BLASTP 2.0.10 [Aug-26-1999]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= PAB1083 (purM) DE:phosphoribosylformylglycinamidine
cyclo-ligase (purM)
(334 letters)
Database: ./suso.pep; /banques/blast2/nr.pep
598,487 sequences; 189,106,746 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
pir||F75014 phosphoribosylformylglycinamidine cyclo-ligase (purm... 669 0.0
pir||F71457 probable phosphoribosylformylglycinamide cyclo-ligas... 581 e-165
sp|O27272|PUR5_METTH PROBABLE PHOSPHORIBOSYLFORMYLGLYCINAMIDINE ... 300 2e-80
sp|Q57656|PUR5_METJA PROBABLE PHOSPHORIBOSYLFORMYLGLYCINAMIDINE ... 294 1e-78
gi|11499283 phosphoribosylformylglycinamidine cyclo-ligase (purM... 289 2e-77
emb|CAB57665.1| (Y18930) phosphoribosylformylglycinamidine cyclo... 268 8e-71
gb|AAK40944.1| Phosphoribosylformylglycinamidine cyclo-ligase (A... 268 8e-71
emb|CAC11238.1| (AL445063) probable phosphoribosyl-aminoimidazol... 261 1e-68
gb|AAG19319.1| (AE005027) phosphoribosylformylglycinamidine cycl... 255 5e-67
sp|P12043|PUR5_BACSU PHOSPHORIBOSYLFORMYLGLYCINAMIDINE CYCLO-LIG... 235 5e-61
pir||E70367 phosphoribosylformylglycinamidine cyclo-ligase (EC 6... 230 2e-59
dbj|BAA89440.1| (AB003158) 5'-phosphoribosyl-5-aminoimidazole sy... 224 2e-57
dbj|BAB04350.1| (AP001509) phosphoribosylaminoimidazole syntheta... 221 8e-57
pir||F81911 probable phosphoribosylformylglycinamidine cyclo-lig... 215 7e-55
pir||E81104 phosphoribosylformylglycinamidine cyclo-ligase NMB12... 214 1e-54
pir||A70809 probable 5'-phosphoribosyl-5-aminoimidazole syntheta... 213 2e-54
sp|Q99148|PUR2_YARLI BIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN AD... 212 4e-54
sp|P52424|PUR5_VIGUN PHOSPHORIBOSYLFORMYLGLYCINAMIDINE CYCLO-LIG... 211 1e-53
pir||S75786 phosphoribosylformylglycinamidine cyclo-ligase (EC 6... 209 4e-53
sp|P43848|PUR5_HAEIN PHOSPHORIBOSYLFORMYLGLYCINAMIDINE CYCLO-LIG... 207 1e-52
pir||T47640 phosphoribosylformylglycinamidine cyclo-ligase precu... 205 5e-52
sp|P20772|PUR2_SCHPO BIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN AD... 205 8e-52
pir||A83529 phosphoribosylaminoimidazole synthetase PA0945 [impo... 205 8e-52
pir||F82103 phosphoribosylformylglycinamidine cyclo-ligase VC222... 204 1e-51
gb|AAC16901.1| (AF016634) phosphoribosylformylglycinamide cyclo-... 203 2e-51
gb|AAG14579.1|AF293165_1 (AF293165) phosphoribosylaminoimidazole... 202 4e-51
gi|4503915 phosphoribosylglycinamide formyltransferase, phosphor... 202 6e-51
gb|AAB08890.1| (U68765) 5'-phosphoribosyl-5-aminoimidazole synth... 201 7e-51
gb|AAD00110.1| (U64826) phosphoribosyl aminoimidazole synthetase... 201 7e-51
gb|AAG14633.1|AF293192_1 (AF293192) phosphoribosylaminoimidazole... 201 1e-50
gb|AAG14663.1|AF293207_1 (AF293207) phosphoribosylaminoimidazole... 201 1e-50
gb|AAG14569.1|AF293160_1 (AF293160) phosphoribosylaminoimidazole... 201 1e-50
gb|AAG14585.1|AF293168_1 (AF293168) phosphoribosylaminoimidazole... 201 1e-50
sp|P08178|PUR5_ECOLI PHOSPHORIBOSYLFORMYLGLYCINAMIDINE CYCLO-LIG... 200 2e-50
pdb|1CLI|A Chain A, X-Ray Crystal Structure Of Aminoimidazole Ri... 200 2e-50
gb|AAG14583.1|AF293167_1 (AF293167) phosphoribosylaminoimidazole... 200 2e-50
sp|P21872|PUR2_CHICK TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN A... 199 3e-50
gb|AAG14577.1|AF293164_1 (AF293164) phosphoribosylaminoimidazole... 199 4e-50
gb|AAG10596.1|AF293159_1 (AF293159) phosphoribosylaminoimidazole... 198 6e-50
gb|AAG14655.1|AF293203_1 (AF293203) phosphoribosylaminoimidazole... 198 6e-50
gb|AAG09178.1| (AF174494) purine biosynthetic pathway protein AD... 198 8e-50
gb|AAG14581.1|AF293166_1 (AF293166) phosphoribosylaminoimidazole... 198 8e-50
emb|CAB46525.1| (AJ243305) 5'-phosphoribosyl-5-aminoimidazole sy... 196 2e-49
pir||E82789 5'-phosphoribosyl-5-aminoimidazole synthetase XF0587... 196 4e-49
gi|6857793 phosphoribosylglycinamide formyltransferase [Mus musc... 191 8e-48
pir||I67805 purine synthesis multifunctional protein - mouse >gi... 190 2e-47
gi|6321203 glycinamide ribotide synthetase and aminoimidazole ri... 190 2e-47
pir||G81299 phosphoribosylformylglycinamidine cyclo-ligase (EC 6... 187 2e-46
sp|Q26255|PUR2_CHITE TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN A... 182 4e-45
sp|Q05728|PUR5_ARATH PHOSPHORIBOSYLFORMYLGLYCINAMIDINE CYCLO-LIG... 182 5e-45
gb|AAF71749.1| (AF257743) phosphoribosylglycinamide formyltransf... 179 5e-44
gb|AAC96120.1| (AF083221) glycinamide ribonucleotide transformyl... 176 2e-43
pir||B75400 phosphoribosylformylglycinamidine cyclo-ligase - Dei... 169 3e-41
pir||E72277 phosphoribosylformylglycinamidine cyclo-ligase - The... 161 9e-39
gb|AAF52474.1| (AE003615) ade3 gene product [Drosophila melanoga... 155 5e-37
pir||T16297 hypothetical protein F38B6.4 - Caenorhabditis elegan... 155 7e-37
sp|P00967|PUR2_DROME TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN A... 153 3e-36
emb|CAA24923.1| (X00041) GART [Drosophila melanogaster] 153 3e-36
sp|P16340|PUR2_DROPS TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN A... 148 1e-34
gb|AAF71922.1| (AF236855) GART-B [Gallus gallus] 136 5e-31
gb|AAA62987.1| (U15182) phosphoribosylformylglycinamidine cyclo-... 106 4e-22
pir||T40422 phosphoribosylamine--glycine ligase - fission yeast ... 100 4e-20
sp|P40178|PUR5_STRFR PUTATIVE PHOSPHORIBOSYLFORMYLGLYCINAMIDINE ... 93 4e-18
gb|AAB46604.1| (U85779) aminoimidazole ribotide synthetase [Myco... 87 4e-16
gb|AAB70813.1| (AF008654) glycinamide ribonucleotide formyltrans... 78 1e-13
gb|AAA62985.1| (U15182) phosphoribosylamine-glycine ligase [Myco... 78 2e-13
sp|Q58089|Y676_METJA PUTATIVE HYDROGENASE EXPRESSION/FORMATION P... 73 6e-12
pir||B69125 hydrogenase expression/formation protein HypE - Meth... 69 5e-11
gb|AAC26158.1| (AF035751) HypE [Synechococcus PCC7002] 69 7e-11
>pir||F75014 phosphoribosylformylglycinamidine cyclo-ligase (purm) PAB1083 -
Pyrococcus abyssi (strain Orsay)
>gi|5459070|emb|CAB50556.1| (AJ248288)
phosphoribosylformylglycinamidine cyclo-ligase (purM)
[Pyrococcus abyssi]
Length = 334
Score = 669 bits (1707), Expect = 0.0
Identities = 334/334 (100%), Positives = 334/334 (100%)
Query: 1 MLTYAQAGVDEEKTARALREIIRTARETFKLRKGKVGEPGDIGHYAALLDFGNFYLAMTT 60
MLTYAQAGVDEEKTARALREIIRTARETFKLRKGKVGEPGDIGHYAALLDFGNFYLAMTT
Sbjct: 1 MLTYAQAGVDEEKTARALREIIRTARETFKLRKGKVGEPGDIGHYAALLDFGNFYLAMTT 60
Query: 61 DGVGTKVLVAEAVGKFDTIGIDMIAMNVNDLLCVGAEPLALVDYFAVKEPNEEVFKQVAK 120
DGVGTKVLVAEAVGKFDTIGIDMIAMNVNDLLCVGAEPLALVDYFAVKEPNEEVFKQVAK
Sbjct: 61 DGVGTKVLVAEAVGKFDTIGIDMIAMNVNDLLCVGAEPLALVDYFAVKEPNEEVFKQVAK 120
Query: 121 GLYKGAEEAGVAIVGGETAVMPDLINGYDLAGTAIGIVEKGKVITGERIRPGDSVIGISS 180
GLYKGAEEAGVAIVGGETAVMPDLINGYDLAGTAIGIVEKGKVITGERIRPGDSVIGISS
Sbjct: 121 GLYKGAEEAGVAIVGGETAVMPDLINGYDLAGTAIGIVEKGKVITGERIRPGDSVIGISS 180
Query: 181 SGIHSNGLTLARKLLIPKYGLDYEYEGRKLWEWLLEPTRIYVRPILELINSVEVHGLAHI 240
SGIHSNGLTLARKLLIPKYGLDYEYEGRKLWEWLLEPTRIYVRPILELINSVEVHGLAHI
Sbjct: 181 SGIHSNGLTLARKLLIPKYGLDYEYEGRKLWEWLLEPTRIYVRPILELINSVEVHGLAHI 240
Query: 241 TGGGLLNLKRLTNYGFELEMPPIEGIFKLIHENGVPLDEMFRVFNMGVGFIVVVPQEEKE 300
TGGGLLNLKRLTNYGFELEMPPIEGIFKLIHENGVPLDEMFRVFNMGVGFIVVVPQEEKE
Sbjct: 241 TGGGLLNLKRLTNYGFELEMPPIEGIFKLIHENGVPLDEMFRVFNMGVGFIVVVPQEEKE 300
Query: 301 EALEILSRHYKSYELGNVTRELGKIKVKNYGITL 334
EALEILSRHYKSYELGNVTRELGKIKVKNYGITL
Sbjct: 301 EALEILSRHYKSYELGNVTRELGKIKVKNYGITL 334
>pir||F71457 probable phosphoribosylformylglycinamide cyclo-ligase - Pyrococcus
horikoshii >gi|3256706|dbj|BAA29389.1| (AP000001) 334aa
long hypothetical phosphoribosylformylglycinamide
cyclo-ligase [Pyrococcus horikoshii]
Length = 334
Score = 581 bits (1481), Expect = e-165
Identities = 280/334 (83%), Positives = 313/334 (92%)
Query: 1 MLTYAQAGVDEEKTARALREIIRTARETFKLRKGKVGEPGDIGHYAALLDFGNFYLAMTT 60
MLTYAQAGVDEEKTA+ALR II AR TFK R K+GEPGDIGHY+ALLDF +FYLA+TT
Sbjct: 1 MLTYAQAGVDEEKTAKALRAIIDAARRTFKFRMNKIGEPGDIGHYSALLDFKDFYLAITT 60
Query: 61 DGVGTKVLVAEAVGKFDTIGIDMIAMNVNDLLCVGAEPLALVDYFAVKEPNEEVFKQVAK 120
DGVGTK+LVAEAV KFDTIGIDMIAMNVNDL+CVGAEP+ALVDY AVKEPNE+VF+Q+AK
Sbjct: 61 DGVGTKILVAEAVNKFDTIGIDMIAMNVNDLICVGAEPVALVDYLAVKEPNEDVFQQIAK 120
Query: 121 GLYKGAEEAGVAIVGGETAVMPDLINGYDLAGTAIGIVEKGKVITGERIRPGDSVIGISS 180
GLY+GA+EAG+AIVGGETAVMPDLINGYDLAGTA+GIVEK KV+TGE+I+P D VIGISS
Sbjct: 121 GLYEGAKEAGIAIVGGETAVMPDLINGYDLAGTAVGIVEKDKVVTGEKIKPDDIVIGISS 180
Query: 181 SGIHSNGLTLARKLLIPKYGLDYEYEGRKLWEWLLEPTRIYVRPILELINSVEVHGLAHI 240
SGIHSNGLTLARKLLIPKYGLDYEY G+KLWEWLLEPTRIYV+PIL+LIN VEVHGLAHI
Sbjct: 181 SGIHSNGLTLARKLLIPKYGLDYEYNGKKLWEWLLEPTRIYVKPILKLINEVEVHGLAHI 240
Query: 241 TGGGLLNLKRLTNYGFELEMPPIEGIFKLIHENGVPLDEMFRVFNMGVGFIVVVPQEEKE 300
TGGGLLNLKRLT YGFELEMPPI+GIFKLI+ENGVPL+EMFRVFNMGVGF+V+VPQEEKE
Sbjct: 241 TGGGLLNLKRLTKYGFELEMPPIDGIFKLIYENGVPLEEMFRVFNMGVGFMVIVPQEEKE 300
Query: 301 EALEILSRHYKSYELGNVTRELGKIKVKNYGITL 334
AL+IL+++Y+S+ELG V +E KIKVKNYGITL
Sbjct: 301 NALQILNKYYESFELGKVIKEPEKIKVKNYGITL 334
>sp|O27272|PUR5_METTH PROBABLE PHOSPHORIBOSYLFORMYLGLYCINAMIDINE CYCLO-LIGASE (AIRS)
(PHOSPHORIBOSYL-AMINOIMIDAZOLE SYNTHETASE) (AIR
SYNTHASE) >gi|7437992|pir||G69027
phosphoribosylformylglycinamidine cyclo-ligase -
Methanobacterium thermoautotrophicum (strain Delta H)
>gi|2622313|gb|AAB85693.1| (AE000888)
phosphoribosylformylglycinamidine cyclo-ligase
[Methanobacterium thermoautotrophicum]
Length = 338
Score = 300 bits (759), Expect = 2e-80
Identities = 165/335 (49%), Positives = 227/335 (67%), Gaps = 13/335 (3%)
Query: 1 MLTYAQAGVDEEKTARALREIIRTARETFKLRKGKVGEPGDIGHYAALLDFGNFYLAMTT 60
M+TY+++GVD + + + +T K G GH+AAL+ G+ +AM+T
Sbjct: 1 MVTYSESGVDIDLEELTVSSLTSRLSDTLKYCDVITGA----GHFAALVRMGDVAIAMST 56
Query: 61 DGVGTKVLVAEAVGKFDTIGIDMIAMNVNDLLCVGAEPLALVDYFAVKEPNEEVFKQVAK 120
DGVG+K+LVAE + ++DT+GID IAM VND+LCVGA P ALVDY AV+ P+ EV ++ K
Sbjct: 57 DGVGSKILVAEMMNRYDTVGIDCIAMVVNDILCVGARPAALVDYLAVERPDPEVAGEIGK 116
Query: 121 GLYKGAEEAGVAIVGGETAVMPDLINGYDLAGTAIGIVEKGKVITGERIRPGDSVIGISS 180
GL GAE A VAI+GGETA +P +I DLA T IG V+ ++ITGE + PGD+VIG+ S
Sbjct: 117 GLAMGAEMARVAIIGGETASLPGIIRNLDLAATGIGFVDVDRIITGEDVSPGDTVIGLES 176
Query: 181 SGIHSNGLTLARKLLIPKYGLDYEYE----GRKLWEWLLEPTRIYVRPILELINS-VEVH 235
SGIHSNGL+LAR++ + L E E + + LL PTRIYV PI+ELI S V+VH
Sbjct: 177 SGIHSNGLSLARRVFFDELELSPEDEMPGSSSSVGDELLRPTRIYVEPIMELIESDVDVH 236
Query: 236 GLAHITGGGLLNLKRL-TNYGFELE-MPPIEGIFKLIHENGVPLDEMFRVFNMGVGFIVV 293
GLAHITGGG NLKRL + G+ L+ +P + IF++IHE GV + EM+RVFNMGVGF V
Sbjct: 237 GLAHITGGGFGNLKRLRKDVGYRLDSLPEPQQIFRVIHEAGVDIREMYRVFNMGVGFCAV 296
Query: 294 VPQEEKEEALEILSRHYKSYELGNVTRELGKIKVK 328
V ++ +EAL IL +++ +G VT +++++
Sbjct: 297 VAPDDVDEALSILGD--RAHPIGEVTDRGSEVELE 329
>sp|Q57656|PUR5_METJA PROBABLE PHOSPHORIBOSYLFORMYLGLYCINAMIDINE CYCLO-LIGASE (AIRS)
(PHOSPHORIBOSYL-AMINOIMIDAZOLE SYNTHETASE) (AIR
SYNTHASE) >gi|2129200|pir||D64325
phosphoribosylformylglycinamidine cyclo-ligase (EC
6.3.3.1) - Methanococcus jannaschii
>gi|1590946|gb|AAB98187.1| (U67476)
phosphoribosylformylglycinamidine cyclo-ligase (purM)
[Methanococcus jannaschii]
Length = 350
Score = 294 bits (744), Expect = 1e-78
Identities = 160/322 (49%), Positives = 219/322 (67%), Gaps = 22/322 (6%)
Query: 1 MLTYAQAGVD---EEKTARALREIIRTARETFKLRKGKVGEPGDIG-HYAALLDFGNFYL 56
M+TY AGVD E+K +AL I R K P ++G HYA ++FG++YL
Sbjct: 1 MVTYKDAGVDISHEDKVIKALVSQITFKRSDIK--------PAELGLHYAGAVEFGDYYL 52
Query: 57 AMTTDGVGTKVLVAEAVGKFDTIGIDMIAMNVNDLLCVGAEPLALVDYFAVKEPNEEVFK 116
++TDGVG+K++VAE KFDT+GIDMIAMNVND +C+GAEP+ALVDY AV EE+ +
Sbjct: 53 VLSTDGVGSKMIVAEMANKFDTVGIDMIAMNVNDAICIGAEPIALVDYLAVGHITEEIAE 112
Query: 117 QVAKGLYKGAEEAGVAIVGGETAVMPDLINGYDLAGTAIGIVEKGKVITGERIRPGDSVI 176
Q+ KGL +GA+EA + IVGGETA +PD+I G DLAGT + IV+K ++ITG+ ++ GD ++
Sbjct: 113 QIGKGLNEGAKEANINIVGGETATLPDMIKGIDLAGTVLAIVKKDEIITGKDVKAGDVIV 172
Query: 177 GISSSGIHSNGLTLARKLLIPKYGLDYEYE---GRKLWEWLLEPTRIYVRPILELI--NS 231
G+ SSGIHSNGL+LARK+ LD + G+ + E LL PTRIYV+P+LE+I
Sbjct: 173 GLRSSGIHSNGLSLARKVFFDIAKLDINDKLSYGKTVAEELLTPTRIYVKPVLEMIRDKD 232
Query: 232 VEVHGLAHITGGGLLNLKRLTN---YGFELEMPPIEGIFKLIHENG-VPLDEMFRVFNMG 287
+EV GLAHITGG LKRL + Y + +P IFK I G VP +EMFR FNMG
Sbjct: 233 IEVKGLAHITGGSFRKLKRLNDKVTYYID-NLPEPLPIFKEIQRLGNVPDEEMFRTFNMG 291
Query: 288 VGFIVVVPQEEKEEALEILSRH 309
+GF V+V +E+ + ++I +++
Sbjct: 292 IGFCVIVDEEDANKVIKIANKY 313
>gi|11499283 phosphoribosylformylglycinamidine cyclo-ligase (purM)
[Archaeoglobus fulgidus] >gi|7437993|pir||D69461
phosphoribosylformylglycinamidine cyclo-ligase (purM)
homolog - Archaeoglobus fulgidus
>gi|2648860|gb|AAB89555.1| (AE000986)
phosphoribosylformylglycinamidine cyclo-ligase (purM)
[Archaeoglobus fulgidus]
Length = 329
Score = 289 bits (733), Expect = 2e-77
Identities = 154/317 (48%), Positives = 218/317 (68%), Gaps = 16/317 (5%)
Query: 4 YAQAGVD---EEKTARALREIIRTARETFKLRKGKVGEPGDIGHYAALLDFGNFYLAMTT 60
YA+AGVD EE+ ++L +I+ R F G P HYA ++D G+F + +TT
Sbjct: 6 YAKAGVDIREEERAIKSLASVIKHVRSGF-------GRPILTSHYAGVIDCGDFGITITT 58
Query: 61 DGVGTKVLVAEAVGKFDTIGIDMIAMNVNDLLCVGAEPLALVDYFAVKEPNEEVFKQVAK 120
DGVG+K+LVAE + KFDTIGID +AMNVNDLL +G+EPLA+VDY A+++P+E + ++AK
Sbjct: 59 DGVGSKILVAEKMRKFDTIGIDCVAMNVNDLLAIGSEPLAMVDYIAIEKPDEWIMAEIAK 118
Query: 121 GLYKGAEEAGVAIVGGETAVMPDLINGYDLAGTAIGIVEKGKVITGERIRPGDSVIGISS 180
GL +G A + ++GGETA +P++I G+DLAGTAIG V+K +ITGE+I GD + I S
Sbjct: 119 GLEEGCRIANITLLGGETATLPEIIRGFDLAGTAIGWVKKDAIITGEKIEEGDVIFAIPS 178
Query: 181 SGIHSNGLTLARKLLIPKYGLDY--EYEGRKLWEWLLEPTRIYVRPILELINSVEVHGLA 238
SGIHSNGLTLARK ++ GL Y ++ + + E LL PTRIY+ IL+++ EVHGLA
Sbjct: 179 SGIHSNGLTLARK-VVEAAGLSYHDKFGDKTIGEELLTPTRIYME-ILDVLRECEVHGLA 236
Query: 239 HITGGGLLNLKRLTNYGFELEMP-PIEGIFKLIHENG-VPLDEMFRVFNMGVGFIVVVPQ 296
HITG GLL LKRL N + ++ P + IF+ I + G V EM+R FNMG+GF+V++P+
Sbjct: 237 HITGSGLLKLKRLKNMKYVIDKPLKPQEIFRFIQKLGEVEEAEMYRTFNMGMGFMVILPE 296
Query: 297 EEKEEALEILSRHYKSY 313
+E ++ ++ Y
Sbjct: 297 DEADKLKKLCEGRVVGY 313
>emb|CAB57665.1| (Y18930) phosphoribosylformylglycinamidine cyclo-ligase (AIRS)
(phosphoribosyl-aminoimidazole synthetase, AIR synthase)
[Sulfolobus solfataricus]
Length = 323
Score = 268 bits (677), Expect = 8e-71
Identities = 152/328 (46%), Positives = 209/328 (63%), Gaps = 18/328 (5%)
Query: 4 YAQAGVDEEKTARALREIIRTARETFKLRKGKVGEPGDIGHYAALLDFGNFYLAMTTDGV 63
Y +AGVD EK I + T+K +G GHY+ ++ G+ +AM TDGV
Sbjct: 6 YKKAGVDLEKLRNYHNMISQIISSTYK--NTIIGA----GHYSGVIKIGSLNIAMHTDGV 59
Query: 64 GTKVLVAEAVGKFDTIGIDMIAMNVNDLLCVGAEPLALVDYFAVKEPNEEVFKQVAKGLY 123
GTK +A +GID +AMNVNDL+CVGA+P+ALVDY A++ P + V ++ G+
Sbjct: 60 GTKTFLALQTRIIKPVGIDCVAMNVNDLICVGAKPVALVDYIALERPMDNVVNEIIDGIV 119
Query: 124 KGAEEAGVAIVGGETAVMPDLINGYDLAGTAIGIVEKGKVITGERIRPGDSVIGISSSGI 183
+GA+EA V ++GGETA+MPD+I G+DL+ TAIG+V+K K TG IRPGD V+G+ SSGI
Sbjct: 120 QGAKEADVEVIGGETAIMPDVIRGFDLSCTAIGVVDKLK--TGAEIRPGDYVLGLESSGI 177
Query: 184 HSNGLTLARKLLIP-KYGLDYEYEGRKLWEWLLEPTRIYVRPILELINSVEVHGLAHITG 242
H+NG +L RKL+ K LD EY+ LL+PT+IYV+PILE++N ++ G AH+TG
Sbjct: 178 HANGYSLVRKLIEEGKLSLD-EYKNE-----LLKPTKIYVKPILEVMNMIK--GAAHVTG 229
Query: 243 GGLLNLKRLTNYGFELEMPPIEGIFKLIHENGVPLDEMFRVFNMGVGFIVVVPQEEKEEA 302
G LKRLT+Y L MP IFK I + GV +EM++VFNMG+G ++ V +E +E
Sbjct: 230 GAFSKLKRLTSYKIVLNMPDPPQIFKTIEKAGVAHEEMYKVFNMGIGIVLFVSEELMKEV 289
Query: 303 LEILSRHYKSYELGNVTRELGKIKVKNY 330
L + YELG V G I +K Y
Sbjct: 290 KTKLEGYGTVYELGRVYNGNG-ITIKTY 316
>gb|AAK40944.1| Phosphoribosylformylglycinamidine cyclo-ligase (AIR synthetase)
(AIRS) (purM) [Sulfolobus solfataricus]
Length = 323
Score = 268 bits (677), Expect = 8e-71
Identities = 152/328 (46%), Positives = 209/328 (63%), Gaps = 18/328 (5%)
Query: 4 YAQAGVDEEKTARALREIIRTARETFKLRKGKVGEPGDIGHYAALLDFGNFYLAMTTDGV 63
Y +AGVD EK I + T+K +G GHY+ ++ G+ +AM TDGV
Sbjct: 6 YKKAGVDLEKLRNYHNMISQIISSTYK--NTIIGA----GHYSGVIKIGSLNIAMHTDGV 59
Query: 64 GTKVLVAEAVGKFDTIGIDMIAMNVNDLLCVGAEPLALVDYFAVKEPNEEVFKQVAKGLY 123
GTK +A +GID +AMNVNDL+CVGA+P+ALVDY A++ P + V ++ G+
Sbjct: 60 GTKTFLALQTRIIKPVGIDCVAMNVNDLICVGAKPVALVDYIALERPMDNVVNEIIDGIV 119
Query: 124 KGAEEAGVAIVGGETAVMPDLINGYDLAGTAIGIVEKGKVITGERIRPGDSVIGISSSGI 183
+GA+EA V ++GGETA+MPD+I G+DL+ TAIG+V+K K TG IRPGD V+G+ SSGI
Sbjct: 120 QGAKEADVEVIGGETAIMPDVIRGFDLSCTAIGVVDKLK--TGAEIRPGDYVLGLESSGI 177
Query: 184 HSNGLTLARKLLIP-KYGLDYEYEGRKLWEWLLEPTRIYVRPILELINSVEVHGLAHITG 242
H+NG +L RKL+ K LD EY+ LL+PT+IYV+PILE++N ++ G AH+TG
Sbjct: 178 HANGYSLVRKLIEEGKLSLD-EYKNE-----LLKPTKIYVKPILEVMNMIK--GAAHVTG 229
Query: 243 GGLLNLKRLTNYGFELEMPPIEGIFKLIHENGVPLDEMFRVFNMGVGFIVVVPQEEKEEA 302
G LKRLT+Y L MP IFK I + GV +EM++VFNMG+G ++ V +E +E
Sbjct: 230 GAFSKLKRLTSYKIVLNMPDPPQIFKTIEKAGVAHEEMYKVFNMGIGIVLFVSEELMKEV 289
Query: 303 LEILSRHYKSYELGNVTRELGKIKVKNY 330
L + YELG V G I +K Y
Sbjct: 290 KTKLEGYGTVYELGRVYNGNG-ITIKTY 316
