BLASTP 2.0.10 [Aug-26-1999]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= PAB1111 (trpS) DE:tryptophanyl-tRNA synthetase (trpS)
(385 letters)
Database: ./suso.pep; /banques/blast2/nr.pep
598,487 sequences; 189,106,746 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
pir||C75020 tryptophanyl-tRNA synthetase (trps) PAB1111 - Pyroco... 802 0.0
pir||G71206 tryptophan--tRNA ligase (EC 6.1.1.2) - Pyrococcus ho... 605 e-172
gb|AAK40778.1| Tryptophanyl-tRNA synthetase (trpS) [Sulfolobus s... 473 e-132
gi|6324475 cytoplasmic tryptophanyl-tRNA synthetase; Wrs1p [Sacc... 344 1e-93
sp|Q09692|SYW_SCHPO PUTATIVE TRYPTOPHANYL-TRNA SYNTHETASE (TRYPT... 329 3e-89
emb|CAA44450.1| (X62570) IFP53 [Homo sapiens] 311 7e-84
gi|11433596 tryptophanyl-tRNA synthetase [Homo sapiens] >gi|1351... 311 1e-83
gb|AAF20167.1|AF125157_1 (AF125157) tryptophanyl-tRNA synthetase... 309 3e-83
gb|AAF20166.1|AF125156_1 (AF125156) tryptophanyl-tRNA synthetase... 309 3e-83
gi|4759316 tryptophanyl-tRNA synthetase; interferon-induced prot... 308 6e-83
gb|AAF54352.1| (AE003682) Aats-trp gene product [alt 1] [Drosoph... 308 8e-83
sp|P23612|SYW_RABIT TRYPTOPHANYL-TRNA SYNTHETASE (TRYPTOPHAN--TR... 304 1e-81
pir||YWRBPR tryptophan--tRNA ligase (EC 6.1.1.2) [validated] - r... 301 8e-81
sp|P17248|SYW_BOVIN TRYPTOPHANYL-TRNA SYNTHETASE (TRYPTOPHAN--TR... 301 1e-80
emb|CAA36356.1| (X52113) tryptophan tRNA ligase (AA 1-459) [Bos ... 301 1e-80
emb|CAA49347.1| (X69656) tryptophan--tRNA ligase [Mus musculus] 296 4e-79
gi|6755991 tryptophanyl-tRNA synthetase [Mus musculus] >gi|41784... 296 4e-79
gb|AAA31246.1| (M33460) eucaryotic release factor (eRF) [Oryctol... 293 2e-78
gb|AAF04890.1|AC011437_5 (AC011437) putative tryptophanyl-tRNA s... 293 3e-78
sp|Q58810|SYW_METJA TRYPTOPHANYL-TRNA SYNTHETASE (TRYPTOPHAN--TR... 250 3e-65
emb|CAB60439.1| (AL132853) contains similarity to Pfam domain: P... 249 4e-65
dbj|BAA25288.1| (AB012222) tryptophan-tRNA synthetase [Cavia por... 241 1e-62
emb|CAB94199.1| (X67923) tryptophanyl-tRNA synthetase [Homo sapi... 223 3e-57
sp|O26352|SYW_METTH TRYPTOPHANYL-TRNA SYNTHETASE (TRYPTOPHAN--TR... 220 2e-56
gb|AAG20355.1| (AE005109) tryptophanyl-tRNA synthetase; TrpS2 [H... 210 3e-53
emb|CAB58393.1| (AL121862) tryptophanyl-tRNA synthetase [Leishma... 199 4e-50
sp|Q9Y924|SYW_AERPE TRYPTOPHANYL-TRNA SYNTHETASE (TRYPTOPHAN--TR... 190 2e-47
gi|11499284 tryptophanyl-tRNA synthetase (trpS) [Archaeoglobus f... 164 2e-39
gb|AAB60257.1| (U02595) tryptophanyl tRNA synthetase [Oryctolagu... 144 2e-33
sp|O96771|SYW_ENCCU TRYPTOPHANYL-TRNA SYNTHETASE (TRYPTOPHAN--TR... 115 9e-25
gb|AAG20338.1| (AE005107) tryptophanyl-tRNA synthetase; TrpS1 [H... 94 2e-18
emb|CAC12336.1| (AL445066) tryptophanyl-tRNA synthetase related ... 92 8e-18
sp|O67115|SYW_AQUAE TRYPTOPHANYL-TRNA SYNTHETASE (TRYPTOPHAN--TR... 89 9e-17
sp|Q9WYW2|SYW_THEMA TRYPTOPHANYL-TRNA SYNTHETASE (TRYPTOPHAN--TR... 73 4e-12
sp|Q9Z7A4|SYW_CHLPN TRYPTOPHANYL-TRNA SYNTHETASE (TRYPTOPHAN--TR... 71 2e-11
gb|AAF15095.1|AF110953_1 (AF110953) tryptophanyl-tRNA synthetase... 69 8e-11
gb|AAG20359.1| (AE005109) tyrosyl-tRNA synthetase; TyrS [Halobac... 69 8e-11
>pir||C75020 tryptophanyl-tRNA synthetase (trps) PAB1111 - Pyrococcus abyssi
(strain Orsay) >gi|5459115|emb|CAB50601.1| (AJ248288)
tryptophanyl-tRNA synthetase (trpS) [Pyrococcus abyssi]
Length = 385
Score = 802 bits (2050), Expect = 0.0
Identities = 385/385 (100%), Positives = 385/385 (100%)
Query: 1 MVEDFKVTPWEVEGVVDYNKLIEHFGTSPLTEELLEKTAELTKSELPLFFRRKFFFSHRD 60
MVEDFKVTPWEVEGVVDYNKLIEHFGTSPLTEELLEKTAELTKSELPLFFRRKFFFSHRD
Sbjct: 1 MVEDFKVTPWEVEGVVDYNKLIEHFGTSPLTEELLEKTAELTKSELPLFFRRKFFFSHRD 60
Query: 61 YDKVLQDYEEGRGFFLYTGRGPSGPMHIGHIIPFFATKWLQEKFGVNLYIQITDDEKFLF 120
YDKVLQDYEEGRGFFLYTGRGPSGPMHIGHIIPFFATKWLQEKFGVNLYIQITDDEKFLF
Sbjct: 61 YDKVLQDYEEGRGFFLYTGRGPSGPMHIGHIIPFFATKWLQEKFGVNLYIQITDDEKFLF 120
Query: 121 KENLTFEDTKHWAYENILDIIAVGFDPDKTFIFQNSEFTKIYEMAIPIAKKINFSMAKAV 180
KENLTFEDTKHWAYENILDIIAVGFDPDKTFIFQNSEFTKIYEMAIPIAKKINFSMAKAV
Sbjct: 121 KENLTFEDTKHWAYENILDIIAVGFDPDKTFIFQNSEFTKIYEMAIPIAKKINFSMAKAV 180
Query: 181 FGFTEQSKIGMIFFPAIQIAPTFFEKRRCLIPAAIDQDPYWRLQRDFAESLGYYKTAAIH 240
FGFTEQSKIGMIFFPAIQIAPTFFEKRRCLIPAAIDQDPYWRLQRDFAESLGYYKTAAIH
Sbjct: 181 FGFTEQSKIGMIFFPAIQIAPTFFEKRRCLIPAAIDQDPYWRLQRDFAESLGYYKTAAIH 240
Query: 241 SKFVPSLTSLSGKMSASKPETAIYLTDSPEDVEKKVWKFALTGGRPTLKEQREKGGEPEK 300
SKFVPSLTSLSGKMSASKPETAIYLTDSPEDVEKKVWKFALTGGRPTLKEQREKGGEPEK
Sbjct: 241 SKFVPSLTSLSGKMSASKPETAIYLTDSPEDVEKKVWKFALTGGRPTLKEQREKGGEPEK 300
Query: 301 CVVFKWLEIFFEEDDKKLKERYYACKNGELTCGECKRYLISKIQEFLKEHQKRRKKAEKQ 360
CVVFKWLEIFFEEDDKKLKERYYACKNGELTCGECKRYLISKIQEFLKEHQKRRKKAEKQ
Sbjct: 301 CVVFKWLEIFFEEDDKKLKERYYACKNGELTCGECKRYLISKIQEFLKEHQKRRKKAEKQ 360
Query: 361 IEKFKYTGKLAQEMWDKAIPEPLKG 385
IEKFKYTGKLAQEMWDKAIPEPLKG
Sbjct: 361 IEKFKYTGKLAQEMWDKAIPEPLKG 385
>pir||G71206 tryptophan--tRNA ligase (EC 6.1.1.2) - Pyrococcus horikoshii
>gi|3258363|dbj|BAA31046.1| (AP000007) 301aa long
hypothetical tryptophanyl-tRNA synthetase [Pyrococcus
horikoshii]
Length = 301
Score = 605 bits (1542), Expect = e-172
Identities = 287/299 (95%), Positives = 296/299 (98%)
Query: 86 MHIGHIIPFFATKWLQEKFGVNLYIQITDDEKFLFKENLTFEDTKHWAYENILDIIAVGF 145
MHIGHIIPFFATKWLQEKFGVNLYIQITDDEKFLFKENLTF+DTK WAY+NILDIIAVGF
Sbjct: 1 MHIGHIIPFFATKWLQEKFGVNLYIQITDDEKFLFKENLTFDDTKRWAYDNILDIIAVGF 60
Query: 146 DPDKTFIFQNSEFTKIYEMAIPIAKKINFSMAKAVFGFTEQSKIGMIFFPAIQIAPTFFE 205
DPDKTFIFQNSEFTKIYEMAIPIAKKINFSMAKAVFGFTEQSKIGMIFFPAIQIAPTFFE
Sbjct: 61 DPDKTFIFQNSEFTKIYEMAIPIAKKINFSMAKAVFGFTEQSKIGMIFFPAIQIAPTFFE 120
Query: 206 KRRCLIPAAIDQDPYWRLQRDFAESLGYYKTAAIHSKFVPSLTSLSGKMSASKPETAIYL 265
++RCLIPAAIDQDPYWRLQRDFAESLGYYKTAA+HSKFVPSLTSLSGKMSASKPETAIYL
Sbjct: 121 RKRCLIPAAIDQDPYWRLQRDFAESLGYYKTAALHSKFVPSLTSLSGKMSASKPETAIYL 180
Query: 266 TDSPEDVEKKVWKFALTGGRPTLKEQREKGGEPEKCVVFKWLEIFFEEDDKKLKERYYAC 325
TDSPEDVEKKVWKF LTGGRPTLKEQREKGGEPEKCVVFKWLEIFFEEDDKKLKERYYAC
Sbjct: 181 TDSPEDVEKKVWKFTLTGGRPTLKEQREKGGEPEKCVVFKWLEIFFEEDDKKLKERYYAC 240
Query: 326 KNGELTCGECKRYLISKIQEFLKEHQKRRKKAEKQIEKFKYTGKLAQEMWDKAIPEPLK 384
KNGELTCGECKRYLISKIQEFLKEHQ+RRKKAEK +EKFKYTGKLAQEMW++AIPEPLK
Sbjct: 241 KNGELTCGECKRYLISKIQEFLKEHQRRRKKAEKLVEKFKYTGKLAQEMWNEAIPEPLK 299
>gb|AAK40778.1| Tryptophanyl-tRNA synthetase (trpS) [Sulfolobus solfataricus]
Length = 386
Score = 473 bits (1205), Expect = e-132
Identities = 222/378 (58%), Positives = 285/378 (74%), Gaps = 2/378 (0%)
Query: 1 MVEDFKVTPWEVEGVVDYNKLIEHFGTSPLTEELLEKTAELTKSELPLFFRRKFFFSHRD 60
M ++F VTPWEV+G VDY+KLI FGT +TEEL ++ L +L + RR FFSHRD
Sbjct: 7 MPDEFTVTPWEVKGKVDYDKLIVQFGTQKITEELKQRIKNLA-GDLHVMLRRNVFFSHRD 65
Query: 61 YDKVLQDYEEGRGFFLYTGRGPSGPMHIGHIIPFFATKWLQEKFGVNLYIQITDDEKFLF 120
D VL DYE+ +GFFLYTGR PS MHIGH+IPF TKWLQEKF NLYI+ITDDEK++
Sbjct: 66 LDLVLNDYEKSKGFFLYTGRAPSLGMHIGHLIPFIFTKWLQEKFNANLYIEITDDEKYMR 125
Query: 121 KENLTFEDTKHWAYENILDIIAVGFDPDKTFIFQNSEFTK-IYEMAIPIAKKINFSMAKA 179
T + T+ WAY+NILDIIAVGF+PDKTFIFQ++E+ + +Y + + IAKK+ FS +A
