ++++A S AK++G + +E +
Sbjct: 547 AIGLGVMGEAQMLAEHQIAWGSKEHLEKIDALMEQISYHAIDTSANLAKEKGVYKDFENS 606
Query: 1811 GYPKGELPVEGFYHPEI---------WNLPWDKLVEEIKKYGVRNAMVTTCPPTGSVSMI 1861
+ KG P++ + + W L E++K G+RN + PT S+S++
Sbjct: 607 EWSKGIFPIDKANNEALKLTEKGLFNHACDWQGLREKVKANGMRNGYLMAIAPTSSISIL 666
Query: 1862 ADTSSGIEPIFALVYKKSVTVGEFYYVDPVFEAELKRRGLYSEELLKKISDNYGSVQGLE 1921
T+ IEPI YKK FE L L+ + N
Sbjct: 667 VGTTQTIEPI----YKKK-----------WFEENL-------SGLIPVVVPN-------- 696
Query: 1922 EIPEDMRRVFVTALDIHWLDHLLAQANIQMWLTDSASKTINM-INEATVEDVKAAYLIAH 1980
+ + + +A DI D + A A Q W+ S + + I A+ + + Y +A
Sbjct: 697 -LNVETWNFYTSAYDIDAKDLIKAAAVRQKWIDQGQSINVFLRIENASGKTLHEIYTLAW 755
Query: 1981 FLGCKGVTVYRDGSLSVQVYSV 2002
LG K R S S+ SV
Sbjct: 756 KLGLKSTYYLRSESPSIDEKSV 777
>pir||B81101 ribonucleoside-diphosphate reductase, alpha chain NMB1291 [imported]
- Neisseria meningitidis (group B strain MD58)
>gi|7226531|gb|AAF41667.1| (AE002477)
ribonucleoside-diphosphate reductase, alpha subunit
[Neisseria meningitidis MC58]
Length = 759
Score = 87.8 bits (214), Expect = 1e-15
Identities = 61/217 (28%), Positives = 98/217 (45%), Gaps = 16/217 (7%)
Query: 1683 EPLYEYESCNLASINLAKFVKYDENGKPYFDWDEYAYVIQKVAKYLDNSIDVNKFPLPEI 1742
+P E C L++ NL DE + + LD +D +P+
Sbjct: 456 DPNGEIALCTLSAFNLGALNSLDE----------LEGLADLTVRALDALLDYQGYPVEAA 505
Query: 1743 DYNTKLTRRIGVGMMGLADALFKLGIPYNSEEGFKFMRKVTEYLTFYAYKYSIEAAKKRG 1802
+T R +G+G++ A L K G+ Y+ + E + +Y K S AK+ G
Sbjct: 506 RTSTMGRRSLGIGVINYAYYLAKNGVRYSDGSALGLTHRTFEAIQYYLLKASANLAKEYG 565
Query: 1803 TFPLYEKTGYPKGELPVEGFYHP------EIWNLPWDKLVEEIKKYGVRNAMVTTCPPTG 1856
L+ +T Y +G+LP++ + E + W+ L EI KYG+RN+ +T P+
Sbjct: 566 ACTLFNQTVYSQGKLPIDTYKKDLDAVCGEPLHYDWESLRAEIVKYGLRNSTLTALMPSE 625
Query: 1857 SVSMIADTSSGIEPIFALVYKKSVTVGEFYYVDPVFE 1893
+ S IA+ ++GIEP LV K+ G V P FE
Sbjct: 626 TSSQIANATNGIEPPRGLVTVKASKDGILKQVVPEFE 662
>pir||C82710 ribonucleoside-diphosphate reductase alpha chain XF1196 [imported] -
Xylella fastidiosa (strain 9a5c)
>gi|9106168|gb|AAF84006.1|AE003954_3 (AE003954)
ribonucleoside-diphosphate reductase alpha chain [Xylella
fastidiosa]
Length = 830
Score = 87.8 bits (214), Expect = 1e-15
Identities = 53/191 (27%), Positives = 96/191 (49%), Gaps = 9/191 (4%)
Query: 1687 EYESCNLASINLAKFVKYDENGKPYFDWDEYAYVIQKVAKYLDNSIDVNKFPLPEIDYNT 1746
++ CNL+SINL + + + D +I + LDN ID+N P+P+
Sbjct: 549 DFVVCNLSSINLGRAITVQAD---LLGADVLERLIPIQVRMLDNVIDLNLLPVPQATITN 605
Query: 1747 KLTRRIGVGMMGLADALFKLGIPYNSEEGFKFMRKVTEYLTFYAYKYSIEAAKKRGTFPL 1806
+ R IG+G G L + I +NS E ++ + E + + + S+E AK++GT+ +
Sbjct: 606 QKYRAIGLGTFGWHHLLAQKAIHWNSPEAEQYSDALYERINYLTIRASMELAKEKGTYAV 665
Query: 1807 YEKTGYPKGELPVEGFYHPEIWNLP-WDKLVEEIKKYGVRNAMVTTCPPTGSVSMIADTS 1865
+ + + GE ++ +N P W +L ++ GVRNA + P S + IA ++
Sbjct: 666 FPGSDWQTGE-----YFRARDYNSPQWLELAAQVAVNGVRNAYMVAVAPNMSTAQIAGST 720
Query: 1866 SGIEPIFALVY 1876
+ I+PI++ Y
Sbjct: 721 ASIDPIYSAFY 731
>gi|9625894 ORF19 (AA1-775) [Human herpesvirus 3] >gi|132612|sp|P09248|RIR1_VZVD
RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE CHAIN
(RIBONUCLEOTIDE REDUCTASE) >gi|66405|pir||WMBE19
ribonucleoside-diphosphate reductase (EC 1.17.4.1) large
chain - human herpesvirus 3 >gi|60008|emb|CAA27902.1|
(X04370) ORF19 (AA1-775) [Human herpesvirus 3]
Length = 775
Score = 87.4 bits (213), Expect = 2e-15
Identities = 59/222 (26%), Positives = 101/222 (44%), Gaps = 7/222 (3%)
Query: 1686 YEYESCNLASINLAKFVKYDENGKPYFDWDEYAYVIQKVAKYLDNSIDVNKFPLPEIDYN 1745
+++ CNLASINL + G F+ ++ + +L+ + FP +
Sbjct: 439 HQHGVCNLASINLTTCLS---KGPVSFNLNDLQLTARTTVIFLNGVLAAGNFPCKKSCKG 495
Query: 1746 TKLTRRIGVGMMGLADALFKLGIPYNSEEGFKFMRKVTEYLTFYAYKYSIEAAKKRGTFP 1805
K R +G+G+ GL +LG S+ + ++ E + + K S+E K G P
Sbjct: 496 VKNNRSLGIGIQGLHTTCLRLGFDLTSQPARRLNVQIAELMLYETMKTSMEMCKIGGLAP 555
Query: 1806 L--YEKTGYPKGELPVEGFYHPEIWNLPWDKLVEEIKKYGVRNAMVTTCPPTGSVSMIAD 1863
+ ++ Y KG L +GF +LPW L ++I YG+ N+ PT S + + +
Sbjct: 556 FKGFTESKYAKGWLHQDGFSTISYLDLPWCTLRDDICAYGLYNSQFLALMPTVSSAQVTE 615
Query: 1864 TSSGIEPIFALVYKKSVTVGEFYYVDPVFEAELKRRGLYSEE 1905
S G PI+ ++ K T GE + P + + R +YS E
Sbjct: 616 CSEGFSPIYNNMFSKVTTSGEL--LRPNLDLMDELRDMYSCE 655
>sp|P74240|RIR1_SYNY3 RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE ALPHA CHAIN (RIBONUCLEOTIDE
REDUCTASE) >gi|7433362|pir||S75875
ribonucleoside-diphosphate reductase (EC 1.17.4.1) alpha
chain [similarity] - Synechocystis sp. (strain PCC 6803)
>gi|1653420|dbj|BAA18334.1| (D90913) ribonucleotide
reductase subunit alpha [Synechocystis sp.]
Length = 767
Score = 87.0 bits (212), Expect = 2e-15
Identities = 57/194 (29%), Positives = 95/194 (48%), Gaps = 18/194 (9%)
Query: 1684 PLYEYESCNLASINLAKFVKYDENGKPYFDWDEYAYVIQKVAKYLDNSIDVNKFPLPEID 1743
P + CNL S+NLA D + A V Q + LDN+I++ P +
Sbjct: 471 PGQDAHCCNLVSLNLANL-----------DLQDIAGVSQIAVRMLDNTIELTAPPFADAK 519
Query: 1744 YNTKLTRRIGVGMMGLADALFKLGIPYNSEEGFKFMRKVTEYLTFYAYKYSIEAAKKRGT 1803
+ R IGVG MGLAD L K + Y+ + ++ E + ++ + S+E AK+RG
Sbjct: 520 SHNNKYRTIGVGAMGLADWLAKRRLNYDE---LADINRLFEEIGYWCTQSSMELAKERGA 576
Query: 1804 FPLYEKTGYPKGEL----PVEGFYHPEIWNLPWDKLVEEIKKYGVRNAMVTTCPPTGSVS 1859
+P + + + KG L PV F W+KL +I+ +G+RN+ +T P S S
Sbjct: 577 YPAFPGSDWQKGLLIGSKPVSWFQANAAKPERWEKLSNDIQTHGIRNSHITAIAPNTSSS 636
Query: 1860 MIADTSSGIEPIFA 1873
++ ++ I P+++
Sbjct: 637 LVQGCTASILPVYS 650
>sp|P57276|RIR1_BUCAI RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE ALPHA CHAIN (RIBONUCLEOTIDE
REDUCTASE) >gi|10038861|dbj|BAB12896.1| (AP001118)
ribonucleoside-diphosphate reductase 1 alpha chain
[Buchnera sp. APS]
Length = 761
Score = 87.0 bits (212), Expect = 2e-15
Identities = 68/238 (28%), Positives = 112/238 (46%), Gaps = 21/238 (8%)
Query: 1687 EYESCNLASINLAKFVKYDENGKPYFDWDEYAYVIQKVAKYLDNSIDVNKFPLPEIDYNT 1746
E C L++ NL K D D+ E + + + LD +D +P+ +
Sbjct: 458 EIALCTLSAFNLGKIKSLD-------DFKELSILSVRA---LDEILDYQNYPVLAAKKSA 507
Query: 1747 KLTRRIGVGMMGLADALFKLGIPYNSEEGFKFMRKVTEYLTFYAYKYSIEAAKKRGTFPL 1806
R +G+G++ A L K + Y+ K E + +Y + S E AK++G L
Sbjct: 508 ISRRSLGIGVINFAYYLAKNKVRYSDGSAHNLTHKTFEAMQYYLLEASCELAKEKGACSL 567
Query: 1807 YEKTGYPKGELPVEGF--YHPEIWNLP----WDKLVEEIKKYGVRNAMVTTCPPTGSVSM 1860
+ T Y G+LP++ + Y +I N P W+ L +IKKYG+RN+ ++ P+ + S
Sbjct: 568 FNHTNYYLGKLPIDTYKKYIDDICNEPLHLDWNLLRSKIKKYGLRNSTLSALMPSETSSQ 627
Query: 1861 IADTSSGIEPIFALVYKKSVTVGEFYYVDPVFEAELKRRGLYSEELLKKISDNYGSVQ 1918
I++ ++GIEP + K G V P ++ K R Y ELL I +N G +Q
Sbjct: 628 ISNATNGIEPPRGFISIKVSKDGILRQVVPEYK---KLRLQY--ELLWDIPNNTGYLQ 680
>pir||G81841 ribonucleoside-diphosphate reductase (EC 1.17.4.1) I alpha chain
NMA1501 [imported] - Neisseria meningitidis (group A
strain Z2491) >gi|7380149|emb|CAB84734.1| (AL162756)
ribonucleotide reductase I alpha chain [Neisseria
meningitidis Z2491]
Length = 759
Score = 86.6 bits (211), Expect = 3e-15
Identities = 60/217 (27%), Positives = 98/217 (44%), Gaps = 16/217 (7%)
Query: 1683 EPLYEYESCNLASINLAKFVKYDENGKPYFDWDEYAYVIQKVAKYLDNSIDVNKFPLPEI 1742
+P E C L++ NL DE + + LD +D +P+
Sbjct: 456 DPNGEIALCTLSAFNLGALNSLDE----------LEGLADLTVRALDALLDYQGYPVEAA 505
Query: 1743 DYNTKLTRRIGVGMMGLADALFKLGIPYNSEEGFKFMRKVTEYLTFYAYKYSIEAAKKRG 1802
+T R +G+G++ A L K G+ Y+ + E + +Y K S AK+ G
Sbjct: 506 RTSTMGRRSLGIGVINYAYYLAKNGVRYSDGSALGLTHRTFEAIQYYLLKASANLAKEYG 565
Query: 1803 TFPLYEKTGYPKGELPVEGFYHP------EIWNLPWDKLVEEIKKYGVRNAMVTTCPPTG 1856
L+ +T Y +G+LP++ + E + W+ L +I KYG+RN+ +T P+
Sbjct: 566 ACTLFNQTVYSQGKLPIDTYKKDLDAVCNEPLHYDWESLRADIVKYGLRNSTLTALMPSE 625
Query: 1857 SVSMIADTSSGIEPIFALVYKKSVTVGEFYYVDPVFE 1893
+ S IA+ ++GIEP LV K+ G V P FE
Sbjct: 626 TSSQIANATNGIEPPRGLVTVKASKDGILKQVVPEFE 662