>emb|CAC11238.1| (AL445063) probable phosphoribosyl-aminoimidazole synthetase
[Thermoplasma acidophilum]
Length = 338
Score = 261 bits (659), Expect = 1e-68
Identities = 131/321 (40%), Positives = 203/321 (62%), Gaps = 8/321 (2%)
Query: 20 EIIRTARETFKLRKGKVGEPGDIGHYAALLDFGNFYLAMTTDGVGTKVLVAEAVGKFDTI 79
E + T K + G IG + +++D GNF + DGVGTK ++AEAV K+DT+
Sbjct: 16 EFVNTFIRQLKFHREDFKNIGYIGGFTSIIDMGNFGITFNNDGVGTKAMIAEAVNKYDTL 75
Query: 80 GIDMIAMNVNDLLCVGAEPLALVDYFAVKEPNEEVFKQVAKGLYKGAEEAGVAIVGGETA 139
GID +AMNVND + VG+EP+A+VDY AV + +EE+ KQ+ G GA+ A ++IVGGETA
Sbjct: 76 GIDCVAMNVNDAITVGSEPIAMVDYLAVNKMDEEMAKQLGTGFNVGAQMANISIVGGETA 135
Query: 140 VMPDLINGYDLAGTAIGIVEKGKVITGERIRPGDSVIGISSSGIHSNGLTLARKLLIPKY 199
V+PD++ D++G IGIV+K ++ITG I+ GD +IG+ SSG+HSNG T RK +I
Sbjct: 136 VLPDVVKHIDISGAVIGIVQKNQIITGSNIKEGDVIIGLGSSGLHSNGFTTVRK-IIADN 194
Query: 200 GLD----YEYEGRKLWEWLLEPTRIYVRPILELINSVEVHGLAHITGGGLLNLKRLTNYG 255
LD + + +K +E LLEPTRIYVR IL+++ + + G+A+ITGGG N+ R+ +
Sbjct: 195 NLDLQDTFPGDSKKTYEVLLEPTRIYVREILDIMGIITIKGMANITGGGFKNITRMKDMK 254
Query: 256 FELEMP--PIEGIFKLIHENGVPLDEMFRVFNMGVGFIVVVPQEEKEEALEILSRHYKSY 313
+ ++ P P +L+ + +MF +FNMG GF++V+ ++EK + + L
Sbjct: 255 YVIDDPFEPQNVFIRLMEMGNLNYAQMFEIFNMGTGFVLVIDEDEKVDIMNALKGKVPVK 314
Query: 314 ELGNVTRELGKIKVKNYGITL 334
+G+V G +++ Y ++L
Sbjct: 315 VMGHVENGSG-VEIPKYEVSL 334
>gb|AAG19319.1| (AE005027) phosphoribosylformylglycinamidine cycloligase; PurM
[Halobacterium sp. NRC-1]
Length = 331
Score = 255 bits (645), Expect = 5e-67
Identities = 145/301 (48%), Positives = 186/301 (61%), Gaps = 18/301 (5%)
Query: 2 LTYAQAGVDEEKTARALREIIRTARETFKLRKGKVGEPGDIGHYAALLDFGNFYLAMTTD 61
LTYA AGVD + A ++ A D YA L+D G+ YLA+ TD
Sbjct: 14 LTYADAGVDIADSEAATAALVDAA-----------STGTDDTAYAGLVDLGDQYLALATD 62
Query: 62 GVGTKVLVAEAVGKFDTIGIDMIAMNVNDLLCVGAEPLALVDYFAVKEPNEEVFKQVAKG 121
GVGTK+LVAEAVG + T+GID IAMNVNDLL G EP A VDY AV EPNE ++ G
Sbjct: 63 GVGTKLLVAEAVGDYSTVGIDCIAMNVNDLLAAGVEPAAFVDYLAVDEPNERRAAELGDG 122
Query: 122 LYKGAEEAGVAIVGGETAVMPDLINGYDLAGTAIGIVEKGKVITGERIRPGDSVIGISSS 181
L GA+ AGVA+VGGETAVMPD++ G+D+AGTA G+ ++ G R GD+++G S+
Sbjct: 123 LAAGADAAGVALVGGETAVMPDVVRGFDIAGTAAGVATDAELFPG-RAEAGDALVGFPSA 181
Query: 182 GIHSNGLTLARKLLIPKYGLD--YEYEG-RKLWEWLLEPTRIYVRPILELINSVEVHGLA 238
GIHSNGLTLAR+ G D Y YEG + + LLEPTRIY +L+ VH A
Sbjct: 182 GIHSNGLTLAREAATRDGGYDEPYPYEGYETVGDALLEPTRIYTH-LLDAFREHGVHAAA 240
Query: 239 HITGGGLLNLKRLTNYGFELEMP-PIEGIFKLIHE-NGVPLDEMFRVFNMGVGFIVVVPQ 296
HITGGG NL R+ + +E+ P P + +F + + GV EM R FNMG GF+V +P+
Sbjct: 241 HITGGGWTNLDRMGGFRYEVSDPLPAQPVFDYVQDAGGVSDAEMHRTFNMGTGFVVALPE 300
Query: 297 E 297
+
Sbjct: 301 D 301
>sp|P12043|PUR5_BACSU PHOSPHORIBOSYLFORMYLGLYCINAMIDINE CYCLO-LIGASE (AIRS)
(PHOSPHORIBOSYL-AMINOIMIDAZOLE SYNTHETASE) (AIR
SYNTHASE) >gi|68628|pir||AJBSCL
phosphoribosylformylglycinamidine cyclo-ligase (EC
6.3.3.1) [validated] - Bacillus subtilis
>gi|143371|gb|AAA22681.1| (J02732) phosphoribosyl
aminoimidazole synthetase (PUR-M) [Bacillus subtilis]
>gi|2632964|emb|CAB12470.1| (Z99107)
phosphoribosylaminoimidazole synthetase [Bacillus
subtilis]
Length = 346
Score = 235 bits (594), Expect = 5e-61
Identities = 136/338 (40%), Positives = 203/338 (59%), Gaps = 23/338 (6%)
Query: 4 YAQAGVDEEKTARALREIIRTARETFKLRKGKVGEPGDIGHYAALLDFGNF-----YLAM 58
Y AGVD E A++ + + T +L G G +G + + D L
Sbjct: 5 YKNAGVDIEAGYEAVKRMKKHVERTKRL-----GVMGSLGGFGGMFDLSELSYQKPVLIS 59
Query: 59 TTDGVGTKVLVAEAVGKFDTIGIDMIAMNVNDLLCVGAEPLALVDYFAVKEPNEEVFKQV 118
TDGVGTK+ +A ++ K DTIG+D +AM VND+L GAEPL +DY AV + + +Q+
Sbjct: 60 GTDGVGTKLKLAFSMDKHDTIGVDAVAMCVNDVLAQGAEPLFFLDYLAVGKADPVKIEQI 119
Query: 119 AKGLYKGAEEAGVAIVGGETAVMPDLING--YDLAGTAIGIVEKGKVITGERIRPGDSVI 176
+G+ +G E++G A+VGGETA MP L YD+AG ++G+ EK +++TGE+I G +I
Sbjct: 120 VQGVAEGCEQSGSALVGGETAEMPGLYTADEYDIAGFSVGVAEKDEIVTGEKIEEGHLLI 179
Query: 177 GISSSGIHSNGLTLARKLLI--PKYGLDYEYE--GRKLWEWLLEPTRIYVRPILELINSV 232
G+SSSG+HSNG +L RK+L+ + LD YE R L + L+EPTRIYV+P+L + S
Sbjct: 180 GLSSSGLHSNGFSLVRKVLLDDAAWDLDTTYEPFERPLGQELVEPTRIYVKPVLAAVKSG 239
Query: 233 EVHGLAHITGGGLL-NLKRLTNYGFELEMP----PIEGIFKLIHENG-VPLDEMFRVFNM 286
++ G+AH+TGGG + N+ R+ G E+ PI IF + E G + ++MF VFNM
Sbjct: 240 KIDGMAHVTGGGFIENIPRMLPEGLSAEIDHGSWPIPPIFSFLQEYGKLKEEDMFNVFNM 299
Query: 287 GVGFIVVVPQEEKEEALEILSRH-YKSYELGNVTRELG 323
G+GF++ V +E + + L H K+Y +G V + G
Sbjct: 300 GIGFVLAVKEEHLTDVIGTLESHGEKAYLIGRVKKGEG 337
>pir||E70367 phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1) -
Aquifex aeolicus >gi|2983329|gb|AAC06918.1| (AE000706)
phosphoribosylformylglycinamidine cyclo-ligase [Aquifex
aeolicus]
Length = 331
Score = 230 bits (580), Expect = 2e-59
Identities = 141/329 (42%), Positives = 197/329 (59%), Gaps = 19/329 (5%)
Query: 1 MLTYAQAGVDEEKTARALREIIRTARETFKLRKGKVGEPGDIGHYAALLDFGNFYLAMTT 60
M+TY AGVD +K ++ I ++ F L E G + + L TT
Sbjct: 1 MVTYRSAGVDIDKANEFVKFIKEKVKKEFNLE-----EFGGFASGFPIKGYKKPILFSTT 55
Query: 61 DGVGTKVLVAEAVGKFDTIGIDMIAMNVNDLLCVGAEPLALVDYFAVKEPNEEVFKQVAK 120
DGVGTK+ VA+AVG +T+GID++AMNVNDL+ GA+P +DY A + + EV KQV +
Sbjct: 56 DGVGTKLKVAQAVGVHNTVGIDLVAMNVNDLITTGADPFIFLDYIATGKLDLEVMKQVME 115
Query: 121 GLYKGAEEAGVAIVGGETAVMPDLI--NGYDLAGTAIGIVEKGKVITGERIRPGDSVIGI 178
G+ KG E V + GGETA MP YDLAG +G+ E+ +VITG+ I+PGD ++G+
Sbjct: 116 GIIKGCREGEVILAGGETAEMPGFYPEGVYDLAGFCVGLCEEDEVITGKEIKPGDLLLGL 175
Query: 179 SSSGIHSNGLTLARKLL---IPKYGLDYEYEGRKLWEWLLEPTRIYVRPILELINSVEVH 235
SSG HSNG +L RK+L Y E G+K+WE LL PTRIYV+ I +L +V++
Sbjct: 176 PSSGFHSNGYSLIRKVLEMNNVSYEDYVEELGKKVWEVLLVPTRIYVKEIKKLKKNVKIK 235
Query: 236 GLAHITGGGL-LNLKRLTNYGFEL----EMPPIEGIFKLIHENG-VPLDEMFRVFNMGVG 289
G+AHITGGG+ NL R+ G + + P +F I G V EMFR FNMGVG
Sbjct: 236 GIAHITGGGIPENLIRILPEGTKAVVYKKNIPQNPVFSWIQRLGNVEEREMFRTFNMGVG 295
Query: 290 FIVVVPQEEKEEALEILSRHYKSYELGNV 318
IV++ +EE ++A E++ +S+ LG +
Sbjct: 296 MIVILDKEEFDKARELIP---ESFYLGEI 321
>dbj|BAA89440.1| (AB003158) 5'-phosphoribosyl-5-aminoimidazole synthetase
[Corynebacterium ammoniagenes]
Length = 351
Score = 224 bits (564), Expect = 2e-57
Identities = 139/332 (41%), Positives = 202/332 (59%), Gaps = 21/332 (6%)
Query: 3 TYAQAGVDEEKTARALREIIRTARETFKLRKGKVGEPGDIGHYAALLDFGNF---YLAMT 59
TYA AGV+ E+ RA+ A+ R + G +G +A L G + LA
Sbjct: 5 TYAAAGVNIEEGDRAVELFAPLAK-----RATRPEVMGGLGGFAGLFKLGEYKEPILAAG 59
Query: 60 TDGVGTKVLVAEAVGKFDTIGIDMIAMNVNDLLCVGAEPLALVDYFAVKEPNEEVFKQVA 119
+DGVGTK+ VA+A+ K DTIGID++AM V+DL+ GAEPL L DY AV + E Q+
Sbjct: 60 SDGVGTKLAVAQAMDKHDTIGIDLVAMCVDDLVVCGAEPLFLQDYIAVGKVVPEKVAQIV 119
Query: 120 KGLYKGAEEAGVAIVGGETAVMPDLIN--GYDLAGTAIGIVEKGKVITGERIRPGDSVIG 177
G+ +G +AG A++GGETA P ++N YD++ TA+G+VE +++ +++R GD +I
Sbjct: 120 AGIAEGCVQAGCALLGGETAEHPGVMNEKDYDVSATAVGVVEADELLGPDKVRDGDVLIA 179
Query: 178 ISSSGIHSNGLTLARKLLIPKYGLDYEYE----GRKLWEWLLEPTRIYVRPILELINSVE 233
+ SSG+HSNG +LAR +L+ + GL + GR L E LLEPTRIY + L L++ +
Sbjct: 180 MGSSGLHSNGYSLARHVLLEQAGLPLDGYIDDLGRTLGEELLEPTRIYAKDCLALVSECD 239
Query: 234 VHGLAHITGGGLL-NLKRLTNYGFELEMPPIE----GIFKLIHENG-VPLDEMFRVFNMG 287
V H+TGGGL NL+R+ G E+ IF+ I G V L+EM + FNMG
Sbjct: 240 VATFCHVTGGGLAGNLERVLPEGLVAEVNRASWTPAAIFRTIASFGKVSLEEMEKTFNMG 299
Query: 288 VGFIVVVPQEEKEEALEIL-SRHYKSYELGNV 318
VG I +V E+++ AL +L +RH ++ELG+V
Sbjct: 300 VGMIAIVSPEDRDRALAMLTARHVDAWELGSV 331
>dbj|BAB04350.1| (AP001509) phosphoribosylaminoimidazole synthetase [Bacillus
halodurans]
Length = 345
Score = 221 bits (558), Expect = 8e-57
Identities = 134/339 (39%), Positives = 194/339 (56%), Gaps = 21/339 (6%)
Query: 4 YAQAGVD----EEKTARALREIIRTARETFKLRKGKVGEPGDIGHYAALLDFGNFYLAMT 59
Y QAGVD E AR + ++RTAR G G D+ + L+ L
Sbjct: 5 YKQAGVDIEAGYEAVARMKKHVLRTARPEVIGGLGSFGGMFDL----SALNMKEPVLVSG 60
Query: 60 TDGVGTKVLVAEAVGKFDTIGIDMIAMNVNDLLCVGAEPLALVDYFAVKEPNEEVFKQVA 119
TDGVGTK+++A + K DTIG+D +AM VND++ GAEPL +DY A + + +
Sbjct: 61 TDGVGTKLMLAFQMNKHDTIGVDAVAMCVNDIVVQGAEPLYFLDYIACGKSEPARIEAIV 120
Query: 120 KGLYKGAEEAGVAIVGGETAVMPDLIN--GYDLAGTAIGIVEKGKVITGERIRPGDSVIG 177
KG+ G E+AG A++GGETA MP + + YD+AG A+G VEK ++TG I GD ++G
Sbjct: 121 KGIADGCEQAGCALIGGETAEMPGMYDETEYDVAGFAVGAVEKADLVTGADIESGDLILG 180
Query: 178 ISSSGIHSNGLTLARKLLIPKYGLDYEYE----GRKLWEWLLEPTRIYVRPILELINSVE 233
+ SSG+HSNG +L RK+L+ +G + E G+KL E LL PT+IYV+ +L+ + + +
Sbjct: 181 LPSSGVHSNGFSLVRKILLHDHGYTLDSEIPALGKKLGEELLTPTKIYVKTVLQTLKTGK 240
Query: 234 VHGLAHITGGGLL-NLKRLTNYGFELEMP----PIEGIFKLIHENG-VPLDEMFRVFNMG 287
V GL+HITGGG N+ R+ G E+ P+ IF I E G + +MF FNMG
Sbjct: 241 VKGLSHITGGGFYENVPRMLPEGLGAEIDYGSWPVPPIFSFIRETGQLSAKDMFSTFNMG 300
Query: 288 VGFIVVVPQEEKEEAL-EILSRHYKSYELGNVTRELGKI 325
+G VVV ++ + +I +Y +G VT G +
Sbjct: 301 IGMAVVVSSDDAPHVIRQIQETGEDAYIIGRVTDTSGVV 339
>pir||F81911 probable phosphoribosylformylglycinamidine cyclo-ligase (EC
6.3.3.1) NMA1421 [imported] - Neisseria meningitidis
(group A strain Z2491) >gi|7380080|emb|CAB84661.1|
(AL162755) putative phosphoribosylformylglycinamidine
cyclo-ligase [Neisseria meningitidis Z2491]
Length = 344
Score = 215 bits (541), Expect = 7e-55
Identities = 132/337 (39%), Positives = 198/337 (58%), Gaps = 20/337 (5%)
Query: 2 LTYAQAGVDEEKTARALREIIRTARETFKLRKGKVGEPGDIGHYAALLDFGNFY----LA 57
L+Y AGVD + + + I A+ T + GD+G + AL++ G Y L
Sbjct: 5 LSYRDAGVDIDAGDQLVENIKPFAKRTMRPEV-----LGDLGGFGALVEIGKKYKNPVLV 59
Query: 58 MTTDGVGTKVLVAEAVGKFDTIGIDMIAMNVNDLLCVGAEPLALVDYFAVKEPNEEVFKQ 117
TDGVGTK+ +A K DT+GID++AM+VND+L GAEPL +DYFA + +
Sbjct: 60 SGTDGVGTKLKLAFDWDKHDTVGIDLVAMSVNDILVQGAEPLFFLDYFACGKLDVPRATD 119
Query: 118 VAKGLYKGAEEAGVAIVGGETAVMPDL--INGYDLAGTAIGIVEKGKVITGERIRPGDSV 175
V KG+ +G EE+G A++GGETA MP + + YDLAG A+G+VEK VITG I GD V
Sbjct: 120 VIKGIAQGCEESGCALIGGETAEMPGMYPVGEYDLAGFAVGVVEKENVITGRSIGAGDVV 179
Query: 176 IGISSSGIHSNGLTLARKLL-IPKYGLDYEYE-GRKLWEWLLEPTRIYVRPILELINSVE 233
+G++S+G HSNG +L RK++ LD E++ G+ L E ++ PTR+YV+PIL +
Sbjct: 180 LGLASNGAHSNGYSLIRKIIERDNPDLDAEFDNGKTLREAVIAPTRLYVKPILAALEKFT 239
Query: 234 VHGLAHITGGGLL-NLKRL----TNYGFELEMPPIEGIFKLIHENG-VPLDEMFRVFNMG 287
+ G+AHITGGG+ N+ R+ T + + + +F+ + + G V EM+R FN G
Sbjct: 240 IKGMAHITGGGITENVPRVLPENTVAQIDAKSWELPKLFQWLQKAGNVETQEMYRTFNCG 299
Query: 288 VGFIVVVPQEEKEEALEILSRHYKS-YELGNVTRELG 323
+G +V+V E+ + +L ++ Y LG + G
Sbjct: 300 IGMVVIVAAEDADAVQGLLGEQGETVYRLGLIRERQG 336
>pir||E81104 phosphoribosylformylglycinamidine cyclo-ligase NMB1252 [imported] -
Neisseria meningitidis (group B strain MD58)
>gi|7226492|gb|AAF41632.1| (AE002473)
phosphoribosylformylglycinamidine cyclo-ligase
[Neisseria meningitidis MC58]
Length = 344
Score = 214 bits (540), Expect = 1e-54
Identities = 132/337 (39%), Positives = 198/337 (58%), Gaps = 20/337 (5%)
Query: 2 LTYAQAGVDEEKTARALREIIRTARETFKLRKGKVGEPGDIGHYAALLDFGNFY----LA 57
L+Y AGVD + + + I A+ T + GD+G + AL++ G Y L
Sbjct: 5 LSYRDAGVDIDAGDQLVENIKPFAKRTMRPEV-----LGDLGGFGALVEIGKKYQNPVLV 59
Query: 58 MTTDGVGTKVLVAEAVGKFDTIGIDMIAMNVNDLLCVGAEPLALVDYFAVKEPNEEVFKQ 117
TDGVGTK+ +A K DT+GID++AM+VND+L GAEPL +DYFA + +
Sbjct: 60 SGTDGVGTKLKLAFDWDKHDTVGIDLVAMSVNDILVQGAEPLFFLDYFACGKLDVPRATD 119
Query: 118 VAKGLYKGAEEAGVAIVGGETAVMPDL--INGYDLAGTAIGIVEKGKVITGERIRPGDSV 175
V KG+ +G EE+G A++GGETA MP + + YDLAG A+G+VEK VITG I GD V
Sbjct: 120 VIKGIAQGCEESGCALIGGETAEMPGMYPVGEYDLAGFAVGVVEKENVITGRSIGVGDVV 179
Query: 176 IGISSSGIHSNGLTLARKLL-IPKYGLDYEYE-GRKLWEWLLEPTRIYVRPILELINSVE 233
+G++S+G HSNG +L RK++ LD E++ G+ L E ++ PTR+YV+PIL +
Sbjct: 180 LGLASNGAHSNGYSLIRKIIERDNPDLDAEFDNGKTLREAVIAPTRLYVKPILAALEKFT 239
Query: 234 VHGLAHITGGGLL-NLKRL----TNYGFELEMPPIEGIFKLIHENG-VPLDEMFRVFNMG 287
+ G+AHITGGG+ N+ R+ T + + + +F+ + + G V EM+R FN G
Sbjct: 240 IKGMAHITGGGITENVPRVLPENTVAQIDAKSWELPKLFQWLQKAGNVETQEMYRTFNCG 299
Query: 288 VGFIVVVPQEEKEEALEILSRHYKS-YELGNVTRELG 323
+G +V+V E+ + +L ++ Y LG + G
Sbjct: 300 IGMVVIVAAEDADAVQGLLGEQGETVYRLGLIRERQG 336
>pir||A70809 probable 5'-phosphoribosyl-5-aminoimidazole synthetase -
Mycobacterium tuberculosis (strain H37RV)
>gi|2916867|emb|CAA17615.1| (AL022004) purM
[Mycobacterium tuberculosis]
Length = 364
Score = 213 bits (538), Expect = 2e-54
Identities = 139/339 (41%), Positives = 192/339 (56%), Gaps = 28/339 (8%)
Query: 2 LTYAQAGVDEEKTARALREIIRTARETFKLRKGKVGEP---GDIGHYAALL----DFGNF 54
+TYA AGVD E RA+ + FK K P G +G +A L D+
Sbjct: 17 ITYASAGVDIEAGDRAI--------DLFKPLASKATRPEVRGGLGGFAGLFTLRGDYREP 68
Query: 55 YLAMTTDGVGTKVLVAEAVGKFDTIGIDMIAMNVNDLLCVGAEPLALVDYFAVKEPNEEV 114
LA ++DGVGTK+ +A+A+ K DT+G+D++AM V+DL+ GAEPL L+DY AV E
Sbjct: 69 VLAASSDGVGTKLAIAQAMDKHDTVGLDLVAMVVDDLVVCGAEPLFLLDYIAVGRIVPER 128
Query: 115 FKQVAKGLYKGAEEAGVAIVGGETAVMPDLI--NGYDLAGTAIGIVEKGKVITGERIRPG 172
+ G+ G AG A++GGETA P LI + YD++ T +G+VE V+ +R++PG
Sbjct: 129 LSAIVAGIADGCMRAGCALLGGETAEHPGLIEPDHYDISATGVGVVEADNVLGPDRVKPG 188
Query: 173 DSVIGISSSGIHSNGLTLARKLL--IPKYGLDYEYE--GRKLWEWLLEPTRIYVRPILEL 228
D +I + SSG+HSNG +L RK+L I + L E GR L E LLEPTRIY + L L
Sbjct: 189 DVIIAMGSSGLHSNGYSLVRKVLLEIDRMNLAGHVEEFGRTLGEELLEPTRIYAKDCLAL 248
Query: 229 INSVEVHGLAHITGGGLL-NLKRLTNYGFELEMP----PIEGIFKLIHENG-VPLDEMFR 282
V H+TGGGL NL+R+ +G E+ +F +I + G V EM +
Sbjct: 249 AAETRVRTFCHVTGGGLAGNLQRVIPHGLIAEVDRGTWTPAPVFTMIAQRGRVRRTEMEK 308
Query: 283 VFNMGVGFIVVVPQEEKEEALEIL-SRHYKSYELGNVTR 320
FNMGVG I VV E+ AL +L +RH + LG V +
Sbjct: 309 TFNMGVGMIAVVAPEDTTRALAVLTARHLDCWVLGTVCK 347
>sp|Q99148|PUR2_YARLI BIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADE1 [INCLUDES:
PHOSPHORIBOSYLAMINE--GLYCINE LIGASE (GARS) (GLYCINAMIDE
RIBONUCLEOTIDE SYNTHETASE) (PHOSPHORIBOSYLGLYCINAMIDE
SYNTHETASE); PHOSPHORIBOSYLFORMYLGLYCINAMIDINE
CYCLO-LIGASE (AIRS) (PHOSPHORIBOSYL-AM>
>gi|1117927|gb|AAA85393.1| (U40565) Ade1p [Yarrowia
lipolytica]
Length = 788
Score = 212 bits (535), Expect = 4e-54
Identities = 130/337 (38%), Positives = 201/337 (59%), Gaps = 26/337 (7%)
Query: 2 LTYAQAGVDEEKTARALREIIRTARETFKLRKGKVGEPGDIGHYAALLD-----FGNFYL 56
+TYAQAGV + + +++I + T + G IG + L D F + L
Sbjct: 439 ITYAQAGVSIDNGNKLVQQIKEKVKST-----ARPGTDSVIGGFGGLFDLKAAGFRDPLL 493
Query: 57 AMTTDGVGTKVLVAEAVGKFDTIGIDMIAMNVNDLLCVGAEPLALVDYFAVKEPNEEVFK 116
TDGVGTK+ +A+++ K DT+GID++AMNVNDL+ GAEPL +DY+A + +
Sbjct: 494 VGATDGVGTKLKIAQSIDKHDTVGIDLVAMNVNDLVVQGAEPLVFLDYYATGKLDVNAAA 553
Query: 117 QVAKGLYKGAEEAGVAIVGGETAVMPDLI--NGYDLAGTAIGIVEKGKVITG-ERIRPGD 173
G+ G +AG A++GGETA MP + N YD GT+IG VE+ V+ + I GD
Sbjct: 554 AFVGGVADGCIQAGCALIGGETAEMPGIYYGNDYDANGTSIGAVERDAVLPRMDEIAKGD 613
Query: 174 SVIGISSSGIHSNGLTLARKLLIPKYGLDYE-----YEGRKLWEWLLEPTRIYVRPILEL 228
+++G++SSG+HSNG +L RK +I GL Y + + L E LL PTRIYV+ +L +
Sbjct: 614 AILGLASSGVHSNGFSLVRK-IIEHAGLTYTDACPWDQSKSLGEALLTPTRIYVKQLLPV 672
Query: 229 INSVEVHGLAHITGGGLL-NLKRL--TNYGFELEMP--PIEGIFKLIHENG-VPLDEMFR 282
IN+ LAHITGGGL+ N+ R+ NY ++++ P+ +F+ + + G VP +++ +
Sbjct: 673 INAKLTSALAHITGGGLVENIPRILPENYSAKIDVSTWPLPPVFQWLGKAGNVPKEDISK 732
Query: 283 VFNMGVGFIVVVPQEEKEEALEILSR-HYKSYELGNV 318
NMG+G I+VV QE+ E ++L + K Y++G +
Sbjct: 733 TLNMGIGMILVVKQEKVAEVTQLLEKVGEKVYQIGEI 769
>sp|P52424|PUR5_VIGUN PHOSPHORIBOSYLFORMYLGLYCINAMIDINE CYCLO-LIGASE PRECURSOR (AIRS)
(PHOSPHORIBOSYL-AMINOIMIDAZOLE SYNTHETASE) (AIR
SYNTHASE) >gi|7437995|pir||T10963
phosphoribosylformylglycinamidine cyclo-ligase (EC
6.3.3.1) - cowpea >gi|945060|gb|AAC14578.1| (U30895)
aminoimidazole ribonucleotide (AIRS) synthetase [Vigna
unguiculata]
Length = 388
Score = 211 bits (531), Expect = 1e-53
Identities = 134/331 (40%), Positives = 188/331 (56%), Gaps = 31/331 (9%)
Query: 2 LTYAQAGVDEEKTARALREIIRTARETFKLRKGKVGEPGDIGHYAALLDFGNFYLAMTTD 61
LTY AGVD + A +R I + A PG IG + L G+ YL TD
Sbjct: 66 LTYRDAGVDIDAGAELVRRIAKMA-------------PG-IGGFGGLYPLGDSYLVAGTD 111
Query: 62 GVGTKVLVAEAVGKFDTIGIDMIAMNVNDLLCVGAEPLALVDYFAVKEPNEEVFKQVAKG 121
GVGTK+++A G DTIGID++AM+VND++ GA+PL +DYFA + +V ++V KG
Sbjct: 112 GVGTKLMLAFETGIHDTIGIDLVAMSVNDIVTSGAKPLFFLDYFATGRLDVDVAEKVVKG 171
Query: 122 LYKGAEEAGVAIVGGETAVMPDLI--NGYDLAGTAIGIVEKGKVITGERIRPGDSVIGIS 179
+ G +++ ++GGETA MP L YDL+G A+GIV+K VI G+ I GD +IG+
Sbjct: 172 IVDGCKQSDCVLLGGETAEMPGLYKEGEYDLSGCAVGIVKKDSVINGKNIVAGDVIIGLP 231
Query: 180 SSGIHSNGLTLARKLLIPK-YGLDYEYEGRK--LWEWLLEPTRIYVRPILELINSVEVHG 236
SSG+HSNG +L R++L L + G L E L+ PT IYV+ +L+LI+ V G
Sbjct: 232 SSGVHSNGFSLVRRVLAQSGLSLKDQLPGSNITLAEALMAPTVIYVKQVLDLISKGGVKG 291
Query: 237 LAHITGGGLL-NLKRLTNYGF-------ELEMPPIEGIFKLIHENG-VPLDEMFRVFNMG 287
+AHITGGG N+ R+ G E+P +F+ + E G + EM R FNMG
Sbjct: 292 IAHITGGGFTDNIPRVFPEGLGALIYDGSWEVP---AVFRWLQEAGKIEDSEMRRTFNMG 348
Query: 288 VGFIVVVPQEEKEEALEILSRHYKSYELGNV 318
+G I+VV E LE + K Y +G +
Sbjct: 349 IGMILVVSPEAANRILENKGQADKFYRIGEI 379
>pir||S75786 phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1) -
Synechocystis sp. (strain PCC 6803)
>gi|1001275|dbj|BAA10521.1| (D64003) phosphoribosyl
formylglycinamidine cyclo-ligase [Synechocystis sp.]