Sbjct: 126 NPEFTLDQTRSWAYDNILDIIAVGFNPDKTFIFQDTEYIRNMYPITVKIAKKLTFSEVRA 185
Query: 180 VFGFTEQSKIGMIFFPAIQIAPTFFEKRRCLIPAAIDQDPYWRLQRDFAESLGYYKTAAI 239
FG S IG+IF+PA+QIAPT FEK+RCLIPA IDQDPYWRLQRD AESLGYYK A I
Sbjct: 186 TFGLDASSNIGLIFYPALQIAPTMFEKKRCLIPAGIDQDPYWRLQRDIAESLGYYKAAQI 245
Query: 240 HSKFVPSLTSLSGKMSASKPETAIYLTDSPEDVEKKVWKFALTGGRPTLKEQREKGGEPE 299
HSKF+P LT GKMS+S PETAIYL D P+ VE+K+ K+A +GG+PT++ R+ GG PE
Sbjct: 246 HSKFLPPLTGPEGKMSSSNPETAIYLVDDPKTVERKIMKYAFSGGQPTIELHRKYGGNPE 305
Query: 300 KCVVFKWLEIFFEEDDKKLKERYYACKNGELTCGECKRYLISKIQEFLKEHQKRRKKAEK 359
V F+WL FFEEDD ++KE ++G++ GE K+ LI K+ FL+EH++RR++A++
Sbjct: 306 IDVPFQWLYYFFEEDDNRIKEIEEEYRSGKMLTGELKQILIDKLNNFLEEHRRRREEAKE 365
Query: 360 QIEKFKYTGKLAQEMWDK 377
+ FKY GKLA++MW+K
Sbjct: 366 LVHVFKYDGKLAKQMWEK 383
>gi|6324475 cytoplasmic tryptophanyl-tRNA synthetase; Wrs1p [Saccharomyces
cerevisiae] >gi|2501074|sp|Q12109|SYWC_YEAST
TRYPTOPHANYL-TRNA SYNTHETASE, CYTOPLASMIC
(TRYPTOPHAN--TRNA LIGASE) (TRPRS)
>gi|1077305|pir||S51901 tryptophan--tRNA ligase (EC
6.1.1.2) [similarity] - yeast (Saccharomyces
cerevisiae) >gi|663256|emb|CAA88164.1| (Z48149)
similarity with H.sapiens tryptophanyl-tRNA synthetase
[Saccharomyces cerevisiae] >gi|1419948|emb|CAA99110.1|
(Z74839) ORF YOL097c [Saccharomyces cerevisiae]
Length = 432
Score = 344 bits (873), Expect = 1e-93
Identities = 187/392 (47%), Positives = 252/392 (63%), Gaps = 24/392 (6%)
Query: 2 VEDFKVTPWEVEGVVD---------YNKLIEHFGTSPLTEELLEKTAELTKSELPLFFRR 52
V++ VTPW+VEG VD Y+KLI+ FGT P+ EE L++ ++T E F R+
Sbjct: 22 VKEQVVTPWDVEGGVDEQGRAQNIDYDKLIKQFGTKPVNEETLKRFKQVTGREPHHFLRK 81
Query: 53 KFFFSHRDYDKVLQDYEEGRGFFLYTGRGPSGP-MHIGHIIPFFATKWLQEKFGVNLYIQ 111
FFS RD+ K+L YE+G+ FFLYTGRGPS MH+GH+IPF TKWLQE F V L I+
Sbjct: 82 GLFFSERDFTKILDLYEQGKPFFLYTGRGPSSDSMHLGHMIPFVFTKWLQEVFDVPLVIE 141
Query: 112 ITDDEKFLFKENLTFEDTKHWAYENILDIIAVGFDPDKTFIFQNSEFT--KIYEMAIPIA 169
+TDDEKFLFK LT D K++A EN DIIAVGFDP TFIF + ++ YE + ++
Sbjct: 142 LTDDEKFLFKHKLTINDVKNFARENAKDIIAVGFDPKNTFIFSDLQYMGGAFYETVVRVS 201
Query: 170 KKINFSMAKAVFGFTEQSKIGMIFFPAIQIAPTFF----------EKRRCLIPAAIDQDP 219
++I S AKAVFGF + IG F +IQIA F +K CLIP AIDQDP
Sbjct: 202 RQITGSTAKAVFGFNDSDCIGKFHFASIQIATAFPSSFPNVLGLPDKTPCLIPCAIDQDP 261
Query: 220 YWRLQRDFAESLGYYKTAAIHSKFVPSLTSLSGKMSASKPETAIYLTDSPEDVEKKVWKF 279
Y+R+ RD A+ L Y K A +HS+F P+L + KMSAS TAI++TD+P+ ++KK+ K+
Sbjct: 262 YFRVCRDVADKLKYSKPALLHSRFFPALQGSTTKMSASDDTTAIFMTDTPKQIQKKINKY 321
Query: 280 ALTGGRPTLKEQREKGGEPEKCVVFKWLEIFFEEDDKKLKERYYACKNGELTCGECKRYL 339
A +GG+ + RE GG P+ V +++L FF++DD LKE Y K+GEL GE K+
Sbjct: 322 AFSGGQVSADLHRELGGNPDVDVAYQYLS-FFKDDDVFLKECYDKYKSGELLSGEMKKLC 380
Query: 340 ISKIQEFLKEHQKRRKKA-EKQIEKFKYTGKL 370
I +QEF+K Q+RR + E+ ++KF KL
Sbjct: 381 IETLQEFVKAFQERRAQVDEETLDKFMVPHKL 412
>sp|Q09692|SYW_SCHPO PUTATIVE TRYPTOPHANYL-TRNA SYNTHETASE (TRYPTOPHAN--TRNA LIGASE)
(TRPRS) >gi|2118339|pir||S58157 hypothetical protein
SPAC2F7.13c - fission yeast (Schizosaccharomyces pombe)
>gi|1052796|emb|CAA90500.1| (Z50142) tryptophanyl-trna
synthetase, cytoplasmic [Schizosaccharomyces pombe]
Length = 395
Score = 329 bits (835), Expect = 3e-89
Identities = 177/379 (46%), Positives = 240/379 (62%), Gaps = 22/379 (5%)
Query: 2 VEDFKVTPWEVEGVV--------DYNKLIEHFGTSPLTEELLEKTAELTKSELPLFFRRK 53
VE+ VTPW+V+G + DY +LI FGT +T E LE+ +LT + L RR
Sbjct: 3 VEEQIVTPWDVKGSIVDGEEKGIDYERLIVQFGTRKITPEQLERFEKLTGKKPHLLLRRG 62
Query: 54 FFFSHRDYDKVLQDYEEGRGFFLYTGRGPSGP-MHIGHIIPFFATKWLQEKFGVNLYIQI 112
FFSHRD+D +L YE+ + F+LYTGRGPS MH+GH+IPF KWLQ+ F V L IQ+
Sbjct: 63 AFFSHRDFDMILDRYEQKKPFYLYTGRGPSSDSMHLGHMIPFMFCKWLQDVFQVPLVIQL 122
Query: 113 TDDEKFLFKENLTFEDTKHWAYENILDIIAVGFDPDKTFIFQNSEFT--KIYEMAIPIAK 170
TDDEKFLFK+ ++ ED + +A EN DIIAVGFDP KTFIF NS + Y+ + IAK
Sbjct: 123 TDDEKFLFKQGVSLEDCQRFARENAKDIIAVGFDPKKTFIFMNSTYVGGAFYQNVVRIAK 182
Query: 171 KINFSMAKAVFGFTEQSKIGMIFFPAIQIAPTF-------FEKRR---CLIPAAIDQDPY 220
I + +KA FGFT+ IG I F +IQ AP+F F + CLIP AIDQDPY
Sbjct: 183 CITANQSKACFGFTDSDSIGKIHFASIQAAPSFSSSFPHIFNGAKDIPCLIPCAIDQDPY 242
Query: 221 WRLQRDFAESLGYYKTAAIHSKFVPSLTSLSGKMSASKPETAIYLTDSPEDVEKKVWKFA 280
+RL RD + L + K A +HS+F P+L KMSASK +AI++TD+P ++ K+ + A
Sbjct: 243 FRLTRDVSGRLKFKKPALLHSRFFPALQGPQSKMSASKDSSAIFMTDTPNKIKNKINRHA 302
Query: 281 LTGGRPTLKEQREKGGEPEKCVVFKWLEIFFEEDDKKLKERYYACKNGELTCGECKRYLI 340
+GG T++ REKGG P+ V +++L FF +DD+KLK+ Y K G L+ GE K I
Sbjct: 303 FSGGGATIEIHREKGGNPDVDVAYQYLS-FFLDDDEKLKQLYNTYKAGTLSTGEMKGECI 361
Query: 341 SKIQEFLKEHQKRRKKAEK 359
+Q+F+ + Q R K ++
Sbjct: 362 KLLQQFVSDFQAARSKVDE 380
>emb|CAA44450.1| (X62570) IFP53 [Homo sapiens]
Length = 471
Score = 311 bits (789), Expect = 7e-84
Identities = 174/380 (45%), Positives = 235/380 (61%), Gaps = 22/380 (5%)
Query: 3 EDFKVTPWEVEGV----VDYNKLIEHFGTSPLTEELLEKTAELTKSELPLFFRRKFFFSH 58
EDF V PW V+ +DY+KLI FG+S + +EL+ + T F RR FFSH
Sbjct: 82 EDF-VDPWTVQTSSAKGIDYDKLIVRFGSSKIDKELINRIERATGQRPHHFLRRGIFFSH 140
Query: 59 RDYDKVLQDYEEGRGFFLYTGRGPSGP-MHIGHIIPFFATKWLQEKFGVNLYIQITDDEK 117
RD ++VL YE + F+LYTGRGPS MH+GH+IPF TKWLQ+ F V L IQ+TDDEK
Sbjct: 141 RDMNQVLDAYENKKPFYLYTGRGPSSEAMHVGHLIPFIFTKWLQDVFNVPLVIQMTDDEK 200
Query: 118 FLFKENLTFEDTKHWAYENILDIIAVGFDPDKTFIFQNSEF----TKIYEMAIPIAKKIN 173
+L+K+ LT + +A EN DIIA GFD +KTFIF + ++ + Y+ + I K +
Sbjct: 201 YLWKD-LTLDQAYSYAVENAKDIIACGFDINKTFIFSDLDYMGMSSGFYKNVVKIQKHVT 259
Query: 174 FSMAKAVFGFTEQSKIGMIFFPAIQIAPTF-------FEKR---RCLIPAAIDQDPYWRL 223
F+ K +FGFT+ IG I FPAIQ AP+F F R +CLIP AIDQDPY+R+
Sbjct: 260 FNQVKGIFGFTDSDCIGKISFPAIQAAPSFSNSFPQIFRDRTDIQCLIPCAIDQDPYFRM 319
Query: 224 QRDFAESLGYYKTAAIHSKFVPSLTSLSGKMSASKPETAIYLTDSPEDVEKKVWKFALTG 283
RD A +GY K A +HS F P+L KMSAS P ++I+LTD+ + ++ KV K A +G
Sbjct: 320 TRDVAPRIGYPKPALLHSTFFPALQGAQTKMSASDPNSSIFLTDTAKQIKTKVNKHAFSG 379
Query: 284 GRPTLKEQREKGGEPEKCVVFKWLEIFFEEDDKKLKERYYACKNGELTCGECKRYLISKI 343
GR T++E R+ GG + V F +L FF EDD KL++ +G + GE K+ LI +
Sbjct: 380 GRDTIEEHRQFGGNCDVDVSFMYL-TFFLEDDDKLEQIRKDYTSGRMLTGELKKALIEVL 438
Query: 344 QEFLKEHQKRRKKAEKQIEK 363
Q + EHQ RRK+ +I K
Sbjct: 439 QPLIAEHQARRKEVTDEIVK 458
>gi|11433596 tryptophanyl-tRNA synthetase [Homo sapiens]
>gi|135191|sp|P23381|SYW_HUMAN TRYPTOPHANYL-TRNA
SYNTHETASE (TRYPTOPHAN--TRNA LIGASE) (TRPRS) (IFP53)
>gi|107990|pir||A41706 tryptophan--tRNA ligase (EC
6.1.1.2) [similarity] - human >gi|30821|emb|CAA42545.1|
(X59892) 471 aa polypeptide (gamma2) [Homo sapiens]
>gi|184657|gb|AAA67324.1| (M77804) transfer RNA-Trp
synthetase [Homo sapiens]
Length = 471
Score = 311 bits (788), Expect = 1e-83
Identities = 174/380 (45%), Positives = 235/380 (61%), Gaps = 22/380 (5%)
Query: 3 EDFKVTPWEVEGV----VDYNKLIEHFGTSPLTEELLEKTAELTKSELPLFFRRKFFFSH 58
EDF V PW V+ +DY+KLI FG+S + +EL+ + T F RR FFSH
Sbjct: 82 EDF-VDPWTVQTSSAKGIDYDKLIVRFGSSKIDKELINRIERATGQRPHHFLRRGIFFSH 140
Query: 59 RDYDKVLQDYEEGRGFFLYTGRGPSGP-MHIGHIIPFFATKWLQEKFGVNLYIQITDDEK 117
RD ++VL YE + F+LYTGRGPS MH+GH+IPF TKWLQ+ F V L IQ+TDDEK
Sbjct: 141 RDMNQVLDAYENKKPFYLYTGRGPSSEAMHVGHLIPFIFTKWLQDVFNVPLVIQMTDDEK 200