>sp|P37426|RIR1_SALTY RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 1 ALPHA CHAIN (RIBONUCLEOTIDE
REDUCTASE 1) (B1 PROTEIN) (R1 PROTEIN)
>gi|421245|pir||S32629 ribonucleoside-diphosphate
reductase (EC 1.17.4.1) - Salmonella typhimurium
>gi|295896|emb|CAA51452.1| (X72948)
ribonucleoside-diphosphate reductase [Salmonella
typhimurium]
Length = 761
Score = 86.2 bits (210), Expect = 4e-15
Identities = 68/238 (28%), Positives = 111/238 (46%), Gaps = 21/238 (8%)
Query: 1687 EYESCNLASINLAKFVKYDENGKPYFDWDEYAYVIQKVAKYLDNSIDVNKFPLPEIDYNT 1746
E C L++ NL DE +E A + + LD +D +P+P
Sbjct: 458 EIALCTLSAFNLGAIKTLDE-------LEELAIL---AVRALDALLDYQDYPIPAAKRGA 507
Query: 1747 KLTRRIGVGMMGLADALFKLGIPYNSEEGFKFMRKVTEYLTFYAYKYSIEAAKKRGTFPL 1806
R +G+G++ A L K G Y+ K E + +Y K S E AK++G P
Sbjct: 508 MGRRTLGIGVINFAYWLAKNGKRYSDGSANNLTHKTFEAIQYYLLKASNELAKEQGACPW 567
Query: 1807 YEKTGYPKGELPVEGFYHP------EIWNLPWDKLVEEIKKYGVRNAMVTTCPPTGSVSM 1860
+ +T Y KG LP++ + E + W++L E IK +G+RN+ ++ P+ + S
Sbjct: 568 FNETTYAKGILPIDTYKKDLDAIVNEPLHYDWEQLRESIKTHGLRNSTLSALMPSETSSQ 627
Query: 1861 IADTSSGIEPIFALVYKKSVTVGEFYYVDPVFEAELKRRGLYSEELLKKISDNYGSVQ 1918
I++ ++GIEP V K+ G V P +E LK + ELL ++ +N G +Q
Sbjct: 628 ISNATNGIEPPRGYVSIKASKDGILRQVVPDYE-HLKD----AYELLWEMPNNDGYLQ 680
>emb|CAC12850.1| (AJ250333) DNA polymerase and endonucleases [Thermococcus sp. GE8]
Length = 1699
Score = 86.2 bits (210), Expect = 4e-15
Identities = 152/689 (22%), Positives = 274/689 (39%), Gaps = 135/689 (19%)
Query: 473 IPPKILRKGKNAVLSFITGLFDAEGHVNDKSGIELGMVNKKLIEAVTHYLNSLGIKARMR 532
+P I ++ +F G F +G ++ + L +++L+ + LNSLGI A
Sbjct: 849 VPEVIFTSPESVRWAFFEGYFIGDGDLHPSKRVRLSTKSEELVNGLVVLLNSLGISAIK- 907
Query: 533 EKRRKNGIDYIMHVEEYSSLLRFYELIGKHLQNNEKKEKLEILLHKHNGGAFDLSLNFNA 592
+RF + + L N E+L L ++ A+ +
Sbjct: 908 --------------------IRFDSGVYRVLVN----EELPFLGNRKRKNAYYSHVIPKE 943
Query: 593 FKEWASRYGVEFKTNGNQILAIIGNEKVSLGQWHARGHVSKAVLVKMLRKLYEVTKNDEV 652
E +G +F+ N + NEKV G+ A KA R++ + + D V
Sbjct: 944 ILE--ETFGKQFQKNMSPAKL---NEKVEKGELDA----GKA------RRIAWLLEGDIV 988
Query: 653 KEMLHLIESLEVVKEITITNEPKTFYDLTVDKYQNYLAGENGMIFVHNTGLNF------- 705
L+ V+++T+ + YDL+V++ +N+LAG GM++ HN+ +
Sbjct: 989 ---------LDRVEKVTVEDYEGYVYDLSVEENENFLAGF-GMLYAHNSYYGYYGYAKAR 1038
Query: 706 -------------------SKLRPEGDIVG-TTTGAACFTGDTRILTEKG----LIPIEE 741
+ +R + G A G+T ++ + +PIE+
Sbjct: 1039 WYCRECAESVTAWGRSYIETTIREIEEKFGFKVLYADSVAGNTEVIIRRNGKVEFVPIEK 1098
Query: 742 IVHETGKKPKVVTHAGLKDIIE-TYDNG----------------EMEVFRVTTEDGYELK 784
+ + + L+ + T DN +++RV + + L
Sbjct: 1099 LFQRVDYRIGEKEYCALEGVEALTLDNRGRLVWRKVPYIMRHKTNKKIYRVWFTNSWYLD 1158
Query: 785 VTGDHKFLVFDENGN-PTLKPLKELKVGDYVYILAPEWKGGEYVELDTNIELKGKGYNVN 843
VT DH + + + KPLKE V + P G + L T + N
Sbjct: 1159 VTEDHSLIGYLNTSKVKSEKPLKERLVE-----VKPRELGEKVKSLITLNRAIARSIKAN 1213
Query: 844 LPSKLDEKLAYLLGIIYADGHIRHYFENGKRKNSKIEIYLH--QDETEIKEKVKRYFKEI 901
+ +L L+G++ DG+ G K +K + L D+ EI+EKV R KE
Sbjct: 1214 ---PIAVRLWELIGLLVGDGNW-----GGHSKWAKYYVGLSCGLDKAEIEEKVLRPLKEA 1265
Query: 902 FGIEPKEFLKEEQHKVILVIPSTKIVKFLEINGLLKDKSENIRVPEAIFRSRPSVIAAFL 961
GI + K ++ V ++ S + F+ KD++ N R+P +F I AFL
Sbjct: 1266 -GIISNYYGKSKKGDVSIL--SKWLAGFMV--KYFKDENGNKRIPSFMFNLPREYIEAFL 1320
Query: 962 AGFFDGDGSIDQNY---RIAFKSISREFIKEAQLLFLALGIVTSIQEYNPPNP--NNKTV 1016
G F DG++ I S++RE E + L +G+ S+ PN N++
Sbjct: 1321 RGLFSADGTVSLRRGIPEIRLTSVNRELSNEVRKLLWLVGVSNSMFTETTPNKYLGNES- 1379
Query: 1017 YTLRVQTRDMKIKAFNVLKESVKLSKIMKEAISKLEENGK---NKKFSFPFNAIYHIKDP 1073
TR + ++ N + + ++ ++ +KL +N + NKK ++ ++ + + P
Sbjct: 1380 -----GTRSIHVRIKNKHRFAKRIGFLLDRKATKLSDNLREHTNKKMAYRYD--FDLVYP 1432
Query: 1074 KIRAKIQRDYKILSYNSKVTHRAFINNIL 1102
K +I D + + THR F N IL
Sbjct: 1433 KKIEEINYDRYVYDIEVEGTHRFFANGIL 1461
Score = 73.7 bits (178), Expect = 2e-11
Identities = 110/457 (24%), Positives = 179/457 (39%), Gaps = 74/457 (16%)
Query: 1384 KEVARVRTKEGYEITATLDHKLMTPEGWKEIKDLKP-------------GDKI---LLPR 1427
K++ RV + + T DH L+ ++K KP G+K+ +
Sbjct: 1144 KKIYRVWFTNSWYLDVTEDHSLIGYLNTSKVKSEKPLKERLVEVKPRELGEKVKSLITLN 1203
Query: 1428 FEVEEDFGSESIGEDLAFVLGWFIGDGYLNVKDKRAWFYFNAEKEEEIAWKIREILAKRF 1487
+ + I L ++G +GDG K A +Y + A ++L
Sbjct: 1204 RAIARSIKANPIAVRLWELIGLLVGDGNWGGHSKWAKYYVGLSCGLDKAEIEEKVLRPLK 1263
Query: 1488 EIKAEPHRYGNQIKLGVRGKAYEWLESIV------KTNEKRIPEIVYRLKPNEIASFLRG 1541
E + YG K G +WL + + KRIP ++ L I +FLRG
Sbjct: 1264 EAGIISNYYGKS-KKGDVSILSKWLAGFMVKYFKDENGNKRIPSFMFNLPREYIEAFLRG 1322
Query: 1542 LFSADGYVD---NDMAIRLTSKSRELLREVQDLLLLFGILSKIYERPYKREFKYTTKDGE 1598
LFSADG V IRLTS +REL EV+ LL L G+ + ++ KY +
Sbjct: 1323 LFSADGTVSLRRGIPEIRLTSVNRELSNEVRKLLWLVGVSNSMFTETTPN--KYLGNESG 1380
Query: 1599 ERTYTTEGYYELVIANYSRKIFAERIG-LEGYKMEKLS---------LEKIKVDEPIVTV 1648
R+ + I N R FA+RIG L K KLS + D +V
Sbjct: 1381 TRS------IHVRIKNKHR--FAKRIGFLLDRKATKLSDNLREHTNKKMAYRYDFDLVYP 1432
Query: 1649 ESVEILG-KKLVYDFTVPEHHMYISNGFMSHNC----GEEPLYEYESCNLASINLAKFVK 1703
+ +E + + VYD V H + +NG + HN P + E+ ++ K++
Sbjct: 1433 KKIEEINYDRYVYDIEVEGTHRFFANGILVHNTDGFFATIPGADAETVKKKAMEFLKYIN 1492
Query: 1704 YDENG-----------KPYFDWDEYAYVIQKVAKYLDNSIDVNKFPLPEIDYNTKLTRRI 1752
G + +F + VI + K +++ + EI T+
Sbjct: 1493 AKLPGLLELEYEGFYVRGFFVTKKKYAVIDEEGKITTRGLEIVRRDWSEIAKETQAR--- 1549
Query: 1753 GVGMMGLADALFKLGIPYNSEEGFKFMRKVTEYLTFY 1789
+ +A+ K G + EE + +++VTE L+ Y
Sbjct: 1550 ------VLEAILKHG---DVEEAVRIVKEVTEKLSKY 1577
>pdb|1RLR| Structure Of Ribonucleotide Reductase Protein R1
Length = 761
Score = 85.8 bits (209), Expect = 5e-15
Identities = 61/213 (28%), Positives = 97/213 (44%), Gaps = 16/213 (7%)
Query: 1687 EYESCNLASINLAKFVKYDENGKPYFDWDEYAYVIQKVAKYLDNSIDVNKFPLPEIDYNT 1746
E C L++ NL DE DE A + + LD +D +P+P
Sbjct: 458 EIALCTLSAFNLGAINNLDE-------LDELAIL---AVRALDALLDYQDYPIPAAKRGA 507
Query: 1747 KLTRRIGVGMMGLADALFKLGIPYNSEEGFKFMRKVTEYLTFYAYKYSIEAAKKRGTFPL 1806
R +G+G++ A L K G Y+ K E + +Y K S E AK++G P
Sbjct: 508 MGRRTLGIGVINFAYYLAKHGKRYSDGSANNLTHKTFEAIQYYLLKASNELAKEQGACPW 567
Query: 1807 YEKTGYPKGELPVEGFYHP------EIWNLPWDKLVEEIKKYGVRNAMVTTCPPTGSVSM 1860
+ +T Y KG LP++ + E + W+ L E IK +G+RN+ ++ P+ + S
Sbjct: 568 FNETTYAKGILPIDTYKKDLDTIANEPLHYDWEALRESIKTHGLRNSTLSALMPSETSSQ 627
Query: 1861 IADTSSGIEPIFALVYKKSVTVGEFYYVDPVFE 1893
I++ ++GIEP V K+ G V P +E
Sbjct: 628 ISNATNGIEPPRGYVSIKASKDGILRQVVPDYE 660
>sp|Q58815|YE20_METJA HYPOTHETICAL PROTEIN MJ1420 >gi|2127939|pir||C64477
glutamine--fructose-6-phosphate transaminase
(isomerizing) (EC 2.6.1.16) (intein-containing) -
Methanococcus jannaschii >gi|1592069|gb|AAB99430.1|
(U67582) glucosamine--fructose-6-phosphate
aminotransferase (isomerizing) (glmS) [Methanococcus
jannaschii]
Length = 1102
Score = 85.0 bits (207), Expect = 8e-15
Identities = 89/326 (27%), Positives = 143/326 (43%), Gaps = 25/326 (7%)
Query: 842 VNLPSKLDEKLAYLLGIIYADGHIRHYFENGKRKNSKIEIYLHQDETEIKEKVKRYFKEI 901
V P +L ++G I DGH S + L + E+ E+ + FK +
Sbjct: 268 VKFPKTPTPELMQIIGYIIGDGHFP----------SNRMLRLKDERKEVLEEYNQLFKTV 317
Query: 902 FGIEPKEFLKEEQHKVILVIPSTKIVKFLEIN-GLLKDKSENIRVPEAIFRSRPSVIAAF 960
F +E K + + IL I S ++ + N L +K+ N R PE +FR ++A++
Sbjct: 318 FNLEGN-IKKGDGNYYILEINSKYLIDWFRENIPELFNKTGNERTPEFVFRLNNDLVASY 376
Query: 961 LAGFFDGDGSI-DQNYRIAFKSISREFIKEAQLLFLALGIVTSIQEYNPPNPNNKTVYTL 1019
L G FD +G I + +I S+ FIKE Q L L GI+ S + N + L
Sbjct: 377 LRGIFDAEGYIRAEAKQIGIGMTSKCFIKEIQFLLLRFGILASYSKIKRKEENWNNTHKL 436
Query: 1020 RVQTRDMKIKAFNVLKESVKLSKIMKEAISKLEE-NGKNKKFSFPFNAIYHIKDPKIRAK 1078
+ + K+F + K+ + + K+ + KLE K K +F + +I + +IR
Sbjct: 437 LISDK----KSFELFKKYIGFT--AKDKMEKLEAILNKMKGLNFRYISI-PLTKKEIREF 489