Length = 341
Score = 209 bits (526), Expect = 4e-53
Identities = 128/324 (39%), Positives = 181/324 (55%), Gaps = 24/324 (7%)
Query: 2 LTYAQAGVDEEKTARALREIIRTARETFKLRKGKVGEPGDIGHYAALLDFGNFY----LA 57
+ Y QAGVD E + I + TF+ G IG +A L + Y L
Sbjct: 1 MDYRQAGVDVEAGREFVSRIRQQVESTFRPEV-----MGGIGGFAGLFEIPAGYKAPVLV 55
Query: 58 MTTDGVGTKVLVAEAVGKFDTIGIDMIAMNVNDLLCVGAEPLALVDYFAVKEPNEEVFKQ 117
TDGVGTK+ +A+A+ + TIGID++AM VND+L GAEPL +DY A +
Sbjct: 56 SGTDGVGTKLKIAQAMDQHHTIGIDLVAMCVNDILTTGAEPLYFLDYLATGKLEPAQLAD 115
Query: 118 VAKGLYKGAEEAGVAIVGGETAVMPDLING--YDLAGTAIGIVEKGKVITGERIRPGDSV 175
V G+ +G +++G A++GGETA MP YD AG A+GIVEK +++ G ++ GD
Sbjct: 116 VVTGIVEGCKQSGCALLGGETAEMPGFYGAGEYDAAGFAVGIVEKSQLLNGSQVNIGDVA 175
Query: 176 IGISSSGIHSNGLTLARKLLIPKYGLDY-----EYEGRKLWEWLLEPTRIYVRPILELIN 230
I + SSG+HSNG +L RK +I G + E+ G+ L E LEPTRIYV+PI L+
Sbjct: 176 IAVESSGVHSNGFSLVRK-IIESNGWQWSDCLPEWGGQSLGEIFLEPTRIYVKPIQALLK 234
Query: 231 S-VEVHGLAHITGGGL-LNLKRLTNYGFELEM-----PPIEGIFKLIHENGVPLDEMFRV 283
S + +HG+AHITGGGL NL R G +++ P+ L + V M
Sbjct: 235 SGINIHGMAHITGGGLPENLPRCLGQGQSIQVKAGSWQPLPVFNWLADKGQVNSTAMLET 294
Query: 284 FNMGVGFIVVVPQEEKEEALEILS 307
FN+GVGF+V+V E+++ L+ S
Sbjct: 295 FNLGVGFVVLVSPEQRQTTLDFFS 318
>sp|P43848|PUR5_HAEIN PHOSPHORIBOSYLFORMYLGLYCINAMIDINE CYCLO-LIGASE (AIRS)
(PHOSPHORIBOSYL-AMINOIMIDAZOLE SYNTHETASE) (AIR
SYNTHASE) >gi|1073795|pir||G64122
phosphoribosylformylglycinamidine cyclo-ligase (EC
6.3.3.1) - Haemophilus influenzae (strain Rd KW20)
>gi|1574267|gb|AAC23076.1| (U32822)
phosphoribosylaminoimidazole synthetase (purM)
[Haemophilus influenzae Rd]
Length = 344
Score = 207 bits (522), Expect = 1e-52
Identities = 132/331 (39%), Positives = 190/331 (56%), Gaps = 19/331 (5%)
Query: 2 LTYAQAGVDEEKTARALREIIRTARETFKLRKGKVGEPGDIGHYAALLDFGNFY----LA 57
L+Y AGVD + I + T R+ +V G +G + AL Y L
Sbjct: 6 LSYKDAGVDIHTGNELVERIKGDVKRT---RRSEV--MGGLGGFGALCALPTKYKEPILV 60
Query: 58 MTTDGVGTKVLVAEAVGKFDTIGIDMIAMNVNDLLCVGAEPLALVDYFAVKEPNEEVFKQ 117
TDGVGTK+ +A + K DTIG D++AM VNDL+ GAEPL +DY+A + + +V
Sbjct: 61 SGTDGVGTKLRLAIDLKKHDTIGQDLVAMCVNDLIVQGAEPLFFLDYYATGKLDVDVAAS 120
Query: 118 VAKGLYKGAEEAGVAIVGGETAVMPDLIN--GYDLAGTAIGIVEKGKVITGERIRPGDSV 175
V KG+ G E +G A+VGGETA MP + + YDLAG +G+VEK ++I G ++ GD++
Sbjct: 121 VIKGIADGCEMSGCALVGGETAEMPGMYHEGDYDLAGFCVGVVEKSEIIDGTAVKTGDTL 180
Query: 176 IGISSSGIHSNGLTLARKLL-IPKYGLDYEYEGRKLWEWLLEPTRIYVRPILELINSVEV 234
I + SSG HSNG +L RK+L + EG+ L E LL PT+IYV+ IL+LI EV
Sbjct: 181 IALGSSGAHSNGYSLIRKVLEVSGANPTDLLEGKPLSEHLLAPTKIYVKSILQLIKQTEV 240
Query: 235 HGLAHITGGGLL-NLKRL----TNYGFELEMPPIEGIFKLIHENG-VPLDEMFRVFNMGV 288
H +AH+TGGG N+ R+ T + IF + E G + EM+R FN GV
Sbjct: 241 HAIAHLTGGGFWENIPRVLPDNTKAVIDESSWQWPAIFNWLQEKGNISRYEMYRTFNCGV 300
Query: 289 GFIVVVPQEEKEEALEILSRH-YKSYELGNV 318
G ++ +P++E E AL +L + K++ +G +
Sbjct: 301 GMVIALPEKEVETALALLEQSGEKAWVIGKI 331
>pir||T47640 phosphoribosylformylglycinamidine cyclo-ligase precursor -
Arabidopsis thaliana >gi|7329631|emb|CAB82696.1|
(AL132970) phosphoribosylformylglycinamidine
cyclo-ligase precursor [Arabidopsis thaliana]
Length = 389
Score = 205 bits (517), Expect = 5e-52
Identities = 132/337 (39%), Positives = 189/337 (55%), Gaps = 32/337 (9%)
Query: 2 LTYAQAGVDEEKTARALREIIRTARETFKLRKGKVGEPGDIGHYAALLDFGNFYLAMTTD 61
L Y +GVD + A ++ I + A PG IG + L G+ YL TD
Sbjct: 66 LNYKDSGVDIDAGAELVKRIAKMA-------------PG-IGGFGGLFPLGDSYLVAGTD 111
Query: 62 GVGTKVLVAEAVGKFDTIGIDMIAMNVNDLLCVGAEPLALVDYFAVKEPNEEVFKQVAKG 121
GVGTK+ +A G DTIGID++AM+VND++ GA+PL +DYFA + ++ ++V KG
Sbjct: 112 GVGTKLKLAFETGIHDTIGIDLVAMSVNDIITSGAKPLFFLDYFATSRLDVDLAEKVIKG 171
Query: 122 LYKGAEEAGVAIVGGETAVMPDLI--NGYDLAGTAIGIVEKGKVITGERIRPGDSVIGIS 179
+ +G ++ A++GGETA MPD YDL+G A+GIV+K VI G+ I GD +IG+
Sbjct: 172 IVEGCRQSECALLGGETAEMPDFYAEGEYDLSGFAVGIVKKTSVINGKNIVAGDVLIGLP 231
Query: 180 SSGIHSNGLTLARKLLI-PKYGLDYEYEG--RKLWEWLLEPTRIYVRPILELINSVEVHG 236
SSG+HSNG +L R++L L G L + L+ PT IYV+ +L++I V G
Sbjct: 232 SSGVHSNGFSLVRRVLARSNLSLKDALPGGSSTLGDALMAPTVIYVKQVLDMIEKGGVKG 291
Query: 237 LAHITGGGLL-NLKRLTNYGF-------ELEMPPIEGIFKLIHENG-VPLDEMFRVFNMG 287
LAHITGGG N+ R+ G E+PP +FK I + G + EM R FN+G
Sbjct: 292 LAHITGGGFTDNIPRVFPDGLGAVIHTDAWELPP---LFKWIQQTGRIEDSEMRRTFNLG 348
Query: 288 VGFIVVVPQEEKEEAL-EILSRHYKSYELGNVTRELG 323
+G ++VV E L E+ + Y +Y +G V G
Sbjct: 349 IGMVMVVSPEAASRILEEVKNGDYVAYRVGEVVNGEG 385
>sp|P20772|PUR2_SCHPO BIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADE1 [INCLUDES:
PHOSPHORIBOSYLAMINE--GLYCINE LIGASE (GARS) (GLYCINAMIDE
RIBONUCLEOTIDE SYNTHETASE) (PHOSPHORIBOSYLGLYCINAMIDE
SYNTHETASE); PHOSPHORIBOSYLFORMYLGLYCINAMIDINE
CYCLO-LIGASE (AIRS) (PHOSPHORIBOSYL-AM>
>gi|82792|pir||S00652 ADE1 multifunctional protein -
fission yeast (Schizosaccharomyces pombe)
>gi|4904|emb|CAA29820.1| (X06601) GARSase/AIRSase (AA 1
- 788) [Schizosaccharomyces pombe]
>gi|2832882|emb|CAA16823.1| (AL021730) bifunctional
purine biosynthetic protein
ade1-includes:phosphoribosylamine--glycine ligase
[Schizosaccharomyces pombe]
Length = 788
Score = 205 bits (515), Expect = 8e-52
Identities = 126/343 (36%), Positives = 202/343 (58%), Gaps = 36/343 (10%)
Query: 1 MLTYAQAGVDEE---KTARALREIIRTARETFKLRKGKVGEPGDIGHYAALLD-----FG 52
+LTY +GV + + + +++++++ R + G DIG + + D +
Sbjct: 436 ILTYENSGVSVDNGNEFVQRIKDLVKSTR--------RPGADADIGGFGGIFDLKQAGWN 487
Query: 53 NFYLAMTTDGVGTKVLVAEAVGKFDTIGIDMIAMNVNDLLCVGAEPLALVDYFAVKEPNE 112
+ L TDGVG+K+L+A ++ K DT+GID++AMNVNDL+ GAEPL +DYFA +
Sbjct: 488 DPLLVSATDGVGSKLLIALSLNKHDTVGIDLVAMNVNDLVVQGAEPLIFLDYFATGSLDL 547
Query: 113 EVFKQVAKGLYKGAEEAGVAIVGGETAVMPDLING--YDLAGTAIGIVEKGKVI-TGERI 169
+V +G+ KG ++AG A+VGGET+ MP L + YD GT++G V + ++ E
Sbjct: 548 KVSTSFVEGVVKGCKQAGCALVGGETSEMPGLYHDGHYDANGTSVGAVSRDDILPKPESF 607
Query: 170 RPGDSVIGISSSGIHSNGLTLARKLLIPKYGLDYEY-------EGRKLWEWLLEPTRIYV 222
GD ++G++S G+HSNG +L RK++ +Y D EY + +L + LL PTRIYV
Sbjct: 608 SKGDILLGLASDGVHSNGYSLVRKIV--EYS-DLEYTSVCPWDKNVRLGDSLLIPTRIYV 664
Query: 223 RPILELINSVEVHGLAHITGGGLL-NLKRL----TNYGFELEMPPIEGIFKLIHENG-VP 276
+P+L +I V G+AHITGGGL+ N+ R+ N +++ + +FK + + G VP
Sbjct: 665 KPLLHVIRKNIVKGMAHITGGGLVENVPRMLPSHLNAIIDVDTWEVPEVFKWLKDAGNVP 724
Query: 277 LDEMFRVFNMGVGFIVVVPQEEKEEAL-EILSRHYKSYELGNV 318
+ +M R FNMG+G +V V E+ EE + E+ S Y +G +
Sbjct: 725 ISDMARTFNMGIGMVVAVASEDAEETMKELTSVGETVYRIGQL 767
>pir||A83529 phosphoribosylaminoimidazole synthetase PA0945 [imported] -
Pseudomonas aeruginosa (strain PAO1)
>gi|9946850|gb|AAG04334.1|AE004528_12 (AE004528)
phosphoribosylaminoimidazole synthetase [Pseudomonas
aeruginosa]
Length = 353
Score = 205 bits (515), Expect = 8e-52
Identities = 131/321 (40%), Positives = 185/321 (56%), Gaps = 22/321 (6%)
Query: 2 LTYAQAGVDEEKTARALREIIRTARETFKLRKGKVGEPGDIGHYAALLDFGNFY----LA 57
L+Y AGVD + + I A+ T + G +G + AL + Y L
Sbjct: 8 LSYKDAGVDIDAGEALVERIKGVAKRT-----ARPEVMGGLGGFGALCEIPAGYKQPVLV 62
Query: 58 MTTDGVGTKVLVAEAVGKFDTIGIDMIAMNVNDLLCVGAEPLALVDYFAVKEPNEEVFKQ 117
TDGVGTK+ +A + K D+IG D++AM VNDL+ GAEPL +DY+A + N +V
Sbjct: 63 SGTDGVGTKLRLALNLNKHDSIGQDLVAMCVNDLVVCGAEPLFFLDYYATGKLNVDVAAT 122
Query: 118 VAKGLYKGAEEAGVAIVGGETAVMPDLING--YDLAGTAIGIVEKGKVITGERIRPGDSV 175
V G+ G E AG ++VGGETA MP + G YDLAG +G+VEK ++I G R++ GD++
Sbjct: 123 VVTGIGAGCELAGCSLVGGETAEMPGMYEGEDYDLAGFCVGVVEKAEIIDGSRVQAGDAL 182
Query: 176 IGISSSGIHSNGLTLARKLLIPKYGLD---YEYEGRKLWEWLLEPTRIYVRPILELINSV 232
I + SSG HSNG +L RK +I G D + +G+ L + L+ PTRIYV+P+L+LI
Sbjct: 183 IALPSSGPHSNGYSLIRK-IIEVSGADIAQVQLDGKPLADLLMAPTRIYVKPLLQLIKQT 241
Query: 233 -EVHGLAHITGGGLL-NLKRLTNYGFELEMPPIE----GIFKLIHENG-VPLDEMFRVFN 285
V +AHITGGGLL N+ R+ + + +F + E G V EM RV N
Sbjct: 242 GAVKAMAHITGGGLLDNIPRVLPDNAQAVIDVASWNRPAVFDWLQEQGNVDETEMHRVLN 301
Query: 286 MGVGFIVVVPQEEKEEALEIL 306
GVG ++ V Q + E+ALE+L
Sbjct: 302 CGVGMVICVAQSDAEKALEVL 322
>pir||F82103 phosphoribosylformylglycinamidine cyclo-ligase VC2226 [imported] -
Vibrio cholerae (group O1 strain N16961)
>gi|9656784|gb|AAF95370.1| (AE004294)
phosphoribosylformylglycinamidine cyclo-ligase [Vibrio
cholerae]
Length = 346
Score = 204 bits (513), Expect = 1e-51
Identities = 126/320 (39%), Positives = 193/320 (59%), Gaps = 22/320 (6%)
Query: 2 LTYAQAGVDEEKTARALREIIRTARETFKLRKGKVGEPGDIGHYAALLDFGNFY----LA 57
L+Y AGVD + AL E I+ A + + R+ +V G +G + AL + Y L
Sbjct: 8 LSYKDAGVDID-AGNALVERIKGAVK--RTRRPEV--MGGLGGFGALCELPTKYKHPVLV 62
Query: 58 MTTDGVGTKVLVAEAVGKFDTIGIDMIAMNVNDLLCVGAEPLALVDYFAVKEPNEEVFKQ 117
TDGVGTK+ +A + K DTIGID++AM VNDL+ GAEPL +DY+A + + + +
Sbjct: 63 SGTDGVGTKLRLALDMKKHDTIGIDLVAMCVNDLIVQGAEPLFFLDYYATGKLDVDTAAE 122
Query: 118 VAKGLYKGAEEAGVAIVGGETAVMPDLING--YDLAGTAIGIVEKGKVITGERIRPGDSV 175
V G+ G +AG A++GGETA MP + G YD+AG +G+VEK ++I G +++ GD++
Sbjct: 123 VISGIADGCLQAGCALIGGETAEMPGMYEGEDYDVAGFCVGVVEKEEIIDGSKVQVGDAL 182
Query: 176 IGISSSGIHSNGLTLARKLL-IPKYGLDYEYEGRKLWEWLLEPTRIYVRPILELINSVEV 234
I + SSG HSNG +L RK+L + K + G+ + E LL PT+IY++ L+LI ++
Sbjct: 183 IAVGSSGPHSNGYSLVRKILEVSKADKNERLAGKTIGEHLLAPTKIYIKSGLKLIAEHDI 242
Query: 235 HGLAHITGGGLL-NLKRLTNYGFELEMP------PIEGIFKLIHENG-VPLDEMFRVFNM 286
H ++HITGGG N+ R+ G + + P+ IF+ + E G V EM+R FN
Sbjct: 243 HAISHITGGGFWENIPRVLPEGTKAVIDGKSWEWPV--IFQWLQEKGNVTTHEMYRTFNC 300
Query: 287 GVGFIVVVPQEEKEEALEIL 306
GVG I+ +P+++ A+ +L
Sbjct: 301 GVGLIIALPKDQANAAVALL 320
>gb|AAC16901.1| (AF016634) phosphoribosylformylglycinamide cyclo-ligase
[Lactococcus lactis subsp. cremoris]
Length = 340
Score = 203 bits (511), Expect = 2e-51
Identities = 131/345 (37%), Positives = 197/345 (56%), Gaps = 33/345 (9%)
Query: 4 YAQAGVDEEKTARALREIIRTARETFKLRKGKVGEPGDIGHY--AALLDFGNFYLAMTTD 61
YA++GVD E + I + +T +L G +G G G ++LD L TD
Sbjct: 8 YAKSGVDVEAGYEVVSRIKKHVAKTERL--GVLGALGGFGGSFDLSVLDVKEPVLISGTD 65
Query: 62 GVGTKVLVAEAVGKFDTIGIDMIAMNVNDLLCVGAEPLALVDYFAVKEPNEEVFKQVAKG 121
GVGTK+++A K DTIGID +AM VND++ GAEPL +DY A + E +QV G
Sbjct: 66 GVGTKLMLAIRADKHDTIGIDCVAMCVNDIIAAGAEPLYFLDYIATGKNIPEKLEQVVAG 125
Query: 122 LYKGAEEAGVAIVGGETAVMPDLI--NGYDLAGTAIGIVEKGKVITGER-IRPGDSVIGI 178
+ +G +AG A++GGETA MP + + YDLAG A+G+ EK ++I GE+ + GD ++G+
Sbjct: 126 VAEGCLQAGAALIGGETAEMPGMYDEDDYDLAGFAVGVAEKSQLIDGEKDVEAGDVLLGL 185
Query: 179 SSSGIHSNGLTLARKLLIPKYGLDYEYE------GRKLWEWLLEPTRIYVRPILELINSV 232
+SSGIHSNG +L RK+ D++ + L + LL PT+IYV+ +L LI
Sbjct: 186 ASSGIHSNGYSLVRKVF-----ADFDLNESLPELDQSLIDTLLTPTKIYVKELLPLIKQN 240
Query: 233 EVHGLAHITGGGL-LNLKRLTNYGFELEMPPIEG------IFKLIHENG-VPLDEMFRVF 284
++ G+AHITGGG NL R+ +G L +EG IFK + + G + +EM+ +F
Sbjct: 241 KIKGIAHITGGGFHENLPRM--FGNSLSAEIVEGSWDVLPIFKALEKYGSIKHEEMYEIF 298
Query: 285 NMGVGFIVVVPQEEKEEALEILSRHYKSYELGN-VTRELGKIKVK 328
NMG+G ++ V E L + ++E+G V R+ + +K
Sbjct: 299 NMGIGMVIAVAPEN----AAALKKELNAFEIGQMVNRQEAPVVIK 339
>gb|AAG14579.1|AF293165_1 (AF293165) phosphoribosylaminoimidazole synthetase [Escherichia
coli]
Length = 350
Score = 202 bits (509), Expect = 4e-51
Identities = 132/343 (38%), Positives = 196/343 (56%), Gaps = 27/343 (7%)
Query: 2 LTYAQAGVDEEKTARALREIIRTARETFKLRKGKVGEPGDIGHYAALLDFGNFY----LA 57
L+Y AGVD + + I ++T R+ +V G +G + AL Y L
Sbjct: 12 LSYKDAGVDIDAGNALVGRIKGVVKKT---RRPEV--MGGLGGFGALCALPQKYREPVLV 66
Query: 58 MTTDGVGTKVLVAEAVGKFDTIGIDMIAMNVNDLLCVGAEPLALVDYFAVKEPNEEVFKQ 117
TDGVGTK+ +A + + DTIGID++AM VNDL+ GAEPL +DY+A + + +
Sbjct: 67 SGTDGVGTKLRLAMDLKRHDTIGIDLVAMCVNDLVVQGAEPLFFLDYYATGKLDVDTASA 126
Query: 118 VAKGLYKGAEEAGVAIVGGETAVMPDLING--YDLAGTAIGIVEKGKVITGERIRPGDSV 175
V G+ +G ++G ++VGGETA MP + +G YD+AG +G+VEK ++I G ++ GD +
Sbjct: 127 VISGIAEGCLQSGCSLVGGETAEMPGMYHGEDYDVAGFCVGVVEKSEIIDGSKVSDGDVL 186
Query: 176 IGISSSGIHSNGLTLARKLLIPKYGLD---YEYEGRKLWEWLLEPTRIYVRPILELINSV 232
I + SSG HSNG +L RK+L G D E +G+ L + LL PTRIYV+ +LELI V
Sbjct: 187 IALGSSGPHSNGYSLVRKIL-EVSGCDPQTTELDGKPLADHLLAPTRIYVKSVLELIEKV 245
Query: 233 EVHGLAHITGGGLL-NLKRL----TNYGFELEMPPIEGIFKLIHENG-VPLDEMFRVFNM 286
+VH +AH+TGGG N+ R+ T + +F + G V EM+R FN
Sbjct: 246 DVHAIAHLTGGGFWENIPRVLPDNTQAVIDESSWQWPEVFNWLQTAGNVERHEMYRTFNC 305
Query: 287 GVGFIVVVPQEEKEEALEILSRHYKSYELGNVTRELGKIKVKN 329
GVG I+ +P E ++AL +L+ + G T ++G IK +
Sbjct: 306 GVGMIIALPAPEVDKALALLNAN------GENTWKIGIIKASD 342
>gi|4503915 phosphoribosylglycinamide formyltransferase,
phosphoribosylglycinamide synthetase,
phosphoribosylaminoimidazole synthetase;
phosphoribosylglycinamide formyltransferase [Homo
sapiens] >gi|11526207|ref|XP_009737.1|
phosphoribosylglycinamide formyltransferase,
phosphoribosylglycinamide synthetase,
phosphoribosylaminoimidazole synthetase [Homo sapiens]
>gi|131616|sp|P22102|PUR2_HUMAN TRIFUNCTIONAL PURINE
BIOSYNTHETIC PROTEIN ADENOSINE-3 [INCLUDES:
PHOSPHORIBOSYLAMINE--GLYCINE LIGASE (GARS) (GLYCINAMIDE
RIBONUCLEOTIDE SYNTHETASE) (PHOSPHORIBOSYLGLYCINAMIDE
SYNTHETASE); PHOSPHORIBOSYLFORMYLGLYCINAMIDINE
CYCLO-LIGASE (AIRS) (PHOSPHORI> >gi|68647|pir||AJHUPR
purine synthesis multifunctional protein - human
>gi|31642|emb|CAA38119.1| (X54199) glycinamide
ribonucleotide synthetase-aminoimidazole ribonucleotide
synthetase-glycinamide ribonucleotide transformylase
[Homo sapiens]
Length = 1010
Score = 202 bits (508), Expect = 6e-51
Identities = 137/352 (38%), Positives = 202/352 (56%), Gaps = 30/352 (8%)
Query: 2 LTYAQAGVDEEKTARALREIIRTARETFKLRKGKVGEPGDIGHYAALLD-----FGNFYL 56
LTY ++GVD +++I A+ T + G D+G +A L D F + L
Sbjct: 435 LTYKESGVDIAAGNMLVKKIQPLAKAT-----SRSGCKVDLGGFAGLFDLKAAGFKDPLL 489
Query: 57 AMTTDGVGTKVLVAEAVGKFDTIGIDMIAMNVNDLLCVGAEPLALVDYFAVKEPNEEVFK 116
A TDGVGTK+ +A+ K DTIG D++AM VND+L GAEPL +DYF+ + + V +
Sbjct: 490 ASGTDGVGTKLKIAQLCNKHDTIGQDLVAMCVNDILAQGAEPLFFLDYFSCGKLDLSVTE 549
Query: 117 QVAKGLYKGAEEAGVAIVGGETAVMPDLI--NGYDLAGTAIGIVEKGKVITG-ERIRPGD 173
V G+ K +AG A++GGETA MPD+ YDLAG A+G +E+ + + ERI GD
Sbjct: 550 AVVAGIAKACGKAGCALLGGETAEMPDMYPPGEYDLAGFAVGAMERDQKLPHLERITEGD 609
Query: 174 SVIGISSSGIHSNGLTLARKLLIPKYGLDYEYEG------RKLWEWLLEPTRIYVRPILE 227
V+GI+SSG+HSNG +L RK ++ K L Y + L + LL PTRIY +L
Sbjct: 610 VVVGIASSGLHSNGFSLVRK-IVAKSSLQYSSPAPDGCGDQTLGDLLLTPTRIYSHSLLP 668