Query: 118 FLFKENLTFEDTKHWAYENILDIIAVGFDPDKTFIFQNSEF----TKIYEMAIPIAKKIN 173
+L+K+ LT + +A EN DIIA GFD +KTFIF + ++ + Y+ + I K +
Sbjct: 201 YLWKD-LTLDQAYSYAVENAKDIIACGFDINKTFIFSDLDYMGMSSGFYKNVVKIQKHVT 259
Query: 174 FSMAKAVFGFTEQSKIGMIFFPAIQIAPTF-------FEKR---RCLIPAAIDQDPYWRL 223
F+ K +FGFT+ IG I FPAIQ AP+F F R +CLIP AIDQDPY+R+
Sbjct: 260 FNQVKGIFGFTDSDCIGKISFPAIQAAPSFSNSFPQIFRDRTDIQCLIPCAIDQDPYFRM 319
Query: 224 QRDFAESLGYYKTAAIHSKFVPSLTSLSGKMSASKPETAIYLTDSPEDVEKKVWKFALTG 283
RD A +GY K A +HS F P+L KMSAS P ++I+LTD+ + ++ KV K A +G
Sbjct: 320 TRDVAPRIGYPKPALLHSTFFPALQGAQTKMSASDPNSSIFLTDTAKQIKTKVNKHAFSG 379
Query: 284 GRPTLKEQREKGGEPEKCVVFKWLEIFFEEDDKKLKERYYACKNGELTCGECKRYLISKI 343
GR T++E R+ GG + V F +L FF EDD KL++ +G + GE K+ LI +
Sbjct: 380 GRDTIEEHRQFGGNCDVDVSFMYL-TFFLEDDDKLEQIRKDYTSGAMLTGELKKALIEVL 438
Query: 344 QEFLKEHQKRRKKAEKQIEK 363
Q + EHQ RRK+ +I K
Sbjct: 439 QPLIAEHQARRKEVTDEIVK 458
>gb|AAF20167.1|AF125157_1 (AF125157) tryptophanyl-tRNA synthetase [Drosophila melanogaster]
Length = 420
Score = 309 bits (784), Expect = 3e-83
Identities = 169/367 (46%), Positives = 225/367 (61%), Gaps = 20/367 (5%)
Query: 7 VTPWEV----EGVVDYNKLIEHFGTSPLTEELLEKTAELTKSELPLFFRRKFFFSHRDYD 62
V PW V + VDY+KLI+ FG+S + EEL+ + ++T F RR FFSHRD
Sbjct: 36 VDPWNVASSNDAGVDYDKLIKRFGSSKIDEELIARFEKITGKPAHHFIRRGMFFSHRDLH 95
Query: 63 KVLQDYEEGRGFFLYTGRGPS-GPMHIGHIIPFFATKWLQEKFGVNLYIQITDDEKFLFK 121
+L E+G+ F+LYTGRGPS G +H+GH++PF TKWLQE F V L IQ+TDDEK L+K
Sbjct: 96 TILTLREQGKPFYLYTGRGPSSGSLHVGHLVPFIMTKWLQETFDVPLVIQLTDDEKTLWK 155
Query: 122 ENLTFEDTKHWAYENILDIIAVGFDPDKTFIFQNSEFT----KIYEMAIPIAKKINFSMA 177
+ L ED EN DI+A+GFD +KTFIF N EF +Y+ I I K + F+
Sbjct: 156 D-LKVEDAIKLGRENAKDIVAIGFDVNKTFIFNNLEFVGKCPAMYQNIIRIQKCVTFNQV 214
Query: 178 KAVFGFTEQSKIGMIFFPAIQIAPTFFE---------KRRCLIPAAIDQDPYWRLQRDFA 228
K +FGF + IG I FPA Q AP K CLIP AIDQDPY+R+ RD A
Sbjct: 215 KGIFGFGDSDIIGKIGFPAAQAAPAISSTFPFIFGNRKVHCLIPCAIDQDPYFRMTRDVA 274
Query: 229 ESLGYYKTAAIHSKFVPSLTSLSGKMSASKPETAIYLTDSPEDVEKKVWKFALTGGRPTL 288
LG+ K A IHS F P+L KMSAS +A+YLTD+P+ ++ K+ K+A +GGR T+
Sbjct: 275 PRLGFPKCALIHSTFFPALQGAKTKMSASDQNSAVYLTDTPKQIKNKINKYAFSGGRVTV 334
Query: 289 KEQREKGGEPEKCVVFKWLEIFFEEDDKKLKERYYACKNGELTCGECKRYLISKIQEFLK 348
+E R+ GG PE V ++ L+ FF EDD KL+E A GE+ GE K+ + + ++
Sbjct: 335 EEHRKLGGVPEVDVSYQLLK-FFLEDDAKLEEVRVAYSKGEMLTGEIKKLAVETLTPIVE 393
Query: 349 EHQKRRK 355
+HQ RK
Sbjct: 394 QHQAARK 400
>gb|AAF20166.1|AF125156_1 (AF125156) tryptophanyl-tRNA synthetase [Drosophila melanogaster]
Length = 430
Score = 309 bits (784), Expect = 3e-83
Identities = 169/367 (46%), Positives = 225/367 (61%), Gaps = 20/367 (5%)
Query: 7 VTPWEV----EGVVDYNKLIEHFGTSPLTEELLEKTAELTKSELPLFFRRKFFFSHRDYD 62
V PW V + VDY+KLI+ FG+S + EEL+ + ++T F RR FFSHRD
Sbjct: 46 VDPWNVASSNDAGVDYDKLIKRFGSSKIDEELIARFEKITGKPAHHFIRRGMFFSHRDLH 105
Query: 63 KVLQDYEEGRGFFLYTGRGPS-GPMHIGHIIPFFATKWLQEKFGVNLYIQITDDEKFLFK 121
+L E+G+ F+LYTGRGPS G +H+GH++PF TKWLQE F V L IQ+TDDEK L+K
Sbjct: 106 TILTLREQGKPFYLYTGRGPSSGSLHVGHLVPFIMTKWLQETFDVPLVIQLTDDEKTLWK 165
Query: 122 ENLTFEDTKHWAYENILDIIAVGFDPDKTFIFQNSEFT----KIYEMAIPIAKKINFSMA 177
+ L ED EN DI+A+GFD +KTFIF N EF +Y+ I I K + F+
Sbjct: 166 D-LKVEDAIKLGRENAKDIVAIGFDVNKTFIFNNLEFVGKCPAMYQNIIRIQKCVTFNQV 224
Query: 178 KAVFGFTEQSKIGMIFFPAIQIAPTFFE---------KRRCLIPAAIDQDPYWRLQRDFA 228
K +FGF + IG I FPA Q AP K CLIP AIDQDPY+R+ RD A
Sbjct: 225 KGIFGFGDSDIIGKIGFPAAQAAPAISSTFPFIFGNRKVHCLIPCAIDQDPYFRMTRDVA 284
Query: 229 ESLGYYKTAAIHSKFVPSLTSLSGKMSASKPETAIYLTDSPEDVEKKVWKFALTGGRPTL 288
LG+ K A IHS F P+L KMSAS +A+YLTD+P+ ++ K+ K+A +GGR T+
Sbjct: 285 PRLGFPKCALIHSTFFPALQGAKTKMSASDQNSAVYLTDTPKQIKNKINKYAFSGGRVTV 344
Query: 289 KEQREKGGEPEKCVVFKWLEIFFEEDDKKLKERYYACKNGELTCGECKRYLISKIQEFLK 348
+E R+ GG PE V ++ L+ FF EDD KL+E A GE+ GE K+ + + ++
Sbjct: 345 EEHRKLGGVPEVDVSYQLLK-FFLEDDAKLEEVRVAYSKGEMLTGEIKKLAVETLTPIVE 403
Query: 349 EHQKRRK 355
+HQ RK
Sbjct: 404 QHQAARK 410
>gi|4759316 tryptophanyl-tRNA synthetase; interferon-induced protein 53 [Homo
sapiens] >gi|88944|pir||JH0533 tryptophan--tRNA ligase
(EC 6.1.1.2) - human >gi|340368|gb|AAA61298.1| (M61715)
transfer RNA-Trp synthetase [Homo sapiens]
Length = 471
Score = 308 bits (781), Expect = 6e-83
Identities = 174/380 (45%), Positives = 234/380 (60%), Gaps = 22/380 (5%)
Query: 3 EDFKVTPWEVEGV----VDYNKLIEHFGTSPLTEELLEKTAELTKSELPLFFRRKFFFSH 58
EDF V PW V+ +DY+KLI FG+S + +EL+ + T F RR FFSH
Sbjct: 82 EDF-VDPWTVQTSSAKGIDYDKLIVRFGSSKIDKELINRIERATGQRPHHFLRRGIFFSH 140
Query: 59 RDYDKVLQDYEEGRGFFLYTGRGPSGP-MHIGHIIPFFATKWLQEKFGVNLYIQITDDEK 117
RD ++VL YE + F+LYTGRGPS MH+GH+IPF TKWLQ+ F V L IQ+TDDEK
Sbjct: 141 RDMNQVLDAYENKKPFYLYTGRGPSSEAMHVGHLIPFIFTKWLQDVFNVPLVIQMTDDEK 200
Query: 118 FLFKENLTFEDTKHWAYENILDIIAVGFDPDKTFIFQNSEF----TKIYEMAIPIAKKIN 173
+L+K+ LT + A EN DIIA GFD +KTFIF + ++ + Y+ + I K +
Sbjct: 201 YLWKD-LTLDQAYGDAVENAKDIIACGFDINKTFIFSDLDYMGMSSGFYKNVVKIQKHVT 259
Query: 174 FSMAKAVFGFTEQSKIGMIFFPAIQIAPTF-------FEKR---RCLIPAAIDQDPYWRL 223
F+ K +FGFT+ IG I FPAIQ AP+F F R +CLIP AIDQDPY+R+
Sbjct: 260 FNQVKGIFGFTDSDCIGKISFPAIQAAPSFSNSFPQIFRDRTDIQCLIPCAIDQDPYFRM 319
Query: 224 QRDFAESLGYYKTAAIHSKFVPSLTSLSGKMSASKPETAIYLTDSPEDVEKKVWKFALTG 283
RD A +GY K A +HS F P+L KMSAS P ++I+LTD+ + ++ KV K A +G
Sbjct: 320 TRDVAPRIGYPKPALLHSTFFPALQGAQTKMSASDPNSSIFLTDTAKQIKTKVNKHAFSG 379
Query: 284 GRPTLKEQREKGGEPEKCVVFKWLEIFFEEDDKKLKERYYACKNGELTCGECKRYLISKI 343
GR T++E R+ GG + V F +L FF EDD KL++ +G + GE K+ LI +
Sbjct: 380 GRDTIEEHRQFGGNCDVDVSFMYL-TFFLEDDDKLEQIRKDYTSGAMLTGELKKALIEVL 438
Query: 344 QEFLKEHQKRRKKAEKQIEK 363
Q + EHQ RRK+ +I K
Sbjct: 439 QPLIAEHQARRKEVTDEIVK 458
>gb|AAF54352.1| (AE003682) Aats-trp gene product [alt 1] [Drosophila melanogaster]
>gi|10726403|gb|AAG22136.1| (AE003682) Aats-trp gene
product [alt 2] [Drosophila melanogaster]
Length = 430
Score = 308 bits (780), Expect = 8e-83
Identities = 168/367 (45%), Positives = 225/367 (60%), Gaps = 20/367 (5%)
Query: 7 VTPWEV----EGVVDYNKLIEHFGTSPLTEELLEKTAELTKSELPLFFRRKFFFSHRDYD 62
V PW V + VDY+KLI+ FG+S + EEL+ + ++T F RR FFSHRD
Sbjct: 46 VDPWNVASSNDAGVDYDKLIKRFGSSKIDEELIARFEKITGKPAHHFIRRGMFFSHRDLH 105
Query: 63 KVLQDYEEGRGFFLYTGRGPS-GPMHIGHIIPFFATKWLQEKFGVNLYIQITDDEKFLFK 121
+L E+G+ F+LYTGRGPS G +H+GH++PF TKWLQE F V L IQ+TDDEK L+K
Sbjct: 106 TILTLREQGKPFYLYTGRGPSSGSLHVGHLVPFIMTKWLQETFDVPLVIQLTDDEKTLWK 165
Query: 122 ENLTFEDTKHWAYENILDIIAVGFDPDKTFIFQNSEFT----KIYEMAIPIAKKINFSMA 177
+ L ED EN DI+A+GFD +KTFIF N EF +Y+ I I K + F+
Sbjct: 166 D-LKVEDAIKLGRENAKDIVAIGFDVNKTFIFNNLEFVGKCPAMYQNIIRIQKCVTFNQV 224
Query: 178 KAVFGFTEQSKIGMIFFPAIQIAPTFFE---------KRRCLIPAAIDQDPYWRLQRDFA 228
K +FGF + IG I FPA Q AP K CLIP AIDQDPY+R+ RD A
Sbjct: 225 KGIFGFGDSDIIGKIGFPAAQAAPAISSTFPFIFGNRKVHCLIPCAIDQDPYFRMTRDVA 284
Query: 229 ESLGYYKTAAIHSKFVPSLTSLSGKMSASKPETAIYLTDSPEDVEKKVWKFALTGGRPTL 288
LG+ K A IHS F P+L KMSAS +A+YLTD+P+ ++ K+ K+A +GGR ++
Sbjct: 285 PRLGFPKCALIHSTFFPALQGAKTKMSASDQNSAVYLTDTPKQIKNKINKYAFSGGRVSV 344