Query: 1079 IQRDYKILSYNSKVTHRAFINNILKLKEELGLDD--EEVKYFEMLSKLYPT-KITKIEPL 1135
+ K + I I++ GL D E +K F ++ KI ++E
Sbjct: 490 VGVPLKTIKNGDNYCTDYTIEKIIEELNSKGLYDKAEYLKRFLDADIVWTKFKIEEVES- 548
Query: 1136 GKAHVYDLQVEDVHLLTGNGIYTSNS 1161
+VYDL+VED H GN I NS
Sbjct: 549 DVEYVYDLEVEDYHNFIGNLIINHNS 574
>gb|AAB66912.1| (AF006675) DNA helicase [Rhodothermus marinus]
Length = 941
Score = 85.0 bits (207), Expect = 8e-15
Identities = 61/222 (27%), Positives = 105/222 (46%), Gaps = 28/222 (12%)
Query: 1382 GMKEVARVRTKEGYEITATLDHKLMTPEGWKEIKDLKPGDKILLPRFEVEEDFGSESIGE 1441
G+K V R+ T+ G I AT +H+ +TP+GWK + +L+PGD + LPR + ++ E
Sbjct: 472 GIKPVYRLTTRLGRSIRATANHRFLTPQGWKRVDELQPGDYLALPR--RIPTASTPTLTE 529
Query: 1442 DLAFVLGWFIGDGYLNVKDKRAWFYFNAEKEEEIAWKIREILAKRFEIKAEPH------- 1494
+LG IGDG + ++ ++A + + K F K P
Sbjct: 530 AELALLGHLIGDGCTLPHHVIQY----TSRDADLATLVAHLATKVFGSKVTPQIRKELRW 585
Query: 1495 -----RYGNQIKLGVRGKAYEWLESI----VKTNEKRIPEIVYRLKPNEIASFLRGLFSA 1545
R + G R +WL + +++ EK++P +++ IA+FLR L++
Sbjct: 586 YQVYLRAARPLAPGKRNPISDWLRDLGIFGLRSYEKKVPALLFCQTSEAIATFLRHLWAT 645
Query: 1546 DGYVDNDM------AIRLTSKSRELLREVQDLLLLFGILSKI 1581
DG + A+ + S +L R+VQ LLL GI +++
Sbjct: 646 DGCIQMRRGKKPYPAVYYATSSYQLARDVQSLLLRLGINARL 687
>emb|CAA74140.1| (Y13813) helicase [Rhodothermus marinus]
Length = 945
Score = 85.0 bits (207), Expect = 8e-15
Identities = 61/222 (27%), Positives = 105/222 (46%), Gaps = 28/222 (12%)
Query: 1382 GMKEVARVRTKEGYEITATLDHKLMTPEGWKEIKDLKPGDKILLPRFEVEEDFGSESIGE 1441
G+K V R+ T+ G I AT +H+ +TP+GWK + +L+PGD + LPR + ++ E
Sbjct: 476 GIKPVYRLTTRLGRSIRATANHRFLTPQGWKRVDELQPGDYLALPR--RIPTASTPTLTE 533
Query: 1442 DLAFVLGWFIGDGYLNVKDKRAWFYFNAEKEEEIAWKIREILAKRFEIKAEPH------- 1494
+LG IGDG + ++ ++A + + K F K P
Sbjct: 534 AELALLGHLIGDGCTLPHHVIQY----TSRDADLATLVAHLATKVFGSKVTPQIRKELRW 589
Query: 1495 -----RYGNQIKLGVRGKAYEWLESI----VKTNEKRIPEIVYRLKPNEIASFLRGLFSA 1545
R + G R +WL + +++ EK++P +++ IA+FLR L++
Sbjct: 590 YQVYLRAARPLAPGKRNPISDWLRDLGIFGLRSYEKKVPALLFCQTSEAIATFLRHLWAT 649
Query: 1546 DGYVDNDM------AIRLTSKSRELLREVQDLLLLFGILSKI 1581
DG + A+ + S +L R+VQ LLL GI +++
Sbjct: 650 DGCIQMRRGKKPYPAVYYATSSYQLARDVQSLLLRLGINARL 691
>sp|P00452|RIR1_ECOLI RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 1 ALPHA CHAIN (RIBONUCLEOTIDE
REDUCTASE 1) (B1 PROTEIN) (R1 PROTEIN)
>gi|7427852|pir||RDEC1R ribonucleoside-diphosphate
reductase (EC 1.17.4.1) 1 alpha chain [validated] -
Escherichia coli >gi|2914311|pdb|2R1R|A Chain A,
Ribonucleotide Reductase R1 Protein With Dttp Occupying
The Specificity Site From Escherichia Coli
>gi|2914313|pdb|2R1R|B Chain B, Ribonucleotide Reductase
R1 Protein With Dttp Occupying The Specificity Site From
Escherichia Coli >gi|2914315|pdb|2R1R|C Chain C,
Ribonucleotide Reductase R1 Protein With Dttp Occupying
The Specificity Site From Escherichia Coli
>gi|2914218|pdb|3R1R|A Chain A, Ribonucleotide Reductase
R1 Protein With Amppnp Occupying The Activity Site From
Escherichia Coli >gi|2914220|pdb|3R1R|B Chain B,
Ribonucleotide Reductase R1 Protein With Amppnp Occupying
The Activity Site From Escherichia Coli
>gi|2914222|pdb|3R1R|C Chain C, Ribonucleotide Reductase
R1 Protein With Amppnp Occupying The Activity Site From
Escherichia Coli >gi|1799581|dbj|BAA16053.1| (D90855)
RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 1 ALPHA CHAIN (EC
1.17.4.1) (RIBONUCLEOTIDE REDUCTASE 1) (B1 PROTEIN) (R1
PROTEIN). [Escherichia coli] >gi|2367133|gb|AAC75294.1|
(AE000313) ribonucleoside diphosphate reductase 1, alpha
subunit, B1 [Escherichia coli K12]
Length = 761
Score = 84.3 bits (205), Expect = 1e-14
Identities = 60/213 (28%), Positives = 97/213 (45%), Gaps = 16/213 (7%)
Query: 1687 EYESCNLASINLAKFVKYDENGKPYFDWDEYAYVIQKVAKYLDNSIDVNKFPLPEIDYNT 1746
E C L++ NL DE +E A + + LD +D +P+P
Sbjct: 458 EIALCTLSAFNLGAINNLDE-------LEELAIL---AVRALDALLDYQDYPIPAAKRGA 507
Query: 1747 KLTRRIGVGMMGLADALFKLGIPYNSEEGFKFMRKVTEYLTFYAYKYSIEAAKKRGTFPL 1806
R +G+G++ A L K G Y+ K E + +Y K S E AK++G P
Sbjct: 508 MGRRTLGIGVINFAYYLAKHGKRYSDGSANNLTHKTFEAIQYYLLKASNELAKEQGACPW 567
Query: 1807 YEKTGYPKGELPVEGFYHP------EIWNLPWDKLVEEIKKYGVRNAMVTTCPPTGSVSM 1860
+ +T Y KG LP++ + E + W+ L E IK +G+RN+ ++ P+ + S
Sbjct: 568 FNETTYAKGILPIDTYKKDLDTIANEPLHYDWEALRESIKTHGLRNSTLSALMPSETSSQ 627
Query: 1861 IADTSSGIEPIFALVYKKSVTVGEFYYVDPVFE 1893
I++ ++GIEP V K+ G V P +E
Sbjct: 628 ISNATNGIEPPRGYVSIKASKDGILRQVVPDYE 660
>pdb|4R1R|A Chain A, Ribonucleotide Reductase R1 Protein With Substrate, Gdp And
Effector Dttp From Escherichia Coli
>gi|2914236|pdb|4R1R|B Chain B, Ribonucleotide Reductase
R1 Protein With Substrate, Gdp And Effector Dttp From
Escherichia Coli >gi|2914238|pdb|4R1R|C Chain C,
Ribonucleotide Reductase R1 Protein With Substrate, Gdp
And Effector Dttp From Escherichia Coli
Length = 761
Score = 84.3 bits (205), Expect = 1e-14
Identities = 60/213 (28%), Positives = 97/213 (45%), Gaps = 16/213 (7%)
Query: 1687 EYESCNLASINLAKFVKYDENGKPYFDWDEYAYVIQKVAKYLDNSIDVNKFPLPEIDYNT 1746
E C L++ NL DE +E A + + LD +D +P+P
Sbjct: 458 EIALCTLSAFNLGAINNLDE-------LEELAIL---AVRALDALLDYQDYPIPAAKRGA 507
Query: 1747 KLTRRIGVGMMGLADALFKLGIPYNSEEGFKFMRKVTEYLTFYAYKYSIEAAKKRGTFPL 1806
R +G+G++ A L K G Y+ K E + +Y K S E AK++G P
Sbjct: 508 MGRRTLGIGVINFAYYLAKHGKRYSDGSANNLTHKTFEAIQYYLLKASNELAKEQGACPW 567
Query: 1807 YEKTGYPKGELPVEGFYHP------EIWNLPWDKLVEEIKKYGVRNAMVTTCPPTGSVSM 1860
+ +T Y KG LP++ + E + W+ L E IK +G+RN+ ++ P+ + S
Sbjct: 568 FNETTYAKGILPIDTYKKDLDTIANEPLHYDWEALRESIKTHGLRNSTLSALMPSETSSQ 627
Query: 1861 IADTSSGIEPIFALVYKKSVTVGEFYYVDPVFE 1893
I++ ++GIEP V K+ G V P +E
Sbjct: 628 ISNATNGIEPPRGYVSIKASKDGILRQVVPDYE 660
>pdb|1R1R|A Chain A, Ribonucleotide Reductase R1 Protein Mutant Y730f With A
Reduced Active Site From Escherichia Coli
>gi|2914262|pdb|1R1R|B Chain B, Ribonucleotide Reductase
R1 Protein Mutant Y730f With A Reduced Active Site From
Escherichia Coli >gi|2914264|pdb|1R1R|C Chain C,
Ribonucleotide Reductase R1 Protein Mutant Y730f With A
Reduced Active Site From Escherichia Coli
Length = 761
Score = 84.3 bits (205), Expect = 1e-14
Identities = 60/213 (28%), Positives = 97/213 (45%), Gaps = 16/213 (7%)
Query: 1687 EYESCNLASINLAKFVKYDENGKPYFDWDEYAYVIQKVAKYLDNSIDVNKFPLPEIDYNT 1746
E C L++ NL DE +E A + + LD +D +P+P
Sbjct: 458 EIALCTLSAFNLGAINNLDE-------LEELAIL---AVRALDALLDYQDYPIPAAKRGA 507
Query: 1747 KLTRRIGVGMMGLADALFKLGIPYNSEEGFKFMRKVTEYLTFYAYKYSIEAAKKRGTFPL 1806
R +G+G++ A L K G Y+ K E + +Y K S E AK++G P
Sbjct: 508 MGRRTLGIGVINFAYYLAKHGKRYSDGSANNLTHKTFEAIQYYLLKASNELAKEQGACPW 567
Query: 1807 YEKTGYPKGELPVEGFYHP------EIWNLPWDKLVEEIKKYGVRNAMVTTCPPTGSVSM 1860
+ +T Y KG LP++ + E + W+ L E IK +G+RN+ ++ P+ + S
Sbjct: 568 FNETTYAKGILPIDTYKKDLDTIANEPLHYDWEALRESIKTHGLRNSTLSALMPSETSSQ 627
Query: 1861 IADTSSGIEPIFALVYKKSVTVGEFYYVDPVFE 1893
I++ ++GIEP V K+ G V P +E
Sbjct: 628 ISNATNGIEPPRGYVSIKASKDGILRQVVPDYE 660
>pdb|5R1R|A Chain A, Ribonucleotide Reductase E441a Mutant R1 Protein From
Escherichia Coli >gi|2981913|pdb|5R1R|B Chain B,
Ribonucleotide Reductase E441a Mutant R1 Protein From
Escherichia Coli >gi|2981915|pdb|5R1R|C Chain C,
Ribonucleotide Reductase E441a Mutant R1 Protein From
Escherichia Coli
Length = 761
Score = 84.3 bits (205), Expect = 1e-14
Identities = 60/213 (28%), Positives = 97/213 (45%), Gaps = 16/213 (7%)
Query: 1687 EYESCNLASINLAKFVKYDENGKPYFDWDEYAYVIQKVAKYLDNSIDVNKFPLPEIDYNT 1746
E C L++ NL DE +E A + + LD +D +P+P
Sbjct: 458 EIALCTLSAFNLGAINNLDE-------LEELAIL---AVRALDALLDYQDYPIPAAKRGA 507
Query: 1747 KLTRRIGVGMMGLADALFKLGIPYNSEEGFKFMRKVTEYLTFYAYKYSIEAAKKRGTFPL 1806