Query: 228 LINSVEVHGLAHITGGGLL-NLKRL--TNYGFELEMPP--IEGIFKLIHENG-VPLDEMF 281
++ S V AHITGGGLL N+ R+ G +L+ I +F + + G + +EM
Sbjct: 669 VLRSGHVKAFAHITGGGLLENIPRVLPEKLGVDLDAQTWRIPRVFSWLQQEGHLSEEEMA 728
Query: 282 RVFNMGVGFIVVVPQEEKEEALEILSRH-YKSYELGNVTREL---GKIKVKN 329
R FN GVG ++VV +E+ E+ L + +H +++ +G+V ++KVKN
Sbjct: 729 RTFNCGVGAVLVVSKEQTEQILRDIQQHKEEAWVIGSVVARAEGSPRVKVKN 780
>gb|AAB08890.1| (U68765) 5'-phosphoribosyl-5-aminoimidazole synthetase [Salmonella
typhimurium]
Length = 345
Score = 201 bits (507), Expect = 7e-51
Identities = 132/343 (38%), Positives = 195/343 (56%), Gaps = 27/343 (7%)
Query: 2 LTYAQAGVDEEKTARALREIIRTARETFKLRKGKVGEPGDIGHYAALLDFGNFY----LA 57
L+Y AGVD + + I ++T R+ +V G +G + AL Y L
Sbjct: 7 LSYKDAGVDIDAGNALVDRIKGVVKKT---RRPEV--MGGLGGFGALCALPQKYREPVLV 61
Query: 58 MTTDGVGTKVLVAEAVGKFDTIGIDMIAMNVNDLLCVGAEPLALVDYFAVKEPNEEVFKQ 117
TDGVGTK+ +A + + D IGID++AM VNDL+ GAEPL +DY+A + + +
Sbjct: 62 SGTDGVGTKLRLAMDLKRHDAIGIDLVAMCVNDLVVQGAEPLFFLDYYATGKLDVDTAAS 121
Query: 118 VAKGLYKGAEEAGVAIVGGETAVMPDLING--YDLAGTAIGIVEKGKVITGERIRPGDSV 175
V G+ +G ++G A+VGGETA MP + +G YD+AG +G+VEK ++I G R+ GD +
Sbjct: 122 VINGIAEGCLQSGCALVGGETAEMPGMYHGEDYDVAGFCVGVVEKSEIIDGSRVAEGDVL 181
Query: 176 IGISSSGIHSNGLTLARKLLIPKYGLDYE---YEGRKLWEWLLEPTRIYVRPILELINSV 232
I + SSG HSNG +L RK +I G D + EG+ L + LLEPTRIYV+ +LELI +V
Sbjct: 182 IALGSSGPHSNGYSLVRK-IIDVSGCDPQTTLLEGKPLADHLLEPTRIYVKSVLELIENV 240
Query: 233 EVHGLAHITGGGLL-NLKRLTNYGFELEMPPIE----GIFKLIHENG-VPLDEMFRVFNM 286
+VH +AH+TGGG N+ R+ + + IF + G V EM+R FN
Sbjct: 241 DVHAIAHLTGGGFWENIPRVLPENTQAVINESSWQWPAIFTWLQTAGNVSRHEMYRTFNC 300
Query: 287 GVGFIVVVPQEEKEEALEILSRHYKSYELGNVTRELGKIKVKN 329
GVG ++ + E ++AL +L+ E G ++G IK +
Sbjct: 301 GVGMVIALSAPEADKALALLN------EKGENAWKIGIIKASD 337
>gb|AAD00110.1| (U64826) phosphoribosyl aminoimidazole synthetase [Streptomyces
lividans] >gi|5918489|emb|CAB56367.1| (AL118514)
phosphoribosylformylglycinamidine cyclo-ligase
[Streptomyces coelicolor A3(2)]
Length = 355
Score = 201 bits (507), Expect = 7e-51
Identities = 131/333 (39%), Positives = 192/333 (57%), Gaps = 18/333 (5%)
Query: 3 TYAQAGVDEEKTARA---LREIIRTARETFKLRKGKVGEPGDIGHYAALLDFGNFYLAMT 59
+YA AGVD E RA ++E ++ R L G +G + +AL ++ LA
Sbjct: 8 SYAAAGVDIEAGDRAVELMKEWVKKTRRPEVL--GGLGGFAGLFDASALKNYERPLLASA 65
Query: 60 TDGVGTKVLVAEAVGKFDTIGIDMIAMNVNDLLCVGAEPLALVDYFAVKEPNEEVFKQVA 119
TDGVGTKV +A +G +DTIG D++AM ++D++ GAEPL + DY V + + E +
Sbjct: 66 TDGVGTKVDIARQLGVYDTIGHDLVAMVMDDIVVCGAEPLFMTDYICVGKVHPERVAAIV 125
Query: 120 KGLYKGAEEAGVAIVGGETAVMPDLI--NGYDLAGTAIGIVEKGKVITGERIRPGDSVIG 177
KG+ +G AG A+VGGETA P L+ + +D+AG G+VE +++ +RIR GD+VI
Sbjct: 126 KGIAEGCVLAGCALVGGETAEHPGLLGADDFDVAGAGTGVVEADRLLGPDRIRTGDAVIA 185
Query: 178 ISSSGIHSNGLTLARKLLIPKYGLDYEYE----GRKLWEWLLEPTRIYVRPILELINSVE 233
++SSG+HSNG +L R +L+ + GL + GR L E LLEPT+IY L L+ + E
Sbjct: 186 MASSGLHSNGYSLVRHVLLNEGGLALDAHLDGLGRTLGEELLEPTKIYSLDCLALMRTAE 245
Query: 234 VHGLAHITGGGL-LNLKRLTNYGFELEMPPIE----GIFKLIHENG-VPLDEMFRVFNMG 287
VH +H+TGGGL NL R+ G + IF L+ G V E+ + NMG
Sbjct: 246 VHAFSHVTGGGLAANLARVIPDGLHAVVDRSTWTPGAIFDLVGRTGKVERLELEKTLNMG 305
Query: 288 VGFIVVVPQEEKEEALEILS-RHYKSYELGNVT 319
VG I +VP+E + AL L+ R ++ G +T
Sbjct: 306 VGMIAIVPEESTDVALTALADRGVDAWVAGEIT 338
>gb|AAG14633.1|AF293192_1 (AF293192) phosphoribosylaminoimidazole synthetase [Escherichia
coli]
Length = 350
Score = 201 bits (506), Expect = 1e-50
Identities = 127/321 (39%), Positives = 188/321 (58%), Gaps = 21/321 (6%)
Query: 2 LTYAQAGVDEEKTARALREIIRTARETFKLRKGKVGEPGDIGHYAALLDFGNFY----LA 57
L+Y AGVD + + I ++T R+ +V G +G + AL Y L
Sbjct: 12 LSYKDAGVDIDAGNALVGRIKGVVKKT---RRPEV--MGGLGGFGALCALPQKYREPVLV 66
Query: 58 MTTDGVGTKVLVAEAVGKFDTIGIDMIAMNVNDLLCVGAEPLALVDYFAVKEPNEEVFKQ 117
TDGVGTK+ +A + + DTIGID++AM VNDL+ GAEPL +DY+A + + +
Sbjct: 67 SGTDGVGTKLRLAMDLKRHDTIGIDLVAMCVNDLVVQGAEPLFFLDYYATGKLDVDTASA 126
Query: 118 VAKGLYKGAEEAGVAIVGGETAVMPDLING--YDLAGTAIGIVEKGKVITGERIRPGDSV 175
V G+ +G ++G ++VGGETA MP + +G YD+AG +G+VEK ++I G ++ GD +
Sbjct: 127 VISGIAEGCLQSGCSLVGGETAEMPGMYHGEDYDVAGFCVGVVEKSEIIDGSKVSDGDVL 186
Query: 176 IGISSSGIHSNGLTLARKLLIPKYGLD---YEYEGRKLWEWLLEPTRIYVRPILELINSV 232
I + SSG HSNG +L RK+L G D E +G+ L + LL PTRIYV+ +LELI V
Sbjct: 187 IALGSSGPHSNGYSLVRKIL-EVSGCDPQTTELDGKPLADHLLAPTRIYVKSVLELIEKV 245
Query: 233 EVHGLAHITGGGLL-NLKRL----TNYGFELEMPPIEGIFKLIHENG-VPLDEMFRVFNM 286
+VH +AH+TGGG N+ R+ T+ + +F + G V EM+R FN
Sbjct: 246 DVHAIAHLTGGGFWENIPRVLPDNTHAVIDESSWQWPEVFNWLQTAGNVERHEMYRTFNC 305
Query: 287 GVGFIVVVPQEEKEEALEILS 307
GVG I+ +P E ++AL +L+
Sbjct: 306 GVGMIIALPAPEVDKALALLN 326
>gb|AAG14663.1|AF293207_1 (AF293207) phosphoribosylaminoimidazole synthetase [Escherichia
coli] >gi|10186151|gb|AAG14665.1|AF293208_1 (AF293208)
phosphoribosylaminoimidazole synthetase [Escherichia
coli]
Length = 350
Score = 201 bits (505), Expect = 1e-50
Identities = 127/321 (39%), Positives = 187/321 (57%), Gaps = 21/321 (6%)
Query: 2 LTYAQAGVDEEKTARALREIIRTARETFKLRKGKVGEPGDIGHYAALLDFGNFY----LA 57
L+Y AGVD + + I ++T R+ +V G +G + AL Y L
Sbjct: 12 LSYKDAGVDIDAGNALVGRIKGVVKKT---RRPEV--MGGLGGFGALCALPQKYREPVLV 66
Query: 58 MTTDGVGTKVLVAEAVGKFDTIGIDMIAMNVNDLLCVGAEPLALVDYFAVKEPNEEVFKQ 117
TDGVGTK+ +A + + DTIGID++AM VNDL+ GAEPL +DY+A + + +
Sbjct: 67 SGTDGVGTKLRLAMDLKRHDTIGIDLVAMCVNDLVVQGAEPLFFLDYYATGKLDVDTTSA 126
Query: 118 VAKGLYKGAEEAGVAIVGGETAVMPDLING--YDLAGTAIGIVEKGKVITGERIRPGDSV 175
V G+ +G ++G ++VGGETA MP + +G YD+AG +G+VEK ++I G ++ GD +
Sbjct: 127 VISGIAEGCLQSGCSLVGGETAEMPGMYHGEDYDVAGFCVGVVEKSEIIDGSKVSDGDVL 186
Query: 176 IGISSSGIHSNGLTLARKLLIPKYGLD---YEYEGRKLWEWLLEPTRIYVRPILELINSV 232
I + SSG HSNG +L RK+L G D E +G+ L + LL PTRIYV+ +LELI V
Sbjct: 187 IALGSSGPHSNGYSLVRKIL-EVSGCDPQTTELDGKPLADHLLAPTRIYVKSVLELIEKV 245
Query: 233 EVHGLAHITGGGLL-NLKRL----TNYGFELEMPPIEGIFKLIHENG-VPLDEMFRVFNM 286
+VH +AH+TGGG N+ R+ T + +F + G V EM+R FN
Sbjct: 246 DVHAIAHLTGGGFWENIPRVLPDNTQAVIDESSWQWPEVFNWLQTAGNVERHEMYRTFNC 305
Query: 287 GVGFIVVVPQEEKEEALEILS 307
GVG I+ +P E ++AL +L+
Sbjct: 306 GVGMIIALPAPEVDKALALLN 326
>gb|AAG14569.1|AF293160_1 (AF293160) phosphoribosylaminoimidazole synthetase [Escherichia
coli] >gi|10186010|gb|AAG14571.1|AF293161_1 (AF293161)
phosphoribosylaminoimidazole synthetase [Escherichia
coli] >gi|10186013|gb|AAG14573.1|AF293162_1 (AF293162)
phosphoribosylaminoimidazole synthetase [Escherichia
coli] >gi|10186016|gb|AAG14575.1|AF293163_1 (AF293163)
phosphoribosylaminoimidazole synthetase [Escherichia
coli] >gi|10186037|gb|AAG14589.1|AF293170_1 (AF293170)
phosphoribosylaminoimidazole synthetase [Escherichia
coli] >gi|10186040|gb|AAG14591.1|AF293171_1 (AF293171)
phosphoribosylaminoimidazole synthetase [Escherichia
coli] >gi|10186043|gb|AAG14593.1|AF293172_1 (AF293172)
phosphoribosylaminoimidazole synthetase [Escherichia
coli] >gi|10186046|gb|AAG14595.1|AF293173_1 (AF293173)
phosphoribosylaminoimidazole synthetase [Escherichia
coli] >gi|10186049|gb|AAG14597.1|AF293174_1 (AF293174)
phosphoribosylaminoimidazole synthetase [Escherichia
coli] >gi|10186052|gb|AAG14599.1|AF293175_1 (AF293175)
phosphoribosylaminoimidazole synthetase [Escherichia
coli] >gi|10186055|gb|AAG14601.1|AF293176_1 (AF293176)
phosphoribosylaminoimidazole synthetase [Escherichia
coli] >gi|10186058|gb|AAG14603.1|AF293177_1 (AF293177)
phosphoribosylaminoimidazole synthetase [Escherichia
coli] >gi|10186061|gb|AAG14605.1|AF293178_1 (AF293178)
phosphoribosylaminoimidazole synthetase [Escherichia
coli] >gi|10186064|gb|AAG14607.1|AF293179_1 (AF293179)
phosphoribosylaminoimidazole synthetase [Escherichia
coli] >gi|10186067|gb|AAG14609.1|AF293180_1 (AF293180)
phosphoribosylaminoimidazole synthetase [Escherichia
coli] >gi|10186070|gb|AAG14611.1|AF293181_1 (AF293181)
phosphoribosylaminoimidazole synthetase [Escherichia
coli] >gi|10186073|gb|AAG14613.1|AF293182_1 (AF293182)
phosphoribosylaminoimidazole synthetase [Escherichia
coli] >gi|10186076|gb|AAG14615.1|AF293183_1 (AF293183)
phosphoribosylaminoimidazole synthetase [Escherichia
coli] >gi|10186079|gb|AAG14617.1|AF293184_1 (AF293184)
phosphoribosylaminoimidazole synthetase [Escherichia
coli] >gi|10186082|gb|AAG14619.1|AF293185_1 (AF293185)
phosphoribosylaminoimidazole synthetase [Escherichia
coli] >gi|10186085|gb|AAG14621.1|AF293186_1 (AF293186)
phosphoribosylaminoimidazole synthetase [Escherichia
coli] >gi|10186088|gb|AAG14623.1|AF293187_1 (AF293187)
phosphoribosylaminoimidazole synthetase [Escherichia
coli] >gi|10186091|gb|AAG14625.1|AF293188_1 (AF293188)
phosphoribosylaminoimidazole synthetase [Escherichia
coli] >gi|10186094|gb|AAG14627.1|AF293189_1 (AF293189)
phosphoribosylaminoimidazole synthetase [Escherichia
coli] >gi|10186097|gb|AAG14629.1|AF293190_1 (AF293190)
phosphoribosylaminoimidazole synthetase [Escherichia
coli] >gi|10186100|gb|AAG14631.1|AF293191_1 (AF293191)
phosphoribosylaminoimidazole synthetase [Escherichia
coli] >gi|10186106|gb|AAG14635.1|AF293193_1 (AF293193)
phosphoribosylaminoimidazole synthetase [Escherichia
coli] >gi|10186109|gb|AAG14637.1|AF293194_1 (AF293194)
phosphoribosylaminoimidazole synthetase [Escherichia
coli] >gi|10186112|gb|AAG14639.1|AF293195_1 (AF293195)
phosphoribosylaminoimidazole synthetase [Escherichia
coli] >gi|10186115|gb|AAG14641.1|AF293196_1 (AF293196)
phosphoribosylaminoimidazole synthetase [Escherichia
coli] >gi|10186118|gb|AAG14643.1|AF293197_1 (AF293197)
phosphoribosylaminoimidazole synthetase [Escherichia
coli] >gi|10186121|gb|AAG14645.1|AF293198_1 (AF293198)
phosphoribosylaminoimidazole synthetase [Escherichia
coli] >gi|10186124|gb|AAG14647.1|AF293199_1 (AF293199)
phosphoribosylaminoimidazole synthetase [Escherichia
coli] >gi|10186127|gb|AAG14649.1|AF293200_1 (AF293200)
phosphoribosylaminoimidazole synthetase [Escherichia
coli] >gi|10186130|gb|AAG14651.1|AF293201_1 (AF293201)
phosphoribosylaminoimidazole synthetase [Escherichia
coli] >gi|10186133|gb|AAG14653.1|AF293202_1 (AF293202)
phosphoribosylaminoimidazole synthetase [Escherichia
coli] >gi|10186139|gb|AAG14657.1|AF293204_1 (AF293204)
phosphoribosylaminoimidazole synthetase [Escherichia
coli] >gi|10186142|gb|AAG14659.1|AF293205_1 (AF293205)
phosphoribosylaminoimidazole synthetase [Escherichia
coli] >gi|10186145|gb|AAG14661.1|AF293206_1 (AF293206)
phosphoribosylaminoimidazole synthetase [Escherichia
coli] >gi|10186154|gb|AAG14667.1|AF293209_1 (AF293209)
phosphoribosylaminoimidazole synthetase [Escherichia
coli] >gi|10186157|gb|AAG14669.1|AF293210_1 (AF293210)
phosphoribosylaminoimidazole synthetase [Escherichia
coli] >gi|10186160|gb|AAG14671.1|AF293211_1 (AF293211)
phosphoribosylaminoimidazole synthetase [Escherichia
coli] >gi|10186163|gb|AAG14673.1|AF293212_1 (AF293212)
phosphoribosylaminoimidazole synthetase [Escherichia
coli]
Length = 350
Score = 201 bits (505), Expect = 1e-50
Identities = 127/321 (39%), Positives = 187/321 (57%), Gaps = 21/321 (6%)
Query: 2 LTYAQAGVDEEKTARALREIIRTARETFKLRKGKVGEPGDIGHYAALLDFGNFY----LA 57
L+Y AGVD + + I ++T R+ +V G +G + AL Y L
Sbjct: 12 LSYKDAGVDIDAGNALVGRIKGVVKKT---RRPEV--MGGLGGFGALCALPQKYREPVLV 66
Query: 58 MTTDGVGTKVLVAEAVGKFDTIGIDMIAMNVNDLLCVGAEPLALVDYFAVKEPNEEVFKQ 117
TDGVGTK+ +A + + DTIGID++AM VNDL+ GAEPL +DY+A + + +
Sbjct: 67 SGTDGVGTKLRLAMDLKRHDTIGIDLVAMCVNDLVVQGAEPLFFLDYYATGKLDVDTASA 126
Query: 118 VAKGLYKGAEEAGVAIVGGETAVMPDLING--YDLAGTAIGIVEKGKVITGERIRPGDSV 175
V G+ +G ++G ++VGGETA MP + +G YD+AG +G+VEK ++I G ++ GD +
Sbjct: 127 VISGIAEGCLQSGCSLVGGETAEMPGMYHGEDYDVAGFCVGVVEKSEIIDGSKVSDGDVL 186
Query: 176 IGISSSGIHSNGLTLARKLLIPKYGLD---YEYEGRKLWEWLLEPTRIYVRPILELINSV 232
I + SSG HSNG +L RK+L G D E +G+ L + LL PTRIYV+ +LELI V
Sbjct: 187 IALGSSGPHSNGYSLVRKIL-EVSGCDPQTTELDGKPLADHLLAPTRIYVKSVLELIEKV 245
Query: 233 EVHGLAHITGGGLL-NLKRL----TNYGFELEMPPIEGIFKLIHENG-VPLDEMFRVFNM 286
+VH +AH+TGGG N+ R+ T + +F + G V EM+R FN
Sbjct: 246 DVHAIAHLTGGGFWENIPRVLPDNTQAVIDESSWQWPEVFNWLQTAGNVERHEMYRTFNC 305
Query: 287 GVGFIVVVPQEEKEEALEILS 307
GVG I+ +P E ++AL +L+
Sbjct: 306 GVGMIIALPAPEVDKALALLN 326
>gb|AAG14585.1|AF293168_1 (AF293168) phosphoribosylaminoimidazole synthetase [Escherichia
coli] >gi|10186034|gb|AAG14587.1|AF293169_1 (AF293169)
phosphoribosylaminoimidazole synthetase [Escherichia
coli]
Length = 350
Score = 201 bits (505), Expect = 1e-50
Identities = 127/321 (39%), Positives = 187/321 (57%), Gaps = 21/321 (6%)
Query: 2 LTYAQAGVDEEKTARALREIIRTARETFKLRKGKVGEPGDIGHYAALLDFGNFY----LA 57
L+Y AGVD + + I ++T R+ +V G +G + AL Y L
Sbjct: 12 LSYKDAGVDIDAGNALVGRIKGVVKKT---RRPEV--MGGLGGFGALCALPQKYREPVLV 66
Query: 58 MTTDGVGTKVLVAEAVGKFDTIGIDMIAMNVNDLLCVGAEPLALVDYFAVKEPNEEVFKQ 117
TDGVGTK+ +A + + DTIGID++AM VNDL+ GAEPL +DY+A + + +
Sbjct: 67 SGTDGVGTKLRLAMDLKRHDTIGIDLVAMCVNDLVVQGAEPLFFLDYYATGKLDVDTASA 126
Query: 118 VAKGLYKGAEEAGVAIVGGETAVMPDLING--YDLAGTAIGIVEKGKVITGERIRPGDSV 175
V G+ +G ++G ++VGGETA MP + +G YD+AG +G+VEK ++I G ++ GD +
Sbjct: 127 VISGIAEGCLQSGCSLVGGETAEMPGMYHGEDYDVAGFCVGVVEKSEIIDGSKVSDGDVL 186
Query: 176 IGISSSGIHSNGLTLARKLLIPKYGLD---YEYEGRKLWEWLLEPTRIYVRPILELINSV 232
I + SSG HSNG +L RK+L G D E +G+ L + LL PTRIYV+ +LELI V
Sbjct: 187 IALGSSGPHSNGYSLVRKIL-EVSGCDPQTTELDGKPLADHLLAPTRIYVKSVLELIEKV 245
Query: 233 EVHGLAHITGGGLL-NLKRL----TNYGFELEMPPIEGIFKLIHENG-VPLDEMFRVFNM 286
+VH +AH+TGGG N+ R+ T + +F + G V EM+R FN
Sbjct: 246 DVHAIAHLTGGGFWENIPRVLPDNTQAVIDESSWQWPEVFNWLQTAGNVERHEMYRTFNC 305
Query: 287 GVGFIVVVPQEEKEEALEILS 307
GVG I+ +P E ++AL +L+
Sbjct: 306 GVGMIIALPAPEVDKALALLN 326
>sp|P08178|PUR5_ECOLI PHOSPHORIBOSYLFORMYLGLYCINAMIDINE CYCLO-LIGASE (AIRS)
(PHOSPHORIBOSYL-AMINOIMIDAZOLE SYNTHETASE) (AIR
SYNTHASE) >gi|68627|pir||AJECPC
phosphoribosylformylglycinamidine cyclo-ligase (EC
6.3.3.1) - Escherichia coli >gi|147425|gb|AAA83898.1|
(M13747) 5'-phosphoribosyl-5-aminoimidazole synthetase
[Escherichia coli] >gi|1788845|gb|AAC75552.1| (AE000336)
phosphoribosylaminoimidazole synthetase = AIR synthetase
[Escherichia coli K12] >gi|1805559|dbj|BAA16387.1|