Query: 289 KEQREKGGEPEKCVVFKWLEIFFEEDDKKLKERYYACKNGELTCGECKRYLISKIQEFLK 348
+E R+ GG PE V ++ L+ FF EDD KL+E A GE+ GE K+ + + ++
Sbjct: 345 EEHRKLGGVPEVDVSYQLLK-FFLEDDAKLEEVRVAYSKGEMLTGEIKKLAVETLTPIVE 403
Query: 349 EHQKRRK 355
+HQ RK
Sbjct: 404 QHQAARK 410
>sp|P23612|SYW_RABIT TRYPTOPHANYL-TRNA SYNTHETASE (TRYPTOPHAN--TRNA LIGASE) (TRPRS)
Length = 475
Score = 304 bits (771), Expect = 1e-81
Identities = 169/380 (44%), Positives = 231/380 (60%), Gaps = 22/380 (5%)
Query: 3 EDFKVTPWEVEGV----VDYNKLIEHFGTSPLTEELLEKTAELTKSELPLFFRRKFFFSH 58
EDF V PW V +DY+KLI FG+S + +EL+ + T F RR FFSH
Sbjct: 86 EDF-VDPWTVRTSSAKGIDYDKLIVQFGSSKIDKELVNRIERATGQRPHRFLRRGIFFSH 144
Query: 59 RDYDKVLQDYEEGRGFFLYTGRGPSGP-MHIGHIIPFFATKWLQEKFGVNLYIQITDDEK 117
RD ++VL YE + F+LYTGRGPS MH+GH+IPF TKWLQ+ F V L +Q++DDEK
Sbjct: 145 RDMNQVLDAYENKKPFYLYTGRGPSSEAMHVGHLIPFIFTKWLQDVFDVPLVVQMSDDEK 204
Query: 118 FLFKENLTFEDTKHWAYENILDIIAVGFDPDKTFIFQNSEFTKI----YEMAIPIAKKIN 173
+L+K+ LT E + EN DIIA GFD +KTFIF + ++ + Y+ + I K +
Sbjct: 205 YLWKD-LTLEQVYGYTLENAKDIIACGFDVNKTFIFSDLDYMGMSPGFYKNVVKIQKHVT 263
Query: 174 FSMAKAVFGFTEQSKIGMIFFPAIQIAPTFFEKR----------RCLIPAAIDQDPYWRL 223
F+ K +FGFT+ IG I FPAIQ AP+F +CLIP AIDQDPY+R+
Sbjct: 264 FNQVKGIFGFTDSDCIGKISFPAIQAAPSFSNSFPQIFHGQADIQCLIPCAIDQDPYFRM 323
Query: 224 QRDFAESLGYYKTAAIHSKFVPSLTSLSGKMSASKPETAIYLTDSPEDVEKKVWKFALTG 283
RD A +GY K A +HS F P+L KMSAS P ++I+LTD+ + ++ KV K A +G
Sbjct: 324 TRDVAPRIGYPKPALLHSTFFPALQGAQTKMSASDPNSSIFLTDTAKQIKTKVNKHAFSG 383
Query: 284 GRPTLKEQREKGGEPEKCVVFKWLEIFFEEDDKKLKERYYACKNGELTCGECKRYLISKI 343
GR T++E R+ GG + V F +L FF EDD KL++ +G + GE K+ LI +
Sbjct: 384 GRDTIEEHRQFGGNCDVDVSFMYL-TFFLEDDDKLEQIRKDYSSGAMLTGELKKELIDVL 442
Query: 344 QEFLKEHQKRRKKAEKQIEK 363
Q + EHQ RRK+ ++ K
Sbjct: 443 QPLVAEHQARRKEVTDEMVK 462
>pir||YWRBPR tryptophan--tRNA ligase (EC 6.1.1.2) [validated] - rabbit
Length = 475
Score = 301 bits (763), Expect = 8e-81
Identities = 167/380 (43%), Positives = 230/380 (59%), Gaps = 22/380 (5%)
Query: 3 EDFKVTPWEVEGV----VDYNKLIEHFGTSPLTEELLEKTAELTKSELPLFFRRKFFFSH 58
EDF V PW V +DY+KLI FG+S + +EL+ + T F RR FFSH
Sbjct: 86 EDF-VDPWTVRTSSAKGIDYDKLIVQFGSSKIDKELVNRIERATGQRPHRFLRRGIFFSH 144
Query: 59 RDYDKVLQDYEEGRGFFLYTGRGPSGP-MHIGHIIPFFATKWLQEKFGVNLYIQITDDEK 117
RD ++VL YE + F+LYTGRGPS MH+GH+IPF TKWLQ+ F V L +Q++DDEK
Sbjct: 145 RDMNQVLDAYENKKPFYLYTGRGPSSEAMHVGHLIPFIFTKWLQDVFDVPLVVQMSDDEK 204
Query: 118 FLFKENLTFEDTKHWAYENILDIIAVGFDPDKTFIFQNSEFTKI----YEMAIPIAKKIN 173
+L+K+ LT E + EN DI+ GFD +KTFIF + ++ + Y+ + I K +
Sbjct: 205 YLWKD-LTLEQVYGYTLENAKDIMPCGFDVNKTFIFSDLDYMGMSPGFYKNVVKIQKHVT 263
Query: 174 FSMAKAVFGFTEQSKIGMIFFPAIQIAPTFFEKR----------RCLIPAAIDQDPYWRL 223
F+ K +FGFT+ IG I FPAIQ AP+F +CLIP AIDQDPY+R+
Sbjct: 264 FNQVKGIFGFTDSDCIGKISFPAIQAAPSFSNSFPQIFHGQADIQCLIPCAIDQDPYFRM 323
Query: 224 QRDFAESLGYYKTAAIHSKFVPSLTSLSGKMSASKPETAIYLTDSPEDVEKKVWKFALTG 283
RD A +GY K A +HS F P+L KMSAS P ++I+LTD+ + ++ KV K A +G
Sbjct: 324 TRDVAPRIGYPKPALLHSTFFPALQDAQTKMSASDPNSSIFLTDTAKQIKTKVNKHAFSG 383
Query: 284 GRPTLKEQREKGGEPEKCVVFKWLEIFFEEDDKKLKERYYACKNGELTCGECKRYLISKI 343
GR T++E R+ GG + V F +L FF EDD KL++ +G + GE K+ LI +
Sbjct: 384 GRDTIEEHRQFGGNCDVDVSFMYL-TFFLEDDDKLEQIRKDYSSGAMLTGELKKELIDVL 442
Query: 344 QEFLKEHQKRRKKAEKQIEK 363
Q + EHQ RRK+ ++ K
Sbjct: 443 QPLVAEHQARRKEVTDEMVK 462
>sp|P17248|SYW_BOVIN TRYPTOPHANYL-TRNA SYNTHETASE (TRYPTOPHAN--TRNA LIGASE) (TRPRS)
>gi|68509|pir||YWBO tryptophan--tRNA ligase (EC 6.1.1.2)
[validated] - bovine >gi|825|emb|CAA37872.1| (X53918)
tryptophan-tRNA ligase [Bos taurus]
>gi|163799|gb|AAA30799.1| (M74074) transfer RNA-Trp
synthetase [Bos taurus]
Length = 475
Score = 301 bits (762), Expect = 1e-80
Identities = 171/380 (45%), Positives = 232/380 (61%), Gaps = 23/380 (6%)
Query: 3 EDFKVTPWEVEGV----VDYNKLIEHFGTSPLTEELLEKTAELTKSELPLFFRRKFFFSH 58
EDF V PW V+ +DY+KLI FG+S + +EL+ + T F RR FFSH
Sbjct: 87 EDF-VDPWTVQTSSAKGIDYDKLIVRFGSSKIDKELVNRIERATGQRPHRFLRRGIFFSH 145
Query: 59 RDYDKVLQDYEEGRGFFLYTGRGPSGP-MHIGHIIPFFATKWLQEKFGVNLYIQITDDEK 117
RD ++L YE + F+LYTGRGPS MH+GH+IPF TKWLQ+ F V L IQ+TDDEK
Sbjct: 146 RDMHQILDAYENKKPFYLYTGRGPSSEAMHVGHLIPFIFTKWLQDVFNVPLVIQMTDDEK 205
Query: 118 FLFKENLTFEDTKHWAYENILDIIAVGFDPDKTFIFQNSEFTKI----YEMAIPIAKKIN 173
+L+K+ LT + +A EN DI GFD +KTFIF + ++ + Y+ + I K +
Sbjct: 206 YLWKD-LTLDQAYGYAVENAKDITC-GFDINKTFIFSDLDYMGMSPGFYKNVVKIQKHVT 263
Query: 174 FSMAKAVFGFTEQSKIGMIFFPAIQIAPTF-------FEKR---RCLIPAAIDQDPYWRL 223
F+ K +FGFT+ IG I FPAIQ AP+F F R +CLIP AIDQDPY+R+
Sbjct: 264 FNQVKGIFGFTDSDCIGKISFPAIQAAPSFSNSFPQIFRDRTDVQCLIPCAIDQDPYFRM 323
Query: 224 QRDFAESLGYYKTAAIHSKFVPSLTSLSGKMSASKPETAIYLTDSPEDVEKKVWKFALTG 283
RD A +GY K A +HS F P+L KMSAS P ++I+LTD+ + ++ KV K A +G
Sbjct: 324 TRDVAPRIGYPKPALLHSTFFPALQGAQTKMSASDPNSSIFLTDTAKQIKTKVNKHAFSG 383
Query: 284 GRPTLKEQREKGGEPEKCVVFKWLEIFFEEDDKKLKERYYACKNGELTCGECKRYLISKI 343
GR T++E R+ GG + V F +L FF EDD KL++ +G + GE K+ LI +
Sbjct: 384 GRDTVEEHRQFGGNCDVDVSFMYL-TFFLEDDDKLEQIRRDYTSGAMLTGELKKELIEVL 442
Query: 344 QEFLKEHQKRRKKAEKQIEK 363
Q + EHQ RRK+ +I K
Sbjct: 443 QPLIAEHQARRKEVTDEIVK 462
>emb|CAA36356.1| (X52113) tryptophan tRNA ligase (AA 1-459) [Bos taurus]
Length = 459
Score = 301 bits (762), Expect = 1e-80
Identities = 171/380 (45%), Positives = 232/380 (61%), Gaps = 23/380 (6%)
Query: 3 EDFKVTPWEVEGV----VDYNKLIEHFGTSPLTEELLEKTAELTKSELPLFFRRKFFFSH 58
EDF V PW V+ +DY+KLI FG+S + +EL+ + T F RR FFSH
Sbjct: 71 EDF-VDPWTVQTSSAKGIDYDKLIVRFGSSKIDKELVNRIERATGQRPHRFLRRGIFFSH 129
Query: 59 RDYDKVLQDYEEGRGFFLYTGRGPSGP-MHIGHIIPFFATKWLQEKFGVNLYIQITDDEK 117
RD ++L YE + F+LYTGRGPS MH+GH+IPF TKWLQ+ F V L IQ+TDDEK
Sbjct: 130 RDMHQILDAYENKKPFYLYTGRGPSSEAMHVGHLIPFIFTKWLQDVFNVPLVIQMTDDEK 189
Query: 118 FLFKENLTFEDTKHWAYENILDIIAVGFDPDKTFIFQNSEFTKI----YEMAIPIAKKIN 173
+L+K+ LT + +A EN DI GFD +KTFIF + ++ + Y+ + I K +
Sbjct: 190 YLWKD-LTLDQAYGYAVENAKDITC-GFDINKTFIFSDLDYMGMSPGFYKNVVKIQKHVT 247
Query: 174 FSMAKAVFGFTEQSKIGMIFFPAIQIAPTF-------FEKR---RCLIPAAIDQDPYWRL 223
F+ K +FGFT+ IG I FPAIQ AP+F F R +CLIP AIDQDPY+R+
Sbjct: 248 FNQVKGIFGFTDSDCIGKISFPAIQAAPSFSNSFPQIFRDRTDVQCLIPCAIDQDPYFRM 307
Query: 224 QRDFAESLGYYKTAAIHSKFVPSLTSLSGKMSASKPETAIYLTDSPEDVEKKVWKFALTG 283
RD A +GY K A +HS F P+L KMSAS P ++I+LTD+ + ++ KV K A +G
Sbjct: 308 TRDVAPRIGYPKPALLHSTFFPALQGAQTKMSASDPNSSIFLTDTAKQIKTKVNKHAFSG 367
Query: 284 GRPTLKEQREKGGEPEKCVVFKWLEIFFEEDDKKLKERYYACKNGELTCGECKRYLISKI 343
GR T++E R+ GG + V F +L FF EDD KL++ +G + GE K+ LI +
Sbjct: 368 GRDTVEEHRQFGGNCDVDVSFMYL-TFFLEDDDKLEQIRRDYTSGAMLTGELKKELIEVL 426
Query: 344 QEFLKEHQKRRKKAEKQIEK 363
Q + EHQ RRK+ +I K
Sbjct: 427 QPLIAEHQARRKEVTDEIVK 446
>emb|CAA49347.1| (X69656) tryptophan--tRNA ligase [Mus musculus]
Length = 475
Score = 296 bits (749), Expect = 4e-79
Identities = 166/380 (43%), Positives = 228/380 (59%), Gaps = 22/380 (5%)
Query: 3 EDFKVTPWEVEGV----VDYNKLIEHFGTSPLTEELLEKTAELTKSELPLFFRRKFFFSH 58
EDF V PW V +DY+KLI G+S + +EL+ + T F RR FFSH
Sbjct: 86 EDF-VDPWTVRTSSAKGIDYDKLIVQPGSSKIDKELINRIERATGQRPHRFLRRGIFFSH 144
