BLASTP 2.0.10 [Aug-26-1999]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= PAB1100 (hisS) DE:histidyl-tRNA synthetase (hisS)
(431 letters)
Database: ./suso.pep; /banques/blast2/nr.pep
598,487 sequences; 189,106,746 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
pir||G75017 histidyl-tRNA synthetase (hiss) PAB1100 - Pyrococcus... 858 0.0
sp|O58028|SYH_PYRHO HISTIDYL-TRNA SYNTHETASE (HISTIDINE--TRNA LI... 719 0.0
sp|Q58406|SYH_METJA HISTIDYL-TRNA SYNTHETASE (HISTIDINE--TRNA LI... 334 1e-90
sp|O26346|SYH_METTH HISTIDYL-TRNA SYNTHETASE (HISTIDINE--TRNA LI... 332 7e-90
pir||E69130 histidine--tRNA ligase (EC 6.1.1.21) - Methanobacter... 332 7e-90
gb|AAG20175.1| (AE005094) histidyl-tRNA synthetase; HisS [Haloba... 296 4e-79
gi|11499232 histidyl-tRNA synthetase (hisS) [Archaeoglobus fulgi... 290 2e-77
gb|AAK40617.1| Histidyl-tRNA synthetase (hisS) [Sulfolobus solfa... 278 8e-74
emb|CAC11247.1| (AL445063) probable histidyl-tRNA synthetase [Th... 273 2e-72
pir||T49251 histidine--tRNA ligase (EC 6.1.1.21) precursor, plas... 260 2e-68
sp|Q9YEB2|SYH_AERPE HISTIDYL-TRNA SYNTHETASE (HISTIDINE--TRNA LI... 245 5e-64
sp|P56455|SYH_HELPY HISTIDYL-TRNA SYNTHETASE (HISTIDINE--TRNA LI... 226 3e-58
sp|Q9ZK27|SYH_HELPJ HISTIDYL-TRNA SYNTHETASE (HISTIDINE--TRNA LI... 222 8e-57
emb|CAB93388.1| (AL357523) histidyl tRNA synthetase [Streptomyce... 221 1e-56
sp|Q9X0H5|SYH_THEMA HISTIDYL-TRNA SYNTHETASE (HISTIDINE--TRNA LI... 218 9e-56
sp|O32422|SYH_STAAU HISTIDYL-TRNA SYNTHETASE (HISTIDINE--TRNA LI... 217 2e-55
pdb|1QE0|A Chain A, Crystal Structure Of Apo S. Aureus Histidyl-... 217 2e-55
sp|O66522|SYH_AQUAE HISTIDYL-TRNA SYNTHETASE (HISTIDINE--TRNA LI... 215 1e-54
dbj|BAB04970.1| (AP001511) histidyl-tRNA synthetase [Bacillus ha... 214 1e-54
sp|O32039|SYH_BACSU HISTIDYL-TRNA SYNTHETASE (HISTIDINE--TRNA LI... 213 2e-54
gi|6680167 histidyl tRNA synthetase [Mus musculus] >gi|2501005|s... 203 3e-51
gi|6996014 histidyl tRNA synthetase; histidine tRNA ligase [Homo... 202 6e-51
sp|P30053|SYH_STREQ HISTIDYL-TRNA SYNTHETASE (HISTIDINE--TRNA LI... 202 6e-51
sp|Q50641|SYH_MYCTU HISTIDYL-TRNA SYNTHETASE (HISTIDINE--TRNA LI... 201 1e-50
gb|AAD10241.1| (AF020716) histidyl-tRNA synthetase [Triticum aes... 199 5e-50
gb|AAD10242.1| (AF020717) histidyl-tRNA synthetase [Triticum aes... 196 6e-49
sp|P93422|SYH_ORYSA HISTIDYL-TRNA SYNTHETASE (HISTIDINE--TRNA LI... 194 1e-48
sp|O83647|SYH_TREPA HISTIDYL-TRNA SYNTHETASE (HISTIDINE--TRNA LI... 194 1e-48
gb|AAF26984.1|AC018363_29 (AC018363) putative histidyl tRNA synt... 194 2e-48
pir||S30232 histidine--tRNA ligase (EC 6.1.1.21) - Streptococcus... 192 8e-48
sp|P70076|SYH_FUGRU HISTIDYL-TRNA SYNTHETASE (HISTIDINE--TRNA LI... 191 1e-47
pir||A82586 histidyl-tRNA synthetase XF2222 [imported] - Xylella... 189 5e-47
sp|O51160|SYH_BORBU HISTIDYL-TRNA SYNTHETASE (HISTIDINE--TRNA LI... 189 7e-47
pdb|1HTT|A Chain A, Histidyl-Trna Synthetase >gi|1942450|pdb|1HT... 187 2e-46
sp|P04804|SYH_ECOLI HISTIDYL-TRNA SYNTHETASE (HISTIDINE--TRNA LI... 187 2e-46
sp|Q55653|SYH_SYNY3 HISTIDYL-TRNA SYNTHETASE (HISTIDINE--TRNA LI... 186 5e-46
sp|P56194|SYH_THETH HISTIDYL-TRNA SYNTHETASE (HISTIDINE--TRNA LI... 184 1e-45
gb|AAF48856.1| (AE003509) CG6335 gene product [Drosophila melano... 184 1e-45
sp|P46696|SYH_MYCLE HISTIDYL-TRNA SYNTHETASE (HISTIDINE--TRNA LI... 184 2e-45
emb|CAA19087.1| (AL023591) histidyl-tRNA synthetase [Mycobacteri... 184 2e-45
gi|11465814 histidine tRNA synthetase [Porphyra purpurea] >gi|17... 183 3e-45
gi|6325290 cytoplasmic and mitochondrial histidine tRNA syntheta... 180 4e-44
sp|O52765|SYH_SALTY HISTIDYL-TRNA SYNTHETASE (HISTIDINE--TRNA LI... 179 5e-44
gb|AAA34695.1| (M14048) histidine-tRNA synthetase mitochondrial ... 178 1e-43
pir||SYBYHC histidine--tRNA ligase (EC 6.1.1.21), cytosolic - ye... 178 1e-43
sp|P49590|SYHH_HUMAN HISTIDYL-TRNA SYNTHETASE HOMOLOG (HISTIDINE... 176 3e-43
pir||T24848 hypothetical protein T11G6.1 - Caenorhabditis elegan... 176 3e-43
pir||T40151 histidine-tRNA ligase precursor, mitochondrial - fis... 173 3e-42
pir||G82283 histidyl-tRNA synthetase VC0760 [imported] - Vibrio ... 173 5e-42
pir||G81871 probable histidine--tRNA ligase (EC 6.1.1.21) NMA106... 173 5e-42
sp|O34459|HISZ_BACSU ATP PHOSPHORIBOSYLTRANSFERASE REGULATORY SU... 172 6e-42
sp|P07178|SYH_MESAU HISTIDYL-TRNA SYNTHETASE (HISTIDINE--TRNA LI... 171 1e-41
pir||E83171 histidyl-tRNA synthetase PA3802 [imported] - Pseudom... 171 1e-41
sp|P57375|SYH_BUCAI HISTIDYL-TRNA SYNTHETASE (HISTIDINE--TRNA LI... 171 2e-41
pir||A81150 histidyl-tRNA synthetase NMB0854 [imported] - Neisse... 168 9e-41
sp|Q9ZDL9|SYH_RICPR HISTIDYL-TRNA SYNTHETASE (HISTIDINE--TRNA LI... 168 2e-40
sp|P43823|SYH_HAEIN HISTIDYL-TRNA SYNTHETASE (HISTIDINE--TRNA LI... 165 8e-40
sp|Q9Z7P1|SYH_CHLPN HISTIDYL-TRNA SYNTHETASE (HISTIDINE--TRNA LI... 165 1e-39
sp|P47281|SYH_MYCGE HISTIDYL-TRNA SYNTHETASE (HISTIDINE--TRNA LI... 164 2e-39
dbj|BAA98870.1| (AP002547) histidyl tRNA synthetase [Chlamydophi... 164 2e-39
pir||F81660 histidyl-tRNA synthetase TC0830 [imported] - Chlamyd... 164 2e-39
pir||F75406 histidyl-tRNA synthetase - Deinococcus radiodurans (... 158 1e-37
emb|CAA28956.1| (X05345) histidyl-tRNA synthetase (AA 1-508) [Ho... 156 4e-37
sp|Q55267|HISZ_SYNP7 ATP PHOSPHORIBOSYLTRANSFERASE REGULATORY SU... 155 1e-36
dbj|BAB07303.1| (AP001519) histidyl-tRNA synthetase [Bacillus ha... 155 1e-36
sp|O84547|SYH_CHLTR HISTIDYL-TRNA SYNTHETASE (HISTIDINE--TRNA LI... 154 2e-36
pir||E81347 histidine--tRNA ligase (EC 6.1.1.21) Cj0765c [import... 154 2e-36
pir||C82910 histidyl-tRNA synthetase UU285 [imported] - Ureaplas... 152 8e-36
sp|P74592|HISZ_SYNY3 ATP PHOSPHORIBOSYLTRANSFERASE REGULATORY SU... 140 3e-32
sp|P75069|SYH_MYCPN HISTIDYL-TRNA SYNTHETASE (HISTIDINE--TRNA LI... 138 1e-31
sp|P46220|SYH_SULSH PUTATIVE HISTIDYL-TRNA SYNTHETASE (HISTIDINE... 134 1e-30
pir||T48363 histidyl-tRNA synthetase-like protein - Arabidopsis ... 128 1e-28
sp|P34183|SYH_CAEEL HISTIDYL-TRNA SYNTHETASE (HISTIDINE--TRNA LI... 126 5e-28
gb|AAD14008.1|S68230_1 (S68230) histidyl tRNA synthetase [Caenor... 126 5e-28
pir||S41763 histidine--tRNA ligase (EC 6.1.1.21) - Caenorhabditi... 123 3e-27
sp|O67223|HISZ_AQUAE ATP PHOSPHORIBOSYLTRANSFERASE REGULATORY SU... 120 3e-26
pir||B75394 probable histidyl-tRNA synthetase - Deinococcus radi... 104 3e-21
gb|AAC46133.1| (AF010189) HisX [Pseudomonas stutzeri] 101 2e-20
pir||G83027 conserved hypothetical protein PA4939 [imported] - P... 94 2e-18
sp|Q02147|HISZ_LACLA ATP PHOSPHORIBOSYLTRANSFERASE REGULATORY SU... 94 3e-18
>pir||G75017 histidyl-tRNA synthetase (hiss) PAB1100 - Pyrococcus abyssi
(strain Orsay) >gi|5459095|emb|CAB50581.1| (AJ248288)
histidyl-tRNA synthetase (hisS) [Pyrococcus abyssi]
Length = 431
Score = 858 bits (2192), Expect = 0.0
Identities = 431/431 (100%), Positives = 431/431 (100%)
Query: 1 MIERVKGTRDFLPEEMVKRRWVFEKIREVFETYGFKEVLTPVMEYTKLFQLRSGEEVVKQ 60
MIERVKGTRDFLPEEMVKRRWVFEKIREVFETYGFKEVLTPVMEYTKLFQLRSGEEVVKQ
Sbjct: 1 MIERVKGTRDFLPEEMVKRRWVFEKIREVFETYGFKEVLTPVMEYTKLFQLRSGEEVVKQ 60
Query: 61 LYAFKDKGGRDVALRPDMTSSVARLYVNSFQTAPKPIKWYYIANMFRYEEPQSGRYREFW 120
LYAFKDKGGRDVALRPDMTSSVARLYVNSFQTAPKPIKWYYIANMFRYEEPQSGRYREFW
Sbjct: 61 LYAFKDKGGRDVALRPDMTSSVARLYVNSFQTAPKPIKWYYIANMFRYEEPQSGRYREFW 120
Query: 121 QAGVELIGSDKIEADAEVIALFVDSYLSTGLKDFTVNIGDRVLLDEFAKMLGVKDDIGLM 180
QAGVELIGSDKIEADAEVIALFVDSYLSTGLKDFTVNIGDRVLLDEFAKMLGVKDDIGLM
Sbjct: 121 QAGVELIGSDKIEADAEVIALFVDSYLSTGLKDFTVNIGDRVLLDEFAKMLGVKDDIGLM 180
Query: 181 RIIDKKDKLSQEEFLKALGEFGLDENGIEKVLNLIEIKGKPDDVLPLAEELFTSERAKEE 240
RIIDKKDKLSQEEFLKALGEFGLDENGIEKVLNLIEIKGKPDDVLPLAEELFTSERAKEE
Sbjct: 181 RIIDKKDKLSQEEFLKALGEFGLDENGIEKVLNLIEIKGKPDDVLPLAEELFTSERAKEE 240
Query: 241 ISRLYNLVDILSWYEVDEWIQIDLGIARGFDYYTSIVFEAIVPNDLGIGSIGGGGRYDNL 300
ISRLYNLVDILSWYEVDEWIQIDLGIARGFDYYTSIVFEAIVPNDLGIGSIGGGGRYDNL
Sbjct: 241 ISRLYNLVDILSWYEVDEWIQIDLGIARGFDYYTSIVFEAIVPNDLGIGSIGGGGRYDNL 300
Query: 301 IEVFGGKPTPATGFAIGIERLIPILEWKGLLPELKAGPDVFVIPVGDSRDVATAIVTRLR 360
IEVFGGKPTPATGFAIGIERLIPILEWKGLLPELKAGPDVFVIPVGDSRDVATAIVTRLR
Sbjct: 301 IEVFGGKPTPATGFAIGIERLIPILEWKGLLPELKAGPDVFVIPVGDSRDVATAIVTRLR 360
Query: 361 KAGIRSDIELSGRKLRKALDYANRIGVRLSIIVGKRDLERGVVTIRDLESGNQVEVPVDN 420
KAGIRSDIELSGRKLRKALDYANRIGVRLSIIVGKRDLERGVVTIRDLESGNQVEVPVDN
Sbjct: 361 KAGIRSDIELSGRKLRKALDYANRIGVRLSIIVGKRDLERGVVTIRDLESGNQVEVPVDN 420
Query: 421 VVTKVRELLNQ 431
VVTKVRELLNQ
Sbjct: 421 VVTKVRELLNQ 431
>sp|O58028|SYH_PYRHO HISTIDYL-TRNA SYNTHETASE (HISTIDINE--TRNA LIGASE) (HISRS)
>gi|7437816|pir||C71454 histidine--tRNA ligase (EC
6.1.1.21) - Pyrococcus horikoshii
>gi|3256679|dbj|BAA29362.1| (AP000001) 431aa long
hypothetical histidyl-tRNA synthetase [Pyrococcus
horikoshii]
Length = 431
Score = 719 bits (1837), Expect = 0.0
Identities = 350/431 (81%), Positives = 390/431 (90%)
Query: 1 MIERVKGTRDFLPEEMVKRRWVFEKIREVFETYGFKEVLTPVMEYTKLFQLRSGEEVVKQ 60
MIERVKGTRDFLPE+M KRRWVFEKIREVFE YGFKE+LTPVMEYTKLFQLRSGEEVVKQ
Sbjct: 1 MIERVKGTRDFLPEDMAKRRWVFEKIREVFEAYGFKEILTPVMEYTKLFQLRSGEEVVKQ 60
Query: 61 LYAFKDKGGRDVALRPDMTSSVARLYVNSFQTAPKPIKWYYIANMFRYEEPQSGRYREFW 120
LYAFKDKGGRDV+LRPDMTSSVARLYVNSFQ APKPIKWYYIANMFRYEEPQSGRYREFW
Sbjct: 61 LYAFKDKGGRDVSLRPDMTSSVARLYVNSFQMAPKPIKWYYIANMFRYEEPQSGRYREFW 120
Query: 121 QAGVELIGSDKIEADAEVIALFVDSYLSTGLKDFTVNIGDRVLLDEFAKMLGVKDDIGLM 180
QAGVELIGSDK+EADAEVIALFV+SYLSTGL+DFTVNIGDR+LLDEFA MLGV DDIGLM
Sbjct: 121 QAGVELIGSDKVEADAEVIALFVESYLSTGLRDFTVNIGDRILLDEFAGMLGVSDDIGLM 180
Query: 181 RIIDKKDKLSQEEFLKALGEFGLDENGIEKVLNLIEIKGKPDDVLPLAEELFTSERAKEE 240
RIIDK+DKLSQEEF+ L EFGL E+ IEKVL L+EIKG+PD+VLPLAEELF S++AKEE
Sbjct: 181 RIIDKRDKLSQEEFINLLKEFGLGESEIEKVLELVEIKGRPDNVLPLAEELFKSKKAKEE 240
Query: 241 ISRLYNLVDILSWYEVDEWIQIDLGIARGFDYYTSIVFEAIVPNDLGIGSIGGGGRYDNL 300
IS+LY L D+L WY V +WI+IDLGIARGFDYYTSIVFEAI PN+LGIGSIGGGGRYDNL
Sbjct: 241 ISKLYKLTDLLEWYGVKDWIRIDLGIARGFDYYTSIVFEAISPNELGIGSIGGGGRYDNL 300
Query: 301 IEVFGGKPTPATGFAIGIERLIPILEWKGLLPELKAGPDVFVIPVGDSRDVATAIVTRLR 360
IE+FGGKPTPATGFAIGIERL+PILEWKGL+P+ + GP+VFVIP+ D VA I +LR
Sbjct: 301 IEIFGGKPTPATGFAIGIERLLPILEWKGLIPKPQTGPEVFVIPLKDMEKVAINIAVKLR 360
Query: 361 KAGIRSDIELSGRKLRKALDYANRIGVRLSIIVGKRDLERGVVTIRDLESGNQVEVPVDN 420
+ I++DIELSGRKL KALDYANR+G +L IIVGKRD+ERGVVTIRD+ESG Q V ++
Sbjct: 361 REKIKTDIELSGRKLGKALDYANRVGAKLVIIVGKRDVERGVVTIRDMESGEQYNVSLNE 420
Query: 421 VVTKVRELLNQ 431
+V KV+ LL +
Sbjct: 421 IVDKVKNLLKR 431
>sp|Q58406|SYH_METJA HISTIDYL-TRNA SYNTHETASE (HISTIDINE--TRNA LIGASE) (HISRS)
>gi|2127969|pir||G64424 histidine--tRNA ligase (EC
6.1.1.21) - Methanococcus jannaschii
>gi|1591660|gb|AAB99003.1| (U67542) histidyl-tRNA
synthetase (hisS) [Methanococcus jannaschii]
Length = 416
Score = 334 bits (848), Expect = 1e-90
Identities = 189/426 (44%), Positives = 272/426 (63%), Gaps = 21/426 (4%)
Query: 1 MIERVKGTRDFLPEEMVKRRWVFEKIREVFETYGFKEVLTPVMEYTKLFQLRSGEEVVKQ 60
M ++ +GTRDFLPEEM KRR+V K+REVFE YG+KE+LTP E +L ++GEE+ KQ
Sbjct: 4 MFQKPRGTRDFLPEEMKKRRFVENKLREVFERYGYKEILTPTFESFELIAKKTGEEIRKQ 63
Query: 61 LYAFKDKGGRDVALRPDMTSSVARLYVNSFQTAPKPIKWYYIANMFRYEEPQSGRYREFW 120
LY FKD GGR++ALRP+MTS V R Y+N + KP++ YY AN FRYE PQ+GR+REFW
Sbjct: 64 LYVFKDHGGREMALRPEMTSPVVRFYLNELKNLQKPLRLYYFANCFRYERPQAGRFREFW 123
Query: 121 QAGVELIGSDKIEADAEVIALFVDSYLSTGLKDFTVNIGDRVLLDEFAKMLGV--KDDIG 178
Q G ELIG + ADAEV+ L +D ++ GL DF V+IG +L + V ++++
Sbjct: 124 QMGCELIGCKEPLADAEVLNLAMDGLINIGL-DFDVHIGHLGVLKGVLEKFNVSEEEEVK 182
Query: 179 LMRIIDKKDKLSQEEFLKALGEFGLDENGIEKVLNLIEIKGKPDDVLPLAEELFTSERAK 238
+ R+IDK+D + + +L + L E E + +++ KG + + L E L ++
Sbjct: 183 IRRLIDKEDYDNLKIYLTQI----LGEEKKELIFEILKFKGSREVLDELKEILKDFPKSM 238
Query: 239 EEISRLYNLVDILSWYEVDEWIQIDLGIARGFDYYTSIVFEAIVPNDLGIGSIGGGGRYD 298
E I+ NL +IL + D++ I+LGIARG DYYT +VFE + G I GGGRYD
Sbjct: 239 EAIN---NLEEILEFVIHDKY-TINLGIARGLDYYTGMVFE--IYGKKGAKQICGGGRYD 292
Query: 299 NLIEVFGGKPTPATGFAIGIERLIPILEWKGLLPELKAGPDVFVIPVGDSRDV---ATAI 355
NLIE FGG+PTPA GFA G +R++ ++ + E + +IPV +++ + I
Sbjct: 293 NLIETFGGEPTPAVGFAYGFDRIMMNIDDLDIEEE-----SILIIPVKKDKELIKKSLII 347
Query: 356 VTRLRKAGIRSDIELSGRKLRKALDYANRIGVRLSIIVGKRDLERGVVTIRDLESGNQVE 415
+LRKAG ++E+ GRKLRKALDYAN G + IIVG+++L G VT++D+ +G Q
Sbjct: 348 ADKLRKAGKIVELEIMGRKLRKALDYANSRGFKKVIIVGEKELNEGKVTVKDMITGEQKL 407
Query: 416 VPVDNV 421
+ +D +
Sbjct: 408 IGIDEL 413
>sp|O26346|SYH_METTH HISTIDYL-TRNA SYNTHETASE (HISTIDINE--TRNA LIGASE) (HISRS)
Length = 425
Score = 332 bits (841), Expect = 7e-90
Identities = 189/428 (44%), Positives = 263/428 (61%), Gaps = 11/428 (2%)
Query: 2 IERVKGTRDFLPEEMVKRRWVFEKIREVFETYGFKEVLTPVMEYTKLFQLRSGEEVVKQL 61
I R +GTRDFL EM R+ V +R FETYG+ E+ TP+ E KLF ++SGEEVV Q+
Sbjct: 3 ISRPRGTRDFLFAEMRNRKEVEGVLRRTFETYGYHEIKTPIFEELKLFTVKSGEEVVNQI 62
Query: 62 YAFKDKGGRDVALRPDMTSSVARLYVNSFQTAPKPIKWYYIANMFRYEEPQSGRYREFWQ 121
Y F DKGGR++ALRP++T+ VARLY+N Q PKPIK YY + FRYE PQ+GR+R+FWQ
Sbjct: 63 YHFTDKGGRELALRPELTAPVARLYMNEMQKKPKPIKMYYFGSCFRYERPQAGRFRQFWQ 122
Query: 122 AGVELIGSDKIEADAEVIALFVDSYLSTGLKDFTVNIGDRVLLDEFAKMLGVKDDI--GL 179
G ELIG A+AEVI+L +S GL F V+IG +L + ++ +
Sbjct: 123 FGCELIGGRSPLAEAEVISLASESLHELGLDGFEVHIGHLGILRGILGREEIPSELQDRI 182
Query: 180 MRIIDKKDKLSQEEFLKALGEFGLDENGIEKVLNLIEIKGKPDDVLPLAEELFTSERAKE 239
M +IDK D EE LGE + E ++ LI +G P+ + + E L + E
Sbjct: 183 MGVIDKGD---VEELEALLGEVEVSGESRELLMKLIGTQGGPEVLDDVEEYLGGYSESLE 239
Query: 240 EISRLYNLVDILSWYEVDEWIQIDLGIARGFDYYTSIVFEAIVPNDLGIGSIGGGGRYDN 299
+ LV+ L ++ VD++ ++LGIARG DYYT IVFE VP I GGG Y N
Sbjct: 240 ALEEFRELVETLHYFGVDDY-HVNLGIARGLDYYTGIVFEIYVPELGAQKQICGGGTY-N 297
Query: 300 LIEVFGGKPTPATGFAIGIERLIPILEWKGLLPELKAGPDVFVIPVGDSR-DVATAIVTR 358
L+E FGG+ +TGFA G +RL+ L G+ E DVFVIP+ DS A I
Sbjct: 298 LVETFGGERVESTGFAFGFDRLMNAL---GMDEENMRMVDVFVIPIQDSTVPEAIRITQE 354
Query: 359 LRKAGIRSDIELSGRKLRKALDYANRIGVRLSIIVGKRDLERGVVTIRDLESGNQVEVPV 418
LR AG+ +D+E+SGRKLRKAL +A+ +G R +++ G+R+++ G VT++D+E +Q +P
Sbjct: 355 LRAAGVSADLEVSGRKLRKALSHADNLGARFAVLTGEREIQDGKVTVKDMERNSQETLPR 414
Query: 419 DNVVTKVR 426
D +V K++
Sbjct: 415 DEMVDKIK 422
>pir||E69130 histidine--tRNA ligase (EC 6.1.1.21) - Methanobacterium
thermoautotrophicum (strain Delta H)
>gi|2621293|gb|AAB84750.1| (AE000811) histidyl-tRNA
synthetase [Methanobacterium thermoautotrophicum]
Length = 444
Score = 332 bits (841), Expect = 7e-90
Identities = 189/428 (44%), Positives = 263/428 (61%), Gaps = 11/428 (2%)
Query: 2 IERVKGTRDFLPEEMVKRRWVFEKIREVFETYGFKEVLTPVMEYTKLFQLRSGEEVVKQL 61
I R +GTRDFL EM R+ V +R FETYG+ E+ TP+ E KLF ++SGEEVV Q+
Sbjct: 22 ISRPRGTRDFLFAEMRNRKEVEGVLRRTFETYGYHEIKTPIFEELKLFTVKSGEEVVNQI 81
Query: 62 YAFKDKGGRDVALRPDMTSSVARLYVNSFQTAPKPIKWYYIANMFRYEEPQSGRYREFWQ 121
Y F DKGGR++ALRP++T+ VARLY+N Q PKPIK YY + FRYE PQ+GR+R+FWQ
Sbjct: 82 YHFTDKGGRELALRPELTAPVARLYMNEMQKKPKPIKMYYFGSCFRYERPQAGRFRQFWQ 141
Query: 122 AGVELIGSDKIEADAEVIALFVDSYLSTGLKDFTVNIGDRVLLDEFAKMLGVKDDI--GL 179
G ELIG A+AEVI+L +S GL F V+IG +L + ++ +
Sbjct: 142 FGCELIGGRSPLAEAEVISLASESLHELGLDGFEVHIGHLGILRGILGREEIPSELQDRI 201
Query: 180 MRIIDKKDKLSQEEFLKALGEFGLDENGIEKVLNLIEIKGKPDDVLPLAEELFTSERAKE 239
M +IDK D EE LGE + E ++ LI +G P+ + + E L + E
Sbjct: 202 MGVIDKGD---VEELEALLGEVEVSGESRELLMKLIGTQGGPEVLDDVEEYLGGYSESLE 258
Query: 240 EISRLYNLVDILSWYEVDEWIQIDLGIARGFDYYTSIVFEAIVPNDLGIGSIGGGGRYDN 299
+ LV+ L ++ VD++ ++LGIARG DYYT IVFE VP I GGG Y N
Sbjct: 259 ALEEFRELVETLHYFGVDDY-HVNLGIARGLDYYTGIVFEIYVPELGAQKQICGGGTY-N 316
Query: 300 LIEVFGGKPTPATGFAIGIERLIPILEWKGLLPELKAGPDVFVIPVGDSR-DVATAIVTR 358
L+E FGG+ +TGFA G +RL+ L G+ E DVFVIP+ DS A I
Sbjct: 317 LVETFGGERVESTGFAFGFDRLMNAL---GMDEENMRMVDVFVIPIQDSTVPEAIRITQE 373
Query: 359 LRKAGIRSDIELSGRKLRKALDYANRIGVRLSIIVGKRDLERGVVTIRDLESGNQVEVPV 418
LR AG+ +D+E+SGRKLRKAL +A+ +G R +++ G+R+++ G VT++D+E +Q +P
Sbjct: 374 LRAAGVSADLEVSGRKLRKALSHADNLGARFAVLTGEREIQDGKVTVKDMERNSQETLPR 433
Query: 419 DNVVTKVR 426
D +V K++
Sbjct: 434 DEMVDKIK 441
>gb|AAG20175.1| (AE005094) histidyl-tRNA synthetase; HisS [Halobacterium sp. NRC-1]
Length = 432
Score = 296 bits (749), Expect = 4e-79
Identities = 165/422 (39%), Positives = 247/422 (58%), Gaps = 10/422 (2%)
Query: 1 MIERVKGTRDFLPEEMVKRRWVFEKIREVFETYGFKEVLTPVMEYTKLFQLRSGEEVVKQ 60
M +R+KG RDF P EM RR + I + +YGF+EV TP ME T+++ +SG E+V +
Sbjct: 1 MYDRLKGFRDFYPAEMGPRRAAIDAIEDAAASYGFREVGTPAMERTEMYVDKSGAEIVDE 60
Query: 61 LYAFKDKGGRDVALRPDMTSSVARLYVNSFQTAPKPIKWYYIANMFRYEEPQSGRYREFW 120
LY+F D+GGRDVAL P++T +VAR+ V Q KPIKWY +RYEEPQ GR+REF+
Sbjct: 61 LYSFTDQGGRDVALTPELTPTVARMVVAKQQALSKPIKWYSSRPFWRYEEPQQGRFREFY 120
Query: 121 QAGVELIGSDKIEADAEVIALFVDSYLSTGL--KDFTVNIGDRVLLDE-FAKMLGVKDDI 177
Q +++ G+ ADAEV+A+ D S GL DF + R +L A D
Sbjct: 121 QTNLDIFGTSDPRADAEVLAVAADGLTSLGLTGADFEFRVSHRDILGGLLAAFDATVDTE 180
Query: 178 GLMRIIDKKDKLSQEEFLKALGEFGLDENGIEKVLNLIEIKGKPDDVLPLAEELFTSERA 237
+R +DK++K+ + +L L GL + E+ +L++ D L ++R
Sbjct: 181 AAIRTVDKREKIERAAYLDDLAAAGLSYDQAEQFDDLLD-----GDDLDALVSFAGTDRV 235
Query: 238 KEEISRLYNLVDILSWYEVDEWIQIDLGIARGFDYYTSIVFEAI-VPNDLGIGSIGGGGR 296
++ ++ L N++D V ++ + L ARG DYYT +VFE D+G ++ GGGR
Sbjct: 236 RDAVANLRNVLDAAETLGVRQYCDVSLTTARGLDYYTGVVFECFDSTGDVG-RAVFGGGR 294
Query: 297 YDNLIEVFGGKPTPATGFAIGIERLIPILEWKGLLPELKAGPDVFVIPVGDSRDVATAIV 356
YD+LIE FGG+PTPA G A G L +LE G+LP+ + PD +V+ VGD+ A +
Sbjct: 295 YDDLIERFGGQPTPAVGVAPGHATLNLLLENAGVLPDDEFTPDYYVLQVGDTDAEAADVA 354
Query: 357 TRLRKAGIRSDIELSGRKLRKALDYANRIGVRLSIIVGKRDLERGVVTIRDLESGNQVEV 416
+ LR+ G R D +++GR ++YA+ +G +IVG++DL G VTI+++ SG Q
Sbjct: 355 SALRERGNRVDTDITGRSFGAQMNYADNVGADTVVIVGEQDLADGNVTIKNMASGEQTTA 414
Query: 417 PV 418
P+
Sbjct: 415 PI 416
>gi|11499232 histidyl-tRNA synthetase (hisS) [Archaeoglobus fulgidus]
>gi|3334353|sp|O28631|SYH_ARCFU HISTIDYL-TRNA SYNTHETASE
(HISTIDINE--TRNA LIGASE) (HISRS) >gi|7428492|pir||A69455
histidyl-tRNA synthetase (hisS) homolog - Archaeoglobus
fulgidus >gi|2648908|gb|AAB89600.1| (AE000989)