(D90878) PHOSPHORIBOSYLFORMYLGLYCINAMIDINE CYCLO-LIGASE
(EC 6.3.3.1) (AIRS) (PHOSPHORIBOSYL-AMINOIMIDAZOLE
SYNTHETASE) (AIR SYNTHASE). [Escherichia coli]
Length = 345
Score = 200 bits (504), Expect = 2e-50
Identities = 127/321 (39%), Positives = 187/321 (57%), Gaps = 21/321 (6%)
Query: 2 LTYAQAGVDEEKTARALREIIRTARETFKLRKGKVGEPGDIGHYAALLDFGNFY----LA 57
L+Y AGVD + + I ++T R+ +V G +G + AL Y L
Sbjct: 7 LSYKDAGVDIDAGNALVGRIKGVVKKT---RRPEV--MGGLGGFGALCALPQKYREPVLV 61
Query: 58 MTTDGVGTKVLVAEAVGKFDTIGIDMIAMNVNDLLCVGAEPLALVDYFAVKEPNEEVFKQ 117
TDGVGTK+ +A + + DTIGID++AM VNDL+ GAEPL +DY+A + + +
Sbjct: 62 SGTDGVGTKLRLAMDLKRHDTIGIDLVAMCVNDLVVQGAEPLFFLDYYATGKLDVDTASA 121
Query: 118 VAKGLYKGAEEAGVAIVGGETAVMPDLING--YDLAGTAIGIVEKGKVITGERIRPGDSV 175
V G+ +G ++G ++VGGETA MP + +G YD+AG +G+VEK ++I G ++ GD +
Sbjct: 122 VISGIAEGCLQSGCSLVGGETAEMPGMYHGEDYDVAGFCVGVVEKSEIIDGSKVSDGDVL 181
Query: 176 IGISSSGIHSNGLTLARKLLIPKYGLD---YEYEGRKLWEWLLEPTRIYVRPILELINSV 232
I + SSG HSNG +L RK+L G D E +G+ L + LL PTRIYV+ +LELI V
Sbjct: 182 IALGSSGPHSNGYSLVRKIL-EVSGCDPQTTELDGKPLADHLLAPTRIYVKSVLELIEKV 240
Query: 233 EVHGLAHITGGGLL-NLKRL----TNYGFELEMPPIEGIFKLIHENG-VPLDEMFRVFNM 286
+VH +AH+TGGG N+ R+ T + +F + G V EM+R FN
Sbjct: 241 DVHAIAHLTGGGFWENIPRVLPDNTQAVIDESSWQWPEVFNWLQTAGNVEHHEMYRTFNC 300
Query: 287 GVGFIVVVPQEEKEEALEILS 307
GVG I+ +P E ++AL +L+
Sbjct: 301 GVGMIIALPAPEVDKALALLN 321
>pdb|1CLI|A Chain A, X-Ray Crystal Structure Of Aminoimidazole Ribonucleotide
Synthetase (Purm), From The E. Coli Purine Biosynthetic
Pathway, At 2.5 A Resolution >gi|6137339|pdb|1CLI|C
Chain C, X-Ray Crystal Structure Of Aminoimidazole
Ribonucleotide Synthetase (Purm), From The E. Coli
Purine Biosynthetic Pathway, At 2.5 A Resolution
>gi|6137338|pdb|1CLI|B Chain B, X-Ray Crystal Structure
Of Aminoimidazole Ribonucleotide Synthetase (Purm), From
The E. Coli Purine Biosynthetic Pathway, At 2.5 A
Resolution >gi|6137340|pdb|1CLI|D Chain D, X-Ray Crystal
Structure Of Aminoimidazole Ribonucleotide Synthetase
(Purm), From The E. Coli Purine Biosynthetic Pathway, At
2.5 A Resolution
Length = 345
Score = 200 bits (504), Expect = 2e-50
Identities = 127/321 (39%), Positives = 187/321 (57%), Gaps = 21/321 (6%)
Query: 2 LTYAQAGVDEEKTARALREIIRTARETFKLRKGKVGEPGDIGHYAALLDFGNFY----LA 57
L+Y AGVD + + I ++T R+ +V G +G + AL Y L
Sbjct: 7 LSYKDAGVDIDAGNALVGRIKGVVKKT---RRPEV--MGGLGGFGALCALPQKYREPVLV 61
Query: 58 MTTDGVGTKVLVAEAVGKFDTIGIDMIAMNVNDLLCVGAEPLALVDYFAVKEPNEEVFKQ 117
TDGVGTK+ +A + + DTIGID++AM VNDL+ GAEPL +DY+A + + +
Sbjct: 62 SGTDGVGTKLRLAMDLKRHDTIGIDLVAMCVNDLVVQGAEPLFFLDYYATGKLDVDTASA 121
Query: 118 VAKGLYKGAEEAGVAIVGGETAVMPDLING--YDLAGTAIGIVEKGKVITGERIRPGDSV 175
V G+ +G ++G ++VGGETA MP + +G YD+AG +G+VEK ++I G ++ GD +
Sbjct: 122 VISGIAEGCLQSGCSLVGGETAEMPGMYHGEDYDVAGFCVGVVEKSEIIDGSKVSDGDVL 181
Query: 176 IGISSSGIHSNGLTLARKLLIPKYGLD---YEYEGRKLWEWLLEPTRIYVRPILELINSV 232
I + SSG HSNG +L RK+L G D E +G+ L + LL PTRIYV+ +LELI V
Sbjct: 182 IALGSSGPHSNGYSLVRKIL-EVSGCDPQTTELDGKPLADHLLAPTRIYVKSVLELIEKV 240
Query: 233 EVHGLAHITGGGLL-NLKRL----TNYGFELEMPPIEGIFKLIHENG-VPLDEMFRVFNM 286
+VH +AH+TGGG N+ R+ T + +F + G V EM+R FN
Sbjct: 241 DVHAIAHLTGGGFWENIPRVLPDNTQAVIDESSWQWPEVFNWLQTAGNVEHHEMYRTFNC 300
Query: 287 GVGFIVVVPQEEKEEALEILS 307
GVG I+ +P E ++AL +L+
Sbjct: 301 GVGMIIALPAPEVDKALALLN 321
>gb|AAG14583.1|AF293167_1 (AF293167) phosphoribosylaminoimidazole synthetase [Escherichia
coli]
Length = 350
Score = 200 bits (504), Expect = 2e-50
Identities = 127/321 (39%), Positives = 187/321 (57%), Gaps = 21/321 (6%)
Query: 2 LTYAQAGVDEEKTARALREIIRTARETFKLRKGKVGEPGDIGHYAALLDFGNFY----LA 57
L+Y AGVD + + I ++T R+ +V G +G + AL Y L
Sbjct: 12 LSYKDAGVDIDAGNALVGRIKGVVKKT---RRPEV--MGGLGGFGALCALPQKYREPVLV 66
Query: 58 MTTDGVGTKVLVAEAVGKFDTIGIDMIAMNVNDLLCVGAEPLALVDYFAVKEPNEEVFKQ 117
TDGVGTK+ +A + + DTIGID++AM VNDL+ GAEPL +DY+A + + +
Sbjct: 67 SGTDGVGTKLRLAMDLKRHDTIGIDLVAMCVNDLVVQGAEPLFFLDYYATGKLDVDTASA 126
Query: 118 VAKGLYKGAEEAGVAIVGGETAVMPDLING--YDLAGTAIGIVEKGKVITGERIRPGDSV 175
V G+ +G ++G ++VGGETA MP + +G YD+AG +G+VEK ++I G ++ GD +
Sbjct: 127 VISGIAEGCLQSGCSLVGGETAEMPGMYHGEDYDVAGFCVGVVEKSEIIDGSKVSDGDVL 186
Query: 176 IGISSSGIHSNGLTLARKLLIPKYGLD---YEYEGRKLWEWLLEPTRIYVRPILELINSV 232
I + SSG HSNG +L RK+L G D E +G+ L + LL PTRIYV+ +LELI V
Sbjct: 187 IALGSSGPHSNGYSLVRKIL-EVSGCDPQTTELDGKPLADHLLAPTRIYVKSVLELIEKV 245
Query: 233 EVHGLAHITGGGLL-NLKRL----TNYGFELEMPPIEGIFKLIHENG-VPLDEMFRVFNM 286
+VH +AH+TGGG N+ R+ T + +F + G V EM+R FN
Sbjct: 246 DVHAIAHLTGGGFWENIPRVLPDNTQAVIDESSWQWPEVFNWLQTAGNVEHHEMYRTFNC 305
Query: 287 GVGFIVVVPQEEKEEALEILS 307
GVG I+ +P E ++AL +L+
Sbjct: 306 GVGMIIALPAPEVDKALALLN 326
>sp|P21872|PUR2_CHICK TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADENOSINE-3 [INCLUDES:
PHOSPHORIBOSYLAMINE--GLYCINE LIGASE (GARS) (GLYCINAMIDE
RIBONUCLEOTIDE SYNTHETASE) (PHOSPHORIBOSYLGLYCINAMIDE
SYNTHETASE); PHOSPHORIBOSYLFORMYLGLYCINAMIDINE
CYCLO-LIGASE (AIRS) (PHOSPHORI> >gi|68648|pir||AJCHPR
purine synthesis multifunctional protein - chicken
>gi|62899|emb|CAA38120.1| (X54200) glycinamide
ribonucleotide synthetase-aminoimidazole ribonucleotide
synthetase-glycinamide ribonucleotide transformylase
[Gallus gallus]
Length = 1003
Score = 199 bits (502), Expect = 3e-50
Identities = 129/336 (38%), Positives = 197/336 (58%), Gaps = 25/336 (7%)
Query: 2 LTYAQAGVDEEKTARALREIIRTARETFKLRKGKVGEPGDIGHYAALLD-----FGNFYL 56
LTY +GVD +++I A T + G ++G +A L D + + L
Sbjct: 435 LTYKNSGVDIAAGNILVQKIKPLAAAT-----SRSGCNAELGGFAGLFDLKAAGYKDPIL 489
Query: 57 AMTTDGVGTKVLVAEAVGKFDTIGIDMIAMNVNDLLCVGAEPLALVDYFAVKEPNEEVFK 116
TDGVGTK+ +A+ K DTIG D++AM VND+L GAEPL +DYFA + + EV +
Sbjct: 490 VSGTDGVGTKLKIAQVCKKHDTIGQDLVAMCVNDILAQGAEPLFFLDYFACGKLDVEVAQ 549
Query: 117 QVAKGLYKGAEEAGVAIVGGETAVMPDLI--NGYDLAGTAIGIVEKGKVITG-ERIRPGD 173
V G+ + ++AG A++GGETA MP + YDLAG A+G VE+G+++ ERI GD
Sbjct: 550 GVIAGIAEACQKAGCALLGGETAEMPGMYPPGEYDLAGFAVGAVERGQMLPQLERIADGD 609
Query: 174 SVIGISSSGIHSNGLTLARKLLIPKYGLDYEYE-----GRKLWEWLLEPTRIYVRPILEL 228
VIG++SSG+HSNG +L R+ ++ K LD+ + + L + LL PT+IY + +L +
Sbjct: 610 VVIGVASSGVHSNGYSLVRR-IVEKSSLDFSSQVGVSGDQTLGDLLLTPTKIYSKTLLPV 668
Query: 229 INSVEVHGLAHITGGGLL-NLKRLTNYGFELEMP----PIEGIFKLIHENG-VPLDEMFR 282
+ S V AHITGGGLL N+ R+ F + + I IF +H+ G + +EM R
Sbjct: 669 LRSGHVKAYAHITGGGLLENIPRVLPDSFGVVLDALSWKIPEIFCWLHKEGNLSEEEMAR 728
Query: 283 VFNMGVGFIVVVPQEEKEEALEILSRHYKSYELGNV 318
FN G+G ++VV +E ++ L+ + +H ++ +G V
Sbjct: 729 TFNCGIGAVLVVQKELAQQVLKDVQKHEAAWLIGKV 764
>gb|AAG14577.1|AF293164_1 (AF293164) phosphoribosylaminoimidazole synthetase [Escherichia
coli]
Length = 350
Score = 199 bits (501), Expect = 4e-50
Identities = 126/321 (39%), Positives = 187/321 (58%), Gaps = 21/321 (6%)
Query: 2 LTYAQAGVDEEKTARALREIIRTARETFKLRKGKVGEPGDIGHYAALLDFGNFY----LA 57
L+Y AGVD + + I ++T R+ +V G +G + AL Y L
Sbjct: 12 LSYKDAGVDIDAGNALVGRIKGVVKKT---RRPEV--MGGLGGFGALCALPQKYREPVLV 66
Query: 58 MTTDGVGTKVLVAEAVGKFDTIGIDMIAMNVNDLLCVGAEPLALVDYFAVKEPNEEVFKQ 117
TDGVGTK+ +A + + DTIGID++AM VNDL+ GAEPL +DY+A + + +
Sbjct: 67 SGTDGVGTKLRLAMDLKRHDTIGIDLVAMCVNDLVVQGAEPLFFLDYYATGKLDVDTASA 126
Query: 118 VAKGLYKGAEEAGVAIVGGETAVMPDLING--YDLAGTAIGIVEKGKVITGERIRPGDSV 175
V G+ +G ++G ++VGGETA MP + +G YD+AG +G+VEK ++I G ++ GD +
Sbjct: 127 VISGIAEGCLQSGCSLVGGETAEMPGMYHGEDYDVAGFCVGVVEKSEIIDGSKVSDGDVL 186
Query: 176 IGISSSGIHSNGLTLARKLLIPKYGLD---YEYEGRKLWEWLLEPTRIYVRPILELINSV 232
I + SSG HSNG +L RK+L G D E +G+ L + LL PTRIYV+ +L+LI V
Sbjct: 187 IALGSSGPHSNGYSLVRKIL-EVSGCDPQTTELDGKPLADHLLAPTRIYVKSVLKLIEKV 245
Query: 233 EVHGLAHITGGGLL-NLKRL----TNYGFELEMPPIEGIFKLIHENG-VPLDEMFRVFNM 286
+VH +AH+TGGG N+ R+ T + +F + G V EM+R FN
Sbjct: 246 DVHAIAHLTGGGFWENIPRVLPDNTQAVIDESSWQWPEVFNWLQTAGNVERHEMYRTFNC 305
Query: 287 GVGFIVVVPQEEKEEALEILS 307
GVG I+ +P E ++AL +L+
Sbjct: 306 GVGMIIALPAPEVDKALALLN 326
>gb|AAG10596.1|AF293159_1 (AF293159) phosphoribosylaminoimidazole synthetase [Escherichia
coli]
Length = 324
Score = 198 bits (499), Expect = 6e-50
Identities = 118/283 (41%), Positives = 170/283 (59%), Gaps = 16/283 (5%)
Query: 40 GDIGHYAALLDFGNFY----LAMTTDGVGTKVLVAEAVGKFDTIGIDMIAMNVNDLLCVG 95
G +G + AL Y L TDGVGTK+ +A + + DTIGID++AM VNDL+ G
Sbjct: 19 GGLGGFGALCALPQKYREPVLVSGTDGVGTKLRLAMDLKRHDTIGIDLVAMCVNDLVVQG 78
Query: 96 AEPLALVDYFAVKEPNEEVFKQVAKGLYKGAEEAGVAIVGGETAVMPDLING--YDLAGT 153
AEPL +DY+A + + + V G+ +G ++G A+VGGETA MP + +G YD+AG
Sbjct: 79 AEPLFFLDYYATGKLDVDTASSVISGIAEGCLQSGCALVGGETAEMPGMYHGEDYDVAGF 138
Query: 154 AIGIVEKGKVITGERIRPGDSVIGISSSGIHSNGLTLARKLLIPKYGLD---YEYEGRKL 210
+G+VEK ++I G ++ GD +I + SSG HSNG +L RK +I G D E +G+ L
Sbjct: 139 CVGVVEKSEIIDGSKVSDGDVLIALGSSGPHSNGYSLVRK-IIEVSGCDPQTTELDGKPL 197
Query: 211 WEWLLEPTRIYVRPILELINSVEVHGLAHITGGGLL-NLKRL----TNYGFELEMPPIEG 265
+ LL PTRIYV+ +LELI V+VH +AH+TGGG N+ R+ T +
Sbjct: 198 ADHLLAPTRIYVKSVLELIEKVDVHAIAHLTGGGFWENIPRVLPENTQAVIDESSWQWPA 257
Query: 266 IFKLIHENG-VPLDEMFRVFNMGVGFIVVVPQEEKEEALEILS 307
+F + G V EM+R FN GVG I+ VP + ++AL +L+
Sbjct: 258 VFHWLQTAGNVSRHEMYRTFNCGVGMIIAVPAPKVDKALALLN 300
>gb|AAG14655.1|AF293203_1 (AF293203) phosphoribosylaminoimidazole synthetase [Escherichia
coli]
Length = 350
Score = 198 bits (499), Expect = 6e-50
Identities = 126/321 (39%), Positives = 186/321 (57%), Gaps = 21/321 (6%)
Query: 2 LTYAQAGVDEEKTARALREIIRTARETFKLRKGKVGEPGDIGHYAALLDFGNFY----LA 57
L+Y AGVD + + I ++T R+ +V G +G + AL Y L
Sbjct: 12 LSYKDAGVDIDAGNALVGRIKGVVKKT---RRPEV--MGGLGGFGALCALPQKYREPVLV 66
Query: 58 MTTDGVGTKVLVAEAVGKFDTIGIDMIAMNVNDLLCVGAEPLALVDYFAVKEPNEEVFKQ 117
TDGV TK+ +A + + DTIGID++AM VNDL+ GAEPL +DY+A + + +
Sbjct: 67 SGTDGVSTKLRLAMDLKRHDTIGIDLVAMCVNDLVVQGAEPLFFLDYYATGKLDVDTASA 126
Query: 118 VAKGLYKGAEEAGVAIVGGETAVMPDLING--YDLAGTAIGIVEKGKVITGERIRPGDSV 175
V G+ +G ++G ++VGGETA MP + +G YD+AG +G+VEK ++I G ++ GD +
Sbjct: 127 VISGIAEGCLQSGCSLVGGETAEMPGMYHGEDYDVAGFCVGVVEKSEIIDGSKVSDGDVL 186
Query: 176 IGISSSGIHSNGLTLARKLLIPKYGLD---YEYEGRKLWEWLLEPTRIYVRPILELINSV 232
I + SSG HSNG +L RK+L G D E +G+ L + LL PTRIYV+ +LELI V
Sbjct: 187 IALGSSGPHSNGYSLVRKIL-EVSGCDPQTTELDGKPLADHLLAPTRIYVKSVLELIEKV 245
Query: 233 EVHGLAHITGGGLL-NLKRL----TNYGFELEMPPIEGIFKLIHENG-VPLDEMFRVFNM 286
+VH +AH+TGGG N+ R+ T + +F + G V EM+R FN
Sbjct: 246 DVHAIAHLTGGGFWENIPRVLPDNTQAVIDESSWQWPEVFNWLQTAGNVERHEMYRTFNC 305
Query: 287 GVGFIVVVPQEEKEEALEILS 307
GVG I+ +P E ++AL +L+
Sbjct: 306 GVGMIIALPAPEVDKALALLN 326
>gb|AAG09178.1| (AF174494) purine biosynthetic pathway protein ADE5,7
[Kluyveromyces lactis]
Length = 792
Score = 198 bits (498), Expect = 8e-50
Identities = 124/337 (36%), Positives = 188/337 (54%), Gaps = 28/337 (8%)
Query: 2 LTYAQAGVDEEKTARALREIIRTARETFKLRKGKVGEPGDIGHYAALLDF-------GNF 54
+TYA+AGV + +++I T + T + G DIG + L D
Sbjct: 441 ITYAEAGVSVDNGNLLVQKIKATVKST-----SRPGTDSDIGGFGGLFDLKAAGYNTDET 495
Query: 55 YLAMTTDGVGTKVLVAEAVGKFDTIGIDMIAMNVNDLLCVGAEPLALVDYFAVKEPNEEV 114
L TDGVGTK+++A+ +T+GID++AMNVNDL+ GAEPL +DYFA + +V
Sbjct: 496 LLVAATDGVGTKLMIAQETDIHNTVGIDLVAMNVNDLVVQGAEPLLFLDYFATGALDIKV 555
Query: 115 FKQVAKGLYKGAEEAGVAIVGGETAVMPDLI--NGYDLAGTAIGIVEKGKVITG-ERIRP 171
G+ G +AG A+VGGET+ MP + YD GTA+G V K +++ E +
Sbjct: 556 ASDFVSGVATGCIQAGCALVGGETSEMPGMYPPGHYDTNGTAVGAVNKTQILPKVEEMGS 615
Query: 172 GDSVIGISSSGIHSNGLTLARKLLIPKYGLDYEYE-----GRKLWEWLLEPTRIYVRPIL 226
G+ ++G+SS G+HSNG +L RK +I GL +E E + L E +L PTRIYV+ +L
Sbjct: 616 GNVLLGLSSDGVHSNGFSLVRK-IIEHTGLPWEAECPWDASKTLGEAILVPTRIYVKQLL 674
Query: 227 ELINSVEVHGLAHITGGGLLN-----LKRLTNYGFELEMPPIEGIFKLIHENG-VPLDEM 280
I + GLAHITGGGL+ L + + + +FK + G VPL+++
Sbjct: 675 PSIKEQLLLGLAHITGGGLVENVPRALPKHLQAKINMNTWEVPEVFKWFGKAGNVPLEDI 734
Query: 281 FRVFNMGVGFIVVVPQEEKEEALEILSRHYKS-YELG 316
+ FNMG+G +++V +E E E+L + ++ YE+G
Sbjct: 735 LKTFNMGIGMVLIVKKENVERVTELLKQSGETVYEIG 771
>gb|AAG14581.1|AF293166_1 (AF293166) phosphoribosylaminoimidazole synthetase [Escherichia
coli]
Length = 350
Score = 198 bits (498), Expect = 8e-50
Identities = 126/321 (39%), Positives = 187/321 (58%), Gaps = 21/321 (6%)
Query: 2 LTYAQAGVDEEKTARALREIIRTARETFKLRKGKVGEPGDIGHYAALLDFGNFY----LA 57
L+Y AGVD + + I ++T R+ +V G +G + AL Y L
Sbjct: 12 LSYKDAGVDIDAGNALVGRIKGVVKKT---RRPEV--MGGLGGFGALCALPQKYREPVLV 66
Query: 58 MTTDGVGTKVLVAEAVGKFDTIGIDMIAMNVNDLLCVGAEPLALVDYFAVKEPNEEVFKQ 117
TDGVGTK+ +A + + DTIGID++AM VNDL+ GAEPL +DY+A + + +
Sbjct: 67 SGTDGVGTKLRLAMDLKRHDTIGIDLVAMCVNDLVVQGAEPLFFLDYYATGKLDVDTASA 126
Query: 118 VAKGLYKGAEEAGVAIVGGETAVMPDLING--YDLAGTAIGIVEKGKVITGERIRPGDSV 175
V G+ +G ++G ++VGGETA MP + +G YD+AG +G+VEK ++I G ++ GD +
Sbjct: 127 VISGIAEGCLQSGCSLVGGETAEMPGMYHGEDYDVAGFCVGVVEKSEIIDGSKVSDGDVL 186
Query: 176 IGISSSGIHSNGLTLARKLLIPKYGLD---YEYEGRKLWEWLLEPTRIYVRPILELINSV 232
I + SSG HSNG +L RK+L G D E +G+ L + LL PTRIYV+ +LELI V
Sbjct: 187 IALGSSGPHSNGYSLVRKIL-EVSGCDPQTTELDGKPLADHLLAPTRIYVKSVLELIEKV 245
Query: 233 EVHGLAHITGGGLL-NLKRL----TNYGFELEMPPIEGIFKLIHENG-VPLDEMFRVFNM 286
+V+ +AH+TGGG N+ R+ T + +F + G V EM+R FN
Sbjct: 246 DVNAIAHLTGGGFWENIPRVLPDNTQAVIDESSWQWPEVFNWLQTAGNVERHEMYRTFNC 305
Query: 287 GVGFIVVVPQEEKEEALEILS 307
GVG I+ +P E ++AL +L+
Sbjct: 306 GVGMIIALPAPEVDKALALLN 326
>emb|CAB46525.1| (AJ243305) 5'-phosphoribosyl-5-aminoimidazole synthetase [Rhizobium
leguminosarum]
Length = 357
Score = 196 bits (494), Expect = 2e-49
Identities = 133/349 (38%), Positives = 183/349 (52%), Gaps = 31/349 (8%)
Query: 2 LTYAQAGVDEEKTARALREIIRTARETFKLRKGKVGEPGDIGHYAALLD-----FGNFYL 56
LTY+ AGVD + + +I R T + G G+IG + L D F + L
Sbjct: 9 LTYSDAGVDIDAGNLLVEKIKPAVRST-----RRPGGDGEIGGFGGLFDLKAAAFTDPVL 63
Query: 57 AMTTDGVGTKVLVAEAVGKFDTIGIDMIAMNVNDLLCVGAEPLALVDYFAVKEPNEEVFK 116
DGVGTK+ +A DT+GID++AM VNDL+ GAEPL +DYFA + + +
Sbjct: 64 VAANDGVGTKLKIAIDADYHDTVGIDLVAMCVNDLVVQGAEPLFFLDYFATGKLDPDQGA 123
Query: 117 QVAKGLYKGAEEAGVAIVGGETAVMPDLING--YDLAGTAIGIVEKGKVITGERIRPGDS 174
+ G+ EAG A++GGETA MP + + YDLAG A+G E+GK++ I GD
Sbjct: 124 AIVGGIAARCREAGCALIGGETAEMPGMYSSGDYDLAGFAVGAAERGKLLPSGDIAEGDV 183