Query: 59 RDYDKVLQDYEEGRGFFLYTGRGPSGP-MHIGHIIPFFATKWLQEKFGVNLYIQITDDEK 117
RD +++L YE + F+LYTGRGPS MH+GH++PF TKWL++ F V L IQ++DDEK
Sbjct: 145 RDMNQILDAYENKKPFYLYTGRGPSSEAMHLGHLVPFIFTKWLEDVFNVPLVIQMSDDEK 204
Query: 118 FLFKENLTFEDTKHWAYENILDIIAVGFDPDKTFIFQNSEFTK----IYEMAIPIAKKIN 173
+L+K+ LT E + EN DIIA GFD +KTFIF + E+ Y + I K +
Sbjct: 205 YLWKD-LTLEQAYSYTVENAKDIIACGFDINKTFIFSDLEYMGQSPGFYRNVVKIQKHVT 263
Query: 174 FSMAKAVFGFTEQSKIGMIFFPAIQIAPTF-------FEKR---RCLIPAAIDQDPYWRL 223
F+ K +FGFT+ IG FPA+Q AP+F F R +CLIP AIDQDPY+R+
Sbjct: 264 FNQVKGIFGFTDSDCIGKSSFPAVQAAPSFSNSFPKIFRDRTDIQCLIPCAIDQDPYFRM 323
Query: 224 QRDFAESLGYYKTAAIHSKFVPSLTSLSGKMSASKPETAIYLTDSPEDVEKKVWKFALTG 283
RD A +G+ K A +HS F P+L KMSAS P ++I+LTD+ + ++ KV K A +G
Sbjct: 324 TRDVAPRIGHPKPALLHSTFFPALQGAQTKMSASDPNSSIFLTDTAKQIKSKVNKHAFSG 383
Query: 284 GRPTLKEQREKGGEPEKCVVFKWLEIFFEEDDKKLKERYYACKNGELTCGECKRYLISKI 343
GR T++E R+ GG E V F +L FF EDD +L++ +G + GE K+ LI +
Sbjct: 384 GRDTVEEHRQFGGNCEVDVSFMYL-TFFLEDDDRLEQIRKDYTSGAMLTGELKKTLIDVL 442
Query: 344 QEFLKEHQKRRKKAEKQIEK 363
Q + EHQ RRK ++ K
Sbjct: 443 QPLIAEHQARRKAVTEETVK 462
>gi|6755991 tryptophanyl-tRNA synthetase [Mus musculus]
>gi|417846|sp|P32921|SYW_MOUSE TRYPTOPHANYL-TRNA
SYNTHETASE (TRYPTOPHAN--TRNA LIGASE) (TRPRS)
>gi|1085542|pir||S50053 tryptophan--tRNA ligase (EC
6.1.1.2) alpha-2 chain - mouse >gi|55438|emb|CAA49348.1|
(X69657) tryptophan--tRNA ligase [Mus musculus]
Length = 481
Score = 296 bits (749), Expect = 4e-79
Identities = 166/380 (43%), Positives = 228/380 (59%), Gaps = 22/380 (5%)
Query: 3 EDFKVTPWEVEGV----VDYNKLIEHFGTSPLTEELLEKTAELTKSELPLFFRRKFFFSH 58
EDF V PW V +DY+KLI G+S + +EL+ + T F RR FFSH
Sbjct: 86 EDF-VDPWTVRTSSAKGIDYDKLIVQPGSSKIDKELINRIERATGQRPHRFLRRGIFFSH 144
Query: 59 RDYDKVLQDYEEGRGFFLYTGRGPSGP-MHIGHIIPFFATKWLQEKFGVNLYIQITDDEK 117
RD +++L YE + F+LYTGRGPS MH+GH++PF TKWL++ F V L IQ++DDEK
Sbjct: 145 RDMNQILDAYENKKPFYLYTGRGPSSEAMHLGHLVPFIFTKWLEDVFNVPLVIQMSDDEK 204
Query: 118 FLFKENLTFEDTKHWAYENILDIIAVGFDPDKTFIFQNSEFTK----IYEMAIPIAKKIN 173
+L+K+ LT E + EN DIIA GFD +KTFIF + E+ Y + I K +
Sbjct: 205 YLWKD-LTLEQAYSYTVENAKDIIACGFDINKTFIFSDLEYMGQSPGFYRNVVKIQKHVT 263
Query: 174 FSMAKAVFGFTEQSKIGMIFFPAIQIAPTF-------FEKR---RCLIPAAIDQDPYWRL 223
F+ K +FGFT+ IG FPA+Q AP+F F R +CLIP AIDQDPY+R+
Sbjct: 264 FNQVKGIFGFTDSDCIGKSSFPAVQAAPSFSNSFPKIFRDRTDIQCLIPCAIDQDPYFRM 323
Query: 224 QRDFAESLGYYKTAAIHSKFVPSLTSLSGKMSASKPETAIYLTDSPEDVEKKVWKFALTG 283
RD A +G+ K A +HS F P+L KMSAS P ++I+LTD+ + ++ KV K A +G
Sbjct: 324 TRDVAPRIGHPKPALLHSTFFPALQGAQTKMSASDPNSSIFLTDTAKQIKSKVNKHAFSG 383
Query: 284 GRPTLKEQREKGGEPEKCVVFKWLEIFFEEDDKKLKERYYACKNGELTCGECKRYLISKI 343
GR T++E R+ GG E V F +L FF EDD +L++ +G + GE K+ LI +
Sbjct: 384 GRDTVEEHRQFGGNCEVDVSFMYL-TFFLEDDDRLEQIRKDYTSGAMLTGELKKTLIDVL 442
Query: 344 QEFLKEHQKRRKKAEKQIEK 363
Q + EHQ RRK ++ K
Sbjct: 443 QPLIAEHQARRKAVTEETVK 462
>gb|AAA31246.1| (M33460) eucaryotic release factor (eRF) [Oryctolagus cuniculus]
Length = 475
Score = 293 bits (742), Expect = 2e-78
Identities = 164/380 (43%), Positives = 228/380 (59%), Gaps = 22/380 (5%)
Query: 3 EDFKVTPWEVEGV----VDYNKLIEHFGTSPLTEELLEKTAELTKSELPLFFRRKFFFSH 58
EDF V PW V +DY+KLI FG+S + +EL+ + T F RR FFSH
Sbjct: 86 EDF-VDPWTVRTSSAKGIDYDKLIVQFGSSKIDKELVNRIERATGQRPHRFLRRGIFFSH 144
Query: 59 RDYDKVLQDYEEGRGFFLYTGRGPS-GPMHIGHIIPFFATKWLQEKFGVNLYIQITDDEK 117
RD ++VL YE + F+LYTGRGP ++GH+IPF TKWLQ+ F V L +Q++DDEK
Sbjct: 145 RDMNQVLDAYENKKPFYLYTGRGPLLKQCNVGHLIPFIFTKWLQDVFDVPLVVQMSDDEK 204
Query: 118 FLFKENLTFEDTKHWAYENILDIIAVGFDPDKTFIFQNSEFTKI----YEMAIPIAKKIN 173
+L+K+ LT E + EN DI+ GFD +KTFIF + ++ + Y+ + I K +
Sbjct: 205 YLWKD-LTLEQVYGYTLENAKDIMPCGFDVNKTFIFSDLDYMGMSPGFYKNVVKIQKHVT 263
Query: 174 FSMAKAVFGFTEQSKIGMIFFPAIQIAPTFFEKR----------RCLIPAAIDQDPYWRL 223
F+ K +FGFT+ IG I FPAIQ AP+F +CLIP AIDQDPY+R+
Sbjct: 264 FNQVKGIFGFTDSDCIGKISFPAIQAAPSFSNSFPQIFHGQADIQCLIPCAIDQDPYFRM 323
Query: 224 QRDFAESLGYYKTAAIHSKFVPSLTSLSGKMSASKPETAIYLTDSPEDVEKKVWKFALTG 283
RD A +GY K A +HS F P+L KMSAS P ++I+LTD+ + ++ KV K A +G
Sbjct: 324 TRDVAPRIGYPKPALLHSTFFPALQGAQTKMSASDPNSSIFLTDTAKQIKTKVNKHAFSG 383
Query: 284 GRPTLKEQREKGGEPEKCVVFKWLEIFFEEDDKKLKERYYACKNGELTCGECKRYLISKI 343
GR T++E R+ GG + V F +L FF EDD KL++ +G + GE K+ LI +
Sbjct: 384 GRDTIEEHRQFGGNCDVDVSFMYL-TFFLEDDDKLEQIRKDYSSGAMLTGELKKELIDVL 442
Query: 344 QEFLKEHQKRRKKAEKQIEK 363
Q + EHQ RRK+ ++ K
Sbjct: 443 QPLVAEHQARRKEVTDEMVK 462
>gb|AAF04890.1|AC011437_5 (AC011437) putative tryptophanyl-tRNA synthetase [Arabidopsis
thaliana]
Length = 402
Score = 293 bits (741), Expect = 3e-78
Identities = 155/365 (42%), Positives = 224/365 (60%), Gaps = 19/365 (5%)
Query: 7 VTPWEVE----GVVDYNKLIEHFGTSPLTEELLEKTAELTKSELPLFFRRKFFFSHRDYD 62
V PWEV G +DY+KLI+ FG L E L+++ LT + +F RR FF+HRD++
Sbjct: 18 VNPWEVSAKDGGKIDYDKLIDKFGCQRLDESLIDRVQRLTSRQPHVFLRRSVFFAHRDFN 77
Query: 63 KVLQDYEEGRGFFLYTGRGPSGP-MHIGHIIPFFATKWLQEKFGVNLYIQITDDEKFLFK 121
++L YE G F+LYTGRGPS +H+GH+IPF TK+LQE F V L IQ+TDDEK ++K
Sbjct: 78 EILDAYERGDKFYLYTGRGPSSEALHLGHLIPFMFTKYLQEAFKVPLVIQLTDDEKSIWK 137
Query: 122 ENLTFEDTKHWAYENILDIIAVGFDPDKTFIFQNSEFT--KIYEMAIPIAKKINFSMAKA 179
NL+ E+++ A EN DIIA GFD KTFIF + ++ Y+ + + K + + A
Sbjct: 138 -NLSVEESQRLARENAKDIIACGFDVTKTFIFSDFDYVGGAFYKNMVKVGKCVTLNKAMG 196
Query: 180 VFGFTEQSKIGMIFFPAIQIAPTF----------FEKRRCLIPAAIDQDPYWRLQRDFAE 229
+FGF+ + I + FP +Q P+F + RCLIP AIDQDPY+R+ RD A
Sbjct: 197 IFGFSGEDPIAKLSFPPVQAVPSFPSSFPHLFPGKDNLRCLIPCAIDQDPYFRMTRDVAP 256
Query: 230 SLGYYKTAAIHSKFVPSLTSLSGKMSASKPETAIYLTDSPEDVEKKVWKFALTGGRPTLK 289
LGY K A I S F P+L +GKMSAS P +AIY+TDS +D++ K+ ++A +GG+ +++
Sbjct: 257 RLGYSKPALIESTFFPALQGENGKMSASDPNSAIYVTDSAKDIKNKINRYAFSGGQDSIE 316
Query: 290 EQREKGGEPEKCVVFKWLEIFFEEDDKKLKERYYACKNGELTCGECKRYLISKIQEFLKE 349
+ RE G E + K+L FF EDD +L+ G + GE K+ L + E ++
Sbjct: 317 KHRELGANLEVDIPVKYLS-FFLEDDSELEHIKKEYGEGRMLTGEVKKRLTEVLTEIVER 375
Query: 350 HQKRR 354
H++ R
Sbjct: 376 HRRAR 380
>sp|Q58810|SYW_METJA TRYPTOPHANYL-TRNA SYNTHETASE (TRYPTOPHAN--TRNA LIGASE) (TRPRS)
>gi|2129332|pir||F64476 tryptophan--tRNA ligase (EC
6.1.1.2) - Methanococcus jannaschii
>gi|1592065|gb|AAB99425.1| (U67582) tryptophanyl-tRNA
synthetase (trpS) [Methanococcus jannaschii]
Length = 370
Score = 250 bits (631), Expect = 3e-65
Identities = 137/365 (37%), Positives = 217/365 (58%), Gaps = 20/365 (5%)
Query: 6 KVTPWEVEGVVDYNKLIEHFGTSPLTEELLEKTAELTKSELPLFFRRKFFFSHRDYDKVL 65
++TPWE V+DY K +E FG P+ + L + E FFRR HRD+++++
Sbjct: 5 ELTPWETPAVIDYKKTMEQFGVKPIVDVLGDLKEEHH------FFRRNIILGHRDFERIV 58
Query: 66 QDYEEGRGFFLYTGRGPSGPMHIGHIIPFFATKWLQEKFGVNLYIQITDDEKFLFKENLT 125
+ + F + +G PSG MH GH + K+ Q K+ N+ I I D E + + N++
Sbjct: 59 DAIKNNKEFAVVSGMMPSGKMHFGHKMVVDLLKFYQ-KYTDNINIPIADLEAY-WARNMS 116
Query: 126 FEDTKHWAY-ENILDIIAVGFDPDKTFIFQNSEFTKIYEMAIPIAKKINFSMAKAVFGFT 184
FE TK A E I + IA+G DP+K ++ S++ K+ ++A+ ++K+ N+S KA++GF
Sbjct: 117 FETTKELALNEYITNYIALGLDPEKINVYLQSKYQKVKDLALILSKRTNWSEMKAIYGFK 176
Query: 185 EQSKIGMIFFPAIQIAPTFF---------EKRRCLIPAAIDQDPYWRLQRDFAESLGYYK 235