histidyl-tRNA synthetase (hisS) [Archaeoglobus fulgidus]
Length = 409
Score = 290 bits (735), Expect = 2e-77
Identities = 165/417 (39%), Positives = 254/417 (60%), Gaps = 22/417 (5%)
Query: 2 IERVKGTRDFLPEEMVKRRWVFEKIREVFETYGFKEVLTPVMEYTKLFQLRSGEEVVKQL 61
IER +GTRDFLP+EM +RR + +++R++ E++G++EV TP EY +LF +SGE +++++
Sbjct: 3 IERPRGTRDFLPDEMERRREIEKRMRKIAESFGYREVATPTFEYLELFTRKSGEGIIEEM 62
Query: 62 YAFKDKGGRDVALRPDMTSSVARLYVNSFQTAPKPIKWYYIANMFRYEEPQSGRYREFWQ 121
Y FKDK GRD+ALRP++T+ V R++VN PKP+++YY AN FRYE PQ GRYREFWQ
Sbjct: 63 YVFKDKSGRDLALRPELTAPVMRMFVNECSVMPKPLRFYYFANCFRYERPQKGRYREFWQ 122
Query: 122 AGVELIGSDKIEADAEVIALFVDSYLSTGLKDFTVNIGDRVLLDEFAKMLGVKDDIGLMR 181
GVELIGS+ ADAEVI L D L +F++ IG ++ K +G +MR
Sbjct: 123 FGVELIGSESYLADAEVIIL-ADKILKDVGVNFSLEIGHVGIMRHLLKPIGEDRASKVMR 181
Query: 182 IIDKKDKLSQEEFLKALGEFGLDENGIEKVLNLIEIKGKPDDVLPLAEELFTSERAKEEI 241
+IDK D+ E + L E ++E+ +K+ +L+E+KG + V+ A+E+ +
Sbjct: 182 LIDKGDREGLESY---LAEIRVNEDLRDKIFSLLELKG-DESVIEEAKEII-----DYDF 232
Query: 242 SRLYNLVDILSWYEVDEWIQIDLGIARGFDYYTSIVFEAIVPNDLGIGSIGGGGRYDNLI 301
L +L +L VD ++LGIARG DYYT +VFE + GGG Y+ L
Sbjct: 233 GHLESLSALLRDVGVD--FTLNLGIARGLDYYTGVVFECYAEGLGAQKQVCGGGSYE-LS 289
Query: 302 EVFGGKPTPATGFAIGIERLIPILEWKGLLPELKAGPD--VFVIPVGDSRDVATAIVTRL 359
+FGG TP+TGFAIG +R+ ++AG V V+ A + + L
Sbjct: 290 SLFGGPVTPSTGFAIGFDRVCEAC-------SVEAGEKSVVAVVSFKGLESQAFRVASML 342
Query: 360 RKAGIRSDIELSGRKLRKALDYANRIGVRLSIIVGKRDLERGVVTIRDLESGNQVEV 416
R+ G + +++ GR L+K + +A+ +GV+ ++I+G +++ G V I++LE+ QV V
Sbjct: 343 RERGFTAVVDVMGRNLKKQMSFASEMGVKYAVILGPDEVKSGRVAIKNLETQEQVVV 399
>gb|AAK40617.1| Histidyl-tRNA synthetase (hisS) [Sulfolobus solfataricus]
Length = 426
Score = 278 bits (704), Expect = 8e-74
Identities = 164/434 (37%), Positives = 256/434 (58%), Gaps = 19/434 (4%)
Query: 3 ERVKGTRDFLPEEMVKRRWVFEKIREVFETYGFKEVLTPVMEYTKLFQLRSGEEVVKQLY 62
E V+G +D++ + K R++ R++ + YG+ E++TPV+E KLF+L+ GEE+ + +Y
Sbjct: 5 ETVRGMKDYIGIDAEKIRYLESTFRDLAKKYGYSEIITPVVEEFKLFELKGGEELRQTMY 64
Query: 63 AFKDKGGRDVALRPDMTSSVARLYVNSFQTAPKPIKWYYIANMFRYEEPQSGRYREFWQA 122
FKDK R+++LRP++T SVAR Y+ + Q++PKPI+ +Y ++RY+EPQ GRYREF QA
Sbjct: 65 VFKDKADREISLRPEITPSVARAYIQNLQSSPKPIRLFYFGTVYRYDEPQYGRYREFRQA 124
Query: 123 GVELIGSDKIEADAEVIALFVDSYLSTGL-KDFTVNIGDRVLLDEFAKMLGVKDDIGLMR 181
G+E+IG I AD EV+ L + Y L KD T+ I + + + ++D++
Sbjct: 125 GIEMIGDSSILADVEVLDLLYNFYDKLNLSKDITIKINNIGIFRKIMDKYNIEDNL-QEH 183
Query: 182 IIDKKDKLSQEEFLKALGEFGLDENGIEKVLNLIEIK--GKPDDVLPLAE-ELFTSERAK 238
++ DK +E L L E + I LN+I K K +D+ LAE E + K
Sbjct: 184 VLHLIDKNKVDEALVIL-EKNIKNKDIMDFLNMILTKKEAKLEDIESLAELEEVSKLDIK 242
Query: 239 EEISRLYNLVDILSWYEVDEWIQIDLGIARGFDYYTSIVFEAIVPNDLGIGSIGGGGRYD 298
E L L ILS V ++DLG RG YYT ++FE + P+ SI GGGRYD
Sbjct: 243 NEFEYLLRLSRILSSLNVK--FKVDLGFVRGLAYYTGLIFEVLHPSVQ--FSIAGGGRYD 298
Query: 299 NLIEVFGGKPTPATGFAIGIERLIPILEWKGLLPELKAGPDVFVIPVGDSRDVATAIVT- 357
LIE++GG P+PA GFAIG+ER + +++ +LK + VI VG S + A+ T
Sbjct: 299 KLIELYGGLPSPAIGFAIGVERTLLVIK------DLKVEEPINVIVVGISEEAIPAMFTV 352
Query: 358 --RLRKAGIRSDIELSGRKLRKALDYANRIGVRLSIIVGKRDLERGVVTIRDLESGNQVE 415
LRK + I + L K L Y G +L+II+GK++LE+ ++T+R+L + Q+
Sbjct: 353 SRMLRKEEYKVVINTKDQPLSKLLPYYASQGFKLAIIIGKQELEKNMITVRNLITRKQIS 412
Query: 416 VPVDNVVTKVRELL 429
+P++NV+ +++ L
Sbjct: 413 IPLENVLDAIKQTL 426
>emb|CAC11247.1| (AL445063) probable histidyl-tRNA synthetase [Thermoplasma
acidophilum]
Length = 426
Score = 273 bits (692), Expect = 2e-72
Identities = 156/423 (36%), Positives = 248/423 (57%), Gaps = 12/423 (2%)
Query: 2 IERVKGTRDFLPEEMVKRRWVFEKIREVFETYGFKEVLTPVMEYTKLFQLRSGEEVVKQL 61
IE+++G RDF PE+M +++F+ E E +GF+ + P +EY L++++SGEE+++Q
Sbjct: 6 IEKIRGFRDFYPEDMDVEKFIFKTAEEAAEAFGFRRIDFPSLEYLDLYRIKSGEELLQQT 65
Query: 62 YAFKDKGGRDVALRPDMTSSVARLYVNSFQTAPKPIKWYYIANMFRYEEPQSGRYREFWQ 121
Y+F DKGGR+V L P+ T S R+ V S + +P++WY ++RYEEPQ+GRYRE +Q
Sbjct: 66 YSFVDKGGREVTLIPEATPSTVRM-VTSRKDLQRPLRWYSFPKVWRYEEPQAGRYREHYQ 124
Query: 122 AGVELIGSDKIEADAEVIALFVDSYLSTGLKD-FTVNIGDRVLLDEFAKMLGVKDDIGLM 180
++ GSD EADAEVIAL GL+D + + I R +++E + D +
Sbjct: 125 FNADIFGSDSPEADAEVIALASSILDRLGLQDIYEIRINSRKIMEEIIGGMTSSDPFSVF 184
Query: 181 RIIDKKDKLSQEEFLKALGEFGLDENGIEKVLNLIEIKGKPDDVLPLAEELFTSERAKEE 240
IID+ K+S+EEF+ L G+ E+G+ + +L D++ + + ++ EE
Sbjct: 185 SIIDRYHKISREEFVDQLRSAGIGEDGVSMIADLCSGTRGIDEMARI------TGKSSEE 238
Query: 241 ISRLYNLVDILSWYEVDEWIQIDLGIARGFDYYTSIVFEAIVPNDLGIGSIGGGGRYDNL 300
I+R+ + D+L+ Y V ++ D I RG YYT IVFEA +I GGGRYDNL
Sbjct: 239 IARMAAVEDLLASYGVKN-VRYDFSIVRGLSYYTGIVFEA-YDRSGQFRAILGGGRYDNL 296
Query: 301 IEVFGGKPTPATGFAIGIERLIPILEWKGLLPELKAGPDVFVIPVGD-SRDVATAIVTRL 359
+ G+ PA GF +G + +I +L + + + V++ VG + + +L
Sbjct: 297 ASLMSGESVPAVGFGMG-DAVISLLLKRENVQIPREKKSVYICRVGKINSSIMNEYSRKL 355
Query: 360 RKAGIRSDIELSGRKLRKALDYANRIGVRLSIIVGKRDLERGVVTIRDLESGNQVEVPVD 419
R+ G+ +E+ R L L YA+ IG ++I G+RDLERGVVTIR++ +G+Q V +D
Sbjct: 356 RERGMNVTVEIMERGLSAQLKYASAIGADFAVIFGERDLERGVVTIRNMYTGSQENVGLD 415
Query: 420 NVV 422
+VV
Sbjct: 416 SVV 418
>pir||T49251 histidine--tRNA ligase (EC 6.1.1.21) precursor, plastid
[similarity] - Arabidopsis thaliana
>gi|3659909|gb|AAC61600.1| (AF020715) histidyl-tRNA
synthetase [Arabidopsis thaliana]
>gi|7798998|emb|CAB90937.1| (AL355775) histidyl-tRNA
synthetase [Arabidopsis thaliana]
Length = 486
Score = 260 bits (658), Expect = 2e-68
Identities = 153/421 (36%), Positives = 231/421 (54%), Gaps = 13/421 (3%)
Query: 6 KGTRDFLPEEMVKRRWVFEKIREVFETYGFKEVLTPVMEYTKLFQLRSGEEVVKQLYAFK 65
KGTRDF PE+M R W+F +EV YG++EV PV+E LF ++GEE+ QLY F+
Sbjct: 73 KGTRDFPPEDMRLRNWLFNHFKEVSRLYGYEEVDYPVLETEALFIRKAGEEIRDQLYCFE 132
Query: 66 DKGGRDVALRPDMTSSVARLYVNSFQTAPKPIKWYYIANMFRYEEPQSGRYREFWQAGVE 125
D+G R VALRP++T S+ARL + ++ P+KW+ I +RYE GR RE +Q ++
Sbjct: 133 DRGNRRVALRPELTPSLARLVIQKGKSVSLPLKWFAIGQCWRYERMTRGRRREHYQWNMD 192
Query: 126 LIGSDKIEADAEVIALFVDSYLSTGL--KDFTVNIGDRVLLDEFAKMLGVKDDI--GLMR 181
+IG ++ A+AE+I+ V + G+ D + R +L E K GV +D+ +
Sbjct: 193 IIGVPQVTAEAELISSIVTFFKRIGITASDVGFKVSSRKVLQELLKKYGVPEDLFGRVCI 252
Query: 182 IIDKKDKLSQEEFLKALGEFGLDENGIEKVLNLIEIKGKPDDVLPLAEELFTSERAKEEI 241
IIDK +K+ +E K LG G+ E+ IE++L ++ +K D E++ A E I
Sbjct: 253 IIDKIEKIPIDEIKKELGFTGISEDAIEQLLQVLSVKSLDD-----LEDIIGG--AGEAI 305
Query: 242 SRLYNLVDILSWYEVDEWIQIDLGIARGFDYYTSIVFEAIVPNDLGIGSIGGGGRYDNLI 301
+ L L + + EWIQ D + RG YYT IVFE + +I GGGRYD L+
Sbjct: 306 ADLKQLFSLAEKFGYSEWIQFDASVVRGLAYYTGIVFEGF-DRKGKLRAICGGGRYDRLL 364
Query: 302 EVFGGKPTPATGFAIGIERLIPILEWKGLLPELKAGPDVFVIPVG-DSRDVATAIVTRLR 360
+GG PA GF G ++ +L+ K LLPEL + V + D + A + T LR
Sbjct: 365 STYGGDDFPACGFGFGDAVIVELLKEKDLLPELGQEVENIVCALDKDLQGAAATVATALR 424
Query: 361 KAGIRSDIELSGRKLRKALDYANRIGVRLSIIVGKRDLERGVVTIRDLESGNQVEVPVDN 420
G D+ L + L+ A R+ R ++VGK + E G V+++ L SG Q +V + +
Sbjct: 425 DKGQTVDLVLESKPLKWVFKRAARVNARRLVLVGKTEWEDGSVSVKVLSSGEQFQVKLSD 484
Query: 421 V 421
+
Sbjct: 485 L 485
>sp|Q9YEB2|SYH_AERPE HISTIDYL-TRNA SYNTHETASE (HISTIDINE--TRNA LIGASE) (HISRS)
>gi|7437814|pir||B72654 probable histidyl-tRNA
synthetase APE0662 - Aeropyrum pernix (strain K1)
>gi|5104319|dbj|BAA79634.1| (AP000060) 438aa long
hypothetical histidyl-tRNA synthetase [Aeropyrum pernix]
Length = 438
Score = 245 bits (620), Expect = 5e-64
Identities = 156/431 (36%), Positives = 242/431 (55%), Gaps = 14/431 (3%)
Query: 6 KGTRDFLPEEMVKRRWVFEKIREVFETYGFKEVLTPVMEYTKLFQLRSGEEVVKQL-YAF 64
+G RDF PE M+ R+ + ++ VFE+YGF + TP +EY + + GEE +L + F
Sbjct: 13 RGFRDFPPEVMILRKRLLSRLERVFESYGFDPLDTPAVEYWETLSGKYGEEAESRLIWRF 72
Query: 65 KDK-GGRDVALRPDMTSSVARLYVNSFQTAPKPIKWYYIANMFRYEEPQSGRYREFWQAG 123
+D GR ALR D+T +AR +V S P P K Y+I ++R+EEPQ GRYREF Q
Sbjct: 73 QDPWSGRWYALRYDLTVPLAR-FVASNPGLPMPFKRYHIGKVWRHEEPQKGRYREFVQCD 131
Query: 124 VELIGSDKIEADAEVIALFVDSYLSTGLKDFTVNIGDRVLL-DEFAKMLGVKDDIGLMRI 182
+++GS EADAE+++L VDS + GL F V + DR LL F + LG + + + R
Sbjct: 132 ADIVGSPYPEADAEIVSLAVDSIDALGLPGFRVRVNDRRLLAGVFEEELGFDNPLPIYRA 191
Query: 183 IDKKDKLSQEEFLKALGEFGLDENGIEKVLNLIEIKGKPDDVLPLAEELF-TSERAKEEI 241
IDK DK+ E + L GL + +E+++ +I +G+P +VL + ++E+ +E +
Sbjct: 192 IDKLDKIGVEGVRRELERLGLPGSTVERIMEIISWRGRPGEVLESVRRGYGSNEKVREAL 251
Query: 242 SRLYNLVDILSWYEVDEWIQIDLGIARGFDYYTSIVFEAIVPNDLGIGSIGGGGRYDNLI 301
L ++ + D+ +++D+ + RG DYYT + E +V ++ IGS+ GGGRYD L+
Sbjct: 252 DHLEEMLSLAD----DKRVELDMSLVRGLDYYTGPILE-VVLDEPRIGSVAGGGRYDGLV 306
Query: 302 EVFGGKPTPATGFAIGIERLIPI-LEWKGLLPELKAGPDVFVIPVGDSR--DVATAIVTR 358
+F G+ PATG +IGIER+I LE ++K V V+ V D R A
Sbjct: 307 GMFAGRDIPATGVSIGIERIIDAGLELGVYSLDVKTVAQVAVV-VLDRRYYRYAWEAARI 365
Query: 359 LRKAGIRSDIELSGRKLRKALDYANRIGVRLSIIVGKRDLERGVVTIRDLESGNQVEVPV 418
LR+ G+ I+LS + A+R+G+ + VG ++ E G +T+ G +V VP+
Sbjct: 366 LRRGGLNVRIDLSRASGQVQRRKASRLGIPVLAFVGAKEAEGGFLTLYSAAKGERVAVPL 425
Query: 419 DNVVTKVRELL 429
V V LL
Sbjct: 426 GEAVKAVERLL 436
>sp|P56455|SYH_HELPY HISTIDYL-TRNA SYNTHETASE (HISTIDINE--TRNA LIGASE) (HISRS)
>gi|7428493|pir||F64668 histidine--tRNA ligase (EC
6.1.1.21) - Helicobacter pylori (strain 26695)
>gi|2314351|gb|AAD08236.1| (AE000625) histidyl-tRNA
synthetase (hisS) [Helicobacter pylori 26695]
Length = 442
Score = 226 bits (571), Expect = 3e-58
Identities = 138/420 (32%), Positives = 225/420 (52%), Gaps = 13/420 (3%)
Query: 5 VKGTRDFLPEEMVKRRWVFEKIREVFETYGFKEVLTPVMEYTKLFQLRSGEEVVKQLYAF 64
+ G +D LP++ +++ + K+ VF+++GF + TP +EY + + ++ K++Y F
Sbjct: 7 LSGFKDRLPKDAIQKAQLLAKVSVVFQSFGFVPIETPHLEYAQTLLPDASSDIQKEIYRF 66
Query: 65 KDKGGRDVALRPDMTSSVARLYVNSFQTAPKPIKWYYIANMFRYEEPQSGRYREFWQAGV 124
KD G RDVALR D+T +AR QT P K Y I N+FR E Q GRYREF Q
Sbjct: 67 KDHGDRDVALRFDLTVPLARFVSLHHQTLGMPFKRYAIGNVFRGERAQKGRYREFTQCDF 126
Query: 125 ELIGSDKIEADAEVIALFVDSYLSTGLKDFTVNIGDRVLLDEFAKMLGVKDDIGLMRIID 184
+ IGS+ + DAE+I + V S + L+DF V+I R +L+ + G+ +RI+D
Sbjct: 127 DFIGSESLVCDAEIIQVIVASLKALDLEDFCVSINHRKILNGICEYFGISQVNEALRIVD 186
Query: 185 KKDKLS----QEEFLKALGEFGLDENGIEKVLNLIEIKGKPDDVLPLAEELF----TSER 236
K +K+ +EE K E GL+ N I+++L LI+IK E++ +E
Sbjct: 187 KLEKIGLNGVEEELKK---ECGLNSNTIKELLELIQIKQNDLSHAEFFEKIAYLKDYNEN 243
Query: 237 AKEEISRLYNLVDILSWYEVDEWI-QIDLGIARGFDYYTSIVFEAIVPNDLGIGSIGGGG 295
K+ I L L +L ++ + + +ID IARG YYT IV+E + +GS+ GG
Sbjct: 244 LKKGIQDLERLYQLLGDLQISQNLYKIDFSIARGLGYYTGIVYETTLNEMKSLGSVCSGG 303
Query: 296 RYDNLIEVFGGKPTPATGFAIGIERLIPILEWKGLLPELKAGPDVFVIPVGDSR-DVATA 354
RYD+L + F + G +IGI+RLI L LL E V + + + A
Sbjct: 304 RYDHLTKNFSKENLQGVGASIGIDRLIVALSEMQLLDERSTQAKVLIACMHEEYFSYANR 363
Query: 355 IVTRLRKAGIRSDIELSGRKLRKALDYANRIGVRLSIIVGKRDLERGVVTIRDLESGNQV 414
+ LR++GI S++ +K++K YAN G ++G+ + + ++++++ SG Q+
Sbjct: 364 LAESLRQSGIFSEVYPEAQKIKKPFSYANHKGHEFVAVIGEEEFKSETLSLKNMHSGMQL 423
>sp|Q9ZK27|SYH_HELPJ HISTIDYL-TRNA SYNTHETASE (HISTIDINE--TRNA LIGASE) (HISRS)
>gi|7437812|pir||D71847 histidine--tRNA ligase (EC
6.1.1.21) - Helicobacter pylori (strain J99)
>gi|4155714|gb|AAD06696.1| (AE001539) HISTIDYL-TRNA
SYNTHETASE [Helicobacter pylori J99]
Length = 442
Score = 222 bits (559), Expect = 8e-57
Identities = 134/420 (31%), Positives = 224/420 (52%), Gaps = 13/420 (3%)
Query: 5 VKGTRDFLPEEMVKRRWVFEKIREVFETYGFKEVLTPVMEYTKLFQLRSGEEVVKQLYAF 64
+ G +D LP++ +++ + K+ VF+++GF + TP +EY + + ++ K++Y F
Sbjct: 7 LSGFKDRLPKDAIQKAQLLAKVSVVFQSFGFVPIETPHLEYAQTLLPDASSDIQKEIYRF 66
Query: 65 KDKGGRDVALRPDMTSSVARLYVNSFQTAPKPIKWYYIANMFRYEEPQSGRYREFWQAGV 124
KD G RDVALR D+T +AR Q P K Y I N+FR E Q GRYREF Q
Sbjct: 67 KDHGDRDVALRFDLTVPLARFVSLHHQILGMPFKRYAIGNVFRGERAQKGRYREFTQCDF 126
Query: 125 ELIGSDKIEADAEVIALFVDSYLSTGLKDFTVNIGDRVLLDEFAKMLGVKDDIGLMRIID 184
+ IGS+ + DAE+I + + S + L+DF V+I R +L+ + G+ ++RI+D
Sbjct: 127 DFIGSESLVCDAEIIQVIIASLKALDLEDFCVSINHRKILNGICEYFGIAQVNEVLRIVD 186
Query: 185 KKDKLS----QEEFLKALGEFGLDENGIEKVLNLIEIKGKPDDVLPLAEELF----TSER 236
K +K+ +EE K E LD N I+ +L +++IK E++ +E
Sbjct: 187 KLEKIGLNGVEEELKK---ECDLDSNTIKDLLEMVQIKQNDLSHAEFFEKIAYLKDYNEN 243
Query: 237 AKEEISRLYNLVDILSWYEVDEWI-QIDLGIARGFDYYTSIVFEAIVPNDLGIGSIGGGG 295
K+ I L L +L ++ + + +ID IARG YYT IV+E + + +GS+ GG
Sbjct: 244 LKKGIQDLERLYQLLGDLQISQNLYKIDFSIARGLGYYTGIVYETTLNDMKSLGSVCSGG 303
Query: 296 RYDNLIEVFGGKPTPATGFAIGIERLIPILEWKGLLPELKAGPDVFVIPVGDSR-DVATA 354
RYD+L + F + G +IGI+RLI L LL E V + + + A
Sbjct: 304 RYDHLTKNFSKENLQGVGASIGIDRLIVALSEMQLLDERSTQAKVLIACMHEEYFSYANR 363
Query: 355 IVTRLRKAGIRSDIELSGRKLRKALDYANRIGVRLSIIVGKRDLERGVVTIRDLESGNQV 414
+ LR++GI S++ +K++K YAN G ++G+ + + ++++++ SG Q+
Sbjct: 364 LAESLRQSGIFSEVYPEAQKIKKPFSYANHKGHEFVAVIGEEEFKSETLSLKNMHSGMQL 423
>emb|CAB93388.1| (AL357523) histidyl tRNA synthetase [Streptomyces coelicolor A3(2)]
Length = 425
Score = 221 bits (557), Expect = 1e-56
Identities = 148/449 (32%), Positives = 226/449 (49%), Gaps = 62/449 (13%)
Query: 6 KGTRDFLPEEMVKRRWVFEKIREVFETYGFKEVLTPVMEYTKLFQLRSGEE---VVKQLY 62
KGT D LP + K V E I G+ + TP E +LF GE V K++Y
Sbjct: 13 KGTYDLLPPDSAKFLAVREAIAAPLRNSGYGYIETPGFENVELFARGVGESTDIVTKEMY 72
Query: 63 AFKDKGGRDVALRPDMTSSVAR--LYVNSFQTAPKPIKWYYIANMFRYEEPQSGRYREFW 120
F+ KGG +ALRP+ T+ V R L N + P+K +Y + +RYE PQ GRYR F
Sbjct: 73 VFETKGGDRLALRPETTAPVLRAVLEANLHKAGNLPVKVWYSGSQYRYERPQKGRYRHFS 132
Query: 121 QAGVELIGSDKIEADAEVIALFVDSYLSTGLKDFTV---NIGD-------RVLLDEFAKM 170
Q G E IG++ DAE+I L SY + GL+DF + ++GD R L +F +
Sbjct: 133 QVGAEAIGAEDPALDAELIILADQSYRALGLQDFRILLNSLGDQECRPVYRAALQDFLRG 192
Query: 171 LGVKDD------IGLMRIIDKKDKLSQEEFLKALGEFGLDENGIEKVLNLIEIKGKPDDV 224
L + ++ I +R++D K Q++ +A
Sbjct: 193 LDLDEETLRRAEINPLRVLDDKRPDVQKQLTEA--------------------------- 225
Query: 225 LPLAEELFTS--ERAKEEISRLYNLVDILSWYEVDEWIQIDLGIARGFDYYTSIVFEAIV 282
PL + + EE+ L ++ + D + RG DYYT FE V
Sbjct: 226 -PLLRDYLCDACKAYHEEVRELITAAGVV--------FEDDPKLVRGLDYYTRTTFE-FV 275
Query: 283 PNDLGIGS-IGGGGRYDNLIEVFGGKPTPATGFAIGIERLIPILEWKGLLPELKAGPDVF 341
+ LG S +GGGGRYD L E+ GG P+ G+A+G++R + LE +G+ ++ + VF
Sbjct: 276 HDGLGSQSAVGGGGRYDGLSEMIGGPSLPSVGWALGVDRTVLALEAEGIELDIPSATSVF 335
Query: 342 VIPVG-DSRDVATAIVTRLRKAGIRSDIELSGRKLRKALDYANRIGVRLSIIVGKRDLER 400
+P+G ++R + A VT LRK G+ +D G+ L+ A+ ANR G R ++++G+RDL
Sbjct: 336 AVPLGEEARRILFAKVTELRKNGVAADFSYGGKGLKAAMKAANRSGARYTLVLGERDLAE 395
Query: 401 GVVTIRDLESGNQVEVPVDNVVTKVRELL 429
GVV ++D+ESG Q + V+ +V ++ L
Sbjct: 396 GVVQLKDMESGEQTAIGVNEIVAELESRL 424
>sp|Q9X0H5|SYH_THEMA HISTIDYL-TRNA SYNTHETASE (HISTIDINE--TRNA LIGASE) (HISRS)
>gi|7437817|pir||A72298 histidine--tRNA ligase (EC
6.1.1.21) - Thermotoga maritima (strain MSB8)
>gi|4981634|gb|AAD36166.1|AE001768_15 (AE001768)
histidyl-tRNA synthetase [Thermotoga maritima]
Length = 420
Score = 218 bits (550), Expect = 9e-56
Identities = 157/438 (35%), Positives = 236/438 (53%), Gaps = 33/438 (7%)
Query: 4 RVKGTRDFLPEEMVKRRWVFEKIREVFETYGFKEVLTPVMEYTKLFQLRSGEE---VVKQ 60
R+KGT D EE+ R+V E R V E+ G +E+ TP+ E T+LF GEE V K+
Sbjct: 5 RIKGTNDIFGEEIWYWRYVEETFRNVCESAGIEEIRTPIFEQTELFVRSVGEESDIVQKE 64
Query: 61 LYAFKDKGGRDVALRPDMTSSVARLYV-NSFQTAPKPIKWYYIANMFRYEEPQSGRYREF 119
+Y F+DK GR + LRP+ T+ V R ++ NS ++YYI MFRYE+PQSGR R+F
Sbjct: 65 MYTFQDKAGRSITLRPEGTAPVVRAFLENSLIDRGFQQRYYYIGPMFRYEKPQSGRLRQF 124
Query: 120 WQAGVELIGSDKIEADAEVIALFVDSYL-STGLKDFTV---NIGDRVLLDEFAKMLGVKD 175
Q G E+IG + +AD EVI L VD++L GL + + +IG V + + L K+
Sbjct: 125 HQVGFEIIGPESPKADFEVIML-VDTFLRRLGLTKYKIHLNSIGCPVCRKNYREAL--KE 181
Query: 176 DIGLMRIIDKKDKLSQEEFLKALGEFGLDENGIEKVLNLIEIKGKPDDVLPLAEELFTSE 235
G RI+D + + E I ++L+ K D L
Sbjct: 182 YYG--RILDNLCDDCKRRY----------ETNILRLLDC-----KVDHEYSLNAPKSVDY 224
Query: 236 RAKEEISRLYNLVDILSWYEVDEWIQIDLGIARGFDYYTSIVFEAIVPNDLGIGS-IGGG 294
+ L + L+ +E+ E+++ D + RG DYYT VFE + LG S I GG
Sbjct: 225 LCDSCRAHYKKLKEYLNTFEI-EYVE-DHTLVRGLDYYTRTVFE-VRHEGLGAQSAIAGG 281
Query: 295 GRYDNLIEVFGGKPTPATGFAIGIERLIPILEWKGLLPELKAGPDVFVIPVGDSRDV-AT 353
GRYD L GG PA GFA GIER+I L+ +G+ +K V++ +G+ +
Sbjct: 282 GRYDGLFAELGGSSVPALGFAGGIERIILALKAEGIEIPMKNVHLVYIATLGEKAFMDGV 341
Query: 354 AIVTRLRKAGIRSDIELSGRKLRKALDYANRIGVRLSIIVGKRDLERGVVTIRDLESGNQ 413
+ LRK G+ D+++ RKL L +A+R+G R ++I+G +LE+G+V +RDLE+G+Q
Sbjct: 342 RLAGELRKKGLSVDVDIMDRKLSGQLKHASRMGSRYAVIIGDEELEKGIVILRDLETGDQ 401
Query: 414 VEVPVDNVVTKVRELLNQ 431
VE+ D + E +++
Sbjct: 402 VEIDRDFAADYIAERVSK 419
>sp|O32422|SYH_STAAU HISTIDYL-TRNA SYNTHETASE (HISTIDINE--TRNA LIGASE) (HISRS)
>gi|2580436|dbj|BAA23141.1| (D76414) histidyl-tRNA
synthetase [Staphylococcus aureus]
Length = 420
Score = 217 bits (548), Expect = 2e-55
Identities = 144/444 (32%), Positives = 230/444 (51%), Gaps = 51/444 (11%)
Query: 1 MIERVKGTRDFLPEEMVKRRWVFEKIREVFETYGFKEVLTPVMEYTKLFQLRSGEE---V 57
MI+ +GT+D LPE+ K R++ ++ E+ Y +KE+ TP+ E T LF G+ V
Sbjct: 1 MIKIPRGTQDILPEDSKKWRYIENQLDELMTFYNYKEIRTPIFESTDLFARGVGDSTDVV 60
Query: 58 VKQLYAFKDKGGRDVALRPDMTSSVARLYV-NSFQTAP-KPIKWYYIANMFRYEEPQSGR 115
K++Y FKDKG R + LRP+ T++V R Y+ + Q P +PIK YY MFRYE Q GR
Sbjct: 61 QKEMYTFKDKGDRSITLRPEGTAAVVRSYIEHKMQGNPNQPIKLYYNGPMFRYERKQKGR 120
Query: 116 YREFWQAGVELIGSDKIEADAEVIALFVDSYLSTGLKDFTVNIGDRVLLDEFAKMLGVKD 175
YR+F Q GVE IG++ DAEV+A+ + Y S GLK + V +
Sbjct: 121 YRQFNQFGVEAIGAENPSVDAEVLAMVMHIYQSFGLKHLKL----------------VIN 164
Query: 176 DIGLMRIIDKKDKLSQEEFLKALGEFGLDENGIEKVLNLIEIKGKPDDVLPLAEELFTSE 235
+G M + ++ + F + EF D + P +L +
Sbjct: 165 SVGDMASRKEYNEALVKHFEPVIHEFCSDCQS--------RLHTNPMRILDC-----KVD 211
Query: 236 RAKEEISRLYNLVDIL-----SWYEVDEWIQIDLGI--------ARGFDYYTSIVFEAIV 282
R KE I + D L ++YE + DLGI RG DYYT FE ++
Sbjct: 212 RDKEAIKTAPRITDFLNEESKAYYEQVKAYLDDLGIPYIEDPNLVRGLDYYTHTAFELMM 271
Query: 283 PN---DLGIGSIGGGGRYDNLIEVFGGKPTPATGFAIGIERLIPILEWKGLLPELKAGPD 339
N D I ++ GGGRY+ L+E+ G GFA+ IERL+ LE +G+ +++ D
Sbjct: 272 DNPNYDGAITTLCGGGRYNGLLELLDGPSETGIGFALSIERLLLALEEEGIELDIEENLD 331
Query: 340 VFVIPVGDSRD-VATAIVTRLRKAGIRSDIELSGRKLRKALDYANRIGVRLSIIVGKRDL 398
+F++ +GD D A ++ LR GI++D + RK++ + A+R+G + +I++G ++L
Sbjct: 332 LFIVTMGDQADRYAVKLLNHLRHNGIKADKDYLQRKIKGQMKQADRLGAKFTIVIGDQEL 391
Query: 399 ERGVVTIRDLESGNQVEVPVDNVV 422
E + ++++ +G + +D +V
Sbjct: 392 ENNKIDVKNMTTGESETIELDALV 415
>pdb|1QE0|A Chain A, Crystal Structure Of Apo S. Aureus Histidyl-Trna