Query: 175 VIGISSSGIHSNGLTLARKLLIPKYGLDYE-----YEGRKLWEWLLEPTRIYVRPILELI 229
++G++SSG+HSNG +L RK ++ GLD+ E R L E LLEPTRIYV+P+L+ I
Sbjct: 184 ILGLASSGVHSNGFSLVRK-IVELSGLDWSAAAPFAERRLLGEALLEPTRIYVKPLLKAI 242
Query: 230 NSV-EVHGLAHITGGGLLN-----LKRLTNYGFELEMPPIEGIFK-LIHENGVPLDEMFR 282
+ LAHITGGG L + +L+ + +F L GV EM R
Sbjct: 243 RETGAIKALAHITGGGFPENIPRVLPKHLAAEIDLDAVKVPPVFSWLAKTGGVESREMLR 302
Query: 283 VFNMGVGFIVVVPQEEKEEALEILSRHYKSYELGNVTRELGKIKVKNYG 331
FN GVG I VV E E L G LG++ V++ G
Sbjct: 303 TFNCGVGMIAVVAAENVAAVSEALEAE------GETVITLGRMIVRDEG 345
>pir||E82789 5'-phosphoribosyl-5-aminoimidazole synthetase XF0587 [imported] -
Xylella fastidiosa (strain 9a5c)
>gi|9105451|gb|AAF83397.1|AE003904_18 (AE003904)
5'-phosphoribosyl-5-aminoimidazole synthetase [Xylella
fastidiosa]
Length = 351
Score = 196 bits (492), Expect = 4e-49
Identities = 126/346 (36%), Positives = 196/346 (56%), Gaps = 29/346 (8%)
Query: 2 LTYAQAGVDEEKTARALREIIRTARETFKLRKGKVGEPGDIGHYAALLDFGNFY----LA 57
LTY AGVD + + I + +F+ +G + AL + Y L
Sbjct: 12 LTYRDAGVDIDAGNTLVERIKPLVKRSFRPEV-----MSGLGGFGALFNLAGKYKEPVLV 66
Query: 58 MTTDGVGTKVLVAEAVGKFDTIGIDMIAMNVNDLLCVGAEPLALVDYFAVKEPNEEVFKQ 117
TDGVGTK+ +A+ + + +TIGID++AM VND+L GAEPL +DYFA + + +
Sbjct: 67 SGTDGVGTKLKLAQQLNRHNTIGIDLVAMCVNDVLVQGAEPLFFLDYFATGKLDIDTATA 126
Query: 118 VAKGLYKGAEEAGVAIVGGETAVMPDLI--NGYDLAGTAIGIVEKGKVITGERIRPGDSV 175
V G+ G E++G A++GGETA MPD+ YDLAG + VEK +++ G ++R GD +
Sbjct: 127 VISGIALGCEQSGCALIGGETAEMPDMYPPGEYDLAGFCVAAVEKSQLLDGSQVREGDVL 186
Query: 176 IGISSSGIHSNGLTLARKLLIPKYG--LDYEYEGRKLWEWLLEPTRIYVRPILELI--NS 231
IGI+SSG HSNG +L R+ + + G D + G +L + L+ PT +YV+PIL+L+ +S
Sbjct: 187 IGIASSGPHSNGYSLIRR-IYERAGSPADLDIHGTRLIDTLMAPTTLYVKPILKLLHTHS 245
Query: 232 VEVHGLAHITGGGLL-NLKRL--TNYGFELE-----MPPIEGIFKLIHENGVPLD-EMFR 282
+H +AHITGGGL N+ R+ N G ++ PP +F+ + G D EM+R
Sbjct: 246 DAIHAMAHITGGGLTENIIRVIPPNLGLRIDANAWTQPP---VFQWLQSEGALADTEMWR 302
Query: 283 VFNMGVGFIVV-VPQEEKEEALEILSRHYKSYELGNVTRELGKIKV 327
FN G+GF++V P + + ++ +++G V +G +V
Sbjct: 303 TFNCGIGFVLVATPNQVAPLGQALDNQGLAHWQIGRVFTPVGNERV 348
>gi|6857793 phosphoribosylglycinamide formyltransferase [Mus musculus]
>gi|2500003|sp|Q64737|PUR2_MOUSE TRIFUNCTIONAL PURINE
BIOSYNTHETIC PROTEIN ADENOSINE-3 [INCLUDES:
PHOSPHORIBOSYLAMINE--GLYCINE LIGASE (GARS) (GLYCINAMIDE
RIBONUCLEOTIDE SYNTHETASE) (PHOSPHORIBOSYLGLYCINAMIDE
SYNTHETASE); PHOSPHORIBOSYLFORMYLGLYCINAMIDINE
CYCLO-LIGASE (AIRS) (PHOSPHORI>
>gi|691792|gb|AAC53251.1| (U20892) glycinamide
ribonucleotide synthetase-aminoimidazole ribonucleotide
synthetase-glycinamide ribonucleotide formyltransferase
[Mus musculus]
Length = 1010
Score = 191 bits (481), Expect = 8e-48
Identities = 128/352 (36%), Positives = 200/352 (56%), Gaps = 30/352 (8%)
Query: 2 LTYAQAGVDEEKTARALREIIRTARETFKLRKGKVGEPGDIGHYAALLD-----FGNFYL 56
LTY +GVD +++I A+ T + G D+G +A L D F + L
Sbjct: 435 LTYKDSGVDIAAGNMLVKKIQPLAKAT-----SRPGCSVDLGGFAGLFDLKAAGFKDPLL 489
Query: 57 AMTTDGVGTKVLVAEAVGKFDTIGIDMIAMNVNDLLCVGAEPLALVDYFAVKEPNEEVFK 116
A TDGVGTK+ +A+ K D+IG D++AM VND+L GAEPL +DYF+ + + +
Sbjct: 490 ASGTDGVGTKLKIAQLCNKHDSIGQDLVAMCVNDILAQGAEPLFFLDYFSCGKLDLSTTE 549
Query: 117 QVAKGLYKGAEEAGVAIVGGETAVMPDLI--NGYDLAGTAIGIVEK-GKVITGERIRPGD 173
V G+ ++A A++GGETA MP++ YDLAG A+G +E+ K+ ERI GD
Sbjct: 550 AVIAGIAAACQQAACALLGGETAEMPNMYPPGEYDLAGFAVGAMERHQKLPQLERITEGD 609
Query: 174 SVIGISSSGIHSNGLTLARKLLIPKYGLDYEYEG------RKLWEWLLEPTRIYVRPILE 227
+VIG++SSG+HSNG +L RK ++ + L Y + L + LL PTRIY +L
Sbjct: 610 AVIGVASSGLHSNGFSLVRK-IVERSSLQYSSPAPGGCGDQTLGDLLLTPTRIYSHSLLP 668
Query: 228 LINSVEVHGLAHITGGGLL-NLKRLTNYGFELEMPP----IEGIFKLIHENG-VPLDEMF 281
+I S V AHITGGGLL N+ R+ F +++ + +F + + G + +EM
Sbjct: 669 IIRSGRVKAFAHITGGGLLENIPRVLPQKFGVDLDASTWRVPKVFSWLQQEGELSEEEMA 728
Query: 282 RVFNMGVGFIVVVPQEEKEEAL-EILSRHYKSYELGNVT---RELGKIKVKN 329
R FN G+G +VV +++ E+ L ++ R +++ +G+V + +++VKN
Sbjct: 729 RTFNCGIGAALVVSKDQAEQVLHDVRRRQEEAWVIGSVVACPEDSPRVRVKN 780
>pir||I67805 purine synthesis multifunctional protein - mouse
>gi|403493|gb|AAA19013.1| (U01024) glycinamide
ribonucleotide sythetase (GARS), aminoimidazole
ribonucleotide synthetase (AIRS), glycinamide
ribonucleotide formyltransferase (GART) [Mus musculus]
Length = 1010
Score = 190 bits (478), Expect = 2e-47
Identities = 128/352 (36%), Positives = 199/352 (56%), Gaps = 30/352 (8%)
Query: 2 LTYAQAGVDEEKTARALREIIRTARETFKLRKGKVGEPGDIGHYAALLD-----FGNFYL 56
LTY +GVD +++I A+ T + G D+G +A L D F + L
Sbjct: 435 LTYKDSGVDIAAGNMLVKKIQPLAKAT-----SRPGCSVDLGGFAGLFDLKAAGFKDPLL 489
Query: 57 AMTTDGVGTKVLVAEAVGKFDTIGIDMIAMNVNDLLCVGAEPLALVDYFAVKEPNEEVFK 116
A TDGVGTK+ +A+ K D+IG D++AM VND+L GAEPL +DYF+ + + +
Sbjct: 490 ASGTDGVGTKLKIAQLCNKHDSIGQDLVAMCVNDILAQGAEPLFFLDYFSCGKLDLSTTE 549
Query: 117 QVAKGLYKGAEEAGVAIVGGETAVMPDLI--NGYDLAGTAIGIVEK-GKVITGERIRPGD 173
V G+ ++A A++GGETA MP++ YDLAG A+G +E+ K+ ERI GD
Sbjct: 550 AVIAGIAAACQQAACALLGGETAEMPNMYPPGEYDLAGFAVGAMERHQKLPQLERITEGD 609
Query: 174 SVIGISSSGIHSNGLTLARKLLIPKYGLDYEYEG------RKLWEWLLEPTRIYVRPILE 227
+VIG++SSG+HSNG +L RK ++ + L Y + L + LL PTRIY +L
Sbjct: 610 AVIGVASSGLHSNGFSLVRK-IVERSSLQYSSPAPGGCGDQTLGDLLLTPTRIYSHSLLP 668
Query: 228 LINSVEVHGLAHITGGGLL-NLKRLTNYGFELEMPP----IEGIFKLIHENG-VPLDEMF 281
+I S V AHITGGGLL N R+ F +++ + +F + + G + +EM
Sbjct: 669 IIRSGRVKAFAHITGGGLLENTPRVLPQKFGVDLDASTWRVPKVFSWLQQEGELSEEEMA 728
Query: 282 RVFNMGVGFIVVVPQEEKEEAL-EILSRHYKSYELGNVT---RELGKIKVKN 329
R FN G+G +VV +++ E+ L ++ R +++ +G+V + +++VKN
Sbjct: 729 RTFNCGIGAALVVSKDQAEQVLHDVRRRQEEAWVIGSVVACPEDSPRVRVKN 780
>gi|6321203 glycinamide ribotide synthetase and aminoimidazole ribotide
synthetase; Ade5,7p [Saccharomyces cerevisiae]
>gi|131619|sp|P07244|PUR2_YEAST BIFUNCTIONAL PURINE
BIOSYNTHETIC PROTEIN ADE5,7 [INCLUDES:
PHOSPHORIBOSYLAMINE--GLYCINE LIGASE (GARS) (GLYCINAMIDE
RIBONUCLEOTIDE SYNTHETASE) (PHOSPHORIBOSYLGLYCINAMIDE
SYNTHETASE); PHOSPHORIBOSYLFORMYLGLYCINAMIDINE
CYCLO-LIGASE (AIRS) (PHOSPHORIBOSYL->
>gi|83383|pir||A26343 ADE5 multifunctional protein -
yeast (Saccharomyces cerevisiae)
>gi|3335|emb|CAA27867.1| (X04337) ADE5,7 gene product
(aa 1-802) GARSase (EC 6.3.4.13)/AIRSase [Saccharomyces
cerevisiae] >gi|1322895|emb|CAA96952.1| (Z72756) ORF
YGL234w [Saccharomyces cerevisiae]
Length = 802
Score = 190 bits (477), Expect = 2e-47
Identities = 123/350 (35%), Positives = 192/350 (54%), Gaps = 40/350 (11%)
Query: 2 LTYAQAGVDEEK---TARALREIIRTARETFKLRKGKVGEPGDIGHYAALLDFG------ 52
+TYA +GV + + ++E++R+ R + G DIG + L D
Sbjct: 450 ITYADSGVSVDNGNNLVQTIKEMVRSTR--------RPGADSDIGGFGGLFDLAQAGFRQ 501
Query: 53 --NFYLAMTTDGVGTKVLVAEAVGKFDTIGIDMIAMNVNDLLCVGAEPLALVDYFAVKEP 110
+ L TDGVGTK+++A+ G +T+GID++AMNVNDL+ GAEPL +DYFA
Sbjct: 502 NEDTLLVGATDGVGTKLIIAQETGIHNTVGIDLVAMNVNDLVVQGAEPLFFLDYFATGAL 561
Query: 111 NEEVFKQVAKGLYKGAEEAGVAIVGGETAVMPDLI--NGYDLAGTAIGIVEKGKVITG-E 167
+ +V G+ G ++G A+VGGET+ MP + YD GTA+G V + ++
Sbjct: 562 DIQVASDFVSGVANGCIQSGCALVGGETSEMPGMYPPGHYDTNGTAVGAVLRQDILPKIN 621
Query: 168 RIRPGDSVIGISSSGIHSNGLTLARKLLIPKYGLDYEY-----EGRKLWEWLLEPTRIYV 222
+ GD ++G++SSG+HSNG +L RK +I L ++ E + L E +LEPT+IYV
Sbjct: 622 EMAAGDVLLGLASSGVHSNGFSLVRK-IIQHVALPWDAPCPWDESKTLGEGILEPTKIYV 680
Query: 223 RPILELINSVEVHGLAHITGGGLL-NLKRL----TNYGFELEMPPIEGIFKLIHENG-VP 276
+ +L I + GLAHITGGGL+ N+ R ++ + +FK + G VP
Sbjct: 681 KQLLPSIRQRLLLGLAHITGGGLVENIPRAIPDHLQARVDMSTWEVPRVFKWFGQAGNVP 740
Query: 277 LDEMFRVFNMGVGFIVVVPQEEKEEALEILSRHYKSYELGNVTRELGKIK 326
D++ R FNMGVG +++V +E + + L+ E G + ELG ++
Sbjct: 741 HDDILRTFNMGVGMVLIVKRENVKAVCDSLT------EEGEIIWELGSLQ 784
>pir||G81299 phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1) Cj1529c
[imported] - Campylobacter jejuni (strain NCTC 11168)
>gi|6968948|emb|CAB73945.1| (AL139078)
phosphoribosylformylglycinamidine cyclo-ligase
[Campylobacter jejuni]
Length = 329
Score = 187 bits (469), Expect = 2e-46
Identities = 127/316 (40%), Positives = 176/316 (55%), Gaps = 21/316 (6%)
Query: 2 LTYAQAGVDEEKTARALREIIRTARETFKLRKGKVGEPGDI-GHYAALLDFGNFYLAMTT 60
++Y AGV + + I +ETF VG G G + F + T
Sbjct: 3 ISYEDAGVSIDNGNTFVEAIKPLVKETFN--DNVVGGIGSFAGAFRMPSGFKKPVILGAT 60
Query: 61 DGVGTKVLVAEAVGKFDTIGIDMIAMNVNDLLCVGAEPLALVDYFAVKEPNEEVFKQVAK 120
DGVGTK+ +A K+DTIG D++AM VNDL+C A PL +DY+A + EV K V
Sbjct: 61 DGVGTKLRLAIDAKKYDTIGQDLVAMCVNDLICNFATPLFFLDYYATAKLEVEVAKAVVS 120
Query: 121 GLYKGAEEAGVAIVGGETAVMPDLI--NGYDLAGTAIGIVEKGKVITGERIRPGDSVIGI 178
G+ KG + A A++GGETA MP + + +DLAG A+G+ E+ ++ + ++ GD ++ +
Sbjct: 121 GIAKGCKMANCALIGGETAEMPGMYAKDDFDLAGFAVGMAEEDEIDRSKFVKNGDILLAL 180
Query: 179 SSSGIHSNGLTLARKLLIP--KYGLDYEYEGRKLWEWLLEPTRIYVRPILELINSVEVHG 236
SSSG+HSNG +LARK+L K D + EG+ L + LLEPTRIYVR L L +
Sbjct: 181 SSSGLHSNGYSLARKVLFESLKLKFDDKIEGKNLIDILLEPTRIYVRDFLTL--KPYISA 238
Query: 237 LAHITGGGLL-NLKRLTNYGF-------ELEMPPIEGIFKLIHENGVPLDEMFRVFNMGV 288
LAHITGGGL+ NL R+ G L+ P IF I + V EM+R FNMGV
Sbjct: 239 LAHITGGGLVENLPRVLPRGMGATIRKHHLKTPE---IFYTIGQ-AVEESEMYRSFNMGV 294
Query: 289 GFIVVVPQEEKEEALE 304
G ++VV + LE
Sbjct: 295 GLVMVVDPSNVSKILE 310
>sp|Q26255|PUR2_CHITE TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADENOSINE-3 [INCLUDES:
PHOSPHORIBOSYLAMINE--GLYCINE LIGASE (GARS) (GLYCINAMIDE
RIBONUCLEOTIDE SYNTHETASE) (PHOSPHORIBOSYLGLYCINAMIDE
SYNTHETASE); PHOSPHORIBOSYLFORMYLGLYCINAMIDINE
CYCLO-LIGASE (AIRS) (PHOSPHORI> >gi|254730|gb|AAB23115.1|
(S43653) glycinamide ribonucleotide synthetase,
aminoimidazole ribonucleotide synthetase, glycinamide
ribonucleotide transformylase {EC 6.3.4.13, 6.3.3.1,
2.1.2.2} [Chironomus tentans, Peptide, 1371 aa]
Length = 1371
Score = 182 bits (458), Expect = 4e-45
Identities = 119/329 (36%), Positives = 177/329 (53%), Gaps = 23/329 (6%)
Query: 2 LTYAQAGVDEEKTARALREIIRTARETFKLRKGKVGEPGDIGHYAALLDFGNFY----LA 57
++Y +GVD + I A+ T RKG +G G G + + G + L
Sbjct: 808 ISYKDSGVDITAGNELVDNIKPHAKSTN--RKGVIGGLGSFGGLFRINECGTKFEDPMLV 865
Query: 58 MTTDGVGTKVLVAEAVGKFDTIGIDMIAMNVNDLLCVGAEPLALVDYFAVKEPNEEVFKQ 117
+ TDGVGTK+ +A+ +GK DT+GID++AM ND+LC GAEPL +DYFA + + V
Sbjct: 866 LATDGVGTKLKIAQQLGKHDTVGIDLVAMCNNDILCNGAEPLTFLDYFACGKLDVNVATN 925
Query: 118 VAKGLYKGAEEAGVAIVGGETAVMPDLING--YDLAGTAIGIVEKGKVITGER-IRPGDS 174
V G+ +G ++ ++GGETA MP + N YDLAG ++G+ E ++ + + GD
Sbjct: 926 VVSGIAEGCRQSDSTLLGGETAEMPGMYNPNVYDLAGFSLGVAEHEDILPKKNCLEVGDI 985
Query: 175 VIGISSSGIHSNGLTLARKLL-IPKYG----LDYEYEGRKLWEWLLEPTRIYVRPILELI 229
+IG S+G+HSNG +L KL + Y + G+ E LEPT++YV+ I +
Sbjct: 986 IIGFPSNGVHSNGFSLIHKLFELTGYKWTDIAPFSAYGKTFGEEFLEPTKVYVKEISPAL 1045
Query: 230 NSVEVHGLAHITGGGLL-NLKRLTNYGFELEMPP----IEGIFKLIHENG-VPLDEMFRV 283
+ V LAHITGGGL N+ R+ Y E+ I +F + NG + E+ +
Sbjct: 1046 KTGYVKALAHITGGGLWDNIPRVLPYNLTAELDAKKINISPVFAWLSLNGNIDKLELLKT 1105
Query: 284 FNMGVGFIVVVPQEEKEEALEILSRHYKS 312
FN G+G I++ KE LEIL Y S
Sbjct: 1106 FNCGIGMIMIA---SKEHELEILKSLYGS 1131
Score = 175 bits (439), Expect = 7e-43
Identities = 116/329 (35%), Positives = 172/329 (52%), Gaps = 36/329 (10%)
Query: 2 LTYAQAGVDEEKTARALREIIRTARETFKLRKGKVGEPGDIGHYAALLD----------- 50
LTY ++GV+ E + I + T R G VG+ G G L D
Sbjct: 437 LTYKESGVNIEAGNSLVGRIKSLSYGTH--RSGVVGQIGSFGGLMRLNDIKYINSNGEES 494
Query: 51 -FGNFYLAMTTDGVGTKVLVAEAVGKFDTIGIDMIAMNVNDLLCVGAEPLALVDYFAVKE 109
+ + L TDGVGTK+ +AE++ +DTIGID++AM VND+LC GAEP+ +DY A
Sbjct: 495 NYKDIVLVQGTDGVGTKLKIAESMNVWDTIGIDLVAMCVNDVLCNGAEPIGFLDYIACGH 554
Query: 110 PNEEVFKQVAKGLYKGAEEAGVAIVGGETAVMPDLI--NGYDLAGTAIGIVEKGKVITG- 166
+ KG+ G +A A++GGETA MP + YDLAG +GI E +++
Sbjct: 555 LEVPTVATIVKGIADGCRKANCALIGGETAEMPSMYGKGKYDLAGYCVGITEYDEILPKI 614
Query: 167 ERIRPGDSVIGISSSGIHSNGLTLARKLL---------IPKYGLDYEYEGRKLWEWLLEP 217
+ GD VIG+ SSGIHSNG +L K+ I ++ ++ G + L P
Sbjct: 615 NDVHVGDVVIGLPSSGIHSNGFSLVNKIFQQTGFKLTDIAEFSDSHKSYGME----FLTP 670
Query: 218 TRIYVRPILELINSVEVHGLAHITGGGLL-NLKRLTNYGFELEMP----PIEGIFKLIHE 272
TR+YV L + + V LAHITGGGLL N+ R+ +++ + +F +
Sbjct: 671 TRLYVSETLPFLRNGYVKALAHITGGGLLENIPRILPNHLSVQIDALTWKLPKVFSWLAA 730
Query: 273 NG-VPLDEMFRVFNMGVGFIVVVPQEEKE 300
+G V +EM R FN G+G I+++P+ + E
Sbjct: 731 HGNVNANEMLRTFNCGIGMIIIMPRNDIE 759
>sp|Q05728|PUR5_ARATH PHOSPHORIBOSYLFORMYLGLYCINAMIDINE CYCLO-LIGASE PRECURSOR (AIRS)
(PHOSPHORIBOSYL-AMINOIMIDAZOLE SYNTHETASE) (AIR
SYNTHASE) >gi|541885|pir||JQ2256
phosphoribosylformylglycinamidine cyclo-ligase (EC
6.3.3.1) precursor - Arabidopsis thaliana
>gi|289188|gb|AAC37341.1| (L12457)
5'-phosphoribosyl-5-aminoimidazole synthetase
[Arabidopsis thaliana]
Length = 355
Score = 182 bits (457), Expect = 5e-45
Identities = 115/286 (40%), Positives = 163/286 (56%), Gaps = 30/286 (10%)
Query: 2 LTYAQAGVDEEKTARALREIIRTARETFKLRKGKVGEPGDIGHYAALLDFGNFYLAMTTD 61
L Y +GVD + A ++ I + A PG IG + L G+ YL TD
Sbjct: 66 LNYKDSGVDIDAGAELVKRIAKMA-------------PG-IGGFGGLFPLGDSYLVAGTD 111
Query: 62 GVGTKVLVAEAVGKFDTIGIDMIAMNVNDLLCVGAEPLALVDYFAVKEPNEEVFKQVAKG 121
GVGTK+ +A G DTIGID++AM+VND++ GA+PL +DYFA + ++ ++V KG
Sbjct: 112 GVGTKLKLAFETGIHDTIGIDLVAMSVNDIITSGAKPLFFLDYFATSRLDVDLAEKVIKG 171
Query: 122 LYKGAEEAGVAIVGGETAVMPDLI--NGYDLAGTAIGIVEKGKVITGERIRPGDSVIGIS 179
+ +G ++ A++GGETA MPD YDL+G A+GIV+K VI G+ I GD +IG+
Sbjct: 172 IVEGCRQSECALLGGETAEMPDFYAEGEYDLSGFAVGIVKKTSVINGKNIVAGDVLIGLP 231
Query: 180 SSGIHSNGLTLARKLLI-PKYGLDYEYEG--RKLWEWLLEPTRIYVRPILELINSVEVHG 236
SSG+HSNG +L R++L L G L + L+ PT IYV+ +L++I V G
Sbjct: 232 SSGVHSNGFSLVRRVLARSNLSLKDALPGGSSTLGDALMAPTVIYVKQVLDMIEKGGVKG 291
Query: 237 LAHITGGGLL-NLKRLTNYGF-------ELEMPPIEGIFKLIHENG 274
LAHITGGG N+ R+ G E+PP +FK I + G
Sbjct: 292 LAHITGGGFTDNIPRVFPDGLGAVIHTDAWELPP---LFKWIQQTG 334
>gb|AAF71749.1| (AF257743) phosphoribosylglycinamide formyltransferase; Gart [Danio
rerio]
Length = 1017
Score = 179 bits (449), Expect = 5e-44
Identities = 123/340 (36%), Positives = 183/340 (53%), Gaps = 30/340 (8%)
Query: 2 LTYAQAGVDEEKTARALREIIRTARETFKLRKGKVGEPGDIGHYAALLD-----FGNFYL 56
LTY +GVD R + I A+ T + G D+G +A L D F + L
Sbjct: 436 LTYKDSGVDIAAGNRLVDIIKPLAKAT-----SRPGCNADLGGFAGLFDLKAAGFTDPIL 490
Query: 57 AMTTDGVGTKVLVAEAVGKFDTIGIDMIAMNVNDLLCVGAEPLALVDYFAVKEPNEEVFK 116