++ IG +F P +Q+A E + ++P IDQDP+ RL RD A +K
Sbjct: 177 GETNIGHVFAPIVQVADILHPQLDENLSPEPKPVVVPVGIDQDPHIRLTRDIANRAKEFK 236
Query: 236 TAAIHSKFVPSLTSL-SGKMSASKPETAIYLTDSPEDVEKKVWKFALTGGRPTLKEQREK 294
S + +T L GKMS+SKPETAI+LTD + V+KK++ A TGGR TL+E ++
Sbjct: 237 FIPPSSTYHRFMTGLLGGKMSSSKPETAIFLTDDEKTVKKKIFS-AKTGGRETLEEHKKY 295
Query: 295 GGEPEKCVVFKWLEIFFEEDDKKLKERYYACKNGELTCGECKRYLISKIQEFLKEHQKRR 354
GG PE+CVV++ DDK+L E Y C++GELTCG+CK+ ++ EFLK+ +++R
Sbjct: 296 GGVPEECVVYELFLYHLILDDKELAEIYQKCRSGELTCGKCKKMAYERVVEFLKDLKEKR 355
Query: 355 KKAEK 359
++A++
Sbjct: 356 EQAKE 360
>emb|CAB60439.1| (AL132853) contains similarity to Pfam domain: PF00579 (tRNA
synthetases class I (W and Y)), Score=80.5,
E-value=1.1e-20, N=1~cDNA EST yk535h8.5 comes from this
gene [Caenorhabditis elegans]
Length = 324
Score = 249 bits (629), Expect = 4e-65
Identities = 134/291 (46%), Positives = 184/291 (63%), Gaps = 18/291 (6%)
Query: 3 EDFKVTPWEVEGV----VDYNKLIEHFGTSPLTEELLEKTAELTKSELPLFFRRKFFFSH 58
E+ +VTPWEV +DY+KLI FG L EE++ + +T + RR FF+H
Sbjct: 30 EEDRVTPWEVTTTKATGIDYDKLIVKFGCRKLDEEIIARFERVTGHKASPMLRRGMFFAH 89
Query: 59 RDYDKVLQDYEEGRGFFLYTGRGPS-GPMHIGHIIPFFATKWLQEKFGVNLYIQITDDEK 117
RD +L E+G+ F+LYTGRG S G +H+GH++PF TKWLQE F V L IQ+TDDEK
Sbjct: 90 RDLTAILDRKEQGKPFYLYTGRGASSGSLHLGHLVPFIFTKWLQEVFDVPLVIQMTDDEK 149
Query: 118 FLFKENLTFEDTKHWAYENILDIIAVGFDPDKTFIFQNSEFT--KIYEMAIPIAKKINFS 175
FL+K+ + ++ K A EN+ DII+VGFDP KTFIF N ++ YE + I K +N +
Sbjct: 150 FLWKD-MKVDEAKKMARENMKDIISVGFDPTKTFIFNNFDYMCPPFYENIVKIWKVVNTN 208
Query: 176 MAKAVFGFTEQSKIGMIFFPAIQIAPTF-------FEKRR---CLIPAAIDQDPYWRLQR 225
A+A+FGFT + +G FPA++ AP F F KR CLIP AIDQDP++R+ R
Sbjct: 209 QARAIFGFTPEDCLGKAAFPAVEAAPCFASSFPQIFGKRNDIPCLIPCAIDQDPFFRMTR 268
Query: 226 DFAESLGYYKTAAIHSKFVPSLTSLSGKMSASKPETAIYLTDSPEDVEKKV 276
D A L K + I S F+P+LT KMSAS+P T I+L+D+ + ++ KV
Sbjct: 269 DVAPRLKASKPSLIFSTFLPALTGAQTKMSASEPNTCIFLSDTAKQIKNKV 319
>dbj|BAA25288.1| (AB012222) tryptophan-tRNA synthetase [Cavia porcellus]
Length = 305
Score = 241 bits (609), Expect = 1e-62
Identities = 131/292 (44%), Positives = 182/292 (61%), Gaps = 16/292 (5%)
Query: 86 MHIGHIIPFFATKWLQEKFGVNLYIQITDDEKFLFKENLTFEDTKHWAYENILDIIAVGF 145
MH+GH+IPF TKWLQ+ F V L +Q++DDEK+L+K+ LT E + EN DIIA GF
Sbjct: 3 MHVGHLIPFIFTKWLQDVFNVPLVVQMSDDEKYLWKD-LTLEQAYGYTLENAKDIIACGF 61
Query: 146 DPDKTFIFQNSEFTKI----YEMAIPIAKKINFSMAKAVFGFTEQSKIGMIFFPAIQIAP 201
D +KTFIF + E+ + Y+ + I K + F+ K +FGFT+ IG I FPA+Q AP
Sbjct: 62 DINKTFIFSDLEYMGMSPGFYKNVVKIQKHVTFNQVKGIFGFTDSDCIGKISFPAVQAAP 121
Query: 202 TF-------FEKR---RCLIPAAIDQDPYWRLQRDFAESLGYYKTAAIHSKFVPSLTSLS 251
+F F R +CLIP AIDQDPY+R+ RD A +GY K A +HS F P+L
Sbjct: 122 SFSNSFPQIFRDRTDIQCLIPCAIDQDPYFRMTRDVAPRIGYPKPALLHSTFFPALQGAQ 181
Query: 252 GKMSASKPETAIYLTDSPEDVEKKVWKFALTGGRPTLKEQREKGGEPEKCVVFKWLEIFF 311
KMSAS P ++I+LTDS + ++ KV K A +GGR T++E R+ GG + V F +L FF
Sbjct: 182 TKMSASDPNSSIFLTDSAKQIKTKVNKHAFSGGRDTVEEHRQFGGNCDVDVSFMYL-TFF 240
Query: 312 EEDDKKLKERYYACKNGELTCGECKRYLISKIQEFLKEHQKRRKKAEKQIEK 363
EDD +L++ +G + GE K+ LI +Q + EHQ RRK+ ++ K
Sbjct: 241 LEDDDRLEQIRKDYTSGAMLTGELKKTLIDVLQPLIAEHQARRKEVTDEMVK 292
>emb|CAB94199.1| (X67923) tryptophanyl-tRNA synthetase [Homo sapiens]
Length = 290
Score = 223 bits (562), Expect = 3e-57
Identities = 125/279 (44%), Positives = 172/279 (60%), Gaps = 16/279 (5%)
Query: 99 WLQEKFGVNLYIQITDDEKFLFKENLTFEDTKHWAYENILDIIAVGFDPDKTFIFQNSEF 158
WLQ+ F V L IQ+TDDEK+L+K+ LT + +A EN DIIA GFD +KTFIF + ++
Sbjct: 1 WLQDVFNVPLVIQMTDDEKYLWKD-LTLDQAYSYAVENAKDIIACGFDINKTFIFSDLDY 59
Query: 159 ----TKIYEMAIPIAKKINFSMAKAVFGFTEQSKIGMIFFPAIQIAPTF-------FEKR 207
+ Y+ + I K + F+ K +FGFT+ IG I FPAIQ AP+F F R
Sbjct: 60 MGMSSGFYKNVVKIQKHVTFNQVKGIFGFTDSDCIGKISFPAIQAAPSFSNSFPQIFRDR 119
Query: 208 ---RCLIPAAIDQDPYWRLQRDFAESLGYYKTAAIHSKFVPSLTSLSGKMSASKPETAIY 264
+CLIP AIDQDPY+R+ RD A +GY K A +HS F P+L KMSAS P ++I+
Sbjct: 120 TDIQCLIPCAIDQDPYFRMTRDVAPRIGYPKPALLHSTFFPALQGAQTKMSASDPNSSIF 179
Query: 265 LTDSPEDVEKKVWKFALTGGRPTLKEQREKGGEPEKCVVFKWLEIFFEEDDKKLKERYYA 324
LTD+ + ++ KV K A +GGR T++E R+ GG + V F +L FF EDD KL++
Sbjct: 180 LTDTAKQIKTKVNKHAFSGGRDTIEEHRQFGGNCDVDVSFMYL-TFFLEDDDKLEQIRKD 238
Query: 325 CKNGELTCGECKRYLISKIQEFLKEHQKRRKKAEKQIEK 363
+G + GE K+ LI +Q + EHQ RRK+ +I K
Sbjct: 239 YTSGAMLTGELKKALIEVLQPLIAEHQARRKEVTDEIVK 277
>sp|O26352|SYW_METTH TRYPTOPHANYL-TRNA SYNTHETASE (TRYPTOPHAN--TRNA LIGASE) (TRPRS)
>gi|7437516|pir||E69131 tryptophan--tRNA ligase (EC
6.1.1.2) - Methanobacterium thermoautotrophicum (strain
Delta H) >gi|2621301|gb|AAB84757.1| (AE000812)
tryptophanyl-tRNA synthetase [Methanobacterium
thermoautotrophicum]
Length = 364
Score = 220 bits (555), Expect = 2e-56
Identities = 128/365 (35%), Positives = 205/365 (56%), Gaps = 26/365 (7%)
Query: 7 VTPWEVEGVVDYNKLIEHFGTSPLTEELLEKTAELTKSELPLFFRRKFFFSHRDYDKVLQ 66
+ PW ++Y LIE+FG P +E L E E RR F HRDY++++
Sbjct: 2 IDPWG-SAKLEYQDLIENFGVRPFSEVLDEVP------EPSWLMRRGIIFGHRDYERIIS 54
Query: 67 DYEEGRGFFLYTGRGPSGPMHIGHIIPFFATKWLQEKFGVNLYIQITDDEKFLFKENLTF 126
++G F + TG PSG MHIGH + +W ++ G ++I I D E + + + F
Sbjct: 55 AMKKGEDFAVVTGMMPSGRMHIGHKMIVDQLRWY-DRMGAEIFIPIADMEAYSAR-GVDF 112
Query: 127 EDTKHWAYEN-ILDIIAVGFD--PDKTFIFQNSEFTKIYEMAIPIAKKINFSMAKAVFGF 183
ED++ A E I IA+G D D ++ SE + ++A +A K+NF+ +A++GF
Sbjct: 113 EDSRRIAIEEYIAGYIALGLDLEKDNIHVYLQSENLMVEDLAYVLAGKVNFNELRAIYGF 172
Query: 184 TEQSKIGMIFFPAIQIAPTFFEK-------RRCLIPAAIDQDPYWRLQRD----FAESLG 232
T + + ++ P IQ++ + R ++P DQDP+ RL RD F + G
Sbjct: 173 TGSTSMAHMYAPIIQVSDILHPQLDELGGPRPVIVPVGPDQDPHIRLTRDIAARFRDRYG 232
Query: 233 YYKTAAIHSKFVPSLTSLSGKMSASKPETAIYLTDSPEDVEKKVWKFALTGGRPTLKEQR 292
+ ++ + +F+ LT GKMS+++P++AI+L+D+PE+ E K+ + A TGGR TLKEQR
Sbjct: 233 FILPSSTYHRFMGGLTG--GKMSSNRPKSAIFLSDTPEEAEAKI-RNAKTGGRETLKEQR 289
Query: 293 EKGGEPEKCVVFKWLEIFFEEDDKKLKERYYACKNGELTCGECKRYLISKIQEFLKEHQK 352
E GG PE+C++++ L D +L+E Y +C+NG L CGECK I++F +E
Sbjct: 290 ELGGVPEECIIYETLLYHMSGSDSRLEEIYESCRNGTLMCGECKNNTAEFIRKFFEELSV 349
Query: 353 RRKKA 357
+R+KA
Sbjct: 350 KREKA 354
>gb|AAG20355.1| (AE005109) tryptophanyl-tRNA synthetase; TrpS2 [Halobacterium sp.
NRC-1]
Length = 380
Score = 210 bits (528), Expect = 3e-53
Identities = 133/357 (37%), Positives = 196/357 (54%), Gaps = 24/357 (6%)
Query: 7 VTPWEVEGV-VDYNKLIEHFGTSPLTEELLEKTAELTKSELPLFFRRKFFFSHRDYDKVL 65
VTP+ VE +DY KL+ FG LT++ + + PL R F++ RD D L
Sbjct: 8 VTPYAVESDDLDYEKLLARFGADELTDDQRARFPDH-----PLV-NRGLFYAGRDVDDFL 61
Query: 66 QDYEEGRGFFLYTGRGPSGPMHIGHIIPFFATKWLQEKFGVNLYIQITDDEKFLFKENLT 125
E+ + TG GPSGPMH+GH + F+ + LQ++FG +Y+ ++DDEK+ FK+ T
Sbjct: 62 TAGEQS----IVTGVGPSGPMHLGHAMVFYFARRLQDEFGARVYVPLSDDEKYWFKDQ-T 116
Query: 126 FEDTKHWAYENILDIIAVGFDPDKT-FIFQNSEFTKIYEMAIPIAKKINFSMAKAVFGFT 184
+T + N+ D++AVGFDP+ T + + +Y +A A + + + V+G
Sbjct: 117 PAETGDYLRANLRDLLAVGFDPELTRIVVDTRDADVLYPLATAFAGDVRHATLQNVYG-- 174
Query: 185 EQSKIGMIFFPAIQIAPTFFEK-----RRCLIPAAIDQDPYWRLQRDFAESLGYY--KTA 237
E +G F+PA+Q A + L+P A+DQDP+ R+ RD A Y K
Sbjct: 175 EPDNVGQAFYPAVQTAHLLLPQLVHGEHETLVPIAVDQDPHVRVSRDVAAKARYPVGKPG 234