Synthetase >gi|9955268|pdb|1QE0|B Chain B, Crystal
Structure Of Apo S. Aureus Histidyl-Trna Synthetase
Length = 420
Score = 217 bits (547), Expect = 2e-55
Identities = 144/444 (32%), Positives = 230/444 (51%), Gaps = 51/444 (11%)
Query: 1 MIERVKGTRDFLPEEMVKRRWVFEKIREVFETYGFKEVLTPVMEYTKLFQLRSGEE---V 57
MI+ +GT+D LPE+ K R++ ++ E+ Y +KE+ TP+ E T LF G+ V
Sbjct: 1 MIKIPRGTQDILPEDSKKWRYIENQLDELMTFYNYKEIRTPIFESTDLFARGVGDSTDVV 60
Query: 58 VKQLYAFKDKGGRDVALRPDMTSSVARLYV-NSFQTAP-KPIKWYYIANMFRYEEPQSGR 115
K++Y FKDKG R + LRP+ T++V R Y+ + Q P +PIK YY MFRYE Q GR
Sbjct: 61 QKEMYTFKDKGDRSITLRPEGTAAVVRSYIEHKMQGNPNQPIKLYYNGPMFRYERKQKGR 120
Query: 116 YREFWQAGVELIGSDKIEADAEVIALFVDSYLSTGLKDFTVNIGDRVLLDEFAKMLGVKD 175
YR+F Q GVE IG++ DAEV+A+ + Y S GLK + V +
Sbjct: 121 YRQFNQFGVEAIGAENPSVDAEVLAMVMHIYQSFGLKHLKL----------------VIN 164
Query: 176 DIGLMRIIDKKDKLSQEEFLKALGEFGLDENGIEKVLNLIEIKGKPDDVLPLAEELFTSE 235
+G M + ++ + F + EF D + P +L +
Sbjct: 165 SVGDMASRKEYNEALVKHFEPVIHEFCSDCQS--------RLHTDPMRILDC-----KVD 211
Query: 236 RAKEEISRLYNLVDIL-----SWYEVDEWIQIDLGI--------ARGFDYYTSIVFEAIV 282
R KE I + D L ++YE + DLGI RG DYYT FE ++
Sbjct: 212 RDKEAIKTAPRITDFLNEESKAYYEQVKAYLDDLGIPYTEDPNLVRGLDYYTHTAFELMM 271
Query: 283 PN---DLGIGSIGGGGRYDNLIEVFGGKPTPATGFAIGIERLIPILEWKGLLPELKAGPD 339
N D I ++ GGGRY+ L+E+ G GFA+ IERL+ LE +G+ +++ D
Sbjct: 272 DNPNYDGAITTLCGGGRYNGLLELLDGPSETGIGFALSIERLLLALEEEGIELDIEENLD 331
Query: 340 VFVIPVGDSRD-VATAIVTRLRKAGIRSDIELSGRKLRKALDYANRIGVRLSIIVGKRDL 398
+F++ +GD D A ++ LR GI++D + RK++ + A+R+G + +I++G ++L
Sbjct: 332 LFIVTMGDQADRYAVKLLNHLRHNGIKADKDYLQRKIKGQMKQADRLGAKFTIVIGDQEL 391
Query: 399 ERGVVTIRDLESGNQVEVPVDNVV 422
E + ++++ +G + +D +V
Sbjct: 392 ENNKIDVKNMTTGESETIELDALV 415
>sp|O66522|SYH_AQUAE HISTIDYL-TRNA SYNTHETASE (HISTIDINE--TRNA LIGASE) (HISRS)
>gi|7428491|pir||G70311 histidine--tRNA ligase (EC
6.1.1.21) - Aquifex aeolicus >gi|2982856|gb|AAC06477.1|
(AE000674) histidyl-tRNA synthetase [Aquifex aeolicus]
Length = 403
Score = 215 bits (541), Expect = 1e-54
Identities = 147/429 (34%), Positives = 232/429 (53%), Gaps = 37/429 (8%)
Query: 2 IERVKGTRDFLPEEMVKRRWVFEKIREVFETYGFKEVLTPVMEYTKLFQLRSGEE---VV 58
I+ V+G D L ++ K R + + R++ + Y F+E++ PV+EY +LFQ GE V
Sbjct: 3 IQSVRGFHDILGKDAKKFRKISDTARKILKLYNFEEIILPVVEYAELFQRSVGETTDIVQ 62
Query: 59 KQLYAFKDKGGRDVALRPDMTSSVARLYVNSFQTAPKP-IKWYYIANMFRYEEPQSGRYR 117
K+++ F+D+ GR +ALRP+ T+ R ++ A +P +K +Y MFRYE PQ+GRYR
Sbjct: 63 KEMFVFEDRKGRKLALRPEGTAGTVRAFIQHKLYALRPYVKLFYEGPMFRYERPQAGRYR 122
Query: 118 EFWQAGVELIGSDKIEADAEVIALFVDSYLSTGLKDFTVNIGDRVLLDEFAKMLGVKDDI 177
+F Q G E+ G + ADAE+I + D + G+K V I LG K D
Sbjct: 123 QFHQIGAEVFGVAEPHADAEIIKIVYDILQALGIKGVVVEINS----------LGCKKDR 172
Query: 178 GLMR--IIDKKDKLSQEEFLKALGEFGLDENGIEKVLNLIEIKGKPDDVLPLAEELFTSE 235
R +++ + +E + +D N + + +E P + F +
Sbjct: 173 EAYREALLNYLTGVKEELCSDCISR--MDRNPLRVLDCKVETCKVAVREAPKMID-FLCD 229
Query: 236 RAKEEISRLYNLVDILSWYEVDEWIQIDLGIARGFDYYTSIVFEAIVPNDLGIGSIGGGG 295
+E +L N + L D + + + RG DYYT VFEA V ++LG+ I GG
Sbjct: 230 ECREHYEKLKNYLKAL-----DIPFRENYNLVRGLDYYTRTVFEA-VSDELGLTLI-AGG 282
Query: 296 RYDNLIEVFGGKPTPATGFAIGIERLIPILEWKGLLPELKAGPDV-FVIPVGDSRDVATA 354
RYD L+E GG PTPA GFA+G+ERL+ LLP+ + +V FVIP GD + A
Sbjct: 283 RYDYLVEELGGPPTPALGFALGVERLML------LLPDEEEKEEVYFVIPFGDVHEYALR 336
Query: 355 IVTRLRKAGIRSDIELSGRK--LRKALDYANRIGVRLSIIVGKRDLERGVVTIRDLESGN 412
+ LRK G +E S RK L+K L++A+++GV+ ++I+G+ +++ VTI+D+E+G
Sbjct: 337 VADILRKKG--KVVEYSYRKGGLKKQLEFADKLGVKYAVIIGEDEVKNQEVTIKDMETGE 394
Query: 413 QVEVPVDNV 421
Q V + +
Sbjct: 395 QRRVKLSEL 403
>dbj|BAB04970.1| (AP001511) histidyl-tRNA synthetase [Bacillus halodurans]
Length = 428
Score = 214 bits (540), Expect = 1e-54
Identities = 143/440 (32%), Positives = 244/440 (54%), Gaps = 36/440 (8%)
Query: 2 IERVKGTRDFLPEEMVKRRWVFEKIREVFETYGFKEVLTPVMEYTKLFQLRSGEE---VV 58
I+ +GT+D LP ++ +W+ +K ++ Y ++E+ P+ E+T+LF G+ V
Sbjct: 3 IQIPRGTQDILPGDVETWQWIEQKAYDLCRRYNYQEIRVPMFEHTELFLRGVGDTTDIVQ 62
Query: 59 KQLYAFKDKGGRDVALRPDMTSSVARLYVNS--FQTAPKPIKWYYIANMFRYEEPQSGRY 116
K++Y F+D+GGR + LRP+ T+SV R YV++ + A +P K +YI MFRYE PQSGR
Sbjct: 63 KEMYTFEDRGGRSLTLRPEGTASVTRAYVSNKLYGQANQPTKLFYIGPMFRYERPQSGRM 122
Query: 117 REFWQAGVELIGSDKIEADAEVIALFVDSYLSTGLKDFTVNIGDRVLLDEFAKMLGVKDD 176
R+F Q GVE +GS DAEV+AL + Y GLK+ + I LG D
Sbjct: 123 RQFVQFGVEALGSADPAIDAEVLALVMRFYEELGLKNLKLVINS----------LGDTDS 172
Query: 177 IGLMRIIDKKDKLSQEEFLKALGEFGLD-ENGIEK-VLNLIEIKGKPD-DVLPLAEEL-- 231
R+ ++ ++ F + EF D ++ +EK L +++ K D +++ A +
Sbjct: 173 ----RLAHREALVNH--FKPRIHEFCNDCQDRLEKNPLRILDCKKDRDHELMGTAPSIHD 226
Query: 232 FTSERAKEEISRLYNLVDILSWYEVDEWIQIDLGIARGFDYYTSIVFEAIVPNDLGIGSI 291
+ S +K ++ + + L+ V +D + RG DYY FE +V + G G+I
Sbjct: 227 YLSTESKAYFEKVQSYLTALNIPFV-----VDATLVRGLDYYNHTAFEVMVDGE-GFGAI 280
Query: 292 G---GGGRYDNLIEVFGGKPTPATGFAIGIERLIPILEWKGLLPELKAGPDVFVIPVGD- 347
GGGRY+ L+E GG TP GFA+ IER I LE + P D +V+ +G+
Sbjct: 281 TTLCGGGRYNGLVEEIGGPETPGIGFALSIERAIMALEAQQAKPAHNQAIDCYVVTLGEA 340
Query: 348 SRDVATAIVTRLRKAGIRSDIELSGRKLRKALDYANRIGVRLSIIVGKRDLERGVVTIRD 407
++D +V +LR AGI ++ + RK++ L A+R+ + ++I+G+ +L G V +++
Sbjct: 341 AKDKGVELVYQLRNAGISAEKDYLDRKMKGQLKAADRLHAKWTVILGEDELAVGKVNVKN 400
Query: 408 LESGNQVEVPVDNVVTKVRE 427
+E+G Q +V + ++V+ +++
Sbjct: 401 METGEQTDVALTDLVSHMKQ 420
>sp|O32039|SYH_BACSU HISTIDYL-TRNA SYNTHETASE (HISTIDINE--TRNA LIGASE) (HISRS)
>gi|7428490|pir||G69641 histidine--tRNA ligase (EC
6.1.1.21) hisS - Bacillus subtilis
>gi|2635220|emb|CAB14715.1| (Z99118) histidyl-tRNA
synthetase [Bacillus subtilis]
Length = 424
Score = 213 bits (538), Expect = 2e-54
Identities = 142/445 (31%), Positives = 234/445 (51%), Gaps = 64/445 (14%)
Query: 6 KGTRDFLPEEMVKRRWVFEKIREVFETYGFKEVLTPVMEYTKLFQLRSGEE---VVKQLY 62
+GT+D LP E + ++V + +R+ TY +KE+ TP+ E+T+LF GE V K++Y
Sbjct: 7 RGTQDILPGESDRWQFVEQIMRDTCRTYQYKEIRTPIFEHTELFARGVGESTDIVQKEMY 66
Query: 63 AFKDKGGRDVALRPDMTSSVARLYVNS--FQTAPKPIKWYYIANMFRYEEPQSGRYREFW 120
F+D+ GR + LRP+ T++ R + + F +P K YY+ MFRYE PQ+GRYR+F+
Sbjct: 67 TFEDRKGRSLTLRPEGTAAAVRAFNENKLFANPVQPTKLYYVGPMFRYERPQTGRYRQFY 126
Query: 121 QAGVELIGSDKIEADAEVIALFVDSYLSTGLKDFTV---NIGDR---------------V 162
Q G+E IGS DAEV+AL + Y GL++ + ++GD+
Sbjct: 127 QFGIEAIGSKDPAIDAEVMALAMSIYEKAGLENVKLVINSLGDQDSRKSYREALVKHFEP 186
Query: 163 LLDEFAKMLGVKDDIGLMRIID-KKDKLSQEEFLKALGEFGLDENGIEKVLNLIEIKGKP 221
++EF + +RI+D KKD+ E +K+ P
Sbjct: 187 RIEEFCSDCQSRLHTNPLRILDCKKDR--DHELMKS----------------------AP 222
Query: 222 DDVLPLAEELFTSERAKEEISRLYNLVDILSWYEVDEWIQIDLGIARGFDYYTSIVFEAI 281
+ L EE S E++ + N D+ YE+D + RG DYY FE I
Sbjct: 223 SILTYLNEE---SAAYFEKVKQYLN--DLGISYEIDP------NLVRGLDYYNHTAFE-I 270
Query: 282 VPNDLGIGSI---GGGGRYDNLIEVFGGKPTPATGFAIGIERLIPILEWKGLLPELKAGP 338
+ N G G+I GGGRYD L+E GG P GFA+ IERL+ ++ + + G
Sbjct: 271 MSNAEGFGAITTLAGGGRYDGLVEQIGGPEAPGIGFAMSIERLLAAIDAEKRELPVDKGI 330
Query: 339 DVFVIPVGD-SRDVATAIVTRLRKAGIRSDIELSGRKLRKALDYANRIGVRLSIIVGKRD 397
D +++ +G+ ++D + ++V +LR+AGI S+I+ +K++ A+R+ R I+G+ +
Sbjct: 331 DCYIVTLGEKAKDYSVSLVYKLREAGISSEIDYENKKMKGQFKTADRLKARFIAILGEDE 390
Query: 398 LERGVVTIRDLESGNQVEVPVDNVV 422
L + + ++D ++G Q+EV +D +
Sbjct: 391 LAQNKINVKDAQTGEQIEVALDEFI 415
>gi|6680167 histidyl tRNA synthetase [Mus musculus]
>gi|2501005|sp|Q61035|SYH_MOUSE HISTIDYL-TRNA SYNTHETASE
(HISTIDINE--TRNA LIGASE) (HISRS) >gi|2137380|pir||JC5223
histidine--tRNA ligase (EC 6.1.1.21) - mouse
>gi|1209683|gb|AAC52914.1| (U39473) histidyl-tRNA
synthetase [Mus musculus]
Length = 509
Score = 203 bits (512), Expect = 3e-51
Identities = 142/454 (31%), Positives = 238/454 (52%), Gaps = 27/454 (5%)
Query: 1 MIERVKGTRDFLPEEMVKRRWVFEKIREVFETYGFKEVLTPVMEYTKLFQLRSGEEVVKQ 60
+++ KGTRD+ P +M R VF+ I F+ +G + + TPV E + + GE+ K
Sbjct: 55 VLKTPKGTRDYSPRQMAVREKVFDVIIRCFKRHGAEVIDTPVFELKETLTGKYGEDS-KL 113
Query: 61 LYAFKDKGGRDVALRPDMTSSVARLYVNSFQTAPKPIKWYYIANMFRYEEPQS--GRYRE 118
+Y KD+GG ++LR D+T AR + T IK Y+IA ++R + P GRYRE
Sbjct: 114 IYDLKDQGGELLSLRYDLTVPFARYLAMNKLTN---IKRYHIAKVYRRDNPAMTRGRYRE 170
Query: 119 FWQAGVELIGS-DKIEADAEVIALFVDSYLSTGLKDFTVNIGDRVLLDEFAKMLGVKDDI 177
F+Q ++ G D + DAE + + + S + +F V + DR +LD + GV D
Sbjct: 171 FYQCDFDIAGQFDPMIPDAECLKIMCEILSSLQIGNFLVKVNDRRILDGMFAVCGVPDSK 230
Query: 178 --GLMRIIDKKDKLSQEEFLKAL-GEFGLDENGIEKVLNLIEIKGKPDDVLPLAEE--LF 232
+ +DK DK+S EE + GE GL +++ + ++ G V L ++ L
Sbjct: 231 FRTICSSVDKLDKVSWEEVKNEMVGEKGLAPEVADRIGDYVQQHGGVSLVEQLLQDPKLS 290
Query: 233 TSERAKEEISRLYNLVDILSWYEVDEWIQIDLGIARGFDYYTSIVFEAIV--------PN 284
+++A E + L L + L + +D+ I DL +ARG DYYT +++EA++
Sbjct: 291 QNKQAVEGLGDLKLLFEYLILFGIDDKISFDLSLARGLDYYTGVIYEAVLLQMPTQAGEE 350
Query: 285 DLGIGSIGGGGRYDNLIEVFG--GKPTPATGFAIGIERLIPILEWKGLLPELKAGPDVFV 342
LG+GSI GGRYD L+ +F G+ P G +IG+ER+ I+E + E K
Sbjct: 351 PLGVGSIAAGGRYDGLVGMFDPKGRKVPCVGLSIGVERIFSIVEQRLEASEEKVRTTETQ 410
Query: 343 IPVGDSR----DVATAIVTRLRKAGIRSD-IELSGRKLRKALDYANRIGVRLSIIVGKRD 397
+ V ++ + +V+ L AGI+++ + KL L Y G+ L I+G+++
Sbjct: 411 VLVASAQKKLLEERLKLVSELWDAGIKAELLYKKNPKLLNQLQYCEEAGIPLVAIIGEQE 470
Query: 398 LERGVVTIRDLESGNQVEVPVDNVVTKVRELLNQ 431
L+ GV+ +R + S +V+V +++V ++R NQ
Sbjct: 471 LKDGVIKLRSVASREEVDVQREDLVEEIRRRTNQ 504
>gi|6996014 histidyl tRNA synthetase; histidine tRNA ligase [Homo sapiens]
>gi|11416832|ref|XP_003823.1| histidyl tRNA synthetase
[Homo sapiens] >gi|135123|sp|P12081|SYH_HUMAN
HISTIDYL-TRNA SYNTHETASE (HISTIDINE--TRNA LIGASE)
(HISRS) >gi|2144560|pir||SYHUHT histidine--tRNA ligase
(EC 6.1.1.21) - human >gi|32460|emb|CAA77607.1| (Z11518)
histidyl-tRNA synthetase [Homo sapiens]
Length = 509
Score = 202 bits (509), Expect = 6e-51
Identities = 140/454 (30%), Positives = 239/454 (51%), Gaps = 27/454 (5%)
Query: 1 MIERVKGTRDFLPEEMVKRRWVFEKIREVFETYGFKEVLTPVMEYTKLFQLRSGEEVVKQ 60
+++ KGTRD+ P +M R VF+ I F+ +G + + TPV E + + GE+ K
Sbjct: 55 VLKTPKGTRDYSPRQMAVREKVFDVIIRCFKRHGAEVIDTPVFELKETLMGKYGEDS-KL 113
Query: 61 LYAFKDKGGRDVALRPDMTSSVARLYVNSFQTAPKPIKWYYIANMFRYEEPQS--GRYRE 118
+Y KD+GG ++LR D+T AR + T IK Y+IA ++R + P GRYRE
Sbjct: 114 IYDLKDQGGELLSLRYDLTVPFARYLAMNKLTN---IKRYHIAKVYRRDNPAMTRGRYRE 170
Query: 119 FWQAGVELIGS-DKIEADAEVIALFVDSYLSTGLKDFTVNIGDRVLLDEFAKMLGVKDDI 177
F+Q ++ G+ D + DAE + + + S + DF V + DR +LD + GV D
Sbjct: 171 FYQCDFDIAGNFDPMIPDAECLKIMCEILSSLQIGDFLVKVNDRRILDGMFAICGVSDSK 230
Query: 178 --GLMRIIDKKDKLSQEEFLKAL-GEFGLDENGIEKVLNLIEIKGKPDDVLPLAEE--LF 232
+ +DK DK+S EE + GE GL +++ + ++ G V L ++ L
Sbjct: 231 FRTICSSVDKLDKVSWEEVKNEMVGEKGLAPEVADRIGDYVQQHGGVSLVEQLLQDPKLS 290
Query: 233 TSERAKEEISRLYNLVDILSWYEVDEWIQIDLGIARGFDYYTSIVFEAIV--------PN 284
+++A E + L L + L+ + +D+ I DL +ARG DYYT +++EA++
Sbjct: 291 QNKQALEGLGDLKLLFEYLTLFGIDDKISFDLSLARGLDYYTGVIYEAVLLQTPAQAGEE 350
Query: 285 DLGIGSIGGGGRYDNLIEVFG--GKPTPATGFAIGIERLIPILEWKGLLPELKAGPDVFV 342
LG+GS+ GGRYD L+ +F G+ P G +IG+ER+ I+E + E K
Sbjct: 351 PLGVGSVAAGGRYDGLVGMFDPKGRKVPCVGLSIGVERIFSIVEQRLEALEEKIRTTETQ 410
Query: 343 IPVGDSR----DVATAIVTRLRKAGIRSD-IELSGRKLRKALDYANRIGVRLSIIVGKRD 397
+ V ++ + +V+ L AGI+++ + KL L Y G+ L I+G+++
Sbjct: 411 VLVASAQKKLLEERLKLVSELWDAGIKAELLYKKNPKLLNQLQYCEEAGIPLVAIIGEQE 470
Query: 398 LERGVVTIRDLESGNQVEVPVDNVVTKVRELLNQ 431
L+ GV+ +R + S +V+V +++V +++ Q
Sbjct: 471 LKDGVIKLRSVTSREEVDVRREDLVEEIKRRTGQ 504
>sp|P30053|SYH_STREQ HISTIDYL-TRNA SYNTHETASE (HISTIDINE--TRNA LIGASE) (HISRS)
>gi|11271795|pir||S30233 histidine--tRNA ligase (EC
6.1.1.21) [validated] - Streptococcus "equisimilis
Length = 426
Score = 202 bits (509), Expect = 6e-51
Identities = 134/432 (31%), Positives = 224/432 (51%), Gaps = 29/432 (6%)
Query: 2 IERVKGTRDFLPEEMVKRRWVFEKIREVFETYGFKEVLTPVMEYTKLFQLRSGEE---VV 58
+++ KGT+D L K ++V RE F+ Y + E+ TP+ E+ ++ G+ V
Sbjct: 3 LQKPKGTQDILSVAAAKWQYVEGVARETFKQYHYGEIRTPMFEHYEVISRSVGDTTDIVT 62
Query: 59 KQLYAFKDKGGRDVALRPDMTSSVARLYVNSFQTAP---KPIKWYYIANMFRYEEPQSGR 115
K++Y F DKG R + LRP+ T+ V R YV + AP KP+K YYI +MFRYE PQ+GR
Sbjct: 63 KEMYDFYDKGDRHITLRPEGTAPVVRSYVENKLFAPEVQKPVKLYYIGSMFRYERPQAGR 122
Query: 116 YREFWQAGVELIGSDKIEADAEVIALFVDSYLSTGLKDFTVNIGDRVLLDEFAKMLGVKD 175
REF Q GVE GS D E IA+ + G+K T+++ L A +
Sbjct: 123 LREFHQIGVECFGSANPATDVETIAMAYHLFERLGIKGVTLHLNS---LGNAASRAAYRQ 179
Query: 176 DIGLMRIIDKKDKLSQEEFLKALGEFGLDENGIEKVLNLIEIKGKPDDV-LPLAEEL--F 232
+ + + +D LS++ + LDEN L +++ K K D + + A + +
Sbjct: 180 AL-IDYLSPMRDTLSKDSQRR------LDENP----LRVLDSKEKEDKIAVANAPSILDY 228
Query: 233 TSERAKEEISRLYNLVDILSWYEVDEWIQIDLGIARGFDYYTSIVFEAIVPNDLGIGSIG 292
E ++ + ++++ L+ V ID + RG DYY +FE I D +I
Sbjct: 229 QDEESQAHFDAVRSMLEALAIPYV-----IDTNMVRGLDYYNHTIFEFITEVDQSELTIC 283
Query: 293 GGGRYDNLIEVFGGKPTPATGFAIGIERLIPILEWKGLLPELKAGPDVFVIPVG-DSRDV 351
GGRYD L+E FGG TP GF +G+ERL+ IL+ +G+ ++ G DV++ +G D+
Sbjct: 284 AGGRYDGLVEYFGGPATPGFGFGLGLERLLLILDKQGVELPVEEGLDVYIAVLGADANVA 343
Query: 352 ATAIVTRLRKAGIRSDIELSGRKLRKALDYANRIGVRLSIIVGKRDLERGVVTIRDLESG 411
A A+ +R+ G + + GRK++ A+ ++ I +G+ +++ G ++ ++
Sbjct: 344 ALALTQAIRRQGFTVERDYLGRKIKAQFKSADTFKAKVVITLGESEIKAGQAVLKHNQTR 403
Query: 412 NQVEVPVDNVVT 423
++ V D + T
Sbjct: 404 QEMTVSFDQIQT 415
>sp|Q50641|SYH_MYCTU HISTIDYL-TRNA SYNTHETASE (HISTIDINE--TRNA LIGASE) (HISRS)
>gi|7428488|pir||C70725 probable hisS protein -
Mycobacterium tuberculosis (strain H37RV)
>gi|1478232|emb|CAB01263.1| (Z77724) hisS [Mycobacterium
tuberculosis]
Length = 423
Score = 201 bits (506), Expect = 1e-50
Identities = 148/442 (33%), Positives = 213/442 (47%), Gaps = 57/442 (12%)
Query: 6 KGTRDFLPEEMVKRRWVFEKIREVFETYGFKEVLTPVMEYTKLFQLRSGEE---VVKQLY 62
KG D++P + + V + + G+ + P+ E T LF GE V K++Y
Sbjct: 11 KGVPDYVPPDSAQFVAVRDGLLAAARQAGYSHIELPIFEDTALFARGVGESTDVVSKEMY 70
Query: 63 AFKDKGGRDVALRPDMTSSVARLYV-NSFQTAPKPIKWYYIANMFRYEEPQSGRYREFWQ 121
F D+G R V LRP+ T+ V R + + P+K Y FRYE PQ+GRYR+ Q
Sbjct: 71 TFADRGDRSVTLRPEGTAGVVRAVIEHGLDRGALPVKLCYAGPFFRYERPQAGRYRQLQQ 130
Query: 122 AGVELIGSDKIEADAEVIALFVDSYLSTGLKDFTVNI---GD-------RVLLDEFAKML 171
GVE IG D DAEVIA+ + S GL F + I GD R LL EF L
Sbjct: 131 VGVEAIGVDDPALDAEVIAIADAGFRSLGLDGFRLEITSLGDESCRPQYRELLQEFLFGL 190
Query: 172 GVKDD------IGLMRIIDKKDKLSQEEFLKALGEFGLDENGIEKVLNLIEIKGKPDDVL 225
+ +D I +R++D DK + + A LD
Sbjct: 191 DLDEDTRRRAGINPLRVLD--DKRPELRAMTASAPVLLDH-------------------- 228
Query: 226 PLAEELFTSERAKEEISRLYNLVDILSWYEVDEWIQIDLGIARGFDYYTSIVFEAIVPND 285
S+ AK+ + +D L V I+ + RG DYYT FE V +
Sbjct: 229 -------LSDVAKQHFDTVLAHLDALGVPYV-----INPRMVRGLDYYTKTAFE-FVHDG 275
Query: 286 LGIGS-IGGGGRYDNLIEVFGGKPTPATGFAIGIERLIPILEWKGLLPELKAGPDVFVIP 344
LG S IGGGGRYD L+ GG+ GF +G++R + L +G A DVF +P
Sbjct: 276 LGAQSGIGGGGRYDGLMHQLGGQDLSGIGFGLGVDRTVLALRAEGKTAGDSARCDVFGVP 335
Query: 345 VGDSRDVATAIVT-RLRKAGIRSDIELSGRKLRKALDYANRIGVRLSIIVGKRDLERGVV 403
+G++ + A++ RLR AG+R D+ R L+ A+ A R G R++++ G RD+E G V
Sbjct: 336 LGEAAKLRLAVLAGRLRAAGVRVDLAYGDRGLKGAMRAAARSGARVALVAGDRDIEAGTV 395
Query: 404 TIRDLESGNQVEVPVDNVVTKV 425
++DL +G QV V +D+VV +V
Sbjct: 396 AVKDLTTGEQVSVSMDSVVAEV 417
>gb|AAD10241.1| (AF020716) histidyl-tRNA synthetase [Triticum aestivum]
Length = 479
Score = 199 bits (501), Expect = 5e-50
Identities = 139/436 (31%), Positives = 226/436 (50%), Gaps = 16/436 (3%)
Query: 6 KGTRDFLPEEMVKRRWVFEKIREVFETYGFKEVLTPVMEYTKLFQLRSGEEVVKQLYAFK 65
KGTRDF E+M R F I VF+ +G + TPV E + + GE+ K +Y
Sbjct: 47 KGTRDFGREQMAIRERAFSIITSVFKMHGGVALDTPVFELRETLMGKYGEDS-KLVYDLA 105
Query: 66 DKGGRDVALRPDMTSSVARLYVNSFQTAPKPIKWYYIANMFRYEEPQSGRYREFWQAGVE 125
D+GG +LR D+T AR + +A IK Y IA ++R + P GRYREF+Q +
Sbjct: 106 DQGGELCSLRYDLTVPFARYVAMNNISA---IKRYQIAKVYRRDNPSKGRYREFYQCDFD 162
Query: 126 LIGS-DKIEADAEVIALFVDSYLSTGLKDFTVNIGDRVLLDEFAKMLGVKDDI--GLMRI 182
+ G + +E D EV+ + + + D+ + + R LLD ++ GV + +
Sbjct: 163 IAGVYEPMEPDFEVVKVLTELLDKLDIGDYEIKLNHRKLLDGMLEICGVPAEKFRTVCSS 222
Query: 183 IDKKDKLSQEEFLKAL-GEFGLDENGIEKVLNLIEIKGKPDDVL----PLAEELFTSERA 237
IDK DKL+ EE K L E G+ E + +L++ +G P +VL + +E +
Sbjct: 223 IDKLDKLTFEEVKKELVEEKGVSNETAENIGSLVKTRGPPLEVLLELRKEGSKFMENEGS 282
Query: 238 KEEISRLYNLVDILSWYEVDEWIQIDLGIARGFDYYTSIVFEAIVPNDLGIGSIGGGGRY 297
++ L L L + I DL +ARG DYYT +++EA+ +GSI GGRY
Sbjct: 283 VVALNELEILFKALEKANALDRISFDLSLARGLDYYTGVIYEAVFKGVTQVGSIAAGGRY 342
Query: 298 DNLIEVFGGKPTPATGFAIGIERLIPILEW--KGLLPELKA-GPDVFVIPVGDSRDVATA 354
D L+ +F K PA G + GIER+ I+E K ++A +V V +G +A
Sbjct: 343 DKLVGMFSNKQVPAVGVSFGIERVFAIMEQQEKEKNQVIRATETEVLVSILGKDLILAAE 402
Query: 355 IVTRLRKAGIRSDIELSGRKLRKALDYANRIGVRLSIIVGKRDLERGVVTIRDLESGNQV 414
+V L AGI+++ +L+ R ++ + YA + G+ ++VG+ +L G V ++D+ + +
Sbjct: 403 LVNELWSAGIKAEFKLTTR-VQNHIKYATQTGIPWMVLVGESELRDGKVKLKDIRANQEE 461
Query: 415 EVPVDNVVTKVRELLN 430
EVP + V +++ L+
Sbjct: 462 EVPRKDFVEVLKQRLS 477
>gb|AAD10242.1| (AF020717) histidyl-tRNA synthetase [Triticum aestivum]
Length = 432
Score = 196 bits (492), Expect = 6e-49
Identities = 138/435 (31%), Positives = 225/435 (51%), Gaps = 16/435 (3%)
Query: 7 GTRDFLPEEMVKRRWVFEKIREVFETYGFKEVLTPVMEYTKLFQLRSGEEVVKQLYAFKD 66
GTRDF E+M R F I VF+ +G + TPV E + + GE+ K +Y D
Sbjct: 1 GTRDFGREQMAIRERAFSIITSVFKMHGGVALDTPVFELRETLMGKYGEDS-KLVYDLAD 59
Query: 67 KGGRDVALRPDMTSSVARLYVNSFQTAPKPIKWYYIANMFRYEEPQSGRYREFWQAGVEL 126
+GG +LR D+T AR + +A IK Y IA ++R + P GRYREF+Q ++
Sbjct: 60 QGGELCSLRYDLTVPFARYVAMNNISA---IKRYQIAKVYRRDNPSKGRYREFYQCDFDI 116
Query: 127 IGS-DKIEADAEVIALFVDSYLSTGLKDFTVNIGDRVLLDEFAKMLGVKDDI--GLMRII 183
G + +E D EV+ + + + + + + R LLD ++ GV + + I
Sbjct: 117 AGVYEPMEPDFEVVKVLTELLDKLDIGVYEIKLNHRKLLDGMLEICGVPAEKFRTVCSSI 176
Query: 184 DKKDKLSQEEFLKAL-GEFGLDENGIEKVLNLIEIKGKPDDVL----PLAEELFTSERAK 238
DK DKL+ EE K L E G+ E + +L++ KG P +VL + +E +
Sbjct: 177 DKLDKLTFEEVKKELVEEKGVSNETAENIGSLVKTKGPPLEVLLELRKEGSKFMENEGSV 236
Query: 239 EEISRLYNLVDILSWYEVDEWIQIDLGIARGFDYYTSIVFEAIVPNDLGIGSIGGGGRYD 298
++ L L L + I DL +ARG DYYT +++EA+ +GSI GGRYD
Sbjct: 237 VALNELEILFKALEKANALDRISFDLSLARGLDYYTGVIYEAVFKGVTQVGSIAAGGRYD 296
Query: 299 NLIEVFGGKPTPATGFAIGIERLIPILEW--KGLLPELKA-GPDVFVIPVGDSRDVATAI 355
L+ +F K PA G ++GIER+ I+E K ++A +V V +G +A +