R +G+G++ A L K G Y+ K E + +Y K S E AK++G P
Sbjct: 508 MGRRTLGIGVINFAYYLAKHGKRYSDGSANNLTHKTFEAIQYYLLKASNELAKEQGACPW 567
Query: 1807 YEKTGYPKGELPVEGFYHP------EIWNLPWDKLVEEIKKYGVRNAMVTTCPPTGSVSM 1860
+ +T Y KG LP++ + E + W+ L E IK +G+RN+ ++ P+ + S
Sbjct: 568 FNETTYAKGILPIDTYKKDLDTIANEPLHYDWEALRESIKTHGLRNSTLSALMPSETSSQ 627
Query: 1861 IADTSSGIEPIFALVYKKSVTVGEFYYVDPVFE 1893
I++ ++GIEP V K+ G V P +E
Sbjct: 628 ISNATNGIEPPRGYVSIKASKDGILRQVVPDYE 660
>pdb|6R1R|A Chain A, Ribonucleotide Reductase E441d Mutant R1 Protein From
Escherichia Coli >gi|2981921|pdb|6R1R|B Chain B,
Ribonucleotide Reductase E441d Mutant R1 Protein From
Escherichia Coli >gi|2981923|pdb|6R1R|C Chain C,
Ribonucleotide Reductase E441d Mutant R1 Protein From
Escherichia Coli
Length = 761
Score = 84.3 bits (205), Expect = 1e-14
Identities = 60/213 (28%), Positives = 97/213 (45%), Gaps = 16/213 (7%)
Query: 1687 EYESCNLASINLAKFVKYDENGKPYFDWDEYAYVIQKVAKYLDNSIDVNKFPLPEIDYNT 1746
E C L++ NL DE +E A + + LD +D +P+P
Sbjct: 458 EIALCTLSAFNLGAINNLDE-------LEELAIL---AVRALDALLDYQDYPIPAAKRGA 507
Query: 1747 KLTRRIGVGMMGLADALFKLGIPYNSEEGFKFMRKVTEYLTFYAYKYSIEAAKKRGTFPL 1806
R +G+G++ A L K G Y+ K E + +Y K S E AK++G P
Sbjct: 508 MGRRTLGIGVINFAYYLAKHGKRYSDGSANNLTHKTFEAIQYYLLKASNELAKEQGACPW 567
Query: 1807 YEKTGYPKGELPVEGFYHP------EIWNLPWDKLVEEIKKYGVRNAMVTTCPPTGSVSM 1860
+ +T Y KG LP++ + E + W+ L E IK +G+RN+ ++ P+ + S
Sbjct: 568 FNETTYAKGILPIDTYKKDLDTIANEPLHYDWEALRESIKTHGLRNSTLSALMPSETSSQ 627
Query: 1861 IADTSSGIEPIFALVYKKSVTVGEFYYVDPVFE 1893
I++ ++GIEP V K+ G V P +E
Sbjct: 628 ISNATNGIEPPRGYVSIKASKDGILRQVVPDYE 660
>pdb|7R1R|A Chain A, Ribonucleotide Reductase E441q Mutant R1 Protein From
Escherichia Coli >gi|2981930|pdb|7R1R|B Chain B,
Ribonucleotide Reductase E441q Mutant R1 Protein From
Escherichia Coli >gi|2981932|pdb|7R1R|C Chain C,
Ribonucleotide Reductase E441q Mutant R1 Protein From
Escherichia Coli
Length = 761
Score = 84.3 bits (205), Expect = 1e-14
Identities = 60/213 (28%), Positives = 97/213 (45%), Gaps = 16/213 (7%)
Query: 1687 EYESCNLASINLAKFVKYDENGKPYFDWDEYAYVIQKVAKYLDNSIDVNKFPLPEIDYNT 1746
E C L++ NL DE +E A + + LD +D +P+P
Sbjct: 458 EIALCTLSAFNLGAINNLDE-------LEELAIL---AVRALDALLDYQDYPIPAAKRGA 507
Query: 1747 KLTRRIGVGMMGLADALFKLGIPYNSEEGFKFMRKVTEYLTFYAYKYSIEAAKKRGTFPL 1806
R +G+G++ A L K G Y+ K E + +Y K S E AK++G P
Sbjct: 508 MGRRTLGIGVINFAYYLAKHGKRYSDGSANNLTHKTFEAIQYYLLKASNELAKEQGACPW 567
Query: 1807 YEKTGYPKGELPVEGFYHP------EIWNLPWDKLVEEIKKYGVRNAMVTTCPPTGSVSM 1860
+ +T Y KG LP++ + E + W+ L E IK +G+RN+ ++ P+ + S
Sbjct: 568 FNETTYAKGILPIDTYKKDLDTIANEPLHYDWEALRESIKTHGLRNSTLSALMPSETSSQ 627
Query: 1861 IADTSSGIEPIFALVYKKSVTVGEFYYVDPVFE 1893
I++ ++GIEP V K+ G V P +E
Sbjct: 628 ISNATNGIEPPRGYVSIKASKDGILRQVVPDYE 660
>sp|O83972|RIR1_TREPA RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE ALPHA CHAIN (RIBONUCLEOTIDE
REDUCTASE) >gi|7433361|pir||B71255
ribonucleoside-diphosphate reductase (EC 1.17.4.1) alpha
chain [similarity] - syphilis spirochete
>gi|3323332|gb|AAC65956.1| (AE001268)
ribonucleoside-diphosphate reductase, subunit alpha
(nrdA) [Treponema pallidum]
Length = 845
Score = 84.3 bits (205), Expect = 1e-14
Identities = 59/227 (25%), Positives = 104/227 (44%), Gaps = 32/227 (14%)
Query: 1645 IVTVESVEILGKKLVYDFTVPEHHMYISNGFMSHNCGEEPLYEYESCNLASINLAKFVKY 1704
+V+V+ E+ G+K+V T P ++ CNLAS+ L+
Sbjct: 548 LVSVKITEVDGQKVVVQTTRPG--------------------DFVVCNLASLVLSNIDLS 587
Query: 1705 DENGKPYFDWDEYAYVIQKVAKYLDNSIDVNKFPLPEIDYNTKLTRRIGVGMMGLADALF 1764
D+ E V++ + LDN ID+ +P+P R IG+G+ G L
Sbjct: 588 DDK--------ELREVVRVAVRALDNVIDLTYYPVPYAQVTNAYYRAIGLGVSGYHHVLA 639
Query: 1765 KLGIPYNSEEGFKFMRKVTEYLTFYAYKYSIEAAKKRGTFPLYEKTGYPKGELPVEGFYH 1824
+ GI + S+E F ++ E + A + S+ A+++G + + + + G + Y
Sbjct: 640 QQGIDWESDEHLAFADRIFERINRAAIEASMTIAREKGAYGCFTGSDWCTGAYFRKRGYV 699
Query: 1825 PEIWNLPWDKLVEEIKKYGVRNAMVTTCPPTGSVSMIADTSSGIEPI 1871
E W +L E+ +G+RN + PT S S+IA T++G++PI
Sbjct: 700 SE----DWQRLQREVATHGMRNGYLLAVAPTSSTSIIAGTTAGVDPI 742
>sp|Q58242|Y832_METJA HYPOTHETICAL PROTEIN MJ0832 >gi|2129243|pir||H64403
ribonucleoside-triphosphate reductase (EC 1.17.4.2),
anaerobic (intein-containing) - Methanococcus jannaschii
>gi|1591520|gb|AAB98834.1| (U67527) anaerobic
ribonucleoside-triphosphate reductase (nrdD)
[Methanococcus jannaschii]
Length = 1750
Score = 83.9 bits (204), Expect = 2e-14
Identities = 100/406 (24%), Positives = 179/406 (43%), Gaps = 47/406 (11%)
Query: 771 EVFRVTTEDGYELKVTGDHKFLVFDENGNPTLKPLKELK--VGDYVYILAPEWKGGEYVE 828
+V++V +DG + VT DH +DENGN +++K + ++ E++ G+Y+E
Sbjct: 418 KVYKVIGKDGTSIIVTEDHSLFNYDENGNLVCVKPRQMKHIIRNFNNPYDVEYRIGDYIE 477
Query: 829 LDTNIELKGKGYNV---NLPSKLD--EKLAYLLGIIYADGHIRHYFENGKRKNSKIEIYL 883
TN + YN ++P KL ++L LG+ A+G Y NG I +
Sbjct: 478 --TNYQRTDSKYNSRQNDIPEKLKITKELCQFLGLFVAEGS---YITNG--------ISI 524
Query: 884 HQDETEIKEKVKRYFKEIFGIEPKEFLKEEQHKVILVIPSTKIVKFLE--INGLLKDKSE 941
+ +I + ++R+ KE + E + ++++ + + +FL+ ING K+
Sbjct: 525 TTKDDDIAKFIERFVKE----QINENIAVKRYEDSVRFVNKGFYRFLKEHING----KAI 576
Query: 942 NIRVPEAIFRSRPSVIAAFLAGFFDGDGSIDQNYRIAFKSISREFIKEAQLLFLALGIVT 1001
N PE I + + AFL G GDG + ++ R+ + S + + + LL LG++
Sbjct: 577 NKNSPEFILKGDKEMKLAFLGGLISGDGYVSKDGRVQIYTTSEQLLGQLHLLLSDLGMIY 636
Query: 1002 SIQEYNPPN-----PNNKTVYTLRVQTRDMKIKAFNVLKESVKLSKIMKEAISKLEENGK 1056
SI + N+ V ++ ++ LK V + K KE I +
Sbjct: 637 SITKIKEEGEKIEIKRNEIVRNYKLYVIEIAKNCTEDLKPYV-IPKYKKERIKPANYDQL 695
Query: 1057 NKKFSFPFNAIYHIKDPKIRAKIQRDYKILSYNSKVTHRAFINNILKLKEELGLDDEEVK 1116
+ + I D K DY S N K+ +N + K+++ EE+
Sbjct: 696 PYDYRIIKEHLRKITD----KKPYNDYAWKSNNRKLK----LNTLEKIEQLNPHLREEIN 747
Query: 1117 YFEMLSKLYPTKITKIEPLGKAHVYDLQVED-VHLLTGNGIYTSNS 1161
F++ +I +I+ G +VYDL VED + +T GI N+
Sbjct: 748 KFKLNIPFEIKEIKEIDYNG--YVYDLSVEDNENFITATGILCHNT 791
>sp|P50642|RIR1_HSVE4 RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE CHAIN (RIBONUCLEOTIDE
REDUCTASE) >gi|515832|emb|CAA53100.1| (X75354)
ribonucleotide reductase large subunit [Equine
herpesvirus 4]
Length = 789
Score = 83.1 bits (202), Expect = 3e-14
Identities = 53/199 (26%), Positives = 91/199 (45%), Gaps = 5/199 (2%)
Query: 1691 CNLASINLAKFVKYDEN---GKPYFDWDEYAYVIQKVAKYLDNSIDVNKFPLPEIDYNTK 1747
CNLASINL K + G PYFD+ +++ + + +P + +
Sbjct: 452 CNLASINLPKCLALPPPNIAGVPYFDFAALGRAAATATIFVNAMMCASTYPTVKSQKGVE 511
Query: 1748 LTRRIGVGMMGLADALFKLGIPYNSEEGFKFMRKVTEYLTFYAYKYSIEAAKK-RGTFPL 1806
R +G+G+ GL L + S E + +++ E L + K S K F
Sbjct: 512 ENRSLGLGIQGLHTTFLMLDLDMASPEAHQLNKQIAERLLLNSMKASATLCKLGMQPFKG 571
Query: 1807 YEKTGYPKGELPVEGFYHPEIWNL-PWDKLVEEIKKYGVRNAMVTTCPPTGSVSMIADTS 1865
+E + Y +GELP + + + + N W +L +IK+YG+ N+ PT S S + ++S
Sbjct: 572 FEDSKYSRGELPFDAYPNVTLTNRNAWRRLRTDIKQYGLYNSQFVAYMPTVSSSQVTESS 631
Query: 1866 SGIEPIFALVYKKSVTVGE 1884
G P++ ++ K GE
Sbjct: 632 EGFSPVYTNLFSKVTATGE 650
>gi|9629746 21 [Equine herpesvirus 4] >gi|11256458|pir||T42564
ribonucleoside-diphosphate reductase (EC 1.17.4.1) large
chain - equine herpesvirus 4 (strain NS80567)
>gi|2605964|gb|AAC59536.1| (AF030027) 21 [Equine
herpesvirus 4]
Length = 789
Score = 83.1 bits (202), Expect = 3e-14
Identities = 53/199 (26%), Positives = 91/199 (45%), Gaps = 5/199 (2%)
Query: 1691 CNLASINLAKFVKYDEN---GKPYFDWDEYAYVIQKVAKYLDNSIDVNKFPLPEIDYNTK 1747
CNLASINL K + G PYFD+ +++ + + +P + +
Sbjct: 452 CNLASINLPKCLALPPPNIAGVPYFDFAALGRAAATATIFVNAMMCASTYPTVKSQKGVE 511
Query: 1748 LTRRIGVGMMGLADALFKLGIPYNSEEGFKFMRKVTEYLTFYAYKYSIEAAKK-RGTFPL 1806
R +G+G+ GL L + S E + +++ E L + K S K F
Sbjct: 512 ENRSLGLGIQGLHTTFLMLDLDMASPEAHQLNKQIAERLLLNSMKASATLCKLGMQPFKG 571