Query: 238 AIHSKFVPSLTSLSGKMSASKPETAIYLTDSPEDVEKKVWKFALTGGRPTLKEQREKGGE 297
A+ +F+PSL GKMS+S +I LTDSP+ V +KV A TGGR +++E R KGG
Sbjct: 235 ALLMQFLPSLAG-PGKMSSSAG-VSIRLTDSPDTVREKVRTHAYTGGRASVEEHRAKGGV 292
Query: 298 PEKCVVFKWLEIFFEEDDKKLKERYYACKNGELTCGECKRYLISKIQEFLKEHQKRR 354
P + V F++L FFE DD +L + G+L GE K +I EFL HQ+RR
Sbjct: 293 PAEDVPFQYLSAFFEPDDAELARIEREYRAGDLLSGELKDLAADRITEFLAAHQRRR 349
>emb|CAB58393.1| (AL121862) tryptophanyl-tRNA synthetase [Leishmania major]
Length = 490
Score = 199 bits (501), Expect = 4e-50
Identities = 131/328 (39%), Positives = 178/328 (53%), Gaps = 25/328 (7%)
Query: 49 FFRRKFFFSHRDYDKVLQDYEEG-----RGFFLYTGRGPS-GPMHIGHIIPFFATKWLQE 102
FF R FSHRD K L D E R FLYTGRGPS G MH+GH++PF TK+LQ+
Sbjct: 147 FFHRDIAFSHRDLHKALVDIEASVKTGERSVFLYTGRGPSAGTMHLGHVLPFMLTKYLQD 206
Query: 103 KFGVNLYIQITDDEKFLFKENLTFEDTK--HWAYENILDIIAVGFDPDKTFIFQNSEFT- 159
F + L IQITDDEKFLF++ + FE K NI DIIA F+P TFIF+N+ +
Sbjct: 207 VFSLPLVIQITDDEKFLFRD-VPFEGAKADELIRSNIKDIIAFNFNPRHTFIFRNTHYMG 265
Query: 160 KIYEMAIPIAKKINFSMAKAVFGFTEQSKIGMIFFPAIQIAPTFF-----------EKRR 208
+Y + + + + + K G T+ +G + FPA Q AP F R
Sbjct: 266 DMYPTVLRLQRSMTGNAVKHTLGITDSDNVGKLAFPATQAAPCFSTAFRRVLRNGDRPMR 325
Query: 209 CLIPAAIDQDPYWRLQRDFAESLGYYKTAAIHSKFVPSLTSLSGKMSASKPET-AIYLTD 267
CLIP AIDQDP++ L R A L A +H+KF+P+L L KMS+S E I L D
Sbjct: 326 CLIPCAIDQDPFFVLTRAAALRLKQLPPALLHTKFLPALKGLEHKMSSSAEEKGVITLHD 385
Query: 268 SPEDVEKKVWKFALTGGRPTLKEQREKGGEPEKCVVFKWLEIFFEEDDKKLKERYYACKN 327
+ + V KK+ + A +GG TL++ +E G E V +++L FF DD + ++
Sbjct: 386 TDKQVRKKL-RRAFSGGCATLEQMQETGANLELDVAYQYLR-FFCPDDTLFADVTQRYRS 443
Query: 328 GELTCGECKRYLIS-KIQEFLKEHQKRR 354
G L GE K I+E L + ++RR
Sbjct: 444 GTLNSGEVKDLAADCIIREVLHDWRERR 471
>sp|Q9Y924|SYW_AERPE TRYPTOPHANYL-TRNA SYNTHETASE (TRYPTOPHAN--TRNA LIGASE) (TRPRS)
>gi|7437514|pir||D72477 probable tryptophanyl-tRNA
synthetase APE2461 - Aeropyrum pernix (strain K1)
>gi|5106165|dbj|BAA81476.1| (AP000064) 374aa long
hypothetical tryptophanyl-tRNA synthetase [Aeropyrum
pernix]
Length = 374
Score = 190 bits (478), Expect = 2e-47
Identities = 122/363 (33%), Positives = 187/363 (50%), Gaps = 17/363 (4%)
Query: 6 KVTPWEVEGVVDYNKLIEHFGTSPLTEEL-LEKTAELTKSELPLFFRRKFFFSHRDYDKV 64
++ PW + DY++L+ FG P +E L L + A + S L RR F HRD+DK+
Sbjct: 7 RLDPWGAVEIKDYDRLLRTFGIRPFSEVLPLLRKAGMEPSFL---MRRGIIFGHRDFDKI 63
Query: 65 LQDYEEGRGFFLYTGRGPSGPMHIGHIIPFFATKWLQEKFGVNLYIQITDDEKFLFKENL 124
L+ G + TG PSG H GH + +LQ K G +++ I D E F +
Sbjct: 64 LEAKARGERVAVLTGFMPSGKFHFGHKLTVDQLIYLQ-KNGFKVFVAIADAEAFAVRRIG 122
Query: 125 TFEDTKHWAYENILDIIAVGFDP-DKTFIFQNSEFTKIYEMAIPIAKKINFSMAKAVFGF 183
E + E I ++IA+G DP D F FQ + T + + + K+ + +A++G
Sbjct: 123 REEAVRIAVEEYIANMIALGLDPKDTEFYFQTNRGTPYFRLIQLFSGKVTAAEMEAIYGE 182
Query: 184 TEQSKIGMIFFPAIQIAPTFFEK----RRCLIPAAIDQDPYWRLQRDFAESLG----YYK 235
+K+ A I ++ R ++P DQDP+ RL RD A+ + +
Sbjct: 183 LTPAKMMASLTQAADILHVQLDEYGGYRHVVVPVGADQDPHLRLTRDLADRMAGVVELER 242
Query: 236 TAAIHSKFVPSLTSLSGKMSASKPETAIYLTDSPEDVEKKVWKFALTGGRPTLKEQREKG 295
A+ + K P L KMS+S+P++ I+LTD PE K+++ ALTGGR T +EQR G
Sbjct: 243 PASTYHKLQPGLDGR--KMSSSRPDSTIFLTDPPEVARNKLFR-ALTGGRATAEEQRRLG 299
Query: 296 GEPEKCVVFKWLEIFFEEDDKKLKERYYACKNGELTCGECKRYLISKIQEFLKEHQKRRK 355
G PE C V+ DD ++K Y +C+ G++ CGECK+ K++ FL EHQ R +
Sbjct: 300 GVPEVCSVYHMDLYHLMPDDGEVKHIYTSCRLGKILCGECKQIAWEKLERFLAEHQSRLE 359
Query: 356 KAE 358
KA+
Sbjct: 360 KAK 362
>gi|11499284 tryptophanyl-tRNA synthetase (trpS) [Archaeoglobus fulgidus]
>gi|3122910|sp|O28579|SYW_ARCFU TRYPTOPHANYL-TRNA
SYNTHETASE (TRYPTOPHAN--TRNA LIGASE) (TRPRS)
>gi|7484001|pir||E69461 tryptophanyl-tRNA synthetase
(trpS) homolog - Archaeoglobus fulgidus
>gi|2648859|gb|AAB89554.1| (AE000986) tryptophanyl-tRNA
synthetase (trpS) [Archaeoglobus fulgidus]
Length = 420
Score = 164 bits (411), Expect = 2e-39
Identities = 116/421 (27%), Positives = 185/421 (43%), Gaps = 80/421 (19%)
Query: 7 VTPWEVEGVVDYNKLIEHFGTSPLTEELLEKTAELTKSELPLFFRRKFFFSHRDYDKVLQ 66
VTPWEVEGV+DY+KLIE FG P +E L E + RR F HRDY ++++
Sbjct: 3 VTPWEVEGVIDYSKLIEEFGMQPFSEVLPE------IDNPHILMRRGAIFGHRDYWRIIE 56
Query: 67 DYEEGRGFFLYTGRGPSGPMHIGHIIPFFATKWLQEKFGVNLYIQITDDEKFLFKENLTF 126
++ + + +G PSG H GH + W Q G ++ I D E + L++
Sbjct: 57 AMQKKEPWAVMSGFMPSGLPHFGHKMTMDEIVWHQSA-GGKAFVAIADMEAHSVR-GLSW 114
Query: 127 EDTKHWAYENILDIIAVGFDPDKTFIFQNSEFTKIYEMAIPIAKKINFSMAKAVFGFTEQ 186
E T+ I IIA+G D FQ S+ + + ++A ++ ++NFS +A++GF
Sbjct: 115 EKTRELGMLYIKSIIALGLREDAVIYFQ-SKSSHVKDLAFELSAEVNFSELRAIYGFNSD 173
Query: 187 SKIGMIFFPAIQIA-------PTFFEKRRCLIPAAIDQDPYWRLQRDFAESLGYYKTAAI 239
+ + +F AIQ A F + ++P DQDP+ RL RD A + + +
Sbjct: 174 TSLAKMFVTAIQAADILHPQLSDFGGPKPVVVPVGADQDPHMRLTRDLAARISIFSFEPV 233
Query: 240 H----------SKFVPSLTSLSGKMSASKPETAIYLTDSPEDVEKKVWKF---------- 279
++++ SL L + I+ E++E+ V K
Sbjct: 234 EGGVRVRSRKGAEYLSSLRDLEFDKKIYEEHMDIF--GEAEEIERAVRKIEVEIGGFAFI 291
Query: 280 -----------ALTG-------------------------------GRPTLKEQREKGGE 297
LTG GR T +EQR GGE
Sbjct: 292 PPSSTYHRFTTGLTGGKMSSSKPESYISLLDPPEEGAKKVMKAFTGGRATAEEQRRLGGE 351
Query: 298 PEKCVVFKWLEIFFEEDDKKLKERYYACKNGELTCGECKRYLISKIQEFLKEHQKRRKKA 357
P++CVVF+ + D++L + C+ G L CG+CK+ ++ FLKEHQ++ +
Sbjct: 352 PDRCVVFELYSFHLIDSDEELNQIEAECREGRLLCGKCKKMAAELVKSFLKEHQEKMEAV 411
Query: 358 E 358
+
Sbjct: 412 D 412
>gb|AAB60257.1| (U02595) tryptophanyl tRNA synthetase [Oryctolagus cuniculus]
Length = 149
Score = 144 bits (359), Expect = 2e-33
Identities = 72/147 (48%), Positives = 97/147 (65%), Gaps = 6/147 (4%)
Query: 49 FFRRKFFFSHRDYDKVLQDYEEGRGFFLYTGRGPSGP-MHIGHIIPFFATKWLQEKFGVN 107
F RR FFSHRD ++VL YE + F+LYTGRGPS MH+GH+IPF TKWLQ+ F V
Sbjct: 4 FLRRGIFFSHRDMNQVLDAYENKKPFYLYTGRGPSSEAMHVGHLIPFIFTKWLQDVFDVP 63
Query: 108 LYIQITDDEKFLFKENLTFEDTKHWAYENILDIIAVGFDPDKTFIFQNSEFTKI----YE 163
L +Q++DDEK+L+K+ LT E + EN DIIA GFD +KTFIF + ++ + Y+
Sbjct: 64 LVVQMSDDEKYLWKD-LTLEQVYGYTLENAKDIIACGFDVNKTFIFSDLDYMGMSPGFYK 122
Query: 164 MAIPIAKKINFSMAKAVFGFTEQSKIG 190
+ I K + F+ K +FGFT+ IG
Sbjct: 123 NVVKIQKHVTFNQVKGIFGFTDSDCIG 149
>sp|O96771|SYW_ENCCU TRYPTOPHANYL-TRNA SYNTHETASE (TRYPTOPHAN--TRNA LIGASE) (TRPRS)
>gi|11271109|pir||T43806 tryptophan--tRNA ligase (EC
6.1.1.2) [imported] - Encephalitozoon cuniculi
(fragment) >gi|3849866|emb|CAA10034.1| (AJ012470)
tryptophanyl tRNA synthetase [Encephalitozoon cuniculi]
Length = 134
Score = 115 bits (285), Expect = 9e-25
Identities = 56/125 (44%), Positives = 78/125 (61%), Gaps = 9/125 (7%)
Query: 6 KVTPWEVEGV--------VDYNKLIEHFGTSPLTEELLEKTAELTKSELPLFFRRKFFFS 57
++TPW+VE V +DY+K+I FG + L ++ +L+ FFRR F+
Sbjct: 5 RITPWDVEVVSTDEVPVAIDYDKIINQFGCEKFNQALADRLEKLSGKPAHYFFRRGIVFA 64
Query: 58 HRDYDKVLQDYEEGRGFFLYTGRGPSG-PMHIGHIIPFFATKWLQEKFGVNLYIQITDDE 116
HRD++ +L + R F+LYTGRGPS MHIGH IPF K++Q+ F + L IQITDDE
Sbjct: 65 HRDFNLLLDEIANNRPFYLYTGRGPSSKTMHIGHTIPFLLCKYMQDAFKIRLVIQITDDE 124
Query: 117 KFLFK 121
KFL+K
Sbjct: 125 KFLWK 129
>gb|AAG20338.1| (AE005107) tryptophanyl-tRNA synthetase; TrpS1 [Halobacterium sp.