Sbjct: 297 KLVGMFSNKQVPAVGVSLGIERVFAIMEQQEKEKNQVIRATETEVLVSILGKDLILAAEL 356
Query: 356 VTRLRKAGIRSDIELSGRKLRKALDYANRIGVRLSIIVGKRDLERGVVTIRDLESGNQVE 415
V L AGI+++ +L+ R ++ + YA + G+ ++VG+ +L G V ++D+ + + E
Sbjct: 357 VNELWSAGIKAEFKLTTR-VQNHIKYATQTGIPWMVLVGESELRDGKVKLKDIRANQEEE 415
Query: 416 VPVDNVVTKVRELLN 430
VP + V +++ L+
Sbjct: 416 VPRKDFVEVLKQRLS 430
>sp|P93422|SYH_ORYSA HISTIDYL-TRNA SYNTHETASE (HISTIDINE--TRNA LIGASE) (HISRS)
>gi|7437810|pir||T03774 probable histidine--tRNA ligase
(EC 6.1.1.21) - rice >gi|1841704|emb|CAB06653.1|
(Z85984) histidyl tRNA Synthetase [Oryza sativa]
Length = 494
Score = 194 bits (489), Expect = 1e-48
Identities = 133/422 (31%), Positives = 223/422 (52%), Gaps = 17/422 (4%)
Query: 6 KGTRDFLPEEMVKRRWVFEKIREVFETYGFKEVLTPVMEYTKLFQLRSGEEVVKQLYAFK 65
KGTRDF E+M R F I VF+ +G + TPV E + + GE+ K +Y
Sbjct: 63 KGTRDFGKEQMAIREHAFSIITGVFKMHGAVSLDTPVFELRETLMGKYGEDS-KLIYDLA 121
Query: 66 DKGGRDVALRPDMTSSVAR-LYVNSFQTAPKPIKWYYIANMFRYEEPQSGRYREFWQAGV 124
D+GG +LR D+T AR + +N+ + +K Y IA ++R + P GRYREF+Q
Sbjct: 122 DQGGELCSLRYDLTVPFARYVAMNNISS----LKRYQIAKVYRRDNPSKGRYREFYQCDF 177
Query: 125 ELIGS-DKIEADAEVIALFVDSYLSTGLKDFTVNIGDRVLLDEFAKMLGVKDDI--GLMR 181
++ G + +E D EVI + + + + + + R LLD ++ GV + +
Sbjct: 178 DIAGVYETMEPDFEVIKVLTELLDQLDIGTYEIKLNHRKLLDGMLEICGVPPEKFRTVCS 237
Query: 182 IIDKKDKLSQEEFLKAL-GEFGLDENGIEKVLNLIEIKGKPDDVL----PLAEELFTSER 236
IDK DK + E+ K L E G+ +K+ +L++ +G P +VL + +
Sbjct: 238 SIDKLDKQTFEQVKKELVDEKGISNETADKIGDLVKTRGPPLEVLLELRKEGSKFMGNAG 297
Query: 237 AKEEISRLYNLVDILSWYEVDEWIQIDLGIARGFDYYTSIVFEAIVPNDLGIGSIGGGGR 296
+ ++ L L L I DL +ARG DYYT +++EA+ +GSI GGR
Sbjct: 298 SVTALNELEILFKALDKANAIGKIVFDLSLARGLDYYTGVIYEAVFKGTTQVGSIAAGGR 357
Query: 297 YDNLIEVFGGKPTPATGFAIGIERLIPILEWKGL-LPELKA-GPDVFVIPVGDSRDVATA 354
YDNL+ +F GK PA G ++GIER+ I+E + + +++A +V V +G +A
Sbjct: 358 YDNLVGMFSGKQVPAVGVSLGIERVFAIMEQQEMEKNQIRATETEVLVSIIGKDLILAAE 417
Query: 355 IVTRLRKAGIRSDIELSGRKLRKALDYANRIGVRLSIIVGKRDLERGVVTIRDLESGNQV 414
+V+ L AGI+++ +L+ R ++ L YA + G+ ++VG+ ++ G V +++L + +
Sbjct: 418 LVSELWNAGIKAEFKLTTR-IQNHLKYATQSGIPWMVLVGESEISSGKVKLKNLAASQEE 476
Query: 415 EV 416
EV
Sbjct: 477 EV 478
>sp|O83647|SYH_TREPA HISTIDYL-TRNA SYNTHETASE (HISTIDINE--TRNA LIGASE) (HISRS)
>gi|7437806|pir||H71298 histidine--tRNA ligase (EC
6.1.1.21) (hisS) - syphilis spirochete
>gi|3322940|gb|AAC65615.1| (AE001239) histidyl-tRNA
synthetase (hisS) [Treponema pallidum]
Length = 442
Score = 194 bits (489), Expect = 1e-48
Identities = 126/425 (29%), Positives = 207/425 (48%), Gaps = 10/425 (2%)
Query: 5 VKGTRDFLPEEMVKRRWVFEKIREVFETYGFKEVLTPVMEYTKLFQLRSGEEVVKQLYAF 64
+KG RD LP+E ++R + EK+ GF + TP +EYT++ +S + KQ++ F
Sbjct: 12 LKGFRDLLPDEEIERALLVEKLTVALRQMGFVPIDTPALEYTEVLLRKSEGDTEKQMFRF 71
Query: 65 KDKGGRDVALRPDMTSSVARLYVNSFQTAPKPIKWYYIANMFRYEEPQSGRYREFWQAGV 124
DKGGRDVALR D+T +AR + P K Y+ A ++R E+PQ GRYREF Q
Sbjct: 72 VDKGGRDVALRFDLTVPLARFVATHYARLYFPFKRYHFAKVWRGEKPQMGRYREFTQCDF 131
Query: 125 ELIGSDKIEADAEVIALFVDSYLSTGLKDFTVNIGDRVLLDEFAKMLGVKDDI-GLMRII 183
+++GSD + AD E++ G + +++ R L D F + L + D ++RII
Sbjct: 132 DIVGSDSVCADFEILKSIRHMLYMAGAEHIRIHVAHRGLFDRFLRALSLSDQAEHILRII 191
Query: 184 DKKDKLSQEEFLKALGEFGLDENGIEKVLNLIEIKGKPDDVLPLAEELFTSER-----AK 238
DK+ K++ L A E D ++K++ + G+ D V P E ++
Sbjct: 192 DKRAKMA-PHVLTAQLESLCDPVRVQKIMTYVS-AGEVDGVAPSFEHTLSAIETLTGGVS 249
Query: 239 EEISRLYNLVDILSWYEVDEWIQIDLGIARGFDYYTSIVFEAIVPNDLGIGSIGGGGRYD 298
EE +RL + ++L + D I RGFDYYT +V E + IGS+ GGRYD
Sbjct: 250 EESTRLRKIYELLCAVNIQSSYVFDPSITRGFDYYTGMVCETFLTQLPHIGSVCSGGRYD 309
Query: 299 NLIEVFGGKPTPATGFAIGIERLIPILEWKGLLPELKAGPDVFVIPVGDSRDVATAIVTR 358
+L ++ G +IG++RL + G+ E + + +
Sbjct: 310 HLTALYMKDAVSGVGASIGLDRLYAAFQQLGMSREHVCFVQALIFCQDSALMDVYQKLCS 369
Query: 359 LRKAGIRSDIELSGRKLRKALDYANRIGVRLSIIVGKRD--LERGVVTIRDLESGNQVEV 416
+ +++ RKL + +A + G+R I V +R+ +E ++ +RDL + +
Sbjct: 370 YFAVQVATEVFPDPRKLSQQYAFAEKKGIRWGIFVEQRNAVVEDCLLVLRDLSTRKDTRL 429
Query: 417 PVDNV 421
P V
Sbjct: 430 PAHEV 434
>gb|AAF26984.1|AC018363_29 (AC018363) putative histidyl tRNA synthetase [Arabidopsis thaliana]
Length = 479
Score = 194 bits (487), Expect = 2e-48
Identities = 136/420 (32%), Positives = 216/420 (51%), Gaps = 18/420 (4%)
Query: 6 KGTRDFLPEEMVKRRWVFEKIREVFETYGFKEVLTPVMEYTKLFQLRSGEEVVKQLYAFK 65
KGTRDF E+M R F I+ VF+ +G + TPV E + + GE+ K +Y
Sbjct: 46 KGTRDFAKEQMAVREKAFSIIQNVFKRHGATALDTPVFELRETLMGKYGEDS-KLVYDIA 104
Query: 66 DKGGRDVALRPDMTSSVARLYVNSFQTAPKPIKWYYIANMFRYEEPQSGRYREFWQAGVE 125
D+GG +LR D+T AR + T+ K Y IA ++R + P GRYREF+Q +
Sbjct: 105 DQGGELCSLRYDLTVPFARYVAMNGITS---FKRYQIAKVYRRDNPSKGRYREFYQCDFD 161
Query: 126 LIGS-DKIEADAEVIALFVDSYLSTGLKDFTVNIGDRVLLDEFAKMLGVKDDI--GLMRI 182
+ G + + D E++ + + + D+ V + R LLD ++ GV + +
Sbjct: 162 IAGLFEPMGPDFEIVKILTELLDELEIGDYEVKLNHRKLLDGMLEICGVPPEKFRTICSS 221
Query: 183 IDKKDKLSQEEFLKAL-GEFGLDENGIEKVLNLIEIKGKPDDVLPL----AEELFTSERA 237
IDK DK S E+ K + E GL +++ N ++ KG P ++L E ++ +
Sbjct: 222 IDKLDKQSFEQVKKEMVEEKGLSSEIADRIGNFVKEKGAPLELLSKLRQEGSEFLDNQSS 281
Query: 238 KEEISRLYNLVDILSWYEVDEWIQIDLGIARGFDYYTSIVFEAIVPNDLGIGSIGGGGRY 297
+E + L + + L + E I DL +ARG DYYT ++FEA+ +GSIG GGRY
Sbjct: 282 REALDELSIMFEALKRSKCSERIVFDLSLARGLDYYTGVIFEAVCIG-AEVGSIGAGGRY 340
Query: 298 DNLIEVFGGKPTPATGFAIGIERLIPILEWKGLLPELKAGPD----VFVIPVGDSRDVAT 353
DNLI +FG K PA G ++GIER+ I+E + P + I V + A
Sbjct: 341 DNLIGMFGTKQVPAVGMSLGIERVFNIMEELNEKQKQVIRPTETQVLVSIMVDNKLAEAA 400
Query: 354 AIVTRLRKAGIRSDIELSGRKLRKALDYANRIGVRLSIIVGKRDLERGVVTIRDLESGNQ 413
+V++L A I ++ +S RK K + A G+ ++VG+++L VT++ LE G++
Sbjct: 401 ELVSQLWGAKINAEYLVSKRK-EKHFNRAKESGIPWMVMVGEKELSGSFVTLKKLEKGSE 459
>pir||S30232 histidine--tRNA ligase (EC 6.1.1.21) - Streptococcus "equisimilis"
(fragment) >gi|1333826|emb|CAA78919.1| (Z17214)
histidine--tRNA ligase [Streptococcus equisimilis]
Length = 407
Score = 192 bits (482), Expect = 8e-48
Identities = 127/407 (31%), Positives = 211/407 (51%), Gaps = 29/407 (7%)
Query: 27 REVFETYGFKEVLTPVMEYTKLFQLRSGEE---VVKQLYAFKDKGGRDVALRPDMTSSVA 83
RE F+ Y + E+ TP+ E+ ++ G+ V K++Y F DKG R + LRP+ T+ V
Sbjct: 9 RETFKQYHYGEIRTPMFEHYEVISRSVGDTTDIVTKEMYDFYDKGDRHITLRPEGTAPVV 68
Query: 84 RLYVNSFQTAP---KPIKWYYIANMFRYEEPQSGRYREFWQAGVELIGSDKIEADAEVIA 140
R YV + AP KP+K YYI +MFRYE PQ+GR REF Q GVE GS D E IA
Sbjct: 69 RSYVENKLFAPEVQKPVKLYYIGSMFRYERPQAGRLREFHQIGVECFGSANPATDVETIA 128
Query: 141 LFVDSYLSTGLKDFTVNIGDRVLLDEFAKMLGVKDDIGLMRIIDKKDKLSQEEFLKALGE 200
+ + G+K T+++ L A + + + + +D LS++ +
Sbjct: 129 MAYHLFERLGIKGVTLHLNS---LGNAASRAAYRQAL-IDYLSPMRDTLSKDSQRR---- 180
Query: 201 FGLDENGIEKVLNLIEIKGKPDDV-LPLAEEL--FTSERAKEEISRLYNLVDILSWYEVD 257
LDEN L +++ K K D + + A + + E ++ + ++++ L+ V
Sbjct: 181 --LDENP----LRVLDSKEKEDKIAVANAPSILDYQDEESQAHFDAVRSMLEALAIPYV- 233
Query: 258 EWIQIDLGIARGFDYYTSIVFEAIVPNDLGIGSIGGGGRYDNLIEVFGGKPTPATGFAIG 317
ID + RG DYY +FE I D +I GGRYD L+E FGG TP GF +G
Sbjct: 234 ----IDTNMVRGLDYYNHTIFEFITEVDQSELTICAGGRYDGLVEYFGGPATPGFGFGLG 289
Query: 318 IERLIPILEWKGLLPELKAGPDVFVIPVG-DSRDVATAIVTRLRKAGIRSDIELSGRKLR 376
+ERL+ IL+ +G+ ++ G DV++ +G D+ A A+ +R+ G + + GRK++
Sbjct: 290 LERLLLILDKQGVELPVEEGLDVYIAVLGADANVAALALTQAIRRQGFTVERDYLGRKIK 349
Query: 377 KALDYANRIGVRLSIIVGKRDLERGVVTIRDLESGNQVEVPVDNVVT 423
A+ ++ I +G+ +++ G ++ ++ ++ V D + T
Sbjct: 350 AQFKSADTFKAKVVITLGESEIKAGQAVLKHNQTRQEMTVSFDQIQT 396
>sp|P70076|SYH_FUGRU HISTIDYL-TRNA SYNTHETASE (HISTIDINE--TRNA LIGASE) (HISRS)
>gi|1524039|emb|CAA91012.1| (Z54243) histidyl-tRNA
synthetase [Takifugu rubripes]
Length = 519
Score = 191 bits (480), Expect = 1e-47
Identities = 138/465 (29%), Positives = 237/465 (50%), Gaps = 47/465 (10%)
Query: 1 MIERVKGTRDFLPEEMVKRRWVFEKIREVFETYGFKEVLTPVMEYTKLFQLRSGEEVVKQ 60
+++ KGTRD+ P++M R VF I F+ +G + + TPV E + + GE+ K
Sbjct: 60 VLKTAKGTRDYNPKQMAIREKVFNTIVSCFKRHGAETIDTPVFELKETLTGKYGED-SKL 118
Query: 61 LYAFKDKGGRDVALRPDMTSSVAR-LYVNSFQTAPKPIKWYYIANMFRYEEP--QSGRYR 117
+Y KD+GG ++LR D+T AR L +N IK Y+IA ++R + P GRYR
Sbjct: 119 IYDLKDQGGELLSLRYDLTVPFARYLAMNKITN----IKRYHIAKVYRRDNPAMTRGRYR 174
Query: 118 EFWQAGVELIGS-DKIEADAEVIALFVDSYLSTGLKDFTVNIGDRVLLDEFAKMLGVKDD 176
EF+Q ++ G D + DAE + + + L DF + + DR +LD + GV D+
Sbjct: 175 EFYQCDFDIAGQYDAMIPDAECLKIVHEILSELDLGDFRIKVNDRRILDGMFAVCGVPDN 234
Query: 177 I--GLMRIIDKKDKLSQEEFL-KALGEFGLDENGIEKVLNLIEIKGKPDDVLPLAEELFT 233
+ + +DK DKL E + + E GL E +++ + ++G D LAE L
Sbjct: 235 MFRTICSTVDKLDKLPWEAVKNEMVNEKGLSEEAADQIGVYVGMQGGMD----LAERLLQ 290
Query: 234 SERAKEEISRLYNLVDI------LSWYEVDEWIQIDLGIARGFDYYTSIVFEAIV----- 282
++ + L DI L ++V + + DL +ARG DYYT I++EAI+
Sbjct: 291 DQKMCQSTQACAGLTDIKLLFSYLQLFQVTDKVVFDLSLARGLDYYTGIIYEAILTQAGV 350
Query: 283 -----------PND--LGIGSIGGGGRYDNLIEVFG--GKPTPATGFAIGIERLIPILEW 327
P + + +GS+ GGGRYD L+ +F G+ P G +IGIER+ I+E
Sbjct: 351 APVAPETSNEAPTEECVTVGSVAGGGRYDGLVGMFDPKGRKVPCVGVSIGIERIFSIMEQ 410
Query: 328 KGLLPELKAGPDVFVIPVGDSR----DVATAIVTRLRKAGIRSDIEL-SGRKLRKALDYA 382
K K + V ++ + ++T L AGI++++ KL L +
Sbjct: 411 KAEASTEKIRTTEVQVMVAAAQKNLLEERLRLITELWNAGIKAELMYKKSPKLLSQLQHC 470
Query: 383 NRIGVRLSIIVGKRDLERGVVTIRDLESGNQVEVPVDNVVTKVRE 427
G+ L I+G+++L+ GVV +R++ + ++V++ +++ ++++
Sbjct: 471 EESGIPLVAILGEQELKNGVVKLRNVATRDEVDISRADLIAEIKK 515
>pir||A82586 histidyl-tRNA synthetase XF2222 [imported] - Xylella fastidiosa
(strain 9a5c) >gi|9107369|gb|AAF85021.1|AE004034_11
(AE004034) histidyl-tRNA synthetase [Xylella fastidiosa]
Length = 466
Score = 189 bits (475), Expect = 5e-47
Identities = 135/459 (29%), Positives = 222/459 (47%), Gaps = 39/459 (8%)
Query: 7 GTRDFLPEEMVKRRWVFEKIREVFETYGFKEVLTPVMEYTKLFQLRSGEEVVKQLYAFKD 66
G + LP E + + + + IR +E +GF V TPV E + + +SG E +Q+Y +
Sbjct: 9 GVLELLPREQIAFQRMLDVIRRNYERFGFLPVETPVFELSDVLLTKSGGETERQVYFVQS 68
Query: 67 KGGR------------DVALRPDMTSSVARLYVNSFQTAPKPIKWYYIANMFRYEEPQSG 114
G ++ALR D+T +AR P + Y + ++R E Q G
Sbjct: 69 TGTLANAAESGATRLPELALRFDLTVPLARYVAEYEHVLAFPFRRYQMQRVYRGERAQRG 128
Query: 115 RYREFWQAGVELIGSD--KIEADAEVIALFVDSYLSTGLKDFTVNIGDRVLLDEFAKMLG 172
R+REF+Q +++IG I DAEV+A+ + G+ DF V + +R +L F + G
Sbjct: 129 RFREFYQCDIDVIGKQTLSIRYDAEVLAVIHAVFSELGIGDFQVQLNNRKVLRGFLESQG 188
Query: 173 VKD---DIGLMRIIDKKDK---LSQEEFLKALGEFGLDENGIEKVLN------------L 214
V+D + ++R +DK DK L + L G FG+ +E +L L
Sbjct: 189 VRDGDLQLAVLREVDKLDKRGVLDVRDTLIGQG-FGIPAAQVENILTFVATRSTSHADAL 247
Query: 215 IEIKGKPDDVLPLAEELFTSERAKEEISRLYNLVDILSWYEVDEWIQIDLGIARGFDYYT 274
+ + +D P A E+ A E+ + LV++L E +++ IARG DYYT
Sbjct: 248 VRLDALIEDSGPEAHEMLRQGVA--ELREVLTLVNVLGVPE--HAYRLNFSIARGLDYYT 303
Query: 275 SIVFEAIVPNDLGIGSIGGGGRYDNLIEVFGGKPTPATGFAIGIERLIPILEWKGLLPEL 334
V+E + N IGSI GGRY+NL + P G +IG+ RL L G++ +
Sbjct: 304 GTVYETSLINHPQIGSICSGGRYENLANHYTQSKLPGVGISIGLTRLFWQLRDAGVMDGI 363
Query: 335 KAGPDVFVIPVGD--SRDVATAIVTRLRKAGIRSDIELSGRKLRKALDYANRIGVRLSII 392
++ + D + D A I LR GI +++++ +K+ K YA+R G+R ++
Sbjct: 364 AESSVQAMVVLMDEATLDDALDIARCLRIGGINTEVQMEAKKVSKQFQYASRAGIRFVVL 423
Query: 393 VGKRDLERGVVTIRDLESGNQVEVPVDNVVTKVRELLNQ 431
G + RGVV ++DL Q E+P + + + ++ L Q
Sbjct: 424 AGDDERARGVVAVKDLTREQQFEIPREELASTLQVELEQ 462
>sp|O51160|SYH_BORBU HISTIDYL-TRNA SYNTHETASE (HISTIDINE--TRNA LIGASE) (HISRS)
>gi|7428494|pir||G70116 histidine--tRNA ligase (EC
6.1.1.21) hisS - Lyme disease spirochete
>gi|2688030|gb|AAC66531.1| (AE001125) histidyl-tRNA
synthetase (hisS) [Borrelia burgdorferi]
Length = 457
Score = 189 bits (474), Expect = 7e-47
Identities = 121/449 (26%), Positives = 229/449 (50%), Gaps = 29/449 (6%)
Query: 2 IERVKGTRDFLPEEMVKRRWVFEKIREVFETYGFKEVLTPVMEYTKLFQLRSGEEVVKQL 61
I+ +KG +D+LP++ + R + +I V +Y F + TPV+EY+ L +SG+E KQ+
Sbjct: 4 IKTLKGFKDYLPKDSLIRIHIVRQIFSVLNSYNFDLIDTPVLEYSDLLLKKSGDETEKQI 63
Query: 62 YAFKDKGGRDVALRPDMTSSVARLYVNSFQTAPKPIKWYYIANMFRYEEPQSGRYREFWQ 121
Y FKD GGRDV++R D+T AR + P + +FR E Q GRYREF Q
Sbjct: 64 YRFKDNGGRDVSMRFDLTVPFARFVATNISALKLPFRRSQFGKVFRGENSQKGRYREFMQ 123
Query: 122 AGVELIGSDKIEADAEVIAL-------FVDSYLSTGLKDFTVNIGDRVLLDEFAKMLGVK 174
+++G D DAE++++ +++ K F ++ +L+ F + LG+K
Sbjct: 124 FDFDIVGEDTFRGDAEILSVVYYGLEEIFLNFIEGINKKFIIHYSHIGILNSFFEKLGLK 183
Query: 175 D-DIGLMRIIDKKDKLSQEEFLKALGEFGLDENGIEKVLNLIEIKGKPDDVLPLAEELFT 233
+ I ++R IDK DK+ ++ +AL +++ ++ +L+L+ ++G D + + +
Sbjct: 184 EKSIFILRNIDKIDKIGIDKVKEAL-LLEIEKEAVDSILSLVSLQGTFKDKIQALKSILG 242
Query: 234 SERAKEEISRLYNLVDILSWYEVDEWIQIDLGIARGFDYYTSIVFEAIVPNDLGIGSIGG 293
E I R+ ++ LS ++ + ++L I+RG DYYT IVFE+ V +GS+
Sbjct: 243 D---NESIKRVEDVFQHLSLLKIQDSFNLNLKISRGLDYYTGIVFESEVFGS-NMGSVCS 298
Query: 294 GGRYDNLIEVFGG--KPTPATGFAIGIERLIPILEWKGL----LPELKAGPDVFVIPVGD 347
GGRYDNL+ F + G + G++R+ I++ + + KA V ++ +
Sbjct: 299 GGRYDNLVSSFSNSIQKISGVGGSFGVDRIKDIIDLEKFSYIKIFVTKARSKVLIVNLDS 358
Query: 348 S-RDVATAIVTRLRKAGIRSDIELS---------GRKLRKALDYANRIGVRLSIIVGKRD 397
+ ++ + TR R +S G+ +++ ++YA +R + VG+ +
Sbjct: 359 ALQNYYYELATRFRNHDYSKVKNISCEVYFKNKNGKNIKEQIEYALSKEIRFLVFVGQEE 418
Query: 398 LERGVVTIRDLESGNQVEVPVDNVVTKVR 426
+ + +RDL ++ + + + ++
Sbjct: 419 YKENKMKVRDLTKKEELLLSFEESINLIK 447
>pdb|1HTT|A Chain A, Histidyl-Trna Synthetase >gi|1942450|pdb|1HTT|C Chain C,
Histidyl-Trna Synthetase >gi|1942449|pdb|1HTT|B Chain B,
Histidyl-Trna Synthetase >gi|1942451|pdb|1HTT|D Chain D,
Histidyl-Trna Synthetase
Length = 423
Score = 187 bits (470), Expect = 2e-46
Identities = 133/443 (30%), Positives = 224/443 (50%), Gaps = 39/443 (8%)
Query: 2 IERVKGTRDFLPEEMVKRRWVFEKIREVFETYGFKEVLTPVMEYTKLFQLRSGEE---VV 58
I+ ++G D+LP E + + ++ V +YG+ E+ P++E T LF+ GE V
Sbjct: 4 IQAIRGMNDYLPGETAIWQRIEGTLKNVLGSYGYSEIRLPIVEQTPLFKRAIGEVTDVVE 63
Query: 59 KQLYAFKDKGGRDVALRPDMTSSVARLYVNSFQTAPKPIKWYYIANMFRYEEPQSGRYRE 118
K++Y F+D+ G + LRP+ T+ R + + + +YI MFR+E PQ GRYR+
Sbjct: 64 KEMYTFEDRNGDSLTLRPEGTAGCVRAGIEHGLLYNQEQRLWYIGPMFRHERPQKGRYRQ 123
Query: 119 FWQAGVELIGSDKIEADAEVIALFVDSYLSTGLKDF-TVNIGDRVLLDEFAKMLGVKDDI 177
F Q G E+ G + DAE+I L + + G+ + T+ + L+ A D
Sbjct: 124 FHQLGCEVFGLQGPDIDAELIMLTARWWRALGISEHVTLELNSIGSLEARANYR----DA 179
Query: 178 GLMRIIDKKDKLSQE----EFLKALGEFGLDENGIEKVLNLIEIKGKPDDVLPLAEELFT 233
+ + K+KL ++ + L ++ +LN D L + L
Sbjct: 180 LVAFLEQHKEKLDEDCKRRMYTNPLRVLDSKNPEVQALLN---------DAPALGDYL-- 228
Query: 234 SERAKEEISRLYNLVDILSW-YEVDEWIQIDLGIARGFDYYTSIVFEAIVPNDLGI-GSI 291
E ++E + L L++ Y V++ + RG DYY VFE + N LG G++
Sbjct: 229 DEESREHFAGLCKLLESAGIAYTVNQ------RLVRGLDYYNRTVFEWVT-NSLGSQGTV 281
Query: 292 GGGGRYDNLIEVFGGKPTPATGFAIGIERLIPILEWKGLLPELKAGP--DVFVIPVG-DS 348
GGRYD L+E GG+ TPA GFA+G+ERL+ +++ + PE KA P D++++ G D+
Sbjct: 282 CAGGRYDGLVEQLGGRATPAVGFAMGLERLVLLVQ--AVNPEFKADPVVDIYLVASGADT 339
Query: 349 RDVATAIVTRLRK--AGIRSDIELSGRKLRKALDYANRIGVRLSIIVGKRDLERGVVTIR 406
+ A A+ RLR G++ G +K A++ G R+++++G+ ++ G ++
Sbjct: 340 QSAAMALAERLRDELPGVKLMTNHGGGNFKKQFARADKWGARVAVVLGESEVANGTAVVK 399
Query: 407 DLESGNQVEVPVDNVVTKVRELL 429
DL SG Q V D+V +R LL
Sbjct: 400 DLRSGEQTAVAQDSVAAHLRTLL 422
>sp|P04804|SYH_ECOLI HISTIDYL-TRNA SYNTHETASE (HISTIDINE--TRNA LIGASE) (HISRS)
>gi|68569|pir||SYECH histidine--tRNA ligase (EC
6.1.1.21) [validated] - Escherichia coli
>gi|2781068|pdb|1KMM|C Chain C, Histidyl-Trna Synthetase
Complexed With Histidyl-Adenylate >gi|2781066|pdb|1KMM|A
Chain A, Histidyl-Trna Synthetase Complexed With
Histidyl-Adenylate >gi|2781072|pdb|1KMN|C Chain C,
Histidyl-Trna Synthetase Complexed With Histidinol And
Atp >gi|2781070|pdb|1KMN|A Chain A, Histidyl-Trna
Synthetase Complexed With Histidinol And Atp
>gi|2781067|pdb|1KMM|B Chain B, Histidyl-Trna Synthetase
Complexed With Histidyl-Adenylate >gi|2781069|pdb|1KMM|D
Chain D, Histidyl-Trna Synthetase Complexed With
Histidyl-Adenylate >gi|2781071|pdb|1KMN|B Chain B,
Histidyl-Trna Synthetase Complexed With Histidinol And
Atp >gi|2781073|pdb|1KMN|D Chain D, Histidyl-Trna
Synthetase Complexed With Histidinol And Atp
>gi|146372|gb|AAA03226.1| (M11843) histidine-tRNA
synthetase [Escherichia coli] >gi|1788861|gb|AAC75567.1|
(AE000337) histidine tRNA synthetase [Escherichia coli
K12] >gi|1805574|dbj|BAA16401.1| (D90880)
histidine--tRNA ligase (EC 6.1.1.21) [Escherichia coli]
Length = 424
Score = 187 bits (470), Expect = 2e-46
Identities = 133/443 (30%), Positives = 224/443 (50%), Gaps = 39/443 (8%)
Query: 2 IERVKGTRDFLPEEMVKRRWVFEKIREVFETYGFKEVLTPVMEYTKLFQLRSGEE---VV 58
I+ ++G D+LP E + + ++ V +YG+ E+ P++E T LF+ GE V
Sbjct: 5 IQAIRGMNDYLPGETAIWQRIEGTLKNVLGSYGYSEIRLPIVEQTPLFKRAIGEVTDVVE 64
Query: 59 KQLYAFKDKGGRDVALRPDMTSSVARLYVNSFQTAPKPIKWYYIANMFRYEEPQSGRYRE 118
K++Y F+D+ G + LRP+ T+ R + + + +YI MFR+E PQ GRYR+
Sbjct: 65 KEMYTFEDRNGDSLTLRPEGTAGCVRAGIEHGLLYNQEQRLWYIGPMFRHERPQKGRYRQ 124
Query: 119 FWQAGVELIGSDKIEADAEVIALFVDSYLSTGLKDF-TVNIGDRVLLDEFAKMLGVKDDI 177
F Q G E+ G + DAE+I L + + G+ + T+ + L+ A D
Sbjct: 125 FHQLGCEVFGLQGPDIDAELIMLTARWWRALGISEHVTLELNSIGSLEARANYR----DA 180
Query: 178 GLMRIIDKKDKLSQE----EFLKALGEFGLDENGIEKVLNLIEIKGKPDDVLPLAEELFT 233
+ + K+KL ++ + L ++ +LN D L + L
Sbjct: 181 LVAFLEQHKEKLDEDCKRRMYTNPLRVLDSKNPEVQALLN---------DAPALGDYL-- 229
Query: 234 SERAKEEISRLYNLVDILSW-YEVDEWIQIDLGIARGFDYYTSIVFEAIVPNDLGI-GSI 291
E ++E + L L++ Y V++ + RG DYY VFE + N LG G++
Sbjct: 230 DEESREHFAGLCKLLESAGIAYTVNQ------RLVRGLDYYNRTVFEWVT-NSLGSQGTV 282
Query: 292 GGGGRYDNLIEVFGGKPTPATGFAIGIERLIPILEWKGLLPELKAGP--DVFVIPVG-DS 348
GGRYD L+E GG+ TPA GFA+G+ERL+ +++ + PE KA P D++++ G D+
Sbjct: 283 CAGGRYDGLVEQLGGRATPAVGFAMGLERLVLLVQ--AVNPEFKADPVVDIYLVASGADT 340
Query: 349 RDVATAIVTRLRK--AGIRSDIELSGRKLRKALDYANRIGVRLSIIVGKRDLERGVVTIR 406
+ A A+ RLR G++ G +K A++ G R+++++G+ ++ G ++
Sbjct: 341 QSAAMALAERLRDELPGVKLMTNHGGGNFKKQFARADKWGARVAVVLGESEVANGTAVVK 400
Query: 407 DLESGNQVEVPVDNVVTKVRELL 429
DL SG Q V D+V +R LL
Sbjct: 401 DLRSGEQTAVAQDSVAAHLRTLL 423
>sp|Q55653|SYH_SYNY3 HISTIDYL-TRNA SYNTHETASE (HISTIDINE--TRNA LIGASE) (HISRS)
>gi|7437811|pir||S76321 histidine--tRNA ligase (EC
6.1.1.21) - Synechocystis sp. (strain PCC 6803)
>gi|1001546|dbj|BAA10173.1| (D64000) histidyl-tRNA
synthetase [Synechocystis sp.]