Query: 1807 YEKTGYPKGELPVEGFYHPEIWNL-PWDKLVEEIKKYGVRNAMVTTCPPTGSVSMIADTS 1865
+E + Y +GELP + + + + N W +L +IK+YG+ N+ PT S S + ++S
Sbjct: 572 FEDSKYSRGELPFDAYPNVTLTNRNAWRRLRTDIKQYGLYNSQFVAYMPTVSSSQVTESS 631
Query: 1866 SGIEPIFALVYKKSVTVGE 1884
G P++ ++ K GE
Sbjct: 632 EGFSPVYTNLFSKVTATGE 650
>gi|9629420 ribonucleotide reductase large subunit [human herpesvirus 1]
>gi|132605|sp|P08543|RIR1_HSV11
RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE CHAIN
(RIBONUCLEOTIDE REDUCTASE) (136 KD SUBUNIT)
>gi|59539|emb|CAA32314.1| (X14112) ribonucleotide
reductase large subunit [human herpesvirus 1]
>gi|221760|dbj|BAA01685.1| (D10879) large subunit of
ribonucleotide reductase [human herpesvirus 1]
Length = 1137
Score = 82.7 bits (201), Expect = 4e-14
Identities = 73/273 (26%), Positives = 122/273 (43%), Gaps = 22/273 (8%)
Query: 1658 LVYDFTVPEHHMYISNGFM---SHNCGE--EPLYEYES--CNLASINLAKFVKYDENGKP 1710
+++ V H++Y + G S+ C E P + S CNL S+NLA+ V +
Sbjct: 768 VMFKDAVNRHYIYDTQGAAIAGSNLCTEIVHPASKRSSGVCNLGSVNLARCVS-----RQ 822
Query: 1711 YFDWDEYAYVIQKVAKYLDNSIDVNKFPLPEIDYNTKLTRRIGVGMMGLADALFKLGIPY 1770
FD+ +Q ++ ID P P+ R +G+GM GL A KLG+
Sbjct: 823 TFDFGRLRDAVQACVLMVNIMIDSTLQPTPQCTRGNDNLRSMGIGMQGLHTACLKLGLDL 882
Query: 1771 NSEEGFKFMRKVTEYLTFYAYKYSIEAAKKRGTFPL--YEKTGYPKGELPVEGFYHPEI- 1827
S E + + E + A K S A RG P ++++ Y G E F P+
Sbjct: 883 ESAEFQDLNKHIAEVMLLSAMKTS-NALCVRGARPFNHFKRSMYRAGRFHWERF--PDAR 939
Query: 1828 --WNLPWDKLVEEIKKYGVRNAMVTTCPPTGSVSMIADTSSGIEPIFALVYKKSVTVGEF 1885
+ W+ L + + K+G+RN+ PT + + I+D S G P+F ++ K GE
Sbjct: 940 PRYEGEWEMLRQSMMKHGLRNSQFVALMPTAASAQISDVSEGFAPLFTNLFSKVTRDGET 999
Query: 1886 YYVDPVFEAELKRRGLYSEELLKKISDNYGSVQ 1918
+ + EL+R +S + L ++ D+ + Q
Sbjct: 1000 LRPNTLLLKELER--TFSGKRLLEVMDSLDAKQ 1030
>pir||WMBEB1 ribonucleoside-diphosphate reductase (EC 1.17.4.1) large chain -
human herpesvirus 1 >gi|225644|prf||1308225A
ribonucleotide reductase [Human herpesvirus 1]
Length = 1137
Score = 82.7 bits (201), Expect = 4e-14
Identities = 73/273 (26%), Positives = 122/273 (43%), Gaps = 22/273 (8%)
Query: 1658 LVYDFTVPEHHMYISNGFM---SHNCGE--EPLYEYES--CNLASINLAKFVKYDENGKP 1710
+++ V H++Y + G S+ C E P + S CNL S+NLA+ V +
Sbjct: 768 VMFKDAVNRHYIYDTQGAAIAGSNLCTEIVHPASKRSSGVCNLGSVNLARCVS-----RQ 822
Query: 1711 YFDWDEYAYVIQKVAKYLDNSIDVNKFPLPEIDYNTKLTRRIGVGMMGLADALFKLGIPY 1770
FD+ +Q ++ ID P P+ R +G+GM GL A KLG+
Sbjct: 823 TFDFGRLRDAVQACVLMVNIMIDSTLQPTPQCTRGNDNLRSMGIGMQGLHTACLKLGLDL 882
Query: 1771 NSEEGFKFMRKVTEYLTFYAYKYSIEAAKKRGTFPL--YEKTGYPKGELPVEGFYHPEI- 1827
S E + + E + A K S A RG P ++++ Y G E F P+
Sbjct: 883 ESAEFQDLNKHIAEVMLLSAMKTS-NALCVRGARPFNHFKRSMYRAGRFHWERF--PDAR 939
Query: 1828 --WNLPWDKLVEEIKKYGVRNAMVTTCPPTGSVSMIADTSSGIEPIFALVYKKSVTVGEF 1885
+ W+ L + + K+G+RN+ PT + + I+D S G P+F ++ K GE
Sbjct: 940 PRYEGEWEMLRQSMMKHGLRNSQFVALMPTAASAQISDVSEGFAPLFTNLFSKVTRDGET 999
Query: 1886 YYVDPVFEAELKRRGLYSEELLKKISDNYGSVQ 1918
+ + EL+R +S + L ++ D+ + Q
Sbjct: 1000 LRPNTLLLKELER--TFSGKRLLEVMDSLDAKQ 1030
>gb|AAA45805.1| (M18410) ribonucleotide reductase 1 [human herpesvirus 1]
Length = 1137
Score = 82.7 bits (201), Expect = 4e-14
Identities = 73/273 (26%), Positives = 122/273 (43%), Gaps = 22/273 (8%)
Query: 1658 LVYDFTVPEHHMYISNGFM---SHNCGE--EPLYEYES--CNLASINLAKFVKYDENGKP 1710
+++ V H++Y + G S+ C E P + S CNL S+NLA+ V +
Sbjct: 768 VMFKDAVNRHYIYDTQGAAIAGSNLCTEIVHPASKRSSGVCNLGSVNLARCVS-----RQ 822
Query: 1711 YFDWDEYAYVIQKVAKYLDNSIDVNKFPLPEIDYNTKLTRRIGVGMMGLADALFKLGIPY 1770
FD+ +Q ++ ID P P+ R +G+GM GL A KLG+
Sbjct: 823 TFDFGRLRDAVQACVLMVNIMIDSTLQPTPQCTRGNDNLRSMGIGMQGLHTACLKLGLDL 882
Query: 1771 NSEEGFKFMRKVTEYLTFYAYKYSIEAAKKRGTFPL--YEKTGYPKGELPVEGFYHPEI- 1827
S E + + E + A K S A RG P ++++ Y G E F P+
Sbjct: 883 ESAEFQDLNKHIAEVMLLSAMKTS-NALCVRGARPFNHFKRSMYRAGRFHWERF--PDAR 939
Query: 1828 --WNLPWDKLVEEIKKYGVRNAMVTTCPPTGSVSMIADTSSGIEPIFALVYKKSVTVGEF 1885
+ W+ L + + K+G+RN+ PT + + I+D S G P+F ++ K GE
Sbjct: 940 PRYEGEWEMLRQSMMKHGLRNSQFVALMPTAASAQISDVSEGFAPLFTNLFSKVTRDGET 999
Query: 1886 YYVDPVFEAELKRRGLYSEELLKKISDNYGSVQ 1918
+ + EL+R +S + L ++ D+ + Q
Sbjct: 1000 LRPNTLLLKELER--TFSGKRLLEVMDSLDAKQ 1030
>emb|CAA30056.1| (X06999) ribonucleotide reductase [Escherichia coli]
Length = 761
Score = 81.9 bits (199), Expect = 7e-14
Identities = 59/213 (27%), Positives = 96/213 (44%), Gaps = 16/213 (7%)
Query: 1687 EYESCNLASINLAKFVKYDENGKPYFDWDEYAYVIQKVAKYLDNSIDVNKFPLPEIDYNT 1746
E C L++ NL DE +E A + + LD +D +P+P
Sbjct: 458 EIALCTLSAFNLGAINNLDE-------LEELAIL---AVRALDALLDYQDYPIPAAKRGA 507
Query: 1747 KLTRRIGVGMMGLADALFKLGIPYNSEEGFKFMRKVTEYLTFYAYKYSIEAAKKRGTFPL 1806
R +G+G++ A L G Y+ K E + +Y K S E AK++G P
Sbjct: 508 MGRRTLGIGVINFAYYLANDGKRYSDGSANNLTHKTFEAIQYYLLKASNELAKEQGACPW 567
Query: 1807 YEKTGYPKGELPVEGFYHP------EIWNLPWDKLVEEIKKYGVRNAMVTTCPPTGSVSM 1860
+ +T Y KG LP++ + E + W+ L E IK +G+RN+ ++ P+ + S
Sbjct: 568 FNETTYAKGILPIDTYKKDLDTIANEPLHYDWEALRESIKTHGLRNSTLSALMPSETSSQ 627
Query: 1861 IADTSSGIEPIFALVYKKSVTVGEFYYVDPVFE 1893
I++ ++GIEP V K+ G V P +E
Sbjct: 628 ISNATNGIEPPRGYVSIKASKDGILRQVVPDYE 660
>pir||B64135 ribonucleoside-diphosphate reductase (EC 1.17.4.1) alpha chain -
Haemophilus influenzae (strain Rd KW20)
>gi|1574509|gb|AAC23305.1| (U32839)
ribonucleoside-diphosphate reductase, alpha chain (nrdA)
[Haemophilus influenzae Rd]
Length = 781
Score = 81.5 bits (198), Expect = 9e-14
Identities = 56/213 (26%), Positives = 101/213 (47%), Gaps = 16/213 (7%)
Query: 1687 EYESCNLASINLAKFVKYDENGKPYFDWDEYAYVIQKVAKYLDNSIDVNKFPLPEIDYNT 1746
E C L++ NL K DE +E A + + LD +D +P+ ++
Sbjct: 483 EIALCTLSAFNLGKIENLDE-------LEELADL---AVRSLDALLDYQDYPVVAAKRSS 532
Query: 1747 KLTRRIGVGMMGLADALFKLGIPYNSEEGFKFMRKVTEYLTFYAYKYSIEAAKKRGTFPL 1806
R +G+G++ A L K G+ Y+ + E + +Y K S+ AK++G
Sbjct: 533 LARRSLGIGVINYAYYLAKNGVRYSDGSANDLTHRTFEAIQYYLLKASMNLAKEQGACEY 592
Query: 1807 YEKTGYPKGELPVEGF------YHPEIWNLPWDKLVEEIKKYGVRNAMVTTCPPTGSVSM 1860
+ +T Y KG LP++ + E + W+ L ++I+++G+RN+ +T P+ + S
Sbjct: 593 FNETTYAKGILPIDTYKKDLDSLTQEPLHYDWESLRKDIQEFGLRNSTLTALMPSETSSQ 652
Query: 1861 IADTSSGIEPIFALVYKKSVTVGEFYYVDPVFE 1893
I++ ++GIEP V K+ G V P +E
Sbjct: 653 ISNATNGIEPPRGHVSIKASKDGILKQVVPEYE 685
>sp|P43754|RIR1_HAEIN RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE ALPHA CHAIN (RIBONUCLEOTIDE
REDUCTASE)
Length = 756
Score = 81.5 bits (198), Expect = 9e-14
Identities = 56/213 (26%), Positives = 101/213 (47%), Gaps = 16/213 (7%)
Query: 1687 EYESCNLASINLAKFVKYDENGKPYFDWDEYAYVIQKVAKYLDNSIDVNKFPLPEIDYNT 1746
E C L++ NL K DE +E A + + LD +D +P+ ++
Sbjct: 458 EIALCTLSAFNLGKIENLDE-------LEELADL---AVRSLDALLDYQDYPVVAAKRSS 507
Query: 1747 KLTRRIGVGMMGLADALFKLGIPYNSEEGFKFMRKVTEYLTFYAYKYSIEAAKKRGTFPL 1806
R +G+G++ A L K G+ Y+ + E + +Y K S+ AK++G
Sbjct: 508 LARRSLGIGVINYAYYLAKNGVRYSDGSANDLTHRTFEAIQYYLLKASMNLAKEQGACEY 567
Query: 1807 YEKTGYPKGELPVEGF------YHPEIWNLPWDKLVEEIKKYGVRNAMVTTCPPTGSVSM 1860
+ +T Y KG LP++ + E + W+ L ++I+++G+RN+ +T P+ + S
Sbjct: 568 FNETTYAKGILPIDTYKKDLDSLTQEPLHYDWESLRKDIQEFGLRNSTLTALMPSETSSQ 627
Query: 1861 IADTSSGIEPIFALVYKKSVTVGEFYYVDPVFE 1893
I++ ++GIEP V K+ G V P +E
Sbjct: 628 ISNATNGIEPPRGHVSIKASKDGILKQVVPEYE 660
>sp|P39452|RIR3_ECOLI RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 2 ALPHA CHAIN (RIBONUCLEOTIDE
REDUCTASE 2) (R1E PROTEIN) >gi|7450628|pir||D65047
ribonucleoside-diphosphate reductase (EC 1.17.4.1) 2
alpha chain - Escherichia coli >gi|1789030|gb|AAC75722.1|
(AE000352) ribonucleoside-diphosphate reductase 2, alpha
subunit [Escherichia coli K12]
Length = 714
Score = 81.5 bits (198), Expect = 9e-14
Identities = 70/249 (28%), Positives = 112/249 (44%), Gaps = 36/249 (14%)