TDGVGTK+ +A+ G T+G D++AM VND+L GAEPL +DYF+ + V
Sbjct: 491 VSGTDGVGTKLKIAQECGVHSTLGQDLVAMCVNDVLAQGAEPLFFLDYFSCGRLDVNVAA 550
Query: 117 QVAKGLYKGAEEAGVAIVGGETAVMPDLI--NGYDLAGTAIGIVEKGKVITG-ERIRPGD 173
V G+ + AG A++GGETA MP + YDLAG +G VE+ ++ + I GD
Sbjct: 551 SVIGGIADACQMAGCALLGGETAEMPGVYPPGEYDLAGFCVGAVERSALLPRLKDISEGD 610
Query: 174 SVIGISSSGIHSNGLTLARKLLIPKYGLD------YEYEGRKLWEWLLEPTRIYVRPILE 227
++G+SSSGIHSNG +L R +L + GL+ + G+ + + LL PT+IY R +
Sbjct: 611 LLLGVSSSGIHSNGFSLVRTIL-ERSGLNISSPAPFGRPGQTIGDVLLTPTKIYSRVLQP 669
Query: 228 LINSVEVHGLAHITGGGLL-NLKRLTNYGFELEM-------PPIEGIFKLIHENGVPLDE 279
++ S V AHITGGGLL N+ R+ ++ PP+ L + GV E
Sbjct: 670 VLRSGAVKAFAHITGGGLLENIPRVLPADLTADLDACRWRIPPV--FSWLQQQGGVCEQE 727
Query: 280 MFRVFNMGVGFIVVVPQEEKEEALEILSRHYKSYELGNVT 319
R FN G+G ++VV + + + L +L H +S+ +G++T
Sbjct: 728 FCRTFNCGLGAVLVVSKADAQRVLRLLQAHEESWIIGSLT 767
>gb|AAC96120.1| (AF083221) glycinamide ribonucleotide transformylase [Takifugu
rubripes]
Length = 1008
Score = 176 bits (443), Expect = 2e-43
Identities = 121/314 (38%), Positives = 175/314 (55%), Gaps = 28/314 (8%)
Query: 2 LTYAQAGVDEEKTARALREIIRTARETFKLRKGKVGEPGDIGHYAALLD-----FGNFYL 56
LTY +GVD + + I A+ T + G ++G +A L D F + L
Sbjct: 435 LTYKDSGVDIAAGNKLVETIKPLAKAT-----SRPGCNAELGGFAGLFDLKAAGFVDPIL 489
Query: 57 AMTTDGVGTKVLVAEAVGKFDTIGIDMIAMNVNDLLCVGAEPLALVDYFAVKEPNEEVFK 116
TDGVGTK+ +A+A G+ +G D++AM VND+L GAEPL +DYF+ + +V
Sbjct: 490 VSGTDGVGTKLKIAQACGRHGGLGQDLVAMCVNDVLAQGAEPLFFLDYFSCGSLDVDVAS 549
Query: 117 QVAKGLYKGAEEAGVAIVGGETAVMPDLING--YDLAGTAIGIVEKGKVI--TGERIRPG 172
V G+ K E AG A++GGETA MP + + YDLAG +G VE+G ++ G+ I G
Sbjct: 550 SVIGGIAKACEMAGCALLGGETAEMPGVYSAGEYDLAGFCVGAVERGALLPRIGD-ITEG 608
Query: 173 DSVIGISSSGIHSNGLTLARKLLIPKYGLDYE------YEGRKLWEWLLEPTRIYVRPIL 226
D +IG++SSG+HSNG +L RK+L + L Y + + E LL PT+IY R +L
Sbjct: 609 DLLIGVASSGVHSNGFSLVRKVL-ERANLSYSSPSPFGTSAQTIGEALLTPTKIYSRLLL 667
Query: 227 ELINSVEVHGLAHITGGGLL-NLKRLTNYGFELEMP----PIEGIFK-LIHENGVPLDEM 280
++ S V AHITGGGLL N+ R+ +++ I +F L E G+ EM
Sbjct: 668 PILRSGAVKAYAHITGGGLLENIPRVLPQELAVDIDASRWSIPSVFSWLYKEGGLSEAEM 727
Query: 281 FRVFNMGVGFIVVV 294
R FN G+G ++VV
Sbjct: 728 TRTFNCGLGAVLVV 741
>pir||B75400 phosphoribosylformylglycinamidine cyclo-ligase - Deinococcus
radiodurans (strain R1)
>gi|6459151|gb|AAF10965.1|AE001985_2 (AE001985)
phosphoribosylformylglycinamidine cyclo-ligase
[Deinococcus radiodurans]
Length = 354
Score = 169 bits (425), Expect = 3e-41
Identities = 110/276 (39%), Positives = 161/276 (57%), Gaps = 19/276 (6%)
Query: 46 AALLDFGNFYLAMTTDGVGTKVLVAEAVGKFDTIGIDMIAMNVNDLLCVGAEPLALVDYF 105
AA D + L +TDGVGTK VA VG+F +G D++ VND+L GA PL +DY
Sbjct: 56 AAFGDMADPVLVASTDGVGTKTKVAVKVGQFGGLGHDIVNHCVNDILVQGARPLFFLDYV 115
Query: 106 AVKEPNEEVFKQVAKGLYKGAEEAGVAIVGGETAVMPDL-ING-YDLAGTAIGIVEKGKV 163
A+ + E +V G + E GVA++GGETA MP + ++G D+ GT +G+V++ +
Sbjct: 116 AMGKLRPEAVAEVVSGAAQACEALGVALLGGETAEMPGVYVDGELDIVGTIVGVVDRPNL 175
Query: 164 ITGERIRPGDSVIGISSSGIHSNGLTLARKLLIPKYGLDY-----EYEGRKLWEWLLEPT 218
I G RI GD+VI + SSG+H+NG +LAR L LD+ + G+ L L P
Sbjct: 176 IDGGRIEVGDAVIALPSSGLHTNGFSLARMAL---DALDWNEARSDLGGQTLAAVLPVPH 232
Query: 219 RIYVRPILELIN--SVEVHGLAHITGGGLL-NLKRLTNYGFELEMP----PIEGIFKLI- 270
R Y+ P + + V+V G+AHITGGGL+ N R+ G +++ + +F+LI
Sbjct: 233 RSYL-PAYDALEKAGVDVRGMAHITGGGLVDNPPRVFPQGIGMQVDTASWAVPPLFELIV 291
Query: 271 HENGVPLDEMFRVFNMGVGFIVVVPQEEKEEALEIL 306
E GV E FR NMGVGF+ +VP ++E+A++ L
Sbjct: 292 REAGVERQEAFRALNMGVGFLFIVPAAQREQAMQTL 327
>pir||E72277 phosphoribosylformylglycinamidine cyclo-ligase - Thermotoga
maritima (strain MSB8)
>gi|4981806|gb|AAD36326.1|AE001780_10 (AE001780)
phosphoribosylformylglycinamidine cyclo-ligase
[Thermotoga maritima]
Length = 311
Score = 161 bits (404), Expect = 9e-39
Identities = 115/315 (36%), Positives = 176/315 (55%), Gaps = 38/315 (12%)
Query: 3 TYAQAGVDEEKTARALREIIRTARETFKLRKGKVGEPGDIGHYAALLDFGNFYLAMTTDG 62
TY +AGVD E+ +T + KL + + EP YA++L + +T DG
Sbjct: 4 TYREAGVDVERG----ESFAKTIKSAVKLPEWVMKEPTG---YASILTITTPPVVVTADG 56
Query: 63 VGTKVLVAEAVGKFDTIGIDMIAMNVNDLLCVGAEPLALVDYFAVKEPNEEVFKQVAKGL 122
+GTK+++ G + D++ MN NDL+CVGA P+A +DY V+ +EE + K L
Sbjct: 57 IGTKLILHRKHGTWRYAAEDLVGMNYNDLVCVGARPVAFLDYLGVERISEE-HESFIKEL 115
Query: 123 YKGAEEAGVAIVGGETAVMPDLING-YDLAGTAIGIVEKGKVITGERIRPGDSVIGISSS 181
+ V +VGGETA MPD+ G +D G A+G++EK I ++I+ GD ++GI SS
Sbjct: 116 VNVLDSVDVKLVGGETAEMPDVYRGDWDAVGFAVGVLEKR--IPVDKIKEGDVIVGIPSS 173
Query: 182 GIHSNGLTLARKLLIPKYGLDYEYEGRKLWEW---LLEPTRIYVRPILELINSVEVHGLA 238
G HSNG +L R+++ + E K+ E LL+ TRIY R ++EL + V+ G+A
Sbjct: 174 GFHSNGWSLIRRII--------KEESIKIEELPFELLKGTRIY-REVIELFDLVK--GIA 222
Query: 239 HITGGGLLN-LKR-LTNYGFELEMPP---IEGIFKLIHENGVPLDEMFRVFNMGVGFIVV 293
H+TGGG++ LKR L G + +P ++ I K + N E FNMGVG ++
Sbjct: 223 HVTGGGVVRALKRVLGKLGAHVSLPKRDFVDWILKYVDFN-----EAVNTFNMGVGMFLI 277
Query: 294 VPQEEKEEALEILSR 308
V EK++ E+L+R
Sbjct: 278 V---EKQKVDEVLAR 289
>gb|AAF52474.1| (AE003615) ade3 gene product [Drosophila melanogaster]
Length = 1747
Score = 155 bits (389), Expect = 5e-37
Identities = 102/300 (34%), Positives = 167/300 (55%), Gaps = 24/300 (8%)
Query: 56 LAMTTDGVGTKVLVAEAVGKFDTIGIDMIAMNVNDLLCVGAEPLALVDYFAVKEPNEEVF 115
L + TDGVGTK+ +A+ + ++GID++AM VND+LC GAEP++ Y+A E++
Sbjct: 1240 LILGTDGVGTKLKIAQQTNRNTSVGIDLVAMCVNDILCNGAEPISFSSYYACGHWQEQLA 1299
Query: 116 KQVAKGLYKGAEEAGVAIVGGETAVMPDLING--YDLAGTAIGIVE-KGKVITGERIRPG 172
K+V G+ +GA +A + + +A +P L YDLAG A+GI E G + + I+PG
Sbjct: 1300 KEVHSGVQEGARQANSSFIDSHSAALPLLYEPQVYDLAGFALGIAEHTGILPLLDEIQPG 1359
Query: 173 DSVIGISSSGIHSNGLTLARKLLIPKYGLDYE----YEGRKLWEWLLEPTRIYVRPILEL 228
D +IG+ SSG+HSNG +L +L + GL + + L E LL PT+IYV+ + L
Sbjct: 1360 DVLIGLPSSGVHSNGFSLVHAVL-KRVGLGLHDKAPFSDKTLGEELLVPTKIYVKALSTL 1418
Query: 229 INSVE--VHGLAHITGGGLL-NLKRLTNYGF-------ELEMPPIEGIFKLIHENGVPLD 278
++ + + LAHITGGGL N+ R+ + ++PP+ L +
Sbjct: 1419 LSRGKHGIKALAHITGGGLSENIPRVLRKDLAVRLDANKFQLPPV--FAWLAAAGNISST 1476
Query: 279 EMFRVFNMGVGFIVVVPQEEKEEALEILSRHYKSYELGNVTR----ELGKIKVKNYGITL 334
E+ R +N G+G ++VV E E+ L+ L ++ +G V + ++ V+N+ +L
Sbjct: 1477 ELQRTYNCGLGMVLVVAPTEVEDVLKELRYPQRAAVVGEVVARKDPKKSQVVVQNFEASL 1536
Score = 138 bits (344), Expect = 9e-32
Identities = 101/316 (31%), Positives = 163/316 (50%), Gaps = 20/316 (6%)
Query: 2 LTYAQAGVDEEKTARALREIIRTARETFKLRKGKVGEPGDIGHYAAL--LDFGNFYLAMT 59
L+Y +GVD + ++ I +R T R G +G G G L L + +A
Sbjct: 836 LSYKDSGVDIDAGDALVQRIKPLSRGT--QRPGVIGGLGGFGGLFRLKELTYKEPVIAEA 893
Query: 60 TDGVGTKVLVAEAVGKFDTIGIDMIAMNVNDLLCVGAEPLALVDYFAVKEPNEEVFKQVA 119
T GVG K+ +A ++ +G D+ A+ ND+L VGAEP+A +DY A + + Q+
Sbjct: 894 TQGVGAKIHLALTHELYENVGYDLFALAANDVLEVGAEPVAFLDYIACGKLQVPLAAQLV 953
Query: 120 KGLYKGAEEAGVAIVGGETAVMPDLI--NGYDLAGTAIGIVEKGKVITG-ERIRPGDSVI 176
KG+ G +A A+VGGETA MP L +D+AG +GIVE+ +++ + +PGD +I
Sbjct: 954 KGMADGCRDARCALVGGETAEMPSLYAPGQHDMAGYCVGIVEQSRILPRFDLYQPGDLLI 1013
Query: 177 GISSSGIHSNG-------LTLARKLLIPKYGLDYEYEGRKLWEWLLEPTRIYVRPIL-EL 228
G+ SSG+H G L ++ L + +D +G L L PT++YV+ +L L
Sbjct: 1014 GLPSSGLHCAGFNEILTQLAASKVNLRERSPVDGGDDGLTLAHVLATPTQLYVQQLLPHL 1073
Query: 229 INSVEVHGLAHITGGGLLNLKRLTNYGFELEMP----PIEGIFK-LIHENGVPLDEMFRV 283
E+ +AH+T G L ++ RL GFE + P+ IF L + + +
Sbjct: 1074 QKGDEIKSVAHVTHGLLNDILRLLPDGFETTLDFGAVPVPKIFGWLAGKLKLSAQTILER 1133
Query: 284 FNMGVGFIVVVPQEEK 299
N G+G ++++PQ +
Sbjct: 1134 HNCGIGMVLILPQSSQ 1149
>pir||T16297 hypothetical protein F38B6.4 - Caenorhabditis elegans
>gi|1055176|gb|AAA81142.1| (U40060) coded for by C.
elegans cDNA yk45e7.3; coded for by C. elegans cDNA
yk45e7.5; similar to the multifunctional enzyme in
purine biosynthesis phosphoribosylamine-glycine
ligase/phosphoribosylformylglycinamidine
cyclo-ligase/phosphoribosylglycina>
Length = 946
Score = 155 bits (388), Expect = 7e-37
Identities = 113/342 (33%), Positives = 177/342 (51%), Gaps = 33/342 (9%)
Query: 2 LTYAQAGVDEEKTARALREIIRTARETFKLRKGKVGEPG--DIGHYAALLDF------GN 53
L+Y +GV+ ++ + + +I KL K PG IG + A+LD +
Sbjct: 395 LSYGSSGVNIDEGNQFVEDI--------KLLVKKTLLPGAAQIGGFGAVLDLKKAGFSND 446
Query: 54 FYLAMTTDGVGTKVLVAEAVGKFDTIGIDMIAMNVNDLLCVGAEPLALVDYFAVKEPNEE 113
L + DGVGTK+ VA F +G D++AM VND++C A+P+A +DYF +
Sbjct: 447 SQLVVGIDGVGTKIEVATHCNNFTGVGYDVVAMCVNDVICHCAKPIAFLDYFVCGKLERS 506
Query: 114 VFKQVAKGLYKGAEEAGVAIVGGETAVMPDL--INGYDLAGTAIGIVEK--GKVITGERI 169
+ QV + + EA +++GGETA MP + + +DLAG AI E + I
Sbjct: 507 MATQVLTSISEACVEAECSLIGGETAEMPGVYSTHQWDLAGCAIAARESTWPMLPLSSEI 566
Query: 170 RPGDSVIGISSSGIHSNGLTLARKLLI---PKYGLDYEYEGRKLW-EWLLEPTRIYVRPI 225
R GD ++G+ SSG+HSNG +LARK+L KY ++ + + LL T++YV+ +
Sbjct: 567 RDGDVILGLPSSGLHSNGFSLARKILTVNGVKYNDPLPWDSKSTFGTELLRGTKLYVKKV 626
Query: 226 LELINSVEVHGLAHITGGGL-------LNLKRLTNYGFELEMPPIEGIFKLIHENG-VPL 277
L L+++ V G AHITGGGL L+ + + IF + G V
Sbjct: 627 LPLLSTGLVKGCAHITGGGLTENAIRVLDKNSKDSLVIDCASWKFREIFNWMAAAGPVDT 686
Query: 278 DEMFRVFNMGVGFIVVVPQEEKEEALEILSRHYKS-YELGNV 318
EM R FN G+G +++V + E+ + L +H + YE+G+V
Sbjct: 687 KEMIRTFNCGIGMVLIVSPDNVEKVKKQLRKHEEEFYEIGHV 728
>sp|P00967|PUR2_DROME TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADENOSINE-3 [INCLUDES:
PHOSPHORIBOSYLAMINE--GLYCINE LIGASE (GARS) (GLYCINAMIDE
RIBONUCLEOTIDE SYNTHETASE) (PHOSPHORIBOSYLGLYCINAMIDE
SYNTHETASE); PHOSPHORIBOSYLFORMYLGLYCINAMIDINE
CYCLO-LIGASE (AIRS) (PHOSPHORI> >gi|68649|pir||AJFFPM
purine synthesis multifunctional protein - fruit fly
(Drosophila melanogaster) >gi|157482|gb|AAA28563.1|
(J02527) Gart polypeptide 4.7 kb transcript [Drosophila
melanogaster] >gi|295747|emb|CAA29612.1| (X06286)
GARS-AIRS-GART polypeptide [Drosophila melanogaster]
Length = 1353
Score = 153 bits (382), Expect = 3e-36
Identities = 102/300 (34%), Positives = 165/300 (55%), Gaps = 24/300 (8%)
Query: 56 LAMTTDGVGTKVLVAEAVGKFDTIGIDMIAMNVNDLLCVGAEPLALVDYFAVKEPNEEVF 115
L + TDGVGTK+ +A+ + ++GID++AM VND+LC GAEP++ Y+A E++
Sbjct: 846 LILGTDGVGTKLKIAQQTNRNTSVGIDLVAMCVNDILCNGAEPISFSSYYACGHWQEQLA 905
Query: 116 KQVAKGLYKGAEEAGVAIVGGETAVMPDLING--YDLAGTAIGIVE-KGKVITGERIRPG 172
K V G+ +GA +A + + +A +P L YDLAG A+GI E G + I+PG
Sbjct: 906 KGVHSGVQEGARQANSSFIDSHSAALPLLYEPQVYDLAGFALGIAEHTGILPLLAEIQPG 965
Query: 173 DSVIGISSSGIHSNGLTLARKLLIPKYGLDYE----YEGRKLWEWLLEPTRIYVRPILEL 228
D +IG+ SSG+HSNG +L +L + GL + + L E LL PT+IYV+ + L
Sbjct: 966 DVLIGLPSSGVHSNGFSLVHAVL-KRVGLGLHDKAPFSDKTLGEELLVPTKIYVKALSTL 1024
Query: 229 INSVE--VHGLAHITGGGLL-NLKRLTNYGF-------ELEMPPIEGIFKLIHENGVPLD 278
++ + + LAHITGGGL N+ R+ + ++PP+ L +
Sbjct: 1025 LSRGKHGIKALAHITGGGLSENIPRVLRKDLAVRLDANKFQLPPV--FAWLAAAGNISST 1082
Query: 279 EMFRVFNMGVGFIVVVPQEEKEEALEILSRHYKSYELGNVTR----ELGKIKVKNYGITL 334
E+ R +N G+G ++VV E E+ L+ L ++ +G V + ++ V+N+ +L
Sbjct: 1083 ELQRTYNCGLGMVLVVAPTEVEDVLKELRYPQRAAVVGEVVARKDPKKSQVVVQNFEASL 1142
Score = 137 bits (341), Expect = 2e-31
Identities = 101/316 (31%), Positives = 162/316 (50%), Gaps = 20/316 (6%)
Query: 2 LTYAQAGVDEEKTARALREIIRTARETFKLRKGKVGEPGDIGHYAAL--LDFGNFYLAMT 59
L+Y +GVD + ++ I +R T R G +G G G L L + +A
Sbjct: 442 LSYKDSGVDIDAGDALVQRIKPLSRGT--QRPGVIGGLGGFGGLFRLKELTYKEPVIAEA 499
Query: 60 TDGVGTKVLVAEAVGKFDTIGIDMIAMNVNDLLCVGAEPLALVDYFAVKEPNEEVFKQVA 119
T GVG K+ +A ++ +G D+ A+ ND+L VGAEP+A +DY A + + Q+
Sbjct: 500 TQGVGAKIHLALTHEFYENVGYDLFALAANDVLEVGAEPVAFLDYIACGKLQVPLAAQLV 559
Query: 120 KGLYKGAEEAGVAIVGGETAVMPDLI--NGYDLAGTAIGIVEKGKVITG-ERIRPGDSVI 176
KG+ G +A A+VGGETA MP L +D+AG +GIVE +++ + +PGD +I
Sbjct: 560 KGMADGCRDARCALVGGETAEMPSLYAPGQHDMAGYCVGIVEHSRILPRFDLYQPGDLLI 619
Query: 177 GISSSGIHSNG-------LTLARKLLIPKYGLDYEYEGRKLWEWLLEPTRIYVRPIL-EL 228
G+ SSG+H G L ++ L + +D +G L L PT++YV+ +L L
Sbjct: 620 GLPSSGLHCAGFNEILTQLAASKVNLRERSPVDGGDDGLTLAHVLATPTQLYVQQLLPHL 679
Query: 229 INSVEVHGLAHITGGGLLNLKRLTNYGFELEMP----PIEGIFK-LIHENGVPLDEMFRV 283
E+ +AH+T G L ++ RL GFE + P+ IF L + + +
Sbjct: 680 QKGDEIKSVAHVTHGLLNDILRLLPDGFETTLDFGAVPVPKIFGWLAGKLKLSAQTILER 739
Query: 284 FNMGVGFIVVVPQEEK 299
N G+G ++++PQ +
Sbjct: 740 HNCGIGMVLILPQSSQ 755
>emb|CAA24923.1| (X00041) GART [Drosophila melanogaster]
Length = 1089
Score = 153 bits (382), Expect = 3e-36
Identities = 102/300 (34%), Positives = 165/300 (55%), Gaps = 24/300 (8%)
Query: 56 LAMTTDGVGTKVLVAEAVGKFDTIGIDMIAMNVNDLLCVGAEPLALVDYFAVKEPNEEVF 115
L + TDGVGTK+ +A+ + ++GID++AM VND+LC GAEP++ Y+A E++
Sbjct: 787 LILGTDGVGTKLKIAQQTNRNTSVGIDLVAMCVNDILCNGAEPISFSSYYACGHWQEQLA 846
Query: 116 KQVAKGLYKGAEEAGVAIVGGETAVMPDLING--YDLAGTAIGIVE-KGKVITGERIRPG 172
K V G+ +GA +A + + +A +P L YDLAG A+GI E G + I+PG
Sbjct: 847 KGVHSGVQEGARQANSSFIDSHSAALPLLYEPQVYDLAGFALGIAEHTGILPLLAEIQPG 906
Query: 173 DSVIGISSSGIHSNGLTLARKLLIPKYGLDYE----YEGRKLWEWLLEPTRIYVRPILEL 228
D +IG+ SSG+HSNG +L +L + GL + + L E LL PT+IYV+ + L
Sbjct: 907 DVLIGLPSSGVHSNGFSLVHAVL-KRVGLGLHDKAPFSDKTLGEELLVPTKIYVKALSTL 965
Query: 229 INSVE--VHGLAHITGGGLL-NLKRLTNYGF-------ELEMPPIEGIFKLIHENGVPLD 278
++ + + LAHITGGGL N+ R+ + ++PP+ L +
Sbjct: 966 LSRGKHGIKALAHITGGGLSENIPRVLRKDLAVRLDANKFQLPPV--FAWLAAAGNISST 1023
Query: 279 EMFRVFNMGVGFIVVVPQEEKEEALEILSRHYKSYELGNVTR----ELGKIKVKNYGITL 334
E+ R +N G+G ++VV E E+ L+ L ++ +G V + ++ V+N+ +L
Sbjct: 1024 ELQRTYNCGLGMVLVVAPTEVEDVLKELRYPQRAAVVGEVVARKDPKKSQVVVQNFEASL 1083
Score = 137 bits (341), Expect = 2e-31
Identities = 101/316 (31%), Positives = 162/316 (50%), Gaps = 20/316 (6%)
Query: 2 LTYAQAGVDEEKTARALREIIRTARETFKLRKGKVGEPGDIGHYAAL--LDFGNFYLAMT 59
L+Y +GVD + ++ I +R T R G +G G G L L + +A
Sbjct: 383 LSYKDSGVDIDAGDALVQRIKPLSRGT--QRPGVIGGLGGFGGLFRLKELTYKEPVIAEA 440
Query: 60 TDGVGTKVLVAEAVGKFDTIGIDMIAMNVNDLLCVGAEPLALVDYFAVKEPNEEVFKQVA 119
T GVG K+ +A ++ +G D+ A+ ND+L VGAEP+A +DY A + + Q+
Sbjct: 441 TQGVGAKIHLALTHEFYENVGYDLFALAANDVLEVGAEPVAFLDYIACGKLQVPLAAQLV 500
Query: 120 KGLYKGAEEAGVAIVGGETAVMPDLI--NGYDLAGTAIGIVEKGKVITG-ERIRPGDSVI 176
KG+ G +A A+VGGETA MP L +D+AG +GIVE +++ + +PGD +I
Sbjct: 501 KGMADGCRDARCALVGGETAEMPSLYAPGQHDMAGYCVGIVEHSRILPRFDLYQPGDLLI 560
Query: 177 GISSSGIHSNG-------LTLARKLLIPKYGLDYEYEGRKLWEWLLEPTRIYVRPIL-EL 228