Length = 447
Score = 186 bits (467), Expect = 5e-46
Identities = 139/451 (30%), Positives = 220/451 (47%), Gaps = 61/451 (13%)
Query: 2 IERVKGTRDFLPEEMVKRRWVFEKIREVFETYGFKEVLTPVMEYTKLFQLRSGEE---VV 58
I+ ++GTRD LP E +WV + + + ++E+ TP+ E T LF+ GE V
Sbjct: 4 IQAIRGTRDILPPETNYWQWVEAIAKSILDRALYQEIRTPIFEQTSLFERGIGEATDVVG 63
Query: 59 KQLYAFKDKGGRDVALRPDMTSSVARLYVN-SFQTAPKPIKWYYIANMFRYEEPQSGRYR 117
K++Y+F D+G R + LRP+ T+ V R Y+ + Q A + +Y MFRYE PQ+GR R
Sbjct: 64 KEMYSFTDRGDRPITLRPEGTAGVVRAYIEQNLQAAGGVQRLWYTGPMFRYERPQAGRQR 123
Query: 118 EFWQAGVELIGSDKIEADAEVIALFVDSYLSTGLKDFTV------NIGDRVLLDE--FAK 169
+F Q GVE++GS AD EVIAL D + GL + ++ N GDR E A
Sbjct: 124 QFHQLGVEVLGSADPRADVEVIALGTDILKALGLSNLSLALNSVGNGGDRQRYREALIAY 183
Query: 170 MLGVKDDI----------GLMRIIDKKDKLSQEEFLKALGEFGLDENGIEKVLNLIEIKG 219
+ K ++ +RI+D K K +QE A LD G++
Sbjct: 184 LTPFKAELDPDSQDRLERNPLRILDSKAKRTQEIVQDAPSI--LDHLGVD---------- 231
Query: 220 KPDDVLPLAEELFTSERAKEEISRLYNLVDILSWYEVDEWIQIDLGIARGFDYYTSIVFE 279
S+R +++ +L + I Q+ + RG DYYT FE
Sbjct: 232 --------------SQRHFDQVQQLLTNLGIA--------YQLTPTLVRGLDYYTHTAFE 269
Query: 280 AIVPNDLGI-GSIGGGGRYDNLIEVFGGKPTPATGFAIGIERLIPILEWKGLLPELKAGP 338
I +DLG ++ GGGRYD L+ GG TPA G+A+G+ERLI +L+ P P
Sbjct: 270 -IQSSDLGAQATVCGGGRYDGLVAELGGPVTPAVGWAMGLERLIILLQQMATPP--APSP 326
Query: 339 DVFVIPVGDSRD-VATAIVTRLRKAGIRSDIELSGRKLRKALDYANRIGVRLSIIVGKRD 397
D+++I G+ + A + +LR G+ ++LS K A++ G +++G +
Sbjct: 327 DLYLISKGEKAEPQALILAQKLRNQGLAVALDLSASAFGKQFKRADKSGAIACLVLGDGE 386
Query: 398 LERGVVTIRDLESGNQVEVPVDNVVTKVREL 428
+ G V ++ L Q + + +++ + EL
Sbjct: 387 IATGTVQLKWLADKAQETLQLQDLMGNITEL 417
>sp|P56194|SYH_THETH HISTIDYL-TRNA SYNTHETASE (HISTIDINE--TRNA LIGASE) (HISRS)
>gi|2392059|pdb|1ADJ|A Chain A, Histidyl-Trna Synthetase
In Complex With Histidine >gi|2392061|pdb|1ADJ|B Chain
B, Histidyl-Trna Synthetase In Complex With Histidine
>gi|2392063|pdb|1ADJ|C Chain C, Histidyl-Trna Synthetase
In Complex With Histidine >gi|2392065|pdb|1ADJ|D Chain
D, Histidyl-Trna Synthetase In Complex With Histidine
>gi|2392067|pdb|1ADY|A Chain A, Histidyl-Trna Synthetase
In Complex With Histidyl-Adenylate
>gi|2392068|pdb|1ADY|B Chain B, Histidyl-Trna Synthetase
In Complex With Histidyl-Adenylate
>gi|2392069|pdb|1ADY|C Chain C, Histidyl-Trna Synthetase
In Complex With Histidyl-Adenylate
>gi|2392070|pdb|1ADY|D Chain D, Histidyl-Trna Synthetase
In Complex With Histidyl-Adenylate
Length = 421
Score = 184 bits (463), Expect = 1e-45
Identities = 128/431 (29%), Positives = 217/431 (49%), Gaps = 38/431 (8%)
Query: 5 VKGTRDFLPEEMVKRRWVFEKIREVFETYGFKEVLTPVMEYTKLFQLRSG---EEVVKQL 61
V+GT+D +E+ + + R+V E G E++TP+ E T++F+ G + V K++
Sbjct: 6 VRGTKDLFGKELRMHQRIVATARKVLEAAGALELVTPIFEETQVFEKGVGAATDIVRKEM 65
Query: 62 YAFKDKGGRDVALRPDMTSSVARLYV-NSFQTAPKPIKWYYIANMFRYEEPQSGRYREFW 120
+ F+D+GGR + LRP+ T+++ R Y+ + + P+P++ + MFR E PQ GRYR+F
Sbjct: 66 FTFQDRGGRSLTLRPEGTAAMVRAYLEHGMKVWPQPVRLWMAGPMFRAERPQKGRYRQFH 125
Query: 121 QAGVELIGSDKIEADAEVIALFVDSYLSTGLKDFTVNIGDRVLLDEFAKMLGVKDDIGLM 180
Q E +GS+ DAE + L + GL+ V + +G +D
Sbjct: 126 QVNYEALGSENPILDAEAVVLLYECLKELGLRRLKVKLSS----------VGDPEDRARY 175
Query: 181 RIIDKKDKLSQEEFLKALGEFGLDENGIEKVLNLIEIKGKPDDVL-------PLAEELFT 233
++ E L + L+EN + +++ K + D L P+ + F
Sbjct: 176 NAYLREVLSPHREALSEDSKERLEENP----MRILDSKSERDQALLKELGVRPMLD--FL 229
Query: 234 SERAKEEISRLYNLVDILSW-YEVDEWIQIDLGIARGFDYYTSIVFEAIVPNDLGIGS-I 291
E A+ + + ++ LS YE++ + RG DYY FE + ++G S +
Sbjct: 230 GEEARAHLKEVERHLERLSVPYELEP------ALVRGLDYYVRTAFE-VHHEEIGAQSAL 282
Query: 292 GGGGRYDNLIEVFGGKPTPATGFAIGIERLIPILEWKGL-LPELKAGPDVFVIPVGDSRD 350
GGGGRYD L E+ GG P GFA G+ER+ LE +G LPE K GPD+++IP+ +
Sbjct: 283 GGGGRYDGLSELLGGPRVPGVGFAFGVERVALALEAEGFGLPEEK-GPDLYLIPLTEEAV 341
Query: 351 VATAIVTRLRKAGIRSDIELSGRKLRKALDYANRIGVRLSIIVGKRDLERGVVTIRDLES 410
+ + +R++ L+ RK K L+ A + G + +G+ +L G VT++ L +
Sbjct: 342 AEAFYLAEALRPRLRAEYALAPRKPAKGLEEALKRGAAFAGFLGEDELRAGEVTLKRLAT 401
Query: 411 GNQVEVPVDNV 421
G QV + + V
Sbjct: 402 GEQVRLSREEV 412
>gb|AAF48856.1| (AE003509) CG6335 gene product [Drosophila melanogaster]
Length = 522
Score = 184 bits (463), Expect = 1e-45
Identities = 127/462 (27%), Positives = 233/462 (49%), Gaps = 50/462 (10%)
Query: 6 KGTRDFLPEEMVKRRWVFEKIREVFETYGFKEVLTPVMEYTKLFQLRSGEEVVKQLYAFK 65
KGTRD+ P++M R+ V +KI +VF+ +G + + TPV E ++ + GE+ K +Y K
Sbjct: 63 KGTRDYGPQQMTLRQGVLDKIVQVFKRHGGEAIDTPVFELKEVLTGKYGED-SKLIYDLK 121
Query: 66 DKGGRDVALRPDMTSSVAR-LYVNSFQTAPKPIKWYYIANMFRYEEP--QSGRYREFWQA 122
D+GG +++R D+T +AR L +N + IK Y+IA ++R + P GRYREF+Q
Sbjct: 122 DQGGEILSMRYDLTVPLARYLAMNKISS----IKRYHIAKVYRRDNPAMTKGRYREFYQC 177
Query: 123 GVELIGS-DKIEADAEVIALFVDSYLSTGLKDFTVNIGDRVLLDEFAKMLGVKDDI--GL 179
++ G+ D + DAE + + + + + D+ + + R LLD + GV D +
Sbjct: 178 DFDIAGTYDPMLPDAECVKIVSEILDTLDIGDYVIKLNHRQLLDGMFQACGVPADSFRTI 237
Query: 180 MRIIDKKDKLSQEEFLKAL-GEFGLDENGIEKVLNLIEIKGKPDDVLPLAEELFTSERAK 238
+DK DK + K + E GLDE +++ + + G + L E+L +E+ K
Sbjct: 238 CSAVDKLDKSPWADVRKEMVDEKGLDEAAADRIGEYVRLSGGAE----LVEQLLANEKLK 293
Query: 239 ------EEISRLYNLVDILSWYEVDEWIQIDLGIARGFDYYTSIVFEAIVPNDLG----- 287
+ + + L+ S + +D+ + DL +ARG DYYT +++E ++ +
Sbjct: 294 AVPNAVKGLEGMKQLLKYCSIFGLDKRVSFDLSLARGLDYYTGVIYEGVLKGESATVASP 353
Query: 288 ----------------IGSIGGGGRYDNLIEVFG--GKPTPATGFAIGIERLIPILEWKG 329
+GS+ GGGRYDNL+ +F GK P G +IG+ER+ +LE +
Sbjct: 354 AKTSQQNGEQANEPATVGSVAGGGRYDNLVGMFDPRGKAVPCVGVSIGVERIFSVLEARA 413
Query: 330 LLPELKAGPDVFVIPVGDS----RDVATAIVTRLRKAGIRSDIELS-GRKLRKALDYANR 384
LK + V + + ++ L AG++++ KL L +
Sbjct: 414 AASGLKLRTSDVEVYVASAHKGLHEQRLKVLNLLWDAGVKAEHSYKLNPKLLVQLQHCEE 473
Query: 385 IGVRLSIIVGKRDLERGVVTIRDLESGNQVEVPVDNVVTKVR 426
+ L +++G +L +G+V +R++ + + V ++++ ++R
Sbjct: 474 HQIPLVVVLGDAELAQGLVKLREVTTREETNVKLEDLAAEIR 515
>sp|P46696|SYH_MYCLE HISTIDYL-TRNA SYNTHETASE (HISTIDINE--TRNA LIGASE) (HISRS)
>gi|2145854|pir||S72739 histidine--tRNA ligase (EC
6.1.1.21) syH - Mycobacterium leprae
>gi|466828|gb|AAA17103.1| (U00011) hisS; syH;
histidyl-tRNA synthetase; B1177_C3_248 [Mycobacterium
leprae]
Length = 427
Score = 184 bits (462), Expect = 2e-45
Identities = 139/441 (31%), Positives = 204/441 (45%), Gaps = 55/441 (12%)
Query: 6 KGTRDFLPEEMVKRRWVFEKIREVFETYGFKEVLTPVMEYTKLFQLRSGEE---VVKQLY 62
KG D+ P + + V + + G+ ++ PV E T LF GE V K++Y
Sbjct: 14 KGIPDYFPPDSAQFVAVRDGLLTAARRRGYGDIELPVFEDTALFARGVGESTDVVAKEMY 73
Query: 63 AFKDKGGRDVALRPDMTSSVARLYV-NSFQTAPKPIKWYYIANMFRYEEPQSGRYREFWQ 121
F D+G R V LRP+ T+ V R + + P+K Y FRYE PQ+GR R+ Q
Sbjct: 74 TFADRGDRSVTLRPEGTAGVVRAVIEHGLDRGALPVKLCYAGPFFRYERPQAGRCRQLQQ 133
Query: 122 AGVELIGSDKIEADAEVIALFVDSYLSTGLKDFTVNI---GD-------RVLLDEFAKML 171
GVE IG D DAEVI + + S GL F + I GD R LL EF L
Sbjct: 134 VGVEAIGVDDPALDAEVITIADAGFRSLGLDGFQLEITSLGDGTCRPQYRKLLQEFLLQL 193
Query: 172 GVKDD------IGLMRIIDKKDKLSQEEFLKALGEFGLDENGIEKVLNLIEIKGKPDDVL 225
+ +D + +R++D DK Q + + A LD
Sbjct: 194 DLDEDTRRRAELNPLRVLD--DKRPQVQAMTAAAPVLLDH-------------------- 231
Query: 226 PLAEELFTSERAKEEISRLYNLVDILSWYEVDEWIQIDLGIARGFDYYTSIVFEAIVPND 285
S+ AK+ + +D L V I+ + RG DYYT FE + P
Sbjct: 232 -------LSDGAKQHFDTVLAHLDALRVPYV-----INPRMVRGLDYYTKTTFEFVHPGL 279
Query: 286 LGIGSIGGGGRYDNLIEVFGGKPTPATGFAIGIERLIPILEWKGLLPELKAGPDVFVIPV 345
IGGGGRYD L+ GG+ GF +G++R + L +G DVF + +
Sbjct: 280 GAQSGIGGGGRYDGLMRQLGGQDLSGIGFGLGVDRTLLALHAEGKTVGETTRCDVFGVSL 339
Query: 346 GDSRDVATAIVT-RLRKAGIRSDIELSGRKLRKALDYANRIGVRLSIIVGKRDLERGVVT 404
G++ + A++ +LR AG+R D+ R +R A+ A R G R+++IV ++ V
Sbjct: 340 GEAAKLKVAMLAGQLRAAGVRVDLIYGDRGIRGAMRAAGRSGARIALIVDDCAIKADGVG 399
Query: 405 IRDLESGNQVEVPVDNVVTKV 425
+RDL +G Q+ V VD+VV +V
Sbjct: 400 VRDLATGEQISVAVDSVVAEV 420
>emb|CAA19087.1| (AL023591) histidyl-tRNA synthetase [Mycobacterium leprae]
Length = 427
Score = 184 bits (462), Expect = 2e-45
Identities = 139/441 (31%), Positives = 204/441 (45%), Gaps = 55/441 (12%)
Query: 6 KGTRDFLPEEMVKRRWVFEKIREVFETYGFKEVLTPVMEYTKLFQLRSGEE---VVKQLY 62
KG D+ P + + V + + G+ ++ PV E T LF GE V K++Y
Sbjct: 14 KGIPDYFPPDSAQFVAVRDGLLTAARRAGYGDIELPVFEDTALFARGVGESTDVVAKEMY 73
Query: 63 AFKDKGGRDVALRPDMTSSVARLYV-NSFQTAPKPIKWYYIANMFRYEEPQSGRYREFWQ 121
F D+G R V LRP+ T+ V R + + P+K Y FRYE PQ+GR R+ Q
Sbjct: 74 TFADRGDRSVTLRPEGTAGVVRAVIEHGLDRGALPVKLCYAGPFFRYERPQAGRCRQLQQ 133
Query: 122 AGVELIGSDKIEADAEVIALFVDSYLSTGLKDFTVNI---GD-------RVLLDEFAKML 171
GVE IG D DAEVI + + S GL F + I GD R LL EF L
Sbjct: 134 VGVEAIGVDDPALDAEVITIADAGFRSLGLDGFQLEITSLGDGTCRPQYRKLLQEFLLQL 193
Query: 172 GVKDD------IGLMRIIDKKDKLSQEEFLKALGEFGLDENGIEKVLNLIEIKGKPDDVL 225
+ +D + +R++D DK Q + + A LD
Sbjct: 194 DLDEDTRRRAELNPLRVLD--DKRPQVQAMTAAAPVLLDH-------------------- 231
Query: 226 PLAEELFTSERAKEEISRLYNLVDILSWYEVDEWIQIDLGIARGFDYYTSIVFEAIVPND 285
S+ AK+ + +D L V I+ + RG DYYT FE + P
Sbjct: 232 -------LSDGAKQHFDTVLAHLDALRVPYV-----INPRMVRGLDYYTKTTFEFVHPGL 279
Query: 286 LGIGSIGGGGRYDNLIEVFGGKPTPATGFAIGIERLIPILEWKGLLPELKAGPDVFVIPV 345
IGGGGRYD L+ GG+ GF +G++R + L +G DVF + +
Sbjct: 280 GAQSGIGGGGRYDGLMRQLGGQDLSGIGFGLGVDRTLLALHAEGKTVGETTRCDVFGVSL 339
Query: 346 GDSRDVATAIVT-RLRKAGIRSDIELSGRKLRKALDYANRIGVRLSIIVGKRDLERGVVT 404
G++ + A++ +LR AG+R D+ R +R A+ A R G R+++IV ++ V
Sbjct: 340 GEAAKLKVAMLAGQLRAAGVRVDLIYGDRGIRGAMRAAGRSGARIALIVDDCAIKADGVG 399
Query: 405 IRDLESGNQVEVPVDNVVTKV 425
+RDL +G Q+ V VD+VV +V
Sbjct: 400 VRDLATGEQISVAVDSVVAEV 420
>gi|11465814 histidine tRNA synthetase [Porphyra purpurea]
>gi|1711633|sp|P51348|SYH_PORPU HISTIDYL-TRNA SYNTHETASE
(HISTIDINE--TRNA LIGASE) (HISRS) >gi|2147478|pir||S73269
histidine--tRNA ligase (EC 6.1.1.21) - red alga
(Porphyra purpurea) chloroplast
>gi|1276814|gb|AAC08234.1| (U38804) histidine tRNA
synthetase [Porphyra purpurea]
Length = 430
Score = 183 bits (460), Expect = 3e-45
Identities = 124/432 (28%), Positives = 211/432 (48%), Gaps = 23/432 (5%)
Query: 2 IERVKGTRDFLPEEMVKRRWVFEKIREVFETYGFKEVLTPVMEYTKLFQLRSGEE---VV 58
I+ ++GT+D LP+E + +++ EK+ + + +KE+ TP+ E + L+ GE V
Sbjct: 4 IQAIRGTKDILPDEQLYWQFIHEKVASLLKYANYKEIKTPIFENSDLYDRGIGENTDIVN 63
Query: 59 KQLYAFKDKGGRDVALRPDMTSSVARLYV-NSFQTAPKPIKWYYIANMFRYEEPQSGRYR 117
K++Y F D+ RD+ LRP+ T+ V R ++ N + K +Y MFRYE PQSGR R
Sbjct: 64 KEMYRFNDRSNRDITLRPEGTAGVVRAFIENRMDVQNRLQKLWYSGPMFRYERPQSGRQR 123
Query: 118 EFWQAGVELIGSDKIEADAEVIALFVDSYLSTGLKDFTVNIGDRVLLDEFAKMLGVKDDI 177
+F Q G+E IGS ADAE+I L ++ + + D ++I + + E K
Sbjct: 124 QFHQLGIEFIGSSDARADAEIIHLAMNIFNDLSVNDLQLDI-NSIGKAEDRNHYQAKLQE 182
Query: 178 GLMRIIDKKDKLSQEEFLKALGEFGLDENGIEKVLNLIEIKGKPDDVLPLAEELFTSERA 237
L + D D SQ L N I +++ K K + + +
Sbjct: 183 YLEQYYDDLDTDSQNR---------LSSNPI----RILDTKNKYTQTILNDSPRISDFLS 229
Query: 238 KEEISRLYNLVDILSWYEVDEWIQIDLGIARGFDYYTSIVFEAIVPNDLGIGSIGGGGRY 297
E ++ D L+ V +I+ + RG DYY FE + G ++ GGGRY
Sbjct: 230 LESEKHFDDVCDYLTLLNVP--YKINTQLVRGLDYYNDTAFEIKILKSQGQDTLCGGGRY 287
Query: 298 DNLIEVFGGKPTPATGFAIGIERLIPILEWKGLLPELKAGPDVFVIPVG-DSRDVATAIV 356
D+LI GG TPA G AIG+ERL+ + + LLP + D +++ G +R + I
Sbjct: 288 DSLIHQLGGNKTPAVGCAIGLERLLLVAKDNILLPHMSI--DCYIVSKGIKARKIGIIIT 345
Query: 357 TRLRKAGIRSDIELSGRKLRKALDYANRIGVRLSIIVGKRDLERGVVTIRDLESGNQVEV 416
LR +++++++S K L A++ +I+G ++++ +TI+ + + Q +
Sbjct: 346 QFLRNQLVKTELDISSSNFGKQLKQAHKKRAIACLILGDNEIQQETITIKWMYTQEQENM 405
Query: 417 PVDNVVTKVREL 428
+ K+ L
Sbjct: 406 SIIEFKNKISYL 417
>gi|6325290 cytoplasmic and mitochondrial histidine tRNA synthetases; Hts1p
[Saccharomyces cerevisiae]
>gi|2507433|sp|P07263|SYH_YEAST HISTIDYL-TRNA
SYNTHETASE, MITOCHONDRIAL PRECURSOR (HISTIDINE--TRNA
LIGASE) (HISRS) >gi|2144561|pir||SYBYHM histidine--tRNA
ligase (EC 6.1.1.21) - yeast (Saccharomyces cerevisiae)
>gi|809598|emb|CAA89287.1| (Z49274) Hts1p [Saccharomyces
cerevisiae] >gi|1314107|emb|CAA94983.1| (Z71255) Hts1p
[Saccharomyces cerevisiae]
Length = 546
Score = 180 bits (451), Expect = 4e-44
Identities = 133/479 (27%), Positives = 237/479 (48%), Gaps = 60/479 (12%)
Query: 6 KGTRDFLPEEMVKRRWVFEKIREVFETYGFKEVLTPVMEYTKLFQLRSGEEVVKQLYAFK 65
KGT+D+ +MV R +F + +F+ +G + TPV E ++ + GE+ K +Y +
Sbjct: 59 KGTKDWADSDMVIREAIFSTLSGLFKKHGGVTIDTPVFELREILAGKYGEDS-KLIYNLE 117
Query: 66 DKGGRDVALRPDMTSSVAR-LYVNSFQTAPKPIKWYYIANMFRYEEPQ--SGRYREFWQA 122
D+GG +LR D+T AR + +N+ Q+ IK Y+IA ++R ++P GR REF+Q
Sbjct: 118 DQGGELCSLRYDLTVPFARYVAMNNIQS----IKRYHIAKVYRRDQPAMTKGRMREFYQC 173
Query: 123 GVELIGS-DKIEADAEVIALFVDSYLSTGLKDFTVNIGDRVLLDEFAKMLGVKDDI--GL 179
++ G+ + + D+E +++ V+ S G+KDF + + R +LD ++ GVKD+ +
Sbjct: 174 DFDVAGTFESMVPDSECLSILVEGLTSLGIKDFKIKLNHRKILDGIFQIAGVKDEDVRKI 233
Query: 180 MRIIDKKDKLSQEEFLKALGEF-GLDENGIEKVLNLIEIKGKPDD---VLPLAEELFTSE 235
+DK DK E K + E G E +K+ +++ G + VL + ++E
Sbjct: 234 SSAVDKLDKSPWEAVKKEMTEEKGQSEETADKIGEYVKLNGSLKEIHAVLSADANITSNE 293
Query: 236 RAKEEISRLYNLVDILSWYEVDEWIQIDLGIARGFDYYTSIVFEAIVPND---------- 285
+AK+ + + L+ +++D +I DL +ARG DYYT +++E +
Sbjct: 294 KAKQGLDDIATLMKYTEAFDIDSFISFDLSLARGLDYYTGLIYEVVTSASAPPENASELK 353
Query: 286 ------------LGIGSIGGGGRYDNLIEVF----GGKPT--PATGFAIGIERLIPILEW 327
+G+GSI GGRYDNL+ +F G K T P G + G+ER+ +++
Sbjct: 354 KKAKSAEDASEFVGVGSIAAGGRYDNLVNMFSEASGKKSTQIPCVGISFGVERIFSLIKQ 413
Query: 328 K--GLLPELKAGPDVFVIPVGDSRDVATAIVTRLR------KAGIRSDIELSGR-KLRKA 378
+ VFV+ G +D + R++ AGI ++ + RK
Sbjct: 414 RINSSTTIKPTATQVFVMAFGGGKDWTGYLPERMKVTKQLWDAGIEAEYVYKAKANPRKQ 473
Query: 379 LDYANRIGVRLSIIVGKRDLERGVVTIRDL------ESGNQVEVPVDNVVTKVRELLNQ 431
D A + G +++I+GK + G + ++ L + G V ++V V+E L+Q
Sbjct: 474 FDAAEKAGCHIAVILGKEEYLEGKLRVKRLGQEFADDDGELVSAA--DIVPIVQEKLSQ 530
>sp|O52765|SYH_SALTY HISTIDYL-TRNA SYNTHETASE (HISTIDINE--TRNA LIGASE) (HISRS)
>gi|2896164|gb|AAC03121.1| (AF047040) histidyl-tRNA
synthetase; aminoacyl-tRNA synthetase [Salmonella
typhimurium]
Length = 424
Score = 179 bits (450), Expect = 5e-44
Identities = 135/446 (30%), Positives = 224/446 (49%), Gaps = 45/446 (10%)
Query: 2 IERVKGTRDFLPEEMVKRRWVFEKIREVFETYGFKEVLTPVMEYTKLFQLRSGEE---VV 58
I+ ++G D+LP E + + ++ V +YG+ E+ P++E T LF+ GE V
Sbjct: 5 IQAIRGMNDYLPGETAIWQRIEGTLKNVLGSYGYSEIRLPIVEQTPLFKRAIGEVTDVVE 64
Query: 59 KQLYAFKDKGGRDVALRPDMTSSVARLYVNSFQTAPKPIKWYYIANMFRYEEPQSGRYRE 118
K++Y F+D+ G + LRP+ T+ R + + + +YI MFR+E PQ GRYR+
Sbjct: 65 KEMYTFEDRNGDSLTLRPEGTAGCVRAGIEHGLLYNQEQRLWYIGPMFRHERPQKGRYRQ 124
Query: 119 FWQAGVELIGSDKIEADAEVIALFVDSYLSTGLKDFTVNIGDRVLLDEFAKMLGVKDDIG 178
F Q G E+ G + DAE+I L + + G I + V L+ + IG
Sbjct: 125 FHQLGAEVFGLQGPDIDAELIMLTARWWRALG-------IAEHVSLE--------LNSIG 169
Query: 179 LMRI-IDKKDKLSQEEFLKALGEFGLDENGIEKVLN--LIEIKGKPDDVLPLAEEL---- 231
+ + +D L FL+ E LDE+ ++ L + K DV L +
Sbjct: 170 SLEARANYRDALVA--FLEQHQET-LDEDCKRRMYTNPLRVLDSKNPDVQALLNDAPALG 226
Query: 232 -FTSERAKEEISRLYNLVDILSW-YEVDEWIQIDLGIARGFDYYTSIVFEAIVPNDLGI- 288
+ + ++E + L L+D Y V++ + RG DYY VFE + N LG
Sbjct: 227 DYLDDDSREHFAGLCKLLDAAGIAYTVNQ------RLVRGLDYYNRTVFEWVT-NSLGSQ 279
Query: 289 GSIGGGGRYDNLIEVFGGKPTPATGFAIGIERLIPILEWKGLLPELKAGP--DVFVIPVG 346
G++ GGRYD L+E GG+ TPA GFA+G+ERL+ +++ + PE A P D++++ G
Sbjct: 280 GTVCAGGRYDGLVEQLGGRATPAVGFAMGLERLVLLVQ--AVNPEFIASPVVDIYLVAAG 337
Query: 347 -DSRDVATAIVTRLR--KAGIRSDIELSGRKLRKALDYANRIGVRLSIIVGKRDLERGVV 403
++ A + RLR G++ G +K A++ G R+++++G+ ++ G V
Sbjct: 338 AQTQSAAMTLAERLRDEMPGVKLMTNHGGGNFKKQFARADKWGARIALVLGESEVADGTV 397
Query: 404 TIRDLESGNQVEVPVDNVVTKVRELL 429
++DL SG Q V D+V +R L
Sbjct: 398 VVKDLRSGEQTAVAQDSVAAHLRTYL 423
>gb|AAA34695.1| (M14048) histidine-tRNA synthetase mitochondrial [Saccharomyces
cerevisiae]
Length = 546
Score = 178 bits (447), Expect = 1e-43
Identities = 132/479 (27%), Positives = 236/479 (48%), Gaps = 60/479 (12%)
Query: 6 KGTRDFLPEEMVKRRWVFEKIREVFETYGFKEVLTPVMEYTKLFQLRSGEEVVKQLYAFK 65
KGT+D+ +MV R +F + +F+ +G + TPV E ++ + GE+ K +Y +
Sbjct: 59 KGTKDWADSDMVIREAIFSTLSGLFKKHGGVTIDTPVFELREILAGKYGEDS-KLIYNLE 117
Query: 66 DKGGRDVALRPDMTSSVAR-LYVNSFQTAPKPIKWYYIANMFRYEEPQ--SGRYREFWQA 122
D+GG +LR D+T AR + +N+ Q+ IK Y+IA ++R ++P GR REF+Q
Sbjct: 118 DQGGELCSLRYDLTVPFARYVAMNNIQS----IKRYHIAKVYRRDQPAMTKGRMREFYQC 173
Query: 123 GVELIGS-DKIEADAEVIALFVDSYLSTGLKDFTVNIGDRVLLDEFAKMLGVKDDI--GL 179
++ G+ + + D+E +++ V+ S G+KDF + + R +LD ++ GVKD+ +
Sbjct: 174 DFDVAGTFESMVPDSECLSILVEGLTSLGIKDFKIKLNHRKILDGIFQIAGVKDEDVRKI 233
Query: 180 MRIIDKKDKLSQEEFLKALGEF-GLDENGIEKVLNLIEIKGKPDD---VLPLAEELFTSE 235
+DK DK E K + E G E +K+ +++ G + VL + ++E
Sbjct: 234 SSAVDKLDKSPWEAVKKEMTEEKGQSEETADKIGEYVKLNGSLKEIHAVLSADANITSNE 293
Query: 236 RAKEEISRLYNLVDILSWYEVDEWIQIDLGIARGFDYYTSIVFEAIVPND---------- 285
+AK+ + + L+ +++D +I DL +ARG DYYT +++E +
Sbjct: 294 KAKQGLDDIATLMKYTEAFDIDSFISFDLSLARGLDYYTGLIYEVVTSASAPPENASELK 353
Query: 286 ------------LGIGSIGGGGRYDNLIEVF----GGKPT--PATGFAIGIERLIPILEW 327
+G+GSI GGRYDNL+ +F G K T P G + G+ER+ +++
Sbjct: 354 KKAKSAEDASEFVGVGSIAAGGRYDNLVNMFSEASGKKSTQIPCVGISFGVERIFSLIKQ 413
Query: 328 K--GLLPELKAGPDVFVIPVGDSRDVATAIVTRLR------KAGIRSDIELSGR-KLRKA 378
+ VFV+ G +D + R++ AGI ++ + RK
Sbjct: 414 RINSSTTIKPTATQVFVMAFGGGKDWTGYLPERMKVTKQLWDAGIEAEYVYKAKANPRKQ 473
Query: 379 LDYANRIGVRLSIIVGKRDLERGVVTIRDL------ESGNQVEVPVDNVVTKVRELLNQ 431
D + G +++I+GK + G + ++ L + G V ++V V+E L+Q
Sbjct: 474 FDTTKKAGCHIAVILGKEEYLEGKLRVKRLGQEFADDDGELVSAA--DIVPIVQEKLSQ 530
>pir||SYBYHC histidine--tRNA ligase (EC 6.1.1.21), cytosolic - yeast
(Saccharomyces cerevisiae) >gi|171733|gb|AAA34696.1|
(M14048) histidine-tRNA synthetase cytoplasmic
[Saccharomyces cerevisiae]
Length = 526
Score = 178 bits (447), Expect = 1e-43
Identities = 132/479 (27%), Positives = 236/479 (48%), Gaps = 60/479 (12%)
Query: 6 KGTRDFLPEEMVKRRWVFEKIREVFETYGFKEVLTPVMEYTKLFQLRSGEEVVKQLYAFK 65
KGT+D+ +MV R +F + +F+ +G + TPV E ++ + GE+ K +Y +
Sbjct: 39 KGTKDWADSDMVIREAIFSTLSGLFKKHGGVTIDTPVFELREILAGKYGEDS-KLIYNLE 97
Query: 66 DKGGRDVALRPDMTSSVAR-LYVNSFQTAPKPIKWYYIANMFRYEEPQ--SGRYREFWQA 122
D+GG +LR D+T AR + +N+ Q+ IK Y+IA ++R ++P GR REF+Q
Sbjct: 98 DQGGELCSLRYDLTVPFARYVAMNNIQS----IKRYHIAKVYRRDQPAMTKGRMREFYQC 153
Query: 123 GVELIGS-DKIEADAEVIALFVDSYLSTGLKDFTVNIGDRVLLDEFAKMLGVKDDI--GL 179
++ G+ + + D+E +++ V+ S G+KDF + + R +LD ++ GVKD+ +
Sbjct: 154 DFDVAGTFESMVPDSECLSILVEGLTSLGIKDFKIKLNHRKILDGIFQIAGVKDEDVRKI 213
Query: 180 MRIIDKKDKLSQEEFLKALGEF-GLDENGIEKVLNLIEIKGKPDD---VLPLAEELFTSE 235
+DK DK E K + E G E +K+ +++ G + VL + ++E
Sbjct: 214 SSAVDKLDKSPWEAVKKEMTEEKGQSEETADKIGEYVKLNGSLKEIHAVLSADANITSNE 273
Query: 236 RAKEEISRLYNLVDILSWYEVDEWIQIDLGIARGFDYYTSIVFEAIVPND---------- 285
+AK+ + + L+ +++D +I DL +ARG DYYT +++E +
Sbjct: 274 KAKQGLDDIATLMKYTEAFDIDSFISFDLSLARGLDYYTGLIYEVVTSASAPPENASELK 333
Query: 286 ------------LGIGSIGGGGRYDNLIEVF----GGKPT--PATGFAIGIERLIPILEW 327
+G+GSI GGRYDNL+ +F G K T P G + G+ER+ +++
Sbjct: 334 KKAKSAEDASEFVGVGSIAAGGRYDNLVNMFSEASGKKSTQIPCVGISFGVERIFSLIKQ 393
Query: 328 K--GLLPELKAGPDVFVIPVGDSRDVATAIVTRLR------KAGIRSDIELSGR-KLRKA 378
+ VFV+ G +D + R++ AGI ++ + RK
Sbjct: 394 RINSSTTIKPTATQVFVMAFGGGKDWTGYLPERMKVTKQLWDAGIEAEYVYKAKANPRKQ 453
Query: 379 LDYANRIGVRLSIIVGKRDLERGVVTIRDL------ESGNQVEVPVDNVVTKVRELLNQ 431
D + G +++I+GK + G + ++ L + G V ++V V+E L+Q
Sbjct: 454 FDTTKKAGCHIAVILGKEEYLEGKLRVKRLGQEFADDDGELVSAA--DIVPIVQEKLSQ 510
>sp|P49590|SYHH_HUMAN HISTIDYL-TRNA SYNTHETASE HOMOLOG (HISTIDINE--TRNA LIGASE HOMOLOG)
(HISRS) >gi|7437808|pir||I38915 histidyl-tRNA synthetase
homolog - human >gi|899109|gb|AAA73974.1| (U18937)
histidyl-tRNA synthetase homologue [Homo sapiens]
Length = 506
Score = 176 bits (443), Expect = 3e-43
Identities = 128/458 (27%), Positives = 226/458 (48%), Gaps = 35/458 (7%)
Query: 1 MIERVKGTRDFLPEEMVKRRWVFEKIREVFETYGFKEVLTPVMEYTKLFQLRSGEEVVKQ 60
+I+ KGTRD P+ MV R + + + F+ +G K + TP E + + GE+
Sbjct: 56 IIKTPKGTRDLSPQHMVVREKILDLVISCFKRHGAKGMDTPAFELKETLTEKYGEDS-GL 114
Query: 61 LYAFKDKGGRDVALRPDMTSSVARLYVNSFQTAPKPIKWYYIANMFRYEEPQ--SGRYRE 118
+Y KD+GG ++LR D+T AR K +K Y++ ++R E P GRYRE
Sbjct: 115 MYDLKDQGGELLSLRYDLTVPFARYLA---MNKVKKMKRYHVGKVWRRESPTIVQGRYRE 171
Query: 119 FWQAGVELIGS-DKIEADAEVIALFVDSYLSTGLKDFTVNIGDRVLLDEFAKMLGVKDDI 177
F Q ++ G D + DAE + + + L DF + + DR ++D + GV +
Sbjct: 172 FCQCDFDIAGQFDPMIPDAECLKIMCEILSGLQLGDFLIKVNDRRIVDGMFAVCGVPESK 231