Query: 1690 SCNLASINLAKFVKYDENGKPYFDWDEYAYVIQKVAKYLDNSIDVNKF-PLPEIDYNTKL 1748
SCNL S+N+A + D ++A ++ + L D++ +P I+
Sbjct: 414 SCNLGSLNIAHTM----------DSPDFARTVETAVRGLTAVSDMSHIRSVPSIEAGNAA 463
Query: 1749 TRRIGVGMMGLADALFKLGIPYNSEEGFKFMRKVTEYLTFYAYKYSIEAAKKRG-TFPLY 1807
+ IG+G M L L + GI Y S E F +T++A + S+ A++RG TF +
Sbjct: 464 SHAIGLGQMNLHGYLAREGIAYGSPEALDFTNLYFYAITWHALRTSMLLARERGETFAGF 523
Query: 1808 EKTGYPKGEL---PVEGFYHPEIWN-----------LP----WDKLVEEIKKYGVRNAMV 1849
+++ Y GE ++G + P+ LP W +L +++ +YG+ N +
Sbjct: 524 KQSRYASGEYFSQYLQGNWQPKTAKVGELFTRSGITLPTREMWAQLRDDVMRYGIYNQNL 583
Query: 1850 TTCPPTGSVSMIADTSSGIEPIFALV-YKKSVTVGEFYYVDPVFEAELKRRGLYSEEL-- 1906
PPTGS+S I +S I PI A V +K G YY P E LY +
Sbjct: 584 QAVPPTGSISYINHATSSIHPIVAKVEIRKEGKTGRVYYPAPFMTNE--NLALYQDAYEI 641
Query: 1907 -LKKISDNY 1914
+KI D Y
Sbjct: 642 GAEKIIDTY 650
>gi|9629309 ribonucleotide reductase large subunit [human herpesvirus 2]
>gi|1869862|emb|CAB06725.1| (Z86099) ribonucleotide
reductase large subunit [human herpesvirus 2]
Length = 1142
Score = 80.0 bits (194), Expect = 3e-13
Identities = 67/251 (26%), Positives = 110/251 (43%), Gaps = 16/251 (6%)
Query: 1658 LVYDFTVPEHHMYISNGFM---SHNCGE--EPLYEYES--CNLASINLAKFVKYDENGKP 1710
+++ V H++Y + G S+ C E P + S CNL S+NLA+ V +
Sbjct: 773 IMFKDAVNRHYIYDTQGAAIAGSNLCTEIVHPASKRSSGVCNLGSVNLARCVS-----RQ 827
Query: 1711 YFDWDEYAYVIQKVAKYLDNSIDVNKFPLPEIDYNTKLTRRIGVGMMGLADALFKLGIPY 1770
FD+ +Q ++ ID P P+ R +G+GM GL A K+G+
Sbjct: 828 TFDFGRLRDAVQACVLMVNIMIDSTLQPTPQCTRGNDNLRSMGIGMQGLHTACLKMGLDL 887
Query: 1771 NSEEGFKFMRKVTEYLTFYAYKYSIEAAKKRGTFPL--YEKTGYPKGELPVEGFYHPEI- 1827
S E + E + A K S A RG P ++++ Y G E F +
Sbjct: 888 ESAEFRDLNTHIAEVMLLAAMKTS-NALCVRGARPFSHFKRSMYRAGRFHWERFSNASPR 946
Query: 1828 WNLPWDKLVEEIKKYGVRNAMVTTCPPTGSVSMIADTSSGIEPIFALVYKKSVTVGEFYY 1887
+ W+ L + + K+G+RN+ PT + + I+D S G P+F ++ K GE
Sbjct: 947 YEGEWEMLRQSMMKHGLRNSQFIALMPTAASAQISDVSEGFAPLFTNLFSKVTRDGETLR 1006
Query: 1888 VDPVFEAELKR 1898
+ + EL+R
Sbjct: 1007 PNTLLLKELER 1017
>gi|9632790 NDP reductase [Bacteriophage T4] >gi|417656|sp|P32282|RIR1_BPT4
RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE ALPHA CHAIN
(RIBONUCLEOTIDE REDUCTASE) (B1 PROTEIN)
>gi|509024|gb|AAA32527.1| (J03968) ribonucleoside
diphosphate reductase [Bacteriophage T4]
>gi|5354414|gb|AAD42621.1|AF158101_208 (AF158101) NDP
reductase [Bacteriophage T4]
Length = 754
Score = 79.2 bits (192), Expect = 5e-13
Identities = 61/213 (28%), Positives = 103/213 (47%), Gaps = 15/213 (7%)
Query: 1712 FDW---DEYAYVIQKVAKYLDNSIDVNKFPLPEIDYNTKLTRRIGVGMMGLADALFKLGI 1768
FDW D+ + + + LDN +D +P+PE + K R +GVG+ A L
Sbjct: 467 FDWQDQDKINELAEVQVRALDNLLDYQGYPVPEAE-KAKKRRNLGVGVTNYAAWLASNFA 525
Query: 1769 PYNSEEGFKFMRKVTEYLTFYAYKYSIEAAKKRGTFPLYEKTGYPKGELPVEGFYHPEI- 1827
Y E+ ++ E L + K SI+ AK++G Y T + +GELP++ +Y+ +I
Sbjct: 526 SY--EDANDLTHELFERLQYGLIKASIKLAKEKGPSEYYSDTRWSRGELPID-WYNKKID 582
Query: 1828 ------WNLPWDKLVEEIKKYGVRNAMVTTCPPTGSVSMIADTSSGIEPIFALVYKKSVT 1881
+ W L E++K +G+RN+ ++ P S S ++++++G EP V K
Sbjct: 583 QIAAPKYVCDWSALREDLKLFGIRNSTLSALMPCESSSQVSNSTNGYEPPRGPVSVKESK 642
Query: 1882 VGEFYYVDPVFEAELKRRGLYSEELLKKISDNY 1914
G F V P E + Y+ +L KK + Y
Sbjct: 643 EGSFNQVVPNIEHNIDLYD-YTWKLAKKGNKPY 674
>sp|P09853|RIR1_HSV23 RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE CHAIN (RIBONUCLEOTIDE
REDUCTASE) (136 KD SUBUNIT) >gi|330199|gb|AAA45806.1|
(M12700) ribonucleotide reductase large subunit (140K)
[human herpesvirus 1]
Length = 1144
Score = 77.3 bits (187), Expect = 2e-12
Identities = 67/251 (26%), Positives = 110/251 (43%), Gaps = 16/251 (6%)
Query: 1658 LVYDFTVPEHHMYISNGFM---SHNCGE--EPLYEYES--CNLASINLAKFVKYDENGKP 1710
+++ V H++Y + G S+ C E P + S CNL S+NLA+ V +
Sbjct: 775 IMFKDAVNRHYIYDTQGAAIAGSNLCTEIVHPSSKRSSGVCNLGSVNLARCVS-----RR 829
Query: 1711 YFDWDEYAYVIQKVAKYLDNSIDVNKFPLPEIDYNTKLTRRIGVGMMGLADALFKLGIPY 1770
FD+ +Q ++ ID P P+ R +G+GM GL A K+G+
Sbjct: 830 TFDFGMLRDAVQACVLMVNIMIDSTLQPTPQCARGHDNLRSMGIGMQGLHTACLKMGLDL 889
Query: 1771 NSEEGFKFMRKVTEYLTFYAYKYSIEAAKKRGTFPL--YEKTGYPKGELPVEGFYHPEI- 1827
S E + E + A K S A RG P ++++ Y G E F +
Sbjct: 890 ESAEFRDLNTHIAEVMLLAAMKTS-NALCVRGARPFSHFKRSMYRAGRFHWERFSNASPR 948
Query: 1828 WNLPWDKLVEEIKKYGVRNAMVTTCPPTGSVSMIADTSSGIEPIFALVYKKSVTVGEFYY 1887
+ W+ L + + K+G+RN+ PT + + I+D S G P+F ++ K GE
Sbjct: 949 YEGEWEMLRQSMMKHGLRNSQFIALMPTAASAQISDVSEGFAPLFTNLFSKVTRDGETLR 1008
Query: 1888 VDPVFEAELKR 1898
+ + EL+R
Sbjct: 1009 PNTLLLKELER 1019
>sp|P50640|RIR1_MYCTU RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE ALPHA CHAIN (RIBONUCLEOTIDE
REDUCTASE R1 SUBUNIT) >gi|7450629|pir||F70861 probable
nrdE protein - Mycobacterium tuberculosis (strain H37RV)
>gi|3261509|emb|CAA16136.1| (AL021287) nrdE
[Mycobacterium tuberculosis]
Length = 693
Score = 77.3 bits (187), Expect = 2e-12
Identities = 64/224 (28%), Positives = 100/224 (44%), Gaps = 35/224 (15%)
Query: 1690 SCNLASINLAKFVKYDENGKPYFDWDEYAYVIQKVAKYLDNSIDVNKFP-LPEIDYNTKL 1748
SCNL S+N+AK + D ++A I+ + L D +P I+
Sbjct: 393 SCNLGSLNIAKTM----------DSPDFAQTIEVAIRALTAVSDQTHIKSVPSIEQGNND 442
Query: 1749 TRRIGVGMMGLADALFKLGIPYNSEEGFKFMRKVTEYLTFYAYKYSIEAAKKRGT-FPLY 1807
+ IG+G M L L + I Y S+EG F + ++A + S A +RGT F +
Sbjct: 443 SHAIGLGQMNLHGYLARERIFYGSDEGIDFTNIYFYTVLYHALRASNRIAIERGTHFKGF 502
Query: 1808 EKTGYPKGELPVEGFYHPEIWN----------------LP----WDKLVEEIKKYGVRNA 1847
E++ Y GE + Y +IW +P W +L E ++ +G+ N
Sbjct: 503 ERSKYASGEFFDK--YTDQIWEPKTQKVRQLFADAGIRIPTQDDWRRLKESVQAHGIYNQ 560
Query: 1848 MVTTCPPTGSVSMIADTSSGIEPIFALV-YKKSVTVGEFYYVDP 1890
+ PPTGS+S I ++S I PI + V +K +G YY P
Sbjct: 561 NLQAVPPTGSISYINHSTSSIHPIVSKVEIRKEGKIGRVYYPAP 604
>gi|10140905 UL39 product homolog [Gallid herpesvirus 1 (serotype 2)]
>gi|10834910|ref|NP_066871.1| UL39 protein [Gallid
herpesvirus 3] >gi|5102911|dbj|BAA78728.1| (AB024309)
UL39 protein [Gallid herpesvirus 1 (serotype 2)]
>gi|5689311|dbj|BAA82935.1| (AB024414) UL39 product
homolog [Gallid herpesvirus 1 (serotype 2)]
>gi|10800004|dbj|BAB16549.1| (AB049735) UL39 protein
[Gallid herpesvirus 3]
Length = 797
Score = 77.3 bits (187), Expect = 2e-12
Identities = 51/210 (24%), Positives = 99/210 (46%), Gaps = 5/210 (2%)
Query: 1691 CNLASINLAKFVKYDENGKPYFDWDEYAYVIQKVAKYLDNSIDVNKFPLPEIDYNTKLTR 1750
C+L S+NLA+ V +DENG+ FD+ ++ ++++ + + P + R
Sbjct: 462 CSLVSVNLARCV-FDENGEKKFDFSALRRAVRLATVFVNSIMSSSDVPTAKSRSGKDRHR 520
Query: 1751 RIGVGMMGLADALFKLGIPYNSEEGFKFMRKVTEYLTFYAYKYSIEAAKKR-GTFPLYEK 1809
+G+G+ GL AL +G+ + E +++ E + A S E + F +
Sbjct: 521 SMGIGVQGLHTALLSMGLDLSDERVKPLNKQIFELMLLEAMTVSCEFCEGGLPAFADFSN 580
Query: 1810 TGYPKGELPVEGFYHPEIWNLP--WDKLVEEIKKYGVRNAMVTTCPPTGSVSMIADTSSG 1867
+ Y +G L +G+ + + ++P W+ L E I+ G+ NA PT + + + + S
Sbjct: 581 SYYSRGRLHFDGWANVGL-SMPEEWNALRERIQASGLYNAQFVALMPTAASAQVTEVSES 639
Query: 1868 IEPIFALVYKKSVTVGEFYYVDPVFEAELK 1897
P+F+ ++ K T GE + EL+
Sbjct: 640 FLPVFSNMFNKVTTAGELLRPNNQLMGELR 669
>pir||G71213 probable H(+)-transporting ATP synthase subunit A - Pyrococcus
horikoshii >gi|3258419|dbj|BAA31102.1| (AP000007) 964aa
long hypothetical H(+)-transporting ATP synthase subunit
A [Pyrococcus horikoshii]
Length = 964
Score = 76.9 bits (186), Expect = 2e-12
Identities = 90/320 (28%), Positives = 141/320 (43%), Gaps = 55/320 (17%)
Query: 714 IVGTTTGAACFTGDTRILTEK-GLIPIEEIVHET-GKKPKVV-------------THAGL 758
I G C GDT +LT++ GLI I+E+ + GK K+V T G
Sbjct: 232 IPGPFGSGKCVDGDTLVLTKEFGLIKIKELYEKLDGKGRKIVEGNEEWTELEKPITVYGY 291
Query: 759 KD--IIE-----TYDNGEMEVFRVTTEDGYELKVTGDHKFLVFDENGNPTLKPLKEL--- 808
KD I+E Y + + T G ++KVT H+ + + LKE+