G+ SSG+H G L ++ L + +D +G L L PT++YV+ +L L
Sbjct: 561 GLPSSGLHCAGFNEILTQLAASKVNLRERSPVDGGDDGLTLAHVLATPTQLYVQQLLPHL 620
Query: 229 INSVEVHGLAHITGGGLLNLKRLTNYGFELEMP----PIEGIFK-LIHENGVPLDEMFRV 283
E+ +AH+T G L ++ RL GFE + P+ IF L + + +
Sbjct: 621 QKGDEIKSVAHVTHGLLNDILRLLPDGFETTLDFGAVPVPKIFGWLAGKLKLSAQTILER 680
Query: 284 FNMGVGFIVVVPQEEK 299
N G+G ++++PQ +
Sbjct: 681 HNCGIGMVLILPQSSQ 696
>sp|P16340|PUR2_DROPS TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADENOSINE-3 [INCLUDES:
PHOSPHORIBOSYLAMINE--GLYCINE LIGASE (GARS) (GLYCINAMIDE
RIBONUCLEOTIDE SYNTHETASE) (PHOSPHORIBOSYLGLYCINAMIDE
SYNTHETASE); PHOSPHORIBOSYLFORMYLGLYCINAMIDINE
CYCLO-LIGASE (AIRS) (PHOSPHORI> >gi|68650|pir||AJFFPP
purine synthesis multifunctional protein - fruit fly
(Drosophila pseudoobscura) >gi|295787|emb|CAA29611.1|
(X06285) GARS-AIRS-GART polypeptide [Drosophila
pseudoobscura]
Length = 1364
Score = 148 bits (369), Expect = 1e-34
Identities = 96/278 (34%), Positives = 154/278 (54%), Gaps = 16/278 (5%)
Query: 56 LAMTTDGVGTKVLVAEAVGKFDTIGIDMIAMNVNDLLCVGAEPLALVDYFAVKEPNEEVF 115
L + TDGVGTK+ +A+ + ++GID++AM VND+LC GAEP + Y+A + +
Sbjct: 848 LILGTDGVGTKLKIAQQTHRNASVGIDLVAMCVNDILCNGAEPFSFSSYYACGKWQAALA 907
Query: 116 KQVAKGLYKGAEEAGVAIVGGETAVMPDLING--YDLAGTAIGIVEKGKVITG-ERIRPG 172
+V G+ +GA +A + V +A +P L YDLAG A+GI E+ ++ + I+PG
Sbjct: 908 AEVNAGVQEGASQANSSFVASHSAALPLLYEPQVYDLAGFALGIAERSAILPRLDEIQPG 967
Query: 173 DSVIGISSSGIHSNGLTLARKLLIPKYGLDYE----YEGRKLWEWLLEPTRIYVRPILEL 228
D +IG+ SSG+HSNG +L +L + GL + + L E LL PT+IYV+ + L
Sbjct: 968 DVLIGLPSSGVHSNGFSLVHAVL-KRAGLGLNDRAPFSEKTLGEELLVPTKIYVKALSAL 1026
Query: 229 INSVE--VHGLAHITGGGLL-NLKRLTNYGFELEMP----PIEGIFKLIHENG-VPLDEM 280
++ + LAHITGGGL N+ R+ + + P+ +F + G + E+
Sbjct: 1027 LSRPNHGIKALAHITGGGLSENIPRVLRKELAVRLDANKYPLPPVFAWLAAAGNISSTEL 1086
Query: 281 FRVFNMGVGFIVVVPQEEKEEALEILSRHYKSYELGNV 318
R +N G+G ++VV E + L L ++ +G V
Sbjct: 1087 QRTYNCGLGLVLVVGATEVDGVLRELRYPQRASVVGEV 1124
Score = 137 bits (341), Expect = 2e-31
Identities = 111/355 (31%), Positives = 178/355 (49%), Gaps = 34/355 (9%)
Query: 2 LTYAQAGVDEEKTARALREIIRTARETFKLRKGKVGEPGDIGHYAALLD--FGNFYLAMT 59
L+Y +GVD + ++ I +R T R G +G G G L D + +A
Sbjct: 442 LSYKDSGVDIDAGDALVQRIKPLSRGT--QRPGVLGGLGGFGGLFRLKDLSYKEPVIAEA 499
Query: 60 TDGVGTKVLVAEAVGKFDTIGIDMIAMNVNDLLCVGAEPLALVDYFAVKEPNEEVFKQVA 119
T GVG K+ +A ++ IG D+ AM+ NDLL +GAEP+A +DY A + + + Q+
Sbjct: 500 TQGVGAKIQLALQNELYENIGYDLFAMSANDLLELGAEPVAFLDYIACGKLHVPLAAQLV 559
Query: 120 KGLYKGAEEAGVAIVGGETAVMPDLI--NGYDLAGTAIGIVEKGKVITG-ERIRPGDSVI 176
KG+ G +A A+VGGETA MP L +D+AG +GIVE+ +V+ + P D ++
Sbjct: 560 KGMADGCRDAKCALVGGETAEMPSLYAPGQHDMAGYCVGIVEQARVLPRFDLYEPEDLLV 619
Query: 177 GISSSGIHSNGLT-LARKLLIPKYGLDY------EYEGRKLWEWLLEPTRIYVRPIL-EL 228
G+ SSG+H G + +L K L G L + L PTR+YV+ +L L
Sbjct: 620 GLPSSGLHCAGFNEILTQLAASKVNLKECSPVGGGKHGLSLAQVLGTPTRLYVQQLLPHL 679
Query: 229 INSVEVHGLAHITGGGLLNLKRLTNYGFELEMP----PIEGIFK-LIHENGVPLDEMFRV 283
++ +AH+T G L +++RL GFE+ + P+ +F L + + +
Sbjct: 680 QAGNQIKAVAHVTHGLLHDVQRLLPEGFEVTLDFGAVPVPDVFGWLAGQLQLSAQTLLER 739
Query: 284 FNMGVGFIVVVPQEE--------KEEALEILSRHYKSYELGNVTRELGKIKVKNY 330
N G+G ++V+PQ + L +L+R K+ G R +KV+N+
Sbjct: 740 HNCGIGMVLVLPQSSLLWRTALPGAKVLGVLNRQAKA--SGGAPR----VKVRNF 788
>gb|AAF71922.1| (AF236855) GART-B [Gallus gallus]
Length = 682
Score = 136 bits (338), Expect = 5e-31
Identities = 102/337 (30%), Positives = 164/337 (48%), Gaps = 34/337 (10%)
Query: 24 TARETFKLRKGKVGEPGDIGHYAALLDFGNFY-----------LAMTTDGVGTKVLVAEA 72
T+ F KG + G ++ L F F+ L T G+G K+ +A+A
Sbjct: 90 TSDVLFYQPKGSIVSRTRSGSHSELRGFAGFFDLKASGYDDPILVSQTKGLGPKLQIAQA 149
Query: 73 VGKFDTIGIDMIAMNVNDLLCVGAEPLALVDYFAVKEPNEEVFKQVAKGLYKGAEEAGVA 132
+ DTIG D++A+ VND+L GAEPL + YF+ + + +V + + +G+ + AG A
Sbjct: 150 CKRHDTIGQDLVALCVNDILAQGAEPLFFLTYFSCGKLDVKVTEAIKEGIAEACRNAGCA 209
Query: 133 IVGGETAVMPDLING--YDLAGTAIGIVEKGKVITG-ERIRPGDSVIGISSSGIHSNGLT 189
+G E A + + + YDLAG +G VE+G+++ G +R D IG++SSGIH T
Sbjct: 210 FLGREIAEVTSMYSSGEYDLAGFVVGAVERGQMLLGLQRADEEDVFIGLASSGIHGRAFT 269
Query: 190 LARKLLIPKYGLDYEYEG------RKLWEWLLEPTRIYVRPILELINSVEVHGLAHITGG 243
+ RK+L+ L Y + L + LL P ++Y +L ++ S V A I
Sbjct: 270 IIRKILLVS-SLHYSSPAPGSCGDKTLGDVLLTPAKLYSPSLLPVLRSGHVKSFAFIAEE 328
Query: 244 GLL-NLKRLTNY-------GFELEMPPIEGIFKLIHENGVPLDEMFRVFNMGVGFIVVVP 295
GLL + R+ +MP I L E + EM + FN G+G ++VV
Sbjct: 329 GLLEGISRILPEHVSAVLDALNWKMPEI--FCWLYKEGNLSEKEMAQTFNCGIGAVLVVQ 386
Query: 296 QEEKEEALEILSRHYKSYELGNVTREL---GKIKVKN 329
+E + L + RH +++ +G V IKV+N
Sbjct: 387 KELAQHVLRDVQRHEEAWLIGKVVAPCHTGSHIKVEN 423
>gb|AAA62987.1| (U15182) phosphoribosylformylglycinamidine cyclo-ligase
[Mycobacterium leprae]
Length = 197
Score = 106 bits (262), Expect = 4e-22
Identities = 67/167 (40%), Positives = 96/167 (57%), Gaps = 17/167 (10%)
Query: 2 LTYAQAGVDEEKTARALREIIRTARETFK---LRKGKVGEPGDIGHYAALLDFGNFY--- 55
+TYA GVD E R++ E FK ++ + G +G +A L + Y
Sbjct: 25 ITYASTGVDIEAGDRSV--------ELFKPMAVKAIRTEVLGGLGGFAGLFALRSGYREP 76
Query: 56 -LAMTTDGVGTKVLVAEAVGKFDTIGIDMIAMNVNDLLCVGAEPLALVDYFAVKEPNEEV 114
LA +TDGVGTK+ VA+A+ K T+G+D++AM V+DL+ GAEPL L DY AV E
Sbjct: 77 VLAASTDGVGTKLAVAQAMDKHATVGLDLVAMVVDDLVVCGAEPLFLQDYIAVGRTVPER 136
Query: 115 FKQVAKGLYKGAEEAGVAIVGGETAVMPDL--INGYDLAGTAIGIVE 159
+ G+ +G AG A++GGETA P L ++ YD+A T +G+VE
Sbjct: 137 LSAIVDGIAEGCMLAGCALLGGETAEHPGLMEVDHYDIAATGVGVVE 183
>pir||T40422 phosphoribosylamine--glycine ligase - fission yeast
(Schizosaccharomyces pombe) (fragment)
>gi|4490673|emb|CAB38600.1| (AL035655)
phosphoribosylamine--glycine ligase [Schizosaccharomyces
pombe]
Length = 185
Score = 99.8 bits (245), Expect = 4e-20
Identities = 63/166 (37%), Positives = 98/166 (58%), Gaps = 17/166 (10%)
Query: 167 ERIRPGDSVIGISSSGIHSNGLTLARKLLIPKYGLDYEY-------EGRKLWEWLLEPTR 219
E GD ++G++S G+HSNG +L RK++ +Y D EY + +L + LL PTR
Sbjct: 2 ESFSKGDILLGLASDGVHSNGYSLVRKIV--EYS-DLEYTSVCPWDKNVRLGDSLLIPTR 58
Query: 220 IYVRPILELINSVEVHGLAHITGGGLL-NLKRL----TNYGFELEMPPIEGIFKLIHENG 274
IYV+P+L +I V G+AHITGGGL+ N+ R+ N +++ + +FK + + G
Sbjct: 59 IYVKPLLHVIRKNIVKGMAHITGGGLVENVPRMLPSHLNAIIDVDTWEVPEVFKWLKDAG 118
Query: 275 -VPLDEMFRVFNMGVGFIVVVPQEEKEEAL-EILSRHYKSYELGNV 318
VP+ +M R FNMG+G +V V E+ EE + E+ S Y +G +
Sbjct: 119 NVPISDMARTFNMGIGMVVAVASEDAEETMKELTSVGETVYRIGQL 164
>sp|P40178|PUR5_STRFR PUTATIVE PHOSPHORIBOSYLFORMYLGLYCINAMIDINE CYCLO-LIGASE (AIRS)
(PHOSPHORIBOSYL-AMINOIMIDAZOLE SYNTHETASE) (AIR
SYNTHASE) >gi|499882|gb|AAA62389.1| (L33872) homolog of
E.coli purM gene product [Streptomyces fradiae]
Length = 182
Score = 93.2 bits (228), Expect = 4e-18
Identities = 68/162 (41%), Positives = 87/162 (52%), Gaps = 11/162 (6%)
Query: 169 IRPGDSVIGISSSGIHSNGLTLARKLLIPK--YGLDYEYE--GRKLWEWLLEPTRIYVRP 224
IR GD+VI ++SSG+HSNG +L R +L Y LD E GR L E LLEPTRIY
Sbjct: 1 IRAGDAVIAMASSGLHSNGYSLVRHVLFDGAGYALDREIPEFGRTLGEELLEPTRIYSLD 60
Query: 225 ILELINSVEVHGLAHITGGGLL-NLKRLTNYGFELEMPPI----EGIFKLIHENG-VPLD 278
L L + EVH +HITGGGL NL R+ G + +F L+ G V
Sbjct: 61 CLALTRTTEVHAFSHITGGGLANNLARVIPDGLHATVDRATWTPAPVFGLVGSAGSVERT 120
Query: 279 EMFRVFNMGVGFIVVVPQEEKEEALEILS-RHYKSYELGNVT 319
E+ + NMGVG I VV E + AL L+ R ++ G +T
Sbjct: 121 ELEKTLNMGVGMIAVVAPEGADAALATLADRGVDAWICGEIT 162
>gb|AAB46604.1| (U85779) aminoimidazole ribotide synthetase [Mycobacterium
tuberculosis]
Length = 157
Score = 86.6 bits (211), Expect = 4e-16
Identities = 47/114 (41%), Positives = 69/114 (60%), Gaps = 5/114 (4%)
Query: 63 VGTKVLVAEAVGKFDTIGIDMIAMNVNDLLCVGAEPLALVDYFAVKEPNEEVFKQVAKGL 122
VGTK+ +A+A+ + DT+G+D++AM V+DL+ GAEPL L+DY AV E + G+
Sbjct: 1 VGTKLAIAQAMXEHDTVGLDLVAMVVDDLVVCGAEPLFLLDYIAVGRIVPERLSAIVAGI 60
Query: 123 YKGAEEAGVAIVGGETAVMPDLI--NGYDLAGTAIGIVEKGKVITGERIRPGDS 174
G AG A++GGETA P LI + YD + T +G+ G+ RPG +
Sbjct: 61 ADGCMRAGCALLGGETAEHPGLIEPDHYDFSATGVGVFGGGQCAGS---RPGQT 111
>gb|AAB70813.1| (AF008654) glycinamide ribonucleotide formyltransferase [Homo
sapiens]
Length = 102
Score = 78.0 bits (189), Expect = 1e-13
Identities = 43/99 (43%), Positives = 61/99 (61%), Gaps = 5/99 (5%)
Query: 41 DIGHYAALLD-----FGNFYLAMTTDGVGTKVLVAEAVGKFDTIGIDMIAMNVNDLLCVG 95
D+G +A L D F + LA TDGVGTK+ +A+ K DTIG D++AM VND+L G
Sbjct: 4 DLGGFAGLFDLKAAGFKDPLLASGTDGVGTKLKIAQLCNKHDTIGQDLVAMCVNDILAQG 63
Query: 96 AEPLALVDYFAVKEPNEEVFKQVAKGLYKGAEEAGVAIV 134
AEPL +DYF+ + + V + V G+ K +AG A++
Sbjct: 64 AEPLFFLDYFSCGKLDLSVTEAVVAGIAKACGKAGCALL 102
>gb|AAA62985.1| (U15182) phosphoribosylamine-glycine ligase [Mycobacterium leprae]
Length = 148
Score = 77.6 bits (188), Expect = 2e-13
Identities = 51/121 (42%), Positives = 67/121 (55%), Gaps = 7/121 (5%)
Query: 207 GRKLWEWLLEPTRIYVRPILELINSVEVHGLAHITGGGLL-NLKRLTNYGFELEMP---- 261
GR L E LLEPTRIY + L L V H+TGGGL NL+R+ +G E+
Sbjct: 11 GRTLGEELLEPTRIYAKDCLALAAETHVRTFCHVTGGGLAGNLQRVIPHGLVAEVDRGTW 70
Query: 262 PIEGIFKLIHENG-VPLDEMFRVFNMGVGFIVVVPQEEKEEALEIL-SRHYKSYELGNVT 319
+F +I + G V +EM + FNMGVG I VV E+ + AL IL +RH + LG V
Sbjct: 71 TPAPVFAMIAQRGRVAREEMEKTFNMGVGMIAVVAPEDTDRALAILTARHLDCWVLGTVC 130
Query: 320 R 320
+
Sbjct: 131 K 131
>sp|Q58089|Y676_METJA PUTATIVE HYDROGENASE EXPRESSION/FORMATION PROTEIN MJ0676
>gi|2127980|pir||D64384 hydrogenase expression/formation
protein homolog - Methanococcus jannaschii
>gi|1591391|gb|AAB98671.1| (U67515) hydrogenase
expression/formation protein (hypE) [Methanococcus
jannaschii]
Length = 335
Score = 72.6 bits (175), Expect = 6e-12
Identities = 71/272 (26%), Positives = 129/272 (47%), Gaps = 29/272 (10%)
Query: 46 AALLDFGNFYLAMTTDGVGTKVLVAEAVGKFDTIGIDMIAMNVNDLLCVGAEPLALVDYF 105
+A + G+ + T DG K + IG ++ VNDL +GA+PLAL
Sbjct: 43 SATIPIGDKEIVFTVDGHTVKPIFFPG----GDIGRLAVSGTVNDLAVMGAKPLALSLSL 98
Query: 106 AVKEP-NEEVFKQVAKGLYKGAEEAGVAIVGGETAVMPDLINGYDLAGTAIGIVEKGKVI 164
+ E N E +++ K + + ++EA VAI+ G+T V D ++ ++ IGIV++GK I
Sbjct: 99 IIPEGFNLEDLEKIVKSINETSKEAEVAIITGDTKVS-DGVDDIIISTAGIGIVDRGKAI 157
Query: 165 TGERIRPGDSVIGISSSGIHSNGLTLARKLLIPKYGLDYEYEGRKLWEWLLEPTRIYVRP 224
++ GD++I + G H + L+R+ G D+E + + P +
Sbjct: 158 RDCNVQEGDAIIVSGNIGEHGLAILLSRE------GFDFETNIKS----DVAPINKLIER 207
Query: 225 ILELINSVEVHGLAHITGGGLLN----LKRLTNYG---FELEMPPIEGIFKLIHENGVPL 277
+LE ++++ + T GGL + + +N G FE ++P + + + G+
Sbjct: 208 VLE--EGIQINAMKDPTRGGLADALNEMAEKSNIGITIFEDKIPISDEVQSICDILGL-- 263
Query: 278 DEMFRVFNMGVGFIVVVPQEEKEEALEILSRH 309
+ + N G ++ V +E+ E LEIL H
Sbjct: 264 -DPLTIANEG-KVVMAVKKEDAERCLEILREH 293
>pir||B69125 hydrogenase expression/formation protein HypE - Methanobacterium
thermoautotrophicum (strain Delta H)
>gi|2621250|gb|AAB84711.1| (AE000807) hydrogenase
expression/formation protein HypE [Methanobacterium
thermoautotrophicum]
Length = 376
Score = 69.5 bits (167), Expect = 5e-11
Identities = 66/263 (25%), Positives = 115/263 (43%), Gaps = 32/263 (12%)
Query: 47 ALLDFGNFYLAMTTDGVGTKVLVAEAVGKFDTIGIDMIAMNVNDLLCVGAEPLALVDYFA 106
A + G++ + ++TDG L IG +A VND+ +GA PLA+ +
Sbjct: 84 ASIPLGDYEIVISTDGHTIDPLFFPG----GDIGRIAVAGTVNDISVMGARPLAIANAMI 139
Query: 107 VKE--PNEEVFKQVAKGLYKGAEEAGVAIVGGETAVMPD-LINGYDLAGTAIGIVEKGKV 163
+ E P E++ +++ K + + E GV+IV G+T VM ++ + T IG+V +G+
Sbjct: 140 ISEGFPGEDL-ERIIKSMDAVSRETGVSIVTGDTKVMEQGKLDRMVITTTGIGVVGRGET 198
Query: 164 ITGERIRPGDSVIGISSSGIHSNGLTLARKLLIPKYGLDYEYEGRKLWEWLLEPTRIYVR 223
+ +RPGD +I S G H L R+ +G D + E W +
Sbjct: 199 VRDSGLRPGDKIILTGSVGDHGMALMAFRE----GFGFDTDLESDVAPVWGI-------- 246
Query: 224 PILELINSVEVHGLAHITGGGLLNLKRLTNYGFELEMPPIEGIFKLIHENGVPLDEMFRV 283
+ +N V + T GG+ N EM G+ ++ E+ +P+ E +
Sbjct: 247 -VEAALNVGGVTAMKDPTRGGIANALN--------EMADKSGVGMVLDEDSIPVREEVKA 297
Query: 284 FNMGVGFIVVVPQEEKEEALEIL 306
+ +G + P E E I+
Sbjct: 298 VSEMLG---IDPYEVANEGKVII 317
>gb|AAC26158.1| (AF035751) HypE [Synechococcus PCC7002]
Length = 348
Score = 69.1 bits (166), Expect = 7e-11
Identities = 88/307 (28%), Positives = 134/307 (42%), Gaps = 42/307 (13%)
Query: 37 GEPGDIGHYAALLDFGNFYLAMTTDGVGTKVLVAEA--VGKFDTIGIDMIAMNVNDLLCV 94
GEP H AA L LA TTD + L +GK G VNDL
Sbjct: 39 GEPCT-SHDAAALPVSTEKLAFTTDSYVVQPLFFPGGDIGKLAIYG------TVNDLAMA 91
Query: 95 GAEPLALVDYFAVKE--PNEEVFKQVAKGLYKGAEEAGVAIVGGETAVMP-DLINGYDLA 151
GA PL L F ++E P E ++ QV + + A+ GV IV G+T V+ +G +
Sbjct: 92 GARPLYLSVGFILEEGLPLETLW-QVVVSMQQAAQVVGVQIVTGDTKVVERGKGDGLFIN 150
Query: 152 GTAIGIVEKGKVITGERIRPGDSVIGISSSGIHSNGLTLARKLLIPKYGLDYEYEGRKLW 211
+ IGI+E I + I PGD+++ G H + R+ GL +E
Sbjct: 151 TSGIGIIESRLNIQPKAIAPGDTILVSGDLGRHGIAIMAQRE------GLAFESPIESDC 204
Query: 212 EWLLEPTRIYVRPILELINSVEVHGLAHITGGGL---LN-LKRLTNYGFEL---EMPPIE 264
L+EP + ++ +E+H L IT GGL LN L Y F++ ++P IE
Sbjct: 205 APLVEPVQDLLKA------GIEIHCLRDITRGGLGAVLNELAIAAGYQFKVHGNQIPVIE 258
Query: 265 GIFKLIHENGVPLDEMFRVFNMGVGFIVVVPQEEKEEALEILSRHYKSYELGNVTRELGK 324
+ G + + N G F+ ++P+ E L +L +HY + R++G
Sbjct: 259 AVRGACEIFGF---DPVHIANEG-RFVAILPEARAAEGLALL-QHYNAN-----ARQIGL 308
Query: 325 IKVKNYG 331
+ +N G
Sbjct: 309 VTTQNCG 315
Database: ./suso.pep
Posted date: Jul 6, 2001 5:57 PM
Number of letters in database: 840,471
Number of sequences in database: 2977
Database: /banques/blast2/nr.pep
Posted date: Dec 14, 2000 12:46 PM
Number of letters in database: 188,266,275
Number of sequences in database: 595,510
Lambda K H
0.319 0.142 0.405
Gapped
Lambda K H
0.270 0.0470 0.230
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 125956864
Number of Sequences: 2977
Number of extensions: 5542900
Number of successful extensions: 12740
Number of sequences better than 1.0e-10: 69
Number of HSP's better than 0.0 without gapping: 61
Number of HSP's successfully gapped in prelim test: 8
Number of HSP's that attempted gapping in prelim test: 12438
Number of HSP's gapped (non-prelim): 76
length of query: 334
length of database: 189,106,746
effective HSP length: 55
effective length of query: 279
effective length of database: 156,189,961
effective search space: 43576999119
effective search space used: 43576999119
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 41 (21.7 bits)
S2: 165 (68.7 bits)