Query: 178 --GLMRIIDKKDKLSQEEFL-KALGEFGLDENGIEKVLNLIEIKGKPDDVLPLAEELFTS 234
+ IDK DK++ ++ + + + GL +++ + ++ G + L E++F
Sbjct: 232 FRAICSSIDKLDKMAWKDVRHEMVVKKGLAPEVADRIGDYVQCHGG----VSLVEQMFQD 287
Query: 235 ERAKEEISRLYNLVDI------LSWYEVDEWIQIDLGIARGFDYYTSIVFEAIV------ 282
R + L L D+ L+ + + + I DL +ARG DYYT +++EA++
Sbjct: 288 PRLSQNKQALEGLGDLKLLFEYLTLFGIADKISFDLSLARGLDYYTGVIYEAVLLQTPTQ 347
Query: 283 --PNDLGIGSIGGGGRYDNLIEVFG--GKPTPATGFAIGIERLIPILEWKGLLPELKAGP 338
L +GS+ GGRYD L+ +F G P G +IG+ER+ I+E + K
Sbjct: 348 AGEEPLNVGSVAAGGRYDGLVGMFDPKGHKVPCVGLSIGVERIFYIVEQRMKTKGEKVRT 407
Query: 339 ---DVFVI-PVGDSRDVATAIVTRLRKAGIRSDIELSGR-KLRKALDYANRIGVRLSIIV 393
VFV P + ++ L +GI++++ KL L Y G+ L +I+
Sbjct: 408 TETQVFVATPQKNFLQERLKLIAELWDSGIKAEMLYKNNPKLLTQLHYCESTGIPLVVII 467
Query: 394 GKRDLERGVVTIRDLESGNQVEVPVDNVVTKVRELLNQ 431
G+++L+ GV+ IR + S +V + +N V ++++ L++
Sbjct: 468 GEQELKEGVIKIRSVASREEVAIKRENFVAEIQKRLSE 505
>pir||T24848 hypothetical protein T11G6.1 - Caenorhabditis elegans
>gi|3879781|emb|CAA93416.1| (Z69384) predicted using
Genefinder~Similarity to C.elegans Histidyl-tRNA
synthetase (SW:SYH_CAEEL), contains similarity to Pfam
domain: PF00587 (tRNA synthetase class II (G, H, P, S
and T)), Score=103.4, E-value=1.5e-27, N=1~cDNA EST
yk132e4.3 comes f>
Length = 520
Score = 176 bits (443), Expect = 3e-43
Identities = 134/459 (29%), Positives = 231/459 (50%), Gaps = 41/459 (8%)
Query: 6 KGTRDFLPEEMVKRRWVFEKIREVFETYGFKEVLTPVMEYTKLFQLRSGEEVVKQLYAFK 65
KGTRD+ P + R V + + E F YG + + TPV E + + GEE K +Y +
Sbjct: 65 KGTRDYGPAQSALRNSVLQTVTETFNRYGAETIDTPVFELRDVLMGKYGEEGGKLVYDLQ 124
Query: 66 DKGGRDVALRPDMTSSVAR-LYVNSFQTAPKPIKWYYIANMFRYEEP--QSGRYREFWQA 122
D+GG ++LR D+T AR L +N I Y IA ++R ++P GRYREF+Q
Sbjct: 125 DQGGELLSLRYDLTVPFARYLAMNKITN----ITRYQIAKVYRRDQPVMSRGRYREFYQC 180
Query: 123 GVELIGS-DKIEADAEVIALFVDSYLSTGLKDFTVNIGDRVLLDEFAKMLGV--KDDIGL 179
++ G D + +AE + + + + +F +N+ R++L+ + G+ KD +
Sbjct: 181 DFDIAGQYDLMLPEAECLGIVDELLTKLEIGEFFINLNHRLILEGMFAVSGIPAKDFKTI 240
Query: 180 MRIIDKKDKLSQEEF-LKALGEFGLDENGIEKVLNLIEIKGKPDDV--LPLAE------E 230
+DK DK E+ + + E L + K+ L+ + D+ L L E +
Sbjct: 241 CSSVDKLDKTPWEDVEQEMINEKFLTKEQTGKLGELVRFRELNSDLNNLELLEKMSQLPD 300
Query: 231 LFTSERAKEEISRLYNLVDILSWYEVDEWIQIDLGIARGFDYYTSIVFEAIVPNDL---- 286
L +++ K+ L L++ L+ V ++ + +ARG DYYT ++EA+ P L
Sbjct: 301 LGQNDKFKKGAEELKVLIEYLNVDGVTT-VRYEPSLARGLDYYTGAIYEAVAPKALEGTA 359
Query: 287 ------------GIGSIGGGGRYDNLIEVFGGKP-TPATGFAIGIERLIPILEWKGLLPE 333
G+GS+ GGRYD L+++F K P G + GIERL I+E + +
Sbjct: 360 VENSEDTAGQPVGVGSVAAGGRYDGLVKMFDSKANVPCCGVSFGIERLFAIMEARQKVAI 419
Query: 334 LKAGPDVFVIPVGDS--RDVATAIVTRLRKAGIRSDIELSGR-KLRKALDYANRIGVRLS 390
+V+V + RD +V LR AGI++++ L KL YA + L+
Sbjct: 420 RTTQTEVYVASAQKNLVRD-RKKLVKMLRSAGIKTEMALKANPKLLTQFQYAEERRIPLA 478
Query: 391 IIVGKRDLERGVVTIRDLESGNQVEVPVDNVVTKVRELL 429
I++G+++L+ GVV +R++ + ++ + +D ++T VR+ L
Sbjct: 479 IVIGEQELKDGVVKLRNVVTRDEQTIKLDQLITAVRDTL 517
>pir||T40151 histidine-tRNA ligase precursor, mitochondrial - fission yeast
(Schizosaccharomyces pombe) >gi|2956779|emb|CAA17892.1|
(AL022103) histidyl-trna synthetase, mitochondrial
precursor [Schizosaccharomyces pombe]
Length = 538
Score = 173 bits (435), Expect = 3e-42
Identities = 134/473 (28%), Positives = 241/473 (50%), Gaps = 53/473 (11%)
Query: 6 KGTRDFLPEEMVKRRWVFEKIREVFETYGFKEVLTPVMEYTKLFQLRSGEEVVKQLYAFK 65
KGT+D+ +++V R +F + E+F+ +G + TPV E ++ + GE+ K +Y K
Sbjct: 67 KGTKDWCDKDVVLREHIFSTVTEIFKRHGGVTLDTPVFELKEILSGKYGED-SKLIYDLK 125
Query: 66 DKGGRDVALRPDMTSSVAR-LYVNSFQTAPKPIKWYYIANMFRYEEP--QSGRYREFWQA 122
D+GG +LR D+T AR L +N T+ IK ++IA ++R ++P GR REF+Q
Sbjct: 126 DQGGELCSLRYDLTVPFARWLAMNPKVTS---IKRFHIAKVYRRDQPAMTKGRMREFYQC 182
Query: 123 GVELIGS-DKIEADAEVIALFVDSYLSTGLKDFTVNIGDRVLLDEFAKMLGVKDD--IGL 179
++ G+ D + D+E + + V++ + + ++T+ + R +LD + GV DD +
Sbjct: 183 DFDIAGNYDPMIPDSEALKVLVEALDALEVGNYTIKLNHRKILDGIFTVCGVPDDKIRTI 242
Query: 180 MRIIDKKDKLSQEEFLKAL-GEFGLDENGIEKVLNLIEIKGKPD--DVLPLAEELFTSER 236
+DK DKL E+ + + E GL E +K+ + +KG D L L ++
Sbjct: 243 SSAVDKLDKLPWEDVRREMVVEKGLKEEVADKIKEYVLLKGDRSLLDKLEADSLLSSNSS 302
Query: 237 AKEEISRLYNLVDILSWYEVDEWIQIDLGIARGFDYYTSIVFEAIV-------------- 282
A + + L D L + V + D+ +ARG DYYT I++EA+
Sbjct: 303 AVAAFNDMRLLFDYLEAFGVLDRFSFDMSLARGLDYYTGIIYEAVTEASAPKIKSSAEKK 362
Query: 283 -----------PNDLGIGSIGGGGRYDNLIEVFGGKPT---PATGFAIGIERLIPILEWK 328
+ +G+GSI GGRYDNL+ +F K P G ++G+ER+ IL K
Sbjct: 363 KSADPEADRSNDDSIGVGSIAAGGRYDNLVGMFAAKKNAKIPCVGISLGLERIFSILRSK 422
Query: 329 GLLPELKAGP-DVFVIPVGDSRDVATAIVTRLRKA------GIRSDIELSGR-KLRKALD 380
+++A DVFV+ G ++ + R+ GI+++ + K R+ D
Sbjct: 423 IPDEDIRANDVDVFVMAFGGGKEWTGFLKERMSVCKDLWANGIKAEFLYKVKPKPRQQFD 482
Query: 381 YANRIGVRLSIIVGKRDLERGVVTIRDL---ESGNQVE-VPVDNVVTKVRELL 429
A++ V ++I+G+ + +G V I+ + E+ ++ + VP + +V+ +++LL
Sbjct: 483 AADKFDVPFAVILGQDEFAKGSVRIKQMGLKENSDEGQLVPREEMVSVLKKLL 535
>pir||G82283 histidyl-tRNA synthetase VC0760 [imported] - Vibrio cholerae (group
O1 strain N16961) >gi|9655206|gb|AAF93925.1| (AE004161)
histidyl-tRNA synthetase [Vibrio cholerae]
Length = 422
Score = 173 bits (433), Expect = 5e-42
Identities = 121/424 (28%), Positives = 212/424 (49%), Gaps = 34/424 (8%)
Query: 2 IERVKGTRDFLPEEMVKRRWVFEKIREVFETYGFKEVLTPVMEYTKLFQLRSGEE---VV 58
I+ ++G D LP + + V ++ V YG+ EV P++E T LF GE V
Sbjct: 5 IQAIRGMNDCLPTQSPLWQKVEGVVKNVISAYGYSEVRMPIVEMTHLFSRAIGEVTDVVE 64
Query: 59 KQLYAFKDKGGRDVALRPDMTSSVARLYVNSFQTAPKPIKWYYIANMFRYEEPQSGRYRE 118
K++Y F+D+ G + LRP+ T+ R + + + + +Y+ MFR+E PQ GRYR+
Sbjct: 65 KEMYTFEDRNGDSLTLRPEGTAGCVRSGIENGLLYNQEQRLWYMGPMFRHERPQKGRYRQ 124
Query: 119 FWQAGVELIGSDKIEADAEVIALFVDSYLSTGLKDFTVNIGDRVLLDEFAKMLGVKD-DI 177
F Q GVE+ G D + DAE+I + + G+ R+ L+ + +
Sbjct: 125 FHQCGVEVFGLDGPDVDAELIMMTARLWRELGIAQHV-----RLELNSIGSLEARANYRT 179
Query: 178 GLMRIIDKKDKLSQEEFLKALGEFGLDENGIEKVLNLIEIKGKPD--DVLPLAEEL--FT 233
L+ +++ + E+ + + L +++ K PD +L A +L +
Sbjct: 180 ALIDYLEQYQNVLDEDCKRRM---------YTNPLRVLDSKN-PDVQAILGDAPQLSDYL 229
Query: 234 SERAKEEISRLYNLVDILSW-YEVDEWIQIDLGIARGFDYYTSIVFEAIVPNDLGIGSIG 292
+K+ + L L+D Y V++ + RG DYY VFE I + G++
Sbjct: 230 DAESKQHFAGLCELLDAAGIEYTVNQ------RLVRGLDYYNRTVFEWITESLGSQGTVC 283
Query: 293 GGGRYDNLIEVFGGKPTPATGFAIGIERLIPILEWKGLLPELKAGPDVFVIPVGDSRDVA 352
GGGRYD L+E GGKPTPA GFA+G+ERL+ ++E G +++ DV+++ G+ +A
Sbjct: 284 GGGRYDGLVEQLGGKPTPAVGFAMGLERLVLMMETLG-NTDVRRSVDVYMVTAGEGTMMA 342
Query: 353 -TAIVTRLRK--AGIRSDIELSGRKLRKALDYANRIGVRLSIIVGKRDLERGVVTIRDLE 409
+ +LR+ G+R G +K A+++G +++++G+ ++ V ++DL
Sbjct: 343 GMKLAEQLREQVPGLRVMTHFGGGNFKKQFKRADKVGAAIALVLGEDEVAAQTVVVKDLA 402
Query: 410 SGNQ 413
G Q
Sbjct: 403 GGEQ 406
>pir||G81871 probable histidine--tRNA ligase (EC 6.1.1.21) NMA1065 [imported] -
Neisseria meningitidis (group A strain Z2491)
>gi|7379761|emb|CAB84329.1| (AL162755) putative
histidyl-tRNA synthetase [Neisseria meningitidis Z2491]
Length = 431
Score = 173 bits (433), Expect = 5e-42
Identities = 135/428 (31%), Positives = 213/428 (49%), Gaps = 38/428 (8%)
Query: 2 IERVKGTRDFLPEE-----MVKRRW-VFEK-IREVFETYGFKEVLTPVMEYTKLFQLRSG 54
I+ VKG D LP E + W FE + TYG++++ TP++E T LF G
Sbjct: 5 IQSVKGMNDLLPVEQKDFKLTAAFWQAFEDTVGRWTRTYGYQQIRTPIVEQTGLFVRSIG 64
Query: 55 EE---VVKQLYAFKDKGGR-DVALRPDMTSSVARLYVNSFQTAPKPIKWYYIANMFRYEE 110
EE V K++Y F D ++LRP+ T+S R V P K +Y+ MFR E
Sbjct: 65 EETDVVGKEMYTFSDSNDSLSLSLRPEGTASCLRAVVEHNFLYNSPQKLWYMGPMFRRER 124
Query: 111 PQSGRYREFWQAGVELIGSDKIEADAEVIALFVDSYLSTGLKDF-TVNIGDRVLLDEFAK 169
PQ GRYR+F Q G+E +G + + DAE+IA+ D + G++++ T+ I +E A
Sbjct: 125 PQKGRYRQFHQVGIEALGFEGPDIDAEIIAMSADLWEKLGIREYLTLEINSLGNREERAA 184
Query: 170 MLGVKDDIGLMRIIDKKDKLSQEEFLKALGEFGLDENGIEKVLNLIEIKGKPD--DVLPL 227
+ L R DK D+ S+ LK L +++ K PD ++
Sbjct: 185 HRAALVEY-LTRYEDKLDEDSKRR-LKT------------NPLRVLDTKN-PDLQEICNA 229
Query: 228 AEEL--FTSERAKEEISRLYNLVDILSWYEVDEWIQIDLGIARGFDYYTSIVFEAIVPND 285
A L + E ++ +R ++D L ++ + + RG DYY VFE
Sbjct: 230 APRLVDYLGEASQNHYARFKAMLDGLGIQYIE-----NPRLVRGLDYYNQTVFEWTTDKL 284
Query: 286 LGIGSIGGGGRYDNLIEVFGGKPTPATGFAIGIERLIPILEWKGLLPELKAGPDVFVIPV 345
++ GGGRYD LIE GGKP P+ GFA+GIERL+ ++ G L E+ A PDV+ +
Sbjct: 285 GAQATVCGGGRYDGLIEELGGKPAPSIGFAMGIERLLLLVSEYGSL-EVNAAPDVYAMHQ 343
Query: 346 GDSRDVATAIVTRLRKAGIRSDIELSG-RKLRKALDYANRIGVRLSIIVGKRDLERGVVT 404
G+ D+ + +A + ++ SG + L+ + A+ G R ++IV + +L G VT
Sbjct: 344 GEGADLQVMKYAQALRAQGFNVMQHSGYQSLKAQMKKADNSGARFALIVAQDELANGTVT 403
Query: 405 IRDLESGN 412
++D+ +
Sbjct: 404 LKDMNGAH 411
>sp|O34459|HISZ_BACSU ATP PHOSPHORIBOSYLTRANSFERASE REGULATORY SUBUNIT
>gi|7437821|pir||H69641 histidine--tRNA ligase (EC
6.1.1.21) hisZ - Bacillus subtilis
>gi|2618864|gb|AAC67293.1| (AF017113) histidyl-tRNA
synthetase [Bacillus subtilis]
>gi|2636006|emb|CAB15498.1| (Z99121) histidyl-tRNA
synthetase [Bacillus subtilis]
Length = 391
Score = 172 bits (432), Expect = 6e-42
Identities = 117/330 (35%), Positives = 180/330 (54%), Gaps = 10/330 (3%)
Query: 1 MIERVKGTRDFLPEEMVKRRWVFEKIREVFETYGFKEVLTPVMEYTKLFQLRSGEEVVKQ 60
M E+ G RD LP ++ V + ++ + +G++ + TP +E+ ++S E +Q
Sbjct: 3 MFEKPHGMRDTLPGLYETKKKVRRSLTDLIDKWGYQFMETPTLEFYDTVGVQSAIEE-QQ 61
Query: 61 LYAFKDKGGRDVALRPDMTSSVARLYVNSFQTAPKPIKWYYIANMFRYEEPQSGRYREFW 120
L+ D+ G+ + LRPDMT +AR+ + P++ Y AN+FR +E + GR EF
Sbjct: 62 LFKLLDQDGKTLVLRPDMTGPIARVAASKLLKHGHPLRVGYAANVFRAQEREGGRPAEFE 121
Query: 121 QAGVELIGSDKIEADAEVIALFVDSYLSTGLKDFTVNIGDRVLLDE-FAKMLG-VKDDIG 178
Q GVELIG ADAEVIAL V + + GL F + IG + D F ++LG V+
Sbjct: 122 QVGVELIGDGTTSADAEVIALVVGALKNAGLASFKIAIGHAGIADALFVEVLGNVERADV 181
Query: 179 LMRIIDKKDKLSQEEFLKALGEFGLDENGIEKVLNLIEIKGKPDDVLPLAEELFTSERAK 238
L R + +K+ + E +K+L +D++ ++L L+E++G +V AEE+ S + K
Sbjct: 182 LRRFLYEKNYVGYREHVKSLPLSSIDKS---RLLELLELRG-GIEVCGRAEEIVDSAQGK 237
Query: 239 EEISRLYNLVDILSWYEVDEWIQIDLGIARGFDYYTSIVFEAIVPNDLGIGSIGGGGRYD 298
+ L L DIL Y E +++DL + YYT I+FE N +G IG GGRY+
Sbjct: 238 SVVDELKALWDILEDYGCTENVRLDLNMVSHMSYYTGILFEVYAEN-VGF-VIGSGGRYN 295
Query: 299 NLIEVFGGKPTPATGFAIGIERLIPILEWK 328
L+ F P PATGF + I+RLI L K
Sbjct: 296 KLLGHF-DSPAPATGFGLRIDRLIEALHMK 324
>sp|P07178|SYH_MESAU HISTIDYL-TRNA SYNTHETASE (HISTIDINE--TRNA LIGASE) (HISRS)
>gi|68566|pir||SYHYHT histidine--tRNA ligase (EC
6.1.1.21) - Chinese hamster >gi|49632|emb|CAA28957.1|
(X05346) histidyl-tRNA synthetase (AA 1-508)
[Mesocricetus auratus]
Length = 508
Score = 171 bits (430), Expect = 1e-41
Identities = 134/454 (29%), Positives = 230/454 (50%), Gaps = 28/454 (6%)
Query: 1 MIERVKGTRDFLPEEMVKRRWVFEKIREVFETYGFKEVLTPVMEYTKLFQLRSGEEVVKQ 60
+++ KGTRD+ P +M R VF+ I F+ +G + + TPV E + + G++ K
Sbjct: 55 VLKTPKGTRDYSPRQMAVREKVFDVIICCFKRHGAEVIDTPVFELKETLMGKYGQDC-KL 113
Query: 61 LYAFKDKGGRDVALRPDMTSSVAR-LYVNSFQTAPKPIKWYYIANMFRYEEPQS--GRYR 117
+Y KD+GG ++LR D+T R L +N+ IK Y+IA ++R + P GRY
Sbjct: 114 IYDLKDQGGELLSLRYDLTVPFGRYLAMNNLTN----IKRYHIAKVYRRDNPAMTRGRYL 169
Query: 118 EFWQAGVELIGS-DKIEADAEVIALFVDSYLSTGLKDFTVNIGDRVLLDEFAKMLGVKDD 176
++ G D + DAE + + + S + F V + DR +LD + GV D
Sbjct: 170 NSITVDFDIAGQFDPMIPDAECLKIMCEILSSLQIGKFLVKVNDRRILDGMFAVCGVPDS 229
Query: 177 I--GLMRIIDKKDKLSQEEFLKAL-GEFGLDENGIEKVLNLIEIKGKPDDVLPLAEE--L 231
+ +DK DK+S EE + GE GL +++ + ++ G+ V L ++ L
Sbjct: 230 KFRTICSSVDKLDKVSWEEVKNEMVGEKGLAPEVADRIGDYVQQHGEVCLVEQLLQDPKL 289
Query: 232 FTSERAKEEISRLYNLVDILSWYEVDEWIQIDLGIARGFDYYTSIVFEAIV---PNDLG- 287
+++A E + L L + L+ + +D+ I DL +ARG DYYT +++ A++ P G
Sbjct: 290 SQNKQAVEGLGDLKLLFEYLTLFGIDDKISFDLSLARGLDYYTGVIYVAVLLQMPTGAGE 349
Query: 288 ---IGSIGGGGRYDNLIEVFG--GKPTPATGFAIGIERLIPILEWK-GLLPELKAGPDVF 341
G G RYD L+ +F G+ P G +IG+ER+ I+E + L E +
Sbjct: 350 EPWCGQCGCWRRYDGLVGMFDPKGRKVPCVGLSIGVERIFSIVEQRLEALEEKVRTTETQ 409
Query: 342 VIPVGDSRDVA---TAIVTRLRKAGIRSDIELSGR-KLRKALDYANRIGVRLSIIVGKRD 397
V+ + +A T +L AGI++++ KL L Y G+ L I+G+++
Sbjct: 410 VLVASAQKKLAGGETKACLQLWDAGIKAELLYKKNPKLLNQLQYCEETGIPLVAIIGEQE 469
Query: 398 LERGVVTIRDLESGNQVEVPVDNVVTKVRELLNQ 431
L+ GV+ +R + S +V+V +++V ++R NQ
Sbjct: 470 LKDGVIKLRSVASREEVDVRREDLVEEIRRRTNQ 503
>pir||E83171 histidyl-tRNA synthetase PA3802 [imported] - Pseudomonas aeruginosa
(strain PAO1) >gi|9949975|gb|AAG07189.1|AE004798_12
(AE004798) histidyl-tRNA synthetase [Pseudomonas
aeruginosa]
Length = 429
Score = 171 bits (429), Expect = 1e-41
Identities = 126/431 (29%), Positives = 206/431 (47%), Gaps = 32/431 (7%)
Query: 2 IERVKGTRDFLPEEMVKRRWVFEKIREVFETYGFKEVLTPVMEYTKLFQLRSGEE---VV 58
++ ++G D LPE+ R++ + + YG+ E+ P++E+T+LF GE V
Sbjct: 5 LQAIRGMNDILPEQTPAWRYLERTFAGLLDGYGYSEIRLPILEFTELFARGIGEGTDVVD 64
Query: 59 KQLYAFKDKGGRDVALRPDMTSSVARLYVNSFQTAPKPI-KWYYIANMFRYEEPQSGRYR 117
K++Y F D+ G + +RP+ T+ R + + + K +Y MFRYE+PQ GRYR
Sbjct: 65 KEMYTFLDRNGESLTMRPEGTAGCVRAVLEHGLSGGGQVQKLWYTGPMFRYEKPQKGRYR 124
Query: 118 EFWQAGVELIGSDKIEADAEVIALFVDSYLSTGLKDFTVNIGDRVLLDEFAKMLGVKDDI 177
+F Q GVE+ + DAE+I L + G+ D V + L A+
Sbjct: 125 QFHQIGVEVFNLPGPDIDAELIILTWRLWQKLGMAD-AVTLQLNTLGSSEARA------- 176
Query: 178 GLMRIIDKKDKLSQEEFLKALGEFGLDENGIEKV----LNLIEIKGKPDDVLPLAEELFT 233
R + QE F + LDE+ ++ L +++ K + L +
Sbjct: 177 ---RYREALVAYLQERFEQ------LDEDSQRRMTTNPLRILDSKVESTQALLVGAPTLH 227
Query: 234 SERAKEEISRLYNLVDILSWYEVDEWIQIDLGIARGFDYYTSIVFEAIVPNDLGIGSIGG 293
+E I+ L L V +I+ + RG DYY FE + G++ G
Sbjct: 228 DYLDEESIAHFEGLKARLD--AVGLRYEINQKLVRGLDYYCRTAFEWVTDKLGAQGTVCG 285
Query: 294 GGRYDNLIEVFGGKPTPATGFAIGIERLIPILEWKGLLP-ELKAGPDVFVIPVGDSRDVA 352
GGRYD L+ FGGKPTP GFA+G+ERL+ +LE G++P EL D++V G+ ++A
Sbjct: 286 GGRYDGLVSQFGGKPTPGVGFAMGVERLVLLLETLGVIPAELNRPADLYVCAFGEPAELA 345
Query: 353 T-AIVTRLRKA--GIRSDIELSGRKLRKALDYANRIGVRLSIIVGKRDLERGVVTIRDL- 408
+ +LR A GIR + + A++ G R ++I+G+ ++ VV + L
Sbjct: 346 ALTLAEQLRSAIPGIRLLVNAGAGSFKSQFKKADKSGARFALILGEDEVANRVVGFKPLR 405
Query: 409 ESGNQVEVPVD 419
+ G Q + D
Sbjct: 406 DEGEQQSIAWD 416
>sp|P57375|SYH_BUCAI HISTIDYL-TRNA SYNTHETASE (HISTIDINE--TRNA LIGASE) (HISRS)
>gi|10038963|dbj|BAB12998.1| (AP001118) histidyl-tRNA
synthetase [Buchnera sp. APS]
Length = 423
Score = 171 bits (428), Expect = 2e-41
Identities = 127/442 (28%), Positives = 229/442 (51%), Gaps = 40/442 (9%)
Query: 2 IERVKGTRDFLPEEMVKRRWVFEKIREVFETYGFKEVLTPVMEYTKLFQLRSG---EEVV 58
I+ ++G D+ P+++ ++ +EV +Y + E+ P++E T++F+ G + V
Sbjct: 5 IKSIRGMYDYFPKDLKIWNYIEIIFKEVLNSYCYLEIRLPILEKTEIFKRAIGNVTDVVE 64
Query: 59 KQLYAFKDKGGRDVALRPDMTSSVARLYVNSFQTAPKPIKWYYIANMFRYEEPQSGRYRE 118
K++Y+F D+ G ++ LRP+ T R + + K K++Y+ MFRYE PQ GRYR+
Sbjct: 65 KEMYSFNDRKGNNLTLRPEGTVGCVRAIIQN-NLLQKSNKFWYLGPMFRYERPQKGRYRQ 123
Query: 119 FWQAGVELIGSDKIEADAEVIALFVDSYLSTGLKDFTVNIGDRVLLDEFAKM----LGVK 174
F+Q G E+ G D + D E+I L T + R+ +D F + +G K
Sbjct: 124 FYQLGAEVFGLDTEDIDLEIIIL-------------TNRLWKRIGIDSFITLEVNSIGSK 170
Query: 175 DDIGLMRIIDKKDKLSQEEFLKALGEFGLDENGIEKVLN--LIEIKGKPDDVLPLAEE-- 230
D R+ KK+ ++ FLK E+ LDE+ ++ L + K D+ L +E
Sbjct: 171 ID----RVQYKKELVN---FLKKR-EYLLDEDCKRRLYTNPLRILDSKNQDIQNLLKEAP 222
Query: 231 LFTSERAKEEISRLYNLVDILSWYEVDEWIQIDLGIARGFDYYTSIVFEAIVPNDLGI-G 289
L + + E + NL ++++ + + + + + RG DYY S VFE N LG
Sbjct: 223 LLSEYISFSENNHFKNLCNMMNHHGIK--YKCNPHLVRGLDYYNSTVFEW-KSNKLGAQN 279
Query: 290 SIGGGGRYDNLIEVFGGKPTPATGFAIGIERLIPILEWKGLLPELKAGPDVFVIPVGDSR 349
+I GGRYD+L++ GG+ TPA GFAIGIERL+ +++ + E+ +V++I +GD+
Sbjct: 280 TICAGGRYDSLVQEMGGRKTPAIGFAIGIERLVLLVKSLKIFSEVIEESNVYIIFIGDNN 339
Query: 350 DV-ATAIVTRLRK--AGIRSDIELSGRKLRKALDYANRIGVRLSIIVGKRDLERGVVTIR 406
A + +R +R I + L K + A R+ I++G ++++G ++
Sbjct: 340 KCHAINLSEEIRDLYPKLRIFINFLHQNLTKKIKNAISSLARIIILIGDNEIKKGFFLVK 399
Query: 407 DLESGNQVEVPVDNVVTKVREL 428
DL+ + + ++ K++E+
Sbjct: 400 DLKEKKEYHLLKKELILKIQEI 421
>pir||A81150 histidyl-tRNA synthetase NMB0854 [imported] - Neisseria
meningitidis (group B strain MD58)
>gi|7226090|gb|AAF41265.1| (AE002438) histidyl-tRNA
synthetase [Neisseria meningitidis MC58]
Length = 431
Score = 168 bits (422), Expect = 9e-41
Identities = 136/447 (30%), Positives = 220/447 (48%), Gaps = 39/447 (8%)
Query: 2 IERVKGTRDFLPEE-----MVKRRW-VFEK-IREVFETYGFKEVLTPVMEYTKLFQLRSG 54
I+ VKG D LP + + W FE + YG++++ TP++E T LF G
Sbjct: 5 IQSVKGMNDLLPVKQKDFKLTAAFWQAFEDTVGRWTRAYGYQQIRTPIVEQTGLFVRSIG 64
Query: 55 EE---VVKQLYAFKDKGGR-DVALRPDMTSSVARLYVNSFQTAPKPIKWYYIANMFRYEE 110
EE V K++Y F D ++LRP+ T+S R V P K +Y+ MFR E
Sbjct: 65 EETDVVGKEMYTFSDSNDSLSLSLRPEGTASCLRAVVEHNLLYNSPQKLWYMGPMFRRER 124
Query: 111 PQSGRYREFWQAGVELIGSDKIEADAEVIALFVDSYLSTGLKDF-TVNIGDRVLLDEFAK 169
PQ GRYR+F Q G+E +G + + DAE+IA+ D + G++++ T+ I +E A
Sbjct: 125 PQKGRYRQFHQVGIEALGFEGPDIDAEIIAMSADLWEKLGIREYLTLEINSLGNREERAA 184
Query: 170 MLGVKDDIGLMRIIDKKDKLSQEEFLKALGEFGLDENGIEKVLNLIEIKGKPD--DVLPL 227
+ L R DK D+ S+ LK L +++ K PD ++
Sbjct: 185 HRAALVEY-LTRYEDKLDEDSKRR-LKT------------NPLRVLDTK-NPDLQEICNA 229
Query: 228 AEEL--FTSERAKEEISRLYNLVDILSWYEVDEWIQIDLGIARGFDYYTSIVFEAIVPND 285
A L + E ++ R ++D L ++ + + RG DYY VFE
Sbjct: 230 APRLVDYLGEDSQNHYVRFKAMLDGLGIQYIE-----NPRLVRGLDYYNQTVFEWTTDKL 284
Query: 286 LGIGSIGGGGRYDNLIEVFGGKPTPATGFAIGIERLIPILEWKGLLPELKAGPDVFVIPV 345
++ GGGRYD LIE GGKP P+ GFA+GIERL+ ++ G L E+ A PDV+ +
Sbjct: 285 GAQATVCGGGRYDGLIEELGGKPAPSIGFAMGIERLLLLVSEYGSL-EVNAAPDVYAMHQ 343
Query: 346 GDSRDVATAIVTRLRKAGIRSDIELSG-RKLRKALDYANRIGVRLSIIVGKRDLERGVVT 404
G+ D+ + +A + ++ SG + L+ + A+ G R ++IV + +L G VT
Sbjct: 344 GEGADLQVMKYAQALRAQGFNVMQHSGYQSLKAQMKKADNSGARFALIVAQDELANGTVT 403
Query: 405 IRDLESGN-QVEVPVDNVVTKVRELLN 430
++D+ + Q V +++ +++ N
Sbjct: 404 LKDMNGAHGQQTVAAEDLTPTLQQWKN 430
>sp|Q9ZDL9|SYH_RICPR HISTIDYL-TRNA SYNTHETASE (HISTIDINE--TRNA LIGASE) (HISRS)
>gi|7437818|pir||G71686 histidine--tRNA ligase (EC
6.1.1.21) (hisS) RP308 - Rickettsia prowazekii
>gi|3860869|emb|CAA14769.1| (AJ235271) HISTIDYL-TRNA
SYNTHETASE (hisS) [Rickettsia prowazekii]
Length = 416
Score = 168 bits (420), Expect = 2e-40
Identities = 133/441 (30%), Positives = 215/441 (48%), Gaps = 43/441 (9%)
Query: 2 IERVKGTRDFLPEEMVKRRWVFEKIREVFETYGFKEVLTPVMEYTKLFQLRSGEE---VV 58
++ ++G +D LP + ++ K R+V YG+K++ TP++EYTK+F GE +
Sbjct: 8 LQPLRGMKDLLPNDYQIHNYIINKARDVGALYGYKQMSTPILEYTKVFNRSMGESSDVMS 67
Query: 59 KQLYAFKDKGGRDVALRPDMTSSVARLYVNSFQTAPKPIKWYYIANMFRYEEPQSGRYRE 118
K++Y+F DK VALRP+ TS + R ++++ P+K++ +FRY+ PQ+GR R+
Sbjct: 68 KEIYSFVDKSNNAVALRPEFTSGIIRSFISNGLQHKLPLKFFSTGPVFRYDRPQAGRQRQ 127
Query: 119 FWQAGVELIGSDKIEADAEVIALFVDSYLSTGLKDFTV----NIG---DRVLLDEFAKML 171
F Q E +G+ DAE + L VD + +++ T ++G R++ + K++
Sbjct: 128 FHQLNYEYLGAKGAITDAETVKLAVDILKALEIEEDTTLELNSLGCHESRIVYQQ--KLV 185
Query: 172 GVKDDIGLMRIIDKKDKLSQEEFLKALGEFGLDENGIEKVLNLIEIKGKPDDVLPLAEEL 231
+D KD+LS E L+ L++N + + + EI K P+ E
Sbjct: 186 EYLNDF--------KDQLSGESRLR------LNKNPMRILDSKSEIDQKIIAHAPILSEY 231
Query: 232 FTSERAKEEISRLYNLVDILSWYEVDEWIQIDLGIARGFDYYTSIVFEAIVPNDLGIGSI 291
T+E +K+ L +DIL ++ + RG DYY VFE +I
Sbjct: 232 HTNE-SKKYFDELQKYLDILGIK-----YSVNPRLVRGLDYYCHTVFEFTTKKLGSQSTI 285
Query: 292 GGGGRYDNLIEVFGGKPTPATGFAIGIERLIPILEWKGLLPELKAGPDVFVIPVGDSR-D 350
GGRYD L + G A GFA GIER+ + E+K + VFV+P+G +
Sbjct: 286 LAGGRYDMLSRIMGNYDVHAIGFAAGIERIALMREYK-----ISVIKPVFVLPIGKNNIC 340
Query: 351 VATAIVTRLRKAGIRSDIELSGRKLRKALDYANRIGVRLSIIVGKRDLERGVVTIRDLES 410
A IV +LR I S I+ G K+ K + + I +G + + +DL+
Sbjct: 341 YALDIVDKLRLQNIVSIIDPIG-KIAKRIQRVLNEDAKFIIFIGDEEKMNNNLKFKDLK- 398
Query: 411 GNQVEVPVDNVVTKVRELLNQ 431
NQ E +D KV ELL Q
Sbjct: 399 -NQKEYIID--FEKVLELLKQ 416
>sp|P43823|SYH_HAEIN HISTIDYL-TRNA SYNTHETASE (HISTIDINE--TRNA LIGASE) (HISRS)
>gi|1074203|pir||I64063 histidine--tRNA ligase (EC
6.1.1.21) - Haemophilus influenzae (strain Rd KW20)
>gi|1573338|gb|AAC22027.1| (U32721) histidyl-tRNA
synthetase (hisS) [Haemophilus influenzae Rd]
Length = 423
Score = 165 bits (414), Expect = 8e-40
Identities = 120/433 (27%), Positives = 210/433 (47%), Gaps = 33/433 (7%)
Query: 2 IERVKGTRDFLPEEMVKRRWVFEKIREVFETYGFKEVLTPVMEYTKLFQLRSGEE---VV 58
I+ ++G D P E +W+ ++R V +YG+ EV P++E T LF GE V
Sbjct: 5 IQAIRGMNDCAPTESPLWQWIEAQVRNVLNSYGYSEVRMPIVESTPLFARAIGEVTDVVS 64
Query: 59 KQLYAFKDKGGRDVALRPDMTSSVARLYVNSFQTAPKPIKWYYIANMFRYEEPQSGRYRE 118