Sbjct: 292 KDGKIVEIKATHVYKGVSSGMVEIRTRTGRKIKVTPIHRLFTGRVTKDGLI--LKEVMAM 349
Query: 809 --KVGDYVYILAPEWKGGEYVELDTNIELKGKGYNVNLPSKLDEKLAYLLGIIYADGHIR 866
K GD + ++ + GGEY++LD++ + +P L+E+LA LG + A
Sbjct: 350 HVKPGDRIAVVK-KIDGGEYIKLDSS-----NVGEIKVPEILNEELAEFLGYLMA----- 398
Query: 867 HYFENGKRKNSKIEIYLHQDETEIKEKVKRYFKEIFGIEPKEFLKEEQHKVILVIPSTKI 926
NG K+ IEIY D+ + E+V ++FG+ + K + LVI S +
Sbjct: 399 ----NGTLKSGIIEIYC--DDESLLERVNSLSLKLFGVGGRIVQKVDGKA--LVIQSKPL 450
Query: 927 VKFLEINGLLKDKS-ENIRVPEAIFRSRPSVIAAFLAGFFDGDGSIDQNYRIAFKSISRE 985
V L G+ +DK EN +VP + S +V+ AF+ + G ++ S E
Sbjct: 451 VDVLRRLGVPEDKKVENWKVPRELLLSPSNVVRAFVNAYIKGKEEVE------ITLASEE 504
Query: 986 FIKEAQLLFLALGIVTSIQE 1005
E LF LGI +I +
Sbjct: 505 GAYELSYLFAKLGIYVTISK 524
>emb|CAC18555.1| (AJ245819) DNA polymerase and endonucleases [Thermococcus
hydrothermalis]
Length = 1668
Score = 76.5 bits (185), Expect = 3e-12
Identities = 108/428 (25%), Positives = 168/428 (39%), Gaps = 87/428 (20%)
Query: 1299 VVGETRILTPEG----YIKAEELFKLAKER-GKMEAIAVEGIAEGGEPYAYSLEILLPGD 1353
V GET I+ ++ EELF+ R G+ E +EG+ + L
Sbjct: 1046 VTGETEIIIKRNGKVEFVAIEELFQRVDYRIGEKEYCVLEGVEA----------LTLDNR 1095
Query: 1354 KQVKYETVHGNAVEVADPVSVPAYVWKVGMKEVARVRTKEGYEITATLDHKLMTPEGWKE 1413
++ ++ SVP + K + RV + + T DH L+ +
Sbjct: 1096 GRLVWK-------------SVPYVMRHRTNKRIYRVWFTNSWYLDVTEDHSLIGYMNTSK 1142
Query: 1414 IK----------DLKPGD------KILLPRFEVEEDFGSESIGEDLAFVLGWFIGDGYLN 1457
+K ++KPG+ ++ P + I L ++G +GDG N
Sbjct: 1143 VKPGKPLKERLVEVKPGELGESVKSLITPNRAIAHGIRVNPIAVKLWELIGLLVGDG--N 1200
Query: 1458 VKDKRAWFYFNA------EKEEEIAWKIREILAKRFEIKAEPHRYGNQIKLGVRGKAYEW 1511
+ W +N +KEE I E + K + Y ++ K G +W
Sbjct: 1201 WGGQSNWAKYNVGLSLGLDKEE-----IEEKILKPLKNTGIISNYYDKSKKGDVSILSKW 1255
Query: 1512 LESIV------KTNEKRIPEIVYRLKPNEIASFLRGLFSADGYVD---NDMAIRLTSKSR 1562
L + ++ KRIPE ++ L I +FLRGLFSADG V +RLTS +
Sbjct: 1256 LARFMVRYFKDESGSKRIPEFMFNLPREYIEAFLRGLFSADGTVSLRKGVPEVRLTSVNP 1315
Query: 1563 ELLREVQDLLLLFGILSKIYERPYKREFKYTTKDGEERTYTTEGYYELVIANYSRKIFAE 1622
EL V+ LL L G+ + ++ +Y K+ G + + + + FAE
Sbjct: 1316 ELSSSVRKLLWLVGVSNSMFVETNPN--RYLGKE--------SGTHSVHVRIKDKHRFAE 1365
Query: 1623 RIG-LEGYKMEKLS---------LEKIKVDEPIVTVESV-EILGKKLVYDFTVPEHHMYI 1671
RIG L K KLS K D +V + V EI VYD V H +
Sbjct: 1366 RIGFLLDRKATKLSENLGGHTSKKRAYKYDFDLVYPKKVEEIAYDGYVYDIEVEGTHRFF 1425
Query: 1672 SNGFMSHN 1679
+NG + HN
Sbjct: 1426 ANGILVHN 1433
>pir||F71231 probable replication factor C subunit - Pyrococcus horikoshii
>gi|3256498|dbj|BAA29181.1| (AP000001) 855aa long
hypothetical replication factor C subunit [Pyrococcus
horikoshii]
Length = 855
Score = 75.7 bits (183), Expect = 5e-12
Identities = 79/275 (28%), Positives = 124/275 (44%), Gaps = 45/275 (16%)
Query: 1377 YVWKVGMKEVARVRTKEGYEITATLDHKLMTPEG-----WKEIKDLKPGDKILLPRFEVE 1431
YV+K + + R+RT+ G E+ T H L+ W + ++LKPGDK+ +PRF
Sbjct: 116 YVYKDKTERLIRIRTRLGRELKVTPYHPLLVNRRNGEIKWVKAEELKPGDKLAVPRFL-- 173
Query: 1432 EDFGSESIGED-LAFVLGWFIGDGYLNVKDKRAWFYFNAEKEEEIAWKIREILAKRFEIK 1490
GED LA LG+F+G GY + K+ F + ++ E L I+
Sbjct: 174 ----PIVTGEDPLAEWLGYFLGGGYADSKENLIMFTNEDPLLRQRFMELTEKLFSDARIR 229
Query: 1491 AEPHRYGNQIKLGVRGKAYEWLESIVKTNEKRIPEIVYRLKPNEIASFLRGLFSADGYVD 1550
H G K+ V K + L+ + IP+ +R I SFLR F +G V
Sbjct: 230 EITHENGTS-KVYVNSK--KALKLVNSLGNAHIPKECWR----GIRSFLRAYFDCNGGVK 282
Query: 1551 NDMAIRLTSKSRELLREVQDLLLLFGILSKIYERPYKREFKYTTKDGEERTYTTEGYYEL 1610
+ AI L + S+E+ +E+ L FGI+S+I E Y +
Sbjct: 283 GN-AIVLATASKEMSQEIAYALAGFGIISRIQE-----------------------YRVI 318
Query: 1611 VIANYSRKIFAERIG-LEGYKMEKLSLEKIKVDEP 1644
+ + + K F IG + K+EK +L+ +K D+P
Sbjct: 319 ISGSDNVKKFLNEIGFINRNKLEK-ALKLVKKDDP 352
>sp|P30317|DPOL_THELI DNA POLYMERASE (VENT DNA POLYMERASE) [CONTAINS: PI-TLI I
ENDONUCLEASE; PI-TLI II ENDONUCLEASE]
>gi|543522|pir||S42459 DNA-directed DNA polymerase (EC
2.7.7.7) Vent, intein containing precursor - Thermococcus
litoralis >gi|154686|gb|AAA72100.1| (M74198)
DNA-dependent DNA polymerase precursor [Thermococcus
litoralis]
Length = 1702
Score = 74.5 bits (180), Expect = 1e-11
Identities = 92/333 (27%), Positives = 141/333 (41%), Gaps = 48/333 (14%)
Query: 1384 KEVARVRTKEGYEITATLDHKLM-------------TPEGWKEIKDLKPGDKI---LLPR 1427
K + R+ + I T DH L+ E KE+K + G + + P
Sbjct: 1150 KRMFRIWLTNSWYIDVTEDHSLIGYLNTSKTKTAKKIGERLKEVKPFELGKAVKSLICPN 1209
Query: 1428 FEV-EEDFGSESIGEDLAFVLGWFIGDGYLNVKDKRAWFYFN---AEKEEEIAWKIREIL 1483
+ +E+ + I ++G +GDG + A +Y + EEI K+ E L
Sbjct: 1210 APLKDENTKTSEIAVKFWELVGLIVGDGNWGGDSRWAEYYLGLSTGKDAEEIKQKLLEPL 1269
Query: 1484 AKRFEIKAEPHRYGNQIKLGVRGKAY-EWLESIVKTNE--KRIPEIVYRLKPNEIASFLR 1540
K + + + + + + K+ ++++ K + ++IPE +Y L I +FLR
Sbjct: 1270 -KTYGVISNYYPKNEKGDFNILAKSLVKFMKRHFKDEKGRRKIPEFMYELPVTYIEAFLR 1328
Query: 1541 GLFSADGYV---DNDMAIRLTSKSRELLREVQDLLLLFGILSKIYERPYKREFKYTTKDG 1597
GLFSADG V IRLT+ + LREV+ LL + GI + I F TT +
Sbjct: 1329 GLFSADGTVTIRKGVPEIRLTNIDADFLREVRKLLWIVGISNSI--------FAETTPNR 1380
Query: 1598 EERTYTTEGYYELVIANYSRKIFAERIG----------LEGYKMEKLSLEKIKVDEPIVT 1647
T L I N R FAERIG LE K ++ I +V
Sbjct: 1381 YNGVSTGTYSKHLRIKNKWR--FAERIGFLIERKQKRLLEHLKSARVKRNTIDFGFDLVH 1438
Query: 1648 VESV-EILGKKLVYDFTVPEHHMYISNGFMSHN 1679
V+ V EI + VYD V E H + +N + HN
Sbjct: 1439 VKKVEEIPYEGYVYDIEVEETHRFFANNILVHN 1471
>pir||S34271 ribonucleoside-diphosphate reductase (EC 1.17.4.1) - Salmonella
typhimurium
Length = 705
Score = 74.5 bits (180), Expect = 1e-11
Identities = 62/229 (27%), Positives = 98/229 (42%), Gaps = 35/229 (15%)
Query: 1690 SCNLASINLAKFVKYDENGKPYFDWDEYAYVIQKVAKYLDNSIDVNKF-PLPEIDYNTKL 1748
SCNL S+N+A + + G+ ++ + L D++ +P I
Sbjct: 405 SCNLGSLNIAHVMDSPDIGR----------TVETAIRGLTAVSDMSHIRSVPSIAAGNAA 454
Query: 1749 TRRIGVGMMGLADALFKLGIPYNSEEGFKFMRKVTEYLTFYAYKYSIEAAKKRG-TFPLY 1807
+ IG+G M L L + GI Y S E F +T++A S+ A++RG TF +
Sbjct: 455 SHAIGLGQMNLHGYLAREGIAYGSPEALDFTNLYFYTITWHAVHTSMRLARERGKTFAGF 514
Query: 1808 EKTGYPKGELPVEGFYHPEIWN----------------LP----WDKLVEEIKKYGVRNA 1847
++ Y G+ + Y + W LP W KL +++ +YG+ N
Sbjct: 515 AQSRYASGDYFTQ--YLQDDWQPKTAKVRALFARSGITLPTREMWLKLRDDVMRYGIYNQ 572
Query: 1848 MVTTCPPTGSVSMIADTSSGIEPIFALV-YKKSVTVGEFYYVDPVFEAE 1895
+ PPTGS+S I +S I PI A + +K G YY P E
Sbjct: 573 NLQAVPPTGSISYINHATSSIHPIVAKIEIRKEGKTGRVYYPAPFMTNE 621
>sp|Q08698|RIR3_SALTY RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 2 ALPHA CHAIN (RIBONUCLEOTIDE
REDUCTASE 2) (R1E PROTEIN) >gi|1184247|emb|CAA51699.1|
(X73226) ribonucleoside-diphosphate reductase [Salmonella
typhimurium]
Length = 714
Score = 74.5 bits (180), Expect = 1e-11
Identities = 62/229 (27%), Positives = 98/229 (42%), Gaps = 35/229 (15%)
Query: 1690 SCNLASINLAKFVKYDENGKPYFDWDEYAYVIQKVAKYLDNSIDVNKF-PLPEIDYNTKL 1748
SCNL S+N+A + + G+ ++ + L D++ +P I
Sbjct: 414 SCNLGSLNIAHVMDSPDIGR----------TVETAIRGLTAVSDMSHIRSVPSIAAGNAA 463
Query: 1749 TRRIGVGMMGLADALFKLGIPYNSEEGFKFMRKVTEYLTFYAYKYSIEAAKKRG-TFPLY 1807
+ IG+G M L L + GI Y S E F +T++A S+ A++RG TF +
Sbjct: 464 SHAIGLGQMNLHGYLAREGIAYGSPEALDFTNLYFYTITWHAVHTSMRLARERGKTFAGF 523
Query: 1808 EKTGYPKGELPVEGFYHPEIWN----------------LP----WDKLVEEIKKYGVRNA 1847
++ Y G+ + Y + W LP W KL +++ +YG+ N
Sbjct: 524 AQSRYASGDYFTQ--YLQDDWQPKTAKVRALFARSGITLPTREMWLKLRDDVMRYGIYNQ 581
Query: 1848 MVTTCPPTGSVSMIADTSSGIEPIFALV-YKKSVTVGEFYYVDPVFEAE 1895
+ PPTGS+S I +S I PI A + +K G YY P E
Sbjct: 582 NLQAVPPTGSISYINHATSSIHPIVAKIEIRKEGKTGRVYYPAPFMTNE 630
>sp|Q55418|DNAB_SYNY3 REPLICATIVE DNA HELICASE >gi|7470824|pir||S75781 replicative DNA
helicase (EC 3.6.1.-) dnaB - Synechocystis sp. (strain
PCC 6803) >gi|1001271|dbj|BAA10516.1| (D64003)
replicative DNA helicase [Synechocystis sp.]