NRC-1]
Length = 513
Score = 94.4 bits (231), Expect = 2e-18
Identities = 52/127 (40%), Positives = 72/127 (55%), Gaps = 4/127 (3%)
Query: 232 GYYKTAAIHSKFVPSLTSLSGKMSASKPETAIYLTDSPEDVEKKVWKFALTGGRPTLKEQ 291
G+ ++++ +F+ LT GKMS+S+P + I L D PE KV A TGGR T EQ
Sbjct: 374 GFVPPSSVYHRFMTGLTG--GKMSSSEPASHISLLDDPETGADKV-AAATTGGRDTAAEQ 430
Query: 292 REKGGEPEKCVVFKWLEIFFEEDDKKLKERYYA-CKNGELTCGECKRYLISKIQEFLKEH 350
RE+GGEP+ C V++ DD L E YA C NG+ CG CK + +FL+ H
Sbjct: 431 RERGGEPDDCPVYELYAYLLAGDDDALAEEVYAECANGDRLCGGCKEQAADLMAQFLETH 490
Query: 351 QKRRKKA 357
Q+ R+ A
Sbjct: 491 QENREAA 497
Score = 94.4 bits (231), Expect = 2e-18
Identities = 67/237 (28%), Positives = 110/237 (46%), Gaps = 12/237 (5%)
Query: 3 EDFKVTPWEVEGVVDYNKLIEHFGTSPLTEELLEKTAELTKSELPLFFRRKFFFSHRDYD 62
+D + PW + DY L + FG E++L+ T L RR F HRDY
Sbjct: 13 DDVALDPWGSATISDYRALFDEFGIEAF-EDVLDGVP--TPHSL---MRRAIIFGHRDYR 66
Query: 63 KVLQDYEEGRGFFLYTGRGPSGPMHIGHIIPFFATKWLQEKFGVNLYIQITDDEKFLFKE 122
+V F +G P+G HIGH + F W Q++ G + Y I D E +
Sbjct: 67 RVAAAMRNDEPFAALSGFMPTGDPHIGHKMVFDELIWHQQQ-GGDAYALIADLEAHSAR- 124
Query: 123 NLTFEDTKHWAYENILDIIAVGFDPDKTFIFQNSEFTKIYEMAIPIAKKINFSMAKAVFG 182
L + + A + +L ++A+GFD D+ +++ S ++ ++A + + N S +A++G
Sbjct: 125 GLDWAEIDEHAEDYLLSLLALGFDADEGELYRQSTNRELQDLAFELGIEANTSEFEAIYG 184
Query: 183 FTEQSKIGMIFFPAIQIA----PTFFEKRRCLIPAAIDQDPYWRLQRDFAESLGYYK 235
F + + + Q+A P + +IP DQDP+ R RD AE Y+K
Sbjct: 185 FGGDTDVSHMQSVVTQMADILYPQLDAPKPTVIPVGPDQDPHVRFARDLAERTRYFK 241
>emb|CAC12336.1| (AL445066) tryptophanyl-tRNA synthetase related protein
[Thermoplasma acidophilum]
Length = 426
Score = 92.4 bits (226), Expect = 8e-18
Identities = 50/139 (35%), Positives = 83/139 (58%), Gaps = 8/139 (5%)
Query: 226 DFAESLGYYKTAAIHSKFVPSLTSLSGKMSASKPETAIYLTDSPEDVEKKVWKFALTGGR 285
DFA + +A + K + L GKMS+S P++ I L D P++ +K+ +TGGR
Sbjct: 293 DFA----FIAPSATYQKLMKGLKG--GKMSSSVPDSLISLNDDPKEARRKIMA-GMTGGR 345
Query: 286 PTLKEQREKGGEPEKCVVFKWLEIFFEEDDKKLKERYYACKNGELTCGECKRYLISKIQE 345
T +EQR GGEP++C +F L + +DDK +KE Y C+NG+ CG CKR + ++
Sbjct: 346 DTEEEQRRLGGEPDRCPIFD-LYNYEIDDDKHVKEVYDDCRNGKRMCGFCKREIADRMAS 404
Query: 346 FLKEHQKRRKKAEKQIEKF 364
+L + K+R++A +++ +
Sbjct: 405 WLSDLSKKREEAREKLSLY 423
Score = 73.7 bits (178), Expect = 3e-12
Identities = 59/233 (25%), Positives = 98/233 (41%), Gaps = 23/233 (9%)
Query: 7 VTPWEVEGVVDYNKLIEHFGTSPLTEELLEKTAELTKSELPLFFRRKFFFSHRDYDKVLQ 66
+ PW DY +L FG + FRR R D +
Sbjct: 2 INPWSSSDFFDYERLKREFGIGDMNVPFDH-----------FLFRRHLILGQRSIDYIDY 50
Query: 67 DYEEGRGFFLYTGRGPSGPMHIGHIIPFFATKWLQEKFGVNLYIQITDDEKFLFKENLTF 126
+ F + TG PSG MH+G+ + Q K G + I + D E + + ++
Sbjct: 51 ALKHHMKFNVMTGLMPSGEMHLGNKSAIDQVIFFQ-KLGGRVSIAVADLESYSTR-GISL 108
Query: 127 EDTKHWAYEN-ILDIIAVGFDPDKTFIFQNSEFTKIYEMAIPIAKKINFSMAKAVFGFTE 185
E + A E IL+ IA+G +P + I+ S + + +A + + N S ++++GFT+
Sbjct: 109 ERAREVAIEKYILNYIAMGLEPCE--IYFQSRNSDVQFLAYMLGNRTNMSELRSLYGFTD 166
Query: 186 QSKIGMIFFPAIQIAPTFFEKRR-------CLIPAAIDQDPYWRLQRDFAESL 231
+ I P IQ A + + ++P DQDP+ RL RD A+ +
Sbjct: 167 THDLLHINAPLIQAADVLHTQMKKYGGPAPTVVPVGFDQDPHLRLMRDLAKRM 219
>sp|O67115|SYW_AQUAE TRYPTOPHANYL-TRNA SYNTHETASE (TRYPTOPHAN--TRNA LIGASE) (TRPRS)
>gi|7437507|pir||H70385 tryptophan--tRNA ligase (EC
6.1.1.2) - Aquifex aeolicus >gi|2983495|gb|AAC07073.1|
(AE000717) tryptophanyl-tRNA synthetase [Aquifex
aeolicus]
Length = 395
Score = 88.9 bits (217), Expect = 9e-17
Identities = 81/295 (27%), Positives = 138/295 (46%), Gaps = 40/295 (13%)
Query: 110 IQITDDEKFLFKENLTFEDTKHWAYENILDIIAVGFDPDKTF---IFQNSEFTKIY---- 162
+++TD EK FKE L ++ I+++I ++ F + +N T I
Sbjct: 116 LRLTDLEKE-FKEKLKERISE------IVNLIPFNITKEEKFREHLLENLTQTMIEALFE 168
Query: 163 -EMAIPIAKKINFSMAKAVFGFTEQSKIGMIFFPAIQIAPTFFEKRRCLIPAAIDQDPYW 221
E+ I K++N S F E G + +P +Q A K +P DQ P+
Sbjct: 169 GEIEPEILKRLNVSKRD----FYETDTFGFLGYPVLQAADILIYKGEG-VPVGEDQLPHI 223
Query: 222 RLQRDFAESLG------YYKTAAIHSKFVPSLTSLSGKMSASKPETAIYLTDSPEDVEKK 275
L R+ A + + A+ ++ P + G+ + A++ +D E+VEKK
Sbjct: 224 ELSREIARRFNRLYGKIFPEPKALLTE-TPKIPGTDGRKMSKSYGNAVFFSDEKEEVEKK 282
Query: 276 VWKFALTGGRPTLKEQREKGGEPEKCVVFKWLEIFFEEDD--KKLKERYYACKNGELTCG 333
V K K ++ G PE C VF W ++F ++++ KK++E C+ G L C
Sbjct: 283 VMKMFTD----PQKIRKNDPGRPEICPVFSWHKLFTKDEELVKKIEED---CRAGRLGCV 335
Query: 334 ECKRYLISKIQEFLKEHQKRRKKAEKQI----EKFKYTGKLAQEMWDKAIPEPLK 384
ECKR L+ ++EFL+ ++RR++ EK+I E F + A+E+ K + E K
Sbjct: 336 ECKRILLKHLEEFLEPIRERRRELEKRINEIEEVFYENSRKAREIAQKTMEEVRK 390
>sp|Q9WYW2|SYW_THEMA TRYPTOPHANYL-TRNA SYNTHETASE (TRYPTOPHAN--TRNA LIGASE) (TRPRS)
>gi|7437509|pir||C72370 tryptophan--tRNA ligase (EC
6.1.1.2) - Thermotoga maritima (strain MSB8)
>gi|4981003|gb|AAD35577.1|AE001726_11 (AE001726)
tryptophanyl-tRNA synthetase [Thermotoga maritima]
Length = 328
Score = 73.4 bits (177), Expect = 4e-12
Identities = 62/287 (21%), Positives = 121/287 (41%), Gaps = 23/287 (8%)
Query: 76 LYTGRGPSGPMHIGHIIPFFATKWLQEKFGVNLYIQITDDEKFLFKENLTFEDTKHWAYE 135
+ +G P+G +HIGH++ W++ + N D L K + +
Sbjct: 3 ILSGMRPTGKLHIGHLVGALEN-WVKLQEEGNECFYFVADWHALTTHYDDVSKLKEYTRD 61
Query: 136 NILDIIAVGFDPDKTFIF------QNSEFTKIYEMAIPIA---KKINFSMAKAVFGFTEQ 186
+ +A G DP+K+ IF +++E ++ M + ++ + + K+ + +
Sbjct: 62 LVRGFLACGIDPEKSVIFVQSGVKEHAELALLFSMIVSVSRLERVPTYKEIKSELNYKDL 121
Query: 187 SKIGMIFFPAIQIAPTFFEKRRCLIPAAIDQDPYWRLQRDFAESLGYY------KTAAIH 240
S G + +P +Q A K +P DQ + L R+ A Y + AI
Sbjct: 122 STAGFLIYPVLQAADILIYKAEG-VPVGEDQVYHIELTREIARRFNYLYDEVFPEPEAIL 180
Query: 241 SKFVPSLTSLSGKMSASKPETAIYLTDSPEDVEKKVWKFALTGGRPTLKEQREKGGEPEK 300
S+ VP L G+ + I L S +++E+ + + R +R G PE
Sbjct: 181 SR-VPKLPGTDGRKMSKSYGNIINLEISEKELEQTILRMMTDPAR----VRRSDPGNPEN 235
Query: 301 CVVFKWLEIFFEEDDKKLKERYYACKNGELTCGECKRYLISKIQEFL 347
C V+K+ + F+ +++ K + C + C +CK+ L+ ++ L
Sbjct: 236 CPVWKYHQA-FDISEEESKWVWEGCTTASIGCVDCKKLLLKNMKRKL 281
>sp|Q9Z7A4|SYW_CHLPN TRYPTOPHANYL-TRNA SYNTHETASE (TRYPTOPHAN--TRNA LIGASE) (TRPRS)
>gi|7437512|pir||C72034 tryptophan--tRNA ligase (EC
6.1.1.2) [similarity] - Chlamydophila pneumoniae
(strains CWL029 and AR39) >gi|4377113|gb|AAD18940.1|
(AE001661) Tryptophanyl tRNA Synthetase [Chlamydophila
pneumoniae CWL029] >gi|7189982|gb|AAF38841.1| (AE002263)
tryptophanyl-tRNA synthetase [Chlamydophila pneumoniae
AR39] >gi|8979176|dbj|BAA99010.1| (AP002548)
tryptophanyl tRNA synthetase [Chlamydophila pneumoniae
J138]
Length = 344
Score = 71.0 bits (171), Expect = 2e-11
Identities = 76/300 (25%), Positives = 126/300 (41%), Gaps = 30/300 (10%)
Query: 78 TGRGPSGPMHIGHIIPFFATKW-LQEKFGVNLYIQITDDEKFLFK-ENLTFEDTKHWAYE 135
TG P+G +H+GH + + LQ + + I D K D + YE
Sbjct: 9 TGDRPTGKLHLGHWVGSIKNRLELQNSPEYDCFFIIADLHTLTTKIRKEEVLDVDNHIYE 68
Query: 136 NILDIIAVGFDPDKTFIFQNSEFTKIYEMAIPIAKKINFSMAKAVFGFTEQSK------- 188
+ D ++VG DP K+ I+ S +IYE+ + + I+ + + + ++
Sbjct: 69 VLADWLSVGIDPTKSIIYLQSAIPEIYELHLLFSMLISINRVMGIPSLKDMARNASIEEG 128
Query: 189 ---IGMIFFPAIQIAPTFFEKRRCLIPAAIDQDPYWRLQRDFAESLG--YYKTAAIHSKF 243
G+I +P +Q A K + +P D + + L RD A + Y +
Sbjct: 129 SLSYGLIGYPILQSADILLAKAQ-FVPVGKDNEAHVELTRDIARNFNRLYGQVFPEPEVL 187
Query: 244 VPSLTSL-----SGKMSASKPETAIYLTDSPEDVEKKVWKFALTGGRPTLKEQREKGGEP 298
LTSL GKMS S AIYL+DS + +KV K R G P
Sbjct: 188 QGELTSLVGIDGQGKMSKS-ANNAIYLSDSDATITEKVRKMYTDPNRIRATTPGRVEGNP 246
Query: 299 EKCVVFKWLEIF--FEEDDKKLKERYYACKNGELTCGECKRYLISKIQEFLKEHQKRRKK 356
+F + +IF +++ ++ K RY + G + E K L ++ FLK ++RR +
Sbjct: 247 ----LFIYHDIFNPHKDEVEEFKARY---RQGCIKDIEVKARLAEELIHFLKPIKERRSE 299
>gb|AAF15095.1|AF110953_1 (AF110953) tryptophanyl-tRNA synthetase [Trypanosoma cruzi]
Length = 157
Score = 69.1 bits (166), Expect = 8e-11
Identities = 53/160 (33%), Positives = 81/160 (50%), Gaps = 14/160 (8%)
Query: 208 RCLIPAAIDQDPYWRLQRDFAESLGYYKTAAIHSKFVPSLTSLSGKMSAS-KPETAIYLT 266
+C+IP AIDQDP++ L R+ A +H+KF+P+L KMS+S + I L
Sbjct: 1 KCIIPCAIDQDPFFLLARN---------VALLHTKFLPALKGAQFKMSSSAEGNGVITLH 51
Query: 267 DSPEDVEKKVWKFALTGGRPTLKEQREKGGEPEKCVVFKWLEIFFEEDDKKLKERYYACK 326
D+ ++V KK+ K A +GG TL++ R +G V ++ + FF DD L E
Sbjct: 52 DTEQEVRKKLRK-AFSGGGGTLEDMRAEGVNLHADVAYQLIR-FFCPDDNLLAEVTSKHS 109
Query: 327 NGELTCGECKRYLIS-KIQEFLKEHQKRRK-KAEKQIEKF 364
GE+ E K ++ FL Q RR + +E+F
Sbjct: 110 RGEMNSAEVKDLAADVVVRHFLSGWQARRAGVTDADVEQF 149
>gb|AAG20359.1| (AE005109) tyrosyl-tRNA synthetase; TyrS [Halobacterium sp. NRC-1]
Length = 327
Score = 69.1 bits (166), Expect = 8e-11
Identities = 60/223 (26%), Positives = 105/223 (46%), Gaps = 14/223 (6%)
Query: 62 DKVLQDYEEGRGFFLYTGRGPSGPMHIGHIIPFFATKWLQEKFGVNLYIQITDDEKFLFK 121
++V + E+ G +Y G PSG +H+GH++ LQ+ G+ + + + D +L
Sbjct: 18 EEVRELAEDPEGKRVYVGYEPSGVLHLGHLLTANKLMDLQDA-GMEVVVLLADVHAYL-N 75
Query: 122 ENLTFEDTKHWAYENILDIIAVGFDPDKTFIFQNSEFT-------KIYEMAIPIA-KKIN 173
+ +FE+ + A + +A G D D+T S F ++ M + + K+
Sbjct: 76 DKGSFEEIRATADQMKAQFLAYGLDEDQTEFVLGSSFQLDEDYELDLHAMQVETSLKRAQ 135
Query: 174 FSMAKAVFGFTEQSKIGMIFFPAIQIAPTFFEKRRCLIPAAIDQDPYWRLQRDFAESLGY 233
+MA+ G E K+ + +P +Q + I +DQ L R+ S+GY
Sbjct: 136 RAMAEIQSG--ETPKVSHVVYPLMQALDIEYLDLDLAI-GGMDQRKVHMLAREELPSVGY 192
Query: 234 YKTAAIHSKFVPSLTSLSGKMSASKPETAIYLTDSPEDVEKKV 276
K +H+ + L S GKMS+S+ T I + DS D+E+KV
Sbjct: 193 EKRPVLHTPIIGDLGSGDGKMSSSEGVT-ISMEDSTADIEEKV 234
Database: ./suso.pep
Posted date: Jul 6, 2001 5:57 PM
Number of letters in database: 840,471
Number of sequences in database: 2977
Database: /banques/blast2/nr.pep
Posted date: Dec 14, 2000 12:46 PM
Number of letters in database: 188,266,275
Number of sequences in database: 595,510
Lambda K H
0.321 0.139 0.422
Gapped
Lambda K H
0.270 0.0470 0.230
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 154903442
Number of Sequences: 2977
Number of extensions: 6911577
Number of successful extensions: 17580
Number of sequences better than 1.0e-10: 37
Number of HSP's better than 0.0 without gapping: 28
Number of HSP's successfully gapped in prelim test: 9
Number of HSP's that attempted gapping in prelim test: 17398
Number of HSP's gapped (non-prelim): 42
length of query: 385
length of database: 189,106,746
effective HSP length: 53
effective length of query: 332
effective length of database: 157,386,935
effective search space: 52252462420
effective search space used: 52252462420
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 41 (21.8 bits)
S2: 166 (69.1 bits)