K++Y F D + LRP+ T+ R + + +YI MFR+E PQ GRYR+
Sbjct: 65 KEMYTFWDND-EQLTLRPEGTAGCVRAAIEHGWIYNNEQRLWYIGPMFRHERPQKGRYRQ 123
Query: 119 FWQAGVELIGSDKIEADAEVIALFVDSYLSTGL-KDFTVNIGDRVLLDEFAKMLGVKDDI 177
F Q GVE+ G E DAE+I L + + G+ + T+ + L+ A +
Sbjct: 124 FHQVGVEVFGIANPEIDAELIMLTYRLWKALGIDQHVTLQLNSIGSLEARANYRSAL--V 181
Query: 178 GLMRIIDKKDKLSQEEFLKALGEFGLDENGIEKVLNLIEIKGKP-DDVLPLAEEL--FTS 234
G + + +D +S EE E + L +++ K VL A +L +
Sbjct: 182 GFLE--NHQDLMSDEE----------KERLVRNPLRILDTKNPELQKVLDNAPKLLDYLD 229
Query: 235 ERAKEEISRLYNLVDILS-WYEVDEWIQIDLGIARGFDYYTSIVFEAIVPNDLGIGSIGG 293
+ ++ +L +L+D + YE++ + RG DYY VFE + G++ G
Sbjct: 230 DESRTHFEQLCSLLDAVGIQYEINP------KLVRGLDYYNKTVFEWVTSALGAQGTVCG 283
Query: 294 GGRYDNLIEVFGGKPTPATGFAIGIERLIPILEWKGLLPELKAGPDVFVIPVGDSRDVAT 353
GGRYD L+E GG TP+ GFA+G+ERL+ +++ K+ D++V+ G+ +A
Sbjct: 284 GGRYDGLVEQLGGHATPSIGFAMGLERLVLLVQEVNPNVPAKSAVDIYVVYQGEGATLAA 343
Query: 354 ---AIVTRLRKAGIRSDIELSGRKLRKALDYANRIGVRLSIIVGKRDLERGVVTIRDLES 410
A R + + + S +K A++ G L++++G+ +++ V ++ L+
Sbjct: 344 FELAEKVRSELPHLNTMLHCSSGNFKKQFKRADKSGATLALVIGESEVQNKQVVVKHLQG 403
Query: 411 G-NQVEVPVDNVV 422
G +Q + + N++
Sbjct: 404 GTDQQTLDLVNII 416
>sp|Q9Z7P1|SYH_CHLPN HISTIDYL-TRNA SYNTHETASE (HISTIDINE--TRNA LIGASE) (HISRS)
>gi|7437819|pir||H72052 histidine--tRNA ligase (EC
6.1.1.21) - Chlamydophila pneumoniae (strains CWL029 and
AR39) >gi|4376962|gb|AAD18802.1| (AE001648) Histidyl
tRNA Synthetase [Chlamydophila pneumoniae CWL029]
>gi|7189020|gb|AAF37970.1| (AE002172) histidyl-tRNA
synthetase [Chlamydophila pneumoniae AR39]
Length = 430
Score = 165 bits (413), Expect = 1e-39
Identities = 121/394 (30%), Positives = 196/394 (49%), Gaps = 28/394 (7%)
Query: 22 VFEKIREVFETYGFKEVLTPVMEYTKLFQLRSGEE---VVKQLYAFKDKGGRDVALRPDM 78
V + I V YGF E+ TP+ E +++F L GEE V K++Y+F D+ GR + LRP+
Sbjct: 32 VEKAIHTVCMLYGFCEIRTPIFEKSEVF-LHVGEESDVVKKEVYSFLDRKGRSMTLRPEG 90
Query: 79 TSSVARLYVNSFQTAPKPIKWYYIANMFRYEEPQSGRYREFWQAGVELIGSDKIEADAEV 138
T++V R ++ + K+YYI MFRYE Q+GRYR+ Q GVE IG DAEV
Sbjct: 91 TAAVVRSFLEHGASHRSDNKFYYILPMFRYERQQAGRYRQHHQFGVEAIGVRHPLRDAEV 150
Query: 139 IALFVDSYLSTGLKDFTVNIGDRVLLDEFAKMLGVKDDIGLMRIIDKKDKLSQEEFLKAL 198
+AL D Y GL+ + + + +G + DK+ + +++
Sbjct: 151 LALLWDFYSRVGLQHMQIQL----------------NFLGGSETRFRYDKVLRAYLKESM 194
Query: 199 GEFGL--DENGIEKVLNLIEIKGKPDDVLPLAEELFTSERAKEEISRLYNLVDILSWYEV 256
GE + VL +++ K D + + E++ ++D L E+
Sbjct: 195 GELSALSQQRFSTNVLRILDSKEPEDQEIIRQAPPILDYVSDEDLKYFNEILDALRVLEI 254
Query: 257 DEWIQIDLGIARGFDYYTSIVFEAIVPNDLGIGSIGGGGRYDNLIEVFGGKPTPATGFAI 316
I+ + RG DYY+ +VFEA ++GGGGRYD LI FGG PA GF +
Sbjct: 255 P--YAINPRLVRGLDYYSDLVFEATTTFQEVSYALGGGGRYDGLISAFGGASLPACGFGV 312
Query: 317 GIERLI-PILEWKGLLPELKAGPDVFVIPV-GDSRDVATAIVTRLRKAGIRSDIELSGRK 374
G+ER I +L K + P+ + +IP+ D+ LR+ GI ++++ S +K
Sbjct: 313 GLERAIQTLLAQKRIEPQFP--HKLRLIPMEPDADQFCLEWSQHLRRLGIPTEVDWSHKK 370
Query: 375 LRKALDYANRIGVRLSIIVGKRDLERGVVTIRDL 408
++ AL A+ V ++G+R+L + I+++
Sbjct: 371 VKGALKAASTEQVSFVCLIGERELISQQLVIKNM 404
>sp|P47281|SYH_MYCGE HISTIDYL-TRNA SYNTHETASE (HISTIDINE--TRNA LIGASE) (HISRS)
>gi|1361544|pir||H64203 histidine--tRNA ligase (EC
6.1.1.21) - Mycoplasma genitalium
>gi|3844645|gb|AAC71251.1| (U39683) histidyl-tRNA
synthetase [Mycoplasma genitalium]
Length = 414
Score = 164 bits (411), Expect = 2e-39
Identities = 129/423 (30%), Positives = 205/423 (47%), Gaps = 37/423 (8%)
Query: 2 IERVKGTRDFLPEEMVKRRWVFEKIREVFETYGFKEVLTPVMEYTKLFQLRSGEE--VVK 59
+++ +G +D+ +E+V W+ +KIR + +GF EV TP+ E +LFQ + V K
Sbjct: 4 LQKPRGVKDWFGDELVYFNWIVKKIRSLAFNWGFSEVKTPLFENAQLFQRSNANADIVQK 63
Query: 60 QLYAFKDKGGRDVALRPDMTSSVARLYVNS--FQTAPKPIKWYYIANMFRYEEPQSGRYR 117
+LY F DK R++ALRP+ T+ + RL + Q A P+K + I +M+RYE PQ+ R+R
Sbjct: 64 ELYQFFDKSQRELALRPEATTPIVRLACENKLMQEANFPLKLFCIGSMYRYERPQNNRFR 123
Query: 118 EFWQAGVELIGSDKIEADAEVIALFVDSYLST-GLKDFTVNIGDRVLLDEFAKM-LGVKD 175
E WQ E+ G + + + LF +S L G+ + + I + + +K +KD
Sbjct: 124 EHWQFSCEVFGFSNLFIFLDTL-LFANSLLEALGITGYVLKINNLANFETLSKWNKALKD 182
Query: 176 DIGLMRIIDKKDKLSQEEFLKALGEFGLDENGIEKVLNLIEIKGKPDDVLPLA----EEL 231
+ ++ + +LSQ+ K + ++ I++ + ++ K D L + EL
Sbjct: 183 YLTPYKL--ELTELSQKRLEK--NPLRILDDKIDQKKSFVKNAPKITDFLDASAKQDSEL 238
Query: 232 FTSERAKEEISRLYNLVDILSWYEVDEWIQIDLGIARGFDYYTSIVFEAIVPNDLGIGSI 291
++ K IS EW + RG DYYT VFE + D +I
Sbjct: 239 LKTQLKKHNISF--------------EWTD---NLVRGLDYYTGFVFEYVKNQD----TI 277
Query: 292 GGGGRYDNLIEVFGGKPTPATGFAIGIERLIPILEWKGLLPELKAGP-DVFVIPVGDSRD 350
GG YDNL+E PTPA GFA GIERLI LE L P + VI + +
Sbjct: 278 LAGGVYDNLVEELSSNPTPALGFACGIERLINCLEIDKKAFILNTKPKQMLVICLFEEAL 337
Query: 351 VATAIVTRLRKAGIRSDIELSGRKLRKALDYANRIGVRLSIIVGKRDLERGVVTIRDLES 410
+ +L + + I K+ + ANR+G IVGK D ++ +TI++L S
Sbjct: 338 EELVWLAKLWREYNQVTIYPKVIKVDNGIRLANRLGYTFIGIVGKTDFDKKAITIKNLVS 397
Query: 411 GNQ 413
Q
Sbjct: 398 KQQ 400
>dbj|BAA98870.1| (AP002547) histidyl tRNA synthetase [Chlamydophila pneumoniae J138]
Length = 430
Score = 164 bits (410), Expect = 2e-39
Identities = 120/394 (30%), Positives = 195/394 (49%), Gaps = 28/394 (7%)
Query: 22 VFEKIREVFETYGFKEVLTPVMEYTKLFQLRSGEE---VVKQLYAFKDKGGRDVALRPDM 78
V + I V YGF E+ TP+ E +++F L GEE V K++Y+ D+ GR + LRP+
Sbjct: 32 VEKAIHTVCMLYGFCEIRTPIFEKSEVF-LHVGEESDVVKKEVYSVLDRKGRSMTLRPER 90
Query: 79 TSSVARLYVNSFQTAPKPIKWYYIANMFRYEEPQSGRYREFWQAGVELIGSDKIEADAEV 138
T++V ++ + IK+YYI MFRYE Q+GRYR+ Q GVE IG DAEV
Sbjct: 91 TAAVVSAFLEHGASHRSDIKFYYILPMFRYERQQAGRYRQHHQFGVEAIGVRHPLRDAEV 150
Query: 139 IALFVDSYLSTGLKDFTVNIGDRVLLDEFAKMLGVKDDIGLMRIIDKKDKLSQEEFLKAL 198
+AL D Y GL+ + + + +G + DK+ + +++
Sbjct: 151 LALLWDFYSRVGLQHMQIQL----------------NFLGGSETRFRYDKVLRAYLKESM 194
Query: 199 GEFGL--DENGIEKVLNLIEIKGKPDDVLPLAEELFTSERAKEEISRLYNLVDILSWYEV 256
GE + VL +++ K D + + E++ ++D L E+
Sbjct: 195 GELSALSQQRFSTNVLRILDSKEPEDQEIIRQAPPILDYVSDEDLKYFNEILDALRVLEI 254
Query: 257 DEWIQIDLGIARGFDYYTSIVFEAIVPNDLGIGSIGGGGRYDNLIEVFGGKPTPATGFAI 316
I+ + RG DYY+ +VFEA ++GGGGRYD LI FGG PA GF +
Sbjct: 255 P--YAINPRLVRGLDYYSDLVFEATTTFQEVSYALGGGGRYDGLISAFGGASLPACGFGV 312
Query: 317 GIERLI-PILEWKGLLPELKAGPDVFVIPV-GDSRDVATAIVTRLRKAGIRSDIELSGRK 374
G+ER I +L K + P+ + +IP+ D+ LR+ GI ++++ S +K
Sbjct: 313 GLERAIQTLLAQKRIEPQFP--HKLRLIPMEPDADQFCLEWSQHLRRLGIPTEVDWSHKK 370
Query: 375 LRKALDYANRIGVRLSIIVGKRDLERGVVTIRDL 408
++ AL A+ V ++G+R+L + I+++
Sbjct: 371 VKGALKAASTEQVSFVCLIGERELISQQLVIKNM 404
>pir||F81660 histidyl-tRNA synthetase TC0830 [imported] - Chlamydia muridarum
(strain Nigg) >gi|7190857|gb|AAF39630.1| (AE002349)
histidyl-tRNA synthetase [Chlamydia muridarum]
Length = 428
Score = 164 bits (410), Expect = 2e-39
Identities = 131/400 (32%), Positives = 196/400 (48%), Gaps = 41/400 (10%)
Query: 33 YGFKEVLTPVMEYTKLFQLRSGEE---VVKQLYAFKDKGGRDVALRPDMTSSVARLYVNS 89
YGF E+ TPV E T+ F LR GE V K++Y F DK GR + LRP+ T++V R ++
Sbjct: 43 YGFDEIRTPVFEKTETF-LRVGEHSDIVKKEVYTFLDKKGRSLTLRPEGTAAVVRALLDH 101
Query: 90 FQTAPKPIKWYYIANMFRYEEPQSGRYREFWQAGVELIGSDKIEADAEVIALFVDSYLST 149
K K YYI MFRYE QSGRYR+ Q G+E IG DAEV++L D Y +
Sbjct: 102 SADMRKDNKIYYILPMFRYERQQSGRYRQHHQFGLEAIGVRHPLRDAEVLSLLWDFYAAV 161
Query: 150 GLKDFTVNIG------DRVLLDEFAKMLGVKDDIGLMRIIDKKDKLSQEEFLKALGEFGL 203
GLK + + R DE + KD +DK LSQE F L
Sbjct: 162 GLKHMQIQVNFLGGRKTRARYDEALREFFRKD-------LDKLSTLSQERFHANL----- 209
Query: 204 DENGIEKVLNLIEIKGKPDDVLPLAEELFTSERAKEEISRLYNLVDILSWYEVDEWIQID 263
L +++ K +P+D + + + ++ ++ V + + +I+
Sbjct: 210 --------LRILDSK-EPEDQAFIEQAPSILDYVDDQDLNYFDSV-LAELKVLGIPYKIN 259
Query: 264 LGIARGFDYYTSIVFEAIVPNDLGIGSIGGGGRYDNLIEVFGGKPTPATGFAIGIERLI- 322
+ RG DYYT +VFEA+ ++GGGGRYD L+ GG PA GF +G+ER+I
Sbjct: 260 PRLVRGLDYYTDLVFEAVTVVGDHSYALGGGGRYDELVAQSGGPAMPAFGFGVGLERVIQ 319
Query: 323 PILEWKGLLPELKAGPDVFVIPVGDSRDV-ATAIVTRLRKAGIRSDIELSGRKLRKALDY 381
+LE LP A + +IP+ +S D + LR G+ ++++ + +K + AL
Sbjct: 320 TLLEQGAALP--TAPRRLRLIPMDESADAFCFSWAKHLRHLGVATEVDWAHKKPKTALKD 377
Query: 382 ANRIGVRLSIIVGKRDLERGVVTIRDLE-----SGNQVEV 416
A V VG+++L ++D+ SG Q +V
Sbjct: 378 AADQQVGFVCFVGEQELSTKQFIVKDMSLHQSFSGAQQDV 417
>pir||F75406 histidyl-tRNA synthetase - Deinococcus radiodurans (strain R1)
>gi|6459101|gb|AAF10919.1|AE001981_4 (AE001981)
histidyl-tRNA synthetase [Deinococcus radiodurans]
Length = 427
Score = 158 bits (395), Expect = 1e-37
Identities = 128/447 (28%), Positives = 194/447 (42%), Gaps = 60/447 (13%)
Query: 2 IERVKGTRDFLPEEMVK---------RRWVFEKIREVFETYGFKEVLTPVMEYTKLFQLR 52
I+R KGT D LP K W+ + REV E G + + TP+ E +L +
Sbjct: 3 IQRPKGTNDLLPSGSPKTEAFQRAAAHEWLIAQAREVLERAGAQRIDTPMFEEAELVKRG 62
Query: 53 SG--EEVVKQ----LYAFKDKGGRDVALRPDMTSSVARLYV-NSFQTAPKPIKWYYIANM 105
G ++V++ +Y F D GG LRP+ T+S+ R Y+ N + P P+K + M
Sbjct: 63 VGGSTDIVRKEMFTVYYFGDHGG--YVLRPEGTASIVRAYLENGLKQLPAPLKLWTSGPM 120
Query: 106 FRYEEPQSGRYREFWQAGVELIGSDKIEADAEVIALFVDSYLSTGLKDFTVNIG------ 159
FR E Q GRYR+F Q E++GS DAE IAL V GL+ V +G
Sbjct: 121 FRAERHQKGRYRQFTQVDYEVLGSADALVDAEAIALMVAVVQKLGLRGVRVKLGSIGDPE 180
Query: 160 -----DRVLLDEFAKMLGVKDDIGLMRIIDKKDKLSQEEFLKALGEFGLDENGIEKVLNL 214
+ L D F+ LG D D KD+L + + D+ + ++
Sbjct: 181 DRERYNAYLRDLFSPHLGRLSD-------DSKDRLERNPMRILDSKSASDQELLAEL--- 230
Query: 215 IEIKGKPDDVLPLAEELFTSERAKEEISRLYNLVDILSWYEVDEW---IQIDLGIARGFD 271
V P+ + F E A + ++ + +W +D I RG D
Sbjct: 231 --------SVRPMLD--FLGEGAAADFRQVQAY--------LSDWGVPFDLDPSIVRGLD 272
Query: 272 YYTSIVFEAIVPNDLGIGSIGGGGRYDNLIEVFGGKPTPATGFAIGIERLIPILEWKGLL 331
YY +E ++GGGGRYD L E GG P G+A G+ERL+ LE +G+
Sbjct: 273 YYRRTAWELHYEGIGAKSALGGGGRYDGLSEQLGGGSVPGIGWAFGVERLLLALEQEGIE 332
Query: 332 PELKAGPDVFVIPVGDSRDVATAIVTRLRKAGIRSDIELSGRKLRKALDYANRIGVRLSI 391
GP ++V + + A V +A R++ K A A R G
Sbjct: 333 IPGSGGPQLYVAALDEENVPLAARVALAARASCRAEFAYRAMKPGSAFKDAERRGAVWVG 392
Query: 392 IVGKRDLERGVVTIRDLESGNQVEVPV 418
++G + G +++++L +G Q VPV
Sbjct: 393 LIGSEEAAAGTLSLKNLHTGEQKTVPV 419
>emb|CAA28956.1| (X05345) histidyl-tRNA synthetase (AA 1-508) [Homo sapiens]
Length = 508
Score = 156 bits (391), Expect = 4e-37
Identities = 130/453 (28%), Positives = 221/453 (48%), Gaps = 26/453 (5%)
Query: 1 MIERVKGTRDFLPEEMVKRRWVFEKIREVFETYGFKEVLTPVMEYTKLFQLRSGEEVVKQ 60
+++ KGTRD+ P +M R VF+ I F+ +G + + TPV E + + GE+ K
Sbjct: 55 VLKTPKGTRDYSPRQMAVREKVFDVIIRCFKRHGAEVIDTPVFELKETLMGKYGEDS-KL 113
Query: 61 LYAFKDKGGRDVALRPDMTSSVARLYVNSFQTAPKPIKWYYIANMFRYEEPQ--SGRYRE 118
+Y KD+GG ++LR D+T AR + T IK Y+IA ++R + P GRY
Sbjct: 114 IYDLKDQGGELLSLRYDLTVPFARYLAMNKLTN---IKRYHIAKVYRRDNPAMTGGRYPN 170
Query: 119 FWQAGVELIGS-DKIEADAEVIALFVDSYLSTGLKDFTVNIGDRVLLDEFAKMLGVKDDI 177
++ G D + DAE + + + S + +F V + DR +LD + GV D
Sbjct: 171 SITVDFDIAGQFDPMNPDAESLKIMCEILSSLQIGNFLVKVNDRRILDGMFAVCGVPDSK 230
Query: 178 --GLMRIIDKKDKLSQEEFLKAL-GEFGLDENGIEKVLNLIEIKGKPDDVLPLAEE--LF 232
+ +DK DK+S EE + GE GL +++ + ++ G V L ++ L
Sbjct: 231 FRTICSSVDKLDKVSWEEVKNEMVGEKGLAPEVADRIGDYVQQHGGVSLVEQLVQDPKLS 290
Query: 233 TSERAKEEISRLYNLVDILSWYEVDEWIQIDLGIARGFDYYTSIVFEAIV---PNDLG-- 287
+++A E + L L + L+ + +D+ I DL +ARG DYYT +++EA++ P G
Sbjct: 291 QNKQALEGLGDLKLLFEYLTLFGIDDKISFDLSLARGLDYYTGVIYEAVLLQTPAQEGEE 350
Query: 288 --IGSIGGGGRYDNLIEVFG--GKPTPATGFAIGIERLIPILEWK-GLLPELKAGPDVFV 342
G G RYD L+ +F + G R+ I+E + L E + V
Sbjct: 351 PWCGQCGCWRRYDGLVGMFDPQRRKVAMCGAQHWGGRIFSIVEQRLEALEEKIRTTETQV 410
Query: 343 IPVGDSRDVA---TAIVTRLRKAGIRSD-IELSGRKLRKALDYANRIGVRLSIIVGKRDL 398
+ + +A T RL AGI+++ + KL L Y G+ L I+G+++L
Sbjct: 411 LVASAQKKLARGKTKACLRLWDAGIKAELLYKKNPKLLNQLQYCEEAGIPLVAIIGEQEL 470
Query: 399 ERGVVTIRDLESGNQVEVPVDNVVTKVRELLNQ 431
+ GV+ +R + S +V+V + +V +++ Q
Sbjct: 471 KDGVIKLRSVTSREEVDVRREELVEEIKRRTGQ 503
>sp|Q55267|HISZ_SYNP7 ATP PHOSPHORIBOSYLTRANSFERASE REGULATORY SUBUNIT
>gi|530225|gb|AAA64445.1| (L35476) histidyl tRNA
synthetase [Synechococcus sp.]
Length = 420
Score = 155 bits (387), Expect = 1e-36
Identities = 116/374 (31%), Positives = 194/374 (51%), Gaps = 35/374 (9%)
Query: 7 GTRDFLPEEMVKRRWVFEKIREVFETYGFKEVLTPVMEYTKLFQLRSGEEV----VKQLY 62
GTRD LP+++ ++RW+ ++++VF+ +G++ ++TP +E +L L +G V V Q+
Sbjct: 8 GTRDLLPQDVTQKRWIESRLQQVFQQWGYQRIITPTLE--RLDTLVAGGAVQRSAVIQVQ 65
Query: 63 AFKDKGGRDVALRPDMTSSVARLYVNSFQTAPKPIKWYYIANMFRYE-EPQSGRYREFWQ 121
+ ++ G + LRP++T+S+AR V + P++ YY+AN+FR + + RE +Q
Sbjct: 66 SDEESG---LGLRPELTASIARAAVTRLAGSSLPLRLYYLANVFRPAFQGDRLQQRELFQ 122
Query: 122 AGVELIGSDKIEADAEVIALFVDSYLSTG-----LKDFTVNIGD----RVLLDEFAKMLG 172
AGVEL+G ADAEV+ + D+ G L + + +G+ R LL F K L
Sbjct: 123 AGVELLGVGGTLADAEVLHVLADALAELGFGQPPLGSWHLVVGEASLTRSLLQPFPKDLR 182
Query: 173 VKDDIGLMRIIDKKDKLSQEEFLKALGEFGLDENGIEKVLNLIEIKGKPDDVLPLAEELF 232
K + + I + D+++ E L+ ++ L L +++G+PD V ++L
Sbjct: 183 EK----VRQAIAQFDRVTLESL-------PLESQLRDRALLLHDLRGQPDQVFAKLQQLT 231
Query: 233 TSERAKEEISRLYNLVDIL--SWYEVDEWIQIDLGIARGFDYYTSIVFEAIVPNDLGIGS 290
+ + RL LV++ S D + +DL + R FDYYT IVFE + G
Sbjct: 232 LTPLEQTLRDRLAQLVELYNASAGPQDSPLLLDLSLLRSFDYYTGIVFEVVYETPTGPWV 291
Query: 291 IGGGGRYDNLIEVFGGKPT--PATGFAIGIERLIPILEWKGLLPELKAGPDVFVIPV-GD 347
+ GGRYD L++V+ + P GF+ IE L +L LP D VIPV +
Sbjct: 292 LAQGGRYDRLLDVYDPQAAGQPGIGFSCNIENLQQVLLAANRLPHRPPAIDQLVIPVDSE 351
Query: 348 SRDVATAIVTRLRK 361
+ A A RL++
Sbjct: 352 AYGAALAEAQRLQR 365
>dbj|BAB07303.1| (AP001519) histidyl-tRNA synthetase [Bacillus halodurans]
Length = 397
Score = 155 bits (387), Expect = 1e-36
Identities = 103/331 (31%), Positives = 178/331 (53%), Gaps = 18/331 (5%)
Query: 1 MIERVKGTRDFLPEEMVKRRWVFEKIREVFETYGFKEVLTPVMEYTKLFQLRSGEEVVKQ 60
M E+ G RD LPE ++ + +++ E +G+ + TP +EY + + S + +Q
Sbjct: 6 MFEKPFGMRDTLPEWYKTKKNICDQMTEEINLWGYDMIETPTLEYYETVGVVSAI-LDQQ 64
Query: 61 LYAFKDKGGRDVALRPDMTSSVARLYVNSFQTAPKPIKWYYIANMFRYEEPQSGRYREFW 120
L+ D+ G + LRPDMT+ +ARL +S + P++ Y +N++R ++ + G+ EF
Sbjct: 65 LFKLLDQQGNTLVLRPDMTAPIARLVASSLKDRAYPLRLAYQSNVYRAQQNEGGKPAEFE 124
Query: 121 QAGVELIGSDKIEADAEVIALFVDSYLSTGLKDFTVNIG-----DRVLLDEFAKMLGVKD 175
Q GVELIG AD EVIAL + + GL +F V IG + +L+D ++G +
Sbjct: 125 QLGVELIGDGTASADGEVIALMIAALKRAGLSEFKVAIGHVGYVNALLMD----VVGNEQ 180
Query: 176 DIG-LMRIIDKKDKLSQEEFLKALGEFGLDENGIEKVLNLIEIKGKPDDVLPLAEELFTS 234
L R + +K+ + E +K+L +D++ +++NL+ ++G + A L +
Sbjct: 181 RADRLRRFLYEKNYVGYREHVKSLNLSTIDKS---RLMNLLSLRG-GRAAIEEARGLIQT 236
Query: 235 ERAKEEISRLYNLVDILSWYEVDEWIQIDLGIARGFDYYTSIVFEAIVPNDLGIGSIGGG 294
E+ K ++ + L ++L Y E+++ DL + YYT +VFE N LG+ + G
Sbjct: 237 EKGKTALAEMTKLYEVLESYGASEYVKFDLTLVLHMSYYTGVVFEG-YGNRLGV-PLCSG 294
Query: 295 GRYDNLIEVFGGKPTPATGFAIGIERLIPIL 325
GRYD L+ F +P ATGF + I+ L+ L
Sbjct: 295 GRYDELLSKF-HRPAQATGFGVRIDLLVEAL 324
>sp|O84547|SYH_CHLTR HISTIDYL-TRNA SYNTHETASE (HISTIDINE--TRNA LIGASE) (HISRS)
>gi|7437820|pir||H71500 histidine--tRNA ligase (EC
6.1.1.21) - Chlamydia trachomatis (serotype D, strain
UW3/Cx) >gi|3328982|gb|AAC68145.1| (AE001325) Histidyl
tRNA Synthetase [Chlamydia trachomatis]
Length = 428
Score = 154 bits (385), Expect = 2e-36
Identities = 130/412 (31%), Positives = 198/412 (47%), Gaps = 65/412 (15%)
Query: 33 YGFKEVLTPVMEYTKLFQLRSGEE---VVKQLYAFKDKGGRDVALRPDMTSSVARLYVNS 89
YGF E+ TPV E T+ F LR GE V K++Y F DK R + LRP+ T++V R ++
Sbjct: 43 YGFDEIRTPVFEKTETF-LRVGEYSDIVKKEVYTFLDKKRRSLTLRPEGTAAVVRALLDH 101
Query: 90 FQTAPKPIKWYYIANMFRYEEPQSGRYREFWQAGVELIGSDKIEADAEVIALFVDSYLST 149
K K+YYI MFRYE QSGRYR+ Q G+E IG DAEV++L D Y +
Sbjct: 102 SADMRKDNKFYYILPMFRYERQQSGRYRQHHQFGLEAIGVRHPLRDAEVLSLLWDFYAAV 161
Query: 150 GLKDFTVNIG------DRVLLDEFAKMLGVKDDIGLMRIIDKKDKLSQEEFLKALGEFGL 203
GL+ +++ R DE + KD +D+ LSQE + L
Sbjct: 162 GLQHMQIHVNFLGGQKTRARYDEALREFFRKD-------LDRLSPLSQERYHANL----- 209
Query: 204 DENGIEKVLNLIEIKGKPDDVLPLAEELFTSERAKEEISRLYNLVDI-----LSWYEVDE 258
L +++ K +P+D +E I + +++D LS+++
Sbjct: 210 --------LRILDSK-EPED--------------QEFIEKAPSILDYIDDRDLSYFDAVL 246
Query: 259 WIQIDLGIA--------RGFDYYTSIVFEAIVPNDLGIGSIGGGGRYDNLIEVFGGKPTP 310
LGI+ RG DYYT +VFEA+ ++GGGGRYD L+ GG P
Sbjct: 247 AQLKALGISFAINPRLVRGLDYYTDLVFEAVTVVGEHSYALGGGGRYDELVAQSGGPSMP 306
Query: 311 ATGFAIGIERLIPILEWKGLLPELKAGPDVFVIPVGDSRDV-ATAIVTRLRKAGIRSDIE 369
A GF +G+ER+I L +G + +IP+ + D + RLR GI ++++
Sbjct: 307 AFGFGVGLERVIQTLLEQGNSLSTST-RRLRLIPMDEQADAFCFSWANRLRNLGIATEVD 365
Query: 370 LSGRKLRKALDYANRIGVRLSIIVGKRDLERGVVTIRDLE-----SGNQVEV 416
S +K + +L A V ++G+++L ++D+ SG Q +V
Sbjct: 366 WSHKKPKLSLKDAADQQVSFVCLLGEQELATKQFIVKDMSLHQSFSGAQQDV 417
>pir||E81347 histidine--tRNA ligase (EC 6.1.1.21) Cj0765c [imported] -
Campylobacter jejuni (strain NCTC 11168)
>gi|6968211|emb|CAB73030.1| (AL139076) histidyl-tRNA
synthetase [Campylobacter jejuni]
Length = 408
Score = 154 bits (385), Expect = 2e-36
Identities = 130/431 (30%), Positives = 199/431 (46%), Gaps = 37/431 (8%)
Query: 1 MIERVKGTRDFLPEEMVKRRWVFEKIREVFETYGFKEVLTPVMEYTKLFQLRSGEE---V 57
MI +KG +D L ++ V + EV + YGF + TP +E LF+ GE V
Sbjct: 1 MINALKGMKDLLDKDAYYYEKVIKICEEVAKNYGFTFINTPHLELCTLFKRSVGESSDIV 60
Query: 58 VKQLYAFKDKGGRDVALRPDMTSSVARLYVNSFQTAPKPIK-WYYIANMFRYEEPQSGRY 116
K++Y F DKG V +RP+ T+ V R Y+ +K W+Y +MFRYE PQ GR
Sbjct: 61 GKEMYEFIDKGENHVCMRPEGTAGVVRAYIEKKLDKNTSVKRWFYYGSMFRYERPQKGRL 120
Query: 117 REFWQAGVELIGSDKIEADAEVIALFVDSYLSTGLKDFTV---NIGDRVLLDEFAKMLGV 173
REF Q GVE +G + DA +I + V+ + G+ DF + ++G L ++
Sbjct: 121 REFHQFGVESLGIPNVYEDASIILMLVEIFSRLGI-DFKLQLNSLGCSQCLPKYRDR--- 176
Query: 174 KDDIGLMRIIDKKDKLSQEEF-LKALGEFGLDENGIEKVLNLIEIKGKPDDVLPLAEELF 232
L+ +D K+ ++ K L + + E NL+E + L L
Sbjct: 177 -----LVEFLDSKEGFCEDCLRRKNLNPIRVLDCKNEHCQNLLE------NAPLLINNLC 225
Query: 233 TSERAKEEISRLYNLVDILSWYEVDEWIQIDLGIARGFDYYTSIVFEAIVPNDLGIGSIG 292
TS + E L IL V ++D + RG DYY+ FE I +I
Sbjct: 226 TSCQKDFE-----TLQQILKDNGVK--FELDSKLVRGLDYYSKTAFEFISDEIGAKAAIA 278
Query: 293 GGGRYDNLIEVFGGKPTPATGFAIGIERLIPILEWKGLLPELKAGPDVFVIPVGDSRDVA 352
GGGRYD LIE GGK GFA+GIER+I ILE K E K + + D +
Sbjct: 279 GGGRYDRLIEYLGGKSGYGIGFAMGIERIITILEQK----EEKIQREGIYLCAMDEIYIQ 334
Query: 353 TA--IVTRLRKAGIRSDIELSGRKLRKALDYANRIGVRLSIIVGKRDLERGVVTIRDLES 410
I T LRK + + RKL K L+ A++ + + +G+ + + + ++L
Sbjct: 335 KLLHIATNLRKE-YKVLLSYEARKLAKHLENADKNNTEIFLCMGENEAQNESLFYKNLAK 393
Query: 411 GNQVEVPVDNV 421
+ + + ++
Sbjct: 394 KEEKMIKISDL 404
>pir||C82910 histidyl-tRNA synthetase UU285 [imported] - Ureaplasma urealyticum
>gi|6899258|gb|AAF30694.1|AE002125_5 (AE002125)
histidyl-tRNA synthetase [Ureaplasma urealyticum]
Length = 420
Score = 152 bits (380), Expect = 8e-36
Identities = 130/426 (30%), Positives = 205/426 (47%), Gaps = 27/426 (6%)
Query: 6 KGTRDFLPEEMVKRRWVFEKIREVFETYGFKEVLTPVMEYTKLFQLRSGEE---VVKQLY 62
+GT D +EM + + + + YGF+++ TPV E+ +LF +GE V K++Y
Sbjct: 8 RGTIDLYNKEMNDFKLLENFLLSTTKRYGFQQIKTPVFEFAELFMKSAGESSDLVSKEMY 67
Query: 63 AFKDKGGRDVALRPDMTSSVARLYVNS--FQTAPKPIKWYYIANMFRYEEPQSGRYREFW 120
FKDK R +ALRP+ T+ V R V + P P+K Y FRYE PQ+GR R+F
Sbjct: 68 LFKDKSDRWLALRPEGTAGVIRAVVENKLLLNHPLPLKLMYFEPCFRYERPQAGRQRQFH 127
Query: 121 QAGVELIGSDKIEADAEVIALFVDSYLSTGLKDFTVNIGDRVLLDEFAKMLGVKDDIGLM 180
Q GVE++G+ I D E+IAL + ++ + I + + L VK
Sbjct: 128 QFGVEVLGTKNIYYDFELIALADTILKKLMISNYILEI--NYISSPHNRSLWVKS----- 180
Query: 181 RIIDKKDKLSQEEFLKALGEFGLDENGIEKVLNLIEIKGKPDDVLPLAEELFTSERAKEE 240
+ + L + E L L + + N + + + +E + P F S KEE
Sbjct: 181 --LQEYFHLHRTE-LTPLSQERITTNPLRILDDKLESQKLVVKQAPKISH-FLSNEEKEE 236
Query: 241 ISRLYNLVDILSWYEVDEWIQIDLGIARGFDYYTSIVFEAI--VPNDLGIGSIGGGGRYD 298
+ + ++D Y + + ++ G+ RG DYY+ +VFE I P LG +I GGGRY
Sbjct: 237 FNLIKKMLDD---YNIKYY--VNEGLVRGLDYYSGLVFEFISTSPKLLGQSTIIGGGRYG 291
Query: 299 NLIEVFGGKPTPATGFAIGIERLIPILEWKGLLPELKAGPDVFVIPVGDSRDVATAI-VT 357
LI+ GG GF IGIERL+ L + L D ++I D AI +T
Sbjct: 292 ELIKQTGGPNYEGIGFGIGIERLLIALS-ETNKNILNTDDDKYLIAFFDKELENEAIKLT 350
Query: 358 RLRKAG--IRSDIELSGRKLRKALDYANRIGVRLSIIVGKRDLERGVVTIRDLESGNQVE 415
++ + + DI LS K K A R+ V+ II+ K++ + ++DL + Q
Sbjct: 351 QILRINNQLNVDIILSSTKADKIFKLAQRLNVKKLIILAKKEWSDKKIILKDLLNFKQDL 410
Query: 416 VPVDNV 421
+ +D +
Sbjct: 411 LSLDEI 416
>sp|P74592|HISZ_SYNY3 ATP PHOSPHORIBOSYLTRANSFERASE REGULATORY SUBUNIT
>gi|7469339|pir||S76788 histidine--tRNA ligase homolog -
Synechocystis sp. (strain PCC 6803)
>gi|1653789|dbj|BAA18700.1| (D90916) histidyl tRNA
synthetase [Synechocystis sp.]