Length = 872
Score = 74.1 bits (179), Expect = 2e-11
Identities = 71/282 (25%), Positives = 129/282 (45%), Gaps = 36/282 (12%)
Query: 1378 VWKVGMKEVARVRTKEGYEITATLDHKLMTPEGWKEIKDLKPGDKILLPRFEVEEDFGSE 1437
V+ G K V ++T+ G I AT +H+ +T +GWK + +L + I LPR E +
Sbjct: 428 VFCTGKKLVYILKTRLGRTIKATANHRFLTIDGWKRLDELSLKEHIALPR--KLESSSLQ 485
Query: 1438 SIGEDLAFVLGWFIGDGYLNVKDKRAWFYFNAEKEEEIAWKIREILAKRFEIKAEPHRYG 1497
+ ++ +LG IGDG + + E E++ + + + + R
Sbjct: 486 LMSDEELGLLGHLIGDGCTLPRHAIQYTSNKIELAEKVVELAKAVFGDQINPRISQERQW 545
Query: 1498 NQIKL--------GVRGKAYEWLESI----VKTNEKRIPEIVYRLKPNEIASFLRGLFSA 1545
Q+ + + +WLE++ +++ EK +P V+ IA FLR L+S
Sbjct: 546 YQVYIPASYRLTHNKKNPITKWLENLDVFGLRSYEKFVPNQVFEQPQRAIAIFLRHLWST 605
Query: 1546 DGYV-------DNDMAIRLTSKSRELLREVQDLLLLFGILSKIYERPYKREFKYTTKDGE 1598
DG V +A TS S +L ++VQ LLL GI +++ + +++G+
Sbjct: 606 DGCVKLIVEKSSRPVAYYATS-SEKLAKDVQSLLLKLGINARLSK---------ISQNGK 655
Query: 1599 ERTYTTEGYYELVIANYSRKIFAERIGLEGYKMEKLSLEKIK 1640
R + Y+ + +IF ++IG K ++ S+E+IK
Sbjct: 656 GR----DNYHVTITGQADLQIFVDQIGAVD-KDKQASVEEIK 692
>gb|AAG30079.1|AF282130_42 (AF282130) UL39 ribonucleotide reductase large subunit [Meleagrid
herpesvirus 1]
Length = 820
Score = 74.1 bits (179), Expect = 2e-11
Identities = 56/224 (25%), Positives = 100/224 (44%), Gaps = 7/224 (3%)
Query: 1691 CNLASINLAKFVKYDENGKPYFDWDEYAYVIQKVAKYLDNSIDVNKFPLPEIDYNTKLTR 1750
C LASINLA+ V+ NG+ FD+D + ++ + + +D + P + R
Sbjct: 485 CTLASINLARCVRR-VNGECKFDFDALRHAVRLATVFTNAIMDGSDVPTVKSQSGRDRNR 543
Query: 1751 RIGVGMMGLADALFKLGIPYNSEEGFKFMRKVTEYLTFYAYKYSIEAAKKR-GTFPLYEK 1809
IG+G+ G A+ LG+ +++ E + A S E ++ FP +
Sbjct: 544 SIGIGVQGFHTAMLSLGLDLEDGAVRALNKQIFELMLLEAMTVSCEFCERGLPPFPDFSD 603
Query: 1810 TGYPKGELPVEGFYHPEIWNLP--WDKLVEEIKKYGVRNAMVTTCPPTGSVSMIADTSSG 1867
+ Y +G L +G+ E+ P W L I G+ NA PT + + + + S G
Sbjct: 604 SYYAQGRLHFDGWDSVEL-TAPEEWGVLRGRIMSSGLYNAQFIALMPTAASAQVTEVSEG 662
Query: 1868 IEPIFALVYKKSVTVGEFYYVDPVFEAELKRRGLYSEELLKKIS 1911
P+F+ ++ K + GE + EL R +Y + +++S
Sbjct: 663 FAPLFSNMFSKVTSAGELLRPNSQLMREL--RQIYPDNEQRRLS 704
>emb|CAC17731.1| (AJ251716) GyrA protein [Mycobacterium gastri]
Length = 550
Score = 74.1 bits (179), Expect = 2e-11
Identities = 90/387 (23%), Positives = 155/387 (39%), Gaps = 70/387 (18%)
Query: 1268 ADPGVIFFDIINRRNVLKEAKGGPIRATNPCVVGETRILTPEGYIKAEELFKLAKERGKM 1327
A P + + +++ + P A C G+T + P G
Sbjct: 34 AQPWSLRYPLVDGQGNFGSPGNDPPAAMRYCTTGDTLVRLPFG----------------- 76
Query: 1328 EAIAVEGIAEGGEPYAYSLEILLPGDKQVKYETVHGNAVEVADPVSVPAYVWKVGMKEVA 1387
+++ + + G P + + L D+ HGN V VAD +++ G +
Sbjct: 77 QSMRIADVVPGASPNSDNAVELKVLDR-------HGNPV-VAD------HLFHSGDHQTY 122
Query: 1388 RVRTKEGYEITATLDHKLMTPEG--------WKEIKDLKPGDKILLPRFEVEEDFGSESI 1439
VRT EGYE+T T +H L+ WK I ++ D + L R E ++
Sbjct: 123 TVRTAEGYEVTGTANHPLLCLVDVGGVPTLLWKLIGEIHANDYVALQRTPPMELGPADWH 182
Query: 1440 GEDLAFVLGWFIGDGYLN------VKDKRAWFYFNAEKEEEIAWKIREILAKRFEIKAEP 1493
G A +LG FI +GY++ R +F A + + R + + +
Sbjct: 183 GTMEALLLGAFISEGYVSETRTGFANLDRDYFTTAAGAYDGVVGGKRYVYQQTIGSGSPQ 242
Query: 1494 HRYGNQIKLGVRGKAYEWLESIVKTNEKRIPEIVYRLKPNEIASFLRGLFSADGYVD--- 1550
H Q K+ ++ W V++ +K +PE ++ +FLR LF G
Sbjct: 243 HTLYTQ-KVTALKQSRLWQMVGVRSADKYVPEWMWHSPAAVKRTFLRALFEGGGSCSRLP 301
Query: 1551 -NDMAIRLTSKSRELLREVQDLLLLFGILSKIYERPYKREFKYTTKDGEERTYTTEGYYE 1609
+ I T+ S++L +VQ +LL FG++S+ Y G Y+
Sbjct: 302 RKTIQISYTTISKQLAMDVQQMLLEFGVISRRY-------------------LHAVGEYK 342
Query: 1610 LVIANYSR-KIFAERIGLEGYKMEKLS 1635
+VI N ++ ++FA +IG G K KL+
Sbjct: 343 VVITNRAQAELFATQIGFGGAKQTKLT 369
>gb|AAA64444.1| (L34407) ribonucleotide reductase R1 subunit [Mycobacterium
tuberculosis]
Length = 723
Score = 74.1 bits (179), Expect = 2e-11
Identities = 63/224 (28%), Positives = 99/224 (44%), Gaps = 35/224 (15%)
Query: 1690 SCNLASINLAKFVKYDENGKPYFDWDEYAYVIQKVAKYLDNSIDVNKFP-LPEIDYNTKL 1748
SCNL S+N+AK + D ++A I+ + L +P I+
Sbjct: 423 SCNLGSLNIAKTM----------DSPDFAQTIEVAIRALTAVRHQTHIKSVPSIEQGNND 472
Query: 1749 TRRIGVGMMGLADALFKLGIPYNSEEGFKFMRKVTEYLTFYAYKYSIEAAKKRGT-FPLY 1807
+ IG+G M L L + I Y S+EG F + ++A + S A +RGT F +
Sbjct: 473 SHAIGLGQMNLHGYLARERIFYGSDEGIDFTNIYFYTVLYHALRASNRIAIERGTHFKGF 532
Query: 1808 EKTGYPKGELPVEGFYHPEIWN----------------LP----WDKLVEEIKKYGVRNA 1847
E++ Y GE + Y +IW +P W +L E ++ +G+ N
Sbjct: 533 ERSKYASGEFFDK--YTDQIWEPKTQKVRQLFADAGIRIPTQDDWRRLKESVQAHGIYNQ 590
Query: 1848 MVTTCPPTGSVSMIADTSSGIEPIFALV-YKKSVTVGEFYYVDP 1890
+ PPTGS+S I ++S I PI + V +K +G YY P
Sbjct: 591 NLQAVPPTGSISYINHSTSSIHPIVSKVEVRKEGKIGRVYYPAP 634
Database: ./suso.pep
Posted date: Jul 6, 2001 5:57 PM
Number of letters in database: 840,471
Number of sequences in database: 2977
Database: /banques/blast2/nr.pep
Posted date: Dec 14, 2000 12:46 PM
Number of letters in database: 188,266,275
Number of sequences in database: 595,510
Lambda K H
0.318 0.139 0.403
Gapped
Lambda K H
0.270 0.0470 0.230
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 828200193
Number of Sequences: 2977
Number of extensions: 38743617
Number of successful extensions: 105114
Number of sequences better than 1.0e-10: 134
Number of HSP's better than 0.0 without gapping: 53
Number of HSP's successfully gapped in prelim test: 81
Number of HSP's that attempted gapping in prelim test: 104184
Number of HSP's gapped (non-prelim): 629
length of query: 2122
length of database: 189,106,746
effective HSP length: 60
effective length of query: 2062
effective length of database: 153,197,526
effective search space: 315893298612
effective search space used: 315893298612
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 41 (21.7 bits)
S2: 173 (71.8 bits)