Length = 401
Score = 140 bits (349), Expect = 3e-32
Identities = 112/397 (28%), Positives = 187/397 (46%), Gaps = 19/397 (4%)
Query: 7 GTRDFLPEEMVKRRWVFEKIREVFETYGFKEVLTPVMEYTKLFQLRSGEEVVKQLYAFKD 66
G RD LP E+ ++ + +++++ F +G++ ++T +E+ + G + +D
Sbjct: 8 GARDLLPLEVAQKARINDQLQQTFHRWGYQRIVTSTLEWLDTL-VAGGAISANNVIQLQD 66
Query: 67 KGGRDVALRPDMTSSVARLYVNSFQTAPKPIKWYYIANMFRYE-EPQSGRYREFWQAGVE 125
G + LRP++T+S+AR V T +P + Y AN+FR E G+ EF+QAG+E
Sbjct: 67 SGEGRLGLRPELTASIARAVVTRM-TDNQPQRLCYRANVFRNPPEGYHGKQMEFFQAGIE 125
Query: 126 LIGSDKIEADAEVIALFVDSYLSTGLKDFTVNIGDRVLLDEFAKMLGVKDDIGLMRIIDK 185
L+ + + ADAE++ L D GL D+ + +GD L L + I +
Sbjct: 126 LLFAGGVRADAEILLLLTDCLTQLGLSDWQLILGDAGLTRSLLAKLPPTLQATVRDCITR 185
Query: 186 KD--KLSQEEFLKALGEFGLDENGIEKVLNLIEIKGKPDDVLPLAEELFTSERAKEEISR 243
D +LSQ + D L L +++G ++VL +L + R
Sbjct: 186 LDYVELSQLPY--------PDNEAKNLALQLFDLRGTVEEVLARLGKLDLQGECLGLVDR 237
Query: 244 LYNLVDILSWY-EVDEWIQIDLGIARGFDYYTSIVFEAIVPNDLGIGSIGGGGRYDNLIE 302
L L+ +++ + + +DL + FDYYT +VF+A+ +G GGRYD L+
Sbjct: 238 LQALLCLVAASGDGPANLVLDLSWLQPFDYYTGMVFQAVSRQADNCYVLGQGGRYDQLLS 297
Query: 303 VFGGKPT--PATGFAIGIERLIPILEWKGLLPELKAGPDVFVIPVGDSRDVAT---AIVT 357
+ + P TGF++ IE L L G LP A D V PV D+ + AT A
Sbjct: 298 QYHPQQQSFPGTGFSLNIEELHQCLLELGTLPTSTAPIDYLVCPVDDTAEGATFRHAQQL 357
Query: 358 RLRKAGIRSDIELSGRKLRKALDYANRIGVRLSIIVG 394
R + R +++L GR + YA + V + VG
Sbjct: 358 RRQHPDRRVELDLGGRSPEELNTYAQAMAVGQIVWVG 394
>sp|P75069|SYH_MYCPN HISTIDYL-TRNA SYNTHETASE (HISTIDINE--TRNA LIGASE) (HISRS)
>gi|2146155|pir||S73435 histidine--tRNA ligase (EC
6.1.1.21) hisS - Mycoplasma pneumoniae (strain ATCC
29342) >gi|1673766|gb|AAB95757.1| (AE000013)
histidyl-tRNA synthetase [Mycoplasma pneumoniae]
Length = 414
Score = 138 bits (344), Expect = 1e-31
Identities = 117/424 (27%), Positives = 200/424 (46%), Gaps = 37/424 (8%)
Query: 1 MIERVKGTRDFLPEEMVKRRWVFEKIREVFETYGFKEVLTPVMEYTKLFQLRSGEE--VV 58
++++ +G +D+ EE++ W +I + +GF EV TP++EY + F+ + V
Sbjct: 3 VLQKPRGVKDWYGEELIYFNWTVHQITNLAWKWGFSEVKTPLLEYAEAFKRTNANADIVK 62
Query: 59 KQLYAFKDKGGRDVALRPDMTSSVARLYVNSFQTAPK--PIKWYYIANMFRYEEPQSGRY 116
K+LY F DK R +ALRP+ T+ + RL + P+ P++ + I M+RYE PQS RY
Sbjct: 63 KELYEFHDKSNRLLALRPEATAGIVRLVCENKLLQPQNYPLRLFTIGTMYRYERPQSNRY 122
Query: 117 REFWQAGVELIGSDKIEADAEVIALFVDSYLSTGLKDFTV---NIGDRVLLDEFAKMLGV 173
RE +Q E+IG + + L G++ + N+G+ + ++ + L
Sbjct: 123 REHYQFSCEVIGDTNPTVLLDTLLLGHAIIQQLGIEGVILKLNNLGNSATIQQWNQALQA 182
Query: 174 KDDIGLMRIIDKKDKLSQEEFLKALGEFGLDENGIEKVLNLIEIKGKPDDVLPLAEELFT 233
+ K +L++ L + L N + ++L+ K D LP +
Sbjct: 183 -------YLTQFKAQLTE------LSQSRLSTNPL-RILD-----DKVDGQLPFISDAPQ 223
Query: 234 SERAKEEISRLYN--LVDILSWYEVD-EWIQIDLGIARGFDYYTSIVFEAIVPNDLGIGS 290
E+ + + N L L+ +V EW + + RG DYYT +VFE + + +
Sbjct: 224 IEQFLDAEQQALNTWLQQQLTQQQVPFEW---NPTLVRGLDYYTGVVFEFVKDDT----T 276
Query: 291 IGGGGRYDNLIEVFGGKPTPATGFAIGIERLIPILE-WKGLLPELKAGPDVFVIPVGDSR 349
+ GG YDNL+E GG PT A GFA GIER I L K P + VI + ++
Sbjct: 277 VLAGGVYDNLVEELGGTPTKALGFACGIERSINCLSAVKKQAILANQPPRLLVIGLTEAA 336
Query: 350 DVATAIVTRLRKAGIRSDIELSGRKLRKALDYANRIGVRLSIIVGKRDLERGVVTIRDLE 409
++ +A I ++ + A R+G R ++G +LE+ +T++DL
Sbjct: 337 LEKLLQLSLGWRAYHPVTIYPKVIRIINGIRAAQRLGYRFLGVIGGNNLEQQTITVKDLA 396
Query: 410 SGNQ 413
+ Q
Sbjct: 397 TEQQ 400
>sp|P46220|SYH_SULSH PUTATIVE HISTIDYL-TRNA SYNTHETASE (HISTIDINE--TRNA LIGASE) (HISRS)
>gi|557202|gb|AAA72452.1| (L36863) homologous to
N-terminal part of Histidyl-tRNA synthetase (P30053);
ORF1 [Sulfolobus shibatae]
Length = 138
Score = 134 bits (335), Expect = 1e-30
Identities = 60/133 (45%), Positives = 93/133 (69%)
Query: 3 ERVKGTRDFLPEEMVKRRWVFEKIREVFETYGFKEVLTPVMEYTKLFQLRSGEEVVKQLY 62
E V+G +D++ + K R++ R++ YG+ E++TPV+E KLF L+ GEE+ + +Y
Sbjct: 5 ETVRGMKDYIGIDAEKIRYLESIFRDLAIKYGYSEIITPVVEEFKLFALKGGEELRETMY 64
Query: 63 AFKDKGGRDVALRPDMTSSVARLYVNSFQTAPKPIKWYYIANMFRYEEPQSGRYREFWQA 122
FKDK R+++LRP++T VAR Y+ + Q++PKPI+ +Y ++RY+EPQ GRYREF QA
Sbjct: 65 VFKDKADRELSLRPEITPGVARAYIQNLQSSPKPIRLFYFGTVYRYDEPQYGRYREFRQA 124
Query: 123 GVELIGSDKIEAD 135
G+E+IG I D
Sbjct: 125 GIEMIGDSSILDD 137
>pir||T48363 histidyl-tRNA synthetase-like protein - Arabidopsis thaliana
>gi|7378622|emb|CAB83298.1| (AL162751) histidyl-tRNA
synthetase-like protein [Arabidopsis thaliana]
Length = 333
Score = 128 bits (318), Expect = 1e-28
Identities = 60/146 (41%), Positives = 94/146 (64%)
Query: 6 KGTRDFLPEEMVKRRWVFEKIREVFETYGFKEVLTPVMEYTKLFQLRSGEEVVKQLYAFK 65
KGTRDF PE+M R W+F +EV +G++EV PV+E LF ++GEE+ QLY F+
Sbjct: 73 KGTRDFPPEDMRLRNWLFNHFKEVSRLFGYEEVDFPVLETEALFIRKAGEEIRDQLYCFE 132
Query: 66 DKGGRDVALRPDMTSSVARLYVNSFQTAPKPIKWYYIANMFRYEEPQSGRYREFWQAGVE 125
D+G R VALRP++T S+ARL + ++ P+KW+ + +RYE GR RE +Q ++
Sbjct: 133 DRGNRRVALRPELTPSLARLVIQKGKSVSLPLKWFAVGQCWRYERMTRGRRREHYQWNMD 192
Query: 126 LIGSDKIEADAEVIALFVDSYLSTGL 151
+IG ++ A+AE+I+ + + G+
Sbjct: 193 IIGVPEVTAEAELISSIMTFFKRIGI 218
>sp|P34183|SYH_CAEEL HISTIDYL-TRNA SYNTHETASE (HISTIDINE--TRNA LIGASE) (HISRS)
>gi|1708838|gb|AAB38116.1| (L13152) histidyl tRNA
synthetase [Caenorhabditis elegans]
Length = 525
Score = 126 bits (313), Expect = 5e-28
Identities = 113/395 (28%), Positives = 184/395 (45%), Gaps = 46/395 (11%)
Query: 6 KGTRDFLPEEMVKRRWVFEKIREVFETYGFKEVLTPVMEYTKLFQLRSGEEVVKQLYAFK 65
KGTRD+ P + R V + + E F YG + + TPV E + + GEE K +Y +
Sbjct: 26 KGTRDYGPAQSALRNSVLQTVTETFNRYGAETIDTPVFELRDVLMGKYGEEGGKLVYDLQ 85
Query: 66 DKGGRDVALRPDMTSSVAR-LYVNSFQTAPKPIKWYYIANMFRYEEP--QSGRYREFWQA 122
D+GG ++LR D+T AR L +N I Y IA ++R ++P GRYREF+Q
Sbjct: 86 DQGGELLSLRYDLTVPFARYLAMNKITN----ITRYQIAKVYRRDQPVMSRGRYREFYQC 141
Query: 123 GVELIGS-DKIEADAEVIALFVDSYLSTGLKDFTVNIGDRVLLDEFAKMLGV--KDDIGL 179
++ G D + + V L + + L+ F++ ++L+ + G+ KD +
Sbjct: 142 DFDIAGQYDLMLPELSVWELLMSCSRNWKLESFSLISITVLILEGMFAVSGIPAKDFKTI 201
Query: 180 MRIIDKKDKLSQEEF-LKALGEFGLDENGIEKVLNLIEIKG-----------KPDDVLPL 227
+DK DK E+ + + E L + K+ L+ + K LP
Sbjct: 202 CSSVDKLDKTPWEDVEQEMINEKFLTKEQTGKLGELVRFESSIAISTIWNFLKKCHNLP- 260
Query: 228 AEELFTSERAKEEISRLYNLVDILSWYEVDEWIQIDLGIARGFDYYTSIVFEAIVPNDL- 286
+L +++ K+ L L++ L+ V ++ + +ARG DYYT ++EA+ P L
Sbjct: 261 --DLGQNDKFKKGAEELKVLIEYLNVDGVTT-VRYEPSLARGLDYYTGAIYEAVAPKALE 317
Query: 287 ---------------GIGSIGGGGRYDNLIEVFGGKP-TPATGFAIGIERLIPILEWKGL 330
G+GS+ GGRYD L+++F K P G + GIERL I+E +
Sbjct: 318 GTAVENSEDTAGQPVGVGSVAAGGRYDGLVKMFDSKANVPCCGVSFGIERLFAIMEARQK 377
Query: 331 LPELKAGPDVFVIPVGDS--RDVATAIVTRLRKAG 363
+ +V+V + RD +V LR AG
Sbjct: 378 VAIRTTQTEVYVASAQKNLVRD-RKKLVKMLRSAG 411
>gb|AAD14008.1|S68230_1 (S68230) histidyl tRNA synthetase [Caenorhabditis elegans]
Length = 514
Score = 126 bits (313), Expect = 5e-28
Identities = 113/395 (28%), Positives = 184/395 (45%), Gaps = 46/395 (11%)
Query: 6 KGTRDFLPEEMVKRRWVFEKIREVFETYGFKEVLTPVMEYTKLFQLRSGEEVVKQLYAFK 65
KGTRD+ P + R V + + E F YG + + TPV E + + GEE K +Y +
Sbjct: 15 KGTRDYGPAQSALRNSVLQTVTETFNRYGAETIDTPVFELRDVLMGKYGEEGGKLVYDLQ 74
Query: 66 DKGGRDVALRPDMTSSVAR-LYVNSFQTAPKPIKWYYIANMFRYEEP--QSGRYREFWQA 122
D+GG ++LR D+T AR L +N I Y IA ++R ++P GRYREF+Q
Sbjct: 75 DQGGELLSLRYDLTVPFARYLAMNKITN----ITRYQIAKVYRRDQPVMSRGRYREFYQC 130
Query: 123 GVELIGS-DKIEADAEVIALFVDSYLSTGLKDFTVNIGDRVLLDEFAKMLGV--KDDIGL 179
++ G D + + V L + + L+ F++ ++L+ + G+ KD +
Sbjct: 131 DFDIAGQYDLMLPELSVWELLMSCSRNWKLESFSLISITVLILEGMFAVSGIPAKDFKTI 190
Query: 180 MRIIDKKDKLSQEEF-LKALGEFGLDENGIEKVLNLIEIKG-----------KPDDVLPL 227
+DK DK E+ + + E L + K+ L+ + K LP
Sbjct: 191 CSSVDKLDKTPWEDVEQEMINEKFLTKEQTGKLGELVRFESSIAISTIWNFLKKCHNLP- 249
Query: 228 AEELFTSERAKEEISRLYNLVDILSWYEVDEWIQIDLGIARGFDYYTSIVFEAIVPNDL- 286
+L +++ K+ L L++ L+ V ++ + +ARG DYYT ++EA+ P L
Sbjct: 250 --DLGQNDKFKKGAEELKVLIEYLNVDGVTT-VRYEPSLARGLDYYTGAIYEAVAPKALE 306
Query: 287 ---------------GIGSIGGGGRYDNLIEVFGGKP-TPATGFAIGIERLIPILEWKGL 330
G+GS+ GGRYD L+++F K P G + GIERL I+E +
Sbjct: 307 GTAVENSEDTAGQPVGVGSVAAGGRYDGLVKMFDSKANVPCCGVSFGIERLFAIMEARQK 366
Query: 331 LPELKAGPDVFVIPVGDS--RDVATAIVTRLRKAG 363
+ +V+V + RD +V LR AG
Sbjct: 367 VAIRTTQTEVYVASAQKNLVRD-RKKLVKMLRSAG 400
>pir||S41763 histidine--tRNA ligase (EC 6.1.1.21) - Caenorhabditis elegans
Length = 525
Score = 123 bits (307), Expect = 3e-27
Identities = 112/395 (28%), Positives = 183/395 (45%), Gaps = 46/395 (11%)
Query: 6 KGTRDFLPEEMVKRRWVFEKIREVFETYGFKEVLTPVMEYTKLFQLRSGEEVVKQLYAFK 65
KGTRD+ P + R V + + E F YG + + TPV E + + GEE K +Y +
Sbjct: 26 KGTRDYGPAQSALRNSVLQTVTETFNRYGAETIDTPVFELRDVLMGKYGEEGGKLVYDLQ 85
Query: 66 DKGGRDVALRPDMTSSVAR-LYVNSFQTAPKPIKWYYIANMFRYEEP--QSGRYREFWQA 122
D+GG ++LR D+T AR L +N I Y IA ++R ++P GRYREF+Q
Sbjct: 86 DQGGELLSLRYDLTVPFARYLAMNKITN----ITRYQIAKVYRRDQPVMSRGRYREFYQC 141
Query: 123 GVELIGS-DKIEADAEVIALFVDSYLSTGLKDFTVNIGDRVLLDEFAKMLGV--KDDIGL 179
++ G D + + V L + + L+ F+ + ++L+ + G+ KD +
Sbjct: 142 DFDIAGQYDLMLPELSVWELLMSCSRNWKLESFSFSSITVLILEGMFAVSGIPAKDFKTI 201
Query: 180 MRIIDKKDKLSQEEF-LKALGEFGLDENGIEKVLNLIEIKG-----------KPDDVLPL 227
+DK DK E+ + + E L + K+ L+ + K LP
Sbjct: 202 CSSVDKLDKTPWEDVEQEMINEKFLTKEQTGKLGELVRFESSIAISTIWNFLKKCHNLP- 260
Query: 228 AEELFTSERAKEEISRLYNLVDILSWYEVDEWIQIDLGIARGFDYYTSIVFEAIVPNDL- 286
+L +++ K+ L L++ L+ V ++ + +ARG DYYT ++EA+ L
Sbjct: 261 --DLGQNDKFKKGAEELKVLIEYLNVDGVTT-VRYEPSLARGLDYYTGAIYEAVASEALE 317
Query: 287 ---------------GIGSIGGGGRYDNLIEVFGGKP-TPATGFAIGIERLIPILEWKGL 330
G+GS+ GGRYD L+++F K P G + GIERL I+E +
Sbjct: 318 GTAVENSEDTAGQPVGVGSVAAGGRYDGLVKMFDSKANVPCCGVSFGIERLFAIMEARQK 377
Query: 331 LPELKAGPDVFVIPVGDS--RDVATAIVTRLRKAG 363
+ +V+V + RD +V LR AG
Sbjct: 378 VAIRTTQTEVYVASAQKNLVRD-RKKLVKMLRSAG 411
>sp|O67223|HISZ_AQUAE ATP PHOSPHORIBOSYLTRANSFERASE REGULATORY SUBUNIT
>gi|7437815|pir||D70399 histidine--tRNA ligase (EC
6.1.1.21) - Aquifex aeolicus >gi|2983619|gb|AAC07188.1|
(AE000726) histidyl-tRNA synthetase [Aquifex aeolicus]
Length = 383
Score = 120 bits (298), Expect = 3e-26
Identities = 131/434 (30%), Positives = 200/434 (45%), Gaps = 67/434 (15%)
Query: 5 VKGTRDFLPEEMVKRRWVFEKIREVFETYGFKEVLTPVMEYTKLFQLRSGEEVVKQLYAF 64
+ G R + EE + +F+K ++FE +G+ + E + +L GE K+ F
Sbjct: 6 ISGERFYSLEESNLVKEIFKKAVKIFEAFGYDYINLSHFEPYEFQELTFGEGS-KEAITF 64
Query: 65 KDKGGRD-VALRPDMTSSVARLYVNSFQTAPKPIKWYYIANMFRYEEPQSGRYREFWQAG 123
KD ++ LR D T+ V R ++ + P + YY +F + R E Q G
Sbjct: 65 KDSYTKESFGLRLDFTTQVVRT-ISHLRNVKLPERVYYFGKVFSLDR----RGFEKLQTG 119
Query: 124 VELIGSDKIEADAEVIALFVDSYLSTGLKDFTVNIGDRVLLDEFAKMLGVKDDIGLMRII 183
VELIG I AD EVI + + S GLKD +V+L + V D+
Sbjct: 120 VELIGEKSILADFEVIQVLTEFLKSLGLKDL------KVILSHAGIVRKVADE------- 166
Query: 184 DKKDKLSQEEFLKALGEFGLDENGIEKVLN-----LIEIKGKPDDVLPLAEELFTSERAK 238
+EE L+A E L+ +++VL +E+ P +VL E+ + E+ K
Sbjct: 167 -------REELLRAFSERNLE--ALKEVLGNDIKFFVEVSKNP-EVLNFLEK-YDLEKEK 215
Query: 239 EEISRLYNLVDILSWYEVDEWIQIDLGIARGFDYYTSIVFEAIVPNDLGIG-SIGGGGRY 297
EE L L +L + +D DLG R F YYT ++FE +L G ++ GGGRY
Sbjct: 216 EE---LLELGKLLEEFGID--YAYDLGEVRNFPYYTGVIFEIY---ELKSGKALAGGGRY 267
Query: 298 DNLIEVFGGKPTPATGFAIGIERLIPILEWKGLLPELKAGPDVFVIPVGDSRDVATAIVT 357
DNL +++ GK PATG A+ +ERL+ I LP+ D FVI R + +
Sbjct: 268 DNLSKIY-GKEYPATGGAVYLERLLDI------LPKNVEKKDYFVIDKTKKR-LGLKLAD 319
Query: 358 RLRKAGIRSDIEL-SGRKLRKALDYANRIGVRLSIIVGKRDLERGVVTIRDLESGNQVEV 416
LR+ G + +E+ R L +L YA G + ++V E +V +
Sbjct: 320 VLREKGKKVGMEIVKERGLEHSLIYAFDKGFKEVLLV-----EDEIVKV--------YTT 366
Query: 417 PVDNVVTKVRELLN 430
P D VV K+RE L+
Sbjct: 367 PKDYVVMKIREFLD 380
>pir||B75394 probable histidyl-tRNA synthetase - Deinococcus radiodurans
(strain R1) >gi|6459205|gb|AAF11015.1|AE001989_3
(AE001989) histidyl-tRNA synthetase, putative
[Deinococcus radiodurans]
Length = 406
Score = 104 bits (256), Expect = 3e-21
Identities = 93/323 (28%), Positives = 153/323 (46%), Gaps = 25/323 (7%)
Query: 7 GTRDFLPEEMVKRRWVFEKIREVFETYGFKEVLTPVMEYTKLFQLRSGEEVVKQLYAFK- 65
G RD LP E +R + + + ++G++ V P +E + +AFK
Sbjct: 31 GVRDVLPAEWERREHLRSHLSALLRSWGYRGVDLPALELADPAHPQGN-------HAFKL 83
Query: 66 -DKGGRDVALRPDMTSSVARLYVNSFQTAPKPIKWYYIANMF-RYEEPQSGRYREFWQAG 123
D GG+ +ALR + T+++ RL F + P P++ Y ++ R + + GR REF Q G
Sbjct: 84 IDSGGQVLALRSEYTTALGRLVGTHFPSGPFPLRLQYGGRLWLRTQTSELGRLREFNQVG 143
Query: 124 VELIGSDKIEADAEVIALFVDSYLSTGLKDFTVNIGDRVLLDEFAKMLGVKDDIGLMRII 183
ELIG ++ADAE++AL + G++ + +G +D G+ + +
Sbjct: 144 AELIGVTGVQADAELLALAHAALGQAGVQ-AQLEVGFPGFVDAALTDAGLPGPV-RAALH 201
Query: 184 DKKDKLSQEEFLKALGEFGLDENGIEKVLNLIEIKGKPDDVLPLAEELFTSERAKEEISR 243
D D+ S + + G+ + +L E+ G P +VL A L RA++ +
Sbjct: 202 DAIDRKSGADLDLLARQHGVSPEVTRTLHSLTELYGGP-EVLTEARVLARGVRAEQAVEH 260
Query: 244 LYNLVDILSWYEVDEWIQIDLGIARGFDYYTSIVFEAIVPNDLGIGS-IGGGGRYDNLIE 302
L + + E + DLG++R + YYT + F A V GI + GGGRY
Sbjct: 261 LSAV--HAAAQEAGVELLFDLGVSRRYGYYTGLTFRAYVD---GINQPVLGGGRY----A 311
Query: 303 VFGGKPTPATGFAIGIERLIPIL 325
+ GG P GFAIG+ERL ++
Sbjct: 312 LPGG--LPGAGFAIGLERLAAVM 332
>gb|AAC46133.1| (AF010189) HisX [Pseudomonas stutzeri]
Length = 395
Score = 101 bits (248), Expect = 2e-20
Identities = 94/374 (25%), Positives = 167/374 (44%), Gaps = 25/374 (6%)
Query: 7 GTRDFLPEEMVKRRWVFEKIREVFETYGFKEVLTPVMEYTKLFQLRSGEEV-VKQLYAFK 65
G + LP E + ++ ++F+ +G++ V+TP +E+ + SG+++ +K
Sbjct: 12 GIEEVLPPEAARIETARRRVLDLFQRWGYELVITPHVEFLESLLSGSGQDLDLKTFKVID 71
Query: 66 DKGGRDVALRPDMTSSVARLYVNSFQTAPKPIKWYYIANMFRYEEPQSGRYREFWQAGVE 125
GR + LR D+T VAR+ ++ + P + Y ++ + R Q G E
Sbjct: 72 PLSGRQMGLRADITPQVARVDAHTLRREG-PSRLCYAGSVLHAKPRALATSRSPIQLGAE 130
Query: 126 LIGSDKIEADAEVIALFVDSYLSTGLKDFTVNIGDRVLLDEFAKMLGVKDDIGLMRIIDK 185
L G +D EVI+L ++ + D +++G + A+ G+ + R+ D
Sbjct: 131 LYGDSSTSSDIEVISLMLEMLELAMVPDVHMDLGHVGIYRGLARAAGLSGEAE-QRLFDA 189
Query: 186 KDKLSQEEFLKALGEFGLDENGIEKVLNLIEIKGKPDDVLPLAEELFTSERAK--EEISR 243
+ + +E + E + +L + + L A + A E +
Sbjct: 190 MQRKAMDEIAELTATV---EPSLAAMLQALARLCGGRETLDAARRVLAEAPAPVTEALEA 246
Query: 244 LYNLVDILSWYEVDEWIQIDLGIARGFDYYTSIVFEAIVPNDLGIG-SIGGGGRYDNLIE 302
L + D L+ D + DLG RG+ Y+T +VF VP G+G SI GGRYD++
Sbjct: 247 LIRIADQLALRYPDLPLYFDLGELRGYHYHTGVVFAVFVP---GVGQSIAQGGRYDDIGA 303
Query: 303 VFGGKPTPATGFAIGIERLIPILEWKGLLPELKAGPDVFVIPVGDSRDVATAI---VTRL 359
F G+ PATGF+ ++ L+ + + EL + P GD TA+ ++RL
Sbjct: 304 DF-GRARPATGFSTDLKTLVSLGK-----AELDSRLSGIWAPYGDD----TALWQQISRL 353
Query: 360 RKAGIRSDIELSGR 373
R+ G R L G+
Sbjct: 354 RREGERVVQALDGQ 367
>pir||G83027 conserved hypothetical protein PA4939 [imported] - Pseudomonas
aeruginosa (strain PAO1)
>gi|9951219|gb|AAG08324.1|AE004907_2 (AE004907)
conserved hypothetical protein [Pseudomonas aeruginosa]
Length = 394
Score = 94.4 bits (231), Expect = 2e-18
Identities = 79/321 (24%), Positives = 149/321 (45%), Gaps = 11/321 (3%)
Query: 7 GTRDFLPEEMVKRRWVFEKIREVFETYGFKEVLTPVMEYTKLFQLRSGEEVVKQLYAFKD 66
G + LP E + ++ ++F +G++ V+TP +EY + +G+++ + + D
Sbjct: 12 GIEEVLPPEAARIEAARRQVLDLFHRWGYEFVVTPHIEYLESLLTGAGQDLDLRTFKVTD 71
Query: 67 KG-GRDVALRPDMTSSVARLYVNSFQTAPKPIKWYYIANMFRYEEPQSGRYREFWQAGVE 125
GR + R D+T VAR+ +S + P + Y ++ + R Q G E
Sbjct: 72 PASGRLMGFRADITPQVARMDAHSLRREG-PSRLCYAGSVLHAQPRALSTSRSPIQLGAE 130
Query: 126 LIGSDKIEADAEVIALFVDSYLSTGLKDFTVNIGDRVLLDEFAKMLGVKDDIGLMRIIDK 185
L G +D EVI+L ++ + D +++G + A+ G+ ++ ++ D
Sbjct: 131 LYGDPSPASDVEVISLMLEMLEMAEVPDVHMDLGHVGIYRGLARAAGLSGEVE-QQLFDA 189
Query: 186 KDKLSQEEFLKALGEFGLDENGIEKVLNLIEIKGKPDDVLPLAEELFTSER-AKEEISRL 244
+ + +E + + G+ + L E+ G D + L + + ++ L
Sbjct: 190 LQRKAVDEVEALTADLPAELRGMLRAL--AELCGGRDALEQGRARLAAAPADVQVALNEL 247
Query: 245 YNLVDILSWYEVDEWIQIDLGIARGFDYYTSIVFEAIVPNDLGIG-SIGGGGRYDNLIEV 303
+ D L+ + DLG RG+ Y+T +VF A VP G+G SI GGRYD++
Sbjct: 248 IEIADSLAGRFPGLPLYFDLGELRGYHYHTGVVFAAFVP---GVGQSIAQGGRYDDIGAD 304
Query: 304 FGGKPTPATGFAIGIERLIPI 324
F G+ PATGF+ ++ L+ +
Sbjct: 305 F-GRARPATGFSTDLKSLVTL 324
>sp|Q02147|HISZ_LACLA ATP PHOSPHORIBOSYLTRANSFERASE REGULATORY SUBUNIT
>gi|477937|pir||C45734 histidyl-tRNA synthetase homolog
- Lactococcus lactis subsp. lactis
>gi|2565140|gb|AAB81902.1| (U92974) unknown [Lactococcus
lactis]
Length = 328
Score = 94.0 bits (230), Expect = 3e-18
Identities = 85/326 (26%), Positives = 144/326 (44%), Gaps = 25/326 (7%)
Query: 12 LPEEMVKR--------RWVFEKIREVFETYGFKEVLTPVMEYTKLFQ-LRSGEEVVKQ-- 60
LPEE + R + ++R++F ++EV+ P EYT+L+ L S + Q
Sbjct: 8 LPEESAEMTLNQVKSLRQIEGRLRKLFSLKNYQEVMPPSFEYTQLYTALESNGKTFNQEK 67
Query: 61 LYAFKDKGGRDVALRPDMTSSVARLYVNSFQTAPKPIKWYYIANMFRYEEPQSGRYREFW 120
++ F + G+ + LR D T + RLY + ++ Y +FR E+ GR E +
Sbjct: 68 MFQFINHEGQSITLRYDFTLPLVRLYSQIKDSTSA--RYSYFGKIFRKEKRHKGRSTENY 125
Query: 121 QAGVELIGSDKIEADAEVIALFVDSYLSTGLKDFTVNIGDRVLLDEFAKMLGVKDDIGLM 180
Q G+EL G +++ E+++L + GL IG + ++ L
Sbjct: 126 QIGIELFGESADKSELEILSLALQVIEQLGLNKTVFEIGSAKFFQRLCHLADGSTEL-LT 184
Query: 181 RIIDKKDKLSQEEFLKALGEFGLDENGIEKVLNLIEIKGKPDDVLPLAEELFTSERAKEE 240
++ KKD L L F +++N K L + + + L E L T+ +
Sbjct: 185 ELLLKKD-------LSGLNAF-IEKNNFSKELRELLKEIFITNELSRLENLVTNTKDDVL 236
Query: 241 ISRLYNLVDILSWYEVDEWIQIDLGIARGFDYYTSIVFEAIVPNDLGIGSIGGGGRYDNL 300
IS L + + + I IDLG+ DYYT ++F+A + I GGRYD L
Sbjct: 237 ISSFDQLKEFSEKLSMIKPIIIDLGMVPKMDYYTDLMFKAY--SSAANQPILSGGRYDQL 294
Query: 301 IEVFGGKPTPATGFAIGIERLIPILE 326
+ F + A GF ++ ++ LE
Sbjct: 295 LSNF-QEEAVAIGFCCHMDTILKALE 319
Database: ./suso.pep
Posted date: Jul 6, 2001 5:57 PM
Number of letters in database: 840,471
Number of sequences in database: 2977
Database: /banques/blast2/nr.pep
Posted date: Dec 14, 2000 12:46 PM
Number of letters in database: 188,266,275
Number of sequences in database: 595,510
Lambda K H
0.320 0.142 0.407
Gapped
Lambda K H
0.270 0.0470 0.230
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 164238226
Number of Sequences: 2977
Number of extensions: 7691342
Number of successful extensions: 19377
Number of sequences better than 1.0e-10: 80
Number of HSP's better than 0.0 without gapping: 35
Number of HSP's successfully gapped in prelim test: 45
Number of HSP's that attempted gapping in prelim test: 19011
Number of HSP's gapped (non-prelim): 108
length of query: 431
length of database: 189,106,746
effective HSP length: 56
effective length of query: 375
effective length of database: 155,591,474
effective search space: 58346802750
effective search space used: 58346802750
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 41 (21.7 bits)
S2: 166 (69.1 